Indicus|evm.model.CM009491.1.1 Q8NGG7 OR8A1_HUMAN 58.621 0.678571 0.257669 OR8A1 - Olfactory receptor 8A1 - Homo sapiens (Human) - OR8A1 gene Odorant receptor. Indicus|evm.model.CM009491.1.2 Q8NGL2 OR5L1_HUMAN 52.795 0.969697 0.530547 OR5L1 - Olfactory receptor 5L1 - Homo sapiens (Human) - OR5L1 gene Odorant receptor. Indicus|evm.model.CM009491.1.3 Q9Y696 CLIC4_HUMAN 77.682 0.353659 2.59289 CLIC4 - Chloride intracellular channel protein 4 - Homo sapiens (Human) - CLIC4 gene Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Indicus|evm.model.CM009491.1.4 P53805 RCAN1_HUMAN 78.161 0.408867 0.805556 RCAN1 - Calcipressin-1 - Homo sapiens (Human) - RCAN1 gene Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). Indicus|evm.model.CM009491.1.5 Q5R6X7 CBX3_PONAB 90.710 0.989011 0.994536 CBX3 - Chromobox protein homolog 3 - Pongo abelii (Sumatran orangutan) - CBX3 gene Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). Indicus|evm.model.CM009491.1.6 Q6XXM7 RCAN1_SHEEP 100.000 0.989899 1.00508 RCAN1 - Calcipressin-1 - Ovis aries (Sheep) - RCAN1 gene Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Indicus|evm.model.CM009491.1.7 Q9XSP1 KCNE1_FELCA 79.365 0.961538 1.00775 KCNE1 - Potassium voltage-gated channel subfamily E member 1 - Felis catus (Cat) - KCNE1 gene Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Indicus|evm.model.CM009491.1.8 Q5E975 TM230_BOVIN 81.667 0.982143 0.933333 TMEM230 - Transmembrane protein 230 - Bos taurus (Bovine) - TMEM230 gene Involved in trafficking and recycling of synaptic vesicles. Indicus|evm.model.CM009491.1.9 P0DPE8 SM34B_HUMAN 68.750 0.888112 1.02878 SMIM34B - Small integral membrane protein 34B - Homo sapiens (Human) - SMIM34B gene Indicus|evm.model.CM009491.1.10 F1MIW6 FA243_BOVIN 99.383 0.98773 0.649402 FAM243 - Protein FAM243 - Bos taurus (Bovine) - FAM243 gene Indicus|evm.model.CM009491.1.11 A6H770 SI11A_BOVIN 100.000 0.210317 4.34483 SMIM11A - Small integral membrane protein 11A - Bos taurus (Bovine) - SMIM11A gene Indicus|evm.model.CM009491.1.12 P82931 RT06_BOVIN 98.182 0.519048 1.69355 MRPS6 - 28S ribosomal protein S6, mitochondrial - Bos taurus (Bovine) - MRPS6 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit rRNA binding, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009491.1.13 P53793 SC5A3_BOVIN 99.304 0.997218 1.00139 SLC5A3 - Sodium/myo-inositol cotransporter - Bos taurus (Bovine) - SLC5A3 gene Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function. Indicus|evm.model.CM009491.1.14 P13621 ATPO_BOVIN 99.531 0.773723 1.28638 ATP5PO - ATP synthase subunit O, mitochondrial precursor - Bos taurus (Bovine) - ATP5PO gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Indicus|evm.model.CM009491.1.15 Q15811 ITSN1_HUMAN 94.480 0.998812 0.97792 ITSN1 - Intersectin-1 - Homo sapiens (Human) - ITSN1 gene Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). Indicus|evm.model.CM009491.1.16 Q59A28 QORL1_BOVIN 95.082 0.950521 1.10029 CRYZL1 - Quinone oxidoreductase-like protein 1 - Bos taurus (Bovine) - CRYZL1 gene Indicus|evm.model.CM009491.1.17 Q9NYP3 DONS_HUMAN 86.928 0.880769 0.918728 DONSON - Protein downstream neighbor of Son - Homo sapiens (Human) - DONSON gene Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. Indicus|evm.model.CM009491.1.18 Q9QX47 SON_MOUSE 98.289 0.166124 1.00491 Son - Protein SON - Mus musculus (Mouse) - Son gene RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3' (By similarity). Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (By similarity). May also regulate the ghrelin signaling in hypothalamic neuron by acting as a negative regulator of GHSR expression (PubMed:20876580). Indicus|evm.model.CM009491.1.19 Q59A32 PUR2_BOVIN 99.901 0.998022 1.00099 GART - Trifunctional purine biosynthetic protein adenosine-3 - Bos taurus (Bovine) - GART gene cytosol, phosphoribosylamine-glycine ligase activity, phosphoribosylformylglycinamidine cyclo-ligase activity, adenine biosynthetic process, purine nucleotide biosynthetic process Indicus|evm.model.CM009491.1.20 Q9NX36 DJC28_HUMAN 83.421 0.994751 0.981959 DNAJC28 - DnaJ homolog subfamily C member 28 - Homo sapiens (Human) - DNAJC28 gene May have a role in protein folding or as a chaperone. Indicus|evm.model.CM009491.1.22 Q5R4C3 TM50B_PONAB 100.000 0.987421 1.00633 TMEM50B - Transmembrane protein 50B - Pongo abelii (Sumatran orangutan) - TMEM50B gene Indicus|evm.model.CM009491.1.23 P38484 INGR2_HUMAN 64.516 0.872521 1.04748 IFNGR2 - Interferon gamma receptor 2 precursor - Homo sapiens (Human) - IFNGR2 gene Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114). Indicus|evm.model.CM009491.1.24 Q04790 INAR1_BOVIN 100.000 0.996435 1.00179 IFNAR1 - Interferon alpha/beta receptor 1 precursor - Bos taurus (Bovine) - IFNAR1 gene Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:8318540). Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). Indicus|evm.model.CM009491.1.25 Q95141 INAR2_BOVIN 99.035 0.582207 1.67547 IFNAR2 - Interferon alpha/beta receptor 2 precursor - Bos taurus (Bovine) - IFNAR2 gene Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-mediated STAT1, STAT2 and STAT3 activation. Indicus|evm.model.CM009491.1.26 Q6WV90 H4_MYTGA 97.087 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009491.1.27 Q90XB3 OLIG2_CHICK 78.125 0.233083 0.446309 OLIG2 - Oligodendrocyte transcription factor 2 - Gallus gallus (Chicken) - OLIG2 gene Required for oligodendrocyte and motor neuron specification in the spinal cord. Indicus|evm.model.CM009491.1.28 Q13516 OLIG2_HUMAN 94.857 0.813084 0.662539 OLIG2 - Oligodendrocyte transcription factor 2 - Homo sapiens (Human) - OLIG2 gene Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. Indicus|evm.model.CM009491.1.29 P24049 RL17_RAT 64.815 0.929293 0.538043 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009491.1.30 Q9NYP8 CU062_HUMAN 78.539 0.990868 1 C21orf62 - Uncharacterized protein C21orf62 precursor - Homo sapiens (Human) - C21orf62 gene Indicus|evm.model.CM009491.1.31 Q9Y5B6 PAXB1_HUMAN 98.130 0.997509 0.875682 PAXBP1 - PAX3- and PAX7-binding protein 1 - Homo sapiens (Human) - PAXBP1 gene Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity). Indicus|evm.model.CM009491.1.32 O18964 SYNJ1_BOVIN 93.168 0.822478 1.18278 SYNJ1 - Synaptojanin-1 - Bos taurus (Bovine) - SYNJ1 gene Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (PubMed:9199318). Indicus|evm.model.CM009491.1.35 P57076 CF298_HUMAN 93.103 0.993127 1.00345 CFAP298 - Cilia- and flagella-associated protein 298 - Homo sapiens (Human) - CFAP298 gene Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744). Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity). Indicus|evm.model.CM009491.1.36 Q68US5 EVA1C_PANTR 88.662 0.995475 1.00227 EVA1C - Protein eva-1 homolog C precursor - Pan troglodytes (Chimpanzee) - EVA1C gene Binds heparin. Indicus|evm.model.CM009491.1.37 O60287 NPA1P_HUMAN 78.047 0.995154 0.99956 URB1 - Nucleolar pre-ribosomal-associated protein 1 - Homo sapiens (Human) - URB1 gene fibrillar center, nucleolus, RNA binding, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009491.1.38 Q68UT4 MRAP_PANTR 79.348 0.65942 0.802326 MRAP - Melanocortin-2 receptor accessory protein - Pan troglodytes (Chimpanzee) - MRAP gene Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity). Indicus|evm.model.CM009491.1.39 A5D7N9 MS18A_BOVIN 100.000 0.991525 1.00426 MIS18A - Protein Mis18-alpha - Bos taurus (Bovine) - MIS18A gene Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Indicus|evm.model.CM009491.1.42 Q68UT7 HUNK_PANTR 91.964 0.9838 0.95098 HUNK - Hormonally up-regulated neu tumor-associated kinase - Pan troglodytes (Chimpanzee) - HUNK gene cytoplasm, nucleus, protein serine/threonine kinase activity, intracellular signal transduction, protein phosphorylation Indicus|evm.model.CM009491.1.43 O95104 SCAF4_HUMAN 92.254 0.998252 0.997384 SCAF4 - SR-related and CTD-associated factor 4 - Homo sapiens (Human) - SCAF4 gene Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF8, also acts as a suppressor of transcriptional readthrough (PubMed:31104839). Indicus|evm.model.CM009491.1.44 P00442 SODC_BOVIN 97.692 0.741379 1.14474 SOD1 - Superoxide dismutase [Cu-Zn] - Bos taurus (Bovine) - SOD1 gene Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Indicus|evm.model.CM009491.1.47 Q923D2 BLVRB_MOUSE 82.353 0.694444 0.349515 Blvrb - Flavin reductase (NADPH) - Mus musculus (Mouse) - Blvrb gene Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. Indicus|evm.model.CM009491.1.48 Q6R648 KR111_CAPHI 91.195 0.9875 1.00629 KRTAP11-1 - Keratin-associated protein 11-1 - Capra hircus (Goat) - KRTAP11-1 gene In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of wool keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Indicus|evm.model.CM009491.1.49 Q28580 KRA71_SHEEP 94.253 0.977273 1.03529 KRTAP7-1 - Keratin-associated protein 7-1 - Ovis aries (Sheep) - KRTAP7-1 gene In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Indicus|evm.model.CM009491.1.65 Q02958 KRA61_SHEEP 85.075 0.776471 1.0241 KRTAP6-1 - Keratin-associated protein 6-1 - Ovis aries (Sheep) - KRTAP6-1 gene In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Indicus|evm.model.CM009491.1.66 Q02958 KRA61_SHEEP 95.349 0.6 0.843373 KRTAP6-1 - Keratin-associated protein 6-1 - Ovis aries (Sheep) - KRTAP6-1 gene In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Indicus|evm.model.CM009491.1.69 Q02958 KRA61_SHEEP 80.769 0.6 1.0241 KRTAP6-1 - Keratin-associated protein 6-1 - Ovis aries (Sheep) - KRTAP6-1 gene In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Indicus|evm.model.CM009491.1.82 Q52KI8 SRRM1_MOUSE 69.930 0.337461 0.341438 Srrm1 - Serine/arginine repetitive matrix protein 1 - Mus musculus (Mouse) - Srrm1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. Indicus|evm.model.CM009491.1.83 Q5R5Q2 SRRM1_PONAB 76.730 0.985075 0.146129 SRRM1 - Serine/arginine repetitive matrix protein 1 - Pongo abelii (Sumatran orangutan) - SRRM1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. Indicus|evm.model.CM009491.1.84 Q8IUC0 KR131_HUMAN 61.404 0.987879 0.959302 KRTAP13-1 - Keratin-associated protein 13-1 - Homo sapiens (Human) - KRTAP13-1 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Indicus|evm.model.CM009491.1.85 Q8IUC0 KR131_HUMAN 63.462 0.974522 0.912791 KRTAP13-1 - Keratin-associated protein 13-1 - Homo sapiens (Human) - KRTAP13-1 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Indicus|evm.model.CM009491.1.86 Q6PEX3 KR261_HUMAN 48.571 0.983425 0.861905 KRTAP26-1 - Keratin-associated protein 26-1 - Homo sapiens (Human) - KRTAP26-1 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Indicus|evm.model.CM009491.1.87 Q3LI83 KR241_HUMAN 65.748 0.929368 1.05906 KRTAP24-1 - Keratin-associated protein 24-1 - Homo sapiens (Human) - KRTAP24-1 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Indicus|evm.model.CM009491.1.88 Q9Z260 CLD8_MOUSE 87.111 0.99115 1.00444 Cldn8 - Claudin-8 - Mus musculus (Mouse) - Cldn8 gene Tight-junction protein required for paracellular chloride transport in the kidney (PubMed:20921420, PubMed:25831548). Mediates recruitment of CLDN4 to tight junction in the kidney (PubMed:20921420, PubMed:25831548). Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009491.1.89 P56750 CLD17_HUMAN 78.667 0.99115 1.00893 CLDN17 - Claudin-17 - Homo sapiens (Human) - CLDN17 gene Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability. Indicus|evm.model.CM009491.1.90 Q38PU4 GRIK1_MACFA 96.113 0.975936 0.814815 GRIK1 - Glutamate receptor ionotropic, kainate 1 precursor - Macaca fascicularis (Crab-eating macaque) - GRIK1 gene Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus (By similarity). Indicus|evm.model.CM009491.1.91 Q38PU4 GRIK1_MACFA 97.647 0.807692 0.11329 GRIK1 - Glutamate receptor ionotropic, kainate 1 precursor - Macaca fascicularis (Crab-eating macaque) - GRIK1 gene Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus (By similarity). Indicus|evm.model.CM009491.1.92 O02751 CFDP2_BOVIN 70.635 0.457875 0.461149 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Indicus|evm.model.CM009491.1.93 O14867 BACH1_HUMAN 81.283 0.997305 1.00815 BACH1 - Transcription regulator protein BACH1 - Homo sapiens (Human) - BACH1 gene Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). Indicus|evm.model.CM009491.1.94 P58500 M3KCL_MOUSE 92.254 0.530075 1.87324 Map3k7cl - MAP3K7 C-terminal-like protein - Mus musculus (Mouse) - Map3k7cl gene Indicus|evm.model.CM009491.1.95 Q3ZCI9 TCPQ_BOVIN 100.000 0.996357 1.00182 CCT8 - T-complex protein 1 subunit theta - Bos taurus (Bovine) - CCT8 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.CM009491.1.96 Q08DA3 UBP16_BOVIN 99.879 0.997582 1.00121 USP16 - Ubiquitin carboxyl-terminal hydrolase 16 - Bos taurus (Bovine) - USP16 gene Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Indicus|evm.model.CM009491.1.98 Q5R9U9 RWD2B_PONAB 85.862 0.993127 0.912226 RWDD2B - RWD domain-containing protein 2B - Pongo abelii (Sumatran orangutan) - RWDD2B gene Indicus|evm.model.CM009491.1.99 O94822 LTN1_HUMAN 89.807 0.972988 1.02718 LTN1 - E3 ubiquitin-protein ligase listerin - Homo sapiens (Human) - LTN1 gene E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). Indicus|evm.model.CM009491.1.100 A0A2R8Y619 H2BE1_HUMAN 86.066 0.98374 1.0082 H2BE1 - Histone H2B type 2-E1 - Homo sapiens (Human) - H2BE1 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009491.1.101 Q9Y5N5 N6MT1_HUMAN 90.654 0.990698 1.00467 N6AMT1 - Methyltransferase N6AMT1 - Homo sapiens (Human) - N6AMT1 gene Methyltransferase that can methylate proteins and, to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583, PubMed:31636962, PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146, PubMed:31632689, PubMed:31636962). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008, PubMed:31636962, PubMed:31061526). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655). Indicus|evm.model.CM009491.1.104 Q6WV90 H4_MYTGA 99.029 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009491.1.105 Q9UNA0 ATS5_HUMAN 91.221 0.997861 1.00538 ADAMTS5 - A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor - Homo sapiens (Human) - ADAMTS5 gene Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. Indicus|evm.model.CM009491.1.106 Q9UHI8 ATS1_HUMAN 82.022 0.99794 1.00414 ADAMTS1 - A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor - Homo sapiens (Human) - ADAMTS1 gene Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. Indicus|evm.model.CM009491.1.107 Q96J86 CYYR1_HUMAN 87.097 0.583012 1.68182 CYYR1 - Cysteine and tyrosine-rich protein 1 precursor - Homo sapiens (Human) - CYYR1 gene Indicus|evm.model.CM009491.1.108 Q95241 A4_SAISC 97.603 0.99734 1.00133 APP - Amyloid-beta A4 protein precursor - Saimiri sciureus (Common squirrel monkey) - APP gene Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP (By similarity). Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity). Indicus|evm.model.CM009491.1.109 Q06546 GABPA_HUMAN 98.678 0.995604 1.0022 GABPA - GA-binding protein alpha chain - Homo sapiens (Human) - GABPA gene Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. Indicus|evm.model.CM009491.1.111 P02721 ATP5J_BOVIN 100.000 0.981651 1.00926 ATP5PF - ATP synthase-coupling factor 6, mitochondrial precursor - Bos taurus (Bovine) - ATP5PF gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes. Indicus|evm.model.CM009491.1.112 P57087 JAM2_HUMAN 90.747 0.936455 1.00336 JAM2 - Junctional adhesion molecule B precursor - Homo sapiens (Human) - JAM2 gene Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:11590146, PubMed:11823489, PubMed:24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:12239159). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:12070135). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity). Indicus|evm.model.CM009491.1.113 Q9NYK5 RM39_HUMAN 87.463 0.994048 0.994083 MRPL39 - 39S ribosomal protein L39, mitochondrial - Homo sapiens (Human) - MRPL39 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, RNA binding, mitochondrial translational elongation, mitochondrial translational termination Indicus|evm.model.CM009491.1.119 O15394 NCAM2_HUMAN 97.342 0.995918 0.585424 NCAM2 - Neural cell adhesion molecule 2 precursor - Homo sapiens (Human) - NCAM2 gene May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons. Indicus|evm.model.CM009491.1.121 P98072 ENTK_BOVIN 93.293 0.974737 0.917874 TMPRSS15 - Enteropeptidase precursor - Bos taurus (Bovine) - TMPRSS15 gene Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Indicus|evm.model.CM009491.1.122 Q9H9P2 CHODL_HUMAN 97.070 0.992701 1.00366 CHODL - Chondrolectin precursor - Homo sapiens (Human) - CHODL gene May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance. Indicus|evm.model.CM009491.1.123 Q9NYK6 EURL_HUMAN 89.562 0.980132 1.01684 EURL - Protein EURL homolog - Homo sapiens (Human) - EURL gene Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway. Indicus|evm.model.CM009491.1.124 A4UTQ2 BTG3_PIG 96.825 0.992095 1.00397 BTG3 - Protein BTG3 - Sus scrofa (Pig) - BTG3 gene Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase. Indicus|evm.model.CM009491.1.125 Q8WMV3 CXAR_BOVIN 100.000 0.994536 1.00274 CXADR - Coxsackievirus and adenovirus receptor homolog precursor - Bos taurus (Bovine) - CXADR gene Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair (By similarity). Indicus|evm.model.CM009491.1.126 Q9Z222 B3GN2_MOUSE 90.728 0.914634 0.413098 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Mus musculus (Mouse) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains (PubMed:9892646). Probably constitutes the main polylactosamine synthase (PubMed:17890318). Indicus|evm.model.CM009491.1.129 Q9UHP3 UBP25_HUMAN 94.424 0.953791 0.8 USP25 - Ubiquitin carboxyl-terminal hydrolase 25 - Homo sapiens (Human) - USP25 gene Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. Indicus|evm.model.CM009491.1.130 P48552 NRIP1_HUMAN 87.824 0.998271 0.999136 NRIP1 - Nuclear receptor-interacting protein 1 - Homo sapiens (Human) - NRIP1 gene Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). Indicus|evm.model.CM009491.1.131 Q9NSI8 SAMN1_HUMAN 85.791 0.99455 0.983914 SAMSN1 - SAM domain-containing protein SAMSN-1 - Homo sapiens (Human) - SAMSN1 gene Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). Indicus|evm.model.CM009491.1.132 Q2TBX4 HSP13_BOVIN 99.786 0.995726 0.993631 HSPA13 - Heat shock 70 kDa protein 13 precursor - Bos taurus (Bovine) - HSPA13 gene Has peptide-independent ATPase activity. Indicus|evm.model.CM009491.1.133 P33527 MRP1_HUMAN 48.057 0.982226 0.845199 ABCC1 - Multidrug resistance-associated protein 1 - Homo sapiens (Human) - ABCC1 gene Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity). Indicus|evm.model.CM009491.1.134 Q80YT9 RBM11_MOUSE 74.894 0.947368 1.03782 Rbm11 - Splicing regulator RBM11 - Mus musculus (Mouse) - Rbm11 gene Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 (By similarity). Indicus|evm.model.CM009491.1.135 O46415 FRIL_BOVIN 90.286 0.987952 0.948571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009491.1.138 Q9Y6N7 ROBO1_HUMAN 97.121 0.988235 0.978195 ROBO1 - Roundabout homolog 1 precursor - Homo sapiens (Human) - ROBO1 gene Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). Indicus|evm.model.CM009491.1.142 Q32PA9 FKBP2_BOVIN 89.209 0.945205 1.04286 FKBP2 - Peptidyl-prolyl cis-trans isomerase FKBP2 precursor - Bos taurus (Bovine) - FKBP2 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Indicus|evm.model.CM009491.1.143 Q6T308 GLGB_FELCA 87.431 0.986139 0.722461 GBE1 - 1,4-alpha-glucan-branching enzyme - Felis catus (Cat) - GBE1 gene Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule. Indicus|evm.model.CM009491.1.145 P62755 RS6_RAT 69.231 0.943396 0.212851 Rps6 - 40S ribosomal protein S6 - Rattus norvegicus (Rat) - Rps6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009491.1.147 Q6F5E8 CARL2_HUMAN 80.952 0.980392 0.0710801 CARMIL2 - Capping protein, Arp2/3 and myosin-I linker protein 2 - Homo sapiens (Human) - CARMIL2 gene Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647349, PubMed:27647348, PubMed:28112205). Indicus|evm.model.CM009491.1.150 Q8N3J6 CADM2_HUMAN 88.927 0.922078 0.708046 CADM2 - Cell adhesion molecule 2 precursor - Homo sapiens (Human) - CADM2 gene Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. Indicus|evm.model.CM009491.1.151 Q9ESG8 ZDH16_MOUSE 87.302 0.578704 0.598338 Zdhhc16 - Palmitoyltransferase ZDHHC16 - Mus musculus (Mouse) - Zdhhc16 gene Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:26644582). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (PubMed:26644582). Also required for eye development (PubMed:26644582). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (PubMed:27159997). May be involved in apoptosis regulation (PubMed:12021275). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). Indicus|evm.model.CM009491.1.153 Q3SX42 CHM2B_BOVIN 100.000 0.990654 1.00469 CHMP2B - Charged multivesicular body protein 2b - Bos taurus (Bovine) - CHMP2B gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). Indicus|evm.model.CM009491.1.154 P10036 PIT1_BOVIN 91.167 0.993711 1.09278 POU1F1 - Pituitary-specific positive transcription factor 1 - Bos taurus (Bovine) - POU1F1 gene Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. Indicus|evm.model.CM009491.1.155 P30939 5HT1F_HUMAN 94.809 0.99455 1.00273 HTR1F - 5-hydroxytryptamine receptor 1F - Homo sapiens (Human) - HTR1F gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Indicus|evm.model.CM009491.1.156 Q9UFW8 CGBP1_HUMAN 100.000 0.988095 1.00599 CGGBP1 - CGG triplet repeat-binding protein 1 - Homo sapiens (Human) - CGGBP1 gene Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. Indicus|evm.model.CM009491.1.157 Q8IZM8 ZN654_HUMAN 90.722 0.513705 1.94664 ZNF654 - Zinc finger protein 654 - Homo sapiens (Human) - ZNF654 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009491.1.158 Q0VCL9 CC038_BOVIN 99.681 0.993631 1.00319 Uncharacterized protein C3orf38 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009491.1.159 A0A1B0GTH6 CS2IP_HUMAN 58.728 0.986226 0.989101 CSNKA2IP - Casein kinase II subunit alpha'-interacting protein - Homo sapiens (Human) - CSNKA2IP gene May play a role in chromatin regulation of male germ cells. Indicus|evm.model.CM009491.1.160 P29320 EPHA3_HUMAN 98.990 0.933649 0.214649 EPHA3 - Ephrin type-A receptor 3 precursor - Homo sapiens (Human) - EPHA3 gene Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. Indicus|evm.model.CM009491.1.161 P29320 EPHA3_HUMAN 83.714 0.996661 0.609359 EPHA3 - Ephrin type-A receptor 3 precursor - Homo sapiens (Human) - EPHA3 gene Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. Indicus|evm.model.CM009491.1.162 P07224 PROS_BOVIN 99.704 0.997041 1.00148 PROS1 - Vitamin K-dependent protein S precursor - Bos taurus (Bovine) - PROS1 gene Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Indicus|evm.model.CM009491.1.163 Q3SXY8 AR13B_HUMAN 88.140 0.995349 1.00467 ARL13B - ADP-ribosylation factor-like protein 13B - Homo sapiens (Human) - ARL13B gene Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidence is required to confirm these data. Indicus|evm.model.CM009491.1.164 Q0P5D8 NSUN3_BOVIN 100.000 0.9941 1.00296 NSUN3 - tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial - Bos taurus (Bovine) - NSUN3 gene Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation. Indicus|evm.model.CM009491.1.165 Q8VCD7 KDM4C_MOUSE 80.645 0.252101 0.112903 Kdm4c - Lysine-specific demethylase 4C - Mus musculus (Mouse) - Kdm4c gene Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Indicus|evm.model.CM009491.1.167 P68370 TBA1A_RAT 96.674 0.984683 1.0133 Tuba1a - Tubulin alpha-1A chain - Rattus norvegicus (Rat) - Tuba1a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009491.1.168 Q9UF33 EPHA6_HUMAN 97.482 0.734748 0.3639 EPHA6 - Ephrin type-A receptor 6 precursor - Homo sapiens (Human) - EPHA6 gene Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). Indicus|evm.model.CM009491.1.169 Q9UF33 EPHA6_HUMAN 97.666 0.994633 0.539575 EPHA6 - Ephrin type-A receptor 6 precursor - Homo sapiens (Human) - EPHA6 gene Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). Indicus|evm.model.CM009491.1.170 Q0IIM2 ARL6_BOVIN 99.462 0.989305 1.00538 ARL6 - ADP-ribosylation factor-like protein 6 - Bos taurus (Bovine) - ARL6 gene Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization (By similarity). Indicus|evm.model.CM009491.1.171 Q80W49 CRBG3_MOUSE 82.213 0.347452 2.88955 Crybg3 - Beta/gamma crystallin domain-containing protein 3 - Mus musculus (Mouse) - Crybg3 gene protein-containing complex, protein kinase A binding, structural constituent of eye lens, lens development in camera-type eye, visual perception Indicus|evm.model.CM009491.1.172 Q5EA24 RIOX2_BOVIN 99.784 0.99568 1.00216 RIOX2 - Ribosomal oxygenase 2 - Bos taurus (Bovine) - RIOX2 gene Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles (By similarity). Indicus|evm.model.CM009491.1.173 P50573 GBRR3_RAT 83.974 0.995736 1.01078 Gabrr3 - Gamma-aminobutyric acid receptor subunit rho-3 precursor - Rattus norvegicus (Rat) - Gabrr3 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Indicus|evm.model.CM009491.1.176 P0C628 O5AC1_HUMAN 76.712 0.993174 0.954397 OR5AC1 - Olfactory receptor 5AC1 - Homo sapiens (Human) - OR5AC1 gene Odorant receptor. Indicus|evm.model.CM009491.1.180 A6NET4 OR5K3_HUMAN 75.532 0.989362 0.292835 OR5K3 - Olfactory receptor 5K3 - Homo sapiens (Human) - OR5K3 gene Odorant receptor. Indicus|evm.model.CM009491.1.184 Q8NGV7 OR5H2_HUMAN 79.851 0.985185 0.429936 OR5H2 - Olfactory receptor 5H2 - Homo sapiens (Human) - OR5H2 gene Odorant receptor. Indicus|evm.model.CM009491.1.185 Q8VEX6 OL187_MOUSE 78.431 0.961538 0.168831 Olfr187 - Olfactory receptor 187 - Mus musculus (Mouse) - Olfr187 gene Potential odorant receptor. Indicus|evm.model.CM009491.1.187 A6NET4 OR5K3_HUMAN 74.359 0.891473 0.401869 OR5K3 - Olfactory receptor 5K3 - Homo sapiens (Human) - OR5K3 gene Odorant receptor. Indicus|evm.model.CM009491.1.189 Q5RDV7 CLDN1_PONAB 94.862 0.909747 1.09486 CLDND1 - Claudin domain-containing protein 1 - Pongo abelii (Sumatran orangutan) - CLDND1 gene Indicus|evm.model.CM009491.1.190 O97663 GPR15_MACMU 86.111 0.983471 1.00833 GPR15 - G-protein coupled receptor 15 - Macaca mulatta (Rhesus macaque) - GPR15 gene Probable chemokine receptor. SIV-1 coreceptor. Indicus|evm.model.CM009491.1.191 P36551 HEM6_HUMAN 85.872 0.993333 0.991189 CPOX - Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor - Homo sapiens (Human) - CPOX gene Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. Indicus|evm.model.CM009491.1.194 Q6H8M7 SIA10_BOVIN 100.000 0.993976 1.00302 ST3GAL6 - Type 2 lactosamine alpha-2,3-sialyltransferase - Bos taurus (Bovine) - ST3GAL6 gene Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity). Indicus|evm.model.CM009491.1.195 Q96PD2 DCBD2_HUMAN 91.142 0.997436 1.00645 DCBLD2 - Discoidin, CUB and LCCL domain-containing protein 2 precursor - Homo sapiens (Human) - DCBLD2 gene cell surface, integral component of plasma membrane, intracellular receptor signaling pathway, negative regulation of cell growth, wound healing Indicus|evm.model.CM009491.1.197 P14282 CO8A1_RABIT 94.362 0.997319 1.00269 COL8A1 - Collagen alpha-1(VIII) chain precursor - Oryctolagus cuniculus (Rabbit) - COL8A1 gene Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). Indicus|evm.model.CM009491.1.198 Q4L180 FIL1L_HUMAN 94.714 0.978858 0.83348 FILIP1L - Filamin A-interacting protein 1-like - Homo sapiens (Human) - FILIP1L gene Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. Indicus|evm.model.CM009491.1.199 Q4L180 FIL1L_HUMAN 84.653 0.814815 0.214097 FILIP1L - Filamin A-interacting protein 1-like - Homo sapiens (Human) - FILIP1L gene Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. Indicus|evm.model.CM009491.1.200 Q2T9Y1 CC026_BOVIN 89.922 0.844203 0.989247 Uncharacterized protein C3orf26 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009491.1.201 Q2T9P5 CC50C_BOVIN 99.708 0.994186 1.00292 TMEM30C - Cell cycle control protein 50C - Bos taurus (Bovine) - TMEM30C gene endoplasmic reticulum, Golgi apparatus, plasma membrane, phospholipid translocation Indicus|evm.model.CM009491.1.202 Q9NUY8 TBC23_HUMAN 97.000 0.997147 1.00286 TBC1D23 - TBC1 domain family member 23 - Homo sapiens (Human) - TBC1D23 gene Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). Indicus|evm.model.CM009491.1.203 Q2T9R6 NIT2_BOVIN 98.913 0.96831 1.02899 NIT2 - Omega-amidase NIT2 - Bos taurus (Bovine) - NIT2 gene Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively. Indicus|evm.model.CM009491.1.204 O94826 TOM70_HUMAN 95.731 0.996721 1.00329 TOMM70 - Mitochondrial import receptor subunit TOM70 - Homo sapiens (Human) - TOMM70 gene Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812). Indicus|evm.model.CM009491.1.205 A1A4G5 LNP1_HUMAN 75.141 0.977778 1.01124 LNP1 - Leukemia NUP98 fusion partner 1 - Homo sapiens (Human) - LNP1 gene Indicus|evm.model.CM009491.1.206 Q9NWC5 TM45A_HUMAN 65.283 0.956522 1.00364 TMEM45A - Transmembrane protein 45A - Homo sapiens (Human) - TMEM45A gene Indicus|evm.model.CM009491.1.207 Q8N7U6 EFHB_HUMAN 73.621 0.939323 1.02881 EFHB - EF-hand domain-containing family member B - Homo sapiens (Human) - EFHB gene Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. Indicus|evm.model.CM009491.1.208 Q0IIG7 RAB5A_BOVIN 100.000 0.984496 0.6 RAB5A - Ras-related protein Rab-5A - Bos taurus (Bovine) - RAB5A gene Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16476778) (By similarity). RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3. Indicus|evm.model.CM009491.1.209 A8MPX8 PP2D1_HUMAN 61.792 0.995261 1.00476 PP2D1 - Protein phosphatase 2C-like domain-containing protein 1 - Homo sapiens (Human) - PP2D1 gene protein serine/threonine phosphatase activity, protein dephosphorylation Indicus|evm.model.CM009491.1.210 A2RRP1 NBAS_HUMAN 86.166 0.745562 0.142556 NBAS - Neuroblastoma-amplified sequence - Homo sapiens (Human) - NBAS gene Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Indicus|evm.model.CM009491.1.212 Q92831 KAT2B_HUMAN 96.175 0.987838 0.889423 KAT2B - Histone acetyltransferase KAT2B - Homo sapiens (Human) - KAT2B gene Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (PubMed:8945521). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (PubMed:8945521). Also acetylates non-histone proteins, such as ACLY, PLK4, RRP9/U3-55K and TBX5 (PubMed:9707565, PubMed:10675335, PubMed:27796307, PubMed:23932781, PubMed:26867678, PubMed:29174768). Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A (PubMed:8684459). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing (PubMed:26867678). Also acetylates spermidine (PubMed:27389534). Indicus|evm.model.CM009491.1.213 Q5FBB7 SGO1_HUMAN 62.547 0.899824 1.01426 SGO1 - Shugoshin 1 - Homo sapiens (Human) - SGO1 gene Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. Indicus|evm.model.CM009491.1.214 Q9NQW5 PRDM7_HUMAN 76.630 0.851508 0.876016 PRDM7 - Probable histone-lysine N-methyltransferase PRDM7 - Homo sapiens (Human) - PRDM7 gene Probable histone methyltransferase. Indicus|evm.model.CM009491.1.216 Q8TC21 ZN596_HUMAN 72.603 0.971429 1.04167 ZNF596 - Zinc finger protein 596 - Homo sapiens (Human) - ZNF596 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009491.1.217 Q9SLC4 ATL40_ARATH 50.794 0.423611 0.663594 ATL40 - RING-H2 finger protein ATL40 - Arabidopsis thaliana (Mouse-ear cress) - ATL40 gene Indicus|evm.model.CM009491.1.219 Q9NWC5 TM45A_HUMAN 73.585 0.956522 1.00364 TMEM45A - Transmembrane protein 45A - Homo sapiens (Human) - TMEM45A gene Indicus|evm.model.CM009491.1.220 Q96K78 AGRG7_HUMAN 74.948 0.953722 0.623588 ADGRG7 - Adhesion G-protein coupled receptor G7 precursor - Homo sapiens (Human) - ADGRG7 gene Orphan receptor. Indicus|evm.model.CM009491.1.221 Q92734 TFG_HUMAN 94.763 0.995025 1.005 TFG - Protein TFG - Homo sapiens (Human) - TFG gene Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). Indicus|evm.model.CM009491.1.222 Q7Z7G0 TARSH_HUMAN 78.219 0.380376 1.53581 ABI3BP - Target of Nesh-SH3 precursor - Homo sapiens (Human) - ABI3BP gene collagen-containing extracellular matrix, extracellular region, extracellular space Indicus|evm.model.CM009491.1.224 A6NC97 F172B_HUMAN 85.359 0.975543 1.01657 FAM172BP - Putative protein FAM172B - Homo sapiens (Human) - FAM172BP gene nucleus, heterochromatin assembly by small RNA Indicus|evm.model.CM009491.1.225 Q2KI45 TM10C_BOVIN 100.000 0.995316 1.00235 TRMT10C - tRNA methyltransferase 10 homolog C precursor - Bos taurus (Bovine) - TRMT10C gene Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. Indicus|evm.model.CM009491.1.226 Q32PF3 PCNP_BOVIN 100.000 0.885 1.1236 PCNP - PEST proteolytic signal-containing nuclear protein - Bos taurus (Bovine) - PCNP gene May be involved in cell cycle regulation. Indicus|evm.model.CM009491.1.227 O95625 ZBT11_HUMAN 92.220 0.998101 1 ZBTB11 - Zinc finger and BTB domain-containing protein 11 - Homo sapiens (Human) - ZBTB11 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009491.1.228 P83732 RL24_RAT 100.000 0.987342 1.00637 Rpl24 - 60S ribosomal protein L24 - Rattus norvegicus (Rat) - Rpl24 gene cytoplasm, cytosolic large ribosomal subunit, cytosolic ribosome, polysomal ribosome, synapse, RNA binding, structural constituent of ribosome, assembly of large subunit precursor of preribosome, cytoplasmic translation, exit from mitosis Indicus|evm.model.CM009491.1.229 Q8IW35 CEP97_HUMAN 83.968 0.997672 0.993064 CEP97 - Centrosomal protein of 97 kDa - Homo sapiens (Human) - CEP97 gene Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome. Indicus|evm.model.CM009491.1.231 A2VDP6 NXPE3_BOVIN 100.000 0.996429 1.00179 NXPE3 - NXPE family member 3 precursor - Bos taurus (Bovine) - NXPE3 gene Indicus|evm.model.CM009491.1.232 Q9BE45 IKBZ_BOVIN 100.000 0.997222 1.00139 NFKBIZ - NF-kappa-B inhibitor zeta - Bos taurus (Bovine) - NFKBIZ gene Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity). Indicus|evm.model.CM009491.1.233 Q9D2P4 URM1_MOUSE 73.585 0.6125 0.792079 Urm1 - Ubiquitin-related modifier 1 - Mus musculus (Mouse) - Urm1 gene Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. Indicus|evm.model.CM009491.1.234 P24049 RL17_RAT 82.609 0.764045 0.483696 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009491.1.236 Q8TCW7 ZPLD1_HUMAN 90.661 0.992188 0.616867 ZPLD1 - Zona pellucida-like domain-containing protein 1 precursor - Homo sapiens (Human) - ZPLD1 gene Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ. Indicus|evm.model.CM009491.1.238 Q13191 CBLB_HUMAN 97.152 0.964637 1.03666 CBLB - E3 ubiquitin-protein ligase CBL-B - Homo sapiens (Human) - CBLB gene E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). Indicus|evm.model.CM009491.1.239 O46414 FRIH_BOVIN 67.857 0.886179 0.679558 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009491.1.240 Q29RU3 CCD54_BOVIN 99.695 0.993921 1.00305 CCDC54 - Coiled-coil domain-containing protein 54 - Bos taurus (Bovine) - CCDC54 gene Indicus|evm.model.CM009491.1.241 Q8WY36 BBX_HUMAN 93.418 0.99157 1.0085 BBX - HMG box transcription factor BBX - Homo sapiens (Human) - BBX gene Transcription factor that is necessary for cell cycle progression from G1 to S phase. Indicus|evm.model.CM009491.1.242 Q9N0K1 CD47_BOVIN 99.010 0.993421 1.0033 CD47 - Leukocyte surface antigen CD47 precursor - Bos taurus (Bovine) - CD47 gene Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection (By similarity). Indicus|evm.model.CM009491.1.243 Q5EA95 IFT57_BOVIN 99.767 0.995349 1.00233 IFT57 - Intraflagellar transport protein 57 homolog - Bos taurus (Bovine) - IFT57 gene Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear (By similarity). Indicus|evm.model.CM009491.1.244 Q9UM44 HHLA2_HUMAN 58.696 0.910112 1.07488 HHLA2 - HERV-H LTR-associating protein 2 precursor - Homo sapiens (Human) - HHLA2 gene Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. Indicus|evm.model.CM009491.1.245 Q9Y2K3 MYH15_HUMAN 80.624 0.894078 1.06732 MYH15 - Myosin-15 - Homo sapiens (Human) - MYH15 gene Muscle contraction. Indicus|evm.model.CM009491.1.246 Q9BW19 KIFC1_HUMAN 64.033 0.908309 0.518574 KIFC1 - Kinesin-like protein KIFC1 - Homo sapiens (Human) - KIFC1 gene Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). Indicus|evm.model.CM009491.1.247 Q8TCG1 CIP2A_HUMAN 89.537 0.99776 0.98674 CIP2A - Protein CIP2A - Homo sapiens (Human) - CIP2A gene Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation. Indicus|evm.model.CM009491.1.248 Q86Y13 DZIP3_HUMAN 88.411 0.998342 0.998344 DZIP3 - E3 ubiquitin-protein ligase DZIP3 - Homo sapiens (Human) - DZIP3 gene E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. Indicus|evm.model.CM009491.1.249 Q3SYX1 TRAT1_BOVIN 99.482 0.989691 1.00518 TRAT1 - T-cell receptor-associated transmembrane adapter 1 - Bos taurus (Bovine) - TRAT1 gene Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. Indicus|evm.model.CM009491.1.250 Q86VD1 MORC1_HUMAN 68.210 0.997655 0.86687 MORC1 - MORC family CW-type zinc finger protein 1 - Homo sapiens (Human) - MORC1 gene Required for spermatogenesis (By similarity). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity). Indicus|evm.model.CM009491.1.252 Q7L190 DPPA4_HUMAN 72.881 0.140436 1.35855 DPPA4 - Developmental pluripotency-associated protein 4 - Homo sapiens (Human) - DPPA4 gene May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage. Indicus|evm.model.CM009491.1.253 A8D8X1 RL10_SHEEP 98.598 0.63964 1.55607 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009491.1.254 Q3SZU4 CDO1_BOVIN 97.561 0.655738 0.305 CDO1 - Cysteine dioxygenase type 1 - Bos taurus (Bovine) - CDO1 gene cysteine dioxygenase activity, ferrous iron binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, L-cysteine catabolic process Indicus|evm.model.CM009491.1.255 Q5RKI1 IF4A2_RAT 96.865 0.99375 0.786241 Eif4a2 - Eukaryotic initiation factor 4A-II - Rattus norvegicus (Rat) - Eif4a2 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Indicus|evm.model.CM009491.1.257 Q9NQS3 NECT3_HUMAN 97.980 0.995968 0.903461 NECTIN3 - Nectin-3 precursor - Homo sapiens (Human) - NECTIN3 gene Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. Indicus|evm.model.CM009491.1.259 Q3MHP9 TACT_BOVIN 94.561 0.99633 0.95614 CD96 - T-cell surface protein tactile precursor - Bos taurus (Bovine) - CD96 gene May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity). Indicus|evm.model.CM009491.1.260 Q3B820 F161A_HUMAN 89.091 0.872 0.189394 FAM161A - Protein FAM161A - Homo sapiens (Human) - FAM161A gene Involved in ciliogenesis. Indicus|evm.model.CM009491.1.261 B2RXA1 PLCX2_MOUSE 92.032 0.992063 0.741176 Plcxd2 - PI-PLC X domain-containing protein 2 - Mus musculus (Mouse) - Plcxd2 gene Indicus|evm.model.CM009491.1.262 Q86SQ0 PHLB2_HUMAN 90.670 0.977379 1.02314 PHLDB2 - Pleckstrin homology-like domain family B member 2 - Homo sapiens (Human) - PHLDB2 gene Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). Indicus|evm.model.CM009491.1.263 Q5E9H9 ABHDA_BOVIN 99.346 0.993485 1.00327 ABHD10 - Palmitoyl-protein thioesterase ABHD10, mitochondrial precursor - Bos taurus (Bovine) - ABHD10 gene Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate. Indicus|evm.model.CM009491.1.264 Q3ZBY2 TAGL3_BOVIN 100.000 0.156275 6.36683 TAGLN3 - Transgelin-3 - Bos taurus (Bovine) - TAGLN3 gene Indicus|evm.model.CM009491.1.265 Q8N6F7 GCSAM_HUMAN 69.832 0.988827 1.00562 GCSAM - Germinal center-associated signaling and motility protein - Homo sapiens (Human) - GCSAM gene Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. Indicus|evm.model.CM009491.1.266 Q4G0N8 SL9C1_HUMAN 71.518 0.914403 1.03229 SLC9C1 - Sodium/hydrogen exchanger 10 - Homo sapiens (Human) - SLC9C1 gene Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). Indicus|evm.model.CM009491.1.267 P41217 OX2G_HUMAN 79.026 0.985075 0.964029 CD200 - OX-2 membrane glycoprotein precursor - Homo sapiens (Human) - CD200 gene Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. Indicus|evm.model.CM009491.1.268 Q7Z6A9 BTLA_HUMAN 57.818 0.989051 0.948097 BTLA - B- and T-lymphocyte attenuator precursor - Homo sapiens (Human) - BTLA gene Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044). Indicus|evm.model.CM009491.1.269 Q0VCL3 ATG3_BOVIN 100.000 0.993651 1.00318 ATG3 - Ubiquitin-like-conjugating enzyme ATG3 - Bos taurus (Bovine) - ATG3 gene E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway (By similarity). Indicus|evm.model.CM009491.1.270 A6QPI1 S35A5_BOVIN 99.765 0.867076 1.15059 SLC35A5 - Probable UDP-sugar transporter protein SLC35A5 - Bos taurus (Bovine) - SLC35A5 gene integral component of Golgi membrane Indicus|evm.model.CM009491.1.271 Q76M96 CCD80_HUMAN 85.893 0.997906 1.00526 CCDC80 - Coiled-coil domain-containing protein 80 precursor - Homo sapiens (Human) - CCDC80 gene Promotes cell adhesion and matrix assembly. Indicus|evm.model.CM009491.1.272 A5D7V5 MO2R1_BOVIN 95.152 0.911111 0.507042 CD200R1 - Cell surface glycoprotein CD200 receptor 1 precursor - Bos taurus (Bovine) - CD200R1 gene Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli (By similarity). Indicus|evm.model.CM009491.1.273 A5D7V5 MO2R1_BOVIN 99.155 0.994382 1.00282 CD200R1 - Cell surface glycoprotein CD200 receptor 1 precursor - Bos taurus (Bovine) - CD200R1 gene Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli (By similarity). Indicus|evm.model.CM009491.1.274 Q0P5E7 GTPB8_BOVIN 100.000 0.899654 1.00347 GTPBP8 - GTP-binding protein 8 - Bos taurus (Bovine) - GTPBP8 gene mitochondrion Indicus|evm.model.CM009491.1.275 Q6NW34 NEPRO_HUMAN 80.389 0.996448 0.992945 NEPRO - Nucleolus and neural progenitor protein - Homo sapiens (Human) - NEPRO gene May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development. Indicus|evm.model.CM009491.1.276 P25787 PSA2_HUMAN 100.000 0.991489 1.00427 PSMA2 - Proteasome subunit alpha type-2 - Homo sapiens (Human) - PSMA2 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Indicus|evm.model.CM009491.1.277 Q9BWV1 BOC_HUMAN 89.068 0.998209 1.00269 BOC - Brother of CDO precursor - Homo sapiens (Human) - BOC gene Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Indicus|evm.model.CM009491.1.278 Q96MT7 CFA44_HUMAN 82.280 0.971068 1.02535 CFAP44 - Cilia- and flagella-associated protein 44 - Homo sapiens (Human) - CFAP44 gene Flagellar protein involved in sperm flagellum axoneme organization and function. Indicus|evm.model.CM009491.1.279 Q2T9X8 SPICE_BOVIN 99.535 0.997677 1.00116 SPICE1 - Spindle and centriole-associated protein 1 - Bos taurus (Bovine) - SPICE1 gene Regulator required for centriole duplication. for proper bipolar spindle formation and chromosome congression in mitosis (By similarity). Indicus|evm.model.CM009491.1.280 Q9NXL6 SIDT1_HUMAN 91.563 0.976942 0.996372 SIDT1 - SID1 transmembrane family member 1 precursor - Homo sapiens (Human) - SIDT1 gene In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Indicus|evm.model.CM009491.1.281 Q68DE3 USF3_HUMAN 87.100 0.879542 1.12784 USF3 - Basic helix-loop-helix domain-containing protein USF3 - Homo sapiens (Human) - USF3 gene Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties. Indicus|evm.model.CM009491.1.282 Q5RF28 NAA50_PONAB 100.000 0.988235 1.00592 NAA50 - N-alpha-acetyltransferase 50 - Pongo abelii (Sumatran orangutan) - NAA50 gene N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. Component of a N-alpha-acetyltransferase complex containing NAA10 and NAA15, but NAA50 does not influence the acetyltransferase activity of NAA10: this multiprotein complex probably constitutes the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides. Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10. Indicus|evm.model.CM009491.1.283 P31404 VATA_BOVIN 100.000 0.995153 1.00324 ATP6V1A - V-type proton ATPase catalytic subunit A - Bos taurus (Bovine) - ATP6V1A gene Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity). Indicus|evm.model.CM009491.1.284 P68105 EF1A1_RABIT 91.633 0.325033 1.65152 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009491.1.286 Q8IYP9 ZDH23_HUMAN 89.000 0.927907 1.05134 ZDHHC23 - Palmitoyltransferase ZDHHC23 - Homo sapiens (Human) - ZDHHC23 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. Indicus|evm.model.CM009491.1.287 Q8NCU4 CC191_HUMAN 78.798 0.993435 0.976496 CCDC191 - Coiled-coil domain-containing protein 191 - Homo sapiens (Human) - CCDC191 gene Indicus|evm.model.CM009491.1.288 Q9H974 QTRT2_HUMAN 91.566 0.995192 1.00241 QTRT2 - Queuine tRNA-ribosyltransferase accessory subunit 2 - Homo sapiens (Human) - QTRT2 gene Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Indicus|evm.model.CM009491.1.289 P52703 DRD3_CHLAE 90.250 0.995012 1.0025 DRD3 - D(3) dopamine receptor - Chlorocebus aethiops (Green monkey) - DRD3 gene Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity). Indicus|evm.model.CM009491.1.290 Q495A1 TIGIT_HUMAN 64.777 0.991803 1 TIGIT - T-cell immunoreceptor with Ig and ITIM domains precursor - Homo sapiens (Human) - TIGIT gene Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Indicus|evm.model.CM009491.1.291 Q9HC78 ZBT20_HUMAN 97.973 0.908979 1.09717 ZBTB20 - Zinc finger and BTB domain-containing protein 20 - Homo sapiens (Human) - ZBTB20 gene May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). Indicus|evm.model.CM009491.1.292 Q3SYR7 RL9_BOVIN 89.583 0.988764 0.927083 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009491.1.293 P06836 NEUM_BOVIN 99.569 0.987179 0.966942 GAP43 - Neuromodulin - Bos taurus (Bovine) - GAP43 gene This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). Indicus|evm.model.CM009491.1.295 P52898 DDBX_BOVIN 88.732 0.907051 0.965944 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009491.1.296 Q3T062 RRP15_BOVIN 96.552 0.770053 0.653846 RRP15 - RRP15-like protein - Bos taurus (Bovine) - RRP15 gene preribosome, large subunit precursor, maturation of 5.8S rRNA, maturation of LSU-rRNA Indicus|evm.model.CM009491.1.298 Q08DK1 IGS11_BOVIN 99.771 0.995434 1.00229 IGSF11 - Immunoglobulin superfamily member 11 precursor - Bos taurus (Bovine) - IGSF11 gene Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity). Indicus|evm.model.CM009491.1.300 Q96M34 TEX55_HUMAN 39.591 0.898167 0.916045 TEX55 - Testis-specific expressed protein 55 - Homo sapiens (Human) - TEX55 gene nucleus Indicus|evm.model.CM009491.1.301 P38573 UPK1B_BOVIN 99.615 0.824841 1.20769 UPK1B - Uroplakin-1b - Bos taurus (Bovine) - UPK1B gene Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. Indicus|evm.model.CM009491.1.302 O60513 B4GT4_HUMAN 84.164 0.985507 1.00291 B4GALT4 - Beta-1,4-galactosyltransferase 4 - Homo sapiens (Human) - B4GALT4 gene Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Indicus|evm.model.CM009491.1.303 Q2M1Z3 RHG31_HUMAN 82.951 0.957219 1.03601 ARHGAP31 - Rho GTPase-activating protein 31 - Homo sapiens (Human) - ARHGAP31 gene Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. Indicus|evm.model.CM009491.1.304 Q0VCF5 TM39A_BOVIN 99.793 0.789819 1.24795 TMEM39A - Transmembrane protein 39A - Bos taurus (Bovine) - TMEM39A gene Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (By similarity). Indicus|evm.model.CM009491.1.305 Q5E9Q1 PGLT1_BOVIN 100.000 0.994911 1.00255 POGLUT1 - Protein O-glucosyltransferase 1 precursor - Bos taurus (Bovine) - POGLUT1 gene Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (By similarity). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (By similarity). Notch glucosylation does not affect Notch ligand binding (By similarity). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity). Indicus|evm.model.CM009491.1.306 Q9NPL8 TIDC1_HUMAN 69.474 0.992278 0.908772 TIMMDC1 - Complex I assembly factor TIMMDC1, mitochondrial - Homo sapiens (Human) - TIMMDC1 gene Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I. Indicus|evm.model.CM009491.1.307 P33681 CD80_HUMAN 62.605 0.630319 1.30556 CD80 - T-lymphocyte activation antigen CD80 precursor - Homo sapiens (Human) - CD80 gene Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. Indicus|evm.model.CM009491.1.308 Q32KR8 ADPRH_BOVIN 99.717 0.99435 1.00283 ADPRH - [Protein ADP-ribosylarginine] hydrolase - Bos taurus (Bovine) - ADPRH gene Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. Indicus|evm.model.CM009491.1.309 Q5E9H0 PLA1A_BOVIN 100.000 0.924797 1.07895 PLA1A - Phospholipase A1 member A precursor - Bos taurus (Bovine) - PLA1A gene Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. Indicus|evm.model.CM009491.1.310 Q9HBU9 POPD2_HUMAN 80.912 0.948509 1.01374 POPDC2 - Popeye domain-containing protein 2 - Homo sapiens (Human) - POPDC2 gene Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Indicus|evm.model.CM009491.1.311 Q6J3Q7 COX17_CANLF 84.615 0.5 1.20635 COX17 - Cytochrome c oxidase copper chaperone - Canis lupus familiaris (Dog) - COX17 gene Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). Indicus|evm.model.CM009491.1.312 Q95LR0 CFA91_MACFA 83.312 0.997386 0.997392 CFAP91 - Cilia- and flagella-associated protein 91 - Macaca fascicularis (Crab-eating macaque) - CFAP91 gene May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). May play a role in spermatogenesis (By similarity). Indicus|evm.model.CM009491.1.313 Q8SQ01 NR1I2_MACMU 82.217 0.925054 1.07604 NR1I2 - Nuclear receptor subfamily 1 group I member 2 - Macaca mulatta (Rhesus macaque) - NR1I2 gene Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Indicus|evm.model.CM009491.1.314 Q5YJC2 GSK3B_SPECI 88.281 0.976923 0.309524 GSK3B - Glycogen synthase kinase-3 beta - Spermophilus citellus (European suslik) - GSK3B gene Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity (By similarity). Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SFPQ upon T-cell activation. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2 (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (By similarity). Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (By similarity). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity (By similarity). The complex composed, at least, of APC, CTNNB1 and GSK3B interacts with JPT1; the interaction requires the inactive form of GSK3B (phosphorylated at 'Ser-9') (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (By similarity). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Indicus|evm.model.CM009491.1.315 P49841 GSK3B_HUMAN 98.381 0.828283 0.707143 GSK3B - Glycogen synthase kinase-3 beta - Homo sapiens (Human) - GSK3B gene Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and ARNTL/BMLA1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110). Indicus|evm.model.CM009491.1.317 Q8NFN8 GP156_HUMAN 76.223 0.997253 0.894349 GPR156 - Probable G-protein coupled receptor 156 - Homo sapiens (Human) - GPR156 gene Orphan receptor. Indicus|evm.model.CM009491.1.318 Q99879 H2B1M_HUMAN 93.458 0.854839 0.984127 H2BC14 - Histone H2B type 1-M - Homo sapiens (Human) - H2BC14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009491.1.319 Q96CX6 LRC58_HUMAN 96.496 0.994624 1.0027 LRRC58 - Leucine-rich repeat-containing protein 58 - Homo sapiens (Human) - LRRC58 gene Indicus|evm.model.CM009491.1.321 Q58D84 FSTL1_BOVIN 100.000 0.993506 1.00326 FSTL1 - Follistatin-related protein 1 precursor - Bos taurus (Bovine) - FSTL1 gene Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity). Indicus|evm.model.CM009491.1.322 P48305 NDUB4_BOVIN 99.225 0.984615 1.00775 NDUFB4 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 - Bos taurus (Bovine) - NDUFB4 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009491.1.323 Q93099 HGD_HUMAN 94.344 0.657228 1.50787 HGD - Homogentisate 1,2-dioxygenase - Homo sapiens (Human) - HGD gene cytoplasm, cytosol, extracellular exosome, homogentisate 1,2-dioxygenase activity, identical protein binding, L-phenylalanine catabolic process, tyrosine catabolic process Indicus|evm.model.CM009491.1.324 A6QLI8 T2EA_BOVIN 100.000 0.719064 0.682648 GTF2E1 - General transcription factor IIE subunit 1 - Bos taurus (Bovine) - GTF2E1 gene Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Indicus|evm.model.CM009491.1.325 A6QLI8 T2EA_BOVIN 96.875 0.746479 0.486301 GTF2E1 - General transcription factor IIE subunit 1 - Bos taurus (Bovine) - GTF2E1 gene Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Indicus|evm.model.CM009491.1.326 Q9Y2K9 STB5L_HUMAN 91.062 0.998225 0.950253 STXBP5L - Syntaxin-binding protein 5-like - Homo sapiens (Human) - STXBP5L gene Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045). Indicus|evm.model.CM009491.1.327 O75417 DPOLQ_HUMAN 79.785 0.999229 1.00154 POLQ - DNA polymerase theta - Homo sapiens (Human) - POLQ gene DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323). POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963). POLQ-mediated MMEJ may be required to promote the survival of cells with a compromised HR repair pathway, thereby preventing genomic havoc by resolving unrepaired lesions (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-paired region using the opposing overhang as a template. Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323). The polymerase activity is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). Also exhibits low-fidelity DNA synthesis, translesion synthesis and lyase activity, and it is implicated in interstrand-cross-link repair, base excision repair and DNA end-joining (PubMed:14576298, PubMed:18503084, PubMed:19188258, PubMed:24648516). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). Indicus|evm.model.CM009491.1.328 A6NJG6 ARGFX_HUMAN 60.177 0.84375 0.406349 ARGFX - Arginine-fifty homeobox - Homo sapiens (Human) - ARGFX gene Putative transcription factor. Indicus|evm.model.CM009491.1.329 Q9UH90 FBX40_HUMAN 87.395 0.994406 1.00846 FBXO40 - F-box only protein 40 - Homo sapiens (Human) - FBXO40 gene Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis. Indicus|evm.model.CM009491.1.330 P14317 HCLS1_HUMAN 86.531 0.995885 1 HCLS1 - Hematopoietic lineage cell-specific protein - Homo sapiens (Human) - HCLS1 gene Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. Indicus|evm.model.CM009491.1.331 Q14789 GOGB1_HUMAN 84.733 0.988221 1.01596 GOLGB1 - Golgin subfamily B member 1 - Homo sapiens (Human) - GOLGB1 gene May participate in forming intercisternal cross-bridges of the Golgi complex. Indicus|evm.model.CM009491.1.332 Q8BP00 IQCB1_MOUSE 87.291 0.996661 1.00167 Iqcb1 - IQ calmodulin-binding motif-containing protein 1 - Mus musculus (Mouse) - Iqcb1 gene Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (By similarity). Indicus|evm.model.CM009491.1.333 Q96CJ1 EAF2_HUMAN 87.072 0.992395 1.01154 EAF2 - ELL-associated factor 2 - Homo sapiens (Human) - EAF2 gene Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo. Indicus|evm.model.CM009491.1.334 Q16348 S15A2_HUMAN 87.517 0.99726 1.00137 SLC15A2 - Solute carrier family 15 member 2 - Homo sapiens (Human) - SLC15A2 gene Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356, PubMed:18367661). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Probably acts by mediating transport of bacterial peptidoglycans across the plasma membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). Indicus|evm.model.CM009491.1.335 Q16348 S15A2_HUMAN 70.861 0.653199 0.814815 SLC15A2 - Solute carrier family 15 member 2 - Homo sapiens (Human) - SLC15A2 gene Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356, PubMed:18367661). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Probably acts by mediating transport of bacterial peptidoglycans across the plasma membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). Indicus|evm.model.CM009491.1.336 Q5R8C7 ILDR1_PONAB 82.847 0.990926 1.00916 ILDR1 - Immunoglobulin-like domain-containing receptor 1 precursor - Pongo abelii (Sumatran orangutan) - ILDR1 gene Putative membrane receptor. Indicus|evm.model.CM009491.1.337 P42081 CD86_HUMAN 55.718 0.9941 1.0304 CD86 - T-lymphocyte activation antigen CD86 precursor - Homo sapiens (Human) - CD86 gene Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). Indicus|evm.model.CM009491.1.338 P19525 E2AK2_HUMAN 65.657 0.915094 0.192377 EIF2AK2 - Interferon-induced, double-stranded RNA-activated protein kinase - Homo sapiens (Human) - EIF2AK2 gene IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19507191, PubMed:19189853, PubMed:21123651, PubMed:21072047, PubMed:22948139, PubMed:23229543, PubMed:22381929). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:20171114, PubMed:19840259, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:22214662, PubMed:19229320). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). Indicus|evm.model.CM009491.1.339 P35384 CASR_BOVIN 99.724 0.998158 1.00092 CASR - Extracellular calcium-sensing receptor precursor - Bos taurus (Bovine) - CASR gene G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:8255296). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8255296). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (By similarity). Indicus|evm.model.CM009491.1.340 Q9D8T7 SLIRP_MOUSE 67.532 0.730769 0.928571 Slirp - SRA stem-loop-interacting RNA-binding protein, mitochondrial precursor - Mus musculus (Mouse) - Slirp gene RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity). Indicus|evm.model.CM009491.1.341 P80416 CYTA_BOVIN 97.959 0.979798 1.0102 CSTA - Cystatin-A - Bos taurus (Bovine) - CSTA gene This is an intracellular thiol proteinase inhibitor. Indicus|evm.model.CM009491.1.342 A4FUI1 MIX23_BOVIN 100.000 0.98374 0.854167 MIX23 - Protein MIX23 - Bos taurus (Bovine) - MIX23 gene Indicus|evm.model.CM009491.1.343 Q2NKR7 F162A_BOVIN 100.000 0.837209 1.10256 FAM162A - Protein FAM162A - Bos taurus (Bovine) - FAM162A gene Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. Indicus|evm.model.CM009491.1.344 Q86VZ2 WDR5B_HUMAN 91.212 0.8225 1.21212 WDR5B - WD repeat-containing protein 5B - Homo sapiens (Human) - WDR5B gene May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex. Indicus|evm.model.CM009491.1.345 A2VE08 IMA5_BOVIN 100.000 0.996289 1.00186 KPNA1 - Importin subunit alpha-5 - Bos taurus (Bovine) - KPNA1 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Indicus|evm.model.CM009491.1.346 Q8IXQ6 PARP9_HUMAN 64.163 0.978022 0.959016 PARP9 - Protein mono-ADP-ribosyltransferase PARP9 - Homo sapiens (Human) - PARP9 gene ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity (PubMed:28525742). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300). Indicus|evm.model.CM009491.1.347 Q8TDB6 DTX3L_HUMAN 64.075 0.997297 1 DTX3L - E3 ubiquitin-protein ligase DTX3L - Homo sapiens (Human) - DTX3L gene E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788). Indicus|evm.model.CM009491.1.348 Q460N5 PAR14_HUMAN 70.588 0.997222 0.999445 PARP14 - Protein mono-ADP-ribosyltransferase PARP14 - Homo sapiens (Human) - PARP14 gene ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:27796300, PubMed:18851833, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300). Indicus|evm.model.CM009491.1.349 Q58CU3 HBAP1_BOVIN 99.793 0.995876 1.00207 HSPBAP1 - HSPB1-associated protein 1 - Bos taurus (Bovine) - HSPBAP1 gene May play a role in cellular stress response. Indicus|evm.model.CM009491.1.350 Q8BFQ6 DIRC2_MOUSE 80.753 0.995238 0.878661 Slc49a4 - Solute carrier family 49 member 4 - Mus musculus (Mouse) - Slc49a4 gene Electrogenic metabolite transporter. Indicus|evm.model.CM009491.1.351 Q9P283 SEM5B_HUMAN 94.053 0.99816 0.944396 SEMA5B - Semaphorin-5B - Homo sapiens (Human) - SEMA5B gene May act as positive axonal guidance cues. Indicus|evm.model.CM009491.1.353 Q2KIL5 PDIA5_BOVIN 100.000 0.996169 1.00192 PDIA5 - Protein disulfide-isomerase A5 precursor - Bos taurus (Bovine) - PDIA5 gene Indicus|evm.model.CM009491.1.354 Q8BH47 SC22A_MOUSE 96.347 0.900826 0.788274 Sec22a - Vesicle-trafficking protein SEC22a - Mus musculus (Mouse) - Sec22a gene May be involved in vesicle transport between the ER and the Golgi complex. Indicus|evm.model.CM009491.1.355 O95622 ADCY5_HUMAN 94.847 0.943993 0.877875 ADCY5 - Adenylate cyclase type 5 - Homo sapiens (Human) - ADCY5 gene Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). Indicus|evm.model.CM009491.1.356 Q2KIP8 HACD2_BOVIN 99.213 0.992157 1.00394 HACD2 - Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 - Bos taurus (Bovine) - HACD2 gene Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Indicus|evm.model.CM009491.1.357 P70081 H48_CHICK 97.590 0.645669 1.23301 H4-VIII - Histone H4 type VIII - Gallus gallus (Chicken) - H4-VIII gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009491.1.358 Q28824 MYLK_BOVIN 100.000 0.340415 1.72109 MYLK - Myosin light chain kinase, smooth muscle - Bos taurus (Bovine) - MYLK gene Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells (By similarity). Indicus|evm.model.CM009491.1.359 Q49A88 CCD14_HUMAN 73.822 0.997877 0.988458 CCDC14 - Coiled-coil domain-containing protein 14 - Homo sapiens (Human) - CCDC14 gene Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. Indicus|evm.model.CM009491.1.360 Q3T064 ROP1_BOVIN 99.528 0.99061 1.00472 ROPN1 - Ropporin-1 - Bos taurus (Bovine) - ROPN1 gene Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. Indicus|evm.model.CM009491.1.361 A2CG49 KALRN_MOUSE 97.990 0.980797 0.474359 Kalrn - Kalirin - Mus musculus (Mouse) - Kalrn gene Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity). Indicus|evm.model.CM009491.1.362 P97924 KALRN_RAT 92.157 0.554945 0.0615073 Kalrn - Kalirin - Rattus norvegicus (Rat) - Kalrn gene Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation. Indicus|evm.model.CM009491.1.363 O60229 KALRN_HUMAN 96.734 0.998235 0.379437 KALRN - Kalirin - Homo sapiens (Human) - KALRN gene Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Indicus|evm.model.CM009491.1.364 P31754 UMPS_BOVIN 99.792 0.995842 1.00208 UMPS - Uridine 5'-monophosphate synthase - Bos taurus (Bovine) - UMPS gene Indicus|evm.model.CM009491.1.365 P80747 ITB5_BOVIN 99.866 0.934919 0.99875 ITGB5 - Integrin beta-5 precursor - Bos taurus (Bovine) - ITGB5 gene Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Indicus|evm.model.CM009491.1.366 Q9H3R2 MUC13_HUMAN 48.594 0.802632 1.1875 MUC13 - Mucin-13 precursor - Homo sapiens (Human) - MUC13 gene Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling. Indicus|evm.model.CM009491.1.367 Q9ULI3 HEG1_HUMAN 69.839 0.574697 1.07603 HEG1 - Protein HEG homolog 1 precursor - Homo sapiens (Human) - HEG1 gene Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. Indicus|evm.model.CM009491.1.368 A0AV02 S12A8_HUMAN 82.073 0.997122 0.973389 SLC12A8 - Solute carrier family 12 member 8 - Homo sapiens (Human) - SLC12A8 gene Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. Indicus|evm.model.CM009491.1.369 Q3Y4E1 ZN148_BOVIN 99.874 0.997484 1.00126 ZNF148 - Zinc finger protein 148 - Bos taurus (Bovine) - ZNF148 gene Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes (By similarity). Indicus|evm.model.CM009491.1.370 A1A4L0 SNX4_BOVIN 100.000 0.900415 1.07111 SNX4 - Sorting nexin-4 - Bos taurus (Bovine) - SNX4 gene Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Indicus|evm.model.CM009491.1.371 Q9BXB4 OSB11_HUMAN 94.149 0.98946 1.01606 OSBPL11 - Oxysterol-binding protein-related protein 11 - Homo sapiens (Human) - OSBPL11 gene Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Indicus|evm.model.CM009491.1.372 Q9R0Q3 TMED2_MOUSE 93.956 0.89604 1.00498 Tmed2 - Transmembrane emp24 domain-containing protein 2 precursor - Mus musculus (Mouse) - Tmed2 gene Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity). Required for morphogenesis of embryo and placenta. Indicus|evm.model.CM009491.1.373 Q8BMN4 LMLN_MOUSE 89.474 0.942685 0.973568 Lmln - Leishmanolysin-like peptidase - Mus musculus (Mouse) - Lmln gene Metalloprotease. Indicus|evm.model.CM009491.1.374 Q56JY1 RL35A_BOVIN 100.000 0.981982 1.00909 RPL35A - 60S ribosomal protein L35a - Bos taurus (Bovine) - RPL35A gene Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation (By similarity). The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (By similarity). Indicus|evm.model.CM009491.1.375 Q2T9V2 DRC9_BOVIN 99.771 0.995434 1.00229 IQCG - Dynein regulatory complex protein 9 - Bos taurus (Bovine) - IQCG gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. Indicus|evm.model.CM009491.1.376 Q96II8 LRCH3_HUMAN 90.104 0.980645 0.997426 LRCH3 - DISP complex protein LRCH3 - Homo sapiens (Human) - LRCH3 gene As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Indicus|evm.model.CM009491.1.377 Q17QU6 UIF_BOVIN 100.000 0.99373 1.00314 FYTTD1 - UAP56-interacting factor - Bos taurus (Bovine) - FYTTD1 gene Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 (By similarity). Indicus|evm.model.CM009491.1.378 Q92622 RUBIC_HUMAN 90.206 0.979757 1.01646 RUBCN - Run domain Beclin-1-interacting and cysteine-rich domain-containing protein - Homo sapiens (Human) - RUBCN gene Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). Indicus|evm.model.CM009491.1.380 Q99102 MUC4_HUMAN 66.576 0.942623 0.506224 MUC4 - Mucin-4 precursor - Homo sapiens (Human) - MUC4 gene May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Indicus|evm.model.CM009491.1.381 Q17R13 ACK1_BOVIN 98.102 0.968721 1.0462 TNK2 - Activated CDC42 kinase 1 - Bos taurus (Bovine) - TNK2 gene Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR (By similarity). Indicus|evm.model.CM009491.1.382 Q8HZV3 TFR1_PIG 79.156 0.977151 0.96875 TFRC - Transferrin receptor protein 1 - Sus scrofa (Pig) - TFRC gene Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity). Indicus|evm.model.CM009491.1.383 Q8WVZ1 ZDH19_HUMAN 84.000 0.776623 1.24595 ZDHHC19 - Palmitoyltransferase ZDHHC19 - Homo sapiens (Human) - ZDHHC19 gene Palmitoyltransferase that mediates palmitoylation of RRAS, leading to increased cell viability. Indicus|evm.model.CM009491.1.384 Q3T124 OSTA_BOVIN 100.000 0.994135 1.00294 SLC51A - Organic solute transporter subunit alpha - Bos taurus (Bovine) - SLC51A gene Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity). Indicus|evm.model.CM009491.1.385 P49585 PCY1A_HUMAN 96.458 0.994565 1.00272 PCYT1A - Choline-phosphate cytidylyltransferase A - Homo sapiens (Human) - PCYT1A gene Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. Indicus|evm.model.CM009491.1.386 Q32P71 DYT2B_BOVIN 79.581 0.519126 2.40789 DYNLT2B - Dynein light chain Tctex-type protein 2B - Bos taurus (Bovine) - DYNLT2B gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. Required for proper retrograde ciliary transport. Indicus|evm.model.CM009491.1.387 Q96DZ7 T4S19_HUMAN 84.158 0.990148 0.971292 TM4SF19 - Transmembrane 4 L6 family member 19 - Homo sapiens (Human) - TM4SF19 gene integral component of membrane Indicus|evm.model.CM009491.1.388 Q5REY7 UBXN7_PONAB 97.751 0.995918 1.00204 UBXN7 - UBX domain-containing protein 7 - Pongo abelii (Sumatran orangutan) - UBXN7 gene Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity). Indicus|evm.model.CM009491.1.389 Q0IIM1 RN168_BOVIN 99.825 0.996516 1.00175 RNF168 - E3 ubiquitin-protein ligase RNF168 - Bos taurus (Bovine) - RNF168 gene E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). Indicus|evm.model.CM009491.1.390 Q147U7 SMCO1_HUMAN 80.841 0.990698 1.00467 SMCO1 - Single-pass membrane and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - SMCO1 gene Indicus|evm.model.CM009491.1.391 Q32KQ2 WDR53_BOVIN 100.000 0.936047 0.480447 WDR53 - WD repeat-containing protein 53 - Bos taurus (Bovine) - WDR53 gene Indicus|evm.model.CM009491.1.392 P0C2W1 FBSP1_HUMAN 100.000 0.890071 0.986014 FBXO45 - F-box/SPRY domain-containing protein 1 - Homo sapiens (Human) - FBXO45 gene Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. Indicus|evm.model.CM009491.1.393 Q3ZBI5 LRC33_BOVIN 100.000 0.997114 1.00145 NRROS - Transforming growth factor beta activator LRRC33 precursor - Bos taurus (Bovine) - NRROS gene Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling. Indicus|evm.model.CM009491.1.394 A6H7C9 CEP19_BOVIN 100.000 0.987805 1.00613 CEP19 - Centrosomal protein of 19 kDa - Bos taurus (Bovine) - CEP19 gene Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes. Indicus|evm.model.CM009491.1.395 Q8TBF5 PIGX_HUMAN 70.612 0.655914 1.44186 PIGX - Phosphatidylinositol-glycan biosynthesis class X protein precursor - Homo sapiens (Human) - PIGX gene Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity). Indicus|evm.model.CM009491.1.396 O46415 FRIL_BOVIN 90.323 0.960938 0.731429 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009491.1.397 Q64303 PAK2_RAT 91.794 0.995902 0.931298 Pak2 - Serine/threonine-protein kinase PAK 2 - Rattus norvegicus (Rat) - Pak2 gene Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity). Indicus|evm.model.CM009491.1.398 Q96HI0 SENP5_HUMAN 89.007 0.997351 1 SENP5 - Sentrin-specific protease 5 - Homo sapiens (Human) - SENP5 gene Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Indicus|evm.model.CM009491.1.399 P52298 NCBP2_HUMAN 100.000 0.987261 1.00641 NCBP2 - Nuclear cap-binding protein subunit 2 - Homo sapiens (Human) - NCBP2 gene Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858). Indicus|evm.model.CM009491.1.400 Q69YL0 NCAS2_HUMAN 85.714 0.97 1.0101 NCBP2AS2 - Protein NCBP2AS2 - Homo sapiens (Human) - NCBP2AS2 gene Indicus|evm.model.CM009491.1.401 Q86VD9 PIGZ_HUMAN 78.707 0.880872 1.02936 PIGZ - GPI mannosyltransferase 4 - Homo sapiens (Human) - PIGZ gene Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues. Indicus|evm.model.CM009491.1.402 P08582 TRFM_HUMAN 90.999 0.959459 1.00271 MELTF - Melanotransferrin precursor - Homo sapiens (Human) - MELTF gene Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. Indicus|evm.model.CM009491.1.403 Q28C55 DLG1_XENTR 83.965 0.440986 0.831715 dlg1 - Disks large homolog 1 - Xenopus tropicalis (Western clawed frog) - dlg1 gene Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction and cell proliferation (By similarity). Indicus|evm.model.CM009491.1.404 Q3SYR7 RL9_BOVIN 97.917 0.989583 1 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009491.1.405 Q02337 BDH_BOVIN 100.000 0.994203 1.00291 BDH1 - D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - BDH1 gene matrix side of mitochondrial inner membrane, 3-hydroxybutyrate dehydrogenase activity Indicus|evm.model.CM009491.1.406 Q32KY0 APOD_BOVIN 98.942 0.882629 1.12698 APOD - Apolipoprotein D precursor - Bos taurus (Bovine) - APOD gene APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts (By similarity). Indicus|evm.model.CM009491.1.407 Q3SZX2 IPP2_BOVIN 99.034 0.990385 1.00483 PPP1R2 - Protein phosphatase inhibitor 2 - Bos taurus (Bovine) - PPP1R2 gene Inhibitor of protein-phosphatase 1. Indicus|evm.model.CM009491.1.408 Q4R8C7 AIDA_MACFA 97.000 0.7 0.509091 AIDA - Axin interactor, dorsalization-associated protein - Macaca fascicularis (Crab-eating macaque) - AIDA gene Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). Indicus|evm.model.CM009491.1.409 Q15057 ACAP2_HUMAN 97.686 0.997433 1.00129 ACAP2 - Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 - Homo sapiens (Human) - ACAP2 gene GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Indicus|evm.model.CM009491.1.410 Q8NBI6 XXLT1_HUMAN 96.774 0.821429 0.284987 XXYLT1 - Xyloside xylosyltransferase 1 - Homo sapiens (Human) - XXYLT1 gene Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869). Indicus|evm.model.CM009491.1.411 Q3U4G3 XXLT1_MOUSE 94.222 0.937238 0.609694 Xxylt1 - Xyloside xylosyltransferase 1 - Mus musculus (Mouse) - Xxylt1 gene Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose. Known targets include Notch proteins and coagulation factors, such as F9. Indicus|evm.model.CM009491.1.413 Q8N2R8 FA43A_HUMAN 93.381 0.995283 1.00236 FAM43A - Protein FAM43A - Homo sapiens (Human) - FAM43A gene Indicus|evm.model.CM009491.1.414 Q2YDM7 LSG1_BOVIN 97.428 0.995455 1.01227 LSG1 - Large subunit GTPase 1 homolog - Bos taurus (Bovine) - LSG1 gene GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity). Indicus|evm.model.CM009491.1.415 Q2T9K0 TMM44_HUMAN 69.309 0.986667 0.947368 TMEM44 - Transmembrane protein 44 - Homo sapiens (Human) - TMEM44 gene Indicus|evm.model.CM009491.1.416 Q95JN5 AT133_MACFA 90.244 0.378566 2.63618 ATP13A3 - Polyamine-transporting ATPase 13A3 - Macaca fascicularis (Crab-eating macaque) - ATP13A3 gene ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol. Indicus|evm.model.CM009491.1.417 P40197 GPV_HUMAN 72.842 0.975926 0.964286 GP5 - Platelet glycoprotein V precursor - Homo sapiens (Human) - GP5 gene The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. Indicus|evm.model.CM009491.1.418 Q8TF66 LRC15_HUMAN 86.403 0.991453 1.00688 LRRC15 - Leucine-rich repeat-containing protein 15 precursor - Homo sapiens (Human) - LRRC15 gene extracellular exosome, extracellular matrix, extracellular space, collagen binding, fibronectin binding, laminin binding, negative regulation of protein localization to plasma membrane, positive regulation of cell migration, receptor-mediated virion attachment to host cell Indicus|evm.model.CM009491.1.419 P22792 CPN2_HUMAN 75.730 0.996357 1.00734 CPN2 - Carboxypeptidase N subunit 2 precursor - Homo sapiens (Human) - CPN2 gene The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit. Indicus|evm.model.CM009491.1.422 Q3ZBG4 HES1_BOVIN 100.000 0.712838 1.05714 HES1 - Transcription factor HES-1 - Bos taurus (Bovine) - HES1 gene Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). Indicus|evm.model.CM009491.1.423 O60313 OPA1_HUMAN 92.118 0.998031 1.05833 OPA1 - Dynamin-like 120 kDa protein, mitochondrial precursor - Homo sapiens (Human) - OPA1 gene Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317). Indicus|evm.model.CM009491.1.424 Q4VNC1 AT134_HUMAN 89.112 0.995826 1.00167 ATP13A4 - Probable cation-transporting ATPase 13A4 - Homo sapiens (Human) - ATP13A4 gene plasma membrane, cellular calcium ion homeostasis, ion transmembrane transport Indicus|evm.model.CM009491.1.425 Q4VNC0 AT135_HUMAN 76.536 0.577922 0.252874 ATP13A5 - Probable cation-transporting ATPase 13A5 - Homo sapiens (Human) - ATP13A5 gene plasma membrane, cellular calcium ion homeostasis, ion transmembrane transport Indicus|evm.model.CM009491.1.426 Q4VNC0 AT135_HUMAN 79.337 0.924672 0.752053 ATP13A5 - Probable cation-transporting ATPase 13A5 - Homo sapiens (Human) - ATP13A5 gene plasma membrane, cellular calcium ion homeostasis, ion transmembrane transport Indicus|evm.model.CM009491.1.428 Q9HDD0 PLAT1_HUMAN 85.207 0.879581 1.1369 PLAAT1 - Phospholipase A and acyltransferase 1 - Homo sapiens (Human) - PLAAT1 gene Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:21880860, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:21880860, PubMed:22825852, PubMed:27623847). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:21880860). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (PubMed:21880860, PubMed:22825852, PubMed:27623847). Indicus|evm.model.CM009491.1.429 Q8IYB1 M21D2_HUMAN 93.333 0.91358 0.164969 MB21D2 - Protein MB21D2 - Homo sapiens (Human) - MB21D2 gene cadherin binding, protein-containing complex binding Indicus|evm.model.CM009491.1.430 Q8IYB1 M21D2_HUMAN 100.000 0.941573 0.906314 MB21D2 - Protein MB21D2 - Homo sapiens (Human) - MB21D2 gene cadherin binding, protein-containing complex binding Indicus|evm.model.CM009491.1.431 P61150 FGF12_RAT 100.000 0.934211 0.312757 Fgf12 - Fibroblast growth factor 12 - Rattus norvegicus (Rat) - Fgf12 gene Involved in nervous system development and function. Promote neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. Indicus|evm.model.CM009491.1.433 Q8IVM0 CCD50_HUMAN 85.465 0.354772 1.57516 CCDC50 - Coiled-coil domain-containing protein 50 - Homo sapiens (Human) - CCDC50 gene Involved in EGFR signaling. Indicus|evm.model.CM009491.1.434 P61366 OSTN_HUMAN 90.977 0.963235 1.02256 OSTN - Osteocrin precursor - Homo sapiens (Human) - OSTN gene Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity). Indicus|evm.model.CM009491.1.435 Q99877 H2B1N_HUMAN 94.737 0.520833 1.14286 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009491.1.436 A6NCL1 GEMC1_HUMAN 87.126 0.994012 1 GMNC - Geminin coiled-coil domain-containing protein 1 - Homo sapiens (Human) - GMNC gene Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity). Indicus|evm.model.CM009491.1.437 P68105 EF1A1_RABIT 87.013 0.99568 1.00216 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009491.1.438 P62752 RL23A_RAT 100.000 0.978102 0.878205 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009491.1.439 Q9NPH3 IL1AP_HUMAN 76.720 0.819242 1.20351 IL1RAP - Interleukin-1 receptor accessory protein precursor - Homo sapiens (Human) - IL1RAP gene Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). Indicus|evm.model.CM009491.1.440 Q6UWW9 TM207_HUMAN 68.794 0.913333 1.0274 TMEM207 - Transmembrane protein 207 precursor - Homo sapiens (Human) - TMEM207 gene Indicus|evm.model.CM009491.1.441 Q9XT98 CLD16_BOVIN 100.000 0.720798 1.38189 CLDN16 - Claudin-16 - Bos taurus (Bovine) - CLDN16 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity). Indicus|evm.model.CM009491.1.442 Q6L708 CLD1_BOVIN 100.000 0.990566 1.00474 CLDN1 - Claudin-1 - Bos taurus (Bovine) - CLDN1 gene Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (By similarity). Indicus|evm.model.CM009491.1.444 Q8IVL5 P3H2_HUMAN 92.655 0.997171 0.998588 P3H2 - Prolyl 3-hydroxylase 2 precursor - Homo sapiens (Human) - P3H2 gene Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:18487197). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1 (PubMed:18487197). Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline (PubMed:18487197). Has no activity on substrates that lack 4-hydroxyproline in the third position (PubMed:18487197). Indicus|evm.model.CM009491.1.445 O88898 P63_MOUSE 99.126 0.972743 0.863235 Tp63 - Tumor protein 63 - Mus musculus (Mouse) - Tp63 gene Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Indicus|evm.model.CM009491.1.446 Q9JJP6 P63_RAT 98.551 0.790698 0.126471 Tp63 - Tumor protein 63 - Rattus norvegicus (Rat) - Tp63 gene Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter (By similarity). Indicus|evm.model.CM009491.1.447 Q6ZUI0 TPRG1_HUMAN 92.174 0.982759 0.421818 TPRG1 - Tumor protein p63-regulated gene 1 protein - Homo sapiens (Human) - TPRG1 gene cytoplasm Indicus|evm.model.CM009491.1.452 P41182 BCL6_HUMAN 95.042 0.997171 1.00142 BCL6 - B-cell lymphoma 6 protein - Homo sapiens (Human) - BCL6 gene Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. Indicus|evm.model.CM009491.1.453 Q5QGT7 RTP2_HUMAN 90.667 0.991071 0.995556 RTP2 - Receptor-transporting protein 2 - Homo sapiens (Human) - RTP2 gene Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs. Indicus|evm.model.CM009491.1.454 O46688 SMS_SHEEP 100.000 0.982906 1.00862 SST - Somatostatin precursor - Ovis aries (Sheep) - SST gene Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. Indicus|evm.model.CM009491.1.455 Q96DX8 RTP4_HUMAN 62.150 0.367491 2.30081 RTP4 - Receptor-transporting protein 4 - Homo sapiens (Human) - RTP4 gene Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). Indicus|evm.model.CM009491.1.456 P48740 MASP1_HUMAN 81.102 0.258163 1.402 MASP1 - Mannan-binding lectin serine protease 1 precursor - Homo sapiens (Human) - MASP1 gene Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343). Indicus|evm.model.CM009491.1.457 Q95JK0 RTP1_MACFA 94.273 0.991228 0.86692 RTP1 - Receptor-transporting protein 1 - Macaca fascicularis (Crab-eating macaque) - RTP1 gene Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs. Indicus|evm.model.CM009491.1.458 P15907 SIAT1_HUMAN 82.555 0.903371 1.09606 ST6GAL1 - Beta-galactoside alpha-2,6-sialyltransferase 1 - Homo sapiens (Human) - ST6GAL1 gene Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. Indicus|evm.model.CM009491.1.459 O95772 STR3N_HUMAN 92.340 0.991525 1.00855 STARD3NL - STARD3 N-terminal-like protein - Homo sapiens (Human) - STARD3NL gene Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). Indicus|evm.model.CM009491.1.460 Q3Y5Z3 ADIPO_BOVIN 100.000 0.991701 1.00417 ADIPOQ - Adiponectin precursor - Bos taurus (Bovine) - ADIPOQ gene Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW (By similarity). Indicus|evm.model.CM009491.1.461 P35249 RFC4_HUMAN 95.604 0.817568 1.22314 RFC4 - Replication factor C subunit 4 - Homo sapiens (Human) - RFC4 gene The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template. Indicus|evm.model.CM009491.1.462 Q5RKI1 IF4A2_RAT 100.000 0.995098 1.00246 Eif4a2 - Eukaryotic initiation factor 4A-II - Rattus norvegicus (Rat) - Eif4a2 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Indicus|evm.model.CM009491.1.463 P01045 KNG2_BOVIN 99.192 0.996774 1.00162 KNG2 - Kininogen-2 precursor - Bos taurus (Bovine) - KNG2 gene (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. Indicus|evm.model.CM009491.1.464 P33433 HRG_BOVIN 85.950 0.223464 1.35606 HRG - Histidine-rich glycoprotein - Bos taurus (Bovine) - HRG gene Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity). Indicus|evm.model.CM009491.1.465 Q58D62 FETUB_BOVIN 99.225 0.994845 1.00258 FETUB - Fetuin-B precursor - Bos taurus (Bovine) - FETUB gene Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity). Indicus|evm.model.CM009491.1.466 P12763 FETUA_BOVIN 99.721 0.994444 1.00279 AHSG - Alpha-2-HS-glycoprotein precursor - Bos taurus (Bovine) - AHSG gene Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone. Indicus|evm.model.CM009491.1.467 Q3ZBA6 DJB11_BOVIN 100.000 0.994429 1.00279 DNAJB11 - DnaJ homolog subfamily B member 11 precursor - Bos taurus (Bovine) - DNAJB11 gene As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. Indicus|evm.model.CM009491.1.468 A4IF93 TBCC1_BOVIN 99.641 0.996416 1.0018 TBCCD1 - TBCC domain-containing protein 1 - Bos taurus (Bovine) - TBCCD1 gene Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration. Indicus|evm.model.CM009491.1.469 P06504 CRYGS_BOVIN 100.000 0.988827 1.00562 CRYGS - Gamma-crystallin S - Bos taurus (Bovine) - CRYGS gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009491.1.471 P49619 DGKG_HUMAN 91.909 0.997475 1.00126 DGKG - Diacylglycerol kinase gamma - Homo sapiens (Human) - DGKG gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity). Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597). Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity). Indicus|evm.model.CM009491.1.472 P41161 ETV5_HUMAN 93.738 0.995951 0.968627 ETV5 - ETS translocation variant 5 - Homo sapiens (Human) - ETV5 gene Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. Indicus|evm.model.CM009491.1.473 Q0VCN1 NMRL1_BOVIN 46.847 0.932203 0.394649 NMRAL1 - NmrA-like family domain-containing protein 1 - Bos taurus (Bovine) - NMRAL1 gene Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer (By similarity). Indicus|evm.model.CM009491.1.474 Q0VCN1 NMRL1_BOVIN 61.417 0.984375 0.428094 NMRAL1 - NmrA-like family domain-containing protein 1 - Bos taurus (Bovine) - NMRAL1 gene Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer (By similarity). Indicus|evm.model.CM009491.1.475 P62997 TRA2B_RAT 100.000 0.99308 1.00347 Tra2b - Transformer-2 protein homolog beta - Rattus norvegicus (Rat) - Tra2b gene Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity). Indicus|evm.model.CM009491.1.476 Q9Y6M1 IF2B2_HUMAN 98.497 0.996667 1.00167 IGF2BP2 - Insulin-like growth factor 2 mRNA-binding protein 2 - Homo sapiens (Human) - IGF2BP2 gene RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Indicus|evm.model.CM009491.1.477 Q5R7K7 SENP2_PONAB 91.511 0.99661 1.0017 SENP2 - Sentrin-specific protease 2 - Pongo abelii (Sumatran orangutan) - SENP2 gene Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (By similarity). Indicus|evm.model.CM009491.1.478 Q8WWY8 LIPH_HUMAN 86.031 0.982533 1.01552 LIPH - Lipase member H precursor - Homo sapiens (Human) - LIPH gene Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Indicus|evm.model.CM009491.1.479 Q08D99 TM41A_BOVIN 99.621 0.992453 1.00379 TMEM41A - Transmembrane protein 41A precursor - Bos taurus (Bovine) - TMEM41A gene Indicus|evm.model.CM009491.1.480 A7MBB4 M3K13_BOVIN 99.482 0.997932 1.00104 MAP3K13 - Mitogen-activated protein kinase kinase kinase 13 - Bos taurus (Bovine) - MAP3K13 gene Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity). Indicus|evm.model.CM009491.1.481 Q08426 ECHP_HUMAN 82.849 0.997238 1.00138 EHHADH - Peroxisomal bifunctional enzyme - Homo sapiens (Human) - EHHADH gene Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long straight chain fatty acids peroxisomal beta-oxidation pathway. Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species (Probable). Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity). With HSD17B4, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed:15060085). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (PubMed:15060085). Indicus|evm.model.CM009491.1.482 A7E369 CC070_BOVIN 100.000 0.992032 1.004 UPF0524 protein C3orf70 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009491.1.483 Q8N3P4 VPS8_HUMAN 94.724 0.997605 0.584734 VPS8 - Vacuolar protein sorting-associated protein 8 homolog - Homo sapiens (Human) - VPS8 gene Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290). Indicus|evm.model.CM009491.1.484 Q9HAY2 MAGF1_HUMAN 83.333 0.831395 1.12052 MAGEF1 - Melanoma-associated antigen F1 - Homo sapiens (Human) - MAGEF1 gene Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed:29225034). Indicus|evm.model.CM009491.1.486 P54753 EPHB3_HUMAN 98.706 0.997845 0.92986 EPHB3 - Ephrin type-B receptor 3 precursor - Homo sapiens (Human) - EPHB3 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. Indicus|evm.model.CM009491.1.489 Q5EA53 T2FA_BOVIN 64.646 0.858491 0.205029 GTF2F1 - General transcription factor IIF subunit 1 - Bos taurus (Bovine) - GTF2F1 gene TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity). Indicus|evm.model.CM009491.1.491 Q9H2X0 CHRD_HUMAN 91.153 0.939759 0.956021 CHRD - Chordin precursor - Homo sapiens (Human) - CHRD gene Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity). Indicus|evm.model.CM009491.1.492 P42706 TPO_PIG 92.308 0.0706215 13.6154 THPO - Thrombopoietin - Sus scrofa (Pig) - THPO gene Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Indicus|evm.model.CM009491.1.493 Q923G2 RPAB3_MOUSE 100.000 0.986755 1.00667 Polr2h - DNA-directed RNA polymerases I, II, and III subunit RPABC3 - Mus musculus (Mouse) - Polr2h gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity). Indicus|evm.model.CM009491.1.494 P51788 CLCN2_HUMAN 94.507 0.985619 1.00668 CLCN2 - Chloride channel protein 2 - Homo sapiens (Human) - CLCN2 gene Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012). Indicus|evm.model.CM009491.1.495 Q6UXB0 F131A_HUMAN 96.175 0.99455 1.00273 FAM131A - Protein FAM131A - Homo sapiens (Human) - FAM131A gene Indicus|evm.model.CM009491.1.496 Q04637 IF4G1_HUMAN 93.707 0.998751 1.00125 EIF4G1 - Eukaryotic translation initiation factor 4 gamma 1 - Homo sapiens (Human) - EIF4G1 gene Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Indicus|evm.model.CM009491.1.497 P56701 PSMD2_BOVIN 100.000 0.9978 1.0011 PSMD2 - 26S proteasome non-ATPase regulatory subunit 2 - Bos taurus (Bovine) - PSMD2 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Indicus|evm.model.CM009491.1.498 F1N476 ECE2_BOVIN 100.000 0.822563 1.19346 ECE2 - Endothelin-converting enzyme 2 - Bos taurus (Bovine) - ECE2 gene Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides (By similarity). May play a role in amyloid-beta processing (By similarity). Indicus|evm.model.CM009491.1.499 Q92685 ALG3_HUMAN 88.453 0.995652 1.05023 ALG3 - Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase - Homo sapiens (Human) - ALG3 gene Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. Indicus|evm.model.CM009491.1.500 Q8N398 VW5B2_HUMAN 87.490 0.998397 1.00483 VWA5B2 - von Willebrand factor A domain-containing protein 5B2 - Homo sapiens (Human) - VWA5B2 gene Indicus|evm.model.CM009491.1.501 Q9NUQ8 ABCF3_HUMAN 98.307 0.997183 1.00141 ABCF3 - ATP-binding cassette sub-family F member 3 - Homo sapiens (Human) - ABCF3 gene Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. Indicus|evm.model.CM009491.1.502 P84092 AP2M1_RAT 99.540 0.995392 0.997701 Ap2m1 - AP-2 complex subunit mu - Rattus norvegicus (Rat) - Ap2m1 gene Component of the adaptor protein complex 2 (AP-2) (PubMed:14745134, PubMed:15473838). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:14745134, PubMed:15473838). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:14745134, PubMed:15473838). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:14745134, PubMed:15473838). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:14745134, PubMed:15473838). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed:14745134, PubMed:15473838). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed:14745134, PubMed:15473838). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (By similarity). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (PubMed:15985462). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (By similarity). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 mu (AP2M1) subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (PubMed:15985462). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed:15985462, PubMed:11516654). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling (PubMed:20947020). Indicus|evm.model.CM009491.1.503 Q92997 DVL3_HUMAN 98.714 0.494342 1.97486 DVL3 - Segment polarity protein dishevelled homolog DVL-3 - Homo sapiens (Human) - DVL3 gene Involved in the signal transduction pathway mediated by multiple Wnt genes. Indicus|evm.model.CM009491.1.504 A5X5Y0 5HT3E_HUMAN 70.175 0.995434 0.960526 HTR3E - 5-hydroxytryptamine receptor 3E precursor - Homo sapiens (Human) - HTR3E gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Indicus|evm.model.CM009491.1.505 Q8WXA8 5HT3C_HUMAN 74.944 0.995536 1.00224 HTR3C - 5-hydroxytryptamine receptor 3C precursor - Homo sapiens (Human) - HTR3C gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Indicus|evm.model.CM009491.1.506 Q8WXA8 5HT3C_HUMAN 72.368 0.995575 1.01119 HTR3C - 5-hydroxytryptamine receptor 3C precursor - Homo sapiens (Human) - HTR3C gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Indicus|evm.model.CM009491.1.507 O15440 MRP5_HUMAN 95.268 0.998609 1.0007 ABCC5 - Multidrug resistance-associated protein 5 - Homo sapiens (Human) - ABCC5 gene Acts as a multispecific organic anion pump which can transport nucleotide analogs. Heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). Indicus|evm.model.CM009491.1.508 P20821 GCSH_BOVIN 94.203 0.985612 0.803468 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Indicus|evm.model.CM009491.1.510 P62278 RS13_RAT 96.970 0.879195 0.986755 Rps13 - 40S ribosomal protein S13 - Rattus norvegicus (Rat) - Rps13 gene cytosolic small ribosomal subunit, nucleolus, nucleus, postsynaptic density, synapse, 5.8S rRNA binding, mRNA 5'-UTR binding, mRNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome Indicus|evm.model.CM009491.1.511 Q8TAV3 CP2W1_HUMAN 53.571 0.482456 0.232653 CYP2W1 - Cytochrome P450 2W1 precursor - Homo sapiens (Human) - CYP2W1 gene A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism (PubMed:22591743, PubMed:26936974). Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates (PubMed:26936974). Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) (PubMed:22591743). Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids (PubMed:26936974, PubMed:22591743). May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:20805301, PubMed:16551781, PubMed:24278521). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22591743, PubMed:26936974). Indicus|evm.model.CM009491.1.512 Q2KHV4 PARL_BOVIN 99.735 0.994709 1.00265 PARL - Presenilins-associated rhomboid-like protein, mitochondrial precursor - Bos taurus (Bovine) - PARL gene Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). Indicus|evm.model.CM009491.1.513 Q0P591 MA6D1_BOVIN 99.275 0.643192 1.10938 MAP6D1 - MAP6 domain-containing protein 1 - Bos taurus (Bovine) - MAP6D1 gene May have microtubule-stabilizing activity. Indicus|evm.model.CM009491.1.514 Q9ULM3 YETS2_HUMAN 92.842 0.998585 0.993671 YEATS2 - YEATS domain-containing protein 2 - Homo sapiens (Human) - YEATS2 gene Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). Indicus|evm.model.CM009491.1.515 Q5E995 RS6_BOVIN 90.361 0.991453 0.939759 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009491.1.516 Q6TFL4 KLH24_HUMAN 99.667 0.996672 1.00167 KLHL24 - Kelch-like protein 24 - Homo sapiens (Human) - KLHL24 gene Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Indicus|evm.model.CM009491.1.518 Q8WZ60 KLHL6_HUMAN 96.769 0.996774 0.99839 KLHL6 - Kelch-like protein 6 - Homo sapiens (Human) - KLHL6 gene Involved in B-lymphocyte antigen receptor signaling and germinal center formation. Indicus|evm.model.CM009491.1.519 Q4R4Y9 IF4A2_MACFA 69.444 0.215686 0.375 EIF4A2 - Eukaryotic initiation factor 4A-II - Macaca fascicularis (Crab-eating macaque) - EIF4A2 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Indicus|evm.model.CM009491.1.520 Q5E9B1 LDHB_BOVIN 96.407 0.99403 1.00299 LDHB - L-lactate dehydrogenase B chain - Bos taurus (Bovine) - LDHB gene L-lactate dehydrogenase activity Indicus|evm.model.CM009491.1.521 Q86YR7 MF2L2_HUMAN 77.572 0.981168 0.953321 MCF2L2 - Probable guanine nucleotide exchange factor MCF2L2 - Homo sapiens (Human) - MCF2L2 gene Probably functions as a guanine nucleotide exchange factor. Indicus|evm.model.CM009491.1.522 Q9UQV4 LAMP3_HUMAN 66.341 0.94213 1.03846 LAMP3 - Lysosome-associated membrane glycoprotein 3 precursor - Homo sapiens (Human) - LAMP3 gene May play a role in dendritic cell function and in adaptive immunity. Indicus|evm.model.CM009491.1.523 Q96RQ3 MCCA_HUMAN 88.414 0.997245 1.00138 MCCC1 - Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor - Homo sapiens (Human) - MCCC1 gene Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. Indicus|evm.model.CM009491.1.524 Q96GG9 DCNL1_HUMAN 99.612 0.908127 1.09266 DCUN1D1 - DCN1-like protein 1 - Homo sapiens (Human) - DCUN1D1 gene Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:26906416, PubMed:23201271, PubMed:19617556, PubMed:23401859). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). Indicus|evm.model.CM009491.1.525 Q9Y2G3 AT11B_HUMAN 93.628 0.998302 1.00085 ATP11B - Phospholipid-transporting ATPase IF - Homo sapiens (Human) - ATP11B gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). Indicus|evm.model.CM009491.1.527 P54231 SOX2_SHEEP 100.000 0.993769 1.00313 SOX2 - Transcription factor SOX-2 - Ovis aries (Sheep) - SOX2 gene Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). Indicus|evm.model.CM009491.1.530 Q3ZBN8 TIM14_BOVIN 100.000 0.982906 1.00862 DNAJC19 - Mitochondrial import inner membrane translocase subunit TIM14 - Bos taurus (Bovine) - DNAJC19 gene Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). Indicus|evm.model.CM009491.1.531 Q2TBT7 FXR1_BOVIN 99.813 0.987037 0.869565 FXR1 - Fragile X mental retardation syndrome-related protein 1 - Bos taurus (Bovine) - FXR1 gene RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). Indicus|evm.model.CM009491.1.532 E1BM70 CCD39_BOVIN 96.072 0.997877 1 CCDC39 - Coiled-coil domain-containing protein 39 - Bos taurus (Bovine) - CCDC39 gene Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. Indicus|evm.model.CM009491.1.533 Q96N46 TTC14_HUMAN 90.415 0.997409 1.0026 TTC14 - Tetratricopeptide repeat protein 14 - Homo sapiens (Human) - TTC14 gene Indicus|evm.model.CM009491.1.536 Q925N3 PEX5R_RAT 96.179 0.996683 1.00166 Pex5l - PEX5-related protein - Rattus norvegicus (Rat) - Pex5l gene Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. Indicus|evm.model.CM009491.1.537 E1BMF7 UBP13_BOVIN 100.000 0.997685 1.00116 USP13 - Ubiquitin carboxyl-terminal hydrolase 13 - Bos taurus (Bovine) - USP13 gene Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data. Indicus|evm.model.CM009491.1.538 Q02380 NDUB5_BOVIN 100.000 0.989474 1.00529 NDUFB5 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor - Bos taurus (Bovine) - NDUFB5 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009491.1.539 Q08DT6 RM47_BOVIN 98.810 0.992095 1.00397 MRPL47 - 39S ribosomal protein L47, mitochondrial precursor - Bos taurus (Bovine) - MRPL47 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Indicus|evm.model.CM009491.1.540 O96019 ACL6A_HUMAN 99.534 0.995349 1.00233 ACTL6A - Actin-like protein 6A - Homo sapiens (Human) - ACTL6A gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Indicus|evm.model.CM009491.1.541 Q9HAV0 GBB4_HUMAN 95.882 0.993902 0.964706 GNB4 - Guanine nucleotide-binding protein subunit beta-4 - Homo sapiens (Human) - GNB4 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009491.1.542 Q811U4 MFN1_MOUSE 94.054 0.994616 1.0027 Mfn1 - Mitofusin-1 - Mus musculus (Mouse) - Mfn1 gene Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23921378, PubMed:24513856, PubMed:15297672). Membrane clustering requires GTPase activity (By similarity). It may involve a major rearrangement of the coiled coil domains (PubMed:15297672). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12527753). Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity (By similarity). Indicus|evm.model.CM009491.1.543 A5PK30 ZN639_BOVIN 99.794 0.995885 1.00206 ZNF639 - Zinc finger protein 639 - Bos taurus (Bovine) - ZNF639 gene Binds DNA and may function as a transcriptional repressor. Indicus|evm.model.CM009491.1.544 Q4R506 RL7_MACFA 76.000 0.981707 0.663968 RPL7 - 60S ribosomal protein L7 - Macaca fascicularis (Crab-eating macaque) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Indicus|evm.model.CM009491.1.545 Q9NPA1 KCMB3_HUMAN 77.542 0.741325 1.1362 KCNMB3 - Calcium-activated potassium channel subunit beta-3 - Homo sapiens (Human) - KCNMB3 gene Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. Indicus|evm.model.CM009491.1.546 P32871 PK3CA_BOVIN 100.000 0.998129 1.00094 PIK3CA - Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform - Bos taurus (Bovine) - PIK3CA gene Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:1322797, PubMed:14729945). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway (By similarity). In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed:15178440, PubMed:14729945). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity). Indicus|evm.model.CM009491.1.547 Q0IIC4 ZMAT3_BOVIN 100.000 0.993103 1.00346 ZMAT3 - Zinc finger matrin-type protein 3 - Bos taurus (Bovine) - ZMAT3 gene Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus (By similarity). Indicus|evm.model.CM009491.1.548 Q9Y691 KCMB2_HUMAN 99.574 0.906977 1.09787 KCNMB2 - Calcium-activated potassium channel subunit beta-2 - Homo sapiens (Human) - KCNMB2 gene Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Indicus|evm.model.CM009491.1.549 F1N5S9 FUND1_BOVIN 100.000 0.982759 0.748387 FUNDC1 - FUN14 domain-containing protein 1 - Bos taurus (Bovine) - FUNDC1 gene Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Indicus|evm.model.CM009491.1.551 Q9BZK7 TBL1R_HUMAN 99.416 0.996117 1.00195 TBL1XR1 - F-box-like/WD repeat-containing protein TBL1XR1 - Homo sapiens (Human) - TBL1XR1 gene F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Indicus|evm.model.CM009491.1.554 Q58DX5 NADL2_HUMAN 82.716 0.987654 0.101887 NAALADL2 - Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 - Homo sapiens (Human) - NAALADL2 gene May be catalytically inactive. Indicus|evm.model.CM009491.1.555 Q58DX5 NADL2_HUMAN 84.058 0.985612 0.174843 NAALADL2 - Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 - Homo sapiens (Human) - NAALADL2 gene May be catalytically inactive. Indicus|evm.model.CM009491.1.557 Q58DX5 NADL2_HUMAN 86.228 0.988095 0.211321 NAALADL2 - Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 - Homo sapiens (Human) - NAALADL2 gene May be catalytically inactive. Indicus|evm.model.CM009491.1.558 Q28554 G3P_SHEEP 98.400 0.976378 0.39441 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Ovis aries (Sheep) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Indicus|evm.model.CM009491.1.559 Q8N2Q7 NLGN1_HUMAN 99.836 0.982201 0.716107 NLGN1 - Neuroligin-1 precursor - Homo sapiens (Human) - NLGN1 gene Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development. Indicus|evm.model.CM009491.1.560 Q63HK3 ZKSC2_HUMAN 76.438 0.7 0.537746 ZKSCAN2 - Zinc finger protein with KRAB and SCAN domains 2 - Homo sapiens (Human) - ZKSCAN2 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009491.1.561 P62936 PPIA_PIG 94.000 0.846154 0.713415 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009491.1.563 Q5R893 H2B1_PONAB 90.476 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009491.1.564 Q4R3V2 SPT16_MACFA 88.889 0.996303 0.950791 SPATA16 - Spermatogenesis-associated protein 16 - Macaca fascicularis (Crab-eating macaque) - SPATA16 gene Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. Indicus|evm.model.CM009491.1.565 Q9H8V3 ECT2_HUMAN 93.982 0.997814 1.00109 ECT2 - Protein ECT2 - Homo sapiens (Human) - ECT2 gene Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. Indicus|evm.model.CM009491.1.566 Q1JQE6 NCEH1_BOVIN 99.265 0.99511 1.00245 NCEH1 - Neutral cholesterol ester hydrolase 1 - Bos taurus (Bovine) - NCEH1 gene Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). May be responsible for cholesterol ester hydrolysis in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). Indicus|evm.model.CM009491.1.567 P50591 TNF10_HUMAN 68.858 0.993056 1.02491 TNFSF10 - Tumor necrosis factor ligand superfamily member 10 - Homo sapiens (Human) - TNFSF10 gene Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Indicus|evm.model.CM009491.1.568 A5A4L1 GHSR_MUSPF 96.995 0.99455 1.00273 GHSR - Growth hormone secretagogue receptor type 1 - Mustela putorius furo (European domestic ferret) - GHSR gene Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) (By similarity). Indicus|evm.model.CM009491.1.569 Q53EP0 FND3B_HUMAN 96.520 0.998344 1.00332 FNDC3B - Fibronectin type III domain-containing protein 3B - Homo sapiens (Human) - FNDC3B gene May be a positive regulator of adipogenesis. Indicus|evm.model.CM009491.1.570 A5D787 M17L2_BOVIN 98.165 0.990868 1.00459 MPV17L2 - Mpv17-like protein 2 - Bos taurus (Bovine) - MPV17L2 gene Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity). Indicus|evm.model.CM009491.1.571 A6NML5 TM212_HUMAN 80.110 0.952381 0.974227 TMEM212 - Transmembrane protein 212 - Homo sapiens (Human) - TMEM212 gene Indicus|evm.model.CM009491.1.572 Q13393 PLD1_HUMAN 91.814 0.99814 1.00093 PLD1 - Phospholipase D1 - Homo sapiens (Human) - PLD1 gene Function as phospholipase selective for phosphatidylcholine (PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). Indicus|evm.model.CM009491.1.573 P58351 GTR2_BOVIN 100.000 0.250678 3.61373 SLC2A2 - Solute carrier family 2, facilitated glucose transporter member 2 - Bos taurus (Bovine) - SLC2A2 gene Facilitative hexose transporter that mediates the transport of glucose and fructose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate. Indicus|evm.model.CM009491.1.574 Q5R898 IF5A2_PONAB 100.000 0.787565 1.26144 EIF5A2 - Eukaryotic translation initiation factor 5A-2 - Pongo abelii (Sumatran orangutan) - EIF5A2 gene mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). Indicus|evm.model.CM009491.1.575 A4FUH0 RL22L_BOVIN 99.180 0.98374 1.0082 RPL22L1 - 60S ribosomal protein L22-like 1 - Bos taurus (Bovine) - RPL22L1 gene RNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009491.1.576 A0JNI9 S7A14_BOVIN 100.000 0.851371 0.898833 SLC7A14 - Probable cationic amino acid transporter - Bos taurus (Bovine) - SLC7A14 gene plasma membrane, amino acid transmembrane transporter activity, amino acid transport Indicus|evm.model.CM009491.1.577 Q3MHK4 CLD11_BOVIN 99.517 0.985646 1.00966 CLDN11 - Claudin-11 - Bos taurus (Bovine) - CLDN11 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009491.1.578 Q5R431 SKIL_PONAB 90.949 0.99708 1.00146 SKIL - Ski-like protein - Pongo abelii (Sumatran orangutan) - SKIL gene May have regulatory role in cell division or differentiation in response to extracellular signals. Indicus|evm.model.CM009491.1.579 Q5R4K9 KPCI_PONAB 99.497 0.99665 1.00168 PRKCI - Protein kinase C iota type - Pongo abelii (Sumatran orangutan) - PRKCI gene Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis (By similarity). Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). Indicus|evm.model.CM009491.1.580 Q8NDX5 PHC3_HUMAN 96.646 0.985958 1.01424 PHC3 - Polyhomeotic-like protein 3 - Homo sapiens (Human) - PHC3 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Indicus|evm.model.CM009491.1.581 Q3T171 RL36_BOVIN 94.681 0.877358 1.00952 RPL36 - 60S ribosomal protein L36 - Bos taurus (Bovine) - RPL36 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009491.1.582 Q99442 SEC62_HUMAN 97.995 0.995 1.00251 SEC62 - Translocation protein SEC62 - Homo sapiens (Human) - SEC62 gene Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Indicus|evm.model.CM009491.1.583 Q7Z3H4 SAMD7_HUMAN 71.264 0.942935 0.825112 SAMD7 - Sterile alpha motif domain-containing protein 7 - Homo sapiens (Human) - SAMD7 gene Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes. Indicus|evm.model.CM009491.1.584 Q6UY01 LRC31_HUMAN 72.710 0.952849 0.922101 LRRC31 - Leucine-rich repeat-containing protein 31 - Homo sapiens (Human) - LRRC31 gene Indicus|evm.model.CM009491.1.585 A6NIV6 LRIQ4_HUMAN 60.794 0.854664 0.823214 LRRIQ4 - Leucine-rich repeat and IQ domain-containing protein 4 - Homo sapiens (Human) - LRRIQ4 gene cytoplasm, intracellular membrane-bounded organelle, protein serine/threonine phosphatase activity, signal transduction Indicus|evm.model.CM009491.1.586 Q8IZ02 LRC34_HUMAN 80.876 0.955752 0.974138 LRRC34 - Leucine-rich repeat-containing protein 34 - Homo sapiens (Human) - LRRC34 gene Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. Indicus|evm.model.CM009491.1.587 Q9NPC7 MYNN_HUMAN 92.561 0.879205 1.07213 MYNN - Myoneurin - Homo sapiens (Human) - MYNN gene nucleoplasm, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009491.1.588 Q9BYD9 ACTT3_HUMAN 80.645 0.834091 1.1828 ACTRT3 - Actin-related protein T3 - Homo sapiens (Human) - ACTRT3 gene Indicus|evm.model.CM009491.1.590 O75095 MEGF6_HUMAN 51.799 0.975265 0.183647 MEGF6 - Multiple epidermal growth factor-like domains protein 6 precursor - Homo sapiens (Human) - MEGF6 gene Indicus|evm.model.CM009491.1.591 Q0D2K5 EGFEM_HUMAN 54.194 0.280734 2.79487 EGFEM1P - Putative EGF-like and EMI domain-containing protein 1 - Homo sapiens (Human) - EGFEM1P gene Indicus|evm.model.CM009491.1.592 Q8C088 EGFEM_MOUSE 62.069 0.727848 0.267797 Egfem1 - EGF-like and EMI domain-containing protein 1 precursor - Mus musculus (Mouse) - Egfem1 gene Indicus|evm.model.CM009491.1.594 O00461 GOLI4_HUMAN 81.779 0.997006 0.95977 GOLIM4 - Golgi integral membrane protein 4 - Homo sapiens (Human) - GOLIM4 gene Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. Indicus|evm.model.CM009491.1.597 Q99574 NEUS_HUMAN 91.463 0.995134 1.00244 SERPINI1 - Neuroserpin precursor - Homo sapiens (Human) - SERPINI1 gene Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable). Indicus|evm.model.CM009491.1.598 Q8VE70 PDC10_MOUSE 100.000 0.99061 1.00472 Pdcd10 - Programmed cell death protein 10 - Mus musculus (Mouse) - Pdcd10 gene Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Indicus|evm.model.CM009491.1.599 Q8IV35 WDR49_HUMAN 80.909 0.640594 1.44907 WDR49 - WD repeat-containing protein 49 - Homo sapiens (Human) - WDR49 gene Indicus|evm.model.CM009491.1.600 O75830 SPI2_HUMAN 84.938 0.995074 1.00247 SERPINI2 - Serpin I2 precursor - Homo sapiens (Human) - SERPINI2 gene extracellular exosome, extracellular space, serine-type endopeptidase inhibitor activity, negative regulation of endopeptidase activity Indicus|evm.model.CM009491.1.601 A8MT70 ZBBX_HUMAN 75.472 0.981308 0.13375 ZBBX - Zinc finger B-box domain-containing protein 1 - Homo sapiens (Human) - ZBBX gene motile cilium, cilium movement Indicus|evm.model.CM009491.1.602 A8MT70 ZBBX_HUMAN 68.103 0.980226 0.885 ZBBX - Zinc finger B-box domain-containing protein 1 - Homo sapiens (Human) - ZBBX gene motile cilium, cilium movement Indicus|evm.model.CM009491.1.604 P61246 RS3A_FELCA 48.163 0.862745 0.784615 RPS3A - 40S ribosomal protein S3a - Felis catus (Cat) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009491.1.607 O94933 SLIK3_HUMAN 97.446 0.996942 1.00409 SLITRK3 - SLIT and NTRK-like protein 3 precursor - Homo sapiens (Human) - SLITRK3 gene Suppresses neurite outgrowth. Indicus|evm.model.CM009491.1.608 P14410 SUIS_HUMAN 81.117 0.982447 0.997811 SI - Sucrase-isomaltase, intestinal - Homo sapiens (Human) - SI gene Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides. Indicus|evm.model.CM009491.1.609 P02584 PROF1_BOVIN 99.286 0.985816 1.00714 PFN1 - Profilin-1 - Bos taurus (Bovine) - PFN1 gene Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). Indicus|evm.model.CM009491.1.610 P62907 RL10A_RAT 98.157 0.990826 1.00461 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Indicus|evm.model.CM009491.1.611 Q6AYU1 MO4L1_RAT 76.344 0.625 0.44582 Morf4l1 - Mortality factor 4-like protein 1 - Rattus norvegicus (Rat) - Morf4l1 gene Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci (By similarity). Indicus|evm.model.CM009491.1.612 Q9Y448 SKAP_HUMAN 84.706 0.965116 0.544304 KNSTRN - Small kinetochore-associated protein - Homo sapiens (Human) - KNSTRN gene Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). Indicus|evm.model.CM009491.1.614 A6NHN0 OTOL1_HUMAN 78.333 0.995781 0.993711 OTOL1 - Otolin-1 precursor - Homo sapiens (Human) - OTOL1 gene Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics. Indicus|evm.model.CM009491.1.615 Q5R893 H2B1_PONAB 93.651 0.968992 1.02381 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009491.1.616 Q2KJ61 ELP3_BOVIN 88.320 0.962422 0.875686 ELP3 - Elongator complex protein 3 - Bos taurus (Bovine) - ELP3 gene Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). Indicus|evm.model.CM009491.1.617 Q08DS5 NMD3_BOVIN 100.000 0.996032 1.00199 NMD3 - 60S ribosomal export protein NMD3 - Bos taurus (Bovine) - NMD3 gene Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. Indicus|evm.model.CM009491.1.618 Q864U6 B3GL1_PIG 96.979 0.993976 1.00302 B3GALNT1 - UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 - Sus scrofa (Pig) - B3GALNT1 gene Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development. Indicus|evm.model.CM009491.1.619 A5PJZ2 PPM1L_BOVIN 99.722 0.99446 1.00278 PPM1L - Protein phosphatase 1L - Bos taurus (Bovine) - PPM1L gene Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Indicus|evm.model.CM009491.1.620 Q5R1W0 ANXA5_PANTR 92.857 0.466102 0.36875 ANXA5 - Annexin A5 - Pan troglodytes (Chimpanzee) - ANXA5 gene This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Indicus|evm.model.CM009491.1.621 P81287 ANXA5_BOVIN 96.859 0.989583 0.598131 ANXA5 - Annexin A5 - Bos taurus (Bovine) - ANXA5 gene This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Indicus|evm.model.CM009491.1.622 Q8N4G2 ARL14_HUMAN 83.333 0.989637 1.00521 ARL14 - ADP-ribosylation factor-like protein 14 - Homo sapiens (Human) - ARL14 gene GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. Indicus|evm.model.CM009491.1.623 O00629 IMA3_HUMAN 99.808 0.996169 1.00192 KPNA4 - Importin subunit alpha-3 - Homo sapiens (Human) - KPNA4 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Indicus|evm.model.CM009491.1.625 Q8IWR1 TRI59_HUMAN 87.841 0.995037 1 TRIM59 - Tripartite motif-containing protein 59 - Homo sapiens (Human) - TRIM59 gene May serve as a multifunctional regulator for innate immune signaling pathways. Indicus|evm.model.CM009491.1.626 Q9NTJ3 SMC4_HUMAN 93.328 0.998448 1.00078 SMC4 - Structural maintenance of chromosomes protein 4 - Homo sapiens (Human) - SMC4 gene Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Indicus|evm.model.CM009491.1.627 Q9P2H3 IFT80_HUMAN 90.625 0.150831 1.08366 IFT80 - Intraflagellar transport protein 80 homolog - Homo sapiens (Human) - IFT80 gene Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. Indicus|evm.model.CM009491.1.628 F5H4A9 CC080_HUMAN 86.345 0.991903 1 C3orf80 - Uncharacterized membrane protein C3orf80 precursor - Homo sapiens (Human) - C3orf80 gene Indicus|evm.model.CM009491.1.630 P54349 IL12A_BOVIN 100.000 0.990991 1.00452 IL12A - Interleukin-12 subunit alpha precursor - Bos taurus (Bovine) - IL12A gene Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Indicus|evm.model.CM009491.1.631 B3KU38 IQIP1_HUMAN 93.576 0.86729 0.950266 IQCJ-SCHIP1 - IQCJ-SCHIP1 readthrough transcript protein - Homo sapiens (Human) - IQCJ-SCHIP1 gene May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943). May also play a role in axon outgrowth and guidance (By similarity). Indicus|evm.model.CM009491.1.632 P00011 CYC_CANLF 75.238 0.980952 1 CYCS - Cytochrome c - Canis lupus familiaris (Dog) - CYCS gene Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Indicus|evm.model.CM009491.1.633 Q1A5X6 IQCJ_HUMAN 88.235 0.807229 0.522013 IQCJ - IQ domain-containing protein J - Homo sapiens (Human) - IQCJ gene Indicus|evm.model.CM009491.1.634 P41231 P2RY2_HUMAN 46.053 0.822404 0.970822 P2RY2 - P2Y purinoceptor 2 - Homo sapiens (Human) - P2RY2 gene Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. Indicus|evm.model.CM009491.1.635 Q1JQC1 MFSD1_BOVIN 99.786 0.995736 1.00214 MFSD1 - Major facilitator superfamily domain-containing protein 1 - Bos taurus (Bovine) - MFSD1 gene Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP. Indicus|evm.model.CM009491.1.636 P49788 TIG1_HUMAN 64.966 0.992565 0.914966 RARRES1 - Retinoic acid receptor responder protein 1 - Homo sapiens (Human) - RARRES1 gene Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle. Indicus|evm.model.CM009491.1.637 Q8K0D5 EFGM_MOUSE 93.360 0.997347 1.00399 Gfm1 - Elongation factor G, mitochondrial precursor - Mus musculus (Mouse) - Gfm1 gene Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Indicus|evm.model.CM009491.1.638 Q32KY3 MLF1_BOVIN 95.070 0.992982 1.05556 MLF1 - Myeloid leukemia factor 1 - Bos taurus (Bovine) - MLF1 gene Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus (By similarity). Indicus|evm.model.CM009491.1.639 Q2T9Y0 RSRC1_BOVIN 100.000 0.99403 1.00299 RSRC1 - Serine/Arginine-related protein 53 - Bos taurus (Bovine) - RSRC1 gene Plays a role in pre-mRNA splicing. Involved both in the constitutive and regulation of pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing (By similarity). Indicus|evm.model.CM009491.1.641 O35750 SHOX2_RAT 97.890 0.710843 1.40084 Shox2 - Short stature homeobox protein 2 - Rattus norvegicus (Rat) - Shox2 gene May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. Indicus|evm.model.CM009491.1.644 Q14D04 MELT_HUMAN 90.089 0.997462 0.945978 VEPH1 - Ventricular zone-expressed PH domain-containing protein homolog 1 - Homo sapiens (Human) - VEPH1 gene Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. Indicus|evm.model.CM009491.1.645 Q52KE7 CCNL1_MOUSE 100.000 0.705202 0.325188 Ccnl1 - Cyclin-L1 - Mus musculus (Mouse) - Ccnl1 gene Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). May play a role in the regulation of RNA polymerase II (pol II). Inhibited by the CDK-specific inhibitor CDKN1A/p21. Indicus|evm.model.CM009491.1.646 Q9UK58 CCNL1_HUMAN 98.082 0.978495 0.707224 CCNL1 - Cyclin-L1 - Homo sapiens (Human) - CCNL1 gene Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). Indicus|evm.model.CM009491.1.647 Q6ZMV7 LEKR1_HUMAN 81.186 0.643927 1.54897 LEKR1 - Leucine-, glutamate- and lysine-rich protein 1 - Homo sapiens (Human) - LEKR1 gene Indicus|evm.model.CM009491.1.650 Q7Z3E1 PARPT_HUMAN 94.825 0.996956 1 TIPARP - Protein mono-ADP-ribosyltransferase TIPARP - Homo sapiens (Human) - TIPARP gene ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764). Indicus|evm.model.CM009491.1.651 Q3SZ87 SSRG_BOVIN 100.000 0.989247 1.00541 SSR3 - Translocon-associated protein subunit gamma - Bos taurus (Bovine) - SSR3 gene TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Indicus|evm.model.CM009491.1.652 P63144 KCAB1_RAT 100.000 0.850746 1.00249 Kcnab1 - Voltage-gated potassium channel subunit beta-1 - Rattus norvegicus (Rat) - Kcnab1 gene Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits (Probable). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:8183366, PubMed:15618540, PubMed:18222921). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:10064591, PubMed:10650996, PubMed:16504945). Accelerates KCNA4 channel closure (PubMed:8183366). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:16504945). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (PubMed:15618540). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity. Has NADPH-dependent aldoketoreductase activity (PubMed:18222921). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (PubMed:18222921, PubMed:21436029). Indicus|evm.model.CM009491.1.653 Q4R7Y2 RL10_MACFA 70.000 0.583333 0.392523 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009491.1.654 Q14722 KCAB1_HUMAN 81.522 0.947917 0.229117 KCNAB1 - Voltage-gated potassium channel subunit beta-1 - Homo sapiens (Human) - KCNAB1 gene Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). Indicus|evm.model.CM009491.1.655 O70410 V2R1_MOUSE 74.074 0.38843 0.530702 Vmn2r1 - Vomeronasal type-2 receptor 1 precursor - Mus musculus (Mouse) - Vmn2r1 gene Putative pheromone receptor. Indicus|evm.model.CM009491.1.656 P49915 GUAA_HUMAN 98.830 0.988423 0.997114 GMPS - GMP synthase [glutamine-hydrolyzing] - Homo sapiens (Human) - GMPS gene Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. Indicus|evm.model.CM009491.1.657 Q5E951 TBCB_BOVIN 91.824 0.934911 0.692623 TBCB - Tubulin-folding cofactor B - Bos taurus (Bovine) - TBCB gene Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. Indicus|evm.model.CM009491.1.658 O00400 ACATN_HUMAN 92.364 0.99637 1.00364 SLC33A1 - Acetyl-coenzyme A transporter 1 - Homo sapiens (Human) - SLC33A1 gene Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:9096318). Negatively regulates BMP signaling (PubMed:25402622). Indicus|evm.model.CM009491.1.659 Q6P1S2 CC033_HUMAN 68.259 0.987854 0.840136 C3orf33 - Protein C3orf33 - Homo sapiens (Human) - C3orf33 gene Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane. Indicus|evm.model.CM009491.1.661 Q4KWH8 PLCH1_HUMAN 87.120 0.998787 0.974011 PLCH1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 - Homo sapiens (Human) - PLCH1 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. Indicus|evm.model.CM009491.1.662 P07861 NEP_RAT 91.333 0.997337 1.00133 Mme - Neprilysin - Rattus norvegicus (Rat) - Mme gene Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:2966343) (By similarity). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:2966343) (By similarity). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:2966343) (By similarity). Involved in the degradation of the atrial natriuretic factor (ANF) (PubMed:2966343). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity). Indicus|evm.model.CM009491.1.663 P57054 PIGP_HUMAN 92.188 0.984496 0.816456 PIGP - Phosphatidylinositol N-acetylglucosaminyltransferase subunit P - Homo sapiens (Human) - PIGP gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Indicus|evm.model.CM009491.1.664 Q86SP6 GP149_HUMAN 83.512 0.995984 1.02189 GPR149 - Probable G-protein coupled receptor 149 - Homo sapiens (Human) - GPR149 gene Orphan receptor. Indicus|evm.model.CM009491.1.665 Q05B79 DHX36_BOVIN 99.703 0.998022 1.00099 DHX36 - ATP-dependent DNA/RNA helicase DHX36 - Bos taurus (Bovine) - DHX36 gene Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:29899445). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (By similarity). G4 structures correspond to helical structures containing guanine tetrads (PubMed:29899445). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (PubMed:29899445) (By similarity). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (By similarity). Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (By similarity). Plays a role in post-transcriptional regulation. Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (By similarity). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (By similarity). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (By similarity). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (By similarity). Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (By similarity). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for the early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). Indicus|evm.model.CM009491.1.666 Q96DR7 ARHGQ_HUMAN 97.321 0.995546 0.515499 ARHGEF26 - Rho guanine nucleotide exchange factor 26 - Homo sapiens (Human) - ARHGEF26 gene Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. Indicus|evm.model.CM009491.1.669 Q8NI27 THOC2_HUMAN 97.053 0.333771 0.95543 THOC2 - THO complex subunit 2 - Homo sapiens (Human) - THOC2 gene Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. Indicus|evm.model.CM009491.1.671 P61227 RAP2B_RAT 99.454 0.98913 1.00546 Rap2b - Ras-related protein Rap-2b precursor - Rattus norvegicus (Rat) - Rap2b gene Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells (By similarity). Indicus|evm.model.CM009491.1.672 P48042 P2RY1_BOVIN 100.000 0.994652 1.00268 P2RY1 - P2Y purinoceptor 1 - Bos taurus (Bovine) - P2RY1 gene Receptor for extracellular adenine nucleotides such as ADP (PubMed:7626079). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity). Indicus|evm.model.CM009491.1.674 Q920A7 AFG31_MOUSE 74.359 0.8 0.183777 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Indicus|evm.model.CM009491.1.675 Q2TBY0 SKA2_BOVIN 93.388 0.983607 1.00826 SKA2 - Spindle and kinetochore-associated protein 2 - Bos taurus (Bovine) - SKA2 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Indicus|evm.model.CM009491.1.676 Q9JKP5 MBNL1_MOUSE 99.698 0.863874 1.12023 Mbnl1 - Muscleblind-like protein 1 - Mus musculus (Mouse) - Mbnl1 gene Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs (By similarity). Indicus|evm.model.CM009491.1.677 Q9BXA5 SUCR1_HUMAN 78.931 0.993691 0.949102 SUCNR1 - Succinate receptor 1 - Homo sapiens (Human) - SUCNR1 gene Receptor for succinate. Indicus|evm.model.CM009491.1.678 Q0P5B7 AAAD_BOVIN 99.717 0.99435 0.887218 AADAC - Arylacetamide deacetylase - Bos taurus (Bovine) - AADAC gene Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity (By similarity). Indicus|evm.model.CM009491.1.680 Q3SX46 C1GLC_BOVIN 86.164 0.99373 1.00314 C1GALT1C1 - C1GALT1-specific chaperone 1 - Bos taurus (Bovine) - C1GALT1C1 gene Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity). Indicus|evm.model.CM009491.1.681 Q6WRI0 IGS10_HUMAN 73.620 0.999151 0.897827 IGSF10 - Immunoglobulin superfamily member 10 precursor - Homo sapiens (Human) - IGSF10 gene Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity). Indicus|evm.model.CM009491.1.682 Q86YW9 MD12L_HUMAN 97.159 0.999069 1.0014 MED12L - Mediator of RNA polymerase II transcription subunit 12-like protein - Homo sapiens (Human) - MED12L gene May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009491.1.684 A8MYZ0 MIY4B_HUMAN 80.511 0.968944 0.7 MINDY4B - Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B - Homo sapiens (Human) - MINDY4B gene Lys48-specific deubiquitinase activity Indicus|evm.model.CM009491.1.686 O43255 SIAH2_HUMAN 99.459 0.605263 0.938272 SIAH2 - E3 ubiquitin-protein ligase SIAH2 - Homo sapiens (Human) - SIAH2 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:9334332, PubMed:11483518, PubMed:19224863). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:9334332, PubMed:11483518, PubMed:19224863). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:9334332, PubMed:11483518, PubMed:19224863). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:9334332, PubMed:11483518, PubMed:19224863). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (PubMed:22878263). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:9334332, PubMed:11483518, PubMed:19224863, PubMed:22878263). Has some overlapping function with SIAH1 (PubMed:9334332, PubMed:11483518, PubMed:19224863). Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (PubMed:12411493). Promotes monoubiquitination of SNCA (PubMed:19224863). Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (PubMed:26392558). Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Indicus|evm.model.CM009491.1.687 Q7L0X2 ERIP6_HUMAN 75.290 0.894188 1.01207 ERICH6 - Glutamate-rich protein 6 - Homo sapiens (Human) - ERICH6 gene Indicus|evm.model.CM009491.1.688 A6QP01 SELT_BOVIN 95.455 0.650442 1.15897 SELENOT - Thioredoxin reductase-like selenoprotein T precursor - Bos taurus (Bovine) - SELENOT gene Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (By similarity). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity). Indicus|evm.model.CM009491.1.689 Q9BY44 EIF2A_HUMAN 93.892 0.954925 1.02393 EIF2A - Eukaryotic translation initiation factor 2A - Homo sapiens (Human) - EIF2A gene Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. Indicus|evm.model.CM009491.1.690 O75157 T22D2_HUMAN 84.802 0.997423 0.994872 TSC22D2 - TSC22 domain family protein 2 - Homo sapiens (Human) - TSC22D2 gene Indicus|evm.model.CM009491.1.691 Q9EPC6 PROF2_RAT 100.000 0.964286 0.4 Pfn2 - Profilin-2 - Rattus norvegicus (Rat) - Pfn2 gene Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). Indicus|evm.model.CM009491.1.692 Q0VD51 RNF13_BOVIN 100.000 0.994751 1.00263 RNF13 - E3 ubiquitin-protein ligase RNF13 precursor - Bos taurus (Bovine) - RNF13 gene E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. Indicus|evm.model.CM009491.1.693 A6NFN9 ANKUB_HUMAN 82.470 0.917431 1.08566 ANKUB1 - Protein ANKUB1 - Homo sapiens (Human) - ANKUB1 gene Indicus|evm.model.CM009491.1.694 Q86X83 COMD2_HUMAN 91.720 0.96875 0.80402 COMMD2 - COMM domain-containing protein 2 - Homo sapiens (Human) - COMMD2 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Indicus|evm.model.CM009491.1.695 Q9GZV5 WWTR1_HUMAN 97.500 0.77176 1.2925 WWTR1 - WW domain-containing transcription regulator protein 1 - Homo sapiens (Human) - WWTR1 gene Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). Indicus|evm.model.CM009491.1.696 Q91XD3 T4S4_MOUSE 84.492 0.911765 1.0099 Tm4sf4 - Transmembrane 4 L6 family member 4 - Mus musculus (Mouse) - Tm4sf4 gene Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation (By similarity). Indicus|evm.model.CM009491.1.697 Q5RE43 T4S1_PONAB 85.644 0.681356 1.4604 TM4SF1 - Transmembrane 4 L6 family member 1 - Pongo abelii (Sumatran orangutan) - TM4SF1 gene Indicus|evm.model.CM009491.1.698 Q3T110 T4S18_BOVIN 100.000 0.990099 1.00498 TM4SF18 - Transmembrane 4 L6 family member 18 - Bos taurus (Bovine) - TM4SF18 gene integral component of membrane Indicus|evm.model.CM009491.1.699 P13635 CERU_RAT 56.712 0.969231 0.92068 Cp - Ceruloplasmin precursor - Rattus norvegicus (Rat) - Cp gene Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. May also play a role in fetal lung development or pulmonary antioxidant defense. involved in iron transport across the cell membrane (By similarity). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Indicus|evm.model.CM009491.1.700 Q9XT27 CERU_SHEEP 95.853 0.998115 1.0124 CP - Ceruloplasmin precursor - Ovis aries (Sheep) - CP gene Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (By similarity). Indicus|evm.model.CM009491.1.701 Q969F9 HPS3_HUMAN 89.641 0.998008 1 HPS3 - Hermansky-Pudlak syndrome 3 protein - Homo sapiens (Human) - HPS3 gene Involved in early stages of melanosome biogenesis and maturation. Indicus|evm.model.CM009491.1.702 Q14527 HLTF_HUMAN 91.386 0.99802 1.00099 HLTF - Helicase-like transcription factor - Homo sapiens (Human) - HLTF gene Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. Indicus|evm.model.CM009491.1.703 P13280 GLYG_RABIT 89.728 0.9375 1.05706 GYG1 - Glycogenin-1 - Oryctolagus cuniculus (Rabbit) - GYG1 gene Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. Indicus|evm.model.CM009491.1.704 P15088 CBPA3_HUMAN 84.892 0.995215 1.0024 CPA3 - Mast cell carboxypeptidase A precursor - Homo sapiens (Human) - CPA3 gene collagen-containing extracellular matrix, extracellular region, extracellular space, secretory granule, metallocarboxypeptidase activity, angiotensin maturation, proteolysis Indicus|evm.model.CM009491.1.705 P00732 CBPB1_BOVIN 99.760 0.995215 1.0024 CPB1 - Carboxypeptidase B precursor - Bos taurus (Bovine) - CPB1 gene extracellular space, metallocarboxypeptidase activity, proteolysis Indicus|evm.model.CM009491.1.706 P25104 AGTR1_BOVIN 99.721 0.994444 1.00279 AGTR1 - Type-1 angiotensin II receptor - Bos taurus (Bovine) - AGTR1 gene Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009491.1.708 Q9D287 SPF27_MOUSE 99.310 0.90566 0.706667 Bcas2 - Pre-mRNA-splicing factor SPF27 - Mus musculus (Mouse) - Bcas2 gene Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). Indicus|evm.model.CM009491.1.709 Q2YDK4 HMGN4_BOVIN 94.444 0.978022 1.01111 HMGN4 - High mobility group nucleosome-binding domain-containing protein 4 - Bos taurus (Bovine) - HMGN4 gene nucleus, chromatin binding, chromatin organization Indicus|evm.model.CM009491.1.710 Q7TSH9 ZN184_MOUSE 55.780 0.567434 0.824966 Zfp184 - Zinc finger protein 184 - Mus musculus (Mouse) - Zfp184 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009491.1.711 P62752 RL23A_RAT 66.667 0.555556 0.403846 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009491.1.713 Q8N9L1 ZIC4_HUMAN 93.134 0.860825 1.16168 ZIC4 - Zinc finger protein ZIC 4 - Homo sapiens (Human) - ZIC4 gene Binds to DNA. Indicus|evm.model.CM009491.1.714 A0PG75 PLS5_HUMAN 94.505 0.937824 0.712177 PLSCR5 - Phospholipid scramblase family member 5 - Homo sapiens (Human) - PLSCR5 gene plasma membrane, phospholipid scramblase activity, plasma membrane phospholipid scrambling Indicus|evm.model.CM009491.1.715 Q3ZBG9 PLS2_BOVIN 100.000 0.993197 1.00341 PLSCR2 - Phospholipid scramblase 2 - Bos taurus (Bovine) - PLSCR2 gene May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system (By similarity). Indicus|evm.model.CM009491.1.716 Q9JJ00 PLS1_MOUSE 55.981 0.877637 0.722561 Plscr1 - Phospholipid scramblase 1 - Mus musculus (Mouse) - Plscr1 gene Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific distribution of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:32110987). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (PubMed:32110987). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (By similarity). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (PubMed:12010804). Indicus|evm.model.CM009491.1.717 Q9NRQ2 PLS4_HUMAN 81.402 0.979042 1.0152 PLSCR4 - Phospholipid scramblase 4 - Homo sapiens (Human) - PLSCR4 gene May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Indicus|evm.model.CM009491.1.718 O00469 PLOD2_HUMAN 91.601 0.997379 1.03528 PLOD2 - Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 precursor - Homo sapiens (Human) - PLOD2 gene Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. Indicus|evm.model.CM009491.1.719 P09104 ENOG_HUMAN 70.769 0.955224 0.154378 ENO2 - Gamma-enolase - Homo sapiens (Human) - ENO2 gene Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). Indicus|evm.model.CM009491.1.720 Q8NDZ4 DIK2A_HUMAN 99.767 0.99536 1.00233 DIPK2A - Divergent protein kinase domain 2A precursor - Homo sapiens (Human) - DIPK2A gene May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade. Indicus|evm.model.CM009491.1.721 Q8IVB4 SL9A9_HUMAN 94.954 0.93133 0.36124 SLC9A9 - Sodium/hydrogen exchanger 9 - Homo sapiens (Human) - SLC9A9 gene May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell. Indicus|evm.model.CM009491.1.722 Q8IVB4 SL9A9_HUMAN 92.308 0.666667 0.390698 SLC9A9 - Sodium/hydrogen exchanger 9 - Homo sapiens (Human) - SLC9A9 gene May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell. Indicus|evm.model.CM009491.1.723 Q8IVB4 SL9A9_HUMAN 83.929 0.786765 0.210853 SLC9A9 - Sodium/hydrogen exchanger 9 - Homo sapiens (Human) - SLC9A9 gene May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell. Indicus|evm.model.CM009491.1.724 Q9Y4C5 CHST2_HUMAN 95.445 0.995842 0.907547 CHST2 - Carbohydrate sulfotransferase 2 - Homo sapiens (Human) - CHST2 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. Indicus|evm.model.CM009491.1.725 O15042 SR140_HUMAN 99.514 0.998058 1.00097 U2SURP - U2 snRNP-associated SURP motif-containing protein - Homo sapiens (Human) - U2SURP gene nucleoplasm, nucleus, RNA binding, mRNA splicing, via spliceosome Indicus|evm.model.CM009491.1.726 Q6ZVX9 PAQR9_HUMAN 92.838 0.87239 1.14324 PAQR9 - Membrane progestin receptor epsilon - Homo sapiens (Human) - PAQR9 gene Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870). Indicus|evm.model.CM009491.1.727 O46415 FRIL_BOVIN 94.771 0.987013 0.88 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009491.1.728 Q9UKZ9 PCOC2_HUMAN 92.788 0.995204 1.00482 PCOLCE2 - Procollagen C-endopeptidase enhancer 2 precursor - Homo sapiens (Human) - PCOLCE2 gene Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1. Indicus|evm.model.CM009491.1.729 P48995 TRPC1_HUMAN 99.622 0.997484 1.00252 TRPC1 - Short transient receptor potential channel 1 - Homo sapiens (Human) - TRPC1 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Indicus|evm.model.CM009491.1.730 A6H742 PLSI_BOVIN 99.841 0.99683 1.00159 PLS1 - Plastin-1 - Bos taurus (Bovine) - PLS1 gene Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions. Indicus|evm.model.CM009491.1.731 Q13535 ATR_HUMAN 93.691 0.999244 1.00038 ATR - Serine/threonine-protein kinase ATR - Homo sapiens (Human) - ATR gene Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). Indicus|evm.model.CM009491.1.732 Q8IZH2 XRN1_HUMAN 89.736 0.998851 1.02052 XRN1 - 5'-3' exoribonuclease 1 - Homo sapiens (Human) - XRN1 gene Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). Indicus|evm.model.CM009491.1.733 Q08D86 GLPK5_BOVIN 99.063 0.992974 0.808712 GK5 - Putative glycerol kinase 5 - Bos taurus (Bovine) - GK5 gene mitochondrion, glycerol kinase activity, phosphotransferase activity, alcohol group as acceptor, glycerol metabolic process, glycerol-3-phosphate biosynthetic process, phosphorylation, triglyceride metabolic process Indicus|evm.model.CM009491.1.734 Q14188 TFDP2_HUMAN 97.763 0.986726 1.01345 TFDP2 - Transcription factor Dp-2 - Homo sapiens (Human) - TFDP2 gene Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). Indicus|evm.model.CM009491.1.735 P63324 RS12_RAT 85.124 0.983607 0.924242 Rps12 - 40S ribosomal protein S12 - Rattus norvegicus (Rat) - Rps12 gene cytosolic large ribosomal subunit, cytosolic small ribosomal subunit, structural constituent of ribosome, response to organonitrogen compound Indicus|evm.model.CM009491.1.736 Q3T0C6 AT1B3_BOVIN 100.000 0.992857 1.00358 ATP1B3 - Sodium/potassium-transporting ATPase subunit beta-3 - Bos taurus (Bovine) - ATP1B3 gene This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity). Indicus|evm.model.CM009491.1.737 Q8WMV0 GRK7_BOVIN 100.000 0.41623 0.692029 GRK7 - Rhodopsin kinase GRK7 precursor - Bos taurus (Bovine) - GRK7 gene Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). Indicus|evm.model.CM009491.1.738 Q9WTZ1 RBX2_MOUSE 99.115 0.982456 1.00885 Rnf7 - RING-box protein 2 - Mus musculus (Mouse) - Rnf7 gene Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (By similarity). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents (By similarity). Indicus|evm.model.CM009491.1.740 Q15283 RASA2_HUMAN 94.282 0.992136 0.897647 RASA2 - Ras GTPase-activating protein 2 - Homo sapiens (Human) - RASA2 gene Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4). Indicus|evm.model.CM009491.1.741 Q5E984 TCTP_BOVIN 73.469 0.976471 0.494186 TPT1 - Translationally-controlled tumor protein - Bos taurus (Bovine) - TPT1 gene Involved in calcium binding and microtubule stabilization. Indicus|evm.model.CM009491.1.742 Q8NAP3 ZBT38_HUMAN 88.787 0.99834 1.00837 ZBTB38 - Zinc finger and BTB domain-containing protein 38 - Homo sapiens (Human) - ZBTB38 gene Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). Indicus|evm.model.CM009491.1.743 Q8TE99 PXYP1_HUMAN 87.500 0.827869 0.7625 PXYLP1 - 2-phosphoxylose phosphatase 1 - Homo sapiens (Human) - PXYLP1 gene Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. Indicus|evm.model.CM009491.1.745 Q96A44 SPSB4_HUMAN 97.436 0.992701 1.00366 SPSB4 - SPRY domain-containing SOCS box protein 4 - Homo sapiens (Human) - SPSB4 gene Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558). Indicus|evm.model.CM009491.1.747 Q96CQ1 S2536_HUMAN 97.106 0.99359 1.00322 SLC25A36 - Solute carrier family 25 member 36 - Homo sapiens (Human) - SLC25A36 gene Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. Indicus|evm.model.CM009491.1.748 Q9D2H5 TRI42_MOUSE 88.966 0.997245 1.00415 Trim42 - Tripartite motif-containing protein 42 - Mus musculus (Mouse) - Trim42 gene chromatin, nucleoplasm, ubiquitin-protein transferase activity, positive regulation of transcription, DNA-templated Indicus|evm.model.CM009491.1.749 Q9H4D0 CSTN2_HUMAN 93.010 0.995495 0.929843 CLSTN2 - Calsyntenin-2 precursor - Homo sapiens (Human) - CLSTN2 gene May modulate calcium-mediated postsynaptic signals. Indicus|evm.model.CM009491.1.751 Q99JR6 NMNA3_MOUSE 78.607 0.947867 0.861224 Nmnat3 - Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 - Mus musculus (Mouse) - Nmnat3 gene Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. Indicus|evm.model.CM009491.1.752 Q0V7M0 IMA7_BOVIN 100.000 0.996255 0.996269 KPNA6 - Importin subunit alpha-7 - Bos taurus (Bovine) - KPNA6 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Indicus|evm.model.CM009491.1.753 P40222 TXLNA_HUMAN 89.502 0.996441 1.0293 TXLNA - Alpha-taxilin - Homo sapiens (Human) - TXLNA gene May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. Indicus|evm.model.CM009491.1.754 P50121 RET2_PIG 91.045 0.985185 1.00746 RBP2 - Retinol-binding protein 2 - Sus scrofa (Pig) - RBP2 gene Intracellular transport of retinol. Indicus|evm.model.CM009491.1.755 P35605 COPB2_BOVIN 97.500 0.209677 0.205298 COPB2 - Coatomer subunit beta' - Bos taurus (Bovine) - COPB2 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Indicus|evm.model.CM009491.1.756 P82649 RT22_BOVIN 99.721 0.99169 1.00557 MRPS22 - 28S ribosomal protein S22, mitochondrial - Bos taurus (Bovine) - MRPS22 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009491.1.757 P35605 COPB2_BOVIN 99.711 0.994245 0.767108 COPB2 - Coatomer subunit beta' - Bos taurus (Bovine) - COPB2 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Indicus|evm.model.CM009491.1.758 Q6ZRT6 PR23B_HUMAN 52.273 0.988417 0.977358 PRR23B - Proline-rich protein 23B - Homo sapiens (Human) - PRR23B gene Indicus|evm.model.CM009491.1.760 A6NEV1 PR23A_HUMAN 48.519 0.875839 1.1203 PRR23A - Proline-rich protein 23A - Homo sapiens (Human) - PRR23A gene Indicus|evm.model.CM009491.1.761 Q5RFL9 NONO_PONAB 100.000 0.977528 0.18896 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009491.1.762 Q5FVM4 NONO_RAT 97.797 0.991228 0.478992 Nono - Non-POU domain-containing octamer-binding protein - Rattus norvegicus (Rat) - Nono gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009491.1.763 Q5RFL9 NONO_PONAB 96.610 0.983051 0.250531 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009491.1.764 A6NEV1 PR23A_HUMAN 48.148 0.890785 1.1015 PRR23A - Proline-rich protein 23A - Homo sapiens (Human) - PRR23A gene Indicus|evm.model.CM009491.1.766 Q6ZRT6 PR23B_HUMAN 49.064 0.984733 0.988679 PRR23B - Proline-rich protein 23B - Homo sapiens (Human) - PRR23B gene Indicus|evm.model.CM009491.1.767 Q6VFT7 FOXL2_BOVIN 98.020 0.487864 1.09284 FOXL2 - Forkhead box protein L2 - Bos taurus (Bovine) - FOXL2 gene Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity). Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells (By similarity). Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Activates SIRT1 transcription under cellular stress conditions (By similarity). Activates transcription of OSR2 (By similarity). Is a regulator of CYP19 expression (By similarity). Is a transcriptional repressor of STAR (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Indicus|evm.model.CM009491.1.768 Q2KMM2 TPPC1_RAT 61.194 0.88 0.517241 Trappc1 - Trafficking protein particle complex subunit 1 - Rattus norvegicus (Rat) - Trappc1 gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Indicus|evm.model.CM009491.1.769 P42338 PK3CB_HUMAN 96.636 0.998133 1.00093 PIK3CB - Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform - Homo sapiens (Human) - PIK3CB gene Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Indicus|evm.model.CM009491.1.770 Q0IIF6 FAIM1_BOVIN 99.502 0.990099 1.00498 FAIM - Fas apoptotic inhibitory molecule 1 - Bos taurus (Bovine) - FAIM gene Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. Indicus|evm.model.CM009491.1.771 Q5RDE3 CEP70_PONAB 87.219 0.996546 0.969849 CEP70 - Centrosomal protein of 70 kDa - Pongo abelii (Sumatran orangutan) - CEP70 gene Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle (By similarity). Indicus|evm.model.CM009491.1.772 A0FGR9 ESYT3_HUMAN 83.973 0.997664 0.96614 ESYT3 - Extended synaptotagmin-3 - Homo sapiens (Human) - ESYT3 gene Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Indicus|evm.model.CM009491.1.773 O14807 RASM_HUMAN 99.519 0.990431 1.00481 MRAS - Ras-related protein M-Ras precursor - Homo sapiens (Human) - MRAS gene Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway. Indicus|evm.model.CM009491.1.774 Q86XW9 TXND6_HUMAN 76.149 0.55627 1.88485 NME9 - Thioredoxin domain-containing protein 6 - Homo sapiens (Human) - NME9 gene May be a regulator of microtubule physiology. Indicus|evm.model.CM009491.1.775 Q2KI54 ARMC8_BOVIN 100.000 0.997033 1.00149 ARMC8 - Armadillo repeat-containing protein 8 - Bos taurus (Bovine) - ARMC8 gene Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Indicus|evm.model.CM009491.1.776 Q9UK59 DBR1_HUMAN 88.411 0.979817 1.00184 DBR1 - Lariat debranching enzyme - Homo sapiens (Human) - DBR1 gene Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis. Indicus|evm.model.CM009491.1.777 Q9UNA3 A4GCT_HUMAN 81.846 0.947368 1.00588 A4GNT - Alpha-1,4-N-acetylglucosaminyltransferase - Homo sapiens (Human) - A4GNT gene Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity). Indicus|evm.model.CM009491.1.778 Q5XIA0 DZI1L_RAT 90.419 0.648438 0.329897 Dzip1l - Zinc finger protein DZIP1L - Rattus norvegicus (Rat) - Dzip1l gene Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane. Indicus|evm.model.CM009491.1.779 Q8IYY4 DZI1L_HUMAN 76.125 0.991409 0.758801 DZIP1L - Zinc finger protein DZIP1L - Homo sapiens (Human) - DZIP1L gene Involved in primary cilium formation (PubMed:19852954, PubMed:28530676). Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (PubMed:28530676). Indicus|evm.model.CM009491.1.780 Q0VCN0 CLD18_BOVIN 100.000 0.992366 1.00383 CLDN18 - Claudin-18 - Bos taurus (Bovine) - CLDN18 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009491.1.781 P56856 CLD18_HUMAN 73.973 0.923077 0.298851 CLDN18 - Claudin-18 - Homo sapiens (Human) - CLDN18 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009491.1.783 P61259 SOX14_MACFA 100.000 0.991701 1.00417 SOX14 - Transcription factor SOX-14 - Macaca fascicularis (Crab-eating macaque) - SOX14 gene Acts as a negative regulator of transcription. Indicus|evm.model.CM009491.1.784 Q6UXL0 I20RB_HUMAN 79.630 0.996296 0.868167 IL20RB - Interleukin-20 receptor subunit beta precursor - Homo sapiens (Human) - IL20RB gene The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. Indicus|evm.model.CM009491.1.785 P16333 NCK1_HUMAN 98.939 0.994709 1.00265 NCK1 - Cytoplasmic protein NCK1 - Homo sapiens (Human) - NCK1 gene Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. Indicus|evm.model.CM009491.1.786 Q8TBE7 S35G2_HUMAN 94.903 0.995146 1 SLC35G2 - Solute carrier family 35 member G2 - Homo sapiens (Human) - SLC35G2 gene May play a role in cell proliferation. Indicus|evm.model.CM009491.1.787 Q2TBR6 PFD4_BOVIN 88.889 0.715328 1.02239 PFDN4 - Prefoldin subunit 4 - Bos taurus (Bovine) - PFDN4 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Indicus|evm.model.CM009491.1.788 Q8WVM7 STAG1_HUMAN 99.762 0.998411 1.00079 STAG1 - Cohesin subunit SA-1 - Homo sapiens (Human) - STAG1 gene Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Indicus|evm.model.CM009491.1.789 Q2TBR0 PCCB_BOVIN 99.629 0.996296 1.00186 PCCB - Propionyl-CoA carboxylase beta chain, mitochondrial precursor - Bos taurus (Bovine) - PCCB gene This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). Indicus|evm.model.CM009491.1.790 Q9HCI7 MSL2_HUMAN 98.787 0.99654 1.00173 MSL2 - E3 ubiquitin-protein ligase MSL2 - Homo sapiens (Human) - MSL2 gene Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. Indicus|evm.model.CM009491.1.791 Q06190 P2R3A_HUMAN 90.096 0.998262 1.00087 PPP2R3A - Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha - Homo sapiens (Human) - PPP2R3A gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Indicus|evm.model.CM009491.1.793 P54762 EPHB1_HUMAN 98.030 0.990196 0.207317 EPHB1 - Ephrin type-B receptor 1 precursor - Homo sapiens (Human) - EPHB1 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). Indicus|evm.model.CM009491.1.794 P09759 EPHB1_RAT 98.420 0.934461 0.480691 Ephb1 - Ephrin type-B receptor 1 precursor - Rattus norvegicus (Rat) - Ephb1 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively (By similarity). Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). Indicus|evm.model.CM009491.1.796 Q8CBF3 EPHB1_MOUSE 99.197 0.992 0.254065 Ephb1 - Ephrin type-B receptor 1 precursor - Mus musculus (Mouse) - Ephb1 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (PubMed:27446912). Indicus|evm.model.CM009491.1.797 Q8NBH2 KY_HUMAN 77.644 0.996689 0.913767 KY - Kyphoscoliosis peptidase - Homo sapiens (Human) - KY gene Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity). Indicus|evm.model.CM009491.1.798 Q5NVN6 CEP63_PONAB 87.321 0.691218 1.30499 CEP63 - Centrosomal protein of 63 kDa - Pongo abelii (Sumatran orangutan) - CEP63 gene Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). Indicus|evm.model.CM009491.1.799 Q9BS18 APC13_HUMAN 100.000 0.584 1.68919 ANAPC13 - Anaphase-promoting complex subunit 13 - Homo sapiens (Human) - ANAPC13 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Indicus|evm.model.CM009491.1.800 F1MRK3 AMOL2_BOVIN 99.869 0.997392 1.00131 AMOTL2 - Angiomotin-like protein 2 - Bos taurus (Bovine) - AMOTL2 gene Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity). Indicus|evm.model.CM009491.1.801 P34925 RYK_HUMAN 98.493 0.990654 0.881384 RYK - Tyrosine-protein kinase RYK precursor - Homo sapiens (Human) - RYK gene May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. Indicus|evm.model.CM009491.1.802 Q92959 SO2A1_HUMAN 83.540 0.996899 1.00311 SLCO2A1 - Solute carrier organic anion transporter family member 2A1 - Homo sapiens (Human) - SLCO2A1 gene Transports PGD2, as well as PGE1, PGE2 and PGF2A. Mediates the clearance of prostaglandins from the circulation through uptake across cell membrane which allows cytoplasmic oxidation and prostaglandin signal termination (PubMed:8787677). May mediate the release of newly synthesized prostaglandins from cells and the transepithelial transport of prostaglandins (Probable). Indicus|evm.model.CM009491.1.803 P61294 RAB6B_MOUSE 100.000 0.990431 1.00481 Rab6b - Ras-related protein Rab-6B - Mus musculus (Mouse) - Rab6b gene Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity). Indicus|evm.model.CM009491.1.804 Q9Y5M8 SRPRB_HUMAN 92.989 0.909091 1.09594 SRPRB - Signal recognition particle receptor subunit beta - Homo sapiens (Human) - SRPRB gene Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity). Indicus|evm.model.CM009491.1.805 Q29443 TRFE_BOVIN 97.860 0.506146 1.96449 TF - Serotransferrin precursor - Bos taurus (Bovine) - TF gene Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Indicus|evm.model.CM009491.1.806 Q92547 TOPB1_HUMAN 89.488 0.957179 1.04336 TOPBP1 - DNA topoisomerase 2-binding protein 1 - Homo sapiens (Human) - TOPBP1 gene Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042). Indicus|evm.model.CM009491.1.807 Q9UKY7 CDV3_HUMAN 91.085 0.992248 1 CDV3 - Protein CDV3 homolog - Homo sapiens (Human) - CDV3 gene cytoplasm, cytosol, plasma membrane Indicus|evm.model.CM009491.1.808 Q28177 BFSP2_BOVIN 99.422 0.977273 0.424096 BFSP2 - Phakinin - Bos taurus (Bovine) - BFSP2 gene Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Plays a role in maintenance of retinal lens optical clarity (By similarity). Indicus|evm.model.CM009491.1.809 Q28177 BFSP2_BOVIN 87.629 0.717472 0.648193 BFSP2 - Phakinin - Bos taurus (Bovine) - BFSP2 gene Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Plays a role in maintenance of retinal lens optical clarity (By similarity). Indicus|evm.model.CM009491.1.810 A6QLF8 TM108_BOVIN 99.657 0.996575 1.00172 TMEM108 - Transmembrane protein 108 - Bos taurus (Bovine) - TMEM108 gene Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. Indicus|evm.model.CM009491.1.811 P63172 DYLT1_HUMAN 100.000 0.982456 1.00885 DYNLT1 - Dynein light chain Tctex-type 1 - Homo sapiens (Human) - DYNLT1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. Indicus|evm.model.CM009491.1.812 Q7Z494 NPHP3_HUMAN 95.192 0.998498 1.0015 NPHP3 - Nephrocystin-3 - Homo sapiens (Human) - NPHP3 gene Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. Indicus|evm.model.CM009491.1.813 A7MAZ3 UBA5_BOVIN 99.752 0.995062 1.00248 UBA5 - Ubiquitin-like modifier-activating enzyme 5 - Bos taurus (Bovine) - UBA5 gene E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). Indicus|evm.model.CM009491.1.814 Q709F0 ACD11_HUMAN 77.559 0.938 0.641026 ACAD11 - Acyl-CoA dehydrogenase family member 11 - Homo sapiens (Human) - ACAD11 gene Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA (PubMed:21237683). Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain (Probable). Indicus|evm.model.CM009491.1.815 P35350 ACKR4_BOVIN 99.714 0.994302 1.00286 ACKR4 - Atypical chemokine receptor 4 - Bos taurus (Bovine) - ACKR4 gene Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus (By similarity). Indicus|evm.model.CM009491.1.816 Q5R778 ACD11_PONAB 85.526 0.991266 0.293214 ACAD11 - Acyl-CoA dehydrogenase family member 11 - Pongo abelii (Sumatran orangutan) - ACAD11 gene Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain. Indicus|evm.model.CM009491.1.817 O75165 DJC13_HUMAN 97.459 0.999109 1.00045 DNAJC13 - DnaJ homolog subfamily C member 13 - Homo sapiens (Human) - DNAJC13 gene Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499). Indicus|evm.model.CM009491.1.818 A6H730 PPAP_BOVIN 99.474 0.902381 1.08527 ACP3 - Prostatic acid phosphatase precursor - Bos taurus (Bovine) - ACP3 gene A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity). Indicus|evm.model.CM009491.1.819 Q96L42 KCNH8_HUMAN 99.112 0.439948 0.69196 KCNH8 - Potassium voltage-gated channel subfamily H member 8 - Homo sapiens (Human) - KCNH8 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Indicus|evm.model.CM009491.1.820 Q8BLR2 CPNE4_MOUSE 100.000 0.1373 0.78456 Cpne4 - Copine-4 - Mus musculus (Mouse) - Cpne4 gene Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Indicus|evm.model.CM009491.1.821 Q9H2P0 ADNP_HUMAN 75.325 0.122549 0.555354 ADNP - Activity-dependent neuroprotector homeobox protein - Homo sapiens (Human) - ADNP gene Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Indicus|evm.model.CM009491.1.822 Q9H2P0 ADNP_HUMAN 88.889 0.839623 0.0961887 ADNP - Activity-dependent neuroprotector homeobox protein - Homo sapiens (Human) - ADNP gene Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Indicus|evm.model.CM009491.1.823 Q8BLR2 CPNE4_MOUSE 99.198 0.99006 0.903052 Cpne4 - Copine-4 - Mus musculus (Mouse) - Cpne4 gene Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Indicus|evm.model.CM009491.1.824 Q3ZBX6 RM03_BOVIN 100.000 0.994269 1.00287 MRPL3 - 39S ribosomal protein L3, mitochondrial precursor - Bos taurus (Bovine) - MRPL3 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009491.1.825 A1A4Q9 NUD16_BOVIN 100.000 0.989796 1.00513 NUDT16 - U8 snoRNA-decapping enzyme - Bos taurus (Bovine) - NUDT16 gene RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Indicus|evm.model.CM009491.1.826 Q8WNU8 NEK11_MACFA 82.258 0.401316 0.238619 NEK11 - Serine/threonine-protein kinase Nek11 - Macaca fascicularis (Crab-eating macaque) - NEK11 gene Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Indicus|evm.model.CM009491.1.827 Q8NG66 NEK11_HUMAN 70.480 0.85 0.868217 NEK11 - Serine/threonine-protein kinase Nek11 - Homo sapiens (Human) - NEK11 gene Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Indicus|evm.model.CM009491.1.828 Q2TB18 ASTE1_HUMAN 78.838 0.982353 1.00147 ASTE1 - Protein asteroid homolog 1 - Homo sapiens (Human) - ASTE1 gene Possible role in EGF receptor signaling. Indicus|evm.model.CM009491.1.829 P57709 AT2C1_BOVIN 99.891 0.996739 0.965373 ATP2C1 - Calcium-transporting ATPase type 2C member 1 - Bos taurus (Bovine) - ATP2C1 gene ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (By similarity). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (By similarity). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (By similarity). Indicus|evm.model.CM009491.1.830 Q0P5F2 PSMG1_BOVIN 99.653 0.99308 1.00347 PSMG1 - Proteasome assembly chaperone 1 - Bos taurus (Bovine) - PSMG1 gene Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity). Indicus|evm.model.CM009491.1.831 Q9NSI6 BRWD1_HUMAN 89.013 0.999139 1.00172 BRWD1 - Bromodomain and WD repeat-containing protein 1 - Homo sapiens (Human) - BRWD1 gene May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Indicus|evm.model.CM009491.1.832 P02316 HMGN1_BOVIN 96.154 0.394872 1.93069 HMGN1 - Non-histone chromosomal protein HMG-14 - Bos taurus (Bovine) - HMGN1 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). Indicus|evm.model.CM009491.1.833 Q3SZ26 GET1_BOVIN 100.000 0.865 1.14943 GET1 - Guided entry of tail-anchored proteins factor 1 - Bos taurus (Bovine) - GET1 gene Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG. Indicus|evm.model.CM009491.1.834 A7E3D8 LCA5L_BOVIN 92.629 0.979536 1.09403 LCA5L - Lebercilin-like protein - Bos taurus (Bovine) - LCA5L gene axoneme, intraciliary transport Indicus|evm.model.CM009491.1.835 P55822 SH3BG_HUMAN 90.370 0.770115 0.728033 SH3BGR - SH3 domain-binding glutamic acid-rich protein - Homo sapiens (Human) - SH3BGR gene cytosol, protein-containing complex assembly Indicus|evm.model.CM009491.1.836 Q9Y2C3 B3GT5_HUMAN 67.638 0.987179 1.00645 B3GALT5 - Beta-1,3-galactosyltransferase 5 - Homo sapiens (Human) - B3GALT5 gene Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. Indicus|evm.model.CM009491.1.837 Q9NSI5 IGSF5_HUMAN 64.151 0.649231 0.798526 IGSF5 - Immunoglobulin superfamily member 5 - Homo sapiens (Human) - IGSF5 gene Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity). Indicus|evm.model.CM009491.1.838 O60469 DSCAM_HUMAN 90.517 0.775588 0.781809 DSCAM - Down syndrome cell adhesion molecule precursor - Homo sapiens (Human) - DSCAM gene Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). Indicus|evm.model.CM009491.1.839 O60469 DSCAM_HUMAN 98.532 0.9792 0.310636 DSCAM - Down syndrome cell adhesion molecule precursor - Homo sapiens (Human) - DSCAM gene Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). Indicus|evm.model.CM009491.1.841 O60469 DSCAM_HUMAN 95.597 0.728111 0.107853 DSCAM - Down syndrome cell adhesion molecule precursor - Homo sapiens (Human) - DSCAM gene Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). Indicus|evm.model.CM009491.1.842 Q9Y5Z0 BACE2_HUMAN 90.763 0.95534 0.994208 BACE2 - Beta-secretase 2 precursor - Homo sapiens (Human) - BACE2 gene Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). Indicus|evm.model.CM009491.1.843 P15475 ACTB_XENBO 86.000 0.381323 0.683511 actb - Actin, cytoplasmic 1 - Xenopus borealis (Kenyan clawed frog) - actb gene Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Indicus|evm.model.CM009491.1.844 Q9D309 FAM3B_MOUSE 84.549 0.698795 1.41277 Fam3b - Protein FAM3B precursor - Mus musculus (Mouse) - Fam3b gene Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Indicus|evm.model.CM009491.1.845 Q9BDI7 MX2_BOVIN 99.859 0.997187 1.00141 MX2 - Interferon-induced GTP-binding protein Mx2 - Bos taurus (Bovine) - MX2 gene Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV). Indicus|evm.model.CM009491.1.846 P79135 MX1_BOVIN 99.083 0.996947 1.0108 MX1 - Interferon-induced GTP-binding protein Mx1 - Bos taurus (Bovine) - MX1 gene Interferon-induced dynamin-like GTPase with antiviral activity against rabies virus (RABV), vesicular stomatitis virus (VSV) and murine pneumonia virus (MPV). Isoform 1 but not isoform 2 shows antiviral activity against vesicular stomatitis virus (VSV). Indicus|evm.model.CM009491.1.847 O15393 TMPS2_HUMAN 78.615 0.731634 1.35569 TMPRSS2 - Transmembrane protease serine 2 precursor - Homo sapiens (Human) - TMPRSS2 gene Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). Indicus|evm.model.CM009491.1.849 Q9ERK0 RIPK4_MOUSE 88.041 0.997455 1 Ripk4 - Receptor-interacting serine/threonine-protein kinase 4 - Mus musculus (Mouse) - Ripk4 gene Involved in stratified epithelial development (By similarity). It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. Indicus|evm.model.CM009491.1.850 P57071 PRD15_HUMAN 90.401 0.844125 0.830126 PRDM15 - PR domain zinc finger protein 15 - Homo sapiens (Human) - PRDM15 gene Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264). Indicus|evm.model.CM009491.1.851 Q9Y426 C2CD2_HUMAN 74.749 0.995702 1.00287 C2CD2 - C2 domain-containing protein 2 - Homo sapiens (Human) - C2CD2 gene cytosol, nucleus Indicus|evm.model.CM009491.1.852 Q9ULJ3 ZBT21_HUMAN 73.714 0.998092 0.983114 ZBTB21 - Zinc finger and BTB domain-containing protein 21 - Homo sapiens (Human) - ZBTB21 gene Acts as a transcription repressor. Indicus|evm.model.CM009491.1.854 Q5DID0 UROL1_HUMAN 65.689 0.889034 1.16237 UMODL1 - Uromodulin-like 1 precursor - Homo sapiens (Human) - UMODL1 gene apical plasma membrane, cell surface, extracellular space, extracellular matrix structural constituent, neutrophil migration Indicus|evm.model.CM009491.1.855 Q64343 ABCG1_MOUSE 93.862 0.996997 1 Abcg1 - ATP-binding cassette sub-family G member 1 - Mus musculus (Mouse) - Abcg1 gene Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:14668945). The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (By similarity). Indicus|evm.model.CM009491.1.856 A8YXX7 TFF3_BOVIN 100.000 0.833333 1.18519 TFF3 - Trefoil factor 3 precursor - Bos taurus (Bovine) - TFF3 gene Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity). Indicus|evm.model.CM009491.1.857 P01359 TFF2_PIG 79.091 0.838462 1.02362 TFF2 - Trefoil factor 2 precursor - Sus scrofa (Pig) - TFF2 gene Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. Indicus|evm.model.CM009491.1.858 Q863T4 TFF1_CANLF 65.789 0.386598 2.39506 TFF1 - Trefoil factor 1 precursor - Canis lupus familiaris (Dog) - TFF1 gene Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. Indicus|evm.model.CM009491.1.859 P57727 TMPS3_HUMAN 90.423 0.921649 1.06828 TMPRSS3 - Transmembrane protease serine 3 - Homo sapiens (Human) - TMPRSS3 gene Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). Indicus|evm.model.CM009491.1.860 Q3V3E1 UBS3A_MOUSE 79.487 0.996769 0.991987 Ubash3a - Ubiquitin-associated and SH3 domain-containing protein A - Mus musculus (Mouse) - Ubash3a gene Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. Indicus|evm.model.CM009491.1.861 Q8WYR4 RSPH1_HUMAN 81.029 0.987055 1 RSPH1 - Radial spoke head 1 homolog - Homo sapiens (Human) - RSPH1 gene May play an important role in male meiosis (By similarity). It is necessary for proper building of the axonemal central pair and radial spokes. Indicus|evm.model.CM009491.1.862 P57057 G6PT2_HUMAN 87.242 0.996255 1.00188 SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. Indicus|evm.model.CM009491.1.863 O70628 PDE9A_MOUSE 91.031 0.979284 0.994382 Pde9a - High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A - Mus musculus (Mouse) - Pde9a gene Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:9624145). Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (PubMed:22328573, PubMed:24746365). Indicus|evm.model.CM009491.1.864 A7E3S5 WDR4_BOVIN 99.758 0.995181 1.00242 WDR4 - tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 - Bos taurus (Bovine) - WDR4 gene Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs. Also required for methylation of a specific subset of miRNAs, such as let-7. Acts as a regulator of embryonic stem cell self-renewal and differentiation. Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1. Indicus|evm.model.CM009491.1.865 P25712 NDUV3_BOVIN 100.000 0.105042 4.36697 NDUFV3 - NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial precursor - Bos taurus (Bovine) - NDUFV3 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I. Indicus|evm.model.CM009491.1.866 Q2HJ84 PKNX1_BOVIN 100.000 0.995423 1.00229 PKNOX1 - Homeobox protein PKNOX1 - Bos taurus (Bovine) - PKNOX1 gene Activates transcription in the presence of PBX1A and HOXA1. Indicus|evm.model.CM009491.1.867 P35520 CBS_HUMAN 86.980 0.965035 1.03811 CBS - Cystathionine beta-synthase - Homo sapiens (Human) - CBS gene Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). Indicus|evm.model.CM009491.1.868 A1A4K8 U2AF1_BOVIN 97.046 0.991597 1.00422 U2AF1 - Splicing factor U2AF 35 kDa subunit - Bos taurus (Bovine) - U2AF1 gene Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity). Indicus|evm.model.CM009491.1.869 P02470 CRYAA_BOVIN 100.000 0.939891 1.0578 CRYAA - Alpha-crystallin A chain - Bos taurus (Bovine) - CRYAA gene Contributes to the transparency and refractive index of the lens (By similarity). Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions (PubMed:20440841). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Indicus|evm.model.CM009491.1.873 Q17QV3 SUMO3_BOVIN 100.000 0.980952 1.00962 SUMO3 - Small ubiquitin-related modifier 3 precursor - Bos taurus (Bovine) - SUMO3 gene Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity). Indicus|evm.model.CM009491.1.874 Q5NVI6 PTTG_PONAB 80.000 0.988636 0.977778 PTTG1IP - Pituitary tumor-transforming gene 1 protein-interacting protein precursor - Pongo abelii (Sumatran orangutan) - PTTG1IP gene May facilitate PTTG1 nuclear translocation. Indicus|evm.model.CM009491.1.875 P32592 ITB2_BOVIN 96.619 0.914005 1.05852 ITGB2 - Integrin beta-2 precursor - Bos taurus (Bovine) - ITGB2 gene Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. Indicus|evm.model.CM009491.1.876 P58468 F207A_MOUSE 70.642 0.986364 1.00457 Fam207a - Protein FAM207A - Mus musculus (Mouse) - Fam207a gene Indicus|evm.model.CM009491.1.878 P51400 RED1_RAT 89.170 0.890585 1.10549 Adarb1 - Double-stranded RNA-specific editase 1 - Rattus norvegicus (Rat) - Adarb1 gene Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently (By similarity). Can inhibit cell proliferation and migration and can stimulate exocytosis. Indicus|evm.model.CM009491.1.879 Q6EV56 OFUT2_PANTR 91.627 0.466443 2.08392 POFUT2 - GDP-fucose protein O-fucosyltransferase 2 precursor - Pan troglodytes (Chimpanzee) - POFUT2 gene Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombosporin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13. O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Indicus|evm.model.CM009491.1.880 Q9UJW3 DNM3L_HUMAN 78.378 0.520509 1.83161 DNMT3L - DNA (cytosine-5)-methyltransferase 3-like - Homo sapiens (Human) - DNMT3L gene Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327). Plays a key role in embryonic stem cells and germ cells (By similarity). In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity). Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (By similarity). While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity). Indicus|evm.model.CM009491.1.881 O43918 AIRE_HUMAN 74.176 0.974026 0.988991 AIRE - Autoimmune regulator - Homo sapiens (Human) - AIRE gene Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (PubMed:26084028). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program. Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression. Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes. In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection. In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (By similarity). Indicus|evm.model.CM009491.1.882 A1A4J1 PFKAL_BOVIN 99.872 0.997439 1.00128 PFKL - ATP-dependent 6-phosphofructokinase, liver type - Bos taurus (Bovine) - PFKL gene Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). Indicus|evm.model.CM009491.1.883 O43822 CF410_HUMAN 73.930 0.992218 1.00391 CFAP410 - Cilia- and flagella-associated protein 410 - Homo sapiens (Human) - CFAP410 gene Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). Indicus|evm.model.CM009491.1.885 O94759 TRPM2_HUMAN 79.412 0.992 0.998004 TRPM2 - Transient receptor potential cation channel subfamily M member 2 - Homo sapiens (Human) - TRPM2 gene Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:28775320, PubMed:29745897, PubMed:30467180). Functions as ligand-gated ion channel (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:30467180). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:29745897, PubMed:30467180). Extracellular calcium passes through the channel and increases channel activity (PubMed:19171771). Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:11960981, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:30467180). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606). Indicus|evm.model.CM009491.1.886 A6H793 LRRC3_BOVIN 100.000 0.980843 1.01556 LRRC3 - Leucine-rich repeat-containing protein 3 precursor - Bos taurus (Bovine) - LRRC3 gene Indicus|evm.model.CM009491.1.888 Q8WU66 TSEAR_HUMAN 84.522 0.864458 0.992526 TSPEAR - Thrombospondin-type laminin G domain and EAR repeat-containing protein precursor - Homo sapiens (Human) - TSPEAR gene Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway (PubMed:27736875). May play a role in development or function of the auditory system (PubMed:22678063). Indicus|evm.model.CM009491.1.893 P60372 KR104_HUMAN 74.545 0.529101 0.471322 KRTAP10-4 - Keratin-associated protein 10-4 - Homo sapiens (Human) - KRTAP10-4 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Indicus|evm.model.CM009491.1.896 P60409 KR107_HUMAN 64.151 0.47619 0.283784 KRTAP10-7 - Keratin-associated protein 10-7 - Homo sapiens (Human) - KRTAP10-7 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Indicus|evm.model.CM009491.1.897 Q17QG5 UB2G2_BOVIN 100.000 0.979167 0.581818 UBE2G2 - Ubiquitin-conjugating enzyme E2 G2 - Bos taurus (Bovine) - UBE2G2 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation. Indicus|evm.model.CM009491.1.898 P57059 SIK1_HUMAN 85.274 0.878788 0.842912 SIK1 - Serine/threonine-protein kinase SIK1 - Homo sapiens (Human) - SIK1 gene Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). Indicus|evm.model.CM009491.1.900 O75031 HSF2B_HUMAN 93.114 0.99403 1.00299 HSF2BP - Heat shock factor 2-binding protein - Homo sapiens (Human) - HSF2BP gene Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed:31242413). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity). Required for proper recombinase recruitment in female meiosis (By similarity). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). May be involved in modulating HSF2 activation in testis (PubMed:9651507). Indicus|evm.model.CM009491.1.901 Q14684 RRP1B_HUMAN 67.678 0.99729 0.973615 RRP1B - Ribosomal RNA processing protein 1 homolog B - Homo sapiens (Human) - RRP1B gene Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). Indicus|evm.model.CM009491.1.902 Q0II59 PDXK_BOVIN 100.000 0.99361 1.00321 PDXK - Pyridoxal kinase - Bos taurus (Bovine) - PDXK gene Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity). Indicus|evm.model.CM009491.1.903 P35478 CYTX_BOVIN 99.010 0.980392 1.0099 Stefin-C - Bos taurus (Bovine) Indicus|evm.model.CM009491.1.904 P25417 CYTB_BOVIN 100.000 0.979798 1.0102 CSTB - Cystatin-B - Bos taurus (Bovine) - CSTB gene This is an intracellular thiol proteinase inhibitor. Indicus|evm.model.CM009491.1.905 P56183 RRP1_MOUSE 77.381 0.599045 0.848178 Rrp1 - Ribosomal RNA processing protein 1 homolog A - Mus musculus (Mouse) - Rrp1 gene Plays a critical role in the generation of 28S rRNA. Indicus|evm.model.CM009491.1.907 Q9NRZ7 PLCC_HUMAN 93.351 0.994695 1.00266 AGPAT3 - 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma - Homo sapiens (Human) - AGPAT3 gene Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity). Indicus|evm.model.CM009491.1.909 P48553 TPC10_HUMAN 89.740 0.998423 1.00715 TRAPPC10 - Trafficking protein particle complex subunit 10 - Homo sapiens (Human) - TRAPPC10 gene Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether. Indicus|evm.model.CM009491.1.910 Q15269 PWP2_HUMAN 90.680 0.988043 1.00109 PWP2 - Periodic tryptophan protein 2 homolog - Homo sapiens (Human) - PWP2 gene nucleoplasm, Pwp2p-containing subcomplex of 90S preribosome, small-subunit processome, RNA binding, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit assembly, rRNA processing Indicus|evm.model.CM009491.1.911 A0A0B4J2D5 GAL3B_HUMAN 82.482 0.992647 1.01493 GATD3B - Glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial precursor - Homo sapiens (Human) - GATD3B gene mitochondrion Indicus|evm.model.CM009491.1.913 P39060 COIA1_HUMAN 81.169 0.181228 0.965792 COL18A1 - Collagen alpha-1(XVIII) chain precursor - Homo sapiens (Human) - COL18A1 gene Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Indicus|evm.model.CM009491.1.914 P41440 S19A1_HUMAN 70.058 0.788401 1.07953 SLC19A1 - Reduced folate transporter - Homo sapiens (Human) - SLC19A1 gene Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides (PubMed:7826387, PubMed:9041240, PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:31126740, PubMed:31511694). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803). Also able to mediate the import of antifolate drug methotrexate (PubMed:7615551, PubMed:7641195, PubMed:9767079, PubMed:22554803). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP (PubMed:31126740, PubMed:31511694). Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803). Indicus|evm.model.CM009491.1.916 P57722 PCBP3_MOUSE 97.844 0.994624 1.0027 Pcbp3 - Poly(rC)-binding protein 3 - Mus musculus (Mouse) - Pcbp3 gene Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Indicus|evm.model.CM009491.1.918 Q04857 CO6A1_MOUSE 91.798 0.983463 1.00293 Col6a1 - Collagen alpha-1(VI) chain precursor - Mus musculus (Mouse) - Col6a1 gene Collagen VI acts as a cell-binding protein. Indicus|evm.model.CM009491.1.919 Q02788 CO6A2_MOUSE 92.460 0.788924 0.925532 Col6a2 - Collagen alpha-2(VI) chain precursor - Mus musculus (Mouse) - Col6a2 gene Collagen VI acts as a cell-binding protein. Indicus|evm.model.CM009491.1.920 Q02788 CO6A2_MOUSE 85.930 0.876106 0.218569 Col6a2 - Collagen alpha-2(VI) chain precursor - Mus musculus (Mouse) - Col6a2 gene Collagen VI acts as a cell-binding protein. Indicus|evm.model.CM009491.1.921 P53603 FTCD_PIG 88.889 0.994465 1.00185 FTCD - Formimidoyltransferase-cyclodeaminase - Sus scrofa (Pig) - FTCD gene Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Indicus|evm.model.CM009491.1.922 Q9D9W0 SPC1L_MOUSE 86.589 0.994186 1.00585 Spatc1l - Speriolin-like protein - Mus musculus (Mouse) - Spatc1l gene centrosome, sperm connecting piece, identical protein binding, protein kinase A regulatory subunit binding, actin polymerization or depolymerization, positive regulation of cAMP-dependent protein kinase activity, positive regulation of protein kinase A signaling, positive regulation of protein phosphorylation, spermatogenesis Indicus|evm.model.CM009491.1.923 P84466 LSS_BOVIN 99.454 0.997271 1.00137 LSS - Lanosterol synthase - Bos taurus (Bovine) - LSS gene Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14678783). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (By similarity). Indicus|evm.model.CM009491.1.924 O60318 GANP_HUMAN 83.023 0.99899 1 MCM3AP - Germinal-center associated nuclear protein - Homo sapiens (Human) - MCM3AP gene As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:23591820, PubMed:22307388). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). Indicus|evm.model.CM009491.1.925 P58557 YBEY_HUMAN 74.390 0.987879 0.988024 YBEY - Endoribonuclease YbeY - Homo sapiens (Human) - YBEY gene Single strand-specific metallo-endoribonuclease involved in rRNA maturation. Indicus|evm.model.CM009491.1.926 P58505 CU058_HUMAN 60.633 0.655063 0.981366 C21orf58 - Uncharacterized protein C21orf58 - Homo sapiens (Human) - C21orf58 gene Indicus|evm.model.CM009491.1.927 O95613 PCNT_HUMAN 64.773 0.027584 0.945444 PCNT - Pericentrin - Homo sapiens (Human) - PCNT gene Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. Indicus|evm.model.CM009491.1.928 Q14689 DIP2A_HUMAN 90.909 0.998722 0.996181 DIP2A - Disco-interacting protein 2 homolog A - Homo sapiens (Human) - DIP2A gene Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). Indicus|evm.model.CM009491.1.930 P02638 S100B_BOVIN 100.000 0.978495 1.01087 S100B - Protein S100-B - Bos taurus (Bovine) - S100B gene Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity). Indicus|evm.model.CM009491.1.931 P55345 ANM2_HUMAN 86.175 0.80334 1.2448 PRMT2 - Protein arginine N-methyltransferase 2 - Homo sapiens (Human) - PRMT2 gene Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. Indicus|evm.model.CM009491.1.932 O02747 AHR_RABIT 53.498 0.60281 0.924439 AHR - Aryl hydrocarbon receptor - Oryctolagus cuniculus (Rabbit) - AHR gene Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:9022676). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists. Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands. Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity). Indicus|evm.model.CM009491.1.933 Q1RMS8 FBX25_BOVIN 99.721 0.994429 1.0056 FBXO25 - F-box only protein 25 - Bos taurus (Bovine) - FBXO25 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). Indicus|evm.model.CM009491.1.934 Q86YL5 TDRP_HUMAN 77.241 0.761905 1.02162 TDRP - Testis development-related protein - Homo sapiens (Human) - TDRP gene Contributes to normal sperm motility, but not essential for male fertility. Indicus|evm.model.CM009491.1.935 Q96NY7 CLIC6_HUMAN 83.417 0.859031 0.322443 CLIC6 - Chloride intracellular channel protein 6 - Homo sapiens (Human) - CLIC6 gene May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). Indicus|evm.model.CM009491.1.936 Q01196 RUNX1_HUMAN 98.661 0.861272 1.1457 RUNX1 - Runt-related transcription factor 1 - Homo sapiens (Human) - RUNX1 gene Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). Indicus|evm.model.CM009491.1.939 Q9NVD3 SETD4_HUMAN 80.909 0.995465 1.00227 SETD4 - SET domain-containing protein 4 - Homo sapiens (Human) - SETD4 gene Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response (PubMed:31308046). Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of proinflammatory cytokines IL6 and TNF-alpha (By similarity). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity). Indicus|evm.model.CM009491.1.940 Q3SZD7 CBR1_BOVIN 97.938 0.755906 0.458484 CBR1 - Carbonyl reductase [NADPH] 1 - Bos taurus (Bovine) - CBR1 gene NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). Indicus|evm.model.CM009491.1.941 Q3SZD7 CBR1_BOVIN 95.307 0.992806 1.00361 CBR1 - Carbonyl reductase [NADPH] 1 - Bos taurus (Bovine) - CBR1 gene NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). Indicus|evm.model.CM009491.1.942 Q3SZD7 CBR1_BOVIN 58.031 0.89375 0.577617 CBR1 - Carbonyl reductase [NADPH] 1 - Bos taurus (Bovine) - CBR1 gene NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). Indicus|evm.model.CM009491.1.943 Q3SZD7 CBR1_BOVIN 96.429 0.195294 1.5343 CBR1 - Carbonyl reductase [NADPH] 1 - Bos taurus (Bovine) - CBR1 gene NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). Indicus|evm.model.CM009491.1.944 Q8K354 CBR3_MOUSE 89.892 0.992806 1.00361 Cbr3 - Carbonyl reductase [NADPH] 3 - Mus musculus (Mouse) - Cbr3 gene Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). Indicus|evm.model.CM009491.1.945 Q9Y3R5 DOP2_HUMAN 86.545 0.480929 0.992602 DOP1B - Protein dopey-2 - Homo sapiens (Human) - DOP1B gene May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. Indicus|evm.model.CM009491.1.946 Q14149 MORC3_HUMAN 86.185 0.997856 0.99361 MORC3 - MORC family CW-type zinc finger protein 3 - Homo sapiens (Human) - MORC3 gene Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). Indicus|evm.model.CM009491.1.947 Q13112 CAF1B_HUMAN 84.321 0.994792 1.03041 CHAF1B - Chromatin assembly factor 1 subunit B - Homo sapiens (Human) - CHAF1B gene Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. Indicus|evm.model.CM009491.1.948 Q9Z0S3 CLD14_MOUSE 84.615 0.717949 0.979079 Cldn14 - Claudin-14 - Mus musculus (Mouse) - Cldn14 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009491.1.949 Q14190 SIM2_HUMAN 99.145 0.97479 0.178411 SIM2 - Single-minded homolog 2 - Homo sapiens (Human) - SIM2 gene Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. Indicus|evm.model.CM009491.1.950 Q61079 SIM2_MOUSE 88.916 0.798839 0.78691 Sim2 - Single-minded homolog 2 - Mus musculus (Mouse) - Sim2 gene Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. Indicus|evm.model.CM009491.1.951 P50747 BPL1_HUMAN 74.623 0.838747 1.18733 HLCS - Biotin--protein ligase - Homo sapiens (Human) - HLCS gene Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. Indicus|evm.model.CM009491.1.952 Q924S9 DSCR6_MOUSE 72.881 0.633333 1.18421 Ripply3 - Protein ripply3 - Mus musculus (Mouse) - Ripply3 gene Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives. Indicus|evm.model.CM009491.1.953 P57054 PIGP_HUMAN 94.531 0.984496 0.816456 PIGP - Phosphatidylinositol N-acetylglucosaminyltransferase subunit P - Homo sapiens (Human) - PIGP gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Indicus|evm.model.CM009491.1.954 P53804 TTC3_HUMAN 80.249 0.998993 0.980741 TTC3 - E3 ubiquitin-protein ligase TTC3 - Homo sapiens (Human) - TTC3 gene E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). Indicus|evm.model.CM009491.1.955 O14972 VP26C_HUMAN 93.939 0.993289 1.00337 VPS26C - Vacuolar protein sorting-associated protein 26C - Homo sapiens (Human) - VPS26C gene Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Indicus|evm.model.CM009491.1.956 Q13627 DYR1A_HUMAN 99.607 0.997382 1.00131 DYRK1A - Dual specificity tyrosine-phosphorylation-regulated kinase 1A - Homo sapiens (Human) - DYRK1A gene Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). Indicus|evm.model.CM009491.1.958 P48051 KCNJ6_HUMAN 99.754 0.995098 0.964539 KCNJ6 - G protein-activated inward rectifier potassium channel 2 - Homo sapiens (Human) - KCNJ6 gene This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Indicus|evm.model.CM009491.1.962 Q99712 KCJ15_HUMAN 97.067 0.994681 1.00267 KCNJ15 - ATP-sensitive inward rectifier potassium channel 15 - Homo sapiens (Human) - KCNJ15 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Indicus|evm.model.CM009491.1.963 P11308 ERG_HUMAN 92.276 0.995614 0.951983 ERG - Transcriptional regulator ERG - Homo sapiens (Human) - ERG gene Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. Indicus|evm.model.CM009491.1.965 A1A4L6 ETS2_BOVIN 96.861 0.993119 0.92766 ETS2 - Protein C-ets-2 - Bos taurus (Bovine) - ETS2 gene Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). Indicus|evm.model.CM009491.1.969 Q99570 PI3R4_HUMAN 96.760 0.998528 1.00074 PIK3R4 - Phosphoinositide 3-kinase regulatory subunit 4 - Homo sapiens (Human) - PIK3R4 gene Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Indicus|evm.model.CM009491.1.970 A6NMZ7 CO6A6_HUMAN 83.208 0.950758 1.04993 COL6A6 - Collagen alpha-6(VI) chain precursor - Homo sapiens (Human) - COL6A6 gene Collagen VI acts as a cell-binding protein. Indicus|evm.model.CM009491.1.971 A8TX70 CO6A5_HUMAN 75.354 0.137285 0.980497 COL6A5 - Collagen alpha-5(VI) chain precursor - Homo sapiens (Human) - COL6A5 gene Collagen VI acts as a cell-binding protein. Indicus|evm.model.CM009491.1.972 A2AX52 CO6A4_MOUSE 67.633 0.97139 0.635773 Col6a4 - Collagen alpha-4(VI) chain precursor - Mus musculus (Mouse) - Col6a4 gene Collagen VI acts as a cell-binding protein. Indicus|evm.model.CM009491.1.973 A2AX52 CO6A4_MOUSE 59.783 0.80531 0.0489389 Col6a4 - Collagen alpha-4(VI) chain precursor - Mus musculus (Mouse) - Col6a4 gene Collagen VI acts as a cell-binding protein. Indicus|evm.model.CM009491.1.974 A0FKG7 CAN7_PIG 97.294 0.997543 1.00123 CAPN7 - Calpain-7 - Sus scrofa (Pig) - CAPN7 gene Calcium-regulated non-lysosomal thiol-protease. Indicus|evm.model.CM009491.1.975 O60239 3BP5_HUMAN 83.619 0.928406 0.951648 SH3BP5 - SH3 domain-binding protein 5 - Homo sapiens (Human) - SH3BP5 gene Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. Indicus|evm.model.CM009491.1.976 Q791B0 UBL5_PSAOB 98.630 0.972973 1.0137 UBL5 - Ubiquitin-like protein 5 - Psammomys obesus (Fat sand rat) - UBL5 gene Indicus|evm.model.CM009491.1.977 Q5RDV8 METL6_PONAB 92.171 0.982456 1.01064 METTL6 - tRNA N(3)-methylcytidine methyltransferase METTL6 - Pongo abelii (Sumatran orangutan) - METTL6 gene S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser). Indicus|evm.model.CM009491.1.978 Q9D4C5 EAF1_MOUSE 93.704 0.992453 0.988806 Eaf1 - ELL-associated factor 1 - Mus musculus (Mouse) - Eaf1 gene Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Indicus|evm.model.CM009491.1.979 Q9Y215 COLQ_HUMAN 88.671 0.995652 1.01099 COLQ - Acetylcholinesterase collagenic tail peptide precursor - Homo sapiens (Human) - COLQ gene Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina. Indicus|evm.model.CM009491.1.980 Q9UJ83 HACL1_HUMAN 88.985 0.996564 1.00692 HACL1 - 2-hydroxyacyl-CoA lyase 1 - Homo sapiens (Human) - HACL1 gene Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:28289220, PubMed:21708296, PubMed:10468558). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:28289220, PubMed:21708296, PubMed:10468558). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). Indicus|evm.model.CM009491.1.981 A6QQ07 BTD_BOVIN 99.429 0.996198 1.0019 BTD - Biotinidase precursor - Bos taurus (Bovine) - BTD gene Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. Indicus|evm.model.CM009491.1.982 O15084 ANR28_HUMAN 98.372 0.962177 1.02944 ANKRD28 - Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A - Homo sapiens (Human) - ANKRD28 gene Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. Indicus|evm.model.CM009491.1.985 Q8N3T1 GLT15_HUMAN 73.684 0.99686 0.99687 GALNT15 - Polypeptide N-acetylgalactosaminyltransferase 15 - Homo sapiens (Human) - GALNT15 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate. Indicus|evm.model.CM009491.1.986 Q1LZC9 DPH3_BOVIN 100.000 0.975904 1.0122 DPH3 - DPH3 homolog - Bos taurus (Bovine) - DPH3 gene Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Indicus|evm.model.CM009491.1.987 Q58DM7 OXND1_BOVIN 98.382 0.993548 1.00324 OXNAD1 - Oxidoreductase NAD-binding domain-containing protein 1 precursor - Bos taurus (Bovine) - OXNAD1 gene Indicus|evm.model.CM009491.1.988 Q7SZI5 RFTN1_CHICK 56.250 0.372781 0.280731 RFTN1 - Raftlin - Gallus gallus (Chicken) - RFTN1 gene May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling. Indicus|evm.model.CM009491.1.989 Q14699 RFTN1_HUMAN 90.769 0.503937 0.219723 RFTN1 - Raftlin - Homo sapiens (Human) - RFTN1 gene Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). Indicus|evm.model.CM009491.1.991 Q14699 RFTN1_HUMAN 95.238 0.356522 0.198962 RFTN1 - Raftlin - Homo sapiens (Human) - RFTN1 gene Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). Indicus|evm.model.CM009491.1.992 Q9Y2I1 NISCH_HUMAN 47.273 0.480226 0.117686 NISCH - Nischarin - Homo sapiens (Human) - NISCH gene Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures. Indicus|evm.model.CM009491.1.993 Q64368 DAZL_MOUSE 93.515 0.924051 1.0604 Dazl - Deleted in azoospermia-like - Mus musculus (Mouse) - Dazl gene RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts. Indicus|evm.model.CM009491.1.995 Q9UPR0 PLCL2_HUMAN 97.303 0.998004 0.889086 PLCL2 - Inactive phospholipase C-like protein 2 - Homo sapiens (Human) - PLCL2 gene May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. Indicus|evm.model.CM009491.1.996 Q92609 TBCD5_HUMAN 92.160 0.945148 0.89434 TBC1D5 - TBC1 domain family member 5 - Homo sapiens (Human) - TBC1D5 gene May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). Indicus|evm.model.CM009491.1.1003 Q96L42 KCNH8_HUMAN 88.298 0.7 0.117435 KCNH8 - Potassium voltage-gated channel subfamily H member 8 - Homo sapiens (Human) - KCNH8 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Indicus|evm.model.CM009491.1.1004 Q16778 H2B2E_HUMAN 85.714 0.984252 1.00794 H2BC21 - Histone H2B type 2-E - Homo sapiens (Human) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009492.1.4 O95221 OR5F1_HUMAN 59.091 0.923913 0.585987 OR5F1 - Olfactory receptor 5F1 - Homo sapiens (Human) - OR5F1 gene Odorant receptor. Indicus|evm.model.CM009492.1.5 Q1ZZS1 LGSN_CANLF 87.121 0.996219 0.921603 LGSN - Lengsin - Canis lupus familiaris (Dog) - LGSN gene May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity). Indicus|evm.model.CM009492.1.6 P83917 CBX1_MOUSE 96.757 0.989247 1.00541 Cbx1 - Chromobox protein homolog 1 - Mus musculus (Mouse) - Cbx1 gene Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Indicus|evm.model.CM009492.1.7 Q04671 P_HUMAN 88.372 0.0684039 0.732697 OCA2 - P protein - Homo sapiens (Human) - OCA2 gene Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Indicus|evm.model.CM009492.1.8 O95714 HERC2_HUMAN 95.886 0.999587 1.00083 HERC2 - E3 ubiquitin-protein ligase HERC2 - Homo sapiens (Human) - HERC2 gene E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Indicus|evm.model.CM009492.1.9 Q8BHK1 NIPA1_MOUSE 98.765 0.993846 1.00619 Nipa1 - Magnesium transporter NIPA1 - Mus musculus (Mouse) - Nipa1 gene Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+). Indicus|evm.model.CM009492.1.10 Q3SWX0 NIPA2_BOVIN 100.000 0.99446 1.00278 NIPA2 - Magnesium transporter NIPA2 - Bos taurus (Bovine) - NIPA2 gene Acts as a selective Mg(2+) transporter. Indicus|evm.model.CM009492.1.11 Q7TMB8 CYFP1_MOUSE 99.042 0.998405 1.0008 Cyfip1 - Cytoplasmic FMR1-interacting protein 1 - Mus musculus (Mouse) - Cyfip1 gene Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). Indicus|evm.model.CM009492.1.12 Q95K09 GCP5_MACFA 93.931 0.706341 1.41379 TUBGCP5 - Gamma-tubulin complex component 5 - Macaca fascicularis (Crab-eating macaque) - TUBGCP5 gene Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Indicus|evm.model.CM009492.1.13 Q3SZB5 CC115_BOVIN 99.444 0.98895 1.00556 CCDC115 - Coiled-coil domain-containing protein 115 - Bos taurus (Bovine) - CCDC115 gene Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity). Indicus|evm.model.CM009492.1.14 Q0VD01 IMP4_BOVIN 100.000 0.993151 1.00344 IMP4 - U3 small nucleolar ribonucleoprotein protein IMP4 - Bos taurus (Bovine) - IMP4 gene Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). Indicus|evm.model.CM009492.1.15 Q99952 PTN18_HUMAN 79.565 0.995604 0.98913 PTPN18 - Tyrosine-protein phosphatase non-receptor type 18 - Homo sapiens (Human) - PTPN18 gene Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. Indicus|evm.model.CM009492.1.17 Q8N944 AMER3_HUMAN 68.143 0.996287 0.938444 AMER3 - APC membrane recruitment protein 3 - Homo sapiens (Human) - AMER3 gene Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). Indicus|evm.model.CM009492.1.18 Q7TNR9 ARHG4_MOUSE 89.876 0.250649 3.9814 Arhgef4 - Rho guanine nucleotide exchange factor 4 - Mus musculus (Mouse) - Arhgef4 gene Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Indicus|evm.model.CM009492.1.19 Q0IHC4 F168B_XENLA 88.194 0.85119 0.746667 fam168b - Myelin-associated neurite-outgrowth inhibitor - Xenopus laevis (African clawed frog) - fam168b gene Inhibitor of neuronal axonal outgrowth. Indicus|evm.model.CM009492.1.20 Q5R4K6 PKHB2_PONAB 94.595 0.991031 1.0045 PLEKHB2 - Pleckstrin homology domain-containing family B member 2 - Pongo abelii (Sumatran orangutan) - PLEKHB2 gene Involved in retrograde transport of recycling endosomes. Indicus|evm.model.CM009492.1.21 P59999 ARPC4_MOUSE 55.689 0.976923 0.77381 Arpc4 - Actin-related protein 2/3 complex subunit 4 - Mus musculus (Mouse) - Arpc4 gene Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Indicus|evm.model.CM009492.1.22 Q4R4Z6 RS3A_MACFA 66.176 0.982759 0.439394 RPS3A - 40S ribosomal protein S3a - Macaca fascicularis (Crab-eating macaque) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009492.1.23 P61246 RS3A_FELCA 81.429 0.971831 0.273077 RPS3A - 40S ribosomal protein S3a - Felis catus (Cat) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009492.1.26 O60243 H6ST1_HUMAN 96.509 0.995025 0.978102 HS6ST1 - Heparan-sulfate 6-O-sulfotransferase 1 - Homo sapiens (Human) - HS6ST1 gene 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. Indicus|evm.model.CM009492.1.27 Q9NYU2 UGGG1_HUMAN 93.963 0.99871 0.996785 UGGT1 - UDP-glucose:glycoprotein glucosyltransferase 1 precursor - Homo sapiens (Human) - UGGT1 gene Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Indicus|evm.model.CM009492.1.28 Q9H0E3 SP130_HUMAN 94.134 0.99811 1.00954 SAP130 - Histone deacetylase complex subunit SAP130 - Homo sapiens (Human) - SAP130 gene Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Indicus|evm.model.CM009492.1.29 Q5RDQ3 AMERL_PONAB 99.677 0.993569 1.00323 AMMECR1L - AMMECR1-like protein - Pongo abelii (Sumatran orangutan) - AMMECR1L gene Indicus|evm.model.CM009492.1.30 Q9D7M8 RPB4_MOUSE 99.296 0.986014 1.00704 Polr2d - DNA-directed RNA polymerase II subunit RPB4 - Mus musculus (Mouse) - Polr2d gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Indicus|evm.model.CM009492.1.31 Q8N9M1 CS047_HUMAN 84.000 0.569767 0.203791 C19orf47 - Uncharacterized protein C19orf47 - Homo sapiens (Human) - C19orf47 gene nucleoplasm, nucleus Indicus|evm.model.CM009492.1.32 Q9C0J8 WDR33_HUMAN 98.129 0.998504 1.00075 WDR33 - pre-mRNA 3' end processing protein WDR33 - Homo sapiens (Human) - WDR33 gene Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. Indicus|evm.model.CM009492.1.33 Q587I9 SFT2C_HUMAN 80.000 0.990654 0.995349 SFT2D3 - Vesicle transport protein SFT2C - Homo sapiens (Human) - SFT2D3 gene May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Indicus|evm.model.CM009492.1.34 Q2KJ33 LIMS2_BOVIN 99.650 0.630531 1.32551 LIMS2 - LIM and senescent cell antigen-like-containing domain protein 2 - Bos taurus (Bovine) - LIMS2 gene Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Indicus|evm.model.CM009492.1.35 Q6PIF6 MYO7B_HUMAN 83.007 0.996283 1.01701 MYO7B - Unconventional myosin-VIIb - Homo sapiens (Human) - MYO7B gene Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable). Indicus|evm.model.CM009492.1.36 Q96ST2 IWS1_HUMAN 86.305 0.997642 1.03541 IWS1 - Protein IWS1 homolog - Homo sapiens (Human) - IWS1 gene Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. Indicus|evm.model.CM009492.1.37 Q99K70 RRAGC_MOUSE 98.498 0.994012 0.839196 Rragc - Ras-related GTP-binding protein C - Mus musculus (Mouse) - Rragc gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Indicus|evm.model.CM009492.1.38 P00745 PROC_BOVIN 99.780 0.859848 1.15789 PROC - Vitamin K-dependent protein C precursor - Bos taurus (Bovine) - PROC gene Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Indicus|evm.model.CM009492.1.39 Q9Y2U5 M3K2_HUMAN 97.738 0.995169 1.00323 MAP3K2 - Mitogen-activated protein kinase kinase kinase 2 - Homo sapiens (Human) - MAP3K2 gene Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. Indicus|evm.model.CM009492.1.40 Q1RMT1 ERCC3_BOVIN 100.000 0.997446 1.00128 ERCC3 - General transcription and DNA repair factor IIH helicase subunit XPB - Bos taurus (Bovine) - ERCC3 gene ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Indicus|evm.model.CM009492.1.41 Q4G0S4 C27C1_HUMAN 85.772 0.978389 0.939114 CYP27C1 - Cytochrome P450 27C1 precursor - Homo sapiens (Human) - CYP27C1 gene A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Indicus|evm.model.CM009492.1.42 Q58DQ3 RL6_BOVIN 96.078 0.452915 0.777003 RPL6 - 60S ribosomal protein L6 - Bos taurus (Bovine) - RPL6 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009492.1.43 C0HKE9 H2A1P_MOUSE 97.692 0.68617 1.44615 Hist1h2ap - Histone H2A type 1-P - Mus musculus (Mouse) - Hist1h2ap gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009492.1.44 O00499 BIN1_HUMAN 91.400 0.994614 0.939292 BIN1 - Myc box-dependent-interacting protein 1 - Homo sapiens (Human) - BIN1 gene Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). Indicus|evm.model.CM009492.1.46 Q13506 NAB1_HUMAN 95.893 0.687412 1.45175 NAB1 - NGFI-A-binding protein 1 - Homo sapiens (Human) - NAB1 gene Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Indicus|evm.model.CM009492.1.47 A6NFY4 NEMP2_HUMAN 66.227 0.882629 1.02158 NEMP2 - Nuclear envelope integral membrane protein 2 precursor - Homo sapiens (Human) - NEMP2 gene nuclear envelope Indicus|evm.model.CM009492.1.48 A1DWM3 MFSD6_PIG 90.274 0.9975 1.00251 MFSD6 - Major facilitator superfamily domain-containing protein 6 - Sus scrofa (Pig) - MFSD6 gene membrane, plasma membrane, antigen processing and presentation of exogenous peptide antigen via MHC class I Indicus|evm.model.CM009492.1.49 P21327 INPP_BOVIN 100.000 0.995012 1.0025 INPP1 - Inositol polyphosphate 1-phosphatase - Bos taurus (Bovine) - INPP1 gene inositol-1,4-bisphosphate 1-phosphatase activity, inositol phosphate dephosphorylation Indicus|evm.model.CM009492.1.51 Q2HJ73 HIBCH_BOVIN 99.682 0.963077 0.841969 HIBCH - 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor - Bos taurus (Bovine) - HIBCH gene Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). Indicus|evm.model.CM009492.1.52 O18836 GDF8_BOVIN 100.000 0.994681 1.00267 MSTN - Growth/differentiation factor 8 precursor - Bos taurus (Bovine) - MSTN gene Acts specifically as a negative regulator of skeletal muscle growth. Indicus|evm.model.CM009492.1.54 P54277 PMS1_HUMAN 83.387 0.997856 1.00107 PMS1 - PMS1 protein homolog 1 - Homo sapiens (Human) - PMS1 gene Probably involved in the repair of mismatches in DNA. Indicus|evm.model.CM009492.1.55 Q29RQ9 ORML1_BOVIN 100.000 0.987013 1.00654 ORMDL1 - ORM1-like protein 1 - Bos taurus (Bovine) - ORMDL1 gene Negative regulator of sphingolipid synthesis. Indicus|evm.model.CM009492.1.56 Q9H4B0 OSGP2_HUMAN 88.406 0.995181 1.00242 OSGEPL1 - Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial precursor - Homo sapiens (Human) - OSGEPL1 gene Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. Indicus|evm.model.CM009492.1.57 Q7Z5J8 ANKAR_HUMAN 88.243 0.998617 1.00837 ANKAR - Ankyrin and armadillo repeat-containing protein - Homo sapiens (Human) - ANKAR gene Indicus|evm.model.CM009492.1.58 Q0V8E4 ASND1_BOVIN 99.219 0.99688 1.00156 ASNSD1 - Asparagine synthetase domain-containing protein 1 - Bos taurus (Bovine) - ASNSD1 gene Indicus|evm.model.CM009492.1.59 L0R819 ASURF_HUMAN 82.292 0.979381 1.01042 ASDURF - ASNSD1 upstream open reading frame protein - Homo sapiens (Human) - ASDURF gene Indicus|evm.model.CM009492.1.60 Q9NP59 S40A1_HUMAN 89.913 0.996522 1.00701 SLC40A1 - Solute carrier family 40 member 1 - Homo sapiens (Human) - SLC40A1 gene May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Indicus|evm.model.CM009492.1.61 Q8IWA0 WDR75_HUMAN 91.456 0.997596 1.00241 WDR75 - WD repeat-containing protein 75 - Homo sapiens (Human) - WDR75 gene Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Indicus|evm.model.CM009492.1.62 P05997 CO5A2_HUMAN 88.843 0.965714 0.933956 COL5A2 - Collagen alpha-2(V) chain precursor - Homo sapiens (Human) - COL5A2 gene Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). Indicus|evm.model.CM009492.1.63 P02461 CO3A1_HUMAN 76.583 0.998446 0.877899 COL3A1 - Collagen alpha-1(III) chain precursor - Homo sapiens (Human) - COL3A1 gene Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. Indicus|evm.model.CM009492.1.65 Q9UBP9 GULP1_HUMAN 96.711 0.993443 1.00329 GULP1 - PTB domain-containing engulfment adapter protein 1 - Homo sapiens (Human) - GULP1 gene May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. Indicus|evm.model.CM009492.1.66 P10646 TFPI1_HUMAN 69.103 0.986622 0.983553 TFPI - Tissue factor pathway inhibitor precursor - Homo sapiens (Human) - TFPI gene Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. Indicus|evm.model.CM009492.1.67 A6QP74 CALRL_BOVIN 93.737 0.993304 0.969697 CALCRL - Calcitonin gene-related peptide type 1 receptor precursor - Bos taurus (Bovine) - CALCRL gene Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Indicus|evm.model.CM009492.1.68 Q8NEG5 ZSWM2_HUMAN 76.378 0.823147 1.21485 ZSWIM2 - E3 ubiquitin-protein ligase ZSWIM2 - Homo sapiens (Human) - ZSWIM2 gene E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes. Indicus|evm.model.CM009492.1.69 Q6P995 F171B_HUMAN 92.380 0.97903 0.923729 FAM171B - Protein FAM171B precursor - Homo sapiens (Human) - FAM171B gene Indicus|evm.model.CM009492.1.70 P80746 ITAV_BOVIN 99.771 0.891837 0.935115 ITGAV - Integrin alpha-V precursor - Bos taurus (Bovine) - ITGAV gene The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (By similarity). Indicus|evm.model.CM009492.1.71 Q1RMM1 ZC3HF_BOVIN 100.000 0.995316 1.00235 ZC3H15 - Zinc finger CCCH domain-containing protein 15 - Bos taurus (Bovine) - ZC3H15 gene Protects DRG1 from proteolytic degradation. Indicus|evm.model.CM009492.1.73 Q5CZC0 FSIP2_HUMAN 67.024 0.999708 0.991024 FSIP2 - Fibrous sheath-interacting protein 2 - Homo sapiens (Human) - FSIP2 gene Plays a role in spermatogenesis. Indicus|evm.model.CM009492.1.74 Q9MYN5 CDKN3_PIG 50.000 0.978723 0.443396 CDKN3 - Cyclin-dependent kinase inhibitor 3 - Sus scrofa (Pig) - CDKN3 gene May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity). Indicus|evm.model.CM009492.1.75 Q9NX94 WBP1L_HUMAN 73.684 0.935593 0.862573 WBP1L - WW domain binding protein 1-like - Homo sapiens (Human) - WBP1L gene Indicus|evm.model.CM009492.1.76 Q7Z570 Z804A_HUMAN 78.620 0.998295 0.970223 ZNF804A - Zinc finger protein 804A - Homo sapiens (Human) - ZNF804A gene cytoplasm, dendritic microtubule, dendritic shaft, dendritic spine, growth cone, neuronal cell body, nucleus, plasma membrane, postsynapse, positive regulation of gene expression Indicus|evm.model.CM009492.1.77 Q63486 RRAGA_RAT 97.125 0.993631 1.00319 Rraga - Ras-related GTP-binding protein A - Rattus norvegicus (Rat) - Rraga gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Indicus|evm.model.CM009492.1.78 Q5R946 PIGP_PONAB 86.719 0.907143 1.04478 PIGP - Phosphatidylinositol N-acetylglucosaminyltransferase subunit P - Pongo abelii (Sumatran orangutan) - PIGP gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Indicus|evm.model.CM009492.1.79 Q8NFH5 NUP35_HUMAN 96.330 0.993902 1.00613 NUP35 - Nucleoporin NUP35 - Homo sapiens (Human) - NUP35 gene Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. Indicus|evm.model.CM009492.1.80 Q8WTR2 DUS19_HUMAN 91.589 0.934211 1.05069 DUSP19 - Dual specificity protein phosphatase 19 - Homo sapiens (Human) - DUSP19 gene Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Indicus|evm.model.CM009492.1.81 Q9Y2A7 NCKP1_HUMAN 96.196 0.983486 0.966312 NCKAP1 - Nck-associated protein 1 - Homo sapiens (Human) - NCKAP1 gene Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. Indicus|evm.model.CM009492.1.82 Q95117 SFRP3_BOVIN 95.077 0.993548 0.953846 FRZB - Secreted frizzled-related protein 3 precursor - Bos taurus (Bovine) - FRZB gene Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Indicus|evm.model.CM009492.1.83 Q8IXB1 DJC10_HUMAN 91.677 0.997481 1.00126 DNAJC10 - DnaJ homolog subfamily C member 10 precursor - Homo sapiens (Human) - DNAJC10 gene Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. Indicus|evm.model.CM009492.1.84 P14100 PDE1A_BOVIN 98.812 0.978641 0.971698 PDE1A - Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A - Bos taurus (Bovine) - PDE1A gene Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP (By similarity). Indicus|evm.model.CM009492.1.85 P28290 ITPI2_HUMAN 86.032 0.998413 1.00079 ITPRID2 - Protein ITPRID2 - Homo sapiens (Human) - ITPRID2 gene cytosol, nucleoplasm, plasma membrane, actin filament binding Indicus|evm.model.CM009492.1.87 Q13562 NDF1_HUMAN 98.034 0.994398 1.00281 NEUROD1 - Neurogenic differentiation factor 1 - Homo sapiens (Human) - NEUROD1 gene Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). Indicus|evm.model.CM009492.1.88 Q49MI3 CERKL_HUMAN 81.688 0.97786 0.971326 CERKL - Ceramide kinase-like protein - Homo sapiens (Human) - CERKL gene Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. Indicus|evm.model.CM009492.1.89 P13612 ITA4_HUMAN 85.659 0.997099 1.00194 ITGA4 - Integrin alpha-4 precursor - Homo sapiens (Human) - ITGA4 gene Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). Indicus|evm.model.CM009492.1.91 P52483 UB2E3_MOUSE 100.000 0.990385 1.00483 Ube2e3 - Ubiquitin-conjugating enzyme E2 E3 - Mus musculus (Mouse) - Ube2e3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination (By similarity). Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. Indicus|evm.model.CM009492.1.92 O77737 B2CL1_PIG 71.533 0.900662 0.648069 BCL2L1 - Bcl-2-like protein 1 - Sus scrofa (Pig) - BCL2L1 gene Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). Indicus|evm.model.CM009492.1.95 Q9HCG8 CWC22_HUMAN 90.308 0.99667 0.992291 CWC22 - Pre-mRNA-splicing factor CWC22 homolog - Homo sapiens (Human) - CWC22 gene Required for pre-mRNA splicing as component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Indicus|evm.model.CM009492.1.96 Q569K4 Z385B_HUMAN 97.059 0.468531 0.303609 ZNF385B - Zinc finger protein 385B - Homo sapiens (Human) - ZNF385B gene May play a role in p53/TP53-mediated apoptosis. Indicus|evm.model.CM009492.1.97 B2KI64 PI4KB_RHIFE 90.909 0.98 0.122549 PI4KB - Phosphatidylinositol 4-kinase beta - Rhinolophus ferrumequinum (Greater horseshoe bat) - PI4KB gene Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). Indicus|evm.model.CM009492.1.98 A9X1A0 PI4KB_PAPAN 74.090 0.963504 0.503676 PI4KB - Phosphatidylinositol 4-kinase beta - Papio anubis (Olive baboon) - PI4KB gene Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). Indicus|evm.model.CM009492.1.99 Q569K4 Z385B_HUMAN 95.584 0.941176 0.866242 ZNF385B - Zinc finger protein 385B - Homo sapiens (Human) - ZNF385B gene May play a role in p53/TP53-mediated apoptosis. Indicus|evm.model.CM009492.1.100 Q86VW0 SESD1_HUMAN 98.547 0.992771 0.596264 SESTD1 - SEC14 domain and spectrin repeat-containing protein 1 - Homo sapiens (Human) - SESTD1 gene May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. Indicus|evm.model.CM009492.1.101 Q6ZP82 CC141_HUMAN 80.042 0.935673 1.06138 CCDC141 - Coiled-coil domain-containing protein 141 - Homo sapiens (Human) - CCDC141 gene Plays a critical role in radial migration and centrosomal function. Indicus|evm.model.CM009492.1.102 Q8WZ42 TITIN_HUMAN 94.132 0.660534 0.995226 TTN - Titin - Homo sapiens (Human) - TTN gene Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. Indicus|evm.model.CM009492.1.103 Q9HB20 PKHA3_HUMAN 95.333 0.993355 1.00333 PLEKHA3 - Pleckstrin homology domain-containing family A member 3 - Homo sapiens (Human) - PLEKHA3 gene Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). Indicus|evm.model.CM009492.1.105 Q9Y680 FKBP7_HUMAN 89.450 0.990868 0.986486 FKBP7 - Peptidyl-prolyl cis-trans isomerase FKBP7 precursor - Homo sapiens (Human) - FKBP7 gene PPIases accelerate the folding of proteins during protein synthesis. Indicus|evm.model.CM009492.1.106 Q0ZLH3 PJVK_HUMAN 98.864 0.994334 1.00284 PJVK - Pejvakin - Homo sapiens (Human) - PJVK gene Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation. Indicus|evm.model.CM009492.1.107 Q2HJ92 PRKRA_BOVIN 100.000 0.993631 1.00319 PRKRA - Interferon-inducible double-stranded RNA-dependent protein kinase activator A - Bos taurus (Bovine) - PRKRA gene Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). Indicus|evm.model.CM009492.1.108 Q8BXR9 OSBL6_MOUSE 97.393 0.997917 1.00104 Osbpl6 - Oxysterol-binding protein-related protein 6 - Mus musculus (Mouse) - Osbpl6 gene Regulates cellular transport and efflux of cholesterol (By similarity). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (PubMed:30028970). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (PubMed:30028970). Weakly binds 25-hydroxycholesterol (By similarity). Indicus|evm.model.CM009492.1.109 Q8IUH3 RBM45_HUMAN 95.588 0.995789 0.997899 RBM45 - RNA-binding protein 45 - Homo sapiens (Human) - RBM45 gene RNA-binding protein with binding specificity for poly(C). May play an important role in neural development. Indicus|evm.model.CM009492.1.110 Q3SZT9 CYC2_BOVIN 100.000 0.981132 1.00952 CYCT - Cytochrome c 2 - Bos taurus (Bovine) - CYCT gene Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). Indicus|evm.model.CM009492.1.111 Q9HCR9 PDE11_HUMAN 87.171 0.907692 0.348339 PDE11A - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Homo sapiens (Human) - PDE11A gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. Indicus|evm.model.CM009492.1.112 Q5R893 H2B1_PONAB 92.537 0.970588 0.539683 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009492.1.113 Q9HCR9 PDE11_HUMAN 100.000 0.392593 0.144695 PDE11A - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Homo sapiens (Human) - PDE11A gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. Indicus|evm.model.CM009492.1.114 Q8VID6 PDE11_RAT 100.000 0.855556 0.0962567 Pde11a - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Rattus norvegicus (Rat) - Pde11a gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity). Indicus|evm.model.CM009492.1.115 Q9HCR9 PDE11_HUMAN 85.915 0.597458 0.252947 PDE11A - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Homo sapiens (Human) - PDE11A gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. Indicus|evm.model.CM009492.1.116 Q9HCR9 PDE11_HUMAN 92.806 0.871069 0.340836 PDE11A - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Homo sapiens (Human) - PDE11A gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. Indicus|evm.model.CM009492.1.117 P83863 H2B_PENVA 91.304 0.608108 0.637931 Histone H2B - Penaeus vannamei (Whiteleg shrimp) Indicus|evm.model.CM009492.1.118 A2VE45 TT30A_BOVIN 100.000 0.996992 1.00151 TTC30A - Tetratricopeptide repeat protein 30A - Bos taurus (Bovine) - TTC30A gene Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Indicus|evm.model.CM009492.1.119 A6H739 TT30B_BOVIN 99.849 0.996992 1.00151 TTC30B - Tetratricopeptide repeat protein 30B - Bos taurus (Bovine) - TTC30B gene Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Indicus|evm.model.CM009492.1.120 O00116 ADAS_HUMAN 94.391 0.907324 1.01672 AGPS - Alkyldihydroxyacetonephosphate synthase, peroxisomal precursor - Homo sapiens (Human) - AGPS gene Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. Indicus|evm.model.CM009492.1.121 Q78EG7 TP4A1_RAT 78.689 0.491525 0.682081 Ptp4a1 - Protein tyrosine phosphatase type IVA 1 precursor - Rattus norvegicus (Rat) - Ptp4a1 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). Indicus|evm.model.CM009492.1.122 Q5NUA6 NF2L2_BOVIN 99.671 0.996711 1.00165 NFE2L2 - Nuclear factor erythroid 2-related factor 2 - Bos taurus (Bovine) - NFE2L2 gene Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles. In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes. The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity). Indicus|evm.model.CM009492.1.123 Q6URK4 ROA3_RAT 99.474 0.994737 1.00264 Hnrnpa3 - Heterogeneous nuclear ribonucleoprotein A3 - Rattus norvegicus (Rat) - Hnrnpa3 gene Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. Indicus|evm.model.CM009492.1.125 Q2L969 MTX2_PIG 97.004 0.992453 0.992509 MTX2 - Metaxin-2 - Sus scrofa (Pig) - MTX2 gene Involved in transport of proteins into the mitochondrion. Indicus|evm.model.CM009492.1.126 Q9GZZ0 HXD1_HUMAN 80.488 0.993808 0.984756 HOXD1 - Homeobox protein Hox-D1 - Homo sapiens (Human) - HOXD1 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Indicus|evm.model.CM009492.1.127 P31249 HXD3_HUMAN 96.313 0.995402 1.00694 HOXD3 - Homeobox protein Hox-D3 - Homo sapiens (Human) - HOXD3 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009492.1.128 A2T6X6 HXD4_PANTR 93.023 0.992278 1.01569 HOXD4 - Homeobox protein Hox-D4 - Pan troglodytes (Chimpanzee) - HOXD4 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009492.1.129 P13378 HXD8_HUMAN 89.041 0.992806 0.958621 HOXD8 - Homeobox protein Hox-D8 - Homo sapiens (Human) - HOXD8 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009492.1.130 P28357 HXD9_MOUSE 87.791 0.994203 1.0177 Hoxd9 - Homeobox protein Hox-D9 - Mus musculus (Mouse) - Hoxd9 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009492.1.131 P28358 HXD10_HUMAN 99.412 0.994135 1.00294 HOXD10 - Homeobox protein Hox-D10 - Homo sapiens (Human) - HOXD10 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009492.1.132 P23813 HXD11_MOUSE 100.000 0.197248 0.674923 Hoxd11 - Homeobox protein Hox-D11 - Mus musculus (Mouse) - Hoxd11 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009492.1.133 Q5EU40 HXD12_CARPS 91.852 0.867314 1.14444 HOXD12 - Homeobox protein Hox-D12 - Carollia perspicillata (Seba's short-tailed bat) - HOXD12 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009492.1.134 Q5EU41 HXD13_CARPS 97.942 0.460952 1.57658 HOXD13 - Homeobox protein Hox-D13 - Carollia perspicillata (Seba's short-tailed bat) - HOXD13 gene Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009492.1.135 P62268 RS23_RAT 90.909 0.983607 0.853147 Rps23 - 40S ribosomal protein S23 - Rattus norvegicus (Rat) - Rps23 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Indicus|evm.model.CM009492.1.136 Q9C0E8 LNP_HUMAN 79.439 0.992537 0.939252 LNPK - Endoplasmic reticulum junction formation protein lunapark - Homo sapiens (Human) - LNPK gene Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). Indicus|evm.model.CM009492.1.137 Q32L31 HMGB3_BOVIN 98.889 0.98895 0.905 HMGB3 - High mobility group protein B3 - Bos taurus (Bovine) - HMGB3 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). Indicus|evm.model.CM009492.1.138 Q3ZC75 AT5G3_BOVIN 99.291 0.985915 1.00709 ATP5MC3 - ATP synthase F(0) complex subunit C3, mitochondrial precursor - Bos taurus (Bovine) - ATP5MC3 gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. Indicus|evm.model.CM009492.1.139 P15336 ATF2_HUMAN 99.010 0.996047 1.00198 ATF2 - Cyclic AMP-dependent transcription factor ATF-2 - Homo sapiens (Human) - ATF2 gene Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. Indicus|evm.model.CM009492.1.140 Q17QN0 CHIN_BOVIN 99.639 0.6 1.37725 CHN1 - N-chimaerin - Bos taurus (Bovine) - CHN1 gene GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance (By similarity). Indicus|evm.model.CM009492.1.141 P02709 ACHA_BOVIN 100.000 0.995633 1.00219 CHRNA1 - Acetylcholine receptor subunit alpha precursor - Bos taurus (Bovine) - CHRNA1 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Indicus|evm.model.CM009492.1.143 O43516 WIPF1_HUMAN 86.250 0.791667 1.00199 WIPF1 - WAS/WASL-interacting protein family member 1 - Homo sapiens (Human) - WIPF1 gene Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. Indicus|evm.model.CM009492.1.144 Q7Z3F1 GP155_HUMAN 93.088 0.993103 1 GPR155 - Integral membrane protein GPR155 - Homo sapiens (Human) - GPR155 gene extracellular exosome, cognition Indicus|evm.model.CM009492.1.145 Q17QS0 SCRN3_BOVIN 100.000 0.995272 1.00237 SCRN3 - Secernin-3 - Bos taurus (Bovine) - SCRN3 gene Indicus|evm.model.CM009492.1.146 Q5U2T8 CIR1_RAT 98.707 0.587786 0.871397 Cir1 - Corepressor interacting with RBPJ 1 - Rattus norvegicus (Rat) - Cir1 gene May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). Indicus|evm.model.CM009492.1.147 P0CG40 SP9_HUMAN 99.356 0.99569 0.958678 SP9 - Transcription factor Sp9 - Homo sapiens (Human) - SP9 gene Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). Indicus|evm.model.CM009492.1.148 A8MUV8 ZN727_HUMAN 63.889 0.362245 0.392786 ZNF727 - Putative zinc finger protein 727 - Homo sapiens (Human) - ZNF727 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009492.1.149 Q2HJ33 OLA1_BOVIN 100.000 0.994962 1.00253 OLA1 - Obg-like ATPase 1 - Bos taurus (Bovine) - OLA1 gene Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. Indicus|evm.model.CM009492.1.151 Q02447 SP3_HUMAN 98.110 0.995652 0.883483 SP3 - Transcription factor Sp3 - Homo sapiens (Human) - SP3 gene Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. Indicus|evm.model.CM009492.1.153 Q791B0 UBL5_PSAOB 98.630 0.972973 1.0137 UBL5 - Ubiquitin-like protein 5 - Psammomys obesus (Fat sand rat) - UBL5 gene Indicus|evm.model.CM009492.1.154 O54838 DUS5_RAT 70.909 0.981481 0.28125 Dusp5 - Dual specificity protein phosphatase 5 - Rattus norvegicus (Rat) - Dusp5 gene Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. Indicus|evm.model.CM009492.1.155 Q32PH1 CDCA7_BOVIN 100.000 0.666667 1.29947 CDCA7 - Cell division cycle-associated protein 7 - Bos taurus (Bovine) - CDCA7 gene Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity). Indicus|evm.model.CM009492.1.156 Q9NYL2 M3K20_HUMAN 92.625 0.831426 1.20125 MAP3K20 - Mitogen-activated protein kinase kinase kinase 20 - Homo sapiens (Human) - MAP3K20 gene Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636). Indicus|evm.model.CM009492.1.157 Q8WZA2 RPGF4_HUMAN 94.877 0.998031 1.00495 RAPGEF4 - Rap guanine nucleotide exchange factor 4 - Homo sapiens (Human) - RAPGEF4 gene Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity). Indicus|evm.model.CM009492.1.158 Q15118 PDK1_HUMAN 94.064 0.995444 1.00688 PDK1 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial precursor - Homo sapiens (Human) - PDK1 gene Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. Indicus|evm.model.CM009492.1.159 Q61739 ITA6_MOUSE 91.751 0.998168 1.00092 Itga6 - Integrin alpha-6 precursor - Mus musculus (Mouse) - Itga6 gene Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (PubMed:8081870). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (PubMed:10634791). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (PubMed:8673141). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (By similarity). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). Indicus|evm.model.CM009492.1.161 Q07687 DLX2_HUMAN 93.413 0.993994 1.01524 DLX2 - Homeobox protein DLX-2 - Homo sapiens (Human) - DLX2 gene Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Indicus|evm.model.CM009492.1.162 P56177 DLX1_HUMAN 98.824 0.992188 1.00392 DLX1 - Homeobox protein DLX-1 - Homo sapiens (Human) - DLX1 gene Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity). Indicus|evm.model.CM009492.1.163 Q6UB28 MAP12_HUMAN 95.522 0.994048 1.00299 METAP1D - Methionine aminopeptidase 1D, mitochondrial precursor - Homo sapiens (Human) - METAP1D gene Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis. Indicus|evm.model.CM009492.1.164 O14929 HAT1_HUMAN 98.329 0.995238 1.00239 HAT1 - Histone acetyltransferase type B catalytic subunit - Homo sapiens (Human) - HAT1 gene Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:31278053, PubMed:20953179, PubMed:23653357, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:22615379, PubMed:11585814). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Acetylates also RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). Indicus|evm.model.CM009492.1.165 Q5RBC8 CMC1_PONAB 97.337 0.995562 0.99705 SLC25A12 - Calcium-binding mitochondrial carrier protein Aralar1 - Pongo abelii (Sumatran orangutan) - SLC25A12 gene Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. Indicus|evm.model.CM009492.1.166 Q0III3 DC1I2_BOVIN 99.826 0.987952 0.949346 DYNC1I2 - Cytoplasmic dynein 1 intermediate chain 2 - Bos taurus (Bovine) - DYNC1I2 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. Indicus|evm.model.CM009492.1.167 P62856 RS26_RAT 93.939 0.98 0.869565 Rps26 - 40S ribosomal protein S26 - Rattus norvegicus (Rat) - Rps26 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, mRNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009492.1.168 P70202 LXN_MOUSE 84.071 0.982456 0.513514 Lxn - Latexin - Mus musculus (Mouse) - Lxn gene Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4 (By similarity). May play a role in inflammation. Indicus|evm.model.CM009492.1.169 Q53TN4 CYBR1_HUMAN 81.818 0.993007 1 CYBRD1 - Plasma membrane ascorbate-dependent reductase CYBRD1 - Homo sapiens (Human) - CYBRD1 gene Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:30272000). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:30272000). It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337). May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity). Indicus|evm.model.CM009492.1.170 Q5H9S7 DCA17_HUMAN 86.680 0.975 1 DCAF17 - DDB1- and CUL4-associated factor 17 - Homo sapiens (Human) - DCAF17 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Indicus|evm.model.CM009492.1.171 Q9H825 METL8_HUMAN 80.861 0.604651 1.18213 METTL8 - mRNA N(3)-methylcytidine methyltransferase METTL8 - Homo sapiens (Human) - METTL8 gene S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs. Indicus|evm.model.CM009492.1.172 Q9UKI8 TLK1_HUMAN 99.347 0.997392 1.00131 TLK1 - Serine/threonine-protein kinase tousled-like 1 - Homo sapiens (Human) - TLK1 gene Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. Indicus|evm.model.CM009492.1.173 Q9H8Y8 GORS2_HUMAN 89.231 0.995614 1.00885 GORASP2 - Golgi reassembly-stacking protein 2 - Homo sapiens (Human) - GORASP2 gene Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). Indicus|evm.model.CM009492.1.174 Q0VCA1 DCE1_BOVIN 100.000 0.996639 1.00168 GAD1 - Glutamate decarboxylase 1 - Bos taurus (Bovine) - GAD1 gene Catalyzes the production of GABA. Indicus|evm.model.CM009492.1.175 A6QQ66 ERIC2_BOVIN 100.000 0.946309 1.0493 ERICH2 - Glutamate-rich protein 2 - Bos taurus (Bovine) - ERICH2 gene Indicus|evm.model.CM009492.1.176 Q6BEB4 SP5_HUMAN 87.186 0.994429 0.90201 SP5 - Transcription factor Sp5 - Homo sapiens (Human) - SP5 gene Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity). Indicus|evm.model.CM009492.1.177 Q8WXR4 MYO3B_HUMAN 88.919 0.961096 0.8434 MYO3B - Myosin-IIIb - Homo sapiens (Human) - MYO3B gene Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. Indicus|evm.model.CM009492.1.178 Q8WXR4 MYO3B_HUMAN 86.831 0.812081 0.222222 MYO3B - Myosin-IIIb - Homo sapiens (Human) - MYO3B gene Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. Indicus|evm.model.CM009492.1.179 Q6ZT12 UBR3_HUMAN 95.130 0.998918 0.979343 UBR3 - E3 ubiquitin-protein ligase UBR3 - Homo sapiens (Human) - UBR3 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610). Indicus|evm.model.CM009492.1.180 Q9NRN9 METL5_HUMAN 95.215 0.990476 1.00478 METTL5 - rRNA N6-adenosine-methyltransferase METTL5 - Homo sapiens (Human) - METTL5 gene Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:31328227, PubMed:32217665). N6-methylation of adenine(1832) in 18S rRNA is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (By similarity). Indicus|evm.model.CM009492.1.181 P10881 LA_BOVIN 100.000 0.995062 1.00248 SSB - Lupus La protein homolog - Bos taurus (Bovine) - SSB gene Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. Indicus|evm.model.CM009492.1.182 Q8NBE8 KLH23_HUMAN 98.387 0.996422 1.00179 KLHL23 - Kelch-like protein 23 - Homo sapiens (Human) - KLHL23 gene Indicus|evm.model.CM009492.1.183 Q2KI06 PHOP2_BOVIN 100.000 0.991736 1.00415 PHOSPHO2 - Pyridoxal phosphate phosphatase PHOSPHO2 - Bos taurus (Bovine) - PHOSPHO2 gene Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate (By similarity). Indicus|evm.model.CM009492.1.185 Q0VFZ6 CC173_HUMAN 87.386 0.99635 0.992754 CCDC173 - Coiled-coil domain-containing protein 173 - Homo sapiens (Human) - CCDC173 gene Indicus|evm.model.CM009492.1.186 Q13427 PPIG_HUMAN 94.562 0.997347 1 PPIG - Peptidyl-prolyl cis-trans isomerase G - Homo sapiens (Human) - PPIG gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. Indicus|evm.model.CM009492.1.187 Q53R41 FAKD1_HUMAN 75.962 0.997599 0.983471 FASTKD1 - FAST kinase domain-containing protein 1, mitochondrial precursor - Homo sapiens (Human) - FASTKD1 gene Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity. Indicus|evm.model.CM009492.1.188 O60662 KLH41_HUMAN 97.195 0.658324 1.5165 KLHL41 - Kelch-like protein 41 - Homo sapiens (Human) - KLHL41 gene Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. Indicus|evm.model.CM009492.1.190 C0HL13 LRP2_PIG 76.546 0.99957 0.99957 LRP2 - Low-density lipoprotein receptor-related protein 2 precursor - Sus scrofa (Pig) - LRP2 gene Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (By similarity). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (By similarity). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (PubMed:9228033). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity). Indicus|evm.model.CM009492.1.191 Q8HYR6 DHRS9_BOVIN 100.000 0.99375 1.00313 DHRS9 - Dehydrogenase/reductase SDR family member 9 precursor - Bos taurus (Bovine) - DHRS9 gene 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Plays also a role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH. Indicus|evm.model.CM009492.1.192 B8K1W2 ABCBB_CANLF 89.283 0.998492 1.00075 Abcb11e - Bile salt export pump - Canis lupus familiaris (Dog) - Abcb11e gene Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates to hepatic bile acids homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:18985798). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (By similarity). Indicus|evm.model.CM009492.1.193 Q9NQR9 G6PC2_HUMAN 89.802 0.988764 1.00282 G6PC2 - Glucose-6-phosphatase 2 - Homo sapiens (Human) - G6PC2 gene May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). Indicus|evm.model.CM009492.1.194 Q3ZBK3 SPC25_BOVIN 99.115 0.991189 1.00442 SPC25 - Kinetochore protein Spc25 - Bos taurus (Bovine) - SPC25 gene Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Indicus|evm.model.CM009492.1.195 Q2KJB5 NOSTN_BOVIN 99.605 0.996055 1.00396 NOSTRIN - Nostrin - Bos taurus (Bovine) - NOSTRIN gene Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. Indicus|evm.model.CM009492.1.196 Q6ZMG9 CERS6_HUMAN 91.582 0.994911 1.02344 CERS6 - Ceramide synthase 6 - Homo sapiens (Human) - CERS6 gene Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). Indicus|evm.model.CM009492.1.197 Q9UEW8 STK39_HUMAN 78.165 0.995763 0.866055 STK39 - STE20/SPS1-related proline-alanine-rich protein kinase - Homo sapiens (Human) - STK39 gene May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT. Indicus|evm.model.CM009492.1.198 Q9MYM7 B3GT1_PONPY 99.080 0.993884 1.00307 B3GALT1 - Beta-1,3-galactosyltransferase 1 - Pongo pygmaeus (Bornean orangutan) - B3GALT1 gene Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Indicus|evm.model.CM009492.1.200 A4UGR9 XIRP2_HUMAN 78.802 0.998792 0.981624 XIRP2 - Xin actin-binding repeat-containing protein 2 - Homo sapiens (Human) - XIRP2 gene Protects actin filaments from depolymerization. Indicus|evm.model.CM009492.1.203 Q01118 SCN7A_HUMAN 77.942 0.99881 0.999405 SCN7A - Sodium channel protein type 7 subunit alpha - Homo sapiens (Human) - SCN7A gene Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Indicus|evm.model.CM009492.1.204 Q32KL4 RMD1_BOVIN 97.391 0.987069 0.731861 RMDN1 - Regulator of microtubule dynamics protein 1 - Bos taurus (Bovine) - RMDN1 gene cytoplasm, mitotic spindle pole, spindle microtubule, microtubule binding Indicus|evm.model.CM009492.1.205 Q15858 SCN9A_HUMAN 93.587 0.998992 0.997988 SCN9A - Sodium channel protein type 9 subunit alpha - Homo sapiens (Human) - SCN9A gene Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784). Indicus|evm.model.CM009492.1.206 A2APX8 SCN1A_MOUSE 94.854 0.999 0.99552 Scn1a - Sodium channel protein type 1 subunit alpha - Mus musculus (Mouse) - Scn1a gene Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:16921370, PubMed:17928448, PubMed:27281198). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons (PubMed:16921370, PubMed:22914087). Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli (PubMed:27281198). Indicus|evm.model.CM009492.1.207 Q7Z4L5 TT21B_HUMAN 91.109 0.998481 1.00076 TTC21B - Tetratricopeptide repeat protein 21B - Homo sapiens (Human) - TTC21B gene Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs (PubMed:27932497). Negatively modulates the SHH signal transduction (By similarity). Indicus|evm.model.CM009492.1.209 Q14435 GALT3_HUMAN 95.735 0.996845 1.00158 GALNT3 - Polypeptide N-acetylgalactosaminyltransferase 3 - Homo sapiens (Human) - GALNT3 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis. Indicus|evm.model.CM009492.1.211 Q8WYN3 CSRN3_HUMAN 94.539 0.996587 1.00171 CSRNP3 - Cysteine/serine-rich nuclear protein 3 - Homo sapiens (Human) - CSRNP3 gene Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis (By similarity). Indicus|evm.model.CM009492.1.212 P79103 RS4_BOVIN 75.238 0.981132 0.403042 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009492.1.213 Q99250 SCN2A_HUMAN 96.974 0.999005 1.00299 SCN2A - Sodium channel protein type 2 subunit alpha - Homo sapiens (Human) - SCN2A gene Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). Indicus|evm.model.CM009492.1.214 Q9NY46 SCN3A_HUMAN 95.337 0.999005 1.005 SCN3A - Sodium channel protein type 3 subunit alpha - Homo sapiens (Human) - SCN3A gene Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:24157691, PubMed:28235671, PubMed:29466837). May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (By similarity). In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (By similarity). Indicus|evm.model.CM009492.1.216 Q53SF7 COBL1_HUMAN 71.596 0.998319 1.05496 COBLL1 - Cordon-bleu protein-like 1 - Homo sapiens (Human) - COBLL1 gene extracellular exosome, cadherin binding Indicus|evm.model.CM009492.1.217 Q5ICW4 GRB14_BOVIN 96.923 0.496124 0.238889 GRB14 - Growth factor receptor-bound protein 14 - Bos taurus (Bovine) - GRB14 gene Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity). Indicus|evm.model.CM009492.1.218 Q5ICW4 GRB14_BOVIN 98.851 0.955947 0.840741 GRB14 - Growth factor receptor-bound protein 14 - Bos taurus (Bovine) - GRB14 gene Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity). Indicus|evm.model.CM009492.1.219 Q5HY92 FIGN_HUMAN 96.667 0.997337 0.98946 FIGN - Fidgetin - Homo sapiens (Human) - FIGN gene ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Indicus|evm.model.CM009492.1.220 Q9NS40 KCNH7_HUMAN 99.029 0.87931 0.09699 KCNH7 - Potassium voltage-gated channel subfamily H member 7 - Homo sapiens (Human) - KCNH7 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Indicus|evm.model.CM009492.1.221 P63170 DYL1_RAT 85.393 0.977011 0.977528 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Indicus|evm.model.CM009492.1.222 Q9NS40 KCNH7_HUMAN 93.208 0.958942 0.916388 KCNH7 - Potassium voltage-gated channel subfamily H member 7 - Homo sapiens (Human) - KCNH7 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Indicus|evm.model.CM009492.1.223 Q5RAI6 GRAN_PONAB 75.229 0.772201 1.18807 GCA - Grancalcin - Pongo abelii (Sumatran orangutan) - GCA gene Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions (By similarity). Indicus|evm.model.CM009492.1.224 Q9BYX4 IFIH1_HUMAN 83.415 0.996086 0.997073 IFIH1 - Interferon-induced helicase C domain-containing protein 1 - Homo sapiens (Human) - IFIH1 gene Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Detects coronavirus SARS-CoV-2 (PubMed:33440148, PubMed:33514628). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. Indicus|evm.model.CM009492.1.225 A5D7B7 SEPR_BOVIN 100.000 0.97549 0.805263 FAP - Prolyl endopeptidase FAP - Bos taurus (Bovine) - FAP gene Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein. Also has dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner. Indicus|evm.model.CM009492.1.226 P01272 GLUC_BOVIN 100.000 0.90566 0.883333 GCG - Pro-glucagon precursor - Bos taurus (Bovine) - GCG gene Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Indicus|evm.model.CM009492.1.227 P81425 DPP4_BOVIN 100.000 0.948357 0.278431 DPP4 - Dipeptidyl peptidase 4 - Bos taurus (Bovine) - DPP4 gene Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Indicus|evm.model.CM009492.1.228 P81425 DPP4_BOVIN 99.686 0.960606 0.431373 DPP4 - Dipeptidyl peptidase 4 - Bos taurus (Bovine) - DPP4 gene Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Indicus|evm.model.CM009492.1.229 P81425 DPP4_BOVIN 78.182 0.987952 0.216993 DPP4 - Dipeptidyl peptidase 4 - Bos taurus (Bovine) - DPP4 gene Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Indicus|evm.model.CM009492.1.230 Q32LP4 S4A10_BOVIN 100.000 0.644489 0.901522 SLC4A10 - Sodium-driven chloride bicarbonate exchanger - Bos taurus (Bovine) - SLC4A10 gene Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (By similarity). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity). Indicus|evm.model.CM009492.1.231 Q16650 TBR1_HUMAN 99.560 0.997072 1.00147 TBR1 - T-box brain protein 1 - Homo sapiens (Human) - TBR1 gene Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:25232744, PubMed:30250039). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity). Indicus|evm.model.CM009492.1.232 O35593 PSDE_MOUSE 100.000 0.993569 1.00323 Psmd14 - 26S proteasome non-ATPase regulatory subunit 14 - Mus musculus (Mouse) - Psmd14 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. Indicus|evm.model.CM009492.1.234 Q58DT1 RL7_BOVIN 92.958 0.979167 0.580645 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Indicus|evm.model.CM009492.1.235 Q92844 TANK_HUMAN 87.529 0.995272 0.995294 TANK - TRAF family member-associated NF-kappa-B activator - Homo sapiens (Human) - TANK gene Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Indicus|evm.model.CM009492.1.236 Q3ZBP3 RBMS1_BOVIN 98.438 0.945679 1.00496 RBMS1 - RNA-binding motif, single-stranded-interacting protein 1 - Bos taurus (Bovine) - RBMS1 gene Single-stranded DNA binding protein that interacts with the region upstream of the C-myc gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication (By similarity). Indicus|evm.model.CM009492.1.237 Q8SQB8 ITB6_BOVIN 100.000 0.972806 1.02665 ITGB6 - Integrin beta-6 precursor - Bos taurus (Bovine) - ITGB6 gene Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). Indicus|evm.model.CM009492.1.238 P49259 PLA2R_BOVIN 99.932 0.998634 1.00068 PLA2R1 - Secretory phospholipase A2 receptor precursor - Bos taurus (Bovine) - PLA2R1 gene Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10. Indicus|evm.model.CM009492.1.239 O60449 LY75_HUMAN 80.093 0.99884 1.00116 LY75 - Lymphocyte antigen 75 precursor - Homo sapiens (Human) - LY75 gene Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. Indicus|evm.model.CM009492.1.240 A8WH74 CD302_BOVIN 100.000 0.991416 1.00431 CD302 - CD302 antigen precursor - Bos taurus (Bovine) - CD302 gene Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. Indicus|evm.model.CM009492.1.241 Q9H992 MARH7_HUMAN 86.441 0.997151 0.997159 MARCHF7 - E3 ubiquitin-protein ligase MARCHF7 - Homo sapiens (Human) - MARCHF7 gene E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Indicus|evm.model.CM009492.1.244 Q9UIF8 BAZ2B_HUMAN 91.376 0.230976 1.20018 BAZ2B - Bromodomain adjacent to zinc finger domain protein 2B - Homo sapiens (Human) - BAZ2B gene Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). Indicus|evm.model.CM009492.1.245 Q9C0D5 TANC1_HUMAN 88.788 0.99892 0.994627 TANC1 - Protein TANC1 - Homo sapiens (Human) - TANC1 gene May be a scaffold component in the postsynaptic density. Indicus|evm.model.CM009492.1.246 A2VEA7 DAPL1_BOVIN 100.000 0.549223 1.80374 DAPL1 - Death-associated protein-like 1 - Bos taurus (Bovine) - DAPL1 gene May play a role in the early stages of epithelial differentiation or in apoptosis. Indicus|evm.model.CM009492.1.247 Q99569 PKP4_HUMAN 97.634 0.998182 0.922819 PKP4 - Plakophilin-4 - Homo sapiens (Human) - PKP4 gene Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. Indicus|evm.model.CM009492.1.248 Q8NFR7 CC148_HUMAN 78.782 0.882456 0.964467 CCDC148 - Coiled-coil domain-containing protein 148 - Homo sapiens (Human) - CCDC148 gene Indicus|evm.model.CM009492.1.249 O95045 UPP2_HUMAN 89.274 0.984424 1.01262 UPP2 - Uridine phosphorylase 2 - Homo sapiens (Human) - UPP2 gene Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:12849978, PubMed:21855639). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable). Shows broad substrate specificity and accepts uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates (PubMed:12849978). Indicus|evm.model.CM009492.1.250 Q8NER5 ACV1C_HUMAN 97.644 0.994778 0.776876 ACVR1C - Activin receptor type-1C precursor - Homo sapiens (Human) - ACVR1C gene Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Indicus|evm.model.CM009492.1.251 O60759 CYTIP_HUMAN 84.444 0.994429 1 CYTIP - Cytohesin-interacting protein - Homo sapiens (Human) - CYTIP gene By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm. Indicus|evm.model.CM009492.1.252 Q3ZBR9 ERMIN_BOVIN 100.000 0.992933 1.00355 ERMN - Ermin - Bos taurus (Bovine) - ERMN gene Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). Indicus|evm.model.CM009492.1.253 Q7Z7M9 GALT5_HUMAN 80.937 0.996812 1.00106 GALNT5 - Polypeptide N-acetylgalactosaminyltransferase 5 - Homo sapiens (Human) - GALNT5 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity). Indicus|evm.model.CM009492.1.254 Q28041 ACVR1_BOVIN 99.804 0.996078 1.00196 ACVR1 - Activin receptor type-1 precursor - Bos taurus (Bovine) - ACVR1 gene Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A ors ACVR2B. Upon binding of ligands such as BMP7 or BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical signaling pathways. Indicus|evm.model.CM009492.1.257 A6QLU1 GPDM_BOVIN 100.000 0.997253 1.00138 GPD2 - Glycerol-3-phosphate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - GPD2 gene Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. Indicus|evm.model.CM009492.1.258 Q08E53 NR4A2_BOVIN 100.000 0.917051 1.08863 NR4A2 - Nuclear receptor subfamily 4 group A member 2 - Bos taurus (Bovine) - NR4A2 gene Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). Indicus|evm.model.CM009492.1.259 E1BNE9 KCNJ3_BOVIN 100.000 0.989744 0.389222 KCNJ3 - G protein-activated inward rectifier potassium channel 1 - Bos taurus (Bovine) - KCNJ3 gene This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. Indicus|evm.model.CM009492.1.260 E1BNE9 KCNJ3_BOVIN 99.675 0.993528 0.616766 KCNJ3 - G protein-activated inward rectifier potassium channel 1 - Bos taurus (Bovine) - KCNJ3 gene This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. Indicus|evm.model.CM009492.1.261 Q4U5R4 RN114_BOVIN 54.217 0.780952 0.456522 RNF114 - E3 ubiquitin-protein ligase RNF114 - Bos taurus (Bovine) - RNF114 gene E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. Indicus|evm.model.CM009492.1.262 Q8IUC8 GLT13_HUMAN 99.396 0.995984 0.895683 GALNT13 - Polypeptide N-acetylgalactosaminyltransferase 13 - Homo sapiens (Human) - GALNT13 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. May be responsible for the synthesis of Tn antigen in neuronal cells. Indicus|evm.model.CM009492.1.263 Q64519 SDC3_MOUSE 62.821 0.976378 0.28733 Sdc3 - Syndecan-3 precursor - Mus musculus (Mouse) - Sdc3 gene Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (By similarity). Indicus|evm.model.CM009492.1.264 Q1RMT2 RPRM_BOVIN 100.000 0.981818 1.00917 RPRM - Protein reprimo - Bos taurus (Bovine) - RPRM gene May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity). Indicus|evm.model.CM009492.1.266 Q56JZ1 RL13_BOVIN 90.047 0.990521 1 RPL13 - 60S ribosomal protein L13 - Bos taurus (Bovine) - RPL13 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development. Indicus|evm.model.CM009492.1.267 Q3MHM8 AR6P6_BOVIN 100.000 0.991189 1.00442 ARL6IP6 - ADP-ribosylation factor-like protein 6-interacting protein 6 - Bos taurus (Bovine) - ARL6IP6 gene nuclear inner membrane Indicus|evm.model.CM009492.1.268 O75400 PR40A_HUMAN 94.566 0.98172 0.971787 PRPF40A - Pre-mRNA-processing factor 40 homolog A - Homo sapiens (Human) - PRPF40A gene Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. Indicus|evm.model.CM009492.1.269 Q96PY5 FMNL2_HUMAN 92.096 0.980126 1.01934 FMNL2 - Formin-like protein 2 - Homo sapiens (Human) - FMNL2 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. Indicus|evm.model.CM009492.1.270 O75886 STAM2_HUMAN 92.593 0.937811 0.765714 STAM2 - Signal transducing adapter molecule 2 - Homo sapiens (Human) - STAM2 gene Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). Indicus|evm.model.CM009492.1.271 O00305 CACB4_HUMAN 99.575 0.991561 0.911538 CACNB4 - Voltage-dependent L-type calcium channel subunit beta-4 - Homo sapiens (Human) - CACNB4 gene The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Indicus|evm.model.CM009492.1.272 Q2KJ96 ARL5A_BOVIN 100.000 0.987879 0.921788 ARL5A - ADP-ribosylation factor-like protein 5A - Bos taurus (Bovine) - ARL5A gene Lacks ADP-ribosylation enhancing activity. Indicus|evm.model.CM009492.1.273 Q3B7M5 LASP1_BOVIN 76.562 0.00841234 28.8038 LASP1 - LIM and SH3 domain protein 1 - Bos taurus (Bovine) - LASP1 gene Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). Indicus|evm.model.CM009492.1.275 Q5UIP0 RIF1_HUMAN 79.363 0.999189 0.997573 RIF1 - Telomere-associated protein RIF1 - Homo sapiens (Human) - RIF1 gene Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). Indicus|evm.model.CM009492.1.276 P98066 TSG6_HUMAN 94.424 0.953737 1.01444 TNFAIP6 - Tumor necrosis factor-inducible gene 6 protein precursor - Homo sapiens (Human) - TNFAIP6 gene Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. Indicus|evm.model.CM009492.1.277 Q58DW5 RL5_BOVIN 86.538 0.901786 0.377104 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Indicus|evm.model.CM009492.1.278 Q4R5M0 RL5_MACFA 85.047 0.981481 0.363636 RPL5 - 60S ribosomal protein L5 - Macaca fascicularis (Crab-eating macaque) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Indicus|evm.model.CM009492.1.279 Q3ZCL3 NMI_BOVIN 98.706 0.76808 1.29773 NMI - N-myc-interactor - Bos taurus (Bovine) - NMI gene Acts as a signaling pathway regulator involved in innate immune system response. In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis. Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription. In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35. In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21. In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (By similarity). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion. Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines (By similarity). Indicus|evm.model.CM009492.1.280 Q6ZSC3 RBM43_HUMAN 63.764 0.991279 0.963585 RBM43 - RNA-binding protein 43 - Homo sapiens (Human) - RBM43 gene Indicus|evm.model.CM009492.1.281 Q6SA80 RND3_RAT 100.000 0.991837 1.0041 Rnd3 - Rho-related GTP-binding protein RhoE precursor - Rattus norvegicus (Rat) - Rnd3 gene Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Indicus|evm.model.CM009492.1.283 Q9R0Q3 TMED2_MOUSE 85.882 0.756757 0.552239 Tmed2 - Transmembrane emp24 domain-containing protein 2 precursor - Mus musculus (Mouse) - Tmed2 gene Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity). Required for morphogenesis of embryo and placenta. Indicus|evm.model.CM009492.1.284 Q9H3L0 MMAD_HUMAN 96.622 0.993266 1.00338 MMADHC - Cobalamin trafficking protein CblD precursor - Homo sapiens (Human) - MMADHC gene Involved in cobalamin metabolism and trafficking (PubMed:18385497, PubMed:23415655, PubMed:24722857, PubMed:26364851). Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl) (PubMed:18385497,PubMed:23415655, PubMed:24722857). Promotes oxidation of cob(II)alamin bound to MMACHC (PubMed:26364851). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510). Indicus|evm.model.CM009492.1.285 Q86Y78 LYPD6_HUMAN 71.930 0.984848 0.77193 LYPD6 - Ly6/PLAUR domain-containing protein 6 precursor - Homo sapiens (Human) - LYPD6 gene Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). Indicus|evm.model.CM009492.1.287 Q8NI32 LPD6B_HUMAN 92.308 0.988235 0.928962 LYPD6B - Ly6/PLAUR domain-containing protein 6B precursor - Homo sapiens (Human) - LYPD6B gene Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence. Indicus|evm.model.CM009492.1.288 O60282 KIF5C_HUMAN 98.746 0.997912 1.00104 KIF5C - Kinesin heavy chain isoform 5C - Homo sapiens (Human) - KIF5C gene Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Indicus|evm.model.CM009492.1.289 Q52LR7 EPC2_HUMAN 97.522 0.997525 1.00124 EPC2 - Enhancer of polycomb homolog 2 - Homo sapiens (Human) - EPC2 gene May play a role in transcription or DNA repair. Indicus|evm.model.CM009492.1.291 Q9P267 MBD5_HUMAN 97.083 0.552799 1.15997 MBD5 - Methyl-CpG-binding domain protein 5 - Homo sapiens (Human) - MBD5 gene Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro). Indicus|evm.model.CM009492.1.292 P01252 PTMA_BOVIN 95.455 0.981818 1 PTMA - Prothymosin alpha - Bos taurus (Bovine) - PTMA gene Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Indicus|evm.model.CM009492.1.294 Q2YDI2 ORC4_BOVIN 100.000 0.995423 1.00229 ORC4 - Origin recognition complex subunit 4 - Bos taurus (Bovine) - ORC4 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). Indicus|evm.model.CM009492.1.295 Q28043 AVR2A_BOVIN 100.000 0.996109 1.00195 ACVR2A - Activin receptor type-2A precursor - Bos taurus (Bovine) - ACVR2A gene On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. Indicus|evm.model.CM009492.1.299 P62315 SMD1_MOUSE 96.154 0.607143 0.705882 Snrpd1 - Small nuclear ribonucleoprotein Sm D1 - Mus musculus (Mouse) - Snrpd1 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. Indicus|evm.model.CM009492.1.300 Q6GQS1 SCMC3_MOUSE 73.571 0.985612 0.297645 Slc25a23 - Calcium-binding mitochondrial carrier protein SCaMC-3 - Mus musculus (Mouse) - Slc25a23 gene Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1. Indicus|evm.model.CM009492.1.301 O97725 NDUAC_BOVIN 99.000 0.961165 0.710345 NDUFA12 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 - Bos taurus (Bovine) - NDUFA12 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009492.1.302 Q5R613 SNX6_PONAB 95.305 0.990654 0.527094 SNX6 - Sorting nexin-6 - Pongo abelii (Sumatran orangutan) - SNX6 gene Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation. In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B. May contribute to transcription regulation (By similarity). Indicus|evm.model.CM009492.1.305 O60315 ZEB2_HUMAN 98.435 0.998354 1.00082 ZEB2 - Zinc finger E-box-binding homeobox 2 - Homo sapiens (Human) - ZEB2 gene Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). Indicus|evm.model.CM009492.1.306 Q08DA7 GTDC1_BOVIN 100.000 0.176991 1.23497 GTDC1 - Glycosyltransferase-like domain-containing protein 1 - Bos taurus (Bovine) - GTDC1 gene Indicus|evm.model.CM009492.1.309 A4IF90 RHG15_BOVIN 100.000 0.912791 0.36518 ARHGAP15 - Rho GTPase-activating protein 15 - Bos taurus (Bovine) - ARHGAP15 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity). Indicus|evm.model.CM009492.1.310 Q16719 KYNU_HUMAN 71.706 0.994819 0.830108 KYNU - Kynureninase - Homo sapiens (Human) - KYNU gene Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Indicus|evm.model.CM009492.1.312 Q16778 H2B2E_HUMAN 89.552 0.970588 0.539683 H2BC21 - Histone H2B type 2-E - Homo sapiens (Human) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009492.1.317 Q8VH49 HIG1A_RAT 83.871 0.938776 1.05376 Higd1a - HIG1 domain family member 1A, mitochondrial - Rattus norvegicus (Rat) - Higd1a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Indicus|evm.model.CM009492.1.319 Q9NZR2 LRP1B_HUMAN 85.143 0.966667 0.0391389 LRP1B - Low-density lipoprotein receptor-related protein 1B precursor - Homo sapiens (Human) - LRP1B gene Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. Indicus|evm.model.CM009492.1.321 Q9NZR2 LRP1B_HUMAN 81.786 0.861386 0.131768 LRP1B - Low-density lipoprotein receptor-related protein 1B precursor - Homo sapiens (Human) - LRP1B gene Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. Indicus|evm.model.CM009492.1.322 Q9NZR2 LRP1B_HUMAN 76.103 0.947368 0.049576 LRP1B - Low-density lipoprotein receptor-related protein 1B precursor - Homo sapiens (Human) - LRP1B gene Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. Indicus|evm.model.CM009492.1.323 Q9NZR2 LRP1B_HUMAN 96.694 0.740741 0.035225 LRP1B - Low-density lipoprotein receptor-related protein 1B precursor - Homo sapiens (Human) - LRP1B gene Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. Indicus|evm.model.CM009492.1.325 Q9NZR2 LRP1B_HUMAN 97.814 0.98913 0.0400087 LRP1B - Low-density lipoprotein receptor-related protein 1B precursor - Homo sapiens (Human) - LRP1B gene Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. Indicus|evm.model.CM009492.1.326 Q9UHQ1 NARF_HUMAN 76.087 0.236842 0.416667 NARF - Nuclear prelamin A recognition factor - Homo sapiens (Human) - NARF gene lamin filament, nuclear lamina, nuclear lumen, nucleolus, nucleoplasm, lamin binding Indicus|evm.model.CM009492.1.327 P16116 ALDR_BOVIN 78.413 0.989619 0.91746 AKR1B1 - Aldo-keto reductase family 1 member B1 - Bos taurus (Bovine) - AKR1B1 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Indicus|evm.model.CM009492.1.328 Q5PSV4 BRM1L_HUMAN 98.246 0.965986 0.910217 BRMS1L - Breast cancer metastasis-suppressor 1-like protein - Homo sapiens (Human) - BRMS1L gene Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth. Indicus|evm.model.CM009492.1.329 Q28145 NXPH2_BOVIN 100.000 0.992453 1.00379 NXPH2 - Neurexophilin-2 precursor - Bos taurus (Bovine) - NXPH2 gene May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Indicus|evm.model.CM009492.1.330 Q6IQ16 SPOPL_HUMAN 97.959 0.944444 1.05612 SPOPL - Speckle-type POZ protein-like - Homo sapiens (Human) - SPOPL gene Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. Indicus|evm.model.CM009492.1.332 Q58DV7 HNMT_BOVIN 92.079 0.993421 1.0411 HNMT - Histamine N-methyltransferase - Bos taurus (Bovine) - HNMT gene Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. Indicus|evm.model.CM009492.1.333 Q2HJH8 CF300_BOVIN 98.958 0.979381 0.363296 CFAP300 - Cilia- and flagella-associated protein 300 - Bos taurus (Bovine) - CFAP300 gene Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly. Indicus|evm.model.CM009492.1.334 Q9C0I4 THS7B_HUMAN 90.933 0.997413 0.48132 THSD7B - Thrombospondin type-1 domain-containing protein 7B precursor - Homo sapiens (Human) - THSD7B gene plasma membrane, actin cytoskeleton reorganization Indicus|evm.model.CM009492.1.337 P09651 ROA1_HUMAN 96.371 0.801948 0.827957 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Homo sapiens (Human) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). Indicus|evm.model.CM009492.1.339 P25930 CXCR4_BOVIN 99.717 0.99435 1.00283 CXCR4 - C-X-C chemokine receptor type 4 - Bos taurus (Bovine) - CXCR4 gene Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). Indicus|evm.model.CM009492.1.340 Q3SYZ4 SYDC_BOVIN 99.202 0.996016 1.002 DARS1 - Aspartate--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - DARS1 gene Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Indicus|evm.model.CM009492.1.341 Q2KIZ8 MCM6_BOVIN 99.594 0.277757 3.2363 MCM6 - DNA replication licensing factor MCM6 - Bos taurus (Bovine) - MCM6 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Indicus|evm.model.CM009492.1.342 Q3ZBU9 UBXN4_BOVIN 99.803 0.996071 1.00197 UBXN4 - UBX domain-containing protein 4 - Bos taurus (Bovine) - UBXN4 gene Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. Indicus|evm.model.CM009492.1.343 Q8K003 TMA7_MOUSE 95.349 0.626866 1.04688 Tma7 - Translation machinery-associated protein 7 - Mus musculus (Mouse) - Tma7 gene cytoplasmic translation Indicus|evm.model.CM009492.1.344 Q15032 R3HD1_HUMAN 91.293 0.998235 1.03094 R3HDM1 - R3H domain-containing protein 1 - Homo sapiens (Human) - R3HDM1 gene RNA binding Indicus|evm.model.CM009492.1.347 E1BB03 ZRAB3_BOVIN 99.507 0.998022 0.941341 ZRANB3 - DNA annealing helicase and endonuclease ZRANB3 - Bos taurus (Bovine) - ZRANB3 gene DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. Indicus|evm.model.CM009492.1.348 Q15042 RB3GP_HUMAN 95.214 0.997965 1.00204 RAB3GAP1 - Rab3 GTPase-activating protein catalytic subunit - Homo sapiens (Human) - RAB3GAP1 gene Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. Indicus|evm.model.CM009492.1.349 Q56UN5 M3K19_HUMAN 73.145 0.863005 1.1378 MAP3K19 - Mitogen-activated protein kinase kinase kinase 19 - Homo sapiens (Human) - MAP3K19 gene Indicus|evm.model.CM009492.1.350 O60583 CCNT2_HUMAN 93.533 0.948872 0.910959 CCNT2 - Cyclin-T2 - Homo sapiens (Human) - CCNT2 gene Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). Indicus|evm.model.CM009492.1.351 Q0II68 ACMSD_BOVIN 100.000 0.994065 1.00298 ACMSD - 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase - Bos taurus (Bovine) - ACMSD gene Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway (By similarity). Indicus|evm.model.CM009492.1.353 Q09328 MGT5A_HUMAN 95.951 0.913366 1.09042 MGAT5 - Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A precursor - Homo sapiens (Human) - MGAT5 gene Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2 (PubMed:10395745, PubMed:22614033, PubMed:30140003). Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling. Required for efficient interaction between TGFB1 and its receptor. Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF. MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways. Promotes cell migration. Contributes to the regulation of the inflammatory response. MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens. Required for normal leukocyte evasation and accumulation at sites of inflammation (By similarity). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis (PubMed:22614033). Indicus|evm.model.CM009492.1.355 O14513 NCKP5_HUMAN 71.751 0.974912 0.897852 NCKAP5 - Nck-associated protein 5 - Homo sapiens (Human) - NCKAP5 gene microtubule plus-end, microtubule bundle formation, microtubule depolymerization Indicus|evm.model.CM009492.1.356 Q8N2G4 LYPD1_HUMAN 92.908 0.985915 1.00709 LYPD1 - Ly6/PLAUR domain-containing protein 1 precursor - Homo sapiens (Human) - LYPD1 gene Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety. Indicus|evm.model.CM009492.1.357 B4XF06 GPR39_BOVIN 100.000 0.755656 0.486784 GPR39 - G-protein coupled receptor 39 - Bos taurus (Bovine) - GPR39 gene Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity). Indicus|evm.model.CM009492.1.358 B4XF06 GPR39_BOVIN 100.000 0.916129 0.682819 GPR39 - G-protein coupled receptor 39 - Bos taurus (Bovine) - GPR39 gene Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity). Indicus|evm.model.CM009492.1.359 A6QL92 S35F5_BOVIN 100.000 0.99619 1.00191 SLC35F5 - Solute carrier family 35 member F5 - Bos taurus (Bovine) - SLC35F5 gene Putative solute transporter. Indicus|evm.model.CM009492.1.360 Q5R8R1 ARP3_PONAB 100.000 0.994565 0.880383 ACTR3 - Actin-related protein 3 - Pongo abelii (Sumatran orangutan) - ACTR3 gene ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis. Indicus|evm.model.CM009492.1.361 Q3TUA9 SG196_MOUSE 56.548 0.963211 0.856734 Pomk - Protein O-mannose kinase - Mus musculus (Mouse) - Pomk gene Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity). Indicus|evm.model.CM009492.1.365 Q8N608 DPP10_HUMAN 90.231 0.997135 0.876884 DPP10 - Inactive dipeptidyl peptidase 10 - Homo sapiens (Human) - DPP10 gene Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155). Indicus|evm.model.CM009492.1.371 Q9NVP1 DDX18_HUMAN 88.125 0.838371 1.13582 DDX18 - ATP-dependent RNA helicase DDX18 - Homo sapiens (Human) - DDX18 gene Probable RNA-dependent helicase. Indicus|evm.model.CM009492.1.372 P35365 5HT5B_RAT 87.027 0.983957 1.01081 Htr5b - 5-hydroxytryptamine receptor 5B - Rattus norvegicus (Rat) - Htr5b gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Probably involved in anxiety and depression. Indicus|evm.model.CM009492.1.373 Q567U6 CCD93_HUMAN 89.382 0.996683 0.955626 CCDC93 - Coiled-coil domain-containing protein 93 - Homo sapiens (Human) - CCDC93 gene Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:28892079, PubMed:25355947). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947). Indicus|evm.model.CM009492.1.374 Q9Y5U4 INSI2_HUMAN 99.111 0.99115 1.00444 INSIG2 - Insulin-induced gene 2 protein - Homo sapiens (Human) - INSIG2 gene Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:26160948, PubMed:17428920, PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (PubMed:16606821, PubMed:22143767). Indicus|evm.model.CM009492.1.377 P09065 HME1_MOUSE 90.789 0.980456 0.765586 En1 - Homeobox protein engrailed-1 - Mus musculus (Mouse) - En1 gene membrane, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, adult locomotory behavior, cerebellum development, dopaminergic neuron differentiation, dorsal/ventral pattern formation Indicus|evm.model.CM009492.1.379 Q9UEW3 MARCO_HUMAN 66.312 0.695652 0.751923 MARCO - Macrophage receptor MARCO - Homo sapiens (Human) - MARCO gene Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263). Indicus|evm.model.CM009492.1.380 Q8CFR0 C1QL2_MOUSE 96.167 0.993056 1.00348 C1ql2 - Complement C1q-like protein 2 precursor - Mus musculus (Mouse) - C1ql2 gene May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Indicus|evm.model.CM009492.1.381 P16116 ALDR_BOVIN 79.167 0.904762 0.4 AKR1B1 - Aldo-keto reductase family 1 member B1 - Bos taurus (Bovine) - AKR1B1 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Indicus|evm.model.CM009492.1.382 Q658P3 STEA3_HUMAN 88.843 0.995876 0.993852 STEAP3 - Metalloreductase STEAP3 - Homo sapiens (Human) - STEAP3 gene Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. Indicus|evm.model.CM009492.1.383 Q32KX9 CB076_BOVIN 99.206 0.984252 1.00794 UPF0538 protein C2orf76 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009492.1.384 P07107 ACBP_BOVIN 100.000 0.977273 1.01149 DBI - Acyl-CoA-binding protein - Bos taurus (Bovine) - DBI gene Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. Indicus|evm.model.CM009492.1.386 Q8WXS4 CCGL_HUMAN 69.036 0.960784 1.07368 TMEM37 - Voltage-dependent calcium channel gamma-like subunit - Homo sapiens (Human) - TMEM37 gene Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity). Indicus|evm.model.CM009492.1.387 P47872 SCTR_HUMAN 89.504 0.857143 0.906818 SCTR - Secretin receptor precursor - Homo sapiens (Human) - SCTR gene Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:7612008, PubMed:25332973). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity). Indicus|evm.model.CM009492.1.388 P23811 SCTR_RAT 59.459 0.336449 0.238307 Sctr - Secretin receptor precursor - Rattus norvegicus (Rat) - Sctr gene Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973, PubMed:12403838). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:9506976, PubMed:12403838). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity). Indicus|evm.model.CM009492.1.389 Q4G0U5 PCDP1_HUMAN 75.782 0.986505 0.882143 CFAP221 - Cilia- and flagella-associated protein 221 - Homo sapiens (Human) - CFAP221 gene May play a role in cilium morphogenesis. Indicus|evm.model.CM009492.1.390 Q4KM93 TM177_RAT 82.524 0.987179 1.00322 Tmem177 - Transmembrane protein 177 - Rattus norvegicus (Rat) - Tmem177 gene Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. Indicus|evm.model.CM009492.1.392 Q58CU2 E41L5_BOVIN 99.775 0.612725 1.44024 EPB41L5 - Band 4.1-like protein 5 - Bos taurus (Bovine) - EPB41L5 gene Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. Indicus|evm.model.CM009492.1.393 Q08DE2 T185B_BOVIN 100.000 0.994302 1.00286 TMEM185B - Transmembrane protein 185B - Bos taurus (Bovine) - TMEM185B gene Indicus|evm.model.CM009492.1.394 Q5R4B8 RALB_PONAB 98.544 0.990338 1.00485 RALB - Ras-related protein Ral-B precursor - Pongo abelii (Sumatran orangutan) - RALB gene Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity). Indicus|evm.model.CM009492.1.395 P42917 INHBB_BOVIN 99.746 0.994924 0.965686 INHBB - Inhibin beta B chain precursor - Bos taurus (Bovine) - INHBB gene Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Indicus|evm.model.CM009492.1.396 Q3MHL7 TCPZ_BOVIN 95.652 0.44186 0.485876 CCT6A - T-complex protein 1 subunit zeta - Bos taurus (Bovine) - CCT6A gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.CM009492.1.397 P10070 GLI2_HUMAN 91.144 0.561044 0.893443 GLI2 - Zinc finger protein GLI2 - Homo sapiens (Human) - GLI2 gene Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). Indicus|evm.model.CM009492.1.398 Q9NZI6 TF2L1_HUMAN 96.660 0.995833 1.00209 TFCP2L1 - Transcription factor CP2-like protein 1 - Homo sapiens (Human) - TFCP2L1 gene Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752). Indicus|evm.model.CM009492.1.400 Q7Z460 CLAP1_HUMAN 92.442 0.998643 0.958388 CLASP1 - CLIP-associating protein 1 - Homo sapiens (Human) - CLASP1 gene Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Indicus|evm.model.CM009492.1.401 Q3SZM1 MK67I_BOVIN 100.000 0.993266 1.00338 NIFK - MKI67 FHA domain-interacting nucleolar phosphoprotein - Bos taurus (Bovine) - NIFK gene nucleolus, RNA binding, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009492.1.402 Q08DM8 TSN_BOVIN 100.000 0.991266 1.00439 TSN - Translin - Bos taurus (Bovine) - TSN gene DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots (By similarity). Indicus|evm.model.CM009492.1.403 Q9HBK9 AS3MT_HUMAN 74.684 0.709091 0.293333 AS3MT - Arsenite methyltransferase - Homo sapiens (Human) - AS3MT gene Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed:16407288, PubMed:25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655). Indicus|evm.model.CM009492.1.405 P62936 PPIA_PIG 80.368 0.911765 1.03659 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009492.1.406 O02739 SPB6_BOVIN 64.286 0.859375 0.169312 SERPINB6 - Serpin B6 - Bos taurus (Bovine) - SERPINB6 gene Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress (By similarity). May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Indicus|evm.model.CM009492.1.408 Q8IVU1 IGDC3_HUMAN 58.785 0.994505 0.447174 IGDCC3 - Immunoglobulin superfamily DCC subclass member 3 precursor - Homo sapiens (Human) - IGDCC3 gene Indicus|evm.model.CM009492.1.409 Q0V8T0 CNTP5_CANLF 100.000 0.851351 0.056705 CNTNAP5 - Contactin-associated protein-like 5 precursor - Canis lupus familiaris (Dog) - CNTNAP5 gene May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. Indicus|evm.model.CM009492.1.411 Q0V8T0 CNTP5_CANLF 95.215 0.995227 0.321073 CNTNAP5 - Contactin-associated protein-like 5 precursor - Canis lupus familiaris (Dog) - CNTNAP5 gene May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. Indicus|evm.model.CM009492.1.412 Q8WYK1 CNTP5_HUMAN 86.765 0.41875 0.122511 CNTNAP5 - Contactin-associated protein-like 5 precursor - Homo sapiens (Human) - CNTNAP5 gene May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. Indicus|evm.model.CM009492.1.413 Q8WYK1 CNTP5_HUMAN 86.875 0.989627 0.369066 CNTNAP5 - Contactin-associated protein-like 5 precursor - Homo sapiens (Human) - CNTNAP5 gene May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. Indicus|evm.model.CM009492.1.414 Q5E954 DNJA1_BOVIN 90.176 0.99455 0.924433 DNAJA1 - DnaJ homolog subfamily A member 1 precursor - Bos taurus (Bovine) - DNAJA1 gene Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Indicus|evm.model.CM009492.1.415 Q96LD8 SENP8_HUMAN 77.251 0.914692 0.995283 SENP8 - Sentrin-specific protease 8 - Homo sapiens (Human) - SENP8 gene Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. Indicus|evm.model.CM009492.1.416 O43166 SI1L1_HUMAN 98.667 0.973684 0.0421286 SIPA1L1 - Signal-induced proliferation-associated 1-like protein 1 - Homo sapiens (Human) - SIPA1L1 gene Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). Indicus|evm.model.CM009492.1.417 Q9JLY0 SOCS6_MOUSE 49.550 0.419847 0.491557 Socs6 - Suppressor of cytokine signaling 6 - Mus musculus (Mouse) - Socs6 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity). Indicus|evm.model.CM009492.1.418 Q9JLY0 SOCS6_MOUSE 68.041 0.976879 0.324578 Socs6 - Suppressor of cytokine signaling 6 - Mus musculus (Mouse) - Socs6 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity). Indicus|evm.model.CM009492.1.419 Q78HU7 GLPC_MOUSE 79.310 0.518182 1.15789 Gypc - Glycophorin-C - Mus musculus (Mouse) - Gypc gene cortical cytoskeleton, membrane, plasma membrane Indicus|evm.model.CM009492.1.421 A0A1B0GUA7 TEX51_HUMAN 48.235 0.597173 1.70482 TEX51 - Testis-expressed protein 51 precursor - Homo sapiens (Human) - TEX51 gene Indicus|evm.model.CM009492.1.422 D3Z7P3 GLSK_MOUSE 94.830 0.997041 1.00297 Gls - Glutaminase kidney isoform, mitochondrial precursor - Mus musculus (Mouse) - Gls gene Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain. Indicus|evm.model.CM009492.1.423 Q764M5 STAT1_PIG 97.181 0.992 0.990753 STAT1 - Signal transducer and activator of transcription 1 - Sus scrofa (Pig) - STAT1 gene Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Indicus|evm.model.CM009492.1.425 Q14765 STAT4_HUMAN 96.538 0.99734 1.00535 STAT4 - Signal transducer and activator of transcription 4 - Homo sapiens (Human) - STAT4 gene Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling. Indicus|evm.model.CM009492.1.426 O43795 MYO1B_HUMAN 98.151 0.984389 1.01496 MYO1B - Unconventional myosin-Ib - Homo sapiens (Human) - MYO1B gene Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport. Indicus|evm.model.CM009492.1.427 A5D7P8 SOSB2_BOVIN 99.515 0.990338 1.00485 NABP1 - SOSS complex subunit B2 - Bos taurus (Bovine) - NABP1 gene Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). Indicus|evm.model.CM009492.1.428 O95810 CAVN2_HUMAN 87.042 0.99511 0.962353 CAVIN2 - Caveolae-associated protein 2 - Homo sapiens (Human) - CAVIN2 gene Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). Indicus|evm.model.CM009492.1.431 Q29RK4 RD23B_BOVIN 79.167 0.994152 0.838235 RAD23B - UV excision repair protein RAD23 homolog B - Bos taurus (Bovine) - RAD23B gene Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity). Indicus|evm.model.CM009492.1.433 Q9ULF5 S39AA_HUMAN 92.317 0.997602 1.00361 SLC39A10 - Zinc transporter ZIP10 precursor - Homo sapiens (Human) - SLC39A10 gene May act as a zinc-influx transporter. Indicus|evm.model.CM009492.1.434 Q8WXX0 DYH7_HUMAN 92.371 0.999503 1.00025 DNAH7 - Dynein axonemal heavy chain 7 - Homo sapiens (Human) - DNAH7 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Indicus|evm.model.CM009492.1.435 O94768 ST17B_HUMAN 93.280 0.994638 1.00269 STK17B - Serine/threonine-protein kinase 17B - Homo sapiens (Human) - STK17B gene Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis. Indicus|evm.model.CM009492.1.436 Q9P2P5 HECW2_HUMAN 99.343 0.989583 0.48855 HECW2 - E3 ubiquitin-protein ligase HECW2 - Homo sapiens (Human) - HECW2 gene E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). Indicus|evm.model.CM009492.1.437 Q9P2P5 HECW2_HUMAN 90.577 0.90087 0.365776 HECW2 - E3 ubiquitin-protein ligase HECW2 - Homo sapiens (Human) - HECW2 gene E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). Indicus|evm.model.CM009492.1.438 Q9P2P5 HECW2_HUMAN 98.193 0.926966 0.113232 HECW2 - E3 ubiquitin-protein ligase HECW2 - Homo sapiens (Human) - HECW2 gene E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). Indicus|evm.model.CM009492.1.439 Q9P2P5 HECW2_HUMAN 97.980 0.852174 0.0731552 HECW2 - E3 ubiquitin-protein ligase HECW2 - Homo sapiens (Human) - HECW2 gene E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). Indicus|evm.model.CM009492.1.441 Q8NCX0 CC150_HUMAN 78.080 0.945971 0.991826 CCDC150 - Coiled-coil domain-containing protein 150 - Homo sapiens (Human) - CCDC150 gene Indicus|evm.model.CM009492.1.442 Q9Y5Q9 TF3C3_HUMAN 95.147 0.997743 1 GTF3C3 - General transcription factor 3C polypeptide 3 - Homo sapiens (Human) - GTF3C3 gene Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. Indicus|evm.model.CM009492.1.443 Q75T13 PGAP1_HUMAN 92.516 0.997833 1.00108 PGAP1 - GPI inositol-deacylase - Homo sapiens (Human) - PGAP1 gene Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). Indicus|evm.model.CM009492.1.444 Q8N8A2 ANR44_HUMAN 97.155 0.918605 1.03927 ANKRD44 - Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B - Homo sapiens (Human) - ANKRD44 gene Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Indicus|evm.model.CM009492.1.445 A8D8X1 RL10_SHEEP 83.544 0.975 0.373832 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009492.1.446 Q9NR23 GDF3_HUMAN 78.142 0.994521 1.00275 GDF3 - Growth/differentiation factor 3 precursor - Homo sapiens (Human) - GDF3 gene Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089). Indicus|evm.model.CM009492.1.447 O75533 SF3B1_HUMAN 99.923 0.845199 1.17408 SF3B1 - Splicing factor 3B subunit 1 - Homo sapiens (Human) - SF3B1 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). Indicus|evm.model.CM009492.1.448 Q5I0I9 CQ10B_RAT 97.333 0.861272 0.720833 Coq10b - Coenzyme Q-binding protein COQ10 homolog B, mitochondrial precursor - Rattus norvegicus (Rat) - Coq10b gene Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity). Indicus|evm.model.CM009492.1.449 P31081 CH60_BOVIN 99.302 0.956522 1.04363 HSPD1 - 60 kDa heat shock protein, mitochondrial precursor - Bos taurus (Bovine) - HSPD1 gene Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. Indicus|evm.model.CM009492.1.451 P61604 CH10_HUMAN 100.000 0.980583 1.0098 HSPE1 - 10 kDa heat shock protein, mitochondrial - Homo sapiens (Human) - HSPE1 gene Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). Indicus|evm.model.CM009492.1.452 Q9QYW3 PHOCN_RAT 100.000 0.99115 1.00444 Mob4 - MOB-like protein phocein - Rattus norvegicus (Rat) - Mob4 gene May play a role in membrane trafficking, specifically in membrane budding reactions. Indicus|evm.model.CM009492.1.453 Q52LD8 RFTN2_HUMAN 86.427 0.995992 0.996008 RFTN2 - Raftlin-2 - Homo sapiens (Human) - RFTN2 gene Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. Indicus|evm.model.CM009492.1.454 A6H7E1 SYMM_BOVIN 100.000 0.996633 1.00169 MARS2 - Methionine--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - MARS2 gene methionine-tRNA ligase activity, methionyl-tRNA aminoacylation Indicus|evm.model.CM009492.1.455 Q924M5 BOLL_MOUSE 96.739 0.737265 1.3274 Boll - Protein boule-like - Mus musculus (Mouse) - Boll gene Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity). Indicus|evm.model.CM009492.1.457 Q9UHD8 SEPT9_HUMAN 88.571 0.958333 0.122867 SEPTIN9 - Septin-9 - Homo sapiens (Human) - SEPTIN9 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. Indicus|evm.model.CM009492.1.458 Q15111 PLCL1_HUMAN 96.752 0.972222 0.953425 PLCL1 - Inactive phospholipase C-like protein 1 - Homo sapiens (Human) - PLCL1 gene Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. Indicus|evm.model.CM009492.1.459 Q9UPW6 SATB2_HUMAN 99.006 0.699164 0.979536 SATB2 - DNA-binding protein SATB2 - Homo sapiens (Human) - SATB2 gene Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Indicus|evm.model.CM009492.1.460 E5RQL4 FONG_HUMAN 80.451 0.47482 1.89116 FTCDNL1 - Formiminotransferase N-terminal subdomain-containing protein precursor - Homo sapiens (Human) - FTCDNL1 gene Indicus|evm.model.CM009492.1.461 Q8N8R5 CB069_HUMAN 88.205 0.994885 1.01558 C2orf69 - UPF0565 protein C2orf69 precursor - Homo sapiens (Human) - C2orf69 gene Indicus|evm.model.CM009492.1.462 A2RUC4 TYW5_HUMAN 92.381 0.993671 1.00317 TYW5 - tRNA wybutosine-synthesizing protein 5 - Homo sapiens (Human) - TYW5 gene tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. Indicus|evm.model.CM009492.1.463 A3KN05 MAIP1_BOVIN 100.000 0.992509 0.917526 MAIP1 - m-AAA protease-interacting protein 1, mitochondrial precursor - Bos taurus (Bovine) - MAIP1 gene Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). Indicus|evm.model.CM009492.1.464 P84232 H32_PORAF 98.529 0.985401 1.00735 Histone H3.2 - Poroderma africanum (Striped catshark) Indicus|evm.model.CM009492.1.465 Q9NUQ6 SPS2L_HUMAN 94.040 0.276753 0.971326 SPATS2L - SPATS2-like protein - Homo sapiens (Human) - SPATS2L gene cytoplasm, cytosol, nucleolus, nucleoplasm, protein-containing complex, RNA binding Indicus|evm.model.CM009492.1.466 Q29RJ0 KCD18_BOVIN 100.000 0.995272 1.00237 KCTD18 - BTB/POZ domain-containing protein KCTD18 - Bos taurus (Bovine) - KCTD18 gene Indicus|evm.model.CM009492.1.467 P48034 AOXA_BOVIN 96.863 0.489456 2.01867 AOX1 - Aldehyde oxidase 1 - Bos taurus (Bovine) - AOX1 gene Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Indicus|evm.model.CM009492.1.468 D3ZKU7 BL1S1_RAT 74.400 0.968 1 Bloc1s1 - Biogenesis of lysosome-related organelles complex 1 subunit 1 - Rattus norvegicus (Rat) - Bloc1s1 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Indicus|evm.model.CM009492.1.469 Q3TYQ9 AOXD_MOUSE 82.721 0.998436 0.957335 Aox4 - Aldehyde oxidase 4 - Mus musculus (Mouse) - Aox4 gene Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Is responsible for the major all-trans-retinaldehyde-metabolizing activity in the Harderian gland, and contributes a significant amount of the same activity in the skin. Is devoid of pyridoxal-oxidizing activity, in contrast to the other aldehyde oxidases. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles. Indicus|evm.model.CM009492.1.470 C4NYZ3 AOXB_MACFA 87.333 0.998505 0.991846 AOX2 - Aldehyde oxidase 2 - Macaca fascicularis (Crab-eating macaque) - AOX2 gene Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal. Indicus|evm.model.CM009492.1.471 Q6P7P5 BZW1_RAT 100.000 0.863636 1.15513 Bzw1 - Basic leucine zipper and W2 domain-containing protein 1 - Rattus norvegicus (Rat) - Bzw1 gene Enhances histone H4 gene transcription but does not seem to bind DNA directly. Indicus|evm.model.CM009492.1.472 P49759 CLK1_HUMAN 93.595 0.829897 1.20248 CLK1 - Dual specificity protein kinase CLK1 - Homo sapiens (Human) - CLK1 gene Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. Indicus|evm.model.CM009492.1.473 Q9H2H8 PPIL3_HUMAN 99.259 0.978102 0.850932 PPIL3 - Peptidyl-prolyl cis-trans isomerase-like 3 - Homo sapiens (Human) - PPIL3 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Indicus|evm.model.CM009492.1.474 Q05B89 NIF3L_BOVIN 99.204 0.994709 1.00265 NIF3L1 - NIF3-like protein 1 - Bos taurus (Bovine) - NIF3L1 gene May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. Indicus|evm.model.CM009492.1.475 A6QNM3 ORC2_BOVIN 99.827 0.99654 1.00173 ORC2 - Origin recognition complex subunit 2 - Bos taurus (Bovine) - ORC2 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity). Indicus|evm.model.CM009492.1.476 Q5R977 F126B_PONAB 86.860 0.996593 1.10755 FAM126B - Protein FAM126B - Pongo abelii (Sumatran orangutan) - FAM126B gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. Indicus|evm.model.CM009492.1.477 Q02365 NDUB3_BOVIN 100.000 0.740458 1.33673 NDUFB3 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 - Bos taurus (Bovine) - NDUFB3 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009492.1.478 A5A6H4 ROA1_PANTR 94.340 0.268041 0.60625 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Indicus|evm.model.CM009492.1.480 O15519 CFLAR_HUMAN 73.608 0.941406 1.06667 CFLAR - CASP8 and FADD-like apoptosis regulator precursor - Homo sapiens (Human) - CFLAR gene Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. Indicus|evm.model.CM009492.1.481 Q92851 CASPA_HUMAN 62.500 0.868182 0.422265 CASP10 - Caspase-10 precursor - Homo sapiens (Human) - CASP10 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Indicus|evm.model.CM009492.1.482 Q14790 CASP8_HUMAN 70.722 0.99177 1.01461 CASP8 - Caspase-8 precursor - Homo sapiens (Human) - CASP8 gene Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (By similarity). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death (PubMed:23516580, PubMed:8681376, PubMed:8681377, PubMed:9006941, PubMed:9184224, PubMed:8962078). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor TNFRSF6/FAS mediated or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-D (GSDMD): GSDMD cleavage promoting release of the N-terminal moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (By similarity). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 (PubMed:8681376). Indicus|evm.model.CM009492.1.483 Q96Q35 FACC1_HUMAN 70.112 0.995272 0.950562 FLACC1 - Flagellum-associated coiled-coil domain-containing protein 1 - Homo sapiens (Human) - FLACC1 gene cytoplasm, outer dense fiber, sperm fibrous sheath, sperm flagellum Indicus|evm.model.CM009492.1.484 O60296 TRAK2_HUMAN 89.727 0.997812 1 TRAK2 - Trafficking kinesin-binding protein 2 - Homo sapiens (Human) - TRAK2 gene May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. Indicus|evm.model.CM009492.1.485 Q9C0K7 STRAB_HUMAN 94.258 0.995227 1.00239 STRADB - STE20-related kinase adapter protein beta - Homo sapiens (Human) - STRADB gene Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). Indicus|evm.model.CM009492.1.486 Q53TS8 C2CD6_HUMAN 70.103 0.0515744 2.95666 C2CD6 - C2 calcium-dependent domain-containing protein 6 - Homo sapiens (Human) - C2CD6 gene Indicus|evm.model.CM009492.1.487 E1BN97 TM237_BOVIN 100.000 0.96088 1.0225 TMEM237 - Transmembrane protein 237 - Bos taurus (Bovine) - TMEM237 gene Component of the transition zone in primary cilia. Required for ciliogenesis (By similarity). Indicus|evm.model.CM009492.1.488 Q9QYH1 MPP4_RAT 83.691 0.909804 0.578231 Mpp4 - MAGUK p55 subfamily member 4 - Rattus norvegicus (Rat) - Mpp4 gene May play a role in retinal photoreceptors development. Indicus|evm.model.CM009492.1.489 Q96JB8 MPP4_HUMAN 89.206 0.872222 0.565149 MPP4 - MAGUK p55 subfamily member 4 - Homo sapiens (Human) - MPP4 gene May play a role in retinal photoreceptors development. Indicus|evm.model.CM009492.1.490 Q96Q42 ALS2_HUMAN 94.025 0.998793 1 ALS2 - Alsin - Homo sapiens (Human) - ALS2 gene May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). Indicus|evm.model.CM009492.1.492 O75084 FZD7_HUMAN 97.038 0.996522 1.00174 FZD7 - Frizzled-7 precursor - Homo sapiens (Human) - FZD7 gene Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Indicus|evm.model.CM009492.1.493 A7YY35 K2012_BOVIN 84.825 0.979186 0.921534 KIAA2012 - Uncharacterized protein KIAA2012 homolog - Bos taurus (Bovine) - KIAA2012 gene Indicus|evm.model.CM009492.1.494 Q5I0H3 SUMO1_RAT 100.000 0.478469 2.06931 Sumo1 - Small ubiquitin-related modifier 1 precursor - Rattus norvegicus (Rat) - Sumo1 gene Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3. Indicus|evm.model.CM009492.1.495 Q4R779 NOP58_MACFA 94.991 0.996296 1.01887 NOP58 - Nucleolar protein 58 - Macaca fascicularis (Crab-eating macaque) - NOP58 gene Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity). Indicus|evm.model.CM009492.1.496 Q13873 BMPR2_HUMAN 97.826 0.36108 0.856455 BMPR2 - Bone morphogenetic protein receptor type-2 precursor - Homo sapiens (Human) - BMPR2 gene On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Indicus|evm.model.CM009492.1.497 Q6P1L5 F117B_HUMAN 97.429 0.960396 0.685908 FAM117B - Protein FAM117B - Homo sapiens (Human) - FAM117B gene Indicus|evm.model.CM009492.1.498 Q8NDH6 ICA1L_HUMAN 83.851 0.977642 1.02075 ICA1L - Islet cell autoantigen 1-like protein - Homo sapiens (Human) - ICA1L gene Golgi apparatus, regulation of transport Indicus|evm.model.CM009492.1.499 Q0VC24 WDR12_BOVIN 100.000 0.995283 1.00236 WDR12 - Ribosome biogenesis protein WDR12 - Bos taurus (Bovine) - WDR12 gene Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Indicus|evm.model.CM009492.1.500 Q58CW6 CARTF_BOVIN 99.560 0.943213 1.02703 CARF - Calcium-responsive transcription factor - Bos taurus (Bovine) - CARF gene Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence (By similarity). Indicus|evm.model.CM009492.1.501 Q6ZS30 NBEL1_HUMAN 91.957 0.999266 1.01076 NBEAL1 - Neurobeachin-like protein 1 - Homo sapiens (Human) - NBEAL1 gene cytosol, membrane, protein kinase binding, protein localization Indicus|evm.model.CM009492.1.502 Q5E980 CP20A_BOVIN 100.000 0.99568 1.00216 CYP20A1 - Cytochrome P450 20A1 - Bos taurus (Bovine) - CYP20A1 gene Indicus|evm.model.CM009492.1.503 Q9NYB9 ABI2_HUMAN 92.251 0.996276 1.04678 ABI2 - Abl interactor 2 - Homo sapiens (Human) - ABI2 gene Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). Indicus|evm.model.CM009492.1.504 Q70E73 RAPH1_HUMAN 90.614 0.299674 0.7368 RAPH1 - Ras-associated and pleckstrin homology domains-containing protein 1 - Homo sapiens (Human) - RAPH1 gene Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. Indicus|evm.model.CM009492.1.505 Q28071 CD28_BOVIN 100.000 0.989637 0.881279 CD28 - T-cell-specific surface glycoprotein CD28 precursor - Bos taurus (Bovine) - CD28 gene Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Indicus|evm.model.CM009492.1.506 Q9H175 CSRN2_HUMAN 87.603 0.794702 0.278085 CSRNP2 - Cysteine/serine-rich nuclear protein 2 - Homo sapiens (Human) - CSRNP2 gene Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis. Indicus|evm.model.CM009492.1.507 Q9MYX7 CTLA4_PIG 89.785 0.989305 0.838565 CTLA4 - Cytotoxic T-lymphocyte protein 4 precursor - Sus scrofa (Pig) - CTLA4 gene Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Indicus|evm.model.CM009492.1.511 Q8TEW8 PAR3L_HUMAN 91.600 0.998232 0.938589 PARD3B - Partitioning defective 3 homolog B - Homo sapiens (Human) - PARD3B gene Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. Indicus|evm.model.CM009492.1.512 O60462 NRP2_HUMAN 96.539 0.895787 0.968851 NRP2 - Neuropilin-2 precursor - Homo sapiens (Human) - NRP2 gene High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. Indicus|evm.model.CM009492.1.513 O60462 NRP2_HUMAN 94.167 0.908397 0.140709 NRP2 - Neuropilin-2 precursor - Homo sapiens (Human) - NRP2 gene High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. Indicus|evm.model.CM009492.1.514 Q53TQ3 IN80D_HUMAN 96.495 0.998053 1 INO80D - INO80 complex subunit D - Homo sapiens (Human) - INO80D gene Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Indicus|evm.model.CM009492.1.515 P15690 NDUS1_BOVIN 99.450 0.997253 1.00138 NDUFS1 - NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor - Bos taurus (Bovine) - NDUFS1 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity). Indicus|evm.model.CM009492.1.516 Q5E983 EF1B_BOVIN 100.000 0.99115 1.00444 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Indicus|evm.model.CM009492.1.517 P46091 GPR1_HUMAN 87.887 0.994382 1.00282 GPR1 - G-protein coupled receptor 1 - Homo sapiens (Human) - GPR1 gene Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (PubMed:18165312). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). Indicus|evm.model.CM009492.1.518 Q9HCK1 ZDBF2_HUMAN 52.811 0.996105 0.872557 ZDBF2 - DBF4-type zinc finger-containing protein 2 - Homo sapiens (Human) - ZDBF2 gene Indicus|evm.model.CM009492.1.519 O75077 ADA23_HUMAN 94.118 0.997602 1.0024 ADAM23 - Disintegrin and metalloproteinase domain-containing protein 23 precursor - Homo sapiens (Human) - ADAM23 gene May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein. Indicus|evm.model.CM009492.1.520 A0A1B0GTK4 F237A_HUMAN 85.915 0.886792 0.878453 FAM237A - Protein FAM237A - Homo sapiens (Human) - FAM237A gene Indicus|evm.model.CM009492.1.521 A3KMX7 MDH1B_BOVIN 99.363 0.455426 2.18182 MDH1B - Putative malate dehydrogenase 1B - Bos taurus (Bovine) - MDH1B gene L-malate dehydrogenase activity, malate metabolic process, NADH metabolic process, oxaloacetate metabolic process, tricarboxylic acid cycle Indicus|evm.model.CM009492.1.522 Q9NYY8 FAKD2_HUMAN 69.957 0.995646 0.970423 FASTKD2 - FAST kinase domain-containing protein 2, mitochondrial precursor - Homo sapiens (Human) - FASTKD2 gene Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664, PubMed:25683715, PubMed:26370583). May play a role in mitochondrial apoptosis. Indicus|evm.model.CM009492.1.523 Q0II73 CBPO_BOVIN 92.784 0.680851 0.376 CPO - Carboxypeptidase O precursor - Bos taurus (Bovine) - CPO gene Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues. Indicus|evm.model.CM009492.1.524 Q5R893 H2B1_PONAB 92.063 0.984127 1 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009492.1.525 Q0II73 CBPO_BOVIN 99.303 0.972789 0.784 CPO - Carboxypeptidase O precursor - Bos taurus (Bovine) - CPO gene Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues. Indicus|evm.model.CM009492.1.526 O75840 KLF7_HUMAN 97.020 0.993399 1.00331 KLF7 - Krueppel-like factor 7 - Homo sapiens (Human) - KLF7 gene Transcriptional factor (PubMed:9774444, PubMed:16339272). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed:28916725). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272). Indicus|evm.model.CM009492.1.527 Q2HJE9 TI17B_BOVIN 50.581 0.980583 0.598837 TIMM17B - Mitochondrial import inner membrane translocase subunit Tim17-B - Bos taurus (Bovine) - TIMM17B gene Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Indicus|evm.model.CM009492.1.528 P27925 CREB1_BOVIN 100.000 0.987805 1.00923 CREB1 - Cyclic AMP-responsive element-binding protein 1 - Bos taurus (Bovine) - CREB1 gene Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Indicus|evm.model.CM009492.1.529 A4FV42 MT21A_BOVIN 99.541 0.990868 1.00459 METTL21A - Protein N-lysine methyltransferase METTL21A - Bos taurus (Bovine) - METTL21A gene Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8 (By similarity). Indicus|evm.model.CM009492.1.530 Q96G01 BICD1_HUMAN 89.394 0.692308 0.0933333 BICD1 - Protein bicaudal D homolog 1 - Homo sapiens (Human) - BICD1 gene Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. Indicus|evm.model.CM009492.1.531 Q8N7R7 CCYL1_HUMAN 93.388 0.994505 1.01393 CCNYL1 - Cyclin-Y-like protein 1 - Homo sapiens (Human) - CCNYL1 gene cytoplasm, plasma membrane, cyclin-dependent protein serine/threonine kinase regulator activity, positive regulation of cyclin-dependent protein serine/threonine kinase activity Indicus|evm.model.CM009492.1.532 Q13467 FZD5_HUMAN 92.137 0.996587 1.00171 FZD5 - Frizzled-5 precursor - Homo sapiens (Human) - FZD5 gene Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). Indicus|evm.model.CM009492.1.533 Q6ZWE6 PKHM3_HUMAN 90.407 0.997358 0.994744 PLEKHM3 - Pleckstrin homology domain-containing family M member 3 - Homo sapiens (Human) - PLEKHM3 gene Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. Indicus|evm.model.CM009492.1.534 P23005 CRGF_BOVIN 95.402 0.988571 1.00575 CRYGF - Gamma-crystallin F - Bos taurus (Bovine) - CRYGF gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009492.1.535 P62986 RL40_RAT 78.761 0.982143 0.875 Uba52 - Ubiquitin-60S ribosomal protein L40 precursor - Rattus norvegicus (Rat) - Uba52 gene Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). Indicus|evm.model.CM009492.1.536 P08209 CRGD_BOVIN 99.425 0.988571 1.00575 CRYGD - Gamma-crystallin D - Bos taurus (Bovine) - CRYGD gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009492.1.537 Q28088 CRGC_BOVIN 100.000 0.988571 1.00575 CRYGC - Gamma-crystallin C - Bos taurus (Bovine) - CRYGC gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009492.1.538 P02526 CRGB_BOVIN 100.000 0.988636 1.00571 CRYGB - Gamma-crystallin B - Bos taurus (Bovine) - CRYGB gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009492.1.539 P10065 CRGA_RAT 90.805 0.988571 1.00575 Cryga - Gamma-crystallin A - Rattus norvegicus (Rat) - Cryga gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009492.1.540 Q0P641 CB080_HUMAN 80.829 0.945813 1.05181 C2orf80 - Uncharacterized protein C2orf80 - Homo sapiens (Human) - C2orf80 gene Indicus|evm.model.CM009492.1.541 Q9XSG3 IDHC_BOVIN 99.758 0.995181 1.00242 IDH1 - Isocitrate dehydrogenase [NADP] cytoplasmic - Bos taurus (Bovine) - IDH1 gene May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. Indicus|evm.model.CM009492.1.542 Q9Y2I7 FYV1_HUMAN 94.662 0.997147 1.00238 PIKFYVE - 1-phosphatidylinositol 3-phosphate 5-kinase - Homo sapiens (Human) - PIKFYVE gene Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation downregulates lipid product formation (By similarity). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, trhough association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). Indicus|evm.model.CM009492.1.543 Q8N5Y2 MS3L1_HUMAN 91.549 0.994382 0.683301 MSL3 - Male-specific lethal 3 homolog - Homo sapiens (Human) - MSL3 gene Has a role in chromatin remodeling and transcriptional regulation (PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647). Has a role in X inactivation (PubMed:21217699). Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure (PubMed:16227571, PubMed:20657587, PubMed:16543150, PubMed:30224647). Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). Indicus|evm.model.CM009492.1.544 P49190 PTH2R_HUMAN 90.937 0.681818 0.88 PTH2R - Parathyroid hormone 2 receptor precursor - Homo sapiens (Human) - PTH2R gene This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). Indicus|evm.model.CM009492.1.545 P23005 CRGF_BOVIN 100.000 0.988571 1.00575 CRYGF - Gamma-crystallin F - Bos taurus (Bovine) - CRYGF gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009492.1.546 P15146 MTAP2_RAT 96.286 0.695219 0.269747 Map2 - Microtubule-associated protein 2 - Rattus norvegicus (Rat) - Map2 gene The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. Indicus|evm.model.CM009492.1.548 Q8VEE0 RPE_MOUSE 97.561 0.5 0.350877 Rpe - Ribulose-phosphate 3-epimerase - Mus musculus (Mouse) - Rpe gene Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. Indicus|evm.model.CM009492.1.549 Q8VEE0 RPE_MOUSE 96.257 0.180583 4.51754 Rpe - Ribulose-phosphate 3-epimerase - Mus musculus (Mouse) - Rpe gene Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. Indicus|evm.model.CM009492.1.550 P79274 ACADL_PIG 86.279 0.995261 0.981395 ACADL - Long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Sus scrofa (Pig) - ACADL gene Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (By similarity). Indicus|evm.model.CM009492.1.551 Q92982 NINJ1_HUMAN 90.435 0.982759 0.763158 NINJ1 - Ninjurin-1 - Homo sapiens (Human) - NINJ1 gene Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis (PubMed:8780658, PubMed:9261151, PubMed:33472215). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) (PubMed:33028854). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells (PubMed:22162058, PubMed:26677008, PubMed:32147432). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (PubMed:22162058). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (PubMed:26677008). Acts as a mediator of both programmed and necrotic cell death (PubMed:33472215). Plays a key role in the induction of plasma membrane rupture during programmed and necrotic cell death: oligomerizes in response to death stimuli to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (PubMed:33472215). Plays a role in nerve regeneration by promoting maturation of Schwann cells (PubMed:8780658, PubMed:9261151). Acts as a regulator of angiogenesis (PubMed:33028854). Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (By similarity). Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts (By similarity). Also involved in striated muscle growth and differentiation (By similarity). Indicus|evm.model.CM009492.1.552 A0JNJ5 MYL1_BOVIN 100.000 0.989637 1.00521 MYL1 - Myosin light chain 1/3, skeletal muscle isoform - Bos taurus (Bovine) - MYL1 gene Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. Indicus|evm.model.CM009492.1.553 F1MVX2 LANC1_BOVIN 99.749 0.837895 1.19048 LANCL1 - Glutathione S-transferase LANCL1 - Bos taurus (Bovine) - LANCL1 gene Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling (By similarity). Binds glutathione (PubMed:17305318). Indicus|evm.model.CM009492.1.554 P31327 CPSM_HUMAN 95.357 0.997234 0.964 CPS1 - Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor - Homo sapiens (Human) - CPS1 gene Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. Indicus|evm.model.CM009492.1.555 Q61527 ERBB4_MOUSE 94.400 0.992032 0.191896 Erbb4 - Receptor tyrosine-protein kinase erbB-4 precursor - Mus musculus (Mouse) - Erbb4 gene Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. Indicus|evm.model.CM009492.1.556 Q61527 ERBB4_MOUSE 99.083 0.915612 0.181193 Erbb4 - Receptor tyrosine-protein kinase erbB-4 precursor - Mus musculus (Mouse) - Erbb4 gene Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. Indicus|evm.model.CM009492.1.557 Q15303 ERBB4_HUMAN 93.961 0.972826 0.422018 ERBB4 - Receptor tyrosine-protein kinase erbB-4 precursor - Homo sapiens (Human) - ERBB4 gene Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. Indicus|evm.model.CM009492.1.559 Q15303 ERBB4_HUMAN 100.000 0.98 0.0382263 ERBB4 - Receptor tyrosine-protein kinase erbB-4 precursor - Homo sapiens (Human) - ERBB4 gene Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. Indicus|evm.model.CM009492.1.561 Q63273 GRIK5_RAT 96.429 0.402985 0.0684372 Grik5 - Glutamate receptor ionotropic, kainate 5 precursor - Rattus norvegicus (Rat) - Grik5 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA. Indicus|evm.model.CM009492.1.562 Q9UKS7 IKZF2_HUMAN 99.430 0.986842 1.01141 IKZF2 - Zinc finger protein Helios - Homo sapiens (Human) - IKZF2 gene Associates with Ikaros at centromeric heterochromatin. Indicus|evm.model.CM009492.1.564 Q32LB0 WDR70_BOVIN 85.938 0.969231 0.0996933 WDR70 - WD repeat-containing protein 70 - Bos taurus (Bovine) - WDR70 gene Indicus|evm.model.CM009492.1.565 Q95K75 VWC2L_MACFA 99.237 0.984848 0.956522 VWC2L - von Willebrand factor C domain-containing protein 2-like precursor - Macaca fascicularis (Crab-eating macaque) - VWC2L gene May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization. Indicus|evm.model.CM009492.1.566 Q99728 BARD1_HUMAN 76.067 0.992958 0.913771 BARD1 - BRCA1-associated RING domain protein 1 - Homo sapiens (Human) - BARD1 gene E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. Indicus|evm.model.CM009492.1.567 Q86UK0 ABCAC_HUMAN 89.260 0.986791 0.991908 ABCA12 - Glucosylceramide transporter ABCA12 - Homo sapiens (Human) - ABCA12 gene Transports lipids such as glucosylceramides from the outer to the inner leaflet of lamellar granules (LGs) membrane, whereby the lipids are finally transported to the keratinocyte periphery via the trans-Golgi network and LGs and released to the apical surface of the granular keratinocytes to form lipid lamellae in the stratum corneum of the epidermis, which is essential for skin barrier function (PubMed:16007253, PubMed:20869849). In the mean time, participates in the transport of the lamellar granules-associated proteolytic enzymes, in turns regulates desquamation and keratinocyte differentiation (PubMed:19179616). Furthermore, is essential for the regulation of cellular cholesterol homeostasis by regulating ABCA1-dependent cholesterol efflux from macrophages through interaction with NR1H2 and ABCA1 (By similarity). Plays pleiotropic roles in regulating glucose stimulated insulin secretion from beta cells, regulating the morphology and fusion of insulin granules, lipid raft abundance and the actin cytoskeleton (By similarity). Also involved in lung surfactant biogenesis (By similarity). Indicus|evm.model.CM009492.1.568 Q0VCK0 PUR9_BOVIN 99.831 0.996627 1.00169 ATIC - Bifunctional purine biosynthesis protein ATIC - Bos taurus (Bovine) - ATIC gene Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. Indicus|evm.model.CM009492.1.569 P07589 FINC_BOVIN 99.919 0.999193 1.0004 FN1 - Fibronectin precursor - Bos taurus (Bovine) - FN1 gene Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Indicus|evm.model.CM009492.1.570 Q8N565 MREG_HUMAN 88.372 0.990741 1.00935 MREG - Melanoregulin - Homo sapiens (Human) - MREG gene Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity). Indicus|evm.model.CM009492.1.571 Q9BY49 PECR_HUMAN 77.409 0.980392 1.0099 PECR - Peroxisomal trans-2-enoyl-CoA reductase - Homo sapiens (Human) - PECR gene Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity. Indicus|evm.model.CM009492.1.572 Q2TBG9 TM169_BOVIN 98.990 0.848138 1.17508 TMEM169 - Transmembrane protein 169 - Bos taurus (Bovine) - TMEM169 gene Indicus|evm.model.CM009492.1.573 P27641 XRCC5_MOUSE 77.217 0.997093 0.939891 Xrcc5 - X-ray repair cross-complementing protein 5 - Mus musculus (Mouse) - Xrcc5 gene Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome. Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009492.1.574 Q9P2E8 MARH4_HUMAN 93.059 0.943902 1 MARCHF4 - E3 ubiquitin-protein ligase MARCHF4 precursor - Homo sapiens (Human) - MARCHF4 gene E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Indicus|evm.model.CM009492.1.576 Q9TTA5 SMAL1_BOVIN 94.444 0.993603 0.997872 SMARCAL1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 - Bos taurus (Bovine) - SMARCAL1 gene ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks (By similarity). Indicus|evm.model.CM009492.1.577 P61515 RL37P_RAT 100.000 0.978495 1.01087 Rpl37a-ps1 - Putative 60S ribosomal protein L37a - Rattus norvegicus (Rat) - Rpl37a-ps1 gene Indicus|evm.model.CM009492.1.578 P13384 IBP2_BOVIN 98.343 0.878049 0.646688 IGFBP2 - Insulin-like growth factor-binding protein 2 precursor - Bos taurus (Bovine) - IGFBP2 gene Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Indicus|evm.model.CM009492.1.579 Q05717 IBP5_BOVIN 99.631 0.992647 1.00369 IGFBP5 - Insulin-like growth factor-binding protein 5 precursor - Bos taurus (Bovine) - IGFBP5 gene IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Indicus|evm.model.CM009492.1.580 P17305 STP1_BOVIN 100.000 0.964286 1.01818 TNP1 - Spermatid nuclear transition protein 1 - Bos taurus (Bovine) - TNP1 gene Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Indicus|evm.model.CM009492.1.583 Q9GLM4 TENS1_BOVIN 98.612 0.931536 1.08163 TNS1 - Tensin-1 - Bos taurus (Bovine) - TNS1 gene Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. Indicus|evm.model.CM009492.1.585 Q28003 CXCR2_BOVIN 89.685 0.352227 2.74444 CXCR2 - C-X-C chemokine receptor type 2 - Bos taurus (Bovine) - CXCR2 gene Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). Indicus|evm.model.CM009492.1.586 Q28003 CXCR2_BOVIN 98.333 0.99446 1.00278 CXCR2 - C-X-C chemokine receptor type 2 - Bos taurus (Bovine) - CXCR2 gene Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). Indicus|evm.model.CM009492.1.587 Q3MHR7 ARPC2_BOVIN 100.000 0.993355 1.00333 ARPC2 - Actin-related protein 2/3 complex subunit 2 - Bos taurus (Bovine) - ARPC2 gene Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Indicus|evm.model.CM009492.1.588 Q862A9 GPBAR_BOVIN 100.000 0.993939 1.00304 GPBAR1 - G-protein coupled bile acid receptor 1 - Bos taurus (Bovine) - GPBAR1 gene Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). Indicus|evm.model.CM009492.1.589 Q3SZK1 AAMP_BOVIN 99.770 0.995413 1.00461 AAMP - Angio-associated migratory cell protein - Bos taurus (Bovine) - AAMP gene Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. Indicus|evm.model.CM009492.1.590 A7YY46 PNKD_BOVIN 80.198 0.699301 0.371429 PNKD - Probable hydrolase PNKD - Bos taurus (Bovine) - PNKD gene Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. Indicus|evm.model.CM009492.1.591 Q969X1 LFG3_HUMAN 85.209 0.993528 0.993569 TMBIM1 - Protein lifeguard 3 - Homo sapiens (Human) - TMBIM1 gene Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling. Indicus|evm.model.CM009492.1.592 A7YY46 PNKD_BOVIN 100.000 0.844875 0.937662 PNKD - Probable hydrolase PNKD - Bos taurus (Bovine) - PNKD gene Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. Indicus|evm.model.CM009492.1.593 Q7Z7H3 CATIP_HUMAN 79.156 0.984375 0.992248 CATIP - Ciliogenesis-associated TTC17-interacting protein - Homo sapiens (Human) - CATIP gene Plays a role in primary ciliogenesis by modulating actin polymerization. Indicus|evm.model.CM009492.1.594 Q27981 NRAM1_BOVIN 99.453 0.957968 1.04197 SLC11A1 - Natural resistance-associated macrophage protein 1 - Bos taurus (Bovine) - SLC11A1 gene Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (By similarity). Indicus|evm.model.CM009492.1.595 Q9GZU7 CTDS1_HUMAN 98.851 0.992366 1.00383 CTDSP1 - Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 - Homo sapiens (Human) - CTDSP1 gene Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Indicus|evm.model.CM009492.1.596 Q3SZP7 VILI_BOVIN 99.879 0.997585 1.00121 VIL1 - Villin-1 - Bos taurus (Bovine) - VIL1 gene Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity). Indicus|evm.model.CM009492.1.597 F1N5V1 UBP37_BOVIN 100.000 0.997963 1.00102 USP37 - Ubiquitin carboxyl-terminal hydrolase 37 - Bos taurus (Bovine) - USP37 gene Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1. Indicus|evm.model.CM009492.1.598 P21671 PLCD4_BOVIN 95.219 0.734244 1.20354 PLCD4 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 - Bos taurus (Bovine) - PLCD4 gene Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity). Indicus|evm.model.CM009492.1.599 P52746 ZN142_HUMAN 85.312 0.840217 1.09069 ZNF142 - Zinc finger protein 142 - Homo sapiens (Human) - ZNF142 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009492.1.600 Q5E9H5 BCS1_BOVIN 100.000 0.995238 1.00239 BCS1L - Mitochondrial chaperone BCS1 - Bos taurus (Bovine) - BCS1L gene Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity). Indicus|evm.model.CM009492.1.601 Q5E9N3 RNF25_BOVIN 99.564 0.995652 1.00437 RNF25 - E3 ubiquitin-protein ligase RNF25 - Bos taurus (Bovine) - RNF25 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2. Stimulates transcription mediated by NF-kappa-B. Indicus|evm.model.CM009492.1.602 Q9NRP7 STK36_HUMAN 88.280 0.99772 1.00076 STK36 - Serine/threonine-protein kinase 36 - Homo sapiens (Human) - STK36 gene Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia. Indicus|evm.model.CM009492.1.603 Q14679 TTLL4_HUMAN 81.266 0.995833 1.00083 TTLL4 - Tubulin polyglutamylase TTLL4 - Homo sapiens (Human) - TTLL4 gene Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase: generates monoglutamylation of CGAS, leading to impair the nucleotidyltransferase activity of CGAS. Indicus|evm.model.CM009492.1.604 P17177 CP27A_RABIT 78.652 0.988848 1.00561 CYP27A1 - Sterol 26-hydroxylase, mitochondrial precursor - Oryctolagus cuniculus (Rabbit) - CYP27A1 gene Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid (By similarity). Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways (PubMed:2722778). May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism. Plays a role in cholestanol metabolism in the cerebellum. Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation. Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium. May play a redundant role in vitamin D biosynthesis. Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (By similarity). Indicus|evm.model.CM009492.1.605 Q2LL38 AAKG3_BOVIN 98.592 0.995935 0.98994 PRKAG3 - 5'-AMP-activated protein kinase subunit gamma-3 - Bos taurus (Bovine) - PRKAG3 gene AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity). Indicus|evm.model.CM009492.1.606 Q9Y6F9 WNT6_HUMAN 97.808 0.994536 1.00274 WNT6 - Protein Wnt-6 precursor - Homo sapiens (Human) - WNT6 gene Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. Indicus|evm.model.CM009492.1.607 Q9GZT5 WN10A_HUMAN 95.444 0.995215 1.0024 WNT10A - Protein Wnt-10a precursor - Homo sapiens (Human) - WNT10A gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954). Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954). Required for normal hair follicle function (PubMed:28589954). Indicus|evm.model.CM009492.1.608 Q13319 CD5R2_HUMAN 82.306 0.994652 1.01907 CDK5R2 - Cyclin-dependent kinase 5 activator 2 precursor - Homo sapiens (Human) - CDK5R2 gene Activator of CDK5/TPKII. Indicus|evm.model.CM009492.1.609 O70132 FEV_RAT 99.029 0.476636 0.902954 Fev - Protein FEV - Rattus norvegicus (Rat) - Fev gene Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. Indicus|evm.model.CM009492.1.610 P26444 CRBA2_BOVIN 100.000 0.989899 1.00508 CRYBA2 - Beta-crystallin A2 - Bos taurus (Bovine) - CRYBA2 gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009492.1.612 Q3V0B4 CFA65_MOUSE 72.099 0.447208 0.979426 Cfap65 - Cilia- and flagella-associated protein 65 - Mus musculus (Mouse) - Cfap65 gene Plays a role in flagellar formation and sperm motility. Indicus|evm.model.CM009492.1.613 Q14623 IHH_HUMAN 96.602 0.995157 1.00487 IHH - Indian hedgehog protein precursor - Homo sapiens (Human) - IHH gene Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). Indicus|evm.model.CM009492.1.614 Q9H9Q4 NHEJ1_HUMAN 88.384 0.9801 0.672241 NHEJ1 - Non-homologous end-joining factor 1 - Homo sapiens (Human) - NHEJ1 gene DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17470781). Binds DNA in a length-dependent manner (PubMed:17317666). Indicus|evm.model.CM009492.1.615 Q6PIS1 S23A3_HUMAN 79.967 0.990148 0.998361 SLC23A3 - Solute carrier family 23 member 3 - Homo sapiens (Human) - SLC23A3 gene Indicus|evm.model.CM009492.1.616 Q5E9J2 CNPD1_BOVIN 99.757 0.995146 1.00243 CNPPD1 - Protein CNPPD1 - Bos taurus (Bovine) - CNPPD1 gene cyclin-dependent protein kinase holoenzyme complex, nucleus, cyclin-dependent protein serine/threonine kinase regulator activity, regulation of cyclin-dependent protein serine/threonine kinase activity Indicus|evm.model.CM009492.1.617 Q8NC44 RETR2_HUMAN 91.365 0.915129 0.998158 RETREG2 - Reticulophagy regulator 2 - Homo sapiens (Human) - RETREG2 gene integral component of membrane Indicus|evm.model.CM009492.1.618 Q4KLG9 ZFN2B_RAT 91.085 0.992278 1.00778 Zfand2b - AN1-type zinc finger protein 2B precursor - Rattus norvegicus (Rat) - Zfand2b gene Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Indicus|evm.model.CM009492.1.619 Q9NP58 ABCB6_HUMAN 89.180 0.995261 1.00238 ABCB6 - ATP-binding cassette sub-family B member 6 - Homo sapiens (Human) - ABCB6 gene ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:33007128, PubMed:27507172, PubMed:17661442, PubMed:23792964). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turns may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:17006453, PubMed:10837493, PubMed:23792964, PubMed:33007128). May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (PubMed:29940187). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (PubMed:25202056, PubMed:21266531, PubMed:31053883). In addition may play a role in the transition metal homeostasis (By similarity). Indicus|evm.model.CM009492.1.620 Q3T904 ATG9A_BOVIN 99.285 0.997611 0.997616 ATG9A - Autophagy-related protein 9A - Bos taurus (Bovine) - ATG9A gene Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). Indicus|evm.model.CM009492.1.621 Q58CQ5 ANKZ1_BOVIN 99.451 0.997257 1.00137 ANKZF1 - Ankyrin repeat and zinc finger domain-containing protein 1 - Bos taurus (Bovine) - ANKZF1 gene Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity). Indicus|evm.model.CM009492.1.622 Q6UWU2 GLB1L_HUMAN 86.392 0.964506 0.990826 GLB1L - Beta-galactosidase-1-like protein precursor - Homo sapiens (Human) - GLB1L gene Probable glycosyl hydrolase. Indicus|evm.model.CM009492.1.623 O75716 STK16_HUMAN 92.131 0.993464 1.00328 STK16 - Serine/threonine-protein kinase 16 - Homo sapiens (Human) - STK16 gene Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. Indicus|evm.model.CM009492.1.624 Q5XIF6 TBA4A_RAT 100.000 0.995392 0.96875 Tuba4a - Tubulin alpha-4A chain - Rattus norvegicus (Rat) - Tuba4a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Indicus|evm.model.CM009492.1.625 Q2HJ86 TBA1D_BOVIN 100.000 0.995585 1.00221 TUBA1D - Tubulin alpha-1D chain - Bos taurus (Bovine) - TUBA1D gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Indicus|evm.model.CM009492.1.626 P25686 DNJB2_HUMAN 95.636 0.982079 0.861111 DNAJB2 - DnaJ homolog subfamily B member 2 precursor - Homo sapiens (Human) - DNAJB2 gene Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). Indicus|evm.model.CM009492.1.627 P56722 PTPRN_BOVIN 99.796 0.997959 1.00102 PTPRN - Receptor-type tyrosine-protein phosphatase-like N precursor - Bos taurus (Bovine) - PTPRN gene Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. Seems to lack intrinsic enzyme activity. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization. Indicus|evm.model.CM009492.1.628 P10096 G3P_BOVIN 84.985 0.993506 0.924925 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Bos taurus (Bovine) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Indicus|evm.model.CM009492.1.629 A0JNL8 RES18_BOVIN 100.000 0.988571 1.00575 RESP18 - Regulated endocrine-specific protein 18 precursor - Bos taurus (Bovine) - RESP18 gene May play an important regulatory role in corticotrophs. Indicus|evm.model.CM009492.1.630 Q2HJH1 DNPEP_BOVIN 100.000 0.921569 1.0828 DNPEP - Aspartyl aminopeptidase - Bos taurus (Bovine) - DNPEP gene Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity). Indicus|evm.model.CM009492.1.631 O62654 DESM_BOVIN 100.000 0.995754 1.00213 DES - Desmin - Bos taurus (Bovine) - DES gene Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin. Indicus|evm.model.CM009492.1.632 Q15772 SPEG_HUMAN 91.740 0.999391 1.00459 SPEG - Striated muscle preferentially expressed protein kinase - Homo sapiens (Human) - SPEG gene Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Indicus|evm.model.CM009492.1.633 I3LUP1 GMPPA_PIG 96.905 0.995249 1.00238 GMPPA - Mannose-1-phosphate guanyltransferase alpha - Sus scrofa (Pig) - GMPPA gene May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. Indicus|evm.model.CM009492.1.634 Q7TNS7 ASIC4_MOUSE 98.330 0.804185 1.24119 Asic4 - Acid-sensing ion channel 4 - Mus musculus (Mouse) - Asic4 gene Probable cation channel with high affinity for sodium. Indicus|evm.model.CM009492.1.635 Q8IZ52 CHSS2_HUMAN 95.742 0.997423 1.00129 CHPF - Chondroitin sulfate synthase 2 - Homo sapiens (Human) - CHPF gene Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress. Indicus|evm.model.CM009492.1.636 Q08E36 TM198_BOVIN 100.000 0.99446 1.00278 TMEM198 - Transmembrane protein 198 - Bos taurus (Bovine) - TMEM198 gene Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity (By similarity). Indicus|evm.model.CM009492.1.637 O75147 OBSL1_HUMAN 90.981 0.99632 1.00316 OBSL1 - Obscurin-like protein 1 - Homo sapiens (Human) - OBSL1 gene Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. Indicus|evm.model.CM009492.1.638 P07994 INHA_BOVIN 100.000 0.99446 1.00278 INHA - Inhibin alpha chain precursor - Bos taurus (Bovine) - INHA gene Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Indicus|evm.model.CM009492.1.639 Q8N1F8 S11IP_HUMAN 77.941 0.998119 0.977022 STK11IP - Serine/threonine-protein kinase 11-interacting protein - Homo sapiens (Human) - STK11IP gene May regulate STK11/LKB1 function by controlling its subcellular localization. Indicus|evm.model.CM009492.1.640 P48751 B3A3_HUMAN 95.292 0.99837 0.995942 SLC4A3 - Anion exchange protein 3 - Homo sapiens (Human) - SLC4A3 gene Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-). Indicus|evm.model.CM009492.1.641 P00355 G3P_PIG 69.945 0.987805 0.492492 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Sus scrofa (Pig) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Indicus|evm.model.CM009492.1.642 P62907 RL10A_RAT 52.667 0.990566 0.488479 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Indicus|evm.model.CM009492.1.644 Q03137 EPHA4_MOUSE 98.841 0.973306 0.98783 Epha4 - Ephrin type-A receptor 4 precursor - Mus musculus (Mouse) - Epha4 gene Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (PubMed:30639848). Indicus|evm.model.CM009492.1.645 P23760 PAX3_HUMAN 98.921 0.94863 0.609603 PAX3 - Paired box protein Pax-3 - Homo sapiens (Human) - PAX3 gene Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087). Indicus|evm.model.CM009492.1.646 P24610 PAX3_MOUSE 98.980 0.902326 0.448852 Pax3 - Paired box protein Pax-3 - Mus musculus (Mouse) - Pax3 gene Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (By similarity). Indicus|evm.model.CM009492.1.649 Q9MYT8 ATP5I_PIG 57.143 0.973333 1.05634 ATP5ME - ATP synthase subunit e, mitochondrial - Sus scrofa (Pig) - ATP5ME gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Indicus|evm.model.CM009492.1.650 Q8IWX5 SGPP2_HUMAN 88.693 0.9925 1.00251 SGPP2 - Sphingosine-1-phosphate phosphatase 2 - Homo sapiens (Human) - SGPP2 gene Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (PubMed:17113265). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity). Indicus|evm.model.CM009492.1.651 Q9NSD9 SYFB_HUMAN 93.888 0.99661 1.0017 FARSB - Phenylalanine--tRNA ligase beta subunit - Homo sapiens (Human) - FARSB gene cytoplasm, cytosol, membrane, phenylalanine-tRNA ligase complex, phenylalanine-tRNA ligase activity, phenylalanyl-tRNA aminoacylation, protein heterotetramerization, translation, tRNA aminoacylation for protein translation Indicus|evm.model.CM009492.1.652 Q63060 GLPK_RAT 94.061 0.940433 1.05725 Gk - Glycerol kinase - Rattus norvegicus (Rat) - Gk gene Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. Indicus|evm.model.CM009492.1.653 Q70VZ7 MOGT1_BOVIN 99.403 0.994048 1.00299 MOGAT1 - 2-acylglycerol O-acyltransferase 1 - Bos taurus (Bovine) - MOGAT1 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine. Indicus|evm.model.CM009492.1.654 Q5E995 RS6_BOVIN 99.197 0.992 1.00402 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009492.1.655 O95573 ACSL3_HUMAN 95.278 0.997226 1.00139 ACSL3 - Long-chain-fatty-acid--CoA ligase 3 - Homo sapiens (Human) - ACSL3 gene Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). Indicus|evm.model.CM009492.1.656 Q8WWG9 KCNE4_HUMAN 87.647 0.988166 0.764706 KCNE4 - Potassium voltage-gated channel subfamily E member 4 - Homo sapiens (Human) - KCNE4 gene Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current. Indicus|evm.model.CM009492.1.657 P20616 SCG2_BOVIN 99.674 0.996743 1.00163 SCG2 - Secretogranin-2 precursor - Bos taurus (Bovine) - SCG2 gene Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. Indicus|evm.model.CM009492.1.658 Q96PC3 AP1S3_HUMAN 96.528 0.922581 1.00649 AP1S3 - AP-1 complex subunit sigma-3 - Homo sapiens (Human) - AP1S3 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904). Indicus|evm.model.CM009492.1.659 Q2KIY3 WDFY1_BOVIN 100.000 0.870536 1.09268 WDFY1 - WD repeat and FYVE domain-containing protein 1 - Bos taurus (Bovine) - WDFY1 gene Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. Indicus|evm.model.CM009492.1.660 Q2KIS2 RM44_BOVIN 99.398 0.993994 1.00301 MRPL44 - 39S ribosomal protein L44, mitochondrial precursor - Bos taurus (Bovine) - MRPL44 gene Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. Indicus|evm.model.CM009492.1.661 P07093 GDN_HUMAN 93.617 0.723602 0.809045 SERPINE2 - Glia-derived nexin precursor - Homo sapiens (Human) - SERPINE2 gene Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. Indicus|evm.model.CM009492.1.662 A6QLD5 F124B_BOVIN 96.649 0.891705 0.941432 FAM124B - Protein FAM124B - Bos taurus (Bovine) - FAM124B gene nucleoplasm Indicus|evm.model.CM009492.1.663 B5DF89 CUL3_RAT 99.866 0.997323 0.972656 Cul3 - Cullin-3 - Rattus norvegicus (Rat) - Cul3 gene Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4. The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (By similarity). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (By similarity). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (By similarity). As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions mediates 'Lys-48' ubiquitination and proteasomal degradation of TIAM1. By controlling the ubiquitination of that RAC1 guanine exchange factors (GEF), regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (By similarity). Indicus|evm.model.CM009492.1.664 A0A1B0GUA6 CC195_HUMAN 64.423 0.990196 1.01493 CCDC195 - Putative coiled-coil domain-containing protein 195 - Homo sapiens (Human) - CCDC195 gene Indicus|evm.model.CM009492.1.665 Q96BY6 DOC10_HUMAN 94.685 0.974545 1.0064 DOCK10 - Dedicator of cytokinesis protein 10 - Homo sapiens (Human) - DOCK10 gene Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. Indicus|evm.model.CM009492.1.666 Q9P242 NYAP2_HUMAN 93.488 0.800747 1.22971 NYAP2 - Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 - Homo sapiens (Human) - NYAP2 gene Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. Indicus|evm.model.CM009492.1.668 P35568 IRS1_HUMAN 90.354 0.998384 0.996779 IRS1 - Insulin receptor substrate 1 - Homo sapiens (Human) - IRS1 gene May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). Indicus|evm.model.CM009492.1.669 P49666 RL21_PIG 71.687 0.987952 1.0375 RPL21 - 60S ribosomal protein L21 - Sus scrofa (Pig) - RPL21 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009492.1.670 Q8TEB9 RHBL4_HUMAN 83.544 0.975232 1.0254 RHBDD1 - Rhomboid-related protein 4 - Homo sapiens (Human) - RHBDD1 gene Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia. Indicus|evm.model.CM009492.1.671 Q29442 CO4A4_BOVIN 100.000 0.261568 3.43488 COL4A4 - Collagen alpha-4(IV) chain - Bos taurus (Bovine) - COL4A4 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Indicus|evm.model.CM009492.1.672 Q28084 CO4A3_BOVIN 98.514 0.299363 3.33333 COL4A3 - Collagen alpha-3(IV) chain - Bos taurus (Bovine) - COL4A3 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Indicus|evm.model.CM009492.1.673 Q3ZCD8 MFF_BOVIN 100.000 0.220126 1.45872 MFF - Mitochondrial fission factor - Bos taurus (Bovine) - MFF gene Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. Indicus|evm.model.CM009492.1.674 Q3T0Z4 T4S20_BOVIN 99.565 0.66185 1.50435 TM4SF20 - Transmembrane 4 L6 family member 20 - Bos taurus (Bovine) - TM4SF20 gene Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. Indicus|evm.model.CM009492.1.675 Q2TA45 AGFG1_BOVIN 100.000 0.996169 0.928826 AGFG1 - Arf-GAP domain and FG repeat-containing protein 1 - Bos taurus (Bovine) - AGFG1 gene Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization (By similarity). Indicus|evm.model.CM009492.1.678 Q4R877 S19A3_MACFA 80.285 0.993827 0.979839 SLC19A3 - Thiamine transporter 2 - Macaca fascicularis (Crab-eating macaque) - SLC19A3 gene Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity (By similarity). Indicus|evm.model.CM009492.1.679 Q3ZBZ8 STIP1_BOVIN 99.263 0.996324 1.00184 STIP1 - Stress-induced-phosphoprotein 1 - Bos taurus (Bovine) - STIP1 gene Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Indicus|evm.model.CM009492.1.681 Q8SQB1 CCL20_BOVIN 97.938 0.979592 1.02083 CCL20 - C-C motif chemokine 20 precursor - Bos taurus (Bovine) - CCL20 gene Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Indicus|evm.model.CM009492.1.682 Q0P593 DAW1_BOVIN 99.012 0.881579 1.0988 DAW1 - Dynein assembly factor with WDR repeat domains 1 - Bos taurus (Bovine) - DAW1 gene May play a role in axonemal outer row dynein assembly. Indicus|evm.model.CM009492.1.683 Q2M3C7 SPKAP_HUMAN 75.467 0.998829 1.00471 SPHKAP - A-kinase anchor protein SPHKAP - Homo sapiens (Human) - SPHKAP gene Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. Indicus|evm.model.CM009492.1.684 Q5R9W4 OSBL9_PONAB 84.444 0.917808 0.19837 OSBPL9 - Oxysterol-binding protein-related protein 9 - Pongo abelii (Sumatran orangutan) - OSBPL9 gene Indicus|evm.model.CM009492.1.685 Q8IYB1 M21D2_HUMAN 74.739 0.924312 0.887984 MB21D2 - Protein MB21D2 - Homo sapiens (Human) - MB21D2 gene cadherin binding, protein-containing complex binding Indicus|evm.model.CM009492.1.686 Q4KLH6 CE162_RAT 80.682 0.913043 0.0655738 Cep162 - Centrosomal protein of 162 kDa - Rattus norvegicus (Rat) - Cep162 gene Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity). Indicus|evm.model.CM009492.1.687 Q3UBG2 PCLI1_MOUSE 98.113 0.918605 0.792627 Pid1 - PTB-containing, cubilin and LRP1-interacting protein - Mus musculus (Mouse) - Pid1 gene Increases proliferation of preadipocytes without affecting adipocytic differentiation. Indicus|evm.model.CM009492.1.688 Q8NFT8 DNER_HUMAN 88.331 0.997253 0.987788 DNER - Delta and Notch-like epidermal growth factor-related receptor precursor - Homo sapiens (Human) - DNER gene Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). Indicus|evm.model.CM009492.1.690 E1B7Q7 TRIPC_BOVIN 98.370 0.999013 1.01707 TRIP12 - E3 ubiquitin-protein ligase TRIP12 - Bos taurus (Bovine) - TRIP12 gene E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex. Indicus|evm.model.CM009492.1.691 Q5R796 FBX36_PONAB 82.581 0.980892 0.835106 FBXO36 - F-box only protein 36 - Pongo abelii (Sumatran orangutan) - FBXO36 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009492.1.692 Q7RTX9 MOT14_HUMAN 88.672 0.996101 1.00588 SLC16A14 - Monocarboxylate transporter 14 - Homo sapiens (Human) - SLC16A14 gene Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Indicus|evm.model.CM009492.1.693 Q9H930 SP14L_HUMAN 65.012 0.525692 1.30862 SP140L - Nuclear body protein SP140-like protein - Homo sapiens (Human) - SP140L gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009492.1.694 Q9H930 SP14L_HUMAN 52.083 0.238693 0.686207 SP140L - Nuclear body protein SP140-like protein - Homo sapiens (Human) - SP140L gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009492.1.695 Q9H930 SP14L_HUMAN 59.429 0.34279 0.72931 SP140L - Nuclear body protein SP140-like protein - Homo sapiens (Human) - SP140L gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009492.1.697 Q9Y376 CAB39_HUMAN 100.000 0.934066 1.06745 CAB39 - Calcium-binding protein 39 - Homo sapiens (Human) - CAB39 gene Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. Indicus|evm.model.CM009492.1.698 A2VDN0 ITM2C_BOVIN 100.000 0.992647 1.00369 ITM2C - Integral membrane protein 2C - Bos taurus (Bovine) - ITM2C gene Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). Indicus|evm.model.CM009492.1.699 Q9Y2T6 GPR55_HUMAN 79.439 0.916905 1.09404 GPR55 - G-protein coupled receptor 55 - Homo sapiens (Human) - GPR55 gene May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. Indicus|evm.model.CM009492.1.701 Q9D9T6 SPTA3_MOUSE 74.227 0.413043 1.19171 Spata3 - Spermatogenesis-associated protein 3 - Mus musculus (Mouse) - Spata3 gene Indicus|evm.model.CM009492.1.702 A6NCS6 CB072_HUMAN 74.237 0.992908 0.955932 C2orf72 - Uncharacterized protein C2orf72 - Homo sapiens (Human) - C2orf72 gene Indicus|evm.model.CM009492.1.703 Q5R5S4 PSMD1_PONAB 98.885 0.99682 0.660021 PSMD1 - 26S proteasome non-ATPase regulatory subunit 1 - Pongo abelii (Sumatran orangutan) - PSMD1 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Indicus|evm.model.CM009492.1.704 P41595 5HT2B_HUMAN 88.773 0.888683 1.12058 HTR2B - 5-hydroxytryptamine receptor 2B - Homo sapiens (Human) - HTR2B gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538). Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity). Indicus|evm.model.CM009492.1.705 Q3TXS7 PSMD1_MOUSE 97.892 0.993994 0.349423 Psmd1 - 26S proteasome non-ATPase regulatory subunit 1 - Mus musculus (Mouse) - Psmd1 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Indicus|evm.model.CM009492.1.706 Q2KI89 ARMC9_BOVIN 100.000 0.810745 1.23158 ARMC9 - LisH domain-containing protein ARMC9 - Bos taurus (Bovine) - ARMC9 gene Acts as a positive regulator of hedgehog (Hh) signaling (By similarity). Involved in ciliogenesis (By similarity). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity). Indicus|evm.model.CM009492.1.707 Q8NFL0 B3GN7_HUMAN 84.131 0.965854 1.02244 B3GNT7 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 - Homo sapiens (Human) - B3GNT7 gene May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues. Indicus|evm.model.CM009492.1.708 Q99873 ANM1_HUMAN 50.479 0.988636 0.71159 PRMT1 - Protein arginine N-methyltransferase 1 - Homo sapiens (Human) - PRMT1 gene Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:10749851, PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Indicus|evm.model.CM009492.1.709 P19338 NUCL_HUMAN 92.170 0.617729 1.0169 NCL - Nucleolin - Homo sapiens (Human) - NCL gene Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Indicus|evm.model.CM009492.1.710 Q9HB89 NMUR1_HUMAN 76.636 0.995283 0.995305 NMUR1 - Neuromedin-U receptor 1 - Homo sapiens (Human) - NMUR1 gene Receptor for the neuromedin-U and neuromedin-S neuropeptides. Indicus|evm.model.CM009492.1.711 Q53QW1 TEX44_HUMAN 48.257 0.940341 0.891139 TEX44 - Testis-expressed protein 44 - Homo sapiens (Human) - TEX44 gene cytoplasm Indicus|evm.model.CM009492.1.714 P01252 PTMA_BOVIN 100.000 0.981982 1.00909 PTMA - Prothymosin alpha - Bos taurus (Bovine) - PTMA gene Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Indicus|evm.model.CM009492.1.715 Q95142 PDE6D_BOVIN 100.000 0.986755 1.00667 PDE6D - Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta - Bos taurus (Bovine) - PDE6D gene Promotes the release of prenylated target proteins from cellular membranes (PubMed:8798640). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). Indicus|evm.model.CM009492.1.716 Q2KI56 CSN7B_BOVIN 100.000 0.992453 1.00379 COPS7B - COP9 signalosome complex subunit 7b - Bos taurus (Bovine) - COPS7B gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Indicus|evm.model.CM009492.1.719 P62752 RL23A_RAT 72.581 0.304348 1.17949 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009492.1.720 P55206 ANFC_BOVIN 100.000 0.984252 1.00794 NPPC - C-type natriuretic peptide precursor - Bos taurus (Bovine) - NPPC gene Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3 (By similarity). Indicus|evm.model.CM009492.1.721 Q8IYB7 DI3L2_HUMAN 90.235 0.998192 0.624859 DIS3L2 - DIS3-like exonuclease 2 - Homo sapiens (Human) - DIS3L2 gene 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. Indicus|evm.model.CM009492.1.722 P19111 PPBI_BOVIN 75.985 0.995772 0.88743 ALPI - Intestinal-type alkaline phosphatase precursor - Bos taurus (Bovine) - ALPI gene plasma membrane, alkaline phosphatase activity, magnesium ion binding, zinc ion binding, dephosphorylation Indicus|evm.model.CM009492.1.723 P19111 PPBI_BOVIN 80.337 0.996241 0.998124 ALPI - Intestinal-type alkaline phosphatase precursor - Bos taurus (Bovine) - ALPI gene plasma membrane, alkaline phosphatase activity, magnesium ion binding, zinc ion binding, dephosphorylation Indicus|evm.model.CM009492.1.724 P09923 PPBI_HUMAN 61.323 0.905192 0.839015 ALPI - Intestinal-type alkaline phosphatase precursor - Homo sapiens (Human) - ALPI gene extracellular region, plasma membrane, alkaline phosphatase activity, magnesium ion binding, protease binding, zinc ion binding, dephosphorylation, digestion, phosphatidic acid biosynthetic process Indicus|evm.model.CM009492.1.725 P19111 PPBI_BOVIN 81.273 0.996219 0.992495 ALPI - Intestinal-type alkaline phosphatase precursor - Bos taurus (Bovine) - ALPI gene plasma membrane, alkaline phosphatase activity, magnesium ion binding, zinc ion binding, dephosphorylation Indicus|evm.model.CM009492.1.726 P19111 PPBI_BOVIN 92.871 0.996234 0.996248 ALPI - Intestinal-type alkaline phosphatase precursor - Bos taurus (Bovine) - ALPI gene plasma membrane, alkaline phosphatase activity, magnesium ion binding, zinc ion binding, dephosphorylation Indicus|evm.model.CM009492.1.727 P19111 PPBI_BOVIN 94.559 0.996234 0.996248 ALPI - Intestinal-type alkaline phosphatase precursor - Bos taurus (Bovine) - ALPI gene plasma membrane, alkaline phosphatase activity, magnesium ion binding, zinc ion binding, dephosphorylation Indicus|evm.model.CM009492.1.728 O95672 ECEL1_HUMAN 95.871 0.997423 1.00129 ECEL1 - Endothelin-converting enzyme-like 1 - Homo sapiens (Human) - ECEL1 gene May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. Indicus|evm.model.CM009492.1.731 P04759 ACHD_BOVIN 100.000 0.475531 2.09884 CHRND - Acetylcholine receptor subunit delta precursor - Bos taurus (Bovine) - CHRND gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Indicus|evm.model.CM009492.1.732 P13536 ACHG_BOVIN 100.000 0.996154 1.00193 CHRNG - Acetylcholine receptor subunit gamma precursor - Bos taurus (Bovine) - CHRNG gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Indicus|evm.model.CM009492.1.733 O60573 IF4E2_HUMAN 99.550 0.932489 0.967347 EIF4E2 - Eukaryotic translation initiation factor 4E type 2 - Homo sapiens (Human) - EIF4E2 gene Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:17368478, PubMed:25624349, PubMed:9582349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484). Indicus|evm.model.CM009492.1.734 O60928 KCJ13_HUMAN 90.741 0.346405 0.425 KCNJ13 - Inward rectifier potassium channel 13 - Homo sapiens (Human) - KCNJ13 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. Indicus|evm.model.CM009492.1.735 B2RTY4 MYO9A_HUMAN 98.795 0.609337 0.159733 MYO9A - Unconventional myosin-IXa - Homo sapiens (Human) - MYO9A gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). Indicus|evm.model.CM009492.1.736 Q8IXK0 PHC2_HUMAN 90.739 0.798493 1.23776 PHC2 - Polyhomeotic-like protein 2 - Homo sapiens (Human) - PHC2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Indicus|evm.model.CM009492.1.737 Q5T0B9 ZN362_HUMAN 97.789 0.99505 0.961905 ZNF362 - Zinc finger protein 362 - Homo sapiens (Human) - ZNF362 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009492.1.738 Q80V85 TRI62_MOUSE 99.579 0.995798 1.00211 Trim62 - E3 ubiquitin-protein ligase TRIM62 - Mus musculus (Mouse) - Trim62 gene E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (By similarity). Indicus|evm.model.CM009492.1.740 Q96A70 AZIN2_HUMAN 73.233 0.99537 0.93913 AZIN2 - Antizyme inhibitor 2 - Homo sapiens (Human) - AZIN2 gene Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728). Indicus|evm.model.CM009492.1.741 P08166 KAD2_BOVIN 100.000 0.991736 1.00415 AK2 - Adenylate kinase 2, mitochondrial - Bos taurus (Bovine) - AK2 gene Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. Indicus|evm.model.CM009492.1.742 Q6ZMZ0 RN19B_HUMAN 96.661 0.82959 1.03415 RNF19B - E3 ubiquitin-protein ligase RNF19B - Homo sapiens (Human) - RNF19B gene E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036). Indicus|evm.model.CM009492.1.743 Q3ZCD2 TMM54_BOVIN 99.550 0.991031 1.0045 TMEM54 - Transmembrane protein 54 - Bos taurus (Bovine) - TMEM54 gene Indicus|evm.model.CM009492.1.744 P84076 HPCA_RAT 100.000 0.989691 1.00518 Hpca - Neuron-specific calcium-binding protein hippocalcin - Rattus norvegicus (Rat) - Hpca gene Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (By similarity). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (PubMed:15336960). Indicus|evm.model.CM009492.1.745 Q8NAU1 FNDC5_HUMAN 99.448 0.841121 1.00943 FNDC5 - Fibronectin type III domain-containing protein 5 precursor - Homo sapiens (Human) - FNDC5 gene Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. Indicus|evm.model.CM009492.1.746 Q3MHH3 S1PBP_BOVIN 99.763 0.995272 1.00237 S100PBP - S100P-binding protein - Bos taurus (Bovine) - S100PBP gene cytosol, nucleus, calcium-dependent protein binding Indicus|evm.model.CM009492.1.747 Q29465 SYYC_BOVIN 99.242 0.996219 1.00189 YARS1 - Tyrosine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - YARS1 gene Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Indicus|evm.model.CM009492.1.748 Q9P206 K1522_HUMAN 82.051 0.968932 0.995169 KIAA1522 - Uncharacterized protein KIAA1522 - Homo sapiens (Human) - KIAA1522 gene cell differentiation Indicus|evm.model.CM009492.1.750 Q9H7C4 SYNCI_HUMAN 80.124 0.995833 0.995851 SYNC - Syncoilin - Homo sapiens (Human) - SYNC gene Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. Indicus|evm.model.CM009492.1.751 Q60972 RBBP4_MOUSE 100.000 0.995305 1.00235 Rbbp4 - Histone-binding protein RBBP4 - Mus musculus (Mouse) - Rbbp4 gene Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Indicus|evm.model.CM009492.1.752 Q2YDE7 ARCH_BOVIN 100.000 0.988095 1.00599 ZBTB8OS - Protein archease - Bos taurus (Bovine) - ZBTB8OS gene Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (By similarity). Indicus|evm.model.CM009492.1.753 Q0VCJ6 ZBT8A_BOVIN 99.773 0.995475 1.00227 ZBTB8A - Zinc finger and BTB domain-containing protein 8A - Bos taurus (Bovine) - ZBTB8A gene May be involved in transcriptional regulation. Indicus|evm.model.CM009492.1.754 Q8NAP8 ZBT8B_HUMAN 92.683 0.958824 0.343434 ZBTB8B - Zinc finger and BTB domain-containing protein 8B - Homo sapiens (Human) - ZBTB8B gene May be involved in transcriptional regulation. Indicus|evm.model.CM009492.1.755 Q8NAP8 ZBT8B_HUMAN 78.947 0.861183 0.785859 ZBTB8B - Zinc finger and BTB domain-containing protein 8B - Homo sapiens (Human) - ZBTB8B gene May be involved in transcriptional regulation. Indicus|evm.model.CM009492.1.756 Q3SX22 BSDC1_BOVIN 100.000 0.986079 0.934924 BSDC1 - BSD domain-containing protein 1 - Bos taurus (Bovine) - BSDC1 gene Indicus|evm.model.CM009492.1.757 Q9D2E1 TSSK3_MOUSE 98.134 0.988889 1.00746 Tssk3 - Testis-specific serine/threonine-protein kinase 3 - Mus musculus (Mouse) - Tssk3 gene May be involved in a signaling pathway during male germ cell development or mature sperm function. Indicus|evm.model.CM009492.1.758 B2KGE5 F229A_MOUSE 90.625 0.984496 1.00781 Fam229a - Protein FAM229A - Mus musculus (Mouse) - Fam229a gene Indicus|evm.model.CM009492.1.759 Q0VBZ9 MRP_BOVIN 100.000 0.853535 1 MARCKSL1 - MARCKS-related protein - Bos taurus (Bovine) - MARCKSL1 gene Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. Indicus|evm.model.CM009492.1.760 Q32PJ8 HDAC1_BOVIN 100.000 0.995859 1.00207 HDAC1 - Histone deacetylase 1 - Bos taurus (Bovine) - HDAC1 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. Indicus|evm.model.CM009492.1.761 P06239 LCK_HUMAN 96.267 0.996078 1.00196 LCK - Tyrosine-protein kinase Lck - Homo sapiens (Human) - LCK gene Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). Indicus|evm.model.CM009492.1.762 Q9BTA0 F167B_HUMAN 88.957 0.98773 1 FAM167B - Protein FAM167B - Homo sapiens (Human) - FAM167B gene Indicus|evm.model.CM009492.1.763 Q2KJ24 MTM9L_BOVIN 100.000 0.996324 1.00184 MTMR9L - Myotubularin-related protein 9-like - Bos taurus (Bovine) - MTMR9L gene Probable pseudophosphatase. Indicus|evm.model.CM009492.1.764 Q5E966 EIF3I_BOVIN 100.000 0.993865 1.00308 EIF3I - Eukaryotic translation initiation factor 3 subunit I - Bos taurus (Bovine) - EIF3I gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Indicus|evm.model.CM009492.1.765 A7YW81 TM234_BOVIN 100.000 0.985816 1.00714 TMEM234 - Transmembrane protein 234 - Bos taurus (Bovine) - TMEM234 gene Indicus|evm.model.CM009492.1.766 A2VCK2 DCD2B_HUMAN 81.737 0.97076 0.979943 DCDC2B - Doublecortin domain-containing protein 2B - Homo sapiens (Human) - DCDC2B gene microtubule, microtubule organizing center Indicus|evm.model.CM009492.1.767 Q2TBI7 IQCC_BOVIN 98.291 0.995736 1.00214 IQCC - IQ domain-containing protein C - Bos taurus (Bovine) - IQCC gene Indicus|evm.model.CM009492.1.768 Q8CEG5 CC28B_MOUSE 95.000 0.805668 1.235 Ccdc28b - Coiled-coil domain-containing protein 28B - Mus musculus (Mouse) - Ccdc28b gene Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex. Indicus|evm.model.CM009492.1.769 P62907 RL10A_RAT 97.235 0.990826 1.00461 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Indicus|evm.model.CM009492.1.770 Q17QW2 TM39B_BOVIN 99.119 0.854717 1.07724 TMEM39B - Transmembrane protein 39B - Bos taurus (Bovine) - TMEM39B gene membrane Indicus|evm.model.CM009492.1.771 Q07666 KHDR1_HUMAN 99.538 0.995392 0.979684 KHDRBS1 - KH domain-containing, RNA-binding, signal transduction-associated protein 1 - Homo sapiens (Human) - KHDRBS1 gene Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). Indicus|evm.model.CM009492.1.772 Q6AXS9 RFLB_RAT 66.279 0.653846 0.601852 Rflnb - Refilin-B - Rattus norvegicus (Rat) - Rflnb gene Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. Indicus|evm.model.CM009492.1.773 Q3ZCJ7 TBA1C_BOVIN 99.555 0.995556 1.00223 TUBA1C - Tubulin alpha-1C chain - Bos taurus (Bovine) - TUBA1C gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Indicus|evm.model.CM009492.1.774 Q6P9X4 TP4A2_RAT 100.000 0.988095 1.00599 Ptp4a2 - Protein tyrosine phosphatase type IVA 2 precursor - Rattus norvegicus (Rat) - Ptp4a2 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity). Indicus|evm.model.CM009492.1.775 Q6ZMY3 SPOC1_HUMAN 54.408 0.861524 0.884868 SPOCD1 - SPOC domain-containing protein 1 - Homo sapiens (Human) - SPOCD1 gene Essential excecutor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (By similarity). Associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (By similarity). Tethering of PIWIL4 to a nascent transposable element transcript recruits repressive chromatin remodeling activities and the de novo methylation apparatus through SPOCD1 (By similarity). Not required for piRNA biosynthesis (By similarity). Indicus|evm.model.CM009492.1.776 Q5R7Y0 AGRB2_PONAB 95.886 0.71099 1.10909 ADGRB2 - Adhesion G protein-coupled receptor B2 precursor - Pongo abelii (Sumatran orangutan) - ADGRB2 gene Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity). Indicus|evm.model.CM009492.1.777 Q8BLX7 COGA1_MOUSE 86.398 0.998759 1.01962 Col16a1 - Collagen alpha-1(XVI) chain precursor - Mus musculus (Mouse) - Col16a1 gene Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology. Indicus|evm.model.CM009492.1.778 Q641Z8 PEF1_RAT 87.879 0.684028 1.01767 Pef1 - Peflin - Rattus norvegicus (Rat) - Pef1 gene Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (By similarity). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (PubMed:27276012). Indicus|evm.model.CM009492.1.779 Q0GBZ5 OX1R_BOVIN 99.529 0.995305 1.00235 HCRTR1 - Orexin receptor type 1 - Bos taurus (Bovine) - HCRTR1 gene Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Indicus|evm.model.CM009492.1.780 Q9GZM7 TINAL_HUMAN 90.828 0.948936 1.00642 TINAGL1 - Tubulointerstitial nephritis antigen-like precursor - Homo sapiens (Human) - TINAGL1 gene May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity). Indicus|evm.model.CM009492.1.781 P10790 FABPH_BOVIN 100.000 0.985075 1.00752 FABP3 - Fatty acid-binding protein, heart - Bos taurus (Bovine) - FABP3 gene FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Indicus|evm.model.CM009492.1.782 Q9NP64 NO40_HUMAN 99.170 0.851064 1.17012 ZCCHC17 - Nucleolar protein of 40 kDa - Homo sapiens (Human) - ZCCHC17 gene identical protein binding, RNA binding, RNA stabilization Indicus|evm.model.CM009492.1.783 Q2HJH6 SNR40_BOVIN 99.721 0.994429 1.00279 SNRNP40 - U5 small nuclear ribonucleoprotein 40 kDa protein - Bos taurus (Bovine) - SNRNP40 gene Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. Indicus|evm.model.CM009492.1.784 Q4KMZ8 NKAI1_HUMAN 100.000 0.979167 0.927536 NKAIN1 - Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 precursor - Homo sapiens (Human) - NKAIN1 gene regulation of sodium ion transport Indicus|evm.model.CM009492.1.786 Q14671 PUM1_HUMAN 99.578 0.998315 1.00084 PUM1 - Pumilio homolog 1 - Homo sapiens (Human) - PUM1 gene Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:21572425, PubMed:18328718, PubMed:21653694, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). Indicus|evm.model.CM009492.1.787 O75056 SDC3_HUMAN 92.405 0.778656 1.1448 SDC3 - Syndecan-3 - Homo sapiens (Human) - SDC3 gene Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Indicus|evm.model.CM009492.1.789 Q2KJA5 LAPM5_BOVIN 100.000 0.992453 1.00379 LAPTM5 - Lysosomal-associated transmembrane protein 5 - Bos taurus (Bovine) - LAPTM5 gene May have a special functional role during embryogenesis and in adult hematopoietic cells. Indicus|evm.model.CM009492.1.790 P21941 MATN1_HUMAN 94.956 0.834862 1.09879 MATN1 - Cartilage matrix protein precursor - Homo sapiens (Human) - MATN1 gene Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen. Indicus|evm.model.CM009492.1.793 B1AUH1 PTPRU_MOUSE 85.185 0.347518 0.0975104 Ptpru - Receptor-type tyrosine-protein phosphatase U precursor - Mus musculus (Mouse) - Ptpru gene Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis (By similarity). Indicus|evm.model.CM009492.1.794 Q92729 PTPRU_HUMAN 87.500 0.321429 0.135546 PTPRU - Receptor-type tyrosine-protein phosphatase U precursor - Homo sapiens (Human) - PTPRU gene Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. Indicus|evm.model.CM009492.1.795 Q92729 PTPRU_HUMAN 95.819 0.962813 1.02282 PTPRU - Receptor-type tyrosine-protein phosphatase U precursor - Homo sapiens (Human) - PTPRU gene Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. Indicus|evm.model.CM009492.1.796 Q7YS70 MECR_BOVIN 93.158 0.994751 1.02145 MECR - Enoyl-[acyl-carrier-protein] reductase, mitochondrial precursor - Bos taurus (Bovine) - MECR gene Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II) (PubMed:12654921). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (By similarity). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (By similarity). Indicus|evm.model.CM009492.1.797 Q8VE97 SRSF4_MOUSE 95.724 0.611336 1.01022 Srsf4 - Serine/arginine-rich splicing factor 4 - Mus musculus (Mouse) - Srsf4 gene Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 (By similarity). Indicus|evm.model.CM009492.1.798 Q69YZ2 T200B_HUMAN 95.161 0.989305 0.609121 TMEM200B - Transmembrane protein 200B - Homo sapiens (Human) - TMEM200B gene Indicus|evm.model.CM009492.1.799 Q9N179 EPB41_BOVIN 92.744 0.433263 1.52998 EPB41 - Protein 4.1 - Bos taurus (Bovine) - EPB41 gene Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. Indicus|evm.model.CM009492.1.800 P41143 OPRD_HUMAN 96.624 0.897338 0.706989 OPRD1 - Delta-type opioid receptor - Homo sapiens (Human) - OPRD1 gene G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. Indicus|evm.model.CM009492.1.801 P41143 OPRD_HUMAN 89.474 0.630252 0.319892 OPRD1 - Delta-type opioid receptor - Homo sapiens (Human) - OPRD1 gene G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. Indicus|evm.model.CM009492.1.802 Q0VCZ3 YTHD2_BOVIN 100.000 0.996558 1.00172 YTHDF2 - YTH domain-containing family protein 2 - Bos taurus (Bovine) - YTHDF2 gene Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex. Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (By similarity). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development. Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (By similarity). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (By similarity). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation. Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts. Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation. May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation. Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation. The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules. May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing (By similarity). Indicus|evm.model.CM009492.1.803 Q2HJ87 GMEB1_BOVIN 99.822 0.996454 1.00178 GMEB1 - Glucocorticoid modulatory element-binding protein 1 - Bos taurus (Bovine) - GMEB1 gene Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity). Indicus|evm.model.CM009492.1.804 Q3T174 TAF12_BOVIN 99.379 0.747664 1.32919 TAF12 - Transcription initiation factor TFIID subunit 12 - Bos taurus (Bovine) - TAF12 gene TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription (By similarity). Indicus|evm.model.CM009492.1.805 Q8N4Z0 RAB42_HUMAN 80.000 0.99095 1.01376 RAB42 - Ras-related protein Rab-42 - Homo sapiens (Human) - RAB42 gene plasma membrane, GDP binding, GTP binding, GTPase activity, Ras protein signal transduction Indicus|evm.model.CM009492.1.806 Q1RMJ7 TSAP1_BOVIN 100.000 0.993056 1.00348 TRNAU1AP - tRNA selenocysteine 1-associated protein 1 - Bos taurus (Bovine) - TRNAU1AP gene Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity). Indicus|evm.model.CM009492.1.807 P18754 RCC1_HUMAN 95.487 0.992908 1.00475 RCC1 - Regulator of chromosome condensation - Homo sapiens (Human) - RCC1 gene Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:1944575, PubMed:17435751, PubMed:20668449, PubMed:22215983, PubMed:11336674). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). Indicus|evm.model.CM009492.1.808 F1MCY2 PHAR4_BOVIN 99.286 0.99431 0.98736 PHACTR4 - Phosphatase and actin regulator 4 - Bos taurus (Bovine) - PHACTR4 gene Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). Indicus|evm.model.CM009492.1.809 Q2HJI3 F136A_BOVIN 96.377 0.925676 1.07246 FAM136A - Protein FAM136A - Bos taurus (Bovine) - FAM136A gene cytoplasm Indicus|evm.model.CM009492.1.810 P62752 RL23A_RAT 69.565 0.762712 0.378205 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009492.1.811 Q02543 RL18A_HUMAN 79.545 0.987179 0.886364 RPL18A - 60S ribosomal protein L18a - Homo sapiens (Human) - RPL18A gene cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing Indicus|evm.model.CM009492.1.812 Q0VCD4 MED18_BOVIN 100.000 0.990431 1.00481 MED18 - Mediator of RNA polymerase II transcription subunit 18 - Bos taurus (Bovine) - MED18 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009492.1.814 Q96JM2 ZN462_HUMAN 90.722 0.914286 0.0418994 ZNF462 - Zinc finger protein 462 - Homo sapiens (Human) - ZNF462 gene Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). Indicus|evm.model.CM009492.1.815 Q58CN8 SESN2_BOVIN 100.000 0.995763 1.00212 SESN2 - Sestrin-2 - Bos taurus (Bovine) - SESN2 gene Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress. Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed. Indicus|evm.model.CM009492.1.816 P01096 ATIF1_BOVIN 100.000 0.981818 1.00917 ATP5IF1 - ATPase inhibitor, mitochondrial precursor - Bos taurus (Bovine) - ATP5IF1 gene Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indicus|evm.model.CM009492.1.817 Q642C0 DNJC8_RAT 99.605 0.992126 1.00395 Dnajc8 - DnaJ homolog subfamily C member 8 - Rattus norvegicus (Rat) - Dnajc8 gene Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells. Indicus|evm.model.CM009492.1.818 P61246 RS3A_FELCA 95.876 0.979592 0.376923 RPS3A - 40S ribosomal protein S3a - Felis catus (Cat) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009492.1.819 P61247 RS3A_HUMAN 98.701 0.987097 0.587121 RPS3A - 40S ribosomal protein S3a - Homo sapiens (Human) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009492.1.820 Q9TTY5 PTAFR_BOVIN 99.708 0.966006 1.03216 PTAFR - Platelet-activating factor receptor - Bos taurus (Bovine) - PTAFR gene Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. May be involved in the morphological and physical modifications of the oviduct and uterus during the estrus cycle and early pregnancy (By similarity). Indicus|evm.model.CM009492.1.821 A5A6H4 ROA1_PANTR 88.235 0.923077 0.284375 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Indicus|evm.model.CM009492.1.822 Q32P51 RA1L2_HUMAN 88.679 0.590909 0.275 HNRNPA1L2 - Heterogeneous nuclear ribonucleoprotein A1-like 2 - Homo sapiens (Human) - HNRNPA1L2 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. Indicus|evm.model.CM009492.1.823 Q99504 EYA3_HUMAN 96.510 0.877301 1.13787 EYA3 - Eyes absent homolog 3 - Homo sapiens (Human) - EYA3 gene Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. Indicus|evm.model.CM009492.1.824 Q49LS0 XKR8_PANTR 77.975 0.956098 1.03797 XKR8 - XK-related protein 8 - Pan troglodytes (Chimpanzee) - XKR8 gene Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis (By similarity). Indicus|evm.model.CM009492.1.825 Q92485 ASM3B_HUMAN 84.383 0.975369 0.892308 SMPDL3B - Acid sphingomyelinase-like phosphodiesterase 3b precursor - Homo sapiens (Human) - SMPDL3B gene Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity). Indicus|evm.model.CM009492.1.826 P15927 RFA2_HUMAN 93.333 0.739011 1.34815 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Indicus|evm.model.CM009492.1.827 Q5TEJ8 THMS2_HUMAN 71.273 0.99689 1 THEMIS2 - Protein THEMIS2 - Homo sapiens (Human) - THEMIS2 gene May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity). Indicus|evm.model.CM009492.1.828 Q12972 PP1R8_HUMAN 99.415 0.616637 1.5755 PPP1R8 - Nuclear inhibitor of protein phosphatase 1 - Homo sapiens (Human) - PPP1R8 gene Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Indicus|evm.model.CM009492.1.829 Q86Y82 STX12_HUMAN 96.887 0.930909 0.996377 STX12 - Syntaxin-12 - Homo sapiens (Human) - STX12 gene SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Indicus|evm.model.CM009492.1.830 Q5EA89 FA76A_BOVIN 99.674 0.993506 1.00326 FAM76A - Protein FAM76A - Bos taurus (Bovine) - FAM76A gene nucleoplasm Indicus|evm.model.CM009492.1.831 Q6IED8 IFI6_BOVIN 100.000 0.985185 1.00746 IFI6 - Interferon alpha-inducible protein 6 - Bos taurus (Bovine) - IFI6 gene Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (By similarity). However, it has also been shown to have a pro-apoptotic activity (By similarity). May have an antiviral activity (By similarity). Indicus|evm.model.CM009492.1.833 P09769 FGR_HUMAN 89.981 0.996212 0.99811 FGR - Tyrosine-protein kinase Fgr - Homo sapiens (Human) - FGR gene Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Indicus|evm.model.CM009492.1.834 Q5TGY3 AHDC1_HUMAN 96.509 0.998748 0.996881 AHDC1 - AT-hook DNA-binding motif-containing protein 1 - Homo sapiens (Human) - AHDC1 gene Indicus|evm.model.CM009492.1.835 A2VDK6 WASF2_BOVIN 100.000 0.995951 1.00203 WASF2 - Wiskott-Aldrich syndrome protein family member 2 - Bos taurus (Bovine) - WASF2 gene Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Indicus|evm.model.CM009492.1.836 P46089 GPR3_HUMAN 95.455 0.993958 1.00303 GPR3 - G-protein coupled receptor 3 - Homo sapiens (Human) - GPR3 gene Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity). Indicus|evm.model.CM009492.1.837 Q6UWJ8 C16L2_HUMAN 89.595 0.988506 1 CD164L2 - CD164 sialomucin-like 2 protein precursor - Homo sapiens (Human) - CD164L2 gene cytoplasmic vesicle Indicus|evm.model.CM009492.1.838 O95382 M3K6_HUMAN 87.972 0.995385 1.00932 MAP3K6 - Mitogen-activated protein kinase kinase kinase 6 - Homo sapiens (Human) - MAP3K6 gene Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. Indicus|evm.model.CM009492.1.839 Q8IYJ3 SYTL1_HUMAN 79.693 0.996593 1.04448 SYTL1 - Synaptotagmin-like protein 1 - Homo sapiens (Human) - SYTL1 gene May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). Indicus|evm.model.CM009492.1.840 Q9H0R3 TM222_HUMAN 69.020 0.992032 1.20673 TMEM222 - Transmembrane protein 222 - Homo sapiens (Human) - TMEM222 gene Indicus|evm.model.CM009492.1.841 Q8N5D0 WDTC1_HUMAN 77.528 0.93617 0.138848 WDTC1 - WD and tetratricopeptide repeats protein 1 - Homo sapiens (Human) - WDTC1 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Indicus|evm.model.CM009492.1.842 Q80ZK9 WDTC1_MOUSE 97.122 0.638889 0.319055 Wdtc1 - WD and tetratricopeptide repeats protein 1 - Mus musculus (Mouse) - Wdtc1 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Indicus|evm.model.CM009492.1.843 Q8N5D0 WDTC1_HUMAN 99.513 0.995146 0.608567 WDTC1 - WD and tetratricopeptide repeats protein 1 - Homo sapiens (Human) - WDTC1 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Indicus|evm.model.CM009492.1.845 Q28036 SL9A1_BOVIN 99.389 0.997558 1.00245 SLC9A1 - Sodium/hydrogen exchanger 1 - Bos taurus (Bovine) - SLC9A1 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Indicus|evm.model.CM009492.1.846 Q29RH2 TET5B_BOVIN 100.000 0.99536 1.00233 TENT5B - Terminal nucleotidyltransferase 5B - Bos taurus (Bovine) - TENT5B gene Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase. Indicus|evm.model.CM009492.1.847 Q8NAX2 KDF1_HUMAN 92.462 0.994987 1.00251 KDF1 - Keratinocyte differentiation factor 1 - Homo sapiens (Human) - KDF1 gene Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). Indicus|evm.model.CM009492.1.848 Q17QG2 NUDC_BOVIN 99.699 0.993994 1.00301 NUDC - Nuclear migration protein nudC - Bos taurus (Bovine) - NUDC gene Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity). Necessary for cytokinesis and cell proliferation (By similarity). Indicus|evm.model.CM009492.1.849 Q15466 NR0B2_HUMAN 79.537 0.988506 1.01556 NR0B2 - Nuclear receptor subfamily 0 group B member 2 - Homo sapiens (Human) - NR0B2 gene Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity). Indicus|evm.model.CM009492.1.850 Q96I76 GPTC3_HUMAN 83.810 0.968105 1.01524 GPATCH3 - G patch domain-containing protein 3 - Homo sapiens (Human) - GPATCH3 gene Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768). Indicus|evm.model.CM009492.1.851 A6H7F2 GPN2_BOVIN 100.000 0.993569 1.00323 GPN2 - GPN-loop GTPase 2 - Bos taurus (Bovine) - GPN2 gene Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. Indicus|evm.model.CM009492.1.852 O77642 1433S_SHEEP 100.000 0.991968 1.00403 SFN - 14-3-3 protein sigma - Ovis aries (Sheep) - SFN gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity). Indicus|evm.model.CM009492.1.853 Q9NUE0 ZDH18_HUMAN 89.965 0.944262 0.786082 ZDHHC18 - Palmitoyltransferase ZDHHC18 - Homo sapiens (Human) - ZDHHC18 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:23034182, PubMed:27481942). Palmitoylates HRAS and LCK (By similarity). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). Indicus|evm.model.CM009492.1.854 Q9NUD9 PIGV_HUMAN 84.381 0.995951 1.00203 PIGV - GPI mannosyltransferase 2 - Homo sapiens (Human) - PIGV gene Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Indicus|evm.model.CM009492.1.855 O14497 ARI1A_HUMAN 95.529 0.998986 0.86302 ARID1A - AT-rich interactive domain-containing protein 1A - Homo sapiens (Human) - ARID1A gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Indicus|evm.model.CM009492.1.856 Q15418 KS6A1_HUMAN 99.048 0.997283 1.00136 RPS6KA1 - Ribosomal protein S6 kinase alpha-1 - Homo sapiens (Human) - RPS6KA1 gene Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Indicus|evm.model.CM009492.1.857 P42558 RAN_CHICK 70.270 0.813333 0.347222 RAN - GTP-binding nuclear protein Ran - Gallus gallus (Chicken) - RAN gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. Indicus|evm.model.CM009492.1.858 P80272 HMGN2_PIG 100.000 0.792453 1.17778 HMGN2 - Non-histone chromosomal protein HMG-17 - Sus scrofa (Pig) - HMGN2 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). Indicus|evm.model.CM009492.1.859 Q86SQ9 DHDDS_HUMAN 94.910 0.99403 1.00601 DHDDS - Dehydrodolichyl diphosphate synthase complex subunit DHDDS - Homo sapiens (Human) - DHDDS gene With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490, PubMed:32817466). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). Indicus|evm.model.CM009492.1.860 Q8K3Y3 LN28A_MOUSE 95.694 0.990291 0.985646 Lin28a - Protein lin-28 homolog A - Mus musculus (Mouse) - Lin28a gene RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:17473174, PubMed:18604195, PubMed:18566191, PubMed:18292307, PubMed:19703396, PubMed:23102813, PubMed:24209617). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (PubMed:26045559). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (PubMed:17473174). Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferaseS. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:19703396, PubMed:28671666). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins (PubMed:23102813). Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (PubMed:24209617). Indicus|evm.model.CM009492.1.861 Q60636 PRDM1_MOUSE 70.946 0.280392 0.595794 Prdm1 - PR domain zinc finger protein 1 - Mus musculus (Mouse) - Prdm1 gene Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity). Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484). Indicus|evm.model.CM009492.1.862 Q8N1P7 CRBG2_HUMAN 76.684 0.628844 1.13546 CRYBG2 - Beta/gamma crystallin domain-containing protein 2 - Homo sapiens (Human) - CRYBG2 gene Indicus|evm.model.CM009492.1.863 Q28896 CD52_CANLF 70.149 0.969697 0.985075 CD52 - CAMPATH-1 antigen precursor - Canis lupus familiaris (Dog) - CD52 gene May play a role in carrying and orienting carbohydrate, as well as having a more specific role. Indicus|evm.model.CM009492.1.864 Q5T124 UBX11_HUMAN 79.773 0.931034 0.892308 UBXN11 - UBX domain-containing protein 11 - Homo sapiens (Human) - UBXN11 gene May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity). Indicus|evm.model.CM009492.1.865 Q9H299 SH3L3_HUMAN 100.000 0.978723 1.01075 SH3BGRL3 - SH3 domain-binding glutamic acid-rich-like protein 3 - Homo sapiens (Human) - SH3BGRL3 gene Could act as a modulator of glutaredoxin biological activity. Indicus|evm.model.CM009492.1.866 Q6P2H3 CEP85_HUMAN 88.036 0.570045 1.76115 CEP85 - Centrosomal protein of 85 kDa - Homo sapiens (Human) - CEP85 gene Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). Indicus|evm.model.CM009492.1.867 Q7RTX7 CTSR4_HUMAN 77.676 0.804455 0.855932 CATSPER4 - Cation channel sperm-associated protein 4 - Homo sapiens (Human) - CATSPER4 gene Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Indicus|evm.model.CM009492.1.868 Q969H4 CNKR1_HUMAN 84.211 0.965812 0.325 CNKSR1 - Connector enhancer of kinase suppressor of ras 1 - Homo sapiens (Human) - CNKSR1 gene May function as an adapter protein or regulator of Ras signaling pathways. Indicus|evm.model.CM009492.1.869 Q8BVN3 CTSR4_MOUSE 63.158 0.836364 0.248869 Catsper4 - Cation channel sperm-associated protein 4 - Mus musculus (Mouse) - Catsper4 gene Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Indicus|evm.model.CM009492.1.870 Q969H4 CNKR1_HUMAN 75.304 0.896104 0.748611 CNKSR1 - Connector enhancer of kinase suppressor of ras 1 - Homo sapiens (Human) - CNKSR1 gene May function as an adapter protein or regulator of Ras signaling pathways. Indicus|evm.model.CM009492.1.871 O00488 ZN593_HUMAN 93.284 0.985185 1.00746 ZNF593 - Zinc finger protein 593 - Homo sapiens (Human) - ZNF593 gene Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins. Indicus|evm.model.CM009492.1.872 A0A0U1RR37 CA232_HUMAN 83.333 0.98895 0.973118 C1orf232 - Uncharacterized protein C1orf232 - Homo sapiens (Human) - C1orf232 gene Indicus|evm.model.CM009492.1.873 A6H7I7 F110D_BOVIN 100.000 0.99262 1.0037 FAM110D - Protein FAM110D - Bos taurus (Bovine) - FAM110D gene Indicus|evm.model.CM009492.1.874 Q8QZR7 PDK1L_MOUSE 99.413 0.994152 1.00293 Pdik1l - Serine/threonine-protein kinase PDIK1L - Mus musculus (Mouse) - Pdik1l gene nucleoplasm, nucleus, protein kinase activity, protein serine/threonine kinase activity, meiotic cell cycle Indicus|evm.model.CM009492.1.875 Q969Q1 TRI63_HUMAN 93.272 0.91831 1.00567 TRIM63 - E3 ubiquitin-protein ligase TRIM63 - Homo sapiens (Human) - TRIM63 gene E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. Indicus|evm.model.CM009492.1.876 Q62941 ZNT2_RAT 78.212 0.946809 1.04735 Slc30a2 - Zinc transporter 2 - Rattus norvegicus (Rat) - Slc30a2 gene Involved in accumulation of zinc in endosomal/lysosomal vesicles. Indicus|evm.model.CM009492.1.877 Q92935 EXTL1_HUMAN 78.171 0.997041 1 EXTL1 - Exostosin-like 1 - Homo sapiens (Human) - EXTL1 gene Probable glycosyltransferase. Indicus|evm.model.CM009492.1.878 P79106 PAFA2_BOVIN 99.235 0.92435 1.07908 PAFAH2 - Platelet-activating factor acetylhydrolase 2, cytoplasmic - Bos taurus (Bovine) - PAFAH2 gene Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:7673213, PubMed:8955149, PubMed:9405438). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (PubMed:7673213). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity). Indicus|evm.model.CM009492.1.879 Q6DUB7 STMN1_PIG 100.000 0.986667 1.00671 STMN1 - Stathmin - Sus scrofa (Pig) - STMN1 gene Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). Indicus|evm.model.CM009492.1.880 Q865K8 PAQR7_PIG 96.857 0.994302 1.00286 PAQR7 - Membrane progestin receptor alpha - Sus scrofa (Pig) - PAQR7 gene Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone. Indicus|evm.model.CM009492.1.881 A4IFU8 AUNIP_BOVIN 100.000 0.994413 1.0028 AUNIP - Aurora kinase A and ninein-interacting protein - Bos taurus (Bovine) - AUNIP gene DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle. Indicus|evm.model.CM009492.1.882 Q3ZBW7 MFR1L_BOVIN 100.000 0.993103 1.00346 MTFR1L - Mitochondrial fission regulator 1-like - Bos taurus (Bovine) - MTFR1L gene mitochondrion, aerobic respiration, mitochondrial fission Indicus|evm.model.CM009492.1.883 Q9NZV5 SELN_HUMAN 93.750 0.954887 0.225424 SELENON - Selenoprotein N precursor - Homo sapiens (Human) - SELENON gene Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863). Indicus|evm.model.CM009492.1.884 D3Z2R5 SELN_MOUSE 91.304 0.955729 0.689408 Selenon - Selenoprotein N precursor - Mus musculus (Mouse) - Selenon gene Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (By similarity). Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290). Indicus|evm.model.CM009492.1.885 Q9NR34 MA1C1_HUMAN 93.317 0.943567 0.703175 MAN1C1 - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC - Homo sapiens (Human) - MAN1C1 gene Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc. Indicus|evm.model.CM009492.1.886 Q9NR34 MA1C1_HUMAN 80.543 0.745763 0.468254 MAN1C1 - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC - Homo sapiens (Human) - MAN1C1 gene Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc. Indicus|evm.model.CM009492.1.887 Q5SW96 ARH_HUMAN 91.613 0.993569 1.00974 LDLRAP1 - Low density lipoprotein receptor adapter protein 1 - Homo sapiens (Human) - LDLRAP1 gene Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). Indicus|evm.model.CM009492.1.888 Q2TLZ3 MACOI_BOVIN 100.000 0.996992 1.00151 MACO1 - Macoilin - Bos taurus (Bovine) - MACO1 gene Plays a role in the regulation of neuronal activity. Indicus|evm.model.CM009492.1.889 Q28426 RHLC_GORGO 58.421 0.979328 0.928058 RH-like protein IC - Gorilla gorilla gorilla (Western lowland gorilla) Indicus|evm.model.CM009492.1.890 O95807 TM50A_HUMAN 96.178 0.987342 1.00637 TMEM50A - Transmembrane protein 50A - Homo sapiens (Human) - TMEM50A gene endoplasmic reticulum, late endosome to vacuole transport via multivesicular body sorting pathway Indicus|evm.model.CM009492.1.891 Q4QRB2 SYF2_RAT 93.220 0.491632 1.97521 Syf2 - Pre-mRNA-splicing factor SYF2 - Rattus norvegicus (Rat) - Syf2 gene Involved in pre-mRNA splicing as component of the spliceosome. Indicus|evm.model.CM009492.1.893 Q13761 RUNX3_HUMAN 91.286 0.904943 0.633735 RUNX3 - Runt-related transcription factor 3 - Homo sapiens (Human) - RUNX3 gene Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Indicus|evm.model.CM009492.1.894 Q9XSA7 CLIC4_BOVIN 100.000 0.992126 1.00395 CLIC4 - Chloride intracellular channel protein 4 - Bos taurus (Bovine) - CLIC4 gene Can insert into membranes and form chloride ion channels. Indicus|evm.model.CM009492.1.895 Q5R5Q2 SRRM1_PONAB 97.710 0.997817 0.998909 SRRM1 - Serine/arginine repetitive matrix protein 1 - Pongo abelii (Sumatran orangutan) - SRRM1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. Indicus|evm.model.CM009492.1.896 Q5T1S8 NCMAP_HUMAN 87.255 0.639241 1.54902 NCMAP - Noncompact myelin-associated protein - Homo sapiens (Human) - NCMAP gene Plays a role in myelin formation. Indicus|evm.model.CM009492.1.897 Q2KIA1 RCAN3_BOVIN 99.585 0.991736 1.00415 RCAN3 - Calcipressin-3 - Bos taurus (Bovine) - RCAN3 gene Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity). Indicus|evm.model.CM009492.1.898 Q5RD30 NPAL3_PONAB 94.089 0.995086 1.00246 NIPAL3 - NIPA-like protein 3 - Pongo abelii (Sumatran orangutan) - NIPAL3 gene Indicus|evm.model.CM009492.1.899 A6QQ60 STPG1_BOVIN 99.403 0.994048 1.00299 STPG1 - O(6)-methylguanine-induced apoptosis 2 - Bos taurus (Bovine) - STPG1 gene May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. Indicus|evm.model.CM009492.1.900 Q5FWH3 GRHL3_MOUSE 90.216 0.996683 1 Grhl3 - Grainyhead-like protein 3 homolog - Mus musculus (Mouse) - Grhl3 gene Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. Essential for epidermal differentiation and barrier formation at the end of embryogenesis with TGM3 as critical direct target (PubMed:21081122, PubMed:20654612, PubMed:25347468). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair (PubMed:21081122). Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury (PubMed:25347468). Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (PubMed:14608380, PubMed:20654612). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL1, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122). Indicus|evm.model.CM009492.1.902 Q8IU57 INLR1_HUMAN 65.730 0.99619 1.00962 IFNLR1 - Interferon lambda receptor 1 precursor - Homo sapiens (Human) - IFNLR1 gene The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Indicus|evm.model.CM009492.1.903 Q3SYS8 I22R1_BOVIN 97.935 0.996564 1.00172 IL22RA1 - Interleukin-22 receptor subunit alpha-1 precursor - Bos taurus (Bovine) - IL22RA1 gene Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation (By similarity). Indicus|evm.model.CM009492.1.904 Q5VTT5 MYOM3_HUMAN 84.551 0.99786 0.975644 MYOM3 - Myomesin-3 - Homo sapiens (Human) - MYOM3 gene May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. Indicus|evm.model.CM009492.1.905 Q5R8I2 RTRAF_PONAB 68.675 0.727273 0.45082 RTRAF - RNA transcription, translation and transport factor protein - Pongo abelii (Sumatran orangutan) - RTRAF gene RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport. Indicus|evm.model.CM009492.1.906 Q9R0U0 SRS10_MOUSE 92.614 0.892857 0.748092 Srsf10 - Serine/arginine-rich splicing factor 10 - Mus musculus (Mouse) - Srsf10 gene Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity). May be involved in regulation of alternative splicing in neurons (PubMed:10583508). Indicus|evm.model.CM009492.1.907 Q0VCW6 PNRC2_BOVIN 99.281 0.985714 1.00719 PNRC2 - Proline-rich nuclear receptor coactivator 2 - Bos taurus (Bovine) - PNRC2 gene Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. Indicus|evm.model.CM009492.1.908 P34972 CNR2_HUMAN 82.730 0.98895 1.00556 CNR2 - Cannabinoid receptor 2 - Homo sapiens (Human) - CNR2 gene Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Indicus|evm.model.CM009492.1.909 Q2KIM0 FUCO_BOVIN 99.573 0.995736 1.00214 FUCA1 - Tissue alpha-L-fucosidase precursor - Bos taurus (Bovine) - FUCA1 gene Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Indicus|evm.model.CM009492.1.910 Q29448 HMGCL_BOVIN 100.000 0.993865 1.00308 HMGCL - Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor - Bos taurus (Bovine) - HMGCL gene Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. Indicus|evm.model.CM009492.1.911 Q3T105 GALE_BOVIN 99.713 0.699597 1.42529 GALE - UDP-glucose 4-epimerase - Bos taurus (Bovine) - GALE gene Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. Indicus|evm.model.CM009492.1.912 O95372 LYPA2_HUMAN 98.496 0.94964 0.601732 LYPLA2 - Acyl-protein thioesterase 2 - Homo sapiens (Human) - LYPLA2 gene Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951). Indicus|evm.model.CM009492.1.913 Q9GZP4 PITH1_HUMAN 98.578 0.990566 1.00474 PITHD1 - PITH domain-containing protein 1 - Homo sapiens (Human) - PITHD1 gene Promotes megakaryocyte differentiation by up-regulating RUNX1 expression (PubMed:25134913). Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene (PubMed:25134913). Indicus|evm.model.CM009492.1.914 Q14241 ELOA1_HUMAN 83.230 0.997509 1.00627 ELOA - Elongin-A - Homo sapiens (Human) - ELOA gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Indicus|evm.model.CM009492.1.915 P62914 RL11_RAT 100.000 0.988827 1.00562 Rpl11 - 60S ribosomal protein L11 - Rattus norvegicus (Rat) - Rpl11 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Promotes nucleolar location of PML. Indicus|evm.model.CM009492.1.916 Q5E981 ID3_BOVIN 100.000 0.983333 1.0084 ID3 - DNA-binding protein inhibitor ID-3 - Bos taurus (Bovine) - ID3 gene Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Indicus|evm.model.CM009492.1.917 Q14209 E2F2_HUMAN 84.636 0.989305 0.855835 E2F2 - Transcription factor E2F2 - Homo sapiens (Human) - E2F2 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Indicus|evm.model.CM009492.1.918 Q8TDY4 ASAP3_HUMAN 88.386 0.958751 0.993355 ASAP3 - Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 - Homo sapiens (Human) - ASAP3 gene Promotes cell proliferation. Indicus|evm.model.CM009492.1.919 Q5R5Y7 ZN436_PONAB 96.596 0.548538 1.81915 ZNF436 - Zinc finger protein 436 - Pongo abelii (Sumatran orangutan) - ZNF436 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009492.1.920 O43390 HNRPR_HUMAN 99.842 0.996845 1.00158 HNRNPR - Heterogeneous nuclear ribonucleoprotein R - Homo sapiens (Human) - HNRNPR gene Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. Indicus|evm.model.CM009492.1.921 P79400 5HT1D_PIG 95.189 0.767196 1.29897 HTR1D - 5-hydroxytryptamine receptor 1D - Sus scrofa (Pig) - HTR1D gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction (By similarity). Indicus|evm.model.CM009492.1.923 Q9NY97 B3GN2_HUMAN 82.836 0.923611 0.36272 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Homo sapiens (Human) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. Indicus|evm.model.CM009492.1.924 Q86V48 LUZP1_HUMAN 84.494 0.998134 0.996283 LUZP1 - Leucine zipper protein 1 - Homo sapiens (Human) - LUZP1 gene extracellular exosome, membrane, neural fold bending Indicus|evm.model.CM009492.1.925 O60341 KDM1A_HUMAN 95.652 0.997714 1.027 KDM1A - Lysine-specific histone demethylase 1A - Homo sapiens (Human) - KDM1A gene Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16140033, PubMed:16079794, PubMed:16079795, PubMed:16223729). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16140033, PubMed:16079794, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Indicus|evm.model.CM009492.1.926 H3BTG2 TEX46_HUMAN 60.526 0.92638 1.34711 TEX46 - Testis-expressed protein 46 precursor - Homo sapiens (Human) - TEX46 gene Indicus|evm.model.CM009492.1.927 A8MY62 BLML_HUMAN 89.189 0.125 1.168 LACTBL1 - Putative beta-lactamase-like 1 - Homo sapiens (Human) - LACTBL1 gene Indicus|evm.model.CM009492.1.928 P29323 EPHB2_HUMAN 99.720 0.853047 0.793365 EPHB2 - Ephrin type-B receptor 2 precursor - Homo sapiens (Human) - EPHB2 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). Indicus|evm.model.CM009492.1.929 P29323 EPHB2_HUMAN 99.123 0.729904 0.294787 EPHB2 - Ephrin type-B receptor 2 precursor - Homo sapiens (Human) - EPHB2 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). Indicus|evm.model.CM009492.1.930 Q2KIV9 C1QB_BOVIN 94.979 0.706231 1.36437 C1QB - Complement C1q subcomponent subunit B precursor - Bos taurus (Bovine) - C1QB gene C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes (By similarity). Indicus|evm.model.CM009492.1.931 P02747 C1QC_HUMAN 78.733 0.901639 0.995918 C1QC - Complement C1q subcomponent subunit C precursor - Homo sapiens (Human) - C1QC gene C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Indicus|evm.model.CM009492.1.932 Q5E9E3 C1QA_BOVIN 99.590 0.991837 1.0041 C1QA - Complement C1q subcomponent subunit A precursor - Bos taurus (Bovine) - C1QA gene C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Indicus|evm.model.CM009492.1.933 P29322 EPHA8_HUMAN 96.735 0.967391 1.00697 EPHA8 - Ephrin type-A receptor 8 precursor - Homo sapiens (Human) - EPHA8 gene Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). Indicus|evm.model.CM009492.1.934 Q9NUA8 ZBT40_HUMAN 83.387 0.998387 1.00081 ZBTB40 - Zinc finger and BTB domain-containing protein 40 - Homo sapiens (Human) - ZBTB40 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009492.1.936 P56705 WNT4_HUMAN 99.692 0.964286 0.957265 WNT4 - Protein Wnt-4 precursor - Homo sapiens (Human) - WNT4 gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:15317892, PubMed:16959810, PubMed:18179883, PubMed:18182450). Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity). Indicus|evm.model.CM009492.1.937 Q4R4R6 CDC42_MACFA 100.000 0.986486 0.774869 CDC42 - Cell division control protein 42 homolog precursor - Macaca fascicularis (Crab-eating macaque) - CDC42 gene Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity). Indicus|evm.model.CM009492.1.938 Q32PG5 SCND1_BOVIN 72.222 0.493056 0.808989 SCAND1 - SCAN domain-containing protein 1 - Bos taurus (Bovine) - SCAND1 gene May regulate transcriptional activity. Indicus|evm.model.CM009492.1.939 P05805 CAC3_BOVIN 99.605 0.929889 1.07115 Proproteinase E precursor - Bos taurus (Bovine) Indicus|evm.model.CM009492.1.941 P98160 PGBM_HUMAN 89.115 0.994548 1.00251 HSPG2 - Basement membrane-specific heparan sulfate proteoglycan core protein precursor - Homo sapiens (Human) - HSPG2 gene Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Indicus|evm.model.CM009492.1.942 Q5SZI1 LRAD2_HUMAN 75.720 0.695402 1.27941 LDLRAD2 - Low-density lipoprotein receptor class A domain-containing protein 2 precursor - Homo sapiens (Human) - LDLRAD2 gene Indicus|evm.model.CM009492.1.943 Q86UV5 UBP48_HUMAN 97.780 0.998071 1.00193 USP48 - Ubiquitin carboxyl-terminal hydrolase 48 - Homo sapiens (Human) - USP48 gene Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Indicus|evm.model.CM009492.1.944 P47736 RPGP1_HUMAN 93.614 0.912467 1.13725 RAP1GAP - Rap1 GTPase-activating protein 1 - Homo sapiens (Human) - RAP1GAP gene GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. Indicus|evm.model.CM009492.1.945 P09487 PPBT_BOVIN 99.809 0.99619 1.00191 ALPL - Alkaline phosphatase, tissue-nonspecific isozyme precursor - Bos taurus (Bovine) - ALPL gene This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi). Indicus|evm.model.CM009492.1.946 P42891 ECE1_BOVIN 99.867 0.997347 1 ECE1 - Endothelin-converting enzyme 1 - Bos taurus (Bovine) - ECE1 gene Converts big endothelin-1 to endothelin-1. Indicus|evm.model.CM009492.1.947 O43432 IF4G3_HUMAN 92.550 0.869493 0.758991 EIF4G3 - Eukaryotic translation initiation factor 4 gamma 3 - Homo sapiens (Human) - EIF4G3 gene Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1. Indicus|evm.model.CM009492.1.948 Q08DU9 HP1B3_BOVIN 100.000 0.996403 1.0018 HP1BP3 - Heterochromatin protein 1-binding protein 3 - Bos taurus (Bovine) - HP1BP3 gene Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis. Indicus|evm.model.CM009492.1.949 Q6ZV89 SH2D5_HUMAN 90.421 0.995338 1.01418 SH2D5 - SH2 domain-containing protein 5 - Homo sapiens (Human) - SH2D5 gene May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. Indicus|evm.model.CM009492.1.950 Q9P2E2 KIF17_HUMAN 77.038 0.997988 0.965986 KIF17 - Kinesin-like protein KIF17 - Homo sapiens (Human) - KIF17 gene Dendrite-specific motor protein which, in association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. Indicus|evm.model.CM009492.1.951 A6QPY0 OST48_BOVIN 92.027 0.781853 1.17995 DDOST - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor - Bos taurus (Bovine) - DDOST gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity). Indicus|evm.model.CM009492.1.952 P56389 CDD_MOUSE 90.411 0.223765 4.43836 Cda - Cytidine deaminase - Mus musculus (Mouse) - Cda gene This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Indicus|evm.model.CM009492.1.953 Q6ZT52 FA43B_HUMAN 94.972 0.747899 0.723404 FAM43B - Protein FAM43B - Homo sapiens (Human) - FAM43B gene Indicus|evm.model.CM009492.1.954 Q969V5 MUL1_HUMAN 83.003 0.994302 0.997159 MUL1 - Mitochondrial ubiquitin ligase activator of NFKB 1 - Homo sapiens (Human) - MUL1 gene Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion (PubMed:21597459). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697). Indicus|evm.model.CM009492.1.955 A7MBG3 CK2N1_BOVIN 100.000 0.974684 1.01282 CAMK2N1 - Calcium/calmodulin-dependent protein kinase II inhibitor 1 - Bos taurus (Bovine) - CAMK2N1 gene Potent and specific inhibitor of CaM-kinase II (CAMK2). Indicus|evm.model.CM009492.1.956 A9Z1V5 VW5B1_MOUSE 71.722 0.669596 0.936626 Vwa5b1 - von Willebrand factor A domain-containing protein 5B1 precursor - Mus musculus (Mouse) - Vwa5b1 gene Indicus|evm.model.CM009492.1.957 Q96LJ8 UBX10_HUMAN 72.143 0.989362 1.00714 UBXN10 - UBX domain-containing protein 10 - Homo sapiens (Human) - UBXN10 gene VCP/p97-binding protein required for ciliogenesis (PubMed:26389662). Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia (PubMed:26389662). UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 (PubMed:26389662). Indicus|evm.model.CM009492.1.958 P39878 PA2GC_RAT 67.763 0.986842 1.01333 Pla2g2c - Group IIC secretory phospholipase A2 precursor - Rattus norvegicus (Rat) - Pla2g2c gene PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Indicus|evm.model.CM009492.1.959 Q9BZM2 PA2GF_HUMAN 77.632 0.967949 0.928571 PLA2G2F - Group IIF secretory phospholipase A2 precursor - Homo sapiens (Human) - PLA2G2F gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:11112443). May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity). Indicus|evm.model.CM009492.1.960 Q9UNK4 PA2GD_HUMAN 60.690 0.739583 1.32414 PLA2G2D - Group IID secretory phospholipase A2 precursor - Homo sapiens (Human) - PLA2G2D gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10681567). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (By similarity). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (By similarity). May act in an autocrine and paracrine manner (By similarity). Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (By similarity). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity). Indicus|evm.model.CM009492.1.961 Q9UNK4 PA2GD_HUMAN 59.310 0.739583 1.32414 PLA2G2D - Group IID secretory phospholipase A2 precursor - Homo sapiens (Human) - PLA2G2D gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10681567). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (By similarity). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (By similarity). May act in an autocrine and paracrine manner (By similarity). Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (By similarity). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity). Indicus|evm.model.CM009492.1.962 P39877 PA2G5_HUMAN 73.913 0.985612 1.00725 PLA2G5 - Phospholipase A2 group V precursor - Homo sapiens (Human) - PLA2G5 gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:8300559). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (PubMed:8300559, PubMed:14998370, PubMed:23533611). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes (PubMed:23533611). Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines (PubMed:25725101). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (PubMed:12124392, PubMed:12796497). In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way (PubMed:12796497). In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (PubMed:12124392). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (By similarity). May regulate antigen processing in antigen-presenting cells (By similarity). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370). Indicus|evm.model.CM009492.1.963 P14555 PA2GA_HUMAN 47.500 0.362791 1.49306 PLA2G2A - Phospholipase A2, membrane associated precursor - Homo sapiens (Human) - PLA2G2A gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (PubMed:10455175, PubMed:10681567, PubMed:2925633). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175, PubMed:10681567). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541, PubMed:10358193). Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (PubMed:25082876). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370). Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536). Indicus|evm.model.CM009492.1.964 Q56JZ2 PA2GA_BOVIN 94.444 0.986207 1.00694 PLA2G2A - Phospholipase A2, membrane associated precursor - Bos taurus (Bovine) - PLA2G2A gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (By similarity). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (By similarity). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner (By similarity). Indicus|evm.model.CM009492.1.965 Q56JZ2 PA2GA_BOVIN 68.750 0.986207 1.00694 PLA2G2A - Phospholipase A2, membrane associated precursor - Bos taurus (Bovine) - PLA2G2A gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (By similarity). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (By similarity). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner (By similarity). Indicus|evm.model.CM009492.1.967 Q9QUL3 PA2GE_MOUSE 86.620 0.986014 1.00704 Pla2g2e - Group IIE secretory phospholipase A2 precursor - Mus musculus (Mouse) - Pla2g2e gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:11922621, PubMed:10531313). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), releasing various unsaturated fatty acids including oleoate, linoleoate, arachidonate, docosahexaenoate and lysophosphatidylethanolamines in preference to lysophosphatidylcholines (By similarity). In response to high-fat diet, hydrolyzes minor lipoprotein phospholipids including phosphatidylserines, phosphatidylinositols and phosphatidylglycerols, altering lipoprotein composition and fat storage in adipose tissue and liver (PubMed:24910243). May act in an autocrine and paracrine manner (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (By similarity). Acts as a hair follicle phospholipase A2. Selectively releases lysophosphatidylethanolamines (LPE) and various unsaturated fatty acids in skin to regulate hair follicle homeostasis (PubMed:27226633). May regulate the inflammatory response by releasing arachidonate, a precursor of prostaglandins and leukotrienes. Upon allergen exposure, may participate in allergic inflammatory response by enhancing leukotriene C4 synthesis and degranulation in mast cells (PubMed:11922621). Indicus|evm.model.CM009492.1.969 Q5T2D3 OTUD3_HUMAN 89.950 0.994975 1 OTUD3 - OTU domain-containing protein 3 - Homo sapiens (Human) - OTUD3 gene Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Indicus|evm.model.CM009492.1.970 Q3T0Y9 RN186_BOVIN 97.788 0.991189 1.00442 RNF186 - E3 ubiquitin-protein ligase RNF186 - Bos taurus (Bovine) - RNF186 gene E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. In that process, stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Indicus|evm.model.CM009492.1.972 Q5TGY1 TMCO4_HUMAN 86.457 0.99684 0.998423 TMCO4 - Transmembrane and coiled-coil domain-containing protein 4 - Homo sapiens (Human) - TMCO4 gene Indicus|evm.model.CM009492.1.973 P31388 5HT6R_RAT 91.014 0.780045 1.01147 Htr6 - 5-hydroxytryptamine receptor 6 - Rattus norvegicus (Rat) - Htr6 gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (PubMed:7680751). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (By similarity). Indicus|evm.model.CM009492.1.974 P41271 NBL1_HUMAN 93.370 0.988764 0.983425 NBL1 - Neuroblastoma suppressor of tumorigenicity 1 precursor - Homo sapiens (Human) - NBL1 gene Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Indicus|evm.model.CM009492.1.975 Q5TGZ0 MIC10_HUMAN 96.154 0.974684 1.01282 MICOS10 - MICOS complex subunit MIC10 - Homo sapiens (Human) - MICOS10 gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Indicus|evm.model.CM009492.1.976 P47756 CAPZB_HUMAN 98.188 0.895765 1.1083 CAPZB - F-actin-capping protein subunit beta - Homo sapiens (Human) - CAPZB gene F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Indicus|evm.model.CM009492.1.977 Q6ZP29 LAAT1_HUMAN 84.880 0.993151 1.00344 SLC66A1 - Lysosomal amino acid transporter 1 homolog - Homo sapiens (Human) - SLC66A1 gene Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. Indicus|evm.model.CM009492.1.978 O43488 ARK72_HUMAN 90.347 0.973585 0.738162 AKR7A2 - Aflatoxin B1 aldehyde reductase member 2 - Homo sapiens (Human) - AKR7A2 gene Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Indicus|evm.model.CM009492.1.979 O95154 ARK73_HUMAN 76.780 0.949153 0.891239 AKR7A3 - Aflatoxin B1 aldehyde reductase member 3 - Homo sapiens (Human) - AKR7A3 gene Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Indicus|evm.model.CM009492.1.980 O43488 ARK72_HUMAN 57.669 0.616915 0.559889 AKR7A2 - Aflatoxin B1 aldehyde reductase member 2 - Homo sapiens (Human) - AKR7A2 gene Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Indicus|evm.model.CM009492.1.981 A4FV84 MRT4_BOVIN 100.000 0.991667 1.00418 MRTO4 - mRNA turnover protein 4 homolog - Bos taurus (Bovine) - MRTO4 gene Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. Indicus|evm.model.CM009492.1.982 Q8N766 EMC1_HUMAN 93.656 0.997986 1 EMC1 - ER membrane protein complex subunit 1 precursor - Homo sapiens (Human) - EMC1 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Indicus|evm.model.CM009492.1.983 Q5T4S7 UBR4_HUMAN 96.836 0.999614 0.999807 UBR4 - E3 ubiquitin-protein ligase UBR4 - Homo sapiens (Human) - UBR4 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. Indicus|evm.model.CM009492.1.984 P0C6R4 IFFO2_RAT 97.561 0.731458 1.36237 Iffo2 - Intermediate filament family orphan 2 - Rattus norvegicus (Rat) - Iffo2 gene Indicus|evm.model.CM009492.1.985 A7YWE4 AL4A1_BOVIN 99.467 0.996454 1.00178 ALDH4A1 - Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ALDH4A1 gene Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). Indicus|evm.model.CM009492.1.986 Q49HI0 TS1R2_CANLF 75.000 0.231373 0.305024 TAS1R2 - Taste receptor type 1 member 2 precursor - Canis lupus familiaris (Dog) - TAS1R2 gene Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity). Indicus|evm.model.CM009492.1.987 Q49HI0 TS1R2_CANLF 78.077 0.834586 1.11364 TAS1R2 - Taste receptor type 1 member 2 precursor - Canis lupus familiaris (Dog) - TAS1R2 gene Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity). Indicus|evm.model.CM009492.1.989 P23759 PAX7_HUMAN 98.020 0.996024 0.99604 PAX7 - Paired box protein Pax-7 - Homo sapiens (Human) - PAX7 gene Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. Indicus|evm.model.CM009492.1.991 Q5R866 KLD7A_PONAB 68.448 0.983689 1.03776 KLHDC7A - Kelch domain-containing protein 7A - Pongo abelii (Sumatran orangutan) - KLHDC7A gene Indicus|evm.model.CM009492.1.992 Q96ID5 IGS21_HUMAN 82.174 0.912525 1.07709 IGSF21 - Immunoglobulin superfamily member 21 precursor - Homo sapiens (Human) - IGSF21 gene Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2. Indicus|evm.model.CM009492.1.993 M0RAS4 IGS21_RAT 100.000 0.521127 0.151709 Igsf21 - Immunoglobulin superfamily member 21 precursor - Rattus norvegicus (Rat) - Igsf21 gene Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2. Indicus|evm.model.CM009492.1.995 Q9H568 ACTL8_HUMAN 72.131 0.994536 1 ACTL8 - Actin-like protein 8 - Homo sapiens (Human) - ACTL8 gene dynactin complex, epithelial cell differentiation Indicus|evm.model.CM009492.1.996 Q29RM4 ARGAL_BOVIN 99.837 0.923135 1.07276 ARHGEF10L - Rho guanine nucleotide exchange factor 10-like protein - Bos taurus (Bovine) - ARHGEF10L gene Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. Indicus|evm.model.CM009492.1.997 Q9P258 RCC2_HUMAN 98.818 0.948315 0.85249 RCC2 - Protein RCC2 - Homo sapiens (Human) - RCC2 gene Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:23388455, PubMed:12919680, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). Indicus|evm.model.CM009492.1.998 Q6TGC4 PADI6_HUMAN 70.520 0.997097 0.992795 PADI6 - Protein-arginine deiminase type-6 - Homo sapiens (Human) - PADI6 gene Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678). Indicus|evm.model.CM009492.1.999 Q9UM07 PADI4_HUMAN 73.913 0.996997 1.00452 PADI4 - Protein-arginine deiminase type-4 - Homo sapiens (Human) - PADI4 gene Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (PubMed:18209087). Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription (PubMed:15345777). Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (PubMed:15731352). Indicus|evm.model.CM009492.1.1000 O02849 PADI3_SHEEP 92.018 0.996992 1.00151 PADI3 - Protein-arginine deiminase type-3 - Ovis aries (Sheep) - PADI3 gene Catalyzes the deimination of arginine residues of proteins. Indicus|evm.model.CM009492.1.1001 Q9ULC6 PADI1_HUMAN 77.883 0.969325 0.983409 PADI1 - Protein-arginine deiminase type-1 - Homo sapiens (Human) - PADI1 gene Catalyzes the deimination of arginine residues of proteins. Indicus|evm.model.CM009492.1.1005 Q9Y2J8 PADI2_HUMAN 91.880 0.996997 1.0015 PADI2 - Protein-arginine deiminase type-2 - Homo sapiens (Human) - PADI2 gene Catalyzes the deimination of arginine residues of proteins. Indicus|evm.model.CM009492.1.1006 Q3T189 SDHB_BOVIN 100.000 0.975524 1.02143 SDHB - Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor - Bos taurus (Bovine) - SDHB gene Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Indicus|evm.model.CM009492.1.1007 Q9NQ11 AT132_HUMAN 83.814 0.998294 0.99322 ATP13A2 - Polyamine-transporting ATPase 13A2 - Homo sapiens (Human) - ATP13A2 gene ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine (PubMed:31996848). Also stimulates cellular uptake of polyamines and protects against polyamine toxicity (PubMed:31996848). Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Contributes to cellular zinc homeostasis (PubMed:24603074). Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress (PubMed:26134396). Required for proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957). Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels (PubMed:27278822). Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Promotes secretion of exosomes as well as secretion of SCNA via exosomes (PubMed:25392495, PubMed:24603074). Plays a role in lipid homeostasis (PubMed:31132336). Indicus|evm.model.CM009492.1.1008 P27424 MFAP2_BOVIN 99.454 0.98913 1.00546 MFAP2 - Microfibrillar-associated protein 2 precursor - Bos taurus (Bovine) - MFAP2 gene Component of the elastin-associated microfibrils. Indicus|evm.model.CM009492.1.1009 Q5TZA2 CROCC_HUMAN 83.252 0.679827 1.02975 CROCC - Rootletin - Homo sapiens (Human) - CROCC gene Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). Indicus|evm.model.CM009492.1.1010 Q5E9Q4 NECP2_BOVIN 99.624 0.992509 1.00376 NECAP2 - Adaptin ear-binding coat-associated protein 2 - Bos taurus (Bovine) - NECAP2 gene Involved in endocytosis. Indicus|evm.model.CM009492.1.1011 Q68A65 SPT21_RAT 69.608 0.354369 1.20292 Spata21 - Spermatogenesis-associated protein 21 - Rattus norvegicus (Rat) - Spata21 gene Involved in the differentiation of haploid spermatids. Indicus|evm.model.CM009492.1.1012 Q2KI04 SZRD1_BOVIN 100.000 0.986928 1.00658 SZRD1 - SUZ domain-containing protein 1 - Bos taurus (Bovine) - SZRD1 gene Indicus|evm.model.CM009492.1.1013 Q6P3S6 FBX42_HUMAN 94.979 0.923871 1.08089 FBXO42 - F-box only protein 42 - Homo sapiens (Human) - FBXO42 gene Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. Indicus|evm.model.CM009492.1.1014 Q9BU20 CPLN2_HUMAN 91.803 0.558891 1.67829 CPLANE2 - Ciliogenesis and planar polarity effector 2 - Homo sapiens (Human) - CPLANE2 gene Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity). Indicus|evm.model.CM009492.1.1015 Q8IW93 ARHGJ_HUMAN 89.480 0.997525 1.00748 ARHGEF19 - Rho guanine nucleotide exchange factor 19 - Homo sapiens (Human) - ARHGEF19 gene Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Indicus|evm.model.CM009492.1.1016 P29317 EPHA2_HUMAN 93.705 0.990779 1 EPHA2 - Ephrin type-A receptor 2 precursor - Homo sapiens (Human) - EPHA2 gene Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Indicus|evm.model.CM009492.1.1018 Q96AQ9 F131C_HUMAN 70.076 0.991935 0.885714 FAM131C - Protein FAM131C - Homo sapiens (Human) - FAM131C gene Indicus|evm.model.CM009492.1.1019 P51803 CLCKA_RABIT 86.351 0.991441 1.02038 CLCNKA - Chloride channel protein ClC-Ka - Oryctolagus cuniculus (Rabbit) - CLCNKA gene Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Indicus|evm.model.CM009492.1.1021 Q9UBY9 HSPB7_HUMAN 88.506 0.988235 1 HSPB7 - Heat shock protein beta-7 - Homo sapiens (Human) - HSPB7 gene aggresome, cytoplasm, nucleoplasm, nucleus, protein C-terminus binding, regulation of heart contraction, response to unfolded protein Indicus|evm.model.CM009492.1.1022 Q8NEQ6 SRARP_HUMAN 50.000 0.965174 1.18935 SRARP - Steroid receptor-associated and regulated protein - Homo sapiens (Human) - SRARP gene May regulate the transcriptional function of androgen and estrogen receptors. Indicus|evm.model.CM009492.1.1026 Q6NXG1 ESRP1_HUMAN 91.406 0.983773 0.723935 ESRP1 - Epithelial splicing regulatory protein 1 - Homo sapiens (Human) - ESRP1 gene mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). Indicus|evm.model.CM009492.1.1027 Q6NXG1 ESRP1_HUMAN 97.692 0.928058 0.204112 ESRP1 - Epithelial splicing regulatory protein 1 - Homo sapiens (Human) - ESRP1 gene mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). Indicus|evm.model.CM009492.1.1029 Q4GWZ2 RSSA_PIG 51.493 0.966667 0.40678 RPSA - 40S ribosomal protein SA - Sus scrofa (Pig) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. Indicus|evm.model.CM009493.1.2 Q8NH69 OR5W2_HUMAN 74.157 0.988764 0.287097 OR5W2 - Olfactory receptor 5W2 - Homo sapiens (Human) - OR5W2 gene Odorant receptor. Indicus|evm.model.CM009493.1.3 Q9DGD1 MGT4C_CHICK 45.293 0.8394 1.00647 MGAT4C - Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase - Gallus gallus (Chicken) - MGAT4C gene Glycosyltransferase that catalyzes the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (also named 'GnT-VI' activity). May also participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans by catalyzing the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Indicus|evm.model.CM009493.1.4 Q5XNS0 TBX19_CANLF 92.381 0.943694 0.997753 TBX19 - T-box transcription factor TBX19 - Canis lupus familiaris (Dog) - TBX19 gene Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters (By similarity). Indicus|evm.model.CM009493.1.5 O95562 SFT2B_HUMAN 90.000 0.987578 1.00625 SFT2D2 - Vesicle transport protein SFT2B - Homo sapiens (Human) - SFT2D2 gene May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Indicus|evm.model.CM009493.1.6 Q8BH58 TIPRL_MOUSE 97.426 0.992674 1.00738 Tiprl - TIP41-like protein - Mus musculus (Mouse) - Tiprl gene May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity). Indicus|evm.model.CM009493.1.7 Q2YDN1 GP161_BOVIN 99.811 0.996219 1.00189 GPR161 - G protein-coupled receptor 161 - Bos taurus (Bovine) - GPR161 gene Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). Indicus|evm.model.CM009493.1.9 Q5R9B8 DCAF6_PONAB 96.522 0.490909 1.08721 DCAF6 - DDB1- and CUL4-associated factor 6 - Pongo abelii (Sumatran orangutan) - DCAF6 gene Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). Indicus|evm.model.CM009493.1.10 O95563 MPC2_HUMAN 96.063 0.984375 1.00787 MPC2 - Mitochondrial pyruvate carrier 2 - Homo sapiens (Human) - MPC2 gene Mediates the uptake of pyruvate into mitochondria. Indicus|evm.model.CM009493.1.11 Q866F4 ADCYA_RABIT 86.121 0.998762 1.00311 ADCY10 - Adenylate cyclase type 10 - Oryctolagus cuniculus (Rabbit) - ADCY10 gene Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity). Indicus|evm.model.CM009493.1.12 Q32PI9 MPZL1_BOVIN 99.257 0.992593 1.00372 MPZL1 - Myelin protein zero-like protein 1 precursor - Bos taurus (Bovine) - MPZL1 gene Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility (By similarity). Indicus|evm.model.CM009493.1.13 Q3ZBT0 CPZIP_BOVIN 99.475 0.994764 1.00262 RCSD1 - CapZ-interacting protein - Bos taurus (Bovine) - RCSD1 gene Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. Indicus|evm.model.CM009493.1.14 O75629 CREG1_HUMAN 81.900 0.990991 1.00909 CREG1 - Protein CREG1 precursor - Homo sapiens (Human) - CREG1 gene May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. Indicus|evm.model.CM009493.1.15 P29329 CD3Z_SHEEP 95.181 0.988024 1.00602 CD247 - T-cell surface glycoprotein CD3 zeta chain precursor - Ovis aries (Sheep) - CD247 gene Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN). Indicus|evm.model.CM009493.1.16 Q29076 PO2F1_PIG 97.181 0.96749 1.03221 POU2F1 - POU domain, class 2, transcription factor 1 - Sus scrofa (Pig) - POU2F1 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. Indicus|evm.model.CM009493.1.17 Q5VZP5 STYL2_HUMAN 84.682 0.998274 1.00086 STYXL2 - Serine/threonine/tyrosine-interacting-like protein 2 - Homo sapiens (Human) - STYXL2 gene May be required for myofiber maturation. Indicus|evm.model.CM009493.1.18 Q99795 GPA33_HUMAN 72.039 0.952532 0.990596 GPA33 - Cell surface A33 antigen precursor - Homo sapiens (Human) - GPA33 gene May play a role in cell-cell recognition and signaling. Indicus|evm.model.CM009493.1.19 Q32KV2 MAEL_BOVIN 94.048 0.995 0.952381 MAEL - Protein maelstrom homolog - Bos taurus (Bovine) - MAEL gene Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). Indicus|evm.model.CM009493.1.20 Q71H61 ILDR2_HUMAN 88.189 0.996759 0.965571 ILDR2 - Immunoglobulin-like domain-containing receptor 2 precursor - Homo sapiens (Human) - ILDR2 gene May be involved in lipid homeostasis and ER stress pathways. Indicus|evm.model.CM009493.1.21 A6QR06 TADA1_BOVIN 100.000 0.994048 1.00299 TADA1 - Transcriptional adapter 1 - Bos taurus (Bovine) - TADA1 gene Probably involved in transcriptional regulation. Indicus|evm.model.CM009493.1.22 Q9P215 POGK_HUMAN 95.567 0.983819 1.01478 POGK - Pogo transposable element with KRAB domain - Homo sapiens (Human) - POGK gene nucleoplasm, nucleus, DNA binding Indicus|evm.model.CM009493.1.23 Q04799 FMO5_RABIT 54.685 0.934783 1.03565 FMO5 - Flavin-containing monooxygenase 5 - Oryctolagus cuniculus (Rabbit) - FMO5 gene Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (By similarity). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (By similarity). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). Indicus|evm.model.CM009493.1.24 Q32LC9 ZN330_BOVIN 88.438 0.993289 0.93125 ZNF330 - Zinc finger protein 330 - Bos taurus (Bovine) - ZNF330 gene nucleus Indicus|evm.model.CM009493.1.25 Q8BQN5 FA78B_MOUSE 94.737 0.925926 0.310345 Fam78b - Protein FAM78B - Mus musculus (Mouse) - Fam78b gene Indicus|evm.model.CM009493.1.27 Q8BQN5 FA78B_MOUSE 100.000 0.900524 0.731801 Fam78b - Protein FAM78B - Mus musculus (Mouse) - Fam78b gene Indicus|evm.model.CM009493.1.28 Q9QYG8 UCK2_RAT 100.000 0.0771084 1.59004 Uck2 - Uridine-cytidine kinase 2 - Rattus norvegicus (Rat) - Uck2 gene Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (By similarity). Indicus|evm.model.CM009493.1.29 Q5I0H4 TMCO1_RAT 100.000 0.989418 1.00532 Tmco1 - Calcium load-activated calcium channel - Rattus norvegicus (Rat) - Tmco1 gene Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Together with SEC61 and TMEM147, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity. Indicus|evm.model.CM009493.1.30 Q2KJH9 AL9A1_BOVIN 100.000 0.946257 1.05466 ALDH9A1 - 4-trimethylaminobutyraldehyde dehydrogenase - Bos taurus (Bovine) - ALDH9A1 gene Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Indicus|evm.model.CM009493.1.31 Q3T100 MGST3_BOVIN 100.000 0.867816 1.14474 MGST3 - Microsomal glutathione S-transferase 3 - Bos taurus (Bovine) - MGST3 gene Also functions as a glutathione peroxidase. Indicus|evm.model.CM009493.1.32 Q8N7C0 LRC52_HUMAN 76.238 0.993421 0.971246 LRRC52 - Leucine-rich repeat-containing protein 52 precursor - Homo sapiens (Human) - LRRC52 gene Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties. Indicus|evm.model.CM009493.1.33 Q0VC20 RXRG_BOVIN 89.633 0.995204 0.900648 RXRG - Retinoic acid receptor RXR-gamma - Bos taurus (Bovine) - RXRG gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). Indicus|evm.model.CM009493.1.35 Q9JKU8 LMX1A_MOUSE 97.753 0.807339 0.28534 Lmx1a - LIM homeobox transcription factor 1-alpha - Mus musculus (Mouse) - Lmx1a gene Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae. Indicus|evm.model.CM009493.1.36 Q9JKU8 LMX1A_MOUSE 100.000 0.506579 0.397906 Lmx1a - LIM homeobox transcription factor 1-alpha - Mus musculus (Mouse) - Lmx1a gene Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae. Indicus|evm.model.CM009493.1.37 Q8TE12 LMX1A_HUMAN 90.909 0.948 0.65445 LMX1A - LIM homeobox transcription factor 1-alpha - Homo sapiens (Human) - LMX1A gene Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity). Indicus|evm.model.CM009493.1.38 P41778 PBX1_MOUSE 100.000 0.99536 1.00233 Pbx1 - Pre-B-cell leukemia transcription factor 1 - Mus musculus (Mouse) - Pbx1 gene Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (By similarity). Binds the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (By similarity). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (By similarity). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (PubMed:19799567). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (PubMed:32190943). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (PubMed:7913464). Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4 (By similarity). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (PubMed:22560297). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). Indicus|evm.model.CM009493.1.39 P20821 GCSH_BOVIN 100.000 0.981818 0.635838 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Indicus|evm.model.CM009493.1.40 Q9BZD4 NUF2_HUMAN 91.540 0.987124 1.00431 NUF2 - Kinetochore protein Nuf2 - Homo sapiens (Human) - NUF2 gene Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Indicus|evm.model.CM009493.1.41 Q29RM9 RGS4_BOVIN 100.000 0.990291 1.00488 RGS4 - Regulator of G-protein signaling 4 - Bos taurus (Bovine) - RGS4 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity). Indicus|evm.model.CM009493.1.42 Q3T0T8 RGS5_BOVIN 100.000 0.948276 0.961326 RGS5 - Regulator of G-protein signaling 5 - Bos taurus (Bovine) - RGS5 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). Indicus|evm.model.CM009493.1.43 Q1RMX6 CC190_BOVIN 98.990 0.983389 1.01689 CCDC190 - Coiled-coil domain-containing protein 190 - Bos taurus (Bovine) - CCDC190 gene Indicus|evm.model.CM009493.1.44 P56937 DHB7_HUMAN 85.586 0.991045 0.982405 HSD17B7 - 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 - Homo sapiens (Human) - HSD17B7 gene Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:19772289, PubMed:11165030). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193). Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585, PubMed:11165030). Indicus|evm.model.CM009493.1.45 Q16832 DDR2_HUMAN 97.427 0.997664 1.00117 DDR2 - Discoidin domain-containing receptor 2 precursor - Homo sapiens (Human) - DDR2 gene Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. Indicus|evm.model.CM009493.1.46 Q16222 UAP1_HUMAN 96.169 0.996176 1.00192 UAP1 - UDP-N-acetylhexosamine pyrophosphorylase - Homo sapiens (Human) - UAP1 gene Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P. Indicus|evm.model.CM009493.1.47 Q28918 STAR_BOVIN 99.298 0.993007 1.00351 STAR - Steroidogenic acute regulatory protein, mitochondrial precursor - Bos taurus (Bovine) - STAR gene Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). Indicus|evm.model.CM009493.1.48 Q5RCY1 UHMK1_PONAB 99.761 0.995238 1.00239 UHMK1 - Serine/threonine-protein kinase Kist - Pongo abelii (Sumatran orangutan) - UHMK1 gene Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity). Indicus|evm.model.CM009493.1.50 A6QLD2 OLM2B_BOVIN 99.606 0.997375 1.00395 OLFML2B - Olfactomedin-like protein 2B precursor - Bos taurus (Bovine) - OLFML2B gene Indicus|evm.model.CM009493.1.51 P18850 ATF6A_HUMAN 92.526 0.905995 1.09552 ATF6 - Cyclic AMP-dependent transcription factor ATF-6 alpha - Homo sapiens (Human) - ATF6 gene Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464). Indicus|evm.model.CM009493.1.52 Q9UNI6 DUS12_HUMAN 83.383 0.971098 1.01765 DUSP12 - Dual specificity protein phosphatase 12 - Homo sapiens (Human) - DUSP12 gene Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). Indicus|evm.model.CM009493.1.53 Q6BAA4 FCRLB_HUMAN 86.150 0.995215 0.981221 FCRLB - Fc receptor-like B precursor - Homo sapiens (Human) - FCRLB gene cytoplasm, integral component of plasma membrane, transmembrane signaling receptor activity, cell surface receptor signaling pathway, negative regulation of immune response Indicus|evm.model.CM009493.1.54 Q63273 GRIK5_RAT 55.491 0.580913 0.24617 Grik5 - Glutamate receptor ionotropic, kainate 5 precursor - Rattus norvegicus (Rat) - Grik5 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA. Indicus|evm.model.CM009493.1.55 Q7L513 FCRLA_HUMAN 77.519 0.966165 0.740947 FCRLA - Fc receptor-like A precursor - Homo sapiens (Human) - FCRLA gene May be implicated in B-cell differentiation and lymphomagenesis. Indicus|evm.model.CM009493.1.56 Q28110 FCGR2_BOVIN 93.080 0.993103 0.97973 FCGR2 - Low affinity immunoglobulin gamma Fc region receptor II precursor - Bos taurus (Bovine) - FCGR2 gene Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. Indicus|evm.model.CM009493.1.57 P79107 FCGR3_BOVIN 98.000 0.992032 1.004 FCGR3 - Low affinity immunoglobulin gamma Fc region receptor III precursor - Bos taurus (Bovine) - FCGR3 gene Is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Also mediates antibody-dependent cellular toxicity (By similarity). Indicus|evm.model.CM009493.1.58 Q04967 HSP76_PIG 95.179 0.996894 1.00156 HSPA6 - Heat shock 70 kDa protein 6 - Sus scrofa (Pig) - HSPA6 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Indicus|evm.model.CM009493.1.59 Q28110 FCGR2_BOVIN 94.180 0.917073 0.692568 FCGR2 - Low affinity immunoglobulin gamma Fc region receptor II precursor - Bos taurus (Bovine) - FCGR2 gene Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. Indicus|evm.model.CM009493.1.62 Q3SZT6 FLTOP_BOVIN 100.000 0.989848 1.0051 CFAP126 - Protein Flattop - Bos taurus (Bovine) - CFAP126 gene Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear. Indicus|evm.model.CM009493.1.63 P35720 C560_BOVIN 100.000 0.988235 1.00592 SDHC - Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor - Bos taurus (Bovine) - SDHC gene Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Indicus|evm.model.CM009493.1.64 P10522 MYP0_BOVIN 100.000 0.991968 1.00403 MPZ - Myelin protein P0 precursor - Bos taurus (Bovine) - MPZ gene Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. Indicus|evm.model.CM009493.1.65 A8R4Q8 PC4L1_BOVIN 100.000 0.916667 1.04348 PCP4L1 - Purkinje cell protein 4-like protein 1 - Bos taurus (Bovine) - PCP4L1 gene Indicus|evm.model.CM009493.1.66 P62045 NR1I3_PUSSI 84.195 0.922872 1.08046 NR1I3 - Nuclear receptor subfamily 1 group I member 3 - Pusa sibirica (Baikal seal) - NR1I3 gene Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity). Indicus|evm.model.CM009493.1.67 A6QR22 TM40L_BOVIN 100.000 0.993528 1.00325 TOMM40L - Mitochondrial import receptor subunit TOM40B - Bos taurus (Bovine) - TOMM40L gene Potential channel-forming protein implicated in import of protein precursors into mitochondria. Indicus|evm.model.CM009493.1.68 P81644 APOA2_BOVIN 100.000 0.980198 1.01 APOA2 - Apolipoprotein A-II precursor - Bos taurus (Bovine) - APOA2 gene May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Has antimicrobial activity. Indicus|evm.model.CM009493.1.69 P17694 NDUS2_BOVIN 100.000 0.77403 1.28078 NDUFS2 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor - Bos taurus (Bovine) - NDUFS2 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for the catalytic activity and assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (By similarity). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity). Indicus|evm.model.CM009493.1.70 Q5EA87 B4GT3_BOVIN 99.747 0.313741 3.17929 B4GALT3 - Beta-1,4-galactosyltransferase 3 - Bos taurus (Bovine) - B4GALT3 gene Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Indicus|evm.model.CM009493.1.71 P56602 PPOX_BOVIN 99.790 0.979424 1.01887 PPOX - Protoporphyrinogen oxidase - Bos taurus (Bovine) - PPOX gene Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Indicus|evm.model.CM009493.1.72 Q2KJ72 UBP21_BOVIN 99.823 0.705882 1.41416 USP21 - Ubiquitin carboxyl-terminal hydrolase 21 - Bos taurus (Bovine) - USP21 gene Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization. Indicus|evm.model.CM009493.1.74 O75618 DEDD_HUMAN 98.742 0.99373 1.00314 DEDD - Death effector domain-containing protein - Homo sapiens (Human) - DEDD gene A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). Indicus|evm.model.CM009493.1.75 Q32LH4 NIT1_BOVIN 99.656 0.993151 0.890244 NIT1 - Deaminated glutathione amidase precursor - Bos taurus (Bovine) - NIT1 gene Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells. It is also a negative regulator of primary T-cells. Indicus|evm.model.CM009493.1.76 A1A4P5 PFD2_BOVIN 100.000 0.987097 1.00649 PFDN2 - Prefoldin subunit 2 - Bos taurus (Bovine) - PFDN2 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Indicus|evm.model.CM009493.1.77 Q8NEP7 KLDC9_HUMAN 87.679 0.991404 1 KLHDC9 - Kelch domain-containing protein 9 - Homo sapiens (Human) - KLHDC9 gene cyclin binding Indicus|evm.model.CM009493.1.78 Q5E9Z9 NECT4_BOVIN 99.608 0.996086 1.00196 NECTIN4 - Nectin-4 precursor - Bos taurus (Bovine) - NECTIN4 gene Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Indicus|evm.model.CM009493.1.79 Q7Z6I6 RHG30_HUMAN 80.325 0.998177 0.996367 ARHGAP30 - Rho GTPase-activating protein 30 - Homo sapiens (Human) - ARHGAP30 gene GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. Indicus|evm.model.CM009493.1.80 Q6XBT4 USF1_BOVIN 100.000 0.993569 1.00323 USF1 - Upstream stimulatory factor 1 - Bos taurus (Bovine) - USF1 gene Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Indicus|evm.model.CM009493.1.81 Q8NFU3 TSTD1_HUMAN 89.474 0.817518 1.1913 TSTD1 - Thiosulfate:glutathione sulfurtransferase - Homo sapiens (Human) - TSTD1 gene Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). Indicus|evm.model.CM009493.1.82 Q9XT56 JAM1_BOVIN 100.000 0.692494 1.38591 F11R - Junctional adhesion molecule A precursor - Bos taurus (Bovine) - F11R gene Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. Indicus|evm.model.CM009493.1.83 Q8WWU7 ITLN2_HUMAN 84.013 0.650924 1.49846 ITLN2 - Intelectin-2 precursor - Homo sapiens (Human) - ITLN2 gene May play a role in the defense system against pathogens. Indicus|evm.model.CM009493.1.84 Q8WWA0 ITLN1_HUMAN 85.560 0.899023 0.980831 ITLN1 - Intelectin-1 precursor - Homo sapiens (Human) - ITLN1 gene Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499). Indicus|evm.model.CM009493.1.85 Q8WWA0 ITLN1_HUMAN 80.392 0.409836 0.389776 ITLN1 - Intelectin-1 precursor - Homo sapiens (Human) - ITLN1 gene Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499). Indicus|evm.model.CM009493.1.86 Q8WWA0 ITLN1_HUMAN 84.483 0.376906 1.46645 ITLN1 - Intelectin-1 precursor - Homo sapiens (Human) - ITLN1 gene Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499). Indicus|evm.model.CM009493.1.87 Q8VE62 PAIP1_MOUSE 91.275 0.763496 0.9725 Paip1 - Polyadenylate-binding protein-interacting protein 1 - Mus musculus (Mouse) - Paip1 gene Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Indicus|evm.model.CM009493.1.88 Q8VE62 PAIP1_MOUSE 83.673 0.209607 0.5725 Paip1 - Polyadenylate-binding protein-interacting protein 1 - Mus musculus (Mouse) - Paip1 gene Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Indicus|evm.model.CM009493.1.89 Q9BZW8 CD244_HUMAN 55.759 0.99458 0.997297 CD244 - Natural killer cell receptor 2B4 precursor - Homo sapiens (Human) - CD244 gene Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). Indicus|evm.model.CM009493.1.90 Q9HBG7 LY9_HUMAN 61.219 0.650273 0.838168 LY9 - T-lymphocyte surface antigen Ly-9 precursor - Homo sapiens (Human) - LY9 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). Indicus|evm.model.CM009493.1.92 Q2TBS4 PIFO_BOVIN 100.000 0.837719 1.1875 PIFO - Protein pitchfork - Bos taurus (Bovine) - PIFO gene During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner (By similarity). Indicus|evm.model.CM009493.1.93 Q28042 OVGP1_BOVIN 90.099 0.776235 1.2067 OVGP1 - Oviduct-specific glycoprotein precursor - Bos taurus (Bovine) - OVGP1 gene Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. Indicus|evm.model.CM009493.1.94 Q9NQ25 SLAF7_HUMAN 59.292 0.994065 1.00597 SLAMF7 - SLAM family member 7 precursor - Homo sapiens (Human) - SLAMF7 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528). Indicus|evm.model.CM009493.1.95 P09326 CD48_HUMAN 56.846 0.983333 0.987654 CD48 - CD48 antigen precursor - Homo sapiens (Human) - CD48 gene Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. Indicus|evm.model.CM009493.1.96 Q95MM9 SLAF1_CANLF 68.513 0.9941 0.991228 SLAMF1 - Signaling lymphocytic activation molecule precursor - Canis lupus familiaris (Dog) - SLAMF1 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1. Mediates IL-2-independent proliferation of activated T cells during immune responses and induces IFN-gamma production. Downstreaming signaling involves INPP5D/SHIP1, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production. Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells. Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells. Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells. May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells. May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion. In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type. In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A. In conjunction with SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response. Indicus|evm.model.CM009493.1.97 Q9UIB8 SLAF5_HUMAN 69.855 0.960227 1.02029 CD84 - SLAM family member 5 precursor - Homo sapiens (Human) - CD84 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592). Indicus|evm.model.CM009493.1.98 Q96DU3 SLAF6_HUMAN 52.522 0.94051 1.06325 SLAMF6 - SLAM family member 6 precursor - Homo sapiens (Human) - SLAMF6 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity). Indicus|evm.model.CM009493.1.99 Q9ULK5 VANG2_HUMAN 99.808 0.996169 1.00192 VANGL2 - Vang-like protein 2 - Homo sapiens (Human) - VANGL2 gene Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). Indicus|evm.model.CM009493.1.100 Q02575 HEN1_HUMAN 96.992 0.985075 1.00752 NHLH1 - Helix-loop-helix protein 1 - Homo sapiens (Human) - NHLH1 gene May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. Indicus|evm.model.CM009493.1.101 Q92542 NICA_HUMAN 88.717 0.997183 1.00141 NCSTN - Nicastrin precursor - Homo sapiens (Human) - NCSTN gene Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Indicus|evm.model.CM009493.1.102 Q27954 COPA_BOVIN 99.918 0.998367 1.00082 COPA - Coatomer subunit alpha - Bos taurus (Bovine) - COPA gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Indicus|evm.model.CM009493.1.103 Q3SZD1 PEX19_BOVIN 100.000 0.993333 1.00334 PEX19 - Peroxisomal biogenesis factor 19 precursor - Bos taurus (Bovine) - PEX19 gene Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity). Indicus|evm.model.CM009493.1.104 Q5TAQ9 DCAF8_HUMAN 97.822 0.996622 0.991625 DCAF8 - DDB1- and CUL4-associated factor 8 - Homo sapiens (Human) - DCAF8 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Indicus|evm.model.CM009493.1.105 Q5U318 PEA15_RAT 100.000 0.984733 1.00769 Pea15 - Astrocytic phosphoprotein PEA-15 - Rattus norvegicus (Rat) - Pea15 gene Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). Indicus|evm.model.CM009493.1.106 P19633 CASQ1_RAT 94.588 0.977273 0.975369 Casq1 - Calsequestrin-1 precursor - Rattus norvegicus (Rat) - Casq1 gene Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:8042990). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). Indicus|evm.model.CM009493.1.107 Q13733 AT1A4_HUMAN 86.505 0.99806 1.00194 ATP1A4 - Sodium/potassium-transporting ATPase subunit alpha-4 - Homo sapiens (Human) - ATP1A4 gene This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. Indicus|evm.model.CM009493.1.108 A2VDL6 AT1A2_BOVIN 100.000 0.998041 1.00098 ATP1A2 - Sodium/potassium-transporting ATPase subunit alpha-2 precursor - Bos taurus (Bovine) - ATP1A2 gene This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (By similarity). Indicus|evm.model.CM009493.1.109 Q969P0 IGSF8_HUMAN 91.892 0.967267 0.996737 IGSF8 - Immunoglobulin superfamily member 8 precursor - Homo sapiens (Human) - IGSF8 gene May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. Indicus|evm.model.CM009493.1.110 Q63511 KCNJ9_RAT 96.049 0.995074 1.03308 Kcnj9 - G protein-activated inward rectifier potassium channel 3 - Rattus norvegicus (Rat) - Kcnj9 gene This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). Indicus|evm.model.CM009493.1.111 P78508 KCJ10_HUMAN 98.681 0.994737 1.00264 KCNJ10 - ATP-sensitive inward rectifier potassium channel 10 - Homo sapiens (Human) - KCNJ10 gene May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. Indicus|evm.model.CM009493.1.112 Q5EA10 PIGM_BOVIN 99.764 0.995283 1.00236 PIGM - GPI mannosyltransferase 1 - Bos taurus (Bovine) - PIGM gene Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity). Indicus|evm.model.CM009493.1.113 Q96A28 SLAF9_HUMAN 69.349 0.896552 1.00346 SLAMF9 - SLAM family member 9 precursor - Homo sapiens (Human) - SLAMF9 gene May play a role in the immune response. Indicus|evm.model.CM009493.1.114 Q9P2J2 TUTLA_HUMAN 89.992 0.998305 1.00085 IGSF9 - Protein turtle homolog A precursor - Homo sapiens (Human) - IGSF9 gene Functions in dendrite outgrowth and synapse maturation. Indicus|evm.model.CM009493.1.115 Q5E9F5 TAGL2_BOVIN 100.000 0.99 1.00503 TAGLN2 - Transgelin-2 - Bos taurus (Bovine) - TAGLN2 gene Indicus|evm.model.CM009493.1.116 Q9UL16 CFA45_HUMAN 90.563 0.996364 0.998185 CFAP45 - Cilia- and flagella-associated protein 45 - Homo sapiens (Human) - CFAP45 gene nucleoplasm, nucleus Indicus|evm.model.CM009493.1.117 P0DPA3 SNH28_HUMAN 82.979 0.220379 1.79574 SNHG28 - Putative uncharacterized protein SNHG28 - Homo sapiens (Human) - SNHG28 gene RNA binding Indicus|evm.model.CM009493.1.118 Q9P0V8 SLAF8_HUMAN 80.524 0.453767 2.04912 SLAMF8 - SLAM family member 8 precursor - Homo sapiens (Human) - SLAMF8 gene May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. Indicus|evm.model.CM009493.1.119 Q6NT99 DUS23_MOUSE 96.000 0.986755 1.00667 Dusp23 - Dual specificity protein phosphatase 23 - Mus musculus (Mouse) - Dusp23 gene Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). Indicus|evm.model.CM009493.1.120 P02741 CRP_HUMAN 70.089 0.991111 1.00446 CRP - C-reactive protein precursor - Homo sapiens (Human) - CRP gene Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Indicus|evm.model.CM009493.1.121 Q3T004 SAMP_BOVIN 99.099 0.72459 1.36161 APCS - Serum amyloid P-component precursor - Bos taurus (Bovine) - APCS gene extracellular space, complement component C1q complex binding, low-density lipoprotein particle binding, complement activation, classical pathway, innate immune response, negative regulation by host of viral process Indicus|evm.model.CM009493.1.122 Q99728 BARD1_HUMAN 82.353 0.967213 0.157014 BARD1 - BRCA1-associated RING domain protein 1 - Homo sapiens (Human) - BARD1 gene E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. Indicus|evm.model.CM009493.1.123 P0C629 O10J4_HUMAN 90.857 0.988636 0.565916 OR10J4 - Olfactory receptor 10J4 - Homo sapiens (Human) - OR10J4 gene Odorant receptor. Indicus|evm.model.CM009493.1.124 P30954 O10J1_HUMAN 83.516 0.708661 0.396875 OR10J1 - Olfactory receptor 10J1 - Homo sapiens (Human) - OR10J1 gene Odorant receptor. Indicus|evm.model.CM009493.1.125 Q5JRS4 O10J3_HUMAN 91.216 0.825843 0.541033 OR10J3 - Olfactory receptor 10J3 - Homo sapiens (Human) - OR10J3 gene Odorant receptor. Indicus|evm.model.CM009493.1.126 P12319 FCERA_HUMAN 60.784 0.97318 1.01556 FCER1A - High affinity immunoglobulin epsilon receptor subunit alpha precursor - Homo sapiens (Human) - FCER1A gene Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. Indicus|evm.model.CM009493.1.127 Q3T166 MPTX_BOVIN 94.470 0.853755 1.1659 MPTX - Mucosal pentraxin precursor - Bos taurus (Bovine) - MPTX gene extracellular space, complement component C1q complex binding, low-density lipoprotein particle binding, complement activation, classical pathway, innate immune response, negative regulation by host of viral process Indicus|evm.model.CM009493.1.128 P52301 RAN_XENLA 74.737 0.851852 0.5 ran - GTP-binding nuclear protein Ran - Xenopus laevis (African clawed frog) - ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:8413630). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446). Required for normal progress through mitosis (By similarity). In concert with nemp1a/b, required for proper eye development (PubMed:25946333). Indicus|evm.model.CM009493.1.129 Q9GLX0 ACKR1_BOVIN 99.697 0.993958 1.00303 ACKR1 - Atypical chemokine receptor 1 - Bos taurus (Bovine) - ACKR1 gene Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity). Indicus|evm.model.CM009493.1.130 Q8N126 CADM3_HUMAN 95.729 0.994962 0.997487 CADM3 - Cell adhesion molecule 3 precursor - Homo sapiens (Human) - CADM3 gene Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). Indicus|evm.model.CM009493.1.132 P0DOV2 IFI4_MOUSE 58.824 0.388889 0.843296 Ifi204 - Interferon-activable protein 204 - Mus musculus (Mouse) - Ifi204 gene Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation. Indicus|evm.model.CM009493.1.134 Q96KK4 O10C1_HUMAN 47.525 0.942857 1.00962 OR10C1 - Olfactory receptor 10C1 - Homo sapiens (Human) - OR10C1 gene Odorant receptor. Indicus|evm.model.CM009493.1.135 Q8NGY3 OR6K3_HUMAN 79.811 0.972308 0.981873 OR6K3 - Olfactory receptor 6K3 - Homo sapiens (Human) - OR6K3 gene Odorant receptor. Indicus|evm.model.CM009493.1.136 P02549 SPTA1_HUMAN 74.606 0.998718 0.967755 SPTA1 - Spectrin alpha chain, erythrocytic 1 - Homo sapiens (Human) - SPTA1 gene Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Indicus|evm.model.CM009493.1.137 Q8NGY0 O10X1_HUMAN 79.641 0.927374 0.54908 OR10X1 - Olfactory receptor 10X1 - Homo sapiens (Human) - OR10X1 gene Odorant receptor. Indicus|evm.model.CM009493.1.138 Q8NGY0 O10X1_HUMAN 82.581 0.953704 0.993865 OR10X1 - Olfactory receptor 10X1 - Homo sapiens (Human) - OR10X1 gene Odorant receptor. Indicus|evm.model.CM009493.1.139 Q71U00 SKP1_XENLA 99.387 0.987805 1.00613 skp1 - S-phase kinase-associated protein 1 - Xenopus laevis (African clawed frog) - skp1 gene Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). Indicus|evm.model.CM009493.1.140 Q9XS72 CD1A_PIG 71.429 0.919614 0.917404 CD1A - T-cell surface glycoprotein CD1a precursor - Sus scrofa (Pig) - CD1A gene Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Indicus|evm.model.CM009493.1.141 Q8NGX3 O10T2_HUMAN 95.918 0.986486 0.471338 OR10T2 - Olfactory receptor 10T2 - Homo sapiens (Human) - OR10T2 gene Odorant receptor. Indicus|evm.model.CM009493.1.142 P15812 CD1E_HUMAN 69.110 0.971795 1.00515 CD1E - T-cell surface glycoprotein CD1e, membrane-associated precursor - Homo sapiens (Human) - CD1E gene T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. Indicus|evm.model.CM009493.1.143 P80943 CD1B3_SHEEP 90.769 0.655405 1.27586 T-cell surface glycoprotein CD1b-3 - Ovis aries (Sheep) Indicus|evm.model.CM009493.1.144 Q28565 CD1B1_SHEEP 85.561 0.572308 0.975976 T-cell surface glycoprotein CD1b-1 precursor - Ovis aries (Sheep) Indicus|evm.model.CM009493.1.145 Q29422 CD1B2_SHEEP 91.167 0.946108 1.003 T-cell surface glycoprotein CD1b-2 precursor - Ovis aries (Sheep) Indicus|evm.model.CM009493.1.146 P80943 CD1B3_SHEEP 90.000 0.71134 0.418103 T-cell surface glycoprotein CD1b-3 - Ovis aries (Sheep) Indicus|evm.model.CM009493.1.147 Q9XS72 CD1A_PIG 70.159 0.831551 1.10324 CD1A - T-cell surface glycoprotein CD1a precursor - Sus scrofa (Pig) - CD1A gene Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Indicus|evm.model.CM009493.1.148 O62848 CD1D_SHEEP 86.513 0.405622 2.22985 CD1D - Antigen-presenting glycoprotein CD1d precursor - Ovis aries (Sheep) - CD1D gene Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. Indicus|evm.model.CM009493.1.149 O62848 CD1D_SHEEP 90.957 0.984211 0.567164 CD1D - Antigen-presenting glycoprotein CD1d precursor - Ovis aries (Sheep) - CD1D gene Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. Indicus|evm.model.CM009493.1.150 O62848 CD1D_SHEEP 81.081 0.755708 1.30746 CD1D - Antigen-presenting glycoprotein CD1d precursor - Ovis aries (Sheep) - CD1D gene Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. Indicus|evm.model.CM009493.1.151 Q96J84 KIRR1_HUMAN 95.497 0.984085 0.996037 KIRREL1 - Kin of IRRE-like protein 1 precursor - Homo sapiens (Human) - KIRREL1 gene Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). Indicus|evm.model.CM009493.1.152 O43866 CD5L_HUMAN 68.571 0.189781 1.57925 CD5L - CD5 antigen-like precursor - Homo sapiens (Human) - CD5L gene Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983). Indicus|evm.model.CM009493.1.154 Q96LA6 FCRL1_HUMAN 64.232 0.994975 0.927739 FCRL1 - Fc receptor-like protein 1 precursor - Homo sapiens (Human) - FCRL1 gene May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. Indicus|evm.model.CM009493.1.155 Q96P31 FCRL3_HUMAN 60.458 0.881971 1.05041 FCRL3 - Fc receptor-like protein 3 precursor - Homo sapiens (Human) - FCRL3 gene Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275). Indicus|evm.model.CM009493.1.156 Q96LA5 FCRL2_HUMAN 57.143 0.142346 2.19882 FCRL2 - Fc receptor-like protein 2 precursor - Homo sapiens (Human) - FCRL2 gene May have an regulatory role in normal and neoplastic B cell development. Indicus|evm.model.CM009493.1.157 Q96RD9 FCRL5_HUMAN 69.565 0.514124 0.181167 FCRL5 - Fc receptor-like protein 5 precursor - Homo sapiens (Human) - FCRL5 gene May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. Indicus|evm.model.CM009493.1.160 Q5RKI1 IF4A2_RAT 73.590 0.993691 0.77887 Eif4a2 - Eukaryotic initiation factor 4A-II - Rattus norvegicus (Rat) - Eif4a2 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Indicus|evm.model.CM009493.1.167 P50397 GDIB_BOVIN 92.149 0.99177 0.546067 GDI2 - Rab GDP dissociation inhibitor beta - Bos taurus (Bovine) - GDI2 gene Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Indicus|evm.model.CM009493.1.169 A1YF15 ETV3_GORGO 91.797 0.996078 0.996094 ETV3 - ETS translocation variant 3 - Gorilla gorilla gorilla (Western lowland gorilla) - ETV3 gene Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity (By similarity). Indicus|evm.model.CM009493.1.171 Q8R4Z4 ETV3_MOUSE 89.831 0.325905 0.699805 Etv3 - ETS translocation variant 3 - Mus musculus (Mouse) - Etv3 gene Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. Indicus|evm.model.CM009493.1.172 O15085 ARHGB_HUMAN 85.915 0.998711 1.01905 ARHGEF11 - Rho guanine nucleotide exchange factor 11 - Homo sapiens (Human) - ARHGEF11 gene May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. Indicus|evm.model.CM009493.1.173 Q8N4P6 LRC71_HUMAN 84.119 0.991304 1.02862 LRRC71 - Leucine-rich repeat-containing protein 71 - Homo sapiens (Human) - LRRC71 gene Indicus|evm.model.CM009493.1.174 Q5VY43 PEAR1_HUMAN 88.074 0.981748 1.00386 PEAR1 - Platelet endothelial aggregation receptor 1 precursor - Homo sapiens (Human) - PEAR1 gene When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. Indicus|evm.model.CM009493.1.175 P04629 NTRK1_HUMAN 92.839 0.997487 1 NTRK1 - High affinity nerve growth factor receptor precursor - Homo sapiens (Human) - NTRK1 gene Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Indicus|evm.model.CM009493.1.176 P14616 INSRR_HUMAN 93.236 0.998464 1.00386 INSRR - Insulin receptor-related protein precursor - Homo sapiens (Human) - INSRR gene Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Indicus|evm.model.CM009493.1.177 Q9NP31 SH22A_HUMAN 73.031 0.995227 1.07712 SH2D2A - SH2 domain-containing protein 2A - Homo sapiens (Human) - SH2D2A gene Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. Indicus|evm.model.CM009493.1.178 Q92733 PRCC_HUMAN 97.561 0.995943 1.00407 PRCC - Proline-rich protein PRCC - Homo sapiens (Human) - PRCC gene May regulate cell cycle progression through interaction with MAD2L2. Indicus|evm.model.CM009493.1.179 Q9XSK7 HDGF_BOVIN 100.000 0.496842 1.98745 HDGF - Hepatoma-derived growth factor - Bos taurus (Bovine) - HDGF gene Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity). Indicus|evm.model.CM009493.1.180 Q5E9V4 RRNAD_BOVIN 99.789 0.995798 1.00211 RRNAD1 - Protein RRNAD1 - Bos taurus (Bovine) - RRNAD1 gene Indicus|evm.model.CM009493.1.181 Q2YDK1 I20L2_BOVIN 99.713 0.994286 1.00287 ISG20L2 - Interferon-stimulated 20 kDa exonuclease-like 2 - Bos taurus (Bovine) - ISG20L2 gene 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group. Indicus|evm.model.CM009493.1.182 Q5PXY7 RABP2_BOVIN 99.275 0.985612 1.00725 CRABP2 - Cellular retinoic acid-binding protein 2 - Bos taurus (Bovine) - CRABP2 gene Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors (By similarity). Indicus|evm.model.CM009493.1.183 P48681 NEST_HUMAN 61.963 0.995199 0.899445 NES - Nestin - Homo sapiens (Human) - NES gene Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Indicus|evm.model.CM009493.1.184 Q28062 PGCB_BOVIN 99.561 0.997809 1.0011 BCAN - Brevican core protein precursor - Bos taurus (Bovine) - BCAN gene May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Indicus|evm.model.CM009493.1.185 Q9GZV7 HPLN2_HUMAN 92.059 0.994135 1.00294 HAPLN2 - Hyaluronan and proteoglycan link protein 2 precursor - Homo sapiens (Human) - HAPLN2 gene Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity). Indicus|evm.model.CM009493.1.186 Q2KJE1 GPTC4_BOVIN 98.044 0.914798 1.09314 GPATCH4 - G patch domain-containing protein 4 - Bos taurus (Bovine) - GPATCH4 gene Indicus|evm.model.CM009493.1.187 Q6QRN6 NNRE_BOVIN 100.000 0.99308 1.00347 NAXE - NAD(P)H-hydrate epimerase precursor - Bos taurus (Bovine) - NAXE gene Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity). Indicus|evm.model.CM009493.1.188 A2A3L6 TTC24_HUMAN 71.993 0.99631 0.931271 TTC24 - Tetratricopeptide repeat protein 24 - Homo sapiens (Human) - TTC24 gene Indicus|evm.model.CM009493.1.189 Q86VI3 IQGA3_HUMAN 89.400 0.99876 0.988964 IQGAP3 - Ras GTPase-activating-like protein IQGAP3 - Homo sapiens (Human) - IQGAP3 gene cytoplasm, cytosol, actin filament binding, calmodulin binding, GTPase activator activity, myosin VI light chain binding, regulation of actin cytoskeleton organization Indicus|evm.model.CM009493.1.190 Q56K03 RL27A_BOVIN 97.297 0.986577 1.00676 RPL27A - 60S ribosomal protein L27a - Bos taurus (Bovine) - RPL27A gene cytosolic large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009493.1.191 O89038 MEF2D_RAT 94.675 0.996063 1.00197 Mef2d - Myocyte-specific enhancer factor 2D - Rattus norvegicus (Rat) - Mef2d gene Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). Indicus|evm.model.CM009493.1.193 Q95M77 RHBG_BOVIN 100.000 0.995614 1.0022 RHBG - Ammonium transporter Rh type B - Bos taurus (Bovine) - RHBG gene Functions as a specific ammonium transporter. Indicus|evm.model.CM009493.1.194 Q3T016 TSACC_BOVIN 99.200 0.984127 1.008 TSACC - TSSK6-activating co-chaperone protein - Bos taurus (Bovine) - TSACC gene Co-chaperone that facilitates HSP-mediated activation of TSSK6. Indicus|evm.model.CM009493.1.195 Q3T0K2 TCPG_BOVIN 100.000 0.996337 1.00183 CCT3 - T-complex protein 1 subunit gamma - Bos taurus (Bovine) - CCT3 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.CM009493.1.196 Q0P5L7 GLMP_BOVIN 99.505 0.995062 1.00248 GLMP - Glycosylated lysosomal membrane protein precursor - Bos taurus (Bovine) - GLMP gene Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. Indicus|evm.model.CM009493.1.197 Q5E9U3 TMM79_BOVIN 100.000 0.994949 1.00253 TMEM79 - Transmembrane protein 79 - Bos taurus (Bovine) - TMEM79 gene Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity). Indicus|evm.model.CM009493.1.198 Q9UPR3 SMG5_HUMAN 96.161 0.998033 1.00098 SMG5 - Protein SMG5 - Homo sapiens (Human) - SMG5 gene Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. Indicus|evm.model.CM009493.1.199 Q6TCH4 PAQR6_HUMAN 92.121 0.713666 1.34012 PAQR6 - Membrane progestin receptor delta - Homo sapiens (Human) - PAQR6 gene Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870). Indicus|evm.model.CM009493.1.200 P02820 OSTCN_BOVIN 100.000 0.980198 1.01 BGLAP - Osteocalcin precursor - Bos taurus (Bovine) - BGLAP gene Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Indicus|evm.model.CM009493.1.201 Q2T9N4 PMF1_BOVIN 100.000 0.990291 1.00488 PMF1 - Polyamine-modulated factor 1 - Bos taurus (Bovine) - PMF1 gene Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT (By similarity). Indicus|evm.model.CM009493.1.202 Q5RD67 S2544_PONAB 99.045 0.993651 1.00318 SLC25A44 - Solute carrier family 25 member 44 - Pongo abelii (Sumatran orangutan) - SLC25A44 gene Mitochondrial solute transporter which transports branched-chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis. Indicus|evm.model.CM009493.1.203 Q5EA85 SEM4A_BOVIN 99.869 0.997379 1.00131 SEMA4A - Semaphorin-4A precursor - Bos taurus (Bovine) - SEMA4A gene Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity). Indicus|evm.model.CM009493.1.204 Q3ZD69 LMNA_PIG 97.744 0.996992 1.00151 LMNA - Prelamin-A/C precursor - Sus scrofa (Pig) - LMNA gene Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (By similarity). Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone. Required for cardiac homeostasis. Indicus|evm.model.CM009493.1.205 A1L020 MEX3A_HUMAN 98.005 0.987654 0.778846 MEX3A - RNA-binding protein MEX3A - Homo sapiens (Human) - MEX3A gene RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. Indicus|evm.model.CM009493.1.206 Q58DW6 RAB25_BOVIN 100.000 0.990654 1.00469 RAB25 - Ras-related protein Rab-25 precursor - Bos taurus (Bovine) - RAB25 gene Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). Indicus|evm.model.CM009493.1.207 Q9Y2Q5 LTOR2_HUMAN 100.000 0.984127 1.008 LAMTOR2 - Ragulator complex protein LAMTOR2 - Homo sapiens (Human) - LAMTOR2 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. Indicus|evm.model.CM009493.1.208 Q9NRR5 UBQL4_HUMAN 96.173 0.996678 1.00166 UBQLN4 - Ubiquilin-4 - Homo sapiens (Human) - UBQLN4 gene Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). Indicus|evm.model.CM009493.1.209 Q6ZN17 LN28B_HUMAN 59.434 0.617834 0.628 LIN28B - Protein lin-28 homolog B - Homo sapiens (Human) - LIN28B gene Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. Indicus|evm.model.CM009493.1.211 Q5E9E4 SSRB_BOVIN 100.000 0.973262 1.02186 SSR2 - Translocon-associated protein subunit beta precursor - Bos taurus (Bovine) - SSR2 gene TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Indicus|evm.model.CM009493.1.212 B2DCZ9 ARHG2_PIG 96.881 0.80251 1.2435 ARHGEF2 - Rho guanine nucleotide exchange factor 2 - Sus scrofa (Pig) - ARHGEF2 gene Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability. Involved in neuronal progenitor cell division and differentiation. Involved in the migration of precerebellar neurons. Indicus|evm.model.CM009493.1.213 Q8TDU9 RL3R2_HUMAN 85.561 0.994652 1 RXFP4 - Relaxin-3 receptor 2 - Homo sapiens (Human) - RXFP4 gene High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation. Indicus|evm.model.CM009493.1.214 Q92963 RIT1_HUMAN 99.087 0.265931 3.72603 RIT1 - GTP-binding protein Rit1 - Homo sapiens (Human) - RIT1 gene Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. Indicus|evm.model.CM009493.1.215 Q9BT88 SYT11_HUMAN 96.984 0.99536 1 SYT11 - Synaptotagmin-11 - Homo sapiens (Human) - SYT11 gene Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822). Indicus|evm.model.CM009493.1.217 Q3T8J9 GON4L_HUMAN 85.587 0.999107 0.999554 GON4L - GON-4-like protein - Homo sapiens (Human) - GON4L gene Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis. Indicus|evm.model.CM009493.1.218 A5D9D4 MSTO1_BOVIN 100.000 0.99651 1.00175 MSTO1 - Protein misato homolog 1 - Bos taurus (Bovine) - MSTO1 gene Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation. Indicus|evm.model.CM009493.1.219 P82922 RT29_BOVIN 100.000 0.569784 1.75063 DAP3 - 28S ribosomal protein S29, mitochondrial precursor - Bos taurus (Bovine) - DAP3 gene Involved in mediating interferon-gamma-induced cell death. Indicus|evm.model.CM009493.1.220 Q9NR48 ASH1L_HUMAN 95.657 0.999326 0.99899 ASH1L - Histone-lysine N-methyltransferase ASH1L - Homo sapiens (Human) - ASH1L gene Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). Indicus|evm.model.CM009493.1.221 Q9BVN2 RUSC1_HUMAN 88.027 0.430489 1.15632 RUSC1 - RUN and SH3 domain-containing protein 1 - Homo sapiens (Human) - RUSC1 gene Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. Indicus|evm.model.CM009493.1.222 Q8WMY2 FPPS_BOVIN 100.000 0.826291 1.2068 FDPS - Farnesyl pyrophosphate synthase - Bos taurus (Bovine) - FDPS gene Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). Indicus|evm.model.CM009493.1.223 P30613 KPYR_HUMAN 92.471 0.981025 0.918118 PKLR - Pyruvate kinase PKLR - Homo sapiens (Human) - PKLR gene Plays a key role in glycolysis. Indicus|evm.model.CM009493.1.224 Q9P1Z3 HCN3_HUMAN 95.402 0.997449 1.01292 HCN3 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 - Homo sapiens (Human) - HCN3 gene Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. Indicus|evm.model.CM009493.1.225 P49760 CLK2_HUMAN 99.000 0.996008 1.00401 CLK2 - Dual specificity protein kinase CLK2 - Homo sapiens (Human) - CLK2 gene Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). Indicus|evm.model.CM009493.1.226 Q58DR5 SCAM3_BOVIN 99.424 0.994253 1.00288 SCAMP3 - Secretory carrier-associated membrane protein 3 - Bos taurus (Bovine) - SCAMP3 gene Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity). Indicus|evm.model.CM009493.1.227 P81408 F189B_HUMAN 95.808 0.99701 1.0015 FAM189B - Protein FAM189B - Homo sapiens (Human) - FAM189B gene WW domain binding Indicus|evm.model.CM009493.1.228 Q2KHZ8 GLCM_BOVIN 99.813 0.996276 1.00187 GBA - Lysosomal acid glucosylceramidase precursor - Bos taurus (Bovine) - GBA gene Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol. Indicus|evm.model.CM009493.1.229 Q2TBS1 MTX1_BOVIN 99.685 0.678112 1.47003 MTX1 - Metaxin-1 - Bos taurus (Bovine) - MTX1 gene Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity). Indicus|evm.model.CM009493.1.230 P49746 TSP3_HUMAN 97.490 0.99791 1.00105 THBS3 - Thrombospondin-3 precursor - Homo sapiens (Human) - THBS3 gene Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Indicus|evm.model.CM009493.1.231 Q8WML4 MUC1_BOVIN 99.203 0.781591 1.10517 MUC1 - Mucin-1 precursor - Bos taurus (Bovine) - MUC1 gene The alpha subunit has cell adhesive properties. May provide a protective layer on epithelial cells against bacterial and enzyme attack (By similarity). Indicus|evm.model.CM009493.1.232 Q7Z4K8 TRI46_HUMAN 98.551 0.940447 1.06192 TRIM46 - Tripartite motif-containing protein 46 - Homo sapiens (Human) - TRIM46 gene Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration. Indicus|evm.model.CM009493.1.233 A6QQ59 KTAP2_BOVIN 100.000 0.978261 1.01471 KRTCAP2 - Keratinocyte-associated protein 2 - Bos taurus (Bovine) - KRTCAP2 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. Indicus|evm.model.CM009493.1.234 Q3ZC71 DPM3_BOVIN 100.000 0.978495 1.01087 DPM3 - Dolichol-phosphate mannosyltransferase subunit 3 - Bos taurus (Bovine) - DPM3 gene Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER. Indicus|evm.model.CM009493.1.235 Q3ZC64 EFNA1_BOVIN 100.000 0.503704 1.97561 EFNA1 - Ephrin-A1 precursor - Bos taurus (Bovine) - EFNA1 gene Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity). Indicus|evm.model.CM009493.1.236 P52797 EFNA3_HUMAN 98.319 0.991632 1.0042 EFNA3 - Ephrin-A3 precursor - Homo sapiens (Human) - EFNA3 gene Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). Indicus|evm.model.CM009493.1.237 P52798 EFNA4_HUMAN 79.787 0.912195 1.0199 EFNA4 - Ephrin-A4 precursor - Homo sapiens (Human) - EFNA4 gene Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. Indicus|evm.model.CM009493.1.238 Q13444 ADA15_HUMAN 82.726 0.980392 1.00463 ADAM15 - Disintegrin and metalloproteinase domain-containing protein 15 precursor - Homo sapiens (Human) - ADAM15 gene Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Indicus|evm.model.CM009493.1.239 Q5T197 DCST1_HUMAN 82.128 0.995745 0.998584 DCST1 - E3 ubiquitin-protein ligase DCST1 - Homo sapiens (Human) - DCST1 gene E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. Indicus|evm.model.CM009493.1.240 Q5T1A1 DCST2_HUMAN 84.056 0.995816 0.927555 DCST2 - DC-STAMP domain-containing protein 2 - Homo sapiens (Human) - DCST2 gene Indicus|evm.model.CM009493.1.241 O15156 ZBT7B_HUMAN 92.804 0.996289 1 ZBTB7B - Zinc finger and BTB domain-containing protein 7B - Homo sapiens (Human) - ZBTB7B gene Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). Indicus|evm.model.CM009493.1.242 Q9Y5L5 LENEP_HUMAN 88.525 0.454545 2.16393 LENEP - Lens epithelial cell protein LEP503 - Homo sapiens (Human) - LENEP gene May play a role in lens epithelial cell differentiation. Indicus|evm.model.CM009493.1.243 Q8NFF5 FAD1_HUMAN 91.111 0.867955 1.05792 FLAD1 - FAD synthase precursor - Homo sapiens (Human) - FLAD1 gene Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Indicus|evm.model.CM009493.1.244 Q0IIE2 SHC1_BOVIN 100.000 0.808219 1.23467 SHC1 - SHC-transforming protein 1 - Bos taurus (Bovine) - SHC1 gene Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Indicus|evm.model.CM009493.1.246 A6QLY7 PBIP1_BOVIN 99.587 0.878935 1.13618 PBXIP1 - Pre-B-cell leukemia transcription factor-interacting protein 1 - Bos taurus (Bovine) - PBXIP1 gene Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity). Indicus|evm.model.CM009493.1.247 Q2KIU2 PMVK_BOVIN 100.000 0.989637 1.00521 PMVK - Phosphomevalonate kinase - Bos taurus (Bovine) - PMVK gene Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites. Indicus|evm.model.CM009493.1.248 P58392 KCNN3_PIG 98.619 0.99723 0.997238 KCNN3 - Small conductance calcium-activated potassium channel protein 3 - Sus scrofa (Pig) - KCNN3 gene Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity). Indicus|evm.model.CM009493.1.249 P55265 DSRAD_HUMAN 79.462 0.998261 0.93801 ADAR - Double-stranded RNA-specific adenosine deaminase - Homo sapiens (Human) - ADAR gene Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:7972084, PubMed:7565688, PubMed:12618436). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. Indicus|evm.model.CM009493.1.250 P17787 ACHB2_HUMAN 92.032 0.996016 1 CHRNB2 - Neuronal acetylcholine receptor subunit beta-2 precursor - Homo sapiens (Human) - CHRNB2 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. Indicus|evm.model.CM009493.1.251 Q7Z7E8 UB2Q1_HUMAN 100.000 0.956298 0.921801 UBE2Q1 - Ubiquitin-conjugating enzyme E2 Q1 - Homo sapiens (Human) - UBE2Q1 gene Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). Indicus|evm.model.CM009493.1.252 Q5VZ19 TDR10_HUMAN 74.468 0.910405 0.945355 TDRD10 - Tudor domain-containing protein 10 - Homo sapiens (Human) - TDRD10 gene Indicus|evm.model.CM009493.1.253 Q5VZ18 SHE_HUMAN 88.976 0.969407 1.05657 SHE - SH2 domain-containing adapter protein E - Homo sapiens (Human) - SHE gene phosphotyrosine residue binding Indicus|evm.model.CM009493.1.254 O18796 IL6RA_PIG 79.915 0.995699 0.995717 IL6R - Interleukin-6 receptor subunit alpha precursor - Sus scrofa (Pig) - IL6R gene Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. Indicus|evm.model.CM009493.1.255 P98198 AT8B2_HUMAN 97.981 0.966558 1.01406 ATP8B2 - Phospholipid-transporting ATPase ID - Homo sapiens (Human) - ATP8B2 gene Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry. Indicus|evm.model.CM009493.1.256 Q96PS8 AQP10_HUMAN 70.270 0.989209 0.923588 AQP10 - Aquaporin-10 - Homo sapiens (Human) - AQP10 gene Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH (PubMed:12084581, PubMed:21733844, PubMed:23382902, PubMed:30420639). The channel is permeable to glycerol, especially when the cytosolic pH is acidified (PubMed:21733844, PubMed:30420639). Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation (PubMed:23382902). May contribute to water transport in the intestine (Probable). Indicus|evm.model.CM009493.1.257 Q2KIE2 HAX1_BOVIN 99.283 0.985816 1.01075 HAX1 - HCLS1-associated protein X-1 - Bos taurus (Bovine) - HAX1 gene Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. Indicus|evm.model.CM009493.1.258 Q14157 UBP2L_HUMAN 98.896 0.998162 1.00092 UBAP2L - Ubiquitin-associated protein 2-like - Homo sapiens (Human) - UBAP2L gene Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). Required for efficient formation of stress granules (PubMed:29395067). Indicus|evm.model.CM009493.1.259 Q5E943 CA043_BOVIN 100.000 0.992126 1.00395 Protein C1orf43 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009493.1.260 Q32L75 CA189_BOVIN 100.000 0.980392 1.0099 Uncharacterized protein C1orf189 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009493.1.261 Q5KR47 TPM3_BOVIN 87.676 0.992982 1.00352 TPM3 - Tropomyosin alpha-3 chain - Bos taurus (Bovine) - TPM3 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Indicus|evm.model.CM009493.1.262 Q5VU65 P210L_HUMAN 90.086 0.983024 0.998411 NUP210L - Nuclear pore membrane glycoprotein 210-like precursor - Homo sapiens (Human) - NUP210L gene nuclear pore Indicus|evm.model.CM009493.1.263 Q71TY3 RS27_RAT 100.000 0.976471 1.0119 Rps27 - 40S ribosomal protein S27 - Rattus norvegicus (Rat) - Rps27 gene Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity). Indicus|evm.model.CM009493.1.264 Q6Q311 RS25_SHEEP 100.000 0.984127 1.008 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Indicus|evm.model.CM009493.1.265 Q58DS5 RAB13_BOVIN 99.507 0.990196 1.00493 RAB13 - Ras-related protein Rab-13 precursor - Bos taurus (Bovine) - RAB13 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis (By similarity). Indicus|evm.model.CM009493.1.266 O76095 JTB_HUMAN 89.726 0.986395 1.00685 JTB - Protein JTB precursor - Homo sapiens (Human) - JTB gene Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). Indicus|evm.model.CM009493.1.267 Q8TEY5 CR3L4_HUMAN 81.772 0.98 1.01266 CREB3L4 - Cyclic AMP-responsive element-binding protein 3-like protein 4 - Homo sapiens (Human) - CREB3L4 gene Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). Indicus|evm.model.CM009493.1.268 Q3SYU3 S39A1_BOVIN 100.000 0.993846 1.00309 SLC39A1 - Zinc transporter ZIP1 - Bos taurus (Bovine) - SLC39A1 gene Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body (By similarity). Indicus|evm.model.CM009493.1.269 Q08E26 CRTC2_BOVIN 96.910 0.997195 1.02886 CRTC2 - CREB-regulated transcription coactivator 2 - Bos taurus (Bovine) - CRTC2 gene Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). Indicus|evm.model.CM009493.1.270 O75064 DEN4B_HUMAN 100.000 0.821705 0.0862299 DENND4B - DENN domain-containing protein 4B - Homo sapiens (Human) - DENND4B gene Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Indicus|evm.model.CM009493.1.271 O75064 DEN4B_HUMAN 93.404 0.99429 0.819519 DENND4B - DENN domain-containing protein 4B - Homo sapiens (Human) - DENND4B gene Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Indicus|evm.model.CM009493.1.272 Q8WXI9 P66B_HUMAN 99.157 0.996627 1 GATAD2B - Transcriptional repressor p66-beta - Homo sapiens (Human) - GATAD2B gene Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. Indicus|evm.model.CM009493.1.274 Q5K4L6 S27A3_HUMAN 88.502 0.963127 0.992679 SLC27A3 - Solute carrier family 27 member 3 - Homo sapiens (Human) - SLC27A3 gene Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (PubMed:23936004). Does not exhibit fatty acid transport activity (By similarity). Indicus|evm.model.CM009493.1.275 Q68E01 INT3_HUMAN 99.137 0.998079 0.998082 INTS3 - Integrator complex subunit 3 - Homo sapiens (Human) - INTS3 gene Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Indicus|evm.model.CM009493.1.276 P16066 ANPRA_HUMAN 92.931 0.998111 0.998115 NPR1 - Atrial natriuretic peptide receptor 1 precursor - Homo sapiens (Human) - NPR1 gene Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. Indicus|evm.model.CM009493.1.277 Q5RFJ1 ILF2_PONAB 100.000 0.994885 1.00256 ILF2 - Interleukin enhancer-binding factor 2 - Pongo abelii (Sumatran orangutan) - ILF2 gene Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). Essential for the efficient reshuttling of ILF3 into the nucleus (By similarity). Indicus|evm.model.CM009493.1.278 P60192 SNAPN_RAT 97.794 0.985401 1.00735 Snapin - SNARE-associated protein Snapin - Rattus norvegicus (Rat) - Snapin gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:10195194, PubMed:11283605). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). Indicus|evm.model.CM009493.1.279 P02639 S10A1_BOVIN 100.000 0.163386 5.40426 S100A1 - Protein S100-A1 - Bos taurus (Bovine) - S100A1 gene Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole. Indicus|evm.model.CM009493.1.280 P79342 S10AD_BOVIN 100.000 0.668966 1.47959 S100A13 - Protein S100-A13 - Bos taurus (Bovine) - S100A13 gene Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). Indicus|evm.model.CM009493.1.281 Q3MHP3 S10AE_BOVIN 100.000 0.980952 1.00962 S100A14 - Protein S100-A14 - Bos taurus (Bovine) - S100A14 gene Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity). Indicus|evm.model.CM009493.1.282 Q0VCM0 S10AG_BOVIN 100.000 0.980769 1.00971 S100A16 - Protein S100-A16 - Bos taurus (Bovine) - S100A16 gene Calcium-binding protein. Binds one calcium ion per monomer (By similarity). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity). Indicus|evm.model.CM009493.1.283 P10462 S10A2_BOVIN 100.000 0.979592 1.01031 S100A2 - Protein S100-A2 - Bos taurus (Bovine) - S100A2 gene May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth (By similarity). Indicus|evm.model.CM009493.1.284 P33764 S10A3_HUMAN 67.327 0.98 0.990099 S100A3 - Protein S100-A3 - Homo sapiens (Human) - S100A3 gene Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. Indicus|evm.model.CM009493.1.285 P35466 S10A4_BOVIN 100.000 0.980392 1.0099 S100A4 - Protein S100-A4 - Bos taurus (Bovine) - S100A4 gene Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (By similarity). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity). Indicus|evm.model.CM009493.1.286 P33763 S10A5_HUMAN 95.652 0.494565 2 S100A5 - Protein S100-A5 - Homo sapiens (Human) - S100A5 gene Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. Indicus|evm.model.CM009493.1.287 Q28050 S10A7_BOVIN 100.000 0.980392 1.0099 S100A7 - Protein S100-A7 - Bos taurus (Bovine) - S100A7 gene extracellular space, calcium ion binding, calcium-dependent protein binding Indicus|evm.model.CM009493.1.288 P54762 EPHB1_HUMAN 77.381 0.987755 0.248984 EPHB1 - Ephrin type-B receptor 1 precursor - Homo sapiens (Human) - EPHB1 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). Indicus|evm.model.CM009493.1.290 Q28050 S10A7_BOVIN 93.069 0.980392 1.0099 S100A7 - Protein S100-A7 - Bos taurus (Bovine) - S100A7 gene extracellular space, calcium ion binding, calcium-dependent protein binding Indicus|evm.model.CM009493.1.291 A7K6Y9 S115A_PONAB 86.111 0.981651 1.00926 S100A15A - Protein S100-A15A - Pongo abelii (Sumatran orangutan) - S100A15A gene Indicus|evm.model.CM009493.1.292 P28782 S10A8_BOVIN 100.000 0.977778 1.01124 S100A8 - Protein S100-A8 - Bos taurus (Bovine) - S100A8 gene S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants (By similarity). The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity (By similarity). Indicus|evm.model.CM009493.1.293 P79105 S10AC_BOVIN 97.826 0.978495 1.01087 S100A12 - Protein S100-A12 - Bos taurus (Bovine) - S100A12 gene S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites (By similarity). Indicus|evm.model.CM009493.1.294 P28783 S10A9_BOVIN 98.718 0.987261 1.00641 S100A9 - Protein S100-A9 - Bos taurus (Bovine) - S100A9 gene S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, NXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif. Indicus|evm.model.CM009493.1.295 Q96LB8 PGRP4_HUMAN 74.924 0.90884 0.970509 PGLYRP4 - Peptidoglycan recognition protein 4 precursor - Homo sapiens (Human) - PGLYRP4 gene Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. Indicus|evm.model.CM009493.1.296 Q96LB9 PGRP3_HUMAN 79.128 0.846561 1.1085 PGLYRP3 - Peptidoglycan recognition protein 3 precursor - Homo sapiens (Human) - PGLYRP3 gene Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. Indicus|evm.model.CM009493.1.307 Q28658 SPRR3_RABIT 63.333 0.82243 0.463203 SPRR3 - Small proline-rich protein 3 - Oryctolagus cuniculus (Rabbit) - SPRR3 gene Can serve as a substrate in transglutaminase-catalyzed cross linking reactions and can function as a cross-linked envelope precursor. Indicus|evm.model.CM009493.1.309 Q96PI1 SPRR4_HUMAN 87.500 0.618421 0.962025 SPRR4 - Small proline-rich protein 4 - Homo sapiens (Human) - SPRR4 gene Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification. Indicus|evm.model.CM009493.1.310 P18175 INVO_PIG 78.571 0.192635 1.01729 IVL - Involucrin - Sus scrofa (Pig) - IVL gene Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Indicus|evm.model.CM009493.1.314 O14633 LCE2B_HUMAN 67.606 0.653846 0.945455 LCE2B - Late cornified envelope protein 2B - Homo sapiens (Human) - LCE2B gene Precursors of the cornified envelope of the stratum corneum. Indicus|evm.model.CM009493.1.318 Q9D662 SC23B_MOUSE 89.655 0.37013 0.200782 Sec23b - Protein transport protein Sec23B - Mus musculus (Mouse) - Sec23b gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Indicus|evm.model.CM009493.1.319 Q3SZN2 SC23B_BOVIN 84.564 0.870588 0.221643 SEC23B - Protein transport protein Sec23B - Bos taurus (Bovine) - SEC23B gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Indicus|evm.model.CM009493.1.320 Q7Z434 MAVS_HUMAN 61.538 0.922619 0.311111 MAVS - Mitochondrial antiviral-signaling protein - Homo sapiens (Human) - MAVS gene Required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:20127681, PubMed:21170385). Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:25636800, PubMed:20127681, PubMed:21170385, PubMed:20628368). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Indicus|evm.model.CM009493.1.322 Q9UBG3 CRNN_HUMAN 58.981 0.47125 1.61616 CRNN - Cornulin - Homo sapiens (Human) - CRNN gene Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 (PubMed:30009832). Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways (PubMed:30009832). Indicus|evm.model.CM009493.1.323 Q5D862 FILA2_HUMAN 79.638 0.386643 0.237976 FLG2 - Filaggrin-2 - Homo sapiens (Human) - FLG2 gene Essential for normal cell-cell adhesion in the cornified cell layers (PubMed:29758285). Important for proper integrity and mechanical strength of the stratum corneum of the epidermis (PubMed:29505760). Indicus|evm.model.CM009493.1.324 Q2VIS4 FILA2_MOUSE 51.485 0.06035 0.701524 Flg2 - Filaggrin-2 - Mus musculus (Mouse) - Flg2 gene Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. Indicus|evm.model.CM009493.1.325 Q86YZ3 HORN_HUMAN 79.612 0.376384 0.0950877 HRNR - Hornerin - Homo sapiens (Human) - HRNR gene Component of the epidermal cornified cell envelopes. Indicus|evm.model.CM009493.1.326 Q6XPR3 RPTN_HUMAN 65.000 0.48037 1.65689 RPTN - Repetin - Homo sapiens (Human) - RPTN gene Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium. Indicus|evm.model.CM009493.1.327 P22793 TRHY_SHEEP 73.472 0.435336 0.913493 TCHH - Trichohyalin - Ovis aries (Sheep) - TCHH gene Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. Indicus|evm.model.CM009493.1.328 A6QP92 TCHL1_BOVIN 99.885 0.997709 1.00115 TCHHL1 - Trichohyalin-like protein 1 - Bos taurus (Bovine) - TCHHL1 gene Indicus|evm.model.CM009493.1.329 Q6XPR3 RPTN_HUMAN 51.190 0.0710616 1.4898 RPTN - Repetin - Homo sapiens (Human) - RPTN gene Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium. Indicus|evm.model.CM009493.1.330 Q6SQH4 S10AA_RABIT 100.000 0.761905 1.29897 S100a10 - Protein S100-A10 - Oryctolagus cuniculus (Rabbit) - S100a10 gene Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. Indicus|evm.model.CM009493.1.331 A1A4L1 THEM4_BOVIN 85.232 0.990196 0.860759 THEM4 - Acyl-coenzyme A thioesterase THEM4 precursor - Bos taurus (Bovine) - THEM4 gene Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity). Indicus|evm.model.CM009493.1.332 P29475 NOS1_HUMAN 93.846 0.412903 0.108089 NOS1 - Nitric oxide synthase, brain - Homo sapiens (Human) - NOS1 gene Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Indicus|evm.model.CM009493.1.333 Q9CQJ0 THEM5_MOUSE 70.565 0.991968 1.00403 Them5 - Acyl-coenzyme A thioesterase THEM5 - Mus musculus (Mouse) - Them5 gene Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (By similarity). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271). Required for normal mitochondrial function (PubMed:22586271). Indicus|evm.model.CM009493.1.334 P51449 RORG_HUMAN 90.154 0.996146 1.00193 RORC - Nuclear receptor ROR-gamma - Homo sapiens (Human) - RORC gene Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC1 and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376). Indicus|evm.model.CM009493.1.335 Q6UY18 LIGO4_HUMAN 92.088 0.996639 1.00337 LINGO4 - Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 precursor - Homo sapiens (Human) - LINGO4 gene extracellular matrix, extracellular space Indicus|evm.model.CM009493.1.336 Q80VL1 TDRKH_MOUSE 91.071 0.994652 1.00179 Tdrkh - Tudor and KH domain-containing protein - Mus musculus (Mouse) - Tdrkh gene Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. Indicus|evm.model.CM009493.1.337 Q9UMX2 OAZ3_HUMAN 87.195 0.964497 0.719149 OAZ3 - Ornithine decarboxylase antizyme 3 - Homo sapiens (Human) - OAZ3 gene Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity). Indicus|evm.model.CM009493.1.338 Q2TBK2 RM09_BOVIN 100.000 0.992565 1.00373 MRPL9 - 39S ribosomal protein L9, mitochondrial precursor - Bos taurus (Bovine) - MRPL9 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion Indicus|evm.model.CM009493.1.339 Q32PB2 RIAD1_BOVIN 100.000 0.978495 1.01087 RIIAD1 - RIIa domain-containing protein 1 - Bos taurus (Bovine) - RIIAD1 gene Indicus|evm.model.CM009493.1.340 Q08E07 CELF3_BOVIN 96.320 0.995526 0.969631 CELF3 - CUGBP Elav-like family member 3 - Bos taurus (Bovine) - CELF3 gene RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Indicus|evm.model.CM009493.1.341 A5PKA5 SNX27_BOVIN 100.000 0.99631 1.00185 SNX27 - Sorting nexin-27 - Bos taurus (Bovine) - SNX27 gene Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes (By similarity). Indicus|evm.model.CM009493.1.342 P27628 TUFT1_BOVIN 98.974 0.994885 1.00256 TUFT1 - Tuftelin - Bos taurus (Bovine) - TUFT1 gene Involved in the mineralization and structural organization of enamel. Indicus|evm.model.CM009493.1.343 A9X1A5 CING_PAPAN 87.636 0.993305 0.998329 CGN - Cingulin - Papio anubis (Olive baboon) - CGN gene Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Indicus|evm.model.CM009493.1.344 Q7Z3K3 POGZ_HUMAN 95.966 0.997175 1.00426 POGZ - Pogo transposable element with ZNF domain - Homo sapiens (Human) - POGZ gene Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. Indicus|evm.model.CM009493.1.345 Q3T108 PSB4_BOVIN 99.621 0.992453 1.00379 PSMB4 - Proteasome subunit beta type-4 precursor - Bos taurus (Bovine) - PSMB4 gene Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Indicus|evm.model.CM009493.1.346 Q2KJ32 SBP1_BOVIN 99.576 0.995772 1.00212 SELENBP1 - Methanethiol oxidase - Bos taurus (Bovine) - SELENBP1 gene Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (By similarity). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport. Indicus|evm.model.CM009493.1.347 P48382 RFX5_HUMAN 87.500 0.823056 1.21104 RFX5 - DNA-binding protein RFX5 - Homo sapiens (Human) - RFX5 gene Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. Indicus|evm.model.CM009493.1.348 O02810 PI4KB_BOVIN 98.039 0.98401 0.996324 PI4KB - Phosphatidylinositol 4-kinase beta - Bos taurus (Bovine) - PI4KB gene Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP) (PubMed:9218477, PubMed:11526106). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). Indicus|evm.model.CM009493.1.349 Q8N1G0 ZN687_HUMAN 90.557 0.981717 1.01698 ZNF687 - Zinc finger protein 687 - Homo sapiens (Human) - ZNF687 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009493.1.350 Q2MHN1 FRIL_FELCA 78.049 0.931034 0.497143 FTL - Ferritin light chain - Felis catus (Cat) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009493.1.351 Q58DA0 PSMD4_BOVIN 100.000 0.994778 1.00262 PSMD4 - 26S proteasome non-ATPase regulatory subunit 4 - Bos taurus (Bovine) - PSMD4 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. Indicus|evm.model.CM009493.1.352 A2A3N6 PIPSL_HUMAN 90.161 0.882771 0.653132 PIPSL - Putative PIP5K1A and PSMD4-like protein - Homo sapiens (Human) - PIPSL gene Has negligible PIP5 kinase activity. Binds to ubiquitinated proteins. Indicus|evm.model.CM009493.1.353 P61078 UB2D3_RAT 89.116 0.80663 1.23129 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009493.1.354 Q5E9F6 VPS72_BOVIN 99.451 0.994521 1.00275 VPS72 - Vacuolar protein sorting-associated protein 72 homolog - Bos taurus (Bovine) - VPS72 gene Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Indicus|evm.model.CM009493.1.355 Q0VC48 TMOD4_BOVIN 100.000 0.99422 1.0029 TMOD4 - Tropomodulin-4 - Bos taurus (Bovine) - TMOD4 gene Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Indicus|evm.model.CM009493.1.356 Q3ZBR0 SCNM1_BOVIN 100.000 0.991342 1.00435 SCNM1 - Sodium channel modifier 1 - Bos taurus (Bovine) - SCNM1 gene Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites. Indicus|evm.model.CM009493.1.357 A0JNI1 LYSM1_BOVIN 99.556 0.99115 1.00444 LYSMD1 - LysM and putative peptidoglycan-binding domain-containing protein 1 - Bos taurus (Bovine) - LYSMD1 gene Indicus|evm.model.CM009493.1.358 Q3ZBK5 TP8L2_BOVIN 100.000 0.989189 1.00543 TNFAIP8L2 - Tumor necrosis factor alpha-induced protein 8-like protein 2 - Bos taurus (Bovine) - TNFAIP8L2 gene Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity). Indicus|evm.model.CM009493.1.359 Q9WTL3 SEM6C_RAT 90.254 0.90012 0.865625 Sema6c - Semaphorin-6C precursor - Rattus norvegicus (Rat) - Sema6c gene Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Indicus|evm.model.CM009493.1.360 Q0V8G2 GABP2_BOVIN 100.000 0.995536 1.00224 GABPB2 - GA-binding protein subunit beta-2 - Bos taurus (Bovine) - GABPB2 gene May function as transcription factor capable of interacting with purine rich repeats (GA repeats). Indicus|evm.model.CM009493.1.361 Q0VCT1 AF1Q_BOVIN 86.957 0.383966 2.63333 MLLT11 - Protein AF1q - Bos taurus (Bovine) - MLLT11 gene Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T-cell fate. Indicus|evm.model.CM009493.1.362 Q8BHL7 C42S1_MOUSE 98.214 0.325444 2.1125 Cdc42se1 - CDC42 small effector protein 1 - Mus musculus (Mouse) - Cdc42se1 gene Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity). Indicus|evm.model.CM009493.1.363 Q9BUN1 MENT_HUMAN 62.360 0.99435 1.03812 MENT - Protein MENT precursor - Homo sapiens (Human) - MENT gene Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B. Indicus|evm.model.CM009493.1.364 Q7Z465 BNIPL_HUMAN 87.430 0.994398 1 BNIPL - Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein - Homo sapiens (Human) - BNIPL gene May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Indicus|evm.model.CM009493.1.365 Q5E9Y6 PRUN1_BOVIN 100.000 0.995595 1.00221 PRUNE1 - Exopolyphosphatase PRUNE1 - Bos taurus (Bovine) - PRUNE1 gene Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1 (By similarity). Indicus|evm.model.CM009493.1.366 Q2KJ22 MINY1_BOVIN 99.787 0.995745 1.00213 MINDY1 - Ubiquitin carboxyl-terminal hydrolase MINDY-1 - Bos taurus (Bovine) - MINDY1 gene Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. Indicus|evm.model.CM009493.1.367 Q3ZC08 ANXA9_BOVIN 99.420 0.82494 1.2087 ANXA9 - Annexin A9 - Bos taurus (Bovine) - ANXA9 gene May act as a low affinity receptor for acetylcholine. Indicus|evm.model.CM009493.1.368 Q3ZBF8 CERS2_BOVIN 100.000 0.961929 1.03684 CERS2 - Ceramide synthase 2 - Bos taurus (Bovine) - CERS2 gene Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) chain as acyl donor (By similarity). May regulate lipid metabolism in hepatocytes (By similarity). Indicus|evm.model.CM009493.1.369 Q15047 SETB1_HUMAN 96.365 0.998451 1 SETDB1 - Histone-lysine N-methyltransferase SETDB1 - Homo sapiens (Human) - SETDB1 gene Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:27732843, PubMed:14536086). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086,). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Indicus|evm.model.CM009493.1.370 Q9BE97 ARNT_BOVIN 99.494 0.997472 1.00127 ARNT - Aryl hydrocarbon receptor nuclear translocator - Bos taurus (Bovine) - ARNT gene Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity). Indicus|evm.model.CM009493.1.371 Q5E968 CATK_BOVIN 99.696 0.979104 1.01824 CTSK - Cathepsin K precursor - Bos taurus (Bovine) - CTSK gene Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Indicus|evm.model.CM009493.1.372 Q712U6 ARP19_PIG 78.571 0.981982 0.991071 ARPP19 - cAMP-regulated phosphoprotein 19 - Sus scrofa (Pig) - ARPP19 gene Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity). Indicus|evm.model.CM009493.1.373 P25326 CATS_BOVIN 99.094 0.993976 1.00302 CTSS - Cathepsin S precursor - Bos taurus (Bovine) - CTSS gene Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. Indicus|evm.model.CM009493.1.374 Q2KIY6 HORM1_BOVIN 99.746 0.994924 1.00254 HORMAD1 - HORMA domain-containing protein 1 - Bos taurus (Bovine) - HORMAD1 gene Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Indicus|evm.model.CM009493.1.375 A6H7F6 GLP3L_BOVIN 100.000 0.993007 1.00351 GOLPH3L - Golgi phosphoprotein 3-like - Bos taurus (Bovine) - GOLPH3L gene Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. Indicus|evm.model.CM009493.1.376 O43768 ENSA_HUMAN 99.145 0.983051 0.975207 ENSA - Alpha-endosulfine - Homo sapiens (Human) - ENSA gene Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. Indicus|evm.model.CM009493.1.377 Q7YRZ9 MCL1_FELCA 90.313 0.994302 1.00286 MCL1 - Induced myeloid leukemia cell differentiation protein Mcl-1 homolog - Felis catus (Cat) - MCL1 gene Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). Indicus|evm.model.CM009493.1.378 Q6UY14 ATL4_HUMAN 86.140 0.998133 0.997207 ADAMTSL4 - ADAMTS-like protein 4 precursor - Homo sapiens (Human) - ADAMTSL4 gene Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. Indicus|evm.model.CM009493.1.379 Q16610 ECM1_HUMAN 71.429 0.868182 1.22222 ECM1 - Extracellular matrix protein 1 precursor - Homo sapiens (Human) - ECM1 gene Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. Indicus|evm.model.CM009493.1.380 Q9BW92 SYTM_HUMAN 88.022 0.997218 1.00139 TARS2 - Threonine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - TARS2 gene Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain. Indicus|evm.model.CM009493.1.381 Q5VT52 RPRD2_HUMAN 94.634 0.960429 1.02053 RPRD2 - Regulation of nuclear pre-mRNA domain-containing protein 2 - Homo sapiens (Human) - RPRD2 gene nucleoplasm, RNA polymerase II, holoenzyme, RNA polymerase II complex binding, mRNA 3'-end processing, snRNA transcription by RNA polymerase II Indicus|evm.model.CM009493.1.382 O43395 PRPF3_HUMAN 100.000 0.898551 1.11127 PRPF3 - U4/U6 small nuclear ribonucleoprotein Prp3 - Homo sapiens (Human) - PRPF3 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). Indicus|evm.model.CM009493.1.383 Q8N365 CIART_HUMAN 80.729 0.992228 1.0026 CIART - Circadian-associated transcriptional repressor - Homo sapiens (Human) - CIART gene Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). Indicus|evm.model.CM009493.1.384 Q148C7 CA054_BOVIN 100.000 0.984848 1.00763 Uncharacterized protein C1orf54 homolog precursor - Bos taurus (Bovine) Indicus|evm.model.CM009493.1.385 Q8BVF7 APH1A_MOUSE 98.868 0.992481 1.00377 Aph1a - Gamma-secretase subunit APH-1A - Mus musculus (Mouse) - Aph1a gene Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15634781, PubMed:19369254). Required for normal gamma-secretase assembly (PubMed:15634781, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). Indicus|evm.model.CM009493.1.386 Q9ULX7 CAH14_HUMAN 87.126 0.988131 1 CA14 - Carbonic anhydrase 14 precursor - Homo sapiens (Human) - CA14 gene Reversible hydration of carbon dioxide. Indicus|evm.model.CM009493.1.387 Q9BTT0 AN32E_HUMAN 95.539 0.992453 0.988806 ANP32E - Acidic leucine-rich nuclear phosphoprotein 32 family member E - Homo sapiens (Human) - ANP32E gene Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. Indicus|evm.model.CM009493.1.388 A4IFK0 PKHO1_BOVIN 99.511 0.995122 1.00244 PLEKHO1 - Pleckstrin homology domain-containing family O member 1 - Bos taurus (Bovine) - PLEKHO1 gene Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity). Indicus|evm.model.CM009493.1.389 Q9NRW7 VPS45_HUMAN 98.596 0.996497 1.00175 VPS45 - Vacuolar protein sorting-associated protein 45 - Homo sapiens (Human) - VPS45 gene May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. Indicus|evm.model.CM009493.1.390 Q6GQQ9 OTU7B_HUMAN 93.713 0.803435 1.24318 OTUD7B - OTU domain-containing protein 7B - Homo sapiens (Human) - OTUD7B gene Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. Indicus|evm.model.CM009493.1.391 A4FU01 MTMRB_HUMAN 90.387 0.992847 0.985896 MTMR11 - Myotubularin-related protein 11 - Homo sapiens (Human) - MTMR11 gene cytoplasm, extracellular exosome, phosphatidylinositol-3-phosphatase activity, phosphatidylinositol dephosphorylation Indicus|evm.model.CM009493.1.392 Q15427 SF3B4_HUMAN 99.764 0.995294 1.00236 SF3B4 - Splicing factor 3B subunit 4 - Homo sapiens (Human) - SF3B4 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). Indicus|evm.model.CM009493.1.393 Q29397 SV2A_BOVIN 100.000 0.997308 1.00135 SV2A - Synaptic vesicle glycoprotein 2A - Bos taurus (Bovine) - SV2A gene Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). Indicus|evm.model.CM009493.1.394 Q3T138 BOLA1_BOVIN 100.000 0.985294 1.00741 BOLA1 - BolA-like protein 1 - Bos taurus (Bovine) - BOLA1 gene Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5. May protect cells against oxidative stress (By similarity). Indicus|evm.model.CM009493.1.395 Q8IUE6 H2A2B_HUMAN 100.000 0.984733 1.00769 H2AC21 - Histone H2A type 2-B - Homo sapiens (Human) - H2AC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009493.1.396 Q64523 H2A2C_MOUSE 100.000 0.670807 1.24806 H2ac20 - Histone H2A type 2-C - Mus musculus (Mouse) - H2ac20 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009493.1.397 Q16778 H2B2E_HUMAN 100.000 0.984252 1.00794 H2BC21 - Histone H2B type 2-E - Homo sapiens (Human) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009493.1.398 P84232 H32_PORAF 100.000 0.985401 1.00735 Histone H3.2 - Poroderma africanum (Striped catshark) Indicus|evm.model.CM009493.1.399 P0CC09 H2A2A_RAT 100.000 0.984733 1.00769 H2ac18 - Histone H2A type 2-A - Rattus norvegicus (Rat) - H2ac18 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Indicus|evm.model.CM009493.1.400 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009493.1.401 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009493.1.402 P0CC09 H2A2A_RAT 100.000 0.984733 1.00769 H2ac18 - Histone H2A type 2-A - Rattus norvegicus (Rat) - H2ac18 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Indicus|evm.model.CM009493.1.403 P84232 H32_PORAF 100.000 0.985401 1.00735 Histone H3.2 - Poroderma africanum (Striped catshark) Indicus|evm.model.CM009493.1.404 Q6WV90 H4_MYTGA 100.000 0.675497 1.46602 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009493.1.405 P84232 H32_PORAF 100.000 0.985401 1.00735 Histone H3.2 - Poroderma africanum (Striped catshark) Indicus|evm.model.CM009493.1.406 Q5QNW6 H2B2F_HUMAN 100.000 0.984252 1.00794 H2BC18 - Histone H2B type 2-F - Homo sapiens (Human) - H2BC18 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009493.1.407 P12314 FCGR1_HUMAN 67.941 0.968571 0.935829 FCGR1A - High affinity immunoglobulin gamma Fc receptor I precursor - Homo sapiens (Human) - FCGR1A gene High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Indicus|evm.model.CM009493.1.409 Q32LC2 NBP6L_BOVIN 98.661 0.933054 1.06696 Neuroblastoma breakpoint family member 6-like protein - Bos taurus (Bovine) Indicus|evm.model.CM009493.1.411 P62752 RL23A_RAT 98.246 0.974138 0.74359 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009493.1.413 Q32LC2 NBP6L_BOVIN 82.609 0.156794 1.28125 Neuroblastoma breakpoint family member 6-like protein - Bos taurus (Bovine) Indicus|evm.model.CM009493.1.415 Q6ZVN8 RGMC_HUMAN 90.465 0.995327 1.00469 HJV - Hemojuvelin precursor - Homo sapiens (Human) - HJV gene Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966). Indicus|evm.model.CM009493.1.416 Q2HY40 TXNIP_PIG 95.396 0.994898 1.00256 TXNIP - Thioredoxin-interacting protein - Sus scrofa (Pig) - TXNIP gene May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth (By similarity). Indicus|evm.model.CM009493.1.417 Q1RMR0 RPC7L_BOVIN 100.000 0.745704 1.33486 POLR3GL - DNA-directed RNA polymerase III subunit RPC7-like - Bos taurus (Bovine) - POLR3GL gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Indicus|evm.model.CM009493.1.418 Q5BJT1 AN34A_RAT 96.573 0.99596 1 Ankrd34a - Ankyrin repeat domain-containing protein 34A - Rattus norvegicus (Rat) - Ankrd34a gene Indicus|evm.model.CM009493.1.419 Q27W01 RBM8A_RAT 100.000 0.344622 2.88506 Rbm8a - RNA-binding protein 8A - Rattus norvegicus (Rat) - Rbm8a gene Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity). Indicus|evm.model.CM009493.1.420 Q95MG6 GNRR2_CALJA 87.121 0.642157 0.536842 GNRHR2 - Gonadotropin-releasing hormone II receptor - Callithrix jacchus (White-tufted-ear marmoset) - GNRHR2 gene Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009493.1.421 Q148K5 PX11B_BOVIN 100.000 0.992278 1.00388 PEX11B - Peroxisomal membrane protein 11B - Bos taurus (Bovine) - PEX11B gene Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface. Indicus|evm.model.CM009493.1.422 O75578 ITA10_HUMAN 89.492 0.98472 1.00943 ITGA10 - Integrin alpha-10 precursor - Homo sapiens (Human) - ITGA10 gene Integrin alpha-10/beta-1 is a receptor for collagen. Indicus|evm.model.CM009493.1.423 Q8N283 ANR35_HUMAN 84.263 0.99801 1.004 ANKRD35 - Ankyrin repeat domain-containing protein 35 - Homo sapiens (Human) - ANKRD35 gene Indicus|evm.model.CM009493.1.424 Q9Y6X2 PIAS3_HUMAN 99.063 0.993007 0.683121 PIAS3 - E3 SUMO-protein ligase PIAS3 - Homo sapiens (Human) - PIAS3 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). Indicus|evm.model.CM009493.1.425 A4FUG7 NUD17_BOVIN 99.669 0.993399 1.00331 NUDT17 - Nucleoside diphosphate-linked moiety X motif 17 - Bos taurus (Bovine) - NUDT17 gene Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. Indicus|evm.model.CM009493.1.426 Q2TBL4 RPC3_BOVIN 99.812 0.996255 1.00188 POLR3C - DNA-directed RNA polymerase III subunit RPC3 - Bos taurus (Bovine) - POLR3C gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF-Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner. Indicus|evm.model.CM009493.1.427 Q9D0C1 RN115_MOUSE 85.069 0.935374 0.963934 Rnf115 - E3 ubiquitin-protein ligase RNF115 - Mus musculus (Mouse) - Rnf115 gene E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4. Indicus|evm.model.CM009493.1.428 Q3T0X8 NHRF3_BOVIN 99.615 0.996161 1.00192 PDZK1 - Na(+)/H(+) exchange regulatory cofactor NHE-RF3 - Bos taurus (Bovine) - PDZK1 gene A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). Indicus|evm.model.CM009493.1.429 Q5BIM9 GPHR_BOVIN 100.000 0.573386 1.12308 GPR89 - Golgi pH regulator - Bos taurus (Bovine) - GPR89 gene Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (By similarity). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity). Indicus|evm.model.CM009493.1.430 P55917 CXA8_SHEEP 98.182 0.995465 1.00227 GJA8 - Gap junction alpha-8 protein - Ovis aries (Sheep) - GJA8 gene Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore. Indicus|evm.model.CM009493.1.431 Q0VCR2 CXA5_BOVIN 99.443 0.994444 1.00279 GJA5 - Gap junction alpha-5 protein - Bos taurus (Bovine) - GJA5 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009493.1.433 A6H757 PPA6_BOVIN 99.534 0.995349 1.00233 ACP6 - Lysophosphatidic acid phosphatase type 6 precursor - Bos taurus (Bovine) - ACP6 gene Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. Indicus|evm.model.CM009493.1.434 Q95KQ6 BCL9_PIG 100.000 0.0903994 10.9769 BCL9 - B-cell CLL/lymphoma 9 protein - Sus scrofa (Pig) - BCL9 gene Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). Indicus|evm.model.CM009493.1.435 Q3B7N1 CHD1L_BOVIN 99.443 0.997773 1.00111 CHD1L - Chromodomain-helicase-DNA-binding protein 1-like - Bos taurus (Bovine) - CHD1L gene DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. Indicus|evm.model.CM009493.1.436 P49326 FMO5_HUMAN 84.991 0.996255 1.00188 FMO5 - Flavin-containing monooxygenase 5 - Homo sapiens (Human) - FMO5 gene Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:28783300, PubMed:26771671, PubMed:20947616). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive (PubMed:26771671, PubMed:7872795). In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline (PubMed:28783300). Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (PubMed:26771671). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). Indicus|evm.model.CM009493.1.437 O43741 AAKB2_HUMAN 98.897 0.992674 1.00368 PRKAB2 - 5'-AMP-activated protein kinase subunit beta-2 - Homo sapiens (Human) - PRKAB2 gene Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). Indicus|evm.model.CM009493.1.441 Q5VU43 MYOME_HUMAN 85.484 0.924617 1.08568 PDE4DIP - Myomegalin - Homo sapiens (Human) - PDE4DIP gene Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Indicus|evm.model.CM009493.1.442 Q4KM74 SC22B_RAT 99.535 0.990741 1.00465 Sec22b - Vesicle-trafficking protein SEC22b - Rattus norvegicus (Rat) - Sec22b gene SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. Indicus|evm.model.CM009493.1.443 Q04721 NOTC2_HUMAN 94.941 0.999191 1.0004 NOTCH2 - Neurogenic locus notch homolog protein 2 precursor - Homo sapiens (Human) - NOTCH2 gene Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). Indicus|evm.model.CM009493.1.444 Q9UKF2 ADA30_HUMAN 66.339 0.993007 0.905063 ADAM30 - Disintegrin and metalloproteinase domain-containing protein 30 precursor - Homo sapiens (Human) - ADAM30 gene Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034). Indicus|evm.model.CM009493.1.445 Q9UKF2 ADA30_HUMAN 66.993 0.993026 0.907595 ADAM30 - Disintegrin and metalloproteinase domain-containing protein 30 precursor - Homo sapiens (Human) - ADAM30 gene Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034). Indicus|evm.model.CM009493.1.446 Q9UKF2 ADA30_HUMAN 62.791 0.844622 0.317722 ADAM30 - Disintegrin and metalloproteinase domain-containing protein 30 precursor - Homo sapiens (Human) - ADAM30 gene Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034). Indicus|evm.model.CM009493.1.447 Q9D8G5 REG4_MOUSE 58.571 0.706215 1.12739 Reg4 - Regenerating islet-derived protein 4 precursor - Mus musculus (Mouse) - Reg4 gene Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity). Indicus|evm.model.CM009493.1.448 Q2KIE6 HMCS2_BOVIN 100.000 0.996071 1.00197 HMGCS2 - Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor - Bos taurus (Bovine) - HMGCS2 gene Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. Indicus|evm.model.CM009493.1.449 Q5EAD2 SERA_BOVIN 100.000 0.996255 1.00188 PHGDH - D-3-phosphoglycerate dehydrogenase - Bos taurus (Bovine) - PHGDH gene Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. Indicus|evm.model.CM009493.1.450 Q5TEC3 ZN697_HUMAN 80.254 0.99637 1.01101 ZNF697 - Zinc finger protein 697 - Homo sapiens (Human) - ZNF697 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009493.1.451 P14893 3BHS_BOVIN 100.000 0.49534 2.0134 HSD3B - 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase - Bos taurus (Bovine) - HSD3B gene 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Indicus|evm.model.CM009493.1.452 Q3T099 SYWM_BOVIN 100.000 0.99446 1.00278 WARS2 - Tryptophan--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - WARS2 gene Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis. Indicus|evm.model.CM009493.1.454 Q96SF7 TBX15_HUMAN 93.355 0.99651 0.951827 TBX15 - T-box transcription factor TBX15 - Homo sapiens (Human) - TBX15 gene Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity). Indicus|evm.model.CM009493.1.455 Q9NTZ6 RBM12_HUMAN 79.603 0.449664 0.799356 RBM12 - RNA-binding protein 12 - Homo sapiens (Human) - RBM12 gene nucleoplasm, ribonucleoprotein complex, RNA binding, regulation of RNA splicing Indicus|evm.model.CM009493.1.457 Q6Q759 SPG17_HUMAN 77.605 0.999348 0.689609 SPAG17 - Sperm-associated antigen 17 - Homo sapiens (Human) - SPAG17 gene Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. Indicus|evm.model.CM009493.1.458 Q9UNX4 WDR3_HUMAN 94.274 0.997881 1.00106 WDR3 - WD repeat-containing protein 3 - Homo sapiens (Human) - WDR3 gene nuclear membrane, nucleolus, nucleoplasm, Pwp2p-containing subcomplex of 90S preribosome, small-subunit processome, RNA binding, snoRNA binding, maturation of SSU-rRNA, rRNA processing Indicus|evm.model.CM009493.1.459 Q2KIX2 GDAP2_BOVIN 99.799 0.995984 1.00201 GDAP2 - Ganglioside-induced differentiation-associated protein 2 - Bos taurus (Bovine) - GDAP2 gene Indicus|evm.model.CM009493.1.460 Q4R8X4 TET5C_MACFA 94.751 0.925641 0.997442 TENT5C - Terminal nucleotidyltransferase 5C - Macaca fascicularis (Crab-eating macaque) - TENT5C gene Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death. Indicus|evm.model.CM009493.1.461 Q3T0M7 RANG_BOVIN 97.826 0.957895 0.461165 RANBP1 - Ran-specific GTPase-activating protein - Bos taurus (Bovine) - RANBP1 gene Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity). Indicus|evm.model.CM009493.1.462 O60476 MA1A2_HUMAN 95.632 0.996885 1.00156 MAN1A2 - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB - Homo sapiens (Human) - MAN1A2 gene Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Indicus|evm.model.CM009493.1.463 Q7Z7D3 VTCN1_HUMAN 91.339 0.798107 1.12411 VTCN1 - V-set domain-containing T-cell activation inhibitor 1 precursor - Homo sapiens (Human) - VTCN1 gene Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Indicus|evm.model.CM009493.1.464 Q5BIM1 TRI45_BOVIN 100.000 0.996558 1.00172 TRIM45 - Tripartite motif-containing protein 45 - Bos taurus (Bovine) - TRIM45 gene May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. Indicus|evm.model.CM009493.1.465 Q9UNY4 TTF2_HUMAN 76.949 0.976471 1.0241 TTF2 - Transcription termination factor 2 - Homo sapiens (Human) - TTF2 gene DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. Indicus|evm.model.CM009493.1.466 Q93033 IGSF2_HUMAN 76.181 0.981244 0.992165 CD101 - Immunoglobulin superfamily member 2 precursor - Homo sapiens (Human) - CD101 gene Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. Indicus|evm.model.CM009493.1.467 Q9P2B2 FPRP_HUMAN 90.476 0.991926 0.986348 PTGFRN - Prostaglandin F2 receptor negative regulator precursor - Homo sapiens (Human) - PTGFRN gene Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity). Indicus|evm.model.CM009493.1.468 P06729 CD2_HUMAN 53.179 0.9941 0.965812 CD2 - T-cell surface antigen CD2 precursor - Homo sapiens (Human) - CD2 gene CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. Indicus|evm.model.CM009493.1.469 O75054 IGSF3_HUMAN 89.367 0.997473 0.994137 IGSF3 - Immunoglobulin superfamily member 3 precursor - Homo sapiens (Human) - IGSF3 gene cell surface, integral component of membrane, lacrimal gland development Indicus|evm.model.CM009493.1.470 P19256 LFA3_HUMAN 47.541 0.971545 0.984 CD58 - Lymphocyte function-associated antigen 3 precursor - Homo sapiens (Human) - CD58 gene Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Indicus|evm.model.CM009493.1.471 Q08DA1 AT1A1_BOVIN 100.000 0.979749 1.01567 ATP1A1 - Sodium/potassium-transporting ATPase subunit alpha-1 precursor - Bos taurus (Bovine) - ATP1A1 gene This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Indicus|evm.model.CM009493.1.472 Q8N8X9 MB213_HUMAN 78.090 0.988858 0.991713 MAB21L3 - Protein mab-21-like 3 - Homo sapiens (Human) - MAB21L3 gene Indicus|evm.model.CM009493.1.473 Q8IZD6 S22AF_HUMAN 94.333 0.99635 1.00183 SLC22A15 - Solute carrier family 22 member 15 - Homo sapiens (Human) - SLC22A15 gene Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. Indicus|evm.model.CM009493.1.474 Q02575 HEN1_HUMAN 98.387 0.455224 1.00752 NHLH1 - Helix-loop-helix protein 1 - Homo sapiens (Human) - NHLH1 gene May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. Indicus|evm.model.CM009493.1.475 P12637 CASQ2_CANLF 96.505 0.858796 1.05366 CASQ2 - Calsequestrin-2 precursor - Canis lupus familiaris (Dog) - CASQ2 gene Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:3427023). Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. Indicus|evm.model.CM009493.1.476 Q8TAA9 VANG1_HUMAN 96.183 0.99619 1.00191 VANGL1 - Vang-like protein 1 - Homo sapiens (Human) - VANGL1 gene plasma membrane, Wnt signaling pathway, planar cell polarity pathway Indicus|evm.model.CM009493.1.477 P06576 ATPB_HUMAN 77.778 0.927083 0.181474 ATP5F1B - ATP synthase subunit beta, mitochondrial precursor - Homo sapiens (Human) - ATP5F1B gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Indicus|evm.model.CM009493.1.478 Q2HJ94 DNJA2_BOVIN 91.429 0.237113 0.706311 DNAJA2 - DnaJ homolog subfamily A member 2 precursor - Bos taurus (Bovine) - DNAJA2 gene Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Indicus|evm.model.CM009493.1.479 P13600 NGF_BOVIN 99.585 0.836237 1.19087 NGF - Beta-nerve growth factor precursor - Bos taurus (Bovine) - NGF gene Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity). Indicus|evm.model.CM009493.1.480 O60636 TSN2_HUMAN 83.258 0.989848 0.891403 TSPAN2 - Tetraspanin-2 - Homo sapiens (Human) - TSPAN2 gene May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. Indicus|evm.model.CM009493.1.481 Q15431 SYCP1_HUMAN 71.828 0.997735 0.904713 SYCP1 - Synaptonemal complex protein 1 - Homo sapiens (Human) - SYCP1 gene Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Indicus|evm.model.CM009493.1.482 Q28852 ATP5L_BOVIN 96.117 0.980769 1.00971 ATP5MG - ATP synthase subunit g, mitochondrial - Bos taurus (Bovine) - ATP5MG gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Indicus|evm.model.CM009493.1.483 Q0VCF3 SIKE1_BOVIN 100.000 0.990385 1.00483 SIKE1 - Suppressor of IKBKE 1 - Bos taurus (Bovine) - SIKE1 gene Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). Indicus|evm.model.CM009493.1.484 P29174 CSDE1_CAVPO 100.000 0.133728 7.41228 CSDE1 - Cold shock domain-containing protein E1 - Cavia porcellus (Guinea pig) - CSDE1 gene RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules. Indicus|evm.model.CM009493.1.485 Q2MJK3 RASN_PIG 100.000 0.989474 1.00529 NRAS - GTPase NRas precursor - Sus scrofa (Pig) - NRAS gene Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Indicus|evm.model.CM009493.1.486 P23109 AMPD1_HUMAN 84.483 0.804196 0.183333 AMPD1 - AMP deaminase 1 - Homo sapiens (Human) - AMPD1 gene AMP deaminase plays a critical role in energy metabolism. Indicus|evm.model.CM009493.1.487 P23109 AMPD1_HUMAN 95.432 0.996743 0.787179 AMPD1 - AMP deaminase 1 - Homo sapiens (Human) - AMPD1 gene AMP deaminase plays a critical role in energy metabolism. Indicus|evm.model.CM009493.1.488 Q68D51 DEN2C_HUMAN 91.183 0.991453 1.00862 DENND2C - DENN domain-containing protein 2C - Homo sapiens (Human) - DENND2C gene Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Indicus|evm.model.CM009493.1.489 Q9D287 SPF27_MOUSE 98.222 0.99115 1.00444 Bcas2 - Pre-mRNA-splicing factor SPF27 - Mus musculus (Mouse) - Bcas2 gene Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). Indicus|evm.model.CM009493.1.490 Q9UPN9 TRI33_HUMAN 97.516 0.998225 1 TRIM33 - E3 ubiquitin-protein ligase TRIM33 - Homo sapiens (Human) - TRIM33 gene Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). Indicus|evm.model.CM009493.1.491 Q5T7P8 SYT6_HUMAN 96.832 0.877836 1.12353 SYT6 - Synaptotagmin-6 - Homo sapiens (Human) - SYT6 gene May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). Indicus|evm.model.CM009493.1.492 Q0VCP3 OLFL3_BOVIN 99.507 0.995086 1.00246 OLFML3 - Olfactomedin-like protein 3 precursor - Bos taurus (Bovine) - OLFML3 gene Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes (By similarity). Indicus|evm.model.CM009493.1.493 Q86Z02 HIPK1_HUMAN 98.595 0.979741 1.01983 HIPK1 - Homeodomain-interacting protein kinase 1 - Homo sapiens (Human) - HIPK1 gene Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). Indicus|evm.model.CM009493.1.494 D2H8V8 DCR1B_AILME 85.227 0.970534 1.02647 DCLRE1B - 5' exonuclease Apollo - Ailuropoda melanoleuca (Giant panda) - DCLRE1B gene 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint (By similarity). Indicus|evm.model.CM009493.1.495 Q9Y6B7 AP4B1_HUMAN 92.963 0.997297 1.00135 AP4B1 - AP-4 complex subunit beta-1 - Homo sapiens (Human) - AP4B1 gene Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). Indicus|evm.model.CM009493.1.496 Q0II48 B2L15_BOVIN 100.000 0.98773 1.00617 BCL2L15 - Bcl-2-like protein 15 - Bos taurus (Bovine) - BCL2L15 gene cytosol, nucleus Indicus|evm.model.CM009493.1.497 Q9Y2R2 PTN22_HUMAN 72.464 0.96 0.929368 PTPN22 - Tyrosine-protein phosphatase non-receptor type 22 - Homo sapiens (Human) - PTPN22 gene Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). Indicus|evm.model.CM009493.1.498 Q5VWQ0 RSBN1_HUMAN 95.392 0.997512 1.00249 RSBN1 - Lysine-specific demethylase 9 - Homo sapiens (Human) - RSBN1 gene Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. Indicus|evm.model.CM009493.1.499 Q08DA4 PHTF1_BOVIN 99.869 0.997379 1.00131 PHTF1 - Protein PHTF1 - Bos taurus (Bovine) - PHTF1 gene Indicus|evm.model.CM009493.1.500 Q5TCQ9 MAGI3_HUMAN 89.474 0.997967 0.996624 MAGI3 - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 - Homo sapiens (Human) - MAGI3 gene Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. Indicus|evm.model.CM009493.1.501 P30050 RL12_HUMAN 91.515 0.987578 0.975758 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Indicus|evm.model.CM009493.1.502 O94898 LRIG2_HUMAN 91.737 0.998124 1.00094 LRIG2 - Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor - Homo sapiens (Human) - LRIG2 gene extracellular matrix, extracellular space Indicus|evm.model.CM009493.1.503 Q3MHW6 MOT1_BOVIN 100.000 0.996016 1.002 SLC16A1 - Monocarboxylate transporter 1 - Bos taurus (Bovine) - SLC16A1 gene Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Indicus|evm.model.CM009493.1.504 Q3MHW6 MOT1_BOVIN 76.305 0.993902 0.982036 SLC16A1 - Monocarboxylate transporter 1 - Bos taurus (Bovine) - SLC16A1 gene Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Indicus|evm.model.CM009493.1.505 Q7TPG6 TAFA3_MOUSE 81.111 0.864078 0.780303 Tafa3 - Chemokine-like protein TAFA-3 precursor - Mus musculus (Mouse) - Tafa3 gene Plays a role in the regulation of microglia polarization. Indicus|evm.model.CM009493.1.506 Q5JR12 PPM1J_HUMAN 94.455 0.996047 1.00198 PPM1J - Protein phosphatase 1J - Homo sapiens (Human) - PPM1J gene protein serine/threonine phosphatase activity, protein dephosphorylation Indicus|evm.model.CM009493.1.507 Q5RCK9 RHOC_PONAB 100.000 0.989691 1.00518 RHOC - Rho-related GTP-binding protein RhoC precursor - Pongo abelii (Sumatran orangutan) - RHOC gene Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). Indicus|evm.model.CM009493.1.508 Q0V8H6 MOV10_BOVIN 100.000 0.998008 1.001 MOV10 - Putative helicase MOV-10 - Bos taurus (Bovine) - MOV10 gene 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7 (By similarity). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity). Indicus|evm.model.CM009493.1.509 A4FUA8 CAZA1_BOVIN 100.000 0.993031 1.0035 CAPZA1 - F-actin-capping protein subunit alpha-1 - Bos taurus (Bovine) - CAPZA1 gene F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. Indicus|evm.model.CM009493.1.510 A3KN28 ST7L_BOVIN 100.000 0.996403 1.0018 ST7L - Suppressor of tumorigenicity 7 protein-like - Bos taurus (Bovine) - ST7L gene Indicus|evm.model.CM009493.1.511 Q93097 WNT2B_HUMAN 97.208 0.994937 1.01023 WNT2B - Protein Wnt-2b precursor - Homo sapiens (Human) - WNT2B gene Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development. Indicus|evm.model.CM009493.1.512 Q5RDH2 CT2NL_PONAB 92.019 0.996875 1.00156 CTTNBP2NL - CTTNBP2 N-terminal-like protein - Pongo abelii (Sumatran orangutan) - CTTNBP2NL gene Regulates lamellipodial actin dynamics in a CTTN-dependent manner. Indicus|evm.model.CM009493.1.515 Q9UK17 KCND3_HUMAN 92.580 0.992453 0.40458 KCND3 - Potassium voltage-gated channel subfamily D member 3 - Homo sapiens (Human) - KCND3 gene Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Indicus|evm.model.CM009493.1.516 Q9UHI6 DDX20_HUMAN 88.015 0.997579 1.00243 DDX20 - Probable ATP-dependent RNA helicase DDX20 - Homo sapiens (Human) - DDX20 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). Indicus|evm.model.CM009493.1.517 A6QP24 INKA2_BOVIN 99.660 0.99322 1.0034 INKA2 - PAK4-inhibitor INKA2 - Bos taurus (Bovine) - INKA2 gene Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity. Indicus|evm.model.CM009493.1.518 P62836 RAP1A_RAT 100.000 0.989189 1.00543 Rap1a - Ras-related protein Rap-1A precursor - Rattus norvegicus (Rat) - Rap1a gene Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. Indicus|evm.model.CM009493.1.519 Q0VC81 AA3R_BOVIN 92.969 0.368116 1.08833 ADORA3 - Adenosine receptor A3 - Bos taurus (Bovine) - ADORA3 gene Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Indicus|evm.model.CM009493.1.520 Q3U7U4 CA162_MOUSE 58.261 0.801418 1.06818 Transmembrane protein C1orf162 homolog - Mus musculus (Mouse) Indicus|evm.model.CM009493.1.521 P13619 AT5F1_BOVIN 99.609 0.992218 1.00391 ATP5PB - ATP synthase F(0) complex subunit B1, mitochondrial precursor - Bos taurus (Bovine) - ATP5PB gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Indicus|evm.model.CM009493.1.522 Q5E9I7 MEP50_BOVIN 99.708 0.994169 1.00292 WDR77 - Methylosome protein 50 - Bos taurus (Bovine) - WDR77 gene Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Indicus|evm.model.CM009493.1.523 Q28042 OVGP1_BOVIN 99.255 0.990758 1.00745 OVGP1 - Oviduct-specific glycoprotein precursor - Bos taurus (Bovine) - OVGP1 gene Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. Indicus|evm.model.CM009493.1.524 Q689Z7 PEPB_MONDO 59.398 0.84507 0.726343 PGB - Pepsin B precursor - Monodelphis domestica (Gray short-tailed opossum) - PGB gene Hydrolyzes various peptides including beta-endorphin, insulin B chain, dynorphin A, and neurokinin A, with high specificity for the cleavage of the Phe-Xaa bonds. Indicus|evm.model.CM009493.1.526 Q91XA9 CHIA_MOUSE 47.679 0.9642 0.885835 Chia - Acidic mammalian chitinase precursor - Mus musculus (Mouse) - Chia gene Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme. Indicus|evm.model.CM009493.1.527 Q2TBS4 PIFO_BOVIN 77.957 0.755102 1.27604 PIFO - Protein pitchfork - Bos taurus (Bovine) - PIFO gene During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner (By similarity). Indicus|evm.model.CM009493.1.528 Q95M17 CHIA_BOVIN 100.000 0.995772 1.00212 CHIA - Acidic mammalian chitinase precursor - Bos taurus (Bovine) - CHIA gene Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding (By similarity). Indicus|evm.model.CM009493.1.529 Q91XA9 CHIA_MOUSE 50.435 0.972973 0.234672 Chia - Acidic mammalian chitinase precursor - Mus musculus (Mouse) - Chia gene Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme. Indicus|evm.model.CM009493.1.531 Q15782 CH3L2_HUMAN 88.205 0.761252 1.31026 CHI3L2 - Chitinase-3-like protein 2 precursor - Homo sapiens (Human) - CHI3L2 gene Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. Indicus|evm.model.CM009493.1.532 Q9H6A0 DEN2D_HUMAN 87.473 0.995736 0.995754 DENND2D - DENN domain-containing protein 2D - Homo sapiens (Human) - DENND2D gene Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Indicus|evm.model.CM009493.1.533 Q9Y6K0 CEPT1_HUMAN 95.673 0.995204 1.0024 CEPT1 - Choline/ethanolaminephosphotransferase 1 - Homo sapiens (Human) - CEPT1 gene Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. Indicus|evm.model.CM009493.1.534 Q3ZC48 DRAM2_BOVIN 100.000 0.992509 1.00376 DRAM2 - DNA damage-regulated autophagy modulator protein 2 - Bos taurus (Bovine) - DRAM2 gene Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1. Indicus|evm.model.CM009493.1.535 Q5T3J3 LRIF1_HUMAN 83.290 0.997403 1.0013 LRIF1 - Ligand-dependent nuclear receptor-interacting factor 1 - Homo sapiens (Human) - LRIF1 gene Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Indicus|evm.model.CM009493.1.536 Q58DM3 CD53_BOVIN 99.543 0.990909 1.00457 CD53 - Leukocyte surface antigen CD53 - Bos taurus (Bovine) - CD53 gene Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity). Indicus|evm.model.CM009493.1.537 P16390 KCNA3_MOUSE 96.402 0.99619 0.994318 Kcna3 - Potassium voltage-gated channel subfamily A member 3 - Mus musculus (Mouse) - Kcna3 gene Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Indicus|evm.model.CM009493.1.538 P16389 KCNA2_HUMAN 100.000 0.996 1.002 KCNA2 - Potassium voltage-gated channel subfamily A member 2 - Homo sapiens (Human) - KCNA2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559, PubMed:11211111, PubMed:23769686). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559, PubMed:20220134). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:23769686). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity). Indicus|evm.model.CM009493.1.540 Q16322 KCA10_HUMAN 94.129 0.996094 1.00196 KCNA10 - Potassium voltage-gated channel subfamily A member 10 - Homo sapiens (Human) - KCNA10 gene Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. Indicus|evm.model.CM009493.1.541 P00794 CHYM_BOVIN 99.738 0.994764 1.00262 CYM - Chymosin precursor - Bos taurus (Bovine) - CYM gene Chymosin is synthesized in the mucosa of the abomasum (fourth stomach) of young (unweaned) ruminants. The enzyme hydrolyzes casein to paracasein. Indicus|evm.model.CM009493.1.542 P58294 PROK1_HUMAN 87.619 0.981132 1.00952 PROK1 - Prokineticin-1 precursor - Homo sapiens (Human) - PROK1 gene Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. Indicus|evm.model.CM009493.1.543 O15374 MOT5_HUMAN 83.707 0.972056 1.02875 SLC16A4 - Monocarboxylate transporter 5 - Homo sapiens (Human) - SLC16A4 gene Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). Indicus|evm.model.CM009493.1.544 Q96T37 RBM15_HUMAN 97.382 0.990654 0.98567 RBM15 - RNA-binding protein 15 - Homo sapiens (Human) - RBM15 gene RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). Indicus|evm.model.CM009493.1.545 Q63734 KCNC4_RAT 97.694 0.952532 1.0112 Kcnc4 - Potassium voltage-gated channel subfamily C member 4 - Rattus norvegicus (Rat) - Kcnc4 gene This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Indicus|evm.model.CM009493.1.546 Q9H1V8 S6A17_HUMAN 85.282 0.996875 0.88033 SLC6A17 - Sodium-dependent neutral amino acid transporter SLC6A17 - Homo sapiens (Human) - SLC6A17 gene Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). Indicus|evm.model.CM009493.1.548 Q2T9Q2 UBL4B_BOVIN 99.394 0.987952 1.00606 UBL4B - Ubiquitin-like protein 4B - Bos taurus (Bovine) - UBL4B gene Indicus|evm.model.CM009493.1.549 O95076 ALX3_HUMAN 92.038 0.963077 0.947522 ALX3 - Homeobox protein aristaless-like 3 - Homo sapiens (Human) - ALX3 gene Transcriptional regulator with a possible role in patterning of mesoderm during development. Indicus|evm.model.CM009493.1.550 Q0P5J8 STRP1_BOVIN 100.000 0.997613 1.00119 STRIP1 - Striatin-interacting protein 1 - Bos taurus (Bovine) - STRIP1 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity). Indicus|evm.model.CM009493.1.551 Q80SW1 SAHH2_MOUSE 100.000 0.99619 0.990566 Ahcyl1 - S-adenosylhomocysteine hydrolase-like protein 1 - Mus musculus (Mouse) - Ahcyl1 gene Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (By similarity). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (By similarity). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (PubMed:12525476, PubMed:23542070). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:19224921). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (PubMed:19033647, PubMed:21317537). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2. Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition. May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state. Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (By similarity). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (PubMed:12525476). Indicus|evm.model.CM009493.1.552 P09603 CSF1_HUMAN 74.539 0.820669 1.18773 CSF1 - Macrophage colony-stimulating factor 1 precursor - Homo sapiens (Human) - CSF1 gene Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Indicus|evm.model.CM009493.1.553 Q8TE67 ES8L3_HUMAN 72.481 0.868243 0.499157 EPS8L3 - Epidermal growth factor receptor kinase substrate 8-like protein 3 - Homo sapiens (Human) - EPS8L3 gene cytoplasm, plasma membrane, ruffle membrane, actin binding, positive regulation of ruffle assembly, regulation of hair cycle, regulation of Rho protein signal transduction, Rho protein signal transduction Indicus|evm.model.CM009493.1.554 Q8TE67 ES8L3_HUMAN 82.014 0.985714 0.236088 EPS8L3 - Epidermal growth factor receptor kinase substrate 8-like protein 3 - Homo sapiens (Human) - EPS8L3 gene cytoplasm, plasma membrane, ruffle membrane, actin binding, positive regulation of ruffle assembly, regulation of hair cycle, regulation of Rho protein signal transduction, Rho protein signal transduction Indicus|evm.model.CM009493.1.555 Q8TE67 ES8L3_HUMAN 68.333 0.7 0.286678 EPS8L3 - Epidermal growth factor receptor kinase substrate 8-like protein 3 - Homo sapiens (Human) - EPS8L3 gene cytoplasm, plasma membrane, ruffle membrane, actin binding, positive regulation of ruffle assembly, regulation of hair cycle, regulation of Rho protein signal transduction, Rho protein signal transduction Indicus|evm.model.CM009493.1.556 Q9Z1B2 GSTM5_RAT 89.163 0.990196 0.906667 Gstm5 - Glutathione S-transferase Mu 5 - Rattus norvegicus (Rat) - Gstm5 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Indicus|evm.model.CM009493.1.557 Q9N0V4 GSTM1_BOVIN 88.073 0.990868 1.00459 GSTM1 - Glutathione S-transferase Mu 1 - Bos taurus (Bovine) - GSTM1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalyzed oxidative inactivation of enzymes. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers (By similarity). Indicus|evm.model.CM009493.1.558 Q9N0V4 GSTM1_BOVIN 100.000 0.990868 1.00459 GSTM1 - Glutathione S-transferase Mu 1 - Bos taurus (Bovine) - GSTM1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalyzed oxidative inactivation of enzymes. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers (By similarity). Indicus|evm.model.CM009493.1.559 Q9N0V4 GSTM1_BOVIN 98.165 0.990868 1.00459 GSTM1 - Glutathione S-transferase Mu 1 - Bos taurus (Bovine) - GSTM1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalyzed oxidative inactivation of enzymes. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers (By similarity). Indicus|evm.model.CM009493.1.560 Q9N0V4 GSTM1_BOVIN 86.239 0.990868 1.00459 GSTM1 - Glutathione S-transferase Mu 1 - Bos taurus (Bovine) - GSTM1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalyzed oxidative inactivation of enzymes. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers (By similarity). Indicus|evm.model.CM009493.1.561 P09488 GSTM1_HUMAN 85.780 0.990868 1.00459 GSTM1 - Glutathione S-transferase Mu 1 - Homo sapiens (Human) - GSTM1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Indicus|evm.model.CM009493.1.562 Q01433 AMPD2_HUMAN 97.337 0.997582 0.940842 AMPD2 - AMP deaminase 2 - Homo sapiens (Human) - AMPD2 gene AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. Indicus|evm.model.CM009493.1.563 P04696 GNAT2_BOVIN 99.718 0.994366 1.00282 GNAT2 - Guanine nucleotide-binding protein G(t) subunit alpha-2 - Bos taurus (Bovine) - GNAT2 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Indicus|evm.model.CM009493.1.564 P08754 GNAI3_HUMAN 98.870 0.994366 1.00282 GNAI3 - Guanine nucleotide-binding protein G(i) subunit alpha-3 - Homo sapiens (Human) - GNAI3 gene Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). Indicus|evm.model.CM009493.1.565 Q9BZJ8 GPR61_HUMAN 96.674 0.995575 1.00222 GPR61 - G-protein coupled receptor 61 - Homo sapiens (Human) - GPR61 gene Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity). Indicus|evm.model.CM009493.1.566 Q86WK6 AMGO1_HUMAN 94.523 0.995951 1.00203 AMIGO1 - Amphoterin-induced protein 1 precursor - Homo sapiens (Human) - AMIGO1 gene Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Indicus|evm.model.CM009493.1.567 Q8N8Q1 C56D1_HUMAN 93.886 0.991304 1.00437 CYB561D1 - Probable transmembrane reductase CYB561D1 - Homo sapiens (Human) - CYB561D1 gene Probable transmembrane reductase that may use ascorbate as an electron donor and transfer electrons across membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in another cellular compartment. Indicus|evm.model.CM009493.1.568 Q5T6C5 AT7L2_HUMAN 86.296 0.974801 1.04432 ATXN7L2 - Ataxin-7-like protein 2 - Homo sapiens (Human) - ATXN7L2 gene Indicus|evm.model.CM009493.1.569 O62646 SYPL2_RABIT 93.939 0.992453 1.00379 SYPL2 - Synaptophysin-like protein 2 - Oryctolagus cuniculus (Rabbit) - SYPL2 gene Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes. Indicus|evm.model.CM009493.1.570 Q9Z2U1 PSA5_MOUSE 100.000 0.991736 1.00415 Psma5 - Proteasome subunit alpha type-5 - Mus musculus (Mouse) - Psma5 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Indicus|evm.model.CM009493.1.571 Q99523 SORT_HUMAN 96.027 0.969415 0.904934 SORT1 - Sortilin precursor - Homo sapiens (Human) - SORT1 gene Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. Indicus|evm.model.CM009493.1.572 Q29RJ9 PSRC1_BOVIN 99.377 0.47619 2.06135 PSRC1 - Proline/serine-rich coiled-coil protein 1 - Bos taurus (Bovine) - PSRC1 gene Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity). Indicus|evm.model.CM009493.1.573 Q9QYP2 CELR2_RAT 96.322 0.735022 1.36241 Celsr2 - Cadherin EGF LAG seven-pass G-type receptor 2 - Rattus norvegicus (Rat) - Celsr2 gene Receptor that may have an important role in cell/cell signaling during nervous system formation. Indicus|evm.model.CM009493.1.574 Q9GMB8 SYSC_BOVIN 100.000 0.996117 1.00195 SARS1 - Serine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - SARS1 gene Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. Indicus|evm.model.CM009493.1.575 Q6UXG2 ELAP1_HUMAN 92.892 0.998028 1.00099 ELAPOR1 - Endosome/lysosome-associated apoptosis and autophagy regulator 1 precursor - Homo sapiens (Human) - ELAPOR1 gene May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway (PubMed:21072319). May play a role in apoptosis and cell proliferation through its interaction with HSPA5 (PubMed:26045166). Indicus|evm.model.CM009493.1.576 Q5T5A4 CA194_HUMAN 83.529 0.988304 1.01183 C1orf194 - Protein C1orf194 - Homo sapiens (Human) - C1orf194 gene May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis (PubMed:31199454). Indicus|evm.model.CM009493.1.577 Q5R9W6 TAF13_PONAB 100.000 0.984 1.00806 TAF13 - Transcription initiation factor TFIID subunit 13 - Pongo abelii (Sumatran orangutan) - TAF13 gene Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells (By similarity). Indicus|evm.model.CM009493.1.578 O94967 WDR47_HUMAN 97.280 0.924471 1.08052 WDR47 - WD repeat-containing protein 47 - Homo sapiens (Human) - WDR47 gene Indicus|evm.model.CM009493.1.579 Q1LZF8 CLCC1_BOVIN 100.000 0.996317 1.00185 CLCC1 - Chloride channel CLIC-like protein 1 precursor - Bos taurus (Bovine) - CLCC1 gene Seems to act as a chloride ion channel (By similarity). Plays a role in retina development (By similarity). Indicus|evm.model.CM009493.1.580 Q8VDU0 GPSM2_MOUSE 91.615 0.880658 1.07364 Gpsm2 - G-protein-signaling modulator 2 - Mus musculus (Mouse) - Gpsm2 gene Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions (PubMed:12571286, PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (PubMed:22952234). Indicus|evm.model.CM009493.1.581 Q5T1N1 AKND1_HUMAN 63.429 0.691176 0.894737 AKNAD1 - Protein AKNAD1 - Homo sapiens (Human) - AKNAD1 gene Indicus|evm.model.CM009493.1.582 O00186 STXB3_HUMAN 94.257 0.371932 2.68412 STXBP3 - Syntaxin-binding protein 3 - Homo sapiens (Human) - STXBP3 gene Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. Indicus|evm.model.CM009493.1.583 Q5VTL8 PR38B_HUMAN 96.154 0.996324 0.996337 PRPF38B - Pre-mRNA-splicing factor 38B - Homo sapiens (Human) - PRPF38B gene May be required for pre-mRNA splicing. Indicus|evm.model.CM009493.1.584 Q4R3W5 HENMT_MACFA 60.052 0.736842 1.30534 HENMT1 - Small RNA 2'-O-methyltransferase - Macaca fascicularis (Crab-eating macaque) - HENMT1 gene Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. Indicus|evm.model.CM009493.1.585 Q5T8I3 F102B_HUMAN 94.444 0.99446 1.00278 FAM102B - Protein FAM102B - Homo sapiens (Human) - FAM102B gene Indicus|evm.model.CM009493.1.586 O18757 SCMC1_RABIT 54.865 0.947781 0.806316 SLC25A24 - Calcium-binding mitochondrial carrier protein SCaMC-1 - Oryctolagus cuniculus (Rabbit) - SLC25A24 gene Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix (By similarity). Indicus|evm.model.CM009493.1.587 A5PJZ1 SCMC1_BOVIN 50.209 0.995475 0.926625 SLC25A24 - Calcium-binding mitochondrial carrier protein SCaMC-1 - Bos taurus (Bovine) - SLC25A24 gene Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity). Indicus|evm.model.CM009493.1.588 A5PJZ1 SCMC1_BOVIN 89.308 0.995338 0.899371 SLC25A24 - Calcium-binding mitochondrial carrier protein SCaMC-1 - Bos taurus (Bovine) - SLC25A24 gene Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity). Indicus|evm.model.CM009493.1.589 Q9UKW4 VAV3_HUMAN 96.340 0.890526 1.12161 VAV3 - Guanine nucleotide exchange factor VAV3 - Homo sapiens (Human) - VAV3 gene Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). Indicus|evm.model.CM009493.1.590 Q9Z0R6 ITSN2_MOUSE 95.014 0.897756 0.241712 Itsn2 - Intersectin-2 - Mus musculus (Mouse) - Itsn2 gene Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. Indicus|evm.model.CM009493.1.592 Q5E9L5 ANM6_BOVIN 100.000 0.994681 1.00267 PRMT6 - Protein arginine N-methyltransferase 6 - Bos taurus (Bovine) - PRMT6 gene Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (By similarity). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. Methylates GPS2, protecting GPS2 from ubiquitination and degradation. Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (By similarity). Indicus|evm.model.CM009493.1.593 P18203 FKB1A_BOVIN 96.296 0.981651 1.00926 FKBP1A - Peptidyl-prolyl cis-trans isomerase FKBP1A - Bos taurus (Bovine) - FKBP1A gene Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Indicus|evm.model.CM009493.1.595 D4AAZ6 RL37A_RAT 60.656 0.980392 0.708333 Rpl37a - 60S ribosomal protein L37a - Rattus norvegicus (Rat) - Rpl37a gene cytosolic large ribosomal subunit, large ribosomal subunit rRNA binding Indicus|evm.model.CM009493.1.596 P81134 RENR_BOVIN 88.983 0.959016 0.347578 ATP6AP2 - Renin receptor precursor - Bos taurus (Bovine) - ATP6AP2 gene Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (v-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Involved in many neuronal processes including synapse morphology and synaptic transmission (By similarity). Indicus|evm.model.CM009493.1.598 P19961 AMY2B_HUMAN 88.454 0.996094 1.00196 AMY2B - Alpha-amylase 2B precursor - Homo sapiens (Human) - AMY2B gene extracellular exosome, alpha-amylase activity Indicus|evm.model.CM009493.1.599 P19961 AMY2B_HUMAN 86.106 0.996094 1.00196 AMY2B - Alpha-amylase 2B precursor - Homo sapiens (Human) - AMY2B gene extracellular exosome, alpha-amylase activity Indicus|evm.model.CM009493.1.602 Q3MHP0 RNPC3_BOVIN 99.226 0.996139 1.00388 RNPC3 - RNA-binding region-containing protein 3 - Bos taurus (Bovine) - RNPC3 gene Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA (By similarity). Indicus|evm.model.CM009493.1.603 Q2KIU7 RSPH9_BOVIN 98.611 0.866667 0.597826 RSPH9 - Radial spoke head protein 9 homolog - Bos taurus (Bovine) - RSPH9 gene Component of the axonemal radial spoke head which plays an important role in ciliary motility (By similarity). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (By similarity). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (By similarity). Indicus|evm.model.CM009493.1.605 Q28083 COBA1_BOVIN 97.692 0.564997 1.73106 COL11A1 - Collagen alpha-1(XI) chain precursor - Bos taurus (Bovine) - COL11A1 gene May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. Indicus|evm.model.CM009493.1.606 Q3ZBM4 ITBP1_BOVIN 81.481 0.908046 0.435 ITGB1BP1 - Integrin beta-1-binding protein 1 - Bos taurus (Bovine) - ITGB1BP1 gene Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter (By similarity). Indicus|evm.model.CM009493.1.607 P68105 EF1A1_RABIT 80.818 0.936709 0.683983 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009493.1.608 P63057 NOE3_RAT 99.163 0.995825 1.00209 Olfm3 - Noelin-3 precursor - Rattus norvegicus (Rat) - Olfm3 gene AMPA glutamate receptor complex, extracellular space, Golgi apparatus, eye photoreceptor cell development Indicus|evm.model.CM009493.1.609 Q5E9P3 S1PR1_BOVIN 100.000 0.994778 1.00262 S1PR1 - Sphingosine 1-phosphate receptor 1 - Bos taurus (Bovine) - S1PR1 gene G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury (By similarity). Indicus|evm.model.CM009493.1.610 Q5E982 DPH5_BOVIN 99.649 0.993007 1.00351 DPH5 - Diphthine methyl ester synthase - Bos taurus (Bovine) - DPH5 gene S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. Indicus|evm.model.CM009493.1.611 Q9JKN1 ZNT7_MOUSE 97.015 0.677966 0.780423 Slc30a7 - Zinc transporter 7 - Mus musculus (Mouse) - Slc30a7 gene Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity). Indicus|evm.model.CM009493.1.612 Q9ES89 EXTL2_MOUSE 87.879 0.993958 1.00303 Extl2 - Exostosin-like 2 - Mus musculus (Mouse) - Extl2 gene Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Indicus|evm.model.CM009493.1.613 Q28260 VCAM1_CANLF 78.697 0.994595 1.00135 VCAM1 - Vascular cell adhesion protein 1 precursor - Canis lupus familiaris (Dog) - VCAM1 gene Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation (By similarity). Indicus|evm.model.CM009493.1.614 Q28260 VCAM1_CANLF 78.108 0.997301 1.00271 VCAM1 - Vascular cell adhesion protein 1 precursor - Canis lupus familiaris (Dog) - VCAM1 gene Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation (By similarity). Indicus|evm.model.CM009493.1.615 Q9GZN0 GPR88_HUMAN 97.135 0.994792 1 GPR88 - Probable G-protein coupled receptor 88 - Homo sapiens (Human) - GPR88 gene Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function. Indicus|evm.model.CM009493.1.616 Q9UNH5 CC14A_HUMAN 92.953 0.99665 1.00505 CDC14A - Dual specificity protein phosphatase CDC14A - Homo sapiens (Human) - CDC14A gene Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). Indicus|evm.model.CM009493.1.617 P63159 HMGB1_RAT 84.472 0.952096 0.776744 Hmgb1 - High mobility group protein B1 - Rattus norvegicus (Rat) - Hmgb1 gene Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide (PubMed:11154118). Bound to RAGE mediates signaling for neuronal outgrowth (PubMed:1885601, PubMed:2461949, PubMed:7592757, PubMed:12183440). May play a role in accumulation of expanded polyglutamine (polyQ) proteins. Indicus|evm.model.CM009493.1.618 Q2HJ88 RTCA_BOVIN 99.727 0.99455 1.00273 RTCA - RNA 3'-terminal phosphate cyclase - Bos taurus (Bovine) - RTCA gene Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity). Indicus|evm.model.CM009493.1.619 P11181 ODB2_BOVIN 99.793 0.995859 1.00207 DBT - Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor - Bos taurus (Bovine) - DBT gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. Indicus|evm.model.CM009493.1.620 Q5XGD9 ARI3A_XENTR 59.871 0.6 0.804067 arid3a - AT-rich interactive domain-containing protein 3A - Xenopus tropicalis (Western clawed frog) - arid3a gene Transcription factor required for smad1 and smad2-mediated responses to TGFbeta during mesoderm induction. Indicus|evm.model.CM009493.1.621 Q3ZC49 LRC39_BOVIN 100.000 0.99403 1.00299 LRRC39 - Leucine-rich repeat-containing protein 39 - Bos taurus (Bovine) - LRRC39 gene Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart. Indicus|evm.model.CM009493.1.622 Q9NUP7 TRM13_HUMAN 90.644 0.995851 1.00208 TRMT13 - tRNA:m(4)X modification enzyme TRM13 homolog - Homo sapiens (Human) - TRMT13 gene tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). Indicus|evm.model.CM009493.1.623 Q6UVJ0 SAS6_HUMAN 92.237 0.99696 1.00152 SASS6 - Spindle assembly abnormal protein 6 homolog - Homo sapiens (Human) - SASS6 gene Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). Indicus|evm.model.CM009493.1.624 P70187 MF14A_MOUSE 99.796 0.995927 1.00204 Mfsd14a - Hippocampus abundant transcript 1 protein - Mus musculus (Mouse) - Mfsd14a gene acrosome assembly, sperm mitochondrion organization, spermatid development, spermatid nucleus differentiation, spermatogenesis Indicus|evm.model.CM009493.1.625 Q6YC49 S35A3_BOVIN 100.000 0.766509 1.30061 SLC35A3 - UDP-N-acetylglucosamine transporter - Bos taurus (Bovine) - SLC35A3 gene Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides (By similarity). Indicus|evm.model.CM009493.1.626 Q2PQH8 GDE_CANLF 93.085 0.998695 1 AGL - Glycogen debranching enzyme - Canis lupus familiaris (Dog) - AGL gene Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. Indicus|evm.model.CM009493.1.627 A2VE04 FRRS1_BOVIN 99.605 0.958175 0.445008 FRRS1 - Ferric-chelate reductase 1 - Bos taurus (Bovine) - FRRS1 gene Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Indicus|evm.model.CM009493.1.628 A2VE04 FRRS1_BOVIN 100.000 0.993355 0.509306 FRRS1 - Ferric-chelate reductase 1 - Bos taurus (Bovine) - FRRS1 gene Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Indicus|evm.model.CM009493.1.629 Q3MHH7 PALMD_BOVIN 99.636 0.99637 1.00182 PALMD - Palmdelphin - Bos taurus (Bovine) - PALMD gene cytoplasm Indicus|evm.model.CM009493.1.631 Q7Z2D5 PLPR4_HUMAN 97.765 0.997211 0.939712 PLPPR4 - 2-lysophosphatidate phosphatase PLPPR4 - Homo sapiens (Human) - PLPPR4 gene Hydrolyzes lysophosphatidic acid (LPA) and participates to the axonal outgrowth during development by attenuating phospholipid-induced axon collapse in neuron. Indicus|evm.model.CM009493.1.632 Q32ZL2 PLPR5_HUMAN 99.038 0.9 0.716511 PLPPR5 - Phospholipid phosphatase-related protein type 5 - Homo sapiens (Human) - PLPPR5 gene Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction. Indicus|evm.model.CM009493.1.633 Q1RMM1 ZC3HF_BOVIN 98.826 0.995316 1.00235 ZC3H15 - Zinc finger CCCH domain-containing protein 15 - Bos taurus (Bovine) - ZC3H15 gene Protects DRG1 from proteolytic degradation. Indicus|evm.model.CM009493.1.634 Q6GM05 PLPR5_XENLA 83.333 0.77931 0.461783 plppr5 - Phospholipid phosphatase-related protein type 5 - Xenopus laevis (African clawed frog) - plppr5 gene Induces filopodia formation and promotes neurite growth. Indicus|evm.model.CM009493.1.635 Q9UNH6 SNX7_HUMAN 94.301 0.815678 1.21964 SNX7 - Sorting nexin-7 - Homo sapiens (Human) - SNX7 gene May be involved in several stages of intracellular trafficking. Indicus|evm.model.CM009493.1.636 Q95KF9 NO40_MACFA 84.000 0.827586 0.300518 ZCCHC17 - Nucleolar protein of 40 kDa - Macaca fascicularis (Crab-eating macaque) - ZCCHC17 gene Indicus|evm.model.CM009493.1.637 Q28007 DPYD_BOVIN 100.000 0.622951 0.119024 DPYD - Dihydropyrimidine dehydrogenase [NADP(+)] - Bos taurus (Bovine) - DPYD gene Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Indicus|evm.model.CM009493.1.638 Q28007 DPYD_BOVIN 96.377 0.995146 0.401951 DPYD - Dihydropyrimidine dehydrogenase [NADP(+)] - Bos taurus (Bovine) - DPYD gene Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Indicus|evm.model.CM009493.1.639 Q28007 DPYD_BOVIN 99.191 0.929648 0.388293 DPYD - Dihydropyrimidine dehydrogenase [NADP(+)] - Bos taurus (Bovine) - DPYD gene Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Indicus|evm.model.CM009493.1.640 Q9UKA9 PTBP2_HUMAN 86.278 0.995736 0.883239 PTBP2 - Polypyrimidine tract-binding protein 2 - Homo sapiens (Human) - PTBP2 gene RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. Indicus|evm.model.CM009493.1.643 A3KN24 RWDD3_BOVIN 98.876 0.992537 1.00375 RWDD3 - RWD domain-containing protein 3 - Bos taurus (Bovine) - RWDD3 gene Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Has no effect on ubiquitination (By similarity). Indicus|evm.model.CM009493.1.644 Q96MV1 TLCD4_HUMAN 74.545 0.931818 0.669202 TLCD4 - TLC domain-containing protein 4 - Homo sapiens (Human) - TLCD4 gene endoplasmic reticulum, lipid homeostasis Indicus|evm.model.CM009493.1.646 Q96F25 ALG14_HUMAN 73.077 0.793814 0.449074 ALG14 - UDP-N-acetylglucosamine transferase subunit ALG14 homolog - Homo sapiens (Human) - ALG14 gene May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. Indicus|evm.model.CM009493.1.647 Q32L92 CNN3_BOVIN 100.000 0.993939 1.00304 CNN3 - Calponin-3 - Bos taurus (Bovine) - CNN3 gene Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). Indicus|evm.model.CM009493.1.648 A5PK40 CTL3_BOVIN 86.997 0.949838 0.952234 SLC44A3 - Choline transporter-like protein 3 - Bos taurus (Bovine) - SLC44A3 gene membrane, transmembrane transporter activity, transmembrane transport Indicus|evm.model.CM009493.1.649 P30931 TF_BOVIN 99.315 0.993174 1.00342 F3 - Tissue factor precursor - Bos taurus (Bovine) - F3 gene Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Indicus|evm.model.CM009493.1.650 P28288 ABCD3_HUMAN 94.385 0.996956 0.996965 ABCD3 - ATP-binding cassette sub-family D member 3 - Homo sapiens (Human) - ABCD3 gene Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382). The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (PubMed:11248239). Indicus|evm.model.CM009493.1.651 A7YY57 RHG29_BOVIN 99.842 0.998425 1.00079 ARHGAP29 - Rho GTPase-activating protein 29 - Bos taurus (Bovine) - ARHGAP29 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity). Indicus|evm.model.CM009493.1.652 P78363 ABCA4_HUMAN 87.857 0.994671 0.990761 ABCA4 - Retinal-specific phospholipid-transporting ATPase ABCA4 - Homo sapiens (Human) - ABCA4 gene Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylethanolamine (PubMed:24097981). In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. Indicus|evm.model.CM009493.1.653 Q2T9Y6 GSH0_BOVIN 99.635 0.992727 1.00365 GCLM - Glutamate--cysteine ligase regulatory subunit - Bos taurus (Bovine) - GCLM gene glutamate-cysteine ligase complex, enzyme regulator activity, glutamate-cysteine ligase catalytic subunit binding, blood vessel diameter maintenance, glutamate metabolic process, glutathione biosynthetic process, positive regulation of glutamate-cysteine ligase activity, response to drug, response to oxidative stress Indicus|evm.model.CM009493.1.654 Q0P5H2 TDIF2_BOVIN 99.869 0.997392 1.00131 DNTTIP2 - Deoxynucleotidyltransferase terminal-interacting protein 2 - Bos taurus (Bovine) - DNTTIP2 gene Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (By similarity). Indicus|evm.model.CM009493.1.655 Q58DL5 BCAR3_BOVIN 99.879 0.997582 1.00121 BCAR3 - Breast cancer anti-estrogen resistance protein 3 homolog - Bos taurus (Bovine) - BCAR3 gene Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity. May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling. Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA. Positively regulates integrin-induced tyrosine phosphorylation of BCAR1. Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity). Indicus|evm.model.CM009493.1.656 Q2HWF0 FBP1L_RAT 87.769 0.99635 0.905785 Fnbp1l - Formin-binding protein 1-like - Rattus norvegicus (Rat) - Fnbp1l gene Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity). May negatively regulate neurite extension and axon branching in developing neurons. Indicus|evm.model.CM009493.1.657 Q01658 NC2B_HUMAN 100.000 0.988701 1.00568 DR1 - Protein Dr1 - Homo sapiens (Human) - DR1 gene The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Indicus|evm.model.CM009493.1.659 Q5E9E2 MYL9_BOVIN 58.451 0.978261 0.534884 MYL9 - Myosin regulatory light polypeptide 9 - Bos taurus (Bovine) - MYL9 gene Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). Indicus|evm.model.CM009493.1.660 Q5T9S5 CCD18_HUMAN 89.890 0.971888 1.02751 CCDC18 - Coiled-coil domain-containing protein 18 - Homo sapiens (Human) - CCDC18 gene Indicus|evm.model.CM009493.1.661 Q2KJ84 TMED5_BOVIN 100.000 0.991189 1.00442 TMED5 - Transmembrane emp24 domain-containing protein 5 precursor - Bos taurus (Bovine) - TMED5 gene Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity). Indicus|evm.model.CM009493.1.662 Q5R7T9 MTF2_PONAB 99.325 0.996633 1.00169 MTF2 - Metal-response element-binding transcription factor 2 - Pongo abelii (Sumatran orangutan) - MTF2 gene Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (By similarity). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). Indicus|evm.model.CM009493.1.663 Q5R634 DIK1A_PONAB 100.000 0.981132 0.866822 DIPK1A - Divergent protein kinase domain 1A - Pongo abelii (Sumatran orangutan) - DIPK1A gene Indicus|evm.model.CM009493.1.664 Q58DW5 RL5_BOVIN 100.000 0.719577 1.27273 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Indicus|evm.model.CM009493.1.665 Q96CN4 EVI5L_HUMAN 70.153 0.946731 1.0403 EVI5L - EVI5-like protein - Homo sapiens (Human) - EVI5L gene Functions as a GTPase-activating protein (GAP) with a broad specificity. Indicus|evm.model.CM009493.1.666 Q07120 GFI1_RAT 99.315 0.323661 1.0591 Gfi1 - Zinc finger protein Gfi-1 - Rattus norvegicus (Rat) - Gfi1 gene Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 promoter region. Implicated in the maintenance of inner ear hair cells (By similarity). Indicus|evm.model.CM009493.1.667 F6RRD7 RPAP2_BOVIN 99.836 0.996716 1.00164 RPAP2 - Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 - Bos taurus (Bovine) - RPAP2 gene Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Indicus|evm.model.CM009493.1.668 Q92990 GLMN_HUMAN 89.545 0.996627 0.998316 GLMN - Glomulin - Homo sapiens (Human) - GLMN gene Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281). Indicus|evm.model.CM009493.1.669 Q2TA05 SPO16_BOVIN 100.000 0.989011 1.00552 SPO16 - Protein SPO16 homolog - Bos taurus (Bovine) - SPO16 gene Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells (By similarity). Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 (By similarity). Required for the localization of TEX11 and MSH4 to recombination intermediates (By similarity). Indicus|evm.model.CM009493.1.670 Q5XKL5 BTBD8_HUMAN 81.395 0.214008 4.75926 BTBD8 - BTB/POZ domain-containing protein 8 - Homo sapiens (Human) - BTBD8 gene nucleoplasm Indicus|evm.model.CM009493.1.671 Q4V8A1 PCT2B_RAT 76.459 0.873016 1.09671 Lpcat2b - Lysophosphatidylcholine acyltransferase 2B - Rattus norvegicus (Rat) - Lpcat2b gene Probable acetyltransferase. Indicus|evm.model.CM009493.1.672 Q8IUS5 EPHX4_HUMAN 93.094 0.99449 1.00276 EPHX4 - Epoxide hydrolase 4 - Homo sapiens (Human) - EPHX4 gene hydrolase activity Indicus|evm.model.CM009493.1.673 Q4R8Y1 BRDT_MACFA 81.092 0.992521 0.988384 BRDT - Bromodomain testis-specific protein - Macaca fascicularis (Crab-eating macaque) - BRDT gene Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. Indicus|evm.model.CM009493.1.674 Q03167 TGBR3_HUMAN 87.427 0.987194 1.0094 TGFBR3 - Transforming growth factor beta receptor type 3 precursor - Homo sapiens (Human) - TGFBR3 gene Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Indicus|evm.model.CM009493.1.676 O00311 CDC7_HUMAN 89.062 0.996534 1.00523 CDC7 - Cell division cycle 7-related protein kinase - Homo sapiens (Human) - CDC7 gene Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylate MCM2 and MCM3. Indicus|evm.model.CM009493.1.677 A2PYH4 HFM1_HUMAN 83.611 0.99858 0.981185 HFM1 - Probable ATP-dependent DNA helicase HFM1 - Homo sapiens (Human) - HFM1 gene Required for crossover formation and complete synapsis of homologous chromosomes during meiosis. Indicus|evm.model.CM009493.1.678 A5A6H5 ATPA_PANTR 80.233 0.923913 0.166365 ATP5F1A - ATP synthase subunit alpha, mitochondrial precursor - Pan troglodytes (Chimpanzee) - ATP5F1A gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). Indicus|evm.model.CM009493.1.679 Q9H582 ZN644_HUMAN 92.540 0.998494 1.00075 ZNF644 - Zinc finger protein 644 - Homo sapiens (Human) - ZNF644 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009493.1.680 Q8VIB5 BARH2_MOUSE 94.226 0.994751 0.992188 Barhl2 - BarH-like 2 homeobox protein - Mus musculus (Mouse) - Barhl2 gene Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity). Indicus|evm.model.CM009493.1.683 F1MJM0 ZN326_BOVIN 100.000 0.996552 1.00173 ZNF326 - DBIRD complex subunit ZNF326 - Bos taurus (Bovine) - ZNF326 gene Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro (By similarity). Indicus|evm.model.CM009493.1.684 Q7L1W4 LRC8D_HUMAN 97.086 0.753076 1.32634 LRRC8D - Volume-regulated anion channel subunit LRRC8D - Homo sapiens (Human) - LRRC8D gene Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309). Indicus|evm.model.CM009493.1.685 A5PK13 LRC8C_BOVIN 100.000 0.997512 1.00125 LRRC8C - Volume-regulated anion channel subunit LRRC8C - Bos taurus (Bovine) - LRRC8C gene Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Indicus|evm.model.CM009493.1.686 Q6P9F7 LRC8B_HUMAN 97.139 0.997516 1.00249 LRRC8B - Volume-regulated anion channel subunit LRRC8B - Homo sapiens (Human) - LRRC8B gene Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Indicus|evm.model.CM009493.1.687 Q6ZN66 GBP6_HUMAN 77.759 0.474152 1.95577 GBP6 - Guanylate-binding protein 6 - Homo sapiens (Human) - GBP6 gene Binds GTP, GDP and GMP. Indicus|evm.model.CM009493.1.688 Q6ZN66 GBP6_HUMAN 74.841 0.99682 0.993681 GBP6 - Guanylate-binding protein 6 - Homo sapiens (Human) - GBP6 gene Binds GTP, GDP and GMP. Indicus|evm.model.CM009493.1.689 Q6ZN66 GBP6_HUMAN 72.727 0.996815 0.992101 GBP6 - Guanylate-binding protein 6 - Homo sapiens (Human) - GBP6 gene Binds GTP, GDP and GMP. Indicus|evm.model.CM009493.1.690 Q96PP8 GBP5_HUMAN 70.478 0.993186 1.00171 GBP5 - Guanylate-binding protein 5 precursor - Homo sapiens (Human) - GBP5 gene As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847). Indicus|evm.model.CM009493.1.691 Q5D1D6 GBP1_CHLAE 84.095 0.996622 1.00339 GBP1 - Guanylate-binding protein 1 precursor - Chlorocebus aethiops (Green monkey) - GBP1 gene Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Indicus|evm.model.CM009493.1.692 P32456 GBP2_HUMAN 78.261 0.46559 1.99154 GBP2 - Guanylate-binding protein 2 precursor - Homo sapiens (Human) - GBP2 gene Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Indicus|evm.model.CM009493.1.693 Q61107 GBP4_MOUSE 74.074 0.0419304 2.03871 Gbp4 - Guanylate-binding protein 4 - Mus musculus (Mouse) - Gbp4 gene Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation. Indicus|evm.model.CM009493.1.694 Q5D1D6 GBP1_CHLAE 66.034 0.982592 0.876271 GBP1 - Guanylate-binding protein 1 precursor - Chlorocebus aethiops (Green monkey) - GBP1 gene Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Indicus|evm.model.CM009493.1.695 Q96PP9 GBP4_HUMAN 67.496 0.959807 0.971875 GBP4 - Guanylate-binding protein 4 - Homo sapiens (Human) - GBP4 gene Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity). Indicus|evm.model.CM009493.1.696 Q61107 GBP4_MOUSE 69.216 0.435726 1.93226 Gbp4 - Guanylate-binding protein 4 - Mus musculus (Mouse) - Gbp4 gene Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation. Indicus|evm.model.CM009493.1.697 Q5D1D6 GBP1_CHLAE 79.365 0.596154 0.176271 GBP1 - Guanylate-binding protein 1 precursor - Chlorocebus aethiops (Green monkey) - GBP1 gene Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Indicus|evm.model.CM009493.1.699 Q96PP9 GBP4_HUMAN 70.418 0.380135 2.54844 GBP4 - Guanylate-binding protein 4 - Homo sapiens (Human) - GBP4 gene Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity). Indicus|evm.model.CM009493.1.700 Q5D1D6 GBP1_CHLAE 84.576 0.994932 1.00339 GBP1 - Guanylate-binding protein 1 precursor - Chlorocebus aethiops (Green monkey) - GBP1 gene Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Indicus|evm.model.CM009493.1.701 Q0P5G4 KAT3_BOVIN 99.780 0.995614 1.0022 KYAT3 - Kynurenine--oxoglutarate transaminase 3 - Bos taurus (Bovine) - KYAT3 gene Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). Indicus|evm.model.CM009493.1.702 Q5R886 TF2B_PONAB 100.000 0.993691 1.00316 GTF2B - Transcription initiation factor IIB - Pongo abelii (Sumatran orangutan) - GTF2B gene General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Exhibits also autoacetyltransferase activity that contributes to the activated transcription. Indicus|evm.model.CM009493.1.703 Q16513 PKN2_HUMAN 97.053 0.997963 0.997967 PKN2 - Serine/threonine-protein kinase N2 - Homo sapiens (Human) - PKN2 gene PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). Indicus|evm.model.CM009493.1.706 O97552 PO5F1_BOVIN 52.586 0.798077 0.288889 POU5F1 - POU domain, class 5, transcription factor 1 - Bos taurus (Bovine) - POU5F1 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Indicus|evm.model.CM009493.1.707 P61969 LMO4_MOUSE 100.000 0.987952 1.00606 Lmo4 - LIM domain transcription factor LMO4 - Mus musculus (Mouse) - Lmo4 gene Probable transcriptional factor. Indicus|evm.model.CM009493.1.708 P14206 RSSA_MOUSE 77.778 0.632653 0.332203 Rpsa - 40S ribosomal protein SA - Mus musculus (Mouse) - Rpsa gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Enables malignant tumor cells to penetrate laminin tissue and vessel barriers. Activates precursor thymic anti-OFA/iLRP specific cytotoxic T-cell. May induce CD8 T-suppressor cells secreting IL-10. Indicus|evm.model.CM009493.1.709 Q9D6Y1 CCDC3_MOUSE 71.111 0.4 0.40293 Ccdc3 - Coiled-coil domain-containing protein 3 precursor - Mus musculus (Mouse) - Ccdc3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells (PubMed:25605713). Indicus|evm.model.CM009493.1.710 Q9UPS8 ANR26_HUMAN 72.603 0.517986 0.0812865 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009493.1.711 Q7LGA3 HS2ST_HUMAN 98.322 0.993311 0.839888 HS2ST1 - Heparan sulfate 2-O-sulfotransferase 1 - Homo sapiens (Human) - HS2ST1 gene Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Indicus|evm.model.CM009493.1.712 Q7LGA3 HS2ST_HUMAN 100.000 0.56338 0.199438 HS2ST1 - Heparan sulfate 2-O-sulfotransferase 1 - Homo sapiens (Human) - HS2ST1 gene Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Indicus|evm.model.CM009493.1.713 Q32P51 RA1L2_HUMAN 88.235 0.437908 0.478125 HNRNPA1L2 - Heterogeneous nuclear ribonucleoprotein A1-like 2 - Homo sapiens (Human) - HNRNPA1L2 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. Indicus|evm.model.CM009493.1.714 Q0P5L0 RBM42_BOVIN 98.571 0.757246 0.616071 RBM42 - RNA-binding protein 42 - Bos taurus (Bovine) - RBM42 gene Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. Indicus|evm.model.CM009493.1.715 Q32LM0 SHLB1_BOVIN 89.488 0.966057 1.04932 SH3GLB1 - Endophilin-B1 - Bos taurus (Bovine) - SH3GLB1 gene May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Indicus|evm.model.CM009493.1.716 P54281 CLCA1_BOVIN 99.889 0.997788 1.00111 Calcium-activated chloride channel regulator 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009493.1.717 P54281 CLCA1_BOVIN 88.496 0.996689 1.00332 Calcium-activated chloride channel regulator 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009493.1.718 Q14CN2 CLCA4_HUMAN 74.919 0.980728 1.01632 CLCA4 - Calcium-activated chloride channel regulator 4 precursor - Homo sapiens (Human) - CLCA4 gene May be involved in mediating calcium-activated chloride conductance. Indicus|evm.model.CM009493.1.719 Q2TU62 CLCA1_HORSE 82.986 0.997802 0.996714 CLCA1 - Calcium-activated chloride channel regulator 1 precursor - Equus caballus (Horse) - CLCA1 gene May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC (By similarity). Indicus|evm.model.CM009493.1.720 Q9UQC9 CLCA2_HUMAN 81.033 0.921283 1.0912 CLCA2 - Calcium-activated chloride channel regulator 2 precursor - Homo sapiens (Human) - CLCA2 gene Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. Indicus|evm.model.CM009493.1.721 Q0VBY1 ODF2L_BOVIN 94.171 0.996317 0.990876 ODF2L - Protein BCAP - Bos taurus (Bovine) - ODF2L gene Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis. Indicus|evm.model.CM009493.1.722 Q17RW2 COOA1_HUMAN 72.843 0.950311 0.187865 COL24A1 - Collagen alpha-1(XXIV) chain precursor - Homo sapiens (Human) - COL24A1 gene May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. Indicus|evm.model.CM009493.1.724 Q1RML4 SPIC_BOVIN 94.643 0.873016 1.01613 SPIC - Transcription factor Spi-C - Bos taurus (Bovine) - SPIC gene Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). Indicus|evm.model.CM009493.1.725 Q9NWK9 BCD1_HUMAN 77.474 0.995754 1.00213 ZNHIT6 - Box C/D snoRNA protein 1 - Homo sapiens (Human) - ZNHIT6 gene Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. Indicus|evm.model.CM009493.1.727 O00622 CCN1_HUMAN 92.932 0.994778 1.00525 CCN1 - CCN family member 1 precursor - Homo sapiens (Human) - CCN1 gene Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Indicus|evm.model.CM009493.1.728 P56965 DDAH1_BOVIN 95.327 0.566845 0.65614 DDAH1 - N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 - Bos taurus (Bovine) - DDAH1 gene Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. Indicus|evm.model.CM009493.1.729 P56965 DDAH1_BOVIN 100.000 0.806167 0.796491 DDAH1 - N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 - Bos taurus (Bovine) - DDAH1 gene Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. Indicus|evm.model.CM009493.1.730 O95999 BCL10_HUMAN 95.279 0.991342 0.991416 BCL10 - B-cell lymphoma/leukemia 10 - Homo sapiens (Human) - BCL10 gene Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:25365219, PubMed:24074955). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:27777308, PubMed:24074955). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:27777308, PubMed:24074955). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). Indicus|evm.model.CM009493.1.731 Q32LF5 CA052_BOVIN 100.000 0.989071 1.00549 UPF0690 protein C1orf52 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009493.1.732 Q5VT97 SYDE2_HUMAN 83.319 0.819627 1.21189 SYDE2 - Rho GTPase-activating protein SYDE2 - Homo sapiens (Human) - SYDE2 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009493.1.733 Q8IWG1 DNAI3_HUMAN 85.650 0.99776 1.00224 DNAI3 - Dynein axonemal intermediate chain 3 - Homo sapiens (Human) - DNAI3 gene Acts as a negative regulator of cell migration, invasion, and metastasis downstream of p53/TP53, through inhibition of Arp2/3 complex-mediated actin polymerization (PubMed:32128961). Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function (By similarity). May play a role in osteogenesis of dental tissue-derived mesenchymal stem cells (By similarity). Indicus|evm.model.CM009493.1.734 Q8TDD5 MCLN3_HUMAN 92.948 0.951724 1.04882 MCOLN3 - Mucolipin-3 - Homo sapiens (Human) - MCOLN3 gene Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151). Indicus|evm.model.CM009493.1.735 Q8IZK6 MCLN2_HUMAN 84.794 0.975309 1.00177 MCOLN2 - Mucolipin-2 - Homo sapiens (Human) - MCOLN2 gene Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Indicus|evm.model.CM009493.1.736 Q9UBY5 LPAR3_HUMAN 90.960 0.99435 1.00283 LPAR3 - Lysophosphatidic acid receptor 3 - Homo sapiens (Human) - LPAR3 gene Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. Indicus|evm.model.CM009493.1.738 Q9Y2D8 ADIP_HUMAN 94.797 0.996753 1.00326 SSX2IP - Afadin- and alpha-actinin-binding protein - Homo sapiens (Human) - SSX2IP gene Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). Indicus|evm.model.CM009493.1.739 Q01458 DIAC_BOVIN 97.714 0.460317 2.16 CTBS - Di-N-acetylchitobiase precursor - Bos taurus (Bovine) - CTBS gene Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase. Indicus|evm.model.CM009493.1.740 Q9H9Y2 RPF1_HUMAN 95.415 0.994286 1.00287 RPF1 - Ribosome production factor 1 - Homo sapiens (Human) - RPF1 gene May be required for ribosome biogenesis. Indicus|evm.model.CM009493.1.741 Q8NGB4 OR4S1_HUMAN 82.000 0.792 0.404531 OR4S1 - Olfactory receptor 4S1 - Homo sapiens (Human) - OR4S1 gene Odorant receptor. Indicus|evm.model.CM009493.1.742 Q8WZ79 DNS2B_HUMAN 86.236 0.99162 0.99169 DNASE2B - Deoxyribonuclease-2-beta precursor - Homo sapiens (Human) - DNASE2B gene Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. Indicus|evm.model.CM009493.1.743 Q3MHG7 URIC_BOVIN 99.671 0.912651 1.09211 UOX - Uricase - Bos taurus (Bovine) - UOX gene Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Indicus|evm.model.CM009493.1.744 Q5VXD3 SAM13_HUMAN 94.872 0.982906 0.959016 SAMD13 - Sterile alpha motif domain-containing protein 13 - Homo sapiens (Human) - SAMD13 gene nucleus, chromatin binding, histone binding, negative regulation of transcription, DNA-templated Indicus|evm.model.CM009493.1.745 P05131 KAPCB_BOVIN 99.703 0.844221 1.1339 PRKACB - cAMP-dependent protein kinase catalytic subunit beta - Bos taurus (Bovine) - PRKACB gene Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Indicus|evm.model.CM009493.1.747 Q6ZT98 TTLL7_HUMAN 94.589 0.997748 1.00113 TTLL7 - Tubulin polyglutamylase TTLL7 - Homo sapiens (Human) - TTLL7 gene Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:25959773). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity). Indicus|evm.model.CM009493.1.750 O62829 PPM1A_BOVIN 98.917 0.992806 0.727749 PPM1A - Protein phosphatase 1A - Bos taurus (Bovine) - PPM1A gene Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). Indicus|evm.model.CM009493.1.751 O97817 AGRL2_BOVIN 97.632 0.998618 0.979026 ADGRL2 - Adhesion G protein-coupled receptor L2 precursor - Bos taurus (Bovine) - ADGRL2 gene Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Indicus|evm.model.CM009493.1.754 B1AR13 CISD3_MOUSE 82.759 0.398601 1.0438 Cisd3 - CDGSH iron-sulfur domain-containing protein 3, mitochondrial precursor - Mus musculus (Mouse) - Cisd3 gene Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function. Indicus|evm.model.CM009493.1.755 P15927 RFA2_HUMAN 88.259 0.878571 1.03704 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Indicus|evm.model.CM009493.1.756 Q96PZ7 CSMD1_HUMAN 91.429 0.896552 0.0325477 CSMD1 - CUB and sushi domain-containing protein 1 precursor - Homo sapiens (Human) - CSMD1 gene Potential suppressor of squamous cell carcinomas. Indicus|evm.model.CM009493.1.757 Q9HBW9 AGRL4_HUMAN 87.971 0.997101 1 ADGRL4 - Adhesion G protein-coupled receptor L4 precursor - Homo sapiens (Human) - ADGRL4 gene Endothelial orphan receptor that acts as a key regulator of angiogenesis. Indicus|evm.model.CM009493.1.758 P27473 IFI44_PANTR 60.981 0.935556 1.01351 IFI44 - Interferon-induced protein 44 - Pan troglodytes (Chimpanzee) - IFI44 gene This protein aggregates to form microtubular structures. Indicus|evm.model.CM009493.1.759 Q53G44 IF44L_HUMAN 63.122 0.995475 0.977876 IFI44L - Interferon-induced protein 44-like - Homo sapiens (Human) - IFI44L gene Exhibits a low antiviral activity against hepatitis C virus. Indicus|evm.model.CM009493.1.760 P37289 PF2R_BOVIN 99.724 0.99449 1.00276 PTGFR - Prostaglandin F2-alpha receptor - Bos taurus (Bovine) - PTGFR gene Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Indicus|evm.model.CM009493.1.762 P23403 RS20_XENLA 87.755 0.602564 0.655462 rps20 - 40S ribosomal protein S20 - Xenopus laevis (African clawed frog) - rps20 gene Indicus|evm.model.CM009493.1.763 Q56JY1 RL35A_BOVIN 96.591 0.977528 0.809091 RPL35A - 60S ribosomal protein L35a - Bos taurus (Bovine) - RPL35A gene Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation (By similarity). The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (By similarity). Indicus|evm.model.CM009493.1.764 Q1JQD4 GIPC2_BOVIN 99.681 0.993631 1.00319 GIPC2 - PDZ domain-containing protein GIPC2 - Bos taurus (Bovine) - GIPC2 gene Indicus|evm.model.CM009493.1.765 Q2KIT4 DNJB4_BOVIN 100.000 0.994083 1.00297 DNAJB4 - DnaJ homolog subfamily B member 4 - Bos taurus (Bovine) - DNAJB4 gene Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Indicus|evm.model.CM009493.1.766 Q96AE4 FUBP1_HUMAN 99.669 0.9 1.04037 FUBP1 - Far upstream element-binding protein 1 - Homo sapiens (Human) - FUBP1 gene Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. Indicus|evm.model.CM009493.1.767 Q0ZGT2 NEXN_HUMAN 93.759 0.992614 1.00296 NEXN - Nexilin - Homo sapiens (Human) - NEXN gene Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. Indicus|evm.model.CM009493.1.768 Q8NAN2 MIGA1_HUMAN 86.921 0.898089 0.993671 MIGA1 - Mitoguardin 1 - Homo sapiens (Human) - MIGA1 gene Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. Indicus|evm.model.CM009493.1.769 A6QNM7 UBP33_BOVIN 99.890 0.997809 1.0011 USP33 - Ubiquitin carboxyl-terminal hydrolase 33 - Bos taurus (Bovine) - USP33 gene Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Indicus|evm.model.CM009493.1.770 Q8IYH5 ZZZ3_HUMAN 94.020 0.997788 1.00111 ZZZ3 - ZZ-type zinc finger-containing protein 3 - Homo sapiens (Human) - ZZZ3 gene Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Indicus|evm.model.CM009493.1.771 A4IFD0 KAD5_BOVIN 99.374 0.995833 0.854093 Ak5 - Adenylate kinase isoenzyme 5 - Bos taurus (Bovine) - Ak5 gene Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. Indicus|evm.model.CM009493.1.772 Q3MHZ7 GPI8_BOVIN 90.380 0.994429 0.908861 PIGK - GPI-anchor transamidase precursor - Bos taurus (Bovine) - PIGK gene Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). Indicus|evm.model.CM009493.1.773 Q9BVH7 SIA7E_HUMAN 81.526 0.890756 0.708333 ST6GALNAC5 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 - Homo sapiens (Human) - ST6GALNAC5 gene Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transfering the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1 Indicus|evm.model.CM009493.1.774 Q9BVH7 SIA7E_HUMAN 71.569 0.912621 0.306548 ST6GALNAC5 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 - Homo sapiens (Human) - ST6GALNAC5 gene Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transfering the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1 Indicus|evm.model.CM009493.1.775 Q8NDV1 SIA7C_HUMAN 98.551 0.971429 0.229508 ST6GALNAC3 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 - Homo sapiens (Human) - ST6GALNAC3 gene Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:16169874, PubMed:17123352). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (PubMed:17123352). Indicus|evm.model.CM009493.1.776 Q8NDV1 SIA7C_HUMAN 97.537 0.782946 0.845902 ST6GALNAC3 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 - Homo sapiens (Human) - ST6GALNAC3 gene Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:16169874, PubMed:17123352). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (PubMed:17123352). Indicus|evm.model.CM009493.1.777 Q32KY8 ASB17_BOVIN 100.000 0.993243 1.00339 ASB17 - Ankyrin repeat and SOCS box protein 17 - Bos taurus (Bovine) - ASB17 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009493.1.778 O15457 MSH4_HUMAN 92.325 0.940541 0.988248 MSH4 - MutS protein homolog 4 - Homo sapiens (Human) - MSH4 gene Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Indicus|evm.model.CM009493.1.779 Q5E9B3 PGTB2_BOVIN 100.000 0.993976 1.00302 RABGGTB - Geranylgeranyl transferase type-2 subunit beta - Bos taurus (Bovine) - RABGGTB gene Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Indicus|evm.model.CM009493.1.780 Q3SZB4 ACADM_BOVIN 100.000 0.995261 1.00238 ACADM - Medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACADM gene Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains. Indicus|evm.model.CM009493.1.782 Q95JW2 CTL5_MACFA 75.592 0.997046 0.944212 SLC44A5 - Choline transporter-like protein 5 - Macaca fascicularis (Crab-eating macaque) - SLC44A5 gene Indicus|evm.model.CM009493.1.783 Q68G74 LHX8_HUMAN 97.458 0.625 1.05618 LHX8 - LIM/homeobox protein Lhx8 - Homo sapiens (Human) - LHX8 gene Transcription factor involved in differentiation of certain neurons and mesenchymal cells. Indicus|evm.model.CM009493.1.784 Q5E9U4 TYW3_BOVIN 99.612 0.992278 1.00388 TYW3 - tRNA wybutosine-synthesizing protein 3 homolog - Bos taurus (Bovine) - TYW3 gene Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). Indicus|evm.model.CM009493.1.785 O97764 QOR_BOVIN 99.697 0.993958 1.00303 CRYZ - Zeta-crystallin - Bos taurus (Bovine) - CRYZ gene Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity). Has minimal or no quinone reductase activity. Binds strongly to single-stranded DNA. Indicus|evm.model.CM009493.1.786 Q5RHP9 ERIC3_HUMAN 83.735 0.435583 0.745752 ERICH3 - Glutamate-rich protein 3 - Homo sapiens (Human) - ERICH3 gene Indicus|evm.model.CM009493.1.788 Q5RF15 TNI3K_PONAB 96.780 0.704545 1.35275 TNNI3K - Serine/threonine-protein kinase TNNI3K - Pongo abelii (Sumatran orangutan) - TNNI3K gene May play a role in cardiac physiology. Indicus|evm.model.CM009493.1.789 O14772 FPGT_HUMAN 85.908 0.978369 0.990115 FPGT - Fucose-1-phosphate guanylyltransferase - Homo sapiens (Human) - FPGT gene Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. Indicus|evm.model.CM009493.1.790 A6PVS8 LRIQ3_HUMAN 87.692 0.984772 0.315705 LRRIQ3 - Leucine-rich repeat and IQ domain-containing protein 3 - Homo sapiens (Human) - LRRIQ3 gene Indicus|evm.model.CM009493.1.791 Q5NVM8 RNPS1_PONAB 78.846 0.421488 0.396721 RNPS1 - RNA-binding protein with serine-rich domain 1 - Pongo abelii (Sumatran orangutan) - RNPS1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity). Indicus|evm.model.CM009493.1.792 A6PVS8 LRIQ3_HUMAN 61.017 0.960784 0.490385 LRRIQ3 - Leucine-rich repeat and IQ domain-containing protein 3 - Homo sapiens (Human) - LRRIQ3 gene Indicus|evm.model.CM009493.1.793 Q3MHR7 ARPC2_BOVIN 73.667 0.929293 0.99 ARPC2 - Actin-related protein 2/3 complex subunit 2 - Bos taurus (Bovine) - ARPC2 gene Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Indicus|evm.model.CM009493.1.794 Q13490 BIRC2_HUMAN 52.923 0.951807 0.402913 BIRC2 - Baculoviral IAP repeat-containing protein 2 - Homo sapiens (Human) - BIRC2 gene Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. Indicus|evm.model.CM009493.1.795 Q4R4Z6 RS3A_MACFA 88.202 0.977273 0.666667 RPS3A - 40S ribosomal protein S3a - Macaca fascicularis (Crab-eating macaque) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009493.1.797 Q5R580 ZRAB2_PONAB 99.676 0.930514 1.03438 ZRANB2 - Zinc finger Ran-binding domain-containing protein 2 - Pongo abelii (Sumatran orangutan) - ZRANB2 gene Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection (By similarity). Indicus|evm.model.CM009493.1.798 P34979 PE2R3_BOVIN 99.721 0.917949 0.935252 PTGER3 - Prostaglandin E2 receptor EP3 subtype - Bos taurus (Bovine) - PTGER3 gene Receptor for prostaglandin E2 (PGE2) (PubMed:8396726). The various isoforms have identical ligand binding properties but interact with different second messenger systems: isoform EP3A couples to G(i)/G(o) proteins; isoform EP3B and isoform EP3C couple to G(s), and isoform EP3D couples to G(i), G(s) and G(p) (PubMed:8396726). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity). Indicus|evm.model.CM009493.1.799 Q58DW2 CGL_BOVIN 99.753 0.946136 1.05432 CTH - Cystathionine gamma-lyase - Bos taurus (Bovine) - CTH gene Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (By similarity). Indicus|evm.model.CM009493.1.800 Q8N6S4 AN13C_HUMAN 76.051 0.995726 0.865065 ANKRD13C - Ankyrin repeat domain-containing protein 13C - Homo sapiens (Human) - ANKRD13C gene Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER. Indicus|evm.model.CM009493.1.801 Q05519 SRS11_HUMAN 98.347 0.995859 0.997934 SRSF11 - Serine/arginine-rich splicing factor 11 - Homo sapiens (Human) - SRSF11 gene May function in pre-mRNA splicing. Indicus|evm.model.CM009493.1.802 Q4R3P6 LRC40_MACFA 92.027 0.996683 1.00166 LRRC40 - Leucine-rich repeat-containing protein 40 - Macaca fascicularis (Crab-eating macaque) - LRRC40 gene Indicus|evm.model.CM009493.1.803 F1MCA7 LRRC7_BOVIN 99.779 0.976208 0.902995 LRRC7 - Leucine-rich repeat-containing protein 7 - Bos taurus (Bovine) - LRRC7 gene Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression (By similarity). Indicus|evm.model.CM009493.1.805 Q5TB30 DEP1A_HUMAN 87.744 0.97954 0.964242 DEPDC1 - DEP domain-containing protein 1A - Homo sapiens (Human) - DEPDC1 gene May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. Indicus|evm.model.CM009493.1.806 A4IFF3 TTC9C_BOVIN 97.661 0.988372 1.00585 TTC9C - Tetratricopeptide repeat protein 9C - Bos taurus (Bovine) - TTC9C gene Indicus|evm.model.CM009493.1.807 Q28175 RPE65_BOVIN 99.812 0.996255 1.00188 RPE65 - Retinoid isomerohydrolase - Bos taurus (Bovine) - RPE65 gene Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16096063, PubMed:19805034, PubMed:20100834). Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (PubMed:15186777). Indicus|evm.model.CM009493.1.810 O95661 DIRA3_HUMAN 56.838 0.991453 1.02183 DIRAS3 - GTP-binding protein Di-Ras3 precursor - Homo sapiens (Human) - DIRAS3 gene plasma membrane, GDP binding, GTP binding, GTPase activity, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of gene expression by genetic imprinting, small GTPase mediated signal transduction Indicus|evm.model.CM009493.1.811 Q3ZBN6 GA45A_BOVIN 100.000 0.987952 1.00606 GADD45A - Growth arrest and DNA damage-inducible protein GADD45 alpha - Bos taurus (Bovine) - GADD45A gene Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Indicus|evm.model.CM009493.1.812 Q8NC51 PAIRB_HUMAN 99.020 0.995098 1 SERBP1 - Plasminogen activator inhibitor 1 RNA-binding protein - Homo sapiens (Human) - SERBP1 gene May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Indicus|evm.model.CM009493.1.813 Q9BEG2 I12R2_BOVIN 100.000 0.99768 1.00116 IL12RB2 - Interleukin-12 receptor subunit beta-2 precursor - Bos taurus (Bovine) - IL12RB2 gene Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. On IL12 stimulation, enhances IFN-gamma expression. Indicus|evm.model.CM009493.1.814 Q5VWK5 IL23R_HUMAN 72.425 0.970486 0.915739 IL23R - Interleukin-23 receptor precursor - Homo sapiens (Human) - IL23R gene Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Indicus|evm.model.CM009493.1.815 Q3SYW6 EIF3C_BOVIN 81.250 0.407895 0.0833333 EIF3C - Eukaryotic translation initiation factor 3 subunit C - Bos taurus (Bovine) - EIF3C gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Indicus|evm.model.CM009493.1.816 Q2KIL1 CA141_BOVIN 99.535 0.99536 1.00233 Uncharacterized protein C1orf141 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009493.1.817 A2VE55 S35D2_BOVIN 99.718 0.994382 1.00282 SLC35D2 - UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter - Bos taurus (Bovine) - SLC35D2 gene Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-GlcNAc, the donor substrate, and thus be involved in growth factor signaling (By similarity). Indicus|evm.model.CM009493.1.818 Q8N108 MIER1_HUMAN 96.071 0.897163 1.10156 MIER1 - Mesoderm induction early response protein 1 - Homo sapiens (Human) - MIER1 gene Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. Indicus|evm.model.CM009493.1.819 Q5VTH9 DNAI4_HUMAN 81.258 0.991432 0.963443 DNAI4 - Dynein axonemal intermediate chain 4 - Homo sapiens (Human) - DNAI4 gene Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility. Indicus|evm.model.CM009493.1.820 Q5CZK5 INSL5_PANTR 68.889 0.985294 1.00741 INSL5 - Insulin-like peptide INSL5 precursor - Pan troglodytes (Chimpanzee) - INSL5 gene May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity). Indicus|evm.model.CM009493.1.821 Q8N7M0 DYLT5_HUMAN 82.584 0.988827 1 DYNLT5 - Dynein light chain Tctex-type 5 - Homo sapiens (Human) - DYNLT5 gene Indicus|evm.model.CM009493.1.822 Q9BQI5 SGIP1_HUMAN 98.592 0.462418 0.73913 SGIP1 - SH3-containing GRB2-like protein 3-interacting protein 1 - Homo sapiens (Human) - SGIP1 gene May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. Indicus|evm.model.CM009493.1.824 Q07343 PDE4B_HUMAN 96.012 0.899171 0.983696 PDE4B - cAMP-specific 3',5'-cyclic phosphodiesterase 4B - Homo sapiens (Human) - PDE4B gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. Indicus|evm.model.CM009493.1.825 O02671 LEPR_PIG 84.464 0.998224 0.966524 LEPR - Leptin receptor precursor - Sus scrofa (Pig) - LEPR gene Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (By similarity). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). Indicus|evm.model.CM009493.1.826 Q3SYT0 OBRG_BOVIN 99.237 0.984848 1.00763 LEPROT - Leptin receptor gene-related protein - Bos taurus (Bovine) - LEPROT gene Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). Indicus|evm.model.CM009493.1.827 Q27974 AUXI_BOVIN 100.000 0.935185 1.06813 DNAJC6 - Putative tyrosine-protein phosphatase auxilin - Bos taurus (Bovine) - DNAJC6 gene Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (PubMed:15502813). Plays a role in clathrin-mediated endocytosis in neurons (By similarity). Indicus|evm.model.CM009493.1.828 Q0VCP1 KAD4_BOVIN 100.000 0.991071 1.00448 AK4 - Adenylate kinase 4, mitochondrial - Bos taurus (Bovine) - AK4 gene Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular response to oxidative stress (By similarity). Indicus|evm.model.CM009493.1.830 P23458 JAK1_HUMAN 97.140 0.99396 1.00433 JAK1 - Tyrosine-protein kinase JAK1 - Homo sapiens (Human) - JAK1 gene Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Indicus|evm.model.CM009493.1.831 Q4KM98 MFF_RAT 66.667 0.372727 0.504587 Mff - Mitochondrial fission factor - Rattus norvegicus (Rat) - Mff gene Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. Indicus|evm.model.CM009493.1.832 Q9HCJ3 RAVR2_HUMAN 90.328 0.866667 0.911722 RAVER2 - Ribonucleoprotein PTB-binding 2 - Homo sapiens (Human) - RAVER2 gene May bind single-stranded nucleic acids. Indicus|evm.model.CM009493.1.833 Q5VU97 CAHD1_HUMAN 96.739 0.998448 1.01177 CACHD1 - VWFA and cache domain-containing protein 1 precursor - Homo sapiens (Human) - CACHD1 gene May regulate voltage-dependent calcium channels. Indicus|evm.model.CM009493.1.834 Q5VVX9 UBE2U_HUMAN 58.696 0.992933 0.88162 UBE2U - Ubiquitin-conjugating enzyme E2 U - Homo sapiens (Human) - UBE2U gene Catalyzes the covalent attachment of ubiquitin to other proteins. Indicus|evm.model.CM009493.1.835 Q01973 ROR1_HUMAN 98.081 0.978982 0.964781 ROR1 - Inactive tyrosine-protein kinase transmembrane receptor ROR1 precursor - Homo sapiens (Human) - ROR1 gene Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Indicus|evm.model.CM009493.1.836 Q08DP0 PGM1_BOVIN 100.000 0.996448 1.00178 PGM1 - Phosphoglucomutase-1 - Bos taurus (Bovine) - PGM1 gene This enzyme participates in both the breakdown and synthesis of glucose. Indicus|evm.model.CM009493.1.837 A8K855 EFCB7_HUMAN 87.917 0.996825 1.00159 EFCAB7 - EF-hand calcium-binding domain-containing protein 7 - Homo sapiens (Human) - EFCAB7 gene Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. Indicus|evm.model.CM009493.1.839 Q63245 FOXD3_RAT 100.000 0.207469 4.77228 Foxd3 - Forkhead box protein D3 - Rattus norvegicus (Rat) - Foxd3 gene Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (By similarity). Indicus|evm.model.CM009493.1.841 Q96DT6 ATG4C_HUMAN 93.886 0.995643 1.00218 ATG4C - Cysteine protease ATG4C - Homo sapiens (Human) - ATG4C gene Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Indicus|evm.model.CM009493.1.842 Q96N67 DOCK7_HUMAN 97.009 0.999047 0.980841 DOCK7 - Dedicator of cytokinesis protein 7 - Homo sapiens (Human) - DOCK7 gene Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). Indicus|evm.model.CM009493.1.843 Q29RP1 UBP1_BOVIN 99.872 0.997449 1.00128 USP1 - Ubiquitin carboxyl-terminal hydrolase 1 - Bos taurus (Bovine) - USP1 gene Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Indicus|evm.model.CM009493.1.844 Q5T7N3 KANK4_HUMAN 78.304 0.895575 1.13568 KANK4 - KN motif and ankyrin repeat domain-containing protein 4 - Homo sapiens (Human) - KANK4 gene May be involved in the control of cytoskeleton formation by regulating actin polymerization. Indicus|evm.model.CM009493.1.845 Q96N20 ZN75A_HUMAN 86.207 0.193103 0.489865 ZNF75A - Zinc finger protein 75A - Homo sapiens (Human) - ZNF75A gene May be involved in transcriptional regulation. Indicus|evm.model.CM009493.1.846 E2QYC9 INADL_CANLF 87.603 0.953354 1.04376 PATJ - InaD-like protein - Canis lupus familiaris (Dog) - PATJ gene Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:17235357). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:15738264). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (PubMed:17235357). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (PubMed:17235357). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (By similarity). Indicus|evm.model.CM009493.1.847 Q9BX74 TM2D1_HUMAN 77.295 0.988701 0.855072 TM2D1 - TM2 domain-containing protein 1 precursor - Homo sapiens (Human) - TM2D1 gene May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42. Indicus|evm.model.CM009493.1.849 P02694 RET1_BOVIN 95.556 0.985294 1.00741 RBP1 - Retinol-binding protein 1 - Bos taurus (Bovine) - RBP1 gene Cytoplasmic retinol-binding protein (PubMed:7744071). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis. Indicus|evm.model.CM009493.1.850 Q12857 NFIA_HUMAN 99.213 0.933702 1.0668 NFIA - Nuclear factor 1 A-type - Homo sapiens (Human) - NFIA gene Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Indicus|evm.model.CM009493.1.852 Q58DW0 RL4_BOVIN 88.060 0.826087 0.381517 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Indicus|evm.model.CM009493.1.853 Q58DW0 RL4_BOVIN 88.889 0.938095 0.49763 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Indicus|evm.model.CM009493.1.854 Q8N0U7 CA087_HUMAN 74.672 0.996255 0.978022 C1orf87 - Uncharacterized protein C1orf87 - Homo sapiens (Human) - C1orf87 gene Indicus|evm.model.CM009493.1.855 P51589 CP2J2_HUMAN 79.482 0.996024 1.00199 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Indicus|evm.model.CM009493.1.856 P52786 CP2J1_RABIT 53.804 0.938202 0.355289 CYP2J1 - Cytochrome P450 2J1 - Oryctolagus cuniculus (Rabbit) - CYP2J1 gene Catalyzes the N-demethylation of benzphetamine to formaldehyde. Indicus|evm.model.CM009493.1.857 P51589 CP2J2_HUMAN 74.251 0.994036 1.00199 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Indicus|evm.model.CM009493.1.858 P51589 CP2J2_HUMAN 76.295 0.996024 1.00199 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Indicus|evm.model.CM009493.1.859 P52786 CP2J1_RABIT 65.455 0.865079 0.251497 CYP2J1 - Cytochrome P450 2J1 - Oryctolagus cuniculus (Rabbit) - CYP2J1 gene Catalyzes the N-demethylation of benzphetamine to formaldehyde. Indicus|evm.model.CM009493.1.860 P51589 CP2J2_HUMAN 76.471 0.827869 0.243028 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Indicus|evm.model.CM009493.1.861 P51589 CP2J2_HUMAN 85.714 0.986301 0.436255 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Indicus|evm.model.CM009493.1.862 P51589 CP2J2_HUMAN 75.050 0.994036 1.00199 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Indicus|evm.model.CM009493.1.863 Q9UJC3 HOOK1_HUMAN 95.879 0.997257 1.00137 HOOK1 - Protein Hook homolog 1 - Homo sapiens (Human) - HOOK1 gene Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Indicus|evm.model.CM009493.1.864 Q9XSG3 IDHC_BOVIN 94.313 0.929204 0.545894 IDH1 - Isocitrate dehydrogenase [NADP] cytoplasmic - Bos taurus (Bovine) - IDH1 gene May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. Indicus|evm.model.CM009493.1.865 Q96C11 FGGY_HUMAN 92.015 0.99637 1 FGGY - FGGY carbohydrate kinase domain-containing protein - Homo sapiens (Human) - FGGY gene D-ribulokinase activity, carbohydrate phosphorylation, neuron cellular homeostasis, pentose metabolic process Indicus|evm.model.CM009493.1.866 O77627 JUN_BOVIN 100.000 0.994048 1.00299 JUN - Transcription factor AP-1 - Bos taurus (Bovine) - JUN gene Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter. Indicus|evm.model.CM009493.1.867 Q5VVJ2 MYSM1_HUMAN 86.826 0.997596 1.00483 MYSM1 - Deubiquitinase MYSM1 - Homo sapiens (Human) - MYSM1 gene Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). Indicus|evm.model.CM009493.1.868 P09758 TACD2_HUMAN 80.667 0.934375 0.990712 TACSTD2 - Tumor-associated calcium signal transducer 2 precursor - Homo sapiens (Human) - TACSTD2 gene May function as a growth factor receptor. Indicus|evm.model.CM009493.1.869 Q3SZN3 OMA1_BOVIN 100.000 0.996183 1.00191 OMA1 - Metalloendopeptidase OMA1, mitochondrial precursor - Bos taurus (Bovine) - OMA1 gene Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion (By similarity). Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae. In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome. May also cleave UQCC3 in response to mitochondrial depolarization. Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (By similarity). Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Binds cardiolipin, possibly regulating its protein turnover. Required for the stability of the respiratory supercomplexes (By similarity). Indicus|evm.model.CM009493.1.871 P62755 RS6_RAT 71.341 0.964497 0.678715 Rps6 - 40S ribosomal protein S6 - Rattus norvegicus (Rat) - Rps6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009493.1.872 Q9BGX5 DAB1_MACFA 97.137 0.937276 1.00541 DAB1 - Disabled homolog 1 - Macaca fascicularis (Crab-eating macaque) - DAB1 gene Adapter molecule functioning in neural development. May regulate SIAH1 activity. Indicus|evm.model.CM009493.1.873 P07358 CO8B_HUMAN 82.881 0.996616 1 C8B - Complement component C8 beta chain precursor - Homo sapiens (Human) - C8B gene Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Indicus|evm.model.CM009493.1.874 P07357 CO8A_HUMAN 76.231 0.99661 1.01027 C8A - Complement component C8 alpha chain precursor - Homo sapiens (Human) - C8A gene Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. Indicus|evm.model.CM009493.1.875 Q5VWT5 FYB2_HUMAN 58.832 0.791183 1.18407 FYB2 - FYN-binding protein 2 - Homo sapiens (Human) - FYB2 gene Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation (PubMed:27335501). Indicus|evm.model.CM009493.1.876 P54646 AAPK2_HUMAN 98.043 0.995662 0.835145 PRKAA2 - 5'-AMP-activated protein kinase catalytic subunit alpha-2 - Homo sapiens (Human) - PRKAA2 gene Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. In that process also activates WDR45 (PubMed:28561066). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1. Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation. Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Indicus|evm.model.CM009493.1.877 Q3SZE3 PLPP3_BOVIN 100.000 0.99359 1.00322 PLPP3 - Phospholipid phosphatase 3 - Bos taurus (Bovine) - PLPP3 gene Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (By similarity). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (By similarity). Indicus|evm.model.CM009493.1.878 Q9P265 DIP2B_HUMAN 92.000 0.98 0.0317259 DIP2B - Disco-interacting protein 2 homolog B - Homo sapiens (Human) - DIP2B gene Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. Indicus|evm.model.CM009493.1.881 Q2HJ93 PHF11_BOVIN 82.456 0.811594 0.204748 PHF11 - PHD finger protein 11 - Bos taurus (Bovine) - PHF11 gene Positive regulator of Th1-type cytokine gene expression. Indicus|evm.model.CM009493.1.882 Q9UPU5 UBP24_HUMAN 97.402 0.986811 0.954962 USP24 - Ubiquitin carboxyl-terminal hydrolase 24 - Homo sapiens (Human) - USP24 gene Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. Indicus|evm.model.CM009493.1.884 Q8WZ55 BSND_HUMAN 73.913 0.99375 1 BSND - Barttin - Homo sapiens (Human) - BSND gene Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. Indicus|evm.model.CM009493.1.885 Q8N0U2 TMM61_HUMAN 68.571 0.990521 1.00476 TMEM61 - Transmembrane protein 61 - Homo sapiens (Human) - TMEM61 gene Indicus|evm.model.CM009493.1.887 Q15392 DHC24_HUMAN 96.899 0.996132 1.00194 DHCR24 - Delta(24)-sterol reductase precursor - Homo sapiens (Human) - DHCR24 gene Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:25637936, PubMed:22178193). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892). Indicus|evm.model.CM009493.1.888 Q3ZCV2 LEXM_HUMAN 78.191 0.991935 0.889952 LEXM - Lymphocyte expansion molecule - Homo sapiens (Human) - LEXM gene Indicus|evm.model.CM009493.1.889 Q7L3T8 SYPM_HUMAN 86.947 0.470705 2.12 PARS2 - Probable proline--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - PARS2 gene mitochondrion, proline-tRNA ligase activity, prolyl-tRNA aminoacylation Indicus|evm.model.CM009493.1.890 Q5EA11 TTC4_BOVIN 99.227 0.974811 1.0232 TTC4 - Tetratricopeptide repeat protein 4 - Bos taurus (Bovine) - TTC4 gene May act as a co-chaperone for HSP90AB1 (By similarity). Indicus|evm.model.CM009493.1.891 Q68CQ1 MROH7_HUMAN 76.165 0.998481 0.995465 MROH7 - Maestro heat-like repeat-containing protein family member 7 - Homo sapiens (Human) - MROH7 gene extracellular space Indicus|evm.model.CM009493.1.892 Q5RDY9 F151A_PONAB 78.205 0.92845 1.00342 FAM151A - Protein FAM151A - Pongo abelii (Sumatran orangutan) - FAM151A gene Indicus|evm.model.CM009493.1.893 Q8WXI4 ACO11_HUMAN 88.525 0.530973 0.186161 ACOT11 - Acyl-coenzyme A thioesterase 11 precursor - Homo sapiens (Human) - ACOT11 gene Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway. Indicus|evm.model.CM009493.1.894 Q5RDY9 F151A_PONAB 77.839 0.930034 1.00171 FAM151A - Protein FAM151A - Pongo abelii (Sumatran orangutan) - FAM151A gene Indicus|evm.model.CM009493.1.895 Q8WXI4 ACO11_HUMAN 92.125 0.915825 0.978583 ACOT11 - Acyl-coenzyme A thioesterase 11 precursor - Homo sapiens (Human) - ACOT11 gene Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway. Indicus|evm.model.CM009493.1.896 Q9R050 SSBP3_RAT 99.169 0.994475 1.00277 Ssbp3 - Single-stranded DNA-binding protein 3 - Rattus norvegicus (Rat) - Ssbp3 gene May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. Indicus|evm.model.CM009493.1.897 A4FUC0 RM37_BOVIN 100.000 0.995283 1.00236 MRPL37 - 39S ribosomal protein L37, mitochondrial precursor - Bos taurus (Bovine) - MRPL37 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion Indicus|evm.model.CM009493.1.898 Q6IPT4 NB5R5_HUMAN 84.768 0.955556 1 CYB5RL - NADH-cytochrome b5 reductase-like - Homo sapiens (Human) - CYB5RL gene NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Indicus|evm.model.CM009493.1.900 Q5VXM1 CDCP2_HUMAN 91.292 0.629433 1.25612 CDCP2 - CUB domain-containing protein 2 precursor - Homo sapiens (Human) - CDCP2 gene Indicus|evm.model.CM009493.1.902 A5PKE4 TEAN2_BOVIN 100.000 0.990431 1.00481 TCEANC2 - Transcription elongation factor A N-terminal and central domain-containing protein 2 - Bos taurus (Bovine) - TCEANC2 gene Indicus|evm.model.CM009493.1.903 Q3T0Q2 TMM59_BOVIN 99.074 0.993846 1.00619 TMEM59 - Transmembrane protein 59 precursor - Bos taurus (Bovine) - TMEM59 gene Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. Indicus|evm.model.CM009493.1.904 Q5T700 LRAD1_HUMAN 79.126 0.990338 1.00976 LDLRAD1 - Low-density lipoprotein receptor class A domain-containing protein 1 - Homo sapiens (Human) - LDLRAD1 gene Indicus|evm.model.CM009493.1.905 Q2HJ90 LRC42_BOVIN 99.766 0.829126 1.20327 LRRC42 - Leucine-rich repeat-containing protein 42 - Bos taurus (Bovine) - LRRC42 gene Indicus|evm.model.CM009493.1.906 Q9Y547 IFT25_HUMAN 90.210 0.986111 1 HSPB11 - Intraflagellar transport protein 25 homolog - Homo sapiens (Human) - HSPB11 gene Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity). Indicus|evm.model.CM009493.1.907 Q6QN13 IOD1_PIG 67.686 0.878049 0.823293 DIO1 - Type I iodothyronine deiodinase - Sus scrofa (Pig) - DIO1 gene Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Indicus|evm.model.CM009493.1.908 Q9Y548 YIPF1_HUMAN 92.500 0.97546 0.53268 YIPF1 - Protein YIPF1 - Homo sapiens (Human) - YIPF1 gene Golgi apparatus, Golgi medial cisterna, Golgi trans cisterna, nucleoplasm, plasma membrane, trans-Golgi network, transport vesicle Indicus|evm.model.CM009493.1.909 Q5RBL0 YIPF1_PONAB 91.892 0.864706 0.555556 YIPF1 - Protein YIPF1 - Pongo abelii (Sumatran orangutan) - YIPF1 gene Golgi medial cisterna, Golgi trans cisterna, trans-Golgi network Indicus|evm.model.CM009493.1.910 Q9BTX1 NDC1_HUMAN 90.963 0.866324 1.1543 NDC1 - Nucleoporin NDC1 - Homo sapiens (Human) - NDC1 gene Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. Indicus|evm.model.CM009493.1.911 Q8K1M4 GLIS1_MOUSE 71.277 0.584416 0.195184 Glis1 - Zinc finger protein GLIS1 - Mus musculus (Mouse) - Glis1 gene Acts as both a repressor and activator of transcription (PubMed:12042312, PubMed:12385751, PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (PubMed:12042312). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807, PubMed:30544251). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (PubMed:30544251). Indicus|evm.model.CM009493.1.912 Q8NBF1 GLIS1_HUMAN 89.516 0.865734 1.15323 GLIS1 - Zinc finger protein GLIS1 - Homo sapiens (Human) - GLIS1 gene Acts as both a repressor and activator of transcription (PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (By similarity). Indicus|evm.model.CM009493.1.913 Q96MA1 DMRTB_HUMAN 60.734 0.910811 1.08187 DMRTB1 - Doublesex- and mab-3-related transcription factor B1 - Homo sapiens (Human) - DMRTB1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, germ cell development, regulation of transcription by RNA polymerase II, sex differentiation Indicus|evm.model.CM009493.1.914 Q5R7W2 MPCP_PONAB 82.993 0.885196 0.916898 SLC25A3 - Phosphate carrier protein, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - SLC25A3 gene Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) (By similarity). Indicus|evm.model.CM009493.1.915 Q924X6 LRP8_MOUSE 76.203 0.936658 0.74498 Lrp8 - Low-density lipoprotein receptor-related protein 8 precursor - Mus musculus (Mouse) - Lrp8 gene Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation (PubMed:12695510). May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (PubMed:18174160). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (PubMed:29336888). Indicus|evm.model.CM009493.1.916 Q27W02 MGN_RAT 100.000 0.986395 1.00685 Magoh - Protein mago nashi homolog - Rattus norvegicus (Rat) - Magoh gene Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Indicus|evm.model.CM009493.1.917 Q32P66 CZIB_BOVIN 99.375 0.987578 1.00625 CZIB - CXXC motif containing zinc binding protein - Bos taurus (Bovine) - CZIB gene zinc ion binding Indicus|evm.model.CM009493.1.918 Q2KJB7 CPT2_BOVIN 99.088 0.996965 1.00152 CPT2 - Carnitine O-palmitoyltransferase 2, mitochondrial precursor - Bos taurus (Bovine) - CPT2 gene Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters. Indicus|evm.model.CM009493.1.919 O00341 EAA5_HUMAN 89.761 0.973378 1.07321 SLC1A7 - Excitatory amino acid transporter 5 - Homo sapiens (Human) - SLC1A7 gene Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing. Indicus|evm.model.CM009493.1.920 Q7Z5L7 PODN_HUMAN 94.425 0.936275 0.998369 PODN - Podocan precursor - Homo sapiens (Human) - PODN gene Negatively regulates cell proliferation and cell migration. Indicus|evm.model.CM009493.1.921 A1XQU9 RS20_PIG 72.973 0.36 0.840336 RPS20 - 40S ribosomal protein S20 - Sus scrofa (Pig) - RPS20 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, small ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009493.1.922 P07857 SCP2_BOVIN 87.293 0.995918 0.902394 SCP2 - Sterol carrier protein 2 - Bos taurus (Bovine) - SCP2 gene Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (By similarity). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). Indicus|evm.model.CM009493.1.923 Q2TBT3 ECHD2_BOVIN 100.000 0.993266 1.00338 ECHDC2 - Enoyl-CoA hydratase domain-containing protein 2, mitochondrial precursor - Bos taurus (Bovine) - ECHDC2 gene mitochondrion, enoyl-CoA hydratase activity, fatty acid beta-oxidation Indicus|evm.model.CM009493.1.924 Q6WRX3 ZY11A_HUMAN 84.656 0.997358 0.997365 ZYG11A - Protein zyg-11 homolog A - Homo sapiens (Human) - ZYG11A gene Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC. Indicus|evm.model.CM009493.1.925 Q9C0D3 ZY11B_HUMAN 99.059 0.997315 1.00134 ZYG11B - Protein zyg-11 homolog B - Homo sapiens (Human) - ZYG11B gene Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation (PubMed:33093214). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098). Indicus|evm.model.CM009493.1.926 Q921H9 COA7_MOUSE 73.160 0.989189 0.800866 Coa7 - Cytochrome c oxidase assembly factor 7 - Mus musculus (Mouse) - Coa7 gene Required for assembly of mitochondrial respiratory chain complex I and complex IV. Indicus|evm.model.CM009493.1.927 Q6UWV7 SHL2A_HUMAN 78.421 0.989418 0.994737 SHISAL2A - Protein shisa-like-2A - Homo sapiens (Human) - SHISAL2A gene Indicus|evm.model.CM009493.1.928 A6QLY2 GPX7_BOVIN 100.000 0.989305 1.00538 GPX7 - Glutathione peroxidase 7 precursor - Bos taurus (Bovine) - GPX7 gene endoplasmic reticulum, peroxidase activity Indicus|evm.model.CM009493.1.929 Q5TAX3 TUT4_HUMAN 89.448 0.998796 1.01034 TUT4 - Terminal uridylyltransferase 4 - Homo sapiens (Human) - TUT4 gene Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:16643855, PubMed:19703396, PubMed:18172165) (By similarity). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). Indicus|evm.model.CM009493.1.930 Q5RDD2 PR38A_PONAB 100.000 0.99361 1.00321 PRPF38A - Pre-mRNA-splicing factor 38A - Pongo abelii (Sumatran orangutan) - PRPF38A gene Involved in pre-mRNA splicing as a component of the spliceosome. Indicus|evm.model.CM009493.1.931 Q58DC8 ORC1_BOVIN 99.768 0.997685 1.00116 ORC1 - Origin recognition complex subunit 1 - Bos taurus (Bovine) - ORC1 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Indicus|evm.model.CM009493.1.932 Q5T0F9 C2D1B_HUMAN 85.482 0.997664 0.997669 CC2D1B - Coiled-coil and C2 domain-containing protein 1B - Homo sapiens (Human) - CC2D1B gene Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. Indicus|evm.model.CM009493.1.933 O95405 ZFYV9_HUMAN 90.175 0.998594 0.997895 ZFYVE9 - Zinc finger FYVE domain-containing protein 9 - Homo sapiens (Human) - ZFYVE9 gene Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. Indicus|evm.model.CM009493.1.935 Q2KIY7 BT3L4_BOVIN 100.000 0.550877 1.8038 BTF3L4 - Transcription factor BTF3 homolog 4 - Bos taurus (Bovine) - BTF3L4 gene Indicus|evm.model.CM009493.1.936 Q5E936 TXD12_BOVIN 100.000 0.988439 1.00581 TXNDC12 - Thioredoxin domain-containing protein 12 precursor - Bos taurus (Bovine) - TXNDC12 gene Possesses significant protein thiol-disulfide oxidase activity. Indicus|evm.model.CM009493.1.937 P10948 RAB3B_BOVIN 100.000 0.990909 1.00457 RAB3B - Ras-related protein Rab-3B - Bos taurus (Bovine) - RAB3B gene Protein transport. Probably involved in vesicular traffic (By similarity). Indicus|evm.model.CM009493.1.938 O43847 NRDC_HUMAN 95.886 0.813574 1.01129 NRDC - Nardilysin precursor - Homo sapiens (Human) - NRDC gene Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Indicus|evm.model.CM009493.1.939 Q96SU4 OSBL9_HUMAN 94.022 0.997268 0.994565 OSBPL9 - Oxysterol-binding protein-related protein 9 - Homo sapiens (Human) - OSBPL9 gene cytosol, Golgi apparatus, intracellular membrane-bounded organelle, membrane, sterol binding, sterol transporter activity, bile acid biosynthetic process Indicus|evm.model.CM009493.1.940 P28491 CALR_PIG 51.042 0.621777 0.83693 CALR - Calreticulin precursor - Sus scrofa (Pig) - CALR gene Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (PubMed:20222029). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). Indicus|evm.model.CM009493.1.942 A2ACP1 TT39A_MOUSE 93.606 0.965636 1.00692 Ttc39a - Tetratricopeptide repeat protein 39A - Mus musculus (Mouse) - Ttc39a gene centrosome Indicus|evm.model.CM009493.1.943 Q2M2T8 CA185_BOVIN 93.750 0.862348 1.0786 Uncharacterized protein C1orf185 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009493.1.945 P42773 CDN2C_HUMAN 94.048 0.988166 1.00595 CDKN2C - Cyclin-dependent kinase 4 inhibitor C - Homo sapiens (Human) - CDKN2C gene Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Indicus|evm.model.CM009493.1.947 A6QQ94 DMTA2_BOVIN 88.224 0.996269 1.00187 DMRTA2 - Doublesex- and mab-3-related transcription factor A2 - Bos taurus (Bovine) - DMRTA2 gene May be involved in sexual development. Indicus|evm.model.CM009493.1.948 O09032 ELAV4_RAT 99.474 0.994751 0.98961 Elavl4 - ELAV-like protein 4 - Rattus norvegicus (Rat) - Elavl4 gene RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10982410, PubMed:16508003, PubMed:17577668). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10982410, PubMed:16508003, PubMed:17577668). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10982410). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (By similarity). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (By similarity). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:10982410, PubMed:17577668). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (By similarity). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (PubMed:16508003). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (By similarity). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:10982410, PubMed:17234598). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (PubMed:10982410). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (PubMed:25692578). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (By similarity). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released form ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (By similarity). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich sequences of CALCA pre-mRNA (By similarity). Indicus|evm.model.CM009493.1.949 Q5VU57 CBPC6_HUMAN 95.745 0.989362 0.186879 AGBL4 - Cytosolic carboxypeptidase 6 - Homo sapiens (Human) - AGBL4 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Indicus|evm.model.CM009493.1.951 Q2KJG1 SPAT6_BOVIN 93.238 0.995652 0.944559 SPATA6 - Spermatogenesis-associated protein 6 precursor - Bos taurus (Bovine) - SPATA6 gene Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits. Indicus|evm.model.CM009493.1.952 Q2M3M2 SC5A9_HUMAN 87.959 0.997067 1.00147 SLC5A9 - Sodium/glucose cotransporter 4 - Homo sapiens (Human) - SLC5A9 gene Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose. Indicus|evm.model.CM009493.1.953 A0A0E4BZH1 SKIT1_MACFA 70.796 0.591228 1.61017 SKINT1 - Selection and upkeep of intraepithelial T-cells protein 1 - Macaca fascicularis (Crab-eating macaque) - SKINT1 gene May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus. Indicus|evm.model.CM009493.1.954 B1ATG9 TIKI2_MOUSE 97.758 0.977974 0.439072 Trabd2b - Metalloprotease TIKI2 precursor - Mus musculus (Mouse) - Trabd2b gene Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation (By similarity). Indicus|evm.model.CM009493.1.956 A6NFA1 TIKI2_HUMAN 83.444 0.986885 0.589942 TRABD2B - Metalloprotease TIKI2 precursor - Homo sapiens (Human) - TRABD2B gene Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. Indicus|evm.model.CM009493.1.957 Q63251 FOXD1_RAT 100.000 0.265252 3.73267 Foxd1 - Forkhead box protein D1 - Rattus norvegicus (Rat) - Foxd1 gene Transcription factor involved in regulation of gene expression in a variety of processes including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes (By similarity). Indicus|evm.model.CM009493.1.958 Q2KIW9 KCY_BOVIN 100.000 0.851528 1.16837 CMPK1 - UMP-CMP kinase - Bos taurus (Bovine) - CMPK1 gene Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. Indicus|evm.model.CM009493.1.959 Q15468 STIL_HUMAN 77.205 0.991681 0.933955 STIL - SCL-interrupting locus protein - Homo sapiens (Human) - STIL gene Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). Indicus|evm.model.CM009493.1.960 P17542 TAL1_HUMAN 97.802 0.874396 0.625378 TAL1 - T-cell acute lymphocytic leukemia protein 1 - Homo sapiens (Human) - TAL1 gene Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). Indicus|evm.model.CM009493.1.961 Q2KIP5 PDZ1I_BOVIN 99.123 0.982609 1.00877 PDZK1IP1 - PDZK1-interacting protein 1 - Bos taurus (Bovine) - PDZK1IP1 gene Indicus|evm.model.CM009493.1.962 Q8N118 CP4X1_HUMAN 60.079 0.972103 0.915521 CYP4X1 - Cytochrome P450 4X1 - Homo sapiens (Human) - CYP4X1 gene A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.CM009493.1.963 P14580 CP4A6_RABIT 79.570 0.782609 0.22549 CYP4A6 - Cytochrome P450 4A6 precursor - Oryctolagus cuniculus (Rabbit) - CYP4A6 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Indicus|evm.model.CM009493.1.964 P14579 CP4A5_RABIT 70.000 0.654971 0.334638 CYP4A5 - Cytochrome P450 4A5 precursor - Oryctolagus cuniculus (Rabbit) - CYP4A5 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Indicus|evm.model.CM009493.1.965 Q8SPK1 CP4AO_PIG 79.359 0.96699 1.02183 CYP4A24 - Cytochrome P450 4A24 - Sus scrofa (Pig) - CYP4A24 gene Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Has no activity toward taurochenodeoxycholic acid. Indicus|evm.model.CM009493.1.966 Q8SPK1 CP4AO_PIG 70.474 0.972414 0.863095 CYP4A24 - Cytochrome P450 4A24 - Sus scrofa (Pig) - CYP4A24 gene Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Has no activity toward taurochenodeoxycholic acid. Indicus|evm.model.CM009493.1.968 Q9GJX5 CP4AL_PIG 79.158 0.957692 1.03175 CYP4A21 - Taurochenodeoxycholic 6 alpha-hydroxylase - Sus scrofa (Pig) - CYP4A21 gene Catalyzes the 6 alpha hydroxylation oxidation of taurodeoxycholate to produce the pig specific bile acid taurohyocholic acid. Indicus|evm.model.CM009493.1.969 P15128 CP4B1_RABIT 83.665 0.978516 1.01186 CYP4B1 - Cytochrome P450 4B1 - Oryctolagus cuniculus (Rabbit) - CYP4B1 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Indicus|evm.model.CM009493.1.970 O75071 EFC14_HUMAN 86.667 0.99596 1 EFCAB14 - EF-hand calcium-binding domain-containing protein 14 - Homo sapiens (Human) - EFCAB14 gene Indicus|evm.model.CM009493.1.971 Q6PEX7 TEX38_HUMAN 73.953 0.990741 1.04854 TEX38 - Testis-expressed protein 38 - Homo sapiens (Human) - TEX38 gene Indicus|evm.model.CM009493.1.972 Q5TC12 ATPF1_HUMAN 93.590 0.879656 1.06402 ATPAF1 - ATP synthase mitochondrial F1 complex assembly factor 1 precursor - Homo sapiens (Human) - ATPAF1 gene May play an essential role for the assembly of the mitochondrial F1-F0 complex. Indicus|evm.model.CM009493.1.973 Q5EAA4 MOB3C_BOVIN 100.000 0.990783 1.00463 MOB3C - MOB kinase activator 3C - Bos taurus (Bovine) - MOB3C gene May regulate the activity of kinases. Indicus|evm.model.CM009493.1.974 Q58D94 MKNK1_BOVIN 99.286 0.995249 1.00238 MKNK1 - MAP kinase-interacting serine/threonine-protein kinase 1 - Bos taurus (Bovine) - MKNK1 gene May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity). Indicus|evm.model.CM009493.1.975 A6PVL3 KNCN_HUMAN 89.431 0.976 1.00806 KNCN - Kinocilin - Homo sapiens (Human) - KNCN gene May play a role in stabilizing dense microtubular networks or in vesicular trafficking. Indicus|evm.model.CM009493.1.976 A0A0U1RQS6 TM275_HUMAN 74.157 0.988764 1.00565 TMEM275 - Transmembrane protein 275 - Homo sapiens (Human) - TMEM275 gene Indicus|evm.model.CM009493.1.977 Q8NFW5 DMBX1_HUMAN 92.932 0.994667 0.981675 DMBX1 - Diencephalon/mesencephalon homeobox protein 1 - Homo sapiens (Human) - DMBX1 gene Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity). Indicus|evm.model.CM009493.1.978 Q90578 VDHAP_CHICK 54.306 0.711604 1.26293 Vitamin D3 hydroxylase-associated protein - Gallus gallus (Chicken) Indicus|evm.model.CM009493.1.979 O00519 FAAH1_HUMAN 85.492 0.996552 1.00173 FAAH - Fatty-acid amide hydrolase 1 - Homo sapiens (Human) - FAAH gene Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity). Indicus|evm.model.CM009493.1.981 Q0V8R7 NSUN4_BOVIN 100.000 0.994805 1.0026 NSUN4 - 5-methylcytosine rRNA methyltransferase NSUN4 precursor - Bos taurus (Bovine) - NSUN4 gene Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4 (By similarity). Indicus|evm.model.CM009493.1.982 P00126 QCR6_BOVIN 100.000 0.978261 1.01099 UQCRH - Cytochrome b-c1 complex subunit 6, mitochondrial precursor - Bos taurus (Bovine) - UQCRH gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Indicus|evm.model.CM009493.1.983 Q8K1C9 LRC41_MOUSE 100.000 0.967213 0.151177 Lrrc41 - Leucine-rich repeat-containing protein 41 - Mus musculus (Mouse) - Lrrc41 gene Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009493.1.984 Q29RR1 LRC41_BOVIN 99.154 0.918288 0.63145 LRRC41 - Leucine-rich repeat-containing protein 41 - Bos taurus (Bovine) - LRRC41 gene cytoplasm, nucleus Indicus|evm.model.CM009493.1.985 Q29RR1 LRC41_BOVIN 100.000 0.990909 0.27027 LRRC41 - Leucine-rich repeat-containing protein 41 - Bos taurus (Bovine) - LRRC41 gene cytoplasm, nucleus Indicus|evm.model.CM009493.1.986 P70270 RAD54_MOUSE 94.786 0.996 1.00402 Rad54l - DNA repair and recombination protein RAD54-like - Mus musculus (Mouse) - Rad54l gene Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Plays also an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). Deficiency also resulted in an increased frequency of end-to-end chromosome fusions involving telomeres compared to the controls, suggesting a putative role in telomere capping. Non-homologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. LIG4 and RAD54L cooperate to support cellular proliferation, repair spontaneous DSBs, and prevent chromosome and single chromatid aberrations (PubMed:10209103, PubMed:10757799, PubMed:12218123, PubMed:12531026, PubMed:12548566, PubMed:12897131, PubMed:15175260, PubMed:9108475). Indicus|evm.model.CM009493.1.987 Q96LR2 LURA1_HUMAN 90.795 0.991667 1.00418 LURAP1 - Leucine rich adaptor protein 1 - Homo sapiens (Human) - LURAP1 gene Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). Indicus|evm.model.CM009493.1.988 Q5EAB6 PMGT1_BOVIN 99.848 0.816605 1.22273 POMGNT1 - Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 - Bos taurus (Bovine) - POMGNT1 gene Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose. Indicus|evm.model.CM009493.1.989 Q3T0S3 TSN1_BOVIN 98.340 0.991736 1.00415 TSPAN1 - Tetraspanin-1 - Bos taurus (Bovine) - TSPAN1 gene integral component of plasma membrane Indicus|evm.model.CM009493.1.990 B1AUF7 P3URF_MOUSE 70.526 0.979167 1.06667 P3r3urf - PIK3R3 upstream open reading frame protein - Mus musculus (Mouse) - P3r3urf gene phosphatidylinositol 3-kinase complex, 1-phosphatidylinositol-3-kinase regulator activity, phosphatidylinositol phosphorylation Indicus|evm.model.CM009493.1.991 O46404 P55G_BOVIN 99.520 0.995215 0.906725 PIK3R3 - Phosphatidylinositol 3-kinase regulatory subunit gamma - Bos taurus (Bovine) - PIK3R3 gene Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Indicus|evm.model.CM009493.1.992 Q6P0Q8 MAST2_HUMAN 89.630 0.986142 1.00334 MAST2 - Microtubule-associated serine/threonine-protein kinase 2 - Homo sapiens (Human) - MAST2 gene Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). Indicus|evm.model.CM009493.1.993 Q9Y573 IPP_HUMAN 95.719 0.996581 1.00171 IPP - Actin-binding protein IPP - Homo sapiens (Human) - IPP gene May play a role in organizing the actin cytoskeleton. Indicus|evm.model.CM009493.1.994 Q5R9C3 GPBL1_PONAB 94.093 0.435143 2.29325 GPBP1L1 - Vasculin-like protein 1 - Pongo abelii (Sumatran orangutan) - GPBP1L1 gene Possible transcription factor. Indicus|evm.model.CM009493.1.995 Q2T9P4 NASP_BOVIN 99.871 0.708676 1.40927 NASP - Nuclear autoantigenic sperm protein - Bos taurus (Bovine) - NASP gene Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. Indicus|evm.model.CM009493.1.996 P24049 RL17_RAT 93.506 0.987097 0.842391 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009493.1.997 Q5E947 PRDX1_BOVIN 100.000 0.99 1.00503 PRDX1 - Peroxiredoxin-1 - Bos taurus (Bovine) - PRDX1 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). Indicus|evm.model.CM009493.1.998 Q5E9C8 MMAC_BOVIN 100.000 0.992883 1.00357 MMACHC - Cyanocobalamin reductase / alkylcobalamin dealkylase - Bos taurus (Bovine) - MMACHC gene Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle. Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether. The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors. Cysteine and homocysteine cannot substitute for glutathione in this reaction. Indicus|evm.model.CM009493.1.999 A0A0D9SF12 CC163_HUMAN 77.778 0.104167 2.31724 CCDC163 - Transmembrane protein CCDC163 - Homo sapiens (Human) - CCDC163 gene Indicus|evm.model.CM009493.1.1000 Q96S53 TESK2_HUMAN 91.449 0.996516 1.00525 TESK2 - Dual specificity testis-specific protein kinase 2 - Homo sapiens (Human) - TESK2 gene Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. Indicus|evm.model.CM009493.1.1001 Q17QN2 TOE1_BOVIN 100.000 0.99619 1.00191 TOE1 - Target of EGR1 protein 1 - Bos taurus (Bovine) - TOE1 gene Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing. Indicus|evm.model.CM009493.1.1002 Q9UIF7 MUTYH_HUMAN 79.702 0.996205 0.965201 MUTYH - Adenine DNA glycosylase - Homo sapiens (Human) - MUTYH gene Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. Indicus|evm.model.CM009493.1.1003 Q96IR7 HPDL_HUMAN 84.906 0.946292 1.05391 HPDL - 4-hydroxyphenylpyruvate dioxygenase-like protein - Homo sapiens (Human) - HPDL gene May have dioxygenase activity. Indicus|evm.model.CM009493.1.1004 Q9P217 ZSWM5_HUMAN 97.475 0.991976 0.84135 ZSWIM5 - Zinc finger SWIM domain-containing protein 5 - Homo sapiens (Human) - ZSWIM5 gene Cul2-RING ubiquitin ligase complex, extracellular space, regulation of axon guidance Indicus|evm.model.CM009493.1.1005 Q8HY31 DCUP_SHEEP 99.455 0.994565 1.00272 UROD - Uroporphyrinogen decarboxylase - Ovis aries (Sheep) - UROD gene Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. Indicus|evm.model.CM009493.1.1006 Q5T447 HECD3_HUMAN 98.606 0.99768 1.00116 HECTD3 - E3 ubiquitin-protein ligase HECTD3 - Homo sapiens (Human) - HECTD3 gene E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). Indicus|evm.model.CM009493.1.1007 A5PJI7 EI2BG_BOVIN 99.270 0.944444 0.318584 EIF2B3 - Translation initiation factor eIF-2B subunit gamma - Bos taurus (Bovine) - EIF2B3 gene Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Indicus|evm.model.CM009493.1.1008 P20821 GCSH_BOVIN 85.549 0.9875 0.924855 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Indicus|evm.model.CM009493.1.1009 A5PJI7 EI2BG_BOVIN 100.000 0.674419 0.856195 EIF2B3 - Translation initiation factor eIF-2B subunit gamma - Bos taurus (Bovine) - EIF2B3 gene Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Indicus|evm.model.CM009493.1.1010 Q9Y6C5 PTC2_HUMAN 93.621 0.998344 1.00416 PTCH2 - Protein patched homolog 2 - Homo sapiens (Human) - PTCH2 gene Plays a role in the control of cellular growth (PubMed:18285427). May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH). Indicus|evm.model.CM009493.1.1011 A6QPA3 BTBDJ_BOVIN 100.000 0.993151 1.00344 BTBD19 - BTB/POZ domain-containing protein 19 - Bos taurus (Bovine) - BTBD19 gene Indicus|evm.model.CM009493.1.1012 Q4VYA0 DYLT4_PIG 75.342 0.990909 1.00457 DYNLT4 - Dynein light chain Tctex-type 4 - Sus scrofa (Pig) - DYNLT4 gene acrosomal vesicle, axoneme, cytoplasm, microtubule organizing center, nucleus, sperm flagellum, protein phosphatase 1 binding Indicus|evm.model.CM009493.1.1013 Q9H4B4 PLK3_HUMAN 92.369 0.969136 1.0031 PLK3 - Serine/threonine-protein kinase PLK3 - Homo sapiens (Human) - PLK3 gene Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. Indicus|evm.model.CM009493.1.1014 Q8NFU0 BEST4_HUMAN 90.698 0.995726 0.989429 BEST4 - Bestrophin-4 - Homo sapiens (Human) - BEST4 gene Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Indicus|evm.model.CM009493.1.1015 P62243 RS8_RAT 100.000 0.990431 1.00481 Rps8 - 40S ribosomal protein S8 - Rattus norvegicus (Rat) - Rps8 gene cytosolic small ribosomal subunit, ribonucleoprotein complex, structural constituent of ribosome, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009493.1.1016 Q95LP1 KIF2C_MACFA 91.493 0.924033 1.07899 KIF2C - Kinesin-like protein KIF2C - Macaca fascicularis (Crab-eating macaque) - KIF2C gene In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment. Indicus|evm.model.CM009493.1.1017 A7MBF6 ARMD1_BOVIN 98.152 0.794118 1.23077 ARMH1 - Armadillo-like helical domain containing protein 1 - Bos taurus (Bovine) - ARMH1 gene Indicus|evm.model.CM009493.1.1018 Q2TBP5 TMM53_BOVIN 100.000 0.99322 1.0034 TMEM53 - Transmembrane protein 53 - Bos taurus (Bovine) - TMEM53 gene Indicus|evm.model.CM009493.1.1019 Q08DV5 RN220_BOVIN 99.823 0.996473 1.00177 RNF220 - E3 ubiquitin-protein ligase RNF220 - Bos taurus (Bovine) - RNF220 gene E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (By similarity). Indicus|evm.model.CM009493.1.1020 A6QLH5 ERI3_BOVIN 100.000 0.992308 0.771513 ERI3 - ERI1 exoribonuclease 3 - Bos taurus (Bovine) - ERI3 gene 3'-5'-exoribonuclease activity, DNA catabolic process, exonucleolytic, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009493.1.1021 Q9NPF5 DMAP1_HUMAN 98.504 0.995736 1.00428 DMAP1 - DNA methyltransferase 1-associated protein 1 - Homo sapiens (Human) - DMAP1 gene Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. Indicus|evm.model.CM009493.1.1022 P57054 PIGP_HUMAN 81.818 0.697248 0.689873 PIGP - Phosphatidylinositol N-acetylglucosaminyltransferase subunit P - Homo sapiens (Human) - PIGP gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Indicus|evm.model.CM009493.1.1023 Q8CFA7 KLF17_MOUSE 60.920 0.232432 1.08504 Klf17 - Krueppel-like factor 17 - Mus musculus (Mouse) - Klf17 gene Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development. Indicus|evm.model.CM009493.1.1024 Q5JT82 KLF17_HUMAN 63.953 0.159475 1.37018 KLF17 - Krueppel-like factor 17 - Homo sapiens (Human) - KLF17 gene Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity). Indicus|evm.model.CM009493.1.1025 C7EMF5 KLF17_PIG 71.538 0.974937 1.03101 KLF17 - Krueppel-like factor 17 - Sus scrofa (Pig) - KLF17 gene Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity). Indicus|evm.model.CM009493.1.1026 Q28039 SC6A9_BOVIN 98.876 0.981073 0.99373 SLC6A9 - Sodium- and chloride-dependent glycine transporter 1 - Bos taurus (Bovine) - SLC6A9 gene Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission (By similarity). Indicus|evm.model.CM009493.1.1027 Q8N4L8 CCD24_HUMAN 75.649 0.980769 1.01629 CCDC24 - Coiled-coil domain-containing protein 24 - Homo sapiens (Human) - CCDC24 gene Indicus|evm.model.CM009493.1.1028 O60909 B4GT2_HUMAN 95.161 0.994595 0.994624 B4GALT2 - Beta-1,4-galactosyltransferase 2 - Homo sapiens (Human) - B4GALT2 gene Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids (PubMed:9405390). Can produce lactose (PubMed:9405390). Indicus|evm.model.CM009493.1.1029 Q2TA24 VATO_BOVIN 100.000 0.990291 1.00488 ATP6V0B - V-type proton ATPase 21 kDa proteolipid subunit - Bos taurus (Bovine) - ATP6V0B gene Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). Indicus|evm.model.CM009493.1.1030 Q08DM2 DPH2_BOVIN 99.796 0.995918 1.00204 DPH2 - 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 - Bos taurus (Bovine) - DPH2 gene Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). Indicus|evm.model.CM009493.1.1031 A7YWD2 IPO13_BOVIN 100.000 0.997925 1.00104 IPO13 - Importin-13 - Bos taurus (Bovine) - IPO13 gene Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 (By similarity). Indicus|evm.model.CM009493.1.1032 Q5T4W7 ARTN_HUMAN 94.203 0.790698 0.390909 ARTN - Artemin precursor - Homo sapiens (Human) - ARTN gene Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Indicus|evm.model.CM009493.1.1033 P61132 SIAT6_PANTR 98.540 0.954545 0.762667 ST3GAL3 - CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Pan troglodytes (Chimpanzee) - ST3GAL3 gene Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. Indicus|evm.model.CM009493.1.1034 P61132 SIAT6_PANTR 95.714 0.447368 0.405333 ST3GAL3 - CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Pan troglodytes (Chimpanzee) - ST3GAL3 gene Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. Indicus|evm.model.CM009493.1.1035 Q5RD88 KDM4A_PONAB 95.314 0.998126 1.00282 KDM4A - Lysine-specific demethylase 4A - Pongo abelii (Sumatran orangutan) - KDM4A gene Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (By similarity). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (By similarity). Indicus|evm.model.CM009493.1.1036 A7MBJ4 PTPRF_BOVIN 99.476 0.998952 1.00527 PTPRF - Receptor-type tyrosine-protein phosphatase F precursor - Bos taurus (Bovine) - PTPRF gene Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity). Indicus|evm.model.CM009493.1.1037 Q5T013 HYI_HUMAN 79.422 0.99262 0.978339 HYI - Putative hydroxypyruvate isomerase - Homo sapiens (Human) - HYI gene Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). Indicus|evm.model.CM009493.1.1038 Q5T011 SZT2_HUMAN 92.834 0.999417 0.999417 SZT2 - KICSTOR complex protein SZT2 - Homo sapiens (Human) - SZT2 gene As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). Indicus|evm.model.CM009493.1.1039 Q9D7W5 MED8_MOUSE 97.388 0.988889 1.00746 Med8 - Mediator of RNA polymerase II transcription subunit 8 - Mus musculus (Mouse) - Med8 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Indicus|evm.model.CM009493.1.1040 Q9BW60 ELOV1_HUMAN 92.115 0.88254 1.12903 ELOVL1 - Elongation of very long chain fatty acids protein 1 - Homo sapiens (Human) - ELOVL1 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905). Indirectly inhibits RPE65 via production of VLCFAs. Indicus|evm.model.CM009493.1.1041 Q5H7C0 CDC20_PIG 98.397 0.996 1.002 CDC20 - Cell division cycle protein 20 homolog - Sus scrofa (Pig) - CDC20 gene Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). Indicus|evm.model.CM009493.1.1042 P40931 MPL_MPLV 82.162 0.285271 3.50543 V-MPL - Myeloproliferative leukemia protein - Myeloproliferative leukemia virus (MpLV) - V-MPL gene Truncated form of the receptor for thrombopoietin. Indicus|evm.model.CM009493.1.1043 Q06805 TIE1_BOVIN 99.561 0.998246 1.00352 TIE1 - Tyrosine-protein kinase receptor Tie-1 precursor - Bos taurus (Bovine) - TIE1 gene Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Indicus|evm.model.CM009493.1.1044 Q45FY6 HPRT_PIG 94.495 0.990868 1.00459 HPRT1 - Hypoxanthine-guanine phosphoribosyltransferase - Sus scrofa (Pig) - HPRT1 gene Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). Indicus|evm.model.CM009493.1.1045 Q8IVY1 CA210_HUMAN 72.566 0.982456 1.00885 C1orf210 - Type III endosome membrane protein TEMP - Homo sapiens (Human) - C1orf210 gene May be involved in membrane trafficking between endosomes and plasma membrane. Indicus|evm.model.CM009493.1.1046 Q2HJ59 TM125_BOVIN 99.543 0.990909 1.00457 TMEM125 - Transmembrane protein 125 - Bos taurus (Bovine) - TMEM125 gene Indicus|evm.model.CM009493.1.1047 Q96MR6 CFA57_HUMAN 94.886 0.801843 0.1736 CFAP57 - Cilia- and flagella-associated protein 57 - Homo sapiens (Human) - CFAP57 gene Indicus|evm.model.CM009493.1.1048 Q5E9Z8 LSM1_BOVIN 92.308 0.0824176 8.21053 LSM1 - U6 snRNA-associated Sm-like protein LSm1 - Bos taurus (Bovine) - LSM1 gene Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). Indicus|evm.model.CM009493.1.1049 Q99848 EBP2_HUMAN 90.196 0.993464 1 EBNA1BP2 - Probable rRNA-processing protein EBP2 - Homo sapiens (Human) - EBNA1BP2 gene Required for the processing of the 27S pre-rRNA. Indicus|evm.model.CM009493.1.1050 A8QW39 F183A_BOVIN 100.000 0.985294 1.00741 FAM183A - Protein FAM183A - Bos taurus (Bovine) - FAM183A gene ciliary base Indicus|evm.model.CM009493.1.1052 B5U6Y8 OXLA_ECHOC 50.403 0.964706 1.0119 L-amino-acid oxidase precursor - Echis ocellatus (Ocellated saw-scaled viper) Indicus|evm.model.CM009493.1.1053 Q99880 H2B1L_HUMAN 88.000 0.843537 1.16667 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009493.1.1054 P27674 GTR1_BOVIN 100.000 0.995943 1.00203 SLC2A1 - Solute carrier family 2, facilitated glucose transporter member 1 - Bos taurus (Bovine) - SLC2A1 gene Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Indicus|evm.model.CM009493.1.1055 Q17QR7 ZN691_BOVIN 99.645 0.992933 1.00355 ZNF691 - Zinc finger protein 691 - Bos taurus (Bovine) - ZNF691 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009493.1.1056 Q96PL5 ERMAP_HUMAN 83.051 0.830508 0.745263 ERMAP - Erythroid membrane-associated protein precursor - Homo sapiens (Human) - ERMAP gene Possible role as a cell-adhesion or receptor molecule of erythroid cells. Indicus|evm.model.CM009493.1.1057 Q32LJ0 SVBP_BOVIN 100.000 0.970149 1.01515 SVBP - Small vasohibin-binding protein - Bos taurus (Bovine) - SVBP gene Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation (By similarity). Indicus|evm.model.CM009493.1.1058 A0A1B0GVZ9 TM269_HUMAN 76.211 0.904 1.02041 TMEM269 - Transmembrane protein 269 - Homo sapiens (Human) - TMEM269 gene Indicus|evm.model.CM009493.1.1059 Q9BV19 CA050_HUMAN 86.294 0.956098 1.03015 C1orf50 - Uncharacterized protein C1orf50 - Homo sapiens (Human) - C1orf50 gene identical protein binding Indicus|evm.model.CM009493.1.1060 Q32P28 P3H1_HUMAN 91.304 0.997286 1.00136 P3H1 - Prolyl 3-hydroxylase 1 precursor - Homo sapiens (Human) - P3H1 gene Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. Indicus|evm.model.CM009493.1.1061 Q8N6F1 CLD19_HUMAN 95.735 0.990566 0.946429 CLDN19 - Claudin-19 - Homo sapiens (Human) - CLDN19 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009493.1.1062 Q9D868 PPIH_MOUSE 100.000 0.213001 3.84574 Ppih - Peptidyl-prolyl cis-trans isomerase H - Mus musculus (Mouse) - Ppih gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. Indicus|evm.model.CM009493.1.1063 Q5VVM6 CCD30_HUMAN 69.066 0.692964 1.19796 CCDC30 - Coiled-coil domain-containing protein 30 - Homo sapiens (Human) - CCDC30 gene Indicus|evm.model.CM009493.1.1064 Q9HAB8 PPCS_HUMAN 89.389 0.99359 1.00322 PPCS - Phosphopantothenate--cysteine ligase - Homo sapiens (Human) - PPCS gene Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11923312, PubMed:12906824, PubMed:29754768). Has a preference for ATP over CTP as a cosubstrate (PubMed:11923312). Indicus|evm.model.CM009493.1.1065 Q9H0C1 ZMY12_HUMAN 86.066 0.99455 1.00548 ZMYND12 - Zinc finger MYND domain-containing protein 12 - Homo sapiens (Human) - ZMYND12 gene Indicus|evm.model.CM009493.1.1066 Q8IXN7 RIMKA_HUMAN 96.675 0.994898 1.00256 RIMKLA - N-acetylaspartylglutamate synthase A - Homo sapiens (Human) - RIMKLA gene Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate. Indicus|evm.model.CM009493.1.1067 Q9UPW0 FOXJ3_HUMAN 91.520 0.996622 0.951768 FOXJ3 - Forkhead box protein J3 - Homo sapiens (Human) - FOXJ3 gene Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity). Indicus|evm.model.CM009493.1.1068 P79897 GUC2A_PIG 72.321 0.982301 1.0367 GUCA2A - Guanylin precursor - Sus scrofa (Pig) - GUCA2A gene Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. Indicus|evm.model.CM009493.1.1069 O13009 GUC2B_PIG 80.531 0.982456 1.00885 GUCA2B - Guanylate cyclase activator 2B precursor - Sus scrofa (Pig) - GUCA2B gene Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity). Indicus|evm.model.CM009493.1.1071 Q5T1R4 ZEP3_HUMAN 87.770 0.997911 0.994597 HIVEP3 - Transcription factor HIVEP3 - Homo sapiens (Human) - HIVEP3 gene Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. Indicus|evm.model.CM009493.1.1072 Q867A9 EDN2_BOVIN 98.870 0.988764 1.00565 EDN2 - Endothelin-2 precursor - Bos taurus (Bovine) - EDN2 gene Endothelins are endothelium-derived vasoconstrictor peptides. Indicus|evm.model.CM009493.1.1074 A8MYZ6 FOXO6_HUMAN 68.103 0.583756 0.400407 FOXO6 - Forkhead box protein O6 - Homo sapiens (Human) - FOXO6 gene Transcriptional activator. Indicus|evm.model.CM009493.1.1075 A8MYZ6 FOXO6_HUMAN 97.101 0.925676 0.300813 FOXO6 - Forkhead box protein O6 - Homo sapiens (Human) - FOXO6 gene Transcriptional activator. Indicus|evm.model.CM009493.1.1077 Q96GD3 SCMH1_HUMAN 91.888 0.944615 0.984848 SCMH1 - Polycomb protein SCMH1 - Homo sapiens (Human) - SCMH1 gene Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. Indicus|evm.model.CM009493.1.1079 Q8BHW9 SLNL1_MOUSE 68.957 0.984252 0.929268 Slfnl1 - Schlafen-like protein 1 - Mus musculus (Mouse) - Slfnl1 gene Indicus|evm.model.CM009493.1.1080 P70698 PYRG1_MOUSE 98.477 0.996622 1.00169 Ctps1 - CTP synthase 1 - Mus musculus (Mouse) - Ctps1 gene This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. Indicus|evm.model.CM009493.1.1081 Q9HCK0 ZBT26_HUMAN 90.930 0.995283 0.961451 ZBTB26 - Zinc finger and BTB domain-containing protein 26 - Homo sapiens (Human) - ZBTB26 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009493.1.1082 Q2HJ78 CITE4_BOVIN 100.000 0.989247 1.00541 CITED4 - Cbp/p300-interacting transactivator 4 - Bos taurus (Bovine) - CITED4 gene Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells (By similarity). Indicus|evm.model.CM009493.1.1083 Q9JK97 KCNQ4_MOUSE 97.288 0.94847 0.892241 Kcnq4 - Potassium voltage-gated channel subfamily KQT member 4 - Mus musculus (Mouse) - Kcnq4 gene Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. Indicus|evm.model.CM009493.1.1084 Q5E9X1 NFYC_BOVIN 100.000 0.994048 1.00299 NFYC - Nuclear transcription factor Y subunit gamma - Bos taurus (Bovine) - NFYC gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors (By similarity). Indicus|evm.model.CM009493.1.1085 Q9UJD0 RIMS3_HUMAN 96.104 0.993528 1.00325 RIMS3 - Regulating synaptic membrane exocytosis protein 3 - Homo sapiens (Human) - RIMS3 gene Regulates synaptic membrane exocytosis. Indicus|evm.model.CM009493.1.1086 P13984 T2FB_HUMAN 69.620 0.914729 1.03614 GTF2F2 - General transcription factor IIF subunit 2 - Homo sapiens (Human) - GTF2F2 gene TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. Indicus|evm.model.CM009493.1.1087 Q4R6J4 ZN684_MACFA 81.627 0.992167 1.01323 ZNF684 - Zinc finger protein 684 - Macaca fascicularis (Crab-eating macaque) - ZNF684 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009493.1.1088 A2VDX7 EXO5_BOVIN 100.000 0.994609 1.0027 EXO5 - Exonuclease V - Bos taurus (Bovine) - EXO5 gene Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity (By similarity). Indicus|evm.model.CM009493.1.1089 A7MBI1 ZFP69_BOVIN 99.618 0.99619 1.00191 ZFP69 - Zinc finger protein 69 homolog - Bos taurus (Bovine) - ZFP69 gene Putative transcription factor that appears to regulate lipid metabolism. Indicus|evm.model.CM009493.1.1090 Q9UJL9 ZF69B_HUMAN 82.842 0.994638 0.698502 ZFP69B - Zinc finger protein 69 homolog B - Homo sapiens (Human) - ZFP69B gene May be involved in transcriptional regulation. Essential for Golgi structural integrity (PubMed:29851555). Indicus|evm.model.CM009493.1.1092 P61515 RL37P_RAT 66.197 0.811765 0.923913 Rpl37a-ps1 - Putative 60S ribosomal protein L37a - Rattus norvegicus (Rat) - Rpl37a-ps1 gene Indicus|evm.model.CM009493.1.1093 Q5EA00 SMAP2_BOVIN 100.000 0.995349 1.00233 SMAP2 - Stromal membrane-associated protein 2 - Bos taurus (Bovine) - SMAP2 gene GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). Indicus|evm.model.CM009493.1.1094 C0HLN2 CO9A2_BOVIN 94.331 0.996928 0.946221 COL9A2 - Collagen alpha-2(IX) chain precursor - Bos taurus (Bovine) - COL9A2 gene Structural component of hyaline cartilage and vitreous of the eye. Indicus|evm.model.CM009493.1.1095 O75844 FACE1_HUMAN 96.835 0.993697 1.00211 ZMPSTE24 - CAAX prenyl protease 1 homolog - Homo sapiens (Human) - ZMPSTE24 gene Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. Indicus|evm.model.CM009493.1.1096 P84100 RL19_RAT 81.818 0.394161 0.69898 Rpl19 - 60S ribosomal protein L19 - Rattus norvegicus (Rat) - Rpl19 gene cytosolic large ribosomal subunit, polysomal ribosome, synapse, 5.8S rRNA binding, large ribosomal subunit rRNA binding, RNA binding, structural constituent of ribosome, cytoplasmic translation, liver regeneration Indicus|evm.model.CM009493.1.1097 Q2NKV5 TMCO2_BOVIN 100.000 0.989071 1.00549 TMCO2 - Transmembrane and coiled-coil domain-containing protein 2 - Bos taurus (Bovine) - TMCO2 gene Indicus|evm.model.CM009493.1.1098 Q13129 RLF_HUMAN 94.130 0.985886 0.999478 RLF - Zinc finger protein Rlf - Homo sapiens (Human) - RLF gene May be involved in transcriptional regulation. Indicus|evm.model.CM009493.1.1099 P45478 PPT1_BOVIN 100.000 0.993485 1.00327 PPT1 - Palmitoyl-protein thioesterase 1 precursor - Bos taurus (Bovine) - PPT1 gene Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. Indicus|evm.model.CM009493.1.1100 Q3SYV4 CAP1_BOVIN 99.788 0.995763 1 CAP1 - Adenylyl cyclase-associated protein 1 - Bos taurus (Bovine) - CAP1 gene Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. Indicus|evm.model.CM009493.1.1101 Q9DA75 NLS1_MOUSE 87.828 0.99619 0.983146 Mfsd2a - Sodium-dependent lysophosphatidylcholine symporter 1 - Mus musculus (Mouse) - Mfsd2a gene Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:24828044, PubMed:24828040). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid (PubMed:24828044). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis (PubMed:24828040). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. Indicus|evm.model.CM009493.1.1102 P12524 MYCL_HUMAN 90.934 0.918987 1.08516 MYCL - Protein L-Myc - Homo sapiens (Human) - MYCL gene chromatin, chromosome, nucleoplasm, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009493.1.1103 Q9H3H1 MOD5_HUMAN 88.842 0.995798 1.01927 TRIT1 - tRNA dimethylallyltransferase precursor - Homo sapiens (Human) - TRIT1 gene Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). Indicus|evm.model.CM009493.1.1104 P34820 BMP8B_HUMAN 88.396 0.979866 0.741294 BMP8B - Bone morphogenetic protein 8B precursor - Homo sapiens (Human) - BMP8B gene Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Indicus|evm.model.CM009493.1.1105 A4FV72 PPIE_BOVIN 99.668 0.993377 1.00332 PPIE - Peptidyl-prolyl cis-trans isomerase E - Bos taurus (Bovine) - PPIE gene Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity. Indicus|evm.model.CM009493.1.1106 Q5R6S5 HPCL4_PONAB 100.000 0.766129 1.29843 HPCAL4 - Hippocalcin-like protein 4 - Pongo abelii (Sumatran orangutan) - HPCAL4 gene May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Indicus|evm.model.CM009493.1.1107 Q9BXI3 5NT1A_HUMAN 94.565 0.994536 0.994565 NT5C1A - Cytosolic 5'-nucleotidase 1A - Homo sapiens (Human) - NT5C1A gene Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia. Indicus|evm.model.CM009493.1.1108 Q2NL18 HEYL_BOVIN 99.390 0.993921 1.00305 HEYL - Hairy/enhancer-of-split related with YRPW motif-like protein - Bos taurus (Bovine) - HEYL gene Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Indicus|evm.model.CM009493.1.1109 Q13310 PABP4_HUMAN 96.472 0.870321 1.16149 PABPC4 - Polyadenylate-binding protein 4 - Homo sapiens (Human) - PABPC4 gene Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). Indicus|evm.model.CM009493.1.1110 P34820 BMP8B_HUMAN 88.764 0.863415 0.50995 BMP8B - Bone morphogenetic protein 8B precursor - Homo sapiens (Human) - BMP8B gene Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Indicus|evm.model.CM009493.1.1111 Q9BYC2 SCOT2_HUMAN 80.194 0.992278 1.00193 OXCT2 - Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial precursor - Homo sapiens (Human) - OXCT2 gene Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Indicus|evm.model.CM009493.1.1113 P34820 BMP8B_HUMAN 81.988 0.829016 0.4801 BMP8B - Bone morphogenetic protein 8B precursor - Homo sapiens (Human) - BMP8B gene Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Indicus|evm.model.CM009493.1.1115 D3ZHV2 MACF1_RAT 93.065 0.204536 1.3884 Macf1 - Microtubule-actin cross-linking factor 1 - Rattus norvegicus (Rat) - Macf1 gene F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (By similarity). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (By similarity). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). Indicus|evm.model.CM009493.1.1116 Q02379 NDUS5_BOVIN 100.000 0.981308 1.00943 NDUFS5 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 - Bos taurus (Bovine) - NDUFS5 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009493.1.1117 Q9H9L7 AKIR1_HUMAN 95.312 0.989637 1.00521 AKIRIN1 - Akirin-1 - Homo sapiens (Human) - AKIRIN1 gene Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis. May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway. Indicus|evm.model.CM009493.1.1118 A2AGA4 RHBL2_MOUSE 85.149 0.993421 1.00662 Rhbdl2 - Rhomboid-related protein 2 - Mus musculus (Mouse) - Rhbdl2 gene Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity). Indicus|evm.model.CM009493.1.1119 P57773 CXA9_HUMAN 79.264 0.996109 0.998058 GJA9 - Gap junction alpha-9 protein - Homo sapiens (Human) - GJA9 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009493.1.1120 Q2TBP7 MYCBP_BOVIN 100.000 0.80315 1.23301 MYCBP - c-Myc-binding protein - Bos taurus (Bovine) - MYCBP gene May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC (By similarity). Indicus|evm.model.CM009493.1.1121 Q99K70 RRAGC_MOUSE 99.700 0.994012 0.839196 Rragc - Ras-related GTP-binding protein C - Mus musculus (Mouse) - Rragc gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Indicus|evm.model.CM009493.1.1123 Q4QQQ7 PO3F1_XENTR 93.567 0.48433 0.936 pou3f1 - POU domain, class 3, transcription factor 1 - Xenopus tropicalis (Western clawed frog) - pou3f1 gene Acts as a transcription factor (By similarity). May play a role in neuronal differentiation (By similarity). Indicus|evm.model.CM009493.1.1124 Q9Y3A2 UTP11_HUMAN 94.862 0.992126 1.00395 UTP11 - Probable U3 small nucleolar RNA-associated protein 11 - Homo sapiens (Human) - UTP11 gene Involved in nucleolar processing of pre-18S ribosomal RNA. Indicus|evm.model.CM009493.1.1125 Q3ZBI6 FHL3_BOVIN 100.000 0.992883 1.00357 FHL3 - Four and a half LIM domains protein 3 - Bos taurus (Bovine) - FHL3 gene Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. Indicus|evm.model.CM009493.1.1126 Q12874 SF3A3_HUMAN 99.601 0.996016 1.002 SF3A3 - Splicing factor 3A subunit 3 - Homo sapiens (Human) - SF3A3 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:8022796, PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). Indicus|evm.model.CM009493.1.1127 P32019 I5P2_HUMAN 90.327 0.806897 0.876133 INPP5B - Type II inositol 1,4,5-trisphosphate 5-phosphatase precursor - Homo sapiens (Human) - INPP5B gene Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. Indicus|evm.model.CM009493.1.1128 Q14872 MTF1_HUMAN 91.235 0.99734 0.998672 MTF1 - Metal regulatory transcription factor 1 - Homo sapiens (Human) - MTF1 gene Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity). Indicus|evm.model.CM009493.1.1129 Q6ZSJ8 CA122_HUMAN 96.364 0.981982 1.00909 C1orf122 - Uncharacterized protein C1orf122 - Homo sapiens (Human) - C1orf122 gene Indicus|evm.model.CM009493.1.1130 Q0VC80 YRDC_BOVIN 99.638 0.99278 1.00362 YRDC - YrdC domain-containing protein, mitochondrial precursor - Bos taurus (Bovine) - YRDC gene May regulate the activity of some transporters. Indicus|evm.model.CM009493.1.1131 Q5VSG8 MANEL_HUMAN 99.088 0.993939 0.722101 MANEAL - Glycoprotein endo-alpha-1,2-mannosidase-like protein - Homo sapiens (Human) - MANEAL gene Golgi apparatus, alpha-mannosidase activity Indicus|evm.model.CM009493.1.1132 Q5JZY3 EPHAA_HUMAN 96.439 0.320611 1.03968 EPHA10 - Ephrin type-A receptor 10 precursor - Homo sapiens (Human) - EPHA10 gene Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. Indicus|evm.model.CM009493.1.1133 Q5RBS5 BOREA_PONAB 87.189 0.992883 1.00357 Indicus|evm.model.CM009493.1.1134 Q9NX04 CA109_HUMAN 82.547 0.99061 1.04926 C1orf109 - Uncharacterized protein C1orf109 - Homo sapiens (Human) - C1orf109 gene May promote cancer cell proliferation by controlling the G1 to S phase transition. Indicus|evm.model.CM009493.1.1135 Q2MKA7 RSPO1_HUMAN 88.973 0.992395 1 RSPO1 - R-spondin-1 precursor - Homo sapiens (Human) - RSPO1 gene Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805). Indicus|evm.model.CM009493.1.1136 Q13823 NOG2_HUMAN 87.602 0.997271 1.00274 GNL2 - Nucleolar GTP-binding protein 2 - Homo sapiens (Human) - GNL2 gene GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). Indicus|evm.model.CM009493.1.1137 O14645 IDLC_HUMAN 98.062 0.992278 1.00388 DNALI1 - Axonemal dynein light intermediate polypeptide 1 - Homo sapiens (Human) - DNALI1 gene May play a dynamic role in flagellar motility. Indicus|evm.model.CM009493.1.1138 Q8TAD8 SNIP1_HUMAN 87.469 0.995 1.0101 SNIP1 - Smad nuclear-interacting protein 1 - Homo sapiens (Human) - SNIP1 gene Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Indicus|evm.model.CM009493.1.1139 Q58CU0 EAF6_BOVIN 100.000 0.989583 1.00524 MEAF6 - Chromatin modification-related protein MEAF6 - Bos taurus (Bovine) - MEAF6 gene Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Indicus|evm.model.CM009493.1.1140 A6QQJ8 ZC12A_BOVIN 99.485 0.996575 1.00172 ZC3H12A - Ribonuclease ZC3H12A - Bos taurus (Bovine) - ZC3H12A gene Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA. Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (By similarity). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity). Affects the overall ubiquitination of cellular proteins. Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (By similarity). Prevents stress granules (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation. Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state. May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (By similarity). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (By similarity). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (By similarity). Indicus|evm.model.CM009493.1.1143 Q38PU2 GRIK3_MACFA 99.193 0.997696 0.944505 GRIK3 - Glutamate receptor ionotropic, kainate 3 precursor - Macaca fascicularis (Crab-eating macaque) - GRIK3 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity). Indicus|evm.model.CM009493.1.1145 Q99062 CSF3R_HUMAN 73.722 0.997622 1.00598 CSF3R - Granulocyte colony-stimulating factor receptor precursor - Homo sapiens (Human) - CSF3R gene Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. Indicus|evm.model.CM009493.1.1146 P82913 RT15_BOVIN 98.456 0.992308 1.01562 MRPS15 - 28S ribosomal protein S15, mitochondrial precursor - Bos taurus (Bovine) - MRPS15 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009493.1.1147 Q29S00 OSCP1_BOVIN 99.472 0.841871 1.1847 OSCP1 - Protein OSCP1 - Bos taurus (Bovine) - OSCP1 gene May be involved in drug clearance in the placenta. Indicus|evm.model.CM009493.1.1148 Q8QZX5 LSM10_MOUSE 90.833 0.96748 1.0082 Lsm10 - U7 snRNA-associated Sm-like protein LSm10 - Mus musculus (Mouse) - Lsm10 gene Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (By similarity). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to U7 snRNA (By similarity). Binds specifically to U7 snRNA (By similarity). Binds to the downstream cleavage product (DCP) of histone pre-mRNA. Indicus|evm.model.CM009493.1.1149 Q17QV9 STK40_BOVIN 100.000 0.995423 1.00229 STK40 - Serine/threonine-protein kinase 40 - Bos taurus (Bovine) - STK40 gene May be a negative regulator of NF-kappa-B and p53-mediated gene transcription. Indicus|evm.model.CM009493.1.1150 Q9NVM1 EVA1B_HUMAN 91.781 0.819209 1.07273 EVA1B - Protein eva-1 homolog B - Homo sapiens (Human) - EVA1B gene Indicus|evm.model.CM009493.1.1151 Q4R729 SH321_MACFA 56.327 0.57874 1.10116 SH3D21 - SH3 domain-containing protein 21 - Macaca fascicularis (Crab-eating macaque) - SH3D21 gene Indicus|evm.model.CM009493.1.1152 Q9Y2W1 TR150_HUMAN 96.663 0.997912 1.00314 THRAP3 - Thyroid hormone receptor-associated protein 3 - Homo sapiens (Human) - THRAP3 gene Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). Indicus|evm.model.CM009493.1.1154 Q3KQU3 MA7D1_HUMAN 89.972 0.45145 0.942925 MAP7D1 - MAP7 domain-containing protein 1 - Homo sapiens (Human) - MAP7D1 gene cytosol, microtubule cytoskeleton, microtubule cytoskeleton organization Indicus|evm.model.CM009493.1.1155 O43617 TPPC3_HUMAN 99.444 0.98895 1.00556 TRAPPC3 - Trafficking protein particle complex subunit 3 - Homo sapiens (Human) - TRAPPC3 gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Indicus|evm.model.CM009493.1.1156 P25067 CO8A2_HUMAN 95.168 0.967376 1.00284 COL8A2 - Collagen alpha-2(VIII) chain precursor - Homo sapiens (Human) - COL8A2 gene Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). Indicus|evm.model.CM009493.1.1157 Q3SYV9 ADPRS_BOVIN 99.726 0.994536 1.00274 ADPRS - ADP-ribose glycohydrolase ARH3 - Bos taurus (Bovine) - ADPRS gene ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers. Indicus|evm.model.CM009493.1.1158 Q2T9Q6 TEKT2_BOVIN 99.767 0.99536 1.00233 TEKT2 - Tektin-2 - Bos taurus (Bovine) - TEKT2 gene Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Indicus|evm.model.CM009493.1.1160 Q9H9G7 AGO3_HUMAN 99.884 0.997677 1.00116 AGO3 - Protein argonaute-3 - Homo sapiens (Human) - AGO3 gene Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713). Indicus|evm.model.CM009493.1.1161 Q8CJG1 AGO1_MOUSE 99.882 0.983759 1.00583 Ago1 - Protein argonaute-1 - Mus musculus (Mouse) - Ago1 gene Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. May also be required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). Indicus|evm.model.CM009493.1.1163 Q9HCK5 AGO4_HUMAN 99.535 0.99768 1.00116 AGO4 - Protein argonaute-4 - Homo sapiens (Human) - AGO4 gene Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Indicus|evm.model.CM009493.1.1164 Q9HAW4 CLSPN_HUMAN 82.936 0.952211 1.04705 CLSPN - Claspin - Homo sapiens (Human) - CLSPN gene Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. Indicus|evm.model.CM009493.1.1165 Q8TAB5 CA216_HUMAN 85.526 0.986842 0.995633 C1orf216 - UPF0500 protein C1orf216 - Homo sapiens (Human) - C1orf216 gene Indicus|evm.model.CM009493.1.1166 Q5E9K0 PSB2_BOVIN 88.557 0.989189 0.920398 PSMB2 - Proteasome subunit beta type-2 - Bos taurus (Bovine) - PSMB2 gene Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Indicus|evm.model.CM009493.1.1167 Q6VUC0 AP2E_HUMAN 96.382 0.687075 0.997738 TFAP2E - Transcription factor AP-2-epsilon - Homo sapiens (Human) - TFAP2E gene Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). Indicus|evm.model.CM009493.1.1168 Q2KJ97 NCDN_BOVIN 100.000 0.99726 1.00137 NCDN - Neurochondrin - Bos taurus (Bovine) - NCDN gene Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (By similarity). Indicus|evm.model.CM009493.1.1170 Q95108 THIOM_BOVIN 55.856 0.803738 0.644578 TXN2 - Thioredoxin, mitochondrial precursor - Bos taurus (Bovine) - TXN2 gene Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity. Indicus|evm.model.CM009493.1.1171 Q8IZA0 K319L_HUMAN 95.020 0.772112 0.916111 KIAA0319L - Dyslexia-associated protein KIAA0319-like protein - Homo sapiens (Human) - KIAA0319L gene Possible role in axon guidance through interaction with RTN4R. Indicus|evm.model.CM009493.1.1172 Q5VZL5 ZMYM4_HUMAN 97.161 0.998711 1.00194 ZMYM4 - Zinc finger MYM-type protein 4 - Homo sapiens (Human) - ZMYM4 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Indicus|evm.model.CM009493.1.1173 Q8VIJ6 SFPQ_MOUSE 98.954 0.673729 1.01288 Sfpq - Splicing factor, proline- and glutamine-rich - Mus musculus (Mouse) - Sfpq gene DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (By similarity). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (PubMed:21680841, PubMed:22966205). Required for the assembly of nuclear speckles (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). Indicus|evm.model.CM009493.1.1174 Q5SVZ6 ZMYM1_HUMAN 78.769 0.990099 0.972855 ZMYM1 - Zinc finger MYM-type protein 1 - Homo sapiens (Human) - ZMYM1 gene Indicus|evm.model.CM009493.1.1175 O95789 ZMYM6_HUMAN 86.436 0.998486 0.996981 ZMYM6 - Zinc finger MYM-type protein 6 - Homo sapiens (Human) - ZMYM6 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Indicus|evm.model.CM009493.1.1176 Q8NCS4 TM35B_HUMAN 82.569 0.837209 0.837662 TMEM35B - Transmembrane protein 35B precursor - Homo sapiens (Human) - TMEM35B gene Indicus|evm.model.CM009493.1.1177 Q7L0L9 YA043_HUMAN 77.228 0.519126 0.83945 Transmembrane protein LOC653160 - Homo sapiens (Human) Indicus|evm.model.CM009493.1.1178 O95886 DLGP3_HUMAN 97.753 0.997959 1.00102 DLGAP3 - Disks large-associated protein 3 - Homo sapiens (Human) - DLGAP3 gene May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Indicus|evm.model.CM009493.1.1179 F6USH3 SIM12_HORSE 100.000 0.938144 1.05435 SMIM12 - Small integral membrane protein 12 - Equus caballus (Horse) - SMIM12 gene Indicus|evm.model.CM009493.1.1180 A4IFL1 CXA4_BOVIN 100.000 0.98951 0.858859 GJA4 - Gap junction alpha-4 protein - Bos taurus (Bovine) - GJA4 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009493.1.1181 Q58D78 CXB3_BOVIN 100.000 0.99262 1.0037 GJB3 - Gap junction beta-3 protein - Bos taurus (Bovine) - GJB3 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009493.1.1182 Q9NTQ9 CXB4_HUMAN 82.707 0.992509 1.00376 GJB4 - Gap junction beta-4 protein - Homo sapiens (Human) - GJB4 gene Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity). Indicus|evm.model.CM009493.1.1183 O95377 CXB5_HUMAN 80.952 0.992701 1.00366 GJB5 - Gap junction beta-5 protein - Homo sapiens (Human) - GJB5 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009493.1.1185 Q6P1W5 CA094_HUMAN 77.870 0.996678 1.00669 C1orf94 - Uncharacterized protein C1orf94 - Homo sapiens (Human) - C1orf94 gene Indicus|evm.model.CM009493.1.1186 Q7Z408 CSMD2_HUMAN 93.590 0.836957 0.0263837 CSMD2 - CUB and sushi domain-containing protein 2 - Homo sapiens (Human) - CSMD2 gene Indicus|evm.model.CM009493.1.1187 Q7Z408 CSMD2_HUMAN 97.059 0.978261 0.0395756 CSMD2 - CUB and sushi domain-containing protein 2 - Homo sapiens (Human) - CSMD2 gene Indicus|evm.model.CM009493.1.1188 Q32L34 HMGB4_BOVIN 100.000 0.989744 1.00515 HMGB4 - High mobility group protein B4 - Bos taurus (Bovine) - HMGB4 gene DNA binding, bending, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009493.1.1189 Q7Z408 CSMD2_HUMAN 96.541 0.093361 0.967594 CSMD2 - CUB and sushi domain-containing protein 2 - Homo sapiens (Human) - CSMD2 gene Indicus|evm.model.CM009493.1.1190 Q5R893 H2B1_PONAB 84.800 0.909091 0.960317 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009493.1.1191 P17040 ZSC20_HUMAN 82.010 0.89673 1.11409 ZSCAN20 - Zinc finger and SCAN domain-containing protein 20 - Homo sapiens (Human) - ZSCAN20 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009493.1.1192 Q17QM6 EFHD1_BOVIN 99.576 0.991561 1.00424 EFHD1 - EF-hand domain-containing protein D1 - Bos taurus (Bovine) - EFHD1 gene Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (By similarity). May play a role in neuronal differentiation (By similarity). Indicus|evm.model.CM009493.1.1194 Q6Y7W6 GGYF2_HUMAN 95.535 0.998452 0.994611 GIGYF2 - GRB10-interacting GYF protein 2 - Homo sapiens (Human) - GIGYF2 gene Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). Indicus|evm.model.CM009493.1.1195 Q6UX34 SNORC_HUMAN 81.818 0.935484 0.768595 SNORC - Protein SNORC precursor - Homo sapiens (Human) - SNORC gene Plays a role in the regulation of chondrocyte maturation and postnatal endochondral ossification. May inhibit cell growth stimulation induced by FGF2. Indicus|evm.model.CM009493.1.1196 Q8N5V2 NGEF_HUMAN 88.922 0.994012 0.940845 NGEF - Ephexin-1 - Homo sapiens (Human) - NGEF gene Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). Indicus|evm.model.CM009493.1.1197 Q9Y3R4 NEUR2_HUMAN 72.632 0.994737 1 NEU2 - Sialidase-2 - Homo sapiens (Human) - NEU2 gene Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed:14613940, PubMed:22228546). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed:14613940). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues (PubMed:14613940). Indicus|evm.model.CM009493.1.1198 Q92835 SHIP1_HUMAN 87.834 0.957465 1.00841 INPP5D - Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 - Homo sapiens (Human) - INPP5D gene Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8723348, PubMed:10764818, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:9108392, PubMed:10764818, PubMed:8769125). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. Indicus|evm.model.CM009493.1.1199 Q676U5 A16L1_HUMAN 94.069 0.996711 1.00165 ATG16L1 - Autophagy-related protein 16-1 - Homo sapiens (Human) - ATG16L1 gene Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). Indicus|evm.model.CM009493.1.1200 P08168 ARRS_BOVIN 99.505 0.995062 1.00248 SAG - S-arrestin - Bos taurus (Bovine) - SAG gene Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (PubMed:8003967, PubMed:25205354). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (By similarity). Indicus|evm.model.CM009493.1.1201 Q16760 DGKD_HUMAN 92.532 0.904355 1.05931 DGKD - Diacylglycerol kinase delta - Homo sapiens (Human) - DGKD gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). Indicus|evm.model.CM009493.1.1202 Q9NVE5 UBP40_HUMAN 83.657 0.998379 0.99919 USP40 - Ubiquitin carboxyl-terminal hydrolase 40 - Homo sapiens (Human) - USP40 gene May be catalytically inactive. Indicus|evm.model.CM009493.1.1203 P19224 UD16_HUMAN 72.963 0.468641 1.07895 UGT1A6 - UDP-glucuronosyltransferase 1-6 precursor - Homo sapiens (Human) - UGT1A6 gene UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). Indicus|evm.model.CM009493.1.1204 P35503 UD13_HUMAN 69.550 0.896875 0.599251 UGT1A3 - UDP-glucuronosyltransferase 1A3 precursor - Homo sapiens (Human) - UGT1A3 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23756265, PubMed:23288867, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515). Indicus|evm.model.CM009493.1.1205 P35503 UD13_HUMAN 68.858 0.937908 0.573034 UGT1A3 - UDP-glucuronosyltransferase 1A3 precursor - Homo sapiens (Human) - UGT1A3 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23756265, PubMed:23288867, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515). Indicus|evm.model.CM009493.1.1206 P35503 UD13_HUMAN 69.896 0.925806 0.580524 UGT1A3 - UDP-glucuronosyltransferase 1A3 precursor - Homo sapiens (Human) - UGT1A3 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23756265, PubMed:23288867, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515). Indicus|evm.model.CM009493.1.1207 Q64638 UD15_RAT 77.419 0.663043 0.173258 Ugt1a5 - UDP-glucuronosyltransferase 1A5 precursor - Rattus norvegicus (Rat) - Ugt1a5 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II. Indicus|evm.model.CM009493.1.1208 P35503 UD13_HUMAN 65.744 0.536449 1.00187 UGT1A3 - UDP-glucuronosyltransferase 1A3 precursor - Homo sapiens (Human) - UGT1A3 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23756265, PubMed:23288867, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515). Indicus|evm.model.CM009493.1.1209 P20720 UD12_RAT 70.189 0.848875 0.58349 Ugt1a2 - UDP-glucuronosyltransferase 1-2 precursor - Rattus norvegicus (Rat) - Ugt1a2 gene UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Indicus|evm.model.CM009493.1.1210 Q862Z4 DNJB3_MACFU 78.455 0.991837 1.0124 DNAJB3 - DnaJ homolog subfamily B member 3 - Macaca fuscata fuscata (Japanese macaque) - DNAJB3 gene May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins. Indicus|evm.model.CM009493.1.1211 P22309 UD11_HUMAN 78.987 0.996255 1.00188 UGT1A1 - UDP-glucuronosyltransferase 1A1 precursor - Homo sapiens (Human) - UGT1A1 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:18004206, PubMed:18004212, PubMed:18719240, PubMed:19830808, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004206, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:15472229, PubMed:18719240, PubMed:23288867). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (PubMed:17187418, PubMed:18004206, PubMed:19830808). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558). Indicus|evm.model.CM009493.1.1212 A6NES4 MRO2A_HUMAN 81.466 0.983558 1.01732 MROH2A - Maestro heat-like repeat-containing protein family member 2A - Homo sapiens (Human) - MROH2A gene Indicus|evm.model.CM009493.1.1213 D3Z750 MRO2A_MOUSE 80.526 0.618056 0.171531 Mroh2a - Maestro heat-like repeat-containing protein family member 2A - Mus musculus (Mouse) - Mroh2a gene Indicus|evm.model.CM009493.1.1214 Q8NCD3 HJURP_HUMAN 55.650 0.992847 0.934492 HJURP - Holliday junction recognition protein - Homo sapiens (Human) - HJURP gene Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. Indicus|evm.model.CM009493.1.1215 Q7Z2W7 TRPM8_HUMAN 93.981 0.983592 0.993659 TRPM8 - Transient receptor potential cation channel subfamily M member 8 - Homo sapiens (Human) - TRPM8 gene Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. Indicus|evm.model.CM009493.1.1216 Q27967 SPP24_BOVIN 100.000 0.957346 1.03941 SPP2 - Secreted phosphoprotein 24 precursor - Bos taurus (Bovine) - SPP2 gene Could coordinate an aspect of bone turnover. Indicus|evm.model.CM009493.1.1217 P61208 ARL4C_MOUSE 100.000 0.989637 1.00521 Arl4c - ADP-ribosylation factor-like protein 4C - Mus musculus (Mouse) - Arl4c gene Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process (By similarity). Indicus|evm.model.CM009493.1.1220 Q9P0V3 SH3B4_HUMAN 91.900 0.997925 1.00104 SH3BP4 - SH3 domain-binding protein 4 - Homo sapiens (Human) - SH3BP4 gene May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. Indicus|evm.model.CM009493.1.1223 Q9UPQ3 AGAP1_HUMAN 96.923 0.716336 1.05718 AGAP1 - Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 - Homo sapiens (Human) - AGAP1 gene GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. Indicus|evm.model.CM009493.1.1224 P52951 GBX2_HUMAN 98.281 0.994286 1.00575 GBX2 - Homeobox protein GBX-2 - Homo sapiens (Human) - GBX2 gene May act as a transcription factor for cell pluripotency and differentiation in the embryo. Indicus|evm.model.CM009493.1.1225 Q6ZVZ8 ASB18_HUMAN 72.222 0.170418 0.667382 ASB18 - Ankyrin repeat and SOCS box protein 18 - Homo sapiens (Human) - ASB18 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009493.1.1226 Q6ZVZ8 ASB18_HUMAN 71.014 0.641509 0.227468 ASB18 - Ankyrin repeat and SOCS box protein 18 - Homo sapiens (Human) - ASB18 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009493.1.1227 Q86XH1 DRC11_HUMAN 86.755 0.220264 0.828467 IQCA1 - Dynein regulatory complex protein 11 - Homo sapiens (Human) - IQCA1 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Indicus|evm.model.CM009493.1.1228 P11613 ACKR3_CANLF 92.541 0.99449 1.00276 ACKR3 - Atypical chemokine receptor 3 - Canis lupus familiaris (Dog) - ACKR3 gene Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development (By similarity). Indicus|evm.model.CM009493.1.1229 Q99627 CSN8_HUMAN 96.651 0.806202 1.23445 COPS8 - COP9 signalosome complex subunit 8 - Homo sapiens (Human) - COPS8 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Indicus|evm.model.CM009493.1.1230 P15989 CO6A3_CHICK 65.647 0.855732 1.06503 COL6A3 - Collagen alpha-3(VI) chain precursor - Gallus gallus (Chicken) - COL6A3 gene Collagen VI acts as a cell-binding protein. Indicus|evm.model.CM009493.1.1231 P62250 RS16_RAT 97.945 0.986301 1 Rps16 - 40S ribosomal protein S16 - Rattus norvegicus (Rat) - Rps16 gene cytosolic small ribosomal subunit, small ribosomal subunit, RNA binding, structural constituent of ribosome, cellular response to leukemia inhibitory factor, liver regeneration, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit biogenesis, rRNA processing, translation Indicus|evm.model.CM009493.1.1233 P81264 PRRP_BOVIN 100.000 0.137784 7.18367 PRLH - Prolactin-releasing peptide precursor - Bos taurus (Bovine) - PRLH gene Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL. Indicus|evm.model.CM009493.1.1234 Q9H0T7 RAB17_HUMAN 62.441 0.989011 0.858491 RAB17 - Ras-related protein Rab-17 - Homo sapiens (Human) - RAB17 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration. Indicus|evm.model.CM009493.1.1235 Q32MZ4 LRRF1_HUMAN 81.757 0.621359 0.509901 LRRFIP1 - Leucine-rich repeat flightless-interacting protein 1 - Homo sapiens (Human) - LRRFIP1 gene Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Indicus|evm.model.CM009493.1.1236 E1BC15 RBM44_BOVIN 98.291 0.998097 1 RBM44 - RNA-binding protein 44 - Bos taurus (Bovine) - RBM44 gene Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity). Indicus|evm.model.CM009493.1.1237 O60894 RAMP1_HUMAN 74.419 0.815287 1.06081 RAMP1 - Receptor activity-modifying protein 1 precursor - Homo sapiens (Human) - RAMP1 gene Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. Indicus|evm.model.CM009493.1.1239 Q1RMW1 UBE2F_BOVIN 100.000 0.989247 1.00541 UBE2F - NEDD8-conjugating enzyme UBE2F - Bos taurus (Bovine) - UBE2F gene Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. Indicus|evm.model.CM009493.1.1240 A2VDS1 SCLY_BOVIN 99.771 0.995434 1.00229 SCLY - Selenocysteine lyase - Bos taurus (Bovine) - SCLY gene Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. Indicus|evm.model.CM009493.1.1241 Q9ET47 ESPN_MOUSE 78.571 0.0246126 1.25947 Espn - Espin - Mus musculus (Mouse) - Espn gene Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:14657236, PubMed:15190118). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (PubMed:21455486). Involved in the elongation of actin in stereocilia (PubMed:19287378, PubMed:22264607). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation (PubMed:26926603). Indicus|evm.model.CM009493.1.1242 Q0D2K2 KLH30_HUMAN 87.540 0.971963 0.555363 KLHL30 - Kelch-like protein 30 - Homo sapiens (Human) - KLHL30 gene Indicus|evm.model.CM009493.1.1243 Q0D2K2 KLH30_HUMAN 88.372 0.986175 0.375433 KLHL30 - Kelch-like protein 30 - Homo sapiens (Human) - KLHL30 gene Indicus|evm.model.CM009493.1.1244 Q4G0M1 ERFE_HUMAN 87.931 0.279412 0.576271 ERFE - Erythroferrone precursor - Homo sapiens (Human) - ERFE gene Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Indicus|evm.model.CM009493.1.1245 Q0IIF0 ILKAP_BOVIN 100.000 0.956284 0.989189 ILKAP - Integrin-linked kinase-associated serine/threonine phosphatase 2C - Bos taurus (Bovine) - ILKAP gene Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity). Indicus|evm.model.CM009493.1.1246 Q96HZ4 HES6_HUMAN 87.111 0.99115 1.00893 HES6 - Transcription cofactor HES-6 - Homo sapiens (Human) - HES6 gene Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). Indicus|evm.model.CM009493.1.1247 O15055 PER2_HUMAN 64.626 0.966622 0.596813 PER2 - Period circadian protein homolog 2 - Homo sapiens (Human) - PER2 gene Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-ARTNL/BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-ARTNL/BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like ARNTL or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. Indicus|evm.model.CM009493.1.1248 O15055 PER2_HUMAN 82.931 0.985348 0.43506 PER2 - Period circadian protein homolog 2 - Homo sapiens (Human) - PER2 gene Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-ARTNL/BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-ARTNL/BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like ARNTL or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. Indicus|evm.model.CM009493.1.1249 Q9Y576 ASB1_HUMAN 96.573 0.334029 2.8597 ASB1 - Ankyrin repeat and SOCS box protein 1 - Homo sapiens (Human) - ASB1 gene May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009493.1.1251 P97831 TWST2_RAT 100.000 0.987578 1.00625 Twist2 - Twist-related protein 2 - Rattus norvegicus (Rat) - Twist2 gene Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity). Indicus|evm.model.CM009493.1.1254 Q9UPS8 ANR26_HUMAN 67.320 0.752475 0.118129 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009493.1.1255 Q9D6Y1 CCDC3_MOUSE 86.916 0.711409 0.545788 Ccdc3 - Coiled-coil domain-containing protein 3 precursor - Mus musculus (Mouse) - Ccdc3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells (PubMed:25605713). Indicus|evm.model.CM009493.1.1256 P56524 HDAC4_HUMAN 92.007 0.942156 1.05258 HDAC4 - Histone deacetylase 4 - Homo sapiens (Human) - HDAC4 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). Indicus|evm.model.CM009493.1.1257 P15509 CSF2R_HUMAN 56.495 0.692632 1.1875 CSF2RA - Granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor - Homo sapiens (Human) - CSF2RA gene Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Indicus|evm.model.CM009493.1.1262 P34942 NDUAA_BOVIN 100.000 0.542857 0.306122 NDUFA10 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor - Bos taurus (Bovine) - NDUFA10 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009493.1.1263 P34942 NDUAA_BOVIN 97.727 0.992453 0.772595 NDUFA10 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor - Bos taurus (Bovine) - NDUFA10 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009493.1.1264 Q3MHR0 LYPA1_BOVIN 93.567 0.982659 0.752174 LYPLA1 - Acyl-protein thioesterase 1 - Bos taurus (Bovine) - LYPLA1 gene Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Has depalmitoylating activity toward KCNMA1 (By similarity). Could also depalmitoylate ADRB2 (By similarity). Acts as a lysophospholipase hydrolyzing various lysophospholipids including lysophosphatidylcholine (lyso-PC), lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (By similarity). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity). Indicus|evm.model.CM009493.1.1265 Q6DDA3 CSN9_XENTR 100.000 0.275 2.80702 cops9 - COP9 signalosome complex subunit 9 - Xenopus tropicalis (Western clawed frog) - cops9 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity. May play a role in cell proliferation. Indicus|evm.model.CM009493.1.1266 Q8NHW6 OTOSP_HUMAN 92.754 0.221498 3.44944 OTOS - Otospiralin precursor - Homo sapiens (Human) - OTOS gene May be essential for the survival of the neurosensory epithelium of the inner ear. Indicus|evm.model.CM009493.1.1268 Q9P2S6 ANKY1_HUMAN 67.842 0.847395 0.856536 ANKMY1 - Ankyrin repeat and MYND domain-containing protein 1 - Homo sapiens (Human) - ANKMY1 gene Indicus|evm.model.CM009493.1.1269 G5E872 RNPL1_MOUSE 94.928 0.907285 0.209722 Rnpepl1 - Aminopeptidase RNPEPL1 - Mus musculus (Mouse) - Rnpepl1 gene Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine. Indicus|evm.model.CM009493.1.1270 G5E872 RNPL1_MOUSE 94.472 0.994845 0.538889 Rnpepl1 - Aminopeptidase RNPEPL1 - Mus musculus (Mouse) - Rnpepl1 gene Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine. Indicus|evm.model.CM009493.1.1271 Q95LP4 CAN10_MACFA 79.193 0.907258 0.759571 CAPN10 - Calpain-10 - Macaca fascicularis (Crab-eating macaque) - CAPN10 gene Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity). Indicus|evm.model.CM009493.1.1273 G3X745 GPC1_BOVIN 94.545 0.0859873 1.12343 GPC1 - Glypican-1 precursor - Bos taurus (Bovine) - GPC1 gene Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling (By similarity). Indicus|evm.model.CM009493.1.1274 Q9ES66 CAN10_RAT 80.000 0.717391 0.207207 Capn10 - Calpain-10 - Rattus norvegicus (Rat) - Capn10 gene Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity). Indicus|evm.model.CM009493.1.1275 Q9HC97 GPR35_HUMAN 69.145 0.876667 0.970874 GPR35 - G-protein coupled receptor 35 - Homo sapiens (Human) - GPR35 gene Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins. Indicus|evm.model.CM009493.1.1276 G3X745 GPC1_BOVIN 94.841 0.902439 0.953488 GPC1 - Glypican-1 precursor - Bos taurus (Bovine) - GPC1 gene Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling (By similarity). Indicus|evm.model.CM009493.1.1277 Q8CHJ2 AQP12_MOUSE 69.767 0.866397 0.851724 Aqp12 - Aquaporin-12 - Mus musculus (Mouse) - Aqp12 gene Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. Indicus|evm.model.CM009493.1.1278 Q12756 KIF1A_HUMAN 98.032 0.484814 1.05207 KIF1A - Kinesin-like protein KIF1A - Homo sapiens (Human) - KIF1A gene Motor for anterograde axonal transport of synaptic vesicle precursors. Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. Indicus|evm.model.CM009493.1.1279 P21549 SPYA_HUMAN 80.357 0.942169 1.05867 AGXT - Serine--pyruvate aminotransferase - Homo sapiens (Human) - AGXT gene cytosol, intracellular membrane-bounded organelle, peroxisomal matrix, peroxisome, alanine-glyoxylate transaminase activity, amino acid binding, identical protein binding, protein homodimerization activity, protein self-association, pyridoxal phosphate binding Indicus|evm.model.CM009493.1.1280 Q08AI8 MB214_HUMAN 77.752 0.993151 0.979866 MAB21L4 - Protein mab-21-like 4 - Homo sapiens (Human) - MAB21L4 gene Indicus|evm.model.CM009493.1.1281 H7BZ55 CRCC2_HUMAN 61.283 0.997828 0.835451 CROCC2 - Ciliary rootlet coiled-coil protein 2 - Homo sapiens (Human) - CROCC2 gene Indicus|evm.model.CM009493.1.1282 Q8TER0 SNED1_HUMAN 87.943 0.96988 0.822364 SNED1 - Sushi, nidogen and EGF-like domain-containing protein 1 precursor - Homo sapiens (Human) - SNED1 gene Notch binding Indicus|evm.model.CM009493.1.1283 Q7Z6M4 MTEF4_HUMAN 73.731 0.973373 0.887139 MTERF4 - Transcription termination factor 4, mitochondrial precursor - Homo sapiens (Human) - MTERF4 gene Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S). Indicus|evm.model.CM009493.1.1284 Q96RG2 PASK_HUMAN 67.936 0.968869 0.995465 PASK - PAS domain-containing serine/threonine-protein kinase - Homo sapiens (Human) - PASK gene Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. Indicus|evm.model.CM009493.1.1285 Q3T0W4 PP1R7_BOVIN 100.000 0.99446 1.00278 PPP1R7 - Protein phosphatase 1 regulatory subunit 7 - Bos taurus (Bovine) - PPP1R7 gene Regulatory subunit of protein phosphatase 1. Inactivates the PPP1CC isoform 2 during epididymal sperm maturation. Indicus|evm.model.CM009493.1.1288 Q8VDJ3 VIGLN_MOUSE 75.133 0.896787 0.809937 Hdlbp - Vigilin - Mus musculus (Mouse) - Hdlbp gene Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity). Indicus|evm.model.CM009493.1.1289 Q2NKY7 SEPT2_BOVIN 90.028 0.605455 1.52355 SEPTIN2 - Septin-2 - Bos taurus (Bovine) - SEPTIN2 gene Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein (By similarity). Indicus|evm.model.CM009493.1.1290 O94887 FARP2_HUMAN 68.687 0.924528 0.100569 FARP2 - FERM, ARHGEF and pleckstrin domain-containing protein 2 - Homo sapiens (Human) - FARP2 gene Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). Indicus|evm.model.CM009493.1.1291 Q91VS8 FARP2_MOUSE 86.538 0.291429 0.164319 Farp2 - FERM, ARHGEF and pleckstrin domain-containing protein 2 - Mus musculus (Mouse) - Farp2 gene Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity (PubMed:23375260 and PubMed:20702777). Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion. Indicus|evm.model.CM009493.1.1292 O94887 FARP2_HUMAN 87.705 0.234496 0.489564 FARP2 - FERM, ARHGEF and pleckstrin domain-containing protein 2 - Homo sapiens (Human) - FARP2 gene Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). Indicus|evm.model.CM009493.1.1293 Q3SWY6 STK25_BOVIN 100.000 0.995316 1.00235 STK25 - Serine/threonine-protein kinase 25 - Bos taurus (Bovine) - STK25 gene Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration (By similarity). Indicus|evm.model.CM009493.1.1294 Q9UMX3 BOK_HUMAN 93.970 0.99 0.943396 BOK - Bcl-2-related ovarian killer protein - Homo sapiens (Human) - BOK gene Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155). Indicus|evm.model.CM009493.1.1295 Q2TBI2 THAP4_BOVIN 98.748 0.93 1.0274 THAP4 - Peroxynitrite isomerase THAP4 - Bos taurus (Bovine) - THAP4 gene In vitro catalyzes the heme-based conversion of peroxynitrite into nitrate/NO3-. May be involved in the detoxification of peroxynitrite which is responsible for the nitration of L-free tyrosine. Also selectively binds nitric oxide/NO in vitro. Indicus|evm.model.CM009493.1.1296 Q6PZ03 ATG4B_BOVIN 99.743 0.820296 1.20356 ATG4B - Cysteine protease ATG4B - Bos taurus (Bovine) - ATG4B gene Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity). Indicus|evm.model.CM009493.1.1297 P23919 KTHY_HUMAN 83.412 0.985915 1.00472 DTYMK - Thymidylate kinase - Homo sapiens (Human) - DTYMK gene Catalyzes the conversion of dTMP to dTDP. Indicus|evm.model.CM009493.1.1298 Q8WYH8 ING5_HUMAN 96.476 0.570707 1.65 ING5 - Inhibitor of growth protein 5 - Homo sapiens (Human) - ING5 gene Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). Indicus|evm.model.CM009493.1.1299 Q1JPD3 D2HDH_BOVIN 99.632 0.99633 1.00184 D2HGDH - D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - D2HGDH gene Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate. Indicus|evm.model.CM009493.1.1300 Q6XQG9 G3ST2_PIG 78.663 0.960396 1.01508 GAL3ST2 - Galactose-3-O-sulfotransferase 2 - Sus scrofa (Pig) - GAL3ST2 gene Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency (By similarity). Indicus|evm.model.CM009493.1.1301 Q8WWR8 NEUR4_HUMAN 73.770 0.995825 0.989669 NEU4 - Sialidase-4 - Homo sapiens (Human) - NEU4 gene Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15847605, PubMed:21521691, PubMed:15213228). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605). Indicus|evm.model.CM009493.1.1302 Q15116 PDCD1_HUMAN 63.793 0.992933 0.982639 PDCD1 - Programmed cell death protein 1 precursor - Homo sapiens (Human) - PDCD1 gene Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity). Indicus|evm.model.CM009493.1.1305 A0A1B0GVR7 F240C_HUMAN 55.914 0.267442 3.62105 FAM240C - Protein FAM240C - Homo sapiens (Human) - FAM240C gene Indicus|evm.model.CM009493.1.1306 Q9Y2W2 WBP11_HUMAN 89.076 0.861314 0.213729 WBP11 - WW domain-binding protein 11 - Homo sapiens (Human) - WBP11 gene Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. Indicus|evm.model.CM009493.1.1307 Q9Y2W2 WBP11_HUMAN 79.798 0.592593 0.25273 WBP11 - WW domain-binding protein 11 - Homo sapiens (Human) - WBP11 gene Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. Indicus|evm.model.CM009493.1.1308 D6RBQ6 U17LH_HUMAN 52.022 0.96 0.707547 USP17L17 - Ubiquitin carboxyl-terminal hydrolase 17-like protein 17 - Homo sapiens (Human) - USP17L17 gene Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. Indicus|evm.model.CM009494.1.3 Q8TAG5 VTM2A_HUMAN 91.579 0.721374 1.11017 VSTM2A - V-set and transmembrane domain-containing protein 2A precursor - Homo sapiens (Human) - VSTM2A gene Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway. Indicus|evm.model.CM009494.1.4 Q15125 EBP_HUMAN 52.427 0.97561 0.356522 EBP - 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase - Homo sapiens (Human) - EBP gene Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. Indicus|evm.model.CM009494.1.5 Q9CVD2 ATX3_MOUSE 77.586 0.966102 0.166197 Atxn3 - Ataxin-3 - Mus musculus (Mouse) - Atxn3 gene Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:21855799). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). Indicus|evm.model.CM009494.1.6 D3ZUI5 COBL_RAT 71.925 0.282238 1.08826 Cobl - Protein cordon-bleu - Rattus norvegicus (Rat) - Cobl gene Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates dendrite branching in Purkinje cells (By similarity). Regulates neuron morphogenesis and increases branching of axons and dendrites. Indicus|evm.model.CM009494.1.8 B5KFD7 GRB10_PIG 91.171 0.917188 1.08659 Grb10 - Growth factor receptor-bound protein 10 - Sus scrofa (Pig) - Grb10 gene Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2 (By similarity). Indicus|evm.model.CM009494.1.10 P27718 DDC_BOVIN 90.909 0.828947 0.936345 DDC - Aromatic-L-amino-acid decarboxylase - Bos taurus (Bovine) - DDC gene Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Indicus|evm.model.CM009494.1.11 P27718 DDC_BOVIN 99.038 0.474654 0.445585 DDC - Aromatic-L-amino-acid decarboxylase - Bos taurus (Bovine) - DDC gene Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Indicus|evm.model.CM009494.1.12 Q6PIW4 FIGL1_HUMAN 85.377 0.99705 1.00593 FIGNL1 - Fidgetin-like protein 1 - Homo sapiens (Human) - FIGNL1 gene Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity). Indicus|evm.model.CM009494.1.13 Q13422 IKZF1_HUMAN 90.559 0.971857 1.02697 IKZF1 - DNA-binding protein Ikaros - Homo sapiens (Human) - IKZF1 gene Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). Indicus|evm.model.CM009494.1.16 A4D263 SPT48_HUMAN 81.463 0.639498 0.728311 SPATA48 - Spermatogenesis-associated protein 48 - Homo sapiens (Human) - SPATA48 gene Indicus|evm.model.CM009494.1.17 Q29108 ZPBP1_PIG 80.857 0.993355 0.86 ZPBP - Zona pellucida-binding protein 1 precursor - Sus scrofa (Pig) - ZPBP gene Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization. Indicus|evm.model.CM009494.1.18 Q2TAL6 VWC2_HUMAN 89.455 0.954704 0.883077 VWC2 - Brorin precursor - Homo sapiens (Human) - VWC2 gene BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity). Indicus|evm.model.CM009494.1.21 P62755 RS6_RAT 87.402 0.984252 0.51004 Rps6 - 40S ribosomal protein S6 - Rattus norvegicus (Rat) - Rps6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009494.1.25 Q16831 UPP1_HUMAN 80.323 0.993548 1 UPP1 - Uridine phosphorylase 1 - Homo sapiens (Human) - UPP1 gene Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Indicus|evm.model.CM009494.1.26 A0JNL1 CG057_BOVIN 99.306 0.99308 1.00347 Uncharacterized protein C7orf57 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009494.1.27 Q0II64 SUN3_BOVIN 99.444 0.99446 1.00278 SUN3 - SUN domain-containing protein 3 - Bos taurus (Bovine) - SUN3 gene As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. Indicus|evm.model.CM009494.1.28 Q0IIL2 CLD12_BOVIN 100.000 0.991837 1.0041 CLDN12 - Claudin-12 - Bos taurus (Bovine) - CLDN12 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009494.1.29 P0DTF9 PTIP2_HUMAN 52.564 0.986928 0.993506 PTTG1IP2 - PTTG1IP family member 2 precursor - Homo sapiens (Human) - PTTG1IP2 gene Indicus|evm.model.CM009494.1.30 B6A7Q3 CDK14_RABIT 93.750 0.418919 0.15812 CDK14 - Cyclin-dependent kinase 14 - Oryctolagus cuniculus (Rabbit) - CDK14 gene Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity). Indicus|evm.model.CM009494.1.32 B0VXE8 CDK14_CALJA 100.000 0.645833 0.22695 CDK14 - Cyclin-dependent kinase 14 - Callithrix jacchus (White-tufted-ear marmoset) - CDK14 gene Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity). Indicus|evm.model.CM009494.1.34 Q9UP38 FZD1_HUMAN 96.621 0.996904 0.998454 FZD1 - Frizzled-1 precursor - Homo sapiens (Human) - FZD1 gene Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Indicus|evm.model.CM009494.1.36 Q62725 NFYC_RAT 77.778 0.835294 0.507463 Nfyc - Nuclear transcription factor Y subunit gamma - Rattus norvegicus (Rat) - Nfyc gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. Indicus|evm.model.CM009494.1.37 Q99551 MTEF1_HUMAN 80.418 0.964646 0.992481 MTERF1 - Transcription termination factor 1, mitochondrial precursor - Homo sapiens (Human) - MTERF1 gene Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. Indicus|evm.model.CM009494.1.38 Q99996 AKAP9_HUMAN 85.123 0.999484 0.992321 AKAP9 - A-kinase anchor protein 9 - Homo sapiens (Human) - AKAP9 gene Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). Indicus|evm.model.CM009494.1.39 Q4PJW3 CP51A_BOVIN 100.000 0.996024 1.00199 CYP51A1 - Lanosterol 14-alpha demethylase - Bos taurus (Bovine) - CYP51A1 gene A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.CM009494.1.40 A4D1F6 LRRD1_HUMAN 77.650 0.997685 1.00465 LRRD1 - Leucine-rich repeat and death domain-containing protein 1 - Homo sapiens (Human) - LRRD1 gene positive regulation of Ras protein signal transduction, signal transduction Indicus|evm.model.CM009494.1.41 Q6TNJ1 KRIT1_BOVIN 99.457 0.997286 1.00136 KRIT1 - Krev interaction trapped protein 1 - Bos taurus (Bovine) - KRIT1 gene Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner (By similarity). Indicus|evm.model.CM009494.1.42 Q9P2G1 AKIB1_HUMAN 95.513 0.960352 1.04224 ANKIB1 - Ankyrin repeat and IBR domain-containing protein 1 - Homo sapiens (Human) - ANKIB1 gene Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. Indicus|evm.model.CM009494.1.44 A2VDY6 GATA1_BOVIN 100.000 0.554545 0.404412 GATAD1 - GATA zinc finger domain-containing protein 1 - Bos taurus (Bovine) - GATAD1 gene nucleus, chromatin organization Indicus|evm.model.CM009494.1.45 O43933 PEX1_HUMAN 87.451 0.99844 0.999221 PEX1 - Peroxisome biogenesis factor 1 - Homo sapiens (Human) - PEX1 gene Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Indicus|evm.model.CM009494.1.46 A6QPE1 RBM48_BOVIN 98.343 0.99449 1.00276 RBM48 - RNA-binding protein 48 - Bos taurus (Bovine) - RBM48 gene nucleoplasm Indicus|evm.model.CM009494.1.47 Q3KQ77 EFCB1_XENLA 59.896 0.964646 0.951923 efcab1 - EF-hand calcium-binding domain-containing protein 1 - Xenopus laevis (African clawed frog) - efcab1 gene Indicus|evm.model.CM009494.1.48 Q5BKY9 F133B_HUMAN 95.951 0.991935 1.00405 FAM133B - Protein FAM133B - Homo sapiens (Human) - FAM133B gene RNA binding Indicus|evm.model.CM009494.1.49 Q00534 CDK6_HUMAN 97.581 0.991968 0.763804 CDK6 - Cyclin-dependent kinase 6 - Homo sapiens (Human) - CDK6 gene Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). Indicus|evm.model.CM009494.1.50 Q5K651 SAMD9_HUMAN 80.176 0.998736 0.995595 SAMD9 - Sterile alpha motif domain-containing protein 9 - Homo sapiens (Human) - SAMD9 gene May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion. Indicus|evm.model.CM009494.1.51 A6QQC6 HECA2_BOVIN 98.758 0.954455 1.02851 HEPACAM2 - HEPACAM family member 2 precursor - Bos taurus (Bovine) - HEPACAM2 gene Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation (By similarity). Indicus|evm.model.CM009494.1.52 Q96JG6 VPS50_HUMAN 97.822 0.997927 1.00104 VPS50 - Syndetin - Homo sapiens (Human) - VPS50 gene Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Indicus|evm.model.CM009494.1.53 P25117 CALCR_PIG 81.013 0.840741 1.08434 CALCR - Calcitonin receptor precursor - Sus scrofa (Pig) - CALCR gene This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells. Indicus|evm.model.CM009494.1.54 Q7YRQ8 TFPI2_BOVIN 100.000 0.991489 1.00427 TFPI2 - Tissue factor pathway inhibitor 2 precursor - Bos taurus (Bovine) - TFPI2 gene May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. Indicus|evm.model.CM009494.1.55 P02698 GBG1_BOVIN 100.000 0.973333 1.01351 GNGT1 - Guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor - Bos taurus (Bovine) - GNGT1 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009494.1.56 O15155 BET1_HUMAN 95.763 0.983193 1.00847 BET1 - BET1 homolog - Homo sapiens (Human) - BET1 gene Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). Indicus|evm.model.CM009494.1.57 P02465 CO1A2_BOVIN 100.000 0.998535 1.00073 COL1A2 - Collagen alpha-2(I) chain precursor - Bos taurus (Bovine) - COL1A2 gene Type I collagen is a member of group I collagen (fibrillar forming collagen). Indicus|evm.model.CM009494.1.58 Q96PB1 CASD1_HUMAN 97.115 0.997257 0.91468 CASD1 - N-acetylneuraminate 9-O-acetyltransferase - Homo sapiens (Human) - CASD1 gene O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids (PubMed:20947662, PubMed:26169044). Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and are involved in various processes such as cell-cell interactions, host-pathogen recognition (PubMed:20947662, PubMed:26169044). Indicus|evm.model.CM009494.1.59 Q29S03 SGCE_BOVIN 100.000 0.995434 1.00229 SGCE - Epsilon-sarcoglycan - Bos taurus (Bovine) - SGCE gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Indicus|evm.model.CM009494.1.60 Q86TG7 PEG10_HUMAN 90.491 0.800493 0.573446 PEG10 - Retrotransposon-derived protein PEG10 - Homo sapiens (Human) - PEG10 gene Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis (PubMed:12810624). May also have a role in cell growth promotion and hepatoma formation (PubMed:12810624, PubMed:16423995). Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ACVRL1 (PubMed:15611116). When overexpressed, induces the formation of cellular extension, such as filipodia in association with ACVRL1 (PubMed:15611116). Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity). Indicus|evm.model.CM009494.1.61 Q86TG7 PEG10_HUMAN 92.401 0.913165 0.504237 PEG10 - Retrotransposon-derived protein PEG10 - Homo sapiens (Human) - PEG10 gene Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis (PubMed:12810624). May also have a role in cell growth promotion and hepatoma formation (PubMed:12810624, PubMed:16423995). Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ACVRL1 (PubMed:15611116). When overexpressed, induces the formation of cellular extension, such as filipodia in association with ACVRL1 (PubMed:15611116). Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity). Indicus|evm.model.CM009494.1.62 Q9ULJ8 NEB1_HUMAN 89.444 0.129474 1.19581 PPP1R9A - Neurabin-1 - Homo sapiens (Human) - PPP1R9A gene Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity). Indicus|evm.model.CM009494.1.63 P27169 PON1_HUMAN 81.972 0.994382 1.00282 PON1 - Serum paraoxonase/arylesterase 1 - Homo sapiens (Human) - PON1 gene Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. Indicus|evm.model.CM009494.1.64 Q15166 PON3_HUMAN 75.141 0.993939 0.932203 PON3 - Serum paraoxonase/lactonase 3 - Homo sapiens (Human) - PON3 gene Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. Indicus|evm.model.CM009494.1.65 Q58DS7 PON2_BOVIN 100.000 0.994366 1.00282 PON2 - Serum paraoxonase/arylesterase 2 - Bos taurus (Bovine) - PON2 gene Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Indicus|evm.model.CM009494.1.66 Q9Y574 ASB4_HUMAN 95.604 0.997253 0.85446 ASB4 - Ankyrin repeat and SOCS box protein 4 - Homo sapiens (Human) - ASB4 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity). Indicus|evm.model.CM009494.1.67 Q5R893 H2B1_PONAB 94.444 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009494.1.68 Q16654 PDK4_HUMAN 91.912 0.985294 0.992701 PDK4 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial precursor - Homo sapiens (Human) - PDK4 gene Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. Indicus|evm.model.CM009494.1.69 O88485 DC1I1_MOUSE 97.771 0.961656 1.03822 Dync1i1 - Cytoplasmic dynein 1 intermediate chain 1 - Mus musculus (Mouse) - Dync1i1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. Indicus|evm.model.CM009494.1.70 Q9UJS0 CMC2_HUMAN 97.313 0.997019 0.994074 SLC25A13 - Calcium-binding mitochondrial carrier protein Aralar2 - Homo sapiens (Human) - SLC25A13 gene Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane (PubMed:11566871, PubMed:25410934). May have a function in the urea cycle (PubMed:11566871). Indicus|evm.model.CM009494.1.71 Q4R7Y2 RL10_MACFA 78.378 0.973333 0.350467 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009494.1.72 P61486 RL36A_TAKRU 94.253 0.551948 1.45283 rpl36a - 60S ribosomal protein L36a - Takifugu rubripes (Japanese pufferfish) - rpl36a gene Indicus|evm.model.CM009494.1.74 P60897 SEM1_MOUSE 100.000 0.341085 1.84286 Sem1 - 26S proteasome complex subunit SEM1 - Mus musculus (Mouse) - Sem1 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells. Indicus|evm.model.CM009494.1.75 P26583 HMGB2_HUMAN 100.000 0.987421 0.760766 HMGB2 - High mobility group protein B2 - Homo sapiens (Human) - HMGB2 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). Indicus|evm.model.CM009494.1.76 P70397 DLX6_MOUSE 99.429 0.87 1.14286 Dlx6 - Homeobox protein DLX-6 - Mus musculus (Mouse) - Dlx6 gene DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, anatomical structure formation involved in morphogenesis, cell differentiation, embryonic limb morphogenesis, epithelial cell differentiation, head development, inner ear morphogenesis, positive regulation of epithelial cell proliferation Indicus|evm.model.CM009494.1.77 P56178 DLX5_HUMAN 97.578 0.993103 1.00346 DLX5 - Homeobox protein DLX-5 - Homo sapiens (Human) - DLX5 gene Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. Indicus|evm.model.CM009494.1.78 A6QNT8 SC24A_BOVIN 100.000 0.897059 0.123749 SEC24A - Protein transport protein Sec24A - Bos taurus (Bovine) - SEC24A gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes. Indicus|evm.model.CM009494.1.79 A6QNT8 SC24A_BOVIN 99.096 0.973529 0.309372 SEC24A - Protein transport protein Sec24A - Bos taurus (Bovine) - SEC24A gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes. Indicus|evm.model.CM009494.1.80 Q0P574 SDHF3_BOVIN 91.667 0.443038 0.632 SDHAF3 - Succinate dehydrogenase assembly factor 3, mitochondrial precursor - Bos taurus (Bovine) - SDHAF3 gene Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. Indicus|evm.model.CM009494.1.82 P01289 TKN1_BOVIN 98.462 0.832258 1.19231 TAC1 - Protachykinin-1 precursor - Bos taurus (Bovine) - TAC1 gene Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Indicus|evm.model.CM009494.1.83 Q1LZA3 ASNS_BOVIN 100.000 0.996441 1.00178 ASNS - Asparagine synthetase [glutamine-hydrolyzing] - Bos taurus (Bovine) - ASNS gene cytosol, asparagine synthase (glutamine-hydrolyzing) activity, asparagine biosynthetic process Indicus|evm.model.CM009494.1.85 Q0VC84 C1GLT_BOVIN 98.300 0.742616 1.28804 C1GALT1 - Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 - Bos taurus (Bovine) - C1GALT1 gene Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity). Indicus|evm.model.CM009494.1.86 Q2UY09 COSA1_HUMAN 70.052 0.998071 0.921778 COL28A1 - Collagen alpha-1(XXVIII) chain precursor - Homo sapiens (Human) - COL28A1 gene May act as a cell-binding protein. Indicus|evm.model.CM009494.1.87 Q9NXC5 MIO_HUMAN 97.489 0.997719 1.00229 MIOS - GATOR complex protein MIOS - Homo sapiens (Human) - MIOS gene As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). Indicus|evm.model.CM009494.1.88 P35244 RFA3_HUMAN 86.667 0.97541 1.00826 RPA3 - Replication protein A 14 kDa subunit - Homo sapiens (Human) - RPA3 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). Indicus|evm.model.CM009494.1.90 C9J7I0 UMAD1_HUMAN 85.526 0.320513 1.70803 UMAD1 - UBAP1-MVB12-associated (UMA)-domain containing protein 1 - Homo sapiens (Human) - UMAD1 gene Indicus|evm.model.CM009494.1.91 Q86VQ1 GLCI1_HUMAN 96.709 0.96798 0.74223 GLCCI1 - Glucocorticoid-induced transcript 1 protein - Homo sapiens (Human) - GLCCI1 gene cytoplasm Indicus|evm.model.CM009494.1.92 Q05084 ICA69_HUMAN 91.925 0.995842 0.995859 ICA1 - Islet cell autoantigen 1 - Homo sapiens (Human) - ICA1 gene May play a role in neurotransmitter secretion. Indicus|evm.model.CM009494.1.93 Q5E983 EF1B_BOVIN 70.755 0.983957 0.831111 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Indicus|evm.model.CM009494.1.94 Q5E9M6 NXPH1_BOVIN 100.000 0.992647 1.00369 NXPH1 - Neurexophilin-1 precursor - Bos taurus (Bovine) - NXPH1 gene May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity). Indicus|evm.model.CM009494.1.95 Q6WV74 H4_MYTCH 96.591 0.956044 0.883495 Histone H4 - Mytilus chilensis (Chilean blue mussel) Indicus|evm.model.CM009494.1.96 P08865 RSSA_HUMAN 80.952 0.613861 0.342373 RPSA - 40S ribosomal protein SA - Homo sapiens (Human) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Indicus|evm.model.CM009494.1.97 Q8N0T1 RBIS_HUMAN 83.000 0.980198 1.01 RBIS - Ribosomal biogenesis factor - Homo sapiens (Human) - RBIS gene Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production. Indicus|evm.model.CM009494.1.98 Q01321 NDUA4_BOVIN 100.000 0.975904 1.0122 NDUFA4 - Cytochrome c oxidase subunit NDUFA4 - Bos taurus (Bovine) - NDUFA4 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity). NDUFA4 is required for complex IV maintenance (By similarity). Indicus|evm.model.CM009494.1.99 O94880 PHF14_HUMAN 97.288 0.906282 1.09347 PHF14 - PHD finger protein 14 - Homo sapiens (Human) - PHF14 gene MOZ/MORF histone acetyltransferase complex, histone binding, histone H3-K14 acetylation, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009494.1.100 Q9UPZ6 THS7A_HUMAN 92.506 0.998739 0.957151 THSD7A - Thrombospondin type-1 domain-containing protein 7A precursor - Homo sapiens (Human) - THSD7A gene Plays a role in actin cytoskeleton rearrangement. Indicus|evm.model.CM009494.1.101 Q3ZC25 T106B_BOVIN 100.000 0.992754 1.00364 TMEM106B - Transmembrane protein 106B - Bos taurus (Bovine) - TMEM106B gene Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching (By similarity). Indicus|evm.model.CM009494.1.102 Q28046 ADSV_BOVIN 99.570 0.730709 0.888112 SCIN - Adseverin - Bos taurus (Bovine) - SCIN gene Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+) (PubMed:1651929, PubMed:1847925, PubMed:8780652). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (PubMed:8780652). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (By similarity). Indicus|evm.model.CM009494.1.103 P49449 CENPA_BOVIN 97.500 0.975309 0.586957 CENPA - Histone H3-like centromeric protein A - Bos taurus (Bovine) - CENPA gene Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis. Indicus|evm.model.CM009494.1.104 P61214 ARL4A_RAT 100.000 0.99005 1.005 Arl4a - ADP-ribosylation factor-like protein 4A - Rattus norvegicus (Rat) - Arl4a gene Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity). Indicus|evm.model.CM009494.1.105 P79103 RS4_BOVIN 78.469 0.994413 0.680608 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009494.1.106 Q69ZU6 THS7A_MOUSE 61.111 0.638554 0.0504559 Thsd7a - Thrombospondin type-1 domain-containing protein 7A precursor - Mus musculus (Mouse) - Thsd7a gene Plays a role in actin cytoskeleton rearrangement. Indicus|evm.model.CM009494.1.107 Q2KIC2 ETV1_BOVIN 88.477 0.995918 1.02725 ETV1 - ETS translocation variant 1 - Bos taurus (Bovine) - ETV1 gene Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. Indicus|evm.model.CM009494.1.109 Q6ZNB7 ALKMO_HUMAN 88.090 0.995516 1.00225 AGMO - Alkylglycerol monooxygenase - Homo sapiens (Human) - AGMO gene Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes. Indicus|evm.model.CM009494.1.110 P50222 MEOX2_HUMAN 98.684 0.993421 1 MEOX2 - Homeobox protein MOX-2 - Homo sapiens (Human) - MEOX2 gene Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity). Indicus|evm.model.CM009494.1.111 E1BCH6 ISPD_BOVIN 100.000 0.994832 0.869663 CRPPA - D-ribitol-5-phosphate cytidylyltransferase - Bos taurus (Bovine) - CRPPA gene Cytidylyltransferase required for protein O-linked mannosylation (By similarity). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (By similarity). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively. Not Involved in dolichol production (By similarity). Indicus|evm.model.CM009494.1.112 Q6X4U4 SOSD1_HUMAN 95.631 0.990338 1.00485 SOSTDC1 - Sclerostin domain-containing protein 1 precursor - Homo sapiens (Human) - SOSTDC1 gene May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Indicus|evm.model.CM009494.1.113 A6H759 LRC72_BOVIN 80.066 0.993333 1.04167 LRRC72 - Leucine-rich repeat-containing protein 72 - Bos taurus (Bovine) - LRRC72 gene Indicus|evm.model.CM009494.1.114 Q0VCS9 ANKY2_BOVIN 100.000 0.995485 1.00226 ANKMY2 - Ankyrin repeat and MYND domain-containing protein 2 - Bos taurus (Bovine) - ANKMY2 gene May be involved in the trafficking of signaling proteins to the cilia. Indicus|evm.model.CM009494.1.115 Q9Y6E2 BZW2_HUMAN 99.284 0.981221 1.01671 BZW2 - Basic leucine zipper and W2 domain-containing protein 2 - Homo sapiens (Human) - BZW2 gene May be involved in neuronal differentiation. Indicus|evm.model.CM009494.1.116 Q3ZBV0 TSN13_BOVIN 100.000 0.875 1.13725 TSPAN13 - Tetraspanin-13 - Bos taurus (Bovine) - TSPAN13 gene integral component of plasma membrane Indicus|evm.model.CM009494.1.117 O95994 AGR2_HUMAN 96.000 0.988636 1.00571 AGR2 - Anterior gradient protein 2 homolog precursor - Homo sapiens (Human) - AGR2 gene Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). Indicus|evm.model.CM009494.1.119 Q95LD9 AHR_DELLE 86.982 0.997633 1 AHR - Aryl hydrocarbon receptor precursor - Delphinapterus leucas (Beluga whale) - AHR gene Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer. Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists. Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands. Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription. Indicus|evm.model.CM009494.1.121 Q6PHS6 SNX13_MOUSE 89.396 0.997616 0.876698 Snx13 - Sorting nexin-13 - Mus musculus (Mouse) - Snx13 gene May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis. Indicus|evm.model.CM009494.1.124 P60892 PRPS1_RAT 90.852 0.957576 1.03774 Prps1 - Ribose-phosphate pyrophosphokinase 1 - Rattus norvegicus (Rat) - Prps1 gene Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Indicus|evm.model.CM009494.1.125 Q9UKV0 HDAC9_HUMAN 95.894 0.970043 0.693373 HDAC9 - Histone deacetylase 9 - Homo sapiens (Human) - HDAC9 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Indicus|evm.model.CM009494.1.126 Q9UKV0 HDAC9_HUMAN 95.331 0.812698 0.311573 HDAC9 - Histone deacetylase 9 - Homo sapiens (Human) - HDAC9 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Indicus|evm.model.CM009494.1.127 P26687 TWST1_MOUSE 100.000 0.978261 0.446602 Twist1 - Twist-related protein 1 - Mus musculus (Mouse) - Twist1 gene Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer. Indicus|evm.model.CM009494.1.129 Q9VGJ5 FER3_DROME 83.077 0.387879 0.846154 fer3 - Protein Fer3 - Drosophila melanogaster (Fruit fly) - fer3 gene Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity). Indicus|evm.model.CM009494.1.130 Q3B726 RPA43_HUMAN 77.246 0.984894 0.97929 POLR1F - DNA-directed RNA polymerase I subunit RPA43 - Homo sapiens (Human) - POLR1F gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters. Indicus|evm.model.CM009494.1.131 Q5RCD5 TM196_PONAB 98.883 0.583607 1.70391 TMEM196 - Transmembrane protein 196 - Pongo abelii (Sumatran orangutan) - TMEM196 gene Indicus|evm.model.CM009494.1.132 Q6ZN28 MACC1_HUMAN 74.091 0.997462 0.924883 MACC1 - Metastasis-associated in colon cancer protein 1 - Homo sapiens (Human) - MACC1 gene Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. Indicus|evm.model.CM009494.1.133 P26012 ITB8_HUMAN 91.417 0.997396 0.9987 ITGB8 - Integrin beta-8 precursor - Homo sapiens (Human) - ITGB8 gene Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072). It recognizes the sequence R-G-D in its ligands (PubMed:1918072). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity). Indicus|evm.model.CM009494.1.135 Q2M3G0 ABCB5_HUMAN 83.106 0.992889 0.894988 ABCB5 - ATP-binding cassette sub-family B member 5 - Homo sapiens (Human) - ABCB5 gene Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:22306008, PubMed:15899824, PubMed:15205344). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity). Indicus|evm.model.CM009494.1.136 Q8IXZ3 SP8_HUMAN 89.592 0.971491 0.930612 SP8 - Transcription factor Sp8 - Homo sapiens (Human) - SP8 gene Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). Indicus|evm.model.CM009494.1.137 P84246 H33_RABIT 94.118 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009494.1.138 Q02446 SP4_HUMAN 96.780 0.962003 0.73852 SP4 - Transcription factor Sp4 - Homo sapiens (Human) - SP4 gene Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Indicus|evm.model.CM009494.1.139 Q02446 SP4_HUMAN 96.610 0.848375 0.353316 SP4 - Transcription factor Sp4 - Homo sapiens (Human) - SP4 gene Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Indicus|evm.model.CM009494.1.141 Q96GN5 CDA7L_HUMAN 87.004 0.995556 0.991189 CDCA7L - Cell division cycle-associated 7-like protein - Homo sapiens (Human) - CDCA7L gene Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. Indicus|evm.model.CM009494.1.143 Q92565 RPGF5_HUMAN 87.755 0.636472 1.44655 RAPGEF5 - Rap guanine nucleotide exchange factor 5 - Homo sapiens (Human) - RAPGEF5 gene Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. Indicus|evm.model.CM009494.1.144 Q7L190 DPPA4_HUMAN 58.586 0.664384 0.480263 DPPA4 - Developmental pluripotency-associated protein 4 - Homo sapiens (Human) - DPPA4 gene May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage. Indicus|evm.model.CM009494.1.145 P26892 IL6_BOVIN 100.000 0.990431 1.00481 IL6 - Interleukin-6 precursor - Bos taurus (Bovine) - IL6 gene Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. Indicus|evm.model.CM009494.1.146 A1XQS2 TOM7_PIG 76.119 0.804878 1.49091 TOMM7 - Mitochondrial import receptor subunit TOM7 homolog - Sus scrofa (Pig) - TOMM7 gene Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity). Indicus|evm.model.CM009494.1.147 P62936 PPIA_PIG 93.902 0.987879 1.0061 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009494.1.148 Q9BYI3 HYCCI_HUMAN 87.698 0.996491 1.09405 FAM126A - Hyccin - Homo sapiens (Human) - FAM126A gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway (Probable). Indicus|evm.model.CM009494.1.149 Q8IXQ5 KLHL7_HUMAN 99.659 0.996593 1.00171 KLHL7 - Kelch-like protein 7 - Homo sapiens (Human) - KLHL7 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. Indicus|evm.model.CM009494.1.150 Q5RB98 NUP42_PONAB 77.616 0.966746 0.995272 NUP42 - Nucleoporin NUP42 - Pongo abelii (Sumatran orangutan) - NUP42 gene Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. Indicus|evm.model.CM009494.1.151 Q14956 GPNMB_HUMAN 75.176 0.989209 0.972028 GPNMB - Transmembrane glycoprotein NMB precursor - Homo sapiens (Human) - GPNMB gene Could be a melanogenic enzyme. Indicus|evm.model.CM009494.1.152 Q96EH3 MASU1_HUMAN 77.350 0.991489 1.00427 MALSU1 - Mitochondrial assembly of ribosomal large subunit protein 1 - Homo sapiens (Human) - MALSU1 gene Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable). Indicus|evm.model.CM009494.1.153 O00425 IF2B3_HUMAN 97.586 0.957025 1.04491 IGF2BP3 - Insulin-like growth factor 2 mRNA-binding protein 3 - Homo sapiens (Human) - IGF2BP3 gene RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Indicus|evm.model.CM009494.1.154 Q13595 TRA2A_HUMAN 99.645 0.992908 1 TRA2A - Transformer-2 protein homolog alpha - Homo sapiens (Human) - TRA2A gene Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Indicus|evm.model.CM009494.1.155 A2VE00 CC126_BOVIN 100.000 0.985816 1.00714 CCDC126 - Coiled-coil domain-containing protein 126 precursor - Bos taurus (Bovine) - CCDC126 gene Indicus|evm.model.CM009494.1.156 Q9UBU7 DBF4A_HUMAN 79.794 0.997037 1.00148 DBF4 - Protein DBF4 homolog A - Homo sapiens (Human) - DBF4 gene Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. Indicus|evm.model.CM009494.1.157 Q0VCH6 S2540_BOVIN 100.000 0.40176 1.00888 SLC25A40 - Solute carrier family 25 member 40 - Bos taurus (Bovine) - SLC25A40 gene Indicus|evm.model.CM009494.1.158 P08183 MDR1_HUMAN 83.523 0.612701 0.873437 ABCB1 - ATP-dependent translocase ABCB1 - Homo sapiens (Human) - ABCB1 gene Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218). Indicus|evm.model.CM009494.1.159 Q5NVC2 RUN3B_PONAB 90.789 0.995338 0.940789 RUNDC3B - RUN domain-containing protein 3B - Pongo abelii (Sumatran orangutan) - RUNDC3B gene Indicus|evm.model.CM009494.1.160 P21439 MDR3_HUMAN 86.557 0.472784 0.5 ABCB4 - Phosphatidylcholine translocator ABCB4 - Homo sapiens (Human) - ABCB4 gene Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571, PubMed:28012258). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity). Indicus|evm.model.CM009494.1.162 P08183 MDR1_HUMAN 87.575 0.980936 0.901563 ABCB1 - ATP-dependent translocase ABCB1 - Homo sapiens (Human) - ABCB1 gene Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218). Indicus|evm.model.CM009494.1.163 P21440 MDR3_MOUSE 87.432 0.998433 1 Abcb4 - Phosphatidylcholine translocator ABCB4 - Mus musculus (Mouse) - Abcb4 gene Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:8106172, PubMed:7912658, PubMed:7592705, PubMed:7814632, PubMed:8725158, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (By similarity). Required for proper phospholipid bile formation (PubMed:8106172). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:7814632, PubMed:8725158). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (PubMed:1990275). Indicus|evm.model.CM009494.1.164 O19094 OCTC_BOVIN 91.932 0.917722 0.77451 CROT - Peroxisomal carnitine O-octanoyltransferase - Bos taurus (Bovine) - CROT gene Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Indicus|evm.model.CM009494.1.165 Q3T160 NPM_BOVIN 93.750 0.854839 0.632653 NPM1 - Nucleophosmin - Bos taurus (Bovine) - NPM1 gene Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Indicus|evm.model.CM009494.1.166 P06748 NPM_HUMAN 95.385 0.761905 0.285714 NPM1 - Nucleophosmin - Homo sapiens (Human) - NPM1 gene Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). Indicus|evm.model.CM009494.1.167 A0JNK6 TM243_BOVIN 85.593 0.980392 0.864407 TMEM243 - Transmembrane protein 243 - Bos taurus (Bovine) - TMEM243 gene Indicus|evm.model.CM009494.1.168 Q9Y222 DMTF1_HUMAN 95.407 0.997375 1.00263 DMTF1 - Cyclin-D-binding Myb-like transcription factor 1 - Homo sapiens (Human) - DMTF1 gene Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. Indicus|evm.model.CM009494.1.169 Q5E9I7 MEP50_BOVIN 50.195 0.98913 0.538012 WDR77 - Methylosome protein 50 - Bos taurus (Bovine) - WDR77 gene Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Indicus|evm.model.CM009494.1.170 Q1LZG6 CCNB1_BOVIN 87.119 0.99505 0.946136 CCNB1 - G2/mitotic-specific cyclin-B1 - Bos taurus (Bovine) - CCNB1 gene Essential for the control of the cell cycle at the G2/M (mitosis) transition. Indicus|evm.model.CM009494.1.171 A7E2Z9 ELAP2_BOVIN 99.707 0.371179 0.954167 ELAPOR2 - Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 precursor - Bos taurus (Bovine) - ELAPOR2 gene Functions as a regulator of the BMP signaling pathway and may be involved in epidermal differentiation. Indicus|evm.model.CM009494.1.172 Q14832 GRM3_HUMAN 97.270 0.997727 1.00114 GRM3 - Metabotropic glutamate receptor 3 precursor - Homo sapiens (Human) - GRM3 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. Indicus|evm.model.CM009494.1.173 O15481 MAGB4_HUMAN 63.500 0.908676 0.632948 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009494.1.175 O95025 SEM3D_HUMAN 95.206 0.997337 0.966538 SEMA3D - Semaphorin-3D precursor - Homo sapiens (Human) - SEMA3D gene Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity). Indicus|evm.model.CM009494.1.176 O08665 SEM3A_MOUSE 100.000 0.986301 0.0945596 Sema3a - Semaphorin-3A precursor - Mus musculus (Mouse) - Sema3a gene Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity). Indicus|evm.model.CM009494.1.178 Q63548 SEM3A_RAT 91.486 0.994286 0.680052 Sema3a - Semaphorin-3A precursor - Rattus norvegicus (Rat) - Sema3a gene May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity). Indicus|evm.model.CM009494.1.179 O15041 SEM3E_HUMAN 88.496 0.99115 0.145806 SEMA3E - Semaphorin-3E precursor - Homo sapiens (Human) - SEMA3E gene Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity). Indicus|evm.model.CM009494.1.180 O15041 SEM3E_HUMAN 94.695 0.995192 0.805161 SEMA3E - Semaphorin-3E precursor - Homo sapiens (Human) - SEMA3E gene Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity). Indicus|evm.model.CM009494.1.181 Q9Y6V0 PCLO_HUMAN 76.335 0.984028 0.219175 PCLO - Protein piccolo - Homo sapiens (Human) - PCLO gene Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Indicus|evm.model.CM009494.1.182 Q9QYX7 PCLO_MOUSE 87.016 0.653149 0.783346 Pclo - Protein piccolo - Mus musculus (Mouse) - Pclo gene Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:19812333). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (PubMed:28231469) (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Indicus|evm.model.CM009494.1.184 P54289 CA2D1_HUMAN 90.631 0.997768 0.406165 CACNA2D1 - Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor - Homo sapiens (Human) - CACNA2D1 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). Indicus|evm.model.CM009494.1.185 Q76BS1 HGF_BOVIN 99.863 0.995896 1.00137 HGF - Hepatocyte growth factor precursor - Bos taurus (Bovine) - HGF gene Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). Indicus|evm.model.CM009494.1.186 Q5R4D4 NP1L1_PONAB 97.409 0.989691 0.496164 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Pongo abelii (Sumatran orangutan) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009494.1.187 A6H767 NP1L1_BOVIN 97.452 0.987342 0.404092 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009494.1.188 Q99880 H2B1L_HUMAN 93.651 0.984252 1.00794 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009494.1.189 P62262 1433E_SHEEP 90.000 0.450382 0.513725 YWHAE - 14-3-3 protein epsilon - Ovis aries (Sheep) - YWHAE gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Indicus|evm.model.CM009494.1.191 A7MB70 SEM3C_BOVIN 93.342 0.997151 0.934754 SEMA3C - Semaphorin-3C precursor - Bos taurus (Bovine) - SEMA3C gene Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). Indicus|evm.model.CM009494.1.192 P26201 CD36_BOVIN 69.328 0.975057 0.934322 CD36 - Platelet glycoprotein 4 - Bos taurus (Bovine) - CD36 gene Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (By similarity). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity). Involved in oral fat perception and preferences (By similarity). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome. Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity). Indicus|evm.model.CM009494.1.194 P26201 CD36_BOVIN 100.000 0.995772 1.00212 CD36 - Platelet glycoprotein 4 - Bos taurus (Bovine) - CD36 gene Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (By similarity). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity). Involved in oral fat perception and preferences (By similarity). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome. Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity). Indicus|evm.model.CM009494.1.195 P29348 GNAT3_RAT 97.436 0.130137 0.824859 Gnat3 - Guanine nucleotide-binding protein G(t) subunit alpha-3 - Rattus norvegicus (Rat) - Gnat3 gene Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications for the prevention and treatment of malabsorption syndromes and diet-related disorders including diabetes and obesity. Indicus|evm.model.CM009494.1.196 Q9WTX6 CUL1_MOUSE 78.608 0.997396 0.989691 Cul1 - Cullin-1 - Mus musculus (Mouse) - Cul1 gene Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Indicus|evm.model.CM009494.1.197 B2RSH2 GNAI1_MOUSE 100.000 0.994366 1.00282 Gnai1 - Guanine nucleotide-binding protein G(i) subunit alpha-1 - Mus musculus (Mouse) - Gnai1 gene Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis. Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Indicus|evm.model.CM009494.1.199 Q86UL8 MAGI2_HUMAN 100.000 0.847458 0.0810997 MAGI2 - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 - Homo sapiens (Human) - MAGI2 gene Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Indicus|evm.model.CM009494.1.201 Q8CB19 PHTF2_MOUSE 93.842 0.997326 1.00134 Phtf2 - Protein PHTF2 - Mus musculus (Mouse) - Phtf2 gene endoplasmic reticulum Indicus|evm.model.CM009494.1.202 Q8K174 TMM60_MOUSE 99.248 0.985075 1.00752 Tmem60 - Transmembrane protein 60 - Mus musculus (Mouse) - Tmem60 gene Indicus|evm.model.CM009494.1.203 Q6PCB5 RSBNL_HUMAN 85.950 0.997484 0.939716 RSBN1L - Lysine-specific demethylase RSBN1L - Homo sapiens (Human) - RSBN1L gene Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. Indicus|evm.model.CM009494.1.204 Q05209 PTN12_HUMAN 89.668 0.997446 1.00385 PTPN12 - Tyrosine-protein phosphatase non-receptor type 12 - Homo sapiens (Human) - PTPN12 gene Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). Indicus|evm.model.CM009494.1.205 P62936 PPIA_PIG 81.707 0.987013 0.939024 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009494.1.206 A4D1B5 GSAP_HUMAN 83.109 0.983133 0.971897 GSAP - Gamma-secretase-activating protein - Homo sapiens (Human) - GSAP gene Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. Indicus|evm.model.CM009494.1.207 Q8IYE0 CC146_HUMAN 87.971 0.99791 1.00209 CCDC146 - Coiled-coil domain-containing protein 146 - Homo sapiens (Human) - CCDC146 gene centriole, cytoskeleton Indicus|evm.model.CM009494.1.208 Q8N0U4 F185A_HUMAN 77.863 0.994819 0.984694 FAM185A - Protein FAM185A - Homo sapiens (Human) - FAM185A gene Indicus|evm.model.CM009494.1.209 Q8CDU4 DRC6_MOUSE 70.563 0.722581 0.392405 Fbxl13 - Dynein regulatory complex subunit 6 - Mus musculus (Mouse) - Fbxl13 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009494.1.210 Q8N6Y2 LRC17_HUMAN 91.837 0.995475 1.00227 LRRC17 - Leucine-rich repeat-containing protein 17 precursor - Homo sapiens (Human) - LRRC17 gene Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity). Indicus|evm.model.CM009494.1.211 Q8NEE6 DRC6_HUMAN 62.667 0.375635 0.268027 FBXL13 - Dynein regulatory complex subunit 6 - Homo sapiens (Human) - FBXL13 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009494.1.212 Q9D0L7 ARM10_MOUSE 78.878 0.974194 1.01307 Armc10 - Armadillo repeat-containing protein 10 - Mus musculus (Mouse) - Armc10 gene May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53 (By similarity). Indicus|evm.model.CM009494.1.213 Q58CN9 NAPEP_BOVIN 99.745 0.84086 1.18622 NAPEPLD - N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D - Bos taurus (Bovine) - NAPEPLD gene D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (By similarity). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity). Indicus|evm.model.CM009494.1.214 Q3SZ71 MPPB_BOVIN 99.796 0.995927 1.00204 PMPCB - Mitochondrial-processing peptidase subunit beta precursor - Bos taurus (Bovine) - PMPCB gene Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (By similarity). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (By similarity). Indicus|evm.model.CM009494.1.215 Q1RMH9 DNJC2_BOVIN 100.000 0.996785 1.00161 DNAJC2 - DnaJ homolog subfamily C member 2 - Bos taurus (Bovine) - DNAJC2 gene Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Indicus|evm.model.CM009494.1.216 Q4R4R0 PRS7_MACFA 100.000 0.995392 1.00231 PSMC2 - 26S proteasome regulatory subunit 7 - Macaca fascicularis (Crab-eating macaque) - PSMC2 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Indicus|evm.model.CM009494.1.217 P58743 S26A5_HUMAN 96.346 0.994609 0.997312 SLC26A5 - Prestin - Homo sapiens (Human) - SLC26A5 gene Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity). Indicus|evm.model.CM009494.1.219 O43913 ORC5_HUMAN 95.862 0.995413 1.0023 ORC5 - Origin recognition complex subunit 5 - Homo sapiens (Human) - ORC5 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Indicus|evm.model.CM009494.1.220 Q86UP9 LHPL3_HUMAN 99.259 0.881579 0.644068 LHFPL3 - LHFPL tetraspan subfamily member 3 protein - Homo sapiens (Human) - LHFPL3 gene membrane, plasma membrane, sensory perception of sound Indicus|evm.model.CM009494.1.221 Q86UP9 LHPL3_HUMAN 97.500 0.637097 0.525424 LHFPL3 - LHFPL tetraspan subfamily member 3 protein - Homo sapiens (Human) - LHFPL3 gene membrane, plasma membrane, sensory perception of sound Indicus|evm.model.CM009494.1.222 Q8IZD2 KMT2E_HUMAN 89.467 0.929552 0.901507 KMT2E - Inactive histone-lysine N-methyltransferase 2E - Homo sapiens (Human) - KMT2E gene Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). Indicus|evm.model.CM009494.1.223 P78362 SRPK2_HUMAN 91.099 0.997214 1.0436 SRPK2 - SRSF protein kinase 2 - Homo sapiens (Human) - SRPK2 gene Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:9472028, PubMed:18559500, PubMed:21056976). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). Indicus|evm.model.CM009494.1.224 Q08DI8 PUS7_BOVIN 99.393 0.922753 1.08042 PUS7 - Pseudouridylate synthase 7 homolog - Bos taurus (Bovine) - PUS7 gene Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types. Indicus|evm.model.CM009494.1.225 Q6NUQ1 RINT1_HUMAN 92.803 0.997478 1.00126 RINT1 - RAD50-interacting protein 1 - Homo sapiens (Human) - RINT1 gene Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870). Indicus|evm.model.CM009494.1.226 A6NFE3 EFC10_HUMAN 73.387 0.924812 1.04724 EFCAB10 - EF-hand calcium-binding domain-containing protein 10 - Homo sapiens (Human) - EFCAB10 gene Indicus|evm.model.CM009494.1.227 Q3T136 AT7L1_BOVIN 97.541 0.140861 5.92414 ATXN7L1 - Ataxin-7-like protein 1 - Bos taurus (Bovine) - ATXN7L1 gene Indicus|evm.model.CM009494.1.228 P42558 RAN_CHICK 87.742 0.980769 0.722222 RAN - GTP-binding nuclear protein Ran - Gallus gallus (Chicken) - RAN gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. Indicus|evm.model.CM009494.1.229 Q6ZTQ4 CDHR3_HUMAN 80.468 0.994179 0.970621 CDHR3 - Cadherin-related family member 3 precursor - Homo sapiens (Human) - CDHR3 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009494.1.230 Q16563 SYPL1_HUMAN 83.012 0.992218 0.992278 SYPL1 - Synaptophysin-like protein 1 - Homo sapiens (Human) - SYPL1 gene extracellular exosome, integral component of membrane, integral component of plasma membrane, synaptic vesicle membrane, syntaxin-1 binding, chemical synaptic transmission Indicus|evm.model.CM009494.1.231 Q6J1J1 BIRC5_BOVIN 82.645 0.74375 1.12676 BIRC5 - Baculoviral IAP repeat-containing protein 5 - Bos taurus (Bovine) - BIRC5 gene Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity). Indicus|evm.model.CM009494.1.232 Q52I78 NAMPT_PIG 98.574 0.995935 1.00204 NAMPT - Nicotinamide phosphoribosyltransferase - Sus scrofa (Pig) - NAMPT gene Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. Indicus|evm.model.CM009494.1.233 O02697 PK3CG_PIG 93.285 0.998106 0.958258 PIK3CG - Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform - Sus scrofa (Pig) - PIK3CG gene Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Required for B-lymphocyte development and signaling. Together with other PI3Ks are involved in the oxidative burst produced by neutrophils in response to chemotactic agents. Together with PIK3CD regulate neutrophil extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contribute to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis (By similarity). Indicus|evm.model.CM009494.1.234 P31322 KAP3_BOVIN 99.522 0.995227 1.00239 PRKAR2B - cAMP-dependent protein kinase type II-beta regulatory subunit - Bos taurus (Bovine) - PRKAR2B gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. Indicus|evm.model.CM009494.1.235 Q2KJ34 HBP1_BOVIN 100.000 0.977055 1.02148 HBP1 - HMG box-containing protein 1 - Bos taurus (Bovine) - HBP1 gene Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity). Indicus|evm.model.CM009494.1.237 O95620 DUS4L_HUMAN 91.798 0.984424 1.01262 DUS4L - tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like - Homo sapiens (Human) - DUS4L gene Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Indicus|evm.model.CM009494.1.238 Q32KL9 BAP29_BOVIN 100.000 0.991701 1.00417 BCAP29 - B-cell receptor-associated protein 29 - Bos taurus (Bovine) - BCAP29 gene May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity). Indicus|evm.model.CM009494.1.239 O43511 S26A4_HUMAN 88.630 0.941535 1.05256 SLC26A4 - Pendrin - Homo sapiens (Human) - SLC26A4 gene Sodium-independent transporter of chloride and iodide. Indicus|evm.model.CM009494.1.240 Q75N03 HAKAI_HUMAN 97.764 0.995943 1.00407 CBLL1 - E3 ubiquitin-protein ligase Hakai - Homo sapiens (Human) - CBLL1 gene E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). Indicus|evm.model.CM009494.1.241 Q924C9 S26A3_RAT 84.079 0.997372 1.00528 Slc26a3 - Chloride anion exchanger - Rattus norvegicus (Rat) - Slc26a3 gene Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity). Indicus|evm.model.CM009494.1.242 P49819 DLDH_CANLF 97.839 0.996078 1.00196 DLD - Dihydrolipoyl dehydrogenase, mitochondrial precursor - Canis lupus familiaris (Dog) - DLD gene Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). Indicus|evm.model.CM009494.1.243 Q01635 LAMB1_CHICK 92.079 0.174365 5.71617 LAMB1 - Laminin subunit beta-1 - Gallus gallus (Chicken) - LAMB1 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Indicus|evm.model.CM009494.1.244 A4D0S4 LAMB4_HUMAN 86.364 0.133089 0.465077 LAMB4 - Laminin subunit beta-4 precursor - Homo sapiens (Human) - LAMB4 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Indicus|evm.model.CM009494.1.245 Q92823 NRCAM_HUMAN 93.427 0.877888 0.929448 NRCAM - Neuronal cell adhesion molecule precursor - Homo sapiens (Human) - NRCAM gene Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. Indicus|evm.model.CM009494.1.247 Q9NP80 PLPL8_HUMAN 89.041 0.993179 0.93734 PNPLA8 - Calcium-independent phospholipase A2-gamma - Homo sapiens (Human) - PNPLA8 gene Calcium-independent phospholipase A2, which promotes cellular membrane hydrolysis and prostaglandin production (PubMed:10744668, PubMed:15695510). Catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, phosphytidylserine and to a lower extent phosphatidylcholine (PubMed:10744668). Cleaves membrane phospholipids (PubMed:15695510). Participates in the generation of lipid second messengers through the mobilization of arachidonic acid in response to cellular stimuli. Synthesizes 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling (PubMed:15908428). Participates in the lipid plasticity of myocardium, plays a role in the generation of signaling metabolites and has a prominent effect on the modulaton of energy storage and utilization (PubMed:17213206). Essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition (By similarity). Indicus|evm.model.CM009494.1.249 Q8N427 TXND3_HUMAN 69.007 0.981324 1.0017 NME8 - Thioredoxin domain-containing protein 3 - Homo sapiens (Human) - NME8 gene Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. Indicus|evm.model.CM009494.1.250 Q6FHJ7 SFRP4_HUMAN 91.908 0.993976 0.959538 SFRP4 - Secreted frizzled-related protein 4 precursor - Homo sapiens (Human) - SFRP4 gene Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927). Indicus|evm.model.CM009494.1.251 A6QLI0 EPDR1_BOVIN 99.576 0.991561 1.00424 EPDR1 - Mammalian ependymin-related protein 1 precursor - Bos taurus (Bovine) - EPDR1 gene Binds anionic lipids and gangliosides at acidic pH. Indicus|evm.model.CM009494.1.252 O95772 STR3N_HUMAN 97.021 0.991525 1.00855 STARD3NL - STARD3 N-terminal-like protein - Homo sapiens (Human) - STARD3NL gene Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). Indicus|evm.model.CM009494.1.253 P03986 TRGC2_HUMAN 55.122 0.927273 1.16402 TRGC2 - T cell receptor gamma constant 2 - Homo sapiens (Human) - TRGC2 gene Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009494.1.255 P01853 TCC1_MOUSE 64.035 0.573604 1.17964 T-cell receptor gamma chain C region C10.5 - Mus musculus (Mouse) Indicus|evm.model.CM009494.1.256 Q09YI1 CTTB2_SHEEP 97.564 0.998783 1.00122 CTTNBP2 - Cortactin-binding protein 2 - Ovis aries (Sheep) - CTTNBP2 gene Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance. Indicus|evm.model.CM009494.1.257 P35071 CFTR_BOVIN 93.443 0.976579 0.951384 CFTR - Cystic fibrosis transmembrane conductance regulator - Bos taurus (Bovine) - CFTR gene Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity). Indicus|evm.model.CM009494.1.258 Q8WMX8 ASZ1_BOVIN 100.000 0.995798 1.00211 ASZ1 - Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 - Bos taurus (Bovine) - ASZ1 gene Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). Indicus|evm.model.CM009494.1.259 Q09YI4 WNT2_SHEEP 100.000 0.993976 0.922222 WNT2 - Protein Wnt-2 precursor - Ovis aries (Sheep) - WNT2 gene Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). Indicus|evm.model.CM009494.1.260 Q2PG42 ST7_MACFA 100.000 0.996262 1.00187 ST7 - Suppressor of tumorigenicity 7 protein - Macaca fascicularis (Crab-eating macaque) - ST7 gene Indicus|evm.model.CM009494.1.261 Q09YJ9 CAZA2_MUNMU 92.657 0.992481 0.93007 CAPZA2 - F-actin-capping protein subunit alpha-2 - Muntiacus muntjak (Barking deer) - CAPZA2 gene F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). Indicus|evm.model.CM009494.1.262 Q769I5 MET_BOVIN 99.633 0.669951 0.880058 MET - Hepatocyte growth factor receptor precursor - Bos taurus (Bovine) - MET gene Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity). Indicus|evm.model.CM009494.1.263 Q6B3Y2 CAV1_SHEEP 100.000 0.988827 1.00562 CAV1 - Caveolin-1 - Ovis aries (Sheep) - CAV1 gene May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity). Indicus|evm.model.CM009494.1.264 Q66WT7 CAV2_BOVIN 100.000 0.98773 1.00617 CAV2 - Caveolin-2 - Bos taurus (Bovine) - CAV2 gene May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). Indicus|evm.model.CM009494.1.265 Q2YDE9 TES_BOVIN 100.000 0.995157 0.980998 TES - Testin - Bos taurus (Bovine) - TES gene Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity). Indicus|evm.model.CM009494.1.266 A4IFU7 TFEC_BOVIN 99.685 0.993711 1.00315 TFEC - Transcription factor EC - Bos taurus (Bovine) - TFEC gene Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Binds DNA in a homo- or heterodimeric form (By similarity). Indicus|evm.model.CM009494.1.267 Q9P1T7 MDFIC_HUMAN 89.024 0.785016 1.24797 MDFIC - MyoD family inhibitor domain-containing protein - Homo sapiens (Human) - MDFIC gene Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. Indicus|evm.model.CM009494.1.269 Q8MJ99 FOXP2_GORGO 85.185 0.996522 0.806452 FOXP2 - Forkhead box protein P2 - Gorilla gorilla gorilla (Western lowland gorilla) - FOXP2 gene Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). Indicus|evm.model.CM009494.1.270 Q8MJA0 FOXP2_PANTR 96.667 0.794643 0.156425 FOXP2 - Forkhead box protein P2 - Pan troglodytes (Chimpanzee) - FOXP2 gene Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). Indicus|evm.model.CM009494.1.271 Q00756 PPR3A_RABIT 81.923 0.245964 0.949504 PPP1R3A - Protein phosphatase 1 regulatory subunit 3A - Oryctolagus cuniculus (Rabbit) - PPP1R3A gene Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). Indicus|evm.model.CM009494.1.274 P60895 GPR85_RAT 99.730 0.994609 1.0027 Gpr85 - Probable G-protein coupled receptor 85 - Rattus norvegicus (Rat) - Gpr85 gene Orphan receptor. Indicus|evm.model.CM009494.1.275 A5PK14 LSME1_BOVIN 99.219 0.984496 1.00781 LSMEM1 - Leucine-rich single-pass membrane protein 1 - Bos taurus (Bovine) - LSMEM1 gene Indicus|evm.model.CM009494.1.276 Q5S1U6 IFRD1_PIG 96.889 0.995565 1.00222 IFRD1 - Interferon-related developmental regulator 1 - Sus scrofa (Pig) - IFRD1 gene Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity). Indicus|evm.model.CM009494.1.277 Q9NRM2 ZN277_HUMAN 83.778 0.924945 1.00667 ZNF277 - Zinc finger protein 277 - Homo sapiens (Human) - ZNF277 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009494.1.278 Q1RMZ1 SAMTR_HUMAN 96.296 0.995074 1.00247 BMT2 - S-adenosylmethionine sensor upstream of mTORC1 - Homo sapiens (Human) - BMT2 gene S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). Indicus|evm.model.CM009494.1.279 A0JNG0 TM168_BOVIN 100.000 0.997135 1.00143 TMEM168 - Transmembrane protein 168 - Bos taurus (Bovine) - TMEM168 gene Indicus|evm.model.CM009494.1.280 Q4R8N7 STIP1_MACFA 50.204 0.741818 0.506446 STIP1 - Stress-induced-phosphoprotein 1 - Macaca fascicularis (Crab-eating macaque) - STIP1 gene Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Indicus|evm.model.CM009494.1.281 Q8N1I0 DOCK4_HUMAN 88.718 0.998689 0.776195 DOCK4 - Dedicator of cytokinesis protein 4 - Homo sapiens (Human) - DOCK4 gene Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). Indicus|evm.model.CM009494.1.282 Q8VH49 HIG1A_RAT 83.871 0.978723 1.01075 Higd1a - HIG1 domain family member 1A, mitochondrial - Rattus norvegicus (Rat) - Higd1a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Indicus|evm.model.CM009494.1.283 Q9H3W5 LRRN3_HUMAN 92.938 0.997179 1.00141 LRRN3 - Leucine-rich repeat neuronal protein 3 precursor - Homo sapiens (Human) - LRRN3 gene extracellular matrix, extracellular space Indicus|evm.model.CM009494.1.284 Q0P5H5 RGS2_BOVIN 100.000 0.988889 0.853081 RGS2 - Regulator of G-protein signaling 2 - Bos taurus (Bovine) - RGS2 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity). Indicus|evm.model.CM009494.1.286 Q9UPT8 ZC3H4_HUMAN 55.102 0.607595 0.0606293 ZC3H4 - Zinc finger CCCH domain-containing protein 4 - Homo sapiens (Human) - ZC3H4 gene cytosol, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA binding Indicus|evm.model.CM009494.1.287 Q7YRC1 AIP_BOVIN 54.749 0.952381 0.381818 AIP - AH receptor-interacting protein - Bos taurus (Bovine) - AIP gene May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Indicus|evm.model.CM009494.1.288 Q9QYI6 DNJB9_MOUSE 94.619 0.944681 1.05856 Dnajb9 - DnaJ homolog subfamily B member 9 precursor - Mus musculus (Mouse) - Dnajb9 gene Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:11836248). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:22267725). Required for survival of B-cell progenitors and normal antibody production (PubMed:25222125). Indicus|evm.model.CM009494.1.290 Q1RMM0 THAP5_BOVIN 99.747 0.994949 1.00508 THAP5 - THAP domain-containing protein 5 - Bos taurus (Bovine) - THAP5 gene Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase. Indicus|evm.model.CM009494.1.291 Q86W50 MET16_HUMAN 76.289 0.96 0.177936 METTL16 - RNA N6-adenosine-methyltransferase METTL16 - Homo sapiens (Human) - METTL16 gene RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). Indicus|evm.model.CM009494.1.292 Q7Z602 GP141_HUMAN 80.328 0.993421 0.996721 GPR141 - Probable G-protein coupled receptor 141 - Homo sapiens (Human) - GPR141 gene Orphan receptor. Indicus|evm.model.CM009494.1.293 Q92556 ELMO1_HUMAN 99.587 0.997253 1.00138 ELMO1 - Engulfment and cell motility protein 1 - Homo sapiens (Human) - ELMO1 gene Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Indicus|evm.model.CM009494.1.294 P62083 RS7_RAT 76.159 0.986755 0.778351 Rps7 - 40S ribosomal protein S7 - Rattus norvegicus (Rat) - Rps7 gene Required for rRNA maturation. Indicus|evm.model.CM009494.1.295 P28039 AOAH_HUMAN 80.696 0.996528 1.00174 AOAH - Acyloxyacyl hydrolase precursor - Homo sapiens (Human) - AOAH gene Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145, PubMed:29343645). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity). Indicus|evm.model.CM009494.1.296 Q9NQW6 ANLN_HUMAN 86.421 0.998197 0.986655 ANLN - Anillin - Homo sapiens (Human) - ANLN gene Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). Indicus|evm.model.CM009494.1.297 Q7TQE7 K0895_MOUSE 85.277 0.994286 1.01156 Kiaa0895 - Uncharacterized protein KIAA0895 - Mus musculus (Mouse) - Kiaa0895 gene Indicus|evm.model.CM009494.1.298 Q3MHJ7 EEPD1_BOVIN 100.000 0.996503 1.00175 EEPD1 - Endonuclease/exonuclease/phosphatase family domain-containing protein 1 - Bos taurus (Bovine) - EEPD1 gene Indicus|evm.model.CM009494.1.300 Q5R481 SEPT7_PONAB 100.000 0.995434 1.00229 SEPTIN7 - Septin-7 - Pongo abelii (Sumatran orangutan) - SEPTIN7 gene Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Indicus|evm.model.CM009494.1.302 Q0P5H8 HERP2_BOVIN 100.000 0.995086 1.00246 HERPUD2 - Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein - Bos taurus (Bovine) - HERPUD2 gene Could be involved in the unfolded protein response (UPR) pathway. Indicus|evm.model.CM009494.1.303 P62878 RBX1_MOUSE 97.115 0.980952 0.972222 Rbx1 - E3 ubiquitin-protein ligase RBX1 - Mus musculus (Mouse) - Rbx1 gene E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:22118460). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components (By similarity). As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate (By similarity). Probably also stimulates CDC34 autoubiquitination (By similarity). May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair (By similarity). Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity). Indicus|evm.model.CM009494.1.305 Q9UMR3 TBX20_HUMAN 98.441 0.995556 1.00671 TBX20 - T-box transcription factor TBX20 - Homo sapiens (Human) - TBX20 gene Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart. Indicus|evm.model.CM009494.1.306 Q6NUT2 D19L2_HUMAN 82.378 0.922481 1.02111 DPY19L2 - Probable C-mannosyltransferase DPY19L2 - Homo sapiens (Human) - DPY19L2 gene Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation. Indicus|evm.model.CM009494.1.307 Q2PZI1 D19L1_HUMAN 96.278 0.996769 0.917037 DPY19L1 - Probable C-mannosyltransferase DPY19L1 - Homo sapiens (Human) - DPY19L1 gene Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Indicus|evm.model.CM009494.1.308 Q56H79 NPSR1_MACMU 91.815 0.949153 0.795148 NPSR1 - Neuropeptide S receptor - Macaca mulatta (Rhesus macaque) - NPSR1 gene G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. Indicus|evm.model.CM009494.1.309 Q8N8U9 BMPER_HUMAN 94.599 0.997085 1.00146 BMPER - BMP-binding endothelial regulator protein precursor - Homo sapiens (Human) - BMPER gene Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. Indicus|evm.model.CM009494.1.310 Q3SYG4 PTHB1_HUMAN 90.663 0.997297 0.834273 BBS9 - Protein PTHB1 - Homo sapiens (Human) - BBS9 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization. Indicus|evm.model.CM009494.1.311 P97762 RP9_MOUSE 97.163 0.679612 0.967136 rp9 - Retinitis pigmentosa 9 protein homolog - Mus musculus (Mouse) - rp9 gene Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1. Indicus|evm.model.CM009494.1.313 Q9H0P0 5NT3A_HUMAN 92.145 0.993976 0.988095 NT5C3A - Cytosolic 5'-nucleotidase 3A - Homo sapiens (Human) - NT5C3A gene Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458). Indicus|evm.model.CM009494.1.314 Q2KJC8 FKBP9_BOVIN 100.000 0.996522 1.00174 FKBP9 - Peptidyl-prolyl cis-trans isomerase FKBP9 precursor - Bos taurus (Bovine) - FKBP9 gene PPIases accelerate the folding of proteins during protein synthesis. Indicus|evm.model.CM009494.1.316 Q8IY47 KBTB2_HUMAN 97.913 0.996795 1.00161 KBTBD2 - Kelch repeat and BTB domain-containing protein 2 - Homo sapiens (Human) - KBTBD2 gene Indicus|evm.model.CM009494.1.317 Q8NBF6 AVL9_HUMAN 92.892 0.958075 0.993827 AVL9 - Late secretory pathway protein AVL9 homolog - Homo sapiens (Human) - AVL9 gene Functions in cell migration. Indicus|evm.model.CM009494.1.318 Q5R628 LSM5_PONAB 93.548 0.743902 0.901099 LSM5 - U6 snRNA-associated Sm-like protein LSm5 - Pongo abelii (Sumatran orangutan) - LSM5 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Indicus|evm.model.CM009494.1.323 Q63421 PDE1C_RAT 89.157 0.386792 0.276042 Pde1c - Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C - Rattus norvegicus (Rat) - Pde1c gene Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP (PubMed:7568196). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (By similarity). Indicus|evm.model.CM009494.1.324 Q14123 PDE1C_HUMAN 95.270 0.98995 0.842031 PDE1C - Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C - Homo sapiens (Human) - PDE1C gene Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8557689, PubMed:29860631). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). Indicus|evm.model.CM009494.1.325 O96001 PPR17_HUMAN 92.258 0.987179 1.00645 PPP1R17 - Protein phosphatase 1 regulatory subunit 17 - Homo sapiens (Human) - PPP1R17 gene Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes. Indicus|evm.model.CM009494.1.326 Q14B48 ITPI1_MOUSE 66.486 0.190476 0.77176 Itprid1 - Protein ITPRID1 - Mus musculus (Mouse) - Itprid1 gene Indicus|evm.model.CM009494.1.327 Q08DI0 NDF6_BOVIN 100.000 0.994083 1.00297 NEUROD6 - Neurogenic differentiation factor 6 - Bos taurus (Bovine) - NEUROD6 gene Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity). Indicus|evm.model.CM009494.1.328 Q29627 PACR_BOVIN 99.805 0.996109 1.00195 ADCYAP1R1 - Pituitary adenylate cyclase-activating polypeptide type I receptor precursor - Bos taurus (Bovine) - ADCYAP1R1 gene This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (By similarity). Indicus|evm.model.CM009494.1.329 P34999 GHRHR_PIG 87.441 0.956818 1.04019 GHRHR - Growth hormone-releasing hormone receptor precursor - Sus scrofa (Pig) - GHRHR gene Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Indicus|evm.model.CM009494.1.330 P47865 AQP1_BOVIN 100.000 0.992647 1.00369 AQP1 - Aquaporin-1 - Bos taurus (Bovine) - AQP1 gene Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Indicus|evm.model.CM009494.1.331 A1A4L4 MINY4_BOVIN 99.607 0.997382 1.00131 MINDY4 - Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 - Bos taurus (Bovine) - MINDY4 gene Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Indicus|evm.model.CM009494.1.332 P40936 INMT_MOUSE 68.561 0.992424 1 Inmt - Indolethylamine N-methyltransferase - Mus musculus (Mouse) - Inmt gene Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. Indicus|evm.model.CM009494.1.333 Q13324 CRFR2_HUMAN 95.767 0.8627 1.06326 CRHR2 - Corticotropin-releasing factor receptor 2 - Homo sapiens (Human) - CRHR2 gene G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Indicus|evm.model.CM009494.1.334 Q5RBL1 GARS_PONAB 86.728 0.997253 0.985115 GARS1 - Glycine--tRNA ligase precursor - Pongo abelii (Sumatran orangutan) - GARS1 gene Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Indicus|evm.model.CM009494.1.335 Q32LE4 GGCT_BOVIN 100.000 0.989418 1.00532 GGCT - Gamma-glutamylcyclotransferase - Bos taurus (Bovine) - GGCT gene Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Indicus|evm.model.CM009494.1.336 Q9Y239 NOD1_HUMAN 83.229 0.997906 1.0021 NOD1 - Nucleotide-binding oligomerization domain-containing protein 1 - Homo sapiens (Human) - NOD1 gene Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection. Indicus|evm.model.CM009494.1.337 Q8NHG8 ZNRF2_HUMAN 85.714 0.314721 0.81405 ZNRF2 - E3 ubiquitin-protein ligase ZNRF2 - Homo sapiens (Human) - ZNRF2 gene May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Indicus|evm.model.CM009494.1.339 Q8N3F0 MTURN_HUMAN 100.000 0.984848 1.00763 MTURN - Maturin - Homo sapiens (Human) - MTURN gene Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser-536' (PubMed:24681962). May be involved in early neuronal development (By similarity). Indicus|evm.model.CM009494.1.340 F1MS15 PKHA8_BOVIN 100.000 0.996161 1.00192 PLEKHA8 - Pleckstrin homology domain-containing family A member 8 - Bos taurus (Bovine) - PLEKHA8 gene Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity). Indicus|evm.model.CM009494.1.341 Q5R941 FKB14_PONAB 96.682 0.990566 1.00474 FKBP14 - Peptidyl-prolyl cis-trans isomerase FKBP14 precursor - Pongo abelii (Sumatran orangutan) - FKBP14 gene PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens. Indicus|evm.model.CM009494.1.342 P83939 SCRN1_BOVIN 99.758 0.995181 1.00242 SCRN1 - Secernin-1 - Bos taurus (Bovine) - SCRN1 gene Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium. Indicus|evm.model.CM009494.1.343 A6NGB9 WIPF3_HUMAN 89.474 0.3159 0.989648 WIPF3 - WAS/WASL-interacting protein family member 3 - Homo sapiens (Human) - WIPF3 gene May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity). Indicus|evm.model.CM009494.1.344 Q8IV56 PRR15_HUMAN 79.070 0.984252 0.984496 PRR15 - Proline-rich protein 15 - Homo sapiens (Human) - PRR15 gene May have a role in proliferation and/or differentiation. Indicus|evm.model.CM009494.1.345 Q1JQC1 MFSD1_BOVIN 52.055 0.418301 0.326923 MFSD1 - Major facilitator superfamily domain-containing protein 1 - Bos taurus (Bovine) - MFSD1 gene Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP. Indicus|evm.model.CM009494.1.346 Q80XD1 CHIO_MOUSE 98.917 0.588486 1.41265 Chn2 - Beta-chimaerin - Mus musculus (Mouse) - Chn2 gene GTPase-activating protein for p21-rac. Indicus|evm.model.CM009494.1.347 Q9H3G5 CPVL_HUMAN 65.116 0.995192 0.87395 CPVL - Probable serine carboxypeptidase CPVL precursor - Homo sapiens (Human) - CPVL gene May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. Indicus|evm.model.CM009494.1.348 Q7L0X0 TRIL_HUMAN 90.271 0.997534 1 TRIL - TLR4 interactor with leucine rich repeats precursor - Homo sapiens (Human) - TRIL gene Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion. Indicus|evm.model.CM009494.1.350 Q02930 CREB5_HUMAN 97.206 0.996016 0.988189 CREB5 - Cyclic AMP-responsive element-binding protein 5 - Homo sapiens (Human) - CREB5 gene Binds to the cAMP response element and activates transcription. Indicus|evm.model.CM009494.1.351 Q5RDF5 JAZF1_PONAB 100.000 0.991803 1.00412 JAZF1 - Juxtaposed with another zinc finger protein 1 - Pongo abelii (Sumatran orangutan) - JAZF1 gene Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity. Indicus|evm.model.CM009494.1.352 Q2KJE0 TAXB1_BOVIN 100.000 0.997555 1.00122 TAX1BP1 - Tax1-binding protein 1 homolog - Bos taurus (Bovine) - TAX1BP1 gene Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity). Indicus|evm.model.CM009494.1.355 Q2HJD7 3HIDH_BOVIN 100.000 0.994065 1.00298 HIBADH - 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - HIBADH gene mitochondrion, 3-hydroxyisobutyrate dehydrogenase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, valine catabolic process Indicus|evm.model.CM009494.1.357 P49640 EVX1_HUMAN 93.366 0.995062 0.995086 EVX1 - Homeobox even-skipped homolog protein 1 - Homo sapiens (Human) - EVX1 gene May play a role in the specification of neuronal cell types. Indicus|evm.model.CM009494.1.358 P31271 HXA13_HUMAN 99.024 0.990291 0.530928 HOXA13 - Homeobox protein Hox-A13 - Homo sapiens (Human) - HOXA13 gene Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009494.1.360 P31258 HXA11_CHICK 96.429 0.30292 0.922559 HOXA11 - Homeobox protein Hox-A11 - Gallus gallus (Chicken) - HOXA11 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009494.1.361 P31260 HXA10_HUMAN 84.726 0.995238 1.02439 HOXA10 - Homeobox protein Hox-A10 - Homo sapiens (Human) - HOXA10 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. Indicus|evm.model.CM009494.1.362 P09631 HXA9_MOUSE 98.162 0.992674 1.00738 Hoxa9 - Homeobox protein Hox-A9 - Mus musculus (Mouse) - Hoxa9 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Indicus|evm.model.CM009494.1.363 P31268 HXA7_HUMAN 95.050 0.841004 1.03913 HOXA7 - Homeobox protein Hox-A7 - Homo sapiens (Human) - HOXA7 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009494.1.364 P20719 HXA5_HUMAN 99.130 0.351852 1.2 HOXA5 - Homeobox protein Hox-A5 - Homo sapiens (Human) - HOXA5 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. Indicus|evm.model.CM009494.1.365 Q00056 HXA4_HUMAN 95.935 0.685393 0.55625 HOXA4 - Homeobox protein Hox-A4 - Homo sapiens (Human) - HOXA4 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'. Indicus|evm.model.CM009494.1.366 Q08DG7 HXA3_BOVIN 100.000 0.995485 1.00226 HOXA3 - Homeobox protein Hox-A3 - Bos taurus (Bovine) - HOXA3 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009494.1.367 Q0VCS4 HXA2_BOVIN 99.731 0.994638 1.00269 HOXA2 - Homeobox protein Hox-A2 - Bos taurus (Bovine) - HOXA2 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009494.1.368 P49639 HXA1_HUMAN 93.092 0.901198 0.997015 HOXA1 - Homeobox protein Hox-A1 - Homo sapiens (Human) - HOXA1 gene Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity). Indicus|evm.model.CM009494.1.369 Q32LP7 SKAP2_BOVIN 99.721 0.994429 1.00279 SKAP2 - Src kinase-associated phosphoprotein 2 - Bos taurus (Bovine) - SKAP2 gene May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity). Indicus|evm.model.CM009494.1.370 Q0IIL5 SNX10_BOVIN 100.000 0.99005 1.005 SNX10 - Sorting nexin-10 - Bos taurus (Bovine) - SNX10 gene Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption (By similarity). Indicus|evm.model.CM009494.1.371 Q5R6X7 CBX3_PONAB 100.000 0.877193 0.622951 CBX3 - Chromobox protein homolog 3 - Pongo abelii (Sumatran orangutan) - CBX3 gene Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). Indicus|evm.model.CM009494.1.372 P22626 ROA2_HUMAN 100.000 0.99435 1.00283 HNRNPA2B1 - Heterogeneous nuclear ribonucleoproteins A2/B1 - Homo sapiens (Human) - HNRNPA2B1 gene Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays also a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). Indicus|evm.model.CM009494.1.374 Q9Y4A8 NF2L3_HUMAN 78.998 0.668301 0.881844 NFE2L3 - Nuclear factor erythroid 2-related factor 3 - Homo sapiens (Human) - NFE2L3 gene Activates erythroid-specific, globin gene expression. Indicus|evm.model.CM009494.1.375 Q9C075 K1C23_HUMAN 47.826 0.73262 0.443128 KRT23 - Keratin, type I cytoskeletal 23 - Homo sapiens (Human) - KRT23 gene cytosol, cornification, keratinization Indicus|evm.model.CM009494.1.376 Q9GM96 NPVF_BOVIN 92.708 0.82684 1.17857 NPVF - Pro-FMRFamide-related neuropeptide VF precursor - Bos taurus (Bovine) - NPVF gene Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptide NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide NPVF blocks morphine-induced analgesia (By similarity). Indicus|evm.model.CM009494.1.378 Q8N865 CG031_HUMAN 82.881 0.996581 0.991525 C7orf31 - Uncharacterized protein C7orf31 - Homo sapiens (Human) - C7orf31 gene centrosome Indicus|evm.model.CM009494.1.379 P62896 CYC_SHEEP 100.000 0.981132 1.00952 CYCS - Cytochrome c - Ovis aries (Sheep) - CYCS gene Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Indicus|evm.model.CM009494.1.380 Q9H4L5 OSBL3_HUMAN 93.341 0.997745 1 OSBPL3 - Oxysterol-binding protein-related protein 3 - Homo sapiens (Human) - OSBPL3 gene Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). Indicus|evm.model.CM009494.1.381 Q5RDL6 EID1_PONAB 84.293 0.989583 1.02128 EID1 - EP300-interacting inhibitor of differentiation 1 - Pongo abelii (Sumatran orangutan) - EID1 gene Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms (By similarity). Indicus|evm.model.CM009494.1.382 Q7YS54 GSDME_HORSE 88.806 0.320482 0.83501 GSDME - Gasdermin-E - Equus caballus (Horse) - GSDME gene Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis. Indicus|evm.model.CM009494.1.384 Q9NZW5 MPP6_HUMAN 98.889 0.942308 1.05926 PALS2 - Protein PALS2 - Homo sapiens (Human) - PALS2 gene extracellular exosome, membrane, protein-containing complex assembly Indicus|evm.model.CM009494.1.385 Q6RUW3 NPY_BOVIN 97.826 0.957895 0.979381 NPY - Pro-neuropeptide Y precursor - Bos taurus (Bovine) - NPY gene NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Indicus|evm.model.CM009494.1.386 Q9BXU1 STK31_HUMAN 83.694 0.998037 1 STK31 - Serine/threonine-protein kinase 31 - Homo sapiens (Human) - STK31 gene cytoplasm, nucleus, nuclease activity Indicus|evm.model.CM009494.1.387 A4D161 F221A_HUMAN 89.597 0.993289 1 FAM221A - Protein FAM221A - Homo sapiens (Human) - FAM221A gene Indicus|evm.model.CM009494.1.388 Q9P0K1 ADA22_HUMAN 80.488 0.771429 0.115894 ADAM22 - Disintegrin and metalloproteinase domain-containing protein 22 precursor - Homo sapiens (Human) - ADAM22 gene Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. Indicus|evm.model.CM009494.1.389 Q9D0B5 TSTD3_MOUSE 81.818 0.960784 0.649682 Tstd3 - Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3 - Mus musculus (Mouse) - Tstd3 gene Indicus|evm.model.CM009494.1.390 Q9P0K1 ADA22_HUMAN 90.297 0.967532 0.679912 ADAM22 - Disintegrin and metalloproteinase domain-containing protein 22 precursor - Homo sapiens (Human) - ADAM22 gene Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. Indicus|evm.model.CM009494.1.391 Q5R4U9 SORCN_PONAB 98.990 0.98995 1.00505 SRI - Sorcin - Pongo abelii (Sumatran orangutan) - SRI gene Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels (By similarity). Indicus|evm.model.CM009494.1.392 Q687X5 STEA4_HUMAN 86.492 0.972399 1.02614 STEAP4 - Metalloreductase STEAP4 - Homo sapiens (Human) - STEAP4 gene Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193). Indicus|evm.model.CM009494.1.394 Q8TBZ9 TEX47_HUMAN 77.075 0.992095 1 TEX47 - Testis-expressed protein 47 - Homo sapiens (Human) - TEX47 gene Indicus|evm.model.CM009494.1.396 A4D1E1 Z804B_HUMAN 95.833 0.494737 0.0704225 ZNF804B - Zinc finger protein 804B - Homo sapiens (Human) - ZNF804B gene nucleus Indicus|evm.model.CM009494.1.397 A4D1E1 Z804B_HUMAN 73.875 0.996845 0.939956 ZNF804B - Zinc finger protein 804B - Homo sapiens (Human) - ZNF804B gene nucleus Indicus|evm.model.CM009494.1.399 Q9GL50 STEA1_PIG 92.330 0.994118 1.00592 STEAP1 - Metalloreductase STEAP1 - Sus scrofa (Pig) - STEAP1 gene Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Indicus|evm.model.CM009494.1.400 Q8NFT2 STEA2_HUMAN 97.551 0.995927 1.00204 STEAP2 - Metalloreductase STEAP2 - Homo sapiens (Human) - STEAP2 gene Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). Indicus|evm.model.CM009494.1.401 B0CM26 CFA69_PAPAN 86.530 0.984076 1.00106 CFAP69 - Cilia- and flagella-associated protein 69 - Papio anubis (Olive baboon) - CFAP69 gene Cilium- and flagellum-associated protein (By similarity). In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability (By similarity). Indicus|evm.model.CM009494.1.402 Q3MHG6 GTPBA_BOVIN 99.483 0.994845 1.00258 GTPBP10 - GTP-binding protein 10 - Bos taurus (Bovine) - GTPBP10 gene May be involved in the ribosome maturation process. Indicus|evm.model.CM009494.1.403 O60921 HUS1_HUMAN 91.786 0.992883 1.00357 HUS1 - Checkpoint protein HUS1 - Homo sapiens (Human) - HUS1 gene Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Indicus|evm.model.CM009494.1.405 Q68CZ2 TENS3_HUMAN 81.474 0.899749 1.1045 TNS3 - Tensin-3 - Homo sapiens (Human) - TNS3 gene May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity). Indicus|evm.model.CM009494.1.407 Q8IVM0 CCD50_HUMAN 89.706 0.634615 0.339869 CCDC50 - Coiled-coil domain-containing protein 50 - Homo sapiens (Human) - CCDC50 gene Involved in EGFR signaling. Indicus|evm.model.CM009494.1.408 P20959 IBP3_BOVIN 100.000 0.993151 1.00344 IGFBP3 - Insulin-like growth factor-binding protein 3 precursor - Bos taurus (Bovine) - IGFBP3 gene IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Indicus|evm.model.CM009494.1.409 P24591 IBP1_BOVIN 100.000 0.992424 1.0038 IGFBP1 - Insulin-like growth factor-binding protein 1 precursor - Bos taurus (Bovine) - IGFBP1 gene IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity). Indicus|evm.model.CM009494.1.410 P19754 ADCY1_BOVIN 97.748 0.985778 0.992063 ADCY1 - Adenylate cyclase type 1 - Bos taurus (Bovine) - ADCY1 gene Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:2472670, PubMed:2022671. PubMed:19029295). Mediates responses to increased cellular Ca(2+)/calmodulin levels (PubMed:2022671, PubMed:19029295). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). Indicus|evm.model.CM009494.1.411 Q7YS88 RAMP3_PIG 81.208 0.980132 1 RAMP3 - Receptor activity-modifying protein 3 precursor - Sus scrofa (Pig) - RAMP3 gene Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). Indicus|evm.model.CM009494.1.412 Q3SZK4 FAKD4_BOVIN 100.000 0.986 0.791139 TBRG4 - FAST kinase domain-containing protein 4 precursor - Bos taurus (Bovine) - TBRG4 gene Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression. Indicus|evm.model.CM009494.1.413 Q6IP73 NACA_XENLA 72.222 0.0608466 12.4225 naca - Nascent polypeptide-associated complex subunit alpha - Xenopus laevis (African clawed frog) - naca gene May promote appropriate targeting of ribosome-nascent polypeptide complexes. Indicus|evm.model.CM009494.1.414 Q9BSQ5 CCM2_HUMAN 90.337 0.930818 1.07432 CCM2 - Cerebral cavernous malformations 2 protein - Homo sapiens (Human) - CCM2 gene Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). Indicus|evm.model.CM009494.1.416 B0I1T2 MYO1G_HUMAN 91.552 0.997041 0.996071 MYO1G - Unconventional myosin-Ig - Homo sapiens (Human) - MYO1G gene Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. Indicus|evm.model.CM009494.1.417 Q96QR8 PURB_HUMAN 94.595 0.940789 0.974359 PURB - Transcriptional activator protein Pur-beta - Homo sapiens (Human) - PURB gene Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). Indicus|evm.model.CM009494.1.418 Q5BJ65 H2AV_XENTR 100.000 0.984496 1.00781 h2az2 - Histone H2A.V - Xenopus tropicalis (Western clawed frog) - h2az2 gene Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). Indicus|evm.model.CM009494.1.419 P62936 PPIA_PIG 100.000 0.987879 1.0061 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009494.1.421 Q8NF64 ZMIZ2_HUMAN 88.203 0.997833 1.00326 ZMIZ2 - Zinc finger MIZ domain-containing protein 2 - Homo sapiens (Human) - ZMIZ2 gene Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors. Indicus|evm.model.CM009494.1.422 Q148N0 ODO1_BOVIN 100.000 0.998047 1.00098 OGDH - 2-oxoglutarate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - OGDH gene 2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. Indicus|evm.model.CM009494.1.423 Q7Z7H5 TMED4_HUMAN 95.833 0.990783 0.955947 TMED4 - Transmembrane emp24 domain-containing protein 4 precursor - Homo sapiens (Human) - TMED4 gene Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity). Indicus|evm.model.CM009494.1.424 Q3SZ40 DDX56_BOVIN 100.000 0.996344 1.00183 DDX56 - Probable ATP-dependent RNA helicase DDX56 - Bos taurus (Bovine) - DDX56 gene May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity). Indicus|evm.model.CM009494.1.425 Q9UHC9 NPCL1_HUMAN 80.015 0.998501 0.981604 NPC1L1 - NPC1-like intracellular cholesterol transporter 1 precursor - Homo sapiens (Human) - NPC1L1 gene Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. Indicus|evm.model.CM009494.1.426 Q5RB75 NUDC3_PONAB 87.912 0.994444 0.99723 NUDCD3 - NudC domain-containing protein 3 - Pongo abelii (Sumatran orangutan) - NUDCD3 gene Indicus|evm.model.CM009494.1.427 Q9NSB8 HOME2_HUMAN 64.865 0.45625 0.451977 HOMER2 - Homer protein homolog 2 - Homo sapiens (Human) - HOMER2 gene Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). Indicus|evm.model.CM009494.1.428 Q3MHJ9 KCC2B_BOVIN 98.724 0.619651 1.16421 CAMK2B - Calcium/calmodulin-dependent protein kinase type II subunit beta - Bos taurus (Bovine) - CAMK2B gene Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. Indicus|evm.model.CM009494.1.429 Q3T000 YKT6_BOVIN 100.000 0.98995 1.00505 YKT6 - Synaptobrevin homolog YKT6 precursor - Bos taurus (Bovine) - YKT6 gene Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. Indicus|evm.model.CM009494.1.430 P35557 HXK4_HUMAN 96.659 0.963441 1 GCK - Hexokinase-4 - Homo sapiens (Human) - GCK gene Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:7742312, PubMed:11916951, PubMed:15277402, PubMed:17082186, PubMed:18322640, PubMed:19146401, PubMed:25015100, PubMed:8325892). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (PubMed:18322640, PubMed:25015100, PubMed:8325892, PubMed:11916951, PubMed:15277402). Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (By similarity). In pancreas, plays an important role in modulating insulin secretion (By similarity). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (By similarity). Required to provide D-glucose 6-phosphate for the synthesis of glycogen (PubMed:8878425). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:7742312). Indicus|evm.model.CM009494.1.431 F1SSF9 MLRA_PIG 98.286 0.988636 1.00571 MYL7 - Myosin regulatory light chain 2, atrial isoform - Sus scrofa (Pig) - MYL7 gene Indicus|evm.model.CM009494.1.432 P49004 DPOD2_BOVIN 100.000 0.995745 1.00213 POLD2 - DNA polymerase delta subunit 2 - Bos taurus (Bovine) - POLD2 gene Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7. Indicus|evm.model.CM009494.1.433 Q8IUX7 AEBP1_HUMAN 83.251 0.838654 1.00086 AEBP1 - Adipocyte enhancer-binding protein 1 precursor - Homo sapiens (Human) - AEBP1 gene As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix. Indicus|evm.model.CM009494.1.434 Q9NP87 DPOLM_HUMAN 82.057 0.995604 0.921053 POLM - DNA-directed DNA/RNA polymerase mu - Homo sapiens (Human) - POLM gene Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. Indicus|evm.model.CM009494.1.435 P53004 BIEA_HUMAN 92.230 0.993266 1.00338 BLVRA - Biliverdin reductase A precursor - Homo sapiens (Human) - BLVRA gene Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Indicus|evm.model.CM009494.1.437 Q9GZY4 COA1_HUMAN 71.111 0.977941 0.931507 COA1 - Cytochrome c oxidase assembly factor 1 homolog - Homo sapiens (Human) - COA1 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV. Indicus|evm.model.CM009494.1.438 Q9UEE5 ST17A_HUMAN 87.814 0.972028 0.690821 STK17A - Serine/threonine-protein kinase 17A - Homo sapiens (Human) - STK17A gene Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. Indicus|evm.model.CM009494.1.439 Q9UEE5 ST17A_HUMAN 90.647 0.985714 0.338164 STK17A - Serine/threonine-protein kinase 17A - Homo sapiens (Human) - STK17A gene Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. Indicus|evm.model.CM009494.1.440 Q76N89 HECW1_HUMAN 79.548 0.998974 0.607098 HECW1 - E3 ubiquitin-protein ligase HECW1 - Homo sapiens (Human) - HECW1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. Indicus|evm.model.CM009494.1.441 Q2TBI6 RM32_BOVIN 99.468 0.989418 1.00532 MRPL32 - 39S ribosomal protein L32, mitochondrial precursor - Bos taurus (Bovine) - MRPL32 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009494.1.442 P25787 PSA2_HUMAN 100.000 0.991489 1.00427 PSMA2 - Proteasome subunit alpha type-2 - Homo sapiens (Human) - PSMA2 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Indicus|evm.model.CM009494.1.443 Q1LZE8 CG025_BOVIN 100.000 0.995261 1.00238 UPF0415 protein C7orf25 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009494.1.445 A6H767 NP1L1_BOVIN 98.246 0.174455 0.820972 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009494.1.446 Q5IS56 GLI3_PANTR 87.987 0.998741 1.00506 GLI3 - Transcriptional activator GLI3 - Pan troglodytes (Chimpanzee) - GLI3 gene Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Plays a role in limb and brain development (By similarity). Indicus|evm.model.CM009494.1.448 P07995 INHBA_BOVIN 99.765 0.995305 1.00235 INHBA - Inhibin beta A chain precursor - Bos taurus (Bovine) - INHBA gene Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Indicus|evm.model.CM009494.1.449 Q9HAC7 SUCHY_HUMAN 91.781 0.947368 0.170787 SUGCT - Succinate--hydroxymethylglutarate CoA-transferase precursor - Homo sapiens (Human) - SUGCT gene Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate. Indicus|evm.model.CM009494.1.450 P54792 DVLP1_HUMAN 88.710 0.7625 0.119403 DVL1P1 - Putative segment polarity protein dishevelled homolog DVL1P1 - Homo sapiens (Human) - DVL1P1 gene May play a role in the signal transduction pathway mediated by multiple Wnt genes. Indicus|evm.model.CM009494.1.451 Q9HAC7 SUCHY_HUMAN 91.484 0.989101 0.824719 SUGCT - Succinate--hydroxymethylglutarate CoA-transferase precursor - Homo sapiens (Human) - SUGCT gene Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate. Indicus|evm.model.CM009494.1.452 Q8TAP9 MPLKI_HUMAN 94.413 0.988889 1.00559 MPLKIP - M-phase-specific PLK1-interacting protein - Homo sapiens (Human) - MPLKIP gene May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. Indicus|evm.model.CM009494.1.453 E1BB52 CDK13_BOVIN 99.934 0.998678 1.00066 CDK13 - Cyclin-dependent kinase 13 - Bos taurus (Bovine) - CDK13 gene Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis (By similarity). Indicus|evm.model.CM009494.1.454 Q9Z2U0 PSA7_MOUSE 83.784 0.888889 0.326613 Psma7 - Proteasome subunit alpha type-7 - Mus musculus (Mouse) - Psma7 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Indicus|evm.model.CM009494.1.455 P63320 RALA_SAGOE 99.515 0.990338 1.00485 RALA - Ras-related protein Ral-A precursor - Saguinus oedipus (Cotton-top tamarin) - RALA gene Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody. During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (By similarity). Indicus|evm.model.CM009494.1.456 Q9NRH1 YAE1_HUMAN 83.186 0.991189 1.00442 YAE1 - Protein YAE1 homolog - Homo sapiens (Human) - YAE1 gene The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:26182403). Indicus|evm.model.CM009494.1.457 P78424 PO6F2_HUMAN 98.857 0.794989 0.635311 POU6F2 - POU domain, class 6, transcription factor 2 - Homo sapiens (Human) - POU6F2 gene Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. Indicus|evm.model.CM009494.1.458 P78424 PO6F2_HUMAN 98.305 0.852941 0.0984081 POU6F2 - POU domain, class 6, transcription factor 2 - Homo sapiens (Human) - POU6F2 gene Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. Indicus|evm.model.CM009494.1.459 P49754 VPS41_HUMAN 97.658 0.997661 1.00117 VPS41 - Vacuolar protein sorting-associated protein 41 homolog - Homo sapiens (Human) - VPS41 gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847, PubMed:21802320). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660). Indicus|evm.model.CM009494.1.460 P49418 AMPH_HUMAN 88.218 0.99708 0.985612 AMPH - Amphiphysin - Homo sapiens (Human) - AMPH gene May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. Indicus|evm.model.CM009494.1.461 A0A0A0MS01 TVG10_HUMAN 59.091 0.215726 4.16807 TRGV10 - Probable non-functional T cell receptor gamma variable 10 precursor - Homo sapiens (Human) - TRGV10 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) gamma chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009494.1.463 A0A0A0MS01 TVG10_HUMAN 62.810 0.614583 1.61345 TRGV10 - Probable non-functional T cell receptor gamma variable 10 precursor - Homo sapiens (Human) - TRGV10 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) gamma chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009494.1.464 A5PK65 DOPD_BOVIN 92.958 0.972222 0.610169 DDT - D-dopachrome decarboxylase - Bos taurus (Bovine) - DDT gene Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Indicus|evm.model.CM009494.1.465 P06334 TCC3_MOUSE 60.215 0.910891 0.597633 T-cell receptor gamma chain C region DFL12 - Mus musculus (Mouse) Indicus|evm.model.CM009494.1.466 A0A0C4DH27 TRGV8_HUMAN 56.701 0.688889 1.14407 TRGV8 - T cell receptor gamma variable 8 precursor - Homo sapiens (Human) - TRGV8 gene V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009494.1.467 A0A0C4DH28 TRGV4_HUMAN 53.125 0.654135 1.12712 TRGV4 - T cell receptor gamma variable 4 precursor - Homo sapiens (Human) - TRGV4 gene V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009494.1.468 A0A0C4DH27 TRGV8_HUMAN 61.165 0.297376 2.90678 TRGV8 - T cell receptor gamma variable 8 precursor - Homo sapiens (Human) - TRGV8 gene V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009494.1.469 P03986 TRGC2_HUMAN 55.924 0.568681 1.92593 TRGC2 - T cell receptor gamma constant 2 - Homo sapiens (Human) - TRGC2 gene Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009494.1.470 Q5RCP3 LSM8_PONAB 100.000 0.884211 0.989583 LSM8 - U6 snRNA-associated Sm-like protein LSm8 - Pongo abelii (Sumatran orangutan) - LSM8 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Indicus|evm.model.CM009494.1.471 Q9ULM0 PKHH1_HUMAN 67.830 0.994667 0.274927 PLEKHH1 - Pleckstrin homology domain-containing family H member 1 - Homo sapiens (Human) - PLEKHH1 gene Indicus|evm.model.CM009494.1.472 Q5RA31 TOM20_PONAB 97.241 0.986301 1.0069 TOMM20 - Mitochondrial import receptor subunit TOM20 homolog - Pongo abelii (Sumatran orangutan) - TOMM20 gene Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. Indicus|evm.model.CM009494.1.473 O77834 PRDX6_BOVIN 94.643 0.991111 1.00446 PRDX6 - Peroxiredoxin-6 - Bos taurus (Bovine) - PRDX6 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10409692, PubMed:2373154). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10409692). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10409692, PubMed:2373154, PubMed:9787801). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity). Indicus|evm.model.CM009494.1.475 Q9NZV8 KCND2_HUMAN 98.837 0.898601 0.453968 KCND2 - Potassium voltage-gated channel subfamily D member 2 - Homo sapiens (Human) - KCND2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). Indicus|evm.model.CM009494.1.476 Q29RH7 TSN12_BOVIN 99.672 0.993464 1.00328 TSPAN12 - Tetraspanin-12 - Bos taurus (Bovine) - TSPAN12 gene Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). Indicus|evm.model.CM009494.1.478 Q9NXR8 ING3_HUMAN 98.086 0.995227 1.00239 ING3 - Inhibitor of growth protein 3 - Homo sapiens (Human) - ING3 gene Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Indicus|evm.model.CM009494.1.479 A4D0V7 CPED1_HUMAN 78.686 0.977077 0.680312 CPED1 - Cadherin-like and PC-esterase domain-containing protein 1 precursor - Homo sapiens (Human) - CPED1 gene endoplasmic reticulum Indicus|evm.model.CM009494.1.480 Q5E9U6 WNT16_BOVIN 99.724 0.99449 1.00276 WNT16 - Protein Wnt-16 precursor - Bos taurus (Bovine) - WNT16 gene Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Indicus|evm.model.CM009494.1.481 A5PKI3 FAM3C_BOVIN 100.000 0.991228 1.00441 FAM3C - Protein FAM3C precursor - Bos taurus (Bovine) - FAM3C gene May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition (By similarity). Indicus|evm.model.CM009494.1.484 P23471 PTPRZ_HUMAN 84.416 0.979104 1.01296 PTPRZ1 - Receptor-type tyrosine-protein phosphatase zeta precursor - Homo sapiens (Human) - PTPRZ1 gene Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). Indicus|evm.model.CM009494.1.485 A8E657 AASS_BOVIN 99.892 0.988248 1.0108 AASS - Alpha-aminoadipic semialdehyde synthase, mitochondrial precursor - Bos taurus (Bovine) - AASS gene Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-oxoglutarate reductase and saccharopine dehydrogenase activity, respectively (By similarity). Indicus|evm.model.CM009494.1.486 Q5R6X7 CBX3_PONAB 79.191 0.9875 0.874317 CBX3 - Chromobox protein homolog 3 - Pongo abelii (Sumatran orangutan) - CBX3 gene Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). Indicus|evm.model.CM009494.1.487 A0PJY2 FEZF1_HUMAN 93.694 0.82037 1.13684 FEZF1 - Fez family zinc finger protein 1 - Homo sapiens (Human) - FEZF1 gene Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity). Indicus|evm.model.CM009494.1.488 Q8BYR5 CAPS2_MOUSE 91.086 0.998119 0.819584 Cadps2 - Calcium-dependent secretion activator 2 - Mus musculus (Mouse) - Cadps2 gene Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. Indicus|evm.model.CM009494.1.489 Q8WVZ7 RN133_HUMAN 77.188 0.994709 1.00532 RNF133 - E3 ubiquitin-protein ligase RNF133 - Homo sapiens (Human) - RNF133 gene Has E3 ubiquitin-protein ligase activity. Indicus|evm.model.CM009494.1.490 Q2TA44 RN148_BOVIN 100.000 0.993421 1.0033 RNF148 - RING finger protein 148 precursor - Bos taurus (Bovine) - RNF148 gene cytoplasm, endoplasmic reticulum, Golgi apparatus, late endosome, ubiquitin protein ligase activity, ubiquitin-dependent protein catabolic process Indicus|evm.model.CM009494.1.491 Q9ULU8 CAPS1_HUMAN 83.117 0.383838 0.146341 CADPS - Calcium-dependent secretion activator 1 - Homo sapiens (Human) - CADPS gene Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). Indicus|evm.model.CM009494.1.492 Q646B3 T2R16_PANTR 57.966 0.97351 1.0378 TAS2R16 - Taste receptor type 2 member 16 - Pan troglodytes (Chimpanzee) - TAS2R16 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Indicus|evm.model.CM009494.1.493 Q9BZW2 S13A1_HUMAN 87.772 0.996656 1.00504 SLC13A1 - Solute carrier family 13 member 1 - Homo sapiens (Human) - SLC13A1 gene Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney. Indicus|evm.model.CM009494.1.494 Q8NA54 IQUB_HUMAN 74.559 0.994975 1.00632 IQUB - IQ and ubiquitin-like domain-containing protein - Homo sapiens (Human) - IQUB gene May play roles in cilia formation and/or maintenance. Indicus|evm.model.CM009494.1.495 P23935 NDUA5_BOVIN 100.000 0.982906 1.00862 NDUFA5 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 - Bos taurus (Bovine) - NDUFA5 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009494.1.496 Q8HXA6 ASB15_BOVIN 99.830 0.996604 1.0017 ASB15 - Ankyrin repeat and SOCS box protein 15 - Bos taurus (Bovine) - ASB15 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009494.1.497 Q6P5Q4 LMOD2_HUMAN 81.603 0.99604 0.923218 LMOD2 - Leiomodin-2 - Homo sapiens (Human) - LMOD2 gene Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:26370058, PubMed:25250574, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713). Indicus|evm.model.CM009494.1.498 Q95107 WASL_BOVIN 100.000 0.996047 1.00198 WASL - Neural Wiskott-Aldrich syndrome protein - Bos taurus (Bovine) - WASL gene Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:17609109). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity). Indicus|evm.model.CM009494.1.500 Q2M3T9 HYAL4_HUMAN 87.317 0.992718 0.856549 HYAL4 - Hyaluronidase-4 - Homo sapiens (Human) - HYAL4 gene Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide. Indicus|evm.model.CM009494.1.501 P38568 HYALP_MACFA 62.924 0.850181 1.08627 SPAM1 - Hyaluronidase PH-20 precursor - Macaca fascicularis (Crab-eating macaque) - SPAM1 gene Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. Indicus|evm.model.CM009494.1.502 A3QVN9 HYAL1_BITAR 49.173 0.882353 1.06013 Hyaluronidase-1 precursor - Bitis arietans (African puff adder) Indicus|evm.model.CM009494.1.503 P38568 HYALP_MACFA 65.347 0.82377 0.956863 SPAM1 - Hyaluronidase PH-20 precursor - Macaca fascicularis (Crab-eating macaque) - SPAM1 gene Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. Indicus|evm.model.CM009494.1.504 P15927 RFA2_HUMAN 89.423 0.980952 0.388889 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Indicus|evm.model.CM009494.1.505 Q5RC43 RFA2_PONAB 89.865 0.301848 1.8037 RPA2 - Replication protein A 32 kDa subunit - Pongo abelii (Sumatran orangutan) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Indicus|evm.model.CM009494.1.506 P24049 RL17_RAT 61.268 0.679012 0.880435 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009494.1.507 O15354 GPR37_HUMAN 88.436 0.996743 1.00163 GPR37 - Prosaposin receptor GPR37 precursor - Homo sapiens (Human) - GPR37 gene Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. Indicus|evm.model.CM009494.1.508 Q9NUX5 POTE1_HUMAN 85.893 0.810433 1.23975 POT1 - Protection of telomeres protein 1 - Homo sapiens (Human) - POT1 gene Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Indicus|evm.model.CM009494.1.509 P32233 DRG1_MOUSE 63.636 0.972727 0.299728 Drg1 - Developmentally-regulated GTP-binding protein 1 - Mus musculus (Mouse) - Drg1 gene Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions. Indicus|evm.model.CM009494.1.511 P68105 EF1A1_RABIT 63.740 0.990698 0.465368 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009494.1.512 Q9H4A5 GLP3L_HUMAN 72.549 0.925926 0.189474 GOLPH3L - Golgi phosphoprotein 3-like - Homo sapiens (Human) - GOLPH3L gene Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. Indicus|evm.model.CM009494.1.514 Q2TB10 ZN800_HUMAN 97.892 0.995495 1.00301 ZNF800 - Zinc finger protein 800 - Homo sapiens (Human) - ZNF800 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009494.1.515 Q96CN9 GCC1_HUMAN 92.903 0.997423 1.00129 GCC1 - GRIP and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - GCC1 gene Probably involved in maintaining Golgi structure. Indicus|evm.model.CM009494.1.516 P84083 ARF5_RAT 100.000 0.98895 1.00556 Arf5 - ADP-ribosylation factor 5 - Rattus norvegicus (Rat) - Arf5 gene GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Indicus|evm.model.CM009494.1.517 Q9QXW4 FSCN3_MOUSE 82.932 0.995992 1.00201 Fscn3 - Fascin-3 - Mus musculus (Mouse) - Fscn3 gene Acts as an actin bundling protein. Indicus|evm.model.CM009494.1.518 O43316 PAX4_HUMAN 89.496 0.967347 0.7 PAX4 - Paired box protein Pax-4 - Homo sapiens (Human) - PAX4 gene Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity. Indicus|evm.model.CM009494.1.520 Q863B3 SND1_BOVIN 97.970 0.953883 0.452747 SND1 - Staphylococcal nuclease domain-containing protein 1 - Bos taurus (Bovine) - SND1 gene Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity). Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity). Plays a role in PIM1 regulation of MYB activity (By similarity). Functions as a transcriptional coactivator for STAT5 (By similarity). Indicus|evm.model.CM009494.1.521 Q863B3 SND1_BOVIN 99.524 0.86722 0.264835 SND1 - Staphylococcal nuclease domain-containing protein 1 - Bos taurus (Bovine) - SND1 gene Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity). Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity). Plays a role in PIM1 regulation of MYB activity (By similarity). Functions as a transcriptional coactivator for STAT5 (By similarity). Indicus|evm.model.CM009494.1.522 Q9HBW1 LRRC4_HUMAN 98.162 0.996937 1 LRRC4 - Leucine-rich repeat-containing protein 4 precursor - Homo sapiens (Human) - LRRC4 gene Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). Indicus|evm.model.CM009494.1.524 Q863B3 SND1_BOVIN 100.000 0.9875 0.351648 SND1 - Staphylococcal nuclease domain-containing protein 1 - Bos taurus (Bovine) - SND1 gene Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity). Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity). Plays a role in PIM1 regulation of MYB activity (By similarity). Functions as a transcriptional coactivator for STAT5 (By similarity). Indicus|evm.model.CM009494.1.525 P50595 LEP_BOVIN 100.000 0.512346 1.94012 LEP - Leptin precursor - Bos taurus (Bovine) - LEP gene Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (By similarity). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (By similarity). Indicus|evm.model.CM009494.1.526 Q9NW13 RBM28_HUMAN 84.231 0.99734 0.990777 RBM28 - RNA-binding protein 28 - Homo sapiens (Human) - RBM28 gene Nucleolar component of the spliceosomal ribonucleoprotein complexes. Indicus|evm.model.CM009494.1.527 C9JH25 PRRT4_HUMAN 91.011 0.483651 0.816463 PRRT4 - Proline-rich transmembrane protein 4 precursor - Homo sapiens (Human) - PRRT4 gene Indicus|evm.model.CM009494.1.529 A0JNA3 IMDH1_BOVIN 100.000 0.896853 1.11284 IMPDH1 - Inosine-5'-monophosphate dehydrogenase 1 - Bos taurus (Bovine) - IMPDH1 gene Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Indicus|evm.model.CM009494.1.530 Q6NXP2 F71F2_HUMAN 72.903 0.990033 0.97411 FAM71F2 - Protein FAM71F2 - Homo sapiens (Human) - FAM71F2 gene Indicus|evm.model.CM009494.1.531 Q2KIP3 F71F1_BOVIN 99.420 0.994186 0.997101 FAM71F1 - Protein FAM71F1 - Bos taurus (Bovine) - FAM71F1 gene Indicus|evm.model.CM009494.1.532 Q3T0K1 CALU_BOVIN 77.165 0.824295 1.46349 CALU - Calumenin precursor - Bos taurus (Bovine) - CALU gene Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). Indicus|evm.model.CM009494.1.533 P51490 OPSB_BOVIN 99.713 0.994286 1.00287 OPN1SW - Short-wave-sensitive opsin 1 - Bos taurus (Bovine) - OPN1SW gene Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (By similarity). Involved in ensuring correct abundance and localization of retinal membrane proteins (By similarity). May increase spectral sensitivity in dim light (By similarity). Indicus|evm.model.CM009494.1.534 Q96JN2 CC136_HUMAN 73.652 0.950083 1.04159 CCDC136 - Coiled-coil domain-containing protein 136 - Homo sapiens (Human) - CCDC136 gene May play a role in acrosome formation in spermatogenesis and in fertilization. Indicus|evm.model.CM009494.1.535 Q14315 FLNC_HUMAN 98.386 0.999265 0.998532 FLNC - Filamin-C - Homo sapiens (Human) - FLNC gene Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. Indicus|evm.model.CM009494.1.536 Q28029 VATF_BOVIN 100.000 0.983333 1.0084 ATP6V1F - V-type proton ATPase subunit F - Bos taurus (Bovine) - ATP6V1F gene Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Indicus|evm.model.CM009494.1.537 A0A1B0GUX0 VAFNB_HUMAN 87.500 0.988701 1.00568 ATP6V1FNB - Protein ATP6V1FNB - Homo sapiens (Human) - ATP6V1FNB gene Indicus|evm.model.CM009494.1.539 Q6ZWJ8 KCP_HUMAN 74.576 0.726036 1.07781 KCP - Kielin/chordin-like protein precursor - Homo sapiens (Human) - KCP gene Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity). Indicus|evm.model.CM009494.1.540 Q58DJ0 IRF5_BOVIN 99.399 0.894075 1.11623 IRF5 - Interferon regulatory factor 5 - Bos taurus (Bovine) - IRF5 gene Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway. Indicus|evm.model.CM009494.1.541 Q9Y5L0 TNPO3_HUMAN 99.242 0.997835 1.00108 TNPO3 - Transportin-3 - Homo sapiens (Human) - TNPO3 gene Importin, which transports target proteins into the nucleus (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PubMed:30916345, PubMed:31465518). The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PubMed:23878195, PubMed:24449914). Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PubMed:23878195, PubMed:24449914). Indicus|evm.model.CM009494.1.542 Q3SYV5 TSN33_BOVIN 99.647 0.992958 1.00353 TSPAN33 - Tetraspanin-33 - Bos taurus (Bovine) - TSPAN33 gene Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). Indicus|evm.model.CM009494.1.543 Q99835 SMO_HUMAN 94.564 0.997439 0.992376 SMO - Smoothened homolog precursor - Homo sapiens (Human) - SMO gene G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). Indicus|evm.model.CM009494.1.544 A6QLP2 SAHH3_BOVIN 99.673 0.996727 1 AHCYL2 - Adenosylhomocysteinase 3 - Bos taurus (Bovine) - AHCYL2 gene May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (By similarity). Indicus|evm.model.CM009494.1.545 Q9ULQ0 STRP2_HUMAN 97.482 0.997605 1.0012 STRIP2 - Striatin-interacting protein 2 - Homo sapiens (Human) - STRIP2 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Indicus|evm.model.CM009494.1.546 Q62792 NRF1_RAT 100.000 0.10119 9.69231 Nrf1 - Nuclear respiratory factor 1 - Rattus norvegicus (Rat) - Nrf1 gene Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity). Indicus|evm.model.CM009494.1.547 Q00361 ATP5I_BOVIN 98.592 0.972222 1.01408 ATP5ME - ATP synthase subunit e, mitochondrial - Bos taurus (Bovine) - ATP5ME gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Indicus|evm.model.CM009494.1.548 P62257 UBE2H_MOUSE 100.000 0.98913 1.00546 Ube2h - Ubiquitin-conjugating enzyme E2 H - Mus musculus (Mouse) - Ube2h gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A. Indicus|evm.model.CM009494.1.549 Q86WB0 NIPA_HUMAN 89.022 0.99389 0.978088 ZC3HC1 - Nuclear-interacting partner of ALK - Homo sapiens (Human) - ZC3HC1 gene Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. Indicus|evm.model.CM009494.1.550 Q0IIC2 KLD10_BOVIN 100.000 0.995485 1.00226 KLHDC10 - Kelch domain-containing protein 10 - Bos taurus (Bovine) - KLHDC10 gene Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 (By similarity). Indicus|evm.model.CM009494.1.551 Q96SK2 TM209_HUMAN 96.786 0.960481 1.03743 TMEM209 - Transmembrane protein 209 - Homo sapiens (Human) - TMEM209 gene Indicus|evm.model.CM009494.1.552 Q4R309 SSMM1_MACFA 75.000 0.991736 0.991803 SSMEM1 - Serine-rich single-pass membrane protein 1 - Macaca fascicularis (Crab-eating macaque) - SSMEM1 gene Indicus|evm.model.CM009494.1.553 Q9UI42 CBPA4_HUMAN 71.667 0.995249 1 CPA4 - Carboxypeptidase A4 precursor - Homo sapiens (Human) - CPA4 gene Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). Indicus|evm.model.CM009494.1.554 Q8WXQ8 CBPA5_HUMAN 88.599 0.961098 1.00229 CPA5 - Carboxypeptidase A5 precursor - Homo sapiens (Human) - CPA5 gene extracellular space, metallocarboxypeptidase activity, proteolysis Indicus|evm.model.CM009494.1.555 P00730 CBPA1_BOVIN 99.761 0.995238 1.00239 CPA1 - Carboxypeptidase A1 precursor - Bos taurus (Bovine) - CPA1 gene Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (PubMed:12729612). Indicus|evm.model.CM009494.1.556 F1MUG2 CEP41_BOVIN 100.000 0.892086 1.11796 CEP41 - Centrosomal protein of 41 kDa - Bos taurus (Bovine) - CEP41 gene Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium (By similarity). Indicus|evm.model.CM009494.1.558 Q2HJM9 MEST_BOVIN 99.701 0.994048 1.00299 MEST - Mesoderm-specific transcript homolog protein - Bos taurus (Bovine) - MEST gene endoplasmic reticulum Indicus|evm.model.CM009494.1.559 Q9QXK3 COPG2_MOUSE 94.937 0.105263 0.850746 Copg2 - Coatomer subunit gamma-2 - Mus musculus (Mouse) - Copg2 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Indicus|evm.model.CM009494.1.560 Q3T028 TSG13_BOVIN 100.000 0.992674 1.00368 TSGA13 - Testis-specific gene 13 protein - Bos taurus (Bovine) - TSGA13 gene Indicus|evm.model.CM009494.1.561 Q19A40 KLF14_PANTR 88.652 0.737968 0.578947 KLF14 - Krueppel-like factor 14 - Pan troglodytes (Chimpanzee) - KLF14 gene DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009494.1.562 Q5RB35 MKLN1_PONAB 99.592 0.997283 1.00136 MKLN1 - Muskelin - Pongo abelii (Sumatran orangutan) - MKLN1 gene Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity). Indicus|evm.model.CM009494.1.563 Q52S86 PODXL_CANLF 66.255 0.409864 1.02977 PODXL - Podocalyxin precursor - Canis lupus familiaris (Dog) - PODXL gene Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. Indicus|evm.model.CM009494.1.564 Q6GQ22 KMCP1_XENLA 77.982 0.517073 0.704467 slc25a30 - Kidney mitochondrial carrier protein 1 - Xenopus laevis (African clawed frog) - slc25a30 gene Probable transporter. Indicus|evm.model.CM009494.1.566 Q9HCM2 PLXA4_HUMAN 97.853 0.891291 0.854805 PLXNA4 - Plexin-A4 precursor - Homo sapiens (Human) - PLXNA4 gene Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). Indicus|evm.model.CM009494.1.567 Q8NGH9 O52E4_HUMAN 65.022 0.991071 0.717949 OR52E4 - Olfactory receptor 52E4 - Homo sapiens (Human) - OR52E4 gene Odorant receptor. Indicus|evm.model.CM009494.1.568 Q9H2C5 O52A5_HUMAN 60.547 0.972763 0.813291 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Indicus|evm.model.CM009494.1.569 Q80UG2 PLXA4_MOUSE 96.711 0.732689 0.328051 Plxna4 - Plexin-A4 precursor - Mus musculus (Mouse) - Plxna4 gene Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Indicus|evm.model.CM009494.1.570 Q5E9D3 MIC19_BOVIN 99.119 0.991228 1.00441 CHCHD3 - MICOS complex subunit MIC19 - Bos taurus (Bovine) - CHCHD3 gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. Indicus|evm.model.CM009494.1.571 Q96A65 EXOC4_HUMAN 97.006 0.996016 0.5154 EXOC4 - Exocyst complex component 4 - Homo sapiens (Human) - EXOC4 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Indicus|evm.model.CM009494.1.572 Q96M69 LRGUK_HUMAN 76.113 0.95974 0.933333 LRGUK - Leucine-rich repeat and guanylate kinase domain-containing protein - Homo sapiens (Human) - LRGUK gene Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. Indicus|evm.model.CM009494.1.573 Q95KB4 S35B4_MACFA 93.485 0.9653 0.957704 SLC35B4 - UDP-xylose and UDP-N-acetylglucosamine transporter - Macaca fascicularis (Crab-eating macaque) - SLC35B4 gene Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi. Indicus|evm.model.CM009494.1.574 P97364 SPS2_MOUSE 80.723 0.58156 0.311947 Sephs2 - Selenide, water dikinase 2 - Mus musculus (Mouse) - Sephs2 gene Synthesizes selenophosphate from selenide and ATP. Indicus|evm.model.CM009494.1.576 P16116 ALDR_BOVIN 99.365 0.990536 1.00635 AKR1B1 - Aldo-keto reductase family 1 member B1 - Bos taurus (Bovine) - AKR1B1 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Indicus|evm.model.CM009494.1.577 O60218 AK1BA_HUMAN 78.481 0.993569 0.984177 AKR1B10 - Aldo-keto reductase family 1 member B10 - Homo sapiens (Human) - AKR1B10 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). Indicus|evm.model.CM009494.1.578 Q3T014 PMGE_BOVIN 99.228 0.877551 1.13514 BPGM - Bisphosphoglycerate mutase - Bos taurus (Bovine) - BPGM gene Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. Indicus|evm.model.CM009494.1.579 Q27976 CALD1_BOVIN 95.312 0.0797468 9.51807 CALD1 - Non-muscle caldesmon - Bos taurus (Bovine) - CALD1 gene Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Indicus|evm.model.CM009494.1.580 E1B9D8 CBPC3_BOVIN 94.622 0.997932 0.964108 AGBL3 - Cytosolic carboxypeptidase 3 - Bos taurus (Bovine) - AGBL3 gene Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. Indicus|evm.model.CM009494.1.581 Q9NV12 TM140_HUMAN 71.591 0.925926 1.02162 TMEM140 - Transmembrane protein 140 - Homo sapiens (Human) - TMEM140 gene Indicus|evm.model.CM009494.1.582 Q9BWK5 CYREN_HUMAN 62.346 0.987013 0.980892 CYREN - Cell cycle regulator of non-homologous end joining - Homo sapiens (Human) - CYREN gene Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974). May act as a regulator of proteasome (By similarity). Indicus|evm.model.CM009494.1.584 Q2HJE1 WDR91_BOVIN 96.113 0.997234 0.969169 WDR91 - WD repeat-containing protein 91 - Bos taurus (Bovine) - WDR91 gene Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis. Indicus|evm.model.CM009494.1.585 Q7Z7C7 STRA8_HUMAN 73.913 0.322946 1.0697 STRA8 - Stimulated by retinoic acid gene 8 protein homolog - Homo sapiens (Human) - STRA8 gene Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. Indicus|evm.model.CM009494.1.586 Q9EPR4 S23A2_MOUSE 52.407 0.883607 0.941358 Slc23a2 - Solute carrier family 23 member 2 - Mus musculus (Mouse) - Slc23a2 gene Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity). Indicus|evm.model.CM009494.1.587 O95628 CNOT4_HUMAN 98.895 0.842187 1.11304 CNOT4 - CCR4-NOT transcription complex subunit 4 - Homo sapiens (Human) - CNOT4 gene Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391). Indicus|evm.model.CM009494.1.589 Q92621 NU205_HUMAN 96.272 0.964046 1.03678 NUP205 - Nuclear pore complex protein Nup205 - Homo sapiens (Human) - NUP205 gene Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). Indicus|evm.model.CM009494.1.590 Q9UKG4 S13A4_HUMAN 90.940 0.947368 1.0016 SLC13A4 - Solute carrier family 13 member 4 - Homo sapiens (Human) - SLC13A4 gene Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV). Indicus|evm.model.CM009494.1.591 Q6UWF9 F180A_HUMAN 83.815 0.988506 1.00578 FAM180A - Protein FAM180A precursor - Homo sapiens (Human) - FAM180A gene Indicus|evm.model.CM009494.1.592 P58546 MTPN_HUMAN 100.000 0.983193 1.00847 MTPN - Myotrophin - Homo sapiens (Human) - MTPN gene Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Indicus|evm.model.CM009494.1.593 O00566 MPP10_HUMAN 74.872 0.989796 0.287812 MPHOSPH10 - U3 small nucleolar ribonucleoprotein protein MPP10 - Homo sapiens (Human) - MPHOSPH10 gene Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Indicus|evm.model.CM009494.1.594 O00566 MPP10_HUMAN 84.599 0.995736 0.688693 MPHOSPH10 - U3 small nucleolar ribonucleoprotein protein MPP10 - Homo sapiens (Human) - MPHOSPH10 gene Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Indicus|evm.model.CM009494.1.596 P41985 ACM2_BOVIN 100.000 0.995708 1.00215 CHRM2 - Muscarinic acetylcholine receptor M2 - Bos taurus (Bovine) - CHRM2 gene The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity). Indicus|evm.model.CM009494.1.597 P21782 PTN_BOVIN 100.000 0.988166 1.00595 PTN - Pleiotrophin precursor - Bos taurus (Bovine) - PTN gene Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:1550956) (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway. Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion. Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway. Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration. In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity). Indicus|evm.model.CM009494.1.598 O75912 DGKI_HUMAN 98.540 0.944444 0.135211 DGKI - Diacylglycerol kinase iota - Homo sapiens (Human) - DGKI gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9830018, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:9830018). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity). Indicus|evm.model.CM009494.1.599 F1MAB7 DGKI_RAT 94.541 0.98913 0.700952 Dgki - Diacylglycerol kinase iota - Rattus norvegicus (Rat) - Dgki gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15024004). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:15024004). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity). Indicus|evm.model.CM009494.1.600 F1MAB7 DGKI_RAT 92.405 0.696429 0.106667 Dgki - Diacylglycerol kinase iota - Rattus norvegicus (Rat) - Dgki gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15024004). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:15024004). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity). Indicus|evm.model.CM009494.1.601 Q5RCM9 CR3L2_PONAB 82.885 0.995708 0.896154 CREB3L2 - Cyclic AMP-responsive element-binding protein 3-like protein 2 - Pongo abelii (Sumatran orangutan) - CREB3L2 gene Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site (By similarity). Indicus|evm.model.CM009494.1.604 O15164 TIF1A_HUMAN 96.762 0.998097 1.00095 TRIM24 - Transcription intermediary factor 1-alpha - Homo sapiens (Human) - TRIM24 gene Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Indicus|evm.model.CM009494.1.605 Q8N434 SVOPL_HUMAN 88.477 0.864636 1.20122 SVOPL - Putative transporter SVOPL - Homo sapiens (Human) - SVOPL gene Indicus|evm.model.CM009494.1.606 Q9HBG4 VPP4_HUMAN 85.714 0.997605 0.994048 ATP6V0A4 - V-type proton ATPase 116 kDa subunit a isoform 4 - Homo sapiens (Human) - ATP6V0A4 gene Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. Indicus|evm.model.CM009494.1.607 Q58CU5 TM213_BOVIN 100.000 0.823077 1.2037 TMEM213 - Transmembrane protein 213 precursor - Bos taurus (Bovine) - TMEM213 gene Indicus|evm.model.CM009494.1.609 Q9HCM3 K1549_HUMAN 76.263 0.998364 0.940513 KIAA1549 - UPF0606 protein KIAA1549 - Homo sapiens (Human) - KIAA1549 gene May play a role in photoreceptor function. Indicus|evm.model.CM009494.1.610 Q96H79 ZCCHL_HUMAN 82.034 0.97651 0.993333 ZC3HAV1L - Zinc finger CCCH-type antiviral protein 1-like - Homo sapiens (Human) - ZC3HAV1L gene cytosol Indicus|evm.model.CM009494.1.611 Q7Z2W4 ZCCHV_HUMAN 57.111 0.997622 0.932373 ZC3HAV1 - Zinc finger CCCH-type antiviral protein 1 - Homo sapiens (Human) - ZC3HAV1 gene Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). Indicus|evm.model.CM009494.1.612 Q8BS45 IFT56_MOUSE 97.653 0.996396 1.00181 Ttc26 - Intraflagellar transport protein 56 - Mus musculus (Mouse) - Ttc26 gene Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU (PubMed:22718903, PubMed:25340710). Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme (PubMed:28264835). Indicus|evm.model.CM009494.1.613 E1B7L7 UBN2_BOVIN 100.000 0.998497 1.00075 UBN2 - Ubinuclein-2 - Bos taurus (Bovine) - UBN2 gene Indicus|evm.model.CM009494.1.615 Q3SZA2 FMC1_BOVIN 100.000 0.982456 1.00885 FMC1 - Protein FMC1 homolog - Bos taurus (Bovine) - FMC1 gene Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V). Indicus|evm.model.CM009494.1.616 Q7TNC4 LC7L2_MOUSE 98.980 0.994911 1.00255 Luc7l2 - Putative RNA-binding protein Luc7-like 2 - Mus musculus (Mouse) - Luc7l2 gene May bind to RNA via its Arg/Ser-rich domain. Indicus|evm.model.CM009494.1.617 A4D1S0 KLRG2_HUMAN 60.748 0.981308 1.04645 KLRG2 - Killer cell lectin-like receptor subfamily G member 2 - Homo sapiens (Human) - KLRG2 gene Indicus|evm.model.CM009494.1.618 P0C7M8 CLC2L_HUMAN 96.923 0.984733 0.61215 CLEC2L - C-type lectin domain family 2 member L - Homo sapiens (Human) - CLEC2L gene Indicus|evm.model.CM009494.1.619 Q9H2X6 HIPK2_HUMAN 96.647 0.986744 1.00751 HIPK2 - Homeodomain-interacting protein kinase 2 - Homo sapiens (Human) - HIPK2 gene Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Indicus|evm.model.CM009494.1.621 Q2KIG5 THAS_BOVIN 99.422 0.996154 0.97561 TBXAS1 - Thromboxane-A synthase - Bos taurus (Bovine) - TBXAS1 gene Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE. Indicus|evm.model.CM009494.1.622 Q9H0J9 PAR12_HUMAN 73.684 0.997155 1.00285 PARP12 - Protein mono-ADP-ribosyltransferase PARP12 - Homo sapiens (Human) - PARP12 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Indicus|evm.model.CM009494.1.623 Q6ZMT4 KDM7A_HUMAN 93.387 0.867327 1.07333 KDM7A - Lysine-specific demethylase 7A - Homo sapiens (Human) - KDM7A gene Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. Indicus|evm.model.CM009494.1.624 Q17QZ3 SPX3_BOVIN 99.596 0.995968 1.00202 SLC37A3 - Sugar phosphate exchanger 3 - Bos taurus (Bovine) - SLC37A3 gene integral component of endoplasmic reticulum membrane Indicus|evm.model.CM009494.1.625 Q3ZC27 RAB19_BOVIN 100.000 0.990826 1.00461 RAB19 - Ras-related protein Rab-19 - Bos taurus (Bovine) - RAB19 gene endomembrane system, GTPase activity, autophagosome assembly, intracellular protein transport Indicus|evm.model.CM009494.1.626 Q9UHC7 MKRN1_HUMAN 95.487 0.278853 3.10996 MKRN1 - E3 ubiquitin-protein ligase makorin-1 - Homo sapiens (Human) - MKRN1 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. Indicus|evm.model.CM009494.1.627 Q7Z695 ADCK2_HUMAN 78.812 0.992013 1 ADCK2 - Uncharacterized aarF domain-containing protein kinase 2 - Homo sapiens (Human) - ADCK2 gene The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr). Indicus|evm.model.CM009494.1.628 Q02374 NDUB2_BOVIN 99.074 0.981651 1.00926 NDUFB2 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor - Bos taurus (Bovine) - NDUFB2 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009494.1.629 P10533 RMIL_AVII1 99.183 0.477184 2.08992 V-RMIL - Serine/threonine-protein kinase-transforming protein Rmil - Avian retrovirus IC10 - V-RMIL gene Indicus|evm.model.CM009494.1.630 P82926 RT33_BOVIN 100.000 0.981308 1.00943 MRPS33 - 28S ribosomal protein S33, mitochondrial - Bos taurus (Bovine) - MRPS33 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion Indicus|evm.model.CM009494.1.633 H3BS89 T178B_HUMAN 98.165 0.857143 0.428571 TMEM178B - Transmembrane protein 178B precursor - Homo sapiens (Human) - TMEM178B gene membrane Indicus|evm.model.CM009494.1.634 H3BS89 T178B_HUMAN 86.957 0.314286 0.47619 TMEM178B - Transmembrane protein 178B precursor - Homo sapiens (Human) - TMEM178B gene membrane Indicus|evm.model.CM009494.1.636 P46783 RS10_HUMAN 72.414 0.982609 0.69697 RPS10 - 40S ribosomal protein S10 - Homo sapiens (Human) - RPS10 gene Component of the 40S ribosomal subunit. Indicus|evm.model.CM009494.1.637 H3BS89 T178B_HUMAN 98.462 0.518072 0.846939 TMEM178B - Transmembrane protein 178B precursor - Homo sapiens (Human) - TMEM178B gene membrane Indicus|evm.model.CM009494.1.639 Q53H12 AGK_HUMAN 91.469 0.995249 0.99763 AGK - Acylglycerol kinase, mitochondrial - Homo sapiens (Human) - AGK gene Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762). Does not phosphorylate sphingosine (PubMed:15939762). Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed:28712724, PubMed:28712726). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed:28712724). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed:15939762). Indicus|evm.model.CM009494.1.640 A4D1U4 DEN11_HUMAN 98.077 0.994521 0.802198 DENND11 - DENN domain-containing protein 11 - Homo sapiens (Human) - DENND11 gene Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Indicus|evm.model.CM009494.1.641 A4PES0 WEE2_PIG 76.637 0.739816 1.3469 WEE2 - Wee1-like protein kinase 2 - Sus scrofa (Pig) - WEE2 gene Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. Indicus|evm.model.CM009494.1.642 Q646E8 TA2R3_PAPHA 69.231 0.981073 1.00635 TAS2R3 - Taste receptor type 2 member 3 - Papio hamadryas (Hamadryas baboon) - TAS2R3 gene Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). Indicus|evm.model.CM009494.1.643 Q646D5 TA2R5_PANPA 77.419 0.414414 0.742475 TAS2R5 - Taste receptor type 2 member 5 - Pan paniscus (Pygmy chimpanzee) - TAS2R5 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Indicus|evm.model.CM009494.1.644 Q32KU2 PRS37_BOVIN 100.000 0.991525 1.00426 PRSS37 - Probable inactive serine protease 37 precursor - Bos taurus (Bovine) - PRSS37 gene Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system. Indicus|evm.model.CM009494.1.646 Q9NY25 CLC5A_HUMAN 78.261 0.968085 0.5 CLEC5A - C-type lectin domain family 5 member A - Homo sapiens (Human) - CLEC5A gene Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (By similarity). Indicus|evm.model.CM009494.1.647 Q697L5 T2R38_PANTR 68.882 0.982143 1.00901 TAS2R38 - Taste receptor type 2 member 38 - Pan troglodytes (Chimpanzee) - TAS2R38 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Indicus|evm.model.CM009494.1.648 O43451 MGA_HUMAN 84.561 0.409814 2.37049 MGAM - Maltase-glucoamylase, intestinal - Homo sapiens (Human) - MGAM gene May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. Indicus|evm.model.CM009494.1.649 A6NHM9 MOXD2_HUMAN 85.600 0.806139 1.24048 MOXD2P - Putative DBH-like monooxygenase protein 2 precursor - Homo sapiens (Human) - MOXD2P gene extracellular space, secretory granule membrane, copper ion binding, dopamine beta-monooxygenase activity, dopamine catabolic process, norepinephrine biosynthetic process, octopamine biosynthetic process Indicus|evm.model.CM009494.1.650 P04214 TVB6_MOUSE 62.500 0.7 1.10294 T-cell receptor beta chain V region E1 precursor - Mus musculus (Mouse) Indicus|evm.model.CM009494.1.652 Q32LI2 PRS58_BOVIN 99.174 0.983673 1.0124 PRSS58 - Probable inactive serine protease 58 precursor - Bos taurus (Bovine) - PRSS58 gene secretory granule Indicus|evm.model.CM009494.1.654 P00760 TRY1_BOVIN 100.000 0.991903 1.00407 Cationic trypsin precursor - Bos taurus (Bovine) Indicus|evm.model.CM009494.1.655 P00760 TRY1_BOVIN 99.593 0.991903 1.00407 Cationic trypsin precursor - Bos taurus (Bovine) Indicus|evm.model.CM009494.1.656 A0A576 TVB31_HUMAN 72.566 0.982456 1 TRBV3-1 - T cell receptor beta variable 3-1 precursor - Homo sapiens (Human) - TRBV3-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.657 A0A577 TVB41_HUMAN 68.687 0.505155 1.70175 TRBV4-1 - T cell receptor beta variable 4-1 precursor - Homo sapiens (Human) - TRBV4-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.658 A0A0B4J1U6 TVB9_HUMAN 66.372 0.741722 1.32456 TRBV9 - T cell receptor beta variable 9 precursor - Homo sapiens (Human) - TRBV9 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.659 A0A0B4J1U6 TVB9_HUMAN 65.487 0.480687 2.04386 TRBV9 - T cell receptor beta variable 9 precursor - Homo sapiens (Human) - TRBV9 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.660 A0A0K0K1A5 TVB65_HUMAN 67.677 0.725926 1.18421 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.661 P63170 DYL1_RAT 84.146 0.55102 1.65169 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Indicus|evm.model.CM009494.1.662 A0A0K0K1A5 TVB65_HUMAN 69.697 0.736842 1.16667 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.663 P11364 TCB_FLV 69.565 0.904762 0.392523 V-TCR - Viral T-cell receptor beta chain-like T17T-22 precursor - Feline leukemia virus - V-TCR gene Indicus|evm.model.CM009494.1.664 A0A1B0GX49 TVB64_HUMAN 65.138 0.404494 2.34211 TRBV6-4 - T cell receptor beta variable 6-4 precursor - Homo sapiens (Human) - TRBV6-4 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.665 P11364 TCB_FLV 71.681 0.268585 1.29907 V-TCR - Viral T-cell receptor beta chain-like T17T-22 precursor - Feline leukemia virus - V-TCR gene Indicus|evm.model.CM009494.1.666 A0A0K0K1D8 TVB61_HUMAN 68.142 0.823529 1.19298 TRBV6-1 - T cell receptor beta variable 6-1 precursor - Homo sapiens (Human) - TRBV6-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.667 A0A0K0K1A5 TVB65_HUMAN 67.677 0.75969 1.13158 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.668 P63170 DYL1_RAT 84.932 0.972973 0.831461 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Indicus|evm.model.CM009494.1.669 P11364 TCB_FLV 69.565 0.850746 0.417445 V-TCR - Viral T-cell receptor beta chain-like T17T-22 precursor - Feline leukemia virus - V-TCR gene Indicus|evm.model.CM009494.1.670 A0A0K0K1A5 TVB65_HUMAN 68.687 0.736842 1.16667 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.671 A0A599 TVB56_HUMAN 64.211 0.622517 1.32456 TRBV5-6 - T cell receptor beta variable 5-6 precursor - Homo sapiens (Human) - TRBV5-6 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.672 A0A0K0K1A5 TVB65_HUMAN 65.657 0.695035 1.23684 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.673 A0A0B4J1U6 TVB9_HUMAN 69.027 0.259259 3.78947 TRBV9 - T cell receptor beta variable 9 precursor - Homo sapiens (Human) - TRBV9 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.674 P11364 TCB_FLV 67.826 0.786207 0.451713 V-TCR - Viral T-cell receptor beta chain-like T17T-22 precursor - Feline leukemia virus - V-TCR gene Indicus|evm.model.CM009494.1.675 A0A599 TVB56_HUMAN 66.316 0.614379 1.34211 TRBV5-6 - T cell receptor beta variable 5-6 precursor - Homo sapiens (Human) - TRBV5-6 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.676 A0A577 TVB41_HUMAN 67.677 0.675862 1.27193 TRBV4-1 - T cell receptor beta variable 4-1 precursor - Homo sapiens (Human) - TRBV4-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.677 A0A1B0GX49 TVB64_HUMAN 66.372 0.861538 1.14035 TRBV6-4 - T cell receptor beta variable 6-4 precursor - Homo sapiens (Human) - TRBV6-4 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.678 A0A0B4J1U6 TVB9_HUMAN 65.487 0.513761 1.91228 TRBV9 - T cell receptor beta variable 9 precursor - Homo sapiens (Human) - TRBV9 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.679 A0A0K0K1A5 TVB65_HUMAN 65.657 0.720588 1.19298 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.680 A0A0K0K1A5 TVB65_HUMAN 66.667 0.358974 2.39474 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.681 A0A0K0K1A5 TVB65_HUMAN 68.041 0.276657 3.04386 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.682 A0A597 TVB55_HUMAN 70.707 0.823529 1.04386 TRBV5-5 - T cell receptor beta variable 5-5 precursor - Homo sapiens (Human) - TRBV5-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.683 A0A0B4J2E0 TVBL4_HUMAN 71.930 0.163295 6.01739 TRBV12-4 - T cell receptor beta variable 12-4 precursor - Homo sapiens (Human) - TRBV12-4 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.685 A0A075B6N1 TVB19_HUMAN 69.912 0.875 1.12281 TRBV19 - T cell receptor beta variable 19 precursor - Homo sapiens (Human) - TRBV19 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.686 A0A075B6N1 TVB19_HUMAN 69.355 0.348571 1.53509 TRBV19 - T cell receptor beta variable 19 precursor - Homo sapiens (Human) - TRBV19 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.687 A0A0A0MS06 TVB23_HUMAN 56.122 0.776 1.08696 TRBV23-1 - Probable non-functional T cell receptor beta variable 23-1 precursor - Homo sapiens (Human) - TRBV23-1 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.688 A0A0A0MS06 TVB23_HUMAN 55.102 0.774194 1.07826 TRBV23-1 - Probable non-functional T cell receptor beta variable 23-1 precursor - Homo sapiens (Human) - TRBV23-1 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.689 A0A075B6N1 TVB19_HUMAN 71.171 0.242291 3.98246 TRBV19 - T cell receptor beta variable 19 precursor - Homo sapiens (Human) - TRBV19 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.690 A0A0A0MS06 TVB23_HUMAN 56.122 0.776 1.08696 TRBV23-1 - Probable non-functional T cell receptor beta variable 23-1 precursor - Homo sapiens (Human) - TRBV23-1 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.691 A0A075B6N2 TVBT1_HUMAN 65.625 0.549133 1.55856 TRBV20-1 - T cell receptor beta variable 20-1 precursor - Homo sapiens (Human) - TRBV20-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.692 P01734 TVB1_MOUSE 48.000 0.860465 0.637037 T-cell receptor beta chain V region 3H.25 precursor - Mus musculus (Mouse) Indicus|evm.model.CM009494.1.693 A0A0A0MS06 TVB23_HUMAN 54.082 0.776 1.08696 TRBV23-1 - Probable non-functional T cell receptor beta variable 23-1 precursor - Homo sapiens (Human) - TRBV23-1 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.694 A0A0A0MS06 TVB23_HUMAN 52.041 0.776 1.08696 TRBV23-1 - Probable non-functional T cell receptor beta variable 23-1 precursor - Homo sapiens (Human) - TRBV23-1 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.695 A0A075B6N1 TVB19_HUMAN 61.856 0.673759 1.23684 TRBV19 - T cell receptor beta variable 19 precursor - Homo sapiens (Human) - TRBV19 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.696 A0A075B6N4 TVBY1_HUMAN 74.561 0.389655 2.54386 TRBV25-1 - T cell receptor beta variable 25-1 precursor - Homo sapiens (Human) - TRBV25-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.697 A0A0A6YYG2 TVB66_HUMAN 60.825 0.662069 1.27193 TRBV6-6 - T cell receptor beta variable 6-6 precursor - Homo sapiens (Human) - TRBV6-6 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.698 A0A0K0K1C4 TVB27_HUMAN 65.487 0.949153 1.03509 TRBV27 - T cell receptor beta variable 27 precursor - Homo sapiens (Human) - TRBV27 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.699 A0A5B7 TVB29_HUMAN 73.196 0.303797 2.84685 TRBV29-1 - T cell receptor beta variable 29-1 precursor - Homo sapiens (Human) - TRBV29-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.700 A0A5B7 TVB29_HUMAN 69.737 0.75 0.900901 TRBV29-1 - T cell receptor beta variable 29-1 precursor - Homo sapiens (Human) - TRBV29-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.701 A0A5B7 TVB29_HUMAN 75.258 0.258065 3.35135 TRBV29-1 - T cell receptor beta variable 29-1 precursor - Homo sapiens (Human) - TRBV29-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.702 Q29463 TRY2_BOVIN 98.785 0.991935 1.00405 Anionic trypsin precursor - Bos taurus (Bovine) Indicus|evm.model.CM009494.1.703 A0A5B9 TRBC2_HUMAN 80.899 0.240489 4.13483 TRBC2 - T cell receptor beta constant 2 - Homo sapiens (Human) - TRBC2 gene Constant region of T cell receptor (TR) beta chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.704 A0A0K0K1B3 TVB30_HUMAN 73.737 0.720588 1.22523 TRBV30 - T cell receptor beta variable 30 precursor - Homo sapiens (Human) - TRBV30 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009494.1.705 P0C0K6 EPHB6_PANTR 91.373 0.998016 0.988235 EPHB6 - Ephrin type-B receptor 6 precursor - Pan troglodytes (Chimpanzee) - EPHB6 gene Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). Indicus|evm.model.CM009494.1.706 Q9H1D0 TRPV6_HUMAN 83.034 0.99723 0.943791 TRPV6 - Transient receptor potential cation channel subfamily V member 6 - Homo sapiens (Human) - TRPV6 gene Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Indicus|evm.model.CM009494.1.707 Q9XSM3 TRPV5_RABIT 82.507 0.990437 1.00274 Trpv5 - Transient receptor potential cation channel subfamily V member 5 - Oryctolagus cuniculus (Rabbit) - Trpv5 gene Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:10085067, PubMed:11035011, PubMed:12574114, PubMed:29323279). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:29323279). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (PubMed:11035011). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114). Indicus|evm.model.CM009494.1.708 Q96L11 LCFC1_HUMAN 63.810 0.971963 0.877049 LLCFC1 - Sperm-egg fusion protein LLCFC1 precursor - Homo sapiens (Human) - LLCFC1 gene Sperm protein required for fusion of sperm with the egg membrane during fertilization. Indicus|evm.model.CM009494.1.709 P23276 KELL_HUMAN 67.967 0.99169 0.986339 KEL - Kell blood group glycoprotein - Homo sapiens (Human) - KEL gene Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. Indicus|evm.model.CM009494.1.710 Q8NGT5 OR9A2_HUMAN 79.936 0.993631 1.0129 OR9A2 - Olfactory receptor 9A2 - Homo sapiens (Human) - OR9A2 gene Odorant receptor. Indicus|evm.model.CM009494.1.711 Q8N148 OR6V1_HUMAN 83.648 0.981366 0.514377 OR6V1 - Olfactory receptor 6V1 - Homo sapiens (Human) - OR6V1 gene Odorant receptor. Indicus|evm.model.CM009494.1.715 P59534 T2R39_HUMAN 64.583 0.962644 1.02959 TAS2R39 - Taste receptor type 2 member 39 - Homo sapiens (Human) - TAS2R39 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Indicus|evm.model.CM009494.1.716 Q646F2 T2R40_PAPHA 59.928 0.950943 0.820433 TAS2R40 - Taste receptor type 2 member 40 - Papio hamadryas (Hamadryas baboon) - TAS2R40 gene Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). Indicus|evm.model.CM009494.1.717 Q9Y2Q3 GSTK1_HUMAN 77.434 0.991189 1.00442 GSTK1 - Glutathione S-transferase kappa 1 - Homo sapiens (Human) - GSTK1 gene Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB). Indicus|evm.model.CM009494.1.718 Q8IV31 TM139_HUMAN 65.741 0.990431 0.967593 TMEM139 - Transmembrane protein 139 precursor - Homo sapiens (Human) - TMEM139 gene May be involved in cellular trafficking of proteins such as SLC4A1. Indicus|evm.model.CM009494.1.719 P42575 CASP2_HUMAN 88.053 0.995585 1.00221 CASP2 - Caspase-2 precursor - Homo sapiens (Human) - CASP2 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). Indicus|evm.model.CM009494.1.720 P35523 CLCN1_HUMAN 87.462 0.997978 1.00101 CLCN1 - Chloride channel protein 1 - Homo sapiens (Human) - CLCN1 gene Voltage-gated chloride channel (PubMed:8112288, PubMed:9122265, PubMed:12456816). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (Probable). The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). Indicus|evm.model.CM009494.1.721 A0JNG6 F131B_BOVIN 100.000 0.831832 0.982301 FAM131B - Protein FAM131B - Bos taurus (Bovine) - FAM131B gene Indicus|evm.model.CM009494.1.722 Q15942 ZYX_HUMAN 87.184 0.996047 0.884615 ZYX - Zyxin - Homo sapiens (Human) - ZYX gene Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). Indicus|evm.model.CM009494.1.723 P21709 EPHA1_HUMAN 87.182 0.997967 1.0082 EPHA1 - Ephrin type-A receptor 1 precursor - Homo sapiens (Human) - EPHA1 gene Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. Indicus|evm.model.CM009494.1.724 Q7TQB0 TR134_MOUSE 60.256 0.883721 0.288591 Tas2r134 - Taste receptor type 2 member 134 - Mus musculus (Mouse) - Tas2r134 gene Putative taste receptor which may play a role in the perception of bitterness. Indicus|evm.model.CM009494.1.725 P59532 T2R41_MOUSE 68.197 0.993464 0.993506 Tas2r41 - Taste receptor type 2 member 41 - Mus musculus (Mouse) - Tas2r41 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Indicus|evm.model.CM009494.1.726 Q13607 OR2F1_HUMAN 54.585 0.974359 0.73817 OR2F1 - Olfactory receptor 2F1 - Homo sapiens (Human) - OR2F1 gene Odorant receptor. Indicus|evm.model.CM009494.1.727 Q8NH08 O10AC_HUMAN 82.243 0.981595 1.00308 OR10AC1 - Olfactory receptor 10AC1 - Homo sapiens (Human) - OR10AC1 gene Odorant receptor. Indicus|evm.model.CM009494.1.728 A6QLU7 TCAF2_BOVIN 82.353 0.558333 0.131291 TCAF2 - TRPM8 channel-associated factor 2 - Bos taurus (Bovine) - TCAF2 gene Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner. Indicus|evm.model.CM009494.1.729 A6QLU7 TCAF2_BOVIN 99.453 0.997814 1.00109 TCAF2 - TRPM8 channel-associated factor 2 - Bos taurus (Bovine) - TCAF2 gene Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner. Indicus|evm.model.CM009494.1.730 A5PJN5 TCAF1_BOVIN 99.783 0.997831 1.00109 TCAF1 - TRPM8 channel-associated factor 1 - Bos taurus (Bovine) - TCAF1 gene Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner. Indicus|evm.model.CM009494.1.732 Q95156 OLF3_CANLF 88.448 0.99639 0.873817 Olfactory receptor-like protein OLF3 - Canis lupus familiaris (Dog) Indicus|evm.model.CM009494.1.733 Q95156 OLF3_CANLF 65.455 0.981818 0.173502 Olfactory receptor-like protein OLF3 - Canis lupus familiaris (Dog) Indicus|evm.model.CM009494.1.735 Q6IF42 OR2A2_HUMAN 64.205 0.988701 0.556604 OR2A2 - Olfactory receptor 2A2 - Homo sapiens (Human) - OR2A2 gene Odorant receptor. Indicus|evm.model.CM009494.1.736 Q7Z4F1 LRP10_HUMAN 85.263 0.696296 0.189341 LRP10 - Low-density lipoprotein receptor-related protein 10 precursor - Homo sapiens (Human) - LRP10 gene Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). Indicus|evm.model.CM009494.1.737 Q12774 ARHG5_HUMAN 64.313 0.998074 0.975579 ARHGEF5 - Rho guanine nucleotide exchange factor 5 - Homo sapiens (Human) - ARHGEF5 gene Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). Indicus|evm.model.CM009494.1.738 O60393 NOBOX_HUMAN 60.477 0.967742 0.807525 NOBOX - Homeobox protein NOBOX - Homo sapiens (Human) - NOBOX gene Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Indicus|evm.model.CM009494.1.739 Q5E9T4 TPK1_BOVIN 100.000 0.991803 1.00412 TPK1 - Thiamin pyrophosphokinase 1 - Bos taurus (Bovine) - TPK1 gene Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate (By similarity). Indicus|evm.model.CM009494.1.741 Q9CPW0 CNTP2_MOUSE 95.742 0.997419 0.581832 Cntnap2 - Contactin-associated protein-like 2 precursor - Mus musculus (Mouse) - Cntnap2 gene Required for gap junction formation (By similarity). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons (PubMed:25378149). Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction (Probable) (PubMed:25378149). Indicus|evm.model.CM009494.1.742 Q9WTX6 CUL1_MOUSE 98.686 0.883721 1.10825 Cul1 - Cullin-1 - Mus musculus (Mouse) - Cul1 gene Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Indicus|evm.model.CM009494.1.743 Q15910 EZH2_HUMAN 98.660 0.98285 1.01609 EZH2 - Histone-lysine N-methyltransferase EZH2 - Homo sapiens (Human) - EZH2 gene Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. Indicus|evm.model.CM009494.1.744 Q29RV1 PDIA4_BOVIN 99.378 0.996894 1.00156 PDIA4 - Protein disulfide-isomerase A4 precursor - Bos taurus (Bovine) - PDIA4 gene Indicus|evm.model.CM009494.1.745 Q8N393 ZN786_HUMAN 54.867 0.997187 0.909207 ZNF786 - Zinc finger protein 786 - Homo sapiens (Human) - ZNF786 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009494.1.746 Q8TD17 ZN398_HUMAN 88.629 0.99688 0.998442 ZNF398 - Zinc finger protein 398 - Homo sapiens (Human) - ZNF398 gene Functions as a transcriptional activator. Indicus|evm.model.CM009494.1.747 Q9UDV7 ZN282_HUMAN 94.495 0.977477 0.330849 ZNF282 - Zinc finger protein 282 - Homo sapiens (Human) - ZNF282 gene Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression. Indicus|evm.model.CM009494.1.748 Q75MW2 ZN767_HUMAN 83.333 0.209979 3.10323 ZNF767P - Protein ZNF767 - Homo sapiens (Human) - ZNF767P gene Indicus|evm.model.CM009494.1.749 Q75MW2 ZN767_HUMAN 78.218 0.16835 3.83226 ZNF767P - Protein ZNF767 - Homo sapiens (Human) - ZNF767P gene Indicus|evm.model.CM009494.1.750 Q9ULD5 ZN777_HUMAN 91.707 0.997599 1.00241 ZNF777 - Zinc finger protein 777 - Homo sapiens (Human) - ZNF777 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009494.1.751 Q75MW2 ZN767_HUMAN 96.000 0.157895 4.04516 ZNF767P - Protein ZNF767 - Homo sapiens (Human) - ZNF767P gene Indicus|evm.model.CM009494.1.752 A5PL33 KRBA1_HUMAN 61.030 0.627534 1.14951 KRBA1 - Protein KRBA1 - Homo sapiens (Human) - KRBA1 gene Indicus|evm.model.CM009494.1.753 Q7Z7K2 ZN467_HUMAN 65.984 0.936681 0.769748 ZNF467 - Zinc finger protein 467 - Homo sapiens (Human) - ZNF467 gene Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity). Indicus|evm.model.CM009494.1.754 P98167 SSPO_BOVIN 99.778 0.0765827 1.14186 SSPO - SCO-spondin precursor - Bos taurus (Bovine) - SSPO gene Involved in the modulation of neuronal aggregation (PubMed:8743952). May be involved in developmental events during the formation of the central nervous system (PubMed:11008217). Indicus|evm.model.CM009494.1.755 Q2KIB5 VA0E2_BOVIN 100.000 0.197297 4.5679 ATP6V0E2 - V-type proton ATPase subunit e 2 - Bos taurus (Bovine) - ATP6V0E2 gene Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Indicus|evm.model.CM009494.1.756 Q2T9T5 LRC61_BOVIN 100.000 0.97549 0.781609 LRRC61 - Leucine-rich repeat-containing protein 61 - Bos taurus (Bovine) - LRRC61 gene Indicus|evm.model.CM009494.1.757 Q29RS5 RARR2_BOVIN 100.000 0.98773 1.00617 RARRES2 - Retinoic acid receptor responder protein 2 precursor - Bos taurus (Bovine) - RARRES2 gene Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Exhibits an antimicrobial function in the skin (By similarity). Indicus|evm.model.CM009494.1.758 Q9BWE0 REPI1_HUMAN 72.871 0.826087 0.608466 REPIN1 - Replication initiator 1 - Homo sapiens (Human) - REPIN1 gene Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending. Indicus|evm.model.CM009494.1.759 Q96BV0 ZN775_HUMAN 57.921 0.890909 0.819367 ZNF775 - Zinc finger protein 775 - Homo sapiens (Human) - ZNF775 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009494.1.760 Q8ND71 GIMA8_HUMAN 56.716 0.892809 1.10827 GIMAP8 - GTPase IMAP family member 8 - Homo sapiens (Human) - GIMAP8 gene Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. Indicus|evm.model.CM009494.1.761 Q8NHV1 GIMA7_HUMAN 62.759 0.979661 0.983333 GIMAP7 - GTPase IMAP family member 7 - Homo sapiens (Human) - GIMAP7 gene The dimer has GTPase activity; the active site contains residues from both subunits. Indicus|evm.model.CM009494.1.762 Q96F15 GIMA5_HUMAN 65.414 0.653465 1.31596 GIMAP5 - GTPase IMAP family member 5 - Homo sapiens (Human) - GIMAP5 gene Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Indicus|evm.model.CM009494.1.763 Q8NHV1 GIMA7_HUMAN 63.390 0.986577 0.993333 GIMAP7 - GTPase IMAP family member 7 - Homo sapiens (Human) - GIMAP7 gene The dimer has GTPase activity; the active site contains residues from both subunits. Indicus|evm.model.CM009494.1.764 Q0V8E4 ASND1_BOVIN 88.194 0.915584 0.240625 ASNSD1 - Asparagine synthetase domain-containing protein 1 - Bos taurus (Bovine) - ASNSD1 gene Indicus|evm.model.CM009494.1.765 Q9NUV9 GIMA4_HUMAN 61.180 0.978125 0.972644 GIMAP4 - GTPase IMAP family member 4 - Homo sapiens (Human) - GIMAP4 gene During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. Indicus|evm.model.CM009494.1.767 Q8NHV1 GIMA7_HUMAN 65.411 0.989796 0.98 GIMAP7 - GTPase IMAP family member 7 - Homo sapiens (Human) - GIMAP7 gene The dimer has GTPase activity; the active site contains residues from both subunits. Indicus|evm.model.CM009494.1.768 Q8NHV1 GIMA7_HUMAN 54.828 0.981061 0.88 GIMAP7 - GTPase IMAP family member 7 - Homo sapiens (Human) - GIMAP7 gene The dimer has GTPase activity; the active site contains residues from both subunits. Indicus|evm.model.CM009494.1.769 Q8WWP7 GIMA1_HUMAN 62.319 0.925424 0.964052 GIMAP1 - GTPase IMAP family member 1 - Homo sapiens (Human) - GIMAP1 gene May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). Indicus|evm.model.CM009494.1.770 Q9NUV9 GIMA4_HUMAN 60.317 0.9653 0.963526 GIMAP4 - GTPase IMAP family member 4 - Homo sapiens (Human) - GIMAP4 gene During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. Indicus|evm.model.CM009494.1.771 A5PKB7 GIMA6_BOVIN 84.674 0.980695 0.759531 GIMAP6 - GTPase IMAP family member 6 - Bos taurus (Bovine) - GIMAP6 gene cytosol Indicus|evm.model.CM009494.1.772 Q8NHV1 GIMA7_HUMAN 64.407 0.986577 0.993333 GIMAP7 - GTPase IMAP family member 7 - Homo sapiens (Human) - GIMAP7 gene The dimer has GTPase activity; the active site contains residues from both subunits. Indicus|evm.model.CM009494.1.773 Q9UG22 GIMA2_HUMAN 66.393 0.263043 1.36499 GIMAP2 - GTPase IMAP family member 2 - Homo sapiens (Human) - GIMAP2 gene The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. Indicus|evm.model.CM009494.1.774 Q96F15 GIMA5_HUMAN 63.356 0.941748 1.00651 GIMAP5 - GTPase IMAP family member 5 - Homo sapiens (Human) - GIMAP5 gene Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Indicus|evm.model.CM009494.1.775 Q8BWF2 GIMA5_MOUSE 59.449 0.821429 1 Gimap5 - GTPase IMAP family member 5 - Mus musculus (Mouse) - Gimap5 gene Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (PubMed:16509771). Inhibitor of GSK3A. May act by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of bone marrow hematopoietic stem cells, as well as of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (PubMed:18796632, PubMed:21502331). May promote the survival of mature T lymphocytes upon cytokine withdrawal (PubMed:16509771). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (PubMed:25808953). Indicus|evm.model.CM009494.1.776 Q5R8D6 T176B_PONAB 66.052 0.616822 1.58519 TMEM176B - Transmembrane protein 176B - Pongo abelii (Sumatran orangutan) - TMEM176B gene May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). Indicus|evm.model.CM009494.1.777 Q7YQI4 T176A_BOVIN 99.585 0.991736 1.00415 TMEM176A - Transmembrane protein 176A - Bos taurus (Bovine) - TMEM176A gene negative regulation of dendritic cell differentiation Indicus|evm.model.CM009494.1.778 Q9TRC7 AOC1_PIG 84.952 0.965608 1.00132 AOC1 - Amiloride-sensitive amine oxidase [copper-containing] precursor - Sus scrofa (Pig) - AOC1 gene Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Indicus|evm.model.CM009494.1.779 Q12809 KCNH2_HUMAN 95.604 0.864813 0.899914 KCNH2 - Potassium voltage-gated channel subfamily H member 2 - Homo sapiens (Human) - KCNH2 gene Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661). Indicus|evm.model.CM009494.1.780 P29473 NOS3_BOVIN 98.008 0.998309 0.981743 NOS3 - Nitric oxide synthase, endothelial - Bos taurus (Bovine) - NOS3 gene Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Indicus|evm.model.CM009494.1.781 Q6EBV9 ATG9B_MOUSE 83.529 0.413709 0.886117 Atg9b - Autophagy-related protein 9B - Mus musculus (Mouse) - Atg9b gene Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Indicus|evm.model.CM009494.1.782 Q5RFQ9 MITOS_PONAB 87.679 0.97619 0.994429 ABCB8 - Mitochondrial potassium channel ATP-binding subunit precursor - Pongo abelii (Sumatran orangutan) - ABCB8 gene ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane. Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (By similarity). Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity). Indicus|evm.model.CM009494.1.783 Q9UHC3 ASIC3_HUMAN 83.459 0.996248 1.00377 ASIC3 - Acid-sensing ion channel 3 - Homo sapiens (Human) - ASIC3 gene Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Indicus|evm.model.CM009494.1.784 P49615 CDK5_MOUSE 92.123 0.99278 0.94863 Cdk5 - Cyclin-dependent-like kinase 5 - Mus musculus (Mouse) - Cdk5 gene Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. Indicus|evm.model.CM009494.1.785 Q6SJP2 B3A2_HORSE 96.207 0.998387 1.00243 SLC4A2 - Anion exchange protein 2 - Equus caballus (Horse) - SLC4A2 gene Plasma membrane anion exchange protein of wide distribution. Indicus|evm.model.CM009494.1.786 Q14296 FASTK_HUMAN 90.727 0.996324 0.990893 FASTK - Fas-activated serine/threonine kinase - Homo sapiens (Human) - FASTK gene Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. Indicus|evm.model.CM009494.1.787 Q3ZBI9 TMUB1_BOVIN 100.000 0.830508 1.19919 TMUB1 - Transmembrane and ubiquitin-like domain-containing protein 1 - Bos taurus (Bovine) - TMUB1 gene Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface. Acts as negative regulator of hepatocyte growth during regeneration. Indicus|evm.model.CM009494.1.788 Q8VHH5 AGAP3_MOUSE 100.000 0.254386 0.250549 Agap3 - Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 - Mus musculus (Mouse) - Agap3 gene GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. Indicus|evm.model.CM009494.1.789 P99027 RLA2_MOUSE 54.545 0.698925 0.808696 Rplp2 - 60S acidic ribosomal protein P2 - Mus musculus (Mouse) - Rplp2 gene Plays an important role in the elongation step of protein synthesis. Indicus|evm.model.CM009494.1.790 Q96P47 AGAP3_HUMAN 89.571 0.966467 0.954286 AGAP3 - Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 - Homo sapiens (Human) - AGAP3 gene GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. Indicus|evm.model.CM009494.1.791 Q14549 GBX1_HUMAN 92.632 0.917073 0.564738 GBX1 - Homeobox protein GBX-1 - Homo sapiens (Human) - GBX1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, regulation of nervous system development, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009494.1.792 Q14549 GBX1_HUMAN 91.176 0.585799 0.465565 GBX1 - Homeobox protein GBX-1 - Homo sapiens (Human) - GBX1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, regulation of nervous system development, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009494.1.793 Q8WXI3 ASB10_HUMAN 88.478 0.91018 1.07281 ASB10 - Ankyrin repeat and SOCS box protein 10 - Homo sapiens (Human) - ASB10 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009494.1.794 A0A2R8Y619 H2BE1_HUMAN 88.525 0.128998 7.68852 H2BE1 - Histone H2B type 2-E1 - Homo sapiens (Human) - H2BE1 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009494.1.795 Q2KJA2 ABCF2_BOVIN 100.000 0.996805 1.0016 ABCF2 - ATP-binding cassette sub-family F member 2 - Bos taurus (Bovine) - ABCF2 gene ATP binding Indicus|evm.model.CM009494.1.796 Q9P2E5 CHPF2_HUMAN 95.424 0.95232 1.00518 CHPF2 - Chondroitin sulfate glucuronyltransferase - Homo sapiens (Human) - CHPF2 gene Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity. Indicus|evm.model.CM009494.1.797 Q6STE5 SMRD3_HUMAN 99.125 0.968153 0.975155 SMARCD3 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 - Homo sapiens (Human) - SMARCD3 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Indicus|evm.model.CM009494.1.798 Q8MJ87 NUB1_BOVIN 100.000 0.344288 2.8914 NUB1 - NEDD8 ultimate buster 1 - Bos taurus (Bovine) - NUB1 gene Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8 and its conjugates to the proteasome for degradation (By similarity). Indicus|evm.model.CM009494.1.799 Q86TI4 WDR86_HUMAN 89.752 0.66879 1.25266 WDR86 - WD repeat-containing protein 86 - Homo sapiens (Human) - WDR86 gene Indicus|evm.model.CM009494.1.800 D3ZEG1 CRGN_RAT 92.857 0.989071 1 Crygn - Gamma-crystallin N - Rattus norvegicus (Rat) - Crygn gene Crystallins are the dominant structural components of the vertebrate eye lens. Plays also an important role for integrity and function of auditory nuclei. Indicus|evm.model.CM009494.1.801 Q62639 RHEB_RAT 96.552 0.864322 1.08152 Rheb - GTP-binding protein Rheb precursor - Rattus norvegicus (Rat) - Rheb gene Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Indicus|evm.model.CM009494.1.803 Q9UGJ0 AAKG2_HUMAN 97.785 0.984375 0.56239 PRKAG2 - 5'-AMP-activated protein kinase subunit gamma-2 - Homo sapiens (Human) - PRKAG2 gene AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. Indicus|evm.model.CM009494.1.805 Q91WG5 AAKG2_MOUSE 90.000 0.613169 0.429329 Prkag2 - 5'-AMP-activated protein kinase subunit gamma-2 - Mus musculus (Mouse) - Prkag2 gene AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity). Indicus|evm.model.CM009494.1.806 Q95JX4 GLTL5_MACFA 68.904 0.986637 1.01354 GALNTL5 - Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 - Macaca fascicularis (Crab-eating macaque) - GALNTL5 gene Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region (By similarity). Indicus|evm.model.CM009494.1.807 Q8NCW6 GLT11_HUMAN 92.422 0.995058 0.998355 GALNT11 - Polypeptide N-acetylgalactosaminyltransferase 11 - Homo sapiens (Human) - GALNT11 gene Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). Indicus|evm.model.CM009494.1.808 Q8NEZ4 KMT2C_HUMAN 82.119 0.999592 0.997964 KMT2C - Histone-lysine N-methyltransferase 2C - Homo sapiens (Human) - KMT2C gene Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. Indicus|evm.model.CM009494.1.809 A6NM43 TCPQL_HUMAN 73.004 0.813084 0.576302 CCT8L1P - Putative T-complex protein 1 subunit theta-like 1 - Homo sapiens (Human) - CCT8L1P gene Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Indicus|evm.model.CM009494.1.810 O43543 XRCC2_HUMAN 84.643 0.992883 1.00357 XRCC2 - DNA repair protein XRCC2 - Homo sapiens (Human) - XRCC2 gene Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Indicus|evm.model.CM009494.1.811 Q9P1U1 ARP3B_HUMAN 95.433 0.976471 1.01675 ACTR3B - Actin-related protein 3B - Homo sapiens (Human) - ACTR3B gene Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. Indicus|evm.model.CM009494.1.812 Q58DW0 RL4_BOVIN 62.500 0.977011 0.206161 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Indicus|evm.model.CM009494.1.813 Q58DW0 RL4_BOVIN 78.462 0.969697 0.156398 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Indicus|evm.model.CM009494.1.814 Q3ZCH9 HDHD2_BOVIN 93.243 0.973333 0.289575 HDHD2 - Haloacid dehalogenase-like hydrolase domain-containing protein 2 - Bos taurus (Bovine) - HDHD2 gene enzyme binding, phosphatase activity, dephosphorylation Indicus|evm.model.CM009494.1.815 Q3ZCB6 PPDPF_BOVIN 86.726 0.965517 1 PPDPF - Pancreatic progenitor cell differentiation and proliferation factor - Bos taurus (Bovine) - PPDPF gene Probable regulator of exocrine pancreas development. Indicus|evm.model.CM009494.1.818 P42659 DPP6_BOVIN 99.582 0.279015 0.988413 DPP6 - Dipeptidyl aminopeptidase-like protein 6 - Bos taurus (Bovine) - DPP6 gene Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity. Indicus|evm.model.CM009494.1.819 A0JNA8 PAXI1_BOVIN 98.861 0.868317 1.02642 PAXIP1 - PAX-interacting protein 1 - Bos taurus (Bovine) - PAXIP1 gene Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity). Indicus|evm.model.CM009494.1.820 A0JNC3 INSI1_BOVIN 99.638 0.99278 1.00362 INSIG1 - Insulin-induced gene 1 protein - Bos taurus (Bovine) - INSIG1 gene Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139. Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78. Indicus|evm.model.CM009494.1.821 P19622 HME2_HUMAN 100.000 0.879121 0.273273 EN2 - Homeobox protein engrailed-2 - Homo sapiens (Human) - EN2 gene chromatin, fibrillar center, nucleolus, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, multicellular organism development, neuron differentiation Indicus|evm.model.CM009494.1.823 Q3B7I2 CNPY1_HUMAN 84.146 0.27931 3.15217 CNPY1 - Protein canopy homolog 1 - Homo sapiens (Human) - CNPY1 gene endoplasmic reticulum Indicus|evm.model.CM009494.1.826 Q96EV2 RBM33_HUMAN 91.711 0.477929 1.00684 RBM33 - RNA-binding protein 33 - Homo sapiens (Human) - RBM33 gene RNA binding Indicus|evm.model.CM009494.1.827 Q15465 SHH_HUMAN 97.326 0.834081 0.482684 SHH - Sonic hedgehog protein precursor - Homo sapiens (Human) - SHH gene The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). Indicus|evm.model.CM009494.1.837 Q2T9W6 LRRF2_BOVIN 97.183 0.875 0.2 LRRFIP2 - Leucine-rich repeat flightless-interacting protein 2 - Bos taurus (Bovine) - LRRFIP2 gene May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity). Indicus|evm.model.CM009494.1.839 Q9H0A6 RNF32_HUMAN 69.315 0.994065 0.930939 RNF32 - RING finger protein 32 - Homo sapiens (Human) - RNF32 gene May play a role in sperm formation. Indicus|evm.model.CM009494.1.840 Q8WVP7 LMBR1_HUMAN 88.367 0.995614 0.930612 LMBR1 - Limb region 1 protein homolog - Homo sapiens (Human) - LMBR1 gene Putative membrane receptor. Indicus|evm.model.CM009494.1.841 Q5C9Z4 NOM1_HUMAN 74.561 0.964183 0.811628 NOM1 - Nucleolar MIF4G domain-containing protein 1 - Homo sapiens (Human) - NOM1 gene Plays a role in targeting PPP1CA to the nucleolus. Indicus|evm.model.CM009494.1.842 P50219 MNX1_HUMAN 86.413 0.989189 0.461347 MNX1 - Motor neuron and pancreas homeobox protein 1 - Homo sapiens (Human) - MNX1 gene Putative transcription factor involved in pancreas development and function. Indicus|evm.model.CM009494.1.843 Q15386 UBE3C_HUMAN 93.242 0.949721 0.99169 UBE3C - Ubiquitin-protein ligase E3C - Homo sapiens (Human) - UBE3C gene E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. Indicus|evm.model.CM009494.1.844 Q0III6 DNJB6_BOVIN 99.587 0.99177 1.00413 DNAJB6 - DnaJ homolog subfamily B member 6 - Bos taurus (Bovine) - DNAJB6 gene Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). Indicus|evm.model.CM009494.1.847 Q92932 PTPR2_HUMAN 86.572 0.4125 0.630542 PTPRN2 - Receptor-type tyrosine-protein phosphatase N2 precursor - Homo sapiens (Human) - PTPRN2 gene Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). Indicus|evm.model.CM009494.1.849 P80560 PTPR2_MOUSE 65.753 0.238411 0.301698 Ptprn2 - Receptor-type tyrosine-protein phosphatase N2 precursor - Mus musculus (Mouse) - Ptprn2 gene Plays a role in vesicle-mediated secretory processes (PubMed:21732083). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:21732083). Plays a role in insulin secretion in response to glucose stimuli (PubMed:15220191, PubMed:16418280, PubMed:21732083). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463). Required to maintain normal levels of renin expression and renin release (PubMed:19019914). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (By similarity). Indicus|evm.model.CM009494.1.859 P80560 PTPR2_MOUSE 48.276 0.50266 0.375624 Ptprn2 - Receptor-type tyrosine-protein phosphatase N2 precursor - Mus musculus (Mouse) - Ptprn2 gene Plays a role in vesicle-mediated secretory processes (PubMed:21732083). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:21732083). Plays a role in insulin secretion in response to glucose stimuli (PubMed:15220191, PubMed:16418280, PubMed:21732083). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463). Required to maintain normal levels of renin expression and renin release (PubMed:19019914). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (By similarity). Indicus|evm.model.CM009494.1.860 Q92932 PTPR2_HUMAN 57.519 0.467857 0.551724 PTPRN2 - Receptor-type tyrosine-protein phosphatase N2 precursor - Homo sapiens (Human) - PTPRN2 gene Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). Indicus|evm.model.CM009494.1.863 Q86XI2 CNDG2_HUMAN 81.277 0.998247 0.99825 NCAPG2 - Condensin-2 complex subunit G2 - Homo sapiens (Human) - NCAPG2 gene Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Indicus|evm.model.CM009494.1.864 Q3TZZ7 ESYT2_MOUSE 90.865 0.984597 0.998817 Esyt2 - Extended synaptotagmin-2 - Mus musculus (Mouse) - Esyt2 gene Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex (By similarity). Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (By similarity). Indicus|evm.model.CM009494.1.865 Q8WVS4 DC2I1_HUMAN 72.810 0.648258 1.10413 DYNC2I1 - Cytoplasmic dynein 2 intermediate chain 1 - Homo sapiens (Human) - DYNC2I1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:23910462, PubMed:25205765, PubMed:31451806, PubMed:29742051). DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella (PubMed:29742051, PubMed:30320547, PubMed:30649997). Requires also to maintain a functional transition zone (PubMed:30320547). Indicus|evm.model.CM009494.1.866 P41587 VIPR2_HUMAN 82.377 0.731928 0.757991 VIPR2 - Vasoactive intestinal polypeptide receptor 2 precursor - Homo sapiens (Human) - VIPR2 gene This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. Indicus|evm.model.CM009494.1.867 Q2HJG5 VPS35_BOVIN 82.353 0.144708 0.581658 VPS35 - Vacuolar protein sorting-associated protein 35 - Bos taurus (Bovine) - VPS35 gene Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for endosomal localization of WASHC2. Mediates the association of the CSC with the WASH complex via WASHC2. Required for the endosomal localization of TBC1D5 (By similarity). Indicus|evm.model.CM009494.1.868 D6RBQ6 U17LH_HUMAN 52.991 0.986985 0.869811 USP17L17 - Ubiquitin carboxyl-terminal hydrolase 17-like protein 17 - Homo sapiens (Human) - USP17L17 gene Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. Indicus|evm.model.CM009495.1.1 Q2T9M4 DRC7_BOVIN 92.453 0.684211 0.087156 DRC7 - Dynein regulatory complex subunit 7 - Bos taurus (Bovine) - DRC7 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility. Indicus|evm.model.CM009495.1.2 Q9BQI4 CCDC3_HUMAN 93.333 0.235294 0.692593 CCDC3 - Coiled-coil domain-containing protein 3 precursor - Homo sapiens (Human) - CCDC3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity). Indicus|evm.model.CM009495.1.4 A2RUR9 C144A_HUMAN 46.835 0.428571 0.12754 CCDC144A - Coiled-coil domain-containing protein 144A - Homo sapiens (Human) - CCDC144A gene Indicus|evm.model.CM009495.1.5 Q8IYA2 C144C_HUMAN 49.034 0.336088 0.880356 CCDC144CP - Putative coiled-coil domain-containing protein 144C - Homo sapiens (Human) - CCDC144CP gene Indicus|evm.model.CM009495.1.6 Q61086 FZD3_MOUSE 94.872 0.174603 0.662162 Fzd3 - Frizzled-3 precursor - Mus musculus (Mouse) - Fzd3 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner. Indicus|evm.model.CM009495.1.7 Q61086 FZD3_MOUSE 92.308 0.97931 0.217718 Fzd3 - Frizzled-3 precursor - Mus musculus (Mouse) - Fzd3 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner. Indicus|evm.model.CM009495.1.9 Q8IX29 FBX16_HUMAN 83.626 0.721739 0.787671 FBXO16 - F-box only protein 16 - Homo sapiens (Human) - FBXO16 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Indicus|evm.model.CM009495.1.10 Q2KIS9 TSN8_BOVIN 99.580 0.991632 1.0042 TSPAN8 - Tetraspanin-8 - Bos taurus (Bovine) - TSPAN8 gene integral component of plasma membrane Indicus|evm.model.CM009495.1.11 F1MT22 LGR5_BOVIN 97.354 0.997738 0.974642 LGR5 - Leucine-rich repeat-containing G-protein coupled receptor 5 precursor - Bos taurus (Bovine) - LGR5 gene Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development (By similarity). Indicus|evm.model.CM009495.1.12 O60293 ZC3H1_HUMAN 95.123 0.998994 1 ZFC3H1 - Zinc finger C3H1 domain-containing protein - Homo sapiens (Human) - ZFC3H1 gene Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. Indicus|evm.model.CM009495.1.13 Q9H0W7 THAP2_HUMAN 93.868 0.954751 0.969298 THAP2 - THAP domain-containing protein 2 - Homo sapiens (Human) - THAP2 gene nucleolus, nucleus Indicus|evm.model.CM009495.1.14 Q5RF73 TMM19_PONAB 88.955 0.991098 1.00298 TMEM19 - Transmembrane protein 19 - Pongo abelii (Sumatran orangutan) - TMEM19 gene Indicus|evm.model.CM009495.1.15 Q17R06 RAB21_BOVIN 96.815 0.917647 0.765766 RAB21 - Ras-related protein Rab-21 precursor - Bos taurus (Bovine) - RAB21 gene Small GTPase involved in membrane trafficking control (By similarity). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity). Indicus|evm.model.CM009495.1.16 Q8TC07 TBC15_HUMAN 94.790 0.99711 1.00145 TBC1D15 - TBC1 domain family member 15 - Homo sapiens (Human) - TBC1D15 gene Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). Indicus|evm.model.CM009495.1.17 Q2HZ26 TPH2_MACMU 87.138 0.993174 0.597959 TPH2 - Tryptophan 5-hydroxylase 2 - Macaca mulatta (Rhesus macaque) - TPH2 gene neuron projection, tryptophan 5-monooxygenase activity Indicus|evm.model.CM009495.1.18 Q8IWU9 TPH2_HUMAN 97.826 0.73262 0.381633 TPH2 - Tryptophan 5-hydroxylase 2 - Homo sapiens (Human) - TPH2 gene cytosol, neuron projection, tryptophan 5-monooxygenase activity, indolalkylamine biosynthetic process Indicus|evm.model.CM009495.1.20 Q9UKU6 TRHDE_HUMAN 90.652 0.789238 0.435547 TRHDE - Thyrotropin-releasing hormone-degrading ectoenzyme - Homo sapiens (Human) - TRHDE gene Specific inactivation of TRH after its release. Indicus|evm.model.CM009495.1.21 Q9UKU6 TRHDE_HUMAN 98.574 0.961774 0.638672 TRHDE - Thyrotropin-releasing hormone-degrading ectoenzyme - Homo sapiens (Human) - TRHDE gene Specific inactivation of TRH after its release. Indicus|evm.model.CM009495.1.22 Q96GX2 A7L3B_HUMAN 97.938 0.979592 1.01031 ATXN7L3B - Ataxin-7-like protein 3B - Homo sapiens (Human) - ATXN7L3B gene By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3. Indicus|evm.model.CM009495.1.23 Q5JST6 EFHC2_HUMAN 73.214 0.979899 0.531375 EFHC2 - EF-hand domain-containing family member C2 - Homo sapiens (Human) - EFHC2 gene axoneme, ciliary basal body, mitotic spindle, alpha-tubulin binding, cilium-dependent cell motility, mitotic cytokinesis, mitotic spindle organization, regulation of neuron projection development Indicus|evm.model.CM009495.1.24 Q96PR1 KCNC2_HUMAN 96.837 0.936073 0.68652 KCNC2 - Potassium voltage-gated channel subfamily C member 2 - Homo sapiens (Human) - KCNC2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity). Indicus|evm.model.CM009495.1.25 Q9GKR6 CAYP2_MACFA 79.872 0.574861 1.72843 CAPS2 - Calcyphosin-2 - Macaca fascicularis (Crab-eating macaque) - CAPS2 gene Indicus|evm.model.CM009495.1.26 Q32LB5 GPRL1_BOVIN 100.000 0.991736 1.00415 GLIPR1L1 - GLIPR1-like protein 1 precursor - Bos taurus (Bovine) - GLIPR1L1 gene Plays a role in the binding between sperm and oocytes (PubMed:22552861). Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation (PubMed:23785420). Also component of the CD9-positive microvesicules found in the cauda region (PubMed:23785420). Indicus|evm.model.CM009495.1.27 Q4G1C9 GRPL2_HUMAN 71.875 0.734615 0.755814 GLIPR1L2 - GLIPR1-like protein 2 - Homo sapiens (Human) - GLIPR1L2 gene extracellular space, binding of sperm to zona pellucida Indicus|evm.model.CM009495.1.28 P48060 GLIP1_HUMAN 79.286 0.668269 0.781955 GLIPR1 - Glioma pathogenesis-related protein 1 precursor - Homo sapiens (Human) - GLIPR1 gene azurophil granule membrane, extracellular space, membrane, plasma membrane, neutrophil degranulation, regulation of metabolic process Indicus|evm.model.CM009495.1.29 Q3B7L9 KRR1_BOVIN 100.000 0.994778 1.00262 KRR1 - KRR1 small subunit processome component homolog - Bos taurus (Bovine) - KRR1 gene Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). Indicus|evm.model.CM009495.1.30 Q8WV24 PHLA1_HUMAN 91.304 0.744949 0.987531 PHLDA1 - Pleckstrin homology-like domain family A member 1 - Homo sapiens (Human) - PHLDA1 gene Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. Indicus|evm.model.CM009495.1.31 A6H767 NP1L1_BOVIN 100.000 0.958231 1.04092 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009495.1.32 Q8TAM1 BBS10_HUMAN 73.232 0.99723 0.998617 BBS10 - Bardet-Biedl syndrome 10 protein - Homo sapiens (Human) - BBS10 gene Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). Involved in adipogenic differentiation (PubMed:19190184). Indicus|evm.model.CM009495.1.33 Q9BZF1 OSBL8_HUMAN 95.565 0.997785 1.01575 OSBPL8 - Oxysterol-binding protein-related protein 8 - Homo sapiens (Human) - OSBPL8 gene Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). Indicus|evm.model.CM009495.1.34 Q8IUH5 ZDH17_HUMAN 97.152 0.996785 0.984177 ZDHHC17 - Palmitoyltransferase ZDHHC17 - Homo sapiens (Human) - ZDHHC17 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (PubMed:24705354). Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Indicus|evm.model.CM009495.1.35 Q16527 CSRP2_HUMAN 100.000 0.989691 1.00518 CSRP2 - Cysteine and glycine-rich protein 2 - Homo sapiens (Human) - CSRP2 gene Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system. Indicus|evm.model.CM009495.1.36 E1BE02 E2F7_BOVIN 99.561 0.997802 0.998902 E2F7 - Transcription factor E2F7 - Bos taurus (Bovine) - E2F7 gene Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation (By similarity). Indicus|evm.model.CM009495.1.38 Q8IVL0 NAV3_HUMAN 94.148 0.98062 0.973585 NAV3 - Neuron navigator 3 - Homo sapiens (Human) - NAV3 gene May regulate IL2 production by T-cells. May be involved in neuron regeneration. Indicus|evm.model.CM009495.1.40 Q0V8N6 P3_BOVIN 95.775 0.859756 0.343816 SLC10A3 - P3 protein - Bos taurus (Bovine) - SLC10A3 gene The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions. Indicus|evm.model.CM009495.1.41 P48018 SYT1_BOVIN 100.000 0.715986 1.39336 SYT1 - Synaptotagmin-1 - Bos taurus (Bovine) - SYT1 gene Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity). Indicus|evm.model.CM009495.1.42 Q96IZ0 PAWR_HUMAN 96.970 0.580357 0.329412 PAWR - PRKC apoptosis WT1 regulator protein - Homo sapiens (Human) - PAWR gene Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. Indicus|evm.model.CM009495.1.43 Q96IZ0 PAWR_HUMAN 94.737 0.420455 0.258824 PAWR - PRKC apoptosis WT1 regulator protein - Homo sapiens (Human) - PAWR gene Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. Indicus|evm.model.CM009495.1.44 O14974 MYPT1_HUMAN 95.441 0.941011 1.03689 PPP1R12A - Protein phosphatase 1 regulatory subunit 12A - Homo sapiens (Human) - PPP1R12A gene Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. Indicus|evm.model.CM009495.1.45 Q3ZCN5 OTOGL_HUMAN 90.082 0.969341 1.02101 OTOGL - Otogelin-like protein precursor - Homo sapiens (Human) - OTOGL gene extracellular matrix, extracellular space Indicus|evm.model.CM009495.1.46 O15480 MAGB3_HUMAN 73.381 0.831325 0.479769 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Indicus|evm.model.CM009495.1.47 Q9UMZ3 PTPRQ_HUMAN 90.184 0.69078 1.4464 PTPRQ - Phosphatidylinositol phosphatase PTPRQ precursor - Homo sapiens (Human) - PTPRQ gene Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells. Indicus|evm.model.CM009495.1.48 Q7YS80 MYF6_BOVIN 100.000 0.99177 1.00413 MYF6 - Myogenic factor 6 - Bos taurus (Bovine) - MYF6 gene Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). Indicus|evm.model.CM009495.1.49 P17667 MYF5_BOVIN 99.608 0.992188 1.00392 MYF5 - Myogenic factor 5 - Bos taurus (Bovine) - MYF5 gene Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). Indicus|evm.model.CM009495.1.50 O14910 LIN7A_HUMAN 100.000 0.991453 1.00429 LIN7A - Protein lin-7 homolog A - Homo sapiens (Human) - LIN7A gene Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Indicus|evm.model.CM009495.1.51 A7MB45 ACSS3_BOVIN 99.825 0.998252 0.833819 ACSS3 - Acyl-CoA synthetase short-chain family member 3, mitochondrial precursor - Bos taurus (Bovine) - ACSS3 gene Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (By similarity). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity. Indicus|evm.model.CM009495.1.52 O75334 LIPA2_HUMAN 99.523 0.99841 1.0008 PPFIA2 - Liprin-alpha-2 - Homo sapiens (Human) - PPFIA2 gene Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). Indicus|evm.model.CM009495.1.53 A5PJN1 TAP26_BOVIN 100.000 0.991736 1.00415 CCDC59 - Thyroid transcription factor 1-associated protein 26 - Bos taurus (Bovine) - CCDC59 gene Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities (By similarity). Indicus|evm.model.CM009495.1.54 Q8N6Q8 MET25_HUMAN 92.727 0.222449 0.812604 METTL25 - Methyltransferase-like protein 25 - Homo sapiens (Human) - METTL25 gene Putative methyltransferase. Indicus|evm.model.CM009495.1.55 Q8N394 TMTC2_HUMAN 96.139 0.920522 1.00837 TMTC2 - Protein O-mannosyl-transferase TMTC2 - Homo sapiens (Human) - TMTC2 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Indicus|evm.model.CM009495.1.56 Q2KIT1 PKRI1_BOVIN 97.849 0.989305 1.00538 PRKRIP1 - PRKR-interacting protein 1 - Bos taurus (Bovine) - PRKRIP1 gene Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity). Indicus|evm.model.CM009495.1.57 Q8IZY2 ABCA7_HUMAN 72.881 0.72 0.0349487 ABCA7 - Phospholipid-transporting ATPase ABCA7 - Homo sapiens (Human) - ABCA7 gene Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). Indicus|evm.model.CM009495.1.58 Q9XS59 S6A15_BOVIN 100.000 0.99726 1.00137 SLC6A15 - Sodium-dependent neutral amino acid transporter B(0)AT2 - Bos taurus (Bovine) - SLC6A15 gene Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched-chain amino acids, particularly leucine, valine and isoleucine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. Indicus|evm.model.CM009495.1.59 P0C672 TSN19_HUMAN 74.494 0.601467 1.64919 TSPAN19 - Tetraspanin-19 - Homo sapiens (Human) - TSPAN19 gene integral component of plasma membrane Indicus|evm.model.CM009495.1.60 Q96JM4 LRIQ1_HUMAN 68.568 0.968263 0.969803 LRRIQ1 - Leucine-rich repeat and IQ domain-containing protein 1 - Homo sapiens (Human) - LRRIQ1 gene Indicus|evm.model.CM009495.1.62 Q15699 ALX1_HUMAN 98.466 0.993884 1.00307 ALX1 - ALX homeobox protein 1 - Homo sapiens (Human) - ALX1 gene Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:9753625, PubMed:8756334). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). Indicus|evm.model.CM009495.1.63 O75901 RASF9_HUMAN 91.546 0.995181 0.954023 RASSF9 - Ras association domain-containing protein 9 - Homo sapiens (Human) - RASSF9 gene May play a role in regulating vesicuar trafficking in cells. Indicus|evm.model.CM009495.1.64 P01156 NEUT_BOVIN 100.000 0.988304 1.00588 NTS - Neurotensin/neuromedin N precursor - Bos taurus (Bovine) - NTS gene Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle. Indicus|evm.model.CM009495.1.65 Q6ITT3 MGT4C_PIG 91.632 0.995825 1.00209 MGAT4C - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C - Sus scrofa (Pig) - MGAT4C gene Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity). Indicus|evm.model.CM009495.1.66 Q5E995 RS6_BOVIN 76.887 0.994792 0.771084 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009495.1.67 Q32L99 PTGR2_BOVIN 86.895 0.993711 0.905983 PTGR2 - Prostaglandin reductase 2 - Bos taurus (Bovine) - PTGR2 gene Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Indicus|evm.model.CM009495.1.68 Q32KY7 CL050_BOVIN 86.311 0.899582 1.27467 Uncharacterized protein C12orf50 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.69 Q2KJ69 CL029_BOVIN 99.385 0.993865 1.00308 Uncharacterized protein C12orf29 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.70 Q9TU23 CE290_BOVIN 99.847 0.528698 1.68529 CEP290 - Centrosomal protein of 290 kDa - Bos taurus (Bovine) - CEP290 gene Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. Required for efficient recruitment of RAB8A to primary cilium. In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5. Activates ATF4-mediated transcription. Indicus|evm.model.CM009495.1.71 Q6ZXV5 TMTC3_HUMAN 93.122 0.994559 1.00437 TMTC3 - Protein O-mannosyl-transferase TMTC3 - Homo sapiens (Human) - TMTC3 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3 (PubMed:28973932). Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. Indicus|evm.model.CM009495.1.72 Q28132 SCF_BOVIN 100.000 0.992727 1.00365 KITLG - Kit ligand precursor - Bos taurus (Bovine) - KITLG gene Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity). Indicus|evm.model.CM009495.1.76 A5GFQ0 RL7L_PIG 73.973 0.986301 0.295547 RPL7L1 - 60S ribosomal protein L7-like 1 - Sus scrofa (Pig) - RPL7L1 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009495.1.77 A5GFQ0 RL7L_PIG 45.946 0.980952 0.425101 RPL7L1 - 60S ribosomal protein L7-like 1 - Sus scrofa (Pig) - RPL7L1 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009495.1.78 Q2KJ36 DUS6_BOVIN 100.000 0.994764 1.00262 DUSP6 - Dual specificity protein phosphatase 6 - Bos taurus (Bovine) - DUSP6 gene Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Indicus|evm.model.CM009495.1.80 Q8TC44 POC1B_HUMAN 89.727 0.993737 1.00209 POC1B - POC1 centriolar protein homolog B - Homo sapiens (Human) - POC1B gene Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567, PubMed:32060285). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation (PubMed:32060285). Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). Indicus|evm.model.CM009495.1.81 P23220 AT2B1_PIG 99.180 0.998362 1.00082 ATP2B1 - Plasma membrane calcium-transporting ATPase 1 - Sus scrofa (Pig) - ATP2B1 gene Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. Indicus|evm.model.CM009495.1.83 Q2T9P9 CCER1_BOVIN 100.000 0.995192 1.00241 CCER1 - Coiled-coil domain-containing glutamate-rich protein 1 - Bos taurus (Bovine) - CCER1 gene Indicus|evm.model.CM009495.1.84 P79119 EPYC_BOVIN 100.000 0.993789 1.00312 EPYC - Epiphycan precursor - Bos taurus (Bovine) - EPYC gene May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization. Indicus|evm.model.CM009495.1.85 O62702 KERA_BOVIN 99.716 0.994334 1.00284 KERA - Keratocan precursor - Bos taurus (Bovine) - KERA gene May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. Indicus|evm.model.CM009495.1.86 Q05443 LUM_BOVIN 100.000 0.994169 1.00292 LUM - Lumican precursor - Bos taurus (Bovine) - LUM gene extracellular matrix, extracellular space, collagen binding Indicus|evm.model.CM009495.1.87 P21793 PGS2_BOVIN 100.000 0.99446 1.00278 DCN - Decorin precursor - Bos taurus (Bovine) - DCN gene May affect the rate of fibrils formation. Indicus|evm.model.CM009495.1.88 P53348 BTG1_BOVIN 100.000 0.988372 1.00585 BTG1 - Protein BTG1 - Bos taurus (Bovine) - BTG1 gene Anti-proliferative protein. Indicus|evm.model.CM009495.1.89 Q5RCP8 H2B2E_PONAB 90.476 0.984252 1.00794 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009495.1.90 Q8BHN1 TXLNG_MOUSE 79.221 0.974359 0.148855 Txlng - Gamma-taxilin - Mus musculus (Mouse) - Txlng gene May be involved in intracellular vesicle traffic (By similarity). Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. Indicus|evm.model.CM009495.1.92 Q6ZR37 PKHG7_HUMAN 88.391 0.548621 1.81794 PLEKHG7 - Pleckstrin homology domain-containing family G member 7 - Homo sapiens (Human) - PLEKHG7 gene Rho protein signal transduction Indicus|evm.model.CM009495.1.93 Q15075 EEA1_HUMAN 91.637 0.998583 1 EEA1 - Early endosome antigen 1 - Homo sapiens (Human) - EEA1 gene Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. Indicus|evm.model.CM009495.1.94 A0A024RBG1 NUD4B_HUMAN 97.238 0.989011 1.00552 NUDT4B - Diphosphoinositol polyphosphate phosphohydrolase NUDT4B - Homo sapiens (Human) - NUDT4B gene Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Indicus|evm.model.CM009495.1.95 Q5R7J6 UBE2N_PONAB 100.000 0.986928 1.00658 UBE2N - Ubiquitin-conjugating enzyme E2 N - Pongo abelii (Sumatran orangutan) - UBE2N gene The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. Indicus|evm.model.CM009495.1.97 P82927 RM42_BOVIN 100.000 0.986014 1.00704 MRPL42 - 39S ribosomal protein L42, mitochondrial precursor - Bos taurus (Bovine) - MRPL42 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Indicus|evm.model.CM009495.1.98 Q861R0 SOCS2_BOVIN 99.495 0.629393 1.58081 SOCS2 - Suppressor of cytokine signaling 2 - Bos taurus (Bovine) - SOCS2 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Indicus|evm.model.CM009495.1.99 O88843 CRADD_MOUSE 93.827 0.610687 0.658291 Cradd - Death domain-containing protein CRADD - Mus musculus (Mouse) - Cradd gene Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. Indicus|evm.model.CM009495.1.100 Q5R6X7 CBX3_PONAB 66.474 0.984127 0.688525 CBX3 - Chromobox protein homolog 3 - Pongo abelii (Sumatran orangutan) - CBX3 gene Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). Indicus|evm.model.CM009495.1.101 Q5R6I4 CRADD_PONAB 86.869 0.924528 0.532663 CRADD - Death domain-containing protein CRADD - Pongo abelii (Sumatran orangutan) - CRADD gene Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. Indicus|evm.model.CM009495.1.102 O60486 PLXC1_HUMAN 88.595 0.761838 0.915816 PLXNC1 - Plexin-C1 precursor - Homo sapiens (Human) - PLXNC1 gene Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). Indicus|evm.model.CM009495.1.103 Q9Y592 CEP83_HUMAN 87.161 0.997147 1 CEP83 - Centrosomal protein of 83 kDa - Homo sapiens (Human) - CEP83 gene Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly. Indicus|evm.model.CM009495.1.105 Q9ULS5 TMCC3_HUMAN 93.082 0.995816 1.0021 TMCC3 - Transmembrane and coiled-coil domain protein 3 - Homo sapiens (Human) - TMCC3 gene endomembrane system, endoplasmic reticulum, 14-3-3 protein binding, identical protein binding Indicus|evm.model.CM009495.1.106 O97725 NDUAC_BOVIN 80.000 0.983051 0.813793 NDUFA12 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 - Bos taurus (Bovine) - NDUFA12 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009495.1.107 A0JNE3 NR2C1_BOVIN 99.671 0.996716 1.00164 NR2C1 - Nuclear receptor subfamily 2 group C member 1 - Bos taurus (Bovine) - NR2C1 gene Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity). Indicus|evm.model.CM009495.1.108 Q6ZV73 FGD6_HUMAN 83.554 0.998606 1.0035 FGD6 - FYVE, RhoGEF and PH domain-containing protein 6 - Homo sapiens (Human) - FGD6 gene May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). Indicus|evm.model.CM009495.1.109 Q9HBM0 VEZA_HUMAN 89.193 0.974457 1.00513 VEZT - Vezatin - Homo sapiens (Human) - VEZT gene Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. Indicus|evm.model.CM009495.1.111 Q3ZC89 MAP2_BOVIN 99.581 0.995816 1.0021 METAP2 - Methionine aminopeptidase 2 - Bos taurus (Bovine) - METAP2 gene Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Indicus|evm.model.CM009495.1.112 D2HBJ8 UBP44_AILME 92.275 0.997183 0.998594 USP44 - Ubiquitin carboxyl-terminal hydrolase 44 - Ailuropoda melanoleuca (Giant panda) - USP44 gene Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination (By similarity). Indicus|evm.model.CM009495.1.113 Q29407 MEA1_BOVIN 85.976 0.986577 0.856322 MEA1 - Male-enhanced antigen 1 - Bos taurus (Bovine) - MEA1 gene May play an important role in spermatogenesis and/or testis development. Indicus|evm.model.CM009495.1.114 Q9UKY7 CDV3_HUMAN 88.660 0.931373 0.395349 CDV3 - Protein CDV3 homolog - Homo sapiens (Human) - CDV3 gene cytoplasm, cytosol, plasma membrane Indicus|evm.model.CM009495.1.116 P80195 GLCM1_BOVIN 100.000 0.987013 1.00654 GLYCAM1 - Glycosylation-dependent cell adhesion molecule 1 precursor - Bos taurus (Bovine) - GLYCAM1 gene identical protein binding Indicus|evm.model.CM009495.1.117 P19103 PPR1A_RAT 82.677 0.875 0.842105 Ppp1r1a - Protein phosphatase 1 regulatory subunit 1A - Rattus norvegicus (Rat) - Ppp1r1a gene Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. Indicus|evm.model.CM009495.1.118 Q01061 PDE1B_BOVIN 99.252 0.996269 1.00375 PDE1B - Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B - Bos taurus (Bovine) - PDE1B gene Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate (By similarity). Indicus|evm.model.CM009495.1.119 P55160 NCKPL_HUMAN 94.765 0.99207 1.0071 NCKAP1L - Nck-associated protein 1-like - Homo sapiens (Human) - NCKAP1L gene Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells (PubMed:32647003). Required for efficient T-lymphocyte and neutrophil migration (PubMed:32647003). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (PubMed:32647003). Indicus|evm.model.CM009495.1.120 Q3SZU0 GTSF1_BOVIN 100.000 0.761468 1.30539 GTSF1 - Gametocyte-specific factor 1 - Bos taurus (Bovine) - GTSF1 gene Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells. Indicus|evm.model.CM009495.1.121 P08648 ITA5_HUMAN 92.512 0.998106 1.00667 ITGA5 - Integrin alpha-5 precursor - Homo sapiens (Human) - ITGA5 gene Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). Indicus|evm.model.CM009495.1.122 Q96PM9 Z385A_HUMAN 97.409 0.994832 1.00259 ZNF385A - Zinc finger protein 385A - Homo sapiens (Human) - ZNF385A gene RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. Indicus|evm.model.CM009495.1.123 Q2KI97 GPR84_BOVIN 100.000 0.994962 1.00253 GPR84 - G-protein coupled receptor 84 - Bos taurus (Bovine) - GPR84 gene Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity). Indicus|evm.model.CM009495.1.124 P35604 COPZ1_BOVIN 100.000 0.988764 1.00565 COPZ1 - Coatomer subunit zeta-1 - Bos taurus (Bovine) - COPZ1 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). Indicus|evm.model.CM009495.1.125 Q3SZA5 SPSY_BOVIN 98.276 0.991416 0.638356 SMS - Spermine synthase - Bos taurus (Bovine) - SMS gene Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). Indicus|evm.model.CM009495.1.126 Q5EAD3 NFE2_BOVIN 100.000 0.715931 1.39305 NFE2 - Transcription factor NF-E2 45 kDa subunit - Bos taurus (Bovine) - NFE2 gene Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity). Indicus|evm.model.CM009495.1.127 P09651 ROA1_HUMAN 99.732 0.994652 1.00538 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Homo sapiens (Human) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). Indicus|evm.model.CM009495.1.128 P45973 CBX5_HUMAN 100.000 0.989583 1.00524 CBX5 - Chromobox protein homolog 5 - Homo sapiens (Human) - CBX5 gene Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Indicus|evm.model.CM009495.1.129 Q59I47 SMUG1_BOVIN 100.000 0.992674 1.00368 SMUG1 - Single-strand selective monofunctional uracil DNA glycosylase - Bos taurus (Bovine) - SMUG1 gene Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. Indicus|evm.model.CM009495.1.130 P09017 HXC4_HUMAN 99.621 0.992453 1.00379 HOXC4 - Homeobox protein Hox-C4 - Homo sapiens (Human) - HOXC4 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009495.1.131 P32043 HXC5_MOUSE 99.550 0.991031 1.0045 Hoxc5 - Homeobox protein Hox-C5 - Mus musculus (Mouse) - Hoxc5 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009495.1.132 P49925 HXC6_SHEEP 100.000 0.644068 1.54248 HOXC6 - Homeobox protein Hox-C6 - Ovis aries (Sheep) - HOXC6 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009495.1.133 P09633 HXC9_MOUSE 99.578 0.506438 1.79231 Hoxc9 - Homeobox protein Hox-C9 - Mus musculus (Mouse) - Hoxc9 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009495.1.134 Q9NYD6 HXC10_HUMAN 97.388 0.491713 1.58772 HOXC10 - Homeobox protein Hox-C10 - Homo sapiens (Human) - HOXC10 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009495.1.135 P31275 HXC12_HUMAN 96.479 0.992908 1 HOXC12 - Homeobox protein Hox-C12 - Homo sapiens (Human) - HOXC12 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009495.1.136 P31276 HXC13_HUMAN 98.905 0.992727 0.833333 HOXC13 - Homeobox protein Hox-C13 - Homo sapiens (Human) - HOXC13 gene Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity). Indicus|evm.model.CM009495.1.137 Q2KJ21 CACO1_BOVIN 97.085 0.988456 1.01912 CALCOCO1 - Calcium-binding and coiled-coil domain-containing protein 1 - Bos taurus (Bovine) - CALCOCO1 gene Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (By similarity). Indicus|evm.model.CM009495.1.138 P84100 RL19_RAT 86.885 0.967742 0.316327 Rpl19 - 60S ribosomal protein L19 - Rattus norvegicus (Rat) - Rpl19 gene cytosolic large ribosomal subunit, polysomal ribosome, synapse, 5.8S rRNA binding, large ribosomal subunit rRNA binding, RNA binding, structural constituent of ribosome, cytoplasmic translation, liver regeneration Indicus|evm.model.CM009495.1.139 P07926 AT5G2_BOVIN 100.000 0.986111 1.00699 ATP5MC2 - ATP synthase F(0) complex subunit C2, mitochondrial precursor - Bos taurus (Bovine) - ATP5MC2 gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. Indicus|evm.model.CM009495.1.140 P17544 ATF7_HUMAN 98.344 0.995868 1.00207 ATF7 - Cyclic AMP-dependent transcription factor ATF-7 - Homo sapiens (Human) - ATF7 gene Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (PubMed:29490055). In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (By similarity). Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (By similarity). In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (PubMed:29490055). Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (By similarity). Indicus|evm.model.CM009495.1.141 Q0IIG6 TRBP2_BOVIN 100.000 0.755694 1.31967 TARBP2 - RISC-loading complex subunit TARBP2 - Bos taurus (Bovine) - TARBP2 gene Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Indicus|evm.model.CM009495.1.142 Q60700 M3K12_MOUSE 95.969 0.997763 1.00676 Map3k12 - Mitogen-activated protein kinase kinase kinase 12 - Mus musculus (Mouse) - Map3k12 gene Protein kinase which is part of a non-canonical MAPK signaling pathway (PubMed:7983011, PubMed:8663324, PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. Indicus|evm.model.CM009495.1.143 Q61990 PCBP2_MOUSE 100.000 0.99449 1.00276 Pcbp2 - Poly(rC)-binding protein 2 - Mus musculus (Mouse) - Pcbp2 gene Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation (By similarity). Indicus|evm.model.CM009495.1.144 Q9NZ81 PRR13_HUMAN 81.132 0.739437 0.959459 PRR13 - Proline-rich protein 13 - Homo sapiens (Human) - PRR13 gene Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis. Indicus|evm.model.CM009495.1.145 Q28616 AMHR2_RABIT 85.385 0.950459 0.957821 AMHR2 - Anti-Muellerian hormone type-2 receptor precursor - Oryctolagus cuniculus (Rabbit) - AMHR2 gene On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Indicus|evm.model.CM009495.1.146 P08047 SP1_HUMAN 96.662 0.997436 0.993631 SP1 - Transcription factor Sp1 - Homo sapiens (Human) - SP1 gene Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247, PubMed:21046154). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). Indicus|evm.model.CM009495.1.147 Q8TDD2 SP7_HUMAN 96.984 0.879346 1.13457 SP7 - Transcription factor Sp7 - Homo sapiens (Human) - SP7 gene Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). Indicus|evm.model.CM009495.1.148 Q9NRG9 AAAS_HUMAN 95.971 0.994526 1.00366 AAAS - Aladin - Homo sapiens (Human) - AAAS gene Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606). Indicus|evm.model.CM009495.1.149 Q58DG1 MYG1_BOVIN 100.000 0.994764 1.00262 MYG1 - MYG1 exonuclease precursor - Bos taurus (Bovine) - MYG1 gene 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins. Indicus|evm.model.CM009495.1.150 Q8HYI9 PFD5_BOVIN 100.000 0.987097 1.00649 PFDN5 - Prefoldin subunit 5 - Bos taurus (Bovine) - PFDN5 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity). Indicus|evm.model.CM009495.1.151 Q14674 ESPL1_HUMAN 83.608 0.994787 0.995283 ESPL1 - Separin - Homo sapiens (Human) - ESPL1 gene Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. Indicus|evm.model.CM009495.1.152 Q0VC03 MFSD5_BOVIN 100.000 0.995565 1.00222 MFSD5 - Molybdate-anion transporter - Bos taurus (Bovine) - MFSD5 gene Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. Indicus|evm.model.CM009495.1.153 P13631 RARG_HUMAN 98.886 0.976035 1.01101 RARG - Retinoic acid receptor gamma - Homo sapiens (Human) - RARG gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Indicus|evm.model.CM009495.1.154 P26010 ITB7_HUMAN 87.250 0.997503 1.00376 ITGB7 - Integrin beta-7 precursor - Homo sapiens (Human) - ITGB7 gene Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin. Indicus|evm.model.CM009495.1.155 Q8NDX6 ZN740_HUMAN 99.482 0.989691 1.00518 ZNF740 - Zinc finger protein 740 - Homo sapiens (Human) - ZNF740 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009495.1.157 Q9Y600 CSAD_HUMAN 90.669 0.995951 1.00203 CSAD - Cysteine sulfinic acid decarboxylase - Homo sapiens (Human) - CSAD gene Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate. Indicus|evm.model.CM009495.1.158 O77759 SOAT2_CHLAE 86.920 0.684515 1.31369 SOAT2 - Sterol O-acyltransferase 2 - Chlorocebus aethiops (Green monkey) - SOAT2 gene Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. Indicus|evm.model.CM009495.1.159 Q8NCJ5 SPRY3_HUMAN 95.928 0.995327 0.968326 SPRYD3 - SPRY domain-containing protein 3 - Homo sapiens (Human) - SPRYD3 gene cytoplasm, cell surface receptor signaling pathway, cytoskeleton organization Indicus|evm.model.CM009495.1.160 Q63HR2 TNS2_HUMAN 92.974 0.998582 1.00071 TNS2 - Tensin-2 - Homo sapiens (Human) - TNS2 gene Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856). Indicus|evm.model.CM009495.1.161 P23588 IF4B_HUMAN 95.581 0.996727 1 EIF4B - Eukaryotic translation initiation factor 4B - Homo sapiens (Human) - EIF4B gene Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. Indicus|evm.model.CM009495.1.162 P05783 K1C18_HUMAN 88.605 0.995349 1 KRT18 - Keratin, type I cytoskeletal 18 - Homo sapiens (Human) - KRT18 gene Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. Indicus|evm.model.CM009495.1.163 P05786 K2C8_BOVIN 93.515 0.995556 0.941423 KRT8 - Keratin, type II cytoskeletal 8 - Bos taurus (Bovine) - KRT8 gene Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Indicus|evm.model.CM009495.1.164 A6QNX5 K2C78_BOVIN 99.811 0.996219 1.00189 KRT78 - Keratin, type II cytoskeletal 78 - Bos taurus (Bovine) - KRT78 gene Indicus|evm.model.CM009495.1.165 Q148H7 K2C79_BOVIN 99.252 0.996269 1.00187 KRT79 - Keratin, type II cytoskeletal 79 - Bos taurus (Bovine) - KRT79 gene Indicus|evm.model.CM009495.1.166 P19013 K2C4_HUMAN 84.760 0.869091 1.05769 KRT4 - Keratin, type II cytoskeletal 4 - Homo sapiens (Human) - KRT4 gene cell surface, cytosol, intermediate filament, intermediate filament cytoskeleton, keratin filament, nucleus, cornification, cytoskeleton organization, epithelial cell differentiation, keratinization Indicus|evm.model.CM009495.1.167 P12035 K2C3_HUMAN 91.643 0.570016 0.966561 KRT3 - Keratin, type II cytoskeletal 3 - Homo sapiens (Human) - KRT3 gene cytosol, extracellular exosome, intermediate filament, keratin filament, cornification, epithelial cell differentiation, intermediate filament cytoskeleton organization, keratinization Indicus|evm.model.CM009495.1.168 Q01546 K22O_HUMAN 82.873 0.603679 0.937304 KRT76 - Keratin, type II cytoskeletal 2 oral - Homo sapiens (Human) - KRT76 gene Probably contributes to terminal cornification. Indicus|evm.model.CM009495.1.169 Q7Z794 K2C1B_HUMAN 82.920 0.348748 1.79585 KRT77 - Keratin, type II cytoskeletal 1b - Homo sapiens (Human) - KRT77 gene cytoskeleton, cytosol, extracellular exosome, cornification, keratinization Indicus|evm.model.CM009495.1.170 A5A6M6 K2C1_PANTR 83.747 0.726524 0.952904 KRT1 - Keratin, type II cytoskeletal 1 - Pan troglodytes (Chimpanzee) - KRT1 gene May regulate the activity of kinases such as PKC and SRC via binding to integrin beta 1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity). Indicus|evm.model.CM009495.1.171 Q6EIZ1 K22E_CANLF 75.477 0.590323 0.979463 KRT2 - Keratin, type II cytoskeletal 2 epidermal - Canis lupus familiaris (Dog) - KRT2 gene Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). Indicus|evm.model.CM009495.1.172 A7YWK3 K2C73_BOVIN 99.815 0.996303 1.00185 KRT73 - Keratin, type II cytoskeletal 73 - Bos taurus (Bovine) - KRT73 gene Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). Indicus|evm.model.CM009495.1.173 Q148H8 K2C72_BOVIN 99.237 0.99619 1.00191 KRT72 - Keratin, type II cytoskeletal 72 - Bos taurus (Bovine) - KRT72 gene Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). Indicus|evm.model.CM009495.1.174 A3KN27 K2C74_BOVIN 96.545 0.996276 0.976364 KRT74 - Keratin, type II cytoskeletal 74 - Bos taurus (Bovine) - KRT74 gene Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). Indicus|evm.model.CM009495.1.175 Q148H5 K2C71_BOVIN 100.000 0.996198 1.0019 KRT71 - Keratin, type II cytoskeletal 71 - Bos taurus (Bovine) - KRT71 gene Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. Indicus|evm.model.CM009495.1.176 Q5XQN5 K2C5_BOVIN 99.334 0.996656 0.995008 KRT5 - Keratin, type II cytoskeletal 5 - Bos taurus (Bovine) - KRT5 gene epithelial cell differentiation, negative regulation of epithelial cell proliferation Indicus|evm.model.CM009495.1.177 P02538 K2C6A_HUMAN 87.149 0.968811 0.909574 KRT6A - Keratin, type II cytoskeletal 6A - Homo sapiens (Human) - KRT6A gene Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Indicus|evm.model.CM009495.1.178 P02538 K2C6A_HUMAN 86.774 0.870629 1.01418 KRT6A - Keratin, type II cytoskeletal 6A - Homo sapiens (Human) - KRT6A gene Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Indicus|evm.model.CM009495.1.179 P02538 K2C6A_HUMAN 87.174 0.625628 1.41135 KRT6A - Keratin, type II cytoskeletal 6A - Homo sapiens (Human) - KRT6A gene Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Indicus|evm.model.CM009495.1.180 Q08D91 K2C75_BOVIN 99.079 0.996324 1.00184 KRT75 - Keratin, type II cytoskeletal 75 - Bos taurus (Bovine) - KRT75 gene Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity). Indicus|evm.model.CM009495.1.181 Q6P6Q2 K2C5_RAT 78.804 0.68609 0.923611 Krt5 - Keratin, type II cytoskeletal 5 - Rattus norvegicus (Rat) - Krt5 gene cytoplasm, intermediate filament, keratin filament, scaffold protein binding Indicus|evm.model.CM009495.1.182 Q9NSB4 KRT82_HUMAN 83.333 0.432408 2.17739 KRT82 - Keratin, type II cuticular Hb2 - Homo sapiens (Human) - KRT82 gene cytosol, keratin filament, structural constituent of skin epidermis, cornification, keratinization Indicus|evm.model.CM009495.1.183 P25691 K2M3_SHEEP 96.838 0.994094 1.01195 Keratin, type II microfibrillar, component 5 - Ovis aries (Sheep) Indicus|evm.model.CM009495.1.184 P25691 K2M3_SHEEP 74.220 0.948104 0.998008 Keratin, type II microfibrillar, component 5 - Ovis aries (Sheep) Indicus|evm.model.CM009495.1.185 A4FUZ0 KRT83_BOVIN 97.908 0.937132 1.03245 KRT83 - Keratin, type II cuticular Hb3 - Bos taurus (Bovine) - KRT83 gene Indicus|evm.model.CM009495.1.186 Q148H4 KRT81_BOVIN 93.595 0.98768 0.974 KRT81 - Keratin, type II cuticular Hb1 - Bos taurus (Bovine) - KRT81 gene Indicus|evm.model.CM009495.1.187 Q148H4 KRT81_BOVIN 99.800 0.996008 1.002 KRT81 - Keratin, type II cuticular Hb1 - Bos taurus (Bovine) - KRT81 gene Indicus|evm.model.CM009495.1.188 Q148H4 KRT81_BOVIN 82.989 0.654021 1.318 KRT81 - Keratin, type II cuticular Hb1 - Bos taurus (Bovine) - KRT81 gene Indicus|evm.model.CM009495.1.189 Q148H4 KRT81_BOVIN 88.985 0.907662 1.018 KRT81 - Keratin, type II cuticular Hb1 - Bos taurus (Bovine) - KRT81 gene Indicus|evm.model.CM009495.1.190 Q29S21 K2C7_BOVIN 99.356 0.995717 1.00215 KRT7 - Keratin, type II cytoskeletal 7 - Bos taurus (Bovine) - KRT7 gene Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Indicus|evm.model.CM009495.1.191 A0JND2 K2C80_BOVIN 100.000 0.907285 1.07346 KRT80 - Keratin, type II cytoskeletal 80 - Bos taurus (Bovine) - KRT80 gene Indicus|evm.model.CM009495.1.192 A0A2R8YCJ5 SIM41_HUMAN 81.111 0.967391 0.989247 SMIM41 - Small integral membrane protein 41 - Homo sapiens (Human) - SMIM41 gene Indicus|evm.model.CM009495.1.193 Q2HJE0 ATGA1_BOVIN 100.000 0.990868 1.00459 ATG101 - Autophagy-related protein 101 - Bos taurus (Bovine) - ATG101 gene Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. Indicus|evm.model.CM009495.1.194 Q0V8F0 NR4A1_BOVIN 100.000 0.940157 1.06187 NR4A1 - Nuclear receptor subfamily 4 group A member 1 - Bos taurus (Bovine) - NR4A1 gene Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (By similarity). Indicus|evm.model.CM009495.1.195 Q7Z6J2 GRASP_HUMAN 89.615 0.844884 0.767089 TAMALIN - Protein TAMALIN - Homo sapiens (Human) - TAMALIN gene Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. Indicus|evm.model.CM009495.1.196 P36896 ACV1B_HUMAN 99.558 0.995595 0.89901 ACVR1B - Activin receptor type-1B precursor - Homo sapiens (Human) - ACVR1B gene Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. Indicus|evm.model.CM009495.1.197 P37023 ACVL1_HUMAN 91.054 0.994048 1.00199 ACVRL1 - Serine/threonine-protein kinase receptor R3 precursor - Homo sapiens (Human) - ACVRL1 gene Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. Indicus|evm.model.CM009495.1.198 Q7Z3H0 PANKY_HUMAN 75.510 0.967337 0.880531 ANKRD33 - Photoreceptor ankyrin repeat protein - Homo sapiens (Human) - ANKRD33 gene Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation. Indicus|evm.model.CM009495.1.199 A6NMB9 FIGL2_HUMAN 91.047 0.996956 1.00613 FIGNL2 - Fidgetin-like protein 2 - Homo sapiens (Human) - FIGNL2 gene nucleus, ATPase activity, microtubule-severing ATPase activity, cytoplasmic microtubule organization Indicus|evm.model.CM009495.1.200 P0DPE3 TMDD1_HUMAN 68.771 0.986711 0.949527 TMDD1 - Transmembrane and death domain protein 1 precursor - Homo sapiens (Human) - TMDD1 gene Indicus|evm.model.CM009495.1.201 Q9UQD0 SCN8A_HUMAN 97.960 0.999005 1.01566 SCN8A - Sodium channel protein type 8 subunit alpha - Homo sapiens (Human) - SCN8A gene Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Indicus|evm.model.CM009495.1.202 Q2Y0W8 S4A8_HUMAN 97.987 0.99817 1 SLC4A8 - Electroneutral sodium bicarbonate exchanger 1 - Homo sapiens (Human) - SLC4A8 gene Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. Indicus|evm.model.CM009495.1.204 Q5EA41 GALT6_BOVIN 99.839 0.99679 1.00161 GALNT6 - Polypeptide N-acetylgalactosaminyltransferase 6 - Bos taurus (Bovine) - GALNT6 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides (By similarity). Indicus|evm.model.CM009495.1.205 Q28153 CELA1_BOVIN 100.000 0.992509 1.00376 CELA1 - Chymotrypsin-like elastase family member 1 precursor - Bos taurus (Bovine) - CELA1 gene Acts upon elastin. Indicus|evm.model.CM009495.1.206 Q5ZKL7 BIN2_CHICK 79.323 0.355705 1.56513 BIN2 - Bridging integrator 2 - Gallus gallus (Chicken) - BIN2 gene plasma membrane, podosome, phospholipid binding, phagocytosis, engulfment, plasma membrane tubulation, podosome assembly Indicus|evm.model.CM009495.1.207 Q5R526 DAZP2_PONAB 100.000 0.988166 1.00595 DAZAP2 - DAZ-associated protein 2 - Pongo abelii (Sumatran orangutan) - DAZAP2 gene Indicus|evm.model.CM009495.1.208 Q14863 PO6F1_HUMAN 98.671 0.490196 2.03322 POU6F1 - POU domain, class 6, transcription factor 1 - Homo sapiens (Human) - POU6F1 gene Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3'). Indicus|evm.model.CM009495.1.209 Q12800 TFCP2_HUMAN 99.366 0.729102 1.28685 TFCP2 - Alpha-globin transcription factor CP2 - Homo sapiens (Human) - TFCP2 gene Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. Indicus|evm.model.CM009495.1.210 A3KN46 LTMD1_BOVIN 99.722 0.99446 1.00278 LETMD1 - LETM1 domain-containing protein 1 - Bos taurus (Bovine) - LETMD1 gene May function as a negative regulator of the p53/TP53. Indicus|evm.model.CM009495.1.211 Q9H175 CSRN2_HUMAN 92.138 0.962085 0.777164 CSRNP2 - Cysteine/serine-rich nuclear protein 2 - Homo sapiens (Human) - CSRNP2 gene Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis. Indicus|evm.model.CM009495.1.212 P49281 NRAM2_HUMAN 93.322 0.859304 1.16373 SLC11A2 - Natural resistance-associated macrophage protein 2 - Homo sapiens (Human) - SLC11A2 gene Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. Indicus|evm.model.CM009495.1.213 Q9H8H3 MET7A_HUMAN 63.253 0.957447 0.577869 METTL7A - Methyltransferase-like protein 7A precursor - Homo sapiens (Human) - METTL7A gene Probable methyltransferase. Indicus|evm.model.CM009495.1.214 P49282 NRAM2_MOUSE 83.582 0.923744 1.01585 Slc11a2 - Natural resistance-associated macrophage protein 2 - Mus musculus (Mouse) - Slc11a2 gene May serve to import iron into the mitochondria (By similarity). Important in metal transport, in particular iron. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. Indicus|evm.model.CM009495.1.215 Q9H8H3 MET7A_HUMAN 81.657 0.954545 0.721311 METTL7A - Methyltransferase-like protein 7A precursor - Homo sapiens (Human) - METTL7A gene Probable methyltransferase. Indicus|evm.model.CM009495.1.216 P49282 NRAM2_MOUSE 86.372 0.855784 1.11092 Slc11a2 - Natural resistance-associated macrophage protein 2 - Mus musculus (Mouse) - Slc11a2 gene May serve to import iron into the mitochondria (By similarity). Important in metal transport, in particular iron. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. Indicus|evm.model.CM009495.1.217 A8MV81 HIG1C_HUMAN 91.667 0.734513 1.16495 HIGD1C - HIG1 domain family member 1C - Homo sapiens (Human) - HIGD1C gene mitochondrion, mitochondrial respirasome assembly Indicus|evm.model.CM009495.1.219 Q9H8H3 MET7A_HUMAN 86.475 0.991837 1.0041 METTL7A - Methyltransferase-like protein 7A precursor - Homo sapiens (Human) - METTL7A gene Probable methyltransferase. Indicus|evm.model.CM009495.1.220 Q2TBH8 ZWINT_BOVIN 99.301 0.993031 1.0035 ZWINT - ZW10 interactor - Bos taurus (Bovine) - ZWINT gene Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity). Indicus|evm.model.CM009495.1.221 Q86WS5 TMPSC_HUMAN 74.809 0.872483 0.428161 TMPRSS12 - Transmembrane protease serine 12 precursor - Homo sapiens (Human) - TMPRSS12 gene Indicus|evm.model.CM009495.1.222 P24049 RL17_RAT 82.424 0.83871 1.01087 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009495.1.223 Q08DA8 ATF1_BOVIN 100.000 0.99262 1.0037 ATF1 - Cyclic AMP-dependent transcription factor ATF-1 - Bos taurus (Bovine) - ATF1 gene This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity). Indicus|evm.model.CM009495.1.224 Q9P265 DIP2B_HUMAN 98.794 0.998731 1 DIP2B - Disco-interacting protein 2 homolog B - Homo sapiens (Human) - DIP2B gene Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. Indicus|evm.model.CM009495.1.225 Q71RC2 LARP4_HUMAN 89.381 0.777778 0.198895 LARP4 - La-related protein 4 - Homo sapiens (Human) - LARP4 gene RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). Indicus|evm.model.CM009495.1.226 Q71RC2 LARP4_HUMAN 87.159 0.993579 0.860497 LARP4 - La-related protein 4 - Homo sapiens (Human) - LARP4 gene RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). Indicus|evm.model.CM009495.1.227 Q9D9R9 F186A_MOUSE 58.696 0.0377437 1.34693 FAM186A - Protein FAM186A - Mus musculus (Mouse) - FAM186A gene Indicus|evm.model.CM009495.1.228 B0KYV5 LIMA1_PIG 85.220 0.96401 1.0291 LIMA1 - LIM domain and actin-binding protein 1 - Sus scrofa (Pig) - LIMA1 gene Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). Indicus|evm.model.CM009495.1.229 Q8N5B7 CERS5_HUMAN 90.306 0.994911 1.00255 CERS5 - Ceramide synthase 5 - Homo sapiens (Human) - CERS5 gene Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). Indicus|evm.model.CM009495.1.230 Q1RMH3 COX14_BOVIN 100.000 0.54902 1.78947 COX14 - Cytochrome c oxidase assembly protein COX14 - Bos taurus (Bovine) - COX14 gene Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. Indicus|evm.model.CM009495.1.231 Q5EA88 GPDA_BOVIN 100.000 0.763158 1.30659 GPD1 - Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic - Bos taurus (Bovine) - GPD1 gene Has glycerol-3-phosphate dehydrogenase activity. Indicus|evm.model.CM009495.1.233 Q96GM5 SMRD1_HUMAN 99.612 0.996124 1.00194 SMARCD1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 - Homo sapiens (Human) - SMARCD1 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342). Indicus|evm.model.CM009495.1.234 P78348 ASIC1_HUMAN 79.767 0.891071 1.06061 ASIC1 - Acid-sensing ion channel 1 - Homo sapiens (Human) - ASIC1 gene Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. Indicus|evm.model.CM009495.1.235 P78348 ASIC1_HUMAN 99.462 0.872642 0.401515 ASIC1 - Acid-sensing ion channel 1 - Homo sapiens (Human) - ASIC1 gene Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. Indicus|evm.model.CM009495.1.236 Q9H0H5 RGAP1_HUMAN 95.411 0.99684 1.00158 RACGAP1 - Rac GTPase-activating protein 1 - Homo sapiens (Human) - RACGAP1 gene Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. Indicus|evm.model.CM009495.1.237 Q9WTY0 AQP6_RAT 80.364 0.971631 1.02174 Aqp6 - Aquaporin-6 - Rattus norvegicus (Rat) - Aqp6 gene Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. Indicus|evm.model.CM009495.1.238 Q866S3 AQP5_SHEEP 96.981 0.676923 1.4717 AQP5 - Aquaporin-5 - Ovis aries (Sheep) - AQP5 gene Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). Indicus|evm.model.CM009495.1.239 P79099 AQP2_BOVIN 100.000 0.992647 1.00369 AQP2 - Aquaporin-2 - Bos taurus (Bovine) - AQP2 gene Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Indicus|evm.model.CM009495.1.240 Q1LZ71 LFG2_BOVIN 100.000 0.993691 1.00316 FAIM2 - Protein lifeguard 2 - Bos taurus (Bovine) - FAIM2 gene Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity). Indicus|evm.model.CM009495.1.241 Q29S19 BN3D2_BOVIN 97.468 0.0518617 5.15068 BCDIN3D - RNA 5'-monophosphate methyltransferase - Bos taurus (Bovine) - BCDIN3D gene O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145. Indicus|evm.model.CM009495.1.242 Q0V882 BI1_BOVIN 100.000 0.991561 1.00424 TMBIM6 - Bax inhibitor 1 - Bos taurus (Bovine) - TMBIM6 gene Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation. Indicus|evm.model.CM009495.1.243 Q8IVF7 FMNL3_HUMAN 96.943 0.985409 1 FMNL3 - Formin-like protein 3 - Homo sapiens (Human) - FMNL3 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. Indicus|evm.model.CM009495.1.244 Q6NWY9 PR40B_HUMAN 91.441 0.974549 1.08266 PRPF40B - Pre-mRNA-processing factor 40 homolog B - Homo sapiens (Human) - PRPF40B gene May be involved in pre-mRNA splicing. Indicus|evm.model.CM009495.1.245 Q8IYM0 F186B_HUMAN 68.257 0.932079 1.07167 FAM186B - Protein FAM186B - Homo sapiens (Human) - FAM186B gene protein-containing complex Indicus|evm.model.CM009495.1.246 Q96EZ8 MCRS1_HUMAN 99.351 0.99568 1.00216 MCRS1 - Microspherule protein 1 - Homo sapiens (Human) - MCRS1 gene Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Indicus|evm.model.CM009495.1.247 Q9ULD8 KCNH3_HUMAN 94.373 0.99814 0.992613 KCNH3 - Potassium voltage-gated channel subfamily H member 3 - Homo sapiens (Human) - KCNH3 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly. Indicus|evm.model.CM009495.1.248 Q86XZ4 SPAS2_HUMAN 88.462 0.996344 1.00367 SPATS2 - Spermatogenesis-associated serine-rich protein 2 - Homo sapiens (Human) - SPATS2 gene cytoplasm, cytosol, RNA binding Indicus|evm.model.CM009495.1.250 Q17QW0 DJC22_BOVIN 100.000 0.994253 1.00288 DNAJC22 - DnaJ homolog subfamily C member 22 - Bos taurus (Bovine) - DNAJC22 gene May function as a co-chaperone. Indicus|evm.model.CM009495.1.251 Q4ZJM9 C1QL4_MOUSE 99.153 0.806897 0.609244 C1ql4 - Complement C1q-like protein 4 precursor - Mus musculus (Mouse) - C1ql4 gene May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. May inhibit adipocyte differentiation at an early stage of the process. Indicus|evm.model.CM009495.1.252 Q12815 TROAP_HUMAN 68.123 0.995828 0.924165 TROAP - Tastin - Homo sapiens (Human) - TROAP gene Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Indicus|evm.model.CM009495.1.253 P49247 RPIA_HUMAN 74.000 0.826087 0.369775 RPIA - Ribose-5-phosphate isomerase - Homo sapiens (Human) - RPIA gene cytosol, intracellular membrane-bounded organelle, identical protein binding, ribose-5-phosphate isomerase activity, D-ribose metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch Indicus|evm.model.CM009495.1.254 A6QQJ3 PERI_BOVIN 99.787 0.995736 1 PRPH - Peripherin - Bos taurus (Bovine) - PRPH gene Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity). Indicus|evm.model.CM009495.1.255 Q3ZCJ7 TBA1C_BOVIN 98.533 0.621166 1.45212 TUBA1C - Tubulin alpha-1C chain - Bos taurus (Bovine) - TUBA1C gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Indicus|evm.model.CM009495.1.256 Q3ZCJ7 TBA1C_BOVIN 100.000 0.995556 1.00223 TUBA1C - Tubulin alpha-1C chain - Bos taurus (Bovine) - TUBA1C gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Indicus|evm.model.CM009495.1.257 P68370 TBA1A_RAT 100.000 0.995575 1.00222 Tuba1a - Tubulin alpha-1A chain - Rattus norvegicus (Rat) - Tuba1a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009495.1.258 P21741 MK_HUMAN 57.025 0.983333 0.839161 MDK - Midkine precursor - Homo sapiens (Human) - MDK gene Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:18469519, PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:24458438, PubMed:15466886, PubMed:12084985, PubMed:10772929). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:12084985, PubMed:10212223). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:10683378, PubMed:24458438, PubMed:22323540, PubMed:12084985, PubMed:15466886, PubMed:10772929). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity). Indicus|evm.model.CM009495.1.259 Q6P9V9 TBA1B_RAT 100.000 0.995575 1.00222 Tuba1b - Tubulin alpha-1B chain - Rattus norvegicus (Rat) - Tuba1b gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009495.1.260 Q6UX01 LMBRL_HUMAN 96.524 0.995918 1.00204 LMBR1L - Protein LMBR1L - Homo sapiens (Human) - LMBR1L gene Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685). Indicus|evm.model.CM009495.1.261 Q61488 DHH_MOUSE 98.228 0.992443 1.00253 Dhh - Desert hedgehog protein precursor - Mus musculus (Mouse) - Dhh gene Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development. Indicus|evm.model.CM009495.1.262 Q8TAI7 REBL1_HUMAN 95.628 0.98913 1.00546 RHEBL1 - GTPase RhebL1 precursor - Homo sapiens (Human) - RHEBL1 gene Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. Indicus|evm.model.CM009495.1.263 Q6PDK2 KMT2D_MOUSE 89.401 0.280639 0.997316 Kmt2d - Histone-lysine N-methyltransferase 2D - Mus musculus (Mouse) - Kmt2d gene Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. Indicus|evm.model.CM009495.1.264 P58108 AAKG1_BOVIN 100.000 0.993958 1.00303 PRKAG1 - 5'-AMP-activated protein kinase subunit gamma-1 - Bos taurus (Bovine) - PRKAG1 gene AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity). Indicus|evm.model.CM009495.1.265 O94850 DEND_HUMAN 80.175 0.994092 0.95218 DDN - Dendrin - Homo sapiens (Human) - DDN gene Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity). Indicus|evm.model.CM009495.1.266 P04628 WNT1_HUMAN 98.649 0.994609 1.0027 WNT1 - Proto-oncogene Wnt-1 precursor - Homo sapiens (Human) - WNT1 gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646). Indicus|evm.model.CM009495.1.267 O00744 WN10B_HUMAN 94.309 0.784648 1.20566 WNT10B - Protein Wnt-10b precursor - Homo sapiens (Human) - WNT10B gene Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin. Indicus|evm.model.CM009495.1.268 P61207 ARF3_TAKRU 100.000 0.976923 0.718232 arf3 - ADP-ribosylation factor 3 - Takifugu rubripes (Japanese pufferfish) - arf3 gene GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Indicus|evm.model.CM009495.1.269 Q2YDL5 FKB11_BOVIN 99.015 0.990148 1 FKBP11 - Peptidyl-prolyl cis-trans isomerase FKBP11 precursor - Bos taurus (Bovine) - FKBP11 gene PPIases accelerate the folding of proteins during protein synthesis. Indicus|evm.model.CM009495.1.270 Q2TA16 DRC2_BOVIN 100.000 0.995992 1.00201 CCDC65 - Dynein regulatory complex subunit 2 - Bos taurus (Bovine) - CCDC65 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Indicus|evm.model.CM009495.1.271 Q2HJ68 RND1_BOVIN 100.000 0.991416 1.00431 RND1 - Rho-related GTP-binding protein Rho6 precursor - Bos taurus (Bovine) - RND1 gene Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity). Indicus|evm.model.CM009495.1.272 Q9BUQ8 DDX23_HUMAN 99.390 0.997564 1.00122 DDX23 - Probable ATP-dependent RNA helicase DDX23 - Homo sapiens (Human) - DDX23 gene Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Indicus|evm.model.CM009495.1.273 Q9MZL3 CACB3_BOVIN 100.000 0.995876 1.00207 CACNB3 - Voltage-dependent L-type calcium channel subunit beta-3 - Bos taurus (Bovine) - CACNB3 gene Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:10684870). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (PubMed:10684870). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Indicus|evm.model.CM009495.1.274 O43306 ADCY6_HUMAN 95.548 0.998286 0.999144 ADCY6 - Adenylate cyclase type 6 - Homo sapiens (Human) - ADCY6 gene Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity). Indicus|evm.model.CM009495.1.275 A0A1B0GTD5 TEX49_HUMAN 57.252 0.978022 0.694656 TEX49 - Testis-expressed protein 49 - Homo sapiens (Human) - TEX49 gene Indicus|evm.model.CM009495.1.276 Q6T8E9 CCNT1_BOVIN 100.000 0.997253 1.00138 CCNT1 - Cyclin-T1 - Bos taurus (Bovine) - CCNT1 gene Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Indicus|evm.model.CM009495.1.277 Q8BQR4 KANL2_MOUSE 98.190 0.86811 1.04527 Kansl2 - KAT8 regulatory NSL complex subunit 2 - Mus musculus (Mouse) - Kansl2 gene As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. Indicus|evm.model.CM009495.1.278 P49281 NRAM2_HUMAN 60.241 0.66474 0.304577 SLC11A2 - Natural resistance-associated macrophage protein 2 - Homo sapiens (Human) - SLC11A2 gene Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. Indicus|evm.model.CM009495.1.279 P00711 LALBA_BOVIN 100.000 0.986014 1.00704 LALBA - Alpha-lactalbumin precursor - Bos taurus (Bovine) - LALBA gene Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. Indicus|evm.model.CM009495.1.281 Q8NGY5 OR6N1_HUMAN 49.462 0.686567 0.429487 OR6N1 - Olfactory receptor 6N1 - Homo sapiens (Human) - OR6N1 gene Odorant receptor. Indicus|evm.model.CM009495.1.287 Q3SZX7 CL054_BOVIN 100.000 0.984 1.00806 Uncharacterized protein C12orf54 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.289 Q8NH09 OR8S1_HUMAN 59.649 0.565657 0.275766 OR8S1 - Olfactory receptor 8S1 - Homo sapiens (Human) - OR8S1 gene Odorant receptor. Indicus|evm.model.CM009495.1.290 Q96N77 ZN641_HUMAN 95.519 0.995294 0.97032 ZNF641 - Zinc finger protein 641 - Homo sapiens (Human) - ZNF641 gene Transcriptional activator. Activates transcriptional activities of SRE and AP-1. Indicus|evm.model.CM009495.1.291 Q5RKG3 H1FNT_RAT 61.538 0.514286 0.586124 H1-7 - Testis-specific H1 histone - Rattus norvegicus (Rat) - H1-7 gene Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. Indicus|evm.model.CM009495.1.292 Q5RKG3 H1FNT_RAT 61.538 0.514286 0.586124 H1-7 - Testis-specific H1 histone - Rattus norvegicus (Rat) - H1-7 gene Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. Indicus|evm.model.CM009495.1.293 Q58DS6 JMJD6_BOVIN 82.553 0.987234 0.583127 JMJD6 - Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 - Bos taurus (Bovine) - JMJD6 gene Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (By similarity). Indicus|evm.model.CM009495.1.294 Q92889 XPF_HUMAN 62.814 0.989796 0.213974 ERCC4 - DNA repair endonuclease XPF - Homo sapiens (Human) - ERCC4 gene Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. Indicus|evm.model.CM009495.1.295 Q0VC19 CC184_BOVIN 99.487 0.989796 1.00513 CCDC184 - Coiled-coil domain-containing protein 184 - Bos taurus (Bovine) - CCDC184 gene cytoplasm Indicus|evm.model.CM009495.1.296 Q08E43 ASB8_BOVIN 100.000 0.99308 1.00347 ASB8 - Ankyrin repeat and SOCS box protein 8 - Bos taurus (Bovine) - ASB8 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009495.1.297 Q0IIG5 PFKAM_BOVIN 100.000 0.997436 1.00128 PFKM - ATP-dependent 6-phosphofructokinase, muscle type - Bos taurus (Bovine) - PFKM gene Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Indicus|evm.model.CM009495.1.298 Q5RBB1 SENP1_PONAB 91.938 0.865591 1.15349 SENP1 - Sentrin-specific protease 1 - Pongo abelii (Sumatran orangutan) - SENP1 gene Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Deconjugates SUMO2 from MTA1 (By similarity). Deconjugates SUMO1 from METTL3. Desumoylates CCAR2 which decreases its interaction with SIRT1. Deconjugates SUMO1 from GPS2. Indicus|evm.model.CM009495.1.299 P02459 CO2A1_BOVIN 98.790 0.998639 0.988568 COL2A1 - Collagen alpha-1(II) chain precursor - Bos taurus (Bovine) - COL2A1 gene Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Indicus|evm.model.CM009495.1.300 Q3T144 T106C_BOVIN 100.000 0.992 1.00402 TMEM106C - Transmembrane protein 106C - Bos taurus (Bovine) - TMEM106C gene Indicus|evm.model.CM009495.1.301 A4FUH0 RL22L_BOVIN 99.180 0.98374 1.0082 RPL22L1 - 60S ribosomal protein L22-like 1 - Bos taurus (Bovine) - RPL22L1 gene RNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009495.1.302 Q28037 VDR_BOVIN 99.765 0.995305 1 VDR - Vitamin D3 receptor - Bos taurus (Bovine) - VDR gene Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). Indicus|evm.model.CM009495.1.303 Q8WUI4 HDAC7_HUMAN 92.332 0.905263 1.09769 HDAC7 - Histone deacetylase 7 - Homo sapiens (Human) - HDAC7 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Indicus|evm.model.CM009495.1.304 Q6P1K1 HRG1_HUMAN 95.890 0.986395 1.00685 SLC48A1 - Heme transporter HRG1 - Homo sapiens (Human) - SLC48A1 gene Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. Indicus|evm.model.CM009495.1.305 O95398 RPGF3_HUMAN 92.573 0.997849 1.00758 RAPGEF3 - Rap guanine nucleotide exchange factor 3 - Homo sapiens (Human) - RAPGEF3 gene Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. Indicus|evm.model.CM009495.1.306 A6QLQ8 ENDOU_BOVIN 100.000 0.995169 1.00242 ENDOU - Poly(U)-specific endoribonuclease precursor - Bos taurus (Bovine) - ENDOU gene Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini. Indicus|evm.model.CM009495.1.307 Q9H6T3 RPAP3_HUMAN 87.988 0.996997 1.0015 RPAP3 - RNA polymerase II-associated protein 3 - Homo sapiens (Human) - RPAP3 gene Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Indicus|evm.model.CM009495.1.308 A6QL70 PED1B_BOVIN 100.000 0.925081 0.702517 PCED1B - PC-esterase domain-containing protein 1B - Bos taurus (Bovine) - PCED1B gene Indicus|evm.model.CM009495.1.309 Q86SJ2 AMGO2_HUMAN 90.805 0.996169 1 AMIGO2 - Amphoterin-induced protein 2 precursor - Homo sapiens (Human) - AMIGO2 gene Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas. Indicus|evm.model.CM009495.1.310 Q5RE87 S38A4_PONAB 93.784 0.99635 1.00183 SLC38A4 - Sodium-coupled neutral amino acid transporter 4 - Pongo abelii (Sumatran orangutan) - SLC38A4 gene Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by Ser, Gly, Cys, Asn, Thr, Pro and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with highest transport activity between pH 7.5 and 8.5 (By similarity). Indicus|evm.model.CM009495.1.311 Q2VIR3 IF2GL_HUMAN 78.788 0.844828 0.245763 EIF2S3B - Eukaryotic translation initiation factor 2 subunit 3B - Homo sapiens (Human) - EIF2S3B gene As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). Indicus|evm.model.CM009495.1.313 A2VE31 S38A2_BOVIN 100.000 0.996055 1.00198 SLC38A2 - Sodium-coupled neutral amino acid transporter 2 - Bos taurus (Bovine) - SLC38A2 gene Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta (By similarity). Indicus|evm.model.CM009495.1.315 Q9H2H9 S38A1_HUMAN 87.064 0.995604 0.934292 SLC38A1 - Sodium-coupled neutral amino acid transporter 1 - Homo sapiens (Human) - SLC38A1 gene Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. Indicus|evm.model.CM009495.1.317 Q99590 SCAFB_HUMAN 79.850 0.997937 0.993848 SCAF11 - Protein SCAF11 - Homo sapiens (Human) - SCAF11 gene Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. Indicus|evm.model.CM009495.1.318 Q68CP9 ARID2_HUMAN 93.464 0.998891 0.982561 ARID2 - AT-rich interactive domain-containing protein 2 - Homo sapiens (Human) - ARID2 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. Indicus|evm.model.CM009495.1.320 Q17QR5 DBX2_BOVIN 90.294 0.993528 0.908824 DBX2 - Homeobox protein DBX2 - Bos taurus (Bovine) - DBX2 gene regulation of transcription by RNA polymerase II Indicus|evm.model.CM009495.1.321 A6QR11 NELL2_BOVIN 100.000 0.997552 1.00123 NELL2 - Protein kinase C-binding protein NELL2 precursor - Bos taurus (Bovine) - NELL2 gene cytoplasm, heparin binding, protein kinase C binding Indicus|evm.model.CM009495.1.322 Q9H0C3 TM117_HUMAN 97.276 0.996117 1.00195 TMEM117 - Transmembrane protein 117 - Homo sapiens (Human) - TMEM117 gene Involved in endoplasmic reticulum (ER) stress-induced cell death pathway. Indicus|evm.model.CM009495.1.323 Q56JV6 TWF1_BOVIN 100.000 0.906494 1.1 TWF1 - Twinfilin-1 - Bos taurus (Bovine) - TWF1 gene Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). Indicus|evm.model.CM009495.1.324 Q1RMT8 IRAK4_BOVIN 100.000 0.995671 1.00217 IRAK4 - Interleukin-1 receptor-associated kinase 4 - Bos taurus (Bovine) - IRAK4 gene Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections (By similarity). Indicus|evm.model.CM009495.1.325 Q9H0K6 PUS7L_HUMAN 83.167 0.969529 1.02996 PUS7L - Pseudouridylate synthase 7 homolog-like protein - Homo sapiens (Human) - PUS7L gene Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Indicus|evm.model.CM009495.1.326 P59511 ATS20_MOUSE 79.636 0.957649 0.60703 Adamts20 - A disintegrin and metalloproteinase with thrombospondin motifs 20 precursor - Mus musculus (Mouse) - Adamts20 gene May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain. Indicus|evm.model.CM009495.1.327 Q96EY1 DNJA3_HUMAN 86.406 0.604749 1.49167 DNAJA3 - DnaJ homolog subfamily A member 3, mitochondrial precursor - Homo sapiens (Human) - DNAJA3 gene Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Indicus|evm.model.CM009495.1.329 Q56NI9 ESCO2_HUMAN 80.952 0.873239 0.118136 ESCO2 - N-acetyltransferase ESCO2 - Homo sapiens (Human) - ESCO2 gene Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). Indicus|evm.model.CM009495.1.330 Q56NI9 ESCO2_HUMAN 90.370 0.985075 0.222962 ESCO2 - N-acetyltransferase ESCO2 - Homo sapiens (Human) - ESCO2 gene Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). Indicus|evm.model.CM009495.1.331 O15145 ARPC3_HUMAN 59.633 0.974026 0.432584 ARPC3 - Actin-related protein 2/3 complex subunit 3 - Homo sapiens (Human) - ARPC3 gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Indicus|evm.model.CM009495.1.332 Q96MT3 PRIC1_HUMAN 96.279 0.923418 1.08424 PRICKLE1 - Prickle-like protein 1 precursor - Homo sapiens (Human) - PRICKLE1 gene Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. Indicus|evm.model.CM009495.1.333 Q8NEY8 PPHLN_HUMAN 90.852 0.816062 0.842795 PPHLN1 - Periphilin-1 - Homo sapiens (Human) - PPHLN1 gene Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). Indicus|evm.model.CM009495.1.334 Q56JZ7 ZCRB1_BOVIN 100.000 0.990826 1.00461 ZCRB1 - Zinc finger CCHC-type and RNA-binding motif-containing protein 1 - Bos taurus (Bovine) - ZCRB1 gene U12-type spliceosomal complex, mRNA splicing, via spliceosome Indicus|evm.model.CM009495.1.335 Q8IY57 YAF2_HUMAN 100.000 0.984615 0.722222 YAF2 - YY1-associated factor 2 - Homo sapiens (Human) - YAF2 gene Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. Indicus|evm.model.CM009495.1.336 Q4G148 GXLT1_HUMAN 91.818 0.995465 1.00227 GXYLT1 - Glucoside xylosyltransferase 1 - Homo sapiens (Human) - GXYLT1 gene Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose. Indicus|evm.model.CM009495.1.337 Q96I25 SPF45_HUMAN 72.043 0.910891 0.25187 RBM17 - Splicing factor 45 - Homo sapiens (Human) - RBM17 gene Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. Indicus|evm.model.CM009495.1.338 Q6ZMN7 PZRN4_HUMAN 91.824 0.953453 0.642857 PDZRN4 - PDZ domain-containing RING finger protein 4 - Homo sapiens (Human) - PDZRN4 gene Indicus|evm.model.CM009495.1.339 Q6ZMN7 PZRN4_HUMAN 86.861 0.883117 0.148649 PDZRN4 - PDZ domain-containing RING finger protein 4 - Homo sapiens (Human) - PDZRN4 gene Indicus|evm.model.CM009495.1.342 Q28106 CNTN1_BOVIN 99.804 0.998037 1.00098 CNTN1 - Contactin-1 precursor - Bos taurus (Bovine) - CNTN1 gene Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). Indicus|evm.model.CM009495.1.343 P98091 MUCS_BOVIN 98.964 0.534819 0.637655 Submaxillary mucin-like protein - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.346 Q7Z5P9 MUC19_HUMAN 81.159 0.931718 0.108302 MUC19 - Mucin-19 precursor - Homo sapiens (Human) - MUC19 gene May function in ocular mucus homeostasis. Indicus|evm.model.CM009495.1.347 P09651 ROA1_HUMAN 97.333 0.986755 0.405914 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Homo sapiens (Human) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). Indicus|evm.model.CM009495.1.348 Q7Z5P9 MUC19_HUMAN 65.099 0.657033 0.0619036 MUC19 - Mucin-19 precursor - Homo sapiens (Human) - MUC19 gene May function in ocular mucus homeostasis. Indicus|evm.model.CM009495.1.349 Q5S007 LRRK2_HUMAN 90.783 0.999209 1.0004 LRRK2 - Leucine-rich repeat serine/threonine-protein kinase 2 - Homo sapiens (Human) - LRRK2 gene Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, autophagy, and vesicle trafficking (PubMed:20949042, PubMed:22012985, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:30635421, PubMed:21850687, PubMed:23395371, PubMed:17114044, PubMed:24687852, PubMed:26014385, PubMed:25201882). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421, PubMed:23395371). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Independent of its kinase activity, inhibits the proteosomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29212815). Indicus|evm.model.CM009495.1.350 Q96QE2 MYCT_HUMAN 96.774 0.906863 0.314815 SLC2A13 - Proton myo-inositol cotransporter - Homo sapiens (Human) - SLC2A13 gene H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374). Indicus|evm.model.CM009495.1.352 Q86WS4 CL040_HUMAN 63.144 0.916244 0.604294 C12orf40 - Uncharacterized protein C12orf40 - Homo sapiens (Human) - C12orf40 gene Indicus|evm.model.CM009495.1.353 Q9UBJ2 ABCD2_HUMAN 94.340 0.997305 1.0027 ABCD2 - ATP-binding cassette sub-family D member 2 - Homo sapiens (Human) - ABCD2 gene Probable transporter. Indicus|evm.model.CM009495.1.354 P19483 ATPA_BOVIN 75.734 0.980263 0.824593 ATP5F1A - ATP synthase subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1A gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). Indicus|evm.model.CM009495.1.355 Q7Z4S6 KI21A_HUMAN 94.567 0.998797 0.992832 KIF21A - Kinesin-like protein KIF21A - Homo sapiens (Human) - KIF21A gene Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. Indicus|evm.model.CM009495.1.356 Q28554 G3P_SHEEP 87.805 0.975904 0.257764 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Ovis aries (Sheep) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Indicus|evm.model.CM009495.1.357 P10096 G3P_BOVIN 90.863 0.989899 0.594595 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Bos taurus (Bovine) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Indicus|evm.model.CM009495.1.358 Q86YQ8 CPNE8_HUMAN 83.688 0.972167 0.891844 CPNE8 - Copine-8 - Homo sapiens (Human) - CPNE8 gene Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Indicus|evm.model.CM009495.1.359 Q923L3 CSMD1_MOUSE 73.404 0.553571 0.047138 Csmd1 - CUB and sushi domain-containing protein 1 precursor - Mus musculus (Mouse) - Csmd1 gene conditioned place preference, female gonad development, glucose homeostasis, male gonad development, mammary gland branching involved in pregnancy, memory, oviduct epithelium development, startle response Indicus|evm.model.CM009495.1.360 Q15256 PTPRR_HUMAN 92.998 0.996951 0.998478 PTPRR - Receptor-type tyrosine-protein phosphatase R precursor - Homo sapiens (Human) - PTPRR gene Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity). Indicus|evm.model.CM009495.1.361 P23467 PTPRB_HUMAN 87.506 0.880478 1.1312 PTPRB - Receptor-type tyrosine-protein phosphatase beta precursor - Homo sapiens (Human) - PTPRB gene Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). Indicus|evm.model.CM009495.1.362 Q86W47 KCMB4_HUMAN 99.048 0.990521 1.00476 KCNMB4 - Calcium-activated potassium channel subunit beta-4 - Homo sapiens (Human) - KCNMB4 gene Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. Indicus|evm.model.CM009495.1.363 Q9NZN8 CNOT2_HUMAN 100.000 0.996303 1.00185 CNOT2 - CCR4-NOT transcription complex subunit 2 - Homo sapiens (Human) - CNOT2 gene Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. Indicus|evm.model.CM009495.1.365 F1N4M2 MRFL_BOVIN 94.395 0.959206 1.01228 MYRFL - Myelin regulatory factor-like protein - Bos taurus (Bovine) - MYRFL gene endoplasmic reticulum membrane, nucleus, DNA-binding transcription factor activity, sequence-specific DNA binding, positive regulation of transcription, DNA-templated, protein autoprocessing Indicus|evm.model.CM009495.1.366 Q96QF0 RAB3I_HUMAN 96.304 0.995662 0.968487 RAB3IP - Rab-3A-interacting protein - Homo sapiens (Human) - RAB3IP gene Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Indicus|evm.model.CM009495.1.367 Q8N1M1 BEST3_HUMAN 76.127 0.933014 0.938623 BEST3 - Bestrophin-3 - Homo sapiens (Human) - BEST3 gene Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Indicus|evm.model.CM009495.1.368 Q24K06 LRC10_BOVIN 100.000 0.992832 1.0036 LRRC10 - Leucine-rich repeat-containing protein 10 - Bos taurus (Bovine) - LRRC10 gene May play important roles in cardiac development and/or cardiac function. Indicus|evm.model.CM009495.1.369 Q3ZBH0 TCPB_BOVIN 100.000 0.979478 1.00187 CCT2 - T-complex protein 1 subunit beta - Bos taurus (Bovine) - CCT2 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.CM009495.1.370 Q8WU20 FRS2_HUMAN 98.228 0.996071 1.00197 FRS2 - Fibroblast growth factor receptor substrate 2 - Homo sapiens (Human) - FRS2 gene Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. Indicus|evm.model.CM009495.1.371 Q9CR11 YETS4_MOUSE 99.559 0.991228 1.00441 Yeats4 - YEATS domain-containing protein 4 - Mus musculus (Mouse) - Yeats4 gene Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (By similarity). Also able to recognize and bind crotonylated histone H3 (By similarity). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (By similarity). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (By similarity). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (PubMed:29900004). Indicus|evm.model.CM009495.1.372 Q6B411 LYSM_BOVIN 99.324 0.986577 1.00676 Lysozyme C, milk isozyme precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.373 Q27996 LYSCT_BOVIN 91.837 0.986486 1.0068 Lysozyme C, tracheal isozyme precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.374 Q27996 LYSCT_BOVIN 97.279 0.874251 1.13605 Lysozyme C, tracheal isozyme precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.375 Q6B411 LYSM_BOVIN 83.761 0.75817 1.03378 Lysozyme C, milk isozyme precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.376 Q27996 LYSCT_BOVIN 93.197 0.874251 1.13605 Lysozyme C, tracheal isozyme precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.377 Q6B410 LYSI_BOVIN 99.320 0.986486 1.0068 Lysozyme C, intestinal isozyme precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.378 Q06283 LYSC2_BOVIN 100.000 0.986486 1.0068 LYZ2 - Lysozyme C-2 precursor - Bos taurus (Bovine) - LYZ2 gene Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Indicus|evm.model.CM009495.1.379 Q06285 LYSC1_BOVIN 100.000 0.986486 1.0068 LYZ1 - Lysozyme C-1 precursor - Bos taurus (Bovine) - LYZ1 gene Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Indicus|evm.model.CM009495.1.380 Q06284 LYSC3_BOVIN 100.000 0.986486 1.0068 LYZ3 - Lysozyme C-3 precursor - Bos taurus (Bovine) - LYZ3 gene Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Indicus|evm.model.CM009495.1.381 P80189 LYSCN_BOVIN 100.000 0.986577 1.00676 LYS - Lysozyme C, non-stomach isozyme precursor - Bos taurus (Bovine) - LYS gene Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Indicus|evm.model.CM009495.1.382 Q16630 CPSF6_HUMAN 93.548 0.99661 1.07078 CPSF6 - Cleavage and polyadenylation specificity factor subunit 6 - Homo sapiens (Human) - CPSF6 gene Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460). Indicus|evm.model.CM009495.1.383 Q5RFD6 CBPM_PONAB 83.916 0.963883 1 CPM - Carboxypeptidase M precursor - Pongo abelii (Sumatran orangutan) - CPM gene Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins (By similarity). Indicus|evm.model.CM009495.1.384 P56951 MDM2_HORSE 100.000 0.995935 1.00204 MDM2 - E3 ubiquitin-protein ligase Mdm2 - Equus caballus (Horse) - MDM2 gene E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells. Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (By similarity). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (By similarity). Indicus|evm.model.CM009495.1.385 A4IFK2 S35E3_BOVIN 100.000 0.993631 1.00319 SLC35E3 - Solute carrier family 35 member E3 - Bos taurus (Bovine) - SLC35E3 gene Putative transporter. Indicus|evm.model.CM009495.1.386 P57740 NU107_HUMAN 94.264 0.99676 1.00108 NUP107 - Nuclear pore complex protein Nup107 - Homo sapiens (Human) - NUP107 gene Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). Indicus|evm.model.CM009495.1.387 Q5RDM6 RAP1B_PONAB 100.000 0.989189 1.00543 RAP1B - Ras-related protein Rap-1b precursor - Pongo abelii (Sumatran orangutan) - RAP1B gene GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity). Indicus|evm.model.CM009495.1.388 Q5RC32 MDM1_PONAB 81.155 0.997241 1.00138 MDM1 - Nuclear protein MDM1 - Pongo abelii (Sumatran orangutan) - MDM1 gene Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules. Indicus|evm.model.CM009495.1.389 Q9GZX6 IL22_HUMAN 70.950 0.931937 1.06704 IL22 - Interleukin-22 precursor - Homo sapiens (Human) - IL22 gene Cytokine that contributes to the inflammatory response in vivo. Indicus|evm.model.CM009495.1.390 P46791 RS2_CRIGR 62.069 0.816456 0.782178 RPS2 - 40S ribosomal protein S2 - Cricetulus griseus (Chinese hamster) - RPS2 gene Indicus|evm.model.CM009495.1.391 Q9NPH9 IL26_HUMAN 86.391 0.669323 1.46784 IL26 - Interleukin-26 precursor - Homo sapiens (Human) - IL26 gene May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. Indicus|evm.model.CM009495.1.392 P07353 IFNG_BOVIN 100.000 0.705556 1.08434 IFNG - Interferon gamma precursor - Bos taurus (Bovine) - IFNG gene Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity). Indicus|evm.model.CM009495.1.393 Q92630 DYRK2_HUMAN 98.502 0.996667 0.998336 DYRK2 - Dual specificity tyrosine-phosphorylation-regulated kinase 2 - Homo sapiens (Human) - DYRK2 gene Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). Indicus|evm.model.CM009495.1.394 Q86VP6 CAND1_HUMAN 100.000 0.998375 1.00081 CAND1 - Cullin-associated NEDD8-dissociated protein 1 - Homo sapiens (Human) - CAND1 gene Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. Indicus|evm.model.CM009495.1.395 Q9Y3R0 GRIP1_HUMAN 90.631 0.998082 0.924645 GRIP1 - Glutamate receptor-interacting protein 1 - Homo sapiens (Human) - GRIP1 gene May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Indicus|evm.model.CM009495.1.396 Q8NG08 HELB_HUMAN 74.954 0.998145 0.99172 HELB - DNA helicase B - Homo sapiens (Human) - HELB gene 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). Indicus|evm.model.CM009495.1.397 Q9Y616 IRAK3_HUMAN 82.940 0.946644 0.974832 IRAK3 - Interleukin-1 receptor-associated kinase 3 - Homo sapiens (Human) - IRAK3 gene Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). Indicus|evm.model.CM009495.1.398 Q9HC24 LFG4_HUMAN 85.714 0.991632 1.0042 TMBIM4 - Protein lifeguard 4 - Homo sapiens (Human) - TMBIM4 gene Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release. Indicus|evm.model.CM009495.1.399 Q2TBR9 CL031_BOVIN 100.000 0.984375 1.00787 Uncharacterized protein C12orf31 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.401 Q8IXL7 MSRB3_HUMAN 91.925 0.859459 0.963542 MSRB3 - Methionine-R-sulfoxide reductase B3 precursor - Homo sapiens (Human) - MSRB3 gene Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. Indicus|evm.model.CM009495.1.402 Q9Y2U8 MAN1_HUMAN 83.370 0.997619 0.922064 LEMD3 - Inner nuclear membrane protein Man1 - Homo sapiens (Human) - LEMD3 gene Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. Indicus|evm.model.CM009495.1.403 Q9WUA1 WIF1_MOUSE 93.333 0.864734 0.546174 Wif1 - Wnt inhibitory factor 1 precursor - Mus musculus (Mouse) - Wif1 gene Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. Indicus|evm.model.CM009495.1.404 Q9Y2I9 TBC30_HUMAN 86.406 0.947503 0.845238 TBC1D30 - TBC1 domain family member 30 - Homo sapiens (Human) - TBC1D30 gene GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro. Indicus|evm.model.CM009495.1.405 Q8IUQ4 SIAH1_HUMAN 84.752 0.728495 1.31915 SIAH1 - E3 ubiquitin-protein ligase SIAH1 - Homo sapiens (Human) - SIAH1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:10747903, PubMed:11146551, PubMed:11389839, PubMed:11389840, PubMed:11483517, PubMed:11483518, PubMed:11752454, PubMed:12072443). Confers constitutive instability to HIPK2 through proteasomal degradation (PubMed:18536714). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Has some overlapping function with SIAH2 (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (By similarity). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Indicus|evm.model.CM009495.1.406 Q9Y2I9 TBC30_HUMAN 72.430 0.931707 0.221861 TBC1D30 - TBC1 domain family member 30 - Homo sapiens (Human) - TBC1D30 gene GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro. Indicus|evm.model.CM009495.1.407 Q1LZH9 GNS_BOVIN 99.466 0.996448 1.00536 GNS - N-acetylglucosamine-6-sulfatase precursor - Bos taurus (Bovine) - GNS gene glycosaminoglycan binding, N-acetylglucosamine-6-sulfatase activity Indicus|evm.model.CM009495.1.408 Q99P51 RASF3_MOUSE 89.677 0.855556 0.775862 Rassf3 - Ras association domain-containing protein 3 - Mus musculus (Mouse) - Rassf3 gene cytoplasm, cytosol, plasma membrane, identical protein binding, signal transduction Indicus|evm.model.CM009495.1.409 Q9UHD2 TBK1_HUMAN 97.119 0.99726 1.00137 TBK1 - Serine/threonine-protein kinase TBK1 - Homo sapiens (Human) - TBK1 gene Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:10581243, PubMed:11839743, PubMed:15485837, PubMed:21138416, PubMed:25636800, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:26611359, PubMed:32404352). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Indicus|evm.model.CM009495.1.410 O43592 XPOT_HUMAN 99.064 0.997923 1.00104 XPOT - Exportin-T - Homo sapiens (Human) - XPOT gene Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Indicus|evm.model.CM009495.1.411 Q8IXR9 CL056_HUMAN 82.986 0.985692 1.01125 C12orf56 - Uncharacterized protein C12orf56 - Homo sapiens (Human) - C12orf56 gene Indicus|evm.model.CM009495.1.412 Q96MD2 CL066_HUMAN 97.079 0.995516 1.00225 KICS2 - KICSTOR subunit 2 - Homo sapiens (Human) - KICS2 gene As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. Indicus|evm.model.CM009495.1.413 Q7Z6B7 SRGP1_HUMAN 98.065 0.998158 1.00092 SRGAP1 - SLIT-ROBO Rho GTPase-activating protein 1 - Homo sapiens (Human) - SRGAP1 gene GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. Indicus|evm.model.CM009495.1.414 Q9Y2B1 RXLT1_HUMAN 85.779 0.995485 1 RXYLT1 - Ribitol-5-phosphate xylosyltransferase 1 - Homo sapiens (Human) - RXYLT1 gene UDP-xylosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:27601598, PubMed:27733679) (Probable). Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan (PubMed:27733679, PubMed:29477842) (Probable). Indicus|evm.model.CM009495.1.416 P48043 V1AR_SHEEP 94.568 0.950588 1.01675 AVPR1A - Vasopressin V1a receptor - Ovis aries (Sheep) - AVPR1A gene Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Indicus|evm.model.CM009495.1.417 Q3UYC0 PPM1H_MOUSE 96.887 0.996117 1.0039 Ppm1h - Protein phosphatase 1H - Mus musculus (Mouse) - Ppm1h gene Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. Indicus|evm.model.CM009495.1.419 Q7Z3U7 MON2_HUMAN 97.442 0.998834 0.998835 MON2 - Protein MON2 homolog - Homo sapiens (Human) - MON2 gene Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. Indicus|evm.model.CM009495.1.420 Q9Y4E8 UBP15_HUMAN 98.675 0.997963 1.00102 USP15 - Ubiquitin carboxyl-terminal hydrolase 15 - Homo sapiens (Human) - USP15 gene Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:21947082, PubMed:22344298, PubMed:24852371, PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). Indicus|evm.model.CM009495.1.421 A0A1B0GX49 TVB64_HUMAN 63.717 0.861538 1.14035 TRBV6-4 - T cell receptor beta variable 6-4 precursor - Homo sapiens (Human) - TRBV6-4 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009495.1.422 Q5RCP8 H2B2E_PONAB 85.294 0.971154 0.825397 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009495.1.425 O02751 CFDP2_BOVIN 81.818 0.9375 0.216216 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Indicus|evm.model.CM009495.1.426 O60669 MOT2_HUMAN 79.545 0.995859 1.01046 SLC16A7 - Monocarboxylate transporter 2 - Homo sapiens (Human) - SLC16A7 gene Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter. Indicus|evm.model.CM009495.1.427 P19483 ATPA_BOVIN 89.589 0.994048 0.607595 ATP5F1A - ATP synthase subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1A gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). Indicus|evm.model.CM009495.1.428 P19483 ATPA_BOVIN 97.368 0.883041 0.309222 ATP5F1A - ATP synthase subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1A gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). Indicus|evm.model.CM009495.1.430 Q6IV78 TAZ_SAISC 97.122 0.816568 0.645038 TAZ - Tafazzin - Saimiri sciureus (Common squirrel monkey) - TAZ gene Acyltransferase which is required to maintain the composition of the phospholipid cardiolipin, a key component of the mitochondrial inner membrane (By similarity). Required for the initiation of mitophagy (By similarity). Required to ensure progression of spermatocytes through meiosis (By similarity). Indicus|evm.model.CM009495.1.431 Q6UXM1 LRIG3_HUMAN 89.008 0.998174 0.978552 LRIG3 - Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor - Homo sapiens (Human) - LRIG3 gene May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). Indicus|evm.model.CM009495.1.432 Q9Y6H3 ATP23_HUMAN 90.244 0.991903 1.00407 ATP23 - Mitochondrial inner membrane protease ATP23 homolog - Homo sapiens (Human) - ATP23 gene cell junction, cytosol, DNA-dependent protein kinase-DNA ligase 4 complex, extrinsic component of mitochondrial inner membrane, intracellular membrane-bounded organelle, plasma membrane, DNA-dependent protein kinase activity, double-strand break repair via nonhomologous end joining, mitochondrial protein processing, mitochondrial proton-transporting ATP synthase complex assembly Indicus|evm.model.CM009495.1.433 O14595 CTDS2_HUMAN 98.524 0.992647 1.00369 CTDSP2 - Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 - Homo sapiens (Human) - CTDSP2 gene Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. Indicus|evm.model.CM009495.1.434 O75366 AVIL_HUMAN 90.476 0.997552 0.997558 AVIL - Advillin - Homo sapiens (Human) - AVIL gene Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling (PubMed:29058690). May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (PubMed:29058690). Indicus|evm.model.CM009495.1.435 P43896 EFTS_BOVIN 100.000 0.9941 1.00296 TSFM - Elongation factor Ts, mitochondrial precursor - Bos taurus (Bovine) - TSFM gene Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Indicus|evm.model.CM009495.1.436 A4FV98 EFMT3_BOVIN 100.000 0.991189 1.00442 EEF1AKMT3 - EEF1A lysine methyltransferase 3 - Bos taurus (Bovine) - EEF1AKMT3 gene Protein-lysine methyltransferase that selectively methylates EEF1A1 and EEF1A2 at 'Lys-165' in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. Indicus|evm.model.CM009495.1.437 Q2YDF1 TRMB_BOVIN 100.000 0.992806 1.00361 METTL1 - tRNA (guanine-N(7)-)-methyltransferase - Bos taurus (Bovine) - METTL1 gene Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs, such as let-7. N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA). Acts as a regulator of embryonic stem cell self-renewal and differentiation. Indicus|evm.model.CM009495.1.438 O15528 CP27B_HUMAN 88.212 0.996071 1.00197 CYP27B1 - 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor - Homo sapiens (Human) - CYP27B1 gene A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1alpha-position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR) (PubMed:10518789, PubMed:9486994, PubMed:22862690, PubMed:10566658, PubMed:12050193). Has 1alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway (PubMed:10518789, PubMed:22862690). Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2 (PubMed:10518789). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:22862690). Indicus|evm.model.CM009495.1.439 Q3TZ87 MARH9_MOUSE 96.552 0.994236 0.997126 Marchf9 - E3 ubiquitin-protein ligase MARCHF9 - Mus musculus (Mouse) - Marchf9 gene E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Indicus|evm.model.CM009495.1.440 B2MVY4 CDK4_SHEEP 100.000 0.993421 1.0033 Cyclin-dependent kinase 4 - Ovis aries (Sheep) Indicus|evm.model.CM009495.1.441 Q32KP1 TSN31_BOVIN 100.000 0.990521 1.00476 TSPAN31 - Tetraspanin-31 - Bos taurus (Bovine) - TSPAN31 gene integral component of plasma membrane Indicus|evm.model.CM009495.1.442 Q99490 AGAP2_HUMAN 92.953 0.998289 0.980705 AGAP2 - Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 - Homo sapiens (Human) - AGAP2 gene GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. Indicus|evm.model.CM009495.1.443 Q3MHX6 OS9_BOVIN 99.700 0.997006 1.0015 OS9 - Protein OS-9 precursor - Bos taurus (Bovine) - OS9 gene Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity). Indicus|evm.model.CM009495.1.444 Q00973 B4GN1_HUMAN 90.994 0.996255 1.00188 B4GALNT1 - Beta-1,4 N-acetylgalactosaminyltransferase 1 - Homo sapiens (Human) - B4GALNT1 gene Involved in the biosynthesis of gangliosides GM2, GD2, GT2 and GA2 from GM3, GD3, GT3 and GA3, respectively. Indicus|evm.model.CM009495.1.445 Q0P5F7 PI42C_BOVIN 100.000 0.994334 0.83848 PIP4K2C - Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma - Bos taurus (Bovine) - PIP4K2C gene Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3. Indicus|evm.model.CM009495.1.446 Q5REG4 DTX3_PONAB 97.118 0.985755 1.01153 DTX3 - Probable E3 ubiquitin-protein ligase DTX3 - Pongo abelii (Sumatran orangutan) - DTX3 gene Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Indicus|evm.model.CM009495.1.447 Q86VW2 ARHGP_HUMAN 95.255 0.882258 1.06897 ARHGEF25 - Rho guanine nucleotide exchange factor 25 - Homo sapiens (Human) - ARHGEF25 gene May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). Indicus|evm.model.CM009495.1.448 Q5EBI0 S2610_MOUSE 83.307 0.987362 0.936391 Slc26a10 - Solute carrier family 26 member 10 - Mus musculus (Mouse) - Slc26a10 gene Chloride/bicarbonate exchanger. Indicus|evm.model.CM009495.1.449 Q0P5F7 PI42C_BOVIN 98.305 0.816901 0.168646 PIP4K2C - Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma - Bos taurus (Bovine) - PIP4K2C gene Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3. Indicus|evm.model.CM009495.1.450 Q12840 KIF5A_HUMAN 98.934 0.998064 1.00097 KIF5A - Kinesin heavy chain isoform 5A - Homo sapiens (Human) - KIF5A gene Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. Indicus|evm.model.CM009495.1.451 Q3ZCF0 DCTN2_BOVIN 100.000 0.99505 1.00248 DCTN2 - Dynactin subunit 2 - Bos taurus (Bovine) - DCTN2 gene Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). Indicus|evm.model.CM009495.1.452 Q96DN6 MBD6_HUMAN 94.836 0.998016 1.00499 MBD6 - Methyl-CpG-binding domain protein 6 - Homo sapiens (Human) - MBD6 gene Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro). Indicus|evm.model.CM009495.1.453 Q0IIB6 DDIT3_BOVIN 100.000 0.988166 1.00595 DDIT3 - DNA damage-inducible transcript 3 protein - Bos taurus (Bovine) - DDIT3 gene Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (By similarity). Indicus|evm.model.CM009495.1.454 Q2T9L8 SYMC_BOVIN 99.889 0.997775 1.00111 MARS1 - Methionine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - MARS1 gene Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus. Indicus|evm.model.CM009495.1.455 Q9BRR9 RHG09_HUMAN 81.950 0.997301 0.988 ARHGAP9 - Rho GTPase-activating protein 9 - Homo sapiens (Human) - ARHGAP9 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. Indicus|evm.model.CM009495.1.456 P08151 GLI1_HUMAN 89.879 0.998143 0.973779 GLI1 - Zinc finger protein GLI1 - Homo sapiens (Human) - GLI1 gene Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). Indicus|evm.model.CM009495.1.457 P58166 INHBE_HUMAN 82.051 0.994269 0.997143 INHBE - Inhibin beta E chain precursor - Homo sapiens (Human) - INHBE gene Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Indicus|evm.model.CM009495.1.458 P55103 INHBC_HUMAN 79.464 0.949008 1.00284 INHBC - Inhibin beta C chain precursor - Homo sapiens (Human) - INHBC gene Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Indicus|evm.model.CM009495.1.459 Q9Y2K5 R3HD2_HUMAN 96.863 0.508459 1.09016 R3HDM2 - R3H domain-containing protein 2 - Homo sapiens (Human) - R3HDM2 gene RNA binding Indicus|evm.model.CM009495.1.460 Q96MF2 STAC3_HUMAN 96.429 0.99449 0.997253 STAC3 - SH3 and cysteine-rich domain-containing protein 3 - Homo sapiens (Human) - STAC3 gene Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335). Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335). Indicus|evm.model.CM009495.1.461 Q3SZ44 NUA4L_BOVIN 100.000 0.977273 1.01149 NDUFA4L2 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 - Bos taurus (Bovine) - NDUFA4L2 gene mitochondrial respiratory chain complex IV Indicus|evm.model.CM009495.1.462 Q3SZ20 GLYM_BOVIN 100.000 0.99604 1.00198 SHMT2 - Serine hydroxymethyltransferase, mitochondrial precursor - Bos taurus (Bovine) - SHMT2 gene Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex. Indicus|evm.model.CM009495.1.463 O95158 NXPH4_HUMAN 85.374 0.900621 1.04545 NXPH4 - Neurexophilin-4 precursor - Homo sapiens (Human) - NXPH4 gene May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Indicus|evm.model.CM009495.1.464 Q07954 LRP1_HUMAN 98.041 0.99956 0.99956 LRP1 - Prolow-density lipoprotein receptor-related protein 1 precursor - Homo sapiens (Human) - LRP1 gene Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). Indicus|evm.model.CM009495.1.465 Q4GWZ2 RSSA_PIG 82.569 0.981818 0.372881 RPSA - 40S ribosomal protein SA - Sus scrofa (Pig) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. Indicus|evm.model.CM009495.1.466 P42226 STAT6_HUMAN 92.798 0.997642 1.00118 STAT6 - Signal transducer and activator of transcription 6 - Homo sapiens (Human) - STAT6 gene Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. Indicus|evm.model.CM009495.1.467 Q15742 NAB2_HUMAN 98.286 0.996198 1.0019 NAB2 - NGFI-A-binding protein 2 - Homo sapiens (Human) - NAB2 gene Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). Indicus|evm.model.CM009495.1.468 A7MBC7 NEMP1_BOVIN 92.568 0.993274 1.00225 NEMP1 - Nuclear envelope integral membrane protein 1 precursor - Bos taurus (Bovine) - NEMP1 gene nuclear envelope Indicus|evm.model.CM009495.1.469 P10568 MYO1A_BOVIN 99.230 0.855025 1.16395 MYO1A - Unconventional myosin-Ia - Bos taurus (Bovine) - MYO1A gene Involved in directing the movement of organelles along actin filaments. Indicus|evm.model.CM009495.1.470 O15060 ZBT39_HUMAN 92.837 0.997175 0.994382 ZBTB39 - Zinc finger and BTB domain-containing protein 39 - Homo sapiens (Human) - ZBTB39 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009495.1.471 O15218 GP182_HUMAN 79.275 0.977157 0.975248 GPR182 - G-protein coupled receptor 182 - Homo sapiens (Human) - GPR182 gene Orphan receptor. Indicus|evm.model.CM009495.1.472 O14756 H17B6_HUMAN 80.952 0.10199 1.26814 HSD17B6 - 17-beta-hydroxysteroid dehydrogenase type 6 precursor - Homo sapiens (Human) - HSD17B6 gene NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. Indicus|evm.model.CM009495.1.473 O75452 RDH16_HUMAN 73.502 0.993485 0.968454 RDH16 - Retinol dehydrogenase 16 - Homo sapiens (Human) - RDH16 gene Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:9677409, PubMed:29541409). Indicus|evm.model.CM009495.1.474 O75452 RDH16_HUMAN 79.495 0.993711 1.00315 RDH16 - Retinol dehydrogenase 16 - Homo sapiens (Human) - RDH16 gene Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:9677409, PubMed:29541409). Indicus|evm.model.CM009495.1.475 Q3T001 H17B6_BOVIN 76.562 0.636364 0.312303 HSD17B6 - 17-beta-hydroxysteroid dehydrogenase type 6 precursor - Bos taurus (Bovine) - HSD17B6 gene NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids (By similarity). Indicus|evm.model.CM009495.1.476 A4IFM3 DR9C7_BOVIN 99.681 0.993631 1.00319 SDR9C7 - Short-chain dehydrogenase/reductase family 9C member 7 - Bos taurus (Bovine) - SDR9C7 gene Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity (By similarity). Indicus|evm.model.CM009495.1.477 O75452 RDH16_HUMAN 60.261 0.979933 0.943218 RDH16 - Retinol dehydrogenase 16 - Homo sapiens (Human) - RDH16 gene Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:9677409, PubMed:29541409). Indicus|evm.model.CM009495.1.478 Q3T001 H17B6_BOVIN 99.369 0.993711 1.00315 HSD17B6 - 17-beta-hydroxysteroid dehydrogenase type 6 precursor - Bos taurus (Bovine) - HSD17B6 gene NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids (By similarity). Indicus|evm.model.CM009495.1.479 P49642 PRI1_HUMAN 85.909 0.995444 1.04524 PRIM1 - DNA primase small subunit - Homo sapiens (Human) - PRIM1 gene Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:9268648, PubMed:9705292, PubMed:17893144). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Can add both ribo- and deoxynucleotides during elongation of the primers (By similarity). Binds single stranded DNA (By similarity). Indicus|evm.model.CM009495.1.480 Q5E9A1 NACA_BOVIN 100.000 0.990741 1.00465 NACA - Nascent polypeptide-associated complex subunit alpha - Bos taurus (Bovine) - NACA gene Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. Indicus|evm.model.CM009495.1.481 G1TGF1 TEBP_RABIT 98.077 0.587121 1.65 PTGES3 - Prostaglandin E synthase 3 - Oryctolagus cuniculus (Rabbit) - PTGES3 gene Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. Indicus|evm.model.CM009495.1.482 P00829 ATPB_BOVIN 100.000 0.996219 1.00189 ATP5F1B - ATP synthase subunit beta, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1B gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Indicus|evm.model.CM009495.1.483 Q9UIF9 BAZ2A_HUMAN 91.081 0.998946 0.995801 BAZ2A - Bromodomain adjacent to zinc finger domain protein 2A - Homo sapiens (Human) - BAZ2A gene Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). Indicus|evm.model.CM009495.1.484 Q3ZC34 RBMS2_BOVIN 100.000 0.995098 1.00246 RBMS2 - RNA-binding motif, single-stranded-interacting protein 2 - Bos taurus (Bovine) - RBMS2 gene cytosol, nucleus, ribonucleoprotein complex, mRNA 3'-UTR binding, poly(A) binding, poly(U) RNA binding, RNA binding Indicus|evm.model.CM009495.1.485 Q9UI32 GLSL_HUMAN 95.017 0.996683 1.00166 GLS2 - Glutaminase liver isoform, mitochondrial precursor - Homo sapiens (Human) - GLS2 gene Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. Indicus|evm.model.CM009495.1.486 Q8WW59 SPRY4_HUMAN 90.338 0.990385 1.00483 SPRYD4 - SPRY domain-containing protein 4 - Homo sapiens (Human) - SPRYD4 gene nucleus Indicus|evm.model.CM009495.1.487 P06624 MIP_BOVIN 100.000 0.992424 1.0038 MIP - Lens fiber major intrinsic protein - Bos taurus (Bovine) - MIP gene Water channel (PubMed:23893133). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling. Indicus|evm.model.CM009495.1.488 Q9UNS1 TIM_HUMAN 87.264 0.996705 1.00497 TIMELESS - Protein timeless homolog - Homo sapiens (Human) - TIMELESS gene Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:9856465, PubMed:17141802, PubMed:17296725, PubMed:23418588, PubMed:26344098). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). Indicus|evm.model.CM009495.1.490 O02799 STAT2_PIG 83.565 0.707438 1.40046 STAT2 - Signal transducer and activator of transcription 2 - Sus scrofa (Pig) - STAT2 gene Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively. Indicus|evm.model.CM009495.1.491 Q9N2H9 IL23A_PIG 86.979 0.984456 1 IL23A - Interleukin-23 subunit alpha precursor - Sus scrofa (Pig) - IL23A gene Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity). Indicus|evm.model.CM009495.1.492 Q504Q3 PAN2_HUMAN 97.671 0.998332 0.997504 PAN2 - PAN2-PAN3 deadenylation complex catalytic subunit PAN2 - Homo sapiens (Human) - PAN2 gene Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. Indicus|evm.model.CM009495.1.493 Q9Y2B0 CNPY2_HUMAN 98.901 0.989071 1.00549 CNPY2 - Protein canopy homolog 2 precursor - Homo sapiens (Human) - CNPY2 gene Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. Indicus|evm.model.CM009495.1.494 Q29RK1 CISY_BOVIN 100.000 0.995717 1.00215 CS - Citrate synthase, mitochondrial precursor - Bos taurus (Bovine) - CS gene mitochondrial matrix, citrate (Si)-synthase activity, carbohydrate metabolic process, tricarboxylic acid cycle Indicus|evm.model.CM009495.1.495 Q96MF6 CQ10A_HUMAN 93.103 0.985366 0.82996 COQ10A - Coenzyme Q-binding protein COQ10 homolog A, mitochondrial precursor - Homo sapiens (Human) - COQ10A gene Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable). Indicus|evm.model.CM009495.1.496 Q8NB46 ANR52_HUMAN 99.160 0.951957 1.04461 ANKRD52 - Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C - Homo sapiens (Human) - ANKRD52 gene Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Indicus|evm.model.CM009495.1.497 Q6ZMH5 S39A5_HUMAN 83.549 0.883797 1.13148 SLC39A5 - Zinc transporter ZIP5 precursor - Homo sapiens (Human) - SLC39A5 gene May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport (By similarity). Seems to play a central role in controlling organismal zinc status (By similarity). Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Plays a role in eye development (PubMed:24891338). Indicus|evm.model.CM009495.1.498 A6QLK2 SOSB1_BOVIN 100.000 0.990566 1.00474 NABP2 - SOSS complex subunit B1 - Bos taurus (Bovine) - NABP2 gene Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). Indicus|evm.model.CM009495.1.499 Q5R7T5 RNF41_PONAB 91.483 0.993151 0.921136 RNF41 - E3 ubiquitin-protein ligase NRDP1 - Pongo abelii (Sumatran orangutan) - RNF41 gene Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. Indicus|evm.model.CM009495.1.500 Q8TAQ2 SMRC2_HUMAN 95.710 0.947368 1.0486 SMARCC2 - SWI/SNF complex subunit SMARCC2 - Homo sapiens (Human) - SMARCC2 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). Indicus|evm.model.CM009495.1.501 Q64119 MYL6_RAT 99.333 0.412742 2.39073 Myl6 - Myosin light polypeptide 6 - Rattus norvegicus (Rat) - Myl6 gene Regulatory light chain of myosin. Does not bind calcium. Indicus|evm.model.CM009495.1.502 Q5RAG2 ESYT1_PONAB 90.191 0.99187 1.00272 ESYT1 - Extended synaptotagmin-1 - Pongo abelii (Sumatran orangutan) - ESYT1 gene Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Indicus|evm.model.CM009495.1.503 Q96K80 ZC3HA_HUMAN 97.241 0.995413 1.00461 ZC3H10 - Zinc finger CCCH domain-containing protein 10 - Homo sapiens (Human) - ZC3H10 gene Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA. Indicus|evm.model.CM009495.1.504 Q9UQ80 PA2G4_HUMAN 99.746 0.994937 1.00254 PA2G4 - Proliferation-associated protein 2G4 - Homo sapiens (Human) - PA2G4 gene May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). Indicus|evm.model.CM009495.1.505 P21860 ERBB3_HUMAN 93.661 0.997756 0.996274 ERBB3 - Receptor tyrosine-protein kinase erbB-3 precursor - Homo sapiens (Human) - ERBB3 gene Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). Indicus|evm.model.CM009495.1.506 Q9H2S9 IKZF4_HUMAN 97.533 0.807988 1.11282 IKZF4 - Zinc finger protein Eos - Homo sapiens (Human) - IKZF4 gene DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). Indicus|evm.model.CM009495.1.507 P51687 SUOX_HUMAN 85.321 0.992701 1.0055 SUOX - Sulfite oxidase, mitochondrial precursor - Homo sapiens (Human) - SUOX gene mitochondrial matrix, mitochondrion, heme binding, molybdopterin cofactor binding, sulfite oxidase activity, sulfide oxidation, using sulfide:quinone oxidoreductase, sulfur compound metabolic process Indicus|evm.model.CM009495.1.508 Q5RBG1 RAB5B_PONAB 99.535 0.990741 1.00465 RAB5B - Ras-related protein Rab-5B - Pongo abelii (Sumatran orangutan) - RAB5B gene Protein transport. Probably involved in vesicular traffic. Indicus|evm.model.CM009495.1.509 Q5E9Y0 CDK2_BOVIN 100.000 0.993311 1.00336 CDK2 - Cyclin-dependent kinase 2 - Bos taurus (Bovine) - CDK2 gene Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity). Indicus|evm.model.CM009495.1.510 Q06154 PMEL_BOVIN 99.306 0.99481 0.890601 PMEL - Melanocyte protein PMEL precursor - Bos taurus (Bovine) - PMEL gene Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures (By similarity). Indicus|evm.model.CM009495.1.511 A0JN54 DGKA_BOVIN 100.000 0.945806 1.05586 DGKA - Diacylglycerol kinase alpha - Bos taurus (Bovine) - DGKA gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol. Indicus|evm.model.CM009495.1.512 A6QPH1 PYM1_BOVIN 100.000 0.990196 1.00493 PYM1 - Partner of Y14 and mago - Bos taurus (Bovine) - PYM1 gene Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity). Indicus|evm.model.CM009495.1.513 Q9CPX9 APC11_MOUSE 62.162 0.972973 0.880952 Anapc11 - Anaphase-promoting complex subunit 11 - Mus musculus (Mouse) - Anapc11 gene Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). Indicus|evm.model.CM009495.1.514 Q99542 MMP19_HUMAN 85.830 0.982 0.984252 MMP19 - Matrix metalloproteinase-19 precursor - Homo sapiens (Human) - MMP19 gene Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. Indicus|evm.model.CM009495.1.515 Q6DFQ7 TM198_XENTR 53.666 0.938547 1.04678 tmem198 - Transmembrane protein 198 - Xenopus tropicalis (Western clawed frog) - tmem198 gene Promotes lrp6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of lrp6 further enhancing its activity. Required for neural crest formation. Indicus|evm.model.CM009495.1.516 Q95J56 DJC14_BOVIN 100.000 0.997143 1.00143 DNAJC14 - DnaJ homolog subfamily C member 14 - Bos taurus (Bovine) - DNAJC14 gene Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity). Promotes cleavage of pestivirus polyprotein. Indicus|evm.model.CM009495.1.517 Q5E972 ORML2_BOVIN 100.000 0.987013 1.00654 ORMDL2 - ORM1-like protein 2 - Bos taurus (Bovine) - ORMDL2 gene Negative regulator of sphingolipid synthesis. Indicus|evm.model.CM009495.1.518 Q5R4V4 SARNP_PONAB 97.143 0.990521 1.00476 SARNP - SAP domain-containing ribonucleoprotein - Pongo abelii (Sumatran orangutan) - SARNP gene Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity). Indicus|evm.model.CM009495.1.519 O95390 GDF11_HUMAN 99.410 0.968481 0.857494 GDF11 - Growth/differentiation factor 11 precursor - Homo sapiens (Human) - GDF11 gene Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634). Indicus|evm.model.CM009495.1.520 Q9XSK2 CD63_BOVIN 100.000 0.991597 1.00422 CD63 - CD63 antigen - Bos taurus (Bovine) - CD63 gene Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity). Indicus|evm.model.CM009495.1.521 Q27979 RDH5_BOVIN 100.000 0.99373 1.00314 RDH5 - Retinol dehydrogenase 5 - Bos taurus (Bovine) - RDH5 gene Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:7544779, PubMed:7836368, PubMed:9654122). Has no activity towards all-trans retinal (PubMed:9654122). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE) (By similarity). Also recognizes steroids (androsterone, androstanediol) as its substrates (By similarity). Indicus|evm.model.CM009495.1.522 Q5R7L8 BL1S1_PONAB 100.000 0.984127 0.823529 BLOC1S1 - Biogenesis of lysosome-related organelles complex 1 subunit 1 - Pongo abelii (Sumatran orangutan) - BLOC1S1 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Indicus|evm.model.CM009495.1.523 Q13683 ITA7_HUMAN 97.449 0.689046 0.239627 ITGA7 - Integrin alpha-7 precursor - Homo sapiens (Human) - ITGA7 gene Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Indicus|evm.model.CM009495.1.524 Q13683 ITA7_HUMAN 94.138 0.798343 0.30652 ITGA7 - Integrin alpha-7 precursor - Homo sapiens (Human) - ITGA7 gene Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Indicus|evm.model.CM009495.1.525 Q13683 ITA7_HUMAN 92.226 0.97079 0.492803 ITGA7 - Integrin alpha-7 precursor - Homo sapiens (Human) - ITGA7 gene Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Indicus|evm.model.CM009495.1.526 Q6UX53 MET7B_HUMAN 86.099 0.906122 1.0041 METTL7B - Methyltransferase-like protein 7B precursor - Homo sapiens (Human) - METTL7B gene Probable methyltransferase. Indicus|evm.model.CM009495.1.527 Q8NGE2 O2AP1_HUMAN 82.278 0.957317 0.530744 OR2AP1 - Olfactory receptor 2AP1 - Homo sapiens (Human) - OR2AP1 gene Odorant receptor. Indicus|evm.model.CM009495.1.528 Q56JY4 TOM6_BOVIN 98.649 0.973333 1.01351 TOMM6 - Mitochondrial import receptor subunit TOM6 homolog - Bos taurus (Bovine) - TOMM6 gene mitochondrion Indicus|evm.model.CM009495.1.529 A6NDL8 O6C68_HUMAN 68.824 0.944134 0.573718 OR6C68 - Olfactory receptor 6C68 - Homo sapiens (Human) - OR6C68 gene Odorant receptor. Indicus|evm.model.CM009495.1.531 Q96RD1 OR6C1_HUMAN 81.911 0.996587 0.939103 OR6C1 - Olfactory receptor 6C1 - Homo sapiens (Human) - OR6C1 gene Odorant receptor. Indicus|evm.model.CM009495.1.532 A6NM76 O6C76_HUMAN 88.144 0.984694 0.628205 OR6C76 - Olfactory receptor 6C76 - Homo sapiens (Human) - OR6C76 gene Odorant receptor. Indicus|evm.model.CM009495.1.533 Q9NZP0 OR6C3_HUMAN 83.275 0.993056 0.926045 OR6C3 - Olfactory receptor 6C3 - Homo sapiens (Human) - OR6C3 gene Odorant receptor. Indicus|evm.model.CM009495.1.534 Q9NZP0 OR6C3_HUMAN 83.871 0.974763 1.01929 OR6C3 - Olfactory receptor 6C3 - Homo sapiens (Human) - OR6C3 gene Odorant receptor. Indicus|evm.model.CM009495.1.535 Q9NZP0 OR6C3_HUMAN 81.935 0.959627 1.03537 OR6C3 - Olfactory receptor 6C3 - Homo sapiens (Human) - OR6C3 gene Odorant receptor. Indicus|evm.model.CM009495.1.537 Q9NZP0 OR6C3_HUMAN 94.881 0.979866 0.958199 OR6C3 - Olfactory receptor 6C3 - Homo sapiens (Human) - OR6C3 gene Odorant receptor. Indicus|evm.model.CM009495.1.538 Q96RD1 OR6C1_HUMAN 86.111 0.310044 0.733974 OR6C1 - Olfactory receptor 6C1 - Homo sapiens (Human) - OR6C1 gene Odorant receptor. Indicus|evm.model.CM009495.1.540 Q96RD1 OR6C1_HUMAN 76.531 0.996454 0.903846 OR6C1 - Olfactory receptor 6C1 - Homo sapiens (Human) - OR6C1 gene Odorant receptor. Indicus|evm.model.CM009495.1.541 Q9NZP0 OR6C3_HUMAN 82.258 0.980952 1.01286 OR6C3 - Olfactory receptor 6C3 - Homo sapiens (Human) - OR6C3 gene Odorant receptor. Indicus|evm.model.CM009495.1.542 Q96KK4 O10C1_HUMAN 57.865 0.988827 0.573718 OR10C1 - Olfactory receptor 10C1 - Homo sapiens (Human) - OR10C1 gene Odorant receptor. Indicus|evm.model.CM009495.1.544 Q9HD90 NDF4_HUMAN 91.239 0.993958 1 NEUROD4 - Neurogenic differentiation factor 4 - Homo sapiens (Human) - NEUROD4 gene Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity). Indicus|evm.model.CM009495.1.545 A2RU30 TESP1_HUMAN 80.614 0.861436 1.14971 TESPA1 - Protein TESPA1 - Homo sapiens (Human) - TESPA1 gene Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. Indicus|evm.model.CM009495.1.546 Q9HB63 NET4_HUMAN 91.242 0.99682 1.00159 NTN4 - Netrin-4 precursor - Homo sapiens (Human) - NTN4 gene May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. Indicus|evm.model.CM009495.1.547 P62321 RUXF_XENLA 100.000 0.674603 1.46512 snrpf - Small nuclear ribonucleoprotein F - Xenopus laevis (African clawed frog) - snrpf gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. Indicus|evm.model.CM009495.1.548 Q8CDN8 CCD38_MOUSE 74.047 0.951304 1.02131 Ccdc38 - Coiled-coil domain-containing protein 38 - Mus musculus (Mouse) - Ccdc38 gene centrosome Indicus|evm.model.CM009495.1.549 A5PJV3 HUTI_BOVIN 99.296 0.876289 1.1385 AMDHD1 - Probable imidazolonepropionase - Bos taurus (Bovine) - AMDHD1 gene imidazolonepropionase activity, histidine catabolic process Indicus|evm.model.CM009495.1.550 A7YWP4 HUTH_BOVIN 99.848 0.99696 1.00152 HAL - Histidine ammonia-lyase - Bos taurus (Bovine) - HAL gene ammonia-lyase activity, histidine ammonia-lyase activity, histidine catabolic process Indicus|evm.model.CM009495.1.551 Q3SZH7 LKHA4_BOVIN 99.836 0.996727 1 LTA4H - Leukotriene A-4 hydrolase - Bos taurus (Bovine) - LTA4H gene Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the proinflammatory mediator leukotriene B4 (LTB4). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its proinflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions. Indicus|evm.model.CM009495.1.552 P41970 ELK3_HUMAN 93.857 0.995037 0.990172 ELK3 - ETS domain-containing protein Elk-3 - Homo sapiens (Human) - ELK3 gene May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. Indicus|evm.model.CM009495.1.553 Q00537 CDK17_HUMAN 99.044 0.996183 1.00191 CDK17 - Cyclin-dependent kinase 17 - Homo sapiens (Human) - CDK17 gene May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Indicus|evm.model.CM009495.1.555 Q3B7M6 NEDD1_BOVIN 99.675 0.985554 0.945372 NEDD1 - Protein NEDD1 - Bos taurus (Bovine) - NEDD1 gene Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. Indicus|evm.model.CM009495.1.560 P42166 LAP2A_HUMAN 95.699 0.406593 0.65562 TMPO - Lamina-associated polypeptide 2, isoform alpha - Homo sapiens (Human) - TMPO gene May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1. Indicus|evm.model.CM009495.1.561 P12234 MPCP_BOVIN 96.961 0.994475 1 SLC25A3 - Phosphate carrier protein, mitochondrial precursor - Bos taurus (Bovine) - SLC25A3 gene Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP). Indicus|evm.model.CM009495.1.562 A2VE53 IKIP_BOVIN 100.000 0.988189 0.727794 IKBIP - Inhibitor of nuclear factor kappa-B kinase-interacting protein - Bos taurus (Bovine) - IKBIP gene Target of p53/TP53 with pro-apoptotic function. Indicus|evm.model.CM009495.1.563 Q5EAJ6 IKIP_RAT 80.161 0.986737 1.01072 Ikbip - Inhibitor of nuclear factor kappa-B kinase-interacting protein - Rattus norvegicus (Rat) - Ikbip gene Target of p53/TP53 with pro-apoptotic function. Indicus|evm.model.CM009495.1.564 O14727 APAF_HUMAN 90.392 0.9984 1.0016 APAF1 - Apoptotic protease-activating factor 1 - Homo sapiens (Human) - APAF1 gene Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. Indicus|evm.model.CM009495.1.565 Q9NZ56 FMN2_HUMAN 79.710 0.231293 0.170732 FMN2 - Formin-2 - Homo sapiens (Human) - FMN2 gene Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:22330775, PubMed:21730168). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:22330775, PubMed:21730168). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). Indicus|evm.model.CM009495.1.566 Q8BIZ1 ANS1B_MOUSE 98.681 0.932238 0.386815 Anks1b - Ankyrin repeat and sterile alpha motif domain-containing protein 1B - Mus musculus (Mouse) - Anks1b gene Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Indicus|evm.model.CM009495.1.567 Q7Z6G8 ANS1B_HUMAN 88.182 0.943966 0.185897 ANKS1B - Ankyrin repeat and sterile alpha motif domain-containing protein 1B - Homo sapiens (Human) - ANKS1B gene Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Indicus|evm.model.CM009495.1.570 Q9NV06 DCA13_HUMAN 51.482 0.981061 0.593258 DCAF13 - DDB1- and CUL4-associated factor 13 - Homo sapiens (Human) - DCAF13 gene Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Indicus|evm.model.CM009495.1.572 Q7Z6G8 ANS1B_HUMAN 98.421 0.887588 0.342147 ANKS1B - Ankyrin repeat and sterile alpha motif domain-containing protein 1B - Homo sapiens (Human) - ANKS1B gene Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Indicus|evm.model.CM009495.1.573 Q5T7W7 TSTD2_HUMAN 48.649 0.985401 0.265504 TSTD2 - Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 - Homo sapiens (Human) - TSTD2 gene Indicus|evm.model.CM009495.1.574 A0JNW5 UH1BL_HUMAN 90.604 0.991144 1.00273 UHRF1BP1L - UHRF1-binding protein 1-like - Homo sapiens (Human) - UHRF1BP1L gene cytosol, early endosome, GARP complex binding, protein homodimerization activity Indicus|evm.model.CM009495.1.575 Q9GZN1 ARP6_HUMAN 99.242 0.994962 1.00253 ACTR6 - Actin-related protein 6 - Homo sapiens (Human) - ACTR6 gene nucleus, Swr1 complex, nucleosome binding, histone exchange Indicus|evm.model.CM009495.1.576 Q6P3W7 SCYL2_HUMAN 92.896 0.997778 0.968784 SCYL2 - SCY1-like protein 2 - Homo sapiens (Human) - SCYL2 gene Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (PubMed:15809293, PubMed:16914521). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity). Indicus|evm.model.CM009495.1.577 Q8NDX2 VGLU3_HUMAN 93.888 0.996604 1 SLC17A8 - Vesicular glutamate transporter 3 - Homo sapiens (Human) - SLC17A8 gene Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Indicus|evm.model.CM009495.1.578 Q3SZL0 NR1H4_BOVIN 99.793 0.995859 1.00207 NR1H4 - Bile acid receptor - Bos taurus (Bovine) - NR1H4 gene Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity. In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). Activates transcription of the repressor MAFG (involved in regulation of BA synthesis). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine). In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression. The function also involves the coordinated induction of hepatic KLB/beta-klotho expression. Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA. Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly). Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance). Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element. Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase). Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes. Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance. Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier. Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells. Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2. Involved in the TLR9-mediated protective mechanism in intestinal inflammation. Plays an anti-inflammatory role in liver inflammation; proposed to inhibit proinflammatory (but not antiapoptotic) NF-kappa-B signaling. Indicus|evm.model.CM009495.1.579 Q86XJ1 GA2L3_HUMAN 82.853 0.945055 1.04899 GAS2L3 - GAS2-like protein 3 - Homo sapiens (Human) - GAS2L3 gene Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. Indicus|evm.model.CM009495.1.581 Q32M45 ANO4_HUMAN 98.639 0.997908 1.00105 ANO4 - Anoctamin-4 - Homo sapiens (Human) - ANO4 gene Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). Indicus|evm.model.CM009495.1.582 Q8N695 SC5A8_HUMAN 89.198 0.996732 1.00328 SLC5A8 - Sodium-coupled monocarboxylate transporter 1 - Homo sapiens (Human) - SLC5A8 gene Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Indicus|evm.model.CM009495.1.583 O75691 UTP20_HUMAN 89.274 0.99928 0.997846 UTP20 - Small subunit processome component 20 homolog - Homo sapiens (Human) - UTP20 gene Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. Indicus|evm.model.CM009495.1.584 Q2YDM1 ARL1_BOVIN 100.000 0.989011 1.00552 ARL1 - ADP-ribosylation factor-like protein 1 - Bos taurus (Bovine) - ARL1 gene GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). Indicus|evm.model.CM009495.1.585 P13182 CX6A1_BOVIN 96.330 0.981818 1.00917 COX6A1 - Cytochrome c oxidase subunit 6A1, mitochondrial precursor - Bos taurus (Bovine) - COX6A1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009495.1.586 Q1RML4 SPIC_BOVIN 100.000 0.991968 1.00403 SPIC - Transcription factor Spi-C - Bos taurus (Bovine) - SPIC gene Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). Indicus|evm.model.CM009495.1.587 Q1LZE6 CHPT1_BOVIN 99.178 0.229798 3.90148 CHPT1 - Cholinephosphotransferase 1 - Bos taurus (Bovine) - CHPT1 gene Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes. Indicus|evm.model.CM009495.1.588 Q3T0E2 SYCP3_BOVIN 99.087 0.810409 1.19556 SYCP3 - Synaptonemal complex protein 3 - Bos taurus (Bovine) - SYCP3 gene Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2. Indicus|evm.model.CM009495.1.589 Q3T906 GNPTA_HUMAN 88.655 0.896047 1.08758 GNPTAB - N-acetylglucosamine-1-phosphotransferase subunits alpha/beta precursor - Homo sapiens (Human) - GNPTAB gene Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. Indicus|evm.model.CM009495.1.590 Q9DC58 DRAM1_MOUSE 96.203 0.987448 1.0042 Dram1 - DNA damage-regulated autophagy modulator protein 1 - Mus musculus (Mouse) - Dram1 gene Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy (By similarity). Indicus|evm.model.CM009495.1.591 Q6AYL5 SF3B4_RAT 94.537 0.923077 1.07311 Sf3b4 - Splicing factor 3B subunit 4 - Rattus norvegicus (Rat) - Sf3b4 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Indicus|evm.model.CM009495.1.592 Q05B58 WASC3_BOVIN 99.485 0.989744 1.00515 WASHC3 - WASH complex subunit 3 - Bos taurus (Bovine) - WASHC3 gene Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Indicus|evm.model.CM009495.1.593 Q8NFH4 NUP37_HUMAN 86.810 0.99359 0.957055 NUP37 - Nucleoporin Nup37 - Homo sapiens (Human) - NUP37 gene Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. Indicus|evm.model.CM009495.1.594 F1MF21 PARI_BOVIN 85.052 0.996109 0.883162 PARPBP - PCNA-interacting partner - Bos taurus (Bovine) - PARPBP gene Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity). Indicus|evm.model.CM009495.1.595 P20382 MCH_HUMAN 91.515 0.987952 1.00606 PMCH - Pro-MCH precursor - Homo sapiens (Human) - PMCH gene MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation. Indicus|evm.model.CM009495.1.596 Q4R6V2 TCPE_MACFA 60.976 0.972569 0.74122 CCT5 - T-complex protein 1 subunit epsilon - Macaca fascicularis (Crab-eating macaque) - CCT5 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.CM009495.1.597 P07455 IGF1_BOVIN 100.000 0.987097 1.00649 IGF1 - Insulin-like growth factor I precursor - Bos taurus (Bovine) - IGF1 gene The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity). Indicus|evm.model.CM009495.1.599 Q2KIH7 PH4H_BOVIN 100.000 0.995575 1.00222 PAH - Phenylalanine-4-hydroxylase - Bos taurus (Bovine) - PAH gene Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Indicus|evm.model.CM009495.1.600 Q02067 ASCL1_MOUSE 97.661 0.772727 0.952381 Ascl1 - Achaete-scute homolog 1 - Mus musculus (Mouse) - Ascl1 gene Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways (PubMed:24243019). Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes (PubMed:20107439, PubMed:24243019, PubMed:27281220). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS (PubMed:8217843). Essential for the generation of olfactory and autonomic neurons (PubMed:8221886). Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation (PubMed:16020526, PubMed:17728344). Involved in the regulation of neuroendocrine cell development in the glandular stomach (PubMed:18173746). Indicus|evm.model.CM009495.1.602 Q8WWQ8 STAB2_HUMAN 84.392 0.999216 0.999608 STAB2 - Stabilin-2 precursor - Homo sapiens (Human) - STAB2 gene Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS. Indicus|evm.model.CM009495.1.603 Q86UY8 NT5D3_HUMAN 95.437 0.959707 0.99635 NT5DC3 - 5'-nucleotidase domain-containing protein 3 - Homo sapiens (Human) - NT5DC3 gene receptor complex, 5'-nucleotidase activity Indicus|evm.model.CM009495.1.604 Q6P2S7 TTC41_HUMAN 61.111 0.964072 0.126707 TTC41P - Putative tetratricopeptide repeat protein 41 - Homo sapiens (Human) - TTC41P gene Indicus|evm.model.CM009495.1.605 Q6P2S7 TTC41_HUMAN 75.218 0.461789 0.933232 TTC41P - Putative tetratricopeptide repeat protein 41 - Homo sapiens (Human) - TTC41P gene Indicus|evm.model.CM009495.1.606 Q95M18 ENPL_BOVIN 100.000 0.997516 1.00124 HSP90B1 - Endoplasmin precursor - Bos taurus (Bovine) - HSP90B1 gene Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity). Indicus|evm.model.CM009495.1.607 Q69YU5 BWNIN_HUMAN 84.615 0.587156 1.53521 BRAWNIN - Protein BRAWNIN - Homo sapiens (Human) - BRAWNIN gene Essential for mitochondrial respiratory chain complex III (CIII) assembly and stability. Indicus|evm.model.CM009495.1.608 Q13569 TDG_HUMAN 92.118 0.883516 1.10976 TDG - G/T mismatch-specific thymine DNA glycosylase - Homo sapiens (Human) - TDG gene DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. Indicus|evm.model.CM009495.1.609 Q2HJ96 GL8D2_BOVIN 100.000 0.994302 1.00286 GLT8D2 - Glycosyltransferase 8 domain-containing protein 2 - Bos taurus (Bovine) - GLT8D2 gene Golgi apparatus Indicus|evm.model.CM009495.1.610 Q9Y5Z7 HCFC2_HUMAN 94.823 0.997478 1.00126 HCFC2 - Host cell factor 2 - Homo sapiens (Human) - HCFC2 gene cytoplasm, cytosol, histone methyltransferase complex, nuclear body, nucleoplasm, nucleus, plasma membrane, transcription coactivator activity, chromatin remodeling, negative regulation of transcription by RNA polymerase II Indicus|evm.model.CM009495.1.611 Q32KW0 NFYB_BOVIN 100.000 0.990385 1.00483 NFYB - Nuclear transcription factor Y subunit beta - Bos taurus (Bovine) - NFYB gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors (By similarity). Indicus|evm.model.CM009495.1.612 A6QPC8 EID3_BOVIN 99.705 0.370208 2.40897 EID3 - EP300-interacting inhibitor of differentiation 3 - Bos taurus (Bovine) - EID3 gene Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). Indicus|evm.model.CM009495.1.613 Q9NPF2 CHSTB_HUMAN 99.038 0.99361 0.889205 CHST11 - Carbohydrate sulfotransferase 11 - Homo sapiens (Human) - CHST11 gene Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. Indicus|evm.model.CM009495.1.614 Q4R335 S41A2_MACFA 94.939 0.996516 1.00175 SLC41A2 - Solute carrier family 41 member 2 - Macaca fascicularis (Crab-eating macaque) - SLC41A2 gene Acts as a plasma-membrane magnesium transporter. Indicus|evm.model.CM009495.1.616 Q2TBJ0 CL045_BOVIN 98.438 0.989637 1.00521 NOPCHAP1 - NOP protein chaperone 1 - Bos taurus (Bovine) - NOPCHAP1 gene Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2. Indicus|evm.model.CM009495.1.617 Q3SY69 AL1L2_HUMAN 94.908 0.997835 1.00108 ALDH1L2 - Mitochondrial 10-formyltetrahydrofolate dehydrogenase - Homo sapiens (Human) - ALDH1L2 gene extracellular exosome, mitochondrial matrix, mitochondrion, nucleoplasm, aldehyde dehydrogenase (NAD+) activity, formyltetrahydrofolate dehydrogenase activity, folic acid metabolic process Indicus|evm.model.CM009495.1.618 Q2M389 WASC4_HUMAN 98.806 0.998296 1.00085 WASHC4 - WASH complex subunit 4 - Homo sapiens (Human) - WASHC4 gene Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Indicus|evm.model.CM009495.1.619 Q8NEU8 DP13B_HUMAN 93.373 0.996983 0.998494 APPL2 - DCC-interacting protein 13-beta - Homo sapiens (Human) - APPL2 gene Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). Indicus|evm.model.CM009495.1.621 O60285 NUAK1_HUMAN 94.127 0.996983 1.00303 NUAK1 - NUAK family SNF1-like kinase 1 - Homo sapiens (Human) - NUAK1 gene Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). Indicus|evm.model.CM009495.1.622 Q07065 CKAP4_HUMAN 79.236 0.99661 0.980066 CKAP4 - Cytoskeleton-associated protein 4 - Homo sapiens (Human) - CKAP4 gene Mediates the anchoring of the endoplasmic reticulum to microtubules. Indicus|evm.model.CM009495.1.623 A7Z033 T11L2_BOVIN 100.000 0.996154 1.00193 TCP11L2 - T-complex protein 11-like protein 2 - Bos taurus (Bovine) - TCP11L2 gene signal transduction Indicus|evm.model.CM009495.1.624 Q9NW08 RPC2_HUMAN 96.911 0.9982 0.980583 POLR3B - DNA-directed RNA polymerase III subunit RPC2 - Homo sapiens (Human) - POLR3B gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Indicus|evm.model.CM009495.1.625 Q33E94 RFX4_HUMAN 98.611 0.997226 0.980952 RFX4 - Transcription factor RFX4 - Homo sapiens (Human) - RFX4 gene Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development. Indicus|evm.model.CM009495.1.626 Q9NVN3 RIC8B_HUMAN 91.607 0.996435 1.07885 RIC8B - Synembryn-B - Homo sapiens (Human) - RIC8B gene Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction. Indicus|evm.model.CM009495.1.627 Q3SYV1 TM263_BOVIN 100.000 0.982906 1.00862 TMEM263 - Transmembrane protein 263 - Bos taurus (Bovine) - TMEM263 gene Indicus|evm.model.CM009495.1.628 Q5R6G1 MTEF2_PONAB 88.312 0.436364 2.28571 MTERF2 - Transcription termination factor 2, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - MTERF2 gene Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species. Indicus|evm.model.CM009495.1.629 P68002 VDAC2_BOVIN 98.299 0.864307 1.15306 VDAC2 - Voltage-dependent anion-selective channel protein 2 - Bos taurus (Bovine) - VDAC2 gene Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity). Binding of ceramide promotes the Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity). Indicus|evm.model.CM009495.1.630 A6QL63 BTBDB_HUMAN 97.017 0.99843 0.576993 BTBD11 - Ankyrin repeat and BTB/POZ domain-containing protein BTBD11 - Homo sapiens (Human) - BTBD11 gene SMAD protein signal transduction Indicus|evm.model.CM009495.1.631 Q2HJ56 PWP1_BOVIN 100.000 0.996008 1.002 PWP1 - Periodic tryptophan protein 1 homolog - Bos taurus (Bovine) - PWP1 gene Chromatin-associated factor that regulates transcription (By similarity). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (By similarity). Regulates the epigenetic status of rDNA (By similarity). Indicus|evm.model.CM009495.1.632 Q9UKN5 PRDM4_HUMAN 97.129 0.997506 1.00125 PRDM4 - PR domain zinc finger protein 4 - Homo sapiens (Human) - PRDM4 gene May function as a transcription factor involved in cell differentiation. Indicus|evm.model.CM009495.1.633 Q9JJR7 ASCL3_MOUSE 70.769 0.378698 0.971264 Ascl3 - Achaete-scute homolog 3 - Mus musculus (Mouse) - Ascl3 gene Transcriptional repressor. Inhibits myogenesis. Indicus|evm.model.CM009495.1.634 Q5E9T9 RTCB_BOVIN 100.000 0.996047 1.00198 RTCB - RNA-splicing ligase RtcB homolog - Bos taurus (Bovine) - RTCB gene Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Indicus|evm.model.CM009495.1.635 Q8NFQ6 BPIFC_HUMAN 82.869 0.932 0.986193 BPIFC - BPI fold-containing family C protein precursor - Homo sapiens (Human) - BPIFC gene extracellular space, lipopolysaccharide binding, phospholipid binding Indicus|evm.model.CM009495.1.636 Q2T9S7 FBX7_BOVIN 99.425 0.996176 1.00192 FBXO7 - F-box only protein 7 - Bos taurus (Bovine) - FBXO7 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity). Indicus|evm.model.CM009495.1.637 O14994 SYN3_HUMAN 94.138 0.996546 0.998276 SYN3 - Synapsin-3 - Homo sapiens (Human) - SYN3 gene May be involved in the regulation of neurotransmitter release and synaptogenesis. Indicus|evm.model.CM009495.1.638 Q2KIX7 HP251_BOVIN 99.528 0.99061 1.00472 Protein HP-25 homolog 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.639 Q2KIU3 HP252_BOVIN 100.000 0.990741 1.00465 Protein HP-25 homolog 2 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.640 Q2KIT0 HP20_BOVIN 100.000 0.989583 1.00524 Protein HP-20 homolog precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.641 O95461 LARG1_HUMAN 97.884 0.997358 1.00132 LARGE1 - LARGE xylosyl- and glucuronyltransferase 1 - Homo sapiens (Human) - LARGE1 gene Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699). Indicus|evm.model.CM009495.1.643 Q6PGH4 F222A_MOUSE 98.305 0.794521 0.161148 Fam222a - Protein FAM222A - Mus musculus (Mouse) - Fam222a gene Indicus|evm.model.CM009495.1.644 Q2M1V0 ISX_HUMAN 68.235 0.913514 0.755102 ISX - Intestine-specific homeobox - Homo sapiens (Human) - ISX gene Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine (By similarity). Indicus|evm.model.CM009495.1.645 Q9UGU5 HMGX4_HUMAN 93.688 0.996683 1.00333 HMGXB4 - HMG domain-containing protein 4 - Homo sapiens (Human) - HMGXB4 gene Negatively regulates Wnt/beta-catenin signaling during development. Indicus|evm.model.CM009495.1.646 O60784 TOM1_HUMAN 92.480 0.995943 1.00203 TOM1 - Target of Myb protein 1 - Homo sapiens (Human) - TOM1 gene May be involved in intracellular trafficking. Probable association with membranes. Indicus|evm.model.CM009495.1.647 Q5E9F2 HMOX1_BOVIN 100.000 0.993103 1.00346 HMOX1 - Heme oxygenase 1 - Bos taurus (Bovine) - HMOX1 gene Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. Indicus|evm.model.CM009495.1.648 Q0V8B7 MCM5_BOVIN 99.864 0.997279 1.00136 MCM5 - DNA replication licensing factor MCM5 - Bos taurus (Bovine) - MCM5 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Indicus|evm.model.CM009495.1.649 Q96D21 RHES_HUMAN 98.496 0.765896 1.30075 RASD2 - GTP-binding protein Rhes precursor - Homo sapiens (Human) - RASD2 gene GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. Indicus|evm.model.CM009495.1.650 P02192 MYG_BOVIN 100.000 0.987097 1.00649 MB - Myoglobin - Bos taurus (Bovine) - MB gene Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Indicus|evm.model.CM009495.1.651 Q9BWW8 APOL6_HUMAN 55.987 0.871429 1.02041 APOL6 - Apolipoprotein L6 - Homo sapiens (Human) - APOL6 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Indicus|evm.model.CM009495.1.652 A6QPR6 RFOX2_BOVIN 99.482 0.992268 0.984772 RBFOX2 - RNA binding protein fox-1 homolog 2 - Bos taurus (Bovine) - RBFOX2 gene RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity). Indicus|evm.model.CM009495.1.653 P35579 MYH9_HUMAN 47.126 0.206989 0.189796 MYH9 - Myosin-9 - Homo sapiens (Human) - MYH9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). Indicus|evm.model.CM009495.1.656 Q8VDD5 MYH9_MOUSE 68.831 0.216524 0.179082 Myh9 - Myosin-9 - Mus musculus (Mouse) - Myh9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (PubMed:19401332). Required for cortical actin clearance prior to oocyte exocytosis (PubMed:31118423). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Indicus|evm.model.CM009495.1.658 P14105 MYH9_CHICK 57.317 0.457143 0.0893313 MYH9 - Myosin-9 - Gallus gallus (Chicken) - MYH9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Indicus|evm.model.CM009495.1.660 P14105 MYH9_CHICK 80.000 0.153543 0.129658 MYH9 - Myosin-9 - Gallus gallus (Chicken) - MYH9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Indicus|evm.model.CM009495.1.663 O95236 APOL3_HUMAN 43.713 0.959627 0.800995 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Indicus|evm.model.CM009495.1.664 O95236 APOL3_HUMAN 57.143 0.584112 0.532338 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Indicus|evm.model.CM009495.1.665 O95236 APOL3_HUMAN 45.723 0.954407 0.818408 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Indicus|evm.model.CM009495.1.666 O95236 APOL3_HUMAN 45.392 0.964029 0.691542 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Indicus|evm.model.CM009495.1.668 O95236 APOL3_HUMAN 52.308 0.576577 0.276119 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Indicus|evm.model.CM009495.1.669 Q9BWW8 APOL6_HUMAN 47.036 0.681081 1.07872 APOL6 - Apolipoprotein L6 - Homo sapiens (Human) - APOL6 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Indicus|evm.model.CM009495.1.670 Q258K2 MYH9_CANLF 97.592 0.827743 1.12551 MYH9 - Myosin-9 - Canis lupus familiaris (Dog) - MYH9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Indicus|evm.model.CM009495.1.671 Q95108 THIOM_BOVIN 100.000 0.988024 1.00602 TXN2 - Thioredoxin, mitochondrial precursor - Bos taurus (Bovine) - TXN2 gene Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity. Indicus|evm.model.CM009495.1.672 Q8IWF2 FXRD2_HUMAN 82.489 0.997106 1.01023 FOXRED2 - FAD-dependent oxidoreductase domain-containing protein 2 precursor - Homo sapiens (Human) - FOXRED2 gene Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Indicus|evm.model.CM009495.1.673 Q3T122 EIF3D_BOVIN 100.000 0.996357 1.00182 EIF3D - Eukaryotic translation initiation factor 3 subunit D - Bos taurus (Bovine) - EIF3D gene mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. Indicus|evm.model.CM009495.1.674 Q9Y698 CCG2_HUMAN 99.608 0.980695 0.801858 CACNG2 - Voltage-dependent calcium channel gamma-2 subunit - Homo sapiens (Human) - CACNG2 gene Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Indicus|evm.model.CM009495.1.675 Q0VCN3 IFT27_BOVIN 89.247 0.988024 0.897849 IFT27 - Intraflagellar transport protein 27 homolog - Bos taurus (Bovine) - IFT27 gene Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation. Indicus|evm.model.CM009495.1.677 Q0VCG3 PRVA_BOVIN 100.000 0.981982 1.00909 PVALB - Parvalbumin alpha - Bos taurus (Bovine) - PVALB gene In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). Indicus|evm.model.CM009495.1.678 Q15080 NCF4_HUMAN 89.676 0.994118 1.00295 NCF4 - Neutrophil cytosol factor 4 - Homo sapiens (Human) - NCF4 gene Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. Indicus|evm.model.CM009495.1.679 P32927 IL3RB_HUMAN 66.073 0.997755 0.993311 CSF2RB - Cytokine receptor common subunit beta precursor - Homo sapiens (Human) - CSF2RB gene High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. Indicus|evm.model.CM009495.1.680 P00586 THTR_BOVIN 100.000 0.351741 2.80471 TST - Thiosulfate sulfurtransferase - Bos taurus (Bovine) - TST gene Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Formation of iron-sulfur complexes and cyanide detoxification. Binds molecular oxygen and sulfur. Indicus|evm.model.CM009495.1.681 P25325 THTM_HUMAN 88.889 0.888889 1.12121 MPST - 3-mercaptopyruvate sulfurtransferase - Homo sapiens (Human) - MPST gene Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. Indicus|evm.model.CM009495.1.682 Q8N5Z5 KCD17_HUMAN 89.823 0.589041 1.13707 KCTD17 - BTB/POZ domain-containing protein KCTD17 - Homo sapiens (Human) - KCTD17 gene Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243). Indicus|evm.model.CM009495.1.683 Q8IU80 TMPS6_HUMAN 89.776 0.997503 0.98767 TMPRSS6 - Transmembrane protease serine 6 - Homo sapiens (Human) - TMPRSS6 gene Membrane-bound serine protease (PubMed:18976966, PubMed:20518742, PubMed:25156943, PubMed:25588876). Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:25156943, PubMed:18408718, PubMed:18976966). Indicus|evm.model.CM009495.1.684 Q38J85 IL2RB_MACFA 62.970 0.529471 1.8167 IL2RB - Interleukin-2 receptor subunit beta precursor - Macaca fascicularis (Crab-eating macaque) - IL2RB gene Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Indicus|evm.model.CM009495.1.685 Q3T1I2 C1QT6_RAT 73.507 0.988889 1.02662 C1qtnf6 - Complement C1q tumor necrosis factor-related protein 6 precursor - Rattus norvegicus (Rat) - C1qtnf6 gene extracellular space, protein-containing complex, identical protein binding Indicus|evm.model.CM009495.1.686 P61294 RAB6B_MOUSE 73.770 0.869565 0.331731 Rab6b - Ras-related protein Rab-6B - Mus musculus (Mouse) - Rab6b gene Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity). Indicus|evm.model.CM009495.1.687 P32745 SSR3_HUMAN 86.967 0.995272 1.01196 SSTR3 - Somatostatin receptor type 3 - Homo sapiens (Human) - SSTR3 gene Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. Indicus|evm.model.CM009495.1.688 Q9TU25 RAC2_BOVIN 100.000 0.989637 1.00521 RAC2 - Ras-related C3 botulinum toxin substrate 2 precursor - Bos taurus (Bovine) - RAC2 gene Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). Indicus|evm.model.CM009495.1.689 Q9UIA0 CYH4_HUMAN 94.133 0.951338 1.04315 CYTH4 - Cytohesin-4 - Homo sapiens (Human) - CYTH4 gene Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. Indicus|evm.model.CM009495.1.690 Q5R3F8 PPR29_HUMAN 94.539 0.997576 1.0061 ELFN2 - Protein phosphatase 1 regulatory subunit 29 precursor - Homo sapiens (Human) - ELFN2 gene Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Indicus|evm.model.CM009495.1.691 O00587 MFNG_HUMAN 87.812 0.993769 1 MFNG - Beta-1,3-N-acetylglucosaminyltransferase manic fringe - Homo sapiens (Human) - MFNG gene Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Indicus|evm.model.CM009495.1.692 Q9BWT7 CAR10_HUMAN 92.163 0.972763 0.996124 CARD10 - Caspase recruitment domain-containing protein 10 - Homo sapiens (Human) - CARD10 gene Activates NF-kappa-B via BCL10 and IKK. Indicus|evm.model.CM009495.1.693 Q3LFD5 UBP41_HUMAN 76.471 0.947205 0.899441 USP41 - Putative ubiquitin carboxyl-terminal hydrolase 41 - Homo sapiens (Human) - USP41 gene May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Indicus|evm.model.CM009495.1.694 Q5BKT4 AG10A_HUMAN 92.616 0.987474 1.01268 ALG10 - Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase - Homo sapiens (Human) - ALG10 gene Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. Indicus|evm.model.CM009495.1.695 Q6XYQ8 SYT10_HUMAN 86.538 0.708333 0.137667 SYT10 - Synaptotagmin-10 - Homo sapiens (Human) - SYT10 gene Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Indicus|evm.model.CM009495.1.697 Q5RCK6 SYT10_PONAB 96.364 0.891599 0.705545 SYT10 - Synaptotagmin-10 - Pongo abelii (Sumatran orangutan) - SYT10 gene Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Indicus|evm.model.CM009495.1.698 Q99959 PKP2_HUMAN 82.197 0.952941 0.964813 PKP2 - Plakophilin-2 - Homo sapiens (Human) - PKP2 gene May play a role in junctional plaques. Indicus|evm.model.CM009495.1.699 Q9Y2Z4 SYYM_HUMAN 89.121 0.995825 1.00419 YARS2 - Tyrosine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - YARS2 gene Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Indicus|evm.model.CM009495.1.700 O00429 DNM1L_HUMAN 99.321 0.997286 1.00136 DNM1L - Dynamin-1-like protein - Homo sapiens (Human) - DNM1L gene Functions in mitochondrial and peroxisomal division (PubMed:9570752, PubMed:9786947, PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17553808, PubMed:17460227, PubMed:18695047, PubMed:18838687, PubMed:19638400, PubMed:19411255, PubMed:19342591, PubMed:23921378, PubMed:23283981, PubMed:23530241, PubMed:29478834, PubMed:32484300, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23921378, PubMed:23283981, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:9570752, PubMed:20688057, PubMed:23792689). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). Indicus|evm.model.CM009495.1.701 Q96M96 FGD4_HUMAN 91.081 0.808324 1.19191 FGD4 - FYVE, RhoGEF and PH domain-containing protein 4 - Homo sapiens (Human) - FGD4 gene Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). Indicus|evm.model.CM009495.1.702 Q96G01 BICD1_HUMAN 98.250 0.979381 0.895385 BICD1 - Protein bicaudal D homolog 1 - Homo sapiens (Human) - BICD1 gene Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. Indicus|evm.model.CM009495.1.703 Q9HCM1 RESF1_HUMAN 61.495 0.998852 0.997138 RESF1 - Retroelement silencing factor 1 - Homo sapiens (Human) - RESF1 gene Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. Indicus|evm.model.CM009495.1.705 Q32L08 AMN1_BOVIN 99.612 0.992278 1.00388 AMN1 - Protein AMN1 homolog - Bos taurus (Bovine) - AMN1 gene Indicus|evm.model.CM009495.1.706 Q8IXQ9 ETKMT_HUMAN 81.955 0.992509 1.01908 ETFBKMT - Electron transfer flavoprotein beta subunit lysine methyltransferase precursor - Homo sapiens (Human) - ETFBKMT gene Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781). Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781). Indicus|evm.model.CM009495.1.707 Q6ZUT9 DEN5B_HUMAN 97.174 0.998431 1.00078 DENND5B - DENN domain-containing protein 5B - Homo sapiens (Human) - DENND5B gene Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Indicus|evm.model.CM009495.1.708 Q9NP50 SHCAF_HUMAN 100.000 0.990991 1.00452 SINHCAF - SIN3-HDAC complex-associated factor - Homo sapiens (Human) - SINHCAF gene Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity). Indicus|evm.model.CM009495.1.709 Q6IMN6 CAPR2_HUMAN 92.157 0.989805 0.957409 CAPRIN2 - Caprin-2 - Homo sapiens (Human) - CAPRIN2 gene Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112). Indicus|evm.model.CM009495.1.710 O15397 IPO8_HUMAN 96.914 0.998073 1.00096 IPO8 - Importin-8 - Homo sapiens (Human) - IPO8 gene Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. Indicus|evm.model.CM009495.1.712 Q3UV71 TMTC1_MOUSE 86.123 0.916016 1.08705 Tmtc1 - Protein O-mannosyl-transferase TMTC1 - Mus musculus (Mouse) - Tmtc1 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Indicus|evm.model.CM009495.1.713 Q7RTY7 OVCH1_HUMAN 69.718 0.215046 1.16049 OVCH1 - Ovochymase-1 precursor - Homo sapiens (Human) - OVCH1 gene Indicus|evm.model.CM009495.1.714 Q4R5C3 ERGI2_MACFA 95.491 0.994709 1.00265 ERGIC2 - Endoplasmic reticulum-Golgi intermediate compartment protein 2 - Macaca fascicularis (Crab-eating macaque) - ERGIC2 gene Possible role in transport between endoplasmic reticulum and Golgi. Indicus|evm.model.CM009495.1.715 Q0P5J1 FACR2_BOVIN 100.000 0.996124 1.00194 FAR2 - Fatty acyl-CoA reductase 2 - Bos taurus (Bovine) - FAR2 gene Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates. Indicus|evm.model.CM009495.1.716 P62912 RL32_RAT 83.019 0.525253 0.733333 Rpl32 - 60S ribosomal protein L32 - Rattus norvegicus (Rat) - Rpl32 gene cytosolic large ribosomal subunit, polysomal ribosome, cellular response to dexamethasone stimulus, cytoplasmic translation, liver regeneration Indicus|evm.model.CM009495.1.717 Q7Z6B0 CCD91_HUMAN 92.986 0.995485 1.00454 CCDC91 - Coiled-coil domain-containing protein 91 - Homo sapiens (Human) - CCDC91 gene Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. Indicus|evm.model.CM009495.1.719 P58073 PTHR_BOVIN 100.000 0.988636 0.99435 PTHLH - Parathyroid hormone-related protein precursor - Bos taurus (Bovine) - PTHLH gene Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Indicus|evm.model.CM009495.1.720 P13184 CX7A2_BOVIN 93.976 0.97619 1.01205 COX7A2 - Cytochrome c oxidase subunit 7A2, mitochondrial precursor - Bos taurus (Bovine) - COX7A2 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009495.1.721 Q9P2K6 KLH42_HUMAN 95.455 0.996055 1.00396 KLHL42 - Kelch-like protein 42 - Homo sapiens (Human) - KLHL42 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis. Indicus|evm.model.CM009495.1.722 A6NHS7 MANS4_HUMAN 78.049 0.984894 0.973529 MANSC4 - MANSC domain-containing protein 4 precursor - Homo sapiens (Human) - MANSC4 gene Indicus|evm.model.CM009495.1.723 Q2YDF6 RT35_BOVIN 99.691 0.990798 1.00308 MRPS35 - 28S ribosomal protein S35, mitochondrial precursor - Bos taurus (Bovine) - MRPS35 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009495.1.724 Q6BDI9 REP15_HUMAN 79.661 0.991416 0.987288 REP15 - Rab15 effector protein - Homo sapiens (Human) - REP15 gene Regulates transferrin receptor recycling from the endocytic recycling compartment. Indicus|evm.model.CM009495.1.725 Q8C8U0 LIPB1_MOUSE 87.827 0.997984 1.02374 Ppfibp1 - Liprin-beta-1 - Mus musculus (Mouse) - Ppfibp1 gene May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity). Indicus|evm.model.CM009495.1.726 Q32LI3 CL071_BOVIN 98.452 0.889503 1.04323 Uncharacterized protein C12orf71 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.727 P62828 RAN_RAT 82.938 0.875622 0.930556 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Indicus|evm.model.CM009495.1.728 A6NFE2 SMCO2_HUMAN 55.000 0.99373 0.930029 SMCO2 - Single-pass membrane and coiled-coil domain-containing protein 2 - Homo sapiens (Human) - SMCO2 gene Indicus|evm.model.CM009495.1.729 Q8WYA1 BMAL2_HUMAN 85.317 0.996032 0.792453 ARNTL2 - Aryl hydrocarbon receptor nuclear translocator-like protein 2 - Homo sapiens (Human) - ARNTL2 gene Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. Indicus|evm.model.CM009495.1.731 Q9Y2H1 ST38L_HUMAN 99.138 0.995699 1.00216 STK38L - Serine/threonine-protein kinase 38-like - Homo sapiens (Human) - STK38L gene Involved in the regulation of structural processes in differentiating and mature neuronal cells. Indicus|evm.model.CM009495.1.732 Q2TBU8 MED21_BOVIN 100.000 0.986207 1.00694 MED21 - Mediator of RNA polymerase II transcription subunit 21 - Bos taurus (Bovine) - MED21 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009495.1.733 Q9NS93 TM7S3_HUMAN 82.632 0.996497 1.00175 TM7SF3 - Transmembrane 7 superfamily member 3 precursor - Homo sapiens (Human) - TM7SF3 gene Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623). Indicus|evm.model.CM009495.1.734 Q9NVK5 FGOP2_HUMAN 97.628 0.980545 1.01581 FGFR1OP2 - FGFR1 oncogene partner 2 - Homo sapiens (Human) - FGFR1OP2 gene May be involved in wound healing pathway. Indicus|evm.model.CM009495.1.735 Q9NVM9 INT13_HUMAN 99.150 0.997171 1.00142 INTS13 - Integrator complex subunit 13 - Homo sapiens (Human) - INTS13 gene Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267). Indicus|evm.model.CM009495.1.736 P62752 RL23A_RAT 66.667 0.77305 0.903846 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009495.1.738 Q8WN96 ITPR2_BOVIN 90.716 0.944444 0.386524 ITPR2 - Inositol 1,4,5-trisphosphate receptor type 2 - Bos taurus (Bovine) - ITPR2 gene Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium (PubMed:11584008). This release is regulated by cAMP both dependently and independently of PKA (By similarity). Indicus|evm.model.CM009495.1.739 Q14714 SSPN_HUMAN 90.000 0.985816 0.580247 SSPN - Sarcospan - Homo sapiens (Human) - SSPN gene Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC. Indicus|evm.model.CM009495.1.740 Q14714 SSPN_HUMAN 86.441 0.411348 0.580247 SSPN - Sarcospan - Homo sapiens (Human) - SSPN gene Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC. Indicus|evm.model.CM009495.1.741 Q9C0J9 BHE41_HUMAN 95.122 0.931559 0.545643 BHLHE41 - Class E basic helix-loop-helix protein 41 - Homo sapiens (Human) - BHLHE41 gene Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:11278948, PubMed:14672706, PubMed:15193144, PubMed:15560782, PubMed:18411297, PubMed:19786558, PubMed:25083013). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:25083013). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity). Indicus|evm.model.CM009495.1.742 Q8NHQ8 RASF8_HUMAN 98.091 0.995238 1.00239 RASSF8 - Ras association domain-containing protein 8 - Homo sapiens (Human) - RASSF8 gene Indicus|evm.model.CM009495.1.743 Q96MW7 TIGD1_HUMAN 44.780 0.993506 0.521151 TIGD1 - Tigger transposable element-derived protein 1 - Homo sapiens (Human) - TIGD1 gene nucleus, DNA binding Indicus|evm.model.CM009495.1.745 Q4R899 LMTD1_MACFA 54.177 0.904762 0.935644 LMNTD1 - Lamin tail domain-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - LMNTD1 gene Indicus|evm.model.CM009495.1.746 P79800 RASK_MELGA 99.468 0.989418 1.00532 KRAS - GTPase KRas precursor - Meleagris gallopavo (Wild turkey) - KRAS gene Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. May play a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs). Indicus|evm.model.CM009495.1.747 Q0VCR0 ETFR1_BOVIN 100.000 0.977528 1.01136 ETFRF1 - Electron transfer flavoprotein regulatory factor 1 - Bos taurus (Bovine) - ETFRF1 gene Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). Indicus|evm.model.CM009495.1.748 Q29RU8 CASC1_BOVIN 100.000 0.572438 0.791608 DNAI7 - Dynein axonemal intermediate chain 7 - Bos taurus (Bovine) - DNAI7 gene Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function. May act as a cell cycle regulator. Indicus|evm.model.CM009495.1.749 Q12912 IRAG2_HUMAN 80.541 0.382108 2.5982 IRAG2 - Inositol 1,4,5-triphosphate receptor associated 2 - Homo sapiens (Human) - IRAG2 gene Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Indicus|evm.model.CM009495.1.750 Q9GKM4 BCAT1_SHEEP 98.177 0.9599 1.03636 BCAT1 - Branched-chain-amino-acid aminotransferase, cytosolic - Ovis aries (Sheep) - BCAT1 gene Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Indicus|evm.model.CM009495.1.751 P35711 SOX5_HUMAN 94.758 0.997257 0.955439 SOX5 - Transcription factor SOX-5 - Homo sapiens (Human) - SOX5 gene Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. Indicus|evm.model.CM009495.1.753 P47914 RL29_HUMAN 60.526 0.596774 0.779874 RPL29 - 60S ribosomal protein L29 - Homo sapiens (Human) - RPL29 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009495.1.754 Q9HBU6 EKI1_HUMAN 97.521 0.994505 0.80531 ETNK1 - Ethanolamine kinase 1 - Homo sapiens (Human) - ETNK1 gene Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. Indicus|evm.model.CM009495.1.755 Q86YS7 C2CD5_HUMAN 93.245 0.998099 1.052 C2CD5 - C2 domain-containing protein 5 - Homo sapiens (Human) - C2CD5 gene Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. Indicus|evm.model.CM009495.1.756 Q6ZXD2 SIA8A_BOVIN 99.719 0.994398 1.00281 ST8SIA1 - Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase - Bos taurus (Bovine) - ST8SIA1 gene Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid (By similarity). Can catalyze the addition of a second alpha-2,8- sialic acid to GD3 to form GT3 (By similarity). Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (By similarity). Indicus|evm.model.CM009495.1.758 Q3SZM5 NEUA_BOVIN 93.349 0.995305 0.981567 CMAS - N-acylneuraminate cytidylyltransferase - Bos taurus (Bovine) - CMAS gene Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (By similarity). Indicus|evm.model.CM009495.1.759 O60706 ABCC9_HUMAN 96.893 0.996129 1.00065 ABCC9 - ATP-binding cassette sub-family C member 9 - Homo sapiens (Human) - ABCC9 gene Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Indicus|evm.model.CM009495.1.760 Q15842 KCNJ8_HUMAN 99.764 0.995294 1.00236 KCNJ8 - ATP-sensitive inward rectifier potassium channel 8 - Homo sapiens (Human) - KCNJ8 gene This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). Indicus|evm.model.CM009495.1.761 Q5E9B1 LDHB_BOVIN 100.000 0.99403 1.00299 LDHB - L-lactate dehydrogenase B chain - Bos taurus (Bovine) - LDHB gene L-lactate dehydrogenase activity Indicus|evm.model.CM009495.1.762 P54840 GYS2_HUMAN 93.314 0.997155 1 GYS2 - Glycogen [starch] synthase, liver - Homo sapiens (Human) - GYS2 gene Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Indicus|evm.model.CM009495.1.763 Q0VC44 SPXN_BOVIN 100.000 0.982906 1.00862 SPX - Spexin precursor - Bos taurus (Bovine) - SPX gene Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). Indicus|evm.model.CM009495.1.764 Q9Y3E0 GOT1B_HUMAN 96.296 0.985294 0.985507 GOLT1B - Vesicle transport protein GOT1B - Homo sapiens (Human) - GOLT1B gene May be involved in fusion of ER-derived transport vesicles with the Golgi complex. Indicus|evm.model.CM009495.1.765 P46063 RECQ1_HUMAN 90.601 0.829706 1.20339 RECQL - ATP-dependent DNA helicase Q1 - Homo sapiens (Human) - RECQL gene DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Indicus|evm.model.CM009495.1.766 A7YVH9 PYRD1_BOVIN 100.000 0.996024 1.00199 PYROXD1 - Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 - Bos taurus (Bovine) - PYROXD1 gene Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity (By similarity). Indicus|evm.model.CM009495.1.767 P46721 SO1A2_HUMAN 82.239 0.997001 0.995522 SLCO1A2 - Solute carrier organic anion transporter family member 1A2 - Homo sapiens (Human) - SLCO1A2 gene Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin. Indicus|evm.model.CM009495.1.768 Q9NPD5 SO1B3_HUMAN 71.280 0.972464 0.982906 SLCO1B3 - Solute carrier organic anion transporter family member 1B3 - Homo sapiens (Human) - SLCO1B3 gene Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. Indicus|evm.model.CM009495.1.769 Q9GMU6 SO1C1_MACFA 87.413 0.638806 1.11296 SLCO1C1 - Solute carrier organic anion transporter family member 1C1 - Macaca fascicularis (Crab-eating macaque) - SLCO1C1 gene Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), estradiol-17-beta-glucuronide, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain (By similarity). Indicus|evm.model.CM009495.1.770 Q14432 PDE3A_HUMAN 87.029 0.998165 0.955302 PDE3A - cGMP-inhibited 3',5'-cyclic phosphodiesterase A - Homo sapiens (Human) - PDE3A gene Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Indicus|evm.model.CM009495.1.771 A4FV57 AEBP2_BOVIN 99.805 0.996101 1.00391 AEBP2 - Zinc finger protein AEBP2 - Bos taurus (Bovine) - AEBP2 gene Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex. Indicus|evm.model.CM009495.1.772 Q9HAU0 PKHA5_HUMAN 81.761 0.253002 1.11918 PLEKHA5 - Pleckstrin homology domain-containing family A member 5 - Homo sapiens (Human) - PLEKHA5 gene cytosol, membrane, nucleoplasm, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding Indicus|evm.model.CM009495.1.774 Q4R7M8 CAZA3_MACFA 91.930 0.946667 1.00334 CAPZA3 - F-actin-capping protein subunit alpha-3 - Macaca fascicularis (Crab-eating macaque) - CAPZA3 gene F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity). Indicus|evm.model.CM009495.1.775 Q1RML2 PLCZ1_BOVIN 99.349 0.987118 0.979495 PLCZ1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 - Bos taurus (Bovine) - PLCZ1 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. Indicus|evm.model.CM009495.1.776 Q0II91 DJC21_BOVIN 69.932 0.992453 0.497186 DNAJC21 - DnaJ homolog subfamily C member 21 - Bos taurus (Bovine) - DNAJC21 gene May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. Indicus|evm.model.CM009495.1.777 Q0II91 DJC21_BOVIN 89.333 0.986667 0.281426 DNAJC21 - DnaJ homolog subfamily C member 21 - Bos taurus (Bovine) - DNAJC21 gene May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. Indicus|evm.model.CM009495.1.778 Q1RMH9 DNJC2_BOVIN 97.166 0.991935 0.399356 DNAJC2 - DnaJ homolog subfamily C member 2 - Bos taurus (Bovine) - DNAJC2 gene Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Indicus|evm.model.CM009495.1.779 O70173 P3C2G_RAT 79.019 0.65831 0.715615 Pik3c2g - Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma - Rattus norvegicus (Rat) - Pik3c2g gene Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity). Indicus|evm.model.CM009495.1.780 A6QP66 RERGL_BOVIN 100.000 0.990244 1.0049 RERGL - Ras-related and estrogen-regulated growth inhibitor-like protein - Bos taurus (Bovine) - RERGL gene Binds GDP/GTP and may possess intrinsic GTPase activity. Indicus|evm.model.CM009495.1.782 Q5RBW7 LMO3_PONAB 100.000 0.986301 1.0069 LMO3 - LIM domain only protein 3 - Pongo abelii (Sumatran orangutan) - LMO3 gene Indicus|evm.model.CM009495.1.783 Q0VCQ1 CTBP2_BOVIN 91.379 0.233607 0.548315 CTBP2 - C-terminal-binding protein 2 - Bos taurus (Bovine) - CTBP2 gene Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses. Indicus|evm.model.CM009495.1.784 Q64L89 MGST1_BOVIN 96.774 0.987179 1.00645 MGST1 - Microsomal glutathione S-transferase 1 - Bos taurus (Bovine) - MGST1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity (By similarity). Indicus|evm.model.CM009495.1.785 Q3T0V9 DEOC_BOVIN 99.371 0.99373 1.00314 DERA - Deoxyribose-phosphate aldolase - Bos taurus (Bovine) - DERA gene Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation. Indicus|evm.model.CM009495.1.786 Q5E959 STRAP_BOVIN 100.000 0.994302 1.00286 STRAP - Serine-threonine kinase receptor-associated protein - Bos taurus (Bovine) - STRAP gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity). Indicus|evm.model.CM009495.1.787 Q12929 EPS8_HUMAN 90.610 0.993902 0.997567 EPS8 - Epidermal growth factor receptor kinase substrate 8 - Homo sapiens (Human) - EPS8 gene Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. Indicus|evm.model.CM009495.1.788 Q16827 PTPRO_HUMAN 93.257 0.998318 0.977796 PTPRO - Receptor-type tyrosine-protein phosphatase O precursor - Homo sapiens (Human) - PTPRO gene Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity). Indicus|evm.model.CM009495.1.790 Q0VCJ7 RERG_BOVIN 100.000 0.99 1.00503 RERG - Ras-related and estrogen-regulated growth inhibitor - Bos taurus (Bovine) - RERG gene Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP (By similarity). Indicus|evm.model.CM009495.1.791 P22571 CNCG_BOVIN 100.000 0.97619 1.01205 PDE6H - Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma - Bos taurus (Bovine) - PDE6H gene Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Indicus|evm.model.CM009495.1.792 Q9TU03 GDIR2_BOVIN 100.000 0.728938 1.365 ARHGDIB - Rho GDP-dissociation inhibitor 2 - Bos taurus (Bovine) - ARHGDIB gene Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members. Indicus|evm.model.CM009495.1.793 Q32L47 ERP27_BOVIN 100.000 0.992674 1.00368 ERP27 - Endoplasmic reticulum resident protein 27 precursor - Bos taurus (Bovine) - ERP27 gene Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates. Binds protein substrates via a hydrophobic pocket in the C-terminal domain. May play a role in the unfolded stress response. Indicus|evm.model.CM009495.1.794 P07507 MGP_BOVIN 100.000 0.980769 1.00971 MGP - Matrix Gla protein precursor - Bos taurus (Bovine) - MGP gene Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. Indicus|evm.model.CM009495.1.795 Q95NE0 NAR4_PANTR 66.129 0.938272 1.03185 ART4 - Ecto-ADP-ribosyltransferase 4 precursor - Pan troglodytes (Chimpanzee) - ART4 gene NAD+ ADP-ribosyltransferase activity, peptidyl-arginine ADP-ribosylation Indicus|evm.model.CM009495.1.796 Q5U649 CL060_HUMAN 66.803 0.991632 0.97551 C12orf60 - Uncharacterized protein C12orf60 - Homo sapiens (Human) - C12orf60 gene Indicus|evm.model.CM009495.1.797 A2RU48 SMCO3_HUMAN 91.556 0.99115 1.00444 SMCO3 - Single-pass membrane and coiled-coil domain-containing protein 3 - Homo sapiens (Human) - SMCO3 gene Indicus|evm.model.CM009495.1.798 Q9Y2W2 WBP11_HUMAN 97.352 0.99688 1 WBP11 - WW domain-binding protein 11 - Homo sapiens (Human) - WBP11 gene Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. Indicus|evm.model.CM009495.1.799 Q9BTM1 H2AJ_HUMAN 100.000 0.984615 1.00775 H2AJ - Histone H2A.J - Homo sapiens (Human) - H2AJ gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009495.1.800 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009495.1.801 P55204 GUC2C_PIG 92.824 0.998136 1 GUCY2C - Heat-stable enterotoxin receptor precursor - Sus scrofa (Pig) - GUCY2C gene Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin (By similarity). Indicus|evm.model.CM009495.1.802 Q9GL30 PLBL1_BOVIN 100.000 0.996337 1.00183 PLBD1 - Phospholipase B-like 1 precursor - Bos taurus (Bovine) - PLBD1 gene Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids (By similarity). However, in view of the small size of the putative binding pocket, it has been proposed that it may act rather as an amidase or a peptidase (PubMed:23934913). Indicus|evm.model.CM009495.1.803 Q6VMQ6 MCAF1_HUMAN 80.350 0.998295 0.923622 ATF7IP - Activating transcription factor 7-interacting protein 1 - Homo sapiens (Human) - ATF7IP gene Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). Indicus|evm.model.CM009495.1.804 Q13224 NMDE2_HUMAN 100.000 0.883117 0.103774 GRIN2B - Glutamate receptor ionotropic, NMDA 2B precursor - Homo sapiens (Human) - GRIN2B gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity). Indicus|evm.model.CM009495.1.806 Q01097 NMDE2_MOUSE 99.015 0.765152 0.178138 Grin2b - Glutamate receptor ionotropic, NMDA 2B precursor - Mus musculus (Mouse) - Grin2b gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1377365, PubMed:26912815). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:1377365). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (PubMed:20141836). Contributes to neural pattern formation in the developing brain (PubMed:8789948). Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (PubMed:8789948). Indicus|evm.model.CM009495.1.807 Q01097 NMDE2_MOUSE 95.177 0.976411 0.800945 Grin2b - Glutamate receptor ionotropic, NMDA 2B precursor - Mus musculus (Mouse) - Grin2b gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1377365, PubMed:26912815). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:1377365). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (PubMed:20141836). Contributes to neural pattern formation in the developing brain (PubMed:8789948). Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (PubMed:8789948). Indicus|evm.model.CM009495.1.808 P54850 EMP1_RABIT 81.875 0.987578 1.00625 EMP1 - Epithelial membrane protein 1 - Oryctolagus cuniculus (Rabbit) - EMP1 gene Indicus|evm.model.CM009495.1.809 Q3SZT1 GSG1_BOVIN 87.912 0.952756 1.17957 GSG1 - Germ cell-specific gene 1 protein - Bos taurus (Bovine) - GSG1 gene May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum. Indicus|evm.model.CM009495.1.810 A2RU67 F234B_HUMAN 88.443 0.996795 1.00322 FAM234B - Protein FAM234B - Homo sapiens (Human) - FAM234B gene Indicus|evm.model.CM009495.1.811 Q148C9 HEBP1_BOVIN 100.000 0.989583 1.00524 HEBP1 - Heme-binding protein 1 - Bos taurus (Bovine) - HEBP1 gene May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity). Indicus|evm.model.CM009495.1.812 Q9NZD1 GPC5D_HUMAN 85.099 0.990132 0.881159 GPRC5D - G-protein coupled receptor family C group 5 member D - Homo sapiens (Human) - GPRC5D gene extracellular exosome, intracellular membrane-bounded organelle, plasma membrane, receptor complex, protein kinase activator activity Indicus|evm.model.CM009495.1.813 Q8NFJ5 RAI3_HUMAN 76.190 0.994413 1.0028 GPRC5A - Retinoic acid-induced protein 3 - Homo sapiens (Human) - GPRC5A gene Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). Indicus|evm.model.CM009495.1.814 Q29S22 DDX47_BOVIN 99.781 0.99345 1.00219 DDX47 - Probable ATP-dependent RNA helicase DDX47 - Bos taurus (Bovine) - DDX47 gene Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors (By similarity). Indicus|evm.model.CM009495.1.815 Q96LR9 APLD1_HUMAN 90.650 0.991903 0.885305 APOLD1 - Apolipoprotein L domain-containing protein 1 - Homo sapiens (Human) - APOLD1 gene May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability. Indicus|evm.model.CM009495.1.816 O19001 CDN1B_FELCA 93.939 0.98995 1.00505 CDKN1B - Cyclin-dependent kinase inhibitor 1B - Felis catus (Cat) - CDKN1B gene Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. Indicus|evm.model.CM009495.1.817 Q15760 GPR19_HUMAN 91.084 0.990431 1.00723 GPR19 - Probable G-protein coupled receptor 19 - Homo sapiens (Human) - GPR19 gene Orphan receptor. Indicus|evm.model.CM009495.1.818 Q0VD32 CRBL2_BOVIN 100.000 0.887218 1.10833 CREBL2 - cAMP-responsive element-binding protein-like 2 - Bos taurus (Bovine) - CREBL2 gene Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Indicus|evm.model.CM009495.1.819 Q9BY84 DUS16_HUMAN 100.000 0.138122 0.816541 DUSP16 - Dual specificity protein phosphatase 16 - Homo sapiens (Human) - DUSP16 gene Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. Indicus|evm.model.CM009495.1.820 Q08DP2 BORC5_BOVIN 100.000 0.703971 1.41327 BORCS5 - BLOC-1-related complex subunit 5 - Bos taurus (Bovine) - BORCS5 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility. Indicus|evm.model.CM009495.1.822 Q9H8J5 MANS1_HUMAN 59.447 0.995169 0.960557 MANSC1 - MANSC domain-containing protein 1 precursor - Homo sapiens (Human) - MANSC1 gene Indicus|evm.model.CM009495.1.824 O75581 LRP6_HUMAN 98.450 0.998761 1.00062 LRP6 - Low-density lipoprotein receptor-related protein 6 precursor - Homo sapiens (Human) - LRP6 gene Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). Indicus|evm.model.CM009495.1.825 Q5E9L4 B2L14_BOVIN 90.305 0.994475 1.11043 BCL2L14 - Apoptosis facilitator Bcl-2-like protein 14 - Bos taurus (Bovine) - BCL2L14 gene Plays a role in apoptosis. Indicus|evm.model.CM009495.1.826 Q0VC65 ETV6_BOVIN 95.952 0.928571 0.99115 ETV6 - Transcription factor ETV6 - Bos taurus (Bovine) - ETV6 gene Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. Indicus|evm.model.CM009495.1.832 Q645V9 TA2R9_PONPY 58.929 0.916667 0.192308 TAS2R9 - Taste receptor type 2 member 9 - Pongo pygmaeus (Bornean orangutan) - TAS2R9 gene Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). Indicus|evm.model.CM009495.1.833 P0DMW3 SIML1_HUMAN 92.857 0.797101 1.01471 SMIM10L1 - Small integral membrane protein 10-like protein 1 - Homo sapiens (Human) - SMIM10L1 gene Indicus|evm.model.CM009495.1.836 Q62764 YBOX3_RAT 91.054 0.824934 1.04432 Ybx3 - Y-box-binding protein 3 - Rattus norvegicus (Rat) - Ybx3 gene Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). Indicus|evm.model.CM009495.1.837 Q6J9G0 STYK1_HUMAN 76.540 0.983645 1.01422 STYK1 - Tyrosine-protein kinase STYK1 - Homo sapiens (Human) - STYK1 gene Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). Indicus|evm.model.CM009495.1.838 Q0VC92 MGN2_BOVIN 100.000 0.986577 1.00676 MAGOHB - Protein mago nashi homolog 2 - Bos taurus (Bovine) - MAGOHB gene Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway. Indicus|evm.model.CM009495.1.840 Q95MI5 NKG2A_PANTR 60.526 0.974138 0.497854 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Pan troglodytes (Chimpanzee) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Upon MHC-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Indicus|evm.model.CM009495.1.842 Q95MI5 NKG2A_PANTR 55.128 0.983122 1.01717 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Pan troglodytes (Chimpanzee) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Upon MHC-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Indicus|evm.model.CM009495.1.843 P26715 NKG2A_HUMAN 59.140 0.793103 0.497854 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Homo sapiens (Human) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9486650, PubMed:18083576, PubMed:9430220). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). Indicus|evm.model.CM009495.1.845 P26715 NKG2A_HUMAN 56.410 0.983051 1.01288 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Homo sapiens (Human) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9486650, PubMed:18083576, PubMed:9430220). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). Indicus|evm.model.CM009495.1.847 Q8CJC7 KLRE1_MOUSE 55.696 0.903846 1.15044 Klre1 - Killer cell lectin-like receptor subfamily E member 1 - Mus musculus (Mouse) - Klre1 gene Lectin-like receptor for natural killer (NK) cells (PubMed:14707119, PubMed:15069013, PubMed:18713988). Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner (PubMed:14707119, PubMed:15069013, PubMed:18713988). Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation (PubMed:18713988). Plays a role in allogeneic recognition by the immune system (PubMed:14707119, PubMed:15069013). Indicus|evm.model.CM009495.1.848 Q5BIZ2 GBRL1_XENTR 100.000 0.983051 1.00855 gabarapl1 - Gamma-aminobutyric acid receptor-associated protein-like 1 precursor - Xenopus tropicalis (Western clawed frog) - gabarapl1 gene Involved in autophagy. Indicus|evm.model.CM009495.1.849 Q0VBF2 TM52B_MOUSE 84.211 0.928962 0.983871 Tmem52b - Transmembrane protein 52B precursor - Mus musculus (Mouse) - Tmem52b gene Indicus|evm.model.CM009495.1.850 P79391 OLR1_BOVIN 98.535 0.992701 1.01481 OLR1 - Oxidized low-density lipoprotein receptor 1 - Bos taurus (Bovine) - OLR1 gene Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Indicus|evm.model.CM009495.1.851 Q49BZ4 CLC7A_BOVIN 100.000 0.991935 1.00405 CLEC7A - C-type lectin domain family 7 member A - Bos taurus (Bovine) - CLEC7A gene Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans. Indicus|evm.model.CM009495.1.852 Q0VCS6 CLC1A_BOVIN 100.000 0.992832 1.0036 CLEC1A - C-type lectin domain family 1 member A - Bos taurus (Bovine) - CLEC1A gene Indicus|evm.model.CM009495.1.853 Q6UXN8 CLC9A_HUMAN 70.954 0.84507 1.17842 CLEC9A - C-type lectin domain family 9 member A - Homo sapiens (Human) - CLEC9A gene Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. Indicus|evm.model.CM009495.1.854 Q9P126 CLC1B_HUMAN 68.421 0.986784 0.991266 CLEC1B - C-type lectin domain family 1 member B - Homo sapiens (Human) - CLEC1B gene C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485). Indicus|evm.model.CM009495.1.855 Q2NL33 CL12B_BOVIN 98.936 0.37931 1.78623 CLEC12B - C-type lectin domain family 12 member B - Bos taurus (Bovine) - CLEC12B gene Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases (By similarity). Indicus|evm.model.CM009495.1.858 Q6UVW9 CLC2A_HUMAN 71.111 0.656566 1.13793 CLEC2A - C-type lectin domain family 2 member A - Homo sapiens (Human) - CLEC2A gene Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. Indicus|evm.model.CM009495.1.859 D3W0D1 KLRF2_HUMAN 57.466 0.990991 1.07246 KLRF2 - Killer cell lectin-like receptor subfamily F member 2 - Homo sapiens (Human) - KLRF2 gene C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A. Indicus|evm.model.CM009495.1.860 Q92478 CLC2B_HUMAN 53.571 0.769663 1.19463 CLEC2B - C-type lectin domain family 2 member B - Homo sapiens (Human) - CLEC2B gene external side of plasma membrane, integral component of plasma membrane, plasma membrane, carbohydrate binding, identical protein binding, regulation of immune response Indicus|evm.model.CM009495.1.861 Q0H8B9 CL2DB_RAT 62.931 0.804196 0.690821 Clec2d11 - C-type lectin domain family 2 member D11 - Rattus norvegicus (Rat) - Clec2d11 gene Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis. Indicus|evm.model.CM009495.1.862 Q8C1T8 CLC2H_MOUSE 53.409 0.877551 0.899083 Clec2h - C-type lectin domain family 2 member H - Mus musculus (Mouse) - Clec2h gene Lectin-type cell surface receptor. Indicus|evm.model.CM009495.1.863 Q0H8B9 CL2DB_RAT 54.749 0.907692 0.942029 Clec2d11 - C-type lectin domain family 2 member D11 - Rattus norvegicus (Rat) - Clec2d11 gene Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis. Indicus|evm.model.CM009495.1.864 Q148C9 HEBP1_BOVIN 98.429 0.989583 1.00524 HEBP1 - Heme-binding protein 1 - Bos taurus (Bovine) - HEBP1 gene May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity). Indicus|evm.model.CM009495.1.865 Q07108 CD69_HUMAN 62.312 0.980198 1.01508 CD69 - Early activation antigen CD69 - Homo sapiens (Human) - CD69 gene Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. Indicus|evm.model.CM009495.1.868 Q0H8B9 CL2DB_RAT 52.299 0.822967 1.00966 Clec2d11 - C-type lectin domain family 2 member D11 - Rattus norvegicus (Rat) - Clec2d11 gene Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis. Indicus|evm.model.CM009495.1.869 Q6IE36 OVOS2_HUMAN 69.847 0.501587 1.97975 OVOS2 - Ovostatin homolog 2 precursor - Homo sapiens (Human) - OVOS2 gene Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. Indicus|evm.model.CM009495.1.870 Q7SIH1 A2MG_BOVIN 97.285 0.998644 0.976821 A2M - Alpha-2-macroglobulin precursor - Bos taurus (Bovine) - A2M gene Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Indicus|evm.model.CM009495.1.871 Q96E93 KLRG1_HUMAN 62.963 0.800866 1.18462 KLRG1 - Killer cell lectin-like receptor subfamily G member 1 - Homo sapiens (Human) - KLRG1 gene Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. Indicus|evm.model.CM009495.1.872 Q5E995 RS6_BOVIN 81.538 0.615385 0.417671 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009495.1.873 P11456 MPRD_BOVIN 100.000 0.992832 1 M6PR - Cation-dependent mannose-6-phosphate receptor precursor - Bos taurus (Bovine) - M6PR gene Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Indicus|evm.model.CM009495.1.874 P78364 PHC1_HUMAN 94.627 0.405691 2.4502 PHC1 - Polyhomeotic-like protein 1 - Homo sapiens (Human) - PHC1 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. Indicus|evm.model.CM009495.1.875 Q0VCE9 RIMKB_BOVIN 100.000 0.909091 0.797927 RIMKLB - Beta-citrylglutamate synthase B - Bos taurus (Bovine) - RIMKLB gene Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate. Indicus|evm.model.CM009495.1.876 Q28022 MFAP5_BOVIN 99.412 0.642586 1.54706 MFAP5 - Microfibrillar-associated protein 5 precursor - Bos taurus (Bovine) - MFAP5 gene May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (By similarity). Indicus|evm.model.CM009495.1.877 Q2PT36 AICDA_BOVIN 99.301 0.8875 0.80402 AICDA - Single-stranded DNA cytosine deaminase - Bos taurus (Bovine) - AICDA gene Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Indicus|evm.model.CM009495.1.880 Q9NR23 GDF3_HUMAN 78.689 0.994521 1.00275 GDF3 - Growth/differentiation factor 3 precursor - Homo sapiens (Human) - GDF3 gene Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089). Indicus|evm.model.CM009495.1.881 A9Q1J7 DPPA3_BOVIN 100.000 0.987805 1.00613 DPPA3 - Developmental pluripotency-associated protein 3 - Bos taurus (Bovine) - DPPA3 gene Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity). Indicus|evm.model.CM009495.1.882 A5GFY4 NELFD_PIG 78.571 0.994872 0.991525 NELFCD - Negative elongation factor D - Sus scrofa (Pig) - NELFCD gene Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). Indicus|evm.model.CM009495.1.883 Q4JM65 NANOG_BOVIN 100.000 0.665924 1.49667 NANOG - Homeobox protein NANOG - Bos taurus (Bovine) - NANOG gene Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator and repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity). Indicus|evm.model.CM009495.1.884 P58352 GTR3_BOVIN 99.388 0.983903 1.00607 SLC2A3 - Solute carrier family 2, facilitated glucose transporter member 3 - Bos taurus (Bovine) - SLC2A3 gene Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Indicus|evm.model.CM009495.1.885 Q9P0K8 FOXJ2_HUMAN 88.000 0.748663 1.30314 FOXJ2 - Forkhead box protein J2 - Homo sapiens (Human) - FOXJ2 gene Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). Indicus|evm.model.CM009495.1.886 Q16581 C3AR_HUMAN 71.310 0.989627 1 C3AR1 - C3a anaphylatoxin chemotactic receptor - Homo sapiens (Human) - C3AR1 gene Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. Indicus|evm.model.CM009495.1.887 Q3T093 NECP1_BOVIN 100.000 0.992754 1.00364 NECAP1 - Adaptin ear-binding coat-associated protein 1 - Bos taurus (Bovine) - NECAP1 gene Involved in endocytosis. Indicus|evm.model.CM009495.1.888 Q9UMR7 CLC4A_HUMAN 60.166 0.991597 1.00422 CLEC4A - C-type lectin domain family 4 member A - Homo sapiens (Human) - CLEC4A gene C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner (PubMed:27015765). Involved in regulating immune reactivity (PubMed:18258799, PubMed:10438934). Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 (PubMed:18258799, PubMed:20530286). In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (PubMed:18258799). May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:10438934). Indicus|evm.model.CM009495.1.889 P84104 SRSF3_MOUSE 100.000 0.987879 1.0061 Srsf3 - Serine/arginine-rich splicing factor 3 - Mus musculus (Mouse) - Srsf3 gene Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. RNA-binding is semi-sequence specific. Indicus|evm.model.CM009495.1.890 Q3LUH2 CLC6A_BOVIN 100.000 0.990338 1.00485 CLEC6A - C-type lectin domain family 6 member A - Bos taurus (Bovine) - CLEC6A gene Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (By similarity). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity). Indicus|evm.model.CM009495.1.891 Q9ULY5 CLC4E_HUMAN 76.531 0.514512 1.73059 CLEC4E - C-type lectin domain family 4 member E - Homo sapiens (Human) - CLEC4E gene Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109, PubMed:23602766). The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766, PubMed:24101491). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (By similarity). Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (By similarity). Indicus|evm.model.CM009495.1.892 P85521 C163A_BOVIN 99.909 0.992799 0.984057 CD163 - Scavenger receptor cysteine-rich type 1 protein M130 precursor - Bos taurus (Bovine) - CD163 gene Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). Indicus|evm.model.CM009495.1.894 P30205 WC11_BOVIN 83.673 0.971239 0.629526 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.895 P30205 WC11_BOVIN 87.706 0.991329 0.722841 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.896 P30205 WC11_BOVIN 78.446 0.994269 0.243036 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.897 P30205 WC11_BOVIN 85.764 0.998611 1.00279 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.898 P30205 WC11_BOVIN 77.097 0.997948 1.01811 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.899 P30205 WC11_BOVIN 64.143 0.695286 0.413649 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.900 P30205 WC11_BOVIN 60.542 0.985884 0.937326 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.903 P30205 WC11_BOVIN 75.354 0.746822 0.657382 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.904 P30205 WC11_BOVIN 81.761 0.61241 1.63858 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.905 Q9NR16 C163B_HUMAN 78.125 0.437788 0.149346 CD163L1 - Scavenger receptor cysteine-rich type 1 protein M160 precursor - Homo sapiens (Human) - CD163L1 gene external side of plasma membrane Indicus|evm.model.CM009495.1.906 Q99627 CSN8_HUMAN 94.258 0.990476 1.00478 COPS8 - COP9 signalosome complex subunit 8 - Homo sapiens (Human) - COPS8 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Indicus|evm.model.CM009495.1.907 P30205 WC11_BOVIN 88.177 0.384321 0.364206 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.908 P30205 WC11_BOVIN 72.784 0.672061 1.46309 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.909 P30205 WC11_BOVIN 76.652 0.77969 0.404596 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.910 P30205 WC11_BOVIN 78.904 0.615211 0.924791 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.911 Q99627 CSN8_HUMAN 94.258 0.990476 1.00478 COPS8 - COP9 signalosome complex subunit 8 - Homo sapiens (Human) - COPS8 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Indicus|evm.model.CM009495.1.912 P30205 WC11_BOVIN 80.565 0.625866 0.301532 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.913 P30205 WC11_BOVIN 97.563 0.998608 1.0007 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.914 P30205 WC11_BOVIN 71.672 0.535185 0.376045 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.915 Q1RMV0 PEX5_BOVIN 100.000 0.99688 1.00156 PEX5 - Peroxisomal targeting signal 1 receptor - Bos taurus (Bovine) - PEX5 gene Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Indicus|evm.model.CM009495.1.916 Q0VCN6 CSTN3_BOVIN 100.000 0.997912 1.00104 CLSTN3 - Calsyntenin-3 precursor - Bos taurus (Bovine) - CLSTN3 gene May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. Indicus|evm.model.CM009495.1.917 P82708 RET5_BOVIN 100.000 0.170058 5.0963 RBP5 - Retinol-binding protein 5 - Bos taurus (Bovine) - RBP5 gene Intracellular transport of retinol. Indicus|evm.model.CM009495.1.918 Q5R1W3 C1R_PANTR 73.353 0.783529 0.602837 C1R - Complement C1r subcomponent precursor - Pan troglodytes (Chimpanzee) - C1R gene C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Indicus|evm.model.CM009495.1.919 P00736 C1R_HUMAN 66.754 0.686391 0.719149 C1R - Complement C1r subcomponent precursor - Homo sapiens (Human) - C1R gene C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Indicus|evm.model.CM009495.1.920 Q5R544 C1R_PONAB 80.966 0.952575 1.04681 C1R - Complement C1r subcomponent precursor - Pongo abelii (Sumatran orangutan) - C1R gene C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Indicus|evm.model.CM009495.1.921 Q0VCX1 C1S_BOVIN 99.855 0.988506 1.01016 C1S - Complement C1s subcomponent precursor - Bos taurus (Bovine) - C1S gene C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). Indicus|evm.model.CM009495.1.922 Q3SZL3 MBOA5_BOVIN 86.000 0.628205 0.160825 LPCAT3 - Lysophospholipid acyltransferase 5 - Bos taurus (Bovine) - LPCAT3 gene Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle. Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (By similarity). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency. Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus. Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Downregulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins. In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly. In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity). Indicus|evm.model.CM009495.1.923 Q3SZL3 MBOA5_BOVIN 99.542 0.95614 0.940206 LPCAT3 - Lysophospholipid acyltransferase 5 - Bos taurus (Bovine) - LPCAT3 gene Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle. Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (By similarity). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency. Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus. Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Downregulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins. In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly. In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity). Indicus|evm.model.CM009495.1.924 Q92979 NEP1_HUMAN 91.803 0.698276 1.42623 EMG1 - Ribosomal RNA small subunit methyltransferase NEP1 - Homo sapiens (Human) - EMG1 gene S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Indicus|evm.model.CM009495.1.925 Q2HJ97 PHB2_BOVIN 93.312 0.993651 1.05351 PHB2 - Prohibitin-2 - Bos taurus (Bovine) - PHB2 gene Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. Indicus|evm.model.CM009495.1.926 P29350 PTN6_HUMAN 95.946 0.988294 1.00504 PTPN6 - Tyrosine-protein phosphatase non-receptor type 6 - Homo sapiens (Human) - PTPN6 gene Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. Indicus|evm.model.CM009495.1.927 Q32KM2 C10_BOVIN 100.000 0.984252 0.962121 Protein C10 - Bos taurus (Bovine) Indicus|evm.model.CM009495.1.928 Q5IS70 ATN1_PANTR 95.029 0.998309 0.99747 ATN1 - Atrophin-1 - Pan troglodytes (Chimpanzee) - ATN1 gene Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Recruits NR2E1 to repress transcription. Has some intrinsic repression activity. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Indicus|evm.model.CM009495.1.929 P09104 ENOG_HUMAN 98.618 0.995402 1.0023 ENO2 - Gamma-enolase - Homo sapiens (Human) - ENO2 gene Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). Indicus|evm.model.CM009495.1.930 Q32KP2 LRC23_BOVIN 99.708 0.994169 1.00292 LRRC23 - Leucine-rich repeat-containing protein 23 - Bos taurus (Bovine) - LRRC23 gene Indicus|evm.model.CM009495.1.931 Q99619 SPSB2_HUMAN 92.395 0.891156 1.11787 SPSB2 - SPRY domain-containing SOCS box protein 2 - Homo sapiens (Human) - SPSB2 gene Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Indicus|evm.model.CM009495.1.932 Q5E956 TPIS_BOVIN 100.000 0.864111 1.15261 TPI1 - Triosephosphate isomerase - Bos taurus (Bovine) - TPI1 gene Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. Indicus|evm.model.CM009495.1.933 P56399 UBP5_MOUSE 95.338 0.997608 0.974359 Usp5 - Ubiquitin carboxyl-terminal hydrolase 5 - Mus musculus (Mouse) - Usp5 gene Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity). Indicus|evm.model.CM009495.1.934 Q99618 CDCA3_HUMAN 80.224 0.992481 0.992537 CDCA3 - Cell division cycle-associated protein 3 - Homo sapiens (Human) - CDCA3 gene F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). Indicus|evm.model.CM009495.1.935 P79147 GBB3_CANLF 97.941 0.994135 1.00294 GNB3 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 - Canis lupus familiaris (Dog) - GNB3 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009495.1.936 Q8IVL6 P3H3_HUMAN 87.751 0.99633 0.740489 P3H3 - Prolyl 3-hydroxylase 3 precursor - Homo sapiens (Human) - P3H3 gene Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases. Indicus|evm.model.CM009495.1.937 Q16538 GP162_HUMAN 93.707 0.996503 0.972789 GPR162 - Probable G-protein coupled receptor 162 - Homo sapiens (Human) - GPR162 gene Orphan receptor. Indicus|evm.model.CM009495.1.938 P18627 LAG3_HUMAN 72.892 0.481407 1.89524 LAG3 - Lymphocyte activation gene 3 protein precursor - Homo sapiens (Human) - LAG3 gene Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185). Indicus|evm.model.CM009495.1.939 P04550 PTMS_RAT 91.954 0.86 0.980392 Ptms - Parathymosin - Rattus norvegicus (Rat) - Ptms gene Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections. Indicus|evm.model.CM009495.1.940 Q15773 MLF2_HUMAN 97.581 0.991935 1 MLF2 - Myeloid leukemia factor 2 - Homo sapiens (Human) - MLF2 gene cytoplasm, membrane, nucleus, regulation of transcription, DNA-templated Indicus|evm.model.CM009495.1.941 P61247 RS3A_HUMAN 94.444 0.967568 0.700758 RPS3A - 40S ribosomal protein S3a - Homo sapiens (Human) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009495.1.942 Q5R762 CSN7A_PONAB 99.636 0.992754 1.00364 COPS7A - COP9 signalosome complex subunit 7a - Pongo abelii (Sumatran orangutan) - COPS7A gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Indicus|evm.model.CM009495.1.943 Q5U2P6 PIANP_RAT 97.845 0.249191 3.40809 Pianp - PILR alpha-associated neural protein precursor - Rattus norvegicus (Rat) - Pianp gene Acts as a ligand for PILRA in neuronal tissues, where it may be involved in immune regulation. Indicus|evm.model.CM009495.1.944 Q3T095 ING4_BOVIN 99.597 0.991968 1.00403 ING4 - Inhibitor of growth protein 4 - Bos taurus (Bovine) - ING4 gene Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). Indicus|evm.model.CM009495.1.945 Q29016 ACRBP_PIG 89.210 0.950276 1.00742 ACRBP - Acrosin-binding protein precursor - Sus scrofa (Pig) - ACRBP gene Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome (PubMed:8144514). Involved also in the acrosome formation (By similarity). Indicus|evm.model.CM009495.1.946 Q3ZC80 LPAR5_BOVIN 100.000 0.994565 1.00272 LPAR5 - Lysophosphatidic acid receptor 5 - Bos taurus (Bovine) - LPAR5 gene Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Indicus|evm.model.CM009495.1.947 Q14839 CHD4_HUMAN 98.431 0.697181 1.42835 CHD4 - Chromodomain-helicase-DNA-binding protein 4 - Homo sapiens (Human) - CHD4 gene Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Indicus|evm.model.CM009495.1.948 Q8BXL9 IFFO1_MOUSE 93.530 0.886513 1.08185 Iffo1 - Non-homologous end joining factor IFFO1 - Mus musculus (Mouse) - Iffo1 gene Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that will relocalize to the DSB sites in a XRCC4-dependent manner and promote the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). Indicus|evm.model.CM009495.1.949 P10096 G3P_BOVIN 100.000 0.994012 1.003 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Bos taurus (Bovine) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Indicus|evm.model.CM009495.1.950 Q15021 CND1_HUMAN 87.223 0.998569 0.997859 NCAPD2 - Condensin complex subunit 1 - Homo sapiens (Human) - NCAPD2 gene Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Indicus|evm.model.CM009495.1.951 P0C2B6 RM51_BOVIN 100.000 0.984496 1.00781 MRPL51 - 39S ribosomal protein L51, mitochondrial precursor - Bos taurus (Bovine) - MRPL51 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, structural constituent of ribosome, mitochondrial translation, translation Indicus|evm.model.CM009495.1.953 Q0V7N0 VAMP1_BOVIN 100.000 0.590426 1.59322 VAMP1 - Vesicle-associated membrane protein 1 - Bos taurus (Bovine) - VAMP1 gene Involved in the targeting and/or fusion of transport vesicles to their target membrane. Indicus|evm.model.CM009495.1.954 Q5R8H1 TPSNR_PONAB 75.349 0.959368 0.946581 TAPBPL - Tapasin-related protein precursor - Pongo abelii (Sumatran orangutan) - TAPBPL gene Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. Indicus|evm.model.CM009495.1.955 P26842 CD27_HUMAN 72.656 0.976 0.961538 CD27 - CD27 antigen precursor - Homo sapiens (Human) - CD27 gene Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. Indicus|evm.model.CM009495.1.956 P36941 TNR3_HUMAN 69.953 0.986014 0.986207 LTBR - Tumor necrosis factor receptor superfamily member 3 precursor - Homo sapiens (Human) - LTBR gene Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. Indicus|evm.model.CM009495.1.957 P55270 SCNNA_BOVIN 91.692 0.948012 1.00615 SCNN1A - Amiloride-sensitive sodium channel subunit alpha - Bos taurus (Bovine) - SCNN1A gene Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Indicus|evm.model.CM009495.1.958 O19131 TNR1A_BOVIN 100.000 0.993644 1.00212 TNFRSF1A - Tumor necrosis factor receptor superfamily member 1A precursor - Bos taurus (Bovine) - TNFRSF1A gene Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). Indicus|evm.model.CM009495.1.959 Q3KR16 PKHG6_HUMAN 74.747 0.997406 0.975949 PLEKHG6 - Pleckstrin homology domain-containing family G member 6 - Homo sapiens (Human) - PLEKHG6 gene Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. Indicus|evm.model.CM009495.1.960 P30932 CD9_BOVIN 100.000 0.9875 0.707965 CD9 - CD9 antigen - Bos taurus (Bovine) - CD9 gene Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity). Indicus|evm.model.CM009495.1.961 P80012 VWF_BOVIN 95.535 0.339091 3.02775 VWF - von Willebrand factor precursor - Bos taurus (Bovine) - VWF gene Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Indicus|evm.model.CM009495.1.962 Q3ZBN8 TIM14_BOVIN 99.138 0.982906 1.00862 DNAJC19 - Mitochondrial import inner membrane translocase subunit TIM14 - Bos taurus (Bovine) - DNAJC19 gene Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). Indicus|evm.model.CM009495.1.963 Q9NQ90 ANO2_HUMAN 91.551 0.990405 0.935194 ANO2 - Anoctamin-2 - Homo sapiens (Human) - ANO2 gene Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. Indicus|evm.model.CM009495.1.964 Q08DT3 NTF3_BOVIN 99.571 0.991453 0.924901 NTF3 - Neurotrophin-3 precursor - Bos taurus (Bovine) - NTF3 gene Seems to promote the survival of visceral and proprioceptive sensory neurons. Indicus|evm.model.CM009495.1.966 P79197 KCNA5_MUSPF 90.216 0.996661 0.996672 KCNA5 - Potassium voltage-gated channel subfamily A member 5 - Mustela putorius furo (European domestic ferret) - KCNA5 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (By similarity). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (By similarity). May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity). Indicus|evm.model.CM009495.1.967 Q9EQC4 ELOV4_MOUSE 43.952 0.896552 0.836538 Elovl4 - Elongation of very long chain fatty acids protein 4 - Mus musculus (Mouse) - Elovl4 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. Indicus|evm.model.CM009495.1.968 Q09470 KCNA1_HUMAN 96.768 0.995968 1.00202 KCNA1 - Potassium voltage-gated channel subfamily A member 1 - Homo sapiens (Human) - KCNA1 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:12077175, PubMed:17156368). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:19968958, PubMed:19307729, PubMed:19903818). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses (PubMed:11026449, PubMed:17136396). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:23903368, PubMed:19307729). Indicus|evm.model.CM009495.1.970 P17658 KCNA6_HUMAN 95.660 0.996219 1 KCNA6 - Potassium voltage-gated channel subfamily A member 6 - Homo sapiens (Human) - KCNA6 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305). Indicus|evm.model.CM009495.1.972 Q9NY28 GALT8_HUMAN 73.418 0.993701 0.99686 GALNT8 - Probable polypeptide N-acetylgalactosaminyltransferase 8 - Homo sapiens (Human) - GALNT8 gene Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Indicus|evm.model.CM009495.1.973 P34943 NDUA9_BOVIN 100.000 0.994751 1.00263 NDUFA9 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor - Bos taurus (Bovine) - NDUFA9 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009495.1.974 O77797 AKAP3_BOVIN 99.883 0.997672 1.00117 AKAP3 - A-kinase anchor protein 3 - Bos taurus (Bovine) - AKAP3 gene May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Indicus|evm.model.CM009495.1.975 Q9NR20 DYRK4_HUMAN 81.190 0.8 1.25 DYRK4 - Dual specificity tyrosine-phosphorylation-regulated kinase 4 - Homo sapiens (Human) - DYRK4 gene Possible non-essential role in spermiogenesis. Indicus|evm.model.CM009495.1.976 Q96B01 R51A1_HUMAN 64.773 0.987768 0.928977 RAD51AP1 - RAD51-associated protein 1 - Homo sapiens (Human) - RAD51AP1 gene Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:9396801, PubMed:17996711, PubMed:22375013, PubMed:17996710). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27463890, PubMed:27239033, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). Indicus|evm.model.CM009495.1.977 Q5RD58 CL004_PONAB 96.196 0.996383 1.00181 Protein C12orf4 homolog - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009495.1.978 Q96B01 R51A1_HUMAN 64.773 0.987768 0.928977 RAD51AP1 - RAD51-associated protein 1 - Homo sapiens (Human) - RAD51AP1 gene Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:9396801, PubMed:17996711, PubMed:22375013, PubMed:17996710). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27463890, PubMed:27239033, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). Indicus|evm.model.CM009495.1.979 Q5RD58 CL004_PONAB 96.196 0.996383 1.00181 Protein C12orf4 homolog - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009495.1.980 P10767 FGF6_HUMAN 92.788 0.990431 1.00481 FGF6 - Fibroblast growth factor 6 precursor - Homo sapiens (Human) - FGF6 gene Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. Indicus|evm.model.CM009495.1.981 Q9GZV9 FGF23_HUMAN 76.892 0.987805 0.98008 FGF23 - Fibroblast growth factor 23 precursor - Homo sapiens (Human) - FGF23 gene Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Indicus|evm.model.CM009495.1.982 Q1JQA7 TIGAR_BOVIN 99.630 0.99262 1.0037 TIGAR - Fructose-2,6-bisphosphatase TIGAR - Bos taurus (Bovine) - TIGAR gene Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (By similarity). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity. In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage. Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation. Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions. Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner. Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses. Involved in intestinal tumor progression. Indicus|evm.model.CM009495.1.983 Q0P5D3 CCND2_BOVIN 100.000 0.993103 1.00346 CCND2 - G1/S-specific cyclin-D2 - Bos taurus (Bovine) - CCND2 gene Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). Indicus|evm.model.CM009495.1.985 Q9NR21 PAR11_HUMAN 95.181 0.831658 1.17751 PARP11 - Protein mono-ADP-ribosyltransferase PARP11 - Homo sapiens (Human) - PARP11 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). Indicus|evm.model.CM009495.1.987 Q9BSW2 EFC4B_HUMAN 82.650 0.997238 0.990424 CRACR2A - EF-hand calcium-binding domain-containing protein 4B - Homo sapiens (Human) - CRACR2A gene Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. Indicus|evm.model.CM009495.1.989 Q9NR22 ANM8_HUMAN 98.945 0.994737 0.964467 PRMT8 - Protein arginine N-methyltransferase 8 - Homo sapiens (Human) - PRMT8 gene S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed:18320585). Indicus|evm.model.CM009495.1.990 Q0VC33 TSN11_BOVIN 99.605 0.992126 1.00395 TSPAN11 - Tetraspanin-11 - Bos taurus (Bovine) - TSPAN11 gene integral component of plasma membrane, cell migration Indicus|evm.model.CM009495.1.991 B3VSC2 TSN9_SHEEP 97.490 0.719033 1.38494 TSPAN9 - Tetraspanin-9 - Ovis aries (Sheep) - TSPAN9 gene Indicus|evm.model.CM009495.1.992 Q15561 TEAD4_HUMAN 95.853 0.460638 2.1659 TEAD4 - Transcriptional enhancer factor TEF-3 - Homo sapiens (Human) - TEAD4 gene Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. Indicus|evm.model.CM009495.1.993 Q1LZE2 RHNO1_BOVIN 99.170 0.991736 1.00415 RHNO1 - RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 - Bos taurus (Bovine) - RHNO1 gene Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation (By similarity). Indicus|evm.model.CM009495.1.994 Q08050 FOXM1_HUMAN 78.343 0.992701 0.897772 FOXM1 - Forkhead box protein M1 - Homo sapiens (Human) - FOXM1 gene Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. Indicus|evm.model.CM009495.1.995 P97691 FOXM1_RAT 79.365 0.911765 0.0895916 Foxm1 - Forkhead box protein M1 - Rattus norvegicus (Rat) - Foxm1 gene Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response (By similarity). Indicus|evm.model.CM009495.1.996 A6NCN8 TEX52_HUMAN 71.484 0.962264 0.868852 TEX52 - Testis-expressed protein 52 - Homo sapiens (Human) - TEX52 gene Indicus|evm.model.CM009495.1.997 Q9BQI9 NRIP2_HUMAN 81.034 0.991416 0.829181 NRIP2 - Nuclear receptor-interacting protein 2 - Homo sapiens (Human) - NRIP2 gene Down-regulates transcriptional activation by nuclear receptors such as NR1F2. Indicus|evm.model.CM009495.1.998 Q27969 ITFG2_BOVIN 91.111 0.894382 0.836466 ITFG2 - KICSTOR complex protein ITFG2 - Bos taurus (Bovine) - ITFG2 gene As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. Indicus|evm.model.CM009495.1.999 Q9TRY0 FKBP4_BOVIN 100.000 0.995652 1.00218 FKBP4 - Peptidyl-prolyl cis-trans isomerase FKBP4 - Bos taurus (Bovine) - FKBP4 gene Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening (By similarity). Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria (By similarity). Indicus|evm.model.CM009495.1.1000 Q96FC9 DDX11_HUMAN 79.104 0.848356 0.972165 DDX11 - ATP-dependent DNA helicase DDX11 - Homo sapiens (Human) - DDX11 gene DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Plays also a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:9013641, PubMed:18499658, PubMed:22102414). Indicus|evm.model.CM009495.1.1001 A7Z063 WASH1_BOVIN 100.000 0.961145 1.03822 WASHC1 - WASH complex subunit 1 - Bos taurus (Bovine) - WASHC1 gene Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). Indicus|evm.model.CM009495.1.1002 Q9UPP2 IQEC3_HUMAN 82.882 0.893819 1.06768 IQSEC3 - IQ motif and SEC7 domain-containing protein 3 - Homo sapiens (Human) - IQSEC3 gene Acts as a guanine nucleotide exchange factor (GEF) for ARF1. Indicus|evm.model.CM009495.1.1003 P27799 S6A12_CANLF 87.602 0.990291 1.00651 SLC6A12 - Sodium- and chloride-dependent betaine transporter - Canis lupus familiaris (Dog) - SLC6A12 gene Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Indicus|evm.model.CM009495.1.1005 A5PJX7 S6A13_BOVIN 99.834 0.996683 1.00166 SLC6A13 - Sodium- and chloride-dependent GABA transporter 2 - Bos taurus (Bovine) - SLC6A13 gene Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport (By similarity). Indicus|evm.model.CM009495.1.1006 P29375 KDM5A_HUMAN 97.870 0.998817 1.00059 KDM5A - Lysine-specific demethylase 5A - Homo sapiens (Human) - KDM5A gene Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). Indicus|evm.model.CM009495.1.1008 Q9BR77 CCD77_HUMAN 78.296 0.995943 1.01025 CCDC77 - Coiled-coil domain-containing protein 77 - Homo sapiens (Human) - CCDC77 gene centrosome, membrane Indicus|evm.model.CM009495.1.1009 A8D8X1 RL10_SHEEP 98.936 0.0798283 5.44393 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009495.1.1010 Q9NZG7 NINJ2_HUMAN 72.059 0.957447 0.992958 NINJ2 - Ninjurin-2 - Homo sapiens (Human) - NINJ2 gene Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Indicus|evm.model.CM009495.1.1011 Q6R2V0 WNK1_PIG 91.195 0.356949 0.93266 WNK1 - Serine/threonine-protein kinase WNK1 - Sus scrofa (Pig) - WNK1 gene Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity). Indicus|evm.model.CM009495.1.1012 P43351 RAD52_HUMAN 67.813 0.788306 1.1866 RAD52 - DNA repair protein RAD52 homolog - Homo sapiens (Human) - RAD52 gene Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. Indicus|evm.model.CM009495.1.1013 Q8IUD2 RB6I2_HUMAN 94.892 0.998163 0.975806 ERC1 - ELKS/Rab6-interacting/CAST family member 1 - Homo sapiens (Human) - ERC1 gene Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Indicus|evm.model.CM009495.1.1014 Q8BID8 FXL14_MOUSE 100.000 0.995012 1.0025 Fbxl14 - F-box/LRR-repeat protein 14 - Mus musculus (Mouse) - Fbxl14 gene Substrate-recognition component of some (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). Indicus|evm.model.CM009495.1.1015 P22726 WNT5B_MOUSE 90.698 0.955432 1 Wnt5b - Protein Wnt-5b precursor - Mus musculus (Mouse) - Wnt5b gene Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Indicus|evm.model.CM009495.1.1016 Q86V24 PAQR2_HUMAN 92.228 0.994832 1.00259 ADIPOR2 - Adiponectin receptor protein 2 - Homo sapiens (Human) - ADIPOR2 gene Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity). Indicus|evm.model.CM009495.1.1017 Q7Z3S7 CA2D4_HUMAN 79.530 0.998193 0.973615 CACNA2D4 - Voltage-dependent calcium channel subunit alpha-2/delta-4 precursor - Homo sapiens (Human) - CACNA2D4 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Indicus|evm.model.CM009495.1.1018 Q3SZL6 DCP1B_BOVIN 99.656 0.996564 1.00172 DCP1B - mRNA-decapping enzyme 1B - Bos taurus (Bovine) - DCP1B gene May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). Indicus|evm.model.CM009495.1.1020 Q13936 CAC1C_HUMAN 98.863 0.987581 0.761369 CACNA1C - Voltage-dependent L-type calcium channel subunit alpha-1C - Homo sapiens (Human) - CACNA1C gene Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:23677916). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). Indicus|evm.model.CM009495.1.1021 P58780 ADA2_PIG 71.429 0.782258 0.243137 ADA2 - Adenosine deaminase 2 precursor - Sus scrofa (Pig) - ADA2 gene Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity). Indicus|evm.model.CM009495.1.1022 Q96F46 I17RA_HUMAN 66.626 0.936375 0.961894 IL17RA - Interleukin-17 receptor A precursor - Homo sapiens (Human) - IL17RA gene Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:24120361, PubMed:17911633, PubMed:18684971, PubMed:21350122). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Indicus|evm.model.CM009495.1.1023 Q9BXW7 HDHD5_HUMAN 71.327 0.995025 0.950355 HDHD5 - Haloacid dehalogenase-like hydrolase domain-containing 5 precursor - Homo sapiens (Human) - HDHD5 gene mitochondrion, glycerophospholipid biosynthetic process Indicus|evm.model.CM009495.1.1024 P58780 ADA2_PIG 80.337 0.880893 0.790196 ADA2 - Adenosine deaminase 2 precursor - Sus scrofa (Pig) - ADA2 gene Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity). Indicus|evm.model.CM009495.1.1025 Q9BXF3 CECR2_HUMAN 69.184 0.991131 0.911725 CECR2 - Cat eye syndrome critical region protein 2 - Homo sapiens (Human) - CECR2 gene Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex (PubMed:15640247, PubMed:26365797, PubMed:22464331). It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797, PubMed:22464331). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed:11827465). Indicus|evm.model.CM009495.1.1026 P11019 VATE1_BOVIN 100.000 0.991189 1.00442 ATP6V1E1 - V-type proton ATPase subunit E 1 - Bos taurus (Bovine) - ATP6V1E1 gene Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Indicus|evm.model.CM009495.1.1027 Q9BXK5 B2L13_HUMAN 68.776 0.995444 0.905155 BCL2L13 - Bcl-2-like protein 13 - Homo sapiens (Human) - BCL2L13 gene May promote the activation of caspase-3 and apoptosis. Indicus|evm.model.CM009495.1.1028 G3MWR8 MICA3_BOVIN 98.440 0.857081 1.18163 MICAL3 - [F-actin]-monooxygenase MICAL3 - Bos taurus (Bovine) - MICAL3 gene Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and play a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. Indicus|evm.model.CM009495.1.1030 Q7Z412 PEX26_HUMAN 78.289 0.990033 0.986885 PEX26 - Peroxisome assembly protein 26 - Homo sapiens (Human) - PEX26 gene Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence. Indicus|evm.model.CM009495.1.1031 Q2HJB8 TBA8_BOVIN 100.000 0.995556 1.00223 TUBA8 - Tubulin alpha-8 chain - Bos taurus (Bovine) - TUBA8 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Indicus|evm.model.CM009495.1.1032 Q17QW1 BORG5_BOVIN 98.615 0.994475 1.00277 CDC42EP1 - Cdc42 effector protein 1 - Bos taurus (Bovine) - CDC42EP1 gene Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity). Indicus|evm.model.CM009495.1.1033 Q29373 LEG2_PIG 79.279 0.901639 0.99187 LGALS2 - Galectin-2 - Sus scrofa (Pig) - LGALS2 gene This protein binds beta-galactoside. Its physiological function is not yet known (By similarity). Indicus|evm.model.CM009495.1.1034 Q9UJY5 GGA1_HUMAN 92.175 0.996805 0.979656 GGA1 - ADP-ribosylation factor-binding protein GGA1 - Homo sapiens (Human) - GGA1 gene Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15886016, PubMed:15615712). Indicus|evm.model.CM009495.1.1035 Q6ZT62 BGIN_HUMAN 86.891 0.756484 1.02511 BARGIN - Bargin - Homo sapiens (Human) - BARGIN gene GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains. Indicus|evm.model.CM009495.1.1036 Q3ZBF9 PLPP_BOVIN 99.324 0.993266 1.00338 PDXP - Chronophin - Bos taurus (Bovine) - PDXP gene Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism (By similarity). Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (PubMed:15580268). Indicus|evm.model.CM009495.1.1037 P11116 LEG1_BOVIN 100.000 0.985294 1.00741 LGALS1 - Galectin-1 - Bos taurus (Bovine) - LGALS1 gene Lectin that binds beta-galactoside and a wide array of complex carbohydrates (PubMed:1900835, PubMed:8108426, PubMed:7773775). Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Indicus|evm.model.CM009495.1.1038 Q2KIV0 NOL12_BOVIN 99.065 0.0894207 11.1831 NOL12 - Nucleolar protein 12 - Bos taurus (Bovine) - NOL12 gene May bind to 28S rRNA. Indicus|evm.model.CM009495.1.1039 Q0IIJ2 H10_BOVIN 100.000 0.989744 1.00515 H1-0 - Histone H1.0 - Bos taurus (Bovine) - H1-0 gene Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division (By similarity). Indicus|evm.model.CM009495.1.1040 Q0P5L8 KBL_BOVIN 100.000 0.995238 1.00239 GCAT - 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor - Bos taurus (Bovine) - GCAT gene mitochondrion Indicus|evm.model.CM009495.1.1041 O60755 GALR3_HUMAN 96.689 0.833333 0.48913 GALR3 - Galanin receptor type 3 - Homo sapiens (Human) - GALR3 gene Receptor for the hormone galanin (PubMed:25691535). Receptor for the hormone spexin-1 (PubMed:24517231). Indicus|evm.model.CM009495.1.1042 Q1LZC5 ANR54_BOVIN 99.331 0.993333 1.00334 ANKRD54 - Ankyrin repeat domain-containing protein 54 - Bos taurus (Bovine) - ANKRD54 gene Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. Indicus|evm.model.CM009495.1.1043 Q3ZCK1 EIF3L_BOVIN 100.000 0.99646 1.00177 EIF3L - Eukaryotic translation initiation factor 3 subunit L - Bos taurus (Bovine) - EIF3L gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Indicus|evm.model.CM009495.1.1045 E1BBG2 MILK1_BOVIN 99.883 0.997661 1.00234 MICALL1 - MICAL-like protein 1 - Bos taurus (Bovine) - MICALL1 gene Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth (By similarity). Indicus|evm.model.CM009495.1.1046 Q9BZE7 EVG1_HUMAN 84.332 0.911392 1.09217 C22orf23 - UPF0193 protein EVG1 - Homo sapiens (Human) - C22orf23 gene Indicus|evm.model.CM009495.1.1047 Q5R592 RPAB2_PONAB 100.000 0.984375 1.00787 POLR2F - DNA-directed RNA polymerases I, II, and III subunit RPABC2 - Pongo abelii (Sumatran orangutan) - POLR2F gene DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). Indicus|evm.model.CM009495.1.1048 A5A763 SOX10_PIG 99.147 0.995745 1.00213 SOX10 - Transcription factor SOX-10 - Sus scrofa (Pig) - SOX10 gene Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). Indicus|evm.model.CM009495.1.1049 Q2T9M1 PICK1_BOVIN 99.281 0.995215 1.0024 PICK1 - PRKCA-binding protein - Bos taurus (Bovine) - PICK1 gene Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function (By similarity). Indicus|evm.model.CM009495.1.1050 O95907 MOT3_HUMAN 86.573 0.991968 0.988095 SLC16A8 - Monocarboxylate transporter 3 - Homo sapiens (Human) - SLC16A8 gene Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). Indicus|evm.model.CM009495.1.1051 E1BFE9 BI2L2_BOVIN 91.373 0.996473 1.07183 BAIAP2L2 - Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 - Bos taurus (Bovine) - BAIAP2L2 gene Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). Indicus|evm.model.CM009495.1.1052 P97819 PLPL9_MOUSE 88.848 0.900336 1.10657 Pla2g6 - 85/88 kDa calcium-independent phospholipase A2 - Mus musculus (Mouse) - Pla2g6 gene Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:18937505). Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position. Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content (By similarity). Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species. Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs) (PubMed:24648512). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle (PubMed:18937505). Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin (By similarity). Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis (By similarity). Targets membrane phospholipids to produce potent lipid signaling messengers. Generates lysophosphatidate (LPA, 1-acyl-glycerol-3-phosphate), which acts via G-protein receptors in various cell types. Has phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent proinflammatory signaling lipid (By similarity). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion (PubMed:17895289). Indicus|evm.model.CM009495.1.1053 A7YY73 MAFF_BOVIN 100.000 0.745665 1.00581 MAFF - Transcription factor MafF - Bos taurus (Bovine) - MAFF gene Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Indicus|evm.model.CM009495.1.1054 A2VDL9 T184B_BOVIN 100.000 0.995098 1.00246 TMEM184B - Transmembrane protein 184B - Bos taurus (Bovine) - TMEM184B gene May activate the MAP kinase signaling pathway. Indicus|evm.model.CM009495.1.1055 P49674 KC1E_HUMAN 98.592 0.990654 0.514423 CSNK1E - Casein kinase I isoform epsilon - Homo sapiens (Human) - CSNK1E gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. Indicus|evm.model.CM009495.1.1056 Q9JMK2 KC1E_MOUSE 100.000 0.903382 0.497596 Csnk1e - Casein kinase I isoform epsilon - Mus musculus (Mouse) - Csnk1e gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. Indicus|evm.model.CM009495.1.1057 P52190 KCNJ4_RAT 100.000 0.531469 0.320628 Kcnj4 - Inward rectifier potassium channel 4 - Rattus norvegicus (Rat) - Kcnj4 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). Indicus|evm.model.CM009495.1.1058 O43731 ERD23_HUMAN 96.729 0.990698 1.00467 KDELR3 - ER lumen protein-retaining receptor 3 - Homo sapiens (Human) - KDELR3 gene Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. Indicus|evm.model.CM009495.1.1059 Q92841 DDX17_HUMAN 99.387 0.996937 0.895748 DDX17 - Probable ATP-dependent RNA helicase DDX17 - Homo sapiens (Human) - DDX17 gene As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). Indicus|evm.model.CM009495.1.1060 Q14565 DMC1_HUMAN 98.824 0.994135 1.00294 DMC1 - Meiotic recombination protein DMC1/LIM15 homolog - Homo sapiens (Human) - DMC1 gene Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Indicus|evm.model.CM009495.1.1061 F5H4B4 F227A_HUMAN 64.738 0.925424 1.03509 FAM227A - Protein FAM227A - Homo sapiens (Human) - FAM227A gene Indicus|evm.model.CM009495.1.1063 Q8MJK1 CBY1_BOVIN 100.000 0.984375 1.00787 CBY1 - Protein chibby homolog 1 - Bos taurus (Bovine) - CBY1 gene Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Indicus|evm.model.CM009495.1.1064 A6QPI6 TOM22_BOVIN 100.000 0.985816 1.00714 TOMM22 - Mitochondrial import receptor subunit TOM22 homolog - Bos taurus (Bovine) - TOMM22 gene Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity). Indicus|evm.model.CM009495.1.1065 Q5EAE5 JOS1_BOVIN 100.000 0.990148 1.00495 JOSD1 - Josephin-1 - Bos taurus (Bovine) - JOSD1 gene Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity). Indicus|evm.model.CM009495.1.1066 Q58DC5 GTPB1_BOVIN 99.851 0.997015 1.00149 GTPBP1 - GTP-binding protein 1 - Bos taurus (Bovine) - GTPBP1 gene Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). Indicus|evm.model.CM009495.1.1067 Q9UH99 SUN2_HUMAN 83.516 0.903106 1.12273 SUN2 - SUN domain-containing protein 2 - Homo sapiens (Human) - SUN2 gene As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. Indicus|evm.model.CM009495.1.1068 A4F4L4 DNAL4_PIG 98.113 0.452174 1.09524 DNAL4 - Dynein axonemal light chain 4 - Sus scrofa (Pig) - DNAL4 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). Indicus|evm.model.CM009495.1.1069 O95502 NPTXR_HUMAN 93.643 0.973558 0.832 NPTXR - Neuronal pentraxin receptor - Homo sapiens (Human) - NPTXR gene May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Indicus|evm.model.CM009495.1.1070 O95503 CBX6_HUMAN 90.886 0.834746 1.14563 CBX6 - Chromobox protein homolog 6 - Homo sapiens (Human) - CBX6 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). Indicus|evm.model.CM009495.1.1071 Q7YR24 ABC3G_PANTR 51.813 0.816594 0.596354 APOBEC3G - DNA dC->dU-editing enzyme APOBEC-3G - Pan troglodytes (Chimpanzee) - APOBEC3G gene DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient: HIV-1 and simian immunodeficiency viruses (SIVs) and also against simian foamy virus (SFV). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. May inhibit the mobility of LTR retrotransposons. Indicus|evm.model.CM009495.1.1072 P00423 COX41_BOVIN 86.310 0.981818 0.976331 COX4I1 - Cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor - Bos taurus (Bovine) - COX4I1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009495.1.1073 P60704 ABEC3_CRILO 44.413 0.888601 0.974747 APOBEC3 - DNA dC->dU-editing enzyme APOBEC3 - Cricetulus longicaudatus (Long-tailed dwarf hamster) - APOBEC3 gene DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Indicus|evm.model.CM009495.1.1074 P60889 CBX7_RAT 88.571 0.92053 0.955696 Cbx7 - Chromobox protein homolog 7 - Rattus norvegicus (Rat) - Cbx7 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded and double-stranded RNA. Plays a role in the timely repression of differentiation-specific genes in pluripotent embryonic stem cells to maintain the undifferentiated state. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity (By similarity). Indicus|evm.model.CM009495.1.1075 Q95229 PDGFB_SHEEP 97.521 0.991736 1.00415 PDGFB - Platelet-derived growth factor subunit B precursor - Ovis aries (Sheep) - PDGFB gene Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). Indicus|evm.model.CM009495.1.1076 P39872 RL3_BOVIN 100.000 0.923963 1.07692 RPL3 - 60S ribosomal protein L3 - Bos taurus (Bovine) - RPL3 gene The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Indicus|evm.model.CM009495.1.1079 Q62876 SNG1_RAT 93.590 0.991489 1.00427 Syngr1 - Synaptogyrin-1 - Rattus norvegicus (Rat) - Syngr1 gene May play a role in regulated exocytosis (PubMed:10383386). Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (PubMed:15590695, PubMed:12928441). Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). Indicus|evm.model.CM009495.1.1080 Q15750 TAB1_HUMAN 97.421 0.99604 1.00198 TAB1 - TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 - Homo sapiens (Human) - TAB1 gene May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Indicus|evm.model.CM009495.1.1081 L0R8F8 MIDUO_HUMAN 90.000 0.119584 8.24286 MIEF1 - MIEF1 upstream open reading frame protein - Homo sapiens (Human) - MIEF1 gene Involved in the regulation of mitochondrial fission mediated by DNM1L (PubMed:29083303). Positively regulates mitochondrial translation (PubMed:30215512). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Indicus|evm.model.CM009495.1.1082 Q8BGV8 MID51_MOUSE 96.760 0.99569 1.00216 Mief1 - Mitochondrial dynamics protein MID51 - Mus musculus (Mouse) - Mief1 gene Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. Indicus|evm.model.CM009495.1.1083 Q3ZCH6 ATF4_BOVIN 99.713 0.994269 1.00287 ATF4 - Cyclic AMP-dependent transcription factor ATF-4 - Bos taurus (Bovine) - ATF4 gene Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (By similarity). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress. During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (By similarity). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress. Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress. However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (By similarity). Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (By similarity). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress. May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (By similarity). In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (By similarity). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (By similarity). Indicus|evm.model.CM009495.1.1084 A6H7J2 AROS_BOVIN 100.000 0.985507 1.0073 RPS19BP1 - Active regulator of SIRT1 - Bos taurus (Bovine) - RPS19BP1 gene Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (By similarity). Indicus|evm.model.CM009495.1.1086 Q9P0X4 CAC1I_HUMAN 92.324 0.991076 0.85695 CACNA1I - Voltage-dependent T-type calcium channel subunit alpha-1I - Homo sapiens (Human) - CACNA1I gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity). Indicus|evm.model.CM009495.1.1087 Q8IYW4 ENTD1_HUMAN 69.885 0.996727 1.00659 ENTHD1 - ENTH domain-containing protein 1 - Homo sapiens (Human) - ENTHD1 gene clathrin vesicle coat, endosome, intracellular membrane-bounded organelle, plasma membrane, clathrin binding, phospholipid binding, endocytosis Indicus|evm.model.CM009495.1.1088 O75791 GRAP2_HUMAN 82.121 0.993691 0.960606 GRAP2 - GRB2-related adapter protein 2 - Homo sapiens (Human) - GRAP2 gene Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. Indicus|evm.model.CM009495.1.1089 Q8NEG4 FA83F_HUMAN 71.992 0.995565 0.902 FAM83F - Protein FAM83F - Homo sapiens (Human) - FAM83F gene protein kinase binding, signal transduction Indicus|evm.model.CM009495.1.1090 Q8BKI2 TNR6B_MOUSE 94.015 0.992693 0.982873 Tnrc6b - Trinucleotide repeat-containing gene 6B protein - Mus musculus (Mouse) - Tnrc6b gene Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Indicus|evm.model.CM009495.1.1091 A3KN12 PUR8_BOVIN 99.388 0.995927 1.00204 ADSL - Adenylosuccinate lyase - Bos taurus (Bovine) - ADSL gene Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. Indicus|evm.model.CM009495.1.1092 Q2KI13 SGSM3_BOVIN 99.732 0.997326 1.00134 SGSM3 - Small G protein signaling modulator 3 - Bos taurus (Bovine) - SGSM3 gene May play a cooperative role in NF2-mediated growth suppression of cells. Indicus|evm.model.CM009495.1.1093 Q8K4J6 MRTFA_MOUSE 81.138 0.529364 1.28942 Mrtfa - Myocardin-related transcription factor A - Mus musculus (Mouse) - Mrtfa gene Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12019265, PubMed:12732141, PubMed:17588931, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex (PubMed:12732141, PubMed:17588931). Activity is also regulated by filamentous actin (F-actin) in the nucleus (PubMed:23558171, PubMed:25759381). Indicus|evm.model.CM009495.1.1094 Q9MZ01 MCHR1_PIG 97.521 0.338983 2.92562 MCHR1 - Melanin-concentrating hormone receptor 1 - Sus scrofa (Pig) - MCHR1 gene Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Indicus|evm.model.CM009495.1.1095 O43808 PM34_HUMAN 94.788 0.993506 1.00326 SLC25A17 - Peroxisomal membrane protein PMP34 - Homo sapiens (Human) - SLC25A17 gene Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro. Indicus|evm.model.CM009495.1.1096 P50502 F10A1_HUMAN 95.122 0.994595 1.00271 ST13 - Hsc70-interacting protein - Homo sapiens (Human) - ST13 gene One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). Indicus|evm.model.CM009495.1.1097 Q5R9W8 XPP3_PONAB 89.941 0.996063 1.00197 XPNPEP3 - Xaa-Pro aminopeptidase 3 precursor - Pongo abelii (Sumatran orangutan) - XPNPEP3 gene Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling. Indicus|evm.model.CM009495.1.1098 P62878 RBX1_MOUSE 100.000 0.981651 1.00926 Rbx1 - E3 ubiquitin-protein ligase RBX1 - Mus musculus (Mouse) - Rbx1 gene E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:22118460). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components (By similarity). As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate (By similarity). Probably also stimulates CDC34 autoubiquitination (By similarity). May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair (By similarity). Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity). Indicus|evm.model.CM009495.1.1100 Q09472 EP300_HUMAN 94.548 0.999171 0.999171 EP300 - Histone acetyltransferase p300 - Homo sapiens (Human) - EP300 gene Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degragation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Indicus|evm.model.CM009495.1.1101 Q1JQD9 LMBL2_BOVIN 100.000 0.997171 1.00142 L3MBTL2 - Lethal(3)malignant brain tumor-like protein 2 - Bos taurus (Bovine) - L3MBTL2 gene Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). Indicus|evm.model.CM009495.1.1102 E9Q7T7 CHADL_MOUSE 88.664 0.349929 0.93984 Chadl - Chondroadherin-like protein precursor - Mus musculus (Mouse) - Chadl gene Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment. Indicus|evm.model.CM009495.1.1103 P46060 RAGP1_HUMAN 90.290 0.93131 1.06644 RANGAP1 - Ran GTPase-activating protein 1 - Homo sapiens (Human) - RANGAP1 gene GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). Indicus|evm.model.CM009495.1.1104 Q9UGR2 Z3H7B_HUMAN 96.559 0.940137 1.04299 ZC3H7B - Zinc finger CCCH domain-containing protein 7B - Homo sapiens (Human) - ZC3H7B gene May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop. Indicus|evm.model.CM009495.1.1106 P97516 TEF_PHOSU 98.190 0.768421 1.28959 TEF - Thyrotroph embryonic factor - Phodopus sungorus (Striped hairy-footed hamster) - TEF gene Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3' (By similarity). Indicus|evm.model.CM009495.1.1107 Q14106 TOB2_HUMAN 94.493 0.99422 1.00581 TOB2 - Protein Tob2 - Homo sapiens (Human) - TOB2 gene Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases. Indicus|evm.model.CM009495.1.1108 P83871 PHF5A_RAT 100.000 0.981982 1.00909 Phf5a - PHD finger-like domain-containing protein 5A - Rattus norvegicus (Rat) - Phf5a gene Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes. Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies. Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (PubMed:12810571). Indicus|evm.model.CM009495.1.1109 P20004 ACON_BOVIN 100.000 0.997439 1.00128 ACO2 - Aconitate hydratase, mitochondrial precursor - Bos taurus (Bovine) - ACO2 gene Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Indicus|evm.model.CM009495.1.1110 Q2T9X1 RPC8_BOVIN 99.020 0.990244 1.0049 POLR3H - DNA-directed RNA polymerase III subunit RPC8 - Bos taurus (Bovine) - POLR3H gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Indicus|evm.model.CM009495.1.1111 Q9Y534 CSDC2_HUMAN 94.771 0.987013 1.00654 CSDC2 - Cold shock domain-containing protein C2 - Homo sapiens (Human) - CSDC2 gene RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). Indicus|evm.model.CM009495.1.1112 Q92871 PMM1_HUMAN 96.183 0.992395 1.00382 PMM1 - Phosphomannomutase 1 - Homo sapiens (Human) - PMM1 gene Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. Indicus|evm.model.CM009495.1.1113 O02751 CFDP2_BOVIN 81.111 0.98895 0.305743 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Indicus|evm.model.CM009495.1.1114 Q6ICB0 DESI1_HUMAN 95.238 0.988166 1.00595 DESI1 - Desumoylating isopeptidase 1 - Homo sapiens (Human) - DESI1 gene Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Indicus|evm.model.CM009495.1.1115 P12956 XRCC6_HUMAN 84.375 0.993421 0.998358 XRCC6 - X-ray repair cross-complementing protein 6 - Homo sapiens (Human) - XRCC6 gene Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009495.1.1116 P55770 NH2L1_RAT 100.000 0.984496 1.00781 Snu13 - NHP2-like protein 1 - Rattus norvegicus (Rat) - Snu13 gene Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Indicus|evm.model.CM009495.1.1117 C9J442 CV046_HUMAN 64.372 0.15409 6.48971 C22orf46 - Uncharacterized protein C22orf46 precursor - Homo sapiens (Human) - C22orf46 gene Indicus|evm.model.CM009495.1.1118 A8D8X1 RL10_SHEEP 99.038 0.0769806 6.25234 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009495.1.1119 Q9H6E4 CC134_HUMAN 93.458 0.628319 1.48035 CCDC134 - Coiled-coil domain-containing protein 134 precursor - Homo sapiens (Human) - CCDC134 gene In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). Indicus|evm.model.CM009495.1.1120 Q12772 SRBP2_HUMAN 88.040 0.949911 0.979842 SREBF2 - Sterol regulatory element-binding protein 2 - Homo sapiens (Human) - SREBF2 gene Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). Indicus|evm.model.CM009495.1.1121 J3QNX5 SHSA8_MOUSE 75.893 0.822878 0.679198 Shisa8 - Protein shisa-8 precursor - Mus musculus (Mouse) - Shisa8 gene May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses. Indicus|evm.model.CM009495.1.1122 Q96RJ3 TR13C_HUMAN 64.634 0.493902 0.891304 TNFRSF13C - Tumor necrosis factor receptor superfamily member 13C - Homo sapiens (Human) - TNFRSF13C gene B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Indicus|evm.model.CM009495.1.1123 Q2TBH1 CENPM_BOVIN 100.000 0.98895 1.00556 CENPM - Centromere protein M - Bos taurus (Bovine) - CENPM gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Indicus|evm.model.CM009495.1.1125 Q08DM7 SEPT3_BOVIN 99.440 0.426859 2.33613 SEPTIN3 - Neuronal-specific septin-3 - Bos taurus (Bovine) - SEPTIN3 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Indicus|evm.model.CM009495.1.1126 A3KFF6 WBP2L_BOVIN 98.722 0.993631 1.00319 WBP2NL - Postacrosomal sheath WW domain-binding protein - Bos taurus (Bovine) - WBP2NL gene May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization. Indicus|evm.model.CM009495.1.1127 Q58DH9 NAGAB_BOVIN 99.270 0.995146 1.00243 NAGA - Alpha-N-acetylgalactosaminidase precursor - Bos taurus (Bovine) - NAGA gene Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids. Indicus|evm.model.CM009495.1.1128 Q1RMU7 SESQ2_BOVIN 99.228 0.980989 1.01544 PHETA2 - Sesquipedalian-2 - Bos taurus (Bovine) - PHETA2 gene Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. Indicus|evm.model.CM009495.1.1129 Q2M2S2 EMRE_BOVIN 100.000 0.981481 1.00935 SMDT1 - Essential MCU regulator, mitochondrial precursor - Bos taurus (Bovine) - SMDT1 gene Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling. Indicus|evm.model.CM009495.1.1130 Q02366 NDUA6_BOVIN 100.000 0.819355 1.21094 NDUFA6 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 - Bos taurus (Bovine) - NDUFA6 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009495.1.1132 Q01361 CP2DE_BOVIN 84.600 0.995565 0.902 CYP2D14 - Cytochrome P450 2D14 - Bos taurus (Bovine) - CYP2D14 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Indicus|evm.model.CM009495.1.1134 Q01361 CP2DE_BOVIN 99.600 0.996008 1.002 CYP2D14 - Cytochrome P450 2D14 - Bos taurus (Bovine) - CYP2D14 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Indicus|evm.model.CM009495.1.1136 Q9UGU0 TCF20_HUMAN 91.878 0.978109 1.02551 TCF20 - Transcription factor 20 - Homo sapiens (Human) - TCF20 gene Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. Indicus|evm.model.CM009495.1.1137 Q8NET5 NFAM1_HUMAN 63.801 0.669725 1.21111 NFAM1 - NFAT activation molecule 1 precursor - Homo sapiens (Human) - NFAM1 gene May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. Indicus|evm.model.CM009495.1.1138 Q9NQF3 SERHL_HUMAN 80.117 0.433673 1.93103 SERHL - Serine hydrolase-like protein - Homo sapiens (Human) - SERHL gene Putative serine hydrolase. Indicus|evm.model.CM009495.1.1139 Q9NSQ0 RRP7B_HUMAN 92.308 0.366548 2.72816 RRP7BP - Putative ribosomal RNA-processing protein 7 homolog B - Homo sapiens (Human) - RRP7BP gene CURI complex, UTP-C complex, ribosomal small subunit assembly, rRNA processing Indicus|evm.model.CM009495.1.1140 Q9BY77 PDIP3_HUMAN 94.774 0.995261 1.00238 POLDIP3 - Polymerase delta-interacting protein 3 - Homo sapiens (Human) - POLDIP3 gene Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. Indicus|evm.model.CM009495.1.1141 P07514 NB5R3_BOVIN 100.000 0.992832 0.92691 CYB5R3 - NADH-cytochrome b5 reductase 3 - Bos taurus (Bovine) - CYB5R3 gene Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Indicus|evm.model.CM009495.1.1142 Q9N289 A4GAT_PONPY 90.826 0.609551 1.63303 A4GALT - Lactosylceramide 4-alpha-galactosyltransferase - Pongo pygmaeus (Bornean orangutan) - A4GALT gene Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1 Indicus|evm.model.CM009495.1.1143 P24049 RL17_RAT 92.727 0.863158 1.03261 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009495.1.1144 Q17R07 ARFG3_BOVIN 99.807 0.996139 1.00193 ARFGAP3 - ADP-ribosylation factor GTPase-activating protein 3 - Bos taurus (Bovine) - ARFGAP3 gene GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1) (PubMed:1910037). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). Indicus|evm.model.CM009495.1.1145 Q5RDT5 SAP18_PONAB 88.889 0.986928 1 SAP18 - Histone deacetylase complex subunit SAP18 - Pongo abelii (Sumatran orangutan) - SAP18 gene Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function (By similarity). Indicus|evm.model.CM009495.1.1146 Q9WVE8 PACN2_MOUSE 91.152 0.995893 1.00206 Pacsin2 - Protein kinase C and casein kinase substrate in neurons protein 2 - Mus musculus (Mouse) - Pacsin2 gene Regulates the morphogenesis and endocytosis of caveolae (PubMed:21807942). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Indicus|evm.model.CM009495.1.1147 Q0VC71 TTLL1_BOVIN 100.000 0.995283 1.00236 TTLL1 - Probable tubulin polyglutamylase TTLL1 - Bos taurus (Bovine) - TTLL1 gene Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity). Indicus|evm.model.CM009495.1.1149 Q8IVS2 FABD_HUMAN 80.612 0.992268 0.994872 MCAT - Malonyl-CoA-acyl carrier protein transacylase, mitochondrial precursor - Homo sapiens (Human) - MCAT gene Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria. Indicus|evm.model.CM009495.1.1150 P30535 TSPO_BOVIN 98.817 0.988235 1.00592 TSPO - Translocator protein - Bos taurus (Bovine) - TSPO gene Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1649835). Indicus|evm.model.CM009495.1.1151 Q14166 TTL12_HUMAN 85.191 0.996951 1.01863 TTLL12 - Tubulin--tyrosine ligase-like protein 12 - Homo sapiens (Human) - TTLL12 gene Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935). Indicus|evm.model.CM009495.1.1152 Q6NZL8 SCUB1_MOUSE 89.958 0.831882 1.1277 Scube1 - Signal peptide, CUB and EGF-like domain-containing protein 1 precursor - Mus musculus (Mouse) - Scube1 gene Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. Indicus|evm.model.CM009495.1.1153 O15442 MPPD1_HUMAN 98.578 0.990566 0.650307 MPPED1 - Metallophosphoesterase domain-containing protein 1 - Homo sapiens (Human) - MPPED1 gene May have metallophosphoesterase activity (in vitro). Indicus|evm.model.CM009495.1.1154 Q2HJ55 SAM50_BOVIN 93.750 0.873585 1.13006 SAMM50 - Sorting and assembly machinery component 50 homolog - Bos taurus (Bovine) - SAMM50 gene Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex. Indicus|evm.model.CM009495.1.1155 Q9NST1 PLPL3_HUMAN 55.990 0.808791 0.945946 PNPLA3 - 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 - Homo sapiens (Human) - PNPLA3 gene Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221). Has hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (PubMed:21878620). Indicus|evm.model.CM009495.1.1157 Q9NST1 PLPL3_HUMAN 58.108 0.821012 1.06861 PNPLA3 - 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 - Homo sapiens (Human) - PNPLA3 gene Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221). Has hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (PubMed:21878620). Indicus|evm.model.CM009495.1.1158 Q9BR01 ST4A1_HUMAN 85.774 0.412698 1.77465 SULT4A1 - Sulfotransferase 4A1 - Homo sapiens (Human) - SULT4A1 gene Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. Indicus|evm.model.CM009495.1.1159 Q4R8T1 EFCB6_MACFA 77.709 0.475204 2.09133 EFCAB6 - EF-hand calcium-binding domain-containing protein 6 - Macaca fascicularis (Crab-eating macaque) - EFCAB6 gene Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. Indicus|evm.model.CM009495.1.1160 O15442 MPPD1_HUMAN 98.701 0.72381 0.322086 MPPED1 - Metallophosphoesterase domain-containing protein 1 - Homo sapiens (Human) - MPPED1 gene May have metallophosphoesterase activity (in vitro). Indicus|evm.model.CM009495.1.1162 Q9HBI1 PARVB_HUMAN 91.437 0.953216 0.93956 PARVB - Beta-parvin - Homo sapiens (Human) - PARVB gene Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. Indicus|evm.model.CM009495.1.1163 Q9HBI0 PARVG_HUMAN 81.873 0.962099 1.03625 PARVG - Gamma-parvin - Homo sapiens (Human) - PARVG gene Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Indicus|evm.model.CM009495.1.1164 Q3SXP7 SHSL1_HUMAN 94.975 0.985 1.00503 SHISAL1 - Protein shisa-like-1 precursor - Homo sapiens (Human) - SHISAL1 gene Indicus|evm.model.CM009495.1.1165 Q6ICC9 RTL6_HUMAN 94.561 0.991667 1.00418 RTL6 - Retrotransposon Gag-like protein 6 - Homo sapiens (Human) - RTL6 gene Indicus|evm.model.CM009495.1.1166 P85299 PRR5_HUMAN 94.215 0.845614 0.734536 PRR5 - Proline-rich protein 5 - Homo sapiens (Human) - PRR5 gene Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. Indicus|evm.model.CM009495.1.1167 Q9CXP4 RHG08_MOUSE 79.759 0.8625 1.12941 Arhgap8 - Rho GTPase-activating protein 8 - Mus musculus (Mouse) - Arhgap8 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009495.1.1168 Q8C966 PF21B_MOUSE 86.122 0.995918 1.00616 Phf21b - PHD finger protein 21B - Mus musculus (Mouse) - Phf21b gene Indicus|evm.model.CM009495.1.1171 Q9UKX7 NUP50_HUMAN 84.894 0.995708 0.995726 NUP50 - Nuclear pore complex protein Nup50 - Homo sapiens (Human) - NUP50 gene Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). Indicus|evm.model.CM009495.1.1172 Q6ICG6 K0930_HUMAN 94.724 0.9274 1.05693 KIAA0930 - Uncharacterized protein KIAA0930 - Homo sapiens (Human) - KIAA0930 gene Indicus|evm.model.CM009495.1.1173 P38574 UPK3A_BOVIN 100.000 0.993056 1.00348 UPK3A - Uroplakin-3a precursor - Bos taurus (Bovine) - UPK3A gene Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence. Indicus|evm.model.CM009495.1.1174 Q91YN1 F118A_MOUSE 94.118 0.994413 1.0028 Fam118a - Protein FAM118A - Mus musculus (Mouse) - Fam118a gene identical protein binding Indicus|evm.model.CM009495.1.1175 Q8NDV3 SMC1B_HUMAN 88.537 0.994337 1.00081 SMC1B - Structural maintenance of chromosomes protein 1B - Homo sapiens (Human) - SMC1B gene Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). Indicus|evm.model.CM009495.1.1176 Q32LJ7 RIBC2_BOVIN 99.469 0.994709 1.00265 RIBC2 - RIB43A-like with coiled-coils protein 2 - Bos taurus (Bovine) - RIBC2 gene Indicus|evm.model.CM009495.1.1177 Q8MJJ9 FBLN1_CHLAE 88.060 0.874818 1.14883 FBLN1 - Fibulin-1 - Chlorocebus aethiops (Green monkey) - FBLN1 gene Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. May serve to anchor the mature/soluble form of DTR to its fibers as it migrates through the extracellular matrix. The direct physical association with DTR may be useful in such tissue developmental processes as wound healing. Indicus|evm.model.CM009495.1.1178 P23142 FBLN1_HUMAN 91.971 0.918919 0.210526 FBLN1 - Fibulin-1 precursor - Homo sapiens (Human) - FBLN1 gene Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. Indicus|evm.model.CM009495.1.1180 Q2TBW0 ATX10_BOVIN 99.789 0.711712 1.40211 ATXN10 - Ataxin-10 - Bos taurus (Bovine) - ATXN10 gene Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. Indicus|evm.model.CM009495.1.1181 P28047 WNT7B_MOUSE 97.656 0.947566 0.765043 Wnt7b - Protein Wnt-7b precursor - Mus musculus (Mouse) - Wnt7b gene Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619, PubMed:28803732). Required for normal fusion of the chorion and the allantois during placenta development (PubMed:11543617). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:28803732). Indicus|evm.model.CM009495.1.1182 P56706 WNT7B_HUMAN 96.154 0.466667 0.472779 WNT7B - Protein Wnt-7b precursor - Homo sapiens (Human) - WNT7B gene Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Indicus|evm.model.CM009495.1.1186 Q95N78 PPARA_CANLF 95.299 0.63365 1.57479 PPARA - Peroxisome proliferator-activated receptor alpha - Canis lupus familiaris (Dog) - PPARA gene Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity). Indicus|evm.model.CM009495.1.1187 Q0VCH3 CDPF1_BOVIN 100.000 0.764331 1.29752 CDPF1 - Cysteine-rich DPF motif domain-containing protein 1 - Bos taurus (Bovine) - CDPF1 gene Indicus|evm.model.CM009495.1.1188 Q9NTG1 PKDRE_HUMAN 66.521 0.998542 0.608966 PKDREJ - Polycystic kidney disease and receptor for egg jelly-related protein precursor - Homo sapiens (Human) - PKDREJ gene May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm. Indicus|evm.model.CM009495.1.1189 Q5RFF7 TTC38_PONAB 83.582 0.995671 0.985075 TTC38 - Tetratricopeptide repeat protein 38 - Pongo abelii (Sumatran orangutan) - TTC38 gene Indicus|evm.model.CM009495.1.1190 Q9NYZ3 GTSE1_HUMAN 65.753 0.571053 0.527778 GTSE1 - G2 and S phase-expressed protein 1 - Homo sapiens (Human) - GTSE1 gene May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. Indicus|evm.model.CM009495.1.1191 Q9NTG1 PKDRE_HUMAN 63.561 0.995828 0.95739 PKDREJ - Polycystic kidney disease and receptor for egg jelly-related protein precursor - Homo sapiens (Human) - PKDREJ gene May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm. Indicus|evm.model.CM009495.1.1192 Q9NTG1 PKDRE_HUMAN 64.380 0.998538 0.910786 PKDREJ - Polycystic kidney disease and receptor for egg jelly-related protein precursor - Homo sapiens (Human) - PKDREJ gene May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm. Indicus|evm.model.CM009495.1.1193 Q9NYZ3 GTSE1_HUMAN 57.438 0.993763 0.668056 GTSE1 - G2 and S phase-expressed protein 1 - Homo sapiens (Human) - GTSE1 gene May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. Indicus|evm.model.CM009495.1.1194 O75648 MTU1_HUMAN 90.385 0.992823 0.992874 TRMU - Mitochondrial tRNA-specific 2-thiouridylase 1 - Homo sapiens (Human) - TRMU gene Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. Indicus|evm.model.CM009495.1.1195 O35161 CELR1_MOUSE 76.110 0.968835 0.602835 Celsr1 - Cadherin EGF LAG seven-pass G-type receptor 1 precursor - Mus musculus (Mouse) - Celsr1 gene Receptor that may have an important role in cell/cell signaling during nervous system formation. Indicus|evm.model.CM009495.1.1196 O35161 CELR1_MOUSE 94.993 0.542296 0.436388 Celsr1 - Cadherin EGF LAG seven-pass G-type receptor 1 precursor - Mus musculus (Mouse) - Celsr1 gene Receptor that may have an important role in cell/cell signaling during nervous system formation. Indicus|evm.model.CM009495.1.1198 Q6IC98 GRAM4_HUMAN 93.253 0.93517 1.06747 GRAMD4 - GRAM domain-containing protein 4 - Homo sapiens (Human) - GRAMD4 gene Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity). Indicus|evm.model.CM009495.1.1199 Q8TCT0 CERK1_HUMAN 77.234 0.924901 0.942272 CERK - Ceramide kinase - Homo sapiens (Human) - CERK gene Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031). Indicus|evm.model.CM009495.1.1200 Q95KI1 TB22A_MACFA 85.513 0.828859 1.1992 TBC1D22A - TBC1 domain family member 22A - Macaca fascicularis (Crab-eating macaque) - TBC1D22A gene May act as a GTPase-activating protein for Rab family protein(s). Indicus|evm.model.CM009495.1.1216 M0R7X9 TAFA5_RAT 98.039 0.247525 1.5303 Tafa5 - Chemokine-like protein TAFA-5 precursor - Rattus norvegicus (Rat) - Tafa5 gene Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (PubMed:29453251). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (By similarity). Acts as a adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (PubMed:29453251). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (PubMed:29453251). Indicus|evm.model.CM009495.1.1220 Q9BVL4 SELO_HUMAN 80.292 0.680851 1.19432 SELENOO - Protein adenylyltransferase SelO, mitochondrial precursor - Homo sapiens (Human) - SELENOO gene Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation) (PubMed:30270044). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein (PubMed:24751718). Indicus|evm.model.CM009495.1.1221 Q96RT7 GCP6_HUMAN 73.037 0.684466 0.905992 TUBGCP6 - Gamma-tubulin complex component 6 - Homo sapiens (Human) - TUBGCP6 gene Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Indicus|evm.model.CM009495.1.1222 Q969S8 HDA10_HUMAN 78.829 0.989568 1.00299 HDAC10 - Polyamine deacetylase HDAC10 - Homo sapiens (Human) - HDAC10 gene Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). Indicus|evm.model.CM009495.1.1223 Q63538 MK12_RAT 92.916 0.994565 1.00272 Mapk12 - Mitogen-activated protein kinase 12 - Rattus norvegicus (Rat) - Mapk12 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. Indicus|evm.model.CM009495.1.1224 Q15759 MK11_HUMAN 96.875 0.992218 0.706044 MAPK11 - Mitogen-activated protein kinase 11 - Homo sapiens (Human) - MAPK11 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Indicus|evm.model.CM009495.1.1225 O15031 PLXB2_HUMAN 87.195 0.965915 1.03754 PLXNB2 - Plexin-B2 precursor - Homo sapiens (Human) - PLXNB2 gene Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458). Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888). May modulate the activity of RAC1 and CDC42 (By similarity). Indicus|evm.model.CM009495.1.1226 Q8NEG7 DEN6B_HUMAN 86.724 0.984563 0.996581 DENND6B - Protein DENND6B - Homo sapiens (Human) - DENND6B gene Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35. Indicus|evm.model.CM009495.1.1227 O75170 PP6R2_HUMAN 74.216 0.971564 0.873706 PPP6R2 - Serine/threonine-protein phosphatase 6 regulatory subunit 2 - Homo sapiens (Human) - PPP6R2 gene Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Indicus|evm.model.CM009495.1.1228 O95248 MTMR5_HUMAN 89.214 0.954252 0.994647 SBF1 - Myotubularin-related protein 5 - Homo sapiens (Human) - SBF1 gene Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location (PubMed:12668758). May function as a guanine nucleotide exchange factor (GEF) activating RAB28 (PubMed:20937701). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701). Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts (PubMed:9537414). Indicus|evm.model.CM009495.1.1229 Q7Z4H4 ADM2_HUMAN 67.568 0.986014 0.966216 ADM2 - Protein ADM2 precursor - Homo sapiens (Human) - ADM2 gene May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. Indicus|evm.model.CM009495.1.1230 A7MBE4 MIOX_BOVIN 100.000 0.815126 0.835088 MIOX - Inositol oxygenase - Bos taurus (Bovine) - MIOX gene ferric iron binding, inositol oxygenase activity, inositol catabolic process Indicus|evm.model.CM009495.1.1231 A7MBE4 MIOX_BOVIN 100.000 0.40566 0.37193 MIOX - Inositol oxygenase - Bos taurus (Bovine) - MIOX gene ferric iron binding, inositol oxygenase activity, inositol catabolic process Indicus|evm.model.CM009495.1.1232 A1L504 LMF2_BOVIN 99.851 0.989676 0.964438 LMF2 - Lipase maturation factor 2 - Bos taurus (Bovine) - LMF2 gene Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity). Indicus|evm.model.CM009495.1.1233 Q3SZL8 CNDH2_BOVIN 100.000 0.962171 0.977492 NCAPH2 - Condensin-2 complex subunit H2 - Bos taurus (Bovine) - NCAPH2 gene Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (By similarity). Indicus|evm.model.CM009495.1.1234 A6H784 SCO2_BOVIN 100.000 0.923345 1.07895 SCO2 - Protein SCO2 homolog, mitochondrial precursor - Bos taurus (Bovine) - SCO2 gene Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2. Indicus|evm.model.CM009495.1.1235 A8MYP8 ODF3B_HUMAN 81.746 0.943609 1.05138 ODF3B - Outer dense fiber protein 3B - Homo sapiens (Human) - ODF3B gene cytoskeleton Indicus|evm.model.CM009495.1.1236 Q96G42 KLD7B_HUMAN 68.977 0.51086 1.93771 KLHDC7B - Kelch domain-containing protein 7B - Homo sapiens (Human) - KLHDC7B gene Indicus|evm.model.CM009495.1.1237 B5KM66 SYCE3_MOUSE 90.909 0.945652 1.04545 Syce3 - Synaptonemal complex central element protein 3 - Mus musculus (Mouse) - Syce3 gene Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism. Indicus|evm.model.CM009495.1.1238 Q58DK1 CPT1B_BOVIN 100.000 0.997409 1.0013 CPT1B - Carnitine O-palmitoyltransferase 1, muscle isoform - Bos taurus (Bovine) - CPT1B gene mitochondrion, carnitine O-palmitoyltransferase activity, carnitine metabolic process, fatty acid metabolic process, long-chain fatty acid transport, response to blue light Indicus|evm.model.CM009495.1.1239 Q9Y259 CHKB_HUMAN 88.354 0.994949 1.00253 CHKB - Choline/ethanolamine kinase - Homo sapiens (Human) - CHKB gene Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis. Indicus|evm.model.CM009495.1.1240 Q13387 JIP2_HUMAN 93.132 0.437956 0.997573 MAPK8IP2 - C-Jun-amino-terminal kinase-interacting protein 2 - Homo sapiens (Human) - MAPK8IP2 gene The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Indicus|evm.model.CM009495.1.1241 Q08DD1 ARSA_BOVIN 100.000 0.996063 1.00197 ARSA - Arylsulfatase A precursor - Bos taurus (Bovine) - ARSA gene Hydrolyzes cerebroside sulfate. Indicus|evm.model.CM009495.1.1242 Q4ACU6 SHAN3_MOUSE 93.411 0.271768 1.09538 Shank3 - SH3 and multiple ankyrin repeat domains protein 3 - Mus musculus (Mouse) - Shank3 gene Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. Indicus|evm.model.CM009495.1.1260 O95696 BRD1_HUMAN 93.015 0.223782 1.14461 BRD1 - Bromodomain-containing protein 1 - Homo sapiens (Human) - BRD1 gene Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). Indicus|evm.model.CM009495.1.1262 O75132 ZBED4_HUMAN 82.083 0.997226 0.615713 ZBED4 - Zinc finger BED domain-containing protein 4 - Homo sapiens (Human) - ZBED4 gene Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity). Indicus|evm.model.CM009495.1.1263 Q9BV10 ALG12_HUMAN 79.796 0.993902 1.0082 ALG12 - Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase - Homo sapiens (Human) - ALG12 gene Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Indicus|evm.model.CM009495.1.1265 Q2KIT5 CREL2_BOVIN 98.860 0.994318 1.00285 CRELD2 - Protein disulfide isomerase CRELD2 precursor - Bos taurus (Bovine) - CRELD2 gene Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity). Indicus|evm.model.CM009495.1.1266 P58750 PIM3_MOUSE 95.706 0.993884 1.00307 Pim3 - Serine/threonine-protein kinase pim-3 - Mus musculus (Mouse) - Pim3 gene Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. Indicus|evm.model.CM009495.1.1268 Q6ZVW7 I17EL_HUMAN 68.831 0.590998 1.52083 IL17REL - Putative interleukin-17 receptor E-like - Homo sapiens (Human) - IL17REL gene interleukin-17 receptor activity Indicus|evm.model.CM009495.1.1269 A4Q9F1 TTLL8_MOUSE 75.649 0.689342 0.530048 Ttll8 - Protein monoglycylase TTLL8 - Mus musculus (Mouse) - Ttll8 gene Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction. Indicus|evm.model.CM009495.1.1270 A6PVC2 TTLL8_HUMAN 84.314 0.434783 0.135294 TTLL8 - Protein monoglycylase TTLL8 - Homo sapiens (Human) - TTLL8 gene Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity). Indicus|evm.model.CM009495.1.1271 Q15049 MLC1_HUMAN 81.419 0.396226 1.96817 MLC1 - Membrane protein MLC1 - Homo sapiens (Human) - MLC1 gene Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. Indicus|evm.model.CM009495.1.1272 Q99MV5 M10L1_MOUSE 86.282 0.422785 0.998315 Mov10l1 - RNA helicase Mov10l1 - Mus musculus (Mouse) - Mov10l1 gene ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Involved in the primary piRNA metabolic process (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). Indicus|evm.model.CM009495.1.1273 Q96RD6 PANX2_HUMAN 81.832 0.96823 0.976366 PANX2 - Pannexin-2 - Homo sapiens (Human) - PANX2 gene Structural component of the gap junctions and the hemichannels. Indicus|evm.model.CM009495.1.1274 Q58DF3 TRABD_BOVIN 100.000 0.994709 1.00265 TRABD - TraB domain-containing protein - Bos taurus (Bovine) - TRABD gene Indicus|evm.model.CM009496.1.1 Q8NH69 OR5W2_HUMAN 74.699 0.97619 0.270968 OR5W2 - Olfactory receptor 5W2 - Homo sapiens (Human) - OR5W2 gene Odorant receptor. Indicus|evm.model.CM009496.1.2 O46414 FRIH_BOVIN 97.238 0.989011 1.00552 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009496.1.4 Q8TCQ1 MARH1_HUMAN 86.640 0.97619 0.871972 MARCHF1 - E3 ubiquitin-protein ligase MARCHF1 - Homo sapiens (Human) - MARCHF1 gene E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. Indicus|evm.model.CM009496.1.5 Q3T071 TMA16_BOVIN 99.507 0.990196 1.00493 TMA16 - Translation machinery-associated protein 16 - Bos taurus (Bovine) - TMA16 gene nucleus Indicus|evm.model.CM009496.1.6 Q2NKZ4 TKTL2_BOVIN 100.000 0.99681 1.0016 TKTL2 - Transketolase-like protein 2 - Bos taurus (Bovine) - TKTL2 gene Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity). Indicus|evm.model.CM009496.1.7 O62729 NPY5R_CANLF 91.256 0.995526 1.00224 NPY5R - Neuropeptide Y receptor type 5 - Canis lupus familiaris (Dog) - NPY5R gene Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity). Indicus|evm.model.CM009496.1.9 Q1RMU8 NPY1R_BOVIN 100.000 0.994792 1.00261 NPY1R - Neuropeptide Y receptor type 1 - Bos taurus (Bovine) - NPY1R gene Receptor for neuropeptide Y and peptide YY. Indicus|evm.model.CM009496.1.11 Q8IWZ6 BBS7_HUMAN 94.266 0.997207 1.0014 BBS7 - Bardet-Biedl syndrome 7 protein - Homo sapiens (Human) - BBS7 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Indicus|evm.model.CM009496.1.12 P30274 CCNA2_BOVIN 100.000 0.99536 1.00233 CCNA2 - Cyclin-A2 - Bos taurus (Bovine) - CCNA2 gene Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Indicus|evm.model.CM009496.1.13 Q3SWZ4 EXOS9_BOVIN 99.773 0.995465 1.00227 EXOSC9 - Exosome complex component RRP45 - Bos taurus (Bovine) - EXOSC9 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs (By similarity). Indicus|evm.model.CM009496.1.14 P81287 ANXA5_BOVIN 99.377 0.993789 1.00312 ANXA5 - Annexin A5 - Bos taurus (Bovine) - ANXA5 gene This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Indicus|evm.model.CM009496.1.15 P29562 IF4A1_RABIT 64.368 0.9875 0.201005 EIF4A1 - Eukaryotic initiation factor 4A-I - Oryctolagus cuniculus (Rabbit) - EIF4A1 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Indicus|evm.model.CM009496.1.16 Q5R5F5 IF4A1_PONAB 73.913 0.964602 0.278325 EIF4A1 - Eukaryotic initiation factor 4A-I - Pongo abelii (Sumatran orangutan) - EIF4A1 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Indicus|evm.model.CM009496.1.17 Q96P65 QRFPR_HUMAN 91.415 0.99537 1.00232 QRFPR - Pyroglutamylated RF-amide peptide receptor - Homo sapiens (Human) - QRFPR gene Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels. Indicus|evm.model.CM009496.1.18 Q8TB73 NDNF_HUMAN 93.465 0.963671 0.920775 NDNF - Protein NDNF precursor - Homo sapiens (Human) - NDNF gene Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645). Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:20969804, PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (PubMed:31883645). Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764). Indicus|evm.model.CM009496.1.19 Q9NQX1 PRDM5_HUMAN 91.319 0.996485 0.903175 PRDM5 - PR domain zinc finger protein 5 - Homo sapiens (Human) - PRDM5 gene Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells. Indicus|evm.model.CM009496.1.20 Q6REY9 RHG20_RAT 63.636 0.340807 0.188663 Arhgap20 - Rho GTPase-activating protein 20 - Rattus norvegicus (Rat) - Arhgap20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009496.1.22 Q9P2F6 RHG20_HUMAN 61.111 0.198502 0.224181 ARHGAP20 - Rho GTPase-activating protein 20 - Homo sapiens (Human) - ARHGAP20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009496.1.23 Q9P2F6 RHG20_HUMAN 66.667 0.0553236 0.804366 ARHGAP20 - Rho GTPase-activating protein 20 - Homo sapiens (Human) - ARHGAP20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009496.1.25 Q13257 MD2L1_HUMAN 93.243 0.257143 1.36585 MAD2L1 - Mitotic spindle assembly checkpoint protein MAD2A - Homo sapiens (Human) - MAD2L1 gene Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:29162720, PubMed:15024386). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (PubMed:29162720). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (PubMed:10700282, PubMed:11804586, PubMed:15024386). Indicus|evm.model.CM009496.1.27 Q6REY9 RHG20_RAT 55.000 0.393103 0.122673 Arhgap20 - Rho GTPase-activating protein 20 - Rattus norvegicus (Rat) - Arhgap20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009496.1.28 Q9P2F6 RHG20_HUMAN 66.154 0.394572 0.402183 ARHGAP20 - Rho GTPase-activating protein 20 - Homo sapiens (Human) - ARHGAP20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009496.1.29 Q13257 MD2L1_HUMAN 97.073 0.990291 1.00488 MAD2L1 - Mitotic spindle assembly checkpoint protein MAD2A - Homo sapiens (Human) - MAD2L1 gene Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:29162720, PubMed:15024386). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (PubMed:29162720). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (PubMed:10700282, PubMed:11804586, PubMed:15024386). Indicus|evm.model.CM009496.1.30 Q9P2F6 RHG20_HUMAN 73.267 0.160976 0.516373 ARHGAP20 - Rho GTPase-activating protein 20 - Homo sapiens (Human) - ARHGAP20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009496.1.32 P31621 ENV_JSRV 54.430 0.987342 0.128455 env - Envelope glycoprotein precursor - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - env gene The envelope proteins induce cell transformation leading to ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer of sheep and goat. They bind to the HYAL2 receptor for cell entry. Env proteins probably do not act as oncogenes by themselves, but may rather liberate an oncogenic factor that would normally be negatively regulated. One mechanism of transformation seems to involve activation of the phosphoinositide-3-OH kinase (PI3K)/Akt pathway but does not involve the virus receptor HYAL2, and the other seems to involve Env binding to HYAL2, HYAL2 degradation, and activation of the MST1R receptor tyrosine kinase, which is normally suppressed by HYAL2. Indicus|evm.model.CM009496.1.34 Q6REY9 RHG20_RAT 59.524 0.528908 0.395093 Arhgap20 - Rho GTPase-activating protein 20 - Rattus norvegicus (Rat) - Arhgap20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009496.1.35 Q28156 PDE5A_BOVIN 100.000 0.997691 1.00116 PDE5A - cGMP-specific 3',5'-cyclic phosphodiesterase - Bos taurus (Bovine) - PDE5A gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity). Indicus|evm.model.CM009496.1.36 Q56JX9 FABPI_BOVIN 96.212 0.984848 1 FABP2 - Fatty acid-binding protein, intestinal - Bos taurus (Bovine) - FABP2 gene FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity). Indicus|evm.model.CM009496.1.37 Q8WVX3 CD003_HUMAN 72.059 0.697917 1.45455 C4orf3 - Uncharacterized protein C4orf3 - Homo sapiens (Human) - C4orf3 gene Indicus|evm.model.CM009496.1.38 Q70EK8 UBP53_HUMAN 82.778 0.969452 1.03728 USP53 - Inactive ubiquitin carboxyl-terminal hydrolase 53 - Homo sapiens (Human) - USP53 gene Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245). Indicus|evm.model.CM009496.1.39 Q5E9V3 MYOZ2_BOVIN 99.512 0.990291 0.780303 MYOZ2 - Myozenin-2 - Bos taurus (Bovine) - MYOZ2 gene Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). Indicus|evm.model.CM009496.1.40 Q9UMS6 SYNP2_HUMAN 86.563 0.998167 0.99817 SYNPO2 - Synaptopodin-2 - Homo sapiens (Human) - SYNPO2 gene Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). Indicus|evm.model.CM009496.1.41 O94855 SC24D_HUMAN 91.851 0.895401 1.07461 SEC24D - Protein transport protein Sec24D - Homo sapiens (Human) - SEC24D gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). Indicus|evm.model.CM009496.1.42 A4IFD8 MET14_BOVIN 100.000 0.995624 1.00219 METTL14 - N6-adenosine-methyltransferase non-catalytic subunit - Bos taurus (Bovine) - METTL14 gene The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (By similarity). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). Indicus|evm.model.CM009496.1.43 Q5G268 NETR_NOMLE 89.621 0.841667 0.822857 PRSS12 - Neurotrypsin precursor - Nomascus leucogenys (Northern white-cheeked gibbon) - PRSS12 gene Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. Indicus|evm.model.CM009496.1.44 Q5E947 PRDX1_BOVIN 79.259 0.930556 0.723618 PRDX1 - Peroxiredoxin-1 - Bos taurus (Bovine) - PRDX1 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). Indicus|evm.model.CM009496.1.45 O95803 NDST3_HUMAN 96.000 0.597802 0.521191 NDST3 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 - Homo sapiens (Human) - NDST3 gene Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. Indicus|evm.model.CM009496.1.46 Q99880 H2B1L_HUMAN 83.621 0.982906 0.928571 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009496.1.47 Q9WTX6 CUL1_MOUSE 72.678 0.298025 0.717784 Cul1 - Cullin-1 - Mus musculus (Mouse) - Cul1 gene Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Indicus|evm.model.CM009496.1.48 Q8N609 TR1L1_HUMAN 71.053 0.856818 1.19241 TRAM1L1 - Translocating chain-associated membrane protein 1-like 1 - Homo sapiens (Human) - TRAM1L1 gene Stimulatory or required for the translocation of secretory proteins across the ER membrane. Indicus|evm.model.CM009496.1.49 O77834 PRDX6_BOVIN 85.870 0.892157 0.455357 PRDX6 - Peroxiredoxin-6 - Bos taurus (Bovine) - PRDX6 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10409692, PubMed:2373154). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10409692). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10409692, PubMed:2373154, PubMed:9787801). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity). Indicus|evm.model.CM009496.1.50 Q99877 H2B1N_HUMAN 93.023 0.85 0.793651 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009496.1.52 Q3ZBE1 ARMC1_BOVIN 70.297 0.868421 0.673759 ARMC1 - Armadillo repeat-containing protein 1 - Bos taurus (Bovine) - ARMC1 gene In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. Indicus|evm.model.CM009496.1.53 Q9H3R1 NDST4_HUMAN 96.942 0.883469 0.423165 NDST4 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 - Homo sapiens (Human) - NDST4 gene Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). Indicus|evm.model.CM009496.1.54 Q9H3R1 NDST4_HUMAN 92.857 0.996176 0.599771 NDST4 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 - Homo sapiens (Human) - NDST4 gene Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). Indicus|evm.model.CM009496.1.55 Q16880 CGT_HUMAN 95.009 0.99631 1.00185 UGT8 - 2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor - Homo sapiens (Human) - UGT8 gene Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed:9125199). Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity). Indicus|evm.model.CM009496.1.56 Q5R7J9 IF4G2_PONAB 86.667 0.885417 0.423374 EIF4G2 - Eukaryotic translation initiation factor 4 gamma 2 - Pongo abelii (Sumatran orangutan) - EIF4G2 gene Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity). Indicus|evm.model.CM009496.1.57 P84100 RL19_RAT 62.774 0.680982 0.831633 Rpl19 - 60S ribosomal protein L19 - Rattus norvegicus (Rat) - Rpl19 gene cytosolic large ribosomal subunit, polysomal ribosome, synapse, 5.8S rRNA binding, large ribosomal subunit rRNA binding, RNA binding, structural constituent of ribosome, cytoplasmic translation, liver regeneration Indicus|evm.model.CM009496.1.58 Q5FYB0 ARSJ_HUMAN 93.991 0.968685 0.799666 ARSJ - Arylsulfatase J precursor - Homo sapiens (Human) - ARSJ gene actin cytoskeleton, endoplasmic reticulum lumen, arylsulfatase activity Indicus|evm.model.CM009496.1.59 Q95266 KCC2D_PIG 100.000 0.993737 0.95992 CAMK2D - Calcium/calmodulin-dependent protein kinase type II subunit delta - Sus scrofa (Pig) - CAMK2D gene Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor (By similarity). Indicus|evm.model.CM009496.1.60 Q12955 ANK3_HUMAN 77.778 0.00933582 0.856523 ANK3 - Ankyrin-3 - Homo sapiens (Human) - ANK3 gene In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Indicus|evm.model.CM009496.1.62 Q4G0J3 LARP7_HUMAN 85.739 0.996546 0.994845 LARP7 - La-related protein 7 - Homo sapiens (Human) - LARP7 gene RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18483487, PubMed:18281698). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). Indicus|evm.model.CM009496.1.63 Q86YA3 ZGRF1_HUMAN 71.904 0.954054 1.05513 ZGRF1 - Protein ZGRF1 - Homo sapiens (Human) - ZGRF1 gene cytoplasm, 5'-flap endonuclease activity, RNA binding, replication fork reversal Indicus|evm.model.CM009496.1.65 Q9H2A3 NGN2_HUMAN 91.544 0.99262 0.996324 NEUROG2 - Neurogenin-2 - Homo sapiens (Human) - NEUROG2 gene Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Indicus|evm.model.CM009496.1.66 Q96QP1 ALPK1_HUMAN 77.311 0.0985556 0.946141 ALPK1 - Alpha-protein kinase 1 - Homo sapiens (Human) - ALPK1 gene Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161). Indicus|evm.model.CM009496.1.67 A2VDM0 TIFA_BOVIN 98.919 0.989247 1.00541 TIFA - TRAF-interacting protein with FHA domain-containing protein A - Bos taurus (Bovine) - TIFA gene Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of proinflammatory NF-kappa-B signaling. Indicus|evm.model.CM009496.1.68 Q63HQ0 AP1AR_HUMAN 94.040 0.993399 1.00331 AP1AR - AP-1 complex-associated regulatory protein - Homo sapiens (Human) - AP1AR gene Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. Indicus|evm.model.CM009496.1.69 Q17QE0 F241A_BOVIN 100.000 0.985612 1.00725 FAM241A - Uncharacterized protein FAM241A - Bos taurus (Bovine) - FAM241A gene intracellular membrane-bounded organelle Indicus|evm.model.CM009496.1.72 P97474 PITX2_MOUSE 74.603 0.690141 0.223975 Pitx2 - Pituitary homeobox 2 - Mus musculus (Mouse) - Pitx2 gene Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform Ptx2c is involved in left-right asymmetry the developing embryo. Indicus|evm.model.CM009496.1.73 Q9R0W1 PITX2_RAT 96.308 0.993865 1.00617 Pitx2 - Pituitary homeobox 2 - Rattus norvegicus (Rat) - Pitx2 gene Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach (By similarity). Indicus|evm.model.CM009496.1.74 Q32LQ0 AMPE_BOVIN 99.895 0.99791 1.00105 ENPEP - Glutamyl aminopeptidase - Bos taurus (Bovine) - ENPEP gene Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. Indicus|evm.model.CM009496.1.75 Q4R7Y2 RL10_MACFA 71.739 0.775862 0.271028 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009496.1.76 P62309 RUXG_MOUSE 98.684 0.974026 1.01316 Snrpg - Small nuclear ribonucleoprotein G - Mus musculus (Mouse) - Snrpg gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. Indicus|evm.model.CM009496.1.77 Q9H5J4 ELOV6_HUMAN 94.318 0.992453 1 ELOVL6 - Elongation of very long chain fatty acids protein 6 - Homo sapiens (Human) - ELOVL6 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Indicus|evm.model.CM009496.1.78 Q00968 EGF_PIG 55.556 0.30721 0.262768 EGF - Pro-epidermal growth factor precursor - Sus scrofa (Pig) - EGF gene EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). Indicus|evm.model.CM009496.1.79 Q3SXY7 LRIT3_HUMAN 75.240 0.992038 0.92489 LRIT3 - Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 precursor - Homo sapiens (Human) - LRIT3 gene Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (By similarity). Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina (PubMed:28334377). Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (By similarity). Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (By similarity). May also have a role in cone synapse formation (By similarity). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (PubMed:22673519). Could be a regulator of the FGFRs (PubMed:22673519). Indicus|evm.model.CM009496.1.80 Q9NY12 GAR1_HUMAN 95.455 0.134884 2.97235 GAR1 - H/ACA ribonucleoprotein complex subunit 1 - Homo sapiens (Human) - GAR1 gene Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Indicus|evm.model.CM009496.1.81 Q9WUW3 CFAI_RAT 69.036 0.917609 1.02483 Cfi - Complement factor I precursor - Rattus norvegicus (Rat) - Cfi gene Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. Indicus|evm.model.CM009496.1.82 Q9BZM1 PG12A_HUMAN 94.828 0.930108 0.984127 PLA2G12A - Group XIIA secretory phospholipase A2 precursor - Homo sapiens (Human) - PLA2G12A gene PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine. Indicus|evm.model.CM009496.1.83 Q3T0P5 CASP6_BOVIN 100.000 0.993197 1.00341 CASP6 - Caspase-6 precursor - Bos taurus (Bovine) - CASP6 gene Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity. During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation. Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (By similarity). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis. Regulates B-cell programs both during early development and after antigen stimulation (By similarity). In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses. Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (By similarity). Indicus|evm.model.CM009496.1.84 Q9NWR8 MCUB_HUMAN 80.896 0.988095 1 MCUB - Calcium uniporter regulatory subunit MCUb, mitochondrial precursor - Homo sapiens (Human) - MCUB gene Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Indicus|evm.model.CM009496.1.85 O95487 SC24B_HUMAN 91.575 0.998406 0.989748 SEC24B - Protein transport protein Sec24B - Homo sapiens (Human) - SEC24B gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). Indicus|evm.model.CM009496.1.86 Q9BXS0 COPA1_HUMAN 80.808 0.989899 0.151376 COL25A1 - Collagen alpha-1(XXV) chain - Homo sapiens (Human) - COL25A1 gene Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. Indicus|evm.model.CM009496.1.87 Q9BXS0 COPA1_HUMAN 88.768 0.965385 0.397554 COL25A1 - Collagen alpha-1(XXV) chain - Homo sapiens (Human) - COL25A1 gene Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. Indicus|evm.model.CM009496.1.89 Q5E9S4 AT2L1_BOVIN 100.000 0.995984 1.00201 ETNPPL - Ethanolamine-phosphate phospho-lyase - Bos taurus (Bovine) - ETNPPL gene Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde. Indicus|evm.model.CM009496.1.90 Q2KID7 OSTC_BOVIN 100.000 0.986667 1.00671 OSTC - Oligosaccharyltransferase complex subunit OSTC - Bos taurus (Bovine) - OSTC gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. Indicus|evm.model.CM009496.1.91 Q29223 RL34_PIG 100.000 0.983051 1.00855 RPL34 - 60S ribosomal protein L34 - Sus scrofa (Pig) - RPL34 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009496.1.93 Q9UJU2 LEF1_HUMAN 98.972 0.93494 1.0401 LEF1 - Lymphoid enhancer-binding factor 1 - Homo sapiens (Human) - LEF1 gene Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity). Indicus|evm.model.CM009496.1.94 Q0IIF9 CP2U1_BOVIN 99.767 0.56168 1.40331 CYP2U1 - Cytochrome P450 2U1 - Bos taurus (Bovine) - CYP2U1 gene A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May downregulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin. Indicus|evm.model.CM009496.1.95 Q4R763 SMS2_MACFA 95.890 0.994536 1.00274 SGMS2 - Phosphatidylcholine:ceramide cholinephosphotransferase 2 - Macaca fascicularis (Crab-eating macaque) - SGMS2 gene Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane. Does not use free phosphorylcholine or CDP-choline as donors. Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1. Required for normal bone matrix mineralization. Indicus|evm.model.CM009496.1.96 O43252 PAPS1_HUMAN 98.397 0.9968 1.0016 PAPSS1 - Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 - Homo sapiens (Human) - PAPSS1 gene Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). Indicus|evm.model.CM009496.1.97 Q9UBU2 DKK2_HUMAN 84.706 0.51634 0.590734 DKK2 - Dickkopf-related protein 2 precursor - Homo sapiens (Human) - DKK2 gene Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). Indicus|evm.model.CM009496.1.98 Q9UBU2 DKK2_HUMAN 96.757 0.968421 0.733591 DKK2 - Dickkopf-related protein 2 precursor - Homo sapiens (Human) - DKK2 gene Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). Indicus|evm.model.CM009496.1.99 P0DJR0 GIMD1_HUMAN 85.496 0.783133 0.764977 GIMD1 - GTPase IMAP family member GIMD1 - Homo sapiens (Human) - GIMD1 gene Indicus|evm.model.CM009496.1.100 Q12904 AIMP1_HUMAN 86.581 0.993631 1.00641 AIMP1 - Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 - Homo sapiens (Human) - AIMP1 gene Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550). Indicus|evm.model.CM009496.1.101 Q8TEA7 TBCK_HUMAN 96.305 0.97062 1.02912 TBCK - TBC domain-containing protein kinase-like protein - Homo sapiens (Human) - TBCK gene Involved in the modulation of mTOR signaling and expression of mTOR complex components (PubMed:27040691, PubMed:23977024). Involved in the regulation of cell proliferation and growth (PubMed:23977024, PubMed:24576458). Involved in the control of actin-cytoskeleton organization (PubMed:23977024). Indicus|evm.model.CM009496.1.102 Q63610 TPM3_RAT 88.583 0.992157 1.02823 Tpm3 - Tropomyosin alpha-3 chain - Rattus norvegicus (Rat) - Tpm3 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Indicus|evm.model.CM009496.1.103 Q5RBP1 NPNT_PONAB 83.725 0.988333 1.06195 NPNT - Nephronectin precursor - Pongo abelii (Sumatran orangutan) - NPNT gene Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity). Indicus|evm.model.CM009496.1.104 A5PKL6 GSTCD_BOVIN 99.513 0.877944 0.740095 GSTCD - Glutathione S-transferase C-terminal domain-containing protein - Bos taurus (Bovine) - GSTCD gene cytoplasm Indicus|evm.model.CM009496.1.105 Q32LL5 INT12_BOVIN 99.351 0.99568 1.00216 INTS12 - Integrator complex subunit 12 - Bos taurus (Bovine) - INTS12 gene Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Indicus|evm.model.CM009496.1.106 Q9NXL2 ARH38_HUMAN 87.661 0.997433 1.00257 ARHGEF38 - Rho guanine nucleotide exchange factor 38 - Homo sapiens (Human) - ARHGEF38 gene May act as a guanine-nucleotide releasing factor. Indicus|evm.model.CM009496.1.107 Q9H2U2 IPYR2_HUMAN 82.456 0.994169 1.02695 PPA2 - Inorganic pyrophosphatase 2, mitochondrial precursor - Homo sapiens (Human) - PPA2 gene Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598). Indicus|evm.model.CM009496.1.108 Q6N021 TET2_HUMAN 81.383 0.999004 1.003 TET2 - Methylcytosine dioxygenase TET2 - Homo sapiens (Human) - TET2 gene Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Indicus|evm.model.CM009496.1.109 Q9EQC9 CXXC4_RAT 89.796 0.833333 0.878788 Cxxc4 - CXXC-type zinc finger protein 4 - Rattus norvegicus (Rat) - Cxxc4 gene Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity). Indicus|evm.model.CM009496.1.111 O97512 NK3R_RABIT 90.476 0.791209 0.389722 TACR3 - Neuromedin-K receptor - Oryctolagus cuniculus (Rabbit) - TACR3 gene This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Indicus|evm.model.CM009496.1.112 P62262 1433E_SHEEP 90.090 0.982143 0.439216 YWHAE - 14-3-3 protein epsilon - Ovis aries (Sheep) - YWHAE gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Indicus|evm.model.CM009496.1.113 O97512 NK3R_RABIT 94.340 0.78607 0.430407 TACR3 - Neuromedin-K receptor - Oryctolagus cuniculus (Rabbit) - TACR3 gene This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Indicus|evm.model.CM009496.1.114 Q02224 CENPE_HUMAN 70.295 0.98136 1.01296 CENPE - Centromere-associated protein E precursor - Homo sapiens (Human) - CENPE gene Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:7889940, PubMed:23891108, PubMed:25395579). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). Indicus|evm.model.CM009496.1.115 Q3T046 BDH2_BOVIN 99.592 0.99187 1.00408 BDH2 - 3-hydroxybutyrate dehydrogenase type 2 - Bos taurus (Bovine) - BDH2 gene Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). Indicus|evm.model.CM009496.1.116 Q86UD5 SL9B2_HUMAN 83.240 0.996269 0.998138 SLC9B2 - Sodium/hydrogen exchanger 9B2 - Homo sapiens (Human) - SLC9B2 gene Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity). Indicus|evm.model.CM009496.1.117 Q4ZJI4 SL9B1_HUMAN 68.023 0.996109 0.998058 SLC9B1 - Sodium/hydrogen exchanger 9B1 - Homo sapiens (Human) - SLC9B1 gene Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility. Indicus|evm.model.CM009496.1.118 Q8N5K1 CISD2_HUMAN 100.000 0.985294 1.00741 CISD2 - CDGSH iron-sulfur domain-containing protein 2 - Homo sapiens (Human) - CISD2 gene Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. Indicus|evm.model.CM009496.1.119 P61078 UB2D3_RAT 100.000 0.981982 0.755102 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009496.1.120 Q29444 MANBA_BOVIN 88.125 0.517431 0.620023 MANBA - Beta-mannosidase precursor - Bos taurus (Bovine) - MANBA gene Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. Indicus|evm.model.CM009496.1.121 Q6F3J0 NFKB1_CANLF 92.387 0.997938 0.997942 NFKB1 - Nuclear factor NF-kappa-B p105 subunit - Canis lupus familiaris (Dog) - NFKB1 gene NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105 (By similarity). Indicus|evm.model.CM009496.1.122 P10854 H2B1M_MOUSE 97.297 0.935897 0.619048 H2bc14 - Histone H2B type 1-M - Mus musculus (Mouse) - H2bc14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009496.1.123 Q9C0K1 S39A8_HUMAN 92.191 0.995671 1.00435 SLC39A8 - Metal cation symporter ZIP8 precursor - Homo sapiens (Human) - SLC39A8 gene Electroneutral transporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis or immunity (PubMed:12504855, PubMed:22898811, PubMed:23403290, PubMed:29337306, PubMed:26637978, PubMed:29453449). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation, a bicarbonate and a selenite anion or yet a metal cation and two bicarbonate anions (PubMed:27166256, PubMed:31699897). May also transport iron, mercury and cobalt through membranes (PubMed:22898811). Beside these endogenous cellular substrates, also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:27466201). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:29337306). Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450). Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290, PubMed:28056086). Protects, for instance, cells from injury and death at the onset of inflammation (PubMed:18390834). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). At the apical membrane of hepatocytes, reclaims manganese from the bile and regulates, through the systemic levels of the nutrient, the activity of manganese-dependent enzymes (PubMed:28481222). Also participates in manganese reabsorption in the proximal tubule of the kidney (PubMed:26637978). By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain (PubMed:26637978, PubMed:31699897). Through manganese cellular uptake also participates in mitochondrial proper function (PubMed:29453449). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (PubMed:19401385). Indicus|evm.model.CM009496.1.124 Q8NDB2 BANK1_HUMAN 74.395 0.997439 0.994904 BANK1 - B-cell scaffold protein with ankyrin repeats - Homo sapiens (Human) - BANK1 gene Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. Indicus|evm.model.CM009496.1.125 P48452 PP2BA_BOVIN 100.000 0.996169 1.00192 PPP3CA - Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform - Bos taurus (Bovine) - PPP3CA gene Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15967565, PubMed:1715244, PubMed:1328240, PubMed:16411749). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (By similarity). Dephosphorylates heat shock protein HSPB1 (PubMed:1328240). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (By similarity). Indicus|evm.model.CM009496.1.126 Q9ULC0 MUCEN_HUMAN 56.489 0.992366 1.00383 EMCN - Endomucin precursor - Homo sapiens (Human) - EMCN gene Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. Indicus|evm.model.CM009496.1.127 A2VDT9 DDT4L_BOVIN 100.000 0.989691 1.00518 DDIT4L - DNA damage-inducible transcript 4-like protein - Bos taurus (Bovine) - DDIT4L gene Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Indicus|evm.model.CM009496.1.128 Q6YNC8 H2AZ_SHEEP 99.020 0.943925 0.835938 H2AZ1 - Histone H2A.Z - Ovis aries (Sheep) - H2AZ1 gene Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). Indicus|evm.model.CM009496.1.129 Q0IIE8 DJB14_BOVIN 99.736 0.994737 1.00264 DNAJB14 - DnaJ homolog subfamily B member 14 - Bos taurus (Bovine) - DNAJB14 gene Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear. Indicus|evm.model.CM009496.1.130 Q17QQ1 LTOR3_BOVIN 100.000 0.984 1.00806 LAMTOR3 - Ragulator complex protein LAMTOR3 - Bos taurus (Bovine) - LAMTOR3 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity). Indicus|evm.model.CM009496.1.131 Q9UN19 DAPP1_HUMAN 95.785 0.925267 1.00357 DAPP1 - Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide - Homo sapiens (Human) - DAPP1 gene May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. Indicus|evm.model.CM009496.1.132 D6RIA3 CD054_HUMAN 85.643 0.980822 1.01785 C4orf54 - Uncharacterized protein C4orf54 - Homo sapiens (Human) - C4orf54 gene Indicus|evm.model.CM009496.1.133 P55156 MTP_BOVIN 99.887 0.989944 1.00902 MTTP - Microsomal triglyceride transfer protein large subunit precursor - Bos taurus (Bovine) - MTTP gene Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:8876250). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity). Indicus|evm.model.CM009496.1.134 Q3MHI8 TM10A_BOVIN 100.000 0.9941 1.00296 TRMT10A - tRNA methyltransferase 10 homolog A - Bos taurus (Bovine) - TRMT10A gene S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs. Indicus|evm.model.CM009496.1.135 Q53FE4 CD017_HUMAN 73.889 0.994286 0.97493 C4orf17 - Uncharacterized protein C4orf17 - Homo sapiens (Human) - C4orf17 gene Indicus|evm.model.CM009496.1.136 P40394 ADH7_HUMAN 81.771 0.62215 0.795337 ADH7 - All-trans-retinol dehydrogenase [NAD(+)] ADH7 - Homo sapiens (Human) - ADH7 gene Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed:15369820, PubMed:16787387, PubMed:9600267). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387, PubMed:15369820). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed:9600267, PubMed:15369820, PubMed:16787387). Indicus|evm.model.CM009496.1.137 P00328 ADH1S_HORSE 77.062 0.994859 1.04011 Alcohol dehydrogenase S chain - Equus caballus (Horse) Indicus|evm.model.CM009496.1.138 Q9NY97 B3GN2_HUMAN 88.265 0.890411 0.551637 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Homo sapiens (Human) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. Indicus|evm.model.CM009496.1.139 P80338 ADH1_STRCA 58.806 0.994048 0.898396 ADH1 - Alcohol dehydrogenase 1 - Struthio camelus (Common ostrich) - ADH1 gene Indicus|evm.model.CM009496.1.140 Q5R7Z8 ADH6_PONAB 79.255 0.994681 1.00267 ADH6 - Alcohol dehydrogenase 6 - Pongo abelii (Sumatran orangutan) - ADH6 gene Indicus|evm.model.CM009496.1.141 P08319 ADH4_HUMAN 77.005 0.750503 1.30789 ADH4 - All-trans-retinol dehydrogenase [NAD(+)] ADH4 - Homo sapiens (Human) - ADH4 gene Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444). Indicus|evm.model.CM009496.1.142 Q3ZC42 ADHX_BOVIN 100.000 0.994667 1.00267 ADH5 - Alcohol dehydrogenase class-3 - Bos taurus (Bovine) - ADH5 gene Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Indicus|evm.model.CM009496.1.143 A6QLA4 MAP1_BOVIN 99.741 0.994832 1.00259 METAP1 - Methionine aminopeptidase 1 - Bos taurus (Bovine) - METAP1 gene Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Indicus|evm.model.CM009496.1.144 Q9N0T5 IF4E_BOVIN 99.539 0.935065 1.06452 EIF4E - Eukaryotic translation initiation factor 4E - Bos taurus (Bovine) - EIF4E gene Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (By similarity). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (By similarity). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Indicus|evm.model.CM009496.1.145 Q1JP79 ARC1A_BOVIN 79.019 0.99403 0.905405 ARPC1A - Actin-related protein 2/3 complex subunit 1A - Bos taurus (Bovine) - ARPC1A gene Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). Indicus|evm.model.CM009496.1.146 A6H767 NP1L1_BOVIN 98.561 0.985714 0.358056 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009496.1.147 Q5R4D4 NP1L1_PONAB 97.340 0.968912 0.493606 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Pongo abelii (Sumatran orangutan) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009496.1.148 Q17QJ5 TSN5_BOVIN 100.000 0.815873 1.17537 TSPAN5 - Tetraspanin-5 - Bos taurus (Bovine) - TSPAN5 gene Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44. Indicus|evm.model.CM009496.1.149 P52306 GDS1_HUMAN 95.881 0.993443 1.00494 RAP1GDS1 - Rap1 GTPase-GDP dissociation stimulator 1 - Homo sapiens (Human) - RAP1GDS1 gene Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein (PubMed:1549351, PubMed:11948427). Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed:24349085). Indicus|evm.model.CM009496.1.150 Q8N412 STPG2_HUMAN 58.755 0.726496 0.764706 STPG2 - Sperm-tail PG-rich repeat-containing protein 2 - Homo sapiens (Human) - STPG2 gene Indicus|evm.model.CM009496.1.153 O00273 DFFA_HUMAN 71.269 0.992509 0.806647 DFFA - DNA fragmentation factor subunit alpha - Homo sapiens (Human) - DFFA gene Inhibitor of the caspase-activated DNase (DFF40). Indicus|evm.model.CM009496.1.154 Q2KI85 SMTL2_BOVIN 47.692 0.5 0.266376 SMTNL2 - Smoothelin-like protein 2 - Bos taurus (Bovine) - SMTNL2 gene filamentous actin, I band, M band, microtubule organizing center, protein phosphatase 1 binding, tropomyosin binding, actin cytoskeleton organization, positive regulation of vasoconstriction Indicus|evm.model.CM009496.1.155 Q8NI29 FBX27_HUMAN 46.988 0.955466 0.872792 FBXO27 - F-box only protein 27 - Homo sapiens (Human) - FBXO27 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Indicus|evm.model.CM009496.1.156 A7MB35 ODPA_BOVIN 88.235 0.994898 1.00513 PDHA1 - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor - Bos taurus (Bovine) - PDHA1 gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Indicus|evm.model.CM009496.1.157 O95185 UNC5C_HUMAN 99.495 0.860262 0.245972 UNC5C - Netrin receptor UNC5C precursor - Homo sapiens (Human) - UNC5C gene Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Indicus|evm.model.CM009496.1.158 P36898 BMR1B_MOUSE 98.805 0.996024 1.00199 Bmpr1b - Bone morphogenetic protein receptor type-1B precursor - Mus musculus (Mouse) - Bmpr1b gene On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1. Receptor for GDF5 (PubMed:26105076, PubMed:19229295). Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Indicus|evm.model.CM009496.1.159 Q96HC4 PDLI5_HUMAN 89.430 0.996644 1 PDLIM5 - PDZ and LIM domain protein 5 - Homo sapiens (Human) - PDLIM5 gene May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). Indicus|evm.model.CM009496.1.160 O60760 HPGDS_HUMAN 86.432 0.99 1.00503 HPGDS - Hematopoietic prostaglandin D synthase - Homo sapiens (Human) - HPGDS gene Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Indicus|evm.model.CM009496.1.161 E1B7X9 SMRCD_BOVIN 97.668 0.998056 1.00097 SMARCAD1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 - Bos taurus (Bovine) - SMARCAD1 gene DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity). Indicus|evm.model.CM009496.1.162 Q92858 ATOH1_HUMAN 92.090 0.994334 0.997175 ATOH1 - Protein atonal homolog 1 - Homo sapiens (Human) - ATOH1 gene Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). Indicus|evm.model.CM009496.1.163 O43424 GRID2_HUMAN 99.545 0.88664 0.245283 GRID2 - Glutamate receptor ionotropic, delta-2 precursor - Homo sapiens (Human) - GRID2 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511). Indicus|evm.model.CM009496.1.164 Q61625 GRID2_MOUSE 99.369 0.946108 0.331678 Grid2 - Glutamate receptor ionotropic, delta-2 precursor - Mus musculus (Mouse) - Grid2 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex. Indicus|evm.model.CM009496.1.165 O43424 GRID2_HUMAN 98.837 0.784404 0.216485 GRID2 - Glutamate receptor ionotropic, delta-2 precursor - Homo sapiens (Human) - GRID2 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511). Indicus|evm.model.CM009496.1.166 O43424 GRID2_HUMAN 99.375 0.883333 0.178749 GRID2 - Glutamate receptor ionotropic, delta-2 precursor - Homo sapiens (Human) - GRID2 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511). Indicus|evm.model.CM009496.1.167 Q58DT1 RL7_BOVIN 96.078 0.980583 0.415323 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Indicus|evm.model.CM009496.1.168 Q58DT1 RL7_BOVIN 96.226 0.981132 0.21371 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Indicus|evm.model.CM009496.1.169 Q61625 GRID2_MOUSE 83.582 0.767442 0.0854022 Grid2 - Glutamate receptor ionotropic, delta-2 precursor - Mus musculus (Mouse) - Grid2 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex. Indicus|evm.model.CM009496.1.170 P15907 SIAT1_HUMAN 78.621 0.971831 0.349754 ST6GAL1 - Beta-galactoside alpha-2,6-sialyltransferase 1 - Homo sapiens (Human) - ST6GAL1 gene Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. Indicus|evm.model.CM009496.1.171 Q5R7F7 SYFB_PONAB 90.747 0.985507 0.468591 FARSB - Phenylalanine--tRNA ligase beta subunit - Pongo abelii (Sumatran orangutan) - FARSB gene phenylalanine-tRNA ligase complex, phenylalanine-tRNA ligase activity, phenylalanyl-tRNA aminoacylation, protein heterotetramerization Indicus|evm.model.CM009496.1.172 Q9NSD9 SYFB_HUMAN 93.363 0.907258 0.421053 FARSB - Phenylalanine--tRNA ligase beta subunit - Homo sapiens (Human) - FARSB gene cytoplasm, cytosol, membrane, phenylalanine-tRNA ligase complex, phenylalanine-tRNA ligase activity, phenylalanyl-tRNA aminoacylation, protein heterotetramerization, translation, tRNA aminoacylation for protein translation Indicus|evm.model.CM009496.1.173 Q1RMS0 CCSE1_BOVIN 99.723 0.998617 0.973082 CCSER1 - Serine-rich coiled-coil domain-containing protein 1 - Bos taurus (Bovine) - CCSER1 gene Indicus|evm.model.CM009496.1.174 Q13201 MMRN1_HUMAN 70.627 0.998225 0.917752 MMRN1 - Multimerin-1 precursor - Homo sapiens (Human) - MMRN1 gene Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. Indicus|evm.model.CM009496.1.176 Q3T0G8 SYUA_BOVIN 100.000 0.985816 1.00714 SNCA - Alpha-synuclein - Bos taurus (Bovine) - SNCA gene Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity. Indicus|evm.model.CM009496.1.177 Q6ZVF9 GRIN3_HUMAN 70.460 0.997439 1.00644 GPRIN3 - G protein-regulated inducer of neurite outgrowth 3 - Homo sapiens (Human) - GPRIN3 gene May be involved in neurite outgrowth. Indicus|evm.model.CM009496.1.179 Q4W5G0 TIGD2_HUMAN 100.000 0.394256 0.729524 TIGD2 - Tigger transposable element-derived protein 2 - Homo sapiens (Human) - TIGD2 gene nucleus, DNA binding Indicus|evm.model.CM009496.1.180 Q8HYW0 FA13A_BOVIN 99.420 0.688312 1.43615 FAM13A - Protein FAM13A - Bos taurus (Bovine) - FAM13A gene Indicus|evm.model.CM009496.1.181 Q15034 HERC3_HUMAN 97.905 0.998097 1.00095 HERC3 - Probable E3 ubiquitin-protein ligase HERC3 - Homo sapiens (Human) - HERC3 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Indicus|evm.model.CM009496.1.182 Q2T9V7 PREY_BOVIN 99.123 0.982609 1.00877 PREY - Protein preY, mitochondrial precursor - Bos taurus (Bovine) - PREY gene glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, GPI anchor biosynthetic process Indicus|evm.model.CM009496.1.183 Q9UII4 HERC5_HUMAN 76.190 0.968239 1.01465 HERC5 - E3 ISG15--protein ligase HERC5 - Homo sapiens (Human) - HERC5 gene Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. Indicus|evm.model.CM009496.1.184 Q8IVU3 HERC6_HUMAN 73.653 0.997053 0.996086 HERC6 - Probable E3 ubiquitin-protein ligase HERC6 - Homo sapiens (Human) - HERC6 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Indicus|evm.model.CM009496.1.186 Q2PC20 PPM1K_BOVIN 100.000 0.994638 1.00269 PPM1K - Protein phosphatase 1K, mitochondrial precursor - Bos taurus (Bovine) - PPM1K gene Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. Indicus|evm.model.CM009496.1.187 Q4R8Y8 RU2A_MACFA 98.039 0.992157 1 SNRPA1 - U2 small nuclear ribonucleoprotein A' - Macaca fascicularis (Crab-eating macaque) - SNRPA1 gene Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. Indicus|evm.model.CM009496.1.188 Q4GZT4 ABCG2_BOVIN 99.695 0.992413 1.00611 ABCG2 - Broad substrate specificity ATP-binding cassette transporter ABCG2 - Bos taurus (Bovine) - ABCG2 gene Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity). Mediates the secretion of the riboflavin and biotin vitamins into milk. Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain. It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (By similarity). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus. May play a role in early stem cell self-renewal by blocking differentiation (By similarity). Indicus|evm.model.CM009496.1.189 Q4GZT3 PKD2_BOVIN 100.000 0.99794 1.00103 PKD2 - Polycystin-2 - Bos taurus (Bovine) - PKD2 gene Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (By similarity). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By similarity). Together with TRPV4, forms mechano- and thermosensitive channels in cilium. PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity). Indicus|evm.model.CM009496.1.190 P31096 OSTP_BOVIN 100.000 0.817109 1.21942 SPP1 - Osteopontin precursor - Bos taurus (Bovine) - SPP1 gene Major non-collagenous bone protein that binds tightly to hydroxyapatite (Probable). Appears to form an integral part of the mineralized matrix (Probable). Probably important to cell-matrix interaction (Probable). Indicus|evm.model.CM009496.1.191 Q9NQ76 MEPE_HUMAN 61.466 0.94955 1.05714 MEPE - Matrix extracellular phosphoglycoprotein precursor - Homo sapiens (Human) - MEPE gene Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (PubMed:14962809, PubMed:19005008). Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:18162525, PubMed:19998030, PubMed:22766095). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation (PubMed:22341070). Indicus|evm.model.CM009496.1.192 Q28862 SIAL_BOVIN 99.677 0.993569 1.00323 IBSP - Bone sialoprotein 2 precursor - Bos taurus (Bovine) - IBSP gene Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). Indicus|evm.model.CM009496.1.193 P00727 AMPL_BOVIN 99.615 0.996154 1.00193 LAP3 - Cytosol aminopeptidase - Bos taurus (Bovine) - LAP3 gene Cytolosic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides (PubMed:14583094, PubMed:16519517). The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme (PubMed:16519517). For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates (PubMed:16519517). Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status (PubMed:14583094). Indicus|evm.model.CM009496.1.194 Q2TBN4 MED28_BOVIN 98.876 0.988827 1.00562 MED28 - Mediator of RNA polymerase II transcription subunit 28 - Bos taurus (Bovine) - MED28 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity). Indicus|evm.model.CM009496.1.195 Q9ULE4 F184B_HUMAN 82.726 0.998134 1.01132 FAM184B - Protein FAM184B - Homo sapiens (Human) - FAM184B gene Indicus|evm.model.CM009496.1.196 Q9NXF7 DCA16_HUMAN 96.296 0.990783 1.00463 DCAF16 - DDB1- and CUL4-associated factor 16 - Homo sapiens (Human) - DCAF16 gene Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. Indicus|evm.model.CM009496.1.197 Q9BPX3 CND3_HUMAN 88.616 0.998037 1.00394 NCAPG - Condensin complex subunit 3 - Homo sapiens (Human) - NCAPG gene Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Indicus|evm.model.CM009496.1.199 Q8N3X6 LCORL_HUMAN 98.077 0.138207 3.11296 LCORL - Ligand-dependent nuclear receptor corepressor-like protein - Homo sapiens (Human) - LCORL gene May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). Indicus|evm.model.CM009496.1.200 P0DME0 SETLP_HUMAN 80.000 0.333333 0.238411 SETSIP - Protein SETSIP - Homo sapiens (Human) - SETSIP gene Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter. Indicus|evm.model.CM009496.1.202 Q8N7B6 PACRL_HUMAN 89.516 0.991968 1.00403 PACRGL - PACRG-like protein - Homo sapiens (Human) - PACRGL gene Indicus|evm.model.CM009496.1.203 Q2KI69 KCIP4_BOVIN 100.000 0.989796 0.784 KCNIP4 - Kv channel-interacting protein 4 - Bos taurus (Bovine) - KCNIP4 gene Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity). Indicus|evm.model.CM009496.1.204 Q4R5P3 RL10A_MACFA 65.289 0.978261 0.423963 RPL10A - 60S ribosomal protein L10a - Macaca fascicularis (Crab-eating macaque) - RPL10A gene Component of the large ribosomal subunit. Indicus|evm.model.CM009496.1.205 Q8IWK6 AGRA3_HUMAN 96.113 0.986411 0.94701 ADGRA3 - Adhesion G protein-coupled receptor A3 precursor - Homo sapiens (Human) - ADGRA3 gene Orphan receptor that may have a role in planar cell polarity pathway. Indicus|evm.model.CM009496.1.206 Q9H227 GBA3_HUMAN 87.556 0.912602 1.04904 GBA3 - Cytosolic beta-glucosidase - Homo sapiens (Human) - GBA3 gene Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (PubMed:11389701, PubMed:11784319, PubMed:20728381, PubMed:26724485, PubMed:17595169). Has a significant glucosylceramidase activity in vitro (PubMed:26724485, PubMed:17595169). However, that activity is relatively low and its significance in vivo is not clear (PubMed:26724485, PubMed:17595169, PubMed:20728381). Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph (PubMed:17595169). However, the in vivo relevance of these activities is unclear (PubMed:17595169). It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (PubMed:11784319). Could also play a role in the catabolism of cytosolic sialyl free N-glycans (PubMed:26193330). Indicus|evm.model.CM009496.1.207 Q5RCP8 H2B2E_PONAB 87.963 0.981651 0.865079 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009496.1.208 Q865B7 PRGC1_BOVIN 100.000 0.976658 1.02261 PPARGC1A - Peroxisome proliferator-activated receptor gamma coactivator 1-alpha - Bos taurus (Bovine) - PPARGC1A gene Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). Indicus|evm.model.CM009496.1.211 O43143 DHX15_HUMAN 99.748 0.997487 1.00126 DHX15 - Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 - Homo sapiens (Human) - DHX15 gene Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Indicus|evm.model.CM009496.1.212 Q90YR8 RS6_ICTPU 77.551 0.623377 0.309237 rps6 - 40S ribosomal protein S6 - Ictalurus punctatus (Channel catfish) - rps6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009496.1.213 P08294 SODE_HUMAN 79.070 0.764286 1.16667 SOD3 - Extracellular superoxide dismutase [Cu-Zn] precursor - Homo sapiens (Human) - SOD3 gene Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. Indicus|evm.model.CM009496.1.214 Q0VCP9 CC149_BOVIN 82.935 0.510504 1.49216 CCDC149 - Coiled-coil domain-containing protein 149 - Bos taurus (Bovine) - CCDC149 gene Indicus|evm.model.CM009496.1.215 Q1EGL1 LGI2_PANTR 97.248 0.996337 1.00183 LGI2 - Leucine-rich repeat LGI family member 2 precursor - Pan troglodytes (Chimpanzee) - LGI2 gene Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells. Indicus|evm.model.CM009496.1.216 Q9HD40 SPCS_HUMAN 94.534 0.878788 1.11976 SEPSECS - O-phosphoseryl-tRNA(Sec) selenium transferase - Homo sapiens (Human) - SEPSECS gene Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. Indicus|evm.model.CM009496.1.217 Q5ZIK0 P4K2B_CHICK 81.088 0.784836 1.01879 PI4K2B - Phosphatidylinositol 4-kinase type 2-beta - Gallus gallus (Chicken) - PI4K2B gene Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). Indicus|evm.model.CM009496.1.218 E1BGQ2 ZCHC4_BOVIN 99.031 0.996109 0.996124 ZCCHC4 - rRNA N6-adenosine-methyltransferase ZCCHC4 - Bos taurus (Bovine) - ZCCHC4 gene rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation. Indicus|evm.model.CM009496.1.219 Q9UJX5 APC4_HUMAN 97.153 0.997528 1.00124 ANAPC4 - Anaphase-promoting complex subunit 4 - Homo sapiens (Human) - ANAPC4 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Indicus|evm.model.CM009496.1.220 Q27960 NPT2B_BOVIN 99.278 0.985755 1.01299 SLC34A2 - Sodium-dependent phosphate transport protein 2B - Bos taurus (Bovine) - SLC34A2 gene May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli (By similarity). Indicus|evm.model.CM009496.1.221 Q68CR1 SE1L3_HUMAN 92.486 0.982664 0.968198 SEL1L3 - Protein sel-1 homolog 3 - Homo sapiens (Human) - SEL1L3 gene nucleoplasm Indicus|evm.model.CM009496.1.222 Q8N5G0 SIM20_HUMAN 98.214 0.352564 2.32836 SMIM20 - Small integral membrane protein 20 - Homo sapiens (Human) - SMIM20 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (PubMed:26321642). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (PubMed:26321642). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (PubMed:26321642). Indicus|evm.model.CM009496.1.224 Q3SZ41 SUH_BOVIN 100.000 0.995902 1.00205 RBPJ - Recombining binding protein suppressor of hairless - Bos taurus (Bovine) - RBPJ gene Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). Indicus|evm.model.CM009496.1.225 P32238 CCKAR_HUMAN 91.335 0.993007 1.00234 CCKAR - Cholecystokinin receptor type A - Homo sapiens (Human) - CCKAR gene Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009496.1.226 Q8N5T2 TBC19_HUMAN 91.445 0.995927 0.93346 TBC1D19 - TBC1 domain family member 19 - Homo sapiens (Human) - TBC1D19 gene May act as a GTPase-activating protein for Rab family protein(s). Indicus|evm.model.CM009496.1.227 Q9P246 STIM2_HUMAN 95.060 0.894737 1.12064 STIM2 - Stromal interaction molecule 2 precursor - Homo sapiens (Human) - STIM2 gene Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. Indicus|evm.model.CM009496.1.229 A6H767 NP1L1_BOVIN 60.550 0.813725 0.26087 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009496.1.230 A8D8X1 RL10_SHEEP 77.143 0.971963 0.5 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009496.1.233 Q13310 PABP4_HUMAN 73.107 0.955479 0.906832 PABPC4 - Polyadenylate-binding protein 4 - Homo sapiens (Human) - PABPC4 gene Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). Indicus|evm.model.CM009496.1.234 A2VDP2 PCMD1_BOVIN 50.926 0.944444 0.252809 PCMTD1 - Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 - Bos taurus (Bovine) - PCMTD1 gene cytoplasm, protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Indicus|evm.model.CM009496.1.237 Q32L96 PHIPL_BOVIN 91.270 0.976562 0.340426 PHYHIPL - Phytanoyl-CoA hydroxylase interacting protein-like - Bos taurus (Bovine) - PHYHIPL gene May play a role in the development of the central system. Indicus|evm.model.CM009496.1.241 Q8WZ64 ARAP2_HUMAN 82.024 0.996424 0.984742 ARAP2 - Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 - Homo sapiens (Human) - ARAP2 gene Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity). Indicus|evm.model.CM009496.1.243 Q6ZMT9 DTHD1_HUMAN 72.810 0.942278 0.820743 DTHD1 - Death domain-containing protein 1 - Homo sapiens (Human) - DTHD1 gene Indicus|evm.model.CM009496.1.244 Q6ZMT9 DTHD1_HUMAN 85.484 0.473077 0.332907 DTHD1 - Death domain-containing protein 1 - Homo sapiens (Human) - DTHD1 gene Indicus|evm.model.CM009496.1.245 Q99877 H2B1N_HUMAN 90.741 0.981651 0.865079 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009496.1.246 Q6P5U7 NWD2_MOUSE 100.000 0.510417 0.0551091 Nwd2 - NACHT and WD repeat domain-containing protein 2 - Mus musculus (Mouse) - Nwd2 gene Indicus|evm.model.CM009496.1.247 Q9ULI1 NWD2_HUMAN 95.995 0.995703 0.935132 NWD2 - NACHT and WD repeat domain-containing protein 2 - Homo sapiens (Human) - NWD2 gene Indicus|evm.model.CM009496.1.248 Q7T326 CISD2_DANRE 77.419 0.535714 0.414815 cisd2 - CDGSH iron-sulfur domain-containing protein 2 - Danio rerio (Zebrafish) - cisd2 gene Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity). Indicus|evm.model.CM009496.1.249 Q8IY42 CD019_HUMAN 59.502 0.993789 1.02548 C4orf19 - Uncharacterized protein C4orf19 - Homo sapiens (Human) - C4orf19 gene cell junction, nucleoplasm Indicus|evm.model.CM009496.1.250 Q08DP3 RELL1_BOVIN 99.631 0.992647 1.00369 RELL1 - RELT-like protein 1 precursor - Bos taurus (Bovine) - RELL1 gene Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed. Indicus|evm.model.CM009496.1.251 Q5U1W4 LAP4B_RAT 76.154 0.976562 0.563877 Laptm4b - Lysosomal-associated transmembrane protein 4B - Rattus norvegicus (Rat) - Laptm4b gene Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. Indicus|evm.model.CM009496.1.252 Q96G03 PGM2_HUMAN 91.514 0.995025 0.985294 PGM2 - Phosphoglucomutase-2 - Homo sapiens (Human) - PGM2 gene Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity. Indicus|evm.model.CM009496.1.254 O97790 TBCD1_BOVIN 100.000 0.501587 1.08155 TBC1D1 - TBC1 domain family member 1 - Bos taurus (Bovine) - TBC1D1 gene May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). Indicus|evm.model.CM009496.1.257 P57682 KLF3_HUMAN 97.110 0.994236 1.0058 KLF3 - Krueppel-like factor 3 - Homo sapiens (Human) - KLF3 gene Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). Indicus|evm.model.CM009496.1.258 Q6GV17 TLR10_BOVIN 98.969 0.997426 0.956897 TLR10 - Toll-like receptor 10 precursor - Bos taurus (Bovine) - TLR10 gene Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Indicus|evm.model.CM009496.1.259 Q15399 TLR1_HUMAN 78.089 0.988651 1.00891 TLR1 - Toll-like receptor 1 precursor - Homo sapiens (Human) - TLR1 gene Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Indicus|evm.model.CM009496.1.260 Q704V6 TLR6_BOVIN 97.834 0.983689 1.00504 TLR6 - Toll-like receptor 6 precursor - Bos taurus (Bovine) - TLR6 gene Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Indicus|evm.model.CM009496.1.261 Q8IWE2 NXP20_HUMAN 84.192 0.925865 1.07815 FAM114A1 - Protein NOXP20 - Homo sapiens (Human) - FAM114A1 gene May play a role in neuronal cell development. Indicus|evm.model.CM009496.1.262 Q8N614 TM156_HUMAN 73.649 0.784574 1.27027 TMEM156 - Transmembrane protein 156 - Homo sapiens (Human) - TMEM156 gene Indicus|evm.model.CM009496.1.263 Q96PQ7 KLHL5_HUMAN 98.872 0.997183 0.940397 KLHL5 - Kelch-like protein 5 - Homo sapiens (Human) - KLHL5 gene cytoplasm, cytosol, post-translational protein modification Indicus|evm.model.CM009496.1.264 Q8NEZ3 WDR19_HUMAN 91.499 0.997766 1.00075 WDR19 - WD repeat-containing protein 19 - Homo sapiens (Human) - WDR19 gene As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly (PubMed:20889716). Essential for functional IFT-A assembly and ciliary entry of GPCRs (PubMed:20889716). Associates with the BBSome complex to mediate ciliary transport (By similarity). Indicus|evm.model.CM009496.1.265 P35251 RFC1_HUMAN 82.152 0.990018 0.95993 RFC1 - Replication factor C subunit 1 - Homo sapiens (Human) - RFC1 gene The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. Indicus|evm.model.CM009496.1.266 Q86Z14 KLOTB_HUMAN 91.463 0.290284 0.808429 KLB - Beta-klotho - Homo sapiens (Human) - KLB gene Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). Indicus|evm.model.CM009496.1.267 Q3SYR7 RL9_BOVIN 100.000 0.665505 1.49479 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009496.1.268 Q5BIP7 LIAS_BOVIN 99.731 0.994638 1.00269 LIAS - Lipoyl synthase, mitochondrial precursor - Bos taurus (Bovine) - LIAS gene Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. Indicus|evm.model.CM009496.1.269 P12378 UGDH_BOVIN 100.000 0.99596 1.00202 UGDH - UDP-glucose 6-dehydrogenase - Bos taurus (Bovine) - UGDH gene Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (By similarity). Indicus|evm.model.CM009496.1.270 Q2KIK3 SIM14_BOVIN 100.000 0.98 1.0101 SMIM14 - Small integral membrane protein 14 - Bos taurus (Bovine) - SMIM14 gene endoplasmic reticulum Indicus|evm.model.CM009496.1.272 P61087 UBE2K_MOUSE 100.000 0.988889 0.9 Ube2k - Ubiquitin-conjugating enzyme E2 K - Mus musculus (Mouse) - Ube2k gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. Involved in stabilization of CASP12 during ER stress-mediated amyloid-beta neurotoxicity probably by inhibiting proteasome activity; in vitro ubiquitinates CASP12. Indicus|evm.model.CM009496.1.273 Q29RF7 PDS5A_HUMAN 91.724 0.998466 0.975318 PDS5A - Sister chromatid cohesion protein PDS5 homolog A - Homo sapiens (Human) - PDS5A gene Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Indicus|evm.model.CM009496.1.274 Q29RF7 PDS5A_HUMAN 97.872 0.541176 0.0635752 PDS5A - Sister chromatid cohesion protein PDS5 homolog A - Homo sapiens (Human) - PDS5A gene Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Indicus|evm.model.CM009496.1.276 Q86UW6 N4BP2_HUMAN 80.618 0.998869 0.99887 N4BP2 - NEDD4-binding protein 2 - Homo sapiens (Human) - N4BP2 gene Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. Indicus|evm.model.CM009496.1.277 Q2HJG3 RHOH_BOVIN 99.476 0.989583 1.00524 RHOH - Rho-related GTP-binding protein RhoH precursor - Bos taurus (Bovine) - RHOH gene Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils. Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells. Indicus|evm.model.CM009496.1.278 Q9UGM1 ACHA9_HUMAN 94.323 0.991323 0.962422 CHRNA9 - Neuronal acetylcholine receptor subunit alpha-9 precursor - Homo sapiens (Human) - CHRNA9 gene Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840). Indicus|evm.model.CM009496.1.279 A0AV96 RBM47_HUMAN 96.975 0.996622 0.998314 RBM47 - RNA-binding protein 47 - Homo sapiens (Human) - RBM47 gene nucleus, mRNA binding, RNA binding Indicus|evm.model.CM009496.1.280 Q8NE18 NSUN7_HUMAN 80.194 0.995845 1.00557 NSUN7 - Putative methyltransferase NSUN7 - Homo sapiens (Human) - NSUN7 gene May have S-adenosyl-L-methionine-dependent methyl-transferase activity. Indicus|evm.model.CM009496.1.281 Q92870 APBB2_HUMAN 94.071 0.997361 1 APBB2 - Amyloid-beta A4 precursor protein-binding family B member 2 - Homo sapiens (Human) - APBB2 gene May modulate the internalization of amyloid-beta precursor protein. Indicus|evm.model.CM009496.1.283 Q6SEG5 UCHL1_PIG 98.655 0.991071 1.00448 UCHL1 - Ubiquitin carboxyl-terminal hydrolase isozyme L1 precursor - Sus scrofa (Pig) - UCHL1 gene Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity). Indicus|evm.model.CM009496.1.284 Q9UPQ0 LIMC1_HUMAN 93.447 0.871686 0.870729 LIMCH1 - LIM and calponin homology domains-containing protein 1 - Homo sapiens (Human) - LIMCH1 gene Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Indicus|evm.model.CM009496.1.285 O35690 PHX2B_MOUSE 100.000 0.655063 1.00637 Phox2b - Paired mesoderm homeobox protein 2B - Mus musculus (Mouse) - Phox2b gene chromatin, nucleoplasm, nucleus, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, autonomic nervous system development, cell development Indicus|evm.model.CM009496.1.288 P57088 TMM33_HUMAN 97.154 0.987903 1.00405 TMEM33 - Transmembrane protein 33 - Homo sapiens (Human) - TMEM33 gene Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696). Indicus|evm.model.CM009496.1.289 Q6PML9 ZNT9_HUMAN 93.695 0.996473 0.998239 SLC30A9 - Zinc transporter 9 - Homo sapiens (Human) - SLC30A9 gene Acts as a zinc transporter involved in intracellular zinc homeostasis (PubMed:28334855). Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (By similarity). Indicus|evm.model.CM009496.1.290 Q6ZU67 BEND4_HUMAN 91.481 0.996283 1.00749 BEND4 - BEN domain-containing protein 4 - Homo sapiens (Human) - BEND4 gene Indicus|evm.model.CM009496.1.292 A0PJX4 SHSA3_HUMAN 95.982 0.933054 1.0042 SHISA3 - Protein shisa-3 homolog precursor - Homo sapiens (Human) - SHISA3 gene Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Indicus|evm.model.CM009496.1.293 P70704 AT8A1_MOUSE 88.991 0.586957 0.158076 Atp8a1 - Phospholipid-transporting ATPase IA - Mus musculus (Mouse) - Atp8a1 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:20224745, PubMed:16618126). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:20224745, PubMed:16618126). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane (PubMed:23269685). Acts as aminophospholipid translocase at the plasma membrane in neuronal cells; the activity is associated with hippocampus-dependent learning (PubMed:22007859). May play a role in brain connectivity (PubMed:27287255). Indicus|evm.model.CM009496.1.294 Q29449 AT8A1_BOVIN 97.867 0.976825 0.751088 ATP8A1 - Probable phospholipid-transporting ATPase IA - Bos taurus (Bovine) - ATP8A1 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (By similarity). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (By similarity). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane (By similarity). Acts as aminophospholipid translocase at the plasma membrane in neuronal cells (By similarity). Indicus|evm.model.CM009496.1.296 Q5RB63 HTSF1_PONAB 76.299 0.962389 0.599469 HTATSF1 - HIV Tat-specific factor 1 homolog - Pongo abelii (Sumatran orangutan) - HTATSF1 gene Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation (By similarity). Indicus|evm.model.CM009496.1.298 Q9BUJ2 HNRL1_HUMAN 86.364 0.988701 0.206776 HNRNPUL1 - Heterogeneous nuclear ribonucleoprotein U-like protein 1 - Homo sapiens (Human) - HNRNPUL1 gene Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. Indicus|evm.model.CM009496.1.300 Q6ZWB6 KCTD8_HUMAN 96.154 0.922619 0.35518 KCTD8 - BTB/POZ domain-containing protein KCTD8 - Homo sapiens (Human) - KCTD8 gene Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). Indicus|evm.model.CM009496.1.301 Q6ZWB6 KCTD8_HUMAN 96.262 0.960606 0.697674 KCTD8 - BTB/POZ domain-containing protein KCTD8 - Homo sapiens (Human) - KCTD8 gene Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). Indicus|evm.model.CM009496.1.302 A5D7K7 YIPF7_BOVIN 95.686 0.927757 1.03137 YIPF7 - Protein YIPF7 - Bos taurus (Bovine) - YIPF7 gene Indicus|evm.model.CM009496.1.303 A6QLJ3 GUF1_BOVIN 100.000 0.889481 1.12257 GUF1 - Translation factor GUF1, mitochondrial precursor - Bos taurus (Bovine) - GUF1 gene Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Indicus|evm.model.CM009496.1.304 Q17QL1 GNPI2_BOVIN 100.000 0.804094 1.23913 GNPDA2 - Glucosamine-6-phosphate isomerase 2 - Bos taurus (Bovine) - GNPDA2 gene cytoplasm, glucosamine-6-phosphate deaminase activity, identical protein binding, glucosamine catabolic process, N-acetylglucosamine catabolic process, N-acetylneuraminate catabolic process, UDP-N-acetylglucosamine biosynthetic process Indicus|evm.model.CM009496.1.306 P23574 GBRG1_RAT 97.093 0.971671 0.75914 Gabrg1 - Gamma-aminobutyric acid receptor subunit gamma-1 precursor - Rattus norvegicus (Rat) - Gabrg1 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Indicus|evm.model.CM009496.1.307 Q5RCC5 GBRA2_PONAB 100.000 0.985294 0.452328 GABRA2 - Gamma-aminobutyric acid receptor subunit alpha-2 precursor - Pongo abelii (Sumatran orangutan) - GABRA2 gene Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Indicus|evm.model.CM009496.1.308 Q5E995 RS6_BOVIN 89.474 0.711538 0.208835 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009496.1.309 Q6WV90 H4_MYTGA 99.029 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009496.1.310 P20237 GBRA4_BOVIN 100.000 0.996403 1.0018 GABRA4 - Gamma-aminobutyric acid receptor subunit alpha-4 precursor - Bos taurus (Bovine) - GABRA4 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Indicus|evm.model.CM009496.1.312 P08220 GBRB1_BOVIN 97.885 0.955621 0.71308 GABRB1 - Gamma-aminobutyric acid receptor subunit beta-1 precursor - Bos taurus (Bovine) - GABRB1 gene Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. Indicus|evm.model.CM009496.1.313 Q9NX08 COMD8_HUMAN 83.607 0.98913 1.00546 COMMD8 - COMM domain-containing protein 8 - Homo sapiens (Human) - COMMD8 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Indicus|evm.model.CM009496.1.314 Q9P241 AT10D_HUMAN 85.386 0.990991 1.01192 ATP10D - Phospholipid-transporting ATPase VD - Homo sapiens (Human) - ATP10D gene Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. Indicus|evm.model.CM009496.1.315 Q9Y5Q5 CORIN_HUMAN 74.661 0.984544 0.620921 CORIN - Atrial natriuretic peptide-converting enzyme - Homo sapiens (Human) - CORIN gene Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity). Indicus|evm.model.CM009496.1.316 Q9Y5Q5 CORIN_HUMAN 69.912 0.835821 0.128599 CORIN - Atrial natriuretic peptide-converting enzyme - Homo sapiens (Human) - CORIN gene Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity). Indicus|evm.model.CM009496.1.317 Q6ZNB6 NFXL1_HUMAN 92.114 0.997768 0.983535 NFXL1 - NF-X1-type zinc finger protein NFXL1 - Homo sapiens (Human) - NFXL1 gene chromatin, membrane, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, regulation of transcription, DNA-templated Indicus|evm.model.CM009496.1.318 Q00194 CNGA1_BOVIN 99.420 0.997106 1.00145 CNGA1 - cGMP-gated cation channel alpha-1 - Bos taurus (Bovine) - CNGA1 gene Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. Indicus|evm.model.CM009496.1.319 Q6NVV3 NIPA3_HUMAN 88.235 0.985472 1.00732 NIPAL1 - Magnesium transporter NIPA3 - Homo sapiens (Human) - NIPAL1 gene Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). Indicus|evm.model.CM009496.1.320 P42681 TXK_HUMAN 88.994 0.996212 1.0019 TXK - Tyrosine-protein kinase TXK - Homo sapiens (Human) - TXK gene Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976). Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976). Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. Indicus|evm.model.CM009496.1.321 P42680 TEC_HUMAN 95.735 0.792714 1.26149 TEC - Tyrosine-protein kinase Tec - Homo sapiens (Human) - TEC gene Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. Indicus|evm.model.CM009496.1.322 Q3MHV6 SLAI2_BOVIN 100.000 0.907816 0.857388 SLAIN2 - SLAIN motif-containing protein 2 - Bos taurus (Bovine) - SLAIN2 gene Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase (By similarity). Indicus|evm.model.CM009496.1.323 Q96EP9 NTCP4_HUMAN 86.041 0.971047 1.02746 SLC10A4 - Sodium/bile acid cotransporter 4 - Homo sapiens (Human) - SLC10A4 gene Transporter for bile acids. Indicus|evm.model.CM009496.1.324 Q1XFL1 ZAR1L_BOVIN 65.385 0.217647 1.06918 ZAR1L - ZAR1-like protein - Bos taurus (Bovine) - ZAR1L gene cytoplasm, mRNA binding involved in posttranscriptional gene silencing, translation Indicus|evm.model.CM009496.1.325 O94915 FRYL_HUMAN 95.427 0.999332 0.993362 FRYL - Protein furry homolog-like - Homo sapiens (Human) - FRYL gene Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. Indicus|evm.model.CM009496.1.326 Q5E948 OCAD1_BOVIN 100.000 0.991935 1.00405 Ociad1 - OCIA domain-containing protein 1 - Bos taurus (Bovine) - Ociad1 gene Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Indicus|evm.model.CM009496.1.327 Q3SYY7 OCAD2_BOVIN 100.000 0.987097 1.00649 OCIAD2 - OCIA domain-containing protein 2 - Bos taurus (Bovine) - OCIAD2 gene Indicus|evm.model.CM009496.1.328 Q9H720 PG2IP_HUMAN 85.408 0.997143 1.00143 CWH43 - PGAP2-interacting protein - Homo sapiens (Human) - CWH43 gene Involved in lipid remodeling during GPI-anchor maturation. Indicus|evm.model.CM009496.1.329 Q92564 DCNL4_HUMAN 98.973 0.993174 1.00342 DCUN1D4 - DCN1-like protein 4 - Homo sapiens (Human) - DCUN1D4 gene Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). Indicus|evm.model.CM009496.1.330 Q68CR7 LRC66_HUMAN 55.800 0.994033 0.952273 LRRC66 - Leucine-rich repeat-containing protein 66 - Homo sapiens (Human) - LRRC66 gene Indicus|evm.model.CM009496.1.331 A6QP70 SGCB_BOVIN 98.653 0.993289 0.940063 SGCB - Beta-sarcoglycan - Bos taurus (Bovine) - SGCB gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Indicus|evm.model.CM009496.1.332 E1BLK7 MIEAP_BOVIN 96.230 0.996416 1.03911 SPATA18 - Mitochondria-eating protein - Bos taurus (Bovine) - SPATA18 gene Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Indicus|evm.model.CM009496.1.333 Q5RBQ4 UBP46_PONAB 99.162 0.991667 0.983607 USP46 - Ubiquitin carboxyl-terminal hydrolase 46 - Pongo abelii (Sumatran orangutan) - USP46 gene Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity). Indicus|evm.model.CM009496.1.334 Q5E9J3 RSLBB_BOVIN 100.000 0.991968 1.00403 RASL11B - Ras-like protein family member 11B - Bos taurus (Bovine) - RASL11B gene Indicus|evm.model.CM009496.1.335 Q8WU76 SCFD2_HUMAN 87.785 0.998371 0.897661 SCFD2 - Sec1 family domain-containing protein 2 - Homo sapiens (Human) - SCFD2 gene May be involved in protein transport. Indicus|evm.model.CM009496.1.336 Q5RAA7 FIP1_PONAB 92.308 0.553971 0.835034 FIP1L1 - Pre-mRNA 3'-end-processing factor FIP1 - Pongo abelii (Sumatran orangutan) - FIP1L1 gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity). Indicus|evm.model.CM009496.1.337 Q8TBB1 LNX1_HUMAN 88.115 0.997268 1.00549 LNX1 - E3 ubiquitin-protein ligase LNX - Homo sapiens (Human) - LNX1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Indicus|evm.model.CM009496.1.338 Q9UKJ5 CHIC2_HUMAN 100.000 0.987952 1.00606 CHIC2 - Cysteine-rich hydrophobic domain-containing protein 2 - Homo sapiens (Human) - CHIC2 gene Golgi-associated vesicle, intracellular membrane-bounded organelle, plasma membrane Indicus|evm.model.CM009496.1.339 Q9BZM3 GSX2_HUMAN 92.787 0.819407 1.22039 GSX2 - GS homeobox 2 - Homo sapiens (Human) - GSX2 gene Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development (PubMed:31412107). During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Indicus|evm.model.CM009496.1.340 P16234 PGFRA_HUMAN 94.123 0.998165 1.00092 PDGFRA - Platelet-derived growth factor receptor alpha precursor - Homo sapiens (Human) - PDGFRA gene Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. Indicus|evm.model.CM009496.1.341 P43481 KIT_BOVIN 99.591 0.997947 0.996929 KIT - Mast/stem cell growth factor receptor Kit precursor - Bos taurus (Bovine) - KIT gene Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity). Indicus|evm.model.CM009496.1.342 P35968 VGFR2_HUMAN 91.077 0.998526 1.00074 KDR - Vascular endothelial growth factor receptor 2 precursor - Homo sapiens (Human) - KDR gene Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. Indicus|evm.model.CM009496.1.343 D2HBV9 PORED_AILME 95.349 0.408654 0.654088 SRD5A3 - Polyprenol reductase - Ailuropoda melanoleuca (Giant panda) - SRD5A3 gene Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity). Indicus|evm.model.CM009496.1.344 Q9HC07 TM165_HUMAN 95.370 0.993846 1.00309 TMEM165 - Transmembrane protein 165 precursor - Homo sapiens (Human) - TMEM165 gene May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation. Indicus|evm.model.CM009496.1.345 O15516 CLOCK_HUMAN 96.930 0.997636 1 CLOCK - Circadian locomoter output cycles protein kaput - Homo sapiens (Human) - CLOCK gene Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner ARNTL/BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). Indicus|evm.model.CM009496.1.346 Q32LN3 PDCL2_BOVIN 100.000 0.663889 1.4876 PDCL2 - Phosducin-like protein 2 - Bos taurus (Bovine) - PDCL2 gene Indicus|evm.model.CM009496.1.347 P60982 DEST_PIG 85.000 0.940476 0.509091 DSTN - Destrin - Sus scrofa (Pig) - DSTN gene Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. Indicus|evm.model.CM009496.1.348 Q9NV70 EXOC1_HUMAN 98.770 0.997765 1.00112 EXOC1 - Exocyst complex component 1 - Homo sapiens (Human) - EXOC1 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Indicus|evm.model.CM009496.1.349 Q66GS9 CP135_HUMAN 88.235 0.998246 1 CEP135 - Centrosomal protein of 135 kDa - Homo sapiens (Human) - CEP135 gene Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). Indicus|evm.model.CM009496.1.350 Q6ZU35 CRACD_HUMAN 81.457 0.205321 1.18897 CRACD - Capping protein-inhibiting regulator of actin dynamics - Homo sapiens (Human) - CRACD gene Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. Indicus|evm.model.CM009496.1.351 Q4L235 ACSF4_HUMAN 83.545 0.969109 1.03188 AASDH - Beta-alanine-activating enzyme - Homo sapiens (Human) - AASDH gene Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA. Indicus|evm.model.CM009496.1.352 Q06203 PUR1_HUMAN 88.819 0.995781 0.916828 PPAT - Amidophosphoribosyltransferase precursor - Homo sapiens (Human) - PPAT gene cytosol, amidophosphoribosyltransferase activity, purine nucleotide biosynthetic process, purine ribonucleoside monophosphate biosynthetic process Indicus|evm.model.CM009496.1.353 Q5RB59 PUR6_PONAB 94.824 0.490173 2.03529 PAICS - Multifunctional protein ADE2 - Pongo abelii (Sumatran orangutan) - PAICS gene Indicus|evm.model.CM009496.1.354 P33731 SRP72_CANLF 97.765 0.997024 1.00149 SRP72 - Signal recognition particle subunit SRP72 - Canis lupus familiaris (Dog) - SRP72 gene Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. Indicus|evm.model.CM009496.1.355 Q6T311 ARL9_HUMAN 85.795 0.553797 1.68984 ARL9 - ADP-ribosylation factor-like protein 9 - Homo sapiens (Human) - ARL9 gene Indicus|evm.model.CM009496.1.356 Q5PQR6 THEGL_RAT 65.350 0.713974 1.00881 Thegl - Testicular haploid expressed gene protein-like - Rattus norvegicus (Rat) - Thegl gene Indicus|evm.model.CM009496.1.357 P62282 RS11_RAT 72.152 0.742857 1.32911 Rps11 - 40S ribosomal protein S11 - Rattus norvegicus (Rat) - Rps11 gene cytosolic small ribosomal subunit, membrane, structural constituent of ribosome, osteoblast differentiation Indicus|evm.model.CM009496.1.358 P20155 ISK2_HUMAN 77.049 0.697674 1.02381 SPINK2 - Serine protease inhibitor Kazal-type 2 precursor - Homo sapiens (Human) - SPINK2 gene As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin. Indicus|evm.model.CM009496.1.359 Q13127 REST_HUMAN 69.946 0.969815 0.93619 REST - RE1-silencing transcription factor - Homo sapiens (Human) - REST gene Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247, PubMed:11741002, PubMed:11779185). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). Indicus|evm.model.CM009496.1.360 Q32LB9 NOA1_BOVIN 70.681 0.873016 0.272334 NOA1 - Nitric oxide-associated protein 1 - Bos taurus (Bovine) - NOA1 gene Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP (By similarity). Indicus|evm.model.CM009496.1.361 P20155 ISK2_HUMAN 70.000 0.544444 1.07143 SPINK2 - Serine protease inhibitor Kazal-type 2 precursor - Homo sapiens (Human) - SPINK2 gene As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin. Indicus|evm.model.CM009496.1.362 O54963 REST_RAT 64.940 0.99801 0.940131 Rest - RE1-silencing transcription factor - Rattus norvegicus (Rat) - Rest gene Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (By similarity). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (By similarity). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (PubMed:9454838). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (By similarity). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 6 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 6, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (By similarity). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult hippocampal neural stem cells and preventing premature differentiation into mature neurons (By similarity). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (PubMed:22960932). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (By similarity). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (By similarity). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (PubMed:22371606, PubMed:12657670). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (PubMed:25108103). Indicus|evm.model.CM009496.1.363 Q32LB9 NOA1_BOVIN 99.280 0.946721 1.05476 NOA1 - Nitric oxide-associated protein 1 - Bos taurus (Bovine) - NOA1 gene Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP (By similarity). Indicus|evm.model.CM009496.1.364 P30876 RPB2_HUMAN 99.915 0.998298 1.00085 POLR2B - DNA-directed RNA polymerase II subunit RPB2 - Homo sapiens (Human) - POLR2B gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity). Indicus|evm.model.CM009496.1.365 Q16270 IBP7_HUMAN 97.980 0.98995 0.705674 IGFBP7 - Insulin-like growth factor-binding protein 7 precursor - Homo sapiens (Human) - IGFBP7 gene Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Indicus|evm.model.CM009496.1.369 Q0II59 PDXK_BOVIN 74.286 0.404762 0.269231 PDXK - Pyridoxal kinase - Bos taurus (Bovine) - PDXK gene Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity). Indicus|evm.model.CM009496.1.370 P54277 PMS1_HUMAN 79.100 0.910543 0.335837 PMS1 - PMS1 protein homolog 1 - Homo sapiens (Human) - PMS1 gene Probably involved in the repair of mismatches in DNA. Indicus|evm.model.CM009496.1.371 P62856 RS26_RAT 94.681 0.978947 0.826087 Rps26 - 40S ribosomal protein S26 - Rattus norvegicus (Rat) - Rps26 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, mRNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009496.1.372 Q3SZ89 TECRL_BOVIN 99.725 0.994505 1.00275 TECRL - Trans-2,3-enoyl-CoA reductase-like - Bos taurus (Bovine) - TECRL gene oxidoreductase activity, very long-chain fatty acid biosynthetic process Indicus|evm.model.CM009496.1.373 Q86YF9 DZIP1_HUMAN 73.810 0.942966 0.303345 DZIP1 - Zinc finger protein DZIP1 - Homo sapiens (Human) - DZIP1 gene May participate in spermatogenesis via its interaction with DAZ1 (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954). Indicus|evm.model.CM009496.1.374 P54756 EPHA5_HUMAN 97.517 0.997745 0.855352 EPHA5 - Ephrin type-A receptor 5 precursor - Homo sapiens (Human) - EPHA5 gene Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). Indicus|evm.model.CM009496.1.376 P49453 CENPC_SHEEP 86.500 0.412262 2.35323 CENPC - Centromere protein C - Ovis aries (Sheep) - CENPC gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. Indicus|evm.model.CM009496.1.377 Q9ULZ2 STAP1_HUMAN 87.273 0.948097 0.979661 STAP1 - Signal-transducing adaptor protein 1 - Homo sapiens (Human) - STAP1 gene In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. Indicus|evm.model.CM009496.1.378 A0AVT1 UBA6_HUMAN 92.015 0.993384 1.0057 UBA6 - Ubiquitin-like modifier-activating enzyme 6 - Homo sapiens (Human) - UBA6 gene Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Indicus|evm.model.CM009496.1.379 P32236 GNRHR_BOVIN 99.695 0.993921 1.00305 GNRHR - Gonadotropin-releasing hormone receptor - Bos taurus (Bovine) - GNRHR gene Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009496.1.380 Q1JRP2 TM11C_MOUSE 69.660 0.992327 0.907193 Tmprss11c - Transmembrane protease serine 11C precursor - Mus musculus (Mouse) - Tmprss11c gene Serine protease which has a preference for Arg or Lys in position P1 and uncharged residues in positions P2 and P3. Shows specificity towards FGF2 in vitro. Indicus|evm.model.CM009496.1.381 O60235 TM11D_HUMAN 70.913 0.898048 1.10287 TMPRSS11D - Transmembrane protease serine 11D precursor - Homo sapiens (Human) - TMPRSS11D gene May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. Indicus|evm.model.CM009496.1.382 Q6ZMR5 TM11A_HUMAN 78.095 0.995215 0.992874 TMPRSS11A - Transmembrane protease serine 11A - Homo sapiens (Human) - TMPRSS11A gene Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest. Indicus|evm.model.CM009496.1.383 Q8BZ10 TM11G_MOUSE 74.708 0.992248 0.618705 Tmprss11g - Transmembrane protease serine 11G precursor - Mus musculus (Mouse) - Tmprss11g gene plasma membrane Indicus|evm.model.CM009496.1.384 Q6ZWK6 TM11F_HUMAN 81.977 0.907162 0.860731 TMPRSS11F - Transmembrane protease serine 11F - Homo sapiens (Human) - TMPRSS11F gene Probable serine protease. Indicus|evm.model.CM009496.1.385 Q14C59 TM11B_MOUSE 77.404 0.995204 1.0024 Tmprss11b - Transmembrane protease serine 11B-like protein - Mus musculus (Mouse) - Tmprss11b gene Serine protease. Indicus|evm.model.CM009496.1.386 A6H767 NP1L1_BOVIN 99.488 0.994898 1.00256 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009496.1.387 Q86T26 TM11B_HUMAN 62.500 0.894309 0.887019 TMPRSS11B - Transmembrane protease serine 11B - Homo sapiens (Human) - TMPRSS11B gene Serine protease. Indicus|evm.model.CM009496.1.388 Q9UL52 TM11E_HUMAN 81.280 0.995272 1 TMPRSS11E - Transmembrane protease serine 11E precursor - Homo sapiens (Human) - TMPRSS11E gene Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. Indicus|evm.model.CM009496.1.390 Q96MU7 YTDC1_HUMAN 96.201 0.997286 1.01376 YTHDC1 - YTH domain-containing protein 1 - Homo sapiens (Human) - YTHDC1 gene Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). Indicus|evm.model.CM009496.1.391 Q91XL9 OSBL1_MOUSE 95.366 0.995134 0.432632 Osbpl1a - Oxysterol-binding protein-related protein 1 - Mus musculus (Mouse) - Osbpl1a gene Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol. Indicus|evm.model.CM009496.1.392 Q6K1J1 UDB31_CANLF 74.340 0.990602 1.00377 UGT2B31 - UDP-glucuronosyltransferase 2B31 precursor - Canis lupus familiaris (Dog) - UGT2B31 gene UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs. Indicus|evm.model.CM009496.1.393 Q6K1J1 UDB31_CANLF 76.181 0.990602 1.00377 UGT2B31 - UDP-glucuronosyltransferase 2B31 precursor - Canis lupus familiaris (Dog) - UGT2B31 gene UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs. Indicus|evm.model.CM009496.1.394 P06133 UD2B4_HUMAN 74.669 0.996226 1.00379 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Indicus|evm.model.CM009496.1.395 P06133 UD2B4_HUMAN 73.624 0.986395 0.835227 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Indicus|evm.model.CM009496.1.396 P06133 UD2B4_HUMAN 75.614 0.990619 1.00947 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Indicus|evm.model.CM009496.1.397 P06133 UD2B4_HUMAN 74.669 0.996226 1.00379 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Indicus|evm.model.CM009496.1.398 P06133 UD2B4_HUMAN 75.800 0.797125 1.18561 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Indicus|evm.model.CM009496.1.399 P06133 UD2B4_HUMAN 58.594 0.956427 0.869318 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Indicus|evm.model.CM009496.1.400 P06133 UD2B4_HUMAN 74.624 0.996248 1.00947 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Indicus|evm.model.CM009496.1.401 P36514 UD2C1_RABIT 69.277 0.932099 0.968127 UGT2C1 - UDP-glucuronosyltransferase 2C1 - Oryctolagus cuniculus (Rabbit) - UGT2C1 gene UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Indicus|evm.model.CM009496.1.402 P36514 UD2C1_RABIT 74.743 0.505723 1.91434 UGT2C1 - UDP-glucuronosyltransferase 2C1 - Oryctolagus cuniculus (Rabbit) - UGT2C1 gene UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Indicus|evm.model.CM009496.1.403 P36514 UD2C1_RABIT 74.498 0.937736 1.05578 UGT2C1 - UDP-glucuronosyltransferase 2C1 - Oryctolagus cuniculus (Rabbit) - UGT2C1 gene UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Indicus|evm.model.CM009496.1.404 P36514 UD2C1_RABIT 74.148 0.939623 1.05578 UGT2C1 - UDP-glucuronosyltransferase 2C1 - Oryctolagus cuniculus (Rabbit) - UGT2C1 gene UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Indicus|evm.model.CM009496.1.405 O94966 UBP19_HUMAN 70.000 0.576471 0.0644917 USP19 - Ubiquitin carboxyl-terminal hydrolase 19 - Homo sapiens (Human) - USP19 gene Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. Indicus|evm.model.CM009496.1.406 Q9R110 UD2A3_CAVPO 75.285 0.990566 1 UGT2A3 - UDP-glucuronosyltransferase 2A3 precursor - Cavia porcellus (Guinea pig) - UGT2A3 gene UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). Indicus|evm.model.CM009496.1.407 P0DTE4 UD2A1_HUMAN 87.917 0.967611 0.468691 UGT2A1 - UDP-glucuronosyltransferase 2A1 precursor - Homo sapiens (Human) - UGT2A1 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10359671, PubMed:19858781, PubMed:18719240, PubMed:19022937, PubMed:23756265, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:10359671, PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone and epitestosterone) and estrogens (estradiol and epiestriol) (PubMed:18719240, PubMed:19858781, PubMed:19022937, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction (PubMed:10359671). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781). Indicus|evm.model.CM009496.1.408 Q3T0Y3 ST1B1_BOVIN 100.000 0.993266 1.00338 SULT1B1 - Sulfotransferase family cytosolic 1B member 1 - Bos taurus (Bovine) - SULT1B1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine (By similarity). Indicus|evm.model.CM009496.1.409 G3V9R3 ST1D1_RAT 81.159 0.975177 0.955932 Sult1d1 - Sulfotransferase 1 family member D1 - Rattus norvegicus (Rat) - Sult1d1 gene Sulfotransferase with broad substrate specificity that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, such as dopamine, prostaglandins, leukotriene E4, drugs and xenobiotic compounds. Has sulfotransferase activity towards p-nitrophenol, 2-naphthylamine and minoxidil (in vitro). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites (By similarity). Indicus|evm.model.CM009496.1.410 P19217 ST1E1_BOVIN 99.322 0.993243 1.00339 SULT1E1 - Sulfotransferase 1E1 - Bos taurus (Bovine) - SULT1E1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:1900200) (By similarity). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). Indicus|evm.model.CM009496.1.411 O15381 NVL_HUMAN 80.816 0.579088 0.435748 NVL - Nuclear valosin-containing protein-like - Homo sapiens (Human) - NVL gene Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111). Indicus|evm.model.CM009496.1.412 P02666 CASB_BOVIN 100.000 0.944915 1.05357 CSN2 - Beta-casein precursor - Bos taurus (Bovine) - CSN2 gene Important role in determination of the surface properties of the casein micelles. Indicus|evm.model.CM009496.1.413 P02663 CASA2_BOVIN 90.640 0.485488 1.70721 CSN1S2 - Alpha-S2-casein precursor - Bos taurus (Bovine) - CSN1S2 gene Important role in the capacity of milk to transport calcium phosphate. Indicus|evm.model.CM009496.1.414 A1YQ93 ODAM_BOVIN 99.242 0.992453 0.956679 ODAM - Odontogenic ameloblast-associated protein precursor - Bos taurus (Bovine) - ODAM gene Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. Indicus|evm.model.CM009496.1.419 Q2TBJ9 CABS1_BOVIN 99.485 0.979747 1.01804 CABS1 - Calcium-binding and spermatid-specific protein 1 - Bos taurus (Bovine) - CABS1 gene Calcium-binding protein (By similarity). Essential for maintaining the structural integrity of the sperm flagella (By similarity). Indicus|evm.model.CM009496.1.421 P55859 PNPH_BOVIN 95.139 0.989655 1.00346 PNP - Purine nucleoside phosphorylase - Bos taurus (Bovine) - PNP gene Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity). Indicus|evm.model.CM009496.1.423 Q6UX39 AMTN_HUMAN 70.142 0.859504 1.15789 AMTN - Amelotin precursor - Homo sapiens (Human) - AMTN gene Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Indicus|evm.model.CM009496.1.424 O43683 BUB1_HUMAN 77.044 0.963415 0.302304 BUB1 - Mitotic checkpoint serine/threonine-protein kinase BUB1 - Homo sapiens (Human) - BUB1 gene Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. Indicus|evm.model.CM009496.1.425 Q9XSX7 AMBN_BOVIN 92.891 0.983645 1.09184 AMBN - Ameloblastin precursor - Bos taurus (Bovine) - AMBN gene Involved in the mineralization and structural organization of enamel. Indicus|evm.model.CM009496.1.426 O97939 ENAM_PIG 77.720 0.998255 1.0035 ENAM - Enamelin precursor - Sus scrofa (Pig) - ENAM gene Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. Indicus|evm.model.CM009496.1.427 P0DUB2 IGJ_EQUAS 80.380 0.987342 1 JCHAIN - Immunoglobulin J chain precursor - Equus asinus (Donkey) - JCHAIN gene Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component. Indicus|evm.model.CM009496.1.428 Q9NQZ2 SAS10_HUMAN 86.071 0.995789 0.991649 UTP3 - Something about silencing protein 10 - Homo sapiens (Human) - UTP3 gene Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Indicus|evm.model.CM009496.1.429 Q7L099 RUFY3_HUMAN 98.961 0.563877 1.45203 RUFY3 - Protein RUFY3 - Homo sapiens (Human) - RUFY3 gene Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321). Indicus|evm.model.CM009496.1.430 Q12849 GRSF1_HUMAN 95.014 0.991736 0.75625 GRSF1 - G-rich sequence factor 1 precursor - Homo sapiens (Human) - GRSF1 gene Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). Indicus|evm.model.CM009496.1.431 Q8BPB0 MOB1B_MOUSE 100.000 0.990783 1.00463 Mob1b - MOB kinase activator 1B - Mus musculus (Mouse) - Mob1b gene Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L (By similarity). Indicus|evm.model.CM009496.1.432 Q3MHR2 DCK_BOVIN 100.000 0.980545 0.988462 DCK - Deoxycytidine kinase - Bos taurus (Bovine) - DCK gene Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine. Indicus|evm.model.CM009496.1.433 Q9GL77 S4A4_BOVIN 99.710 0.907652 1.05375 SLC4A4 - Electrogenic sodium bicarbonate cotransporter 1 - Bos taurus (Bovine) - SLC4A4 gene Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Indicus|evm.model.CM009496.1.434 P19378 HSP7C_CRIGR 90.667 0.258741 0.442724 HSPA8 - Heat shock cognate 71 kDa protein - Cricetulus griseus (Chinese hamster) - HSPA8 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Interacts with VGF-derived peptide TLQP-21. Indicus|evm.model.CM009496.1.435 Q3MHN5 VTDB_BOVIN 87.774 0.699095 0.932489 GC - Vitamin D-binding protein precursor - Bos taurus (Bovine) - GC gene Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. Indicus|evm.model.CM009496.1.436 Q3MHN5 VTDB_BOVIN 98.734 0.987421 0.335443 GC - Vitamin D-binding protein precursor - Bos taurus (Bovine) - GC gene Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. Indicus|evm.model.CM009496.1.437 Q9Y5X5 NPFF2_HUMAN 84.539 0.993443 0.584291 NPFFR2 - Neuropeptide FF receptor 2 - Homo sapiens (Human) - NPFFR2 gene Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009496.1.438 O15072 ATS3_HUMAN 93.284 0.998337 0.99834 ADAMTS3 - A disintegrin and metalloproteinase with thrombospondin motifs 3 precursor - Homo sapiens (Human) - ADAMTS3 gene Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens. Indicus|evm.model.CM009496.1.439 Q8N8Q8 COX18_HUMAN 81.602 0.982456 1.02703 COX18 - Cytochrome c oxidase assembly protein COX18, mitochondrial precursor - Homo sapiens (Human) - COX18 gene Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). Indicus|evm.model.CM009496.1.440 O75179 ANR17_HUMAN 98.391 0.994 0.96043 ANKRD17 - Ankyrin repeat domain-containing protein 17 - Homo sapiens (Human) - ANKRD17 gene Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). Indicus|evm.model.CM009496.1.442 G3MYZ3 AFAM_BOVIN 99.655 0.344643 2.78146 AFM - Afamin precursor - Bos taurus (Bovine) - AFM gene Functions as carrier for hydrophobic molecules in body fluids. Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B (PubMed:26902720). Binds vitamin E. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the transport of vitamin E across the blood-brain barrier (By similarity). Indicus|evm.model.CM009496.1.444 Q6ZTQ3 RASF6_HUMAN 81.790 0.856764 1.02168 RASSF6 - Ras association domain-containing protein 6 - Homo sapiens (Human) - RASSF6 gene Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). Indicus|evm.model.CM009496.1.445 P79255 IL8_BOVIN 99.010 0.980392 1.0099 CXCL8 - Interleukin-8 precursor - Bos taurus (Bovine) - CXCL8 gene IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). Indicus|evm.model.CM009496.1.446 Q9H0P0 5NT3A_HUMAN 91.018 0.917355 1.08036 NT5C3A - Cytosolic 5'-nucleotidase 3A - Homo sapiens (Human) - NT5C3A gene Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458). Indicus|evm.model.CM009496.1.447 P80221 CXCL6_BOVIN 100.000 0.982301 1.00893 CXCL6 - C-X-C motif chemokine 6 precursor - Bos taurus (Bovine) - CXCL6 gene Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7) (By similarity). Indicus|evm.model.CM009496.1.448 P02777 PLF4_BOVIN 93.151 0.243243 3.36364 PF4 - Platelet factor 4 - Bos taurus (Bovine) - PF4 gene Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation. Indicus|evm.model.CM009496.1.449 O46677 GROB_BOVIN 100.000 0.339506 1.55769 Growth-regulated protein homolog beta precursor - Bos taurus (Bovine) Indicus|evm.model.CM009496.1.450 O46675 GROG_BOVIN 89.474 0.895238 1.07143 Growth-regulated protein homolog gamma precursor - Bos taurus (Bovine) Indicus|evm.model.CM009496.1.451 O46677 GROB_BOVIN 96.154 0.980952 1.00962 Growth-regulated protein homolog beta precursor - Bos taurus (Bovine) Indicus|evm.model.CM009496.1.452 Q9H903 MTD2L_HUMAN 78.386 0.993485 0.884726 MTHFD2L - Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 - Homo sapiens (Human) - MTHFD2L gene mitochondrial matrix, mitochondrion, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, folic acid metabolic process, tetrahydrofolate interconversion Indicus|evm.model.CM009496.1.453 Q6UW88 EPGN_HUMAN 90.000 0.721212 1.07143 EPGN - Epigen precursor - Homo sapiens (Human) - EPGN gene Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. Indicus|evm.model.CM009496.1.454 O14944 EREG_HUMAN 86.503 0.987805 0.970414 EREG - Proepiregulin precursor - Homo sapiens (Human) - EREG gene Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). Indicus|evm.model.CM009496.1.455 P15514 AREG_HUMAN 77.470 0.991935 0.984127 AREG - Amphiregulin precursor - Homo sapiens (Human) - AREG gene Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. Indicus|evm.model.CM009496.1.456 Q9TTC5 BTC_BOVIN 99.438 0.988827 1.00562 BTC - Probetacellulin precursor - Bos taurus (Bovine) - BTC gene Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). Indicus|evm.model.CM009496.1.457 Q6UWI2 PARM1_HUMAN 71.613 0.993355 0.970968 PARM1 - Prostate androgen-regulated mucin-like protein 1 precursor - Homo sapiens (Human) - PARM1 gene May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. Indicus|evm.model.CM009496.1.459 Q96PM5 ZN363_HUMAN 90.805 0.992366 1.00383 RCHY1 - RING finger and CHY zinc finger domain-containing protein 1 - Homo sapiens (Human) - RCHY1 gene Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. Indicus|evm.model.CM009496.1.460 Q8TBB0 THAP6_HUMAN 89.640 0.991031 1.0045 THAP6 - THAP domain-containing protein 6 - Homo sapiens (Human) - THAP6 gene microtubule cytoskeleton Indicus|evm.model.CM009496.1.461 O02772 FABPH_PIG 75.591 0.976744 0.969925 FABP3 - Fatty acid-binding protein, heart - Sus scrofa (Pig) - FABP3 gene FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Indicus|evm.model.CM009496.1.462 Q5R754 CDKL2_PONAB 89.263 0.829825 1.15619 CDKL2 - Cyclin-dependent kinase-like 2 - Pongo abelii (Sumatran orangutan) - CDKL2 gene Indicus|evm.model.CM009496.1.463 Q5R9L3 G3BP2_PONAB 98.548 0.995859 1.00207 G3BP2 - Ras GTPase-activating protein-binding protein 2 - Pongo abelii (Sumatran orangutan) - G3BP2 gene Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Indicus|evm.model.CM009496.1.465 P41541 USO1_BOVIN 99.896 0.997921 1.00104 USO1 - General vesicular transport factor p115 - Bos taurus (Bovine) - USO1 gene General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. Indicus|evm.model.CM009496.1.466 O14830 PPE2_HUMAN 83.673 0.991892 0.982736 PPEF2 - Serine/threonine-protein phosphatase with EF-hands 2 - Homo sapiens (Human) - PPEF2 gene May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission. Indicus|evm.model.CM009496.1.467 Q58DT1 RL7_BOVIN 67.742 0.989418 0.762097 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Indicus|evm.model.CM009496.1.468 Q5KTC7 NAAA_RAT 79.758 0.921788 0.98895 Naaa - N-acylethanolamine-hydrolyzing acid amidase precursor - Rattus norvegicus (Rat) - Naaa gene Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine. Indicus|evm.model.CM009496.1.469 A5D7C2 SDA1_BOVIN 100.000 0.997097 1.00145 SDAD1 - Protein SDA1 homolog - Bos taurus (Bovine) - SDAD1 gene Required for 60S pre-ribosomal subunits export to the cytoplasm. Indicus|evm.model.CM009496.1.470 A9QWP9 CXCL9_BOVIN 100.000 0.984127 1.008 CXCL9 - C-X-C motif chemokine 9 precursor - Bos taurus (Bovine) - CXCL9 gene Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3 (By similarity). Indicus|evm.model.CM009496.1.471 Q2KIQ8 CXL10_BOVIN 99.020 0.980583 1.0098 CXCL10 - C-X-C motif chemokine 10 precursor - Bos taurus (Bovine) - CXCL10 gene Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity). Indicus|evm.model.CM009496.1.472 Q13508 NAR3_HUMAN 70.455 0.982097 1.00514 ART3 - Ecto-ADP-ribosyltransferase 3 precursor - Homo sapiens (Human) - ART3 gene extracellular exosome, extracellular region, intrinsic component of plasma membrane, plasma membrane, NAD+ ADP-ribosyltransferase activity, peptidyl-arginine ADP-ribosylation, protein ADP-ribosylation Indicus|evm.model.CM009496.1.473 Q7Z3B4 NUP54_HUMAN 87.771 0.995816 0.942801 NUP54 - Nucleoporin p54 - Homo sapiens (Human) - NUP54 gene Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Indicus|evm.model.CM009496.1.474 Q14108 SCRB2_HUMAN 88.075 0.995825 1.00209 SCARB2 - Lysosome membrane protein 2 - Homo sapiens (Human) - SCARB2 gene Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. Indicus|evm.model.CM009496.1.475 Q6ZV65 FA47E_HUMAN 62.919 0.995134 1.0458 FAM47E - Protein FAM47E - Homo sapiens (Human) - FAM47E gene Promotes histone methylation by localizing the arginine methyltransferase PRMT5 to chromatin. Indicus|evm.model.CM009496.1.476 O95210 STBD1_HUMAN 65.928 0.99403 0.935754 STBD1 - Starch-binding domain-containing protein 1 - Homo sapiens (Human) - STBD1 gene Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. Indicus|evm.model.CM009496.1.477 Q5M9N0 CD158_HUMAN 89.668 0.998179 0.986523 CCDC158 - Coiled-coil domain-containing protein 158 - Homo sapiens (Human) - CCDC158 gene Indicus|evm.model.CM009496.1.478 Q8TF72 SHRM3_HUMAN 72.805 0.964659 1.00651 SHROOM3 - Protein Shroom3 - Homo sapiens (Human) - SHROOM3 gene Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). Indicus|evm.model.CM009496.1.479 Q6NRK3 SWAHB_XENLA 76.471 0.0424165 0.95695 sowahb - Ankyrin repeat domain-containing protein SOWAHB - Xenopus laevis (African clawed frog) - sowahb gene Indicus|evm.model.CM009496.1.480 A2VE99 SEP11_BOVIN 100.000 0.979215 1.01882 SEPTIN11 - Septin-11 - Bos taurus (Bovine) - SEPTIN11 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). Indicus|evm.model.CM009496.1.481 Q14094 CCNI_HUMAN 94.960 0.994709 1.00265 CCNI - Cyclin-I - Homo sapiens (Human) - CCNI gene cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus, cyclin-dependent protein serine/threonine kinase regulator activity, mitotic cell cycle phase transition, regulation of cyclin-dependent protein serine/threonine kinase activity, spermatogenesis Indicus|evm.model.CM009496.1.482 Q16589 CCNG2_HUMAN 93.605 0.788506 1.26453 CCNG2 - Cyclin-G2 - Homo sapiens (Human) - CCNG2 gene May play a role in growth regulation and in negative regulation of cell cycle progression. Indicus|evm.model.CM009496.1.483 O43927 CXL13_HUMAN 51.402 0.963636 1.00917 CXCL13 - C-X-C motif chemokine 13 precursor - Homo sapiens (Human) - CXCL13 gene Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5. Indicus|evm.model.CM009496.1.484 Q96LI5 CNO6L_HUMAN 100.000 0.994987 0.718919 CNOT6L - CCR4-NOT transcription complex subunit 6-like - Homo sapiens (Human) - CNOT6L gene Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. Indicus|evm.model.CM009496.1.485 A6QPQ5 RM01_BOVIN 99.692 0.993865 1.00308 MRPL1 - 39S ribosomal protein L1, mitochondrial precursor - Bos taurus (Bovine) - MRPL1 gene cytosolic large ribosomal subunit, mitochondrial inner membrane, RNA binding, maturation of LSU-rRNA Indicus|evm.model.CM009496.1.486 Q86XX4 FRAS1_HUMAN 94.935 0.219178 0.965319 FRAS1 - Extracellular matrix organizing protein FRAS1 precursor - Homo sapiens (Human) - FRAS1 gene Involved in extracellular matrix organization (By similarity). Required for the regulation of epidermal-basement membrane adhesion responsible for proper organogenesis during embryonic development (By similarity). Involved in brain organization and function (By similarity). Indicus|evm.model.CM009496.1.487 Q3SWX7 ANXA3_BOVIN 99.381 0.993827 1.0031 ANXA3 - Annexin A3 - Bos taurus (Bovine) - ANXA3 gene Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate (By similarity). Indicus|evm.model.CM009496.1.488 Q9NSY1 BMP2K_HUMAN 80.343 0.998155 0.933678 BMP2K - BMP-2-inducible protein kinase - Homo sapiens (Human) - BMP2K gene May be involved in osteoblast differentiation. Indicus|evm.model.CM009496.1.489 Q6TCH7 PAQR3_HUMAN 99.035 0.99359 1.00322 PAQR3 - Progestin and adipoQ receptor family member 3 - Homo sapiens (Human) - PAQR3 gene Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi. Indicus|evm.model.CM009496.1.490 Q9BSU3 NAA11_HUMAN 90.868 0.947826 1.00437 NAA11 - N-alpha-acetyltransferase 11 - Homo sapiens (Human) - NAA11 gene Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex. Indicus|evm.model.CM009496.1.491 Q63060 GLPK_RAT 85.221 0.871022 1.13931 Gk - Glycerol kinase - Rattus norvegicus (Rat) - Gk gene Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. Indicus|evm.model.CM009496.1.492 P63170 DYL1_RAT 100.000 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Indicus|evm.model.CM009496.1.493 P58335 ANTR2_HUMAN 73.950 0.997462 0.805726 ANTXR2 - Anthrax toxin receptor 2 precursor - Homo sapiens (Human) - ANTXR2 gene Necessary for cellular interactions with laminin and the extracellular matrix. Indicus|evm.model.CM009496.1.494 Q8BZ97 PRDM8_MOUSE 92.903 0.284658 0.787482 Prdm8 - PR domain zinc finger protein 8 - Mus musculus (Mouse) - Prdm8 gene Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (PubMed:19646955). Histone methyltransferase activity has not been confirmed in other species. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (PubMed:19646955). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (PubMed:22284184). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (PubMed:26023183). Indicus|evm.model.CM009496.1.496 A0MTF4 FGF5_BOVIN 99.630 0.99262 1.0037 FGF5 - Fibroblast growth factor 5 precursor - Bos taurus (Bovine) - FGF5 gene Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity). Indicus|evm.model.CM009496.1.497 Q2YDG2 CF299_BOVIN 100.000 0.972973 0.480519 CFAP299 - Cilia- and flagella-associated protein 299 - Bos taurus (Bovine) - CFAP299 gene May be involved in spermatogenesis. Indicus|evm.model.CM009496.1.498 Q2YDG2 CF299_BOVIN 99.180 0.98374 0.532468 CFAP299 - Cilia- and flagella-associated protein 299 - Bos taurus (Bovine) - CFAP299 gene May be involved in spermatogenesis. Indicus|evm.model.CM009496.1.499 P22444 BMP3_BOVIN 100.000 0.995798 1.00211 BMP3 - Bone morphogenetic protein 3 precursor - Bos taurus (Bovine) - BMP3 gene Induces cartilage and bone formation. Indicus|evm.model.CM009496.1.500 Q13237 KGP2_HUMAN 98.358 0.9728 0.82021 PRKG2 - cGMP-dependent protein kinase 2 - Homo sapiens (Human) - PRKG2 gene Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). Indicus|evm.model.CM009496.1.501 Q13237 KGP2_HUMAN 92.810 0.64135 0.311024 PRKG2 - cGMP-dependent protein kinase 2 - Homo sapiens (Human) - PRKG2 gene Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). Indicus|evm.model.CM009496.1.502 A4IFE4 RGF1B_BOVIN 100.000 0.94012 1.06144 RASGEF1B - Ras-GEF domain-containing family member 1B - Bos taurus (Bovine) - RASGEF1B gene Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro). Indicus|evm.model.CM009496.1.505 Q14103 HNRPD_HUMAN 98.873 0.994382 1.00282 HNRNPD - Heterogeneous nuclear ribonucleoprotein D0 - Homo sapiens (Human) - HNRNPD gene Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. Indicus|evm.model.CM009496.1.506 Q9Z130 HNRDL_MOUSE 99.668 0.712589 1.39867 Hnrnpdl - Heterogeneous nuclear ribonucleoprotein D-like - Mus musculus (Mouse) - Hnrnpdl gene Acts as a transcriptional regulator. Promotes transcription repression (By similarity). Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences (By similarity). Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs (By similarity). Binds both to nuclear and cytoplasmic poly(A) mRNAs (By similarity). Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers (By similarity). Binds to the 5'-ACUAGC-3' RNA consensus sequence (By similarity). Indicus|evm.model.CM009496.1.507 Q0VD27 ENOPH_BOVIN 100.000 0.992366 1.00383 ENOPH1 - Enolase-phosphatase E1 - Bos taurus (Bovine) - ENOPH1 gene Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Indicus|evm.model.CM009496.1.508 A5D7C9 T150C_BOVIN 100.000 0.992 1.00402 TMEM150C - Transmembrane protein 150C - Bos taurus (Bovine) - TMEM150C gene Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception. Indicus|evm.model.CM009496.1.509 Q2KIA4 SCD5_BOVIN 100.000 0.994048 1.00299 SCD5 - Stearoyl-CoA desaturase 5 - Bos taurus (Bovine) - SCD5 gene Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways. Indicus|evm.model.CM009496.1.510 Q5R4F4 SC31A_PONAB 93.860 0.191238 1.07324 SEC31A - Protein transport protein Sec31A - Pongo abelii (Sumatran orangutan) - SEC31A gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (By similarity). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). Indicus|evm.model.CM009496.1.512 Q9H5L6 THAP9_HUMAN 85.651 0.996667 0.996678 THAP9 - DNA transposase THAP9 - Homo sapiens (Human) - THAP9 gene Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition. Indicus|evm.model.CM009496.1.513 Q5RBN8 LIN54_PONAB 98.659 0.695594 1.41856 LIN54 - Protein lin-54 homolog - Pongo abelii (Sumatran orangutan) - LIN54 gene Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA. Indicus|evm.model.CM009496.1.514 Q3SZA0 CSN4_BOVIN 100.000 0.995086 1.00246 COPS4 - COP9 signalosome complex subunit 4 - Bos taurus (Bovine) - COPS4 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Indicus|evm.model.CM009496.1.515 Q3ZCB2 PLAC8_BOVIN 100.000 0.982906 1.00862 PLAC8 - Placenta-specific gene 8 protein - Bos taurus (Bovine) - PLAC8 gene positive regulation of transcription by RNA polymerase II Indicus|evm.model.CM009496.1.516 Q3ZCB2 PLAC8_BOVIN 62.136 0.918182 0.948276 PLAC8 - Placenta-specific gene 8 protein - Bos taurus (Bovine) - PLAC8 gene positive regulation of transcription by RNA polymerase II Indicus|evm.model.CM009496.1.517 Q2KIQ4 COQ2_BOVIN 98.922 0.994624 1.0027 COQ2 - 4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor - Bos taurus (Bovine) - COQ2 gene Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. Indicus|evm.model.CM009496.1.518 Q9MYY0 HPSE_BOVIN 98.810 0.916211 1.00734 HPSE - Heparanase precursor - Bos taurus (Bovine) - HPSE gene Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. Essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans. Acts as procoagulant by enhancing the generation of activated factor X/F10 in the presence of tissue factor/TF and activated factor VII/F7. Independent of its enzymatic activity, increases cell adhesion to the extracellular matrix (ECM). Enhances AKT1/PKB phosphorylation, possibly via interaction with a lipid raft-resident receptor. Plays a role in the regulation of osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis (By similarity). Indicus|evm.model.CM009496.1.519 Q8TDG4 HELQ_HUMAN 79.764 0.998035 0.924614 HELQ - Helicase POLQ-like - Homo sapiens (Human) - HELQ gene Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase (PubMed:11751861). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904). Indicus|evm.model.CM009496.1.520 P82917 RT18C_BOVIN 100.000 0.986111 1.00699 MRPS18C - 28S ribosomal protein S18c, mitochondrial precursor - Bos taurus (Bovine) - MRPS18C gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit rRNA binding, structural constituent of ribosome Indicus|evm.model.CM009496.1.521 Q5E9P1 ABRX1_BOVIN 99.475 0.796646 1.16341 ABRAXAS1 - BRCA1-A complex subunit Abraxas 1 - Bos taurus (Bovine) - ABRAXAS1 gene Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Indicus|evm.model.CM009496.1.522 Q53EU6 GPAT3_HUMAN 91.917 0.984055 1.01152 GPAT3 - Glycerol-3-phosphate acyltransferase 3 - Homo sapiens (Human) - GPAT3 gene Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427). Indicus|evm.model.CM009496.1.523 Q5RFL9 NONO_PONAB 93.827 0.98773 0.346072 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009496.1.524 P78426 NKX61_HUMAN 94.022 0.99455 1 NKX6-1 - Homeobox protein Nkx-6.1 - Homo sapiens (Human) - NKX6-1 gene Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). Indicus|evm.model.CM009496.1.525 Q92903 CDS1_HUMAN 96.328 0.99568 1.00434 CDS1 - Phosphatidate cytidylyltransferase 1 - Homo sapiens (Human) - CDS1 gene Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:9407135, PubMed:25375833). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (PubMed:25375833). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). Positively regulates the differentiation and development of adipocytes (By similarity). Indicus|evm.model.CM009496.1.526 Q8IZQ1 WDFY3_HUMAN 97.023 0.999429 0.992626 WDFY3 - WD repeat and FYVE domain-containing protein 3 - Homo sapiens (Human) - WDFY3 gene Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). Indicus|evm.model.CM009496.1.528 Q8N264 RHG24_HUMAN 94.526 0.989418 1.0107 ARHGAP24 - Rho GTPase-activating protein 24 - Homo sapiens (Human) - ARHGAP24 gene Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. Indicus|evm.model.CM009496.1.529 P53779 MK10_HUMAN 97.608 0.985816 0.911638 MAPK10 - Mitogen-activated protein kinase 10 - Homo sapiens (Human) - MAPK10 gene Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). Indicus|evm.model.CM009496.1.530 Q66X52 LTOR5_PIG 85.714 0.978261 1.01099 LAMTOR5 - Ragulator complex protein LAMTOR5 - Sus scrofa (Pig) - LAMTOR5 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Indicus|evm.model.CM009496.1.531 Q28CQ4 UBC9_XENTR 99.301 0.986111 0.911392 ube2i - SUMO-conjugating enzyme UBC9 - Xenopus tropicalis (Western clawed frog) - ube2i gene Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation. Indicus|evm.model.CM009496.1.532 Q12923 PTN13_HUMAN 92.889 0.476807 0.746076 PTPN13 - Tyrosine-protein phosphatase non-receptor type 13 - Homo sapiens (Human) - PTPN13 gene Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). Indicus|evm.model.CM009496.1.533 A6QP84 SOAT_BOVIN 100.000 0.297619 1.11406 SLC10A6 - Solute carrier family 10 member 6 - Bos taurus (Bovine) - SLC10A6 gene Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner. Indicus|evm.model.CM009496.1.534 Q96KX1 CD036_HUMAN 75.789 0.979167 0.820513 C4orf36 - Uncharacterized protein C4orf36 - Homo sapiens (Human) - C4orf36 gene Indicus|evm.model.CM009496.1.535 P51825 AFF1_HUMAN 80.146 0.998363 1.00992 AFF1 - AF4/FMR2 family member 1 - Homo sapiens (Human) - AFF1 gene super elongation complex, transcription elongation factor complex, regulation of gene expression Indicus|evm.model.CM009496.1.536 Q9P2G9 KLHL8_HUMAN 95.806 0.996764 0.996774 KLHL8 - Kelch-like protein 8 - Homo sapiens (Human) - KLHL8 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN. Indicus|evm.model.CM009496.1.537 P84246 H33_RABIT 97.059 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009496.1.538 Q7Z5P4 DHB13_HUMAN 87.368 0.943522 1.00333 HSD17B13 - 17-beta-hydroxysteroid dehydrogenase 13 precursor - Homo sapiens (Human) - HSD17B13 gene cytosol, lipid droplet, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, steroid dehydrogenase activity, lipid droplet organization, positive regulation of lipid biosynthetic process Indicus|evm.model.CM009496.1.539 Q8NBQ5 DHB11_HUMAN 75.088 0.881295 0.926667 HSD17B11 - Estradiol 17-beta-dehydrogenase 11 precursor - Homo sapiens (Human) - HSD17B11 gene Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. Indicus|evm.model.CM009496.1.540 Q5EAE5 JOS1_BOVIN 96.748 0.968254 0.623762 JOSD1 - Josephin-1 - Bos taurus (Bovine) - JOSD1 gene Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity). Indicus|evm.model.CM009496.1.541 Q8BVU5 NUDT9_MOUSE 86.550 0.974286 1 Nudt9 - ADP-ribose pyrophosphatase, mitochondrial precursor - Mus musculus (Mouse) - Nudt9 gene Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. Indicus|evm.model.CM009496.1.542 Q14515 SPRL1_HUMAN 70.721 0.85469 1.14006 SPARCL1 - SPARC-like protein 1 precursor - Homo sapiens (Human) - SPARCL1 gene endoplasmic reticulum lumen, extracellular region, extracellular space, calcium ion binding, collagen binding, extracellular matrix binding, anatomical structure development, cellular protein metabolic process, post-translational protein modification Indicus|evm.model.CM009496.1.543 Q9NZW4 DSPP_HUMAN 58.553 0.542039 0.429669 DSPP - Dentin sialophosphoprotein precursor - Homo sapiens (Human) - DSPP gene DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. Indicus|evm.model.CM009496.1.544 Q95120 DMP1_BOVIN 99.216 0.992203 1.00588 DMP1 - Dentin matrix acidic phosphoprotein 1 precursor - Bos taurus (Bovine) - DMP1 gene May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity). Indicus|evm.model.CM009496.1.545 Q28949 MA2B2_PIG 57.606 0.926471 0.956784 MAN2B2 - Epididymis-specific alpha-mannosidase precursor - Sus scrofa (Pig) - MAN2B2 gene Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida. Indicus|evm.model.CM009496.1.546 Q28949 MA2B2_PIG 68.657 0.946356 0.992965 MAN2B2 - Epididymis-specific alpha-mannosidase precursor - Sus scrofa (Pig) - MAN2B2 gene Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida. Indicus|evm.model.CM009496.1.547 Q9Y2T4 2ABG_HUMAN 99.764 0.937916 1.00895 PPP2R2C - Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform - Homo sapiens (Human) - PPP2R2C gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Indicus|evm.model.CM009496.1.548 O76024 WFS1_HUMAN 86.854 0.987751 1.00899 WFS1 - Wolframin - Homo sapiens (Human) - WFS1 gene Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (PubMed:16989814). Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (PubMed:23035048). Indicus|evm.model.CM009496.1.550 Q9P0W2 HM20B_HUMAN 59.406 0.264151 1.17035 HMG20B - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related - Homo sapiens (Human) - HMG20B gene Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters. Indicus|evm.model.CM009496.1.552 A6QR54 JKIP1_BOVIN 99.669 0.726835 1.32748 JAKMIP1 - Janus kinase and microtubule-interacting protein 1 - Bos taurus (Bovine) - JAKMIP1 gene Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements (By similarity). Indicus|evm.model.CM009496.1.553 Q6ZRC1 CD050_HUMAN 55.957 0.149697 5.37319 C4orf50 - Uncharacterized protein C4orf50 - Homo sapiens (Human) - C4orf50 gene Indicus|evm.model.CM009496.1.554 Q14194 DPYL1_HUMAN 97.552 0.99651 1.00175 CRMP1 - Dihydropyrimidinase-related protein 1 - Homo sapiens (Human) - CRMP1 gene Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). Indicus|evm.model.CM009496.1.555 P57679 EVC_HUMAN 79.936 0.960946 0.980847 EVC - Ellis-van Creveld syndrome protein - Homo sapiens (Human) - EVC gene Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. Indicus|evm.model.CM009496.1.556 Q8MI28 LBN_BOVIN 97.865 0.899563 0.757651 EVC2 - Limbin - Bos taurus (Bovine) - EVC2 gene Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis. Indicus|evm.model.CM009496.1.557 Q9JJX8 ST32B_MOUSE 94.627 0.962536 0.838164 Stk32b - Serine/threonine-protein kinase 32B - Mus musculus (Mouse) - Stk32b gene protein serine/threonine kinase activity, intracellular signal transduction, peptidyl-serine phosphorylation Indicus|evm.model.CM009496.1.558 Q9NRR1 CYTL1_HUMAN 84.348 0.826087 1.01471 CYTL1 - Cytokine-like protein 1 precursor - Homo sapiens (Human) - CYTL1 gene extracellular space, signaling receptor binding, signal transduction Indicus|evm.model.CM009496.1.559 O02786 MSX1_BOVIN 97.360 0.993421 1.0033 MSX1 - Homeobox protein MSX-1 - Bos taurus (Bovine) - MSX1 gene Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). Indicus|evm.model.CM009496.1.561 Q9P2W9 STX18_HUMAN 93.433 0.994048 1.00299 STX18 - Syntaxin-18 - Homo sapiens (Human) - STX18 gene Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Indicus|evm.model.CM009496.1.562 O15254 ACOX3_HUMAN 78.199 0.858696 1.05143 ACOX3 - Peroxisomal acyl-coenzyme A oxidase 3 - Homo sapiens (Human) - ACOX3 gene Oxidizes the CoA-esters of 2-methyl-branched fatty acids. Indicus|evm.model.CM009496.1.563 Q8IYL2 TRM44_HUMAN 71.242 0.993447 1.00793 TRMT44 - Probable tRNA (uracil-O(2)-)-methyltransferase - Homo sapiens (Human) - TRMT44 gene Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. Indicus|evm.model.CM009496.1.565 Q66K79 CBPZ_HUMAN 86.164 0.970543 0.989264 CPZ - Carboxypeptidase Z precursor - Homo sapiens (Human) - CPZ gene Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. Indicus|evm.model.CM009496.1.568 O70218 HMX1_MOUSE 97.222 0.189333 1.12952 Hmx1 - Homeobox protein HMX1 - Mus musculus (Mouse) - Hmx1 gene DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear. Indicus|evm.model.CM009496.1.569 P18825 ADA2C_HUMAN 98.438 0.329016 0.835498 ADRA2C - Alpha-2C adrenergic receptor - Homo sapiens (Human) - ADRA2C gene Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Indicus|evm.model.CM009496.1.572 Q99068 AMRP_RAT 74.242 0.906336 1.00833 Lrpap1 - Alpha-2-macroglobulin receptor-associated protein precursor - Rattus norvegicus (Rat) - Lrpap1 gene Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. Indicus|evm.model.CM009496.1.573 Q18PE1 DOK7_HUMAN 89.963 0.560924 0.944444 DOK7 - Protein Dok-7 - Homo sapiens (Human) - DOK7 gene Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. Indicus|evm.model.CM009496.1.574 Q6QNF4 HGFA_CANLF 88.000 0.484305 1.02294 HGFAC - Hepatocyte growth factor activator precursor - Canis lupus familiaris (Dog) - HGFAC gene Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. Indicus|evm.model.CM009496.1.575 P02683 NSG1_RAT 98.810 0.0651491 6.88649 Nsg1 - Neuronal vesicle trafficking-associated protein 1 - Rattus norvegicus (Rat) - Nsg1 gene Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway (PubMed:18299352, PubMed:15911354). Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (PubMed:15911354). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (PubMed:18299352). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity). Indicus|evm.model.CM009496.1.576 Q6ZSB9 ZBT49_HUMAN 80.130 0.997389 1.00131 ZBTB49 - Zinc finger and BTB domain-containing protein 49 - Homo sapiens (Human) - ZBTB49 gene Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. Indicus|evm.model.CM009496.1.578 Q9NX58 LYAR_HUMAN 75.835 0.994778 1.01055 LYAR - Cell growth-regulating nucleolar protein - Homo sapiens (Human) - LYAR gene Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity). Indicus|evm.model.CM009496.1.579 Q3T0S0 TM128_BOVIN 99.394 0.987952 1.00606 TMEM128 - Transmembrane protein 128 - Bos taurus (Bovine) - TMEM128 gene Indicus|evm.model.CM009496.1.580 Q7RTM1 OTOP1_HUMAN 84.561 0.921824 1.00327 OTOP1 - Proton channel OTOP1 - Homo sapiens (Human) - OTOP1 gene Proton-selective channel that specifically transports protons into cells (PubMed:29371428). Proton channel activity is only weakly-sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PubMed:29371428). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity). Regulates purinergic control of intracellular calcium in vestibular supporting cells (By similarity). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity). Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction (By similarity). Indicus|evm.model.CM009496.1.581 P21918 DRD5_HUMAN 83.925 0.995781 0.993711 DRD5 - D(1B) dopamine receptor - Homo sapiens (Human) - DRD5 gene Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Indicus|evm.model.CM009496.1.582 Q9NRM0 GTR9_HUMAN 82.407 0.829457 0.238889 SLC2A9 - Solute carrier family 2, facilitated glucose transporter member 9 - Homo sapiens (Human) - SLC2A9 gene Urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:28083649). Does not transport glucose, fructose or galactose (PubMed:28083649). Indicus|evm.model.CM009496.1.583 Q8BIL2 MSD1_MOUSE 89.575 0.553648 1.67626 Msantd1 - Myb/SANT-like DNA-binding domain-containing protein 1 - Mus musculus (Mouse) - Msantd1 gene nuclear body, positive regulation of transcription, DNA-templated Indicus|evm.model.CM009496.1.584 P42858 HD_HUMAN 89.001 0.980818 0.995544 HTT - Huntingtin - Homo sapiens (Human) - HTT gene May play a role in microtubule-mediated transport or vesicle function. Indicus|evm.model.CM009496.1.585 P32298 GRK4_HUMAN 77.178 0.98791 1.00173 GRK4 - G protein-coupled receptor kinase 4 - Homo sapiens (Human) - GRK4 gene Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. Indicus|evm.model.CM009496.1.586 P78316 NOP14_HUMAN 77.252 0.986207 1.01517 NOP14 - Nucleolar protein 14 - Homo sapiens (Human) - NOP14 gene Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). Indicus|evm.model.CM009496.1.587 Q0P5M9 MFS10_BOVIN 100.000 0.995624 1.00219 MFSD10 - Major facilitator superfamily domain-containing protein 10 - Bos taurus (Bovine) - MFSD10 gene Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump (By similarity). Indicus|evm.model.CM009496.1.588 P35611 ADDA_HUMAN 87.404 0.997403 1.04478 ADD1 - Alpha-adducin - Homo sapiens (Human) - ADD1 gene Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Indicus|evm.model.CM009496.1.589 P78314 3BP2_HUMAN 83.392 0.928808 1.07665 SH3BP2 - SH3 domain-binding protein 2 - Homo sapiens (Human) - SH3BP2 gene Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. Indicus|evm.model.CM009496.1.590 Q8NFZ5 TNIP2_HUMAN 76.855 0.770115 1.01399 TNIP2 - TNFAIP3-interacting protein 2 - Homo sapiens (Human) - TNIP2 gene Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. Indicus|evm.model.CM009496.1.591 P78312 F193A_HUMAN 79.274 0.921462 1.0166 FAM193A - Protein FAM193A - Homo sapiens (Human) - FAM193A gene Indicus|evm.model.CM009496.1.592 Q9QZS2 RNF4_MOUSE 89.840 0.973262 0.963918 Rnf4 - E3 ubiquitin-protein ligase RNF4 - Mus musculus (Mouse) - Rnf4 gene E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Indicus|evm.model.CM009496.1.593 D6REC4 CFA99_HUMAN 72.360 0.525368 1.33115 CFAP99 - Cilia- and flagella-associated protein 99 - Homo sapiens (Human) - CFAP99 gene Indicus|evm.model.CM009496.1.594 A0JMD2 LST2_DANRE 80.220 0.214709 0.869969 zfyve28 - Lateral signaling target protein 2 homolog - Danio rerio (Zebrafish) - zfyve28 gene Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity). Indicus|evm.model.CM009496.1.595 Q60948 MAD4_MOUSE 90.385 0.707763 1.04785 Mxd4 - Max dimerization protein 4 - Mus musculus (Mouse) - Mxd4 gene Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. Indicus|evm.model.CM009496.1.596 Q68CZ6 HAUS3_HUMAN 86.401 0.996678 0.998342 HAUS3 - HAUS augmin-like complex subunit 3 - Homo sapiens (Human) - HAUS3 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Indicus|evm.model.CM009496.1.598 Q7TQ07 DPOLN_MOUSE 76.812 0.245238 0.972222 Poln - DNA polymerase nu - Mus musculus (Mouse) - Poln gene DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template. Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity. Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence. May play a role in TLS during interstrand cross-link (ICL) repair. May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links. Indicus|evm.model.CM009496.1.600 D3ZVU9 NAT8L_RAT 87.435 0.822511 0.772575 Nat8l - N-acetylaspartate synthetase - Rattus norvegicus (Rat) - Nat8l gene Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake (By similarity). Indicus|evm.model.CM009496.1.601 Q5H8A4 PIGG_HUMAN 76.429 0.994797 0.97762 PIGG - GPI ethanolamine phosphate transferase 2 - Homo sapiens (Human) - PIGG gene Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. Indicus|evm.model.CM009496.1.603 Q4A1L4 BECN1_BOVIN 95.789 0.854545 0.245536 BECN1 - Beclin-1 - Bos taurus (Bovine) - BECN1 gene Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity). Indicus|evm.model.CM009496.1.604 P23439 PDE6B_BOVIN 88.628 0.997491 0.934349 PDE6B - Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor - Bos taurus (Bovine) - PDE6B gene Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal (By similarity). Indicus|evm.model.CM009496.1.605 Q00361 ATP5I_BOVIN 100.000 0.96 0.704225 ATP5ME - ATP synthase subunit e, mitochondrial - Bos taurus (Bovine) - ATP5ME gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Indicus|evm.model.CM009496.1.607 Q8CE47 S49A3_MOUSE 74.545 0.910788 0.934109 Slc49a3 - Solute carrier family 49 member A3 - Mus musculus (Mouse) - Slc49a3 gene Indicus|evm.model.CM009496.1.608 Q2KJ29 PCGF3_BOVIN 76.033 0.850202 1.02066 PCGF3 - Polycomb group RING finger protein 3 - Bos taurus (Bovine) - PCGF3 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). Indicus|evm.model.CM009496.1.612 O14976 GAK_HUMAN 78.797 0.962085 0.965675 GAK - Cyclin-G-associated kinase - Homo sapiens (Human) - GAK gene Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. Indicus|evm.model.CM009496.1.613 Q32PG7 TM175_BOVIN 91.260 0.995699 0.970772 TMEM175 - Endosomal/lysosomal potassium channel TMEM175 - Bos taurus (Bovine) - TMEM175 gene Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel. Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors. The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation. The lysoK(GF) complex is required to protect neurons against stress-induced damage. Indicus|evm.model.CM009496.1.614 Q6P5E8 DGKQ_MOUSE 81.258 0.954208 0.865096 Dgkq - Diacylglycerol kinase theta - Mus musculus (Mouse) - Dgkq gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:26748701). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). Indicus|evm.model.CM009496.1.615 P52824 DGKQ_HUMAN 85.714 0.454545 0.12845 DGKQ - Diacylglycerol kinase theta - Homo sapiens (Human) - DGKQ gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9099683, PubMed:11309392, PubMed:22627129). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). Indicus|evm.model.CM009496.1.616 Q01634 IDUA_CANLF 88.462 0.351724 0.221374 IDUA - Alpha-L-iduronidase precursor - Canis lupus familiaris (Dog) - IDUA gene hydrolase activity, hydrolyzing O-glycosyl compounds, L-iduronidase activity, dermatan sulfate catabolic process Indicus|evm.model.CM009496.1.617 Q9H2B4 S26A1_HUMAN 79.037 0.997171 1.00856 SLC26A1 - Sulfate anion transporter 1 - Homo sapiens (Human) - SLC26A1 gene Mediates sulfate transport with high affinity (PubMed:12713736). Mediates oxalate transport (PubMed:12713736). Mediates bicarbonate transport (By similarity). Does not accept succinate as cosubstrate (By similarity). Indicus|evm.model.CM009496.1.618 P35475 IDUA_HUMAN 82.472 0.898671 0.921899 IDUA - Alpha-L-iduronidase precursor - Homo sapiens (Human) - IDUA gene extracellular exosome, lysosomal lumen, hydrolase activity, hydrolyzing O-glycosyl compounds, L-iduronidase activity, chondroitin sulfate catabolic process, dermatan sulfate catabolic process, disaccharide metabolic process, glycosaminoglycan catabolic process, heparin catabolic process Indicus|evm.model.CM009496.1.619 Q0IIL7 CPLX1_BOVIN 100.000 0.252174 1.71642 CPLX1 - Complexin-1 - Bos taurus (Bovine) - CPLX1 gene Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity). Indicus|evm.model.CM009496.1.620 Q8N441 FGRL1_HUMAN 90.336 0.995772 0.938492 FGFRL1 - Fibroblast growth factor receptor-like 1 precursor - Homo sapiens (Human) - FGFRL1 gene Has a negative effect on cell proliferation. Indicus|evm.model.CM009496.1.622 P27869 TMD11_CANLF 86.842 0.190898 3.67907 TMED11 - Transmembrane emp24 domain-containing protein 11 precursor - Canis lupus familiaris (Dog) - TMED11 gene Part of a complex whose function is to bind Ca(2+) to the ER membrane and thereby regulate the retention of ER resident proteins. Indicus|evm.model.CM009496.1.623 O88712 CTBP1_MOUSE 98.298 0.288889 1.83673 Ctbp1 - C-terminal-binding protein 1 - Mus musculus (Mouse) - Ctbp1 gene Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Indicus|evm.model.CM009496.1.626 Q3MHJ2 MAEA_BOVIN 100.000 0.985577 0.958525 MAEA - E3 ubiquitin-protein transferase MAEA - Bos taurus (Bovine) - MAEA gene Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity). Indicus|evm.model.CM009496.1.627 F1MX48 UVSSA_BOVIN 98.540 0.975434 1.01022 UVSSA - UV-stimulated scaffold protein A - Bos taurus (Bovine) - UVSSA gene Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage (By similarity). Indicus|evm.model.CM009496.1.634 P97440 SLBP_MOUSE 86.545 0.992754 1.00364 Slbp - Histone RNA hairpin-binding protein - Mus musculus (Mouse) - Slbp gene RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (By similarity). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs. Indicus|evm.model.CM009496.1.635 Q08DK0 TM129_BOVIN 100.000 0.99449 1.00276 TMEM129 - E3 ubiquitin-protein ligase TM129 - Bos taurus (Bovine) - TMEM129 gene E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation. Indicus|evm.model.CM009496.1.636 Q9JJ11 TACC3_MOUSE 61.538 0.127004 1.28526 Tacc3 - Transforming acidic coiled-coil-containing protein 3 - Mus musculus (Mouse) - Tacc3 gene Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (PubMed:17920017). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). May be involved in the control of cell growth and differentiation. May have a role in embryonic development. Indicus|evm.model.CM009496.1.637 P22607 FGFR3_HUMAN 88.089 0.997406 0.956576 FGFR3 - Fibroblast growth factor receptor 3 precursor - Homo sapiens (Human) - FGFR3 gene Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. Indicus|evm.model.CM009496.1.638 Q0VCA3 LETM1_BOVIN 99.156 0.898734 1.07923 LETM1 - Mitochondrial proton/calcium exchanger protein precursor - Bos taurus (Bovine) - LETM1 gene Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity). Indicus|evm.model.CM009496.1.640 O96028 NSD2_HUMAN 86.846 0.97877 1.00073 NSD2 - Histone-lysine N-methyltransferase NSD2 - Homo sapiens (Human) - NSD2 gene Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). Indicus|evm.model.CM009496.1.641 Q9H3P2 NELFA_HUMAN 96.104 0.86236 0.674242 NELFA - Negative elongation factor A - Homo sapiens (Human) - NELFA gene Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Indicus|evm.model.CM009496.1.643 A0JNN8 CD048_BOVIN 94.545 0.710526 0.783505 Neuropeptide-like protein C4orf48 homolog precursor - Bos taurus (Bovine) Indicus|evm.model.CM009496.1.644 Q3T9X0 GTR9_MOUSE 81.325 0.637066 0.481413 Slc2a9 - Solute carrier family 2, facilitated glucose transporter member 9 - Mus musculus (Mouse) - Slc2a9 gene Urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:19587147, PubMed:25100214). Does not transport glucose, fructose or galactose (By similarity). Indicus|evm.model.CM009496.1.645 Q5RB09 GTR9_PONAB 77.239 0.748571 0.618375 SLC2A9 - Solute carrier family 2, facilitated glucose transporter member 9 - Pongo abelii (Sumatran orangutan) - SLC2A9 gene Urate transporter, which may play a role in the urate reabsorption by proximal tubules (By similarity). Does not transport glucose, fructose or galactose (By similarity). Indicus|evm.model.CM009496.1.646 Q2KJH4 WDR1_BOVIN 98.197 0.996727 1.00825 WDR1 - WD repeat-containing protein 1 - Bos taurus (Bovine) - WDR1 gene Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity). Indicus|evm.model.CM009496.1.647 Q9C0D4 Z518B_HUMAN 74.722 0.998146 1.00466 ZNF518B - Zinc finger protein 518B - Homo sapiens (Human) - ZNF518B gene Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes. Indicus|evm.model.CM009496.1.648 Q7Z7G1 CLNK_HUMAN 70.960 0.958525 1.01402 CLNK - Cytokine-dependent hematopoietic cell linker - Homo sapiens (Human) - CLNK gene An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (By similarity). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (By similarity). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (By similarity). Involved in phosphorylation of LAT (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). Indicus|evm.model.CM009496.1.649 O14792 HS3S1_HUMAN 68.595 0.960212 1.22801 HS3ST1 - Heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor - Homo sapiens (Human) - HS3ST1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Indicus|evm.model.CM009496.1.652 Q3SWY9 RAB28_BOVIN 100.000 0.990991 1.00452 RAB28 - Ras-related protein Rab-28 precursor - Bos taurus (Bovine) - RAB28 gene ciliary basal body, ciliary rootlet, GDP binding, GTP binding Indicus|evm.model.CM009496.1.653 P78367 NKX32_HUMAN 89.189 0.993958 0.993994 NKX3-2 - Homeobox protein Nkx-3.2 - Homo sapiens (Human) - NKX3-2 gene Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). Indicus|evm.model.CM009496.1.654 Q5SQY2 BOD1_MOUSE 72.289 0.0281014 16.8671 Bod1 - Biorientation of chromosomes in cell division protein 1 - Mus musculus (Mouse) - Bod1 gene Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Indicus|evm.model.CM009496.1.656 Q7Z5Q1 CPEB2_HUMAN 96.130 0.796748 1.04414 CPEB2 - Cytoplasmic polyadenylation element-binding protein 2 - Homo sapiens (Human) - CPEB2 gene May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). Indicus|evm.model.CM009496.1.657 Q9BXJ2 C1QT7_HUMAN 97.578 0.986301 1.01038 C1QTNF7 - Complement C1q tumor necrosis factor-related protein 7 precursor - Homo sapiens (Human) - C1QTNF7 gene Indicus|evm.model.CM009496.1.658 Q9P2K1 C2D2A_HUMAN 84.516 0.998748 0.98642 CC2D2A - Coiled-coil and C2 domain-containing protein 2A - Homo sapiens (Human) - CC2D2A gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). Indicus|evm.model.CM009496.1.659 A2VE78 FBXL5_BOVIN 99.699 0.941761 1.01881 FBXL5 - F-box/LRR-repeat protein 5 - Bos taurus (Bovine) - FBXL5 gene Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). Indicus|evm.model.CM009496.1.660 P0CF97 F200B_HUMAN 83.994 0.989378 1.00304 FAM200B - Protein FAM200B - Homo sapiens (Human) - FAM200B gene Indicus|evm.model.CM009496.1.661 Q64277 BST1_MOUSE 76.772 0.916058 0.881029 Bst1 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor - Mus musculus (Mouse) - Bst1 gene Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth. Indicus|evm.model.CM009496.1.662 Q64244 CD38_RAT 49.160 0.83871 0.920792 Cd38 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 - Rattus norvegicus (Rat) - Cd38 gene Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Indicus|evm.model.CM009496.1.663 Q9MZ06 FGFP1_BOVIN 98.291 0.991489 1.00427 FGFBP1 - Fibroblast growth factor-binding protein 1 precursor - Bos taurus (Bovine) - FGFBP1 gene Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity). Indicus|evm.model.CM009496.1.664 P55210 CASP7_HUMAN 75.439 0.321212 0.544554 CASP7 - Caspase-7 precursor - Homo sapiens (Human) - CASP7 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. Indicus|evm.model.CM009496.1.665 O43490 PROM1_HUMAN 54.902 0.941589 0.989595 PROM1 - Prominin-1 precursor - Homo sapiens (Human) - PROM1 gene May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439). Indicus|evm.model.CM009496.1.666 Q4VBD2 TAPT1_MOUSE 93.173 0.676796 1.28369 Tapt1 - Transmembrane anterior posterior transformation protein 1 - Mus musculus (Mouse) - Tapt1 gene Plays a role in primary cilia formation (By similarity). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). Indicus|evm.model.CM009496.1.667 O43679 LDB2_HUMAN 98.660 0.994652 1.00268 LDB2 - LIM domain-binding protein 2 - Homo sapiens (Human) - LDB2 gene Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. Indicus|evm.model.CM009496.1.671 Q3T0Z7 DHPR_BOVIN 100.000 0.832 1.03306 QDPR - Dihydropteridine reductase - Bos taurus (Bovine) - QDPR gene The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. Indicus|evm.model.CM009496.1.672 A0PK11 CLRN2_HUMAN 93.534 0.991416 1.00431 CLRN2 - Clarin-2 - Homo sapiens (Human) - CLRN2 gene Indicus|evm.model.CM009496.1.674 Q28949 MA2B2_PIG 88.889 0.0201381 1.74673 MAN2B2 - Epididymis-specific alpha-mannosidase precursor - Sus scrofa (Pig) - MAN2B2 gene Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida. Indicus|evm.model.CM009496.1.675 Q28949 MA2B2_PIG 72.889 0.79469 0.567839 MAN2B2 - Epididymis-specific alpha-mannosidase precursor - Sus scrofa (Pig) - MAN2B2 gene Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida. Indicus|evm.model.CM009496.1.676 Q28949 MA2B2_PIG 69.211 0.952321 0.801005 MAN2B2 - Epididymis-specific alpha-mannosidase precursor - Sus scrofa (Pig) - MAN2B2 gene Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida. Indicus|evm.model.CM009496.1.677 Q3ZC61 MOFA1_BOVIN 100.000 0.984375 1.00787 MRFAP1 - MORF4 family-associated protein 1 - Bos taurus (Bovine) - MRFAP1 gene Indicus|evm.model.CM009496.1.678 Q9NUP1 BL1S4_HUMAN 81.095 0.930233 0.990783 BLOC1S4 - Biogenesis of lysosome-related organelles complex 1 subunit 4 - Homo sapiens (Human) - BLOC1S4 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. Indicus|evm.model.CM009496.1.679 Q92628 K0232_HUMAN 87.678 0.998577 1.00717 KIAA0232 - Uncharacterized protein KIAA0232 - Homo sapiens (Human) - KIAA0232 gene Indicus|evm.model.CM009496.1.680 A6H7I8 TBC14_BOVIN 100.000 0.99705 0.979769 TBC1D14 - TBC1 domain family member 14 - Bos taurus (Bovine) - TBC1D14 gene Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. Indicus|evm.model.CM009496.1.681 Q95LS7 CCD96_MACFA 82.386 0.839713 0.746429 CCDC96 - Coiled-coil domain-containing protein 96 - Macaca fascicularis (Crab-eating macaque) - CCDC96 gene Indicus|evm.model.CM009496.1.682 Q5RBN9 TAD2B_PONAB 94.627 0.994048 0.8 TADA2B - Transcriptional adapter 2-beta - Pongo abelii (Sumatran orangutan) - TADA2B gene Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. Indicus|evm.model.CM009496.1.683 Q3SZC1 GRPE1_BOVIN 100.000 0.990826 1.00461 GRPEL1 - GrpE protein homolog 1, mitochondrial precursor - Bos taurus (Bovine) - GRPEL1 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). Indicus|evm.model.CM009496.1.686 Q6NUJ1 SAPL1_HUMAN 59.000 0.921933 1.03263 PSAPL1 - Proactivator polypeptide-like 1 precursor - Homo sapiens (Human) - PSAPL1 gene May activate the lysosomal degradation of sphingolipids. Indicus|evm.model.CM009496.1.687 Q96PQ0 SORC2_HUMAN 92.308 0.120253 0.272649 SORCS2 - VPS10 domain-containing receptor SorCS2 precursor - Homo sapiens (Human) - SORCS2 gene The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:22155786, PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814). Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (PubMed:22155786). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (By similarity). Indicus|evm.model.CM009496.1.689 Q96PQ0 SORC2_HUMAN 87.273 0.4 0.11648 SORCS2 - VPS10 domain-containing receptor SorCS2 precursor - Homo sapiens (Human) - SORCS2 gene The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:22155786, PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814). Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (PubMed:22155786). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (By similarity). Indicus|evm.model.CM009496.1.690 Q96PQ0 SORC2_HUMAN 87.758 0.99316 0.630716 SORCS2 - VPS10 domain-containing receptor SorCS2 precursor - Homo sapiens (Human) - SORCS2 gene The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:22155786, PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814). Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (PubMed:22155786). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (By similarity). Indicus|evm.model.CM009496.1.691 Q8N556 AFAP1_HUMAN 89.216 0.60533 1.07945 AFAP1 - Actin filament-associated protein 1 - Homo sapiens (Human) - AFAP1 gene Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. Indicus|evm.model.CM009496.1.693 Q6H8Q1 ABLM2_HUMAN 84.437 0.889381 1.10966 ABLIM2 - Actin-binding LIM protein 2 - Homo sapiens (Human) - ABLIM2 gene May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. Indicus|evm.model.CM009496.1.696 Q8TE82 S3TC1_HUMAN 71.969 0.925899 1.02021 SH3TC1 - SH3 domain and tetratricopeptide repeat-containing protein 1 - Homo sapiens (Human) - SH3TC1 gene Indicus|evm.model.CM009496.1.697 P83110 HTRA3_HUMAN 93.396 0.432099 0.536424 HTRA3 - Serine protease HTRA3 precursor - Homo sapiens (Human) - HTRA3 gene Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724). Indicus|evm.model.CM009496.1.698 D3ZA76 HTRA3_RAT 93.151 0.637168 0.246187 Htra3 - Serine protease HTRA3 precursor - Rattus norvegicus (Rat) - Htra3 gene Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity). Indicus|evm.model.CM009496.1.699 Q9D236 HTRA3_MOUSE 86.250 0.915709 0.568627 Htra3 - Serine protease HTRA3 precursor - Mus musculus (Mouse) - Htra3 gene Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (PubMed:15206957). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity). Indicus|evm.model.CM009497.1.1 Q96PT3 DUX5_HUMAN 50.847 0.302083 0.974619 DUX5 - Double homeobox protein 5 - Homo sapiens (Human) - DUX5 gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009497.1.3 Q03141 MARK3_MOUSE 55.208 0.969388 0.130146 Mark3 - MAP/microtubule affinity-regulating kinase 3 - Mus musculus (Mouse) - Mark3 gene Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Indicus|evm.model.CM009497.1.7 P35917 VGFR3_MOUSE 82.966 0.983333 1.01247 Flt4 - Vascular endothelial growth factor receptor 3 precursor - Mus musculus (Mouse) - Flt4 gene Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. Indicus|evm.model.CM009497.1.9 Q9ULM6 CNOT6_HUMAN 97.487 0.931323 1.07181 CNOT6 - CCR4-NOT transcription complex subunit 6 - Homo sapiens (Human) - CNOT6 gene Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. Indicus|evm.model.CM009497.1.10 Q08DQ2 GFPT2_BOVIN 100.000 0.531898 1.83871 GFPT2 - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 - Bos taurus (Bovine) - GFPT2 gene Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (By similarity). Indicus|evm.model.CM009497.1.11 Q8N431 RGF1C_HUMAN 88.780 0.890869 0.963519 RASGEF1C - Ras-GEF domain-containing family member 1C - Homo sapiens (Human) - RASGEF1C gene Guanine nucleotide exchange factor (GEF). Indicus|evm.model.CM009497.1.12 Q86XS8 GOLI_HUMAN 98.974 0.992347 0.935561 RNF130 - E3 ubiquitin-protein ligase RNF130 precursor - Homo sapiens (Human) - RNF130 gene May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. Indicus|evm.model.CM009497.1.13 Q66K14 TBC9B_HUMAN 90.677 0.96255 1.004 TBC1D9B - TBC1 domain family member 9B - Homo sapiens (Human) - TBC1D9B gene May act as a GTPase-activating protein for Rab family protein(s). Indicus|evm.model.CM009497.1.14 Q3ZBG8 MRNIP_BOVIN 99.458 0.994595 1.00271 MRNIP - MRN complex-interacting protein - Bos taurus (Bovine) - MRNIP gene Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair. Indicus|evm.model.CM009497.1.15 Q13501 SQSTM_HUMAN 92.500 0.995465 1.00227 SQSTM1 - Sequestosome-1 - Homo sapiens (Human) - SQSTM1 gene Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357). Indicus|evm.model.CM009497.1.16 Q812F8 MGT4B_MOUSE 96.512 0.980952 0.958029 Mgat4b - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B - Mus musculus (Mouse) - Mgat4b gene Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis (By similarity). Indicus|evm.model.CM009497.1.17 Q2NKS0 LTC4S_BOVIN 100.000 0.986755 1.00667 LTC4S - Leukotriene C4 synthase - Bos taurus (Bovine) - LTC4S gene Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions. Indicus|evm.model.CM009497.1.18 Q92585 MAML1_HUMAN 86.373 0.995807 0.469488 MAML1 - Mastermind-like protein 1 - Homo sapiens (Human) - MAML1 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Indicus|evm.model.CM009497.1.19 Q92585 MAML1_HUMAN 87.402 0.651163 0.380906 MAML1 - Mastermind-like protein 1 - Homo sapiens (Human) - MAML1 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Indicus|evm.model.CM009497.1.20 Q6T264 MAML1_MOUSE 81.579 0.75 0.141176 Maml1 - Mastermind-like protein 1 - Mus musculus (Mouse) - Maml1 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Indicus|evm.model.CM009497.1.21 P24643 CALX_CANLF 95.447 0.996633 1.00169 CANX - Calnexin precursor - Canis lupus familiaris (Dog) - CANX gene Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse (By similarity). Indicus|evm.model.CM009497.1.22 Q9CVN6 CBY3_MOUSE 69.347 0.804878 1.04681 Cby3 - Protein chibby homolog 3 - Mus musculus (Mouse) - Cby3 gene Indicus|evm.model.CM009497.1.23 Q5R1W4 TBA1B_PANTR 87.417 0.872093 0.381375 TUBA1B - Tubulin alpha-1B chain - Pan troglodytes (Chimpanzee) - TUBA1B gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009497.1.24 P31943 HNRH1_HUMAN 100.000 0.995556 1.00223 HNRNPH1 - Heterogeneous nuclear ribonucleoprotein H - Homo sapiens (Human) - HNRNPH1 gene This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). Indicus|evm.model.CM009497.1.25 Q96T51 RUFY1_HUMAN 90.282 0.995702 0.985876 RUFY1 - RUN and FYVE domain-containing protein 1 - Homo sapiens (Human) - RUFY1 gene Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. Indicus|evm.model.CM009497.1.29 P79331 ATS2_BOVIN 99.917 0.998342 1.00083 ADAMTS2 - A disintegrin and metalloproteinase with thrombospondin motifs 2 precursor - Bos taurus (Bovine) - ADAMTS2 gene Cleaves the propeptides of type I and II collagen prior to fibril assembly (PubMed:7622483). Does not act on type III collagen (PubMed:7622483). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity). Indicus|evm.model.CM009497.1.30 Q86Y25 Z354C_HUMAN 82.707 0.902397 1.05415 ZNF354C - Zinc finger protein 354C - Homo sapiens (Human) - ZNF354C gene May function as a transcription repressor. Binds to 5'-CCACA-3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). Indicus|evm.model.CM009497.1.31 B4DU55 ZN879_HUMAN 89.146 0.987676 1.00888 ZNF879 - Zinc finger protein 879 - Homo sapiens (Human) - ZNF879 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.32 O15303 GRM6_HUMAN 96.357 0.973624 0.994299 GRM6 - Metabotropic glutamate receptor 6 precursor - Homo sapiens (Human) - GRM6 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. Indicus|evm.model.CM009497.1.33 Q8N9F8 ZN454_HUMAN 89.038 0.988528 1.00192 ZNF454 - Zinc finger protein 454 - Homo sapiens (Human) - ZNF454 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.35 Q6ZN57 ZFP2_HUMAN 91.164 0.995699 1.00868 ZFP2 - Zinc finger protein 2 homolog - Homo sapiens (Human) - ZFP2 gene Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance. Indicus|evm.model.CM009497.1.36 Q5TA31 RN187_HUMAN 92.340 0.684211 1.45532 RNF187 - E3 ubiquitin-protein ligase RNF187 - Homo sapiens (Human) - RNF187 gene E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. Indicus|evm.model.CM009497.1.37 Q8CGP0 H2B3B_MOUSE 99.206 0.984252 1.00794 H2bu1 - Histone H2B type 3-B - Mus musculus (Mouse) - H2bu1 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009497.1.38 Q4FZT6 H2A3_RAT 77.692 0.980392 0.784615 Histone H2A type 3 - Rattus norvegicus (Rat) Indicus|evm.model.CM009497.1.39 Q6LED0 H31_RAT 97.059 0.688776 1.44118 Histone H3.1 - Rattus norvegicus (Rat) Indicus|evm.model.CM009497.1.40 Q2T9Z0 TRI17_BOVIN 94.316 0.995585 0.953684 TRIM17 - E3 ubiquitin-protein ligase TRIM17 - Bos taurus (Bovine) - TRIM17 gene May function as a ubiquitin E3 ligase. Indicus|evm.model.CM009497.1.41 A0JN74 TRI11_BOVIN 99.786 0.780936 1.27778 TRIM11 - E3 ubiquitin-protein ligase TRIM11 - Bos taurus (Bovine) - TRIM11 gene E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Indicus|evm.model.CM009497.1.42 Q6P7Q4 LGUL_RAT 89.674 0.989189 1.00543 Glo1 - Lactoylglutathione lyase - Rattus norvegicus (Rat) - Glo1 gene Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Indicus|evm.model.CM009497.1.43 Q5VST9 OBSCN_HUMAN 72.790 0.189797 1.12676 OBSCN - Obscurin - Homo sapiens (Human) - OBSCN gene Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). Indicus|evm.model.CM009497.1.45 Q5T440 CAF17_HUMAN 75.419 0.994429 1.00843 IBA57 - Putative transferase CAF17, mitochondrial precursor - Homo sapiens (Human) - IBA57 gene Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Indicus|evm.model.CM009497.1.46 Q29RK8 CXG2_BOVIN 100.000 0.14186 1.00233 GJC2 - Gap junction gamma-2 protein - Bos taurus (Bovine) - GJC2 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems (By similarity). Indicus|evm.model.CM009497.1.47 P46195 KGUA_BOVIN 100.000 0.895455 1.11111 GUK1 - Guanylate kinase - Bos taurus (Bovine) - GUK1 gene Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:8243671, PubMed:29515371, PubMed:7911663). Involved in the cGMP metabolism in photoreceptors (PubMed:29515371, PubMed:8243671). Indicus|evm.model.CM009497.1.48 P0C2B8 RM55_BOVIN 99.206 0.886525 1.11905 MRPL55 - 39S ribosomal protein L55, mitochondrial precursor - Bos taurus (Bovine) - MRPL55 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome, translation Indicus|evm.model.CM009497.1.49 Q58DU0 MMTA2_BOVIN 99.574 0.991525 1.00426 MMTAG2 - Multiple myeloma tumor-associated protein 2 homolog - Bos taurus (Bovine) - MMTAG2 gene Indicus|evm.model.CM009497.1.50 P84079 ARF1_RAT 100.000 0.989011 1.00552 Arf1 - ADP-ribosylation factor 1 - Rattus norvegicus (Rat) - Arf1 gene GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD). Indicus|evm.model.CM009497.1.51 P27467 WNT3A_MOUSE 96.951 0.942363 0.985795 Wnt3a - Protein Wnt-3a precursor - Mus musculus (Mouse) - Wnt3a gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites (PubMed:8299937). Required for normal morphogenesis of the developing neural tube (PubMed:8299937). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720). Indicus|evm.model.CM009497.1.52 Q8R5M2 WNT9A_MOUSE 95.796 0.904632 1.00548 Wnt9a - Protein Wnt-9a precursor - Mus musculus (Mouse) - Wnt9a gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development (PubMed:16818445). Plays a redundant role in maintaining joint integrity (PubMed:16818445). Indicus|evm.model.CM009497.1.53 A1L453 PRS38_HUMAN 61.639 0.89911 1.03374 PRSS38 - Serine protease 38 precursor - Homo sapiens (Human) - PRSS38 gene serine-type endopeptidase activity, proteolysis Indicus|evm.model.CM009497.1.54 P63324 RS12_RAT 72.727 0.965116 0.651515 Rps12 - 40S ribosomal protein S12 - Rattus norvegicus (Rat) - Rps12 gene cytosolic large ribosomal subunit, cytosolic small ribosomal subunit, structural constituent of ribosome, response to organonitrogen compound Indicus|evm.model.CM009497.1.55 A6QP11 SNP47_BOVIN 99.286 0.871102 1.14524 SNAP47 - Synaptosomal-associated protein 47 - Bos taurus (Bovine) - SNAP47 gene May play a role in intracellular membrane fusion. Indicus|evm.model.CM009497.1.56 Q9H9V9 JMJD4_HUMAN 75.414 0.992941 0.917927 JMJD4 - 2-oxoglutarate and iron-dependent oxygenase JMJD4 - Homo sapiens (Human) - JMJD4 gene Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. Indicus|evm.model.CM009497.1.57 Q96LW1 Z354B_HUMAN 86.297 0.996732 1 ZNF354B - Zinc finger protein 354B - Homo sapiens (Human) - ZNF354B gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.59 Q9HD20 AT131_HUMAN 94.684 0.998333 0.996678 ATP13A1 - Endoplasmic reticulum transmembrane helix translocase - Homo sapiens (Human) - ATP13A1 gene Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). Indicus|evm.model.CM009497.1.60 Q9P107 GMIP_HUMAN 84.124 0.99793 0.995876 GMIP - GEM-interacting protein - Homo sapiens (Human) - GMIP gene Stimulates, in vitro and in vivo, the GTPase activity of RhoA. Indicus|evm.model.CM009497.1.61 Q9HBW0 LPAR2_HUMAN 94.017 0.994318 1.00285 LPAR2 - Lysophosphatidic acid receptor 2 - Homo sapiens (Human) - LPAR2 gene Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. Indicus|evm.model.CM009497.1.62 Q9BYU1 PBX4_HUMAN 78.151 0.921671 1.02406 PBX4 - Pre-B-cell leukemia transcription factor 4 - Homo sapiens (Human) - PBX4 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, animal organ morphogenesis, brain development, embryonic organ development, eye development, neuron development Indicus|evm.model.CM009497.1.63 Q8IUL8 CILP2_HUMAN 87.937 0.987047 1.00173 CILP2 - Cartilage intermediate layer protein 2 precursor - Homo sapiens (Human) - CILP2 gene May play a role in cartilage scaffolding. Indicus|evm.model.CM009497.1.64 F6W8I0 YJEN3_MOUSE 79.920 0.992 0.996016 Yjefn3 - YjeF N-terminal domain-containing protein 3 - Mus musculus (Mouse) - Yjefn3 gene May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (By similarity). May play a role in spermiogenesis and oogenesis (By similarity). Indicus|evm.model.CM009497.1.65 Q95KV7 NDUAD_BOVIN 100.000 0.986207 1.00694 NDUFA13 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 - Bos taurus (Bovine) - NDUFA13 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. Indicus|evm.model.CM009497.1.66 Q9BXA6 TSSK6_HUMAN 98.535 0.992701 1.00366 TSSK6 - Testis-specific serine/threonine-protein kinase 6 - Homo sapiens (Human) - TSSK6 gene Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). Indicus|evm.model.CM009497.1.67 Q86YP4 P66A_HUMAN 92.271 0.985938 1.01106 GATAD2A - Transcriptional repressor p66-alpha - Homo sapiens (Human) - GATAD2A gene Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B. Indicus|evm.model.CM009497.1.68 Q9D2X5 SCC4_MOUSE 99.837 0.995114 0.991922 Mau2 - MAU2 chromatid cohesion factor homolog - Mus musculus (Mouse) - Mau2 gene Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodim. eric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin Plays a role in sister chromatid cohesion and normal progression through prometaphase. Indicus|evm.model.CM009497.1.69 Q8IWZ8 SUGP1_HUMAN 89.767 0.996855 0.986047 SUGP1 - SURP and G-patch domain-containing protein 1 - Homo sapiens (Human) - SUGP1 gene Plays a role in pre-mRNA splicing. Indicus|evm.model.CM009497.1.70 Q9BZW4 TM6S2_HUMAN 81.698 0.994695 1 TM6SF2 - Transmembrane 6 superfamily member 2 - Homo sapiens (Human) - TM6SF2 gene Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content (PubMed:24531328, PubMed:24927523). May function as sterol isomerase (PubMed:25566323). Indicus|evm.model.CM009497.1.71 Q86UW8 HPLN4_HUMAN 96.269 0.995037 1.00249 HAPLN4 - Hyaluronan and proteoglycan link protein 4 precursor - Homo sapiens (Human) - HAPLN4 gene Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. Indicus|evm.model.CM009497.1.72 O14594 NCAN_HUMAN 75.457 0.99854 1.03709 NCAN - Neurocan core protein precursor - Homo sapiens (Human) - NCAN gene May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. Indicus|evm.model.CM009497.1.73 Q58DU8 NR2CA_BOVIN 97.143 0.985714 1 NR2C2AP - Nuclear receptor 2C2-associated protein - Bos taurus (Bovine) - NR2C2AP gene May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. Indicus|evm.model.CM009497.1.74 O14593 RFXK_HUMAN 93.462 0.992337 1.00385 RFXANK - DNA-binding protein RFXANK - Homo sapiens (Human) - RFXANK gene Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724). May also potentiate the activation of RAF1 (By similarity). Indicus|evm.model.CM009497.1.75 Q96FH0 BORC8_HUMAN 98.319 0.983333 1.0084 BORCS8 - BLOC-1-related complex subunit 8 - Homo sapiens (Human) - BORCS8 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Indicus|evm.model.CM009497.1.76 Q02080 MEF2B_HUMAN 90.234 0.691057 1.01096 MEF2B - Myocyte-specific enhancer factor 2B - Homo sapiens (Human) - MEF2B gene Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription. Indicus|evm.model.CM009497.1.77 Q9NX61 T161A_HUMAN 91.004 0.995825 1 TMEM161A - Transmembrane protein 161A precursor - Homo sapiens (Human) - TMEM161A gene May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. Indicus|evm.model.CM009497.1.78 Q86VD7 S2542_HUMAN 92.767 0.99373 1.00314 SLC25A42 - Mitochondrial coenzyme A transporter SLC25A42 - Homo sapiens (Human) - SLC25A42 gene Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate. Indicus|evm.model.CM009497.1.80 Q8BNU0 ARMC6_MOUSE 83.940 0.993603 1.00214 Armc6 - Armadillo repeat-containing protein 6 - Mus musculus (Mouse) - Armc6 gene cytosol, hematopoietic progenitor cell differentiation Indicus|evm.model.CM009497.1.81 Q8IX01 SUGP2_HUMAN 84.182 0.956332 1.05823 SUGP2 - SURP and G-patch domain-containing protein 2 - Homo sapiens (Human) - SUGP2 gene May play a role in mRNA splicing. Indicus|evm.model.CM009497.1.82 Q9NSC5 HOME3_HUMAN 91.413 0.994429 0.99446 HOMER3 - Homer protein homolog 3 - Homo sapiens (Human) - HOMER3 gene Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). Indicus|evm.model.CM009497.1.83 Q9Y6V7 DDX49_HUMAN 94.387 0.991736 1.00207 DDX49 - Probable ATP-dependent RNA helicase DDX49 - Homo sapiens (Human) - DDX49 gene nucleoplasm, nucleus, RNA binding, positive regulation of cell growth, regulation of rRNA stability, rRNA processing Indicus|evm.model.CM009497.1.84 Q28104 COPE_BOVIN 100.000 0.4687 2.02273 COPE - Coatomer subunit epsilon - Bos taurus (Bovine) - COPE gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Indicus|evm.model.CM009497.1.85 P35621 DVR1_DANRE 100.000 0.117647 0.430986 dvr1 - Protein DVR-1 precursor - Danio rerio (Zebrafish) - dvr1 gene Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment. Indicus|evm.model.CM009497.1.86 Q92900 RENT1_HUMAN 98.763 0.982971 0.936227 UPF1 - Regulator of nonsense transcripts 1 - Homo sapiens (Human) - UPF1 gene RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability. Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA hardoring long 3'UTR by inducing the NMD machinery (By similarity). Indicus|evm.model.CM009497.1.87 P35445 COMP_BOVIN 93.651 0.997214 0.949735 COMP - Cartilage oligomeric matrix protein precursor - Bos taurus (Bovine) - COMP gene May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). Indicus|evm.model.CM009497.1.88 Q6UUV9 CRTC1_HUMAN 89.387 0.912568 1.15457 CRTC1 - CREB-regulated transcription coactivator 1 - Homo sapiens (Human) - CRTC1 gene Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. Indicus|evm.model.CM009497.1.89 Q53HC5 KLH26_HUMAN 95.777 0.962541 0.998374 KLHL26 - Kelch-like protein 26 - Homo sapiens (Human) - KLHL26 gene Indicus|evm.model.CM009497.1.90 Q0VCT2 TM59L_BOVIN 99.713 0.994286 1.00287 TMEM59L - Transmembrane protein 59-like precursor - Bos taurus (Bovine) - TMEM59L gene Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding (By similarity). Indicus|evm.model.CM009497.1.91 Q9JM58 CRLF1_MOUSE 97.814 0.914787 0.938824 Crlf1 - Cytokine receptor-like factor 1 precursor - Mus musculus (Mouse) - Crlf1 gene In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (By similarity). Plays a role in the initiation and/or maintenance of suckling in neonatal mice (PubMed:10359701). May also play a regulatory role in the immune system (By similarity). Indicus|evm.model.CM009497.1.92 Q17Q97 REX1B_BOVIN 99.444 0.98895 1.00556 REX1BD - Required for excision 1-B domain-containing protein - Bos taurus (Bovine) - REX1BD gene Indicus|evm.model.CM009497.1.93 P62986 RL40_RAT 100.000 0.984496 1.00781 Uba52 - Ubiquitin-60S ribosomal protein L40 precursor - Rattus norvegicus (Rat) - Uba52 gene Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). Indicus|evm.model.CM009497.1.94 Q3SZV2 KXDL1_BOVIN 99.432 0.91623 1.08523 KXD1 - KxDL motif-containing protein 1 - Bos taurus (Bovine) - KXD1 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May also be involved in the biogenesis of lysosome-related organelles such as melanosomes. Indicus|evm.model.CM009497.1.95 Q14318 FKBP8_HUMAN 95.204 0.949074 1.04854 FKBP8 - Peptidyl-prolyl cis-trans isomerase FKBP8 - Homo sapiens (Human) - FKBP8 gene Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Indicus|evm.model.CM009497.1.96 P55199 ELL_HUMAN 88.245 0.996759 0.993559 ELL - RNA polymerase II elongation factor ELL - Homo sapiens (Human) - ELL gene Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. Indicus|evm.model.CM009497.1.97 Q2NL29 INO1_BOVIN 99.820 0.996416 1.0018 ISYNA1 - Inositol-3-phosphate synthase 1 - Bos taurus (Bovine) - ISYNA1 gene Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). Indicus|evm.model.CM009497.1.98 Q9BWG4 SSBP4_HUMAN 89.378 0.99455 0.953247 SSBP4 - Single-stranded DNA-binding protein 4 - Homo sapiens (Human) - SSBP4 gene nucleus, positive regulation of transcription by RNA polymerase II Indicus|evm.model.CM009497.1.99 Q8MII8 LRC25_BOVIN 98.371 0.993485 1 LRRC25 - Leucine-rich repeat-containing protein 25 precursor - Bos taurus (Bovine) - LRRC25 gene Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy. Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. Indicus|evm.model.CM009497.1.100 Q99988 GDF15_HUMAN 65.273 0.993528 1.00325 GDF15 - Growth/differentiation factor 15 precursor - Homo sapiens (Human) - GDF15 gene Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity). Indicus|evm.model.CM009497.1.101 Q9NXJ5 PGPI_HUMAN 95.610 0.985507 0.990431 PGPEP1 - Pyroglutamyl-peptidase 1 - Homo sapiens (Human) - PGPEP1 gene Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Indicus|evm.model.CM009497.1.102 P02301 H3C_MOUSE 98.936 0.645833 1.05882 H3-5 - Histone H3.3C - Mus musculus (Mouse) - H3-5 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009497.1.103 Q9Y4Z0 LSM4_HUMAN 100.000 0.901316 1.09353 LSM4 - U6 snRNA-associated Sm-like protein LSm4 - Homo sapiens (Human) - LSM4 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Indicus|evm.model.CM009497.1.104 Q8WNU4 IQCN_MACFA 52.367 0.943574 0.273585 IQCN - IQ domain-containing protein N - Macaca fascicularis (Crab-eating macaque) - IQCN gene Indicus|evm.model.CM009497.1.105 A7YY54 JUND_BOVIN 99.669 0.993399 0.873199 JUND - Transcription factor jun-D - Bos taurus (Bovine) - JUND gene Transcription factor binding AP-1 sites. Indicus|evm.model.CM009497.1.106 Q9H0B3 IQCN_HUMAN 52.362 0.336022 1.26102 IQCN - IQ domain-containing protein N - Homo sapiens (Human) - IQCN gene mitochondrion, nucleus Indicus|evm.model.CM009497.1.107 Q8WNU4 IQCN_MACFA 52.105 0.162813 0.890223 IQCN - IQ domain-containing protein N - Macaca fascicularis (Crab-eating macaque) - IQCN gene Indicus|evm.model.CM009497.1.108 P14644 PDE4C_RAT 82.443 0.538066 1.81343 Pde4c - cAMP-specific 3',5'-cyclic phosphodiesterase 4C - Rattus norvegicus (Rat) - Pde4c gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Indicus|evm.model.CM009497.1.109 P11023 RAB3A_BOVIN 100.000 0.793478 1.25455 RAB3A - Ras-related protein Rab-3A - Bos taurus (Bovine) - RAB3A gene Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity). Indicus|evm.model.CM009497.1.110 A5D787 M17L2_BOVIN 99.541 0.92735 1.07339 MPV17L2 - Mpv17-like protein 2 - Bos taurus (Bovine) - MPV17L2 gene Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity). Indicus|evm.model.CM009497.1.111 P23726 P85B_BOVIN 100.000 0.77451 1.26796 PIK3R2 - Phosphatidylinositol 3-kinase regulatory subunit beta - Bos taurus (Bovine) - PIK3R2 gene Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. Promotes nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). Indicus|evm.model.CM009497.1.113 O60307 MAST3_HUMAN 89.275 0.998513 1.0275 MAST3 - Microtubule-associated serine/threonine-protein kinase 3 - Homo sapiens (Human) - MAST3 gene protein serine/threonine kinase activity, cytoskeleton organization, intracellular signal transduction, peptidyl-serine phosphorylation Indicus|evm.model.CM009497.1.114 P42701 I12R1_HUMAN 71.273 0.884457 1.09819 IL12RB1 - Interleukin-12 receptor subunit beta-1 precursor - Homo sapiens (Human) - IL12RB1 gene Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Indicus|evm.model.CM009497.1.115 Q8TBH0 ARRD2_HUMAN 80.348 0.98263 0.990172 ARRDC2 - Arrestin domain-containing protein 2 - Homo sapiens (Human) - ARRDC2 gene cytoplasm, cytoplasmic vesicle, plasma membrane, protein transport Indicus|evm.model.CM009497.1.116 Q92952 KCNN1_HUMAN 91.897 0.809309 1.22652 KCNN1 - Small conductance calcium-activated potassium channel protein 1 - Homo sapiens (Human) - KCNN1 gene Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity). Indicus|evm.model.CM009497.1.117 Q2TBV6 CC124_BOVIN 100.000 0.991071 1.00448 CCDC124 - Coiled-coil domain-containing protein 124 - Bos taurus (Bovine) - CCDC124 gene Required for proper progression of late cytokinetic stages. Indicus|evm.model.CM009497.1.118 Q92911 SC5A5_HUMAN 88.455 0.973466 0.937792 SLC5A5 - Sodium/iodide cotransporter - Homo sapiens (Human) - SLC5A5 gene Mediates iodide uptake in the thyroid gland. Indicus|evm.model.CM009497.1.119 Q02543 RL18A_HUMAN 100.000 0.988701 1.00568 RPL18A - 60S ribosomal protein L18a - Homo sapiens (Human) - RPL18A gene cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing Indicus|evm.model.CM009497.1.120 P52333 JAK3_HUMAN 90.397 0.993572 0.968861 JAK3 - Tyrosine-protein kinase JAK3 - Homo sapiens (Human) - JAK3 gene Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. Indicus|evm.model.CM009497.1.121 O77801 INSL3_BOVIN 99.242 0.984962 1.00758 INSL3 - Insulin-like 3 precursor - Bos taurus (Bovine) - INSL3 gene Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). Indicus|evm.model.CM009497.1.122 Q9Y2A9 B3GN3_HUMAN 72.849 0.994638 1.00269 B3GNT3 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 - Homo sapiens (Human) - B3GNT3 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191). Indicus|evm.model.CM009497.1.123 O14526 FCHO1_HUMAN 89.174 0.997765 1.00675 FCHO1 - F-BAR domain only protein 1 - Homo sapiens (Human) - FCHO1 gene Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Indicus|evm.model.CM009497.1.124 A6QQ70 MAP1S_BOVIN 99.531 0.998126 1.00094 MAP1S - Microtubule-associated protein 1S - Bos taurus (Bovine) - MAP1S gene Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). Indicus|evm.model.CM009497.1.125 Q9UPW8 UN13A_HUMAN 95.853 0.998812 0.988256 UNC13A - Protein unc-13 homolog A - Homo sapiens (Human) - UNC13A gene Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed:23999003). Indicus|evm.model.CM009497.1.126 A5PK45 GT251_BOVIN 99.839 0.996795 1.00161 COLGALT1 - Procollagen galactosyltransferase 1 precursor - Bos taurus (Bovine) - COLGALT1 gene Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix. Also involved in the biosynthesis of collagen type IV. Indicus|evm.model.CM009497.1.127 Q86XR2 NIBA3_HUMAN 80.789 0.993174 0.840746 NIBAN3 - Protein Niban 3 - Homo sapiens (Human) - NIBAN3 gene Indicus|evm.model.CM009497.1.128 Q2TBQ8 6PGL_BOVIN 99.612 0.992278 1.00388 PGLS - 6-phosphogluconolactonase - Bos taurus (Bovine) - PGLS gene Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. Indicus|evm.model.CM009497.1.129 Q3ZKN0 S27A1_BOVIN 99.690 0.97432 1.02477 SLC27A1 - Long-chain fatty acid transport protein 1 - Bos taurus (Bovine) - SLC27A1 gene Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier (By similarity). Indicus|evm.model.CM009497.1.130 Q96CM4 NXNL1_HUMAN 86.911 0.86758 1.03302 NXNL1 - Nucleoredoxin-like protein 1 - Homo sapiens (Human) - NXNL1 gene Plays an important role in retinal cone photoreceptor survival (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity). Indicus|evm.model.CM009497.1.131 A6NGB7 TM221_HUMAN 81.100 0.993151 1.00344 TMEM221 - Transmembrane protein 221 - Homo sapiens (Human) - TMEM221 gene Indicus|evm.model.CM009497.1.132 Q3T0N1 MB12A_BOVIN 100.000 0.992701 1.00366 MVB12A - Multivesicular body subunit 12A - Bos taurus (Bovine) - MVB12A gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity). Indicus|evm.model.CM009497.1.133 Q8R2Q8 BST2_MOUSE 45.455 0.577922 0.895349 Bst2 - Bone marrow stromal antigen 2 precursor - Mus musculus (Mouse) - Bst2 gene IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Indicus|evm.model.CM009497.1.134 Q10589 BST2_HUMAN 50.485 0.556818 0.977778 BST2 - Bone marrow stromal antigen 2 precursor - Homo sapiens (Human) - BST2 gene IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted (PubMed:22520941, PubMed:21529378, PubMed:20940320, PubMed:20419159, PubMed:20399176, PubMed:19879838, PubMed:19036818, PubMed:18342597, PubMed:18200009). Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV (PubMed:22520941, PubMed:21621240, PubMed:21529378, PubMed:20943977, PubMed:20686043, PubMed:20419159, PubMed:20399176, PubMed:19879838, PubMed:19179289, PubMed:18342597, PubMed:18200009, PubMed:26378163, PubMed:31199522). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration (PubMed:22065321). Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed:23028328). Indicus|evm.model.CM009497.1.135 A0A1B0GVG4 CC194_HUMAN 78.313 0.585106 1.20513 CCDC194 - Coiled-coil domain-containing protein 194 precursor - Homo sapiens (Human) - CCDC194 gene Indicus|evm.model.CM009497.1.136 Q9BX97 PLVAP_HUMAN 75.566 0.995485 1.00226 PLVAP - Plasmalemma vesicle-associated protein - Homo sapiens (Human) - PLVAP gene Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. Indicus|evm.model.CM009497.1.137 Q969Y2 GTPB3_HUMAN 87.854 0.855652 1.1687 GTPBP3 - tRNA modification GTPase GTPBP3, mitochondrial precursor - Homo sapiens (Human) - GTPBP3 gene GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Indicus|evm.model.CM009497.1.139 Q9HCE9 ANO8_HUMAN 84.826 0.998288 0.948052 ANO8 - Anoctamin-8 - Homo sapiens (Human) - ANO8 gene Does not exhibit calcium-activated chloride channel (CaCC) activity. Indicus|evm.model.CM009497.1.140 Q5RD86 DDA1_PONAB 100.000 0.980583 1.0098 DDA1 - DET1- and DDB1-associated protein 1 - Pongo abelii (Sumatran orangutan) - DDA1 gene Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex. Indicus|evm.model.CM009497.1.141 Q17QP1 ABHD8_BOVIN 100.000 0.995381 1.00231 ABHD8 - Protein ABHD8 - Bos taurus (Bovine) - ABHD8 gene mitochondrion, carboxylic ester hydrolase activity, lysophosphatidic acid acyltransferase activity, lipid homeostasis, phosphatidic acid biosynthetic process Indicus|evm.model.CM009497.1.142 Q8NAG6 ANKL1_HUMAN 67.197 0.908133 1.07967 ANKLE1 - Ankyrin repeat and LEM domain-containing protein 1 - Homo sapiens (Human) - ANKLE1 gene Endonuclease that probably plays a role in the DNA damage response and DNA repair. Indicus|evm.model.CM009497.1.143 Q08E57 BABA1_BOVIN 100.000 0.993994 1.00301 BABAM1 - BRISC and BRCA1-A complex member 1 - Bos taurus (Bovine) - BABAM1 gene Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Indicus|evm.model.CM009497.1.144 Q8N6Y0 USBP1_HUMAN 76.102 0.997139 0.99431 USHBP1 - Usher syndrome type-1C protein-binding protein 1 - Homo sapiens (Human) - USHBP1 gene PDZ domain binding Indicus|evm.model.CM009497.1.145 P10588 NR2F6_HUMAN 95.894 0.995157 1.02228 NR2F6 - Nuclear receptor subfamily 2 group F member 6 - Homo sapiens (Human) - NR2F6 gene Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Indicus|evm.model.CM009497.1.146 Q9H607 OCEL1_HUMAN 78.365 0.990338 0.784091 OCEL1 - Occludin/ELL domain-containing protein 1 - Homo sapiens (Human) - OCEL1 gene Indicus|evm.model.CM009497.1.147 Q9NZ43 USE1_HUMAN 93.846 0.945255 1.05792 USE1 - Vesicle transport protein USE1 - Homo sapiens (Human) - USE1 gene SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Indicus|evm.model.CM009497.1.148 Q13459 MYO9B_HUMAN 85.477 0.999074 1.00139 MYO9B - Unconventional myosin-IXb - Homo sapiens (Human) - MYO9B gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). Indicus|evm.model.CM009497.1.149 Q9BT25 HAUS8_HUMAN 66.846 0.991892 0.902439 HAUS8 - HAUS augmin-like complex subunit 8 - Homo sapiens (Human) - HAUS8 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Indicus|evm.model.CM009497.1.151 Q8IZJ3 CPMD8_HUMAN 84.938 0.984941 0.951194 CPAMD8 - C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 precursor - Homo sapiens (Human) - CPAMD8 gene eye development Indicus|evm.model.CM009497.1.152 Q96RI0 PAR4_HUMAN 77.403 0.994737 0.987013 F2RL3 - Proteinase-activated receptor 4 precursor - Homo sapiens (Human) - F2RL3 gene Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. Indicus|evm.model.CM009497.1.153 O75182 SIN3B_HUMAN 92.287 0.970614 0.966437 SIN3B - Paired amphipathic helix protein Sin3b - Homo sapiens (Human) - SIN3B gene Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. Indicus|evm.model.CM009497.1.154 Q149M9 NWD1_HUMAN 81.859 0.984733 1.00512 NWD1 - NACHT domain- and WD repeat-containing protein 1 - Homo sapiens (Human) - NWD1 gene May play a role in the control of androgen receptor (AR) protein steady-state levels. Indicus|evm.model.CM009497.1.155 A4FV75 TM38A_BOVIN 99.331 0.993333 1.00334 TMEM38A - Trimeric intracellular cation channel type A - Bos taurus (Bovine) - TMEM38A gene Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Indicus|evm.model.CM009497.1.156 Q3SZ97 SMIM7_BOVIN 100.000 0.972222 0.96 SMIM7 - Small integral membrane protein 7 precursor - Bos taurus (Bovine) - SMIM7 gene Indicus|evm.model.CM009497.1.157 A5PK23 MED26_BOVIN 100.000 0.996667 1.00167 MED26 - Mediator of RNA polymerase II transcription subunit 26 - Bos taurus (Bovine) - MED26 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009497.1.158 Q96K37 S35E1_HUMAN 96.486 0.893462 1.00732 SLC35E1 - Solute carrier family 35 member E1 - Homo sapiens (Human) - SLC35E1 gene Putative transporter. Indicus|evm.model.CM009497.1.159 Q8IWX8 CHERP_HUMAN 97.162 0.997819 1.00109 CHERP - Calcium homeostasis endoplasmic reticulum protein - Homo sapiens (Human) - CHERP gene Involved in calcium homeostasis, growth and proliferation. Indicus|evm.model.CM009497.1.160 Q9H6X5 CS044_HUMAN 75.124 0.99005 0.305936 C19orf44 - Uncharacterized protein C19orf44 - Homo sapiens (Human) - C19orf44 gene Indicus|evm.model.CM009497.1.161 P30050 RL12_HUMAN 94.545 0.987952 1.00606 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Indicus|evm.model.CM009497.1.162 Q9H6X5 CS044_HUMAN 58.594 0.696629 0.541857 C19orf44 - Uncharacterized protein C19orf44 - Homo sapiens (Human) - C19orf44 gene Indicus|evm.model.CM009497.1.163 Q2TBR8 CALR3_BOVIN 99.479 0.896956 1.11198 CALR3 - Calreticulin-3 precursor - Bos taurus (Bovine) - CALR3 gene During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity). Indicus|evm.model.CM009497.1.164 Q9UBC2 EP15R_HUMAN 93.155 0.945115 1.0544 EPS15L1 - Epidermal growth factor receptor substrate 15-like 1 - Homo sapiens (Human) - EPS15L1 gene Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. Indicus|evm.model.CM009497.1.165 Q9Y5W3 KLF2_HUMAN 98.095 0.497608 0.588732 KLF2 - Krueppel-like factor 2 - Homo sapiens (Human) - KLF2 gene Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758). Indicus|evm.model.CM009497.1.167 Q9BXS5 AP1M1_HUMAN 100.000 0.995283 1.00236 AP1M1 - AP-1 complex subunit mu-1 - Homo sapiens (Human) - AP1M1 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Indicus|evm.model.CM009497.1.168 Q5R9E5 FA32A_PONAB 100.000 0.982301 1.00893 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Indicus|evm.model.CM009497.1.169 Q96Q77 CIB3_HUMAN 97.386 0.980645 0.828877 CIB3 - Calcium and integrin-binding family member 3 - Homo sapiens (Human) - CIB3 gene calcium ion binding, magnesium ion binding Indicus|evm.model.CM009497.1.170 Q96JZ2 HSH2D_HUMAN 57.923 0.994169 0.974432 HSH2D - Hematopoietic SH2 domain-containing protein - Homo sapiens (Human) - HSH2D gene May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. Indicus|evm.model.CM009497.1.171 A4FV54 RAB8A_BOVIN 100.000 0.990385 1.00483 RAB8A - Ras-related protein Rab-8A precursor - Bos taurus (Bovine) - RAB8A gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B and RAB11A participates in epithelial cell polarization (By similarity). May be involved in ciliogenesis (By similarity). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (By similarity). Indicus|evm.model.CM009497.1.172 Q01173 TPM1_XENLA 81.338 0.992982 1.00352 tpm1 - Tropomyosin alpha-1 chain - Xenopus laevis (African clawed frog) - tpm1 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Indicus|evm.model.CM009497.1.174 Q9Y4A9 O10H1_HUMAN 76.786 0.611111 0.283019 OR10H1 - Olfactory receptor 10H1 - Homo sapiens (Human) - OR10H1 gene Odorant receptor. Indicus|evm.model.CM009497.1.175 Q9Y4A9 O10H1_HUMAN 69.014 0.864198 0.254717 OR10H1 - Olfactory receptor 10H1 - Homo sapiens (Human) - OR10H1 gene Odorant receptor. Indicus|evm.model.CM009497.1.176 Q9GLL1 CP4F_SHEEP 81.636 0.996317 1.02841 CYP4F21 - Prostaglandin E2 omega-hydroxylase CYP4F21 precursor - Ovis aries (Sheep) - CYP4F21 gene A cytochrome P450 monooxygenase that catalyzes the omega-hydroxylation of prostaglandin E2. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.CM009497.1.177 Q9GLL1 CP4F_SHEEP 83.176 0.981203 1.00758 CYP4F21 - Prostaglandin E2 omega-hydroxylase CYP4F21 precursor - Ovis aries (Sheep) - CYP4F21 gene A cytochrome P450 monooxygenase that catalyzes the omega-hydroxylation of prostaglandin E2. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.CM009497.1.178 P78329 CP4F2_HUMAN 81.731 0.98855 1.00769 CYP4F2 - Cytochrome P450 4F2 precursor - Homo sapiens (Human) - CYP4F2 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:18577768, PubMed:10833273, PubMed:10660572, PubMed:11997390, PubMed:17341693, PubMed:18574070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) (PubMed:18577768). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10660572, PubMed:17341693, PubMed:18574070). Plays a role in the oxidative inactivation of eicosanoids, including both proinflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:8026587, PubMed:9799565, PubMed:10833273, PubMed:10660572, PubMed:17341693, PubMed:18574070, PubMed:18577768). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids (PubMed:18065749). Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites (PubMed:15145985). Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening (PubMed:16547005, PubMed:18182499). Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues (PubMed:11997390). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:19297519, PubMed:24138531). Indicus|evm.model.CM009497.1.179 P78329 CP4F2_HUMAN 73.090 0.989673 1.11731 CYP4F2 - Cytochrome P450 4F2 precursor - Homo sapiens (Human) - CYP4F2 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:18577768, PubMed:10833273, PubMed:10660572, PubMed:11997390, PubMed:17341693, PubMed:18574070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) (PubMed:18577768). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10660572, PubMed:17341693, PubMed:18574070). Plays a role in the oxidative inactivation of eicosanoids, including both proinflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:8026587, PubMed:9799565, PubMed:10833273, PubMed:10660572, PubMed:17341693, PubMed:18574070, PubMed:18577768). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids (PubMed:18065749). Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites (PubMed:15145985). Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening (PubMed:16547005, PubMed:18182499). Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues (PubMed:11997390). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:19297519, PubMed:24138531). Indicus|evm.model.CM009497.1.180 P78329 CP4F2_HUMAN 83.654 0.988571 1.00962 CYP4F2 - Cytochrome P450 4F2 precursor - Homo sapiens (Human) - CYP4F2 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:18577768, PubMed:10833273, PubMed:10660572, PubMed:11997390, PubMed:17341693, PubMed:18574070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) (PubMed:18577768). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10660572, PubMed:17341693, PubMed:18574070). Plays a role in the oxidative inactivation of eicosanoids, including both proinflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:8026587, PubMed:9799565, PubMed:10833273, PubMed:10660572, PubMed:17341693, PubMed:18574070, PubMed:18577768). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids (PubMed:18065749). Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites (PubMed:15145985). Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening (PubMed:16547005, PubMed:18182499). Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues (PubMed:11997390). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:19297519, PubMed:24138531). Indicus|evm.model.CM009497.1.182 P51871 CP4F6_RAT 79.079 0.992352 0.973929 Cyp4f6 - Cytochrome P450 4F6 - Rattus norvegicus (Rat) - Cyp4f6 gene inflammatory response, leukotriene metabolic process Indicus|evm.model.CM009497.1.183 Q6NT55 CP4FN_HUMAN 92.844 0.996241 1.00188 CYP4F22 - Cytochrome P450 4F22 - Homo sapiens (Human) - CYP4F22 gene A cytochrome P450 monooxygenase involved in epidermal ceramide biosynthesis. Hydroxylates the terminal carbon (omega-hydroxylation) of ultra-long-chain fatty acyls (C28-C36) prior to ceramide synthesis (PubMed:26056268). Contributes to the synthesis of three classes of omega-hydroxy-ultra-long chain fatty acylceramides having sphingosine, 6-hydroxysphingosine and phytosphingosine bases, all major lipid components that underlie the permeability barrier of the stratum corneum (PubMed:26056268). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:26056268). Indicus|evm.model.CM009497.1.184 Q866Y3 PGRP2_PIG 79.431 0.996622 0.989967 PGLYRP2 - N-acetylmuramoyl-L-alanine amidase precursor - Sus scrofa (Pig) - PGLYRP2 gene May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity. Indicus|evm.model.CM009497.1.185 A6QQ91 RASL3_BOVIN 99.802 0.998026 1.00099 RASAL3 - RAS protein activator like-3 - Bos taurus (Bovine) - RASAL3 gene Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. Indicus|evm.model.CM009497.1.186 O95785 WIZ_HUMAN 79.771 0.392105 1.15082 WIZ - Protein Wiz - Homo sapiens (Human) - WIZ gene May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). Indicus|evm.model.CM009497.1.187 Q9ULX6 AKP8L_HUMAN 90.909 0.996909 1.00155 AKAP8L - A-kinase anchor protein 8-like - Homo sapiens (Human) - AKAP8L gene Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). Indicus|evm.model.CM009497.1.188 O43823 AKAP8_HUMAN 83.862 0.997076 0.988439 AKAP8 - A-kinase anchor protein 8 - Homo sapiens (Human) - AKAP8 gene Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). Indicus|evm.model.CM009497.1.189 O60885 BRD4_HUMAN 96.730 0.560398 0.960352 BRD4 - Bromodomain-containing protein 4 - Homo sapiens (Human) - BRD4 gene Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). Indicus|evm.model.CM009497.1.190 Q9H6B9 EPHX3_HUMAN 89.722 0.99446 1.00278 EPHX3 - Epoxide hydrolase 3 - Homo sapiens (Human) - EPHX3 gene Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin. Indicus|evm.model.CM009497.1.191 Q9UM47 NOTC3_HUMAN 93.141 0.980712 1.00517 NOTCH3 - Neurogenic locus notch homolog protein 3 precursor - Homo sapiens (Human) - NOTCH3 gene Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Indicus|evm.model.CM009497.1.192 Q920A7 AFG31_MOUSE 73.506 0.879245 0.671736 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Indicus|evm.model.CM009497.1.193 A6QQT9 HACL2_BOVIN 100.000 0.99684 1.00158 ILVBL - 2-hydroxyacyl-CoA lyase 2 - Bos taurus (Bovine) - ILVBL gene Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. Indicus|evm.model.CM009497.1.194 D3ZZN9 SYDE1_RAT 88.828 0.787572 0.941497 Syde1 - Rho GTPase-activating protein SYDE1 - Rattus norvegicus (Rat) - Syde1 gene GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1. Indicus|evm.model.CM009497.1.195 O60431 OR1I1_HUMAN 84.507 0.985915 0.2 OR1I1 - Olfactory receptor 1I1 - Homo sapiens (Human) - OR1I1 gene Odorant receptor. Indicus|evm.model.CM009497.1.196 P31944 CASPE_HUMAN 80.672 0.933071 1.04959 CASP14 - Caspase-14 precursor - Homo sapiens (Human) - CASP14 gene Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736). Indicus|evm.model.CM009497.1.197 Q2YDN4 CC105_BOVIN 99.200 0.996008 1.002 CCDC105 - Coiled-coil domain-containing protein 105 - Bos taurus (Bovine) - CCDC105 gene Indicus|evm.model.CM009497.1.198 Q9N1R2 EAA4_CANLF 80.531 0.996086 0.906028 SLC1A6 - Excitatory amino acid transporter 4 - Canis lupus familiaris (Dog) - SLC1A6 gene Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Indicus|evm.model.CM009497.1.199 Q8NGA2 OR7A2_HUMAN 80.357 0.956897 0.374194 OR7A2P - Putative olfactory receptor 7A2 - Homo sapiens (Human) - OR7A2P gene Odorant receptor. Indicus|evm.model.CM009497.1.200 Q93062 RBPMS_HUMAN 97.959 0.96 0.255102 RBPMS - RNA-binding protein with multiple splicing - Homo sapiens (Human) - RBPMS gene Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403). Indicus|evm.model.CM009497.1.203 O14581 OR7AH_HUMAN 77.517 0.980198 0.980583 OR7A17 - Olfactory receptor 7A17 - Homo sapiens (Human) - OR7A17 gene Odorant receptor. Indicus|evm.model.CM009497.1.204 O76100 OR7AA_HUMAN 70.500 0.99005 0.650485 OR7A10 - Olfactory receptor 7A10 - Homo sapiens (Human) - OR7A10 gene Odorant receptor. Indicus|evm.model.CM009497.1.205 Q58CS8 GNPTG_BOVIN 96.532 0.735043 0.764706 GNPTG - N-acetylglucosamine-1-phosphotransferase subunit gamma precursor - Bos taurus (Bovine) - GNPTG gene Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors (By similarity). Indicus|evm.model.CM009497.1.206 Q9MYN5 CDKN3_PIG 92.500 0.603053 0.617925 CDKN3 - Cyclin-dependent kinase inhibitor 3 - Sus scrofa (Pig) - CDKN3 gene May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity). Indicus|evm.model.CM009497.1.207 Q2Q421 AGRE2_CANLF 76.667 0.776316 0.0915663 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Canis lupus familiaris (Dog) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Indicus|evm.model.CM009497.1.208 Q2Q426 AGRE2_MACMU 71.656 0.993651 0.383212 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Macaca mulatta (Rhesus macaque) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Indicus|evm.model.CM009497.1.209 Q9UHX3 AGRE2_HUMAN 51.961 0.469767 0.261239 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Homo sapiens (Human) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242). Indicus|evm.model.CM009497.1.211 O76100 OR7AA_HUMAN 73.410 0.99422 0.559871 OR7A10 - Olfactory receptor 7A10 - Homo sapiens (Human) - OR7A10 gene Odorant receptor. Indicus|evm.model.CM009497.1.214 Q2Q426 AGRE2_MACMU 59.524 0.0503067 0.991484 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Macaca mulatta (Rhesus macaque) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Indicus|evm.model.CM009497.1.215 Q8SQA4 AGRE5_BOVIN 83.969 0.123457 1.4346 ADGRE5 - Adhesion G protein-coupled receptor E5 precursor - Bos taurus (Bovine) - ADGRE5 gene Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. Indicus|evm.model.CM009497.1.216 Q2Q421 AGRE2_CANLF 68.608 0.788932 0.936145 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Canis lupus familiaris (Dog) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Indicus|evm.model.CM009497.1.217 P48960 AGRE5_HUMAN 64.646 0.464455 0.252695 ADGRE5 - Adhesion G protein-coupled receptor E5 precursor - Homo sapiens (Human) - ADGRE5 gene Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. Indicus|evm.model.CM009497.1.218 Q2Q421 AGRE2_CANLF 69.083 0.960663 0.581928 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Canis lupus familiaris (Dog) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Indicus|evm.model.CM009497.1.219 Q9UHX3 AGRE2_HUMAN 58.871 0.900763 0.159174 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Homo sapiens (Human) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242). Indicus|evm.model.CM009497.1.221 Q96JL9 ZN333_HUMAN 65.988 0.825721 1.25113 ZNF333 - Zinc finger protein 333 - Homo sapiens (Human) - ZNF333 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.222 Q9BY15 AGRE3_HUMAN 71.835 0.714777 1.33896 ADGRE3 - Adhesion G protein-coupled receptor E3 precursor - Homo sapiens (Human) - ADGRE3 gene Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils. Indicus|evm.model.CM009497.1.223 Q6ZS10 CL17A_HUMAN 65.232 0.908228 0.835979 CLEC17A - C-type lectin domain family 17, member A - Homo sapiens (Human) - CLEC17A gene Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues. Indicus|evm.model.CM009497.1.224 Q02368 NDUB7_BOVIN 100.000 0.985507 1.0073 NDUFB7 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 - Bos taurus (Bovine) - NDUFB7 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009497.1.225 Q3ZCD7 TECR_BOVIN 100.000 0.993528 1.00325 TECR - Very-long-chain enoyl-CoA reductase - Bos taurus (Bovine) - TECR gene Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (By similarity). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (By similarity). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (By similarity). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (By similarity). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (By similarity). Indicus|evm.model.CM009497.1.226 Q3MI00 DNJB1_BOVIN 100.000 0.994135 1.00294 DNAJB1 - DnaJ homolog subfamily B member 1 - Bos taurus (Bovine) - DNAJB1 gene Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Indicus|evm.model.CM009497.1.227 O14908 GIPC1_HUMAN 97.898 0.994012 1.003 GIPC1 - PDZ domain-containing protein GIPC1 - Homo sapiens (Human) - GIPC1 gene May be involved in G protein-linked signaling. Indicus|evm.model.CM009497.1.228 Q9BGL8 PE2R1_CANLF 92.568 0.383812 0.950372 PTGER1 - Prostaglandin E2 receptor EP1 subtype - Canis lupus familiaris (Dog) - PTGER1 gene Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues (By similarity). Indicus|evm.model.CM009497.1.229 A1A4I4 PKN1_BOVIN 99.681 0.98633 1.00742 PKN1 - Serine/threonine-protein kinase N1 - Bos taurus (Bovine) - PKN1 gene PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. Indicus|evm.model.CM009497.1.230 Q8VDW0 DX39A_MOUSE 97.892 0.995327 1.00234 Ddx39a - ATP-dependent RNA helicase DDX39A - Mus musculus (Mouse) - Ddx39a gene Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus (By similarity). Indicus|evm.model.CM009497.1.231 Q8SQA4 AGRE5_BOVIN 83.676 0.997585 1.12807 ADGRE5 - Adhesion G protein-coupled receptor E5 precursor - Bos taurus (Bovine) - ADGRE5 gene Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. Indicus|evm.model.CM009497.1.232 O97831 AGRL1_BOVIN 99.864 0.998642 1.00068 ADGRL1 - Adhesion G protein-coupled receptor L1 precursor - Bos taurus (Bovine) - ADGRL1 gene Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). Indicus|evm.model.CM009497.1.233 Q17QJ0 ASF1B_BOVIN 100.000 0.990148 1.00495 ASF1B - Histone chaperone ASF1B - Bos taurus (Bovine) - ASF1B gene Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (By similarity). Indicus|evm.model.CM009497.1.234 P00517 KAPCA_BOVIN 98.529 0.546774 1.76638 PRKACA - cAMP-dependent protein kinase catalytic subunit alpha - Bos taurus (Bovine) - PRKACA gene Phosphorylates a large number of substrates in the cytoplasm and the nucleus (By similarity). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (By similarity). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (By similarity). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis (By similarity). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (By similarity). Indicus|evm.model.CM009497.1.235 Q8CF25 CS067_MOUSE 87.189 0.777778 1.19601 UPF0575 protein C19orf67 homolog - Mus musculus (Mouse) Indicus|evm.model.CM009497.1.236 Q96FF7 MISP3_HUMAN 82.407 0.986239 0.995434 MISP3 - Uncharacterized protein MISP3 - Homo sapiens (Human) - MISP3 gene Indicus|evm.model.CM009497.1.237 A6NDB9 PALM3_HUMAN 66.849 0.693316 1.13373 PALM3 - Paralemmin-3 precursor - Homo sapiens (Human) - PALM3 gene ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. Indicus|evm.model.CM009497.1.238 Q6UWB1 I27RA_HUMAN 72.178 0.952672 1.02987 IL27RA - Interleukin-27 receptor subunit alpha precursor - Homo sapiens (Human) - IL27RA gene Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. Indicus|evm.model.CM009497.1.239 P11953 RELX_SQUAC 90.909 0.154412 2.51852 Relaxin - Squalus acanthias (Spiny dogfish) Indicus|evm.model.CM009497.1.240 P22670 RFX1_HUMAN 92.889 0.529551 0.432074 RFX1 - MHC class II regulatory factor RFX1 - Homo sapiens (Human) - RFX1 gene Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. Indicus|evm.model.CM009497.1.241 P22670 RFX1_HUMAN 88.182 0.951754 0.232891 RFX1 - MHC class II regulatory factor RFX1 - Homo sapiens (Human) - RFX1 gene Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. Indicus|evm.model.CM009497.1.242 P22670 RFX1_HUMAN 94.638 0.994652 0.382022 RFX1 - MHC class II regulatory factor RFX1 - Homo sapiens (Human) - RFX1 gene Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. Indicus|evm.model.CM009497.1.243 Q3SZD5 DCA15_BOVIN 100.000 0.996672 1.00167 DCAF15 - DDB1- and CUL4-associated factor 15 - Bos taurus (Bovine) - DCAF15 gene Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins. The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3. May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells. Indicus|evm.model.CM009497.1.244 Q6PEZ8 PONL1_HUMAN 91.009 0.765993 1.16016 PODNL1 - Podocan-like protein 1 precursor - Homo sapiens (Human) - PODNL1 gene extracellular space Indicus|evm.model.CM009497.1.245 Q6P1N0 C2D1A_HUMAN 91.377 0.997899 1.00105 CC2D1A - Coiled-coil and C2 domain-containing protein 1A - Homo sapiens (Human) - CC2D1A gene Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. Indicus|evm.model.CM009497.1.247 Q0VDD7 BRME1_HUMAN 46.926 0.938193 0.944611 BRME1 - Break repair meiotic recombinase recruitment factor 1 - Homo sapiens (Human) - BRME1 gene Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. Indicus|evm.model.CM009497.1.248 Q5EA37 CC130_BOVIN 99.407 0.691358 1.215 CCDC130 - Coiled-coil domain-containing protein 130 - Bos taurus (Bovine) - CCDC130 gene post-mRNA release spliceosomal complex, U2-type spliceosomal complex, RNA splicing Indicus|evm.model.CM009497.1.249 Q2NL31 MTNA_BOVIN 100.000 0.994429 1.00279 MRI1 - Methylthioribose-1-phosphate isomerase - Bos taurus (Bovine) - MRI1 gene Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Indicus|evm.model.CM009497.1.250 Q148I0 L10K_BOVIN 100.000 0.979798 1.0102 Leydig cell tumor 10 kDa protein homolog - Bos taurus (Bovine) Indicus|evm.model.CM009497.1.251 Q9H7M6 ZSWM4_HUMAN 96.477 0.537489 1.11931 ZSWIM4 - Zinc finger SWIM domain-containing protein 4 - Homo sapiens (Human) - ZSWIM4 gene Cul2-RING ubiquitin ligase complex, regulation of axon guidance Indicus|evm.model.CM009497.1.252 P13994 CC130_HUMAN 94.000 0.379845 0.325758 CCDC130 - Coiled-coil domain-containing protein 130 - Homo sapiens (Human) - CCDC130 gene post-mRNA release spliceosomal complex, U2-type spliceosomal complex, response to virus, RNA splicing Indicus|evm.model.CM009497.1.254 P54282 CAC1A_RAT 100.000 0.466667 0.0542495 Cacna1a - Voltage-dependent P/Q-type calcium channel subunit alpha-1A - Rattus norvegicus (Rat) - Cacna1a gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P30288) (PubMed:1311418). They are however insensitive to dihydropyridines (DHP). Indicus|evm.model.CM009497.1.255 O00555 CAC1A_HUMAN 93.701 0.941149 0.861133 CACNA1A - Voltage-dependent P/Q-type calcium channel subunit alpha-1A - Homo sapiens (Human) - CACNA1A gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). Indicus|evm.model.CM009497.1.256 Q9BTL4 IER2_HUMAN 82.143 0.991031 1 IER2 - Immediate early response gene 2 protein - Homo sapiens (Human) - IER2 gene DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713). Indicus|evm.model.CM009497.1.257 O60499 STX10_HUMAN 86.220 0.992157 1.0241 STX10 - Syntaxin-10 - Homo sapiens (Human) - STX10 gene SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Indicus|evm.model.CM009497.1.258 Q96RE7 NACC1_HUMAN 84.774 0.996226 1.00569 NACC1 - Nucleus accumbens-associated protein 1 - Homo sapiens (Human) - NACC1 gene Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Indicus|evm.model.CM009497.1.259 Q9NXH9 TRM1_HUMAN 88.943 0.651113 1.43096 TRMT1 - tRNA (guanine(26)-N(2))-dimethyltransferase - Homo sapiens (Human) - TRMT1 gene Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Indicus|evm.model.CM009497.1.261 Q14938 NFIX_HUMAN 99.036 0.938776 0.878486 NFIX - Nuclear factor 1 X-type - Homo sapiens (Human) - NFIX gene Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Indicus|evm.model.CM009497.1.262 A1A4P4 G45IP_BOVIN 99.099 0.991031 1.0045 GADD45GIP1 - Growth arrest and DNA damage-inducible proteins-interacting protein 1 - Bos taurus (Bovine) - GADD45GIP1 gene Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. Indicus|evm.model.CM009497.1.263 A3KMV2 RD23A_BOVIN 99.725 0.994505 1.00552 RAD23A - UV excision repair protein RAD23 homolog A - Bos taurus (Bovine) - RAD23A gene Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). Indicus|evm.model.CM009497.1.264 P52193 CALR_BOVIN 100.000 0.995215 1.0024 CALR - Calreticulin precursor - Bos taurus (Bovine) - CALR gene Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). Indicus|evm.model.CM009497.1.265 Q5RFA2 SYFA_PONAB 94.685 0.996071 1.00197 FARSA - Phenylalanine--tRNA ligase alpha subunit - Pongo abelii (Sumatran orangutan) - FARSA gene cytoplasm, phenylalanine-tRNA ligase complex, phenylalanine-tRNA ligase activity, phenylalanyl-tRNA aminoacylation, protein heterotetramerization Indicus|evm.model.CM009497.1.266 Q6PIF2 SYCE2_HUMAN 81.646 0.98125 0.733945 SYCE2 - Synaptonemal complex central element protein 2 - Homo sapiens (Human) - SYCE2 gene Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity). Indicus|evm.model.CM009497.1.267 Q2KHZ9 GCDH_BOVIN 99.772 0.995444 1.00228 GCDH - Glutaryl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - GCDH gene Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor (By similarity). Indicus|evm.model.CM009497.1.268 Q60793 KLF4_MOUSE 83.673 0.260054 0.772257 Klf4 - Krueppel-like factor 4 - Mus musculus (Mouse) - Klf4 gene Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity). Indicus|evm.model.CM009497.1.269 P56541 DNS2A_BOVIN 99.452 0.994536 1.00274 DNASE2 - Deoxyribonuclease-2-alpha precursor - Bos taurus (Bovine) - DNASE2 gene Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells (By similarity). Indicus|evm.model.CM009497.1.270 Q9Y2H9 MAST1_HUMAN 92.508 0.969144 1.01146 MAST1 - Microtubule-associated serine/threonine-protein kinase 1 - Homo sapiens (Human) - MAST1 gene Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). Indicus|evm.model.CM009497.1.271 Q4TUC0 RTBDN_CANLF 62.176 0.926702 0.856502 RTBDN - Retbindin precursor - Canis lupus familiaris (Dog) - RTBDN gene Riboflavin-binding protein which might have a role in retinal flavin transport. Indicus|evm.model.CM009497.1.272 Q2TBT5 RNH2A_BOVIN 100.000 0.993333 1.00334 RNASEH2A - Ribonuclease H2 subunit A - Bos taurus (Bovine) - RNASEH2A gene Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Indicus|evm.model.CM009497.1.273 A0A1W2PP97 THSD8_HUMAN 77.586 0.982906 1.01739 THSD8 - Thrombospondin type-1 domain-containing protein 8 precursor - Homo sapiens (Human) - THSD8 gene Indicus|evm.model.CM009497.1.274 Q9BGI3 PRDX2_BOVIN 100.000 0.99 1.00503 PRDX2 - Peroxiredoxin-2 - Bos taurus (Bovine) - PRDX2 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Indicus|evm.model.CM009497.1.275 Q0VBZ5 JUNB_BOVIN 100.000 0.994253 1.00288 JUNB - Transcription factor jun-B - Bos taurus (Bovine) - JUNB gene Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3' (By similarity). Indicus|evm.model.CM009497.1.276 Q96ED9 HOOK2_HUMAN 90.821 0.997211 0.997218 HOOK2 - Protein Hook homolog 2 - Homo sapiens (Human) - HOOK2 gene Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Indicus|evm.model.CM009497.1.277 Q8NFU1 BEST2_HUMAN 84.961 0.996101 1.00786 BEST2 - Bestrophin-2 - Homo sapiens (Human) - BEST2 gene Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Indicus|evm.model.CM009497.1.278 O43681 GET3_HUMAN 100.000 0.994269 1.00287 GET3 - ATPase GET3 - Homo sapiens (Human) - GET3 gene ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. Indicus|evm.model.CM009497.1.279 Q9BQ61 TRIR_HUMAN 95.531 0.988889 1.02273 TRIR - Telomerase RNA component interacting RNase - Homo sapiens (Human) - TRIR gene Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335). Indicus|evm.model.CM009497.1.280 O14787 TNPO2_HUMAN 99.108 0.901822 1.10145 TNPO2 - Transportin-2 - Homo sapiens (Human) - TNPO2 gene Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Indicus|evm.model.CM009497.1.281 Q2T9T9 FBXW9_BOVIN 99.563 0.995643 1.00218 FBXW9 - F-box/WD repeat-containing protein 9 - Bos taurus (Bovine) - FBXW9 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009497.1.282 A0A1W2PPG7 GBG14_HUMAN 79.167 0.972603 1.05797 GNG14 - Putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 - Homo sapiens (Human) - GNG14 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009497.1.283 Q6EWQ6 DHYS_BOVIN 99.729 0.994595 1.00271 DHPS - Deoxyhypusine synthase - Bos taurus (Bovine) - DHPS gene Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. Indicus|evm.model.CM009497.1.284 Q9BRX9 WDR83_HUMAN 95.238 0.993671 1.00317 WDR83 - WD repeat domain-containing protein 83 - Homo sapiens (Human) - WDR83 gene Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. Indicus|evm.model.CM009497.1.285 Q6ZWX0 ASTER_MOUSE 100.000 0.980392 0.962264 Wdr83os - PAT complex subunit Asterix - Mus musculus (Mouse) - Wdr83os gene Component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. WDR83OS/Asterix associates with the first transmembrane domain (TMD1) of the nascent chain, independently of the N-glycosylation of the chain and irrespective of the amino acid sequence and transmembrane topology of TMD1. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which TMD1 binds. Indicus|evm.model.CM009497.1.286 Q29451 MA2B1_BOVIN 100.000 0.998 1.001 MAN2B1 - Lysosomal alpha-mannosidase precursor - Bos taurus (Bovine) - MAN2B1 gene Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Indicus|evm.model.CM009497.1.287 Q8N972 ZN709_HUMAN 63.167 0.996255 0.833073 ZNF709 - Zinc finger protein 709 - Homo sapiens (Human) - ZNF709 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.290 Q8TBZ8 ZN564_HUMAN 54.007 0.740933 0.698011 ZNF564 - Zinc finger protein 564 - Homo sapiens (Human) - ZNF564 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.292 Q3ZCI9 TCPQ_BOVIN 97.445 0.996337 0.99635 CCT8 - T-complex protein 1 subunit theta - Bos taurus (Bovine) - CCT8 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.CM009497.1.293 Q96PQ6 ZN317_HUMAN 86.644 0.959872 1.04706 ZNF317 - Zinc finger protein 317 - Homo sapiens (Human) - ZNF317 gene May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation. Indicus|evm.model.CM009497.1.294 Q32PG5 SCND1_BOVIN 63.889 0.5 0.797753 SCAND1 - SCAN domain-containing protein 1 - Bos taurus (Bovine) - SCAND1 gene May regulate transcriptional activity. Indicus|evm.model.CM009497.1.295 Q32M78 ZN699_HUMAN 84.112 0.996694 0.942368 ZNF699 - Zinc finger protein 699 - Homo sapiens (Human) - ZNF699 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.296 Q13360 ZN177_HUMAN 70.713 0.875639 1.22037 ZNF177 - Zinc finger protein 177 - Homo sapiens (Human) - ZNF177 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.297 Q96MR9 ZN560_HUMAN 60.417 0.683453 0.175949 ZNF560 - Zinc finger protein 560 - Homo sapiens (Human) - ZNF560 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.298 Q96GC6 ZN274_HUMAN 54.545 0.353333 0.229709 ZNF274 - Neurotrophin receptor-interacting factor homolog - Homo sapiens (Human) - ZNF274 gene Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Indicus|evm.model.CM009497.1.299 Q32PG9 FXL12_BOVIN 100.000 0.993884 1.00307 FBXL12 - F-box/LRR-repeat protein 12 - Bos taurus (Bovine) - FBXL12 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity). Indicus|evm.model.CM009497.1.300 Q791B0 UBL5_PSAOB 100.000 0.94 0.684932 UBL5 - Ubiquitin-like protein 5 - Psammomys obesus (Fat sand rat) - UBL5 gene Indicus|evm.model.CM009497.1.301 Q5BIN5 PIN1_BOVIN 100.000 0.987805 1.00613 PIN1 - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 - Bos taurus (Bovine) - PIN1 gene Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner. Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN. May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells. Indicus|evm.model.CM009497.1.302 Q568Y7 NOE2_RAT 98.845 0.89441 1.01046 Olfm2 - Noelin-2 precursor - Rattus norvegicus (Rat) - Olfm2 gene Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (PubMed:28062493). Indicus|evm.model.CM009497.1.304 Q811Q4 ADA29_MOUSE 46.610 0.513274 0.296199 Adam29 - Disintegrin and metalloproteinase domain-containing protein 29 precursor - Mus musculus (Mouse) - Adam29 gene May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein (By similarity). Indicus|evm.model.CM009497.1.305 P01820 HVM44_MOUSE 75.000 0.0893536 4.57391 Ig heavy chain V region PJ14 precursor - Mus musculus (Mouse) Indicus|evm.model.CM009497.1.306 Q568Y7 NOE2_RAT 95.556 0.357724 0.257322 Olfm2 - Noelin-2 precursor - Rattus norvegicus (Rat) - Olfm2 gene Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (PubMed:28062493). Indicus|evm.model.CM009497.1.307 P25940 CO5A3_HUMAN 85.404 0.998845 0.99255 COL5A3 - Collagen alpha-3(V) chain precursor - Homo sapiens (Human) - COL5A3 gene Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Indicus|evm.model.CM009497.1.308 Q9N126 RDH8_BOVIN 99.359 0.99361 1.00321 RDH8 - Retinol dehydrogenase 8 - Bos taurus (Bovine) - RDH8 gene Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. Indicus|evm.model.CM009497.1.310 Q32L09 SHFL_BOVIN 100.000 0.993127 1.00345 SHFL - Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog - Bos taurus (Bovine) - SHFL gene Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (By similarity). May exhibit antiviral activity (By similarity). Indicus|evm.model.CM009497.1.311 Q8NI99 ANGL6_HUMAN 88.326 0.961538 0.995745 ANGPTL6 - Angiopoietin-related protein 6 precursor - Homo sapiens (Human) - ANGPTL6 gene May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure. Indicus|evm.model.CM009497.1.312 Q91YU8 SSF1_MOUSE 82.713 0.546218 1.77234 Ppan - Suppressor of SWI4 1 homolog - Mus musculus (Mouse) - Ppan gene May have a role in cell growth. Indicus|evm.model.CM009497.1.313 O75821 EIF3G_HUMAN 100.000 0.993769 1.00313 EIF3G - Eukaryotic translation initiation factor 3 subunit G - Homo sapiens (Human) - EIF3G gene RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. Indicus|evm.model.CM009497.1.314 Q24K09 DNMT1_BOVIN 100.000 0.978723 1.0211 DNMT1 - DNA (cytosine-5)-methyltransferase 1 - Bos taurus (Bovine) - DNMT1 gene Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth. Indicus|evm.model.CM009497.1.315 O95136 S1PR2_HUMAN 88.385 0.994334 1 S1PR2 - Sphingosine 1-phosphate receptor 2 - Homo sapiens (Human) - S1PR2 gene Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). Indicus|evm.model.CM009497.1.316 Q32PI6 RM04_BOVIN 100.000 0.99322 1.0034 MRPL4 - 39S ribosomal protein L4, mitochondrial - Bos taurus (Bovine) - MRPL4 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009497.1.317 Q95132 ICAM1_BOVIN 99.805 0.572228 1.66916 ICAM1 - Intercellular adhesion molecule 1 precursor - Bos taurus (Bovine) - ICAM1 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Indicus|evm.model.CM009497.1.318 Q9ERM2 ICAM4_MOUSE 70.161 0.925094 1.01908 Icam4 - Intercellular adhesion molecule 4 precursor - Mus musculus (Mouse) - Icam4 gene Adhesion molecule that binds to leukocyte adhesion LFA-1 protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins (By similarity). Isoform 2 may modulate binding of membrane-associated ICAM4. Indicus|evm.model.CM009497.1.319 Q9UMF0 ICAM5_HUMAN 88.420 0.997833 0.998918 ICAM5 - Intercellular adhesion molecule 5 precursor - Homo sapiens (Human) - ICAM5 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Indicus|evm.model.CM009497.1.320 P0C6A0 ZGLP1_HUMAN 68.333 0.835766 1.01107 ZGLP1 - GATA-type zinc finger protein 1 - Homo sapiens (Human) - ZGLP1 gene Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independently of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase. Indicus|evm.model.CM009497.1.321 Q05B51 FDX2_BOVIN 100.000 0.989305 1.00538 FDX2 - Ferredoxin-2, mitochondrial precursor - Bos taurus (Bovine) - FDX2 gene Essential for heme A and Fe/S protein biosynthesis. Indicus|evm.model.CM009497.1.322 Q8IY67 RAVR1_HUMAN 95.188 0.628458 1.25248 RAVER1 - Ribonucleoprotein PTB-binding 1 - Homo sapiens (Human) - RAVER1 gene Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). Indicus|evm.model.CM009497.1.323 Q28125 ICAM3_BOVIN 99.449 0.99633 1.00184 ICAM3 - Intercellular adhesion molecule 3 precursor - Bos taurus (Bovine) - ICAM3 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages. Indicus|evm.model.CM009497.1.324 P29597 TYK2_HUMAN 81.849 0.998305 0.994103 TYK2 - Non-receptor tyrosine-protein kinase TYK2 - Homo sapiens (Human) - TYK2 gene Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Indicus|evm.model.CM009497.1.325 Q5EAC6 CDC37_BOVIN 100.000 0.75463 0.568421 CDC37 - Hsp90 co-chaperone Cdc37 - Bos taurus (Bovine) - CDC37 gene Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity. Indicus|evm.model.CM009497.1.326 O89084 PDE4A_MOUSE 95.604 0.459184 0.232227 Pde4a - cAMP-specific 3',5'-cyclic phosphodiesterase 4A - Mus musculus (Mouse) - Pde4a gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Indicus|evm.model.CM009497.1.327 P27815 PDE4A_HUMAN 85.792 0.936528 0.871332 PDE4A - cAMP-specific 3',5'-cyclic phosphodiesterase 4A - Homo sapiens (Human) - PDE4A gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Indicus|evm.model.CM009497.1.328 Q684M4 KEAP1_PIG 99.038 0.9968 1.0016 KEAP1 - Kelch-like ECH-associated protein 1 - Sus scrofa (Pig) - KEAP1 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (By similarity). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity). Indicus|evm.model.CM009497.1.329 Q684M3 S1PR5_PIG 88.972 0.995 1.00503 S1PR5 - Sphingosine 1-phosphate receptor 5 - Sus scrofa (Pig) - S1PR5 gene Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins (By similarity). Indicus|evm.model.CM009497.1.330 Q684M2 ATG4D_PIG 94.503 0.995772 1.00853 ATG4D - Cysteine protease ATG4D - Sus scrofa (Pig) - ATG4D gene Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Indicus|evm.model.CM009497.1.331 Q0V8M0 KRI1_BOVIN 99.858 0.997167 1.00142 KRI1 - Protein KRI1 homolog - Bos taurus (Bovine) - KRI1 gene 90S preribosome, nucleolus, endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009497.1.332 Q29RV0 CDN2D_BOVIN 100.000 0.988024 1.00602 CDKN2D - Cyclin-dependent kinase 4 inhibitor D - Bos taurus (Bovine) - CDKN2D gene Interacts strongly with CDK4 and CDK6 and inhibits them. Indicus|evm.model.CM009497.1.333 Q3SYW1 AP1M2_BOVIN 99.764 0.995283 1.00236 AP1M2 - AP-1 complex subunit mu-2 - Bos taurus (Bovine) - AP1M2 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Indicus|evm.model.CM009497.1.334 A5D7H3 CTL2_BOVIN 99.713 0.987234 0.998584 SLC44A2 - Choline transporter-like protein 2 - Bos taurus (Bovine) - SLC44A2 gene Choline transporter. Indicus|evm.model.CM009497.1.335 Q12906 ILF3_HUMAN 96.000 0.997778 1.00671 ILF3 - Interleukin enhancer-binding factor 3 - Homo sapiens (Human) - ILF3 gene RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). Indicus|evm.model.CM009497.1.336 Q9BXR0 TGT_HUMAN 91.067 0.99505 1.00248 QTRT1 - Queuine tRNA-ribosyltransferase catalytic subunit 1 - Homo sapiens (Human) - QTRT1 gene Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). Indicus|evm.model.CM009497.1.337 A6H7I5 DYN2_BOVIN 100.000 0.365517 0.167436 DNM2 - Dynamin-2 - Bos taurus (Bovine) - DNM2 gene Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane. Indicus|evm.model.CM009497.1.338 A6H7I5 DYN2_BOVIN 99.877 0.996319 0.941109 DNM2 - Dynamin-2 - Bos taurus (Bovine) - DNM2 gene Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane. Indicus|evm.model.CM009497.1.339 Q2TBK5 TMED1_BOVIN 99.559 0.991228 1.00441 TMED1 - Transmembrane emp24 domain-containing protein 1 precursor - Bos taurus (Bovine) - TMED1 gene Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Indicus|evm.model.CM009497.1.340 Q86X55 CARM1_HUMAN 98.502 0.731139 1.19901 CARM1 - Histone-arginine methyltransferase CARM1 - Homo sapiens (Human) - CARM1 gene Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs. Indicus|evm.model.CM009497.1.341 Q9BWQ6 YIPF2_HUMAN 85.350 0.990385 0.987342 YIPF2 - Protein YIPF2 - Homo sapiens (Human) - YIPF2 gene Golgi apparatus, Golgi medial cisterna, Golgi trans cisterna, trans-Golgi network, transport vesicle Indicus|evm.model.CM009497.1.342 Q9BSF4 TIM29_HUMAN 85.769 0.941818 1.05769 TIMM29 - Mitochondrial import inner membrane translocase subunit Tim29 precursor - Homo sapiens (Human) - TIMM29 gene Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40. Indicus|evm.model.CM009497.1.343 P08642 RASH_CHICK 50.833 0.666667 0.904762 HRAS - GTPase HRas precursor - Gallus gallus (Chicken) - HRAS gene Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Indicus|evm.model.CM009497.1.345 Q6P9S1 ATMIN_MOUSE 76.923 0.195719 0.399756 Atmin - ATM interactor - Mus musculus (Mouse) - Atmin gene Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM (By similarity). Binds to the DYNLL1 promoter and activates its transcription. Indicus|evm.model.CM009497.1.346 A7Z019 SMCA4_BOVIN 100.000 0.998755 1.00062 SMARCA4 - Transcription activator BRG1 - Bos taurus (Bovine) - SMARCA4 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-fOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2. Binds to RNA in a promiscuous manner. Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities. Indicus|evm.model.CM009497.1.347 P01131 LDLR_BOVIN 99.408 0.997636 1.00118 LDLR - Low-density lipoprotein receptor precursor - Bos taurus (Bovine) - LDLR gene Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Indicus|evm.model.CM009497.1.348 Q24JY3 SPC24_BOVIN 96.517 0.990099 1.02538 SPC24 - Kinetochore protein Spc24 - Bos taurus (Bovine) - SPC24 gene Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Indicus|evm.model.CM009497.1.349 Q1LZH7 KANK2_BOVIN 98.261 0.901186 0.884615 KANK2 - KN motif and ankyrin repeat domain-containing protein 2 - Bos taurus (Bovine) - KANK2 gene Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (By similarity). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). Indicus|evm.model.CM009497.1.350 Q8VDR9 DOCK6_MOUSE 95.567 0.397646 0.735096 Dock6 - Dedicator of cytokinesis protein 6 - Mus musculus (Mouse) - Dock6 gene Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases (By similarity). Through its activation of CDC42 and RAC1, regulates neurite outgrowth in an vitro differentiation system. Indicus|evm.model.CM009497.1.351 Q6UXH0 ANGL8_HUMAN 69.192 0.98995 1.00505 ANGPTL8 - Angiopoietin-like protein 8 precursor - Homo sapiens (Human) - ANGPTL8 gene Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity). Indicus|evm.model.CM009497.1.352 Q96HP0 DOCK6_HUMAN 93.135 0.95053 0.276502 DOCK6 - Dedicator of cytokinesis protein 6 - Homo sapiens (Human) - DOCK6 gene Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). Indicus|evm.model.CM009497.1.353 Q9UKR8 TSN16_HUMAN 71.983 0.942857 1 TSPAN16 - Tetraspanin-16 - Homo sapiens (Human) - TSPAN16 gene integral component of membrane, integral component of plasma membrane Indicus|evm.model.CM009497.1.354 O95716 RAB3D_HUMAN 94.977 0.990909 1.00457 RAB3D - Ras-related protein Rab-3D - Homo sapiens (Human) - RAB3D gene Protein transport. Probably involved in regulated exocytosis (By similarity). Indicus|evm.model.CM009497.1.355 Q32L10 TM205_BOVIN 98.413 0.989474 1.00529 TMEM205 - Transmembrane protein 205 - Bos taurus (Bovine) - TMEM205 gene Indicus|evm.model.CM009497.1.356 P0C7I6 CC159_HUMAN 78.621 0.639381 1.52189 CCDC159 - Coiled-coil domain-containing protein 159 - Homo sapiens (Human) - CCDC159 gene Indicus|evm.model.CM009497.1.357 Q29RT8 PLPR2_BOVIN 98.645 0.812362 1.16452 PLPPR2 - Phospholipid phosphatase-related protein type 2 - Bos taurus (Bovine) - PLPPR2 gene integral component of plasma membrane, lipid phosphatase activity, phosphatidate phosphatase activity, phospholipid dephosphorylation, phospholipid metabolic process, signal transduction Indicus|evm.model.CM009497.1.358 Q6NVH7 SWAP1_HUMAN 81.498 0.900398 1.09607 SWSAP1 - ATPase SWSAP1 - Homo sapiens (Human) - SWSAP1 gene ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity. Indicus|evm.model.CM009497.1.359 Q9MYZ9 EPOR_PIG 86.444 0.996071 1 EPOR - Erythropoietin receptor precursor - Sus scrofa (Pig) - EPOR gene Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity). Indicus|evm.model.CM009497.1.360 Q3MIN7 RGL3_HUMAN 80.986 0.972527 1.02535 RGL3 - Ral guanine nucleotide dissociation stimulator-like 3 - Homo sapiens (Human) - RGL3 gene Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). Indicus|evm.model.CM009497.1.361 A7MBH5 ODAD3_BOVIN 99.839 0.996785 1.00161 ODAD3 - Outer dynein arm-docking complex subunit 3 - Bos taurus (Bovine) - ODAD3 gene Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules. Indicus|evm.model.CM009497.1.362 Q28034 GLU2B_BOVIN 100.000 0.852564 1.17073 PRKCSH - Glucosidase 2 subunit beta precursor - Bos taurus (Bovine) - PRKCSH gene Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). Indicus|evm.model.CM009497.1.363 Q14576 ELAV3_HUMAN 99.455 0.994565 1.00272 ELAVL3 - ELAV-like protein 3 - Homo sapiens (Human) - ELAVL3 gene RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity). Indicus|evm.model.CM009497.1.364 Q96CK0 ZN653_HUMAN 93.537 0.948304 1.0065 ZNF653 - Zinc finger protein 653 - Homo sapiens (Human) - ZNF653 gene Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity. Indicus|evm.model.CM009497.1.365 Q3SX05 ECSIT_BOVIN 99.538 0.995392 1.00231 ECSIT - Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor - Bos taurus (Bovine) - ECSIT gene Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). Indicus|evm.model.CM009497.1.366 Q2HJ38 CNN1_BOVIN 100.000 0.993289 1.00337 CNN1 - Calponin-1 - Bos taurus (Bovine) - CNN1 gene Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). Indicus|evm.model.CM009497.1.367 P09889 PPA5_PIG 88.496 0.971098 1.01765 ACP5 - Tartrate-resistant acid phosphatase type 5 precursor - Sus scrofa (Pig) - ACP5 gene Uteroferrin is a phosphoprotein phosphatase, synthesized in response to progesterone. It appears to function in transplacental transport of iron in pig. Indicus|evm.model.CM009497.1.368 Q2HJ60 ROA2_BOVIN 78.646 0.512064 1.09384 HNRNPA2B1 - Heterogeneous nuclear ribonucleoproteins A2/B1 - Bos taurus (Bovine) - HNRNPA2B1 gene Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity). Indicus|evm.model.CM009497.1.369 E9Q6I0 V2116_MOUSE 53.670 0.884058 0.241822 Vmn2r116 - Vomeronasal type-2 receptor 116 precursor - Mus musculus (Mouse) - Vmn2r116 gene Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation. Indicus|evm.model.CM009497.1.370 Q96NG5 ZN558_HUMAN 86.070 0.995037 1.00249 ZNF558 - Zinc finger protein 558 - Homo sapiens (Human) - ZNF558 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.371 Q6TAC4 V2R26_MOUSE 63.077 0.570796 0.264327 Vmn2r26 - Vomeronasal type-2 receptor 26 precursor - Mus musculus (Mouse) - Vmn2r26 gene Putative pheromone receptor. Indicus|evm.model.CM009497.1.372 Q6AYK1 RNPS1_RAT 70.476 0.390977 0.872131 Rnps1 - RNA-binding protein with serine-rich domain 1 - Rattus norvegicus (Rat) - Rnps1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity). Indicus|evm.model.CM009497.1.373 A6NE82 MB3L3_HUMAN 50.000 0.942408 0.918269 MBD3L3 - Putative methyl-CpG-binding domain protein 3-like 3 - Homo sapiens (Human) - MBD3L3 gene Indicus|evm.model.CM009497.1.374 P06213 INSR_HUMAN 96.237 0.998554 1.00072 INSR - Insulin receptor precursor - Homo sapiens (Human) - INSR gene Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). Indicus|evm.model.CM009497.1.375 Q6ZSZ5 ARHGI_HUMAN 76.979 0.955224 1.0338 ARHGEF18 - Rho guanine nucleotide exchange factor 18 - Homo sapiens (Human) - ARHGEF18 gene Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Indicus|evm.model.CM009497.1.376 Q96HA9 PX11C_HUMAN 82.427 0.987552 1 PEX11G - Peroxisomal membrane protein 11C - Homo sapiens (Human) - PEX11G gene Promotes membrane protrusion and elongation on the peroxisomal surface. Indicus|evm.model.CM009497.1.377 Q9NW07 ZN358_HUMAN 82.812 0.544834 1.80634 ZNF358 - Zinc finger protein 358 - Homo sapiens (Human) - ZNF358 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.378 Q9GZU1 MCLN1_HUMAN 93.276 0.996558 1.00172 MCOLN1 - Mucolipin-1 - Homo sapiens (Human) - MCOLN1 gene Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:15336987, PubMed:14749347, PubMed:29019983, PubMed:27623384). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:27787197, PubMed:25733853). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). Indicus|evm.model.CM009497.1.379 Q8IY17 PLPL6_HUMAN 93.575 0.990847 0.953455 PNPLA6 - Patatin-like phospholipase domain-containing protein 6 - Homo sapiens (Human) - PNPLA6 gene Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed:11927584). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed:11927584). Indicus|evm.model.CM009497.1.380 Q9P1Y5 CAMP3_HUMAN 88.020 0.979839 0.992794 CAMSAP3 - Calmodulin-regulated spectrin-associated protein 3 - Homo sapiens (Human) - CAMSAP3 gene Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). Indicus|evm.model.CM009497.1.381 Q9HCS7 SYF1_HUMAN 99.064 0.997664 1.00117 XAB2 - Pre-mRNA-splicing factor SYF1 - Homo sapiens (Human) - XAB2 gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804). Indicus|evm.model.CM009497.1.382 E1BHC3 PT100_BOVIN 100.000 0.974026 1.01316 PET100 - Protein PET100 homolog, mitochondrial precursor - Bos taurus (Bovine) - PET100 gene Plays a role in mitochondrial complex IV assembly. Indicus|evm.model.CM009497.1.383 P12660 PCP2_MOUSE 86.555 0.880597 1.11667 Pcp2 - Purkinje cell protein 2 - Mus musculus (Mouse) - Pcp2 gene May function as a cell-type specific modulator for G protein-mediated cell signaling. Indicus|evm.model.CM009497.1.384 Q15833 STXB2_HUMAN 95.110 0.996633 1.00169 STXBP2 - Syntaxin-binding protein 2 - Homo sapiens (Human) - STXBP2 gene Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. Indicus|evm.model.CM009497.1.385 Q762I5 RETN_BOVIN 99.083 0.981818 1.00917 RETN - Resistin precursor - Bos taurus (Bovine) - RETN gene Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes (By similarity). Indicus|evm.model.CM009497.1.387 Q8IUR0 TPPC5_HUMAN 99.468 0.989418 1.00532 TRAPPC5 - Trafficking protein particle complex subunit 5 - Homo sapiens (Human) - TRAPPC5 gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Indicus|evm.model.CM009497.1.388 P06734 FCER2_HUMAN 65.972 0.367609 1.21184 FCER2 - Low affinity immunoglobulin epsilon Fc receptor - Homo sapiens (Human) - FCER2 gene Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). Indicus|evm.model.CM009497.1.389 P20821 GCSH_BOVIN 89.394 0.180055 2.08671 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Indicus|evm.model.CM009497.1.390 Q8HY06 CLC4M_GORGO 48.344 0.565385 0.691489 CLEC4M - C-type lectin domain family 4 member M - Gorilla gorilla gorilla (Western lowland gorilla) - CLEC4M gene Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). Indicus|evm.model.CM009497.1.392 Q96CN4 EVI5L_HUMAN 98.241 0.997491 1.00378 EVI5L - EVI5-like protein - Homo sapiens (Human) - EVI5L gene Functions as a GTPase-activating protein (GAP) with a broad specificity. Indicus|evm.model.CM009497.1.393 Q9H6K5 PRR36_HUMAN 83.025 0.294602 0.812036 PRR36 - Proline-rich protein 36 - Homo sapiens (Human) - PRR36 gene Indicus|evm.model.CM009497.1.394 Q6NSJ5 LRC8E_HUMAN 92.588 0.997491 1.00126 LRRC8E - Volume-regulated anion channel subunit LRRC8E - Homo sapiens (Human) - LRRC8E gene Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:33139539). Indicus|evm.model.CM009497.1.395 O14733 MP2K7_HUMAN 99.469 0.532578 1.68496 MAP2K7 - Dual specificity mitogen-activated protein kinase kinase 7 - Homo sapiens (Human) - MAP2K7 gene Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). Indicus|evm.model.CM009497.1.396 Q13487 SNPC2_HUMAN 68.807 0.953216 1.02395 SNAPC2 - snRNA-activating protein complex subunit 2 - Homo sapiens (Human) - SNAPC2 gene Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. Indicus|evm.model.CM009497.1.397 P60606 CTXN1_HUMAN 100.000 0.975904 1.0122 CTXN1 - Cortexin-1 - Homo sapiens (Human) - CTXN1 gene May mediate extracellular or intracellular signaling of cortical neurons during forebrain development. Indicus|evm.model.CM009497.1.398 O43615 TIM44_HUMAN 90.989 0.995604 1.00664 TIMM44 - Mitochondrial import inner membrane translocase subunit TIM44 precursor - Homo sapiens (Human) - TIMM44 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). Indicus|evm.model.CM009497.1.399 Q15717 ELAV1_HUMAN 99.387 0.993884 1.00307 ELAVL1 - ELAV-like protein 1 - Homo sapiens (Human) - ELAVL1 gene RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). Indicus|evm.model.CM009497.1.400 Q4PR21 CCL25_PIG 69.737 0.986755 1 CCL25 - C-C motif chemokine 25 precursor - Sus scrofa (Pig) - CCL25 gene Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity). Indicus|evm.model.CM009497.1.401 Q75N90 FBN3_HUMAN 83.702 0.994056 1.01816 FBN3 - Fibrillin-3 precursor - Homo sapiens (Human) - FBN3 gene Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support. Indicus|evm.model.CM009497.1.402 Q5E9R6 CERS4_BOVIN 99.491 0.994924 1.00254 CERS4 - Ceramide synthase 4 - Bos taurus (Bovine) - CERS4 gene Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. Indicus|evm.model.CM009497.1.403 A6QNY1 CD320_BOVIN 100.000 0.992188 1.00392 CD320 - CD320 antigen precursor - Bos taurus (Bovine) - CD320 gene Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Indicus|evm.model.CM009497.1.404 Q05752 NDUA7_BOVIN 100.000 0.982456 1.00885 NDUFA7 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 - Bos taurus (Bovine) - NDUFA7 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009497.1.405 P62859 RS28_RAT 100.000 0.971429 1.01449 Rps28 - 40S ribosomal protein S28 - Rattus norvegicus (Rat) - Rps28 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, maturation of SSU-rRNA, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis Indicus|evm.model.CM009497.1.406 Q6NY19 KANK3_HUMAN 79.073 0.966625 0.963095 KANK3 - KN motif and ankyrin repeat domain-containing protein 3 - Homo sapiens (Human) - KANK3 gene May be involved in the control of cytoskeleton formation by regulating actin polymerization. Indicus|evm.model.CM009497.1.407 Q2KJ51 ANGL4_BOVIN 100.000 0.995134 1.00244 ANGPTL4 - Angiopoietin-related protein 4 precursor - Bos taurus (Bovine) - ANGPTL4 gene Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity). Indicus|evm.model.CM009497.1.408 O35509 RB11B_RAT 100.000 0.990868 1.00459 Rab11b - Ras-related protein Rab-11B precursor - Rattus norvegicus (Rat) - Rab11b gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Indicus|evm.model.CM009497.1.409 Q32L65 MARH2_BOVIN 100.000 0.779553 1.27755 MARCHF2 - E3 ubiquitin-protein ligase MARCHF2 - Bos taurus (Bovine) - MARCHF2 gene E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. Indicus|evm.model.CM009497.1.410 P52272 HNRPM_HUMAN 99.315 0.997264 1.00137 HNRNPM - Heterogeneous nuclear ribonucleoprotein M - Homo sapiens (Human) - HNRNPM gene Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. Indicus|evm.model.CM009497.1.411 Q32KV8 ZN414_BOVIN 91.445 0.336318 2.57033 ZNF414 - Zinc finger protein 414 - Bos taurus (Bovine) - ZNF414 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.412 O00160 MYO1F_HUMAN 95.173 0.99818 1.00091 MYO1F - Unconventional myosin-If - Homo sapiens (Human) - MYO1F gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Indicus|evm.model.CM009497.1.413 Q9H324 ATS10_HUMAN 95.917 0.945876 1.0553 ADAMTS10 - A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor - Homo sapiens (Human) - ADAMTS10 gene Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. Indicus|evm.model.CM009497.1.414 A0A5F9ZHS7 NFILZ_HUMAN 70.690 0.993007 0.989619 NFILZ - NFIL3 like protein - Homo sapiens (Human) - NFILZ gene Indicus|evm.model.CM009497.1.415 Q2T9W4 ACTL9_BOVIN 99.760 0.995204 1.0024 ACTL9 - Actin-like protein 9 - Bos taurus (Bovine) - ACTL9 gene dynactin complex Indicus|evm.model.CM009497.1.416 Q2HJ60 ROA2_BOVIN 78.571 0.65651 1.05865 HNRNPA2B1 - Heterogeneous nuclear ribonucleoproteins A2/B1 - Bos taurus (Bovine) - HNRNPA2B1 gene Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity). Indicus|evm.model.CM009497.1.417 Q86SQ3 AGRE4_HUMAN 74.031 0.951852 0.59081 ADGRE4P - Putative adhesion G protein-coupled receptor E4P precursor - Homo sapiens (Human) - ADGRE4P gene May mediate the cellular interaction between myeloid cells and B-cells. Indicus|evm.model.CM009497.1.418 O46415 FRIL_BOVIN 93.684 0.241026 2.22857 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009497.1.420 P51989 RO21_XENLA 73.206 0.589235 1.02023 Heterogeneous nuclear ribonucleoprotein A2 homolog 1 - Xenopus laevis (African clawed frog) Indicus|evm.model.CM009497.1.421 E9Q6I0 V2116_MOUSE 64.286 0.438395 0.40771 Vmn2r116 - Vomeronasal type-2 receptor 116 precursor - Mus musculus (Mouse) - Vmn2r116 gene Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation. Indicus|evm.model.CM009497.1.422 Q86SQ3 AGRE4_HUMAN 72.727 0.302652 1.40263 ADGRE4P - Putative adhesion G protein-coupled receptor E4P precursor - Homo sapiens (Human) - ADGRE4P gene May mediate the cellular interaction between myeloid cells and B-cells. Indicus|evm.model.CM009497.1.423 Q86SQ3 AGRE4_HUMAN 81.308 0.48855 1.43326 ADGRE4P - Putative adhesion G protein-coupled receptor E4P precursor - Homo sapiens (Human) - ADGRE4P gene May mediate the cellular interaction between myeloid cells and B-cells. Indicus|evm.model.CM009497.1.424 Q14246 AGRE1_HUMAN 67.328 0.652278 1.41196 ADGRE1 - Adhesion G protein-coupled receptor E1 precursor - Homo sapiens (Human) - ADGRE1 gene Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development. Indicus|evm.model.CM009497.1.425 Q08DN7 VAV_BOVIN 96.981 0.925532 0.334123 VAV1 - Proto-oncogene vav - Bos taurus (Bovine) - VAV1 gene Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Indicus|evm.model.CM009497.1.426 P54100 VAV_RAT 100.000 0.52381 0.149466 Vav1 - Proto-oncogene vav - Rattus norvegicus (Rat) - Vav1 gene Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Indicus|evm.model.CM009497.1.427 Q08DN7 VAV_BOVIN 100.000 0.841102 0.559242 VAV1 - Proto-oncogene vav - Bos taurus (Bovine) - VAV1 gene Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Indicus|evm.model.CM009497.1.428 Q5RCJ1 CIP4_PONAB 91.071 0.341076 1.36106 TRIP10 - Cdc42-interacting protein 4 - Pongo abelii (Sumatran orangutan) - TRIP10 gene Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Also acts as a link between CDC42 signaling and regulation of the actin cytoskeleton. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization in the vicinity of membrane tubules by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization and dynamin may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. May be required for the lysosomal retention of FASLG/FASL (By similarity). Indicus|evm.model.CM009497.1.429 Q148L1 GP108_BOVIN 99.474 0.530899 1.29927 GPR108 - Protein GPR108 precursor - Bos taurus (Bovine) - GPR108 gene cis-Golgi network membrane, Golgi apparatus, membrane, negative regulation of toll-like receptor signaling pathway, regulation of immune response Indicus|evm.model.CM009497.1.430 Q2UVX4 CO3_BOVIN 96.167 0.998804 1.00662 C3 - Complement C3 precursor - Bos taurus (Bovine) - C3 gene C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (By similarity). Indicus|evm.model.CM009497.1.431 O43557 TNF14_HUMAN 69.835 0.991736 1.00833 TNFSF14 - Tumor necrosis factor ligand superfamily member 14 - Homo sapiens (Human) - TNFSF14 gene Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:9462508, PubMed:10754304). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304). Indicus|evm.model.CM009497.1.432 Q3ZDR4 CD70_PIG 72.917 0.935644 1.06316 CD70 - CD70 antigen - Sus scrofa (Pig) - CD70 gene Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Indicus|evm.model.CM009497.1.433 P41273 TNFL9_HUMAN 49.804 0.972332 0.996063 TNFSF9 - Tumor necrosis factor ligand superfamily member 9 - Homo sapiens (Human) - TNFSF9 gene Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Indicus|evm.model.CM009497.1.434 Q9D6F9 TBB4A_MOUSE 100.000 0.560051 1.78153 Tubb4a - Tubulin beta-4A chain - Mus musculus (Mouse) - Tubb4a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009497.1.435 Q8IV53 DEN1C_HUMAN 78.589 0.997497 0.997503 DENND1C - DENN domain-containing protein 1C - Homo sapiens (Human) - DENND1C gene Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Indicus|evm.model.CM009497.1.436 A0A5F4BST2 CRUM3_CANLF 76.190 0.827869 0.99187 CRB3 - Protein crumbs homolog 3 precursor - Canis lupus familiaris (Dog) - CRB3 gene Involved in the establishment of cell polarity in mammalian epithelial cells (By similarity). Regulates the morphogenesis of tight junctions (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). Indicus|evm.model.CM009497.1.437 Q9BV35 SCMC3_HUMAN 86.029 0.936869 0.846154 SLC25A23 - Calcium-binding mitochondrial carrier protein SCaMC-3 - Homo sapiens (Human) - SLC25A23 gene Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (PubMed:15123600). May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (PubMed:15123600). Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1 (PubMed:24430870). Indicus|evm.model.CM009497.1.438 Q0II44 S2541_BOVIN 100.000 0.837838 1.06017 SLC25A41 - Mitochondrial carrier protein SCaMC-3L - Bos taurus (Bovine) - SLC25A41 gene Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane. Indicus|evm.model.CM009497.1.439 Q92945 FUBP2_HUMAN 98.493 0.990654 0.752461 KHSRP - Far upstream element-binding protein 2 - Homo sapiens (Human) - KHSRP gene Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. Indicus|evm.model.CM009497.1.440 Q5EA53 T2FA_BOVIN 100.000 0.996139 1.00193 GTF2F1 - General transcription factor IIF subunit 1 - Bos taurus (Bovine) - GTF2F1 gene TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity). Indicus|evm.model.CM009497.1.441 O60542 PSPN_HUMAN 77.344 0.792208 0.987179 PSPN - Persephin precursor - Homo sapiens (Human) - PSPN gene Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Indicus|evm.model.CM009497.1.442 Q2M2S8 ALKB7_BOVIN 100.000 0.990991 1.00452 ALKBH7 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial precursor - Bos taurus (Bovine) - ALKBH7 gene May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity (By similarity). Involved in fatty acid metabolism (By similarity). Indicus|evm.model.CM009497.1.443 Q2KHU4 CLPP_BOVIN 100.000 0.992674 1.00368 CLPP - ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor - Bos taurus (Bovine) - CLPP gene Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. Indicus|evm.model.CM009497.1.444 Q8TDN7 ACER1_HUMAN 77.273 0.992453 1.00379 ACER1 - Alkaline ceramidase 1 - Homo sapiens (Human) - ACER1 gene Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:17713573, PubMed:20207939, PubMed:20628055). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875). Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:17713573, PubMed:20207939). May also hydrolyze dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:17713573). Indicus|evm.model.CM009497.1.445 Q03111 ENL_HUMAN 91.367 0.93086 1.06082 MLLT1 - Protein ENL - Homo sapiens (Human) - MLLT1 gene Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). Indicus|evm.model.CM009497.1.447 Q5FVE4 ACBG2_HUMAN 71.982 0.986745 1.01952 ACSBG2 - Long-chain-fatty-acid--CoA ligase ACSBG2 - Homo sapiens (Human) - ACSBG2 gene Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:16371355, PubMed:16762313). Has increased ability to activate oleic and linoleic acid (PubMed:16371355). May play a role in spermatogenesis (PubMed:15685348). Indicus|evm.model.CM009497.1.448 A6QLW9 RFX2_BOVIN 100.000 0.912467 1.06648 RFX2 - DNA-binding protein RFX2 - Bos taurus (Bovine) - RFX2 gene Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6. Indicus|evm.model.CM009497.1.449 Q4R4T9 RANB3_MACFA 93.103 0.04811 1.16633 RANBP3 - Ran-binding protein 3 - Macaca fascicularis (Crab-eating macaque) - RANBP3 gene Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity). Indicus|evm.model.CM009497.1.450 Q0VCC0 CAYP1_BOVIN 100.000 0.989474 1.00529 CAPS - Calcyphosin - Bos taurus (Bovine) - CAPS gene Calcium-binding protein. May play a role in cellular signaling events (Potential). Indicus|evm.model.CM009497.1.451 A7YWC8 VMAC_BOVIN 99.398 0.988024 1.00602 VMAC - Vimentin-type intermediate filament-associated coiled-coil protein - Bos taurus (Bovine) - VMAC gene type III intermediate filament Indicus|evm.model.CM009497.1.452 Q8HXG6 NDUAB_BOVIN 100.000 0.985915 1.00709 NDUFA11 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 - Bos taurus (Bovine) - NDUFA11 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009497.1.453 Q11126 FUT3_BOVIN 99.349 0.993506 0.843836 FUT3 - 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 - Bos taurus (Bovine) - FUT3 gene Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens. Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration. Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin. Prefers type 1 chain over type 2 acceptors. Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred. Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Indicus|evm.model.CM009497.1.454 Q99748 NRTN_HUMAN 93.909 0.989899 1.00508 NRTN - Neurturin precursor - Homo sapiens (Human) - NRTN gene Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Indicus|evm.model.CM009497.1.455 Q96G46 DUS3L_HUMAN 85.474 0.996928 1.00154 DUS3L - tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like - Homo sapiens (Human) - DUS3L gene Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Indicus|evm.model.CM009497.1.456 Q8IZ63 PRR22_HUMAN 67.426 0.99536 1.02133 PRR22 - Proline-rich protein 22 - Homo sapiens (Human) - PRR22 gene Indicus|evm.model.CM009497.1.457 E1B9E5 CTSRD_BOVIN 99.868 0.977979 0.988476 CATSPERD - Cation channel sperm-associated protein subunit delta precursor - Bos taurus (Bovine) - CATSPERD gene Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane. Indicus|evm.model.CM009497.1.458 Q59HJ6 LONM_BOVIN 99.896 0.997921 1.00104 LONP1 - Lon protease homolog, mitochondrial precursor - Bos taurus (Bovine) - LONP1 gene ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (By similarity). Endogenous substrates include oxidized aconitase. Indicus|evm.model.CM009497.1.459 Q3T171 RL36_BOVIN 100.000 0.981132 1.00952 RPL36 - 60S ribosomal protein L36 - Bos taurus (Bovine) - RPL36 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009497.1.460 Q6Q7D1 DHI1L_BOVIN 100.000 0.993056 1.00348 HSD11B1L - Hydroxysteroid 11-beta-dehydrogenase 1-like protein precursor - Bos taurus (Bovine) - HSD11B1L gene Indicus|evm.model.CM009497.1.461 A1XQR7 MIC13_PIG 88.136 0.983193 1.00847 MICOS13 - MICOS complex subunit MIC13 - Sus scrofa (Pig) - MICOS13 gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex. Indicus|evm.model.CM009497.1.462 Q5R452 SAFB1_PONAB 93.370 0.109957 1.79103 SAFB - Scaffold attachment factor B1 - Pongo abelii (Sumatran orangutan) - SAFB gene Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (By similarity). Thereby acts as a negative regulator of cell proliferation (By similarity). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Indicus|evm.model.CM009497.1.463 Q14151 SAFB2_HUMAN 84.722 0.925595 1.05771 SAFB2 - Scaffold attachment factor B2 - Homo sapiens (Human) - SAFB2 gene Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. Indicus|evm.model.CM009497.1.464 Q4R6Y5 ZNRF4_MACFA 70.588 0.988889 0.839161 ZNRF4 - E3 ubiquitin-protein ligase ZNRF4 precursor - Macaca fascicularis (Crab-eating macaque) - ZNRF4 gene E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum. Could have a role in spermatogenesis. Indicus|evm.model.CM009497.1.465 Q64605 PTPRS_RAT 92.528 0.416112 0.787625 Ptprs - Receptor-type tyrosine-protein phosphatase S precursor - Rattus norvegicus (Rat) - Ptprs gene Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (By similarity). Functions as tyrosine phosphatase (PubMed:8068021). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (By similarity). Indicus|evm.model.CM009497.1.466 O94953 KDM4B_HUMAN 84.303 0.998209 1.01916 KDM4B - Lysine-specific demethylase 4B - Homo sapiens (Human) - KDM4B gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Indicus|evm.model.CM009497.1.468 A7E320 UHRF1_BOVIN 100.000 0.997459 1.00127 UHRF1 - E3 ubiquitin-protein ligase UHRF1 - Bos taurus (Bovine) - UHRF1 gene Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair (By similarity). Indicus|evm.model.CM009497.1.469 Q32KX1 ARRD5_BOVIN 99.398 0.924581 1.07831 ARRDC5 - Arrestin domain-containing protein 5 - Bos taurus (Bovine) - ARRDC5 gene Indicus|evm.model.CM009497.1.470 Q5BLZ2 PLIN3_PIG 89.522 0.995444 1 PLIN3 - Perilipin-3 - Sus scrofa (Pig) - PLIN3 gene Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network. Indicus|evm.model.CM009497.1.471 Q4JF29 TCAM1_BOVIN 98.113 0.826923 1.09618 TICAM1 - TIR domain-containing adapter molecule 1 - Bos taurus (Bovine) - TICAM1 gene Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity). Indicus|evm.model.CM009497.1.472 Q29RM5 FEM1A_BOVIN 100.000 0.996942 1.00153 FEM1A - Protein fem-1 homolog A - Bos taurus (Bovine) - FEM1A gene Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4 (By similarity). Indicus|evm.model.CM009497.1.474 Q86TI2 DPP9_HUMAN 92.451 0.96347 1.01506 DPP9 - Dipeptidyl peptidase 9 - Homo sapiens (Human) - DPP9 gene Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:30291141, PubMed:29382749). Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:30291141, PubMed:29967349, PubMed:31525884, PubMed:32796818). Indicus|evm.model.CM009497.1.475 P62248 MYDGF_BOVIN 100.000 0.988571 1.00575 MYDGF - Myeloid-derived growth factor precursor - Bos taurus (Bovine) - MYDGF gene Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway. Indicus|evm.model.CM009497.1.476 A5PK29 TP8L1_BOVIN 100.000 0.989305 1.00538 TNFAIP8L1 - Tumor necrosis factor alpha-induced protein 8-like protein 1 - Bos taurus (Bovine) - TNFAIP8L1 gene Acts as a negative regulator of mTOR activity. Indicus|evm.model.CM009497.1.477 Q9H3T3 SEM6B_HUMAN 94.656 0.976119 0.754505 SEMA6B - Semaphorin-6B precursor - Homo sapiens (Human) - SEMA6B gene Functions as a cell surface repellent for mossy fibers of developping neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. Indicus|evm.model.CM009497.1.478 P02750 A2GL_HUMAN 69.741 0.974576 1.02017 LRG1 - Leucine-rich alpha-2-glycoprotein precursor - Homo sapiens (Human) - LRG1 gene extracellular exosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, intracellular membrane-bounded organelle, membrane, specific granule lumen, tertiary granule lumen, neutrophil degranulation Indicus|evm.model.CM009497.1.479 A6QLL0 PLIN5_BOVIN 99.781 0.995624 1.00219 PLIN5 - Perilipin-5 - Bos taurus (Bovine) - PLIN5 gene Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). Indicus|evm.model.CM009497.1.480 Q96Q06 PLIN4_HUMAN 62.270 0.985145 0.94252 PLIN4 - Perilipin-4 - Homo sapiens (Human) - PLIN4 gene May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity). Indicus|evm.model.CM009497.1.481 Q7Z4V5 HDGR2_HUMAN 85.630 0.994065 1.00447 HDGFL2 - Hepatoma-derived growth factor-related protein 2 - Homo sapiens (Human) - HDGFL2 gene Involved in cellular growth control, through the regulation of cyclin D1 expression. Indicus|evm.model.CM009497.1.482 Q2KIJ6 UBXN6_BOVIN 99.320 0.995475 1.00227 UBXN6 - UBX domain-containing protein 6 - Bos taurus (Bovine) - UBXN6 gene May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Indicus|evm.model.CM009497.1.483 A6QLA6 CAF1A_BOVIN 99.896 0.927746 1.07676 CHAF1A - Chromatin assembly factor 1 subunit A - Bos taurus (Bovine) - CHAF1A gene Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. Indicus|evm.model.CM009497.1.484 Q2KJA1 SH3G1_BOVIN 100.000 0.99458 1.00272 SH3GL1 - Endophilin-A2 - Bos taurus (Bovine) - SH3GL1 gene Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Indicus|evm.model.CM009497.1.485 Q3TV65 MPND_MOUSE 85.287 0.882114 1.01027 Mpnd - MPN domain-containing protein - Mus musculus (Mouse) - Mpnd gene Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (By similarity). Indicus|evm.model.CM009497.1.486 Q9UGK3 STAP2_HUMAN 75.366 0.995098 1.01241 STAP2 - Signal-transducing adaptor protein 2 - Homo sapiens (Human) - STAP2 gene Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. Indicus|evm.model.CM009497.1.487 Q05B84 FSD1_BOVIN 100.000 0.995976 1.00202 FSD1 - Fibronectin type III and SPRY domain-containing protein 1 - Bos taurus (Bovine) - FSD1 gene May be involved in microtubule organization and stabilization. Indicus|evm.model.CM009497.1.488 Q96BF3 TMIG2_HUMAN 54.545 0.918089 1.03901 TMIGD2 - Transmembrane and immunoglobulin domain-containing protein 2 precursor - Homo sapiens (Human) - TMIGD2 gene Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. Indicus|evm.model.CM009497.1.489 Q96IW2 SHD_HUMAN 89.736 0.994152 1.00588 SHD - SH2 domain-containing adapter protein D - Homo sapiens (Human) - SHD gene May function as an adapter protein. Indicus|evm.model.CM009497.1.490 Q9BW85 YJU2_HUMAN 84.520 0.993769 0.993808 YJU2 - Splicing factor YJU2 - Homo sapiens (Human) - YJU2 gene Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:29301961). Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453). Indicus|evm.model.CM009497.1.491 Q14213 IL27B_HUMAN 73.451 0.965665 1.01747 EBI3 - Interleukin-27 subunit beta precursor - Homo sapiens (Human) - EBI3 gene Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Indicus|evm.model.CM009497.1.492 Q8TF21 ANR24_HUMAN 75.913 0.959166 1.00436 ANKRD24 - Ankyrin repeat domain-containing protein 24 - Homo sapiens (Human) - ANKRD24 gene Indicus|evm.model.CM009497.1.493 Q8N6T7 SIR6_HUMAN 88.579 0.881773 1.14366 SIRT6 - NAD-dependent protein deacetylase sirtuin-6 - Homo sapiens (Human) - SIRT6 gene NAD-dependent protein deacetylase involved in various processes including telomere maintenance and gene expression, and consequently has roles in genomic stability, cell senescence and apoptosis (PubMed:18337721, PubMed:19135889, PubMed:19625767, PubMed:21362626). Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (PubMed:21362626). Has deacetylase activity towards histone H3K9Ac and H3K56Ac (PubMed:19625767, PubMed:21362626). Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle (PubMed:19625767). May also be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance (PubMed:18337721). Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes (PubMed:21362626). Deacetylation of nucleosomes interferes with RELA binding to target DNA (PubMed:19135889). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis (By similarity). Required for normal IGF1 serum levels and normal glucose homeostasis (By similarity). Regulates the production of TNF protein (By similarity). Has a role in the regulation of life span (By similarity). Indicus|evm.model.CM009497.1.494 Q3SYZ3 CR3L3_BOVIN 100.000 0.995624 1.00219 CREB3L3 - Cyclic AMP-responsive element-binding protein 3-like protein 3 - Bos taurus (Bovine) - CREB3L3 gene Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression (By similarity). Regulates FGF21 transcription (By similarity). Indicus|evm.model.CM009497.1.495 Q1HG70 MP2K2_CANLF 98.500 0.995012 1.0025 MAP2K2 - Dual specificity mitogen-activated protein kinase kinase 2 - Canis lupus familiaris (Dog) - MAP2K2 gene Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). Indicus|evm.model.CM009497.1.496 O95365 ZBT7A_HUMAN 96.154 0.989899 0.847603 ZBTB7A - Zinc finger and BTB domain-containing protein 7A - Homo sapiens (Human) - ZBTB7A gene Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149). Indicus|evm.model.CM009497.1.497 Q8N2W9 PIAS4_HUMAN 94.542 0.996109 1.00784 PIAS4 - E3 SUMO-protein ligase PIAS4 - Homo sapiens (Human) - PIAS4 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Indicus|evm.model.CM009497.1.498 P84246 H33_RABIT 98.529 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009497.1.499 Q3SYU2 EF2_BOVIN 100.000 0.997672 1.00117 EEF2 - Elongation factor 2 - Bos taurus (Bovine) - EEF2 gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Indicus|evm.model.CM009497.1.500 O43293 DAPK3_HUMAN 94.934 0.995604 1.0022 DAPK3 - Death-associated protein kinase 3 - Homo sapiens (Human) - DAPK3 gene Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. Indicus|evm.model.CM009497.1.501 Q9NPI5 NRK2_HUMAN 90.840 0.977444 0.578261 NMRK2 - Nicotinamide riboside kinase 2 - Homo sapiens (Human) - NMRK2 gene Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis. Indicus|evm.model.CM009497.1.502 Q86WG3 ATCAY_HUMAN 94.609 0.994624 1.0027 ATCAY - Caytaxin - Homo sapiens (Human) - ATCAY gene Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites. Indicus|evm.model.CM009497.1.503 Q9UPR6 ZFR2_HUMAN 62.653 0.990826 1.04473 ZFR2 - Zinc finger RNA-binding protein 2 - Homo sapiens (Human) - ZFR2 gene double-stranded RNA binding, single-stranded RNA binding Indicus|evm.model.CM009497.1.504 P42679 MATK_HUMAN 86.157 0.993363 0.891519 MATK - Megakaryocyte-associated tyrosine-protein kinase - Homo sapiens (Human) - MATK gene Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. Indicus|evm.model.CM009497.1.505 Q7YRX0 RAX2_BOVIN 100.000 0.989189 1.00543 RAX2 - Retina and anterior neural fold homeobox protein 2 - Bos taurus (Bovine) - RAX2 gene May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter (By similarity). Indicus|evm.model.CM009497.1.506 Q3MHJ5 RM54_BOVIN 98.551 0.985612 1.00725 MRPL54 - 39S ribosomal protein L54, mitochondrial precursor - Bos taurus (Bovine) - MRPL54 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009497.1.507 O96018 APBA3_HUMAN 83.045 0.996546 1.00696 APBA3 - Amyloid-beta A4 precursor protein-binding family A member 3 - Homo sapiens (Human) - APBA3 gene May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. Indicus|evm.model.CM009497.1.508 O95049 ZO3_HUMAN 84.766 0.997812 0.994559 TJP3 - Tight junction protein ZO-3 - Homo sapiens (Human) - TJP3 gene TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). Indicus|evm.model.CM009497.1.509 O60331 PI51C_HUMAN 94.188 0.997015 1.00299 PIP5K1C - Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma - Homo sapiens (Human) - PIP5K1C gene Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:12422219, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed:12847086). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:17261850). Participates in cell junction assembly (PubMed:17261850). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed:17261850). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed:12422219). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed:12422219). Required for uropodium formation and retraction of the cell rear during directed migration (By similarity). Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (By similarity). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity). Indicus|evm.model.CM009497.1.510 Q8WUQ7 CATIN_HUMAN 90.272 0.910172 0.998681 CACTIN - Cactin - Homo sapiens (Human) - CACTIN gene Involved in the regulation of innate immune response (PubMed:20829348). Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (PubMed:20829348, PubMed:26363554). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (PubMed:20829348, PubMed:26363554). Indicus|evm.model.CM009497.1.511 Q95125 TA2R_BOVIN 99.417 0.994186 1.00292 TBXA2R - Thromboxane A2 receptor - Bos taurus (Bovine) - TBXA2R gene Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase. Indicus|evm.model.CM009497.1.512 Q8TF64 GIPC3_HUMAN 92.982 0.982609 0.36859 GIPC3 - PDZ domain-containing protein GIPC3 - Homo sapiens (Human) - GIPC3 gene Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion. Indicus|evm.model.CM009497.1.513 Q32L68 HM20B_BOVIN 100.000 0.987013 0.485804 HMG20B - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related - Bos taurus (Bovine) - HMG20B gene Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity). Indicus|evm.model.CM009497.1.514 Q8R5M0 GIPC3_MOUSE 95.455 0.802752 0.734007 Gipc3 - PDZ domain-containing protein GIPC3 - Mus musculus (Mouse) - Gipc3 gene Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion. Indicus|evm.model.CM009497.1.515 Q32L68 HM20B_BOVIN 100.000 0.229412 2.14511 HMG20B - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related - Bos taurus (Bovine) - HMG20B gene Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity). Indicus|evm.model.CM009497.1.516 Q2M2T2 CS071_BOVIN 99.333 0.506803 1.41346 Uncharacterized protein C19orf71 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009497.1.517 Q9R1K5 FZR1_MOUSE 98.986 0.947977 1.05274 Fzr1 - Fizzy-related protein homolog - Mus musculus (Mouse) - Fzr1 gene Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). Indicus|evm.model.CM009497.1.519 Q0VC53 DOHH_BOVIN 99.340 0.993421 1.0033 DOHH - Deoxyhypusine hydroxylase - Bos taurus (Bovine) - DOHH gene Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. Indicus|evm.model.CM009497.1.521 Q0VG18 SIM24_MOUSE 78.182 0.385185 1.125 Smim24 - Small integral membrane protein 24 precursor - Mus musculus (Mouse) - Smim24 gene Indicus|evm.model.CM009497.1.523 P21999 NFIC_PIG 99.395 0.935728 1.04545 NFIC - Nuclear factor 1 C-type - Sus scrofa (Pig) - NFIC gene Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Indicus|evm.model.CM009497.1.524 Q8N6W0 CELF5_HUMAN 97.783 0.944056 0.884536 CELF5 - CUGBP Elav-like family member 5 - Homo sapiens (Human) - CELF5 gene RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Indicus|evm.model.CM009497.1.525 Q969V3 NCLN_HUMAN 94.139 0.996441 0.998224 NCLN - Nicalin precursor - Homo sapiens (Human) - NCLN gene Component of a ribosome-associated translocon complex involved in multi-pass membrane protein transport into the endoplasmic reticulum (ER) membrane and biogenesis (PubMed:32820719). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity). Indicus|evm.model.CM009497.1.526 O95977 S1PR4_HUMAN 85.714 0.994819 1.00521 S1PR4 - Sphingosine 1-phosphate receptor 4 - Homo sapiens (Human) - S1PR4 gene Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. Indicus|evm.model.CM009497.1.527 P30679 GNA15_HUMAN 92.513 0.994667 1.00267 GNA15 - Guanine nucleotide-binding protein subunit alpha-15 - Homo sapiens (Human) - GNA15 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Indicus|evm.model.CM009497.1.528 P38409 GNA11_BOVIN 99.054 0.710112 1.23955 GNA11 - Guanine nucleotide-binding protein subunit alpha-11 - Bos taurus (Bovine) - GNA11 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Indicus|evm.model.CM009497.1.529 Q08117 TLE5_HUMAN 100.000 0.984211 0.964467 TLE5 - TLE family member 5 - Homo sapiens (Human) - TLE5 gene Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. Indicus|evm.model.CM009497.1.530 Q04725 TLE2_HUMAN 95.733 0.875312 1.07941 TLE2 - Transducin-like enhancer protein 2 - Homo sapiens (Human) - TLE2 gene Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). Indicus|evm.model.CM009497.1.531 Q9H808 TLE6_HUMAN 55.732 0.982639 1.00699 TLE6 - Transducin-like enhancer protein 6 - Homo sapiens (Human) - TLE6 gene Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (By similarity). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (By similarity). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (By similarity). Indicus|evm.model.CM009497.1.532 Q15935 ZNF77_HUMAN 54.910 0.993603 0.86055 ZNF77 - Zinc finger protein 77 - Homo sapiens (Human) - ZNF77 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.533 Q15935 ZNF77_HUMAN 53.232 0.993915 0.904587 ZNF77 - Zinc finger protein 77 - Homo sapiens (Human) - ZNF77 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.534 Q8NEP9 ZN555_HUMAN 86.667 0.988615 0.839172 ZNF555 - Zinc finger protein 555 - Homo sapiens (Human) - ZNF555 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.535 Q7L945 ZN627_HUMAN 88.372 0.3 0.303688 ZNF627 - Zinc finger protein 627 - Homo sapiens (Human) - ZNF627 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.536 Q86TJ5 ZN554_HUMAN 70.842 0.993852 0.907063 ZNF554 - Zinc finger protein 554 - Homo sapiens (Human) - ZNF554 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.537 Q1JPJ8 THOP1_BOVIN 99.854 0.997093 1.00146 THOP1 - Thimet oligopeptidase - Bos taurus (Bovine) - THOP1 gene Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity). Indicus|evm.model.CM009497.1.538 Q32LM2 SGTA_BOVIN 100.000 0.832 1.19808 SGTA - Small glutamine-rich tetratricopeptide repeat-containing protein alpha - Bos taurus (Bovine) - SGTA gene Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity. Indicus|evm.model.CM009497.1.539 Q5E960 S39A3_BOVIN 100.000 0.993651 1.00318 SLC39A3 - Zinc transporter ZIP3 - Bos taurus (Bovine) - SLC39A3 gene Acts as a zinc-influx transporter. Indicus|evm.model.CM009497.1.540 O95057 DIRA1_HUMAN 98.485 0.98995 1.00505 DIRAS1 - GTP-binding protein Di-Ras1 precursor - Homo sapiens (Human) - DIRAS1 gene Displays low GTPase activity and exists predominantly in the GTP-bound form. Indicus|evm.model.CM009497.1.542 P30671 GBG7_BOVIN 100.000 0.971014 1.01471 GNG7 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 precursor - Bos taurus (Bovine) - GNG7 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity). Indicus|evm.model.CM009497.1.543 Q5E9A5 GA45B_BOVIN 100.000 0.987578 1.00625 GADD45B - Growth arrest and DNA damage-inducible protein GADD45 beta - Bos taurus (Bovine) - GADD45B gene Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity). Indicus|evm.model.CM009497.1.544 Q03252 LMNB2_HUMAN 86.943 0.99682 1.01452 LMNB2 - Lamin-B2 precursor - Homo sapiens (Human) - LMNB2 gene Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Indicus|evm.model.CM009497.1.545 Q9Y5L4 TIM13_HUMAN 98.947 0.979167 1.01053 TIMM13 - Mitochondrial import inner membrane translocase subunit Tim13 - Homo sapiens (Human) - TIMM13 gene Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Indicus|evm.model.CM009497.1.546 Q7Z410 TMPS9_HUMAN 80.365 0.998175 1.03494 TMPRSS9 - Transmembrane protease serine 9 - Homo sapiens (Human) - TMPRSS9 gene Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed. Indicus|evm.model.CM009497.1.547 Q8TCT7 SPP2B_HUMAN 83.513 0.953767 0.986486 SPPL2B - Signal peptide peptidase-like 2B precursor - Homo sapiens (Human) - SPPL2B gene Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). Indicus|evm.model.CM009497.1.548 Q9UK45 LSM7_HUMAN 100.000 0.980769 1.00971 LSM7 - U6 snRNA-associated Sm-like protein LSm7 - Homo sapiens (Human) - LSM7 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Indicus|evm.model.CM009497.1.550 P0C6S8 LIGO3_HUMAN 93.243 0.996627 1.00169 LINGO3 - Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 precursor - Homo sapiens (Human) - LINGO3 gene extracellular matrix, extracellular space Indicus|evm.model.CM009497.1.551 Q6ZS72 PEAK3_HUMAN 68.277 0.995717 0.987315 PEAK3 - Protein PEAK3 - Homo sapiens (Human) - PEAK3 gene Probable catalytically inactive kinase (Probable). Interacts with CRK-II and antagonizes CRK-II-signaling. Prevents the formation of CRK-II-dependent membrane ruffling and lamellipodia-like extensions (PubMed:31311869). Indicus|evm.model.CM009497.1.552 Q56K12 OAZ1_BOVIN 87.917 0.991561 1.04405 OAZ1 - Ornithine decarboxylase antizyme 1 - Bos taurus (Bovine) - OAZ1 gene Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Indicus|evm.model.CM009497.1.553 Q8TEK3 DOT1L_HUMAN 83.959 0.998687 0.990891 DOT1L - Histone-lysine N-methyltransferase, H3 lysine-79 specific - Homo sapiens (Human) - DOT1L gene Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). Indicus|evm.model.CM009497.1.554 Q3ZCI3 PKHJ1_BOVIN 100.000 0.986667 1.00671 PLEKHJ1 - Pleckstrin homology domain-containing family J member 1 - Bos taurus (Bovine) - PLEKHJ1 gene early endosome, recycling endosome, trans-Golgi network, endosome organization, receptor recycling, retrograde transport, endosome to Golgi Indicus|evm.model.CM009497.1.555 A5PJN8 SF3A2_BOVIN 100.000 0.910714 0.469602 SF3A2 - Splicing factor 3A subunit 2 - Bos taurus (Bovine) - SF3A2 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron. Indicus|evm.model.CM009497.1.556 P03972 MIS_BOVIN 99.652 0.996528 1.00174 AMH - Muellerian-inhibiting factor precursor - Bos taurus (Bovine) - AMH gene This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. Indicus|evm.model.CM009497.1.557 Q2YDF7 JSPR1_BOVIN 99.407 0.82963 1.20178 JSRP1 - Junctional sarcoplasmic reticulum protein 1 - Bos taurus (Bovine) - JSRP1 gene Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S (By similarity). EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. Indicus|evm.model.CM009497.1.558 Q865S1 AP3D1_BOVIN 99.917 0.998344 1.00083 AP3D1 - AP-3 complex subunit delta-1 - Bos taurus (Bovine) - AP3D1 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Indicus|evm.model.CM009497.1.559 Q4R6V5 IZUM4_MACFA 84.475 0.990654 0.977169 IZUMO4 - Izumo sperm-egg fusion protein 4 precursor - Macaca fascicularis (Crab-eating macaque) - IZUMO4 gene Indicus|evm.model.CM009497.1.560 Q58D63 MOB3A_BOVIN 100.000 0.990826 1.00461 MOB3A - MOB kinase activator 3A - Bos taurus (Bovine) - MOB3A gene May regulate the activity of kinases. Indicus|evm.model.CM009497.1.561 Q9HBH9 MKNK2_HUMAN 94.409 0.995699 1 MKNK2 - MAP kinase-interacting serine/threonine-protein kinase 2 - Homo sapiens (Human) - MKNK2 gene Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. Indicus|evm.model.CM009497.1.562 Q5RDM6 RAP1B_PONAB 98.913 0.989189 1.00543 RAP1B - Ras-related protein Rap-1b precursor - Pongo abelii (Sumatran orangutan) - RAP1B gene GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity). Indicus|evm.model.CM009497.1.563 Q0VCP4 SEPT8_BOVIN 99.525 0.789474 1.20362 SEPTIN8 - Septin-8 - Bos taurus (Bovine) - SEPTIN8 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (By similarity). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). Indicus|evm.model.CM009497.1.564 Q6ZMN8 CCNI2_HUMAN 53.333 0.776744 0.582656 CCNI2 - Cyclin-I2 - Homo sapiens (Human) - CCNI2 gene cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus, cyclin-dependent protein serine/threonine kinase regulator activity, mitotic cell cycle phase transition, regulation of cyclin-dependent protein serine/threonine kinase activity Indicus|evm.model.CM009497.1.565 Q9Y496 KIF3A_HUMAN 98.999 0.997143 1.00143 KIF3A - Kinesin-like protein KIF3A - Homo sapiens (Human) - KIF3A gene Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. Indicus|evm.model.CM009497.1.566 P30367 IL4_BOVIN 100.000 0.985294 1.00741 IL4 - Interleukin-4 precursor - Bos taurus (Bovine) - IL4 gene Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. Indicus|evm.model.CM009497.1.567 Q9XSV9 IL13_BOVIN 100.000 0.984962 1.00758 IL13 - Interleukin-13 precursor - Bos taurus (Bovine) - IL13 gene Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. Indicus|evm.model.CM009497.1.568 Q92878 RAD50_HUMAN 95.231 0.984091 1.0061 RAD50 - DNA repair protein RAD50 - Homo sapiens (Human) - RAD50 gene Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). Indicus|evm.model.CM009497.1.569 Q3SZP0 IRF1_BOVIN 99.689 0.993808 1.00311 IRF1 - Interferon regulatory factor 1 - Bos taurus (Bovine) - IRF1 gene Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (By similarity). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (By similarity). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Binds to a consensus sequence in gene promoters (By similarity). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (By similarity). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (By similarity). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (By similarity). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (By similarity). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (By similarity). Indicus|evm.model.CM009497.1.571 O76082 S22A5_HUMAN 90.305 0.996416 1.0018 SLC22A5 - Solute carrier family 22 member 5 - Homo sapiens (Human) - SLC22A5 gene Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. Indicus|evm.model.CM009497.1.572 Q9H015 S22A4_HUMAN 86.799 0.99639 1.00544 SLC22A4 - Solute carrier family 22 member 4 - Homo sapiens (Human) - SLC22A4 gene Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). Indicus|evm.model.CM009497.1.573 Q3T005 PDLI4_BOVIN 100.000 0.993976 1.00302 PDLIM4 - PDZ and LIM domain protein 4 - Bos taurus (Bovine) - PDLIM4 gene Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). Indicus|evm.model.CM009497.1.574 O15460 P4HA2_HUMAN 90.991 0.996403 1.03925 P4HA2 - Prolyl 4-hydroxylase subunit alpha-2 precursor - Homo sapiens (Human) - P4HA2 gene Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Indicus|evm.model.CM009497.1.575 P79103 RS4_BOVIN 98.479 0.992424 1.0038 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009497.1.578 P11052 CSF2_BOVIN 98.601 0.986111 1.00699 CSF2 - Granulocyte-macrophage colony-stimulating factor precursor - Bos taurus (Bovine) - CSF2 gene Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Indicus|evm.model.CM009497.1.579 P49875 IL3_BOVIN 99.306 0.986207 1.00694 IL3 - Interleukin-3 precursor - Bos taurus (Bovine) - IL3 gene Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Indicus|evm.model.CM009497.1.580 Q9UKU0 ACSL6_HUMAN 92.683 0.962656 1.0373 ACSL6 - Long-chain-fatty-acid--CoA ligase 6 - Homo sapiens (Human) - ACSL6 gene Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. Indicus|evm.model.CM009497.1.581 Q8TF40 FNIP1_HUMAN 93.843 0.761937 1.2753 FNIP1 - Folliculin-interacting protein 1 - Homo sapiens (Human) - FNIP1 gene Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases (PubMed:24081491). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Required for B-cell development (By similarity). Indicus|evm.model.CM009497.1.582 Q8TEU7 RPGF6_HUMAN 93.532 0.998751 1 RAPGEF6 - Rap guanine nucleotide exchange factor 6 - Homo sapiens (Human) - RAPGEF6 gene Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. Indicus|evm.model.CM009497.1.583 A6QLJ4 C42S2_BOVIN 100.000 0.976471 1.0119 CDC42SE2 - CDC42 small effector protein 2 - Bos taurus (Bovine) - CDC42SE2 gene Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity). Indicus|evm.model.CM009497.1.584 Q2M2S9 LYRM7_BOVIN 99.038 0.980952 1.00962 LYRM7 - Complex III assembly factor LYRM7 - Bos taurus (Bovine) - LYRM7 gene Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity). Indicus|evm.model.CM009497.1.585 P62958 HINT1_BOVIN 100.000 0.984252 1.00794 HINT1 - Histidine triad nucleotide-binding protein 1 - Bos taurus (Bovine) - HINT1 gene Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Indicus|evm.model.CM009497.1.586 Q70JA7 CHSS3_HUMAN 95.000 0.996161 0.590703 CHSY3 - Chondroitin sulfate synthase 3 - Homo sapiens (Human) - CHSY3 gene Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. Indicus|evm.model.CM009497.1.587 Q70JA7 CHSS3_HUMAN 92.683 0.99187 0.418367 CHSY3 - Chondroitin sulfate synthase 3 - Homo sapiens (Human) - CHSY3 gene Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. Indicus|evm.model.CM009497.1.588 P59773 MNARL_HUMAN 84.127 0.984293 1.00526 MINAR2 - Major intrinsically disordered NOTCH2-binding receptor 1-like - Homo sapiens (Human) - MINAR2 gene Indicus|evm.model.CM009497.1.589 Q8TE59 ATS19_HUMAN 79.948 0.381687 0.805302 ADAMTS19 - A disintegrin and metalloproteinase with thrombospondin motifs 19 precursor - Homo sapiens (Human) - ADAMTS19 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization Indicus|evm.model.CM009497.1.590 A6QLY4 ISOC1_BOVIN 100.000 0.991525 0.791946 ISOC1 - Isochorismatase domain-containing protein 1 - Bos taurus (Bovine) - ISOC1 gene cytoplasm Indicus|evm.model.CM009497.1.591 Q9Y2P4 S27A6_HUMAN 80.383 0.477958 0.696284 SLC27A6 - Long-chain fatty acid transport protein 6 - Homo sapiens (Human) - SLC27A6 gene Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart (PubMed:12556534). Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs) (By similarity). Indicus|evm.model.CM009497.1.592 P35556 FBN2_HUMAN 95.437 0.958717 0.931662 FBN2 - Fibrillin-2 precursor - Homo sapiens (Human) - FBN2 gene Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Indicus|evm.model.CM009497.1.593 P55011 S12A2_HUMAN 94.806 0.99834 0.994224 SLC12A2 - Solute carrier family 12 member 2 - Homo sapiens (Human) - SLC12A2 gene Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume. Indicus|evm.model.CM009497.1.594 P0DO97 CC192_HUMAN 82.222 0.695312 0.438356 CCDC192 - Coiled-coil domain-containing protein 192 - Homo sapiens (Human) - CCDC192 gene Indicus|evm.model.CM009497.1.595 Q8BXZ0 CTXN3_MOUSE 95.062 0.97561 1.025 Ctxn3 - Cortexin-3 - Mus musculus (Mouse) - Ctxn3 gene Indicus|evm.model.CM009497.1.596 Q96M27 PRRC1_HUMAN 97.153 0.59322 1.06067 PRRC1 - Protein PRRC1 - Homo sapiens (Human) - PRRC1 gene cytoplasm, protein kinase A regulatory subunit binding, activation of protein kinase A activity Indicus|evm.model.CM009497.1.597 Q96KG7 MEG10_HUMAN 95.741 0.988566 0.997368 MEGF10 - Multiple epidermal growth factor-like domains protein 10 precursor - Homo sapiens (Human) - MEGF10 gene Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568, PubMed:17643423). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977, Ref.14). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:17498693, PubMed:17643423, PubMed:20828568, PubMed:22101682, PubMed:27170117, PubMed:28498977). Indicus|evm.model.CM009497.1.598 A6NC05 YD286_HUMAN 85.965 0.482759 0.84058 C5orf63 - Glutaredoxin-like protein C5orf63 - Homo sapiens (Human) - C5orf63 gene Indicus|evm.model.CM009497.1.599 P20290 BTF3_HUMAN 87.248 0.859649 0.830097 BTF3 - Transcription factor BTF3 - Homo sapiens (Human) - BTF3 gene When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. Indicus|evm.model.CM009497.1.600 A2ALU4 SHRM2_MOUSE 70.909 0.225 0.162053 Shroom2 - Protein Shroom2 - Mus musculus (Mouse) - Shroom2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution. Indicus|evm.model.CM009497.1.601 A0JN69 MARH3_BOVIN 100.000 0.992126 1.00395 MARCHF3 - E3 ubiquitin-protein ligase MARCHF3 - Bos taurus (Bovine) - MARCHF3 gene E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Indicus|evm.model.CM009497.1.602 P20700 LMNB1_HUMAN 90.445 0.996694 1.03242 LMNB1 - Lamin-B1 precursor - Homo sapiens (Human) - LMNB1 gene Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Indicus|evm.model.CM009497.1.603 A8SMG2 TEX43_BOVIN 100.000 0.985075 1.00752 TEX43 - Testis-expressed protein 43 - Bos taurus (Bovine) - TEX43 gene Indicus|evm.model.CM009497.1.604 Q3MHI4 PHAX_BOVIN 100.000 0.994937 1.00254 PHAX - Phosphorylated adapter RNA export protein - Bos taurus (Bovine) - PHAX gene A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA (By similarity). Indicus|evm.model.CM009497.1.605 Q2KJC9 AL7A1_BOVIN 100.000 0.411168 0.365492 ALDH7A1 - Alpha-aminoadipic semialdehyde dehydrogenase precursor - Bos taurus (Bovine) - ALDH7A1 gene Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). Indicus|evm.model.CM009497.1.606 Q2KJC9 AL7A1_BOVIN 99.629 0.996296 1.00186 ALDH7A1 - Alpha-aminoadipic semialdehyde dehydrogenase precursor - Bos taurus (Bovine) - ALDH7A1 gene Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). Indicus|evm.model.CM009497.1.607 Q5R8N8 GRM2B_PONAB 87.409 0.932127 0.991031 GRAMD2B - GRAM domain-containing protein 2B - Pongo abelii (Sumatran orangutan) - GRAMD2B gene cytoplasmic microtubule Indicus|evm.model.CM009497.1.609 Q3SZY3 PTTG1_BOVIN 90.099 0.990148 1.00495 PTTG1 - Securin - Bos taurus (Bovine) - PTTG1 gene Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity). Indicus|evm.model.CM009497.1.611 Q9ULD9 ZN608_HUMAN 94.518 0.998676 0.999339 ZNF608 - Zinc finger protein 608 - Homo sapiens (Human) - ZNF608 gene Transcription factor, which represses ZNF609 transcription. Indicus|evm.model.CM009497.1.613 Q92900 RENT1_HUMAN 47.101 0.541284 0.193091 UPF1 - Regulator of nonsense transcripts 1 - Homo sapiens (Human) - UPF1 gene RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability. Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA hardoring long 3'UTR by inducing the NMD machinery (By similarity). Indicus|evm.model.CM009497.1.614 Q5R893 H2B1_PONAB 96.032 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009497.1.615 Q5R4V3 KC1G3_PONAB 98.684 0.995614 1 CSNK1G3 - Casein kinase I isoform gamma-3 - Pongo abelii (Sumatran orangutan) - CSNK1G3 gene Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Indicus|evm.model.CM009497.1.616 A0JN62 CE120_BOVIN 99.493 0.997976 1.00101 CEP120 - Centrosomal protein of 120 kDa - Bos taurus (Bovine) - CEP120 gene Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity). Indicus|evm.model.CM009497.1.617 A6QPM3 PRDM6_BOVIN 100.000 0.996616 1.00169 PRDM6 - Putative histone-lysine N-methyltransferase PRDM6 - Bos taurus (Bovine) - PRDM6 gene Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. Indicus|evm.model.CM009497.1.618 Q08E11 PPIC_BOVIN 100.000 0.99061 1.00472 PPIC - Peptidyl-prolyl cis-trans isomerase C - Bos taurus (Bovine) - PPIC gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Indicus|evm.model.CM009497.1.619 Q17QS1 SNX24_BOVIN 98.817 0.988235 1.00592 SNX24 - Sorting nexin-24 - Bos taurus (Bovine) - SNX24 gene May be involved in several stages of intracellular trafficking. Indicus|evm.model.CM009497.1.620 Q2TBW7 SNX2_BOVIN 99.615 0.996154 1.00193 SNX2 - Sorting nexin-2 - Bos taurus (Bovine) - SNX2 gene Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (By similarity). Indicus|evm.model.CM009497.1.621 Q9Y6H5 SNCAP_HUMAN 89.239 0.945361 1.0555 SNCAIP - Synphilin-1 - Homo sapiens (Human) - SNCAIP gene Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. Indicus|evm.model.CM009497.1.623 A6QQM4 ZN474_BOVIN 99.737 0.994751 0.839207 ZNF474 - Zinc finger protein 474 - Bos taurus (Bovine) - ZNF474 gene Indicus|evm.model.CM009497.1.624 P33072 LYOX_BOVIN 99.522 0.995227 1.00239 LOX - Protein-lysine 6-oxidase precursor - Bos taurus (Bovine) - LOX gene Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). Indicus|evm.model.CM009497.1.625 Q05B65 SRFB1_BOVIN 94.393 0.995074 0.948598 SRFBP1 - Serum response factor-binding protein 1 - Bos taurus (Bovine) - SRFBP1 gene May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). Indicus|evm.model.CM009497.1.626 Q2YDI9 FTMT_BOVIN 98.760 0.99177 1.00413 FTMT - Ferritin, mitochondrial precursor - Bos taurus (Bovine) - FTMT gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Indicus|evm.model.CM009497.1.627 P05387 RLA2_HUMAN 98.485 0.560345 1.0087 RPLP2 - 60S acidic ribosomal protein P2 - Homo sapiens (Human) - RPLP2 gene Plays an important role in the elongation step of protein synthesis. Indicus|evm.model.CM009497.1.628 Q8TBA6 GOGA5_HUMAN 75.141 0.956044 0.248974 GOLGA5 - Golgin subfamily A member 5 - Homo sapiens (Human) - GOLGA5 gene Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. Indicus|evm.model.CM009497.1.629 Q66LM5 F170A_MACFA 45.198 0.508671 1.22261 FAM170A - Protein FAM170A - Macaca fascicularis (Crab-eating macaque) - FAM170A gene Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE) (By similarity). Indicus|evm.model.CM009497.1.630 Q08E26 CRTC2_BOVIN 65.479 0.63786 0.701299 CRTC2 - CREB-regulated transcription coactivator 2 - Bos taurus (Bovine) - CRTC2 gene Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). Indicus|evm.model.CM009497.1.631 P62912 RL32_RAT 74.074 0.97561 0.607407 Rpl32 - 60S ribosomal protein L32 - Rattus norvegicus (Rat) - Rpl32 gene cytosolic large ribosomal subunit, polysomal ribosome, cellular response to dexamethasone stimulus, cytoplasmic translation, liver regeneration Indicus|evm.model.CM009497.1.632 Q569H4 LARGN_HUMAN 90.837 0.988142 0.832237 PRR16 - Protein Largen - Homo sapiens (Human) - PRR16 gene Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration. Indicus|evm.model.CM009497.1.633 P68105 EF1A1_RABIT 97.403 0.99568 1.00216 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009497.1.634 Q9H329 E41LB_HUMAN 92.357 0.742857 0.233333 EPB41L4B - Band 4.1-like protein 4B - Homo sapiens (Human) - EPB41L4B gene Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927). Indicus|evm.model.CM009497.1.635 Q569H4 LARGN_HUMAN 91.228 0.666667 0.276316 PRR16 - Protein Largen - Homo sapiens (Human) - PRR16 gene Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration. Indicus|evm.model.CM009497.1.638 Q2HJF1 RM53_BOVIN 49.383 0.772277 0.901786 MRPL53 - 39S ribosomal protein L53, mitochondrial precursor - Bos taurus (Bovine) - MRPL53 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Indicus|evm.model.CM009497.1.639 A1A519 F170A_HUMAN 72.892 0.993994 1.00909 FAM170A - Protein FAM170A - Homo sapiens (Human) - FAM170A gene Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE). Indicus|evm.model.CM009497.1.640 P51659 DHB4_HUMAN 85.870 0.997286 1.00136 HSD17B4 - Peroxisomal multifunctional enzyme type 2 - Homo sapiens (Human) - HSD17B4 gene Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed:10671535). Indicus|evm.model.CM009497.1.641 A4IF78 TFIP8_BOVIN 100.000 0.59697 1.66667 TNFAIP8 - Tumor necrosis factor alpha-induced protein 8 - Bos taurus (Bovine) - TNFAIP8 gene Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity). Indicus|evm.model.CM009497.1.642 Q9Y485 DMXL1_HUMAN 92.254 0.999337 0.996696 DMXL1 - DmX-like protein 1 - Homo sapiens (Human) - DMXL1 gene RAVE complex, vacuolar acidification Indicus|evm.model.CM009497.1.643 Q8NBA8 DTWD2_HUMAN 71.951 0.618557 0.651007 DTWD2 - tRNA-uridine aminocarboxypropyltransferase 2 - Homo sapiens (Human) - DTWD2 gene Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) (PubMed:31804502). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)) (PubMed:31804502). Indicus|evm.model.CM009497.1.644 Q2HJ75 RITA1_BOVIN 66.667 0.880952 0.312268 RITA1 - RBPJ-interacting and tubulin-associated protein 1 - Bos taurus (Bovine) - RITA1 gene Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity). Indicus|evm.model.CM009497.1.646 Q9H2E6 SEM6A_HUMAN 95.446 0.998058 1 SEMA6A - Semaphorin-6A precursor - Homo sapiens (Human) - SEMA6A gene Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Indicus|evm.model.CM009497.1.647 Q9Y6G5 COMDA_HUMAN 92.793 0.873016 0.623762 COMMD10 - COMM domain-containing protein 10 - Homo sapiens (Human) - COMMD10 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Indicus|evm.model.CM009497.1.648 Q8N8L6 ARL10_HUMAN 91.393 0.991837 1.0041 ARL10 - ADP-ribosylation factor-like protein 10 - Homo sapiens (Human) - ARL10 gene Indicus|evm.model.CM009497.1.649 Q5E996 NOP16_BOVIN 100.000 0.988827 1.00562 NOP16 - Nucleolar protein 16 - Bos taurus (Bovine) - NOP16 gene nucleolus, ribosomal large subunit biogenesis Indicus|evm.model.CM009497.1.650 Q9CQJ1 HIG2A_MOUSE 83.810 0.971963 1.00943 Higd2a - HIG1 domain family member 2A - Mus musculus (Mouse) - Higd2a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes (By similarity). Indicus|evm.model.CM009497.1.651 P04975 CLCB_BOVIN 100.000 0.991266 1.00439 CLTB - Clathrin light chain B - Bos taurus (Bovine) - CLTB gene Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Indicus|evm.model.CM009497.1.652 Q2HJD0 FAF2_BOVIN 100.000 0.995516 1.00225 FAF2 - FAS-associated factor 2 - Bos taurus (Bovine) - FAF2 gene Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. Indicus|evm.model.CM009497.1.653 Q7L0R7 RNF44_HUMAN 93.287 0.995381 1.00231 RNF44 - RING finger protein 44 - Homo sapiens (Human) - RNF44 gene Indicus|evm.model.CM009497.1.654 Q9BYE9 CDHR2_HUMAN 76.274 0.998474 1.00076 CDHR2 - Cadherin-related family member 2 precursor - Homo sapiens (Human) - CDHR2 gene Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771). Indicus|evm.model.CM009497.1.655 Q7Z2K8 GRIN1_HUMAN 58.793 0.99021 0.709325 GPRIN1 - G protein-regulated inducer of neurite outgrowth 1 - Homo sapiens (Human) - GPRIN1 gene May be involved in neurite outgrowth. Indicus|evm.model.CM009497.1.656 P33567 SYUB_BOVIN 99.254 0.985185 1.00746 SNCB - Beta-synuclein - Bos taurus (Bovine) - SNCB gene May be involved in neuronal plasticity. Indicus|evm.model.CM009497.1.657 A6NMX2 I4E1B_HUMAN 88.360 0.810345 0.958678 EIF4E1B - Eukaryotic translation initiation factor 4E type 1B - Homo sapiens (Human) - EIF4E1B gene Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure. Indicus|evm.model.CM009497.1.658 Q58DN3 TSN17_BOVIN 99.630 0.953901 1.04444 TSPAN17 - Tetraspanin-17 - Bos taurus (Bovine) - TSPAN17 gene Regulates ADAM10 maturation. Indicus|evm.model.CM009497.1.659 Q8K1S4 UNC5A_MOUSE 96.009 0.997785 1.00557 Unc5a - Netrin receptor UNC5A precursor - Mus musculus (Mouse) - Unc5a gene Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Indicus|evm.model.CM009497.1.660 P52790 HXK3_HUMAN 90.693 0.997838 1.00217 HK3 - Hexokinase-3 - Homo sapiens (Human) - HK3 gene Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:8717435). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435). Indicus|evm.model.CM009497.1.661 A0P8Z5 UIMC1_PIG 87.293 0.924552 1.0846 UIMC1 - BRCA1-A complex subunit RAP80 - Sus scrofa (Pig) - UIMC1 gene Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. Indicus|evm.model.CM009497.1.662 Q32L68 HM20B_BOVIN 96.622 0.936306 0.990536 HMG20B - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related - Bos taurus (Bovine) - HMG20B gene Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity). Indicus|evm.model.CM009497.1.663 O43447 PPIH_HUMAN 81.921 0.987805 0.926554 PPIH - Peptidyl-prolyl cis-trans isomerase H - Homo sapiens (Human) - PPIH gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. Indicus|evm.model.CM009497.1.664 Q5R4W8 ZN346_PONAB 92.258 0.993548 1 ZNF346 - Zinc finger protein 346 - Pongo abelii (Sumatran orangutan) - ZNF346 gene Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. Indicus|evm.model.CM009497.1.665 P22455 FGFR4_HUMAN 92.893 0.980025 0.998753 FGFR4 - Fibroblast growth factor receptor 4 precursor - Homo sapiens (Human) - FGFR4 gene Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. Indicus|evm.model.CM009497.1.666 Q96L73 NSD1_HUMAN 90.519 0.996296 0.901335 NSD1 - Histone-lysine N-methyltransferase, H3 lysine-36 specific - Homo sapiens (Human) - NSD1 gene Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. Indicus|evm.model.CM009497.1.667 Q969Q5 RAB24_HUMAN 98.522 0.990196 1.00493 RAB24 - Ras-related protein Rab-24 - Homo sapiens (Human) - RAB24 gene May be involved in autophagy-related processes. Indicus|evm.model.CM009497.1.668 Q32KN9 PRLD1_BOVIN 100.000 0.990909 1.00457 PRELID1 - PRELI domain-containing protein 1, mitochondrial precursor - Bos taurus (Bovine) - PRELID1 gene Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs (By similarity). Indicus|evm.model.CM009497.1.669 Q9BW11 MAD3_HUMAN 91.748 0.990338 1.00485 MXD3 - Max dimerization protein 3 - Homo sapiens (Human) - MXD3 gene Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). Indicus|evm.model.CM009497.1.670 Q12907 LMAN2_HUMAN 94.930 0.983333 1.01124 LMAN2 - Vesicular integral-membrane protein VIP36 precursor - Homo sapiens (Human) - LMAN2 gene Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). Indicus|evm.model.CM009497.1.671 O43566 RGS14_HUMAN 89.789 0.996466 1 RGS14 - Regulator of G-protein signaling 14 - Homo sapiens (Human) - RGS14 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. Indicus|evm.model.CM009497.1.672 O97704 NPT2A_SHEEP 97.340 0.996875 1.00156 SLC34A1 - Sodium-dependent phosphate transport protein 2A - Ovis aries (Sheep) - SLC34A1 gene Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. Indicus|evm.model.CM009497.1.673 Q32PB1 PROF3_BOVIN 100.000 0.985507 1.0073 PFN3 - Profilin-3 - Bos taurus (Bovine) - PFN3 gene Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis. Indicus|evm.model.CM009497.1.674 P98140 FA12_BOVIN 98.203 0.996689 0.986928 F12 - Coagulation factor XII precursor - Bos taurus (Bovine) - F12 gene Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). Indicus|evm.model.CM009497.1.675 P43250 GRK6_HUMAN 97.222 0.986278 1.01215 GRK6 - G protein-coupled receptor kinase 6 - Homo sapiens (Human) - GRK6 gene Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). Indicus|evm.model.CM009497.1.677 P0C6T3 PRR7_RAT 96.654 0.992593 1.00372 Prr7 - Proline-rich protein 7 - Rattus norvegicus (Rat) - Prr7 gene Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (PubMed:27458189). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (By similarity). Might promote apoptosis in T cells (By similarity). Indicus|evm.model.CM009497.1.678 Q16643 DREB_HUMAN 89.846 0.981846 1.01849 DBN1 - Drebrin - Homo sapiens (Human) - DBN1 gene Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). Indicus|evm.model.CM009497.1.679 Q9NR12 PDLI7_HUMAN 94.323 0.889105 1.12473 PDLIM7 - PDZ and LIM domain protein 7 - Homo sapiens (Human) - PDLIM7 gene May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). Indicus|evm.model.CM009497.1.680 Q7L591 DOK3_HUMAN 86.957 0.570136 0.891129 DOK3 - Docking protein 3 - Homo sapiens (Human) - DOK3 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). Indicus|evm.model.CM009497.1.681 Q9UJV9 DDX41_HUMAN 99.196 0.988854 1.00965 DDX41 - Probable ATP-dependent RNA helicase DDX41 - Homo sapiens (Human) - DDX41 gene Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. Indicus|evm.model.CM009497.1.682 A7MB40 F193B_BOVIN 100.000 0.439159 1.09842 FAM193B - Protein FAM193B - Bos taurus (Bovine) - FAM193B gene cytoplasm, nucleus Indicus|evm.model.CM009497.1.683 Q99KF1 TMED9_MOUSE 67.662 0.760456 1.11915 Tmed9 - Transmembrane emp24 domain-containing protein 9 precursor - Mus musculus (Mouse) - Tmed9 gene Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity). Indicus|evm.model.CM009497.1.684 P68105 EF1A1_RABIT 95.238 0.995662 0.997835 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009497.1.685 Q3T133 TMED9_BOVIN 100.000 0.991525 1.00426 TMED9 - Transmembrane emp24 domain-containing protein 9 precursor - Bos taurus (Bovine) - TMED9 gene Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity). Indicus|evm.model.CM009497.1.686 Q9UBV7 B4GT7_HUMAN 92.966 0.993902 1.00306 B4GALT7 - Beta-1,4-galactosyltransferase 7 - Homo sapiens (Human) - B4GALT7 gene Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts. Indicus|evm.model.CM009497.1.688 O15049 N4BP3_HUMAN 91.758 0.996324 1 N4BP3 - NEDD4-binding protein 3 - Homo sapiens (Human) - N4BP3 gene Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage. Indicus|evm.model.CM009497.1.689 Q91YQ7 RMD5B_MOUSE 97.118 0.88491 0.994911 Rmnd5b - E3 ubiquitin-protein transferase RMND5B - Mus musculus (Mouse) - Rmnd5b gene Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Indicus|evm.model.CM009497.1.690 Q5E950 NHP2_BOVIN 100.000 0.987013 1.00654 NHP2 - H/ACA ribonucleoprotein complex subunit 2 - Bos taurus (Bovine) - NHP2 gene Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). Indicus|evm.model.CM009497.1.691 Q99729 ROAA_HUMAN 93.994 0.993994 1.00301 HNRNPAB - Heterogeneous nuclear ribonucleoprotein A/B - Homo sapiens (Human) - HNRNPAB gene Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. Indicus|evm.model.CM009497.1.692 Q8IUZ5 AT2L2_HUMAN 91.759 0.993348 1.00222 PHYKPL - 5-phosphohydroxy-L-lysine phospho-lyase - Homo sapiens (Human) - PHYKPL gene Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde. Indicus|evm.model.CM009497.1.694 Q86Y22 CONA1_HUMAN 81.690 0.673077 0.192593 COL23A1 - Collagen alpha-1(XXIII) chain - Homo sapiens (Human) - COL23A1 gene collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular matrix, extracellular space, plasma membrane, extracellular matrix structural constituent, collagen fibril organization, extracellular matrix organization Indicus|evm.model.CM009497.1.695 Q9HAZ1 CLK4_HUMAN 97.297 0.995851 1.00208 CLK4 - Dual specificity protein kinase CLK4 - Homo sapiens (Human) - CLK4 gene Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Indicus|evm.model.CM009497.1.696 O60765 Z354A_HUMAN 89.769 0.864286 1.15702 ZNF354A - Zinc finger protein 354A - Homo sapiens (Human) - ZNF354A gene cytosol, nucleolus, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II, sensory perception of sound Indicus|evm.model.CM009497.1.697 Q8MJI9 PROP1_BOVIN 99.558 0.991189 1.00442 PROP1 - Homeobox protein prophet of Pit-1 - Bos taurus (Bovine) - PROP1 gene Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. Indicus|evm.model.CM009497.1.698 P68105 EF1A1_RABIT 89.238 0.874016 0.549784 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009497.1.699 P27115 MGAT1_RABIT 92.617 0.995536 1.00224 MGAT1 - Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase - Oryctolagus cuniculus (Rabbit) - MGAT1 gene Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. Indicus|evm.model.CM009497.1.701 P62752 RL23A_RAT 92.958 0.686275 0.653846 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009497.1.702 Q6UXG8 BTNL9_HUMAN 69.194 0.789474 0.497196 BTNL9 - Butyrophilin-like protein 9 precursor - Homo sapiens (Human) - BTNL9 gene external side of plasma membrane, plasma membrane, signaling receptor binding, adaptive immune response, regulation of cytokine production, T cell receptor signaling pathway Indicus|evm.model.CM009497.1.703 Q6UXG8 BTNL9_HUMAN 65.882 0.948276 0.433645 BTNL9 - Butyrophilin-like protein 9 precursor - Homo sapiens (Human) - BTNL9 gene external side of plasma membrane, plasma membrane, signaling receptor binding, adaptive immune response, regulation of cytokine production, T cell receptor signaling pathway Indicus|evm.model.CM009497.1.704 Q9C029 TRIM7_HUMAN 89.824 0.996055 0.992172 TRIM7 - E3 ubiquitin-protein ligase TRIM7 - Homo sapiens (Human) - TRIM7 gene E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon (By similarity). Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128). Indicus|evm.model.CM009497.1.705 Q8WV44 TRI41_HUMAN 96.508 0.996825 1 TRIM41 - E3 ubiquitin-protein ligase TRIM41 - Homo sapiens (Human) - TRIM41 gene Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C. Indicus|evm.model.CM009497.1.706 P63245 RACK1_RAT 100.000 0.993711 1.00315 Rack1 - Receptor of activated protein C kinase 1 - Rattus norvegicus (Rat) - Rack1 gene Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:15340087). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane. Indicus|evm.model.CM009497.1.707 Q8WV44 TRI41_HUMAN 77.885 0.279133 0.585714 TRIM41 - E3 ubiquitin-protein ligase TRIM41 - Homo sapiens (Human) - TRIM41 gene Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C. Indicus|evm.model.CM009497.1.711 Q96IT1 ZN496_HUMAN 83.673 0.996599 1.0017 ZNF496 - Zinc finger protein 496 - Homo sapiens (Human) - ZNF496 gene DNA-binding transcription factor that can both act as an activator and a repressor. Indicus|evm.model.CM009497.1.712 A6QLE5 NLRP3_BOVIN 89.331 0.997949 0.945684 NLRP3 - NACHT, LRR and PYD domains-containing protein 3 - Bos taurus (Bovine) - NLRP3 gene As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (By similarity). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. However, it is unclear what constitutes the direct NLRP3 activator. Activation in presence of cytosolic dsRNA is mediated by DHX33 (By similarity). Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth. During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). Indicus|evm.model.CM009497.1.713 O95918 OR2H2_HUMAN 60.690 0.947368 0.487179 OR2H2 - Olfactory receptor 2H2 - Homo sapiens (Human) - OR2H2 gene Odorant receptor. Indicus|evm.model.CM009497.1.714 Q8N628 OR2C3_HUMAN 85.057 0.945355 0.571875 OR2C3 - Olfactory receptor 2C3 - Homo sapiens (Human) - OR2C3 gene Odorant receptor. Indicus|evm.model.CM009497.1.715 Q5JQS6 GSAML_HUMAN 56.643 0.692308 1.44444 GCSAML - Germinal center-associated signaling and motility-like protein - Homo sapiens (Human) - GCSAML gene Indicus|evm.model.CM009497.1.716 Q8VGR9 O1044_MOUSE 47.000 0.970779 0.980892 Olfr1044 - Olfactory receptor 1044 - Mus musculus (Mouse) - Olfr1044 gene Potential odorant receptor. Indicus|evm.model.CM009497.1.717 Q9UGF6 OR5V1_HUMAN 59.406 0.980198 0.314642 OR5V1 - Olfactory receptor 5V1 - Homo sapiens (Human) - OR5V1 gene Odorant receptor. Indicus|evm.model.CM009497.1.718 Q5E9Y2 STX17_BOVIN 84.783 0.387931 0.384106 STX17 - Syntaxin-17 - Bos taurus (Bovine) - STX17 gene SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity). Indicus|evm.model.CM009497.1.719 Q8NG77 O2T12_HUMAN 72.941 0.960227 0.55 OR2T12 - Olfactory receptor 2T12 - Homo sapiens (Human) - OR2T12 gene Odorant receptor. Indicus|evm.model.CM009497.1.720 Q8NG06 TRI58_HUMAN 82.062 0.991803 1.00412 TRIM58 - E3 ubiquitin-protein ligase TRIM58 - Homo sapiens (Human) - TRIM58 gene E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. Indicus|evm.model.CM009497.1.721 Q8NG80 OR2L5_HUMAN 81.041 0.971014 0.884615 OR2L5 - Olfactory receptor 2L5 - Homo sapiens (Human) - OR2L5 gene Odorant receptor. Indicus|evm.model.CM009497.1.723 Q8NGY9 OR2L8_HUMAN 81.116 0.991453 0.75 OR2L8 - Olfactory receptor 2L8 - Homo sapiens (Human) - OR2L8 gene Odorant receptor. Indicus|evm.model.CM009497.1.725 Q6EE22 UNK_CANLF 88.406 0.384181 0.218519 UNK - RING finger protein unkempt homolog - Canis lupus familiaris (Dog) - UNK gene Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes. Indicus|evm.model.CM009497.1.726 Q5TZ20 OR2G6_HUMAN 55.882 0.827869 0.386076 OR2G6 - Olfactory receptor 2G6 - Homo sapiens (Human) - OR2G6 gene Odorant receptor. Indicus|evm.model.CM009497.1.727 P51989 RO21_XENLA 75.377 0.775591 0.734104 Heterogeneous nuclear ribonucleoprotein A2 homolog 1 - Xenopus laevis (African clawed frog) Indicus|evm.model.CM009497.1.728 Q8NH03 OR2T3_HUMAN 78.667 0.949045 0.493711 OR2T3 - Olfactory receptor 2T3 - Homo sapiens (Human) - OR2T3 gene Odorant receptor. Indicus|evm.model.CM009497.1.730 A2VE33 LYPD8_BOVIN 95.279 0.97479 1.03478 LYPD8 - Ly6/PLAUR domain-containing protein 8 precursor - Bos taurus (Bovine) - LYPD8 gene Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis. Indicus|evm.model.CM009497.1.731 Q0V8K7 3BP5L_BOVIN 99.693 0.788835 1.07013 SH3BP5L - SH3 domain-binding protein 5-like - Bos taurus (Bovine) - SH3BP5L gene Functions as guanine nucleotide exchange factor (GEF) for RAB11A. Indicus|evm.model.CM009497.1.732 Q499Z4 ZN672_HUMAN 80.435 0.982833 1.03097 ZNF672 - Zinc finger protein 672 - Homo sapiens (Human) - ZNF672 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009497.1.733 A0JNJ4 ZN692_BOVIN 99.609 0.973282 1.02745 ZNF692 - Zinc finger protein 692 - Bos taurus (Bovine) - ZNF692 gene May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. Indicus|evm.model.CM009497.1.734 Q6P3X8 PGBD2_HUMAN 90.085 0.874063 1.12669 PGBD2 - PiggyBac transposable element-derived protein 2 - Homo sapiens (Human) - PGBD2 gene sequence-specific DNA binding Indicus|evm.model.CM009497.1.735 O75899 GABR2_HUMAN 91.304 0.542169 0.088204 GABBR2 - Gamma-aminobutyric acid type B receptor subunit 2 precursor - Homo sapiens (Human) - GABBR2 gene Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Indicus|evm.model.CM009497.1.737 E9Q6I0 V2116_MOUSE 73.196 0.536313 0.209112 Vmn2r116 - Vomeronasal type-2 receptor 116 precursor - Mus musculus (Mouse) - Vmn2r116 gene Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation. Indicus|evm.model.CM009497.1.738 Q9Z2V6 HDAC5_MOUSE 62.500 0.177966 0.318059 Hdac5 - Histone deacetylase 5 - Mus musculus (Mouse) - Hdac5 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). Serves as a corepressor of RARA and causes its deacetylation (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity). Indicus|evm.model.CM009497.1.739 Q2HJ61 PLPP2_BOVIN 99.303 0.993056 1.00348 PLPP2 - Phospholipid phosphatase 2 - Bos taurus (Bovine) - PLPP2 gene Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (By similarity). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity). Indicus|evm.model.CM009497.1.740 A5PJX4 MIER2_BOVIN 99.463 0.911765 1.09091 MIER2 - Mesoderm induction early response protein 2 - Bos taurus (Bovine) - MIER2 gene Transcriptional repressor. Indicus|evm.model.CM009497.1.741 Q9JMB1 THEG_MOUSE 72.611 0.816754 1.01867 Theg - Testicular haploid expressed gene protein - Mus musculus (Mouse) - Theg gene May be involved (but not essential) in spermatogenesis. Indicus|evm.model.CM009497.1.742 Q68FD7 FNIP1_MOUSE 59.649 0.746479 0.0609442 Fnip1 - Folliculin-interacting protein 1 - Mus musculus (Mouse) - Fnip1 gene Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:23582324). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases (By similarity). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (By similarity). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (By similarity). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (By similarity). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Required for B-cell development (PubMed:22709692, PubMed:27303042). Indicus|evm.model.CM009497.1.743 Q8TF44 C2C4C_HUMAN 89.598 0.995249 1 C2CD4C - C2 calcium-dependent domain-containing protein 4C - Homo sapiens (Human) - C2CD4C gene Indicus|evm.model.CM009497.1.744 O70142 SHC2_RAT 87.528 0.995392 0.757417 Shc2 - SHC-transforming protein 2 - Rattus norvegicus (Rat) - Shc2 gene Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity). Indicus|evm.model.CM009497.1.745 Q3SX64 OD3L2_HUMAN 82.182 0.985612 0.961938 ODF3L2 - Outer dense fiber protein 3-like protein 2 - Homo sapiens (Human) - ODF3L2 gene cytoplasmic microtubule, cytoskeleton Indicus|evm.model.CM009497.1.747 Q13477 MADCA_HUMAN 55.782 0.670588 1.11257 MADCAM1 - Mucosal addressin cell adhesion molecule 1 precursor - Homo sapiens (Human) - MADCAM1 gene Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. Indicus|evm.model.CM009497.1.748 P49427 UB2R1_HUMAN 95.595 0.435798 2.17797 CDC34 - Ubiquitin-conjugating enzyme E2 R1 - Homo sapiens (Human) - CDC34 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:10329681, PubMed:10373550, PubMed:10871850, PubMed:11675391, PubMed:12037680, PubMed:15652359, PubMed:17461777, PubMed:17698585, PubMed:19112177, PubMed:19126550, PubMed:19945379, PubMed:20061386, PubMed:20347421). Indicus|evm.model.CM009497.1.749 P51124 GRAM_HUMAN 69.636 0.945946 1.00778 GZMM - Granzyme M precursor - Homo sapiens (Human) - GZMM gene Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. Indicus|evm.model.CM009497.1.750 Q9UL51 HCN2_HUMAN 98.673 0.70245 0.964004 HCN2 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 - Homo sapiens (Human) - HCN2 gene Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). Indicus|evm.model.CM009497.1.751 O00411 RPOM_HUMAN 68.171 0.998363 0.993496 POLRMT - DNA-directed RNA polymerase, mitochondrial precursor - Homo sapiens (Human) - POLRMT gene DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Indicus|evm.model.CM009497.1.752 Q9ESS2 FGF22_MOUSE 77.083 0.836257 1.05556 Fgf22 - Fibroblast growth factor 22 precursor - Mus musculus (Mouse) - Fgf22 gene Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. Indicus|evm.model.CM009497.1.753 Q7T0Q3 R126A_XENLA 82.639 0.412104 1.11218 rnf126-a - E3 ubiquitin-protein ligase RNF126-A - Xenopus laevis (African clawed frog) - rnf126-a gene E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. Indicus|evm.model.CM009497.1.754 Q1LZB9 FSTL3_BOVIN 100.000 0.992366 1.00383 FSTL3 - Follistatin-related protein 3 precursor - Bos taurus (Bovine) - FSTL3 gene The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity). Indicus|evm.model.CM009497.1.755 Q6UWY2 PRS57_HUMAN 77.899 0.915825 1.04947 PRSS57 - Serine protease 57 precursor - Homo sapiens (Human) - PRSS57 gene Serine protease that cleaves preferentially after Arg residues (PubMed:22474388, PubMed:23904161, PubMed:25156428). Can also cleave after citrulline (deimidated arginine) and methylarginine residues (PubMed:25156428). Indicus|evm.model.CM009497.1.757 Q2MJV8 PALM_PIG 87.855 0.929952 1.06977 PALM - Paralemmin-1 precursor - Sus scrofa (Pig) - PALM gene Involved in plasma membrane dynamics and cell process formation. Necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner (By similarity). Indicus|evm.model.CM009497.1.758 Q8IVT2 MISP_HUMAN 59.945 0.997101 1.0162 MISP - Mitotic interactor and substrate of PLK1 - Homo sapiens (Human) - MISP gene Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. Indicus|evm.model.CM009497.1.759 P20160 CAP7_HUMAN 79.757 0.991903 0.984064 AZU1 - Azurocidin precursor - Homo sapiens (Human) - AZU1 gene This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. Indicus|evm.model.CM009497.1.760 Q61096 PRTN3_MOUSE 70.281 0.957198 1.01181 Prtn3 - Myeloblastin precursor - Mus musculus (Mouse) - Prtn3 gene Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177. Indicus|evm.model.CM009497.1.761 Q3UP87 ELNE_MOUSE 77.328 0.914179 1.01132 Elane - Neutrophil elastase precursor - Mus musculus (Mouse) - Elane gene Medullasin modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (By similarity). Capable of killing E.coli; probably digests outer membrane protein A (ompA) in E.coli (PubMed:10947984). Indicus|evm.model.CM009497.1.762 Q29099 PTBP1_PIG 97.666 0.996416 1.0018 PTBP1 - Polypyrimidine tract-binding protein 1 - Sus scrofa (Pig) - PTBP1 gene Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (By similarity). Indicus|evm.model.CM009497.1.763 Q6T4P5 PLPR3_HUMAN 86.093 0.957537 0.655989 PLPPR3 - Phospholipid phosphatase-related protein type 3 - Homo sapiens (Human) - PLPPR3 gene integral component of plasma membrane, lipid phosphatase activity, phosphatidate phosphatase activity, phospholipid dephosphorylation, phospholipid metabolic process, signal transduction Indicus|evm.model.CM009497.1.764 Q3T0A3 CFAD_BOVIN 100.000 0.992308 1.00386 CFD - Complement factor D precursor - Bos taurus (Bovine) - CFD gene Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity). Indicus|evm.model.CM009497.1.765 Q9Y2X0 MED16_HUMAN 94.297 0.284783 1.04903 MED16 - Mediator of RNA polymerase II transcription subunit 16 - Homo sapiens (Human) - MED16 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Indicus|evm.model.CM009497.1.766 Q2KIL7 R3HD4_BOVIN 100.000 0.992674 1.00368 R3HDM4 - R3H domain-containing protein 4 - Bos taurus (Bovine) - R3HDM4 gene Indicus|evm.model.CM009497.1.767 Q969F8 KISSR_HUMAN 83.554 0.992084 0.952261 KISS1R - KiSS-1 receptor - Homo sapiens (Human) - KISS1R gene Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. Indicus|evm.model.CM009497.1.768 Q99856 ARI3A_HUMAN 82.558 0.996627 1 ARID3A - AT-rich interactive domain-containing protein 3A - Homo sapiens (Human) - ARID3A gene Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. Indicus|evm.model.CM009497.1.769 Q3SZD4 WDR18_BOVIN 100.000 0.968539 1.03009 WDR18 - WD repeat-containing protein 18 - Bos taurus (Bovine) - WDR18 gene Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). May play a role during development (By similarity). Indicus|evm.model.CM009497.1.770 O60391 NMD3B_HUMAN 80.546 0.975225 0.85139 GRIN3B - Glutamate receptor ionotropic, NMDA 3B precursor - Homo sapiens (Human) - GRIN3B gene NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. Indicus|evm.model.CM009497.1.771 Q3TBD2 HMHA1_MOUSE 91.379 0.0899054 0.5681 Arhgap45 - Rho GTPase-activating protein 45 - Mus musculus (Mouse) - Arhgap45 gene Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. Indicus|evm.model.CM009497.1.772 Q3SYU6 CNN2_BOVIN 100.000 0.737789 1.2589 CNN2 - Calponin-2 - Bos taurus (Bovine) - CNN2 gene Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). Indicus|evm.model.CM009497.1.773 Q8IZY2 ABCA7_HUMAN 82.508 0.999071 1.00326 ABCA7 - Phospholipid-transporting ATPase ABCA7 - Homo sapiens (Human) - ABCA7 gene Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). Indicus|evm.model.CM009497.1.774 Q92619 HMHA1_HUMAN 85.714 0.161253 0.758803 ARHGAP45 - Rho GTPase-activating protein 45 - Homo sapiens (Human) - ARHGAP45 gene Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. Indicus|evm.model.CM009497.1.775 Q5R587 RPAB1_PONAB 99.524 0.990521 1.00476 POLR2E - DNA-directed RNA polymerases I, II, and III subunit RPABC1 - Pongo abelii (Sumatran orangutan) - POLR2E gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity). Indicus|evm.model.CM009497.1.776 Q9N2J2 GPX4_BOVIN 92.893 0.98913 0.93401 GPX4 - Phospholipid hydroperoxide glutathione peroxidase precursor - Bos taurus (Bovine) - GPX4 gene Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). Indicus|evm.model.CM009497.1.777 A0JND4 SBNO2_BOVIN 100.000 0.998545 1.00073 SBNO2 - Protein strawberry notch homolog 2 - Bos taurus (Bovine) - SBNO2 gene Seems to have transcriptional repression activity in macrophages. Indicus|evm.model.CM009497.1.779 Q15831 STK11_HUMAN 97.619 0.722543 0.399538 STK11 - Serine/threonine-protein kinase STK11 precursor - Homo sapiens (Human) - STK11 gene Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). Indicus|evm.model.CM009497.1.780 Q9WTK7 STK11_MOUSE 89.879 0.626598 0.896789 Stk11 - Serine/threonine-protein kinase STK11 precursor - Mus musculus (Mouse) - Stk11 gene Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). Indicus|evm.model.CM009497.1.781 Q8N350 CBARP_HUMAN 80.822 0.632371 1.1305 CBARP - Voltage-dependent calcium channel beta subunit-associated regulatory protein - Homo sapiens (Human) - CBARP gene Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. Indicus|evm.model.CM009497.1.782 P05630 ATPD_BOVIN 100.000 0.462857 2.08333 ATP5F1D - ATP synthase subunit delta, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1D gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Indicus|evm.model.CM009497.1.783 Q504T8 MIDN_HUMAN 87.420 0.995595 0.970085 MIDN - Midnolin - Homo sapiens (Human) - MIDN gene Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. Indicus|evm.model.CM009497.1.784 Q5RF83 CIRBP_PONAB 98.214 0.36087 2.67442 CIRBP - Cold-inducible RNA-binding protein - Pongo abelii (Sumatran orangutan) - CIRBP gene Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed (By similarity). Indicus|evm.model.CM009497.1.785 Q08DK9 PWP3A_BOVIN 99.844 0.996885 1.00156 PWWP3A - PWWP domain-containing DNA repair factor 3A - Bos taurus (Bovine) - PWWP3A gene Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity). Indicus|evm.model.CM009497.1.786 P42026 NDUS7_BOVIN 100.000 0.990783 1.00463 NDUFS7 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor - Bos taurus (Bovine) - NDUFS7 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for the catalytic activity of complex I (By similarity). Indicus|evm.model.CM009497.1.787 Q2TBQ3 GAMT_BOVIN 100.000 0.991561 1.00424 GAMT - Guanidinoacetate N-methyltransferase - Bos taurus (Bovine) - GAMT gene Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development. Indicus|evm.model.CM009497.1.788 Q96EP5 DAZP1_HUMAN 94.962 0.954106 1.0172 DAZAP1 - DAZ-associated protein 1 - Homo sapiens (Human) - DAZAP1 gene RNA-binding protein, which may be required during spermatogenesis. Indicus|evm.model.CM009497.1.789 Q56K10 RS15_BOVIN 100.000 0.986301 1.0069 RPS15 - 40S ribosomal protein S15 - Bos taurus (Bovine) - RPS15 gene cytosolic small ribosomal subunit, structural constituent of ribosome, ribosomal small subunit assembly Indicus|evm.model.CM009497.1.790 O95996 APCL_HUMAN 81.889 0.988586 0.989145 APC2 - Adenomatous polyposis coli protein 2 - Homo sapiens (Human) - APC2 gene Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329). Indicus|evm.model.CM009497.1.791 Q1LZF3 CS025_BOVIN 100.000 0.983193 1.00847 UPF0449 protein C19orf25 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009497.1.792 Q6UW60 PCSK4_HUMAN 78.682 0.941094 0.944371 PCSK4 - Proprotein convertase subtilisin/kexin type 4 precursor - Homo sapiens (Human) - PCSK4 gene Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806). May also participate in folliculogenesis in the ovaries (By similarity). Indicus|evm.model.CM009497.1.793 Q32LG5 REEP6_BOVIN 100.000 0.380846 2.42703 REEP6 - Receptor expression-enhancing protein 6 - Bos taurus (Bovine) - REEP6 gene Required for correct function and survival of retinal photoreceptors (By similarity). Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity). Indicus|evm.model.CM009497.1.794 Q6ZMM2 ATL5_HUMAN 79.032 0.902439 0.426195 ADAMTSL5 - ADAMTS-like protein 5 precursor - Homo sapiens (Human) - ADAMTSL5 gene May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM). Indicus|evm.model.CM009497.1.795 Q4FZD7 PLK5_MOUSE 63.255 0.823161 1.07395 Plk5 - Inactive serine/threonine-protein kinase PLK5 - Mus musculus (Mouse) - Plk5 gene Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation. Indicus|evm.model.CM009497.1.796 Q86XN8 MEX3D_HUMAN 85.371 0.653736 1.06912 MEX3D - RNA-binding protein MEX3D - Homo sapiens (Human) - MEX3D gene RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. Indicus|evm.model.CM009497.1.797 O95983 MBD3_HUMAN 97.175 0.768559 0.786942 MBD3 - Methyl-CpG-binding domain protein 3 - Homo sapiens (Human) - MBD3 gene Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. Indicus|evm.model.CM009497.1.798 O95983 MBD3_HUMAN 92.593 0.582418 0.312715 MBD3 - Methyl-CpG-binding domain protein 3 - Homo sapiens (Human) - MBD3 gene Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. Indicus|evm.model.CM009497.1.799 P07552 QCR10_BOVIN 100.000 0.964912 1.01786 UQCR11 - Cytochrome b-c1 complex subunit 10 - Bos taurus (Bovine) - UQCR11 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability. Indicus|evm.model.CM009497.1.800 P15923 TFE2_HUMAN 79.389 0.996875 0.978593 TCF3 - Transcription factor E2-alpha - Homo sapiens (Human) - TCF3 gene Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with TCF15, required for the mesenchymal to epithelial transition. Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). Indicus|evm.model.CM009497.1.801 Q8K557 ONEC3_MOUSE 100.000 0.394366 0.289796 Onecut3 - One cut domain family member 3 - Mus musculus (Mouse) - Onecut3 gene Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Indicus|evm.model.CM009497.1.802 O60422 ONEC3_HUMAN 92.233 0.689189 0.299595 ONECUT3 - One cut domain family member 3 - Homo sapiens (Human) - ONECUT3 gene Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity). Indicus|evm.model.CM009497.1.803 O60423 AT8B3_HUMAN 72.132 0.871977 1.08154 ATP8B3 - Phospholipid-transporting ATPase IK - Homo sapiens (Human) - ATP8B3 gene P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida. Indicus|evm.model.CM009497.1.804 Q8N1G1 REXO1_HUMAN 78.746 0.998344 0.989353 REXO1 - RNA exonuclease 1 homolog - Homo sapiens (Human) - REXO1 gene Seems to have no detectable effect on transcription elongation in vitro. Indicus|evm.model.CM009497.1.805 P58334 KLF16_MOUSE 94.000 0.526596 0.749004 Klf16 - Krueppel-like factor 16 - Mus musculus (Mouse) - Klf16 gene Transcription factor that binds GC and GT boxes in the D1A, D2 and D3 dopamine receptor promoters and displaces Sp1 and Sp3 from these sequences. It modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context. Indicus|evm.model.CM009497.1.806 Q2HJ19 AB17A_BOVIN 99.677 0.993569 1.00323 ABHD17A - Alpha/beta hydrolase domain-containing protein 17A - Bos taurus (Bovine) - ABHD17A gene Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6. Indicus|evm.model.CM009497.1.807 Q96EY9 ADAT3_HUMAN 82.440 0.956395 0.980057 ADAT3 - Probable inactive tRNA-specific adenosine deaminase-like protein 3 - Homo sapiens (Human) - ADAT3 gene nucleoplasm, tRNA modification Indicus|evm.model.CM009497.1.808 Q58DF6 SCAM4_BOVIN 100.000 0.991342 1.00435 SCAMP4 - Secretory carrier-associated membrane protein 4 - Bos taurus (Bovine) - SCAMP4 gene Probably involved in membrane protein trafficking. Indicus|evm.model.CM009497.1.809 P78368 KC1G2_HUMAN 95.663 0.995181 1 CSNK1G2 - Casein kinase I isoform gamma-2 - Homo sapiens (Human) - CSNK1G2 gene Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. Indicus|evm.model.CM009497.1.810 Q9BX70 BTBD2_HUMAN 98.131 0.829126 0.980952 BTBD2 - BTB/POZ domain-containing protein 2 - Homo sapiens (Human) - BTBD2 gene cytosol, P-body, neurogenesis Indicus|evm.model.CM009497.1.811 Q2M3V2 SWAHA_HUMAN 77.289 0.964539 1.02732 SOWAHA - Ankyrin repeat domain-containing protein SOWAHA precursor - Homo sapiens (Human) - SOWAHA gene Indicus|evm.model.CM009497.1.812 Q2M3G4 SHRM1_HUMAN 74.286 0.0913907 0.88615 SHROOM1 - Protein Shroom1 - Homo sapiens (Human) - SHROOM1 gene May be involved in the assembly of microtubule arrays during cell elongation. Indicus|evm.model.CM009497.1.813 Q9GK68 GDF9_BOVIN 100.000 0.994536 0.807947 GDF9 - Growth/differentiation factor 9 precursor - Bos taurus (Bovine) - GDF9 gene Required for ovarian folliculogenesis. Indicus|evm.model.CM009497.1.814 P13271 QCR8_BOVIN 100.000 0.604478 1.63415 UQCRQ - Cytochrome b-c1 complex subunit 8 - Bos taurus (Bovine) - UQCRQ gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Indicus|evm.model.CM009497.1.815 Q9UHB7 AFF4_HUMAN 96.134 0.998283 1.00172 AFF4 - AF4/FMR2 family member 4 - Homo sapiens (Human) - AFF4 gene Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. Indicus|evm.model.CM009497.1.816 Q9CX48 ZCH10_MOUSE 93.333 0.432749 0.960674 Zcchc10 - Zinc finger CCHC domain-containing protein 10 - Mus musculus (Mouse) - Zcchc10 gene Indicus|evm.model.CM009497.1.817 Q58DW5 RL5_BOVIN 94.872 0.885496 0.441077 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Indicus|evm.model.CM009497.1.818 P34932 HSP74_HUMAN 97.738 0.997622 1.00119 HSPA4 - Heat shock 70 kDa protein 4 - Homo sapiens (Human) - HSPA4 gene cytosol, extracellular exosome, nucleus, ATP binding, chaperone-mediated protein complex assembly, protein insertion into mitochondrial outer membrane, response to unfolded protein Indicus|evm.model.CM009497.1.819 Q6MZW2 FSTL4_HUMAN 80.905 0.947443 0.836105 FSTL4 - Follistatin-related protein 4 precursor - Homo sapiens (Human) - FSTL4 gene cell differentiation, multicellular organism development Indicus|evm.model.CM009497.1.820 Q6MZW2 FSTL4_HUMAN 75.281 0.536585 0.194774 FSTL4 - Follistatin-related protein 4 precursor - Homo sapiens (Human) - FSTL4 gene cell differentiation, multicellular organism development Indicus|evm.model.CM009497.1.823 Q5R5B8 KCT2_PONAB 78.113 0.992453 1 KCT2 - Keratinocyte-associated transmembrane protein 2 precursor - Pongo abelii (Sumatran orangutan) - KCT2 gene Indicus|evm.model.CM009497.1.824 Q9TT15 VDAC1_RABIT 100.000 0.903846 1.10247 VDAC1 - Voltage-dependent anion-selective channel protein 1 - Oryctolagus cuniculus (Rabbit) - VDAC1 gene Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. May mediate ATP export from cells. Indicus|evm.model.CM009497.1.825 P36402 TCF7_HUMAN 90.448 0.780374 1.11458 TCF7 - Transcription factor 7 - Homo sapiens (Human) - TCF7 gene Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. Indicus|evm.model.CM009497.1.826 Q71U00 SKP1_XENLA 100.000 0.987805 1.00613 skp1 - S-phase kinase-associated protein 1 - Xenopus laevis (African clawed frog) - skp1 gene Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). Indicus|evm.model.CM009497.1.827 P67777 PP2AA_RABIT 100.000 0.993548 1.00324 PPP2CA - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform - Oryctolagus cuniculus (Rabbit) - PPP2CA gene PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (By similarity). Indicus|evm.model.CM009497.1.828 Q4R8T9 CDKL3_MACFA 84.669 0.965928 0.994915 CDKL3 - Cyclin-dependent kinase-like 3 - Macaca fascicularis (Crab-eating macaque) - CDKL3 gene Indicus|evm.model.CM009497.1.829 P63149 UBE2B_RAT 100.000 0.986928 1.00658 Ube2b - Ubiquitin-conjugating enzyme E2 B - Rattus norvegicus (Rat) - Ube2b gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. Indicus|evm.model.CM009497.1.830 Q24JY8 C2AIL_BOVIN 100.000 0.82963 1.16379 CDKN2AIPNL - CDKN2AIP N-terminal-like protein - Bos taurus (Bovine) - CDKN2AIPNL gene nucleolus, nucleoplasm Indicus|evm.model.CM009497.1.832 Q6ZQF7 JADE2_MOUSE 90.264 0.941847 1.0579 Jade2 - E3 ubiquitin-protein ligase Jade-2 - Mus musculus (Mouse) - Jade2 gene Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (By similarity). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself (PubMed:25018020). Positive regulator of neurogenesis (PubMed:25018020). Indicus|evm.model.CM009497.1.833 Q3T0T7 SAR1B_BOVIN 100.000 0.98995 1.00505 SAR1B - GTP-binding protein SAR1b - Bos taurus (Bovine) - SAR1B gene Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). Indicus|evm.model.CM009497.1.834 A6QNT8 SC24A_BOVIN 99.636 0.998182 1.00091 SEC24A - Protein transport protein Sec24A - Bos taurus (Bovine) - SEC24A gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes. Indicus|evm.model.CM009497.1.835 P49069 CAMLG_HUMAN 93.515 0.993174 0.989865 CAMLG - Guided entry of tail-anchored proteins factor CAMLG - Homo sapiens (Human) - CAMLG gene Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539). Required for the stability of GET1 (PubMed:32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304). Essential for the survival of peripheral follicular B cells (By similarity). Indicus|evm.model.CM009497.1.836 Q7L014 DDX46_HUMAN 99.607 0.842454 1.16974 DDX46 - Probable ATP-dependent RNA helicase DDX46 - Homo sapiens (Human) - DDX46 gene Plays an essential role in splicing, either prior to, or during splicing A complex formation. Indicus|evm.model.CM009497.1.837 Q96J42 TXD15_HUMAN 85.955 0.898219 1.09167 TXNDC15 - Thioredoxin domain-containing protein 15 precursor - Homo sapiens (Human) - TXNDC15 gene Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Involved in ciliogenesis (PubMed:27894351). Indicus|evm.model.CM009497.1.838 Q9H0N5 PHS2_HUMAN 89.623 0.981308 0.823077 PCBD2 - Pterin-4-alpha-carbinolamine dehydratase 2 - Homo sapiens (Human) - PCBD2 gene Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Indicus|evm.model.CM009497.1.839 Q86XQ3 CTSR3_HUMAN 78.000 0.993355 0.756281 CATSPER3 - Cation channel sperm-associated protein 3 - Homo sapiens (Human) - CATSPER3 gene Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Indicus|evm.model.CM009497.1.840 P78337 PITX1_HUMAN 98.408 0.993651 1.00318 PITX1 - Pituitary homeobox 1 - Homo sapiens (Human) - PITX1 gene Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Indicus|evm.model.CM009497.1.841 O75367 H2AY_HUMAN 99.194 0.994624 1 MACROH2A1 - Core histone macro-H2A.1 - Homo sapiens (Human) - MACROH2A1 gene Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708). Indicus|evm.model.CM009497.1.842 Q6ZNK6 TIFAB_HUMAN 76.398 0.717489 1.38509 TIFAB - TRAF-interacting protein with FHA domain-containing protein B - Homo sapiens (Human) - TIFAB gene Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA. Indicus|evm.model.CM009497.1.843 Q92886 NGN1_HUMAN 85.425 0.991935 1.04641 NEUROG1 - Neurogenin-1 - Homo sapiens (Human) - NEUROG1 gene Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). Indicus|evm.model.CM009497.1.844 O95715 CXL14_HUMAN 97.590 0.82 0.900901 CXCL14 - C-X-C motif chemokine 14 precursor - Homo sapiens (Human) - CXCL14 gene Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. Indicus|evm.model.CM009497.1.846 Q3MHI3 S2548_BOVIN 99.678 0.945122 1.05466 SLC25A48 - Solute carrier family 25 member 48 - Bos taurus (Bovine) - SLC25A48 gene acyl carnitine transmembrane transporter activity, acyl carnitine transport, amino acid transport Indicus|evm.model.CM009497.1.847 P15248 IL9_HUMAN 59.712 0.971831 0.986111 IL9 - Interleukin-9 precursor - Homo sapiens (Human) - IL9 gene Supports IL-2 independent and IL-4 independent growth of helper T-cells. Indicus|evm.model.CM009497.1.848 Q3ZBA7 FXL21_BOVIN 99.078 0.995402 1.0023 FBXL21 - F-box/LRR-repeat protein 21 - Bos taurus (Bovine) - FBXL21 gene Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity). Indicus|evm.model.CM009497.1.849 O62644 LECT2_BOVIN 100.000 0.986842 1.00662 LECT2 - Leukocyte cell-derived chemotaxin-2 precursor - Bos taurus (Bovine) - LECT2 gene Has a neutrophil chemotactic activity (PubMed:9524238). Also a positive regulator of chondrocyte proliferation (PubMed:10050029, PubMed:8798437). Indicus|evm.model.CM009497.1.850 P55906 BGH3_BOVIN 100.000 0.987597 0.944363 TGFBI - Transforming growth factor-beta-induced protein ig-h3 precursor - Bos taurus (Bovine) - TGFBI gene Plays a role in cell adhesion (By similarity). May play a role in cell-collagen interactions (By similarity). Indicus|evm.model.CM009497.1.851 P0CG89 H4_SOYBN 85.938 0.346154 1.76699 Histone H4 - Glycine max (Soybean) Indicus|evm.model.CM009497.1.852 Q5R6H7 SMAD5_PONAB 100.000 0.995708 1.00215 SMAD5 - Mothers against decapentaplegic homolog 5 - Pongo abelii (Sumatran orangutan) - SMAD5 gene Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity). Indicus|evm.model.CM009497.1.853 A0A1B0GUA5 SIM32_HUMAN 92.233 0.980769 1.00971 SMIM32 - Small integral membrane protein 32 - Homo sapiens (Human) - SMIM32 gene Indicus|evm.model.CM009497.1.855 Q9HCX4 TRPC7_HUMAN 90.937 0.785973 0.959397 TRPC7 - Short transient receptor potential channel 7 - Homo sapiens (Human) - TRPC7 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion. Indicus|evm.model.CM009497.1.857 Q08629 TICN1_HUMAN 94.695 0.994709 0.861048 SPOCK1 - Testican-1 precursor - Homo sapiens (Human) - SPOCK1 gene May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system. Indicus|evm.model.CM009497.1.858 Q08629 TICN1_HUMAN 93.548 0.484127 0.287016 SPOCK1 - Testican-1 precursor - Homo sapiens (Human) - SPOCK1 gene May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system. Indicus|evm.model.CM009497.1.859 F1MBP6 KLHL3_BOVIN 99.830 0.996599 1.0017 KLHL3 - Kelch-like protein 3 - Bos taurus (Bovine) - KLHL3 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). Indicus|evm.model.CM009497.1.860 Q13151 ROA0_HUMAN 99.020 0.993464 1.00328 HNRNPA0 - Heterogeneous nuclear ribonucleoprotein A0 - Homo sapiens (Human) - HNRNPA0 gene mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. Indicus|evm.model.CM009497.1.861 Q9UBF9 MYOTI_HUMAN 92.369 0.650524 1.53414 MYOT - Myotilin - Homo sapiens (Human) - MYOT gene Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells. Indicus|evm.model.CM009497.1.863 Q9NZM6 PK2L2_HUMAN 85.256 0.99362 1.00481 PKD2L2 - Polycystic kidney disease 2-like 2 protein - Homo sapiens (Human) - PKD2L2 gene May function as a subunit of a cation channel and play a role in fertilization. Indicus|evm.model.CM009497.1.864 Q9NYF5 FA13B_HUMAN 95.881 0.562581 0.846995 FAM13B - Protein FAM13B - Homo sapiens (Human) - FAM13B gene cytosol, regulation of small GTPase mediated signal transduction Indicus|evm.model.CM009497.1.866 Q9H1J5 WNT8A_HUMAN 91.168 0.994318 1.00285 WNT8A - Protein Wnt-8a precursor - Homo sapiens (Human) - WNT8A gene Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. Indicus|evm.model.CM009497.1.867 P56597 NDK5_HUMAN 91.388 0.41517 2.36321 NME5 - Nucleoside diphosphate kinase homolog 5 - Homo sapiens (Human) - NME5 gene Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). Indicus|evm.model.CM009497.1.868 Q9H0E9 BRD8_HUMAN 97.222 0.225603 0.77166 BRD8 - Bromodomain-containing protein 8 - Homo sapiens (Human) - BRD8 gene May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Indicus|evm.model.CM009497.1.869 A1A4R8 CDC23_BOVIN 98.725 0.978571 0.938023 CDC23 - Cell division cycle protein 23 homolog - Bos taurus (Bovine) - CDC23 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Indicus|evm.model.CM009497.1.870 O60609 GFRA3_HUMAN 82.749 0.936709 0.9875 GFRA3 - GDNF family receptor alpha-3 precursor - Homo sapiens (Human) - GFRA3 gene Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. Indicus|evm.model.CM009497.1.871 A5D7P0 MPIP3_BOVIN 89.308 0.995316 0.895178 CDC25C - M-phase inducer phosphatase 3 - Bos taurus (Bovine) - CDC25C gene Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activate its kinase activity (By similarity). Indicus|evm.model.CM009497.1.872 Q9YGP6 SLBP2_XENLA 76.471 0.175532 0.752 slbp2 - Oocyte-specific histone RNA stem-loop-binding protein 2 - Xenopus laevis (African clawed frog) - slbp2 gene Binds the stem-loop structure of replication-dependent histone mRNAs. Is associated with translationally inactive histone mRNA stored in oocytes. Could be a specific translational repressor. Not involved in histone pre-mRNA processing. Indicus|evm.model.CM009497.1.873 Q29RM2 FA53C_BOVIN 100.000 0.994911 1.00255 FAM53C - Protein FAM53C - Bos taurus (Bovine) - FAM53C gene nucleus, protein import into nucleus Indicus|evm.model.CM009497.1.874 Q7LBC6 KDM3B_HUMAN 96.256 0.998864 0.999432 KDM3B - Lysine-specific demethylase 3B - Homo sapiens (Human) - KDM3B gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Indicus|evm.model.CM009497.1.875 Q2KI30 REEP2_BOVIN 100.000 0.992157 1.00394 REEP2 - Receptor expression-enhancing protein 2 - Bos taurus (Bovine) - REEP2 gene Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). Indicus|evm.model.CM009497.1.876 Q29W20 EGR1_BOVIN 99.262 0.996317 1.00556 EGR1 - Early growth response protein 1 - Bos taurus (Bovine) - EGR1 gene Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). Indicus|evm.model.CM009497.1.877 Q5U2Q7 ERF1_RAT 100.000 0.995434 1.00229 Etf1 - Eukaryotic peptide chain release factor subunit 1 - Rattus norvegicus (Rat) - Etf1 gene Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Indicus|evm.model.CM009497.1.878 Q3ZCH0 GRP75_BOVIN 99.853 0.997059 1.00147 HSPA9 - Stress-70 protein, mitochondrial precursor - Bos taurus (Bovine) - HSPA9 gene Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis probably via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Indicus|evm.model.CM009497.1.879 Q3MHM6 CTNA1_BOVIN 99.777 0.840675 1.1777 CTNNA1 - Catenin alpha-1 - Bos taurus (Bovine) - CTNNA1 gene Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation (By similarity). Indicus|evm.model.CM009497.1.880 Q32KV6 SIL1_BOVIN 100.000 0.99568 1.00216 SIL1 - Nucleotide exchange factor SIL1 precursor - Bos taurus (Bovine) - SIL1 gene Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5 (By similarity). Indicus|evm.model.CM009497.1.882 P43243 MATR3_HUMAN 93.311 0.997773 1.06021 MATR3 - Matrin-3 - Homo sapiens (Human) - MATR3 gene May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233). Indicus|evm.model.CM009497.1.885 Q3ZC67 PAIP2_BOVIN 100.000 0.984 1.00806 PAIP2 - Polyadenylate-binding protein-interacting protein 2 - Bos taurus (Bovine) - PAIP2 gene Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity). Indicus|evm.model.CM009497.1.886 Q9UHI7 S23A1_HUMAN 91.405 0.996689 1.01003 SLC23A1 - Solute carrier family 23 member 1 - Homo sapiens (Human) - SLC23A1 gene Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. Indicus|evm.model.CM009497.1.887 A5PJ93 MZB1_BOVIN 100.000 0.989474 1.00529 MZB1 - Marginal zone B- and B1-cell-specific protein precursor - Bos taurus (Bovine) - MZB1 gene Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation (By similarity). Indicus|evm.model.CM009497.1.888 E7EW31 PROB1_HUMAN 73.386 0.998037 1.00394 PROB1 - Proline-rich basic protein 1 - Homo sapiens (Human) - PROB1 gene nucleoplasm Indicus|evm.model.CM009497.1.889 Q4R7I4 SPA24_MACFA 94.634 0.990291 1.00488 SPATA24 - Spermatogenesis-associated protein 24 - Macaca fascicularis (Crab-eating macaque) - SPATA24 gene Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity). Indicus|evm.model.CM009497.1.890 Q5EA26 DJC18_BOVIN 100.000 0.994429 1.00279 DNAJC18 - DnaJ homolog subfamily C member 18 - Bos taurus (Bovine) - DNAJC18 gene endoplasmic reticulum membrane, Hsp70 protein binding, cellular response to misfolded protein, chaperone cofactor-dependent protein refolding, ubiquitin-dependent ERAD pathway Indicus|evm.model.CM009497.1.891 P0C8R9 ECSCR_CANLF 84.746 0.502146 1.33143 ECSCR - Endothelial cell-specific chemotaxis regulator precursor - Canis lupus familiaris (Dog) - ECSCR gene Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2 (By similarity). Indicus|evm.model.CM009497.1.892 A0A1B0GW64 SIM33_HUMAN 68.939 0.907801 1.06818 SMIM33 - Small integral membrane protein 33 - Homo sapiens (Human) - SMIM33 gene Indicus|evm.model.CM009497.1.893 Q2KI99 STING_BOVIN 99.735 0.994723 1.00265 STING1 - Stimulator of interferon genes protein - Bos taurus (Bovine) - STING1 gene Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of c-di-GMP or cGAMP, STING oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state. In addition to promote the production of type I interferons, plays a direct role in autophagy. Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome. The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (By similarity). Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy (By similarity). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP. The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free-ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons (By similarity). May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) (By similarity). Indicus|evm.model.CM009497.1.894 P62840 UB2D2_XENLA 100.000 0.986486 1.0068 ube2d2 - Ubiquitin-conjugating enzyme E2 D2 - Xenopus laevis (African clawed frog) - ube2d2 gene Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Indicus|evm.model.CM009497.1.895 Q32LB3 CXXC5_BOVIN 99.685 0.993711 1.00315 CXXC5 - CXXC-type zinc finger protein 5 - Bos taurus (Bovine) - CXXC5 gene May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity). Indicus|evm.model.CM009497.1.896 Q9BQI7 PSD2_HUMAN 87.739 0.997439 1.01297 PSD2 - PH and SEC7 domain-containing protein 2 - Homo sapiens (Human) - PSD2 gene cleavage furrow, ruffle membrane Indicus|evm.model.CM009497.1.897 P56974 NRG2_MOUSE 96.234 0.922631 0.683862 Nrg2 - Pro-neuregulin-2, membrane-bound isoform precursor - Mus musculus (Mouse) - Nrg2 gene Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. Indicus|evm.model.CM009497.1.898 O14511 NRG2_HUMAN 96.785 0.666667 0.547059 NRG2 - Pro-neuregulin-2, membrane-bound isoform precursor - Homo sapiens (Human) - NRG2 gene Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. Indicus|evm.model.CM009497.1.899 Q00577 PURA_HUMAN 100.000 0.79868 0.940994 PURA - Transcriptional activator protein Pur-alpha - Homo sapiens (Human) - PURA gene This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination. Indicus|evm.model.CM009497.1.900 Q32LK2 CYTM1_BOVIN 84.466 0.971429 1.01942 CYSTM1 - Cysteine-rich and transmembrane domain-containing protein 1 - Bos taurus (Bovine) - CYSTM1 gene Indicus|evm.model.CM009497.1.901 Q3SZE2 PFD1_BOVIN 100.000 0.611111 1.62295 PFDN1 - Prefoldin subunit 1 - Bos taurus (Bovine) - PFDN1 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Indicus|evm.model.CM009497.1.902 Q01580 HBEGF_PIG 90.865 0.990431 1.00481 HBEGF - Proheparin-binding EGF-like growth factor precursor - Sus scrofa (Pig) - HBEGF gene Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). Indicus|evm.model.CM009497.1.903 Q96Q91 B3A4_HUMAN 84.506 0.997908 0.972533 SLC4A9 - Anion exchange protein 4 - Homo sapiens (Human) - SLC4A9 gene Probable apical anion exchanger of the kidney cortex. Indicus|evm.model.CM009497.1.904 Q8IWZ3 ANKH1_HUMAN 95.714 0.963174 1.03619 ANKHD1 - Ankyrin repeat and KH domain-containing protein 1 - Homo sapiens (Human) - ANKHD1 gene May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. Indicus|evm.model.CM009497.1.905 Q9HD15 SRA1_HUMAN 85.268 0.982379 0.961864 SRA1 - Steroid receptor RNA activator 1 - Homo sapiens (Human) - SRA1 gene Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. Indicus|evm.model.CM009497.1.906 O95704 APBB3_HUMAN 94.239 0.995893 1.00206 APBB3 - Amyloid-beta A4 precursor protein-binding family B member 3 - Homo sapiens (Human) - APBB3 gene May modulate the internalization of amyloid-beta precursor protein. Indicus|evm.model.CM009497.1.907 L0R6Q1 S35U4_HUMAN 93.204 0.980769 1.00971 SLC35A4 - SLC35A4 upstream open reading frame protein - Homo sapiens (Human) - SLC35A4 gene positive regulation of translation in response to stress Indicus|evm.model.CM009497.1.908 Q05B73 S35A4_BOVIN 100.000 0.993846 1.00309 SLC35A4 - Probable UDP-sugar transporter protein SLC35A4 - Bos taurus (Bovine) - SLC35A4 gene Golgi apparatus, integral component of Golgi membrane Indicus|evm.model.CM009497.1.910 Q95122 CD14_BOVIN 100.000 0.994652 1.00268 CD14 - Monocyte differentiation antigen CD14 precursor - Bos taurus (Bovine) - CD14 gene Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity). Indicus|evm.model.CM009497.1.911 Q96DC7 TMCO6_HUMAN 87.221 0.995951 1.00203 TMCO6 - Transmembrane and coiled-coil domain-containing protein 6 - Homo sapiens (Human) - TMCO6 gene Indicus|evm.model.CM009497.1.912 Q02370 NDUA2_BOVIN 100.000 0.98 1.0101 NDUFA2 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 - Bos taurus (Bovine) - NDUFA2 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009497.1.913 Q58DT8 WDR55_BOVIN 100.000 0.409677 2.43455 WDR55 - WD repeat-containing protein 55 - Bos taurus (Bovine) - WDR55 gene Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). Indicus|evm.model.CM009497.1.914 Q8IYX4 DND1_HUMAN 89.577 0.994382 1.0085 DND1 - Dead end protein homolog 1 - Homo sapiens (Human) - DND1 gene RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). Indicus|evm.model.CM009497.1.915 Q2KI84 HARS1_BOVIN 100.000 0.996078 1.00196 HARS1 - Histidine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - HARS1 gene Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Indicus|evm.model.CM009497.1.916 A5D7V9 SYHM_BOVIN 99.802 0.996055 1.00198 HARS2 - Histidine--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - HARS2 gene Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Indicus|evm.model.CM009497.1.917 Q9CPW7 ZMAT2_MOUSE 100.000 0.99 1.00503 Zmat2 - Zinc finger matrin-type protein 2 - Mus musculus (Mouse) - Zmat2 gene Involved in pre-mRNA splicing as a component of the spliceosome. Indicus|evm.model.CM009497.1.918 Q9UN74 PCDA4_HUMAN 44.586 0.947368 0.160507 PCDHA4 - Protocadherin alpha-4 precursor - Homo sapiens (Human) - PCDHA4 gene Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.919 Q9Y5H7 PCDA5_HUMAN 85.283 0.16027 5.06624 PCDHA5 - Protocadherin alpha-5 precursor - Homo sapiens (Human) - PCDHA5 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.920 Q9Y5I2 PCDAA_HUMAN 84.427 0.332904 2.45886 PCDHA10 - Protocadherin alpha-10 precursor - Homo sapiens (Human) - PCDHA10 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.921 Q9Y5I0 PCDAD_HUMAN 86.176 0.320747 2.53684 PCDHA13 - Protocadherin alpha-13 precursor - Homo sapiens (Human) - PCDHA13 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.922 Q9H158 PCDC1_HUMAN 83.724 0.989011 0.850467 PCDHAC1 - Protocadherin alpha-C1 precursor - Homo sapiens (Human) - PCDHAC1 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.923 Q5RF92 RBBP4_PONAB 92.222 0.738589 0.567059 RBBP4 - Histone-binding protein RBBP4 - Pongo abelii (Sumatran orangutan) - RBBP4 gene Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Indicus|evm.model.CM009497.1.924 Q9Y5I4 PCDC2_HUMAN 93.446 0.998008 0.997021 PCDHAC2 - Protocadherin alpha-C2 precursor - Homo sapiens (Human) - PCDHAC2 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.925 Q5DRE0 PCDB1_PANTR 88.875 0.997558 1.00122 PCDHB1 - Protocadherin beta-1 precursor - Pan troglodytes (Chimpanzee) - PCDHB1 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.926 Q3MI00 DNJB1_BOVIN 79.583 0.991597 0.7 DNAJB1 - DnaJ homolog subfamily B member 1 - Bos taurus (Bovine) - DNAJB1 gene Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Indicus|evm.model.CM009497.1.927 Q5DRD2 PCDB2_PANTR 89.879 0.73494 0.41604 PCDHB2 - Protocadherin beta-2 precursor - Pan troglodytes (Chimpanzee) - PCDHB2 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.928 Q5DRD0 PCDB4_PANTR 85.427 0.997491 1.00252 PCDHB4 - Protocadherin beta-4 precursor - Pan troglodytes (Chimpanzee) - PCDHB4 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.929 Q9Y5E4 PCDB5_HUMAN 75.980 0.994614 0.700629 PCDHB5 - Protocadherin beta-5 precursor - Homo sapiens (Human) - PCDHB5 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.930 Q9Y5E3 PCDB6_HUMAN 82.642 0.994987 1.00504 PCDHB6 - Protocadherin beta-6 precursor - Homo sapiens (Human) - PCDHB6 gene Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.931 Q9Y5E4 PCDB5_HUMAN 86.402 0.877805 0.504403 PCDHB5 - Protocadherin beta-5 precursor - Homo sapiens (Human) - PCDHB5 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.932 Q5DRD4 PCDBI_PANTR 84.557 0.942584 0.530457 PCDHB18 - Protocadherin beta-18 precursor - Pan troglodytes (Chimpanzee) - PCDHB18 gene Potential calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009497.1.933 Q5DRC3 PCDBH_PANTR 83.563 0.997494 1.00377 PCDHB17 - Protocadherin beta-17 precursor - Pan troglodytes (Chimpanzee) - PCDHB17 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.934 P60868 RS20_RAT 92.437 0.983333 1.0084 Rps20 - 40S ribosomal protein S20 - Rattus norvegicus (Rat) - Rps20 gene cytosolic small ribosomal subunit, small ribosomal subunit, synapse, structural constituent of ribosome Indicus|evm.model.CM009497.1.935 Q9NRJ7 PCDBG_HUMAN 83.115 0.332897 2.95361 PCDHB16 - Protocadherin beta-16 precursor - Homo sapiens (Human) - PCDHB16 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.936 Q5DRD9 PCDBA_PANTR 82.603 0.9975 1.00251 PCDHB10 - Protocadherin beta-10 precursor - Pan troglodytes (Chimpanzee) - PCDHB10 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.937 Q5DRD5 PCDBE_PANTR 84.000 0.52905 1.83333 PCDHB14 - Protocadherin beta-14 precursor - Pan troglodytes (Chimpanzee) - PCDHB14 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.938 Q5DRD4 PCDBI_PANTR 82.194 0.971142 1.01142 PCDHB18 - Protocadherin beta-18 precursor - Pan troglodytes (Chimpanzee) - PCDHB18 gene Potential calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009497.1.939 Q9Y5E8 PCDBF_HUMAN 83.312 0.983689 1.01271 PCDHB15 - Protocadherin beta-15 precursor - Homo sapiens (Human) - PCDHB15 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.940 A6YRY8 RSSA_SHEEP 80.952 0.976471 0.288136 RPSA - 40S ribosomal protein SA - Ovis aries (Sheep) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. Indicus|evm.model.CM009497.1.941 Q9BXI2 ORNT2_HUMAN 86.711 0.993377 1.00332 SLC25A2 - Mitochondrial ornithine transporter 2 - Homo sapiens (Human) - SLC25A2 gene Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix. Indicus|evm.model.CM009497.1.942 Q2HJG8 TAF7_BOVIN 99.713 0.994286 1.00287 TAF7 - Transcription initiation factor TFIID subunit 7 - Bos taurus (Bovine) - TAF7 gene Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). Indicus|evm.model.CM009497.1.944 Q5DRC2 PCDG1_PANTR 81.660 0.992602 0.871106 PCDHGA1 - Protocadherin gamma-A1 precursor - Pan troglodytes (Chimpanzee) - PCDHGA1 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.945 Q5DRB8 PCDG2_PANTR 84.653 0.974607 0.887339 PCDHGA2 - Protocadherin gamma-A2 precursor - Pan troglodytes (Chimpanzee) - PCDHGA2 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.946 Q9Y5H0 PCDG3_HUMAN 86.634 0.508186 1.70386 PCDHGA3 - Protocadherin gamma-A3 precursor - Homo sapiens (Human) - PCDHGA3 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.947 Q9Y5G9 PCDG4_HUMAN 86.015 0.988971 0.848233 PCDHGA4 - Protocadherin gamma-A4 precursor - Homo sapiens (Human) - PCDHGA4 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.948 Q5DRA9 PCDGE_PANTR 84.015 0.915909 0.94522 PCDHGB2 - Protocadherin gamma-B2 precursor - Pan troglodytes (Chimpanzee) - PCDHGB2 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.949 Q9Y5G8 PCDG5_HUMAN 83.970 0.248466 3.50161 PCDHGA5 - Protocadherin gamma-A5 precursor - Homo sapiens (Human) - PCDHGA5 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.950 Q9UN71 PCDGG_HUMAN 85.732 0.992537 0.871073 PCDHGB4 - Protocadherin gamma-B4 precursor - Homo sapiens (Human) - PCDHGB4 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.951 Q5DRB2 PCDG8_PANTR 84.328 0.991358 0.869099 PCDHGA8 - Protocadherin gamma-A8 precursor - Pan troglodytes (Chimpanzee) - PCDHGA8 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.952 Q9Y5G0 PCDGH_HUMAN 88.346 0.987608 0.874323 PCDHGB5 - Protocadherin gamma-B5 precursor - Homo sapiens (Human) - PCDHGB5 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.953 Q9Y5F9 PCDGI_HUMAN 86.262 0.483234 1.7957 PCDHGB6 - Protocadherin gamma-B6 precursor - Homo sapiens (Human) - PCDHGB6 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.954 Q5DRC1 PCDGA_PANTR 88.916 0.974576 0.882479 PCDHGA10 - Protocadherin gamma-A10 precursor - Pan troglodytes (Chimpanzee) - PCDHGA10 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.955 Q5DRA5 PCDGJ_PANTR 83.643 0.993827 0.871905 PCDHGB7 - Protocadherin gamma-B7 precursor - Pan troglodytes (Chimpanzee) - PCDHGB7 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.956 O60330 PCDGC_HUMAN 84.994 0.322742 2.56652 PCDHGA12 - Protocadherin gamma-A12 precursor - Homo sapiens (Human) - PCDHGA12 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.957 Q3SYR7 RL9_BOVIN 97.345 0.982456 0.59375 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009497.1.958 Q5DRA4 PCDGK_PANTR 93.342 0.967742 0.896146 PCDHGC3 - Protocadherin gamma-C3 precursor - Pan troglodytes (Chimpanzee) - PCDHGC3 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.959 Q5DRA3 PCDGL_PANTR 94.893 0.484076 1.84115 PCDHGC4 - Protocadherin gamma-C4 precursor - Pan troglodytes (Chimpanzee) - PCDHGC4 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Indicus|evm.model.CM009497.1.960 Q5RB76 HDAC3_PONAB 94.891 0.362416 1.74065 HDAC3 - Histone deacetylase 3 - Pongo abelii (Sumatran orangutan) - HDAC3 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. Contributes, together with XBP1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (By similarity). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity). During the activation phase, promotes the accumulation of ubiquitinated ARNTL/BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and ARNTL/BMAL1 (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity). Indicus|evm.model.CM009497.1.961 Q2KI80 RELL2_BOVIN 99.670 0.993421 1.0033 RELL2 - RELT-like protein 2 - Bos taurus (Bovine) - RELL2 gene Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed. Indicus|evm.model.CM009497.1.962 Q86WN1 FCSD1_HUMAN 92.630 0.997106 1.00145 FCHSD1 - F-BAR and double SH3 domains protein 1 - Homo sapiens (Human) - FCHSD1 gene Promotes actin polymerization mediated by SNX9 and WASL. Indicus|evm.model.CM009497.1.963 Q8WWN8 ARAP3_HUMAN 91.589 0.0698287 0.983161 ARAP3 - Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 - Homo sapiens (Human) - ARAP3 gene Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. Indicus|evm.model.CM009497.1.964 Q08174 PCDH1_HUMAN 96.572 0.808882 1.18962 PCDH1 - Protocadherin-1 precursor - Homo sapiens (Human) - PCDH1 gene May be involved in cell-cell interaction processes and in cell adhesion. Indicus|evm.model.CM009497.1.965 Q14154 DELE1_HUMAN 83.462 0.996161 1.01165 DELE1 - DAP3-binding cell death enhancer 1 precursor - Homo sapiens (Human) - DELE1 gene Key activator of the integrated stress response (ISR) following mitochondrial stress (PubMed:32132706, PubMed:32132707). In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707). Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667). Indicus|evm.model.CM009497.1.966 Q9NPG4 PCD12_HUMAN 87.142 0.958264 1.01182 PCDH12 - Protocadherin-12 precursor - Homo sapiens (Human) - PCDH12 gene Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). Indicus|evm.model.CM009497.1.967 Q9UBS8 RNF14_HUMAN 95.781 0.995789 1.00211 RNF14 - E3 ubiquitin-protein ligase RNF14 - Homo sapiens (Human) - RNF14 gene Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription. Indicus|evm.model.CM009497.1.968 A4FV08 GNPI1_BOVIN 100.000 0.891641 1.11765 GNPDA1 - Glucosamine-6-phosphate isomerase 1 - Bos taurus (Bovine) - GNPDA1 gene Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). Indicus|evm.model.CM009497.1.970 Q8NGF8 OR4B1_HUMAN 51.163 0.988372 0.278317 OR4B1 - Olfactory receptor 4B1 - Homo sapiens (Human) - OR4B1 gene Odorant receptor. Indicus|evm.model.CM009497.1.972 O00370 LORF2_HUMAN 75.776 0.981651 0.256471 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Indicus|evm.model.CM009497.1.973 P08548 LIN1_NYCCO 59.122 0.936508 0.25 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Indicus|evm.model.CM009497.1.974 Q9UN81 LORF1_HUMAN 51.643 0.685065 0.911243 L1RE1 - LINE-1 retrotransposable element ORF1 protein - Homo sapiens (Human) - L1RE1 gene Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. Indicus|evm.model.CM009497.1.975 Q9BT67 NFIP1_HUMAN 96.000 0.765385 1.17647 NDFIP1 - NEDD4 family-interacting protein 1 - Homo sapiens (Human) - NDFIP1 gene Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion (PubMed:26319551). Restricts the production of proinflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC (By similarity). Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells (By similarity). Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS (PubMed:23087404). Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation (PubMed:26363003). In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity (PubMed:19706893). Important for normal development of dendrites and dendritic spines in cortex (By similarity). Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046). Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH (By similarity). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (PubMed:20534535). Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity (PubMed:25801959). Indicus|evm.model.CM009497.1.976 A2VDU1 SPY4_BOVIN 100.000 0.993333 1.00334 SPRY4 - Protein sprouty homolog 4 - Bos taurus (Bovine) - SPRY4 gene Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (By similarity). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (By similarity). Indicus|evm.model.CM009497.1.978 P03968 FGF1_BOVIN 100.000 0.987179 1.00645 FGF1 - Fibroblast growth factor 1 precursor - Bos taurus (Bovine) - FGF1 gene Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis (By similarity). Indicus|evm.model.CM009497.1.979 Q6ZQ82 RHG26_MOUSE 96.148 0.853755 0.932432 Arhgap26 - Rho GTPase-activating protein 26 - Mus musculus (Mouse) - Arhgap26 gene GTPase-activating protein for RHOA and CDC42. Indicus|evm.model.CM009497.1.980 P04150 GCR_HUMAN 93.734 0.997442 1.00644 NR3C1 - Glucocorticoid receptor - Homo sapiens (Human) - NR3C1 gene Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). Indicus|evm.model.CM009497.1.982 Q2T9V7 PREY_BOVIN 77.011 0.858586 0.868421 PREY - Protein preY, mitochondrial precursor - Bos taurus (Bovine) - PREY gene glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, GPI anchor biosynthetic process Indicus|evm.model.CM009497.1.984 Q5E9E8 YIPF5_BOVIN 100.000 0.992248 1.00389 YIPF5 - Protein YIPF5 - Bos taurus (Bovine) - YIPF5 gene Plays a role in transport between endoplasmic reticulum and Golgi. Indicus|evm.model.CM009497.1.985 A4FUC0 RM37_BOVIN 77.477 0.981818 0.260047 MRPL37 - 39S ribosomal protein L37, mitochondrial precursor - Bos taurus (Bovine) - MRPL37 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion Indicus|evm.model.CM009497.1.986 A4FUC0 RM37_BOVIN 77.241 0.985915 0.335697 MRPL37 - 39S ribosomal protein L37, mitochondrial precursor - Bos taurus (Bovine) - MRPL37 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion Indicus|evm.model.CM009497.1.987 Q68DU8 KCD16_HUMAN 97.834 0.873418 0.738318 KCTD16 - BTB/POZ domain-containing protein KCTD16 - Homo sapiens (Human) - KCTD16 gene Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). Indicus|evm.model.CM009497.1.988 Q68DU8 KCD16_HUMAN 93.827 0.875 0.429907 KCTD16 - BTB/POZ domain-containing protein KCTD16 - Homo sapiens (Human) - KCTD16 gene Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). Indicus|evm.model.CM009497.1.990 Q0VBB0 PRLD2_MOUSE 86.076 0.993671 0.892655 Prelid2 - PRELI domain-containing protein 2 - Mus musculus (Mouse) - Prelid2 gene mitochondrial intermembrane space, mitochondrion, phosphatidic acid transfer activity, phospholipid transport Indicus|evm.model.CM009497.1.991 A6NFK2 GRCR2_HUMAN 86.694 0.991903 0.995968 GRXCR2 - Glutaredoxin domain-containing cysteine-rich protein 2 - Homo sapiens (Human) - GRXCR2 gene Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection. Indicus|evm.model.CM009497.1.992 Q8TEC5 SH3R2_HUMAN 88.366 0.983539 1 SH3RF2 - E3 ubiquitin-protein ligase SH3RF2 - Homo sapiens (Human) - SH3RF2 gene Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623). Indicus|evm.model.CM009497.1.993 A1L4L8 PL8L1_HUMAN 92.222 0.695312 0.723164 PLAC8L1 - PLAC8-like protein 1 - Homo sapiens (Human) - PLAC8L1 gene Indicus|evm.model.CM009497.1.994 Q9P2J5 SYLC_HUMAN 92.262 0.998301 1.00085 LARS1 - Leucine--tRNA ligase, cytoplasmic - Homo sapiens (Human) - LARS1 gene Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. Indicus|evm.model.CM009497.1.995 Q9P2N5 RBM27_HUMAN 96.734 0.991404 0.987736 RBM27 - RNA-binding protein 27 - Homo sapiens (Human) - RBM27 gene nucleus, RNA binding Indicus|evm.model.CM009497.1.996 Q63955 PO4F3_MOUSE 99.704 0.9941 1.00296 Pou4f3 - POU domain, class 4, transcription factor 3 - Mus musculus (Mouse) - Pou4f3 gene Acts as a transcriptional activator (PubMed:8290353, PubMed:7935408). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:7935408). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (PubMed:8637595). Indicus|evm.model.CM009497.1.997 O14776 TCRG1_HUMAN 93.443 0.998081 0.948998 TCERG1 - Transcription elongation regulator 1 - Homo sapiens (Human) - TCERG1 gene Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. Indicus|evm.model.CM009497.1.998 Q8TDV0 GP151_HUMAN 86.207 0.995086 0.97136 GPR151 - G-protein coupled receptor 151 - Homo sapiens (Human) - GPR151 gene Proton-sensing G-protein coupled receptor. Indicus|evm.model.CM009497.1.999 Q5R4A2 2ABB_PONAB 100.000 0.995495 1.00226 PPP2R2B - Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform - Pongo abelii (Sumatran orangutan) - PPP2R2B gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Indicus|evm.model.CM009497.1.1001 Q8BGW6 ST32A_MOUSE 91.316 0.994723 0.952261 Stk32a - Serine/threonine-protein kinase 32A - Mus musculus (Mouse) - Stk32a gene protein serine/threonine kinase activity, intracellular signal transduction, peptidyl-serine phosphorylation Indicus|evm.model.CM009497.1.1002 Q14195 DPYL3_HUMAN 98.421 0.996497 1.00175 DPYSL3 - Dihydropyrimidinase-related protein 3 - Homo sapiens (Human) - DPYSL3 gene Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Indicus|evm.model.CM009497.1.1004 Q96AA8 JKIP2_HUMAN 99.751 0.978076 1.01358 JAKMIP2 - Janus kinase and microtubule-interacting protein 2 - Homo sapiens (Human) - JAKMIP2 gene Golgi apparatus Indicus|evm.model.CM009497.1.1005 Q96PL1 SG3A2_HUMAN 78.161 0.897727 0.946237 SCGB3A2 - Secretoglobin family 3A member 2 precursor - Homo sapiens (Human) - SCGB3A2 gene Secreted cytokine-like protein (PubMed:12847263). Binds to the scavenger receptor MARCO (PubMed:12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung (PubMed:24213919). May play a role in fetal lung development and maturation (PubMed:24213919). Promotes branching morphogenesis during early stages of lung development (PubMed:24213919). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity). Indicus|evm.model.CM009497.1.1006 Q3T146 CE046_BOVIN 100.000 0.977528 1.01136 Uncharacterized protein C5orf46 homolog precursor - Bos taurus (Bovine) Indicus|evm.model.CM009497.1.1007 Q9NQ38 ISK5_HUMAN 60.288 0.993282 0.979323 SPINK5 - Serine protease inhibitor Kazal-type 5 precursor - Homo sapiens (Human) - SPINK5 gene Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. Indicus|evm.model.CM009497.1.1008 P08480 IPSG_FELCA 66.667 0.737931 1.30631 Double-headed protease inhibitor, submandibular gland - Felis catus (Cat) Indicus|evm.model.CM009497.1.1010 P58062 ISK7_HUMAN 81.176 0.976744 1.01176 SPINK7 - Serine protease inhibitor Kazal-type 7 precursor - Homo sapiens (Human) - SPINK7 gene Probable serine protease inhibitor. Indicus|evm.model.CM009497.1.1011 Q6PIJ6 FBX38_HUMAN 97.811 0.998318 1.00084 FBXO38 - F-box only protein 38 - Homo sapiens (Human) - FBXO38 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). Indicus|evm.model.CM009497.1.1012 O70528 5HT4R_CAVPO 96.307 0.994334 0.909794 HTR4 - 5-hydroxytryptamine receptor 4 - Cavia porcellus (Guinea pig) - HTR4 gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity). Indicus|evm.model.CM009497.1.1013 Q28044 ADRB2_BOVIN 99.522 0.995227 1.00239 ADRB2 - Beta-2 adrenergic receptor - Bos taurus (Bovine) - ADRB2 gene Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity). Indicus|evm.model.CM009497.1.1014 Q8TF17 S3TC2_HUMAN 87.510 0.90386 1.10637 SH3TC2 - SH3 domain and tetratricopeptide repeat-containing protein 2 - Homo sapiens (Human) - SH3TC2 gene Indicus|evm.model.CM009497.1.1015 O94929 ABLM3_HUMAN 98.097 0.997076 1.00146 ABLIM3 - Actin-binding LIM protein 3 - Homo sapiens (Human) - ABLIM3 gene May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. Indicus|evm.model.CM009497.1.1017 A6QQV9 AF1L1_BOVIN 99.738 0.997382 1.00131 AFAP1L1 - Actin filament-associated protein 1-like 1 - Bos taurus (Bovine) - AFAP1L1 gene May be involved in podosome and invadosome formation. Indicus|evm.model.CM009497.1.1018 Q0P5N5 GRPE2_BOVIN 99.554 0.991111 1.00446 GRPEL2 - GrpE protein homolog 2, mitochondrial precursor - Bos taurus (Bovine) - GRPEL2 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). Indicus|evm.model.CM009497.1.1019 Q0P5H1 PCYXL_BOVIN 99.593 0.995943 1.00203 PCYOX1L - Prenylcysteine oxidase-like precursor - Bos taurus (Bovine) - PCYOX1L gene Probable oxidoreductase. Indicus|evm.model.CM009497.1.1020 Q9UHF5 IL17B_HUMAN 91.667 0.98895 1.00556 IL17B - Interleukin-17B precursor - Homo sapiens (Human) - IL17B gene Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. Indicus|evm.model.CM009497.1.1022 P67829 KC1A_SHEEP 100.000 0.993865 1.00308 CSNK1A1 - Casein kinase I isoform alpha - Ovis aries (Sheep) - CSNK1A1 gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Indicus|evm.model.CM009497.1.1023 A1IGU5 ARH37_HUMAN 85.778 0.917007 1.08889 ARHGEF37 - Rho guanine nucleotide exchange factor 37 - Homo sapiens (Human) - ARHGEF37 gene May act as a guanine nucleotide exchange factor (GEF). Indicus|evm.model.CM009497.1.1024 Q86YN6 PRGC2_HUMAN 80.414 0.998095 1.02639 PPARGC1B - Peroxisome proliferator-activated receptor gamma coactivator 1-beta - Homo sapiens (Human) - PPARGC1B gene Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Indicus|evm.model.CM009497.1.1025 P11541 PDE6A_BOVIN 96.195 0.936927 1.01513 PDE6A - Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha precursor - Bos taurus (Bovine) - PDE6A gene This protein participates in processes of transmission and amplification of the visual signal. Indicus|evm.model.CM009497.1.1027 Q9BEG8 S26A2_BOVIN 99.591 0.997279 1.00136 SLC26A2 - Sulfate transporter - Bos taurus (Bovine) - SLC26A2 gene Sulfate transporter. May play a role in endochondral bone formation. Indicus|evm.model.CM009497.1.1028 Q17RP2 TIGD6_HUMAN 74.046 0.714286 0.349328 TIGD6 - Tigger transposable element-derived protein 6 - Homo sapiens (Human) - TIGD6 gene nucleus, DNA binding Indicus|evm.model.CM009497.1.1030 Q12766 HMGX3_HUMAN 91.091 0.96003 0.878414 HMGXB3 - HMG domain-containing protein 3 - Homo sapiens (Human) - HMGXB3 gene Indicus|evm.model.CM009497.1.1031 P00545 KFMS_FSVMD 83.749 0.95544 0.986708 V-FMS - Tyrosine-protein kinase transforming protein fms - Feline sarcoma virus (strain McDonough) - V-FMS gene Truncated version of the receptor for colony-stimulating factor 1 (CSF-1). Indicus|evm.model.CM009497.1.1032 A2T7H5 CDX1_PONPY 87.681 0.566116 0.913208 CDX1 - Homeobox protein CDX-1 - Pongo pygmaeus (Bornean orangutan) - CDX1 gene Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA. Indicus|evm.model.CM009497.1.1033 Q04649 CDX2_MESAU 92.754 0.53125 0.408946 CDX2 - Homeobox protein CDX-2 - Mesocricetus auratus (Golden hamster) - CDX2 gene Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (PubMed:1358758). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (PubMed:9148757). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (By similarity). Indicus|evm.model.CM009497.1.1034 Q6QNF3 PGFRB_CANLF 92.844 0.93469 1.0689 PDGFRB - Platelet-derived growth factor receptor beta precursor - Canis lupus familiaris (Dog) - PDGFRB gene Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity). Indicus|evm.model.CM009497.1.1035 Q99884 SC6A7_HUMAN 98.428 0.826823 1.20755 SLC6A7 - Sodium-dependent proline transporter - Homo sapiens (Human) - SLC6A7 gene Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals. Indicus|evm.model.CM009497.1.1036 P11275 KCC2A_RAT 97.751 0.995918 1.0251 Camk2a - Calcium/calmodulin-dependent protein kinase type II subunit alpha - Rattus norvegicus (Rat) - Camk2a gene Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). Indicus|evm.model.CM009497.1.1037 Q32KH7 ARSI_CANLF 96.161 0.993043 1.00349 ARSI - Arylsulfatase I precursor - Canis lupus familiaris (Dog) - ARSI gene Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. Indicus|evm.model.CM009497.1.1038 Q13428 TCOF_HUMAN 57.517 0.962303 0.980511 TCOF1 - Treacle protein - Homo sapiens (Human) - TCOF1 gene Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Indicus|evm.model.CM009497.1.1039 P04233 HG2A_HUMAN 81.111 0.992565 0.908784 CD74 - HLA class II histocompatibility antigen gamma chain - Homo sapiens (Human) - CD74 gene Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Indicus|evm.model.CM009497.1.1040 P62264 RS14_MOUSE 100.000 0.986842 1.00662 Rps14 - 40S ribosomal protein S14 - Mus musculus (Mouse) - Rps14 gene cytosol, cytosolic small ribosomal subunit, mitochondrion, nucleolus, postsynaptic density, mRNA 5'-UTR binding, RNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, translation regulator activity Indicus|evm.model.CM009497.1.1041 P52848 NDST1_HUMAN 98.299 0.997735 1.00113 NDST1 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 - Homo sapiens (Human) - NDST1 gene Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:10758005, PubMed:12634318). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (PubMed:10758005, PubMed:12634318). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Indicus|evm.model.CM009497.1.1042 Q8N3V7 SYNPO_HUMAN 83.921 0.800178 1.21206 SYNPO - Synaptopodin - Homo sapiens (Human) - SYNPO gene Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). Indicus|evm.model.CM009497.1.1043 Q8TDC0 MYOZ3_HUMAN 78.884 0.99187 0.98008 MYOZ3 - Myozenin-3 - Homo sapiens (Human) - MYOZ3 gene Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Indicus|evm.model.CM009497.1.1044 Q8BHS3 RBM22_MOUSE 100.000 0.995249 1.00238 Rbm22 - Pre-mRNA-splicing factor RBM22 - Mus musculus (Mouse) - Rbm22 gene Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. Indicus|evm.model.CM009497.1.1045 Q9UJW0 DCTN4_HUMAN 98.043 0.995662 1.00217 DCTN4 - Dynactin subunit 4 - Homo sapiens (Human) - DCTN4 gene Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. Indicus|evm.model.CM009497.1.1046 Q9BZL3 SMIM3_HUMAN 91.667 0.694118 1.41667 SMIM3 - Small integral membrane protein 3 - Homo sapiens (Human) - SMIM3 gene identical protein binding Indicus|evm.model.CM009497.1.1047 Q96RE9 ZN300_HUMAN 84.743 0.846262 1.17384 ZNF300 - Zinc finger protein 300 - Homo sapiens (Human) - ZNF300 gene Has a transcriptional repressor activity. Indicus|evm.model.CM009497.1.1048 P37141 GPX3_BOVIN 95.595 0.99115 1 GPX3 - Glutathione peroxidase 3 precursor - Bos taurus (Bovine) - GPX3 gene Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. Indicus|evm.model.CM009497.1.1049 Q15025 TNIP1_HUMAN 87.284 0.996845 0.996855 TNIP1 - TNFAIP3-interacting protein 1 - Homo sapiens (Human) - TNIP1 gene Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. Indicus|evm.model.CM009497.1.1050 P79134 ANXA6_BOVIN 99.851 0.965517 1.03418 ANXA6 - Annexin A6 - Bos taurus (Bovine) - ANXA6 gene May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Indicus|evm.model.CM009497.1.1051 A6QNP9 CCD69_BOVIN 99.660 0.99322 1.0034 CCDC69 - Coiled-coil domain-containing protein 69 - Bos taurus (Bovine) - CCDC69 gene May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone. Indicus|evm.model.CM009497.1.1052 P17900 SAP3_HUMAN 68.293 0.840206 1.00518 GM2A - Ganglioside GM2 activator precursor - Homo sapiens (Human) - GM2A gene The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (By similarity). Has cholesterol transfer activity (PubMed:17552909). Indicus|evm.model.CM009497.1.1053 Q495N2 S36A3_HUMAN 85.563 0.989474 1.01064 SLC36A3 - Proton-coupled amino acid transporter 3 - Homo sapiens (Human) - SLC36A3 gene amino acid transmembrane transporter activity, amino acid:proton symporter activity, glycine transmembrane transporter activity, L-alanine transmembrane transporter activity, L-proline transmembrane transporter activity, amino acid transmembrane transport, glycine transport, L-alanine transport, proline transmembrane transport, proton transmembrane transport Indicus|evm.model.CM009497.1.1054 Q495M3 S36A2_HUMAN 80.745 0.995859 1 SLC36A2 - Proton-coupled amino acid transporter 2 - Homo sapiens (Human) - SLC36A2 gene Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity). Indicus|evm.model.CM009497.1.1056 Q7Z2H8 S36A1_HUMAN 89.286 0.995807 1.0021 SLC36A1 - Proton-coupled amino acid transporter 1 - Homo sapiens (Human) - SLC36A1 gene Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognizes their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity). Indicus|evm.model.CM009497.1.1058 Q9NYQ8 FAT2_HUMAN 86.772 0.994021 0.730743 FAT2 - Protocadherin Fat 2 precursor - Homo sapiens (Human) - FAT2 gene Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity). Indicus|evm.model.CM009497.1.1059 Q9NYQ8 FAT2_HUMAN 87.332 0.991646 0.275236 FAT2 - Protocadherin Fat 2 precursor - Homo sapiens (Human) - FAT2 gene Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity). Indicus|evm.model.CM009497.1.1060 P13213 SPRC_BOVIN 100.000 0.993421 1.0033 SPARC - SPARC precursor - Bos taurus (Bovine) - SPARC gene Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Indicus|evm.model.CM009497.1.1061 Q9XT28 ATOX1_SHEEP 100.000 0.971014 1.01471 ATOX1 - Copper transport protein ATOX1 - Ovis aries (Sheep) - ATOX1 gene Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity). Indicus|evm.model.CM009497.1.1062 Q32LC7 G3BP1_BOVIN 100.000 0.918812 1.08602 G3BP1 - Ras GTPase-activating protein-binding protein 1 - Bos taurus (Bovine) - G3BP1 gene ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. Indicus|evm.model.CM009497.1.1063 P57695 GLRA1_BOVIN 98.178 0.968468 0.971554 GLRA1 - Glycine receptor subunit alpha-1 precursor - Bos taurus (Bovine) - GLRA1 gene Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (By similarity). Plays an important role in the down-regulation of neuronal excitability (PubMed:11178872). Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). Indicus|evm.model.CM009497.1.1064 Q58CW4 NMUR2_BOVIN 100.000 0.995098 1.00246 NMUR2 - Neuromedin-U receptor 2 - Bos taurus (Bovine) - NMUR2 gene Receptor for the neuromedin-U and neuromedin-S neuropeptides. Indicus|evm.model.CM009497.1.1066 P18621 RL17_HUMAN 89.157 0.589928 0.755435 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009497.1.1067 Q38PU8 GRIA1_MACFA 99.779 0.997795 1.0011 GRIA1 - Glutamate receptor 1 precursor - Macaca fascicularis (Crab-eating macaque) - GRIA1 gene Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Indicus|evm.model.CM009497.1.1068 Q2T9N1 F1142_BOVIN 96.200 0.995859 0.966 FAM114A1 - Protein FAM114A2 - Bos taurus (Bovine) - FAM114A1 gene Indicus|evm.model.CM009497.1.1069 Q28103 MFAP3_BOVIN 99.429 0.479339 2.07429 MFAP3 - Microfibril-associated glycoprotein 3 - Bos taurus (Bovine) - MFAP3 gene Component of the elastin-associated microfibrils. Indicus|evm.model.CM009497.1.1070 Q86SR1 GLT10_HUMAN 94.275 0.934673 0.99005 GALNT10 - Polypeptide N-acetylgalactosaminyltransferase 10 - Homo sapiens (Human) - GALNT10 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates. Indicus|evm.model.CM009497.1.1071 Q0VCE2 HAND1_BOVIN 100.000 0.989744 0.894495 HAND1 - Heart- and neural crest derivatives-expressed protein 1 - Bos taurus (Bovine) - HAND1 gene Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). Indicus|evm.model.CM009497.1.1072 Q9HAJ7 SP30L_HUMAN 98.907 0.635088 1.55738 SAP30L - Histone deacetylase complex subunit SAP30L - Homo sapiens (Human) - SAP30L gene Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). Indicus|evm.model.CM009497.1.1073 O46415 FRIL_BOVIN 94.545 0.72 0.428571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009497.1.1074 O46415 FRIL_BOVIN 94.937 0.975 0.457143 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009497.1.1075 Q6PKG0 LARP1_HUMAN 79.825 0.729032 0.141423 LARP1 - La-related protein 1 - Homo sapiens (Human) - LARP1 gene RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). Indicus|evm.model.CM009497.1.1076 Q6PKG0 LARP1_HUMAN 96.013 0.995807 0.870438 LARP1 - La-related protein 1 - Homo sapiens (Human) - LARP1 gene RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). Indicus|evm.model.CM009497.1.1078 Q9UFF9 CNOT8_HUMAN 100.000 0.993174 1.00342 CNOT8 - CCR4-NOT transcription complex subunit 8 - Homo sapiens (Human) - CNOT8 gene Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. Indicus|evm.model.CM009497.1.1079 Q8TEQ6 GEMI5_HUMAN 85.544 0.997292 0.979443 GEMIN5 - Gem-associated protein 5 - Homo sapiens (Human) - GEMIN5 gene Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:16857593, PubMed:18984161, PubMed:20513430). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:18984161). GEMIN5 acts as the snRNA-binding protein of the SMN complex (PubMed:11714716, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.25). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). Indicus|evm.model.CM009497.1.1080 Q3SZX5 RM22_BOVIN 96.667 0.990521 1.03431 MRPL22 - 39S ribosomal protein L22, mitochondrial precursor - Bos taurus (Bovine) - MRPL22 gene large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, structural constituent of ribosome, ribosome assembly Indicus|evm.model.CM009497.1.1081 P70081 H48_CHICK 88.732 0.786517 0.864078 H4-VIII - Histone H4 type VIII - Gallus gallus (Chicken) - H4-VIII gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009497.1.1082 Q92629 SGCD_HUMAN 97.924 0.993103 1.00346 SGCD - Delta-sarcoglycan - Homo sapiens (Human) - SGCD gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Indicus|evm.model.CM009497.1.1083 Q5FVR0 TIMD2_RAT 51.327 0.818182 0.378223 Timd2 - T-cell immunoglobulin and mucin domain-containing protein 2 precursor - Rattus norvegicus (Rat) - Timd2 gene Probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation (By similarity). Indicus|evm.model.CM009497.1.1084 Q96H15 TIMD4_HUMAN 55.118 0.994135 0.902116 TIMD4 - T-cell immunoglobulin and mucin domain-containing protein 4 precursor - Homo sapiens (Human) - TIMD4 gene Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity). Indicus|evm.model.CM009497.1.1086 P58365 CAD23_RAT 92.523 0.439834 0.072656 Cdh23 - Cadherin-23 precursor - Rattus norvegicus (Rat) - Cdh23 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Indicus|evm.model.CM009497.1.1087 Q5QNS5 HAVR1_MOUSE 51.639 0.248936 1.54098 Havcr1 - Hepatitis A virus cellular receptor 1 homolog precursor - Mus musculus (Mouse) - Havcr1 gene May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair (By similarity). Indicus|evm.model.CM009497.1.1089 Q96D42 HAVR1_HUMAN 61.290 0.184739 1.36813 HAVCR1 - Hepatitis A virus cellular receptor 1 precursor - Homo sapiens (Human) - HAVCR1 gene May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair. Indicus|evm.model.CM009497.1.1090 P70206 PLXA1_MOUSE 65.625 0.969072 0.0512144 Plxna1 - Plexin-A1 precursor - Mus musculus (Mouse) - Plxna1 gene Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Indicus|evm.model.CM009497.1.1091 Q8TDQ0 HAVR2_HUMAN 66.552 0.989324 0.933555 HAVCR2 - Hepatitis A virus cellular receptor 2 precursor - Homo sapiens (Human) - HAVCR2 gene Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity). Indicus|evm.model.CM009497.1.1092 Q3T123 MED7_BOVIN 99.571 0.991453 1.00429 MED7 - Mediator of RNA polymerase II transcription subunit 7 - Bos taurus (Bovine) - MED7 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009497.1.1093 Q66H38 FA71B_RAT 79.661 0.39966 0.90881 Fam71b - Protein FAM71B - Rattus norvegicus (Rat) - Fam71b gene May be involved in RNA biogenesis. Indicus|evm.model.CM009497.1.1094 Q08881 ITK_HUMAN 90.161 0.996587 0.945161 ITK - Tyrosine-protein kinase ITK/TSK - Homo sapiens (Human) - ITK gene Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). Indicus|evm.model.CM009497.1.1096 Q96F07 CYFP2_HUMAN 90.421 0.998362 0.955399 CYFIP2 - Cytoplasmic FMR1-interacting protein 2 - Homo sapiens (Human) - CYFIP2 gene Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Indicus|evm.model.CM009497.1.1097 Q0D2K0 NIPA4_HUMAN 86.386 0.995062 0.869099 NIPAL4 - Magnesium transporter NIPA4 - Homo sapiens (Human) - NIPAL4 gene Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. Indicus|evm.model.CM009497.1.1098 Q9H013 ADA19_HUMAN 86.489 0.980154 0.949738 ADAM19 - Disintegrin and metalloproteinase domain-containing protein 19 precursor - Homo sapiens (Human) - ADAM19 gene Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). Indicus|evm.model.CM009497.1.1099 Q8CGW4 SOX30_MOUSE 83.568 0.829205 0.980818 Sox30 - Transcription factor SOX-30 - Mus musculus (Mouse) - Sox30 gene Acts as both a transcriptional activator and repressor (PubMed:29866902, PubMed:29848638). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:29866902). Binds to its own promoter and activates its own transcription (PubMed:29866902, PubMed:29848638). Required to activate the expression of postmeiotic genes involved in spermiogenesis (PubMed:29866902, PubMed:29848638). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity). Indicus|evm.model.CM009497.1.1100 Q05B50 THG1_BOVIN 100.000 0.993311 1.00336 THG1L - Probable tRNA(His) guanylyltransferase - Bos taurus (Bovine) - THG1L gene Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress. Indicus|evm.model.CM009497.1.1101 P83369 LSM11_HUMAN 84.444 0.994444 1 LSM11 - U7 snRNA-associated Sm-like protein LSm11 - Homo sapiens (Human) - LSM11 gene Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA. Indicus|evm.model.CM009497.1.1102 A7Z035 EPN4_BOVIN 100.000 0.996894 1.00156 CLINT1 - Clathrin interactor 1 - Bos taurus (Bovine) - CLINT1 gene Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity). Indicus|evm.model.CM009497.1.1103 P45973 CBX5_HUMAN 81.579 0.266187 0.727749 CBX5 - Chromobox protein homolog 5 - Homo sapiens (Human) - CBX5 gene Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Indicus|evm.model.CM009497.1.1104 O77689 CCNB2_BOVIN 87.295 0.727545 0.839196 CCNB2 - G2/mitotic-specific cyclin-B2 - Bos taurus (Bovine) - CCNB2 gene Essential for the control of the cell cycle at the G2/M (mitosis) transition. Indicus|evm.model.CM009497.1.1105 Q07802 COE1_MOUSE 99.492 0.996622 1.00169 Ebf1 - Transcription factor COE1 - Mus musculus (Mouse) - Ebf1 gene Key pioneer transcription factor of B-cell specification and commitment (PubMed:1915300, PubMed:7542362, PubMed:23812095). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (PubMed:20876732). Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates (PubMed:23812095, PubMed:20451411). For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage (PubMed:23812095, PubMed:20451411). In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (PubMed:32130892). Indicus|evm.model.CM009497.1.1106 Q96MT1 RN145_HUMAN 90.129 0.984463 1.06787 RNF145 - RING finger protein 145 - Homo sapiens (Human) - RNF145 gene E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately downregulating cholesterol biosynthesis. Indicus|evm.model.CM009497.1.1107 Q8WVY7 UBCP1_HUMAN 100.000 0.99373 1.00314 UBLCP1 - Ubiquitin-like domain-containing CTD phosphatase 1 - Homo sapiens (Human) - UBLCP1 gene Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome. Indicus|evm.model.CM009497.1.1108 P46282 IL12B_BOVIN 99.694 0.993902 1.00306 IL12B - Interleukin-12 subunit beta precursor - Bos taurus (Bovine) - IL12B gene Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Indicus|evm.model.CM009497.1.1109 P35368 ADA1B_HUMAN 96.731 0.996124 0.992308 ADRA1B - Alpha-1B adrenergic receptor - Homo sapiens (Human) - ADRA1B gene This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. Indicus|evm.model.CM009497.1.1110 Q3ZBR5 TTC1_BOVIN 100.000 0.993174 1.00342 TTC1 - Tetratricopeptide repeat protein 1 - Bos taurus (Bovine) - TTC1 gene Indicus|evm.model.CM009497.1.1111 Q96N64 PWP2A_HUMAN 91.667 0.991919 0.655629 PWWP2A - PWWP domain-containing protein 2A - Homo sapiens (Human) - PWWP2A gene H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression. Indicus|evm.model.CM009497.1.1112 Q3T0Z2 FABP6_BOVIN 100.000 0.984496 1.00781 FABP6 - Gastrotropin - Bos taurus (Bovine) - FABP6 gene Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. Stimulates gastric acid and pepsinogen secretion (By similarity). Indicus|evm.model.CM009497.1.1113 Q5SRT8 CCNJL_MOUSE 88.114 0.989664 1 Ccnjl - Cyclin-J-like protein - Mus musculus (Mouse) - Ccnjl gene centrosome, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus, cyclin-dependent protein serine/threonine kinase regulator activity, mitotic cell cycle phase transition, regulation of cyclin-dependent protein serine/threonine kinase activity Indicus|evm.model.CM009497.1.1114 Q9BXJ5 C1QT2_HUMAN 94.035 0.993007 1.00351 C1QTNF2 - Complement C1q tumor necrosis factor-related protein 2 precursor - Homo sapiens (Human) - C1QTNF2 gene Involved in the regulation of lipid metabolism in adipose tissue and liver. Indicus|evm.model.CM009497.1.1115 A4Z945 ZBED8_BOVIN 99.832 0.996639 1.00168 ZBED8 - Protein ZBED8 - Bos taurus (Bovine) - ZBED8 gene Indicus|evm.model.CM009497.1.1116 Q3ZBE5 SLU7_BOVIN 99.829 0.996593 1.00171 SLU7 - Pre-mRNA-splicing factor SLU7 - Bos taurus (Bovine) - SLU7 gene Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Indicus|evm.model.CM009497.1.1117 Q3SZY3 PTTG1_BOVIN 100.000 0.990148 1.00495 PTTG1 - Securin - Bos taurus (Bovine) - PTTG1 gene Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity). Indicus|evm.model.CM009497.1.1118 O94823 AT10B_HUMAN 74.629 0.981036 0.938398 ATP10B - Phospholipid-transporting ATPase VB - Homo sapiens (Human) - ATP10B gene Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. Indicus|evm.model.CM009497.1.1119 O94823 AT10B_HUMAN 79.618 0.987342 0.108145 ATP10B - Phospholipid-transporting ATPase VB - Homo sapiens (Human) - ATP10B gene Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. Indicus|evm.model.CM009497.1.1120 Q9H2H8 PPIL3_HUMAN 95.050 0.884956 0.701863 PPIL3 - Peptidyl-prolyl cis-trans isomerase-like 3 - Homo sapiens (Human) - PPIL3 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Indicus|evm.model.CM009497.1.1121 Q5R893 H2B1_PONAB 87.302 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009497.1.1122 P63138 GBRB2_RAT 99.757 0.995146 0.869198 Gabrb2 - Gamma-aminobutyric acid receptor subunit beta-2 precursor - Rattus norvegicus (Rat) - Gabrb2 gene Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2548852). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Indicus|evm.model.CM009497.1.1123 Q16445 GBRA6_HUMAN 94.855 0.997763 0.986755 GABRA6 - Gamma-aminobutyric acid receptor subunit alpha-6 precursor - Homo sapiens (Human) - GABRA6 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Indicus|evm.model.CM009497.1.1124 P08219 GBRA1_BOVIN 100.000 0.995624 1.00219 GABRA1 - Gamma-aminobutyric acid receptor subunit alpha-1 precursor - Bos taurus (Bovine) - GABRA1 gene Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:3037384). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (By similarity). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Indicus|evm.model.CM009497.1.1125 P18508 GBRG2_RAT 99.326 0.995516 0.957082 Gabrg2 - Gamma-aminobutyric acid receptor subunit gamma-2 precursor - Rattus norvegicus (Rat) - Gabrg2 gene Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2561970). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Indicus|evm.model.CM009497.1.1128 Q13813 SPTN1_HUMAN 99.153 0.89313 0.0529935 SPTAN1 - Spectrin alpha chain, non-erythrocytic 1 - Homo sapiens (Human) - SPTAN1 gene Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Indicus|evm.model.CM009497.1.1129 Q5E9I1 CCNG1_BOVIN 100.000 0.993243 1.00339 CCNG1 - Cyclin-G1 - Bos taurus (Bovine) - CCNG1 gene May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). Indicus|evm.model.CM009497.1.1130 Q9CQ48 NUDC2_MOUSE 99.363 0.987342 1.00637 Nudcd2 - NudC domain-containing protein 2 - Mus musculus (Mouse) - Nudcd2 gene May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. Indicus|evm.model.CM009497.1.1131 O75330 HMMR_HUMAN 83.613 0.99581 0.98895 HMMR - Hyaluronan mediated motility receptor - Homo sapiens (Human) - HMMR gene Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). Indicus|evm.model.CM009497.1.1132 Q29RI9 MAT2B_BOVIN 100.000 0.99403 1.00299 MAT2B - Methionine adenosyltransferase 2 subunit beta - Bos taurus (Bovine) - MAT2B gene Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro). Indicus|evm.model.CM009497.1.1134 Q13796 SHRM2_HUMAN 55.319 0.547619 0.0519802 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Indicus|evm.model.CM009497.1.1135 Q13796 SHRM2_HUMAN 68.085 0.909091 0.0612624 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Indicus|evm.model.CM009497.1.1138 P63219 GBG5_RAT 95.238 0.632653 1.44118 Gng5 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor - Rattus norvegicus (Rat) - Gng5 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009497.1.1139 Q2NKR3 COXM2_BOVIN 100.000 0.965517 0.734177 CMC2 - COX assembly mitochondrial protein 2 homolog - Bos taurus (Bovine) - CMC2 gene May be involved in cytochrome c oxidase biogenesis. Indicus|evm.model.CM009497.1.1140 Q9NT68 TEN2_HUMAN 98.684 0.657895 0.0410959 TENM2 - Teneurin-2 - Homo sapiens (Human) - TENM2 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. Indicus|evm.model.CM009497.1.1143 Q9WTS5 TEN2_MOUSE 100.000 0.866667 0.0325615 Tenm2 - Teneurin-2 - Mus musculus (Mouse) - Tenm2 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 receptor. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer (By similarity). Indicus|evm.model.CM009497.1.1144 Q9WTS5 TEN2_MOUSE 82.243 0.619048 0.0607815 Tenm2 - Teneurin-2 - Mus musculus (Mouse) - Tenm2 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 receptor. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer (By similarity). Indicus|evm.model.CM009497.1.1145 Q9NT68 TEN2_HUMAN 94.317 0.974014 0.804614 TENM2 - Teneurin-2 - Homo sapiens (Human) - TENM2 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. Indicus|evm.model.CM009497.1.1146 Q8IX03 KIBRA_HUMAN 93.890 0.998193 0.994609 WWC1 - Protein KIBRA - Homo sapiens (Human) - WWC1 gene Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. Indicus|evm.model.CM009497.1.1147 A7YW98 SYRC_BOVIN 100.000 0.996974 1.00152 RARS1 - Arginine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - RARS1 gene Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. Indicus|evm.model.CM009497.1.1148 A6NHQ2 FBLL1_HUMAN 96.813 0.755287 0.991018 FBLL1 - rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 - Homo sapiens (Human) - FBLL1 gene S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). Indicus|evm.model.CM009497.1.1149 Q6UXP7 F151B_HUMAN 89.925 0.149162 6.48551 FAM151B - Protein FAM151B - Homo sapiens (Human) - FAM151B gene Indicus|evm.model.CM009497.1.1150 A5PLL1 AN34B_HUMAN 88.911 0.996101 0.998054 ANKRD34B - Ankyrin repeat domain-containing protein 34B - Homo sapiens (Human) - ANKRD34B gene Indicus|evm.model.CM009497.1.1151 P00376 DYR_BOVIN 99.465 0.989362 1.00535 DHFR - Dihydrofolate reductase - Bos taurus (Bovine) - DHFR gene Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity). Indicus|evm.model.CM009497.1.1152 P20585 MSH3_HUMAN 80.906 0.991573 0.939314 MSH3 - DNA mismatch repair protein Msh3 - Homo sapiens (Human) - MSH3 gene Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Indicus|evm.model.CM009497.1.1153 O14827 RGRF2_HUMAN 96.772 0.998387 1.00243 RASGRF2 - Ras-specific guanine nucleotide-releasing factor 2 - Homo sapiens (Human) - RASGRF2 gene Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. Indicus|evm.model.CM009497.1.1154 Q3ZBP1 KCRS_BOVIN 99.761 0.995238 1.00239 CKMT2 - Creatine kinase S-type, mitochondrial precursor - Bos taurus (Bovine) - CKMT2 gene Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). Indicus|evm.model.CM009497.1.1155 Q8N567 ZCHC9_HUMAN 91.882 0.992647 1.00369 ZCCHC9 - Zinc finger CCHC domain-containing protein 9 - Homo sapiens (Human) - ZCCHC9 gene May down-regulate transcription mediated by NF-kappa-B and the serum response element. Indicus|evm.model.CM009497.1.1156 Q8WYK0 ACO12_HUMAN 86.486 0.992832 1.00541 ACOT12 - Acetyl-coenzyme A thioesterase - Homo sapiens (Human) - ACOT12 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16951743). Acyl-coenzyme A thioesterase 12/ACOT12 preferentially hydrolyzes acetyl-CoA (PubMed:16951743). Indicus|evm.model.CM009497.1.1157 P81877 SSBP2_HUMAN 100.000 0.997159 0.975069 SSBP2 - Single-stranded DNA-binding protein 2 - Homo sapiens (Human) - SSBP2 gene cytoplasm, nucleus, single-stranded DNA binding, positive regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated Indicus|evm.model.CM009497.1.1158 Q9H0Y0 ATG10_HUMAN 73.991 0.742268 1.32273 ATG10 - Ubiquitin-like-conjugating enzyme ATG10 - Homo sapiens (Human) - ATG10 gene E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. Indicus|evm.model.CM009497.1.1159 P62268 RS23_RAT 100.000 0.986111 1.00699 Rps23 - 40S ribosomal protein S23 - Rattus norvegicus (Rat) - Rps23 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Indicus|evm.model.CM009497.1.1160 Q52LC2 VAS1L_HUMAN 76.555 0.638889 1.44643 ATP6AP1L - V-type proton ATPase subunit S1-like protein - Homo sapiens (Human) - ATP6AP1L gene plasma membrane proton-transporting V-type ATPase complex, regulation of cellular pH Indicus|evm.model.CM009497.1.1161 Q5RAL1 KISHA_PONAB 88.710 0.358824 2.36111 TMEM167A - Protein kish-A precursor - Pongo abelii (Sumatran orangutan) - TMEM167A gene Involved in the early part of the secretory pathway. Indicus|evm.model.CM009497.1.1162 Q13426 XRCC4_HUMAN 78.274 0.994012 0.994048 XRCC4 - DNA repair protein XRCC4 - Homo sapiens (Human) - XRCC4 gene Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Indicus|evm.model.CM009497.1.1163 P81282 CSPG2_BOVIN 99.169 0.842887 0.717243 VCAN - Versican core protein precursor - Bos taurus (Bovine) - VCAN gene May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. Indicus|evm.model.CM009497.1.1164 P55252 HPLN1_BOVIN 100.000 0.994366 1.00282 HAPLN1 - Hyaluronan and proteoglycan link protein 1 precursor - Bos taurus (Bovine) - HAPLN1 gene Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. Indicus|evm.model.CM009497.1.1165 O43854 EDIL3_HUMAN 98.551 0.995181 0.864583 EDIL3 - EGF-like repeat and discoidin I-like domain-containing protein 3 precursor - Homo sapiens (Human) - EDIL3 gene Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development. Indicus|evm.model.CM009497.1.1166 Q0VC59 NMNA2_BOVIN 84.286 0.932432 0.241042 NMNAT2 - Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 - Bos taurus (Bovine) - NMNAT2 gene Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Indicus|evm.model.CM009497.1.1167 P79398 IF4G2_RABIT 93.103 0.982759 0.0639471 EIF4G2 - Eukaryotic translation initiation factor 4 gamma 2 - Oryctolagus cuniculus (Rabbit) - EIF4G2 gene Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. Indicus|evm.model.CM009497.1.1168 P50243 DCAM_BOVIN 96.226 0.992481 0.796407 AMD1 - S-adenosylmethionine decarboxylase proenzyme precursor - Bos taurus (Bovine) - AMD1 gene Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. Indicus|evm.model.CM009497.1.1170 P09851 RASA1_BOVIN 99.713 0.998086 1.00096 RASA1 - Ras GTPase-activating protein 1 - Bos taurus (Bovine) - RASA1 gene Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. Indicus|evm.model.CM009497.1.1171 Q3ZBL9 CCNH_BOVIN 99.678 0.95679 1.0125 CCNH - Cyclin-H - Bos taurus (Bovine) - CCNH gene Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle (By similarity). Indicus|evm.model.CM009497.1.1172 P51991 ROA3_HUMAN 91.667 0.577419 0.820106 HNRNPA3 - Heterogeneous nuclear ribonucleoprotein A3 - Homo sapiens (Human) - HNRNPA3 gene Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. Indicus|evm.model.CM009497.1.1173 O46415 FRIL_BOVIN 49.606 0.866142 0.725714 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009497.1.1175 P18699 TBB_LYMST 79.630 0.569892 0.837838 Tubulin beta chain - Lymnaea stagnalis (Great pond snail) Indicus|evm.model.CM009497.1.1176 Q8NDZ6 T161B_HUMAN 97.125 0.995902 1.00205 TMEM161B - Transmembrane protein 161B - Homo sapiens (Human) - TMEM161B gene Indicus|evm.model.CM009497.1.1178 Q2KIA0 MEF2C_BOVIN 86.925 0.9161 1 MEF2C - Myocyte-specific enhancer factor 2C - Bos taurus (Bovine) - MEF2C gene Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Indicus|evm.model.CM009497.1.1180 I6VSD2 TM147_CAPHI 66.500 0.988024 0.745536 TMEM147 - Transmembrane protein 147 - Capra hircus (Goat) - TMEM147 gene Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Together with SEC61 and TMCO1, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity. Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Indicus|evm.model.CM009497.1.1182 A5PJT0 MBLC2_BOVIN 99.642 0.992857 1.00358 MBLAC2 - Metallo-beta-lactamase domain-containing protein 2 - Bos taurus (Bovine) - MBLAC2 gene Indicus|evm.model.CM009497.1.1183 O15318 RPC7_HUMAN 90.583 0.991071 1.00448 POLR3G - DNA-directed RNA polymerase III subunit RPC7 - Homo sapiens (Human) - POLR3G gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:20154270). May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). Indicus|evm.model.CM009497.1.1184 Q7Z3D4 LYSM3_HUMAN 89.216 0.993485 1.00327 LYSMD3 - LysM and putative peptidoglycan-binding domain-containing protein 3 - Homo sapiens (Human) - LYSMD3 gene Essential for Golgi structural integrity. Indicus|evm.model.CM009497.1.1186 Q8WXG9 AGRV1_HUMAN 93.521 0.951613 0.0589914 ADGRV1 - Adhesion G-protein coupled receptor V1 precursor - Homo sapiens (Human) - ADGRV1 gene G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism. Indicus|evm.model.CM009497.1.1187 Q0VCA2 ARRD3_BOVIN 99.758 0.995181 1.00242 ARRDC3 - Arrestin domain-containing protein 3 - Bos taurus (Bovine) - ARRDC3 gene Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Indicus|evm.model.CM009497.1.1188 P62832 RL23_RAT 64.773 0.78481 0.564286 Rpl23 - 60S ribosomal protein L23 - Rattus norvegicus (Rat) - Rpl23 gene cytoplasm, cytosolic large ribosomal subunit, nucleolus, nucleoplasm, postsynaptic density, protein-containing complex, ribosome, large ribosomal subunit rRNA binding, structural constituent of ribosome, transcription coactivator binding Indicus|evm.model.CM009497.1.1190 Q90733 COT2_CHICK 96.460 0.832512 0.990244 NR2F2 - COUP transcription factor 2 - Gallus gallus (Chicken) - NR2F2 gene Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development. Indicus|evm.model.CM009497.1.1191 Q8WUF8 F172A_HUMAN 97.297 0.994609 0.891827 FAM172A - Cotranscriptional regulator FAM172A precursor - Homo sapiens (Human) - FAM172A gene Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity. Indicus|evm.model.CM009497.1.1192 Q8IV33 K0825_HUMAN 82.578 0.998436 1.00314 KIAA0825 - Uncharacterized protein KIAA0825 - Homo sapiens (Human) - KIAA0825 gene Indicus|evm.model.CM009497.1.1194 A6QR20 SLF1_BOVIN 96.019 0.998031 0.963033 SLF1 - SMC5-SMC6 complex localization factor protein 1 - Bos taurus (Bovine) - SLF1 gene Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions. Indicus|evm.model.CM009497.1.1195 Q6DN14 MCTP1_HUMAN 98.058 0.996124 0.516517 MCTP1 - Multiple C2 and transmembrane domain-containing protein 1 - Homo sapiens (Human) - MCTP1 gene Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. Indicus|evm.model.CM009497.1.1196 E9PV86 MCTP1_MOUSE 94.631 0.766839 0.202944 Mctp1 - Multiple C2 and transmembrane domain-containing protein 1 - Mus musculus (Mouse) - Mctp1 gene Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. Indicus|evm.model.CM009497.1.1197 Q6DN14 MCTP1_HUMAN 80.000 0.814286 0.14014 MCTP1 - Multiple C2 and transmembrane domain-containing protein 1 - Homo sapiens (Human) - MCTP1 gene Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. Indicus|evm.model.CM009497.1.1198 Q0II90 FA81B_BOVIN 99.517 0.995181 1.00242 FAM81B - Protein FAM81B - Bos taurus (Bovine) - FAM81B gene Indicus|evm.model.CM009497.1.1199 Q6PGP7 TTC37_HUMAN 92.199 0.998721 1 TTC37 - Tetratricopeptide repeat protein 37 - Homo sapiens (Human) - TTC37 gene Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Indicus|evm.model.CM009497.1.1200 Q148F3 ARSK_BOVIN 90.926 0.996024 0.931481 ARSK - Arylsulfatase K precursor - Bos taurus (Bovine) - ARSK gene Indicus|evm.model.CM009497.1.1201 O94955 RHBT3_HUMAN 95.581 0.846047 1.18003 RHOBTB3 - Rho-related BTB domain-containing protein 3 - Homo sapiens (Human) - RHOBTB3 gene Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. Indicus|evm.model.CM009497.1.1202 Q8NGU9 GP150_HUMAN 70.048 0.985646 0.481567 GPR150 - Probable G-protein coupled receptor 150 - Homo sapiens (Human) - GPR150 gene Orphan receptor. Indicus|evm.model.CM009497.1.1203 Q8TAC1 RFESD_HUMAN 85.987 0.981132 1.01274 RFESD - Rieske domain-containing protein - Homo sapiens (Human) - RFESD gene Indicus|evm.model.CM009497.1.1204 Q3T021 SPAT9_BOVIN 99.605 0.992126 1.00395 SPATA9 - Spermatogenesis-associated protein 9 - Bos taurus (Bovine) - SPATA9 gene May play at role in testicular development/spermatogenesis and may be an important factor in male infertility. Indicus|evm.model.CM009497.1.1206 P10575 GLRX1_BOVIN 100.000 0.777778 1.27358 GLRX - Glutaredoxin-1 - Bos taurus (Bovine) - GLRX gene Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Indicus|evm.model.CM009497.1.1207 O00472 ELL2_HUMAN 92.217 0.993255 0.926562 ELL2 - RNA polymerase II elongation factor ELL2 - Homo sapiens (Human) - ELL2 gene Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. Indicus|evm.model.CM009497.1.1208 Q9GLR1 NEC1_BOVIN 99.203 0.997347 1.00133 PCSK1 - Neuroendocrine convertase 1 precursor - Bos taurus (Bovine) - PCSK1 gene Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. Indicus|evm.model.CM009497.1.1209 P20811 ICAL_BOVIN 90.522 0.911055 1.11631 CAST - Calpastatin - Bos taurus (Bovine) - CAST gene Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. Indicus|evm.model.CM009497.1.1210 Q9NZ08 ERAP1_HUMAN 87.966 0.994698 1.00213 ERAP1 - Endoplasmic reticulum aminopeptidase 1 - Homo sapiens (Human) - ERAP1 gene Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Indicus|evm.model.CM009497.1.1211 A6QPT7 ERAP2_BOVIN 99.476 0.997906 1.00105 ERAP2 - Endoplasmic reticulum aminopeptidase 2 - Bos taurus (Bovine) - ERAP2 gene Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys (By similarity). Indicus|evm.model.CM009497.1.1212 Q9UIQ6 LCAP_HUMAN 86.647 0.998053 1.00195 LNPEP - Leucyl-cystinyl aminopeptidase - Homo sapiens (Human) - LNPEP gene Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Indicus|evm.model.CM009497.1.1213 F1N5S9 FUND1_BOVIN 82.581 0.987179 1.00645 FUNDC1 - FUN14 domain-containing protein 1 - Bos taurus (Bovine) - FUNDC1 gene Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Indicus|evm.model.CM009497.1.1215 Q8N485 LIX1_HUMAN 94.574 0.850993 1.07092 LIX1 - Protein limb expression 1 homolog - Homo sapiens (Human) - LIX1 gene cytoplasm, autophagosome maturation Indicus|evm.model.CM009497.1.1216 Q9BVS4 RIOK2_HUMAN 87.319 0.996377 1 RIOK2 - Serine/threonine-protein kinase RIO2 - Homo sapiens (Human) - RIOK2 gene Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). Indicus|evm.model.CM009497.1.1217 Q6NW40 RGMB_HUMAN 91.327 0.85 1.05263 RGMB - Repulsive guidance molecule B precursor - Homo sapiens (Human) - RGMB gene Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. Indicus|evm.model.CM009497.1.1218 O14646 CHD1_HUMAN 98.397 0.760556 1.05263 CHD1 - Chromodomain-helicase-DNA-binding protein 1 - Homo sapiens (Human) - CHD1 gene ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). Indicus|evm.model.CM009497.1.1219 P09645 TBA8_CHICK 61.538 0.950617 0.25 Tubulin alpha-8 chain - Gallus gallus (Chicken) Indicus|evm.model.CM009497.1.1220 Q8TBP5 F174A_HUMAN 98.592 0.972222 0.378947 FAM174A - Membrane protein FAM174A precursor - Homo sapiens (Human) - FAM174A gene Indicus|evm.model.CM009497.1.1221 Q6ZXC9 SIA8D_BOVIN 99.443 0.994444 1.00279 ST8SIA4 - CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase - Bos taurus (Bovine) - ST8SIA4 gene Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells. Indicus|evm.model.CM009497.1.1222 Q71MB6 SO4C1_RAT 74.069 0.997211 0.990331 Slco4c1 - Solute carrier organic anion transporter family member 4C1 - Rattus norvegicus (Rat) - Slco4c1 gene Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg. Indicus|evm.model.CM009497.1.1223 Q86UG4 SO6A1_HUMAN 59.281 0.247761 0.93185 SLCO6A1 - Solute carrier organic anion transporter family member 6A1 - Homo sapiens (Human) - SLCO6A1 gene integral component of plasma membrane, sodium-independent organic anion transmembrane transporter activity, sodium-independent organic anion transport Indicus|evm.model.CM009497.1.1226 P10731 AMD_BOVIN 99.794 0.997945 1.00103 PAM - Peptidyl-glycine alpha-amidating monooxygenase precursor - Bos taurus (Bovine) - PAM gene Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides (PubMed:2059626). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monoxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate (PubMed:2059626). The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate (PubMed:2059626). Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (By similarity). Indicus|evm.model.CM009497.1.1227 Q4R5M0 RL5_MACFA 69.149 0.978723 0.316498 RPL5 - 60S ribosomal protein L5 - Macaca fascicularis (Crab-eating macaque) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Indicus|evm.model.CM009497.1.1228 A4FUB7 GIN1_BOVIN 95.585 0.996169 1.04609 GIN1 - Gypsy retrotransposon integrase-like protein 1 - Bos taurus (Bovine) - GIN1 gene Indicus|evm.model.CM009497.1.1229 O43314 VIP2_HUMAN 92.277 0.993289 0.95897 PPIP5K2 - Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 - Homo sapiens (Human) - PPIP5K2 gene Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). Indicus|evm.model.CM009497.1.1231 Q3ZBS1 MACIR_BOVIN 100.000 0.990385 1.00483 MACIR - Macrophage immunometabolism regulator - Bos taurus (Bovine) - MACIR gene Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis. May play also a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells. Indicus|evm.model.CM009497.1.1236 Q29RH3 NUD12_BOVIN 95.887 0.99568 1.04279 NUDT12 - NAD-capped RNA hydrolase NUDT12 - Bos taurus (Bovine) - NUDT12 gene mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress (By similarity). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). Indicus|evm.model.CM009497.1.1238 Q9WV69 DEMA_MOUSE 66.667 0.584906 0.261728 Dmtn - Dematin - Mus musculus (Mouse) - Dmtn gene Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. Indicus|evm.model.CM009497.1.1239 P02722 ADT1_BOVIN 97.942 0.834483 0.973154 SLC25A4 - ADP/ATP translocase 1 - Bos taurus (Bovine) - SLC25A4 gene ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (PubMed:7961643). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (PubMed:7961643). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). Indicus|evm.model.CM009497.1.1241 P62630 EF1A1_RAT 81.295 0.89404 0.32684 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009497.1.1242 P68105 EF1A1_RABIT 75.449 0.972028 0.309524 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009497.1.1243 Q9Y520 PRC2C_HUMAN 94.318 0.769912 0.0390193 PRRC2C - Protein PRRC2C - Homo sapiens (Human) - PRRC2C gene Required for efficient formation of stress granules. Indicus|evm.model.CM009497.1.1247 P52803 EFNA5_HUMAN 100.000 0.986577 0.653509 EFNA5 - Ephrin-A5 precursor - Homo sapiens (Human) - EFNA5 gene Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. Indicus|evm.model.CM009497.1.1250 Q9UF56 FXL17_HUMAN 98.773 0.987805 0.233951 FBXL17 - F-box/LRR-repeat protein 17 - Homo sapiens (Human) - FBXL17 gene Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity). Indicus|evm.model.CM009497.1.1254 O43164 PJA2_HUMAN 84.592 0.996979 0.935028 PJA2 - E3 ubiquitin-protein ligase Praja-2 - Homo sapiens (Human) - PJA2 gene Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Indicus|evm.model.CM009497.1.1255 A8D8X1 RL10_SHEEP 46.667 0.98 0.46729 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009497.1.1256 Q16706 MA2A1_HUMAN 95.652 0.182927 0.215035 MAN2A1 - Alpha-mannosidase 2 - Homo sapiens (Human) - MAN2A1 gene Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Indicus|evm.model.CM009497.1.1257 P27046 MA2A1_MOUSE 81.603 0.546361 0.872174 Man2a1 - Alpha-mannosidase 2 - Mus musculus (Mouse) - Man2a1 gene Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Indicus|evm.model.CM009497.1.1260 C9JQI7 TM232_HUMAN 71.168 0.989264 0.99239 TMEM232 - Transmembrane protein 232 - Homo sapiens (Human) - TMEM232 gene Indicus|evm.model.CM009497.1.1261 Q96AG3 S2546_HUMAN 86.571 0.992754 0.990431 SLC25A46 - Solute carrier family 25 member 46 - Homo sapiens (Human) - SLC25A46 gene May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission. Indicus|evm.model.CM009497.1.1262 O77737 B2CL1_PIG 70.000 0.988889 0.386266 BCL2L1 - Bcl-2-like protein 1 - Sus scrofa (Pig) - BCL2L1 gene Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). Indicus|evm.model.CM009498.1.1 A4IF94 MF14B_BOVIN 100.000 0.996024 1.00199 MFSD14B - Hippocampus abundant transcript-like protein 1 - Bos taurus (Bovine) - MFSD14B gene Indicus|evm.model.CM009498.1.2 Q9UJ72 ANX10_HUMAN 83.333 0.95102 0.756173 ANXA10 - Annexin A10 - Homo sapiens (Human) - ANXA10 gene cytoplasm, calcium ion binding Indicus|evm.model.CM009498.1.3 Q8IY21 DDX60_HUMAN 65.926 0.984375 0.0747664 DDX60 - Probable ATP-dependent RNA helicase DDX60 - Homo sapiens (Human) - DDX60 gene Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). Indicus|evm.model.CM009498.1.4 Q9QZ10 ANX10_MOUSE 95.238 0.72093 0.265432 Anxa10 - Annexin A10 - Mus musculus (Mouse) - Anxa10 gene cytoplasm, mitochondrion, calcium ion binding Indicus|evm.model.CM009498.1.5 Q8WX93 PALLD_HUMAN 61.231 0.993846 0.234996 PALLD - Palladin - Homo sapiens (Human) - PALLD gene Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. Indicus|evm.model.CM009498.1.7 Q8WX93 PALLD_HUMAN 75.211 0.569767 0.435286 PALLD - Palladin - Homo sapiens (Human) - PALLD gene Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. Indicus|evm.model.CM009498.1.9 P0C5E3 PALLD_RAT 85.928 0.818342 0.940299 Palld - Palladin - Rattus norvegicus (Rat) - Palld gene Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Plays a role in neurite outgrowth and in the establishment of polarity during neuronal morphogenesis. Participates in the acquisition of the reactive astrocyte morphology. Indicus|evm.model.CM009498.1.10 A4IFA7 CBR4_BOVIN 99.156 0.991597 1.00422 CBR4 - 3-oxoacyl-[acyl-carrier-protein] reductase - Bos taurus (Bovine) - CBR4 gene Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). Indicus|evm.model.CM009498.1.12 A5D7F8 SH3R1_BOVIN 99.577 0.976552 0.863095 SH3RF1 - E3 ubiquitin-protein ligase SH3RF1 - Bos taurus (Bovine) - SH3RF1 gene Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly. Indicus|evm.model.CM009498.1.13 A5D7F8 SH3R1_BOVIN 100.000 0.807453 0.191667 SH3RF1 - E3 ubiquitin-protein ligase SH3RF1 - Bos taurus (Bovine) - SH3RF1 gene Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly. Indicus|evm.model.CM009498.1.14 Q96PY6 NEK1_HUMAN 79.099 0.998387 0.985692 NEK1 - Serine/threonine-protein kinase Nek1 - Homo sapiens (Human) - NEK1 gene Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). Indicus|evm.model.CM009498.1.15 O18894 CLCN3_RABIT 98.533 0.997558 1.00122 CLCN3 - H(+)/Cl(-) exchange transporter 3 - Oryctolagus cuniculus (Rabbit) - CLCN3 gene Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). Indicus|evm.model.CM009498.1.16 A2VDY4 HPF1_BOVIN 99.133 0.994236 1.00289 HPF1 - Histone PARylation factor 1 - Bos taurus (Bovine) - HPF1 gene Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response. Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by PARP1 and PARP2 and switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins. Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 acts by completing the active site of PARP1 and PARP2: forms a composite active site composed of residues from HPF1 and PARP1 or PARP2. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1. Indicus|evm.model.CM009498.1.17 Q0P5N5 GRPE2_BOVIN 84.021 0.955446 0.901786 GRPEL2 - GrpE protein homolog 2, mitochondrial precursor - Bos taurus (Bovine) - GRPEL2 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). Indicus|evm.model.CM009498.1.18 O75121 MFA3L_HUMAN 78.935 0.995025 0.982885 MFAP3L - Microfibrillar-associated protein 3-like precursor - Homo sapiens (Human) - MFAP3L gene May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. Indicus|evm.model.CM009498.1.20 Q5E9N4 AADAT_BOVIN 99.764 0.995294 1 AADAT - Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - AADAT gene Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). Indicus|evm.model.CM009498.1.21 Q5E9N4 AADAT_BOVIN 89.688 0.8125 1.20471 AADAT - Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - AADAT gene Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). Indicus|evm.model.CM009498.1.24 Q49A17 GLTL6_HUMAN 99.194 0.953488 0.214642 GALNTL6 - Polypeptide N-acetylgalactosaminyltransferase-like 6 - Homo sapiens (Human) - GALNTL6 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Indicus|evm.model.CM009498.1.25 Q49A17 GLTL6_HUMAN 93.878 0.917293 0.442596 GALNTL6 - Polypeptide N-acetylgalactosaminyltransferase-like 6 - Homo sapiens (Human) - GALNTL6 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Indicus|evm.model.CM009498.1.26 Q5RFJ6 GALT7_PONAB 92.370 0.884892 1.05784 GALNT7 - N-acetylgalactosaminyltransferase 7 - Pongo abelii (Sumatran orangutan) - GALNT7 gene Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified (By similarity). Indicus|evm.model.CM009498.1.27 P26583 HMGB2_HUMAN 100.000 0.990476 1.00478 HMGB2 - High mobility group protein B2 - Homo sapiens (Human) - HMGB2 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). Indicus|evm.model.CM009498.1.28 O88574 SAP30_MOUSE 96.795 0.745192 0.945455 Sap30 - Histone deacetylase complex subunit SAP30 - Mus musculus (Mouse) - Sap30 gene Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. Indicus|evm.model.CM009498.1.29 P61295 HAND2_RAT 99.394 0.987952 0.764977 Hand2 - Heart- and neural crest derivatives-expressed protein 2 - Rattus norvegicus (Rat) - Hand2 gene Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Indicus|evm.model.CM009498.1.31 Q5E9G6 FBX8_BOVIN 100.000 0.99375 1.00313 FBXO8 - F-box only protein 8 - Bos taurus (Bovine) - FBXO8 gene May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential). Indicus|evm.model.CM009498.1.32 Q08DB0 CEP44_BOVIN 99.721 0.862651 1.07792 CEP44 - Centrosomal protein of 44 kDa - Bos taurus (Bovine) - CEP44 gene Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome. Indicus|evm.model.CM009498.1.33 Q3T0C2 PGDH_BOVIN 99.624 0.992509 1.00376 HPGD - 15-hydroxyprostaglandin dehydrogenase [NAD(+)] - Bos taurus (Bovine) - HPGD gene Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites. Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Converts 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE). Has hydroxylated docosahexaenoic acid metabolites as substrates. Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions. Indicus|evm.model.CM009498.1.34 O75311 GLRA3_HUMAN 95.556 0.283439 0.676724 GLRA3 - Glycine receptor subunit alpha-3 precursor - Homo sapiens (Human) - GLRA3 gene Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity). Indicus|evm.model.CM009498.1.35 Q9UKF5 ADA29_HUMAN 64.486 0.412674 1.57805 ADAM29 - Disintegrin and metalloproteinase domain-containing protein 29 precursor - Homo sapiens (Human) - ADAM29 gene May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein. Indicus|evm.model.CM009498.1.36 O43506 ADA20_HUMAN 56.044 0.986245 1.00138 ADAM20 - Disintegrin and metalloproteinase domain-containing protein 20 precursor - Homo sapiens (Human) - ADAM20 gene May be involved in sperm maturation and/or fertilization. Indicus|evm.model.CM009498.1.37 Q9UKF5 ADA29_HUMAN 51.729 0.876984 0.921951 ADAM29 - Disintegrin and metalloproteinase domain-containing protein 29 precursor - Homo sapiens (Human) - ADAM29 gene May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein. Indicus|evm.model.CM009498.1.38 O43506 ADA20_HUMAN 51.023 0.891361 1.05234 ADAM20 - Disintegrin and metalloproteinase domain-containing protein 20 precursor - Homo sapiens (Human) - ADAM20 gene May be involved in sperm maturation and/or fertilization. Indicus|evm.model.CM009498.1.40 P07688 CATB_BOVIN 100.000 0.994048 1.00299 CTSB - Cathepsin B precursor - Bos taurus (Bovine) - CTSB gene Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:1856234). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Indicus|evm.model.CM009498.1.41 Q32KR6 FDFT_BOVIN 99.760 0.995215 1.0024 FDFT1 - Squalene synthase - Bos taurus (Bovine) - FDFT1 gene Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Indicus|evm.model.CM009498.1.42 Q6IE77 NEIL2_BOVIN 100.000 0.428758 2.32523 NEIL2 - Endonuclease 8-like 2 - Bos taurus (Bovine) - NEIL2 gene Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity). Indicus|evm.model.CM009498.1.43 P51451 BLK_HUMAN 87.154 0.996016 0.994059 BLK - Tyrosine-protein kinase Blk - Homo sapiens (Human) - BLK gene Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214). Indicus|evm.model.CM009498.1.44 Q0V7M8 F167A_BOVIN 99.526 0.990566 1.00474 FAM167A - Protein FAM167A - Bos taurus (Bovine) - FAM167A gene Indicus|evm.model.CM009498.1.45 Q2KIR8 TDH_BOVIN 100.000 0.946565 1.05362 TDH - L-threonine 3-dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - TDH gene Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism. Indicus|evm.model.CM009498.1.46 A7MB43 MTMR9_BOVIN 99.818 0.996364 1.00182 MTMR9 - Myotubularin-related protein 9 - Bos taurus (Bovine) - MTMR9 gene Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles. Negatively regulates autophagy, in part via its association with MTMR8. Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6. Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (By similarity). Indicus|evm.model.CM009498.1.47 Q5GH57 XKR6_RAT 96.419 0.942029 0.648903 Xkr6 - XK-related protein 6 - Rattus norvegicus (Rat) - Xkr6 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Indicus|evm.model.CM009498.1.48 Q5GH57 XKR6_RAT 89.941 0.836842 0.297806 Xkr6 - XK-related protein 6 - Rattus norvegicus (Rat) - Xkr6 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Indicus|evm.model.CM009498.1.49 Q96BK5 PINX1_HUMAN 96.183 0.507812 0.780488 PINX1 - PIN2/TERF1-interacting telomerase inhibitor 1 - Homo sapiens (Human) - PINX1 gene Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. Indicus|evm.model.CM009498.1.51 Q9BT81 SOX7_HUMAN 96.124 0.558952 0.590206 SOX7 - Transcription factor SOX-7 - Homo sapiens (Human) - SOX7 gene Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. Indicus|evm.model.CM009498.1.52 Q2NL11 CH074_BOVIN 87.202 0.994065 1.15017 Uncharacterized protein C8orf74 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009498.1.53 Q8IWN7 RP1L1_HUMAN 48.185 0.761762 0.974167 RP1L1 - Retinitis pigmentosa 1-like 1 protein - Homo sapiens (Human) - RP1L1 gene Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity). Indicus|evm.model.CM009498.1.54 Q6UWB4 PRS55_HUMAN 62.696 0.974603 0.894886 PRSS55 - Serine protease 55 precursor - Homo sapiens (Human) - PRSS55 gene Probable serine protease, which plays a crucial role in the fertility of male mice including sperm migration and sperm-egg interaction. Indicus|evm.model.CM009498.1.55 A0A1B0GVH4 PRS51_HUMAN 50.901 0.827715 1.21364 PRSS51 - Serine protease-like protein 51 precursor - Homo sapiens (Human) - PRSS51 gene Indicus|evm.model.CM009498.1.56 Q9D9M0 PRS52_MOUSE 55.731 0.915751 0.850467 Prss52 - Serine protease 52 precursor - Mus musculus (Mouse) - Prss52 gene Probable serine protease. Indicus|evm.model.CM009498.1.57 P54149 MSRA_BOVIN 100.000 0.991453 1.00429 MSRA - Mitochondrial peptide methionine sulfoxide reductase precursor - Bos taurus (Bovine) - MSRA gene Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Indicus|evm.model.CM009498.1.58 Q642A5 DPOE3_RAT 85.714 0.676056 0.489655 Pole3 - DNA polymerase epsilon subunit 3 - Rattus norvegicus (Rat) - Pole3 gene Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). Indicus|evm.model.CM009498.1.59 Q9NQT8 KI13B_HUMAN 86.582 0.942914 1.09365 KIF13B - Kinesin-like protein KIF13B - Homo sapiens (Human) - KIF13B gene Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. Indicus|evm.model.CM009498.1.61 Q6NT76 HMBX1_HUMAN 100.000 0.995249 1.00238 HMBOX1 - Homeobox-containing protein 1 - Homo sapiens (Human) - HMBOX1 gene Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958). Indicus|evm.model.CM009498.1.62 Q2KJA6 INT9_BOVIN 99.695 0.958944 1.03647 INTS9 - Integrator complex subunit 9 - Bos taurus (Bovine) - INTS9 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Indicus|evm.model.CM009498.1.63 O43909 EXTL3_HUMAN 96.953 0.997826 1.00109 EXTL3 - Exostosin-like 3 - Homo sapiens (Human) - EXTL3 gene Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) (PubMed:28132690, PubMed:28148688). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (PubMed:22727489). Indicus|evm.model.CM009498.1.65 Q61086 FZD3_MOUSE 98.498 0.997001 1.0015 Fzd3 - Frizzled-3 precursor - Mus musculus (Mouse) - Fzd3 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner. Indicus|evm.model.CM009498.1.66 Q8IX29 FBX16_HUMAN 87.986 0.826979 1.16781 FBXO16 - F-box only protein 16 - Homo sapiens (Human) - FBXO16 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Indicus|evm.model.CM009498.1.67 Q9H8N7 ZN395_HUMAN 84.139 0.996016 0.978558 ZNF395 - Zinc finger protein 395 - Homo sapiens (Human) - ZNF395 gene Plays a role in papillomavirus genes transcription. Indicus|evm.model.CM009498.1.68 O62647 PNOC_BOVIN 100.000 0.988701 1.00568 PNOC - Prepronociceptin precursor - Bos taurus (Bovine) - PNOC gene Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Indicus|evm.model.CM009498.1.69 Q4R5P3 RL10A_MACFA 54.167 0.975 0.368664 RPL10A - 60S ribosomal protein L10a - Macaca fascicularis (Crab-eating macaque) - RPL10A gene Component of the large ribosomal subunit. Indicus|evm.model.CM009498.1.70 Q2KJ61 ELP3_BOVIN 100.000 0.99635 1.00183 ELP3 - Elongator complex protein 3 - Bos taurus (Bovine) - ELP3 gene Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). Indicus|evm.model.CM009498.1.71 Q68CJ6 SLIP_HUMAN 85.031 0.997487 1 NUGGC - Nuclear GTPase SLIP-GC - Homo sapiens (Human) - NUGGC gene Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity). Indicus|evm.model.CM009498.1.72 A5PJQ2 SCAR5_BOVIN 100.000 0.94636 1.05455 SCARA5 - Scavenger receptor class A member 5 - Bos taurus (Bovine) - SCARA5 gene Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1). Indicus|evm.model.CM009498.1.73 Q96KB5 TOPK_HUMAN 89.164 0.990769 1.00932 PBK - Lymphokine-activated killer T-cell-originated protein kinase - Homo sapiens (Human) - PBK gene Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Indicus|evm.model.CM009498.1.74 Q56NI9 ESCO2_HUMAN 79.792 0.995816 0.795341 ESCO2 - N-acetyltransferase ESCO2 - Homo sapiens (Human) - ESCO2 gene Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). Indicus|evm.model.CM009498.1.75 Q3SZX8 CCD25_BOVIN 100.000 0.793103 1.25481 CCDC25 - Coiled-coil domain-containing protein 25 - Bos taurus (Bovine) - CCDC25 gene Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility. NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells. Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells. Indicus|evm.model.CM009498.1.76 Q6AZY7 SCAR3_HUMAN 89.212 0.925397 1.0396 SCARA3 - Scavenger receptor class A member 3 - Homo sapiens (Human) - SCARA3 gene Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation. Indicus|evm.model.CM009498.1.77 P17697 CLUS_BOVIN 99.544 0.995444 1 CLU - Clusterin precursor - Bos taurus (Bovine) - CLU gene Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). Indicus|evm.model.CM009498.1.78 Q5R4K6 PKHB2_PONAB 89.640 0.990991 1 PLEKHB2 - Pleckstrin homology domain-containing family B member 2 - Pongo abelii (Sumatran orangutan) - PLEKHB2 gene Involved in retrograde transport of recycling endosomes. Indicus|evm.model.CM009498.1.79 A7MB05 TM215_BOVIN 100.000 0.991525 1.00426 TMEM215 - Transmembrane protein 215 - Bos taurus (Bovine) - TMEM215 gene Indicus|evm.model.CM009498.1.80 Q02367 NDUB6_BOVIN 100.000 0.984496 1.00781 NDUFB6 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 - Bos taurus (Bovine) - NDUFB6 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009498.1.81 Q9NS56 TOPRS_HUMAN 90.067 0.998073 0.993301 TOPORS - E3 ubiquitin-protein ligase Topors - Homo sapiens (Human) - TOPORS gene Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. Indicus|evm.model.CM009498.1.82 Q9GLV6 DDX58_PIG 82.942 0.993637 1.00319 DDX58 - Antiviral innate immune response receptor RIG-I - Sus scrofa (Pig) - DDX58 gene Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons. Ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA ( Indicus|evm.model.CM009498.1.83 Q0VCU1 ACOC_BOVIN 100.000 0.986667 1.01237 ACO1 - Cytoplasmic aconitate hydratase - Bos taurus (Bovine) - ACO1 gene Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Indicus|evm.model.CM009498.1.87 Q56JZ7 ZCRB1_BOVIN 98.618 0.990826 1.00461 ZCRB1 - Zinc finger CCHC-type and RNA-binding motif-containing protein 1 - Bos taurus (Bovine) - ZCRB1 gene U12-type spliceosomal complex, mRNA splicing, via spliceosome Indicus|evm.model.CM009498.1.88 Q7L985 LIGO2_HUMAN 98.845 0.996705 1.00165 LINGO2 - Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor - Homo sapiens (Human) - LINGO2 gene extracellular matrix, extracellular space Indicus|evm.model.CM009498.1.89 Q96LT7 CI072_HUMAN 98.753 0.995851 1.00208 C9orf72 - Guanine nucleotide exchange C9orf72 - Homo sapiens (Human) - C9orf72 gene Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity (PubMed:27617292). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ATG1/ULK1 kinase complex to the phagophore which leads to autophagosome formation (PubMed:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131). Plays a role in endosomal trafficking (PubMed:24549040). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity). Indicus|evm.model.CM009498.1.90 Q9P0W0 IFNK_HUMAN 65.116 0.963964 1.07246 IFNK - Interferon kappa precursor - Homo sapiens (Human) - IFNK gene May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. Indicus|evm.model.CM009498.1.91 Q29RK9 MOB3B_BOVIN 100.000 0.967136 0.986111 MOB3B - MOB kinase activator 3B - Bos taurus (Bovine) - MOB3B gene Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Indicus|evm.model.CM009498.1.92 Q9NQ60 EQTN_HUMAN 51.524 0.947531 1.10204 EQTN - Equatorin precursor - Homo sapiens (Human) - EQTN gene Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. Indicus|evm.model.CM009498.1.94 P0C843 CI014_HUMAN 59.574 0.1875 4.91089 LINC00032 - Putative uncharacterized protein encoded by LINC00032 - Homo sapiens (Human) - LINC00032 gene Indicus|evm.model.CM009498.1.95 Q06807 TIE2_BOVIN 99.911 0.998224 1.00089 TEK - Angiopoietin-1 receptor precursor - Bos taurus (Bovine) - TEK gene Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1, SHC1 and TIE1 (By similarity). Indicus|evm.model.CM009498.1.96 Q8BKE9 IFT74_MOUSE 91.833 0.996672 1.00167 Ift74 - Intraflagellar transport protein 74 homolog - Mus musculus (Mouse) - Ift74 gene Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis (By similarity). Indicus|evm.model.CM009498.1.97 Q9Y263 PLAP_HUMAN 93.719 0.997491 1.00252 PLAA - Phospholipase A-2-activating protein - Homo sapiens (Human) - PLAA gene Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). Indicus|evm.model.CM009498.1.98 Q2T9W9 CAAP1_BOVIN 100.000 0.99449 1.00276 CAAP1 - Caspase activity and apoptosis inhibitor 1 - Bos taurus (Bovine) - CAAP1 gene Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. Indicus|evm.model.CM009498.1.99 O18882 VATL_SHEEP 98.561 0.985714 0.903226 ATP6V0C - V-type proton ATPase 16 kDa proteolipid subunit - Ovis aries (Sheep) - ATP6V0C gene Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Indicus|evm.model.CM009498.1.101 Q99877 H2B1N_HUMAN 93.671 0.962963 0.642857 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009498.1.102 Q2TAM9 TUSC1_HUMAN 74.408 0.985714 0.990566 TUSC1 - Tumor suppressor candidate gene 1 protein - Homo sapiens (Human) - TUSC1 gene Indicus|evm.model.CM009498.1.103 A6QL94 IZUM3_BOVIN 100.000 0.991701 1.00417 IZUMO3 - Izumo sperm-egg fusion protein 3 precursor - Bos taurus (Bovine) - IZUMO3 gene protein homodimerization activity Indicus|evm.model.CM009498.1.105 Q5R9Z6 ELAV2_PONAB 100.000 0.864734 1.1532 ELAVL2 - ELAV-like protein 2 - Pongo abelii (Sumatran orangutan) - ELAVL2 gene RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity). Indicus|evm.model.CM009498.1.109 Q5VZB9 DMRTA_HUMAN 78.330 0.993964 0.986111 DMRTA1 - Doublesex- and mab-3-related transcription factor A1 - Homo sapiens (Human) - DMRTA1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, germ cell development, regulation of transcription by RNA polymerase II, sex differentiation Indicus|evm.model.CM009498.1.110 Q3SZV3 EF1G_BOVIN 93.434 0.994723 0.861364 EEF1G - Elongation factor 1-gamma - Bos taurus (Bovine) - EEF1G gene Probably plays a role in anchoring the complex to other cellular components. Indicus|evm.model.CM009498.1.111 Q2KJD8 CDN2B_BOVIN 99.237 0.984848 1.00763 CDKN2B - Cyclin-dependent kinase 4 inhibitor B - Bos taurus (Bovine) - CDKN2B gene Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity). Indicus|evm.model.CM009498.1.113 Q2KJD8 CDN2B_BOVIN 83.471 0.784314 1.16794 CDKN2B - Cyclin-dependent kinase 4 inhibitor B - Bos taurus (Bovine) - CDKN2B gene Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity). Indicus|evm.model.CM009498.1.114 Q3MHF7 MTAP_BOVIN 100.000 0.992958 1.00353 MTAP - S-methyl-5'-thioadenosine phosphorylase - Bos taurus (Bovine) - MTAP gene Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Indicus|evm.model.CM009498.1.115 A7UHZ5 IFNE_PIG 85.938 0.984536 1.00518 IFNE - Interferon epsilon precursor - Sus scrofa (Pig) - IFNE gene Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity). Indicus|evm.model.CM009498.1.116 P15696 IFNT1_BOVIN 100.000 0.304813 0.958974 IFNT1 - Interferon tau-1 precursor - Bos taurus (Bovine) - IFNT1 gene Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible. Indicus|evm.model.CM009498.1.117 Q08053 IFNTA_SHEEP 90.909 0.581081 0.379487 IFNT10 - Interferon tau-10 precursor - Ovis aries (Sheep) - IFNT10 gene Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible. Indicus|evm.model.CM009498.1.118 P15696 IFNT1_BOVIN 97.423 0.984694 1.00513 IFNT1 - Interferon tau-1 precursor - Bos taurus (Bovine) - IFNT1 gene Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible. Indicus|evm.model.CM009498.1.119 P05008 IFNAB_BOVIN 72.269 0.978495 0.492063 IFNAB - Interferon alpha-B precursor - Bos taurus (Bovine) - IFNAB gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Indicus|evm.model.CM009498.1.120 P05002 IFNW2_HORSE 50.562 0.280576 1.42564 Interferon omega-2 precursor - Equus caballus (Horse) Indicus|evm.model.CM009498.1.121 P07348 IFNA1_BOVIN 92.593 0.944724 1.05291 Interferon alpha-1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009498.1.122 P07352 IFNW1_BOVIN 89.231 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.123 P07352 IFNW1_BOVIN 90.256 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.124 P07352 IFNW1_BOVIN 88.718 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.125 P49876 IFNAF_BOVIN 97.884 0.989474 1.00529 IFNAF - Interferon alpha-F precursor - Bos taurus (Bovine) - IFNAF gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Indicus|evm.model.CM009498.1.127 P07352 IFNW1_BOVIN 87.179 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.128 P07352 IFNW1_BOVIN 90.270 0.872038 1.08205 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.129 P07348 IFNA1_BOVIN 99.471 0.989474 1.00529 Interferon alpha-1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009498.1.130 P07352 IFNW1_BOVIN 98.974 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.131 P07352 IFNW1_BOVIN 81.731 0.980952 0.538462 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.132 P07352 IFNW1_BOVIN 89.394 0.706522 0.471795 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.133 P05007 IFNAA_BOVIN 93.122 0.944724 1.05291 IFNAA - Interferon alpha-A precursor - Bos taurus (Bovine) - IFNAA gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Indicus|evm.model.CM009498.1.134 P07352 IFNW1_BOVIN 87.958 0.86758 1.12308 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.135 P07352 IFNW1_BOVIN 88.205 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.136 P05009 IFNAC_BOVIN 95.238 0.989474 1.00529 IFNAC - Interferon alpha-C precursor - Bos taurus (Bovine) - IFNAC gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Indicus|evm.model.CM009498.1.137 Q9P2J3 KLHL9_HUMAN 99.838 0.996764 1.00162 KLHL9 - Kelch-like protein 9 - Homo sapiens (Human) - KLHL9 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. Indicus|evm.model.CM009498.1.139 P49877 IFNAG_BOVIN 95.767 0.989474 1.00529 IFNAG - Interferon alpha-G precursor - Bos taurus (Bovine) - IFNAG gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Indicus|evm.model.CM009498.1.140 P07352 IFNW1_BOVIN 89.744 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.141 P07352 IFNW1_BOVIN 89.744 0.451163 2.20513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.142 P05009 IFNAC_BOVIN 98.413 0.989474 1.00529 IFNAC - Interferon alpha-C precursor - Bos taurus (Bovine) - IFNAC gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Indicus|evm.model.CM009498.1.143 P07352 IFNW1_BOVIN 88.205 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.144 P07352 IFNW1_BOVIN 89.744 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.146 P07352 IFNW1_BOVIN 79.348 0.875598 1.07179 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.147 P07352 IFNW1_BOVIN 88.718 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.148 P07352 IFNW1_BOVIN 90.576 0.979381 0.994872 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.149 P49878 IFNAH_BOVIN 93.750 0.338863 2.2328 IFNAH - Interferon alpha-H precursor - Bos taurus (Bovine) - IFNAH gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Indicus|evm.model.CM009498.1.150 P07352 IFNW1_BOVIN 89.231 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.151 P49878 IFNAH_BOVIN 96.296 0.944724 1.05291 IFNAH - Interferon alpha-H precursor - Bos taurus (Bovine) - IFNAH gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Indicus|evm.model.CM009498.1.152 P05001 IFNW1_HORSE 45.349 0.56 0.769231 Interferon omega-1 precursor - Equus caballus (Horse) Indicus|evm.model.CM009498.1.153 P49878 IFNAH_BOVIN 96.296 0.989474 1.00529 IFNAH - Interferon alpha-H precursor - Bos taurus (Bovine) - IFNAH gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Indicus|evm.model.CM009498.1.154 P07352 IFNW1_BOVIN 89.744 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.155 P07352 IFNW1_BOVIN 87.692 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.156 P07352 IFNW1_BOVIN 87.692 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.158 P07352 IFNW1_BOVIN 90.769 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.159 P05008 IFNAB_BOVIN 94.180 0.989474 1.00529 IFNAB - Interferon alpha-B precursor - Bos taurus (Bovine) - IFNAB gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Indicus|evm.model.CM009498.1.160 P07352 IFNW1_BOVIN 89.744 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.161 P01576 IFNB2_BOVIN 86.022 0.989305 1.00538 IFNB2 - Interferon beta-2 precursor - Bos taurus (Bovine) - IFNB2 gene Has antiviral, antibacterial and anticancer activities. Indicus|evm.model.CM009498.1.163 P01577 IFNB3_BOVIN 80.435 0.991342 1.24194 IFNB3 - Interferon beta-3 precursor - Bos taurus (Bovine) - IFNB3 gene Has antiviral, antibacterial and anticancer activities. Indicus|evm.model.CM009498.1.164 P01577 IFNB3_BOVIN 99.375 0.584559 1.46237 IFNB3 - Interferon beta-3 precursor - Bos taurus (Bovine) - IFNB3 gene Has antiviral, antibacterial and anticancer activities. Indicus|evm.model.CM009498.1.165 P01577 IFNB3_BOVIN 100.000 0.303191 1.01075 IFNB3 - Interferon beta-3 precursor - Bos taurus (Bovine) - IFNB3 gene Has antiviral, antibacterial and anticancer activities. Indicus|evm.model.CM009498.1.167 P07352 IFNW1_BOVIN 79.208 0.75188 0.682051 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.168 P05003 IFNA1_HORSE 50.413 0.983471 0.657609 Interferon alpha-1 precursor - Equus caballus (Horse) Indicus|evm.model.CM009498.1.169 P01578 IFNB1_BOVIN 97.312 0.989305 1.00538 IFNB1 - Interferon beta-1 precursor - Bos taurus (Bovine) - IFNB1 gene Has antiviral, antibacterial and anticancer activities. Indicus|evm.model.CM009498.1.170 O46633 IFNT_CEREL 87.097 0.417808 0.748718 IFNT - Interferon tau precursor - Cervus elaphus (Red deer) - IFNT gene Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible. Indicus|evm.model.CM009498.1.171 P05003 IFNA1_HORSE 52.066 0.983471 0.657609 Interferon alpha-1 precursor - Equus caballus (Horse) Indicus|evm.model.CM009498.1.172 P01578 IFNB1_BOVIN 89.503 0.841121 1.15054 IFNB1 - Interferon beta-1 precursor - Bos taurus (Bovine) - IFNB1 gene Has antiviral, antibacterial and anticancer activities. Indicus|evm.model.CM009498.1.173 P07352 IFNW1_BOVIN 72.034 0.745223 0.805128 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Indicus|evm.model.CM009498.1.174 P05005 IFNA3_HORSE 51.445 0.913978 1.01087 Interferon alpha-3 precursor - Equus caballus (Horse) Indicus|evm.model.CM009498.1.175 P01576 IFNB2_BOVIN 91.875 0.524752 1.62903 IFNB2 - Interferon beta-2 precursor - Bos taurus (Bovine) - IFNB2 gene Has antiviral, antibacterial and anticancer activities. Indicus|evm.model.CM009498.1.176 P05005 IFNA3_HORSE 48.062 0.845638 0.809783 Interferon alpha-3 precursor - Equus caballus (Horse) Indicus|evm.model.CM009498.1.177 P01576 IFNB2_BOVIN 97.484 0.583026 1.45699 IFNB2 - Interferon beta-2 precursor - Bos taurus (Bovine) - IFNB2 gene Has antiviral, antibacterial and anticancer activities. Indicus|evm.model.CM009498.1.178 P01576 IFNB2_BOVIN 94.624 0.989305 1.00538 IFNB2 - Interferon beta-2 precursor - Bos taurus (Bovine) - IFNB2 gene Has antiviral, antibacterial and anticancer activities. Indicus|evm.model.CM009498.1.179 Q0P5C7 HACD4_BOVIN 99.567 0.991379 1.00433 HACD4 - Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 - Bos taurus (Bovine) - HACD4 gene Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Indicus|evm.model.CM009498.1.180 Q5VW36 FOCAD_HUMAN 91.667 0.0336435 0.77568 FOCAD - Focadhesin - Homo sapiens (Human) - FOCAD gene Potential tumor suppressor in gliomas. Indicus|evm.model.CM009498.1.181 P42568 AF9_HUMAN 90.088 0.994197 0.910211 MLLT3 - Protein AF-9 - Homo sapiens (Human) - MLLT3 gene Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). Indicus|evm.model.CM009498.1.182 Q9UI40 NCKX2_HUMAN 89.608 0.996914 0.980333 SLC24A2 - Sodium/potassium/calcium exchanger 2 - Homo sapiens (Human) - SLC24A2 gene Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Indicus|evm.model.CM009498.1.183 Q5QJU3 ACER2_HUMAN 95.273 0.992754 1.00364 ACER2 - Alkaline ceramidase 2 - Homo sapiens (Human) - ACER2 gene Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates (PubMed:20089856). Also hydrolyzes dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990). As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage (PubMed:26943039, PubMed:28294157, PubMed:29229990). Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (PubMed:18945876). Indicus|evm.model.CM009498.1.184 Q5E995 RS6_BOVIN 99.510 0.611446 1.33333 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009498.1.185 Q5VZ89 DEN4C_HUMAN 88.974 0.889041 1.1472 DENND4C - DENN domain-containing protein 4C - Homo sapiens (Human) - DENND4C gene Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. Indicus|evm.model.CM009498.1.186 Q9TUM6 PLIN2_BOVIN 96.411 0.930804 0.995556 PLIN2 - Perilipin-2 - Bos taurus (Bovine) - PLIN2 gene May be involved in development and maintenance of adipose tissue. Indicus|evm.model.CM009498.1.187 Q7Z4H7 HAUS6_HUMAN 75.157 0.99791 1.00209 HAUS6 - HAUS augmin-like complex subunit 6 - Homo sapiens (Human) - HAUS6 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. Indicus|evm.model.CM009498.1.188 Q63486 RRAGA_RAT 100.000 0.993631 1.00319 Rraga - Ras-related GTP-binding protein A - Rattus norvegicus (Rat) - Rraga gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Indicus|evm.model.CM009498.1.189 Q8IYX7 SAXO1_HUMAN 81.818 0.987448 1.00844 SAXO1 - Stabilizer of axonemal microtubules 1 - Homo sapiens (Human) - SAXO1 gene May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature. Indicus|evm.model.CM009498.1.190 Q8N6G6 ATL1_HUMAN 79.035 0.998767 0.920545 ADAMTSL1 - ADAMTS-like protein 1 precursor - Homo sapiens (Human) - ADAMTSL1 gene endoplasmic reticulum lumen, extracellular matrix, metalloendopeptidase activity, extracellular matrix organization Indicus|evm.model.CM009498.1.191 O35179 SH3G2_RAT 97.947 0.909091 1.0625 Sh3gl2 - Endophilin-A1 - Rattus norvegicus (Rat) - Sh3gl2 gene Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (By similarity). Indicus|evm.model.CM009498.1.193 Q9NXG0 CNTLN_HUMAN 82.639 0.956522 0.638434 CNTLN - Centlein - Homo sapiens (Human) - CNTLN gene Required for centrosome cohesion and recruitment of CEP68 to centrosomes. Indicus|evm.model.CM009498.1.194 Q6ZN30 BNC2_HUMAN 97.917 0.909483 1.05551 BNC2 - Zinc finger protein basonuclin-2 - Homo sapiens (Human) - BNC2 gene Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115). Indicus|evm.model.CM009498.1.195 P16116 ALDR_BOVIN 99.500 0.633758 0.996825 AKR1B1 - Aldo-keto reductase family 1 member B1 - Bos taurus (Bovine) - AKR1B1 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Indicus|evm.model.CM009498.1.196 Q6TFL3 CC171_HUMAN 87.715 0.998451 0.973605 CCDC171 - Coiled-coil domain-containing protein 171 - Homo sapiens (Human) - CCDC171 gene Indicus|evm.model.CM009498.1.197 Q8MJG1 PSIP1_BOVIN 90.377 0.995833 0.90566 PSIP1 - PC4 and SFRS1-interacting protein - Bos taurus (Bovine) - PSIP1 gene Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity). Indicus|evm.model.CM009498.1.198 Q5E9M5 SNPC3_BOVIN 88.350 0.995098 0.990291 SNAPC3 - snRNA-activating protein complex subunit 3 - Bos taurus (Bovine) - SNAPC3 gene Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). Indicus|evm.model.CM009498.1.199 Q95LT8 TT39B_MACFA 89.134 0.952998 0.976266 TTC39B - Tetratricopeptide repeat protein 39B - Macaca fascicularis (Crab-eating macaque) - TTC39B gene Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3). Indicus|evm.model.CM009498.1.200 Q5H8C1 FREM1_HUMAN 83.928 0.97568 0.962368 FREM1 - FRAS1-related extracellular matrix protein 1 precursor - Homo sapiens (Human) - FREM1 gene Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development. Indicus|evm.model.CM009498.1.201 O95813 CER1_HUMAN 73.993 0.992701 1.02622 CER1 - Cerberus precursor - Homo sapiens (Human) - CER1 gene Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity). Indicus|evm.model.CM009498.1.202 A2VDT6 ZDH21_BOVIN 100.000 0.992481 1.00377 ZDHHC21 - Palmitoyltransferase ZDHHC21 - Bos taurus (Bovine) - ZDHHC21 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity). Indicus|evm.model.CM009498.1.203 Q99068 AMRP_RAT 76.398 0.879121 0.505556 Lrpap1 - Alpha-2-macroglobulin receptor-associated protein precursor - Rattus norvegicus (Rat) - Lrpap1 gene Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. Indicus|evm.model.CM009498.1.204 Q0VCL6 NFIB_BOVIN 100.000 0.364407 1.12381 NFIB - Nuclear factor 1 B-type - Bos taurus (Bovine) - NFIB gene Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Indicus|evm.model.CM009498.1.207 O75970 MPDZ_HUMAN 88.556 0.970855 1.01111 MPDZ - Multiple PDZ domain protein - Homo sapiens (Human) - MPDZ gene Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). Indicus|evm.model.CM009498.1.208 Q9DAW9 CNN3_MOUSE 84.211 0.986667 0.454545 Cnn3 - Calponin-3 - Mus musculus (Mouse) - Cnn3 gene Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). Indicus|evm.model.CM009498.1.209 Q8IV03 LUR1L_HUMAN 85.345 0.991189 0.982684 LURAP1L - Leucine rich adaptor protein 1-like - Homo sapiens (Human) - LURAP1L gene Indicus|evm.model.CM009498.1.210 Q8WN57 TYRP1_BOVIN 99.430 0.996205 0.981378 TYRP1 - 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor - Bos taurus (Bovine) - TYRP1 gene Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. Indicus|evm.model.CM009498.1.211 P67937 TPM4_PIG 89.516 0.991561 0.955645 TPM4 - Tropomyosin alpha-4 chain - Sus scrofa (Pig) - TPM4 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. Indicus|evm.model.CM009498.1.212 P39872 RL3_BOVIN 79.310 0.125561 0.55335 RPL3 - 60S ribosomal protein L3 - Bos taurus (Bovine) - RPL3 gene The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Indicus|evm.model.CM009498.1.213 Q3SZQ6 RL32_BOVIN 86.567 0.725275 0.674074 RPL32 - 60S ribosomal protein L32 - Bos taurus (Bovine) - RPL32 gene cytosolic large ribosomal subunit Indicus|evm.model.CM009498.1.214 A5PJP6 BRCC3_BOVIN 82.243 0.981308 0.338608 BRCC3 - Lys-63-specific deubiquitinase BRCC36 - Bos taurus (Bovine) - BRCC3 gene Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Indicus|evm.model.CM009498.1.215 Q2Q0J1 OOSP1_BOVIN 90.798 0.981818 1.01227 OOSP1 - Oocyte-secreted protein 1 precursor - Bos taurus (Bovine) - OOSP1 gene May be involved in cell differentiation. Indicus|evm.model.CM009498.1.217 Q8NHW5 RLA0L_HUMAN 87.324 0.958904 0.230284 RPLP0P6 - 60S acidic ribosomal protein P0-like - Homo sapiens (Human) - RPLP0P6 gene Ribosomal protein P0 is the functional equivalent of E.coli protein L10. Indicus|evm.model.CM009498.1.218 P23468 PTPRD_HUMAN 97.439 0.998943 0.98954 PTPRD - Receptor-type tyrosine-protein phosphatase delta precursor - Homo sapiens (Human) - PTPRD gene Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. Indicus|evm.model.CM009498.1.220 O15439 MRP4_HUMAN 77.922 0.987013 0.0581132 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009498.1.221 Q9H3R0 KDM4C_HUMAN 85.330 0.997301 0.701705 KDM4C - Lysine-specific demethylase 4C - Homo sapiens (Human) - KDM4C gene Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Indicus|evm.model.CM009498.1.222 Q8VCD7 KDM4C_MOUSE 96.040 0.60241 0.157495 Kdm4c - Lysine-specific demethylase 4C - Mus musculus (Mouse) - Kdm4c gene Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Indicus|evm.model.CM009498.1.223 Q9H3R0 KDM4C_HUMAN 95.833 0.489583 0.0909091 KDM4C - Lysine-specific demethylase 4C - Homo sapiens (Human) - KDM4C gene Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Indicus|evm.model.CM009498.1.224 O95372 LYPA2_HUMAN 90.000 0.987578 0.69697 LYPLA2 - Acyl-protein thioesterase 2 - Homo sapiens (Human) - LYPLA2 gene Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951). Indicus|evm.model.CM009498.1.225 P23378 GCSP_HUMAN 87.365 0.997932 0.948039 GLDC - Glycine dehydrogenase (decarboxylating), mitochondrial precursor - Homo sapiens (Human) - GLDC gene The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH). Indicus|evm.model.CM009498.1.226 Q96PU4 UHRF2_HUMAN 89.921 0.963291 0.985037 UHRF2 - E3 ubiquitin-protein ligase UHRF2 - Homo sapiens (Human) - UHRF2 gene E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131. Indicus|evm.model.CM009498.1.227 Q5R592 RPAB2_PONAB 98.425 0.984375 1.00787 POLR2F - DNA-directed RNA polymerases I, II, and III subunit RPABC2 - Pongo abelii (Sumatran orangutan) - POLR2F gene DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). Indicus|evm.model.CM009498.1.228 Q96J77 TPD55_HUMAN 77.206 0.553279 1.74286 TPD52L3 - Tumor protein D55 - Homo sapiens (Human) - TPD52L3 gene cytoplasm Indicus|evm.model.CM009498.1.229 O97863 IL33_CANLF 67.658 0.967153 1.04183 IL33 - Interleukin-33 precursor - Canis lupus familiaris (Dog) - IL33 gene Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Indicus|evm.model.CM009498.1.230 O60518 RNBP6_HUMAN 97.557 0.998192 1.0009 RANBP6 - Ran-binding protein 6 - Homo sapiens (Human) - RANBP6 gene May function in nuclear protein import as nuclear transport receptor. Indicus|evm.model.CM009498.1.231 Q5HYC2 K2026_HUMAN 85.592 0.999036 0.98621 KIAA2026 - Uncharacterized protein KIAA2026 - Homo sapiens (Human) - KIAA2026 gene Indicus|evm.model.CM009498.1.232 Q16655 MAR1_HUMAN 58.974 0.621849 1.00847 MLANA - Melanoma antigen recognized by T-cells 1 - Homo sapiens (Human) - MLANA gene Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. Indicus|evm.model.CM009498.1.233 Q7Z2K6 ERMP1_HUMAN 92.551 0.976543 0.896018 ERMP1 - Endoplasmic reticulum metallopeptidase 1 - Homo sapiens (Human) - ERMP1 gene Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. Indicus|evm.model.CM009498.1.234 Q4ADV7 RIC1_HUMAN 95.576 0.998595 1 RIC1 - Guanine nucleotide exchange factor subunit RIC1 - Homo sapiens (Human) - RIC1 gene The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). Indicus|evm.model.CM009498.1.235 Q9BQ51 PD1L2_HUMAN 69.884 0.905263 1.04396 PDCD1LG2 - Programmed cell death 1 ligand 2 precursor - Homo sapiens (Human) - PDCD1LG2 gene Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). Indicus|evm.model.CM009498.1.236 Q9NZQ7 PD1L1_HUMAN 73.196 0.993103 1 CD274 - Programmed cell death 1 ligand 1 precursor - Homo sapiens (Human) - CD274 gene Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Indicus|evm.model.CM009498.1.237 Q9HBL7 PLRKT_HUMAN 83.673 0.986486 1.0068 PLGRKT - Plasminogen receptor (KT) - Homo sapiens (Human) - PLGRKT gene Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9. Indicus|evm.model.CM009498.1.238 Q32L79 INSL6_BOVIN 99.512 0.990291 1.00488 INSL6 - Insulin-like peptide INSL6 precursor - Bos taurus (Bovine) - INSL6 gene May have a role in sperm development and fertilization. Indicus|evm.model.CM009498.1.239 O19064 JAK2_PIG 96.994 0.997352 1.00177 JAK2 - Tyrosine-protein kinase JAK2 - Sus scrofa (Pig) - JAK2 gene Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin. Indicus|evm.model.CM009498.1.240 Q2KHX8 RCL1_BOVIN 100.000 0.994652 1.00268 RCL1 - RNA 3'-terminal phosphate cyclase-like protein - Bos taurus (Bovine) - RCL1 gene Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity). Indicus|evm.model.CM009498.1.241 P08760 KAD3_BOVIN 100.000 0.991228 1.00441 AK3 - GTP:AMP phosphotransferase AK3, mitochondrial - Bos taurus (Bovine) - AK3 gene Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. Indicus|evm.model.CM009498.1.242 A6H754 CD37L_BOVIN 100.000 0.994083 1.00297 CDC37L1 - Hsp90 co-chaperone Cdc37-like 1 - Bos taurus (Bovine) - CDC37L1 gene Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. Indicus|evm.model.CM009498.1.243 Q5R7C4 SERF2_PONAB 98.305 0.966667 1.01695 SERF2 - Small EDRK-rich factor 2 - Pongo abelii (Sumatran orangutan) - SERF2 gene Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (By similarity). Indicus|evm.model.CM009498.1.244 Q58DI5 PLPP6_BOVIN 100.000 0.993103 1.00346 PLPP6 - Phospholipid phosphatase 6 - Bos taurus (Bovine) - PLPP6 gene Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid (By similarity). Indicus|evm.model.CM009498.1.245 Q8N4H0 SPA6L_HUMAN 74.101 0.836858 0.844388 SPATA6L - Spermatogenesis associated 6-like protein - Homo sapiens (Human) - SPATA6L gene Indicus|evm.model.CM009498.1.246 Q95135 EAA3_BOVIN 98.855 0.99619 1.00191 SLC1A1 - Excitatory amino acid transporter 3 - Bos taurus (Bovine) - SLC1A1 gene Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine (By similarity). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5 (By similarity). Indicus|evm.model.CM009498.1.249 Q8NEA6 GLIS3_HUMAN 88.703 0.966376 1.03613 GLIS3 - Zinc finger protein GLIS3 - Homo sapiens (Human) - GLIS3 gene Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). Indicus|evm.model.CM009498.1.250 Q8WY07 CTR3_HUMAN 53.055 0.383226 1.25202 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009498.1.251 Q4R3I8 RFX3_MACFA 99.437 0.939153 1.00935 RFX3 - Transcription factor RFX3 - Macaca fascicularis (Crab-eating macaque) - RFX3 gene Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (By similarity). Indicus|evm.model.CM009498.1.252 Q29B63 CARM1_DROPS 79.032 0.30198 0.380414 Art4 - Histone-arginine methyltransferase CARMER - Drosophila pseudoobscura pseudoobscura (Fruit fly) - Art4 gene Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in proteins. May methylate histone H3 at 'Arg-17' and activate transcription via chromatin remodeling (By similarity). Indicus|evm.model.CM009498.1.253 Q15397 PUM3_HUMAN 91.512 0.996914 1 PUM3 - Pumilio homolog 3 - Homo sapiens (Human) - PUM3 gene Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity). Indicus|evm.model.CM009498.1.254 Q8CFS6 KCNV2_MOUSE 82.270 0.991166 1.00712 Kcnv2 - Potassium voltage-gated channel subfamily V member 2 - Mus musculus (Mouse) - Kcnv2 gene Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity). Indicus|evm.model.CM009498.1.255 P98155 VLDLR_HUMAN 93.814 0.997636 0.969072 VLDLR - Very low-density lipoprotein receptor precursor - Homo sapiens (Human) - VLDLR gene Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). Indicus|evm.model.CM009498.1.256 O14490 DLGP1_HUMAN 82.311 0.995215 0.42784 DLGAP1 - Disks large-associated protein 1 - Homo sapiens (Human) - DLGAP1 gene Part of the postsynaptic scaffold in neuronal cells. Indicus|evm.model.CM009498.1.257 O14490 DLGP1_HUMAN 97.753 0.871287 0.103378 DLGAP1 - Disks large-associated protein 1 - Homo sapiens (Human) - DLGAP1 gene Part of the postsynaptic scaffold in neuronal cells. Indicus|evm.model.CM009498.1.258 P51531 SMCA2_HUMAN 98.859 0.178353 0.923899 SMARCA2 - Probable global transcription activator SNF2L2 - Homo sapiens (Human) - SMARCA2 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Indicus|evm.model.CM009498.1.260 Q9Y5R5 DMRT2_HUMAN 85.740 0.996422 0.996435 DMRT2 - Doublesex- and mab-3-related transcription factor 2 - Homo sapiens (Human) - DMRT2 gene Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity). Indicus|evm.model.CM009498.1.261 F6W2R2 DMRT3_HORSE 90.549 0.709328 0.972574 DMRT3 - Doublesex and mab-3 related transcription factor 3 - Equus caballus (Horse) - DMRT3 gene Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development. Indicus|evm.model.CM009498.1.262 C0LZJ1 DMRT1_BOVIN 89.655 0.390411 0.408964 DMRT1 - Doublesex and mab-3 related transcription factor 1 - Bos taurus (Bovine) - DMRT1 gene Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). Indicus|evm.model.CM009498.1.263 C0LZJ1 DMRT1_BOVIN 99.035 0.981013 0.885154 DMRT1 - Doublesex and mab-3 related transcription factor 1 - Bos taurus (Bovine) - DMRT1 gene Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). Indicus|evm.model.CM009498.1.264 Q14678 KANK1_HUMAN 88.807 0.998525 1.00296 KANK1 - KN motif and ankyrin repeat domain-containing protein 1 - Homo sapiens (Human) - KANK1 gene Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration (PubMed:25961457). Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1 (PubMed:25961457). Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways (PubMed:25961457). Indicus|evm.model.CM009498.1.265 Q8NF50 DOCK8_HUMAN 89.296 0.999006 0.958552 DOCK8 - Dedicator of cytokinesis protein 8 - Homo sapiens (Human) - DOCK8 gene Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). Indicus|evm.model.CM009498.1.266 Q8IUF1 CBWD2_HUMAN 88.161 0.992481 1.01013 CBWD2 - COBW domain-containing protein 2 - Homo sapiens (Human) - CBWD2 gene cytoplasm Indicus|evm.model.CM009498.1.267 Q63249 FOXD4_RAT 100.000 0.217391 4.55446 Foxd4 - Forkhead box protein D4 - Rattus norvegicus (Rat) - Foxd4 gene DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, anatomical structure morphogenesis, cell differentiation, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009498.1.268 Q8BZF8 PGM5_MOUSE 97.727 0.568627 0.269841 Pgm5 - Phosphoglucomutase-like protein 5 - Mus musculus (Mouse) - Pgm5 gene Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity (By similarity). Indicus|evm.model.CM009498.1.269 Q8BZF8 PGM5_MOUSE 98.333 0.922929 0.915344 Pgm5 - Phosphoglucomutase-like protein 5 - Mus musculus (Mouse) - Pgm5 gene Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity (By similarity). Indicus|evm.model.CM009498.1.270 Q8N6L7 TM252_HUMAN 66.082 0.988372 1.01176 TMEM252 - Transmembrane protein 252 - Homo sapiens (Human) - TMEM252 gene Indicus|evm.model.CM009498.1.271 Q96E09 PBIR1_HUMAN 97.909 0.866667 1.14983 PABIR1 - PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 - Homo sapiens (Human) - PABIR1 gene Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). Indicus|evm.model.CM009498.1.272 O14986 PI51B_HUMAN 96.667 0.996296 1 PIP5K1B - Phosphatidylinositol 4-phosphate 5-kinase type-1 beta - Homo sapiens (Human) - PIP5K1B gene Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Indicus|evm.model.CM009498.1.273 Q05B87 FRDA_BOVIN 100.000 0.990826 1.00461 FXN - Frataxin, mitochondrial precursor - Bos taurus (Bovine) - FXN gene Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). Indicus|evm.model.CM009498.1.274 Q95168 ZO2_CANLF 90.375 0.951947 1.02811 TJP2 - Tight junction protein ZO-2 - Canis lupus familiaris (Dog) - TJP2 gene Plays a role in tight junctions and adherens junctions. Indicus|evm.model.CM009498.1.275 Q15884 F1892_HUMAN 87.778 0.908907 1.09778 FAM189A2 - Protein FAM189A2 precursor - Homo sapiens (Human) - FAM189A2 gene Indicus|evm.model.CM009498.1.276 O35430 APBA1_RAT 82.938 0.997423 0.924911 Apba1 - Amyloid-beta A4 precursor protein-binding family A member 1 - Rattus norvegicus (Rat) - Apba1 gene Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Indicus|evm.model.CM009498.1.277 Q7Z6K3 PTAR1_HUMAN 86.713 0.995349 1.06965 PTAR1 - Protein prenyltransferase alpha subunit repeat-containing protein 1 - Homo sapiens (Human) - PTAR1 gene cytoplasm, protein prenylation Indicus|evm.model.CM009498.1.278 Q32L77 CI135_BOVIN 100.000 0.990783 0.935345 Protein C9orf135 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009498.1.279 Q7Z304 MAMC2_HUMAN 89.504 0.997089 1.00146 MAMDC2 - MAM domain-containing protein 2 precursor - Homo sapiens (Human) - MAMDC2 gene endoplasmic reticulum Indicus|evm.model.CM009498.1.280 Q8IY18 SMC5_HUMAN 92.566 0.997285 1.00363 SMC5 - Structural maintenance of chromosomes protein 5 - Homo sapiens (Human) - SMC5 gene Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). Indicus|evm.model.CM009498.1.281 P79288 KLF9_PIG 100.000 0.991837 1.0041 KLF9 - Krueppel-like factor 9 - Sus scrofa (Pig) - KLF9 gene Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation. Indicus|evm.model.CM009498.1.282 Q9HCF6 TRPM3_HUMAN 94.977 0.994767 0.993072 TRPM3 - Transient receptor potential cation channel subfamily M member 3 - Homo sapiens (Human) - TRPM3 gene Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. In addition, forms heteromultimeric ion channels with TRPM1 which are permeable for calcium and zinc ions (PubMed:21278253). Indicus|evm.model.CM009498.1.284 P19378 HSP7C_CRIGR 84.722 0.721649 0.150155 HSPA8 - Heat shock cognate 71 kDa protein - Cricetulus griseus (Chinese hamster) - HSPA8 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Interacts with VGF-derived peptide TLQP-21. Indicus|evm.model.CM009498.1.285 Q9UHN6 CEIP2_HUMAN 90.745 0.998555 1.00072 CEMIP2 - Cell surface hyaluronidase - Homo sapiens (Human) - CEMIP2 gene Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172). Indicus|evm.model.CM009498.1.286 Q5VST6 AB17B_HUMAN 100.000 0.99308 1.00347 ABHD17B - Alpha/beta hydrolase domain-containing protein 17B - Homo sapiens (Human) - ABHD17B gene Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913). Indicus|evm.model.CM009498.1.287 Q96MD7 CI085_HUMAN 95.455 0.698718 0.871508 C9orf85 - Uncharacterized protein C9orf85 - Homo sapiens (Human) - C9orf85 gene Indicus|evm.model.CM009498.1.290 Q9Y2T3 GUAD_HUMAN 90.088 0.995604 1.0022 GDA - Guanine deaminase - Homo sapiens (Human) - GDA gene Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Indicus|evm.model.CM009498.1.291 O76080 ZFAN5_HUMAN 98.592 0.902128 1.10329 ZFAND5 - AN1-type zinc finger protein 5 - Homo sapiens (Human) - ZFAND5 gene Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. Indicus|evm.model.CM009498.1.293 P68105 EF1A1_RABIT 94.762 0.963134 0.469697 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009498.1.294 A2Q0Z0 EF1A1_HORSE 95.536 0.917355 0.261905 EEF1A1 - Elongation factor 1-alpha 1 - Equus caballus (Horse) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009498.1.295 Q8R4P5 TMC1_MOUSE 92.744 0.957503 0.994716 Tmc1 - Transmembrane channel-like protein 1 - Mus musculus (Mouse) - Tmc1 gene Probable ion channel required for the normal function of cochlear hair cells. Indicus|evm.model.CM009498.1.296 P48644 AL1A1_BOVIN 100.000 0.996016 1.002 ALDH1A1 - Retinal dehydrogenase 1 - Bos taurus (Bovine) - ALDH1A1 gene Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal. May have a broader specificity and oxidize other aldehydes in vivo. Indicus|evm.model.CM009498.1.298 P46193 ANXA1_BOVIN 99.422 0.994236 1.00289 ANXA1 - Annexin A1 - Bos taurus (Bovine) - ANXA1 gene Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). Indicus|evm.model.CM009498.1.299 Q13309 SKP2_HUMAN 90.698 0.971591 0.415094 SKP2 - S-phase kinase-associated protein 2 - Homo sapiens (Human) - SKP2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Indicus|evm.model.CM009498.1.300 Q3SZ63 NOP56_BOVIN 88.235 0.704225 0.119128 NOP56 - Nucleolar protein 56 - Bos taurus (Bovine) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Indicus|evm.model.CM009498.1.302 Q92753 RORB_HUMAN 98.723 0.995754 1.00213 RORB - Nuclear receptor ROR-beta - Homo sapiens (Human) - RORB gene Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity). Indicus|evm.model.CM009498.1.304 Q9BX84 TRPM6_HUMAN 83.760 0.997537 1.00396 TRPM6 - Transient receptor potential cation channel subfamily M member 6 - Homo sapiens (Human) - TRPM6 gene Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. Indicus|evm.model.CM009498.1.305 Q8IXQ3 CI040_HUMAN 72.308 0.989796 1.01031 C9orf40 - Uncharacterized protein C9orf40 - Homo sapiens (Human) - C9orf40 gene Indicus|evm.model.CM009498.1.306 Q8N4J0 CARME_HUMAN 96.154 0.85567 1.18582 CARNMT1 - Carnosine N-methyltransferase - Homo sapiens (Human) - CARNMT1 gene N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). Indicus|evm.model.CM009498.1.307 Q9NWW6 NRK1_HUMAN 85.427 0.99 1.00503 NMRK1 - Nicotinamide riboside kinase 1 - Homo sapiens (Human) - NMRK1 gene Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine. Indicus|evm.model.CM009498.1.308 Q8MJ50 OSTF1_BOVIN 100.000 0.990698 1.00467 OSTF1 - Osteoclast-stimulating factor 1 - Bos taurus (Bovine) - OSTF1 gene Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity. Indicus|evm.model.CM009498.1.309 P63159 HMGB1_RAT 65.772 0.983471 0.562791 Hmgb1 - High mobility group protein B1 - Rattus norvegicus (Rat) - Hmgb1 gene Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide (PubMed:11154118). Bound to RAGE mediates signaling for neuronal outgrowth (PubMed:1885601, PubMed:2461949, PubMed:7592757, PubMed:12183440). May play a role in accumulation of expanded polyglutamine (polyQ) proteins. Indicus|evm.model.CM009498.1.310 Q92824 PCSK5_HUMAN 96.923 0.213333 0.16129 PCSK5 - Proprotein convertase subtilisin/kexin type 5 precursor - Homo sapiens (Human) - PCSK5 gene Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Indicus|evm.model.CM009498.1.311 P41413 PCSK5_RAT 79.435 0.995244 0.464898 Pcsk5 - Proprotein convertase subtilisin/kexin type 5 precursor - Rattus norvegicus (Rat) - Pcsk5 gene Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors. Indicus|evm.model.CM009498.1.312 Q92824 PCSK5_HUMAN 78.475 0.986555 0.319892 PCSK5 - Proprotein convertase subtilisin/kexin type 5 precursor - Homo sapiens (Human) - PCSK5 gene Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Indicus|evm.model.CM009498.1.313 Q969G6 RIFK_HUMAN 94.839 0.987179 1.00645 RFK - Riboflavin kinase - Homo sapiens (Human) - RFK gene Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. Indicus|evm.model.CM009498.1.316 Q92180 GCNT1_BOVIN 99.299 0.995338 1.00468 GCNT1 - Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase - Bos taurus (Bovine) - GCNT1 gene Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. Indicus|evm.model.CM009498.1.317 Q5R4Q8 PRUN2_PONAB 91.045 0.108795 9.50464 PRUNE2 - Protein prune homolog 2 - Pongo abelii (Sumatran orangutan) - PRUNE2 gene May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. Indicus|evm.model.CM009498.1.318 Q64733 FOXB2_MOUSE 100.000 0.238307 1.04907 Foxb2 - Forkhead box protein B2 - Mus musculus (Mouse) - Foxb2 gene Transcription factor. Indicus|evm.model.CM009498.1.319 Q96RL7 VP13A_HUMAN 84.692 0.469756 0.401071 VPS13A - Vacuolar protein sorting-associated protein 13A - Homo sapiens (Human) - VPS13A gene Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (PubMed:30741634). Negatively regulates lipid droplet size and motility (PubMed:30741634). Required for efficient lysosomal protein degradation (PubMed:30709847). Indicus|evm.model.CM009498.1.320 Q5H8C4 VP13A_MOUSE 93.636 0.981982 0.03506 Vps13a - Vacuolar protein sorting-associated protein 13A - Mus musculus (Mouse) - Vps13a gene Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (By similarity). Negatively regulates lipid droplet size and motility (By similarity). Required for efficient lysosomal protein degradation (By similarity). Indicus|evm.model.CM009498.1.321 P38408 GNA14_BOVIN 100.000 0.994382 1.00282 GNA14 - Guanine nucleotide-binding protein subunit alpha-14 - Bos taurus (Bovine) - GNA14 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Indicus|evm.model.CM009498.1.322 Q2PKF4 GNAQ_PIG 99.502 0.956938 0.582173 GNAQ - Guanine nucleotide-binding protein G(q) subunit alpha - Sus scrofa (Pig) - GNAQ gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Indicus|evm.model.CM009498.1.323 P82471 GNAQ_RAT 100.000 0.411215 0.29805 Gnaq - Guanine nucleotide-binding protein G(q) subunit alpha - Rattus norvegicus (Rat) - Gnaq gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Indicus|evm.model.CM009498.1.324 Q5JTW2 CEP78_HUMAN 83.003 0.873606 1.17126 CEP78 - Centrosomal protein of 78 kDa - Homo sapiens (Human) - CEP78 gene May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). May play a role in cilium biogenesis (PubMed:27588451). Indicus|evm.model.CM009498.1.325 Q9Y617 SERC_HUMAN 92.973 0.85814 1.16216 PSAT1 - Phosphoserine aminotransferase - Homo sapiens (Human) - PSAT1 gene Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Indicus|evm.model.CM009498.1.326 P62828 RAN_RAT 91.667 0.986239 1.00926 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Indicus|evm.model.CM009498.1.327 Q04727 TLE4_HUMAN 99.225 0.997419 1.00259 TLE4 - Transducin-like enhancer protein 4 - Homo sapiens (Human) - TLE4 gene Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Indicus|evm.model.CM009498.1.330 Q6W3F4 AA2BR_CANLF 71.875 0.352273 0.26506 ADORA2B - Adenosine receptor A2b - Canis lupus familiaris (Dog) - ADORA2B gene Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Indicus|evm.model.CM009498.1.331 Q04724 TLE1_HUMAN 77.173 0.997093 0.893506 TLE1 - Transducin-like enhancer protein 1 - Homo sapiens (Human) - TLE1 gene Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. Indicus|evm.model.CM009498.1.332 Q04727 TLE4_HUMAN 98.611 0.71 0.129366 TLE4 - Transducin-like enhancer protein 4 - Homo sapiens (Human) - TLE4 gene Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Indicus|evm.model.CM009498.1.333 Q6ZUB0 S31D4_HUMAN 53.145 0.609622 1.5867 SPATA31D4 - Spermatogenesis-associated protein 31D4 - Homo sapiens (Human) - SPATA31D4 gene May play a role in spermatogenesis. Indicus|evm.model.CM009498.1.336 Q63HN1 F205B_HUMAN 65.832 0.417854 2.39748 FAM205BP - Putative protein FAM205B - Homo sapiens (Human) - FAM205BP gene Indicus|evm.model.CM009498.1.337 Q32LN6 F205C_BOVIN 98.775 0.99511 1.00245 FAM205C - Protein FAM205C - Bos taurus (Bovine) - FAM205C gene Indicus|evm.model.CM009498.1.338 Q9UPV7 PHF24_HUMAN 92.500 0.995012 1.0025 PHF24 - PHD finger protein 24 - Homo sapiens (Human) - PHF24 gene Indicus|evm.model.CM009498.1.339 Q5BIP8 DNJB5_BOVIN 100.000 0.824228 1.20977 DNAJB5 - DnaJ homolog subfamily B member 5 - Bos taurus (Bovine) - DNAJB5 gene cytosol, chaperone binding, unfolded protein binding, chaperone cofactor-dependent protein refolding Indicus|evm.model.CM009498.1.340 Q5VYM1 CI131_HUMAN 52.789 0.618197 1.14087 C9orf131 - Uncharacterized protein C9orf131 - Homo sapiens (Human) - C9orf131 gene Indicus|evm.model.CM009498.1.341 Q3ZBT1 TERA_BOVIN 99.876 0.997522 1.00124 VCP - Transitional endoplasmic reticulum ATPase - Bos taurus (Bovine) - VCP gene Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Plays a role in the regulation of stress granules (SGs) clearance process upon arsenite-induced response (By similarity). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis. Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy. Acts as a negative regulator of type I interferon production by interacting with DDX58/RIG-I: interaction takes place when DDX58/RIG-I is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I. May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation. May more particularly play a role in caveolins sorting in cells. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Indicus|evm.model.CM009498.1.342 O15287 FANCG_HUMAN 80.165 0.969502 1.00161 FANCG - Fanconi anemia group G protein - Homo sapiens (Human) - FANCG gene DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. Indicus|evm.model.CM009498.1.343 Q32LL2 STML2_BOVIN 99.716 0.229112 4.30337 STOML2 - Stomatin-like protein 2, mitochondrial precursor - Bos taurus (Bovine) - STOML2 gene Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation (By similarity). Indicus|evm.model.CM009498.1.344 Q5BIM2 F214B_BOVIN 99.442 0.85103 1.17286 FAM214B - Protein FAM214B - Bos taurus (Bovine) - FAM214B gene Indicus|evm.model.CM009498.1.345 O14795 UN13B_HUMAN 95.663 0.998744 1.00063 UNC13B - Protein unc-13 homolog B - Homo sapiens (Human) - UNC13B gene Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Indicus|evm.model.CM009498.1.346 A3FIN4 AT8B5_MOUSE 77.386 0.994007 0.98732 Atp8b5 - Phospholipid-transporting ATPase FetA - Mus musculus (Mouse) - Atp8b5 gene P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in phospholid transport across membranes and in acrosome formation. Indicus|evm.model.CM009498.1.347 Q8N2Y8 RUSC2_HUMAN 89.141 0.983455 0.996702 RUSC2 - Iporin - Homo sapiens (Human) - RUSC2 gene cytoplasmic vesicle, extracellular exosome, small GTPase binding Indicus|evm.model.CM009498.1.348 Q2TBR5 F166B_BOVIN 100.000 0.992727 1.00365 FAM166B - Protein FAM166B - Bos taurus (Bovine) - FAM166B gene Indicus|evm.model.CM009498.1.349 Q15569 TESK1_HUMAN 94.426 0.936609 1.00799 TESK1 - Dual specificity testis-specific protein kinase 1 - Homo sapiens (Human) - TESK1 gene Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). Indicus|evm.model.CM009498.1.350 P21854 CD72_HUMAN 60.109 0.977839 1.00557 CD72 - B-cell differentiation antigen CD72 - Homo sapiens (Human) - CD72 gene Plays a role in B-cell proliferation and differentiation. Indicus|evm.model.CM009498.1.351 Q9Y3P8 SIT1_HUMAN 78.378 0.989247 0.94898 SIT1 - Signaling threshold-regulating transmembrane adapter 1 precursor - Homo sapiens (Human) - SIT1 gene Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. Indicus|evm.model.CM009498.1.352 Q2NL23 CC107_BOVIN 100.000 0.992278 1.00388 CCDC107 - Coiled-coil domain-containing protein 107 precursor - Bos taurus (Bovine) - CCDC107 gene Indicus|evm.model.CM009498.1.353 Q0P5E3 ARG39_BOVIN 100.000 0.994048 1.00299 ARHGEF39 - Rho guanine nucleotide exchange factor 39 - Bos taurus (Bovine) - ARHGEF39 gene Promotes cell proliferation. Indicus|evm.model.CM009498.1.354 Q16790 CAH9_HUMAN 80.694 0.843691 1.15686 CA9 - Carbonic anhydrase 9 precursor - Homo sapiens (Human) - CA9 gene Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Indicus|evm.model.CM009498.1.355 P58775 TPM2_RAT 92.606 0.992982 1.00352 Tpm2 - Tropomyosin beta chain - Rattus norvegicus (Rat) - Tpm2 gene Binds to actin filaments in muscle and non-muscle cells (PubMed:7568216, PubMed:22812662). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:22812662). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity). Indicus|evm.model.CM009498.1.356 Q9Y490 TLN1_HUMAN 98.977 0.999213 1.00039 TLN1 - Talin-1 - Homo sapiens (Human) - TLN1 gene Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). Indicus|evm.model.CM009498.1.357 Q8SQ19 CREB3_BOVIN 100.000 0.99458 1.00272 CREB3 - Cyclic AMP-responsive element-binding protein 3 - Bos taurus (Bovine) - CREB3 gene Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription. Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death. Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Associates with chromatin to the HERPUD1 promoter. Also induces transcriptional activation of chemokine receptors. Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells. Indicus|evm.model.CM009498.1.358 Q9HCG7 GBA2_HUMAN 87.826 0.997824 0.99137 GBA2 - Non-lysosomal glucosylceramidase - Homo sapiens (Human) - GBA2 gene Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide (PubMed:17105727, PubMed:30308956). Glucosylceramides are membrane glycosphingolipids that have a wide intracellular distribution (By similarity). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (By similarity). Also involved in the transglucosylation of cholesterol, transferring glucose from glucosylceramides, thereby modifying its water solubility and biological properties (By similarity). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (By similarity). Finally, may also play a role in the metabolism of bile acids (PubMed:11489889, PubMed:9111029, PubMed:17080196). It is able to hydrolyze bile acid 3-O-glucosides but also to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PubMed:11489889, PubMed:9111029, PubMed:17080196). However, the relevance of both activities is unclear in vivo (By similarity). Indicus|evm.model.CM009498.1.359 Q2T9P3 RGP1_BOVIN 99.728 0.936224 0.994924 RGP1 - RAB6A-GEF complex partner protein 2 - Bos taurus (Bovine) - RGP1 gene The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Indicus|evm.model.CM009498.1.360 Q1L6U9 MSMP_HUMAN 91.367 0.985714 1.00719 MSMP - Prostate-associated microseminoprotein precursor - Homo sapiens (Human) - MSMP gene Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:24442440). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:24442440). Exhibits a chemotactic activity for monocytes and lymphocytes but not neutrophils (PubMed:24442440). Indicus|evm.model.CM009498.1.361 P46197 ANPRB_BOVIN 100.000 0.941529 0.637058 NPR2 - Atrial natriuretic peptide receptor 2 precursor - Bos taurus (Bovine) - NPR2 gene Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. Indicus|evm.model.CM009498.1.362 P46197 ANPRB_BOVIN 98.595 0.986079 0.411652 NPR2 - Atrial natriuretic peptide receptor 2 precursor - Bos taurus (Bovine) - NPR2 gene Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. Indicus|evm.model.CM009498.1.363 Q99932 SPAG8_HUMAN 62.069 0.975258 1 SPAG8 - Sperm-associated antigen 8 - Homo sapiens (Human) - SPAG8 gene Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252). Indicus|evm.model.CM009498.1.364 Q8SQ21 HINT2_BOVIN 98.788 0.987952 1.0184 HINT2 - Histidine triad nucleotide-binding protein 2, mitochondrial precursor - Bos taurus (Bovine) - HINT2 gene Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity (By similarity). Indicus|evm.model.CM009498.1.365 A6H8Z2 F221B_HUMAN 63.196 0.877419 1.15672 FAM221B - Protein FAM221B - Homo sapiens (Human) - FAM221B gene Indicus|evm.model.CM009498.1.366 A6QLK4 TMM8B_BOVIN 100.000 0.505908 1.97246 TMEM8B - Transmembrane protein 8B - Bos taurus (Bovine) - TMEM8B gene May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity). Indicus|evm.model.CM009498.1.367 Q6UXD1 HRCT1_HUMAN 62.069 0.747826 1 HRCT1 - Histidine-rich carboxyl terminus protein 1 - Homo sapiens (Human) - HRCT1 gene Indicus|evm.model.CM009498.1.368 A0A1B0GVQ0 SPAR_HUMAN 86.154 0.463768 1.53333 SPAAR - Small regulatory polypeptide of amino acid response - Homo sapiens (Human) - SPAAR gene Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity). Indicus|evm.model.CM009498.1.369 O95980 RECK_HUMAN 93.210 0.997945 1.00206 RECK - Reversion-inducing cysteine-rich protein with Kazal motifs precursor - Homo sapiens (Human) - RECK gene Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069). Indicus|evm.model.CM009498.1.370 Q9H4G4 GAPR1_HUMAN 96.104 0.987097 1.00649 GLIPR2 - Golgi-associated plant pathogenesis-related protein 1 - Homo sapiens (Human) - GLIPR2 gene extracellular exosome, extracellular space, Golgi membrane, protein homodimerization activity, positive regulation of epithelial cell migration, positive regulation of epithelial to mesenchymal transition, positive regulation of ERK1 and ERK2 cascade Indicus|evm.model.CM009498.1.371 Q28068 CALI_BOVIN 100.000 0.996604 1.0017 CCIN - Calicin - Bos taurus (Bovine) - CCIN gene Possible morphogenic cytoskeletal element in spermiogenic differentiation. Indicus|evm.model.CM009498.1.372 P04973 CLCA_BOVIN 100.000 0.991803 1.00412 CLTA - Clathrin light chain A - Bos taurus (Bovine) - CLTA gene Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (By similarity). Indicus|evm.model.CM009498.1.373 Q9Y223 GLCNE_HUMAN 98.338 0.997234 1.00139 GNE - Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase - Homo sapiens (Human) - GNE gene Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Indicus|evm.model.CM009498.1.374 Q9H0F5 RNF38_HUMAN 98.633 0.907638 1.0932 RNF38 - E3 ubiquitin-protein ligase RNF38 - Homo sapiens (Human) - RNF38 gene Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme. Indicus|evm.model.CM009498.1.375 Q14680 MELK_HUMAN 89.555 0.996928 1 MELK - Maternal embryonic leucine zipper kinase - Homo sapiens (Human) - MELK gene Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. Indicus|evm.model.CM009498.1.376 Q02650 PAX5_MOUSE 98.611 0.859281 0.85422 Pax5 - Paired box protein Pax-5 - Mus musculus (Mouse) - Pax5 gene Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:9042861). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:16546096). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:9042861, PubMed:16546096). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (By similarity). Indicus|evm.model.CM009498.1.377 Q2KIN0 ZCHC7_BOVIN 99.634 0.996344 1.00183 ZCCHC7 - Zinc finger CCHC domain-containing protein 7 - Bos taurus (Bovine) - ZCCHC7 gene Indicus|evm.model.CM009498.1.378 P62752 RL23A_RAT 49.558 0.655462 0.762821 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009498.1.379 Q9UBQ7 GRHPR_HUMAN 88.720 0.993921 1.00305 GRHPR - Glyoxylate reductase/hydroxypyruvate reductase - Homo sapiens (Human) - GRHPR gene Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. Indicus|evm.model.CM009498.1.380 O15062 ZBTB5_HUMAN 95.273 0.946704 1.05318 ZBTB5 - Zinc finger and BTB domain-containing protein 5 - Homo sapiens (Human) - ZBTB5 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009498.1.381 Q9GZS1 RPA49_HUMAN 87.112 0.995238 1.00239 POLR1E - DNA-directed RNA polymerase I subunit RPA49 - Homo sapiens (Human) - POLR1E gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors (PubMed:24207024). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:24207024). Indicus|evm.model.CM009498.1.382 Q5R676 TOM5_PONAB 90.909 0.0414658 20.3333 TOMM5 - Mitochondrial import receptor subunit TOM5 homolog - Pongo abelii (Sumatran orangutan) - TOMM5 gene mitochondrial outer membrane translocase complex, protein targeting to mitochondrion Indicus|evm.model.CM009498.1.385 Q5SYB0 FRPD1_HUMAN 81.195 0.998741 1.00634 FRMPD1 - FERM and PDZ domain-containing protein 1 - Homo sapiens (Human) - FRMPD1 gene Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. Indicus|evm.model.CM009498.1.386 Q08DP1 TM10B_BOVIN 83.544 0.992727 0.870253 TRMT10B - tRNA methyltransferase 10 homolog B - Bos taurus (Bovine) - TRMT10B gene S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs. Indicus|evm.model.CM009498.1.387 Q3T0E1 EXOS3_BOVIN 100.000 0.992754 1.00364 EXOSC3 - Exosome complex component RRP40 - Bos taurus (Bovine) - EXOSC3 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5 (By similarity). Indicus|evm.model.CM009498.1.389 A2AKB9 DCA10_MOUSE 96.087 0.706154 1.14841 Dcaf10 - DDB1- and CUL4-associated factor 10 - Mus musculus (Mouse) - Dcaf10 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Indicus|evm.model.CM009498.1.390 Q9H1U9 S2551_HUMAN 93.603 0.993289 1.00337 SLC25A51 - Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 - Homo sapiens (Human) - SLC25A51 gene Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:32906142). Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration (PubMed:32906142). Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria (PubMed:32906142). Indicus|evm.model.CM009498.1.391 Q15464 SHB_HUMAN 96.857 0.996063 0.998035 SHB - SH2 domain-containing adapter protein B - Homo sapiens (Human) - SHB gene Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. Indicus|evm.model.CM009498.1.392 O15347 HMGB3_HUMAN 77.381 0.7 1 HMGB3 - High mobility group protein B3 - Homo sapiens (Human) - HMGB3 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). Indicus|evm.model.CM009498.1.393 P52476 AL1B1_BOVIN 98.810 0.983568 0.833659 ALDH1B1 - Aldehyde dehydrogenase X, mitochondrial precursor - Bos taurus (Bovine) - ALDH1B1 gene ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. In the cornea, this enzyme may help in the absorption of the damaging UV-B, as well as in the detoxification of the UV-induced peroxidic aldehydes. Indicus|evm.model.CM009498.1.394 A5PKD8 IBPL1_BOVIN 86.131 0.784483 1.27007 IGFBPL1 - Insulin-like growth factor-binding protein-like 1 precursor - Bos taurus (Bovine) - IGFBPL1 gene IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). Indicus|evm.model.CM009498.1.395 Q9DBN1 STR6L_MOUSE 79.194 0.995153 0.996779 Stra6l - Stimulated by retinoic acid gene 6 protein-like - Mus musculus (Mouse) - Stra6l gene Acts as a high-affinity cell-surface receptor for retinol-binding protein RBP4 and mediates RBP4-dependent retinol uptake in the liver. Indicus|evm.model.CM009498.1.396 Q9P1Z9 CC180_HUMAN 69.675 0.998769 0.95532 CCDC180 - Coiled-coil domain-containing protein 180 - Homo sapiens (Human) - CCDC180 gene extracellular exosome Indicus|evm.model.CM009498.1.397 P54252 ATX3_HUMAN 76.976 0.790997 0.861496 ATXN3 - Ataxin-3 - Homo sapiens (Human) - ATXN3 gene Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). Indicus|evm.model.CM009498.1.398 A6QLE1 TDRD7_BOVIN 99.818 0.99818 1.00091 TDRD7 - Tudor domain-containing protein 7 - Bos taurus (Bovine) - TDRD7 gene Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis (By similarity). Indicus|evm.model.CM009498.1.399 A0JNC0 TMOD1_BOVIN 100.000 0.994444 1.00279 TMOD1 - Tropomodulin-1 - Bos taurus (Bovine) - TMOD1 gene Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus (By similarity). Indicus|evm.model.CM009498.1.400 Q5T7W7 TSTD2_HUMAN 84.221 0.978599 0.996124 TSTD2 - Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 - Homo sapiens (Human) - TSTD2 gene Indicus|evm.model.CM009498.1.401 Q09161 NCBP1_HUMAN 99.114 0.997472 1.00127 NCBP1 - Nuclear cap-binding protein subunit 1 - Homo sapiens (Human) - NCBP1 gene Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (PubMed:26382858). Indicus|evm.model.CM009498.1.402 P23025 XPA_HUMAN 91.575 0.992701 1.00366 XPA - DNA repair protein complementing XP-A cells - Homo sapiens (Human) - XPA gene Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Indicus|evm.model.CM009498.1.403 O00358 FOXE1_HUMAN 91.200 0.994652 1.00268 FOXE1 - Forkhead box protein E1 - Homo sapiens (Human) - FOXE1 gene Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. Indicus|evm.model.CM009498.1.404 Q9BU70 TRMO_HUMAN 74.718 0.995423 0.99093 TRMO - tRNA (adenine(37)-N6)-methyltransferase - Homo sapiens (Human) - TRMO gene S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity). Indicus|evm.model.CM009498.1.405 Q32L62 HEMGN_BOVIN 99.105 0.995536 1.00224 HEMGN - Hemogen - Bos taurus (Bovine) - HEMGN gene Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity). Indicus|evm.model.CM009498.1.406 Q3SZC6 AN32B_BOVIN 96.875 0.700441 0.869732 ANP32B - Acidic leucine-rich nuclear phosphoprotein 32 family member B - Bos taurus (Bovine) - ANP32B gene Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription. Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis. Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes. Plays also an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (By similarity). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). Indicus|evm.model.CM009498.1.407 Q9NR45 SIAS_HUMAN 96.657 0.994444 1.00279 NANS - Sialic acid synthase - Homo sapiens (Human) - NANS gene Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Indicus|evm.model.CM009498.1.408 Q14142 TRI14_HUMAN 69.265 0.995227 0.947964 TRIM14 - Tripartite motif-containing protein 14 - Homo sapiens (Human) - TRIM14 gene Plays an essential role in the innate immune defense against viruses and bacteria (PubMed:30150992, PubMed:32404352). Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression (PubMed:32404352). Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity). Indicus|evm.model.CM009498.1.409 Q32LP9 COR2A_BOVIN 99.810 0.996198 1.0019 CORO2A - Coronin-2A - Bos taurus (Bovine) - CORO2A gene actin filament binding Indicus|evm.model.CM009498.1.410 A6QP29 TBD2A_BOVIN 99.459 0.99784 1.00108 TBC1D2 - TBC1 domain family member 2A - Bos taurus (Bovine) - TBC1D2 gene May act as a GTPase-activating protein for Rab family protein(s). Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and further inhibition of cadherin degradation (By similarity). Indicus|evm.model.CM009498.1.411 O75899 GABR2_HUMAN 95.259 0.996918 0.689692 GABBR2 - Gamma-aminobutyric acid type B receptor subunit 2 precursor - Homo sapiens (Human) - GABBR2 gene Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Indicus|evm.model.CM009498.1.414 Q68DC2 ANKS6_HUMAN 93.009 0.793619 1.15155 ANKS6 - Ankyrin repeat and SAM domain-containing protein 6 - Homo sapiens (Human) - ANKS6 gene Required for renal function. Indicus|evm.model.CM009498.1.415 Q8IXK2 GLT12_HUMAN 89.497 0.964059 0.814114 GALNT12 - Polypeptide N-acetylgalactosaminyltransferase 12 - Homo sapiens (Human) - GALNT12 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. Indicus|evm.model.CM009498.1.416 P39059 COFA1_HUMAN 80.546 0.998543 0.989193 COL15A1 - Collagen alpha-1(XV) chain precursor - Homo sapiens (Human) - COL15A1 gene Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. Indicus|evm.model.CM009498.1.417 O46680 TGFR1_BOVIN 100.000 0.996 1.002 TGFBR1 - TGF-beta receptor type-1 precursor - Bos taurus (Bovine) - TGFBR1 gene Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity). Indicus|evm.model.CM009498.1.418 Q9H553 ALG2_HUMAN 89.183 0.995204 1.0024 ALG2 - Alpha-1,3/1,6-mannosyltransferase ALG2 - Homo sapiens (Human) - ALG2 gene Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Indicus|evm.model.CM009498.1.420 Q9GMB0 RPN1_PIG 85.526 0.996716 1.00164 RPN1 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor - Sus scrofa (Pig) - RPN1 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (Probable). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Indicus|evm.model.CM009498.1.421 Q92570 NR4A3_HUMAN 96.649 0.501295 1.23323 NR4A3 - Nuclear receptor subfamily 4 group A member 3 - Homo sapiens (Human) - NR4A3 gene Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Plays also a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). Indicus|evm.model.CM009498.1.422 Q5E9Y2 STX17_BOVIN 99.669 0.993399 1.00331 STX17 - Syntaxin-17 - Bos taurus (Bovine) - STX17 gene SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity). Indicus|evm.model.CM009498.1.423 Q3T0L2 ERP44_BOVIN 100.000 0.995086 1.00246 ERP44 - Endoplasmic reticulum resident protein 44 precursor - Bos taurus (Bovine) - ERP44 gene Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum (By similarity). Indicus|evm.model.CM009498.1.424 Q6JAN1 INVS_CANLF 89.147 0.988062 1.0074 INVS - Inversin - Canis lupus familiaris (Dog) - INVS gene Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Indicus|evm.model.CM009498.1.425 Q9NXF1 TEX10_HUMAN 92.513 0.997863 1.00753 TEX10 - Testis-expressed protein 10 - Homo sapiens (Human) - TEX10 gene Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). Indicus|evm.model.CM009498.1.426 A8MTI9 PRS47_HUMAN 55.786 0.828205 1.04 PRSS47 - Putative serine protease 47 precursor - Homo sapiens (Human) - PRSS47 gene extracellular space, serine-type endopeptidase activity, proteolysis Indicus|evm.model.CM009498.1.429 A8MTI9 PRS47_HUMAN 53.177 0.630485 1.15467 PRSS47 - Putative serine protease 47 precursor - Homo sapiens (Human) - PRSS47 gene extracellular space, serine-type endopeptidase activity, proteolysis Indicus|evm.model.CM009498.1.430 A8MTI9 PRS47_HUMAN 47.234 0.836502 0.701333 PRSS47 - Putative serine protease 47 precursor - Homo sapiens (Human) - PRSS47 gene extracellular space, serine-type endopeptidase activity, proteolysis Indicus|evm.model.CM009498.1.431 P79103 RS4_BOVIN 93.916 0.992424 1.0038 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009498.1.433 Q9BZ76 CNTP3_HUMAN 68.465 0.974205 0.90295 CNTNAP3 - Contactin-associated protein-like 3 precursor - Homo sapiens (Human) - CNTNAP3 gene integral component of membrane, cell recognition Indicus|evm.model.CM009498.1.435 P17032 ZN37A_HUMAN 79.412 0.634615 0.0926916 ZNF37A - Zinc finger protein 37A - Homo sapiens (Human) - ZNF37A gene May be involved in transcriptional regulation. Indicus|evm.model.CM009498.1.437 Q58DT1 RL7_BOVIN 88.636 0.988095 0.677419 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Indicus|evm.model.CM009498.1.438 P54219 VMAT1_HUMAN 80.000 0.996 0.952381 SLC18A1 - Chromaffin granule amine transporter - Homo sapiens (Human) - SLC18A1 gene Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. Indicus|evm.model.CM009498.1.439 P31408 VATB2_BOVIN 100.000 0.996094 1.00196 ATP6V1B2 - V-type proton ATPase subunit B, brain isoform - Bos taurus (Bovine) - ATP6V1B2 gene Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity). Indicus|evm.model.CM009498.1.440 Q9Y250 LZTS1_HUMAN 90.349 0.996644 1 LZTS1 - Leucine zipper putative tumor suppressor 1 - Homo sapiens (Human) - LZTS1 gene Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. Indicus|evm.model.CM009498.1.441 P15880 RS2_HUMAN 71.739 0.986842 0.518771 RPS2 - 40S ribosomal protein S2 - Homo sapiens (Human) - RPS2 gene cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleoplasm, nucleus, cadherin binding, enzyme binding Indicus|evm.model.CM009498.1.442 O18789 RS2_BOVIN 88.372 0.403846 0.354949 RPS2 - 40S ribosomal protein S2 - Bos taurus (Bovine) - RPS2 gene cytosolic small ribosomal subunit, structural constituent of ribosome, translation Indicus|evm.model.CM009498.1.443 Q5E9U0 SP2_BOVIN 98.858 0.996732 0.998369 SP2 - Transcription factor Sp2 - Bos taurus (Bovine) - SP2 gene Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Indicus|evm.model.CM009498.1.444 P84089 ERH_MOUSE 60.870 0.912281 0.548077 Erh - Enhancer of rudimentary homolog - Mus musculus (Mouse) - Erh gene May have a role in the cell cycle. Indicus|evm.model.CM009498.1.447 Q5E9X0 GFRA2_BOVIN 99.784 0.995699 1.00216 GFRA2 - GDNF family receptor alpha-2 precursor - Bos taurus (Bovine) - GFRA2 gene Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (By similarity). Indicus|evm.model.CM009498.1.449 A7MBB8 DOK2_BOVIN 100.000 0.995169 1.00242 DOK2 - Docking protein 2 - Bos taurus (Bovine) - DOK2 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). Indicus|evm.model.CM009498.1.450 Q9UIA9 XPO7_HUMAN 97.913 0.983036 1.03036 XPO7 - Exportin-7 - Homo sapiens (Human) - XPO7 gene Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Indicus|evm.model.CM009498.1.451 O60258 FGF17_HUMAN 89.404 0.471698 1.47222 FGF17 - Fibroblast growth factor 17 precursor - Homo sapiens (Human) - FGF17 gene Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Indicus|evm.model.CM009498.1.452 Q08DM1 DEMA_BOVIN 99.754 0.995074 1 DMTN - Dematin - Bos taurus (Bovine) - DMTN gene Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation (By similarity). Indicus|evm.model.CM009498.1.453 Q80YR2 F16B2_MOUSE 83.288 0.987838 0.994624 Fhip2b - FHF complex subunit HOOK interacting protein 2B - Mus musculus (Mouse) - Fhip2b gene Able to activate MAPK/ERK and TGFB signaling pathways (By similarity). May regulate the activity of genes involved in intestinal barrier function and immunoprotective inflammation (PubMed:31862898). May play a role in cell proliferation (By similarity). Indicus|evm.model.CM009498.1.454 Q6ZVK8 NUD18_HUMAN 84.830 0.993827 1.0031 NUDT18 - 8-oxo-dGDP phosphatase NUDT18 - Homo sapiens (Human) - NUDT18 gene Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. Indicus|evm.model.CM009498.1.455 O43593 HAIR_HUMAN 80.184 0.998318 1 HR - Lysine-specific demethylase hairless - Homo sapiens (Human) - HR gene Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. Indicus|evm.model.CM009498.1.456 Q3ZCI8 REEP4_BOVIN 100.000 0.992248 1.00389 REEP4 - Receptor expression-enhancing protein 4 - Bos taurus (Bovine) - REEP4 gene Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity). Indicus|evm.model.CM009498.1.457 Q1EGL0 LGI3_PANTR 90.876 0.996344 0.998175 LGI3 - Leucine-rich repeat LGI family member 3 precursor - Pan troglodytes (Chimpanzee) - LGI3 gene May participate in the regulation of neuronal exocytosis. Indicus|evm.model.CM009498.1.458 P15783 PSPC_BOVIN 100.000 0.989529 1.00526 SFTPC - Pulmonary surfactant-associated protein C precursor - Bos taurus (Bovine) - SFTPC gene Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. Indicus|evm.model.CM009498.1.459 P98063 BMP1_MOUSE 92.365 0.993464 0.926337 Bmp1 - Bone morphogenetic protein 1 precursor - Mus musculus (Mouse) - Bmp1 gene Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:24419319, PubMed:8951074, PubMed:28068493). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:20181949). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (By similarity). Indicus|evm.model.CM009498.1.460 Q0VD34 PHYIP_BOVIN 100.000 0.993958 1.00303 PHYHIP - Phytanoyl-CoA hydroxylase-interacting protein - Bos taurus (Bovine) - PHYHIP gene Its interaction with PHYH suggests a role in the development of the central system. Indicus|evm.model.CM009498.1.461 Q5E9Z7 RPC4_BOVIN 100.000 0.994987 1.00251 POLR3D - DNA-directed RNA polymerase III subunit RPC4 - Bos taurus (Bovine) - POLR3D gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Indicus|evm.model.CM009498.1.462 Q8TC59 PIWL2_HUMAN 88.489 0.997938 0.996917 PIWIL2 - Piwi-like protein 2 - Homo sapiens (Human) - PIWIL2 gene Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660). Represses circadian rhythms by promoting the stability and activity of core clock components ARNTL/BMAL1 and CLOCK by inhibiting GSK3B-mediated phosphorylation and ubiquitination-dependent degradation of these proteins (PubMed:28903391). Indicus|evm.model.CM009498.1.463 A5D7L5 S39AE_BOVIN 100.000 0.995927 1.00204 SLC39A14 - Metal cation symporter ZIP14 precursor - Bos taurus (Bovine) - SLC39A14 gene Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (By similarity). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions. Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Indicus|evm.model.CM009498.1.464 P48454 PP2BC_HUMAN 93.725 0.967495 1.02148 PPP3CC - Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform - Homo sapiens (Human) - PPP3CC gene Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Indicus|evm.model.CM009498.1.465 O60504 VINEX_HUMAN 83.235 0.931129 1.08197 SORBS3 - Vinexin - Homo sapiens (Human) - SORBS3 gene Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Indicus|evm.model.CM009498.1.467 Q3T0C8 PDLI2_BOVIN 99.138 0.994269 1.00287 PDLIM2 - PDZ and LIM domain protein 2 - Bos taurus (Bovine) - PDLIM2 gene Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity). Indicus|evm.model.CM009498.1.468 Q8NAV2 CH058_HUMAN 58.005 0.992105 1.0411 C8orf58 - Uncharacterized protein C8orf58 - Homo sapiens (Human) - C8orf58 gene Indicus|evm.model.CM009498.1.470 Q5R8S0 CCAR2_PONAB 90.196 0.997819 0.998911 CCAR2 - Cell cycle and apoptosis regulator protein 2 - Pongo abelii (Sumatran orangutan) - CCAR2 gene Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (By similarity). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (By similarity). Inhibits SUV39H1 methyltransferase activity (By similarity). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (By similarity). Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1 (By similarity). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (By similarity). Represses the ligand-dependent transcriptional activation function of ESR2 (By similarity). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (By similarity). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (By similarity). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (By similarity). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (By similarity). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (By similarity). Represses the transcriptional activator activity of BRCA1 (By similarity). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (By similarity). Indicus|evm.model.CM009498.1.471 Q9NQY0 BIN3_HUMAN 95.652 0.992126 1.00395 BIN3 - Bridging integrator 3 - Homo sapiens (Human) - BIN3 gene Involved in cytokinesis and septation where it has a role in the localization of F-actin. Indicus|evm.model.CM009498.1.472 Q06889 EGR3_HUMAN 97.158 0.994845 1.00258 EGR3 - Early growth response protein 3 - Homo sapiens (Human) - EGR3 gene Probable transcription factor involved in muscle spindle development. Indicus|evm.model.CM009498.1.473 Q96S96 PEBP4_HUMAN 72.146 0.904564 1.06167 PEBP4 - Phosphatidylethanolamine-binding protein 4 precursor - Homo sapiens (Human) - PEBP4 gene Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway. Indicus|evm.model.CM009498.1.474 Q91V93 RHBT2_MOUSE 87.535 0.951989 1.00137 Rhobtb2 - Rho-related BTB domain-containing protein 2 - Mus musculus (Mouse) - Rhobtb2 gene cell cortex, cell projection, cytoplasmic vesicle, cytoskeleton, intracellular membrane-bounded organelle, plasma membrane, GTP binding, GTPase activity, protein kinase binding, actin filament organization Indicus|evm.model.CM009498.1.475 Q9BYZ6 RHBT2_HUMAN 91.111 0.928994 0.464924 RHOBTB2 - Rho-related BTB domain-containing protein 2 - Homo sapiens (Human) - RHOBTB2 gene cell cortex, cell projection, cytoplasmic vesicle, cytoskeleton, endosome membrane, intracellular membrane-bounded organelle, plasma membrane, GTP binding, GTPase activity, protein kinase binding Indicus|evm.model.CM009498.1.476 Q91V93 RHBT2_MOUSE 82.407 0.281431 1.42033 Rhobtb2 - Rho-related BTB domain-containing protein 2 - Mus musculus (Mouse) - Rhobtb2 gene cell cortex, cell projection, cytoplasmic vesicle, cytoskeleton, intracellular membrane-bounded organelle, plasma membrane, GTP binding, GTPase activity, protein kinase binding, actin filament organization Indicus|evm.model.CM009498.1.477 O14798 TR10C_HUMAN 46.575 0.376316 1.46718 TNFRSF10C - Tumor necrosis factor receptor superfamily member 10C precursor - Homo sapiens (Human) - TNFRSF10C gene Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Indicus|evm.model.CM009498.1.478 O75335 LIPA4_HUMAN 60.061 0.575139 0.454852 PPFIA4 - Liprin-alpha-4 - Homo sapiens (Human) - PPFIA4 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity). Indicus|evm.model.CM009498.1.480 A6QQT9 HACL2_BOVIN 94.253 0.452632 0.300633 ILVBL - 2-hydroxyacyl-CoA lyase 2 - Bos taurus (Bovine) - ILVBL gene Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. Indicus|evm.model.CM009498.1.481 A6QQT9 HACL2_BOVIN 81.329 0.991319 0.911392 ILVBL - 2-hydroxyacyl-CoA lyase 2 - Bos taurus (Bovine) - ILVBL gene Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. Indicus|evm.model.CM009498.1.482 O14763 TR10B_HUMAN 49.231 0.12549 1.15909 TNFRSF10B - Tumor necrosis factor receptor superfamily member 10B precursor - Homo sapiens (Human) - TNFRSF10B gene Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. Indicus|evm.model.CM009498.1.484 Q8WUX9 CHMP7_HUMAN 96.889 0.995565 0.995585 CHMP7 - Charged multivesicular body protein 7 - Homo sapiens (Human) - CHMP7 gene ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878). Indicus|evm.model.CM009498.1.485 Q9Y3T6 R3HC1_HUMAN 76.712 0.89002 1.11591 R3HCC1 - R3H and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - R3HCC1 gene Indicus|evm.model.CM009498.1.486 A6H737 LOXL2_BOVIN 93.734 0.997403 0.994832 LOXL2 - Lysyl oxidase homolog 2 precursor - Bos taurus (Bovine) - LOXL2 gene Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3. During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription. SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits. Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction. When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. Indicus|evm.model.CM009498.1.487 A6H737 LOXL2_BOVIN 98.077 0.607143 0.108527 LOXL2 - Lysyl oxidase homolog 2 precursor - Bos taurus (Bovine) - LOXL2 gene Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3. During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription. SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits. Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction. When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. Indicus|evm.model.CM009498.1.488 Q9Y227 ENTP4_HUMAN 95.455 0.996759 1.00162 ENTPD4 - Ectonucleoside triphosphate diphosphohydrolase 4 - Homo sapiens (Human) - ENTPD4 gene Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates (PubMed:10858452, PubMed:9556635). Preferentially activated by Ca(2+) over Mg(2+) (PubMed:10858452). Indicus|evm.model.CM009498.1.489 Q3ZBJ8 MFRN1_BOVIN 99.329 0.436578 1.98246 SLC25A37 - Mitoferrin-1 - Bos taurus (Bovine) - SLC25A37 gene Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). Indicus|evm.model.CM009498.1.490 P70061 NKX32_XENLA 77.612 0.275 0.729483 nkx3-2 - Homeobox protein Nkx-3.2 - Xenopus laevis (African clawed frog) - nkx3-2 gene nucleus, DNA binding, positive regulation of transcription by RNA polymerase II Indicus|evm.model.CM009498.1.491 A6NCS4 NKX26_HUMAN 72.848 0.993355 1 NKX2-6 - Homeobox protein Nkx-2.6 - Homo sapiens (Human) - NKX2-6 gene Acts as a transcriptional activator (PubMed:15649947). In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. Indicus|evm.model.CM009498.1.493 Q9N0T1 STC1_BOVIN 100.000 0.991935 1.00405 STC1 - Stanniocalcin-1 precursor - Bos taurus (Bovine) - STC1 gene Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia. Indicus|evm.model.CM009498.1.494 P31950 S10AB_PIG 84.375 0.984375 0.646465 S100A11 - Protein S100-A11 - Sus scrofa (Pig) - S100A11 gene Facilitates the differentiation and the cornification of keratinocytes. Indicus|evm.model.CM009498.1.495 Q63486 RRAGA_RAT 99.099 0.940171 0.373802 Rraga - Ras-related GTP-binding protein A - Rattus norvegicus (Rat) - Rraga gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Indicus|evm.model.CM009498.1.496 O15204 ADEC1_HUMAN 77.056 0.377049 2.59574 ADAMDEC1 - ADAM DEC1 precursor - Homo sapiens (Human) - ADAMDEC1 gene May play an important role in the control of the immune response and during pregnancy. Indicus|evm.model.CM009498.1.497 Q28475 ADAM7_MACFA 68.892 0.997484 1.02448 ADAM7 - Disintegrin and metalloproteinase domain-containing protein 7 precursor - Macaca fascicularis (Crab-eating macaque) - ADAM7 gene May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity). Indicus|evm.model.CM009498.1.499 P04221 MUCM_RABIT 63.466 0.429481 2.29436 Ig mu chain C region membrane-bound form - Oryctolagus cuniculus (Rabbit) Indicus|evm.model.CM009498.1.500 O77788 NFM_BOVIN 98.926 0.861909 1.16523 NEFM - Neurofilament medium polypeptide - Bos taurus (Bovine) - NEFM gene Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). Indicus|evm.model.CM009498.1.502 P02548 NFL_BOVIN 100.000 0.996403 1.0018 NEFL - Neurofilament light polypeptide - Bos taurus (Bovine) - NEFL gene Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). Indicus|evm.model.CM009498.1.503 Q9H7D0 DOCK5_HUMAN 94.706 0.99893 1 DOCK5 - Dedicator of cytokinesis protein 5 - Homo sapiens (Human) - DOCK5 gene Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Indicus|evm.model.CM009498.1.504 Q28588 GON1_SHEEP 96.552 0.633333 1.47541 GNRH1 - Progonadoliberin-1 precursor - Ovis aries (Sheep) - GNRH1 gene Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Indicus|evm.model.CM009498.1.505 Q7L273 KCTD9_HUMAN 98.972 0.994872 1.00257 KCTD9 - BTB/POZ domain-containing protein KCTD9 - Homo sapiens (Human) - KCTD9 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. Indicus|evm.model.CM009498.1.506 Q29RT4 CDCA2_BOVIN 92.098 0.766595 0.461919 CDCA2 - Cell division cycle-associated protein 2 - Bos taurus (Bovine) - CDCA2 gene Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity). Indicus|evm.model.CM009498.1.507 Q29RT4 CDCA2_BOVIN 99.076 0.987203 0.541048 CDCA2 - Cell division cycle-associated protein 2 - Bos taurus (Bovine) - CDCA2 gene Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity). Indicus|evm.model.CM009498.1.508 O08792 COE2_MOUSE 100.000 0.471233 0.634783 Ebf2 - Transcription factor COE2 - Mus musculus (Mouse) - Ebf2 gene Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Indicus|evm.model.CM009498.1.509 Q08DL5 COE2_BOVIN 85.294 0.0884718 0.648696 EBF2 - Transcription factor COE2 - Bos taurus (Bovine) - EBF2 gene Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). Indicus|evm.model.CM009498.1.510 Q08DL5 COE2_BOVIN 100.000 0.84127 0.328696 EBF2 - Transcription factor COE2 - Bos taurus (Bovine) - EBF2 gene Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). Indicus|evm.model.CM009498.1.511 P63150 2ABA_RABIT 100.000 0.995506 0.995526 PPP2R2A - Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform - Oryctolagus cuniculus (Rabbit) - PPP2R2A gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Indicus|evm.model.CM009498.1.512 Q3T013 BNI3L_BOVIN 100.000 0.990909 1.00457 BNIP3L - BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like - Bos taurus (Bovine) - BNIP3L gene Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity). Indicus|evm.model.CM009498.1.513 Q2KIT6 PNMA2_BOVIN 99.725 0.994521 1.00275 PNMA2 - Paraneoplastic antigen Ma2 homolog - Bos taurus (Bovine) - PNMA2 gene Indicus|evm.model.CM009498.1.515 O02675 DPYL2_BOVIN 100.000 0.99651 1.00175 DPYSL2 - Dihydropyrimidinase-related protein 2 - Bos taurus (Bovine) - DPYSL2 gene Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity). Indicus|evm.model.CM009498.1.516 P18130 ADA1A_BOVIN 100.000 0.99061 0.914163 ADRA1A - Alpha-1A adrenergic receptor - Bos taurus (Bovine) - ADRA1A gene This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). Indicus|evm.model.CM009498.1.517 Q5R4C5 STMN4_PONAB 87.500 0.990783 1.14815 STMN4 - Stathmin-4 - Pongo abelii (Sumatran orangutan) - STMN4 gene Exhibits microtubule-destabilizing activity. Indicus|evm.model.CM009498.1.518 Q9UPQ4 TRI35_HUMAN 88.415 0.993927 1.00203 TRIM35 - E3 ubiquitin-protein ligase TRIM35 - Homo sapiens (Human) - TRIM35 gene E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via DDX58/RIG-I signaling pathway (PubMed:32562145). Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145). Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537). Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Indicus|evm.model.CM009498.1.519 Q14289 FAK2_HUMAN 95.762 0.936613 1.04757 PTK2B - Protein-tyrosine kinase 2-beta - Homo sapiens (Human) - PTK2B gene Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. Indicus|evm.model.CM009498.1.520 Q15822 ACHA2_HUMAN 81.509 0.996055 0.958412 CHRNA2 - Neuronal acetylcholine receptor subunit alpha-2 precursor - Homo sapiens (Human) - CHRNA2 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Indicus|evm.model.CM009498.1.521 Q6Q2C2 HYES_PIG 79.459 0.996403 1.0018 EPHX2 - Bifunctional epoxide hydrolase 2 - Sus scrofa (Pig) - EPHX2 gene Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:15308618). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (By similarity). Indicus|evm.model.CM009498.1.522 Q3ZC33 GGLO_BOVIN 100.000 0.995227 0.952273 GULO - L-gulonolactone oxidase - Bos taurus (Bovine) - GULO gene Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate. Indicus|evm.model.CM009498.1.523 Q7YRZ2 APTX_BOVIN 99.433 0.432432 2.28652 APTX - Aprataxin - Bos taurus (Bovine) - APTX gene DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). Indicus|evm.model.CM009498.1.524 Q5E954 DNJA1_BOVIN 100.000 0.994975 1.00252 DNAJA1 - DnaJ homolog subfamily A member 1 precursor - Bos taurus (Bovine) - DNAJA1 gene Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Indicus|evm.model.CM009498.1.525 Q3UKJ7 SMU1_MOUSE 100.000 0.996109 1.00195 Smu1 - WD40 repeat-containing protein SMU1 - Mus musculus (Mouse) - Smu1 gene Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). Indicus|evm.model.CM009498.1.526 P02301 H3C_MOUSE 52.800 0.970874 0.757353 H3-5 - Histone H3.3C - Mus musculus (Mouse) - H3-5 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009498.1.527 P08037 B4GT1_BOVIN 100.000 0.995037 1.00249 B4GALT1 - Beta-1,4-galactosyltransferase 1 - Bos taurus (Bovine) - B4GALT1 gene The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Indicus|evm.model.CM009498.1.528 P37109 ISK4_PIG 81.944 0.972603 0.848837 SPINK4 - Serine protease inhibitor Kazal-type 4 precursor - Sus scrofa (Pig) - SPINK4 gene Inhibits the glucose-induced insulin secretion from perfused pancreas; also plays a role in the immune system. Does not inhibit trypsin. Indicus|evm.model.CM009498.1.529 Q99933 BAG1_HUMAN 83.475 0.987395 0.689855 BAG1 - BAG family molecular chaperone regulator 1 - Homo sapiens (Human) - BAG1 gene Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). Indicus|evm.model.CM009498.1.530 Q5RBR3 CHMP5_PONAB 99.087 0.990909 1.00457 CHMP5 - Charged multivesicular body protein 5 - Pongo abelii (Sumatran orangutan) - CHMP5 gene Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). Indicus|evm.model.CM009498.1.531 A6QLA0 NFX1_BOVIN 100.000 0.998209 1.0009 NFX1 - Transcriptional repressor NF-X1 - Bos taurus (Bovine) - NFX1 gene Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination (By similarity). Indicus|evm.model.CM009498.1.532 P56403 AQP7_RAT 71.937 0.758308 1.23048 Aqp7 - Aquaporin-7 - Rattus norvegicus (Rat) - Aqp7 gene Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9252401). The channel is also permeable to urea (PubMed:9252401). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity). Indicus|evm.model.CM009498.1.533 Q08DE6 AQP3_BOVIN 99.658 0.993174 1.00342 AQP3 - Aquaporin-3 - Bos taurus (Bovine) - AQP3 gene Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Indicus|evm.model.CM009498.1.534 Q9H6R4 NOL6_HUMAN 89.965 0.998256 1.00087 NOL6 - Nucleolar protein 6 - Homo sapiens (Human) - NOL6 gene condensed nuclear chromosome, CURI complex, mitochondrion, nucleolus, nucleoplasm, small-subunit processome, UTP-C complex, RNA binding, rRNA processing, tRNA export from nucleus Indicus|evm.model.CM009498.1.535 Q29503 UB2R2_RABIT 100.000 0.991632 1.0042 UBE2R2 - Ubiquitin-conjugating enzyme E2 R2 - Oryctolagus cuniculus (Rabbit) - UBE2R2 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin. Indicus|evm.model.CM009498.1.536 Q5T6F2 UBAP2_HUMAN 84.081 0.998208 0.997319 UBAP2 - Ubiquitin-associated protein 2 - Homo sapiens (Human) - UBAP2 gene cytoplasm, nucleus, P-body, cadherin binding, RNA binding, regulation of gene expression Indicus|evm.model.CM009498.1.537 Q3MHH0 DCA12_BOVIN 100.000 0.995595 1.00221 DCAF12 - DDB1- and CUL4-associated factor 12 - Bos taurus (Bovine) - DCAF12 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Indicus|evm.model.CM009498.1.538 Q9NZ09 UBAP1_HUMAN 92.231 0.996024 1.00199 UBAP1 - Ubiquitin-associated protein 1 - Homo sapiens (Human) - UBAP1 gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:24284069, PubMed:22405001, PubMed:31203368). Indicus|evm.model.CM009498.1.539 Q5T7B8 KIF24_HUMAN 74.876 0.998577 1.02705 KIF24 - Kinesin-like protein KIF24 - Homo sapiens (Human) - KIF24 gene Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Indicus|evm.model.CM009498.1.540 Q29RJ1 AP4A_BOVIN 98.639 0.986486 1.0068 NUDT2 - Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] - Bos taurus (Bovine) - NUDT2 gene Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. Indicus|evm.model.CM009498.1.541 Q6NSJ0 MYORG_HUMAN 93.846 0.997203 1.0014 MYORG - Myogenesis-regulating glycosidase - Homo sapiens (Human) - MYORG gene Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2. Indicus|evm.model.CM009498.1.542 Q32KP0 SMRP1_BOVIN 100.000 0.993443 1.00329 SMRP1 - Spermatid-specific manchette-related protein 1 - Bos taurus (Bovine) - SMRP1 gene May play a role in spermatogenesis. May be involved in differentiation or function of ciliated cells (By similarity). Indicus|evm.model.CM009498.1.543 Q8IW50 F219A_HUMAN 100.000 0.989247 1.00541 FAM219A - Protein FAM219A - Homo sapiens (Human) - FAM219A gene Indicus|evm.model.CM009498.1.544 Q32KS2 DNAI1_BOVIN 98.433 0.99711 0.985755 DNAI1 - Dynein axonemal intermediate chain 1 - Bos taurus (Bovine) - DNAI1 gene Part of the dynein complex of respiratory cilia. Indicus|evm.model.CM009498.1.545 A2VE22 ENHO_BOVIN 98.611 0.139764 6.68421 ENHO - Adropin precursor - Bos taurus (Bovine) - ENHO gene Involved in the regulation of glucose homeostasis and lipid metabolism. Indicus|evm.model.CM009498.1.547 Q2KIR4 RP25L_BOVIN 100.000 0.987805 1.00613 RPP25L - Ribonuclease P protein subunit p25-like protein - Bos taurus (Bovine) - RPP25L gene May be a component of ribonuclease P or MRP. Indicus|evm.model.CM009498.1.548 Q0P5A1 DCTN3_BOVIN 100.000 0.989305 1.00538 DCTN3 - Dynactin subunit 3 - Bos taurus (Bovine) - DCTN3 gene Together with dynein may be involved in spindle assembly and cytokinesis. Indicus|evm.model.CM009498.1.549 A6NKF2 ARI3C_HUMAN 80.928 0.938424 0.985437 ARID3C - AT-rich interactive domain-containing protein 3C - Homo sapiens (Human) - ARID3C gene membrane raft, nucleus, DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009498.1.550 Q58DH7 SGMR1_BOVIN 100.000 0.991071 1.00448 SIGMAR1 - Sigma non-opioid intracellular receptor 1 - Bos taurus (Bovine) - SIGMAR1 gene Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity). Indicus|evm.model.CM009498.1.551 P07902 GALT_HUMAN 92.997 0.98615 0.952507 GALT - Galactose-1-phosphate uridylyltransferase - Homo sapiens (Human) - GALT gene Plays an important role in galactose metabolism. Indicus|evm.model.CM009498.1.552 Q5RF19 I11RA_PONAB 85.782 0.995272 1.00237 IL11RA - Interleukin-11 receptor subunit alpha precursor - Pongo abelii (Sumatran orangutan) - IL11RA gene Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Indicus|evm.model.CM009498.1.553 Q9Z1X0 CCL27_MOUSE 68.421 0.783333 1 Ccl27 - C-C motif chemokine 27 precursor - Mus musculus (Mouse) - Ccl27 gene Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10. Indicus|evm.model.CM009498.1.555 O70460 CCL19_MOUSE 73.958 0.902913 0.953704 Ccl19 - C-C motif chemokine 19 precursor - Mus musculus (Mouse) - Ccl19 gene Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. Indicus|evm.model.CM009498.1.556 O00585 CCL21_HUMAN 73.282 0.970149 1 CCL21 - C-C motif chemokine 21 precursor - Homo sapiens (Human) - CCL21 gene Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. Indicus|evm.model.CM009498.1.557 Q63HN1 F205B_HUMAN 60.432 0.423529 2.29317 FAM205BP - Putative protein FAM205B - Homo sapiens (Human) - FAM205BP gene Indicus|evm.model.CM009498.1.558 Q8IZ41 RASEF_HUMAN 89.595 0.997301 1.00135 RASEF - Ras and EF-hand domain-containing protein - Homo sapiens (Human) - RASEF gene Binds predominantly GDP, and also GTP (PubMed:17448446). Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules (PubMed:30814157). Indicus|evm.model.CM009498.1.559 A2A2Y4 FRMD3_HUMAN 95.477 0.99665 1 FRMD3 - FERM domain-containing protein 3 - Homo sapiens (Human) - FRMD3 gene Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. Indicus|evm.model.CM009498.1.560 Q5T6J7 GNTK_HUMAN 81.622 0.989247 0.994652 IDNK - Probable gluconokinase - Homo sapiens (Human) - IDNK gene gluconokinase activity, D-gluconate catabolic process Indicus|evm.model.CM009498.1.561 Q9UMX0 UBQL1_HUMAN 94.737 0.99661 1.0017 UBQLN1 - Ubiquilin-1 - Homo sapiens (Human) - UBQLN1 gene Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Isoform 1 and isoform 3 play a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Indicus|evm.model.CM009498.1.562 Q9UL54 TAOK2_HUMAN 88.087 0.975265 0.22915 TAOK2 - Serine/threonine-protein kinase TAO2 - Homo sapiens (Human) - TAOK2 gene Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. Indicus|evm.model.CM009498.1.563 Q32LE2 GKAP1_BOVIN 85.124 0.993651 0.867769 GKAP1 - G kinase-anchoring protein 1 - Bos taurus (Bovine) - GKAP1 gene Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. Indicus|evm.model.CM009498.1.564 Q86VH2 KIF27_HUMAN 87.009 0.998567 0.996431 KIF27 - Kinesin-like protein KIF27 - Homo sapiens (Human) - KIF27 gene Plays an essential role in motile ciliogenesis. Indicus|evm.model.CM009498.1.565 Q1JP73 QSPP_BOVIN 99.413 0.994152 1.00293 Queuosine salvage protein - Bos taurus (Bovine) Indicus|evm.model.CM009498.1.566 Q3T0D0 HNRPK_BOVIN 100.000 0.995699 1.00216 HNRNPK - Heterogeneous nuclear ribonucleoprotein K - Bos taurus (Bovine) - HNRNPK gene One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). Indicus|evm.model.CM009498.1.567 A4IF98 RMI1_BOVIN 99.359 0.9968 1.0016 RMI1 - RecQ-mediated genome instability protein 1 - Bos taurus (Bovine) - RMI1 gene Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity). Indicus|evm.model.CM009498.1.569 Q9HAS3 S28A3_HUMAN 79.769 0.988539 1.01013 SLC28A3 - Solute carrier family 28 member 3 - Homo sapiens (Human) - SLC28A3 gene Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine. Indicus|evm.model.CM009498.1.570 A1XQR9 RUXE_PIG 89.855 0.971429 0.76087 SNRPE - Small nuclear ribonucleoprotein E - Sus scrofa (Pig) - SNRPE gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. Indicus|evm.model.CM009498.1.571 Q16620 NTRK2_HUMAN 92.918 0.972746 0.580292 NTRK2 - BDNF/NT-3 growth factors receptor precursor - Homo sapiens (Human) - NTRK2 gene Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. Indicus|evm.model.CM009498.1.572 Q16620 NTRK2_HUMAN 100.000 0.872549 0.49635 NTRK2 - BDNF/NT-3 growth factors receptor precursor - Homo sapiens (Human) - NTRK2 gene Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. Indicus|evm.model.CM009498.1.574 Q9UPW5 CBPC1_HUMAN 94.943 0.997553 1 AGTPBP1 - Cytosolic carboxypeptidase 1 - Homo sapiens (Human) - AGTPBP1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins (PubMed:30420557). Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Indicus|evm.model.CM009498.1.575 Q8VE70 PDC10_MOUSE 77.885 0.988701 0.834906 Pdcd10 - Programmed cell death protein 10 - Mus musculus (Mouse) - Pdcd10 gene Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Indicus|evm.model.CM009498.1.576 Q5RBT3 NAA35_PONAB 99.172 0.90387 1.10483 NAA35 - N-alpha-acetyltransferase 35, NatC auxiliary subunit - Pongo abelii (Sumatran orangutan) - NAA35 gene Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells (By similarity). Indicus|evm.model.CM009498.1.577 Q8NBJ4 GOLM1_HUMAN 81.013 0.994949 0.987531 GOLM1 - Golgi membrane protein 1 - Homo sapiens (Human) - GOLM1 gene Unknown. Cellular response protein to viral infection. Indicus|evm.model.CM009498.1.579 Q5TBE3 CI153_HUMAN 49.333 0.279693 2.58416 C9orf153 - Uncharacterized protein C9orf153 - Homo sapiens (Human) - C9orf153 gene Indicus|evm.model.CM009498.1.580 Q4R5F0 ISCA1_MACFA 100.000 0.984615 1.00775 ISCA1 - Iron-sulfur cluster assembly 1 homolog, mitochondrial precursor - Macaca fascicularis (Crab-eating macaque) - ISCA1 gene Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. Indicus|evm.model.CM009498.1.581 Q5VYS8 TUT7_HUMAN 86.111 0.951488 1.03411 TUT7 - Terminal uridylyltransferase 7 - Homo sapiens (Human) - TUT7 gene Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:19703396, PubMed:22898984, PubMed:18172165, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). Indicus|evm.model.CM009498.1.583 P54826 GAS1_HUMAN 92.353 0.974138 1.0087 GAS1 - Growth arrest-specific protein 1 precursor - Homo sapiens (Human) - GAS1 gene Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. Indicus|evm.model.CM009498.1.584 A8D8X1 RL10_SHEEP 81.081 0.972603 0.341121 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009498.1.586 P53355 DAPK1_HUMAN 95.944 0.998602 1.0007 DAPK1 - Death-associated protein kinase 1 - Homo sapiens (Human) - DAPK1 gene Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition. Indicus|evm.model.CM009498.1.587 Q9GL24 CATL1_CANLF 79.042 0.902174 1.10511 CTSL - Procathepsin L precursor - Canis lupus familiaris (Dog) - CTSL gene Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity). Indicus|evm.model.CM009498.1.588 Q2KJJ9 F16P2_BOVIN 90.855 0.993528 0.911504 FBP2 - Fructose-1,6-bisphosphatase isozyme 2 - Bos taurus (Bovine) - FBP2 gene Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. Indicus|evm.model.CM009498.1.589 Q3SZB7 F16P1_BOVIN 100.000 0.9941 1.00296 FBP1 - Fructose-1,6-bisphosphatase 1 - Bos taurus (Bovine) - FBP1 gene Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Indicus|evm.model.CM009498.1.590 Q8N6M6 AMPO_HUMAN 87.253 0.998466 0.796093 AOPEP - Aminopeptidase O - Homo sapiens (Human) - AOPEP gene Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Indicus|evm.model.CM009498.1.591 O19104 FANCC_BOVIN 98.944 0.996485 1.00353 FANCC - Fanconi anemia group C protein homolog - Bos taurus (Bovine) - FANCC gene DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). Indicus|evm.model.CM009498.1.593 Q13635 PTC1_HUMAN 96.254 0.993553 0.964755 PTCH1 - Protein patched homolog 1 - Homo sapiens (Human) - PTCH1 gene Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. Indicus|evm.model.CM009498.1.597 A3KMX0 ER6L2_BOVIN 99.551 0.998717 1.00064 ERCC6L2 - DNA excision repair protein ERCC-6-like 2 - Bos taurus (Bovine) - ERCC6L2 gene May be involved in early DNA damage response. Indicus|evm.model.CM009498.1.598 P37058 DHB3_HUMAN 81.613 0.993569 1.00323 HSD17B3 - Testosterone 17-beta-dehydrogenase 3 - Homo sapiens (Human) - HSD17B3 gene Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH (PubMed:26545797, PubMed:8075637, PubMed:16216911). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911). Indicus|evm.model.CM009498.1.599 Q76EJ3 S35D2_HUMAN 91.395 0.99115 1.00593 SLC35D2 - UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter - Homo sapiens (Human) - SLC35D2 gene Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. Indicus|evm.model.CM009498.1.600 Q7RTV3 ZN367_HUMAN 92.308 0.994286 1 ZNF367 - Zinc finger protein 367 - Homo sapiens (Human) - ZNF367 gene Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. Indicus|evm.model.CM009498.1.601 Q5JVS0 HABP4_HUMAN 89.688 0.995215 1.01211 HABP4 - Intracellular hyaluronan-binding protein 4 - Homo sapiens (Human) - HABP4 gene RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Involved in mRNA translation regulation, probably at the initiation step (PubMed:21771594). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Indicus|evm.model.CM009498.1.602 O60729 CC14B_HUMAN 86.346 0.996161 1.04618 CDC14B - Dual specificity protein phosphatase CDC14B - Homo sapiens (Human) - CDC14B gene Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. Indicus|evm.model.CM009498.1.603 Q148E0 PXL2C_BOVIN 100.000 0.991266 1.00439 PRXL2C - Peroxiredoxin-like 2C - Bos taurus (Bovine) - PRXL2C gene May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. Indicus|evm.model.CM009498.1.604 P62246 RS15A_RAT 97.692 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Indicus|evm.model.CM009498.1.605 Q6ZMW2 ZN782_HUMAN 78.125 0.995733 1.00572 ZNF782 - Zinc finger protein 782 - Homo sapiens (Human) - ZNF782 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009498.1.606 P25975 CATL1_BOVIN 98.983 0.872404 1.00898 CTSL - Procathepsin L precursor - Bos taurus (Bovine) - CTSL gene Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (PubMed:12869695). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity). Indicus|evm.model.CM009498.1.609 Q5JVG2 ZN484_HUMAN 73.302 0.911475 1.07394 ZNF484 - Zinc finger protein 484 - Homo sapiens (Human) - ZNF484 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009498.1.610 P41252 SYIC_HUMAN 91.204 0.998416 1.00079 IARS1 - Isoleucine--tRNA ligase, cytoplasmic - Homo sapiens (Human) - IARS1 gene Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Indicus|evm.model.CM009498.1.611 Q76FK4 NOL8_HUMAN 73.083 0.99828 0.996572 NOL8 - Nucleolar protein 8 - Homo sapiens (Human) - NOL8 gene Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. Indicus|evm.model.CM009498.1.612 P19879 MIME_BOVIN 100.000 0.993333 1.00334 OGN - Mimecan precursor - Bos taurus (Bovine) - OGN gene Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2. Indicus|evm.model.CM009498.1.613 O77742 OMD_BOVIN 99.763 0.995272 1.00237 OMD - Osteomodulin precursor - Bos taurus (Bovine) - OMD gene May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. Indicus|evm.model.CM009498.1.614 Q3ZBN5 ASPN_BOVIN 100.000 0.994609 1.0027 ASPN - Asporin precursor - Bos taurus (Bovine) - ASPN gene extracellular space Indicus|evm.model.CM009498.1.615 Q3MHH9 ECM2_BOVIN 96.586 0.9 1.14706 ECM2 - Extracellular matrix protein 2 precursor - Bos taurus (Bovine) - ECM2 gene Promotes matrix assembly and cell adhesiveness. Indicus|evm.model.CM009498.1.616 Q6IPU0 CENPP_HUMAN 76.364 0.939655 0.402778 CENPP - Centromere protein P - Homo sapiens (Human) - CENPP gene Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Indicus|evm.model.CM009498.1.617 Q9H8X2 IPPK_HUMAN 84.200 0.995859 0.983707 IPPK - Inositol-pentakisphosphate 2-kinase - Homo sapiens (Human) - IPPK gene Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. Indicus|evm.model.CM009498.1.618 Q8TD16 BICD2_HUMAN 90.655 0.997519 0.978155 BICD2 - Protein bicaudal D homolog 2 - Homo sapiens (Human) - BICD2 gene Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). Indicus|evm.model.CM009498.1.619 Q5R5T1 FGD3_PONAB 72.848 0.997301 1.00543 FGD3 - FYVE, RhoGEF and PH domain-containing protein 3 - Pongo abelii (Sumatran orangutan) - FGD3 gene Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). Indicus|evm.model.CM009498.1.620 Q96L08 SUSD3_HUMAN 64.504 0.992218 1.00784 SUSD3 - Sushi domain-containing protein 3 - Homo sapiens (Human) - SUSD3 gene May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration. Indicus|evm.model.CM009498.1.621 Q58D91 CAR19_BOVIN 99.454 0.98913 1.00546 CARD19 - Caspase recruitment domain-containing protein 19 - Bos taurus (Bovine) - CARD19 gene Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. Indicus|evm.model.CM009498.1.622 P70617 NINJ1_RAT 88.158 0.986842 1 Ninj1 - Ninjurin-1 - Rattus norvegicus (Rat) - Ninj1 gene Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis (By similarity). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) (PubMed:19595672). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells (By similarity). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (By similarity). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (By similarity). Acts as a mediator of both programmed and necrotic cell death (By similarity). Plays a key role in the induction of plasma membrane rupture during programmed and necrotic cell death: oligomerizes in response to death stimuli to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Plays a role in nerve regeneration by promoting maturation of Schwann cells (By similarity). Acts as a regulator of angiogenesis (PubMed:33028854). Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (By similarity). Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts (By similarity). Also involved in striated muscle growth and differentiation (By similarity). Indicus|evm.model.CM009498.1.623 Q9Y3S1 WNK2_HUMAN 85.010 0.432657 0.94384 WNK2 - Serine/threonine-protein kinase WNK2 - Homo sapiens (Human) - WNK2 gene Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. Indicus|evm.model.CM009498.1.625 A6H7H1 F120A_BOVIN 99.904 0.998081 0.935368 FAM120A - Constitutive coactivator of PPAR-gamma-like protein 1 - Bos taurus (Bovine) - FAM120A gene Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May participate in mRNA transport in the cytoplasm (By similarity). Indicus|evm.model.CM009498.1.626 O75151 PHF2_HUMAN 89.646 0.993365 0.962591 PHF2 - Lysine-specific demethylase PHF2 - Homo sapiens (Human) - PHF2 gene Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Indicus|evm.model.CM009498.1.627 A5D7C3 MPZL3_BOVIN 95.000 0.975309 0.346154 MPZL3 - Myelin protein zero-like protein 3 precursor - Bos taurus (Bovine) - MPZL3 gene Mediates homophilic cell-cell adhesion. Indicus|evm.model.CM009498.1.628 Q10994 CYTB_SHEEP 77.551 0.979592 1 CSTB - Cystatin-B - Ovis aries (Sheep) - CSTB gene This is an intracellular thiol proteinase inhibitor. Indicus|evm.model.CM009498.1.629 Q9HBU1 BARX1_HUMAN 96.000 0.99115 0.889764 BARX1 - Homeobox protein BarH-like 1 - Homo sapiens (Human) - BARX1 gene Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter. Indicus|evm.model.CM009498.1.630 A7E379 PTPC1_BOVIN 99.311 0.962815 0.94598 PTPDC1 - Protein tyrosine phosphatase domain-containing protein 1 - Bos taurus (Bovine) - PTPDC1 gene May play roles in cilia formation and/or maintenance. Indicus|evm.model.CM009498.1.632 Q14929 ZN169_HUMAN 73.266 0.994614 0.923715 ZNF169 - Zinc finger protein 169 - Homo sapiens (Human) - ZNF169 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009498.1.633 Q5VT25 MRCKA_HUMAN 63.052 0.952756 0.439954 CDC42BPA - Serine/threonine-protein kinase MRCK alpha - Homo sapiens (Human) - CDC42BPA gene Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). Indicus|evm.model.CM009498.1.634 Q3MHG1 SPTC1_BOVIN 100.000 0.995781 1.00211 SPTLC1 - Serine palmitoyltransferase 1 - Bos taurus (Bovine) - SPTLC1 gene Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (By similarity). Indicus|evm.model.CM009498.1.635 Q01974 ROR2_HUMAN 93.425 0.997875 0.997879 ROR2 - Tyrosine-protein kinase transmembrane receptor ROR2 precursor - Homo sapiens (Human) - ROR2 gene Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). Indicus|evm.model.CM009498.1.636 Q08D88 NFIL3_BOVIN 100.000 0.99568 1.00216 NFIL3 - Nuclear factor interleukin-3-regulated protein - Bos taurus (Bovine) - NFIL3 gene Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). Indicus|evm.model.CM009498.1.637 Q13825 AUHM_HUMAN 80.328 0.887097 0.914454 AUH - Methylglutaconyl-CoA hydratase, mitochondrial precursor - Homo sapiens (Human) - AUH gene Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA (PubMed:11738050, PubMed:12434311, PubMed:12655555). Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Has very low enoyl-CoA hydratase activity (PubMed:7892223). Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs (PubMed:7892223). Indicus|evm.model.CM009498.1.638 Q00655 KSYK_PIG 94.904 0.99682 1.00159 SYK - Tyrosine-protein kinase SYK - Sus scrofa (Pig) - SYK gene Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Required for the stimulation of neutrophil phagocytosis by IL15 (By similarity). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). Indicus|evm.model.CM009498.1.639 Q5PR73 DIRA2_MOUSE 97.990 0.99 1.00503 Diras2 - GTP-binding protein Di-Ras2 precursor - Mus musculus (Mouse) - Diras2 gene Displays low GTPase activity and exists predominantly in the GTP-bound form. Indicus|evm.model.CM009498.1.642 Q2KIX1 GA45G_BOVIN 100.000 0.9875 1.00629 GADD45G - Growth arrest and DNA damage-inducible protein GADD45 gamma - Bos taurus (Bovine) - GADD45G gene Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity). Indicus|evm.model.CM009498.1.643 Q29361 RL35_PIG 77.273 0.954545 0.715447 RPL35 - 60S ribosomal protein L35 - Sus scrofa (Pig) - RPL35 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009498.1.644 Q92854 SEM4D_HUMAN 84.589 0.997685 1.00232 SEMA4D - Semaphorin-4D precursor - Homo sapiens (Human) - SEMA4D gene Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). Indicus|evm.model.CM009498.1.646 Q96T21 SEBP2_HUMAN 76.539 0.997633 0.989461 SECISBP2 - Selenocysteine insertion sequence-binding protein 2 - Homo sapiens (Human) - SECISBP2 gene Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB. Indicus|evm.model.CM009498.1.648 Q92529 SHC3_HUMAN 91.800 0.988713 0.745791 SHC3 - SHC-transforming protein 3 - Homo sapiens (Human) - SHC3 gene Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. Indicus|evm.model.CM009498.1.649 Q99500 S1PR3_HUMAN 88.000 0.986807 1.00265 S1PR3 - Sphingosine 1-phosphate receptor 3 - Homo sapiens (Human) - S1PR3 gene Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Indicus|evm.model.CM009498.1.650 Q5R9C3 GPBL1_PONAB 87.234 0.621622 0.156118 GPBP1L1 - Vasculin-like protein 1 - Pongo abelii (Sumatran orangutan) - GPBP1L1 gene Possible transcription factor. Indicus|evm.model.CM009498.1.651 Q5VZ03 NXNL2_HUMAN 85.806 0.980892 1.00641 NXNL2 - Nucleoredoxin-like protein 2 - Homo sapiens (Human) - NXNL2 gene May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons. Indicus|evm.model.CM009498.1.652 Q5R997 SPIN1_PONAB 99.237 0.992395 1.00382 SPIN1 - Spindlin-1 - Pongo abelii (Sumatran orangutan) - SPIN1 gene Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. Indicus|evm.model.CM009498.1.653 Q29463 TRY2_BOVIN 95.804 0.855422 0.672065 Anionic trypsin precursor - Bos taurus (Bovine) Indicus|evm.model.CM009498.1.654 P30205 WC11_BOVIN 80.909 0.495455 0.153203 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009498.1.656 Q9JHU3 CDK20_MOUSE 96.532 0.994236 1.00289 Cdk20 - Cyclin-dependent kinase 20 - Mus musculus (Mouse) - Cdk20 gene Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Indicus|evm.model.CM009498.1.659 Q86Y26 NUTM1_HUMAN 59.740 0.670753 0.504417 NUTM1 - NUT family member 1 - Homo sapiens (Human) - NUTM1 gene Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. Indicus|evm.model.CM009498.1.661 A5PJI6 CAVN4_BOVIN 100.000 0.994475 1.00277 CAVIN4 - Caveolae-associated protein 4 - Bos taurus (Bovine) - CAVIN4 gene Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes. Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway. Indicus|evm.model.CM009498.1.662 Q8TBJ4 PLPR1_HUMAN 92.537 0.709677 0.286154 PLPPR1 - Phospholipid phosphatase-related protein type 1 - Homo sapiens (Human) - PLPPR1 gene integral component of plasma membrane, nucleoplasm, lipid phosphatase activity, phosphatidate phosphatase activity, phospholipid dephosphorylation, phospholipid metabolic process, signal transduction Indicus|evm.model.CM009498.1.663 Q8TBJ4 PLPR1_HUMAN 98.930 0.756098 0.756923 PLPPR1 - Phospholipid phosphatase-related protein type 1 - Homo sapiens (Human) - PLPPR1 gene integral component of plasma membrane, nucleoplasm, lipid phosphatase activity, phosphatidate phosphatase activity, phospholipid dephosphorylation, phospholipid metabolic process, signal transduction Indicus|evm.model.CM009498.1.664 Q5FVR5 ACNT2_RAT 65.871 0.995238 1.00478 Acnat2 - Acyl-coenzyme A amino acid N-acyltransferase 2 - Rattus norvegicus (Rat) - Acnat2 gene Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity). Indicus|evm.model.CM009498.1.665 Q63276 BAAT_RAT 70.149 0.857143 0.183333 Baat - Bile acid-CoA:amino acid N-acyltransferase - Rattus norvegicus (Rat) - Baat gene Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PubMed:12951368, PubMed:624713). More efficient at taurine conjugation of cholyl CoA than glycine conjugation (PubMed:12951368, PubMed:624713). Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (By similarity). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (By similarity). In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (By similarity). Indicus|evm.model.CM009498.1.666 Q2KI49 RM50_BOVIN 100.000 0.9875 1.00629 MRPL50 - 39S ribosomal protein L50, mitochondrial - Bos taurus (Bovine) - MRPL50 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Indicus|evm.model.CM009498.1.667 O75820 ZN189_HUMAN 95.687 0.996737 0.979233 ZNF189 - Zinc finger protein 189 - Homo sapiens (Human) - ZNF189 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009498.1.668 Q3T0S5 ALDOB_BOVIN 99.451 0.994521 1.00275 ALDOB - Fructose-bisphosphate aldolase B - Bos taurus (Bovine) - ALDOB gene cytosol, fructose-1-phosphate aldolase activity, fructose-bisphosphate aldolase activity, fructose 1,6-bisphosphate metabolic process, glycolytic process Indicus|evm.model.CM009498.1.670 Q9BRR3 PGAP4_HUMAN 99.504 0.99505 1.00248 PGAP4 - Post-GPI attachment to proteins factor 4 - Homo sapiens (Human) - PGAP4 gene Golgi-resident glycosylphosphatidylinositol (GPI)-N-acetylgalactosamine transferase involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins (PubMed:29374258). Required for the initial step of GPI-GalNAc biosynthesis, transfers GalNAc to GPI in the Golgi after fatty acid remodeling by PGAP2 (PubMed:29374258). Indicus|evm.model.CM009498.1.671 A2VDP1 BRE1A_BOVIN 100.000 0.997951 1.00103 RNF20 - E3 ubiquitin-protein ligase BRE1A - Bos taurus (Bovine) - RNF20 gene Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of PA2G4 leading to its proteasome-mediated degradation. Indicus|evm.model.CM009498.1.672 Q8TCU5 NMD3A_HUMAN 86.935 0.71223 0.249327 GRIN3A - Glutamate receptor ionotropic, NMDA 3A precursor - Homo sapiens (Human) - GRIN3A gene NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism. Indicus|evm.model.CM009498.1.673 Q2TBI5 CANB2_BOVIN 99.412 0.988304 1.00588 PPP3R2 - Calcineurin subunit B type 2 - Bos taurus (Bovine) - PPP3R2 gene Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Indicus|evm.model.CM009498.1.674 Q8TCU5 NMD3A_HUMAN 94.486 0.992481 0.834978 GRIN3A - Glutamate receptor ionotropic, NMDA 3A precursor - Homo sapiens (Human) - GRIN3A gene NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism. Indicus|evm.model.CM009498.1.675 Q99877 H2B1N_HUMAN 93.043 0.95 0.952381 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009498.1.676 Q28092 CYLC2_BOVIN 95.904 0.772487 0.77459 CYLC2 - Cylicin-2 - Bos taurus (Bovine) - CYLC2 gene Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. Indicus|evm.model.CM009498.1.678 P62630 EF1A1_RAT 100.000 0.862903 0.268398 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009498.1.679 O95347 SMC2_HUMAN 93.115 0.998322 0.995823 SMC2 - Structural maintenance of chromosomes protein 2 - Homo sapiens (Human) - SMC2 gene Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Indicus|evm.model.CM009498.1.681 Q5RAA9 NPS3A_PONAB 91.093 0.991935 1.00405 NIPSNAP3A - Protein NipSnap homolog 3A - Pongo abelii (Sumatran orangutan) - NIPSNAP3A gene Indicus|evm.model.CM009498.1.682 O95477 ABCA1_HUMAN 75.510 0.311688 0.0681115 ABCA1 - Phospholipid-transporting ATPase ABCA1 - Homo sapiens (Human) - ABCA1 gene Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Thereby, participates in phospholipid transfer to apoliproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981). Indicus|evm.model.CM009498.1.683 O95477 ABCA1_HUMAN 94.646 0.959643 1.04113 ABCA1 - Phospholipid-transporting ATPase ABCA1 - Homo sapiens (Human) - ABCA1 gene Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Thereby, participates in phospholipid transfer to apoliproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981). Indicus|evm.model.CM009498.1.684 P46777 RL5_HUMAN 77.640 0.952381 0.565657 RPL5 - 60S ribosomal protein L5 - Homo sapiens (Human) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Indicus|evm.model.CM009498.1.685 Q58DW5 RL5_BOVIN 69.565 0.94 0.673401 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Indicus|evm.model.CM009498.1.686 Q8WWI5 CTL1_HUMAN 94.400 0.885714 0.21309 SLC44A1 - Choline transporter-like protein 1 - Homo sapiens (Human) - SLC44A1 gene Choline transporter. Involved in membrane synthesis and myelin production. Indicus|evm.model.CM009498.1.687 Q8WWI5 CTL1_HUMAN 85.199 0.878594 0.476408 SLC44A1 - Choline transporter-like protein 1 - Homo sapiens (Human) - SLC44A1 gene Choline transporter. Involved in membrane synthesis and myelin production. Indicus|evm.model.CM009498.1.688 Q8WWI5 CTL1_HUMAN 97.927 0.969697 0.30137 SLC44A1 - Choline transporter-like protein 1 - Homo sapiens (Human) - SLC44A1 gene Choline transporter. Involved in membrane synthesis and myelin production. Indicus|evm.model.CM009498.1.689 Q9BXM9 FSD1L_HUMAN 96.349 0.987952 0.939623 FSD1L - FSD1-like protein - Homo sapiens (Human) - FSD1L gene Indicus|evm.model.CM009498.1.690 O75072 FKTN_HUMAN 90.909 0.99568 1.00434 FKTN - Fukutin - Homo sapiens (Human) - FKTN gene Catalyzes the transfer of CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:17034757). May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:25279699). Could be involved in brain development (Probable). Indicus|evm.model.CM009498.1.691 Q0VC58 TM38B_BOVIN 100.000 0.993151 1.00344 TMEM38B - Trimeric intracellular cation channel type B - Bos taurus (Bovine) - TMEM38B gene Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Indicus|evm.model.CM009498.1.693 Q58DT1 RL7_BOVIN 90.826 0.972973 0.447581 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Indicus|evm.model.CM009498.1.695 Q96JM2 ZN462_HUMAN 94.937 0.765388 0.998404 ZNF462 - Zinc finger protein 462 - Homo sapiens (Human) - ZNF462 gene Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). Indicus|evm.model.CM009498.1.696 Q29RK4 RD23B_BOVIN 100.000 0.99511 1.00245 RAD23B - UV excision repair protein RAD23 homolog B - Bos taurus (Bovine) - RAD23B gene Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity). Indicus|evm.model.CM009498.1.697 Q60793 KLF4_MOUSE 92.798 0.995893 1.00828 Klf4 - Krueppel-like factor 4 - Mus musculus (Mouse) - Klf4 gene Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity). Indicus|evm.model.CM009498.1.698 P81795 IF2G_RAT 98.473 0.938849 0.588983 Eif2s3 - Eukaryotic translation initiation factor 2 subunit 3, X-linked - Rattus norvegicus (Rat) - Eif2s3 gene As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). Indicus|evm.model.CM009498.1.699 Q2KHU8 IF2G_BOVIN 96.429 0.834586 0.28178 EIF2S3 - Eukaryotic translation initiation factor 2 subunit 3 - Bos taurus (Bovine) - EIF2S3 gene As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). Indicus|evm.model.CM009498.1.700 P20821 GCSH_BOVIN 92.373 0.959016 0.705202 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Indicus|evm.model.CM009498.1.701 Q32L91 ACL7B_BOVIN 100.000 0.995215 1.0024 ACTL7B - Actin-like protein 7B - Bos taurus (Bovine) - ACTL7B gene cytoplasm, dynactin complex, nucleus Indicus|evm.model.CM009498.1.702 Q32KZ2 ACL7A_BOVIN 97.895 0.737354 1.17352 ACTL7A - Actin-like protein 7A - Bos taurus (Bovine) - ACTL7A gene cytoplasm, dynactin complex, nucleus Indicus|evm.model.CM009498.1.703 Q8WND5 ELP1_RABIT 86.276 0.963651 0.928732 ELP1 - Elongator complex protein 1 - Oryctolagus cuniculus (Rabbit) - ELP1 gene Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity). Indicus|evm.model.CM009498.1.704 Q29S16 ABITM_BOVIN 100.000 0.989362 1.00535 ABITRAM - Protein Abitram - Bos taurus (Bovine) - ABITRAM gene Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons. May play a role in transcription regulation. Indicus|evm.model.CM009498.1.705 Q5RC06 CTNL1_PONAB 91.877 0.997203 0.974114 CTNNAL1 - Alpha-catulin - Pongo abelii (Sumatran orangutan) - CTNNAL1 gene May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). Indicus|evm.model.CM009498.1.706 E1BD52 TM245_BOVIN 99.539 0.981818 1.01382 TMEM245 - Transmembrane protein 245 - Bos taurus (Bovine) - TMEM245 gene Indicus|evm.model.CM009498.1.707 Q9P0K9 FRS1L_HUMAN 97.696 0.943231 0.665698 FRRS1L - DOMON domain-containing protein FRRS1L - Homo sapiens (Human) - FRRS1L gene Important modulator of glutamate signaling pathway. Indicus|evm.model.CM009498.1.708 B2RYE5 E41LB_RAT 97.011 0.455901 1.52751 Epb41l4b - Band 4.1-like protein 4B - Rattus norvegicus (Rat) - Epb41l4b gene Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18. Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing. May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation. Indicus|evm.model.CM009498.1.709 P26045 PTN3_HUMAN 91.005 0.997884 1.03505 PTPN3 - Tyrosine-protein phosphatase non-receptor type 3 - Homo sapiens (Human) - PTPN3 gene May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Indicus|evm.model.CM009498.1.711 Q8IXS6 PALM2_HUMAN 96.947 0.119595 2.86807 PALM2 - Paralemmin-2 precursor - Homo sapiens (Human) - PALM2 gene Indicus|evm.model.CM009498.1.712 Q5JTZ5 CI152_HUMAN 68.201 0.991489 0.983264 C9orf152 - Uncharacterized protein C9orf152 - Homo sapiens (Human) - C9orf152 gene Indicus|evm.model.CM009498.1.713 O97680 THIO_BOVIN 98.000 0.469194 2.00952 TXN - Thioredoxin - Bos taurus (Bovine) - TXN gene Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). Indicus|evm.model.CM009498.1.714 Q6A555 TXND8_HUMAN 55.118 0.981132 0.834646 TXNDC8 - Thioredoxin domain-containing protein 8 - Homo sapiens (Human) - TXNDC8 gene May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm. Indicus|evm.model.CM009498.1.715 Q4LDE5 SVEP1_HUMAN 84.299 0.999432 0.985438 SVEP1 - Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor - Homo sapiens (Human) - SVEP1 gene May play a role in the cell attachment process. Indicus|evm.model.CM009498.1.716 O15146 MUSK_HUMAN 89.183 0.997579 0.950518 MUSK - Muscle, skeletal receptor tyrosine-protein kinase precursor - Homo sapiens (Human) - MUSK gene Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). Indicus|evm.model.CM009498.1.717 P46628 LPAR1_SHEEP 99.174 0.991781 0.928753 LPAR1 - Lysophosphatidic acid receptor 1 - Ovis aries (Sheep) - LPAR1 gene Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain. Indicus|evm.model.CM009498.1.718 Q5VYK3 ECM29_HUMAN 96.563 0.995111 0.997832 ECPAS - Proteasome adapter and scaffold protein ECM29 - Homo sapiens (Human) - ECPAS gene Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). Indicus|evm.model.CM009498.1.719 Q8TF39 ZN483_HUMAN 78.042 0.997354 1.01613 ZNF483 - Zinc finger protein 483 - Homo sapiens (Human) - ZNF483 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009498.1.720 Q3SZJ4 PTGR1_BOVIN 99.392 0.87234 1.14286 PTGR1 - Prostaglandin reductase 1 - Bos taurus (Bovine) - PTGR1 gene NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (By similarity). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). Indicus|evm.model.CM009498.1.721 Q9H1X3 DJC25_HUMAN 92.222 0.994444 1 DNAJC25 - DnaJ homolog subfamily C member 25 - Homo sapiens (Human) - DNAJC25 gene endoplasmic reticulum membrane, protein folding Indicus|evm.model.CM009498.1.722 P50151 GBG10_HUMAN 98.529 0.971014 1.01471 GNG10 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 precursor - Homo sapiens (Human) - GNG10 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3. Indicus|evm.model.CM009498.1.723 Q5VXU9 SHOC1_HUMAN 73.371 0.998583 0.977147 SHOC1 - Protein shortage in chiasmata 1 ortholog - Homo sapiens (Human) - SHOC1 gene ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (PubMed:29742103). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (PubMed:29742103). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (By similarity). Requiref for recruitment TEX11 and MSH4 to recombination intermediates (By similarity). Indicus|evm.model.CM009498.1.724 Q16739 CEGT_HUMAN 99.746 0.994937 1.00254 UGCG - Ceramide glucosyltransferase - Homo sapiens (Human) - UGCG gene Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (PubMed:8643456, PubMed:1532799). Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (PubMed:8643456). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction. They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway. They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope. The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity). Indicus|evm.model.CM009498.1.725 Q6UWL2 SUSD1_HUMAN 82.485 0.921271 0.96921 SUSD1 - Sushi domain-containing protein 1 precursor - Homo sapiens (Human) - SUSD1 gene Indicus|evm.model.CM009498.1.726 O95758 PTBP3_HUMAN 96.117 0.601874 1.5471 PTBP3 - Polypyrimidine tract-binding protein 3 - Homo sapiens (Human) - PTBP3 gene RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). Indicus|evm.model.CM009498.1.727 A4FUZ6 HSDL2_BOVIN 99.761 0.995227 1.00239 HSDL2 - Hydroxysteroid dehydrogenase-like protein 2 - Bos taurus (Bovine) - HSDL2 gene Has apparently no steroid dehydrogenase activity. Indicus|evm.model.CM009498.1.728 Q8N8K9 K1958_HUMAN 63.636 0.910569 1.03073 KIAA1958 - Uncharacterized protein KIAA1958 - Homo sapiens (Human) - KIAA1958 gene Indicus|evm.model.CM009498.1.729 Q8N8K9 K1958_HUMAN 96.626 0.936599 0.484637 KIAA1958 - Uncharacterized protein KIAA1958 - Homo sapiens (Human) - KIAA1958 gene Indicus|evm.model.CM009498.1.730 Q2NKT2 SOSSC_BOVIN 100.000 0.980952 1.00962 INIP - SOSS complex subunit C - Bos taurus (Bovine) - INIP gene Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). Indicus|evm.model.CM009498.1.731 Q5VWJ9 SNX30_HUMAN 96.110 0.995434 1.00229 SNX30 - Sorting nexin-30 - Homo sapiens (Human) - SNX30 gene May be involved in several stages of intracellular trafficking. Indicus|evm.model.CM009498.1.732 Q866G7 TSCOT_CANLF 81.646 0.802426 1.19958 SLC46A2 - Thymic stromal cotransporter homolog - Canis lupus familiaris (Dog) - SLC46A2 gene May act as a transporter (By similarity). May be involved in establishing and maintaining the luminal fluid microenvironment. Indicus|evm.model.CM009498.1.733 Q95182 ALL1_HORSE 65.946 0.989071 0.97861 Major allergen Equ c 1 precursor - Equus caballus (Horse) Indicus|evm.model.CM009498.1.734 Q95182 ALL1_HORSE 64.865 0.989011 0.973262 Major allergen Equ c 1 precursor - Equus caballus (Horse) Indicus|evm.model.CM009498.1.735 Q9Y6Q3 ZFP37_HUMAN 78.516 0.99685 1.00794 ZFP37 - Zinc finger protein 37 homolog - Homo sapiens (Human) - ZFP37 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009498.1.739 O15432 COPT2_HUMAN 78.014 0.972222 1.00699 SLC31A2 - Probable low affinity copper uptake protein 2 - Homo sapiens (Human) - SLC31A2 gene Involved in low-affinity copper uptake. Indicus|evm.model.CM009498.1.740 Q5T1M5 FKB15_HUMAN 82.093 0.998325 0.979491 FKBP15 - FK506-binding protein 15 - Homo sapiens (Human) - FKBP15 gene May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. Indicus|evm.model.CM009498.1.741 Q8K211 COPT1_MOUSE 93.714 0.905263 0.969388 Slc31a1 - High affinity copper uptake protein 1 - Mus musculus (Mouse) - Slc31a1 gene High-affinity, saturable copper transporter involved in dietary copper uptake. Indicus|evm.model.CM009498.1.742 Q3SZT7 CDC26_BOVIN 100.000 0.792453 1.24706 CDC26 - Anaphase-promoting complex subunit CDC26 - Bos taurus (Bovine) - CDC26 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). Indicus|evm.model.CM009498.1.743 Q3MHE2 PRP4_BOVIN 100.000 0.996169 1.00192 PRPF4 - U4/U6 small nuclear ribonucleoprotein Prp4 - Bos taurus (Bovine) - PRPF4 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). Indicus|evm.model.CM009498.1.745 Q3SWY0 RN183_BOVIN 100.000 0.769547 1.29255 RNF183 - E3 ubiquitin-protein ligase RNF183 - Bos taurus (Bovine) - RNF183 gene Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling. Indicus|evm.model.CM009498.1.746 Q8NA23 WDR31_HUMAN 86.376 0.861176 1.15804 WDR31 - WD repeat-containing protein 31 - Homo sapiens (Human) - WDR31 gene Indicus|evm.model.CM009498.1.747 Q5W0U4 BSPRY_HUMAN 89.526 0.992556 1.00249 BSPRY - B box and SPRY domain-containing protein - Homo sapiens (Human) - BSPRY gene May regulate epithelial calcium transport by inhibiting TRPV5 activity. Indicus|evm.model.CM009498.1.748 Q5E9D6 HDHD3_BOVIN 98.805 0.992063 1.00398 HDHD3 - Haloacid dehalogenase-like hydrolase domain-containing protein 3 - Bos taurus (Bovine) - HDHD3 gene Indicus|evm.model.CM009498.1.749 Q58DK5 HEM2_BOVIN 100.000 0.993939 1.00304 ALAD - Delta-aminolevulinic acid dehydratase - Bos taurus (Bovine) - ALAD gene Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). Indicus|evm.model.CM009498.1.750 Q5R4W3 DPOE3_PONAB 100.000 0.986486 1.0068 POLE3 - DNA polymerase epsilon subunit 3 - Pongo abelii (Sumatran orangutan) - POLE3 gene Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). Indicus|evm.model.CM009498.1.751 Q8TAL5 CI043_HUMAN 55.765 0.947712 0.995662 C9orf43 - Uncharacterized protein C9orf43 - Homo sapiens (Human) - C9orf43 gene Indicus|evm.model.CM009498.1.752 P49796 RGS3_HUMAN 86.321 0.98226 0.89399 RGS3 - Regulator of G-protein signaling 3 - Homo sapiens (Human) - RGS3 gene Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. Indicus|evm.model.CM009498.1.753 P46405 RS12_PIG 60.902 0.98 0.757576 RPS12 - 40S ribosomal protein S12 - Sus scrofa (Pig) - RPS12 gene cytosolic small ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009498.1.754 Q80YY7 ZN618_MOUSE 89.534 0.886775 1.10283 Znf618 - Zinc finger protein 618 - Mus musculus (Mouse) - Znf618 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009498.1.755 P00978 AMBP_BOVIN 98.864 0.420359 2.37216 AMBP - Protein AMBP precursor - Bos taurus (Bovine) - AMBP gene Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. Indicus|evm.model.CM009498.1.756 Q8IZC6 CORA1_HUMAN 86.453 0.486339 0.787097 COL27A1 - Collagen alpha-1(XXVII) chain precursor - Homo sapiens (Human) - COL27A1 gene Plays a role during the calcification of cartilage and the transition of cartilage to bone. Indicus|evm.model.CM009498.1.757 Q3SZR3 A1AG_BOVIN 99.505 0.990148 1.00495 ORM1 - Alpha-1-acid glycoprotein precursor - Bos taurus (Bovine) - ORM1 gene Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction (By similarity). Indicus|evm.model.CM009498.1.758 Q7Z591 AKNA_HUMAN 75.839 0.112719 0.912439 AKNA - Microtubule organization protein AKNA - Homo sapiens (Human) - AKNA gene Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). Indicus|evm.model.CM009498.1.759 Q9P202 WHRN_HUMAN 91.045 0.95815 1.0011 WHRN - Whirlin - Homo sapiens (Human) - WHRN gene Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Indicus|evm.model.CM009498.1.760 P79251 VATG1_BOVIN 100.000 0.983193 1.00847 ATP6V1G1 - V-type proton ATPase subunit G 1 - Bos taurus (Bovine) - ATP6V1G1 gene Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). Indicus|evm.model.CM009498.1.761 Q5EA48 TM268_BOVIN 99.709 0.830508 1.20058 TMEM268 - Transmembrane protein 268 - Bos taurus (Bovine) - TMEM268 gene Indicus|evm.model.CM009498.1.762 O95150 TNF15_HUMAN 80.934 0.992218 1.0239 TNFSF15 - Tumor necrosis factor ligand superfamily member 15 - Homo sapiens (Human) - TNFSF15 gene Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Indicus|evm.model.CM009498.1.763 P32971 TNFL8_HUMAN 80.769 0.991489 1.00427 TNFSF8 - Tumor necrosis factor ligand superfamily member 8 - Homo sapiens (Human) - TNFSF8 gene Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. Indicus|evm.model.CM009498.1.764 Q80YX1 TENA_MOUSE 77.915 0.999053 1.00047 Tnc - Tenascin precursor - Mus musculus (Mouse) - Tnc gene Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). Indicus|evm.model.CM009498.1.766 Q13219 PAPP1_HUMAN 84.471 0.949833 0.918869 PAPPA - Pappalysin-1 precursor - Homo sapiens (Human) - PAPPA gene Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Indicus|evm.model.CM009498.1.767 O75129 ASTN2_HUMAN 98.736 0.997895 0.709485 ASTN2 - Astrotactin-2 precursor - Homo sapiens (Human) - ASTN2 gene Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6). Indicus|evm.model.CM009498.1.768 Q9GL65 TLR4_BOVIN 99.881 0.997625 1.00119 TLR4 - Toll-like receptor 4 precursor - Bos taurus (Bovine) - TLR4 gene Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:17559944). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity). Activated by the signaling pathway regulator NMI which acts as damage-associated molecular patterns (DAMPs) in response to cell injury or pathogen invasion, therefore promoting nuclear factor NF-kappa-B activation (By similarity). Indicus|evm.model.CM009498.1.771 Q5E9L2 BRNP1_BOVIN 100.000 0.997375 1.00131 BRINP1 - BMP/retinoic acid-inducible neural-specific protein 1 precursor - Bos taurus (Bovine) - BRINP1 gene Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway (By similarity). Indicus|evm.model.CM009498.1.775 Q9BE52 CK5P2_MACFA 80.769 0.04 2.23318 CDK5RAP2 - CDK5 regulatory subunit-associated protein 2 - Macaca fascicularis (Crab-eating macaque) - CDK5RAP2 gene Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (By similarity). In complex with PDE4DIP, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery. Required for the recruitment of AKAP9 to centrosomes (By similarity). Plays a role in neurogenesis (By similarity). Indicus|evm.model.CM009498.1.776 Q9H1U4 MEGF9_HUMAN 87.313 0.813387 0.818937 MEGF9 - Multiple epidermal growth factor-like domains protein 9 precursor - Homo sapiens (Human) - MEGF9 gene basement membrane, animal organ morphogenesis, cell migration, substrate adhesion-dependent cell spreading, tissue development Indicus|evm.model.CM009498.1.777 Q58D00 FBXW2_BOVIN 100.000 0.886497 1.12555 FBXW2 - F-box/WD repeat-containing protein 2 - Bos taurus (Bovine) - FBXW2 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009498.1.778 A8MXE2 B3GT9_HUMAN 83.226 0.993569 0.842818 B3GALT9 - Beta-1,3-galactosyltransferase 9 - Homo sapiens (Human) - B3GALT9 gene Putative glycosyltransferase that could catalyze the transfer of galactose residues from UDP-alpha-D-galactose. Indicus|evm.model.CM009498.1.779 Q0P5A6 PSMD5_BOVIN 99.802 0.99604 1.00398 PSMD5 - 26S proteasome non-ATPase regulatory subunit 5 - Bos taurus (Bovine) - PSMD5 gene Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity). Indicus|evm.model.CM009498.1.780 Q7T3C3 CUTA_DANRE 52.672 0.640394 1.35333 cuta - Protein CutA homolog precursor - Danio rerio (Zebrafish) - cuta gene copper ion binding Indicus|evm.model.CM009498.1.781 Q5T6S3 PHF19_HUMAN 97.069 0.996558 1.00172 PHF19 - PHD finger protein 19 - Homo sapiens (Human) - PHF19 gene Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:23104054, PubMed:31959557). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832). Indicus|evm.model.CM009498.1.782 Q13077 TRAF1_HUMAN 88.221 0.995192 1 TRAF1 - TNF receptor-associated factor 1 - Homo sapiens (Human) - TRAF1 gene Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Indicus|evm.model.CM009498.1.784 P01031 CO5_HUMAN 78.804 0.996982 0.988663 C5 - Complement C5 precursor - Homo sapiens (Human) - C5 gene Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Indicus|evm.model.CM009498.1.785 Q7Z7A1 CNTRL_HUMAN 84.294 0.99101 1.00473 CNTRL - Centriolin - Homo sapiens (Human) - CNTRL gene Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. Indicus|evm.model.CM009498.1.786 Q5R8Z8 RAB14_PONAB 100.000 0.990741 1.00465 RAB14 - Ras-related protein Rab-14 - Pongo abelii (Sumatran orangutan) - RAB14 gene Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Indicus|evm.model.CM009498.1.789 Q3SX14 GELS_BOVIN 99.863 0.974633 1.02462 GSN - Gelsolin - Bos taurus (Bovine) - GSN gene Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). Indicus|evm.model.CM009498.1.790 P27105 STOM_HUMAN 92.982 0.84273 1.17014 STOM - Stomatin - Homo sapiens (Human) - STOM gene Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. Indicus|evm.model.CM009498.1.793 A8MYV0 DCD2C_HUMAN 55.738 0.659341 0.5 DCDC2C - Doublecortin domain-containing protein 2C - Homo sapiens (Human) - DCDC2C gene cytoplasm, microtubule, microtubule organizing center, sperm flagellum Indicus|evm.model.CM009498.1.794 Q2KIG4 ALLC_BOVIN 100.000 0.995157 1.00243 ALLC - Probable allantoicase - Bos taurus (Bovine) - ALLC gene The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. Indicus|evm.model.CM009498.1.795 Q17QH6 COL11_BOVIN 100.000 0.992537 1.00375 COLEC11 - Collectin-11 precursor - Bos taurus (Bovine) - COLEC11 gene Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis. Indicus|evm.model.CM009498.1.796 P62083 RS7_RAT 100.000 0.885321 1.12371 Rps7 - 40S ribosomal protein S7 - Rattus norvegicus (Rat) - Rps7 gene Required for rRNA maturation. Indicus|evm.model.CM009498.1.797 O60930 RNH1_HUMAN 67.791 0.993769 1.12238 RNASEH1 - Ribonuclease H1 - Homo sapiens (Human) - RNASEH1 gene Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224). Indicus|evm.model.CM009498.1.798 Q3ZBL1 MTND_BOVIN 100.000 0.988889 1.00559 ADI1 - 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase - Bos taurus (Bovine) - ADI1 gene Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Indicus|evm.model.CM009498.1.799 Q8K2L8 TPC12_MOUSE 75.439 0.997468 0.991217 Trappc12 - Trafficking protein particle complex subunit 12 - Mus musculus (Mouse) - Trappc12 gene Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores. Indicus|evm.model.CM009498.1.800 Q53HC9 EIPR1_HUMAN 88.889 0.994845 1.00258 EIPR1 - EARP and GARP complex-interacting protein 1 - Homo sapiens (Human) - EIPR1 gene Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein(PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity). Indicus|evm.model.CM009499.1.3 Q2TL32 UBR4_RAT 87.719 0.622222 0.0173277 Ubr4 - E3 ubiquitin-protein ligase UBR4 - Rattus norvegicus (Rat) - Ubr4 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation (By similarity). Indicus|evm.model.CM009499.1.5 P19633 CASQ1_RAT 79.111 0.919811 0.522167 Casq1 - Calsequestrin-1 precursor - Rattus norvegicus (Rat) - Casq1 gene Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:8042990). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). Indicus|evm.model.CM009499.1.6 Q78EG7 TP4A1_RAT 98.266 0.988506 1.00578 Ptp4a1 - Protein tyrosine phosphatase type IVA 1 precursor - Rattus norvegicus (Rat) - Ptp4a1 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). Indicus|evm.model.CM009499.1.7 Q92576 PHF3_HUMAN 82.413 0.978723 1.01422 PHF3 - PHD finger protein 3 - Homo sapiens (Human) - PHF3 gene multicellular organism development Indicus|evm.model.CM009499.1.8 Q0IIG8 RAB18_BOVIN 97.087 0.990338 1.00485 RAB18 - Ras-related protein Rab-18 precursor - Bos taurus (Bovine) - RAB18 gene Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (By similarity). Indicus|evm.model.CM009499.1.9 Q96J02 ITCH_HUMAN 94.796 0.370474 0.795127 ITCH - E3 ubiquitin-protein ligase Itchy homolog - Homo sapiens (Human) - ITCH gene Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14602072, PubMed:17028573, PubMed:16387660, PubMed:18718448, PubMed:18718449, PubMed:11046148, PubMed:19592251, PubMed:19116316, PubMed:19881509, PubMed:20491914, PubMed:20392206, PubMed:20068034, PubMed:23146885, PubMed:24790097, PubMed:25631046). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response (PubMed:18718448, PubMed:20491914). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (PubMed:20068034). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Inhibits the replication of influenza A virus (IAV) via ubiquitination of IAV matrix protein 1 (M1) through 'Lys-48'-linked conjugation resulting in M1 proteasomal degradation (PubMed:30328013). Indicus|evm.model.CM009499.1.11 Q9BUJ2 HNRL1_HUMAN 68.182 0.831169 0.0899533 HNRNPUL1 - Heterogeneous nuclear ribonucleoprotein U-like protein 1 - Homo sapiens (Human) - HNRNPUL1 gene Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. Indicus|evm.model.CM009499.1.12 Q02377 NDUA1_BOVIN 94.000 0.960784 0.728571 NDUFA1 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 - Bos taurus (Bovine) - NDUFA1 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009499.1.13 Q6DG32 S2536_DANRE 83.333 0.337209 0.276527 slc25a36a - Solute carrier family 25 member 36-A - Danio rerio (Zebrafish) - slc25a36a gene pyrimidine nucleotide transmembrane transporter activity, pyrimidine nucleotide import into mitochondrion Indicus|evm.model.CM009499.1.14 P61078 UB2D3_RAT 97.279 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009499.1.15 Q80ZF8 AGRB3_MOUSE 96.721 0.659341 0.0597898 Adgrb3 - Adhesion G protein-coupled receptor B3 precursor - Mus musculus (Mouse) - Adgrb3 gene Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (PubMed:23628982). Promotes myoblast fusion through ELMO/DOCK1 (By similarity). Indicus|evm.model.CM009499.1.16 P07802 KAP0_PIG 71.552 0.877863 0.344737 PRKAR1A - cAMP-dependent protein kinase type I-alpha regulatory subunit - Sus scrofa (Pig) - PRKAR1A gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Indicus|evm.model.CM009499.1.19 P68105 EF1A1_RABIT 90.476 0.995595 0.982684 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009499.1.21 O60242 AGRB3_HUMAN 98.129 0.997126 0.457293 ADGRB3 - Adhesion G protein-coupled receptor B3 precursor - Homo sapiens (Human) - ADGRB3 gene Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399). Indicus|evm.model.CM009499.1.22 Q5E9E2 MYL9_BOVIN 80.172 0.876923 0.755814 MYL9 - Myosin regulatory light polypeptide 9 - Bos taurus (Bovine) - MYL9 gene Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). Indicus|evm.model.CM009499.1.23 Q3SYY9 LMBD1_BOVIN 99.786 0.995736 0.86372 LMBRD1 - Lysosomal cobalamin transport escort protein LMBD1 - Bos taurus (Bovine) - LMBRD1 gene Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity). Indicus|evm.model.CM009499.1.24 Q14993 COJA1_HUMAN 66.667 0.849315 0.255692 COL19A1 - Collagen alpha-1(XIX) chain precursor - Homo sapiens (Human) - COL19A1 gene May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. Indicus|evm.model.CM009499.1.25 Q14993 COJA1_HUMAN 88.948 0.929024 0.690893 COL19A1 - Collagen alpha-1(XIX) chain precursor - Homo sapiens (Human) - COL19A1 gene May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. Indicus|evm.model.CM009499.1.26 P20849 CO9A1_HUMAN 90.385 0.306509 0.917481 COL9A1 - Collagen alpha-1(IX) chain precursor - Homo sapiens (Human) - COL9A1 gene Structural component of hyaline cartilage and vitreous of the eye. Indicus|evm.model.CM009499.1.27 Q99880 H2B1L_HUMAN 88.889 0.984252 1.00794 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009499.1.28 Q9P2D6 F135A_HUMAN 86.472 0.998706 1.0198 FAM135A - Protein FAM135A - Homo sapiens (Human) - FAM135A gene cellular lipid metabolic process Indicus|evm.model.CM009499.1.29 Q5VUM1 SDHF4_HUMAN 81.481 0.981308 0.990741 SDHAF4 - Succinate dehydrogenase assembly factor 4, mitochondrial precursor - Homo sapiens (Human) - SDHAF4 gene Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity). Indicus|evm.model.CM009499.1.30 Q8IYB5 SMAP1_HUMAN 84.988 0.930886 0.991435 SMAP1 - Stromal membrane-associated protein 1 - Homo sapiens (Human) - SMAP1 gene GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity). Indicus|evm.model.CM009499.1.31 Q9NPZ5 B3GA2_HUMAN 98.425 0.728324 0.535604 B3GAT2 - Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 - Homo sapiens (Human) - B3GAT2 gene Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Indicus|evm.model.CM009499.1.32 Q5CAZ6 B3GA2_CANLF 80.095 0.821429 0.765957 B3GAT2 - Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 - Canis lupus familiaris (Dog) - B3GAT2 gene Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Indicus|evm.model.CM009499.1.33 Q5TC84 OGRL1_HUMAN 82.927 0.973475 0.83592 OGFRL1 - Opioid growth factor receptor-like protein 1 - Homo sapiens (Human) - OGFRL1 gene Indicus|evm.model.CM009499.1.35 Q9JK45 KCNQ5_MOUSE 95.745 0.511111 0.096463 Kcnq5 - Potassium voltage-gated channel subfamily KQT member 5 - Mus musculus (Mouse) - Kcnq5 gene Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Indicus|evm.model.CM009499.1.38 Q9NR82 KCNQ5_HUMAN 86.542 0.766257 0.610515 KCNQ5 - Potassium voltage-gated channel subfamily KQT member 5 - Homo sapiens (Human) - KCNQ5 gene Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. Indicus|evm.model.CM009499.1.39 Q5JSQ8 KHDCL_HUMAN 49.275 0.644231 0.8125 KHDC1L - Putative KHDC1-like protein - Homo sapiens (Human) - KHDC1L gene cytoplasm, RNA binding, activation of cysteine-type endopeptidase activity involved in apoptotic process Indicus|evm.model.CM009499.1.41 Q587J8 KHDC3_HUMAN 60.181 0.827068 1.22581 KHDC3L - KH domain-containing protein 3 - Homo sapiens (Human) - KHDC3L gene As part of the OOEP-KHDC3L scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Involved in the repair of DNA double strand breaks independent of its role in restarting stalled replication forks (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for maintenance of euploidy during cleavage-stage embryogenesis (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (By similarity). Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity). Capable of binding RNA (By similarity). Indicus|evm.model.CM009499.1.42 A0JNQ6 OOEP_BOVIN 100.000 0.985816 1.00714 OOEP - Oocyte-expressed protein homolog - Bos taurus (Bovine) - OOEP gene As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (By similarity). Thereby contributes to oocyte survival and the resumption and completion of meiosis (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Indicus|evm.model.CM009499.1.43 Q9NXZ2 DDX43_HUMAN 71.341 0.995342 0.993827 DDX43 - Probable ATP-dependent RNA helicase DDX43 - Homo sapiens (Human) - DDX43 gene RNA binding, RNA helicase activity Indicus|evm.model.CM009499.1.44 E1BGN7 CGAS_BOVIN 99.564 0.82821 1.11044 CGAS - Cyclic GMP-AMP synthase - Bos taurus (Bovine) - CGAS gene Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Preferentially binds long dsDNA (around 45 bp) and forms ladder-like networks that function cooperatively to stabilize individual cGAS-dsDNA complexes. Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm. Also acts as an innate immune sensor of infection by retroviruses by detecting the presence of reverse-transcribed DNA in the cytosol (By similarity). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (By similarity). Also detects the presence of DNA from bacteria (By similarity). cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells. cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner. In addition to antiviral activity, also involved in the response to cellular stresses, such as senescence, DNA damage or genome instability. Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via TMEM173/STING and promote cellular senescence. Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability. Micronuclei, which as frequently found in cancer cells, consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to cGAMP synthesis and subsequent activation of TMEM173/STING and type-I interferon production (By similarity). Acts as a suppressor of DNA repair in response to DNA damage: translocates to the nucleus following dephosphorylation at Tyr-204 and inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (By similarity). Indicus|evm.model.CM009499.1.45 Q4R4P6 MTO1_MACFA 89.017 0.997114 1.00145 MTO1 - Protein MTO1 homolog, mitochondrial precursor - Macaca fascicularis (Crab-eating macaque) - MTO1 gene Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Indicus|evm.model.CM009499.1.46 P68105 EF1A1_RABIT 100.000 0.99568 1.00216 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009499.1.47 Q9MZD1 S17A5_SHEEP 97.778 0.995968 1.00202 SLC17A5 - Sialin - Ovis aries (Sheep) - SLC17A5 gene Primary solute translocator for anionic substances; particularly it is a free sialic acid transporter in the lysosomes (Probable). Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties. Indicus|evm.model.CM009499.1.48 Q6YHK3 CD109_HUMAN 82.615 0.997921 0.998616 CD109 - CD109 antigen precursor - Homo sapiens (Human) - CD109 gene Modulates negatively TGFB1 signaling in keratinocytes. Indicus|evm.model.CM009499.1.50 Q9NRG4 SMYD2_HUMAN 56.944 0.919355 0.143187 SMYD2 - N-lysine methyltransferase SMYD2 - Homo sapiens (Human) - SMYD2 gene Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. Indicus|evm.model.CM009499.1.51 Q99715 COCA1_HUMAN 92.325 0.982014 0.998368 COL12A1 - Collagen alpha-1(XII) chain precursor - Homo sapiens (Human) - COL12A1 gene Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. Indicus|evm.model.CM009499.1.52 P13184 CX7A2_BOVIN 98.701 0.737864 1.24096 COX7A2 - Cytochrome c oxidase subunit 7A2, mitochondrial precursor - Bos taurus (Bovine) - COX7A2 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009499.1.53 Q17QL5 CC50A_BOVIN 90.932 0.994975 1.10249 TMEM30A - Cell cycle control protein 50A - Bos taurus (Bovine) - TMEM30A gene Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF). Can also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. Indicus|evm.model.CM009499.1.54 Q7Z7B0 FLIP1_HUMAN 94.889 0.998353 1.00082 FILIP1 - Filamin-A-interacting protein 1 - Homo sapiens (Human) - FILIP1 gene By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. Indicus|evm.model.CM009499.1.55 P18621 RL17_HUMAN 87.273 0.981818 0.298913 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009499.1.56 Q9GZR1 SENP6_HUMAN 81.810 0.998241 1.02248 SENP6 - Sentrin-specific protease 6 - Homo sapiens (Human) - SENP6 gene Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Indicus|evm.model.CM009499.1.57 E1BPK6 MYO6_BOVIN 99.846 0.998457 1.00077 MYO6 - Unconventional myosin-VI - Bos taurus (Bovine) - MYO6 gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (By similarity). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription (By similarity). Indicus|evm.model.CM009499.1.58 Q9GMS5 IMPG1_BOVIN 92.481 0.926316 0.358942 IMPG1 - Interphotoreceptor matrix proteoglycan 1 precursor - Bos taurus (Bovine) - IMPG1 gene Chondroitin sulfate-, heparin- and hyaluronan-binding protein (By similarity). May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (By similarity). Indicus|evm.model.CM009499.1.59 Q9GMS5 IMPG1_BOVIN 80.290 0.795396 0.492443 IMPG1 - Interphotoreceptor matrix proteoglycan 1 precursor - Bos taurus (Bovine) - IMPG1 gene Chondroitin sulfate-, heparin- and hyaluronan-binding protein (By similarity). May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (By similarity). Indicus|evm.model.CM009499.1.60 P62936 PPIA_PIG 55.414 0.861111 1.09756 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009499.1.61 P61928 RL37_RAT 97.938 0.979592 1.01031 Rpl37 - 60S ribosomal protein L37 - Rattus norvegicus (Rat) - Rpl37 gene Binds to the 23S rRNA. Indicus|evm.model.CM009499.1.63 P79250 5HT1B_CANLF 91.755 0.923267 1.03856 HTR1B - 5-hydroxytryptamine receptor 1B - Canis lupus familiaris (Dog) - HTR1B gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity). Indicus|evm.model.CM009499.1.64 A8MW99 MEI4_HUMAN 63.684 0.749004 0.651948 MEI4 - Meiosis-specific protein MEI4 - Homo sapiens (Human) - MEI4 gene Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Indicus|evm.model.CM009499.1.65 P23004 QCR2_BOVIN 99.117 0.995595 1.00221 UQCRC2 - Cytochrome b-c1 complex subunit 2, mitochondrial precursor - Bos taurus (Bovine) - UQCRC2 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (PubMed:9694818, PubMed:11073949). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Indicus|evm.model.CM009499.1.67 Q5VVH5 IKBP1_HUMAN 87.692 0.992337 1.00385 IRAK1BP1 - Interleukin-1 receptor-associated kinase 1-binding protein 1 - Homo sapiens (Human) - IRAK1BP1 gene Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity). Indicus|evm.model.CM009499.1.69 Q8WWQ0 PHIP_HUMAN 96.082 0.964384 1.0022 PHIP - PH-interacting protein - Homo sapiens (Human) - PHIP gene Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Indicus|evm.model.CM009499.1.70 Q3ZBV4 HMGN3_BOVIN 100.000 0.980198 1.01 HMGN3 - High mobility group nucleosome-binding domain-containing protein 3 - Bos taurus (Bovine) - HMGN3 gene Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). Indicus|evm.model.CM009499.1.71 Q86VQ0 LCA5_HUMAN 71.102 0.99708 0.982783 LCA5 - Lebercilin - Homo sapiens (Human) - LCA5 gene Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. Indicus|evm.model.CM009499.1.73 A4IFC4 SH3L2_BOVIN 97.872 0.641379 1.35514 SH3BGRL2 - SH3 domain-binding glutamic acid-rich-like protein 2 - Bos taurus (Bovine) - SH3BGRL2 gene Indicus|evm.model.CM009499.1.74 Q3S8M4 ELOV4_MACMU 92.038 0.993651 1.00318 ELOVL4 - Elongation of very long chain fatty acids protein 4 - Macaca mulatta (Rhesus macaque) - ELOVL4 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. Indicus|evm.model.CM009499.1.75 P33981 TTK_HUMAN 75.543 0.997599 0.971995 TTK - Dual specificity protein kinase TTK - Homo sapiens (Human) - TTK gene Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099). Indicus|evm.model.CM009499.1.76 P21839 ODBB_BOVIN 100.000 0.806723 0.303571 BCKDHB - 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor - Bos taurus (Bovine) - BCKDHB gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Indicus|evm.model.CM009499.1.77 P21839 ODBB_BOVIN 100.000 0.315271 0.517857 BCKDHB - 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor - Bos taurus (Bovine) - BCKDHB gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Indicus|evm.model.CM009499.1.79 Q96IP4 TET5A_HUMAN 95.249 0.995402 0.984163 TENT5A - Terminal nucleotidyltransferase 5A - Homo sapiens (Human) - TENT5A gene Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase. Indicus|evm.model.CM009499.1.82 Q9P2D0 IBTK_HUMAN 90.251 0.954802 1.04656 IBTK - Inhibitor of Bruton tyrosine kinase - Homo sapiens (Human) - IBTK gene Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. Indicus|evm.model.CM009499.1.85 Q13641 TPBG_HUMAN 86.429 0.995249 1.00238 TPBG - Trophoblast glycoprotein precursor - Homo sapiens (Human) - TPBG gene May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. Indicus|evm.model.CM009499.1.86 Q1JQA1 UBE3D_BOVIN 100.000 0.994872 1.00257 UBE3D - E3 ubiquitin-protein ligase E3D - Bos taurus (Bovine) - UBE3D gene E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Indicus|evm.model.CM009499.1.87 Q5JWR5 DOP1_HUMAN 94.487 0.999195 1.00852 DOP1A - Protein dopey-1 - Homo sapiens (Human) - DOP1A gene May be involved in protein traffic between late Golgi and early endosomes. Indicus|evm.model.CM009499.1.88 F1RQM2 AGM1_PIG 88.930 0.747238 1.33579 PGM3 - Phosphoacetylglucosamine mutase - Sus scrofa (Pig) - PGM3 gene Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. Indicus|evm.model.CM009499.1.89 Q9UIY3 RWD2A_HUMAN 95.548 0.993174 1.00342 RWDD2A - RWD domain-containing protein 2A - Homo sapiens (Human) - RWDD2A gene Indicus|evm.model.CM009499.1.90 Q29558 MAOX_PIG 93.175 0.988235 0.610413 ME1 - NADP-dependent malic enzyme - Sus scrofa (Pig) - ME1 gene cytosol, mitochondrion, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, manganese ion binding, malate metabolic process, pyruvate metabolic process, response to hormone Indicus|evm.model.CM009499.1.91 Q29558 MAOX_PIG 96.842 0.969072 0.174147 ME1 - NADP-dependent malic enzyme - Sus scrofa (Pig) - ME1 gene cytosol, mitochondrion, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, manganese ion binding, malate metabolic process, pyruvate metabolic process, response to hormone Indicus|evm.model.CM009499.1.92 Q5E9X7 PRS35_BOVIN 100.000 0.995157 1.00243 PRSS35 - Inactive serine protease 35 precursor - Bos taurus (Bovine) - PRSS35 gene Indicus|evm.model.CM009499.1.93 O60641 AP180_HUMAN 99.160 0.576547 0.676957 SNAP91 - Clathrin coat assembly protein AP180 - Homo sapiens (Human) - SNAP91 gene Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity). Indicus|evm.model.CM009499.1.94 Q6P5S2 LEG1H_HUMAN 62.264 0.918129 1.03636 LEG1 - Protein LEG1 homolog precursor - Homo sapiens (Human) - LEG1 gene May be involved in early liver development. Indicus|evm.model.CM009499.1.95 P38982 RSSA_CRIGR 69.540 0.987421 0.538983 Rpsa - 40S ribosomal protein SA - Cricetulus griseus (Chinese hamster) - Rpsa gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, Sindbis virus, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Indicus|evm.model.CM009499.1.96 Q5TF21 SOGA3_HUMAN 78.307 0.918367 0.413939 SOGA3 - Protein SOGA3 precursor - Homo sapiens (Human) - SOGA3 gene Indicus|evm.model.CM009499.1.97 Q5TF21 SOGA3_HUMAN 98.837 0.863179 0.524815 SOGA3 - Protein SOGA3 precursor - Homo sapiens (Human) - SOGA3 gene Indicus|evm.model.CM009499.1.98 Q6ZU52 K0408_HUMAN 71.758 0.997118 1 KIAA0408 - Uncharacterized protein KIAA0408 - Homo sapiens (Human) - KIAA0408 gene Indicus|evm.model.CM009499.1.99 Q2HJD5 ECHD1_BOVIN 99.667 0.993355 0.98366 ECHDC1 - Ethylmalonyl-CoA decarboxylase - Bos taurus (Bovine) - ECHDC1 gene Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level. Indicus|evm.model.CM009499.1.100 Q3T139 R146B_BOVIN 100.000 0.994236 1 RNF146B - E3 ubiquitin-protein ligase RNF146-B - Bos taurus (Bovine) - RNF146B gene E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity). Indicus|evm.model.CM009499.1.106 Q71SV0 LAP4B_BOVIN 90.769 0.977273 0.584071 LAPTM4B - Lysosomal-associated transmembrane protein 4B - Bos taurus (Bovine) - LAPTM4B gene Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. Indicus|evm.model.CM009499.1.107 A8E4M4 MCRI1_BOVIN 90.722 0.979592 1.01031 MCRIP1 - Mapk-regulated corepressor-interacting protein 1 - Bos taurus (Bovine) - MCRIP1 gene The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. Indicus|evm.model.CM009499.1.108 Q5EE01 CENPW_HUMAN 86.364 0.977528 1.01136 CENPW - Centromere protein W - Homo sapiens (Human) - CENPW gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. Indicus|evm.model.CM009499.1.109 Q05B63 TRM11_BOVIN 100.000 0.995662 1.00217 TRMT11 - tRNA (guanine(10)-N2)-methyltransferase homolog - Bos taurus (Bovine) - TRMT11 gene Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. Indicus|evm.model.CM009499.1.110 Q2YDJ4 HINT3_BOVIN 100.000 0.989071 1.00549 HINT3 - Histidine triad nucleotide-binding protein 3 - Bos taurus (Bovine) - HINT3 gene Hydrolyzes phosphoramidate and acyl-adenylate substrates. Indicus|evm.model.CM009499.1.111 Q8NI08 NCOA7_HUMAN 88.653 0.997872 0.997877 NCOA7 - Nuclear receptor coactivator 7 - Homo sapiens (Human) - NCOA7 gene Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. Indicus|evm.model.CM009499.1.112 Q9UBP5 HEY2_HUMAN 98.220 0.994083 1.00297 HEY2 - Hairy/enhancer-of-split related with YRPW motif protein 2 - Homo sapiens (Human) - HEY2 gene Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Indicus|evm.model.CM009499.1.113 Q13439 GOGA4_HUMAN 86.772 0.979167 0.0860987 GOLGA4 - Golgin subfamily A member 4 - Homo sapiens (Human) - GOLGA4 gene Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). Indicus|evm.model.CM009499.1.114 Q0P565 HDDC2_BOVIN 99.512 0.990291 1.00488 HDDC2 - 5'-deoxynucleotidase HDDC2 - Bos taurus (Bovine) - HDDC2 gene Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). Indicus|evm.model.CM009499.1.115 Q16890 TPD53_HUMAN 89.474 0.990476 1.02941 TPD52L1 - Tumor protein D53 - Homo sapiens (Human) - TPD52L1 gene cytoplasm, perinuclear region of cytoplasm, identical protein binding, protein homodimerization activity, G2/M transition of mitotic cell cycle, positive regulation of apoptotic signaling pathway, positive regulation of JNK cascade, positive regulation of MAP kinase activity Indicus|evm.model.CM009499.1.116 Q8TC41 RN217_HUMAN 92.111 0.983982 0.806273 RNF217 - Probable E3 ubiquitin-protein ligase RNF217 - Homo sapiens (Human) - RNF217 gene E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Indicus|evm.model.CM009499.1.119 Q4R5Y8 UB2G1_MACFA 48.148 0.157895 1.78824 UBE2G1 - Ubiquitin-conjugating enzyme E2 G1 - Macaca fascicularis (Crab-eating macaque) - UBE2G1 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. Indicus|evm.model.CM009499.1.120 P82179 TRDN_CANLF 84.314 0.124384 1.15835 TRDN - Triadin - Canis lupus familiaris (Dog) - TRDN gene Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. Indicus|evm.model.CM009499.1.122 Q95KF7 CLVS2_MACFA 99.694 0.993902 1.00306 CLVS2 - Clavesin-2 - Macaca fascicularis (Crab-eating macaque) - CLVS2 gene Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Indicus|evm.model.CM009499.1.124 Q3ZC91 ASM3A_BOVIN 99.778 0.995565 1.00222 SMPDL3A - Acid sphingomyelinase-like phosphodiesterase 3a precursor - Bos taurus (Bovine) - SMPDL3A gene Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity. Indicus|evm.model.CM009499.1.125 Q09139 FABP7_BOVIN 100.000 0.984962 1.00758 FABP7 - Fatty acid-binding protein, brain - Bos taurus (Bovine) - FABP7 gene FABP are thought to play a role in the intracellular transport of long chain fatty acids and their acyl-CoA esters. Binds oleic and palmitic acids but not palmitoyl CoA. Indicus|evm.model.CM009499.1.126 Q9C010 IPKB_HUMAN 73.611 0.972603 0.935897 PKIB - cAMP-dependent protein kinase inhibitor beta - Homo sapiens (Human) - PKIB gene Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Indicus|evm.model.CM009499.1.127 Q3MHV9 SERC1_BOVIN 97.487 0.994872 0.860927 SERINC1 - Serine incorporator 1 - Bos taurus (Bovine) - SERINC1 gene Enhances the incorporation of serine into phosphatidylserine and sphingolipids. Indicus|evm.model.CM009499.1.128 Q03933 HSF2_HUMAN 94.590 0.996132 0.964552 HSF2 - Heat shock factor protein 2 - Homo sapiens (Human) - HSF2 gene DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. Indicus|evm.model.CM009499.1.129 Q8HXB8 RL29_MACFA 76.786 0.964286 0.356688 RPL29 - 60S ribosomal protein L29 - Macaca fascicularis (Crab-eating macaque) - RPL29 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009499.1.130 P18246 CXA1_BOVIN 100.000 0.994792 1.00261 GJA1 - Gap junction alpha-1 protein - Bos taurus (Bovine) - GJA1 gene Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). Indicus|evm.model.CM009499.1.131 Q96NH3 BROMI_HUMAN 90.977 0.22534 0.935561 TBC1D32 - Protein broad-minded - Homo sapiens (Human) - TBC1D32 gene Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). Indicus|evm.model.CM009499.1.132 Q9H6P5 TASP1_HUMAN 75.000 0.967213 0.145238 TASP1 - Threonine aspartase 1 - Homo sapiens (Human) - TASP1 gene Protease responsible for KMT2A/MLL1 processing and activation (PubMed:14636557). It also activates KMT2D/MLL2 (By similarity). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (By similarity) (PubMed:14636557). Indicus|evm.model.CM009499.1.133 Q8N335 GPD1L_HUMAN 88.034 0.994318 1.00285 GPD1L - Glycerol-3-phosphate dehydrogenase 1-like protein - Homo sapiens (Human) - GPD1L gene Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. Indicus|evm.model.CM009499.1.134 O02773 MA1A1_PIG 92.145 0.996974 1.00303 MAN1A1 - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA - Sus scrofa (Pig) - MAN1A1 gene Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Indicus|evm.model.CM009499.1.135 Q8NB25 F184A_HUMAN 94.298 0.998247 1.00088 FAM184A - Protein FAM184A - Homo sapiens (Human) - FAM184A gene extracellular space Indicus|evm.model.CM009499.1.136 F1N2W9 MCM9_BOVIN 100.000 0.303951 0.86655 MCM9 - DNA helicase MCM9 - Bos taurus (Bovine) - MCM9 gene Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis. Indicus|evm.model.CM009499.1.137 Q5SZL2 CE85L_HUMAN 90.087 0.997522 1.00248 CEP85L - Centrosomal protein of 85 kDa-like - Homo sapiens (Human) - CEP85L gene Plays an essential role in neuronal cell migration. Indicus|evm.model.CM009499.1.138 P26882 PPID_BOVIN 73.451 0.978261 0.248649 PPID - Peptidyl-prolyl cis-trans isomerase D - Bos taurus (Bovine) - PPID gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Indicus|evm.model.CM009499.1.139 P26882 PPID_BOVIN 88.421 0.979167 0.259459 PPID - Peptidyl-prolyl cis-trans isomerase D - Bos taurus (Bovine) - PPID gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Indicus|evm.model.CM009499.1.140 Q5T1Q4 S35F1_HUMAN 95.724 0.980583 0.757353 SLC35F1 - Solute carrier family 35 member F1 - Homo sapiens (Human) - SLC35F1 gene Putative solute transporter. Indicus|evm.model.CM009499.1.143 Q96E22 NGBR_HUMAN 95.683 0.826347 0.569966 NUS1 - Dehydrodolichyl diphosphate synthase complex subunit NUS1 - Homo sapiens (Human) - NUS1 gene With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300). Indicus|evm.model.CM009499.1.144 Q9CQ76 NEPN_MOUSE 83.301 0.990253 1.00195 Nepn - Nephrocan precursor - Mus musculus (Mouse) - Nepn gene May inhibit TGF-beta signaling. Indicus|evm.model.CM009499.1.145 Q9HD26 GOPC_HUMAN 96.404 0.956897 1.00433 GOPC - Golgi-associated PDZ and coiled-coil motif-containing protein - Homo sapiens (Human) - GOPC gene Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. Indicus|evm.model.CM009499.1.146 Q8N8Z6 DCBD1_HUMAN 81.938 0.983871 0.953846 DCBLD1 - Discoidin, CUB and LCCL domain-containing protein 1 precursor - Homo sapiens (Human) - DCBLD1 gene Indicus|evm.model.CM009499.1.147 P08922 ROS1_HUMAN 83.510 0.999147 0.999148 ROS1 - Proto-oncogene tyrosine-protein kinase ROS precursor - Homo sapiens (Human) - ROS1 gene Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. Indicus|evm.model.CM009499.1.148 Q8N8G2 VGLL2_HUMAN 94.643 0.701258 1.00315 VGLL2 - Transcription cofactor vestigial-like protein 2 - Homo sapiens (Human) - VGLL2 gene May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles. Indicus|evm.model.CM009499.1.149 D2HNW6 RFX6_AILME 93.103 0.997845 1 RFX6 - DNA-binding protein RFX6 - Ailuropoda melanoleuca (Giant panda) - RFX6 gene Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription. Indicus|evm.model.CM009499.1.150 E1BPQ3 GPC6A_BOVIN 79.812 0.968085 0.211712 GPRC6A - G-protein coupled receptor family C group 6 member A precursor - Bos taurus (Bovine) - GPRC6A gene Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (By similarity). Indicus|evm.model.CM009499.1.151 E1BPQ3 GPC6A_BOVIN 87.444 0.99095 0.248874 GPRC6A - G-protein coupled receptor family C group 6 member A precursor - Bos taurus (Bovine) - GPRC6A gene Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (By similarity). Indicus|evm.model.CM009499.1.152 A6QPI4 F162B_BOVIN 100.000 0.987805 1.00613 FAM162B - Protein FAM162B - Bos taurus (Bovine) - FAM162B gene Indicus|evm.model.CM009499.1.153 O15131 IMA6_HUMAN 98.134 0.990741 1.00746 KPNA5 - Importin subunit alpha-6 - Homo sapiens (Human) - KPNA5 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Indicus|evm.model.CM009499.1.154 Q3SWY8 ZUP1_BOVIN 99.827 0.996552 1.00173 ZUP1 - Zinc finger-containing ubiquitin peptidase 1 - Bos taurus (Bovine) - ZUP1 gene Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress. Indicus|evm.model.CM009499.1.155 Q5TD94 RSH4A_HUMAN 78.835 0.968188 1.00978 RSPH4A - Radial spoke head protein 4 homolog A - Homo sapiens (Human) - RSPH4A gene Component of the axonemal radial spoke head which plays an important role in ciliary motility (PubMed:19200523). Essential for triplet radial spokes (RS1, RS2 and RS3) head assembly in the motile cilia (By similarity). Indicus|evm.model.CM009499.1.156 Q5E975 TM230_BOVIN 51.515 0.984962 1.10833 TMEM230 - Transmembrane protein 230 - Bos taurus (Bovine) - TMEM230 gene Involved in trafficking and recycling of synaptic vesicles. Indicus|evm.model.CM009499.1.157 O46640 ST3A1_RABIT 65.686 0.907121 1.07309 SULT3A1 - Amine sulfotransferase - Oryctolagus cuniculus (Rabbit) - SULT3A1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the N-sulfonation of amines (PTHP, aniline, 4-chloroaniline, 2-naphthylamine). Indicus|evm.model.CM009499.1.158 Q9H446 RWDD1_HUMAN 96.708 0.991803 1.00412 RWDD1 - RWD domain-containing protein 1 - Homo sapiens (Human) - RWDD1 gene Protects DRG2 from proteolytic degradation. Indicus|evm.model.CM009499.1.159 Q5JW98 CAHM4_HUMAN 80.892 0.987382 1.00955 CALHM4 - Calcium homeostasis modulator protein 4 - Homo sapiens (Human) - CALHM4 gene Pore-forming subunit of a voltage-gated ion channel. Indicus|evm.model.CM009499.1.160 Q5T215 TPC3L_HUMAN 94.059 0.862069 0.640884 TRAPPC3L - Trafficking protein particle complex subunit 3-like protein - Homo sapiens (Human) - TRAPPC3L gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Indicus|evm.model.CM009499.1.161 Q5R3K3 CAHM6_HUMAN 76.489 0.993691 1.00635 CALHM6 - Calcium homeostasis modulator protein 6 - Homo sapiens (Human) - CALHM6 gene Pore-forming subunit of a voltage-gated ion channel. Indicus|evm.model.CM009499.1.162 P0C2H4 DSE_BOVIN 99.791 0.997917 1.00209 DSE - Dermatan-sulfate epimerase precursor - Bos taurus (Bovine) - DSE gene Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate. Indicus|evm.model.CM009499.1.163 Q0P5N2 TSYL1_BOVIN 99.769 0.995381 1.00231 TSPYL1 - Testis-specific Y-encoded-like protein 1 - Bos taurus (Bovine) - TSPYL1 gene chromatin, nucleus, chromatin binding, histone binding Indicus|evm.model.CM009499.1.164 Q9UJ04 TSYL4_HUMAN 81.490 0.995181 1.00242 TSPYL4 - Testis-specific Y-encoded-like protein 4 - Homo sapiens (Human) - TSPYL4 gene chromatin, nucleus, chromatin binding, histone binding Indicus|evm.model.CM009499.1.165 Q2TBU5 NT5D1_BOVIN 100.000 0.995585 1.00221 NT5DC1 - 5'-nucleotidase domain-containing protein 1 - Bos taurus (Bovine) - NT5DC1 gene 5'-nucleotidase activity Indicus|evm.model.CM009499.1.166 Q922K9 FRK_MOUSE 88.716 0.996117 1.00586 Frk - Tyrosine-protein kinase FRK - Mus musculus (Mouse) - Frk gene Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity). Indicus|evm.model.CM009499.1.168 Q8BSL4 HS3S5_MOUSE 97.143 0.747312 1.07514 Hs3st5 - Heparan sulfate glucosamine 3-O-sulfotransferase 5 - Mus musculus (Mouse) - Hs3st5 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2 (By similarity). Indicus|evm.model.CM009499.1.169 Q92769 HDAC2_HUMAN 91.803 0.995595 0.930328 HDAC2 - Histone deacetylase 2 - Homo sapiens (Human) - HDAC2 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. Indicus|evm.model.CM009499.1.172 Q0D252 F229B_BOVIN 100.000 0.975309 1.0125 FAM229B - Protein FAM229B - Bos taurus (Bovine) - FAM229B gene Indicus|evm.model.CM009499.1.173 Q9UJT0 TBE_HUMAN 94.105 0.846429 1.17895 TUBE1 - Tubulin epsilon chain - Homo sapiens (Human) - TUBE1 gene cytoplasm, microtubule, pericentriolar material, GTP binding, structural constituent of cytoskeleton, centrosome cycle, microtubule cytoskeleton organization, mitotic cell cycle Indicus|evm.model.CM009499.1.174 O95389 CCN6_HUMAN 83.333 0.994366 1.00282 CCN6 - Cellular communication network factor 6 precursor - Homo sapiens (Human) - CCN6 gene Plays a role in mitochondrial electron transport and mitochondrial respiration (PubMed:27252383). Through its regulation of the mitochondrial function may play a role in normal postnatal skeletal growth and cartilage homeostasis (PubMed:27252383, PubMed:10471507). Indicus|evm.model.CM009499.1.176 A0JNB0 FYN_BOVIN 100.000 0.996283 1.00186 FYN - Tyrosine-protein kinase Fyn - Bos taurus (Bovine) - FYN gene Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Indicus|evm.model.CM009499.1.177 O43734 CIKS_HUMAN 82.923 0.986038 0.998258 TRAF3IP2 - E3 ubiquitin ligase TRAF3IP2 - Homo sapiens (Human) - TRAF3IP2 gene E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). Indicus|evm.model.CM009499.1.180 O60673 REV3L_HUMAN 94.068 0.0742496 1.01118 REV3L - DNA polymerase zeta catalytic subunit - Homo sapiens (Human) - REV3L gene Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. Indicus|evm.model.CM009499.1.181 Q5TF39 MFS4B_HUMAN 84.854 0.901754 1.10039 MFSD4B - Sodium-dependent glucose transporter 1 - Homo sapiens (Human) - MFSD4B gene May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney. Indicus|evm.model.CM009499.1.182 Q8TF71 MOT10_HUMAN 88.247 0.996124 1.00194 SLC16A10 - Monocarboxylate transporter 10 - Homo sapiens (Human) - SLC16A10 gene Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity). Indicus|evm.model.CM009499.1.183 Q2YDN6 RPF2_BOVIN 99.673 0.993485 1.00327 RPF2 - Ribosome production factor 2 homolog - Bos taurus (Bovine) - RPF2 gene Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. Indicus|evm.model.CM009499.1.184 Q969F1 TF3C6_HUMAN 85.870 0.75 1.14554 GTF3C6 - General transcription factor 3C polypeptide 6 - Homo sapiens (Human) - GTF3C6 gene Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. Indicus|evm.model.CM009499.1.185 P50243 DCAM_BOVIN 100.000 0.99403 1.00299 AMD1 - S-adenosylmethionine decarboxylase proenzyme precursor - Bos taurus (Bovine) - AMD1 gene Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. Indicus|evm.model.CM009499.1.186 Q9BWU1 CDK19_HUMAN 98.207 0.996008 0.998008 CDK19 - Cyclin-dependent kinase 19 - Homo sapiens (Human) - CDK19 gene cytosol, mediator complex, nucleus, cyclin-dependent protein serine/threonine kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, protein phosphorylation Indicus|evm.model.CM009499.1.187 Q17QN9 S22AG_BOVIN 99.650 0.99651 1.00175 SLC22A16 - Solute carrier family 22 member 16 - Bos taurus (Bovine) - SLC22A16 gene High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent (By similarity). Indicus|evm.model.CM009499.1.188 P31228 OXDD_BOVIN 99.707 0.994152 1.00293 DDO - D-aspartate oxidase - Bos taurus (Bovine) - DDO gene Indicus|evm.model.CM009499.1.189 Q5JXM2 MET24_HUMAN 90.661 0.924188 0.756831 METTL24 - Methyltransferase-like protein 24 precursor - Homo sapiens (Human) - METTL24 gene Indicus|evm.model.CM009499.1.190 O60508 PRP17_HUMAN 98.446 0.898911 1.11054 CDC40 - Pre-mRNA-processing factor 17 - Homo sapiens (Human) - CDC40 gene Required for pre-mRNA splicing as component of the activated spliceosome. Indicus|evm.model.CM009499.1.191 Q0IIJ3 WASF1_BOVIN 100.000 0.996429 1.00179 WASF1 - Wiskott-Aldrich syndrome protein family member 1 - Bos taurus (Bovine) - WASF1 gene Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (By similarity). Indicus|evm.model.CM009499.1.192 P46095 GPR6_HUMAN 92.877 0.994536 1.01105 GPR6 - G-protein coupled receptor 6 - Homo sapiens (Human) - GPR6 gene Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Indicus|evm.model.CM009499.1.193 Q92562 FIG4_HUMAN 95.039 0.997755 0.982359 FIG4 - Polyphosphoinositide phosphatase - Homo sapiens (Human) - FIG4 gene The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. Indicus|evm.model.CM009499.1.194 O43167 ZBT24_HUMAN 93.848 0.261637 3.82209 ZBTB24 - Zinc finger and BTB domain-containing protein 24 - Homo sapiens (Human) - ZBTB24 gene May be involved in BMP2-induced transcription. Indicus|evm.model.CM009499.1.195 F1MH07 MICA1_BOVIN 99.813 0.936077 1.06729 MICAL1 - [F-actin]-monooxygenase MICAL1 - Bos taurus (Bovine) - MICAL1 gene Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. Indicus|evm.model.CM009499.1.196 O60906 NSMA_HUMAN 84.870 0.995283 1.00236 SMPD2 - Sphingomyelin phosphodiesterase 2 - Homo sapiens (Human) - SMPD2 gene Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). Indicus|evm.model.CM009499.1.197 Q1RMP7 PPIL6_BOVIN 100.000 0.993506 1.00326 PPIL6 - Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 - Bos taurus (Bovine) - PPIL6 gene Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. Indicus|evm.model.CM009499.1.198 Q2YDH0 MUC24_BOVIN 100.000 0.98995 1.00505 CD164 - Sialomucin core protein 24 precursor - Bos taurus (Bovine) - CD164 gene Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity). Indicus|evm.model.CM009499.1.199 Q0VG85 CC162_MOUSE 73.708 0.400832 2.37171 Ccdc162 - Coiled-coil domain-containing protein 162 - Mus musculus (Mouse) - Ccdc162 gene Indicus|evm.model.CM009499.1.200 Q8IYX8 CE57L_HUMAN 80.713 0.995807 1.03696 CEP57L1 - Centrosomal protein CEP57L1 - Homo sapiens (Human) - CEP57L1 gene Centrosomal protein which may be required for microtubule attachment to centrosomes. Indicus|evm.model.CM009499.1.201 P58006 SESN1_MOUSE 98.257 0.82971 1.12195 Sesn1 - Sestrin-1 - Mus musculus (Mouse) - Sesn1 gene Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25259925). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed (By similarity). Indicus|evm.model.CM009499.1.202 P0C6R2 ARMC2_BOVIN 87.659 0.997537 0.938728 ARMC2 - Armadillo repeat-containing protein 2 - Bos taurus (Bovine) - ARMC2 gene Required for sperm flagellum axoneme organization and function. Involved in axonemal central pair complex assembly and/or stability. Indicus|evm.model.CM009499.1.203 O43524 FOXO3_HUMAN 95.542 0.997028 1 FOXO3 - Forkhead box protein O3 - Homo sapiens (Human) - FOXO3 gene Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Indicus|evm.model.CM009499.1.205 Q8WV93 AFG1L_HUMAN 92.931 0.995842 1 AFG1L - AFG1-like ATPase - Homo sapiens (Human) - AFG1L gene Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain (PubMed:26759378, PubMed:27323408). Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress (PubMed:27323408). Indicus|evm.model.CM009499.1.206 P79103 RS4_BOVIN 99.240 0.992424 1.0038 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009499.1.207 Q5U211 SNX3_RAT 100.000 0.98773 1.00617 Snx3 - Sorting nexin-3 - Rattus norvegicus (Rat) - Snx3 gene Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. Involved in regulation of neurite outgrowth in primary neurons. Indicus|evm.model.CM009499.1.208 Q9Y466 NR2E1_HUMAN 99.468 0.848416 1.14805 NR2E1 - Nuclear receptor subfamily 2 group E member 1 - Homo sapiens (Human) - NR2E1 gene Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells. Indicus|evm.model.CM009499.1.209 Q5E9F5 TAGL2_BOVIN 89.447 0.99 1.00503 TAGLN2 - Transgelin-2 - Bos taurus (Bovine) - TAGLN2 gene Indicus|evm.model.CM009499.1.210 Q86WC4 OSTM1_HUMAN 90.301 0.886567 1.00299 OSTM1 - Osteopetrosis-associated transmembrane protein 1 precursor - Homo sapiens (Human) - OSTM1 gene Required for osteoclast and melanocyte maturation and function. Indicus|evm.model.CM009499.1.211 Q9UGP8 SEC63_HUMAN 98.421 0.997372 1.00132 SEC63 - Translocation protein SEC63 homolog - Homo sapiens (Human) - SEC63 gene Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). Indicus|evm.model.CM009499.1.212 Q8N228 SCML4_HUMAN 96.454 0.426829 0.792271 SCML4 - Sex comb on midleg-like protein 4 - Homo sapiens (Human) - SCML4 gene Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). Indicus|evm.model.CM009499.1.214 A7XYH9 SOBP_BOVIN 100.000 0.161157 0.832569 SOBP - Sine oculis-binding protein homolog - Bos taurus (Bovine) - SOBP gene Implicated in development of the cochlea. Indicus|evm.model.CM009499.1.215 Q86YH6 DLP1_HUMAN 88.793 0.982609 0.576441 PDSS2 - All trans-polyprenyl-diphosphate synthase PDSS2 - Homo sapiens (Human) - PDSS2 gene Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699). Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9) and ubiquinone-10 (Q10) respectively (PubMed:16262699). The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699). May play a role during cerebellar development (By similarity). May regulate mitochondrial respiratory chain function (By similarity). Indicus|evm.model.CM009499.1.216 Q5T5X7 BEND3_HUMAN 93.848 0.99759 1.00242 BEND3 - BEN domain-containing protein 3 - Homo sapiens (Human) - BEND3 gene Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). Indicus|evm.model.CM009499.1.217 Q9P0P8 MRES1_HUMAN 80.083 0.991632 0.995833 MTRES1 - Mitochondrial transcription rescue factor 1 precursor - Homo sapiens (Human) - MTRES1 gene Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability (PubMed:31226201). Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:33243891, PubMed:31396629). As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891). Indicus|evm.model.CM009499.1.218 O88428 PAPS2_MOUSE 81.081 0.285714 0.202899 Papss2 - Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 - Mus musculus (Mouse) - Papss2 gene Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have an important role in skeletogenesis during postnatal growth. Indicus|evm.model.CM009499.1.219 P25063 CD24_HUMAN 75.949 0.961538 0.975 CD24 - Signal transducer CD24 precursor - Homo sapiens (Human) - CD24 gene May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). Indicus|evm.model.CM009499.1.220 P62752 RL23A_RAT 90.000 0.971429 0.448718 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009499.1.221 Q29RP9 GATA_BOVIN 99.810 0.996205 1.0019 QRSL1 - Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial - Bos taurus (Bovine) - QRSL1 gene Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Indicus|evm.model.CM009499.1.222 Q0VC50 RT4I1_BOVIN 100.000 0.994962 1.00253 RTN4IP1 - Reticulon-4-interacting protein 1, mitochondrial precursor - Bos taurus (Bovine) - RTN4IP1 gene Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury. Indicus|evm.model.CM009499.1.223 Q9Y4K1 CRBG1_HUMAN 79.700 0.807456 1.22983 CRYBG1 - Beta/gamma crystallin domain-containing protein 1 - Homo sapiens (Human) - CRYBG1 gene May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. Indicus|evm.model.CM009499.1.224 Q3MQ24 ATG5_BOVIN 100.000 0.918605 0.625455 ATG5 - Autophagy protein 5 - Bos taurus (Bovine) - ATG5 gene Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. Indicus|evm.model.CM009499.1.226 O75626 PRDM1_HUMAN 86.007 0.997549 0.989091 PRDM1 - PR domain zinc finger protein 1 - Homo sapiens (Human) - PRDM1 gene Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Indicus|evm.model.CM009499.1.228 Q6Q311 RS25_SHEEP 92.593 0.879121 0.728 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Indicus|evm.model.CM009499.1.229 Q9XTA2 PPCE_BOVIN 98.851 0.94046 1.04085 PREP - Prolyl endopeptidase - Bos taurus (Bovine) - PREP gene Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Indicus|evm.model.CM009499.1.230 Q8VH49 HIG1A_RAT 83.871 0.978723 1.01075 Higd1a - HIG1 domain family member 1A, mitochondrial - Rattus norvegicus (Rat) - Higd1a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Indicus|evm.model.CM009499.1.231 Q9HBV1 POPD3_HUMAN 92.440 0.993151 1.00344 POPDC3 - Popeye domain-containing protein 3 - Homo sapiens (Human) - POPDC3 gene May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding. May play a role in the regulation of KCNK2/TREK-1-mediated current amplitude (PubMed:31610034). Indicus|evm.model.CM009499.1.232 B8Q0B2 POPD1_PIG 90.845 0.700495 1.12222 BVES - Blood vessel epicardial substance - Sus scrofa (Pig) - BVES gene Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Important for skeletal muscle and heart development. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury (By similarity). Indicus|evm.model.CM009499.1.233 Q6ZN17 LN28B_HUMAN 90.625 0.59434 0.424 LIN28B - Protein lin-28 homolog B - Homo sapiens (Human) - LIN28B gene Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. Indicus|evm.model.CM009499.1.234 F1N6G5 HACE1_BOVIN 99.890 0.997802 1.0011 HACE1 - E3 ubiquitin-protein ligase HACE1 - Bos taurus (Bovine) - HACE1 gene E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. Indicus|evm.model.CM009499.1.236 P68105 EF1A1_RABIT 93.182 0.993528 0.668831 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009499.1.239 A0A0B4J1U6 TVB9_HUMAN 65.263 0.717557 1.14912 TRBV9 - T cell receptor beta variable 9 precursor - Homo sapiens (Human) - TRBV9 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009499.1.241 Q8NCR0 B3GL2_HUMAN 88.626 0.985915 0.426 B3GALNT2 - UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 - Homo sapiens (Human) - B3GALNT2 gene Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Indicus|evm.model.CM009499.1.243 E1BNG3 ASCC3_BOVIN 99.927 0.664572 0.940027 ascc3 - Activating signal cointegrator 1 complex subunit 3 - Bos taurus (Bovine) - ascc3 gene 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Indicus|evm.model.CM009499.1.244 P81133 SIM1_HUMAN 100.000 0.393939 0.818538 SIM1 - Single-minded homolog 1 - Homo sapiens (Human) - SIM1 gene Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. Indicus|evm.model.CM009499.1.245 P62309 RUXG_MOUSE 92.105 0.974026 1.01316 Snrpg - Small nuclear ribonucleoprotein G - Mus musculus (Mouse) - Snrpg gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. Indicus|evm.model.CM009499.1.246 P62944 AP2B1_RAT 90.854 0.253521 0.681964 Ap2b1 - AP-2 complex subunit beta - Rattus norvegicus (Rat) - Ap2b1 gene Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly (By similarity). Indicus|evm.model.CM009499.1.247 P63009 AP2B1_BOVIN 86.713 0.986014 0.152615 AP2B1 - AP-2 complex subunit beta - Bos taurus (Bovine) - AP2B1 gene Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly (By similarity). Indicus|evm.model.CM009499.1.248 Q969V1 MCHR2_HUMAN 71.090 0.7897 0.685294 MCHR2 - Melanin-concentrating hormone receptor 2 - Homo sapiens (Human) - MCHR2 gene Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis. Indicus|evm.model.CM009499.1.249 Q9H4Q3 PRD13_HUMAN 90.268 0.997175 1.00141 PRDM13 - PR domain zinc finger protein 13 - Homo sapiens (Human) - PRDM13 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009499.1.250 Q3ZCK5 CCNC_BOVIN 100.000 0.992958 1.00353 CCNC - Cyclin-C - Bos taurus (Bovine) - CCNC gene Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity). Indicus|evm.model.CM009499.1.251 H0UI37 TSTD3_HUMAN 77.011 0.5375 1.64948 TSTD3 - Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3 - Homo sapiens (Human) - TSTD3 gene Indicus|evm.model.CM009499.1.252 Q70EL2 UBP45_HUMAN 81.685 0.997555 1.00491 USP45 - Ubiquitin carboxyl-terminal hydrolase 45 - Homo sapiens (Human) - USP45 gene Catalyzes the deubiquitination of SPDL1 (PubMed:30258100). Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (PubMed:25538220). May be involved in the maintenance of photoreceptor function (PubMed:30573563). May play a role in normal retinal development (By similarity). Plays a role in cell migration (PubMed:30258100). Indicus|evm.model.CM009499.1.254 Q8TF01 PNISR_HUMAN 97.764 0.986503 1.01242 PNISR - Arginine/serine-rich protein PNISR - Homo sapiens (Human) - PNISR gene cytosol, nuclear speck, nucleoplasm, plasma membrane, presynaptic active zone, RNA binding Indicus|evm.model.CM009499.1.255 Q3T131 COQ3_BOVIN 99.730 0.994609 1.0027 COQ3 - Ubiquinone biosynthesis O-methyltransferase, mitochondrial precursor - Bos taurus (Bovine) - COQ3 gene O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. Indicus|evm.model.CM009499.1.256 Q5TGI0 FAXC_HUMAN 99.123 0.518265 1.0709 FAXC - Failed axon connections homolog - Homo sapiens (Human) - FAXC gene May play a role in axonal development. Indicus|evm.model.CM009499.1.257 Q0VD31 FBXL4_BOVIN 100.000 0.979866 0.719807 FBXL4 - F-box/LRR-repeat protein 4 - Bos taurus (Bovine) - FBXL4 gene mitochondrial intermembrane space Indicus|evm.model.CM009499.1.258 Q0VD31 FBXL4_BOVIN 100.000 0.768657 0.215781 FBXL4 - F-box/LRR-repeat protein 4 - Bos taurus (Bovine) - FBXL4 gene mitochondrial intermembrane space Indicus|evm.model.CM009499.1.259 P20265 PO3F2_HUMAN 100.000 0.827004 0.534989 POU3F2 - POU domain, class 3, transcription factor 2 - Homo sapiens (Human) - POU3F2 gene Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). Indicus|evm.model.CM009499.1.260 P20265 PO3F2_HUMAN 98.485 0.52 0.282167 POU3F2 - POU domain, class 3, transcription factor 2 - Homo sapiens (Human) - POU3F2 gene Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). Indicus|evm.model.CM009499.1.261 P24049 RL17_RAT 93.478 0.989189 1.00543 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009499.1.262 Q9Y2H2 SAC2_HUMAN 64.119 0.811623 0.440813 INPP5F - Phosphatidylinositide phosphatase SAC2 - Homo sapiens (Human) - INPP5F gene Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). Indicus|evm.model.CM009499.1.263 E1BGH8 MMS22_BOVIN 99.676 0.605315 0.81672 MMS22L - Protein MMS22-like - Bos taurus (Bovine) - MMS22L gene Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA (By similarity). Indicus|evm.model.CM009499.1.264 Q96NJ5 KLH32_HUMAN 98.226 0.996779 1.00161 KLHL32 - Kelch-like protein 32 - Homo sapiens (Human) - KLHL32 gene Indicus|evm.model.CM009499.1.265 A4FUH5 NDUF4_BOVIN 100.000 0.988636 1.00571 NDUFAF4 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 - Bos taurus (Bovine) - NDUFAF4 gene Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion (By similarity). Indicus|evm.model.CM009499.1.266 Q9BZJ6 GPR63_HUMAN 94.033 0.995238 1.00239 GPR63 - Probable G-protein coupled receptor 63 - Homo sapiens (Human) - GPR63 gene Orphan receptor. May play a role in brain function. Indicus|evm.model.CM009499.1.267 Q2YDK0 FHL5_BOVIN 100.000 0.992982 1.00352 FHL5 - Four and a half LIM domains protein 5 - Bos taurus (Bovine) - FHL5 gene May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity). Indicus|evm.model.CM009499.1.268 A1A4I9 UFL1_BOVIN 96.843 0.997399 0.97096 UFL1 - E3 UFM1-protein ligase 1 - Bos taurus (Bovine) - UFL1 gene E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity). In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane by DDRGK1, and mediates ufmylation of proteins such as RPN1 and RPL26/uL24, thereby promoting reticulophagy of endoplasmic reticulum sheets (By similarity). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) via ERN1/IRE1-alpha (By similarity). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:30881595). Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor (PubMed:31721015, PubMed:31078114, PubMed:30881595, PubMed:32050508). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is a collateral effect or is required for ufmylation (By similarity). Catalyzes ufmylation of various subunits of the ribosomal complex or associated components, such as RPS3/uS3, RPS20/uS10, RPL10/uL16, RPL26/uL24 and EIF6 (By similarity). Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (By similarity). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 (By similarity). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (By similarity). Required for hematopoietic stem cell function and hematopoiesis. Required for cardiac homeostasis (By similarity). Indicus|evm.model.CM009499.1.269 Q8HZR2 FUT9_BOVIN 99.721 0.994444 1.00279 FUT9 - 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 - Bos taurus (Bovine) - FUT9 gene Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth. Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis. Furthermore, it is capable to synthesizes Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis. Indicus|evm.model.CM009499.1.271 Q5RD93 MANEA_PONAB 84.061 0.811388 1.21645 MANEA - Glycoprotein endo-alpha-1,2-mannosidase - Pongo abelii (Sumatran orangutan) - MANEA gene Indicus|evm.model.CM009499.1.273 Q5R573 RBL2A_PONAB 59.729 0.976048 0.729258 RABL2A - Rab-like protein 2A - Pongo abelii (Sumatran orangutan) - RABL2A gene Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail. Indicus|evm.model.CM009499.1.274 Q1ACD8 TRIM5_PANPA 51.662 0.989556 0.776876 TRIM5 - Tripartite motif-containing protein 5 - Pan paniscus (Pygmy chimpanzee) - TRIM5 gene Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Indicus|evm.model.CM009499.1.275 Q15375 EPHA7_HUMAN 99.299 0.997998 1.001 EPHA7 - Ephrin type-A receptor 7 precursor - Homo sapiens (Human) - EPHA7 gene Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Indicus|evm.model.CM009499.1.276 Q58D08 P5CR3_BOVIN 73.077 0.344595 0.480519 PYCR3 - Pyrroline-5-carboxylate reductase 3 - Bos taurus (Bovine) - PYCR3 gene Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. Indicus|evm.model.CM009499.1.278 Q3T0Q8 UT14A_BOVIN 88.506 0.955947 0.58961 UTP14A - U3 small nucleolar RNA-associated protein 14 homolog A - Bos taurus (Bovine) - UTP14A gene May be required for ribosome biogenesis. Indicus|evm.model.CM009499.1.279 Q3T0Q8 UT14A_BOVIN 79.795 0.988281 0.332468 UTP14A - U3 small nucleolar RNA-associated protein 14 homolog A - Bos taurus (Bovine) - UTP14A gene May be required for ribosome biogenesis. Indicus|evm.model.CM009499.1.280 O43318 M3K7_HUMAN 99.175 0.996705 1.00165 MAP3K7 - Mitogen-activated protein kinase kinase kinase 7 - Homo sapiens (Human) - MAP3K7 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Indicus|evm.model.CM009499.1.282 Q9BYV9 BACH2_HUMAN 93.713 0.966705 1.03567 BACH2 - Transcription regulator protein BACH2 - Homo sapiens (Human) - BACH2 gene Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). Indicus|evm.model.CM009499.1.283 Q969M2 CXA10_HUMAN 81.681 0.980932 0.869245 GJA10 - Gap junction alpha-10 protein - Homo sapiens (Human) - GJA10 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity). Indicus|evm.model.CM009499.1.284 Q9UKL3 C8AP2_HUMAN 76.823 0.998987 0.995964 CASP8AP2 - CASP8-associated protein 2 - Homo sapiens (Human) - CASP8AP2 gene Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. Indicus|evm.model.CM009499.1.285 Q9NU22 MDN1_HUMAN 87.279 0.999462 0.996962 MDN1 - Midasin - Homo sapiens (Human) - MDN1 gene Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). Indicus|evm.model.CM009499.1.286 Q32LM5 LYRM2_BOVIN 98.864 0.977528 1.01136 LYRM2 - LYR motif-containing protein 2 - Bos taurus (Bovine) - LYRM2 gene Indicus|evm.model.CM009499.1.287 Q9Y2G4 ANKR6_HUMAN 91.495 0.99726 1.00413 ANKRD6 - Ankyrin repeat domain-containing protein 6 - Homo sapiens (Human) - ANKRD6 gene Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. Indicus|evm.model.CM009499.1.289 Q9NQL2 RRAGD_HUMAN 97.500 0.994975 0.995 RRAGD - Ras-related GTP-binding protein D - Homo sapiens (Human) - RRAGD gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279). Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form (PubMed:24095279). In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279). This is a crucial step in the activation of the TOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279). Indicus|evm.model.CM009499.1.290 Q9Y385 UB2J1_HUMAN 95.597 0.99373 1.00314 UBE2J1 - Ubiquitin-conjugating enzyme E2 J1 - Homo sapiens (Human) - UBE2J1 gene Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Indicus|evm.model.CM009499.1.291 P50572 GBRR1_RAT 86.168 0.904762 1.00625 Gabrr1 - Gamma-aminobutyric acid receptor subunit rho-1 precursor - Rattus norvegicus (Rat) - Gabrr1 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. Indicus|evm.model.CM009499.1.292 Q8IYS1 P20D2_HUMAN 88.167 0.995338 0.983945 PM20D2 - Peptidase M20 domain-containing protein 2 - Homo sapiens (Human) - PM20D2 gene nucleoplasm, dipeptidase activity, identical protein binding, proteolysis, regulation of cellular protein metabolic process Indicus|evm.model.CM009499.1.293 Q8WXF0 SRS12_HUMAN 97.590 0.988024 0.639847 SRSF12 - Serine/arginine-rich splicing factor 12 - Homo sapiens (Human) - SRSF12 gene Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation. Indicus|evm.model.CM009499.1.294 Q12796 PNRC1_HUMAN 87.842 0.993939 1.00917 PNRC1 - Proline-rich nuclear receptor coactivator 1 - Homo sapiens (Human) - PNRC1 gene Nuclear receptor coactivator. May play a role in signal transduction. Indicus|evm.model.CM009499.1.296 O60942 MCE1_HUMAN 98.406 0.998008 0.840871 RNGTT - mRNA-capping enzyme - Homo sapiens (Human) - RNGTT gene Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. Indicus|evm.model.CM009499.1.297 Q5IS73 CNR1_PANTR 97.458 0.995772 1.00212 CNR1 - Cannabinoid receptor 1 - Pan troglodytes (Chimpanzee) - CNR1 gene G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (By similarity). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes. In the liver, activation by cannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism. In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism. In response to cannabinoid anandamide, elicits a proinflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). Indicus|evm.model.CM009499.1.298 Q2YDG7 SACA1_BOVIN 92.977 0.993333 1.07527 SPACA1 - Sperm acrosome membrane-associated protein 1 precursor - Bos taurus (Bovine) - SPACA1 gene Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. Indicus|evm.model.CM009499.1.299 A8YXY8 AKIR2_BOVIN 76.355 0.987179 0.768473 AKIRIN2 - Akirin-2 - Bos taurus (Bovine) - AKIRIN2 gene Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). Indicus|evm.model.CM009499.1.300 Q32PJ3 ORC3_BOVIN 99.579 0.997195 1.0014 ORC3 - Origin recognition complex subunit 3 - Bos taurus (Bovine) - ORC3 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. Indicus|evm.model.CM009499.1.301 Q0P5H7 SYRM_BOVIN 100.000 0.996546 1.00173 RARS2 - Probable arginine--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - RARS2 gene mitochondrion, arginine-tRNA ligase activity, arginyl-tRNA aminoacylation, mitochondrial translation Indicus|evm.model.CM009499.1.302 P78382 S35A1_HUMAN 95.252 0.994083 1.00297 SLC35A1 - CMP-sialic acid transporter - Homo sapiens (Human) - SLC35A1 gene Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function (PubMed:15576474). Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter. Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (By similarity). Indicus|evm.model.CM009499.1.303 Q29RL1 CF206_BOVIN 99.839 0.99679 1.00161 CFAP206 - Cilia- and flagella-associated protein 206 - Bos taurus (Bovine) - CFAP206 gene Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Required for the establishment of radial spokes in sperm flagella (By similarity). Indicus|evm.model.CM009499.1.304 A2VDV9 SMIM8_BOVIN 98.795 0.231638 3.64948 SMIM8 - Small integral membrane protein 8 - Bos taurus (Bovine) - SMIM8 gene Indicus|evm.model.CM009499.1.305 Q6PEY0 CXB7_HUMAN 90.783 0.802974 1.20628 GJB7 - Gap junction beta-7 protein - Homo sapiens (Human) - GJB7 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009499.1.306 O60281 ZN292_HUMAN 90.979 0.999265 0.998898 ZNF292 - Zinc finger protein 292 - Homo sapiens (Human) - ZNF292 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009499.1.307 A8D8X1 RL10_SHEEP 85.890 0.987805 0.766355 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009499.1.308 P01217 GLHA_BOVIN 100.000 0.983471 1.00833 CGA - Glycoprotein hormones alpha chain precursor - Bos taurus (Bovine) - CGA gene Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Indicus|evm.model.CM009499.1.309 Q6VB83 5HT1E_CAVPO 95.890 0.994536 1.00274 5HT1E - 5-hydroxytryptamine receptor 1E - Cavia porcellus (Guinea pig) - 5HT1E gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Indicus|evm.model.CM009499.1.311 Q9Y6A5 TACC3_HUMAN 84.615 0.506667 0.0894988 TACC3 - Transforming acidic coiled-coil-containing protein 3 - Homo sapiens (Human) - TACC3 gene Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). Indicus|evm.model.CM009499.1.313 O60506 HNRPQ_HUMAN 100.000 0.973357 0.903692 SYNCRIP - Heterogeneous nuclear ribonucleoprotein Q - Homo sapiens (Human) - SYNCRIP gene Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. Indicus|evm.model.CM009499.1.314 Q05927 5NTD_BOVIN 99.077 0.255924 2.20557 NT5E - 5'-nucleotidase precursor - Bos taurus (Bovine) - NT5E gene Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Indicus|evm.model.CM009499.1.315 Q05927 5NTD_BOVIN 99.602 0.862069 0.505226 NT5E - 5'-nucleotidase precursor - Bos taurus (Bovine) - NT5E gene Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Indicus|evm.model.CM009499.1.316 P34058 HS90B_RAT 70.376 0.971377 0.772099 Hsp90ab1 - Heat shock protein HSP 90-beta - Rattus norvegicus (Rat) - Hsp90ab1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10. Indicus|evm.model.CM009499.1.318 O95935 TBX18_HUMAN 95.752 0.996737 1.00988 TBX18 - T-box transcription factor TBX18 - Homo sapiens (Human) - TBX18 gene Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area. Indicus|evm.model.CM009499.1.319 O43812 DUX1_HUMAN 69.231 0.201893 1.86471 DUX1 - Double homeobox protein 1 - Homo sapiens (Human) - DUX1 gene Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'. Indicus|evm.model.CM009499.1.320 Q5TB80 CE162_HUMAN 80.426 0.998534 0.972202 CEP162 - Centrosomal protein of 162 kDa - Homo sapiens (Human) - CEP162 gene Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. Indicus|evm.model.CM009499.1.321 Q96G30 MRAP2_HUMAN 91.220 0.990291 1.00488 MRAP2 - Melanocortin-2 receptor accessory protein 2 - Homo sapiens (Human) - MRAP2 gene Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo. Indicus|evm.model.CM009499.1.322 Q32LH7 NB5R4_BOVIN 89.918 0.995455 0.846154 CYB5R4 - Cytochrome b5 reductase 4 - Bos taurus (Bovine) - CYB5R4 gene NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS) (By similarity). Indicus|evm.model.CM009499.1.323 Q5TAB7 RIPP2_HUMAN 76.636 0.518135 1.50781 RIPPLY2 - Protein ripply2 - Homo sapiens (Human) - RIPPLY2 gene Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity). Indicus|evm.model.CM009499.1.324 Q5RCP8 H2B2E_PONAB 90.090 0.763889 1.14286 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009499.1.326 A5D789 THMS1_BOVIN 100.000 0.0817308 0.648986 THEMIS - Protein THEMIS - Bos taurus (Bovine) - THEMIS gene Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. Indicus|evm.model.CM009499.1.327 Q15262 PTPRK_HUMAN 99.443 0.997222 1.00069 PTPRK - Receptor-type tyrosine-protein phosphatase kappa precursor - Homo sapiens (Human) - PTPRK gene Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. Indicus|evm.model.CM009499.1.328 O60361 NDK8_HUMAN 53.788 0.734694 1.07299 NME2P1 - Putative nucleoside diphosphate kinase - Homo sapiens (Human) - NME2P1 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Indicus|evm.model.CM009499.1.330 P24043 LAMA2_HUMAN 91.033 0.988379 0.523703 LAMA2 - Laminin subunit alpha-2 precursor - Homo sapiens (Human) - LAMA2 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Indicus|evm.model.CM009499.1.331 Q8N392 RHG18_HUMAN 86.486 0.921093 0.993967 ARHGAP18 - Rho GTPase-activating protein 18 - Homo sapiens (Human) - ARHGAP18 gene Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). Indicus|evm.model.CM009499.1.332 Q4PLJ0 NEDD8_RABIT 81.481 0.930233 1.06173 NEDD8 - NEDD8 precursor - Oryctolagus cuniculus (Rabbit) - NEDD8 gene Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). Indicus|evm.model.CM009499.1.333 Q8BLB7 LMBL3_MOUSE 98.230 0.143406 0.884485 L3mbtl3 - Lethal(3)malignant brain tumor-like protein 3 - Mus musculus (Mouse) - L3mbtl3 gene Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Required for normal maturation of myeloid progenitor cells. Indicus|evm.model.CM009499.1.334 Q8N6K7 SAMD3_HUMAN 87.500 0.894552 1.09423 SAMD3 - Sterile alpha motif domain-containing protein 3 - Homo sapiens (Human) - SAMD3 gene Indicus|evm.model.CM009499.1.336 Q86VY9 T200A_HUMAN 93.686 0.995935 1.00204 TMEM200A - Transmembrane protein 200A - Homo sapiens (Human) - TMEM200A gene Indicus|evm.model.CM009499.1.337 H3BR10 SMLR1_HUMAN 66.667 0.495935 1.14953 SMLR1 - Small leucine-rich protein 1 - Homo sapiens (Human) - SMLR1 gene Indicus|evm.model.CM009499.1.338 O43491 E41L2_HUMAN 83.412 0.998088 1.0408 EPB41L2 - Band 4.1-like protein 2 - Homo sapiens (Human) - EPB41L2 gene Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). Indicus|evm.model.CM009499.1.339 Q9P0M2 AKA7G_HUMAN 80.623 0.672131 1.22701 AKAP7 - A-kinase anchor protein 7 isoform gamma - Homo sapiens (Human) - AKAP7 gene Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. Indicus|evm.model.CM009499.1.340 Q2KJ64 ARGI1_BOVIN 100.000 0.993808 1.00311 ARG1 - Arginase-1 - Bos taurus (Bovine) - ARG1 gene cytoplasm, cytosol, arginase activity, manganese ion binding, arginine catabolic process to ornithine Indicus|evm.model.CM009499.1.341 Q9ULK4 MED23_HUMAN 96.711 0.996318 0.99269 MED23 - Mediator of RNA polymerase II transcription subunit 23 - Homo sapiens (Human) - MED23 gene Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. Indicus|evm.model.CM009499.1.342 P15396 ENPP3_BOVIN 99.657 0.997714 1.00114 ENPP3 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 - Bos taurus (Bovine) - ENPP3 gene Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity (By similarity). Indicus|evm.model.CM009499.1.343 P22413 ENPP1_HUMAN 87.514 0.997709 0.943784 ENPP1 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 - Homo sapiens (Human) - ENPP1 gene Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity). PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals (PubMed:11004006). Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP (PubMed:27467858, PubMed:8001561, PubMed:25344812). May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling (PubMed:27467858, PubMed:8001561). Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (By similarity). Appears to modulate insulin sensitivity and function (PubMed:10615944). Also involved in melanogenesis (PubMed:28964717). Also able to hydrolyze 2'-3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (PubMed:25344812). 2'-3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2'-3'-cGAMP hydrolysis is therefore unclear (PubMed:25344812). Not able to hydrolyze the 2'-3'-cGAMP linkage isomer 3'-3'-cGAMP (PubMed:25344812). Indicus|evm.model.CM009499.1.344 O18739 CCN2_BOVIN 100.000 0.994286 1.00287 CCN2 - CCN family member 2 precursor - Bos taurus (Bovine) - CCN2 gene Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). Indicus|evm.model.CM009499.1.347 A0JN40 KIF3C_BOVIN 80.000 0.831633 0.247475 KIF3C - Kinesin-like protein KIF3C - Bos taurus (Bovine) - KIF3C gene Microtubule-based anterograde translocator for membranous organelles. Indicus|evm.model.CM009499.1.348 Q6UVY6 MOXD1_HUMAN 94.194 0.646444 0.779772 MOXD1 - DBH-like monooxygenase protein 1 precursor - Homo sapiens (Human) - MOXD1 gene endoplasmic reticulum membrane, extracellular space, secretory granule membrane, copper ion binding, dopamine beta-monooxygenase activity, dopamine catabolic process, norepinephrine biosynthetic process, octopamine biosynthetic process Indicus|evm.model.CM009499.1.349 Q6YP21 KAT3_HUMAN 90.000 0.474403 0.645374 KYAT3 - Kynurenine--oxoglutarate transaminase 3 - Homo sapiens (Human) - KYAT3 gene Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). Indicus|evm.model.CM009499.1.350 Q3ZBT5 STX7_BOVIN 100.000 0.992366 1.00383 STX7 - Syntaxin-7 - Bos taurus (Bovine) - STX7 gene May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). Indicus|evm.model.CM009499.1.351 Q923Y2 TAA7A_RAT 77.273 0.330198 2.96927 Taar7a - Trace amine-associated receptor 7a - Rattus norvegicus (Rat) - Taar7a gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Indicus|evm.model.CM009499.1.352 Q5QD12 TAA7A_MOUSE 77.419 0.988372 0.960894 Taar7a - Trace amine-associated receptor 7a - Mus musculus (Mouse) - Taar7a gene Orphan olfactory receptor specific for trace amines. Indicus|evm.model.CM009499.1.353 Q969N4 TAAR8_HUMAN 48.168 0.981132 0.464912 TAAR8 - Trace amine-associated receptor 8 - Homo sapiens (Human) - TAAR8 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Indicus|evm.model.CM009499.1.354 Q5QD12 TAA7A_MOUSE 79.822 0.976744 0.960894 Taar7a - Trace amine-associated receptor 7a - Mus musculus (Mouse) - Taar7a gene Orphan olfactory receptor specific for trace amines. Indicus|evm.model.CM009499.1.355 Q923Y2 TAA7A_RAT 78.348 0.61552 1.5838 Taar7a - Trace amine-associated receptor 7a - Rattus norvegicus (Rat) - Taar7a gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Indicus|evm.model.CM009499.1.356 Q5W8W0 TAAR6_PANTR 86.510 0.899471 1.09565 TAAR6 - Trace amine-associated receptor 6 - Pan troglodytes (Chimpanzee) - TAAR6 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood (By similarity). Indicus|evm.model.CM009499.1.357 Q5QD12 TAA7A_MOUSE 78.886 0.988372 0.960894 Taar7a - Trace amine-associated receptor 7a - Mus musculus (Mouse) - Taar7a gene Orphan olfactory receptor specific for trace amines. Indicus|evm.model.CM009499.1.358 Q5QD12 TAA7A_MOUSE 79.403 0.97093 0.960894 Taar7a - Trace amine-associated receptor 7a - Mus musculus (Mouse) - Taar7a gene Orphan olfactory receptor specific for trace amines. Indicus|evm.model.CM009499.1.359 Q5QD13 TAAR6_MOUSE 84.928 0.99422 1.0029 Taar6 - Trace amine-associated receptor 6 - Mus musculus (Mouse) - Taar6 gene Orphan olfactory receptor specific for trace amines. Indicus|evm.model.CM009499.1.360 Q923Y5 TAAR6_RAT 81.443 0.329897 0.843478 Taar6 - Trace amine-associated receptor 6 - Rattus norvegicus (Rat) - Taar6 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Indicus|evm.model.CM009499.1.361 Q5QD12 TAA7A_MOUSE 78.592 0.988372 0.960894 Taar7a - Trace amine-associated receptor 7a - Mus musculus (Mouse) - Taar7a gene Orphan olfactory receptor specific for trace amines. Indicus|evm.model.CM009499.1.362 Q5W8W0 TAAR6_PANTR 87.097 0.991254 0.994203 TAAR6 - Trace amine-associated receptor 6 - Pan troglodytes (Chimpanzee) - TAAR6 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood (By similarity). Indicus|evm.model.CM009499.1.363 Q96RI8 TAAR6_HUMAN 82.474 0.326531 0.852174 TAAR6 - Trace amine-associated receptor 6 - Homo sapiens (Human) - TAAR6 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Indicus|evm.model.CM009499.1.364 Q5QD14 TAAR5_MOUSE 85.460 0.994083 1.00297 Taar5 - Trace amine-associated receptor 5 - Mus musculus (Mouse) - Taar5 gene Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male mice, playing a role in social behavior. Trimethylamine is present at high concentration in the urine of male mice after puberty and acts as an attractant. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. Indicus|evm.model.CM009499.1.365 Q58CQ9 VNN1_BOVIN 99.583 0.92471 1.01569 VNN1 - Pantetheinase precursor - Bos taurus (Bovine) - VNN1 gene Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Indicus|evm.model.CM009499.1.366 O95498 VNN2_HUMAN 79.231 0.996161 1.00192 VNN2 - Vascular non-inflammatory molecule 2 precursor - Homo sapiens (Human) - VNN2 gene Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. Indicus|evm.model.CM009499.1.367 Q6NT16 S18B1_HUMAN 84.163 0.950431 1.01754 SLC18B1 - MFS-type transporter SLC18B1 - Homo sapiens (Human) - SLC18B1 gene transmembrane transporter activity Indicus|evm.model.CM009499.1.368 P46405 RS12_PIG 100.000 0.984962 1.00758 RPS12 - 40S ribosomal protein S12 - Sus scrofa (Pig) - RPS12 gene cytosolic small ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009499.1.369 Q9Z191 EYA4_MOUSE 94.805 0.996759 1.00162 Eya4 - Eyes absent homolog 4 - Mus musculus (Mouse) - Eya4 gene Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). Indicus|evm.model.CM009499.1.371 Q5E9S3 TCF21_BOVIN 100.000 0.988889 1.00559 TCF21 - Transcription factor 21 - Bos taurus (Bovine) - TCF21 gene Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types (By similarity). Indicus|evm.model.CM009499.1.372 Q5R7U8 TBPL1_PONAB 100.000 0.989305 0.984211 TBPL1 - TATA box-binding protein-like 1 - Pongo abelii (Sumatran orangutan) - TBPL1 gene Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). Indicus|evm.model.CM009499.1.373 Q5J316 GTR12_BOVIN 91.897 0.996296 0.869565 SLC2A12 - Solute carrier family 2, facilitated glucose transporter member 12 - Bos taurus (Bovine) - SLC2A12 gene Insulin-independent facilitative glucose transporter. Indicus|evm.model.CM009499.1.374 A7MB74 SGK1_BOVIN 100.000 0.768501 1.22274 SGK1 - Serine/threonine-protein kinase Sgk1 - Bos taurus (Bovine) - SGK1 gene Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis (By similarity). Indicus|evm.model.CM009499.1.375 P62074 TIM10_RAT 87.671 0.972973 0.822222 Timm10 - Mitochondrial import inner membrane translocase subunit Tim10 - Rattus norvegicus (Rat) - Timm10 gene Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Indicus|evm.model.CM009499.1.376 Q5R997 SPIN1_PONAB 73.617 0.985981 0.816794 SPIN1 - Spindlin-1 - Pongo abelii (Sumatran orangutan) - SPIN1 gene Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. Indicus|evm.model.CM009499.1.377 Q0P5F9 AL8A1_BOVIN 99.589 0.995902 1.00205 ALDH8A1 - 2-aminomuconic semialdehyde dehydrogenase - Bos taurus (Bovine) - ALDH8A1 gene Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. Indicus|evm.model.CM009499.1.378 Q2KHZ2 HBS1L_BOVIN 99.854 0.997089 1.00146 HBS1L - HBS1-like protein - Bos taurus (Bovine) - HBS1L gene Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. Indicus|evm.model.CM009499.1.379 P46200 MYB_BOVIN 99.751 0.524934 1.19063 MYB - Transcriptional activator Myb - Bos taurus (Bovine) - MYB gene Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. Indicus|evm.model.CM009499.1.380 Q8N157 AHI1_HUMAN 81.052 0.998295 0.980769 AHI1 - Jouberin - Homo sapiens (Human) - AHI1 gene Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). Indicus|evm.model.CM009499.1.381 Q9QXQ1 PDE7B_MOUSE 93.096 0.995556 1.00897 Pde7b - cAMP-specific 3',5'-cyclic phosphodiesterase 7B - Mus musculus (Mouse) - Pde7b gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. Indicus|evm.model.CM009499.1.382 Q58CR1 MTFR2_BOVIN 99.449 0.266962 3.70492 MTFR2 - Mitochondrial fission regulator 2 - Bos taurus (Bovine) - MTFR2 gene May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). Indicus|evm.model.CM009499.1.383 Q14244 MAP7_HUMAN 81.756 0.939712 1.01869 MAP7 - Ensconsin - Homo sapiens (Human) - MAP7 gene Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. Indicus|evm.model.CM009499.1.384 Q99683 M3K5_HUMAN 94.196 0.998494 0.483261 MAP3K5 - Mitogen-activated protein kinase kinase kinase 5 - Homo sapiens (Human) - MAP3K5 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). Indicus|evm.model.CM009499.1.386 P97865 PEX7_MOUSE 89.172 0.965625 1.00629 Pex7 - Peroxisomal targeting signal 2 receptor - Mus musculus (Mouse) - Pex7 gene Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. Indicus|evm.model.CM009499.1.387 Q5M8T2 S35D3_HUMAN 91.017 0.995283 1.01923 SLC35D3 - Solute carrier family 35 member D3 - Homo sapiens (Human) - SLC35D3 gene May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules. Indicus|evm.model.CM009499.1.388 Q9UHF4 I20RA_HUMAN 75.522 0.937388 1.01085 IL20RA - Interleukin-20 receptor subunit alpha precursor - Homo sapiens (Human) - IL20RA gene The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26. Indicus|evm.model.CM009499.1.389 Q969J5 I22R2_HUMAN 65.779 0.991342 0.878327 IL22RA2 - Interleukin-22 receptor subunit alpha-2 precursor - Homo sapiens (Human) - IL22RA2 gene Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Indicus|evm.model.CM009499.1.390 P15260 INGR1_HUMAN 57.551 0.995717 0.95501 IFNGR1 - Interferon gamma receptor 1 precursor - Homo sapiens (Human) - IFNGR1 gene Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). Indicus|evm.model.CM009499.1.391 Q0VCA5 SAMH1_BOVIN 95.833 0.753165 0.268251 SAMHD1 - Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 - Bos taurus (Bovine) - SAMHD1 gene Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity (By similarity). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools. Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication. Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation. Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (By similarity). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). Indicus|evm.model.CM009499.1.393 Q7RTU3 OLIG3_HUMAN 98.897 0.992674 1.00368 OLIG3 - Oligodendrocyte transcription factor 3 - Homo sapiens (Human) - OLIG3 gene May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons. Indicus|evm.model.CM009499.1.394 Q4R8W3 TNAP3_MACFA 86.076 0.997439 0.988608 TNFAIP3 - Tumor necrosis factor alpha-induced protein 3 - Macaca fascicularis (Crab-eating macaque) - TNFAIP3 gene Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages (By similarity). Indicus|evm.model.CM009499.1.395 Q96FX8 PERP_HUMAN 88.601 0.989189 0.958549 PERP - p53 apoptosis effector related to PMP-22 - Homo sapiens (Human) - PERP gene Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). Indicus|evm.model.CM009499.1.396 Q5TH69 BIG3_HUMAN 94.490 0.999081 1 ARFGEF3 - Brefeldin A-inhibited guanine nucleotide-exchange protein 3 - Homo sapiens (Human) - ARFGEF3 gene Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). Indicus|evm.model.CM009499.1.397 A0A1B0GU29 SIM28_HUMAN 79.592 0.879518 1.09211 SMIM28 - Small integral membrane protein 28 - Homo sapiens (Human) - SMIM28 gene Indicus|evm.model.CM009499.1.398 Q9Y5Z4 HEBP2_HUMAN 88.780 0.990291 1.00488 HEBP2 - Heme-binding protein 2 - Homo sapiens (Human) - HEBP2 gene Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Indicus|evm.model.CM009499.1.399 Q5SYE7 NHSL1_HUMAN 73.962 0.940564 1.01366 NHSL1 - NHS-like protein 1 - Homo sapiens (Human) - NHSL1 gene cell differentiation Indicus|evm.model.CM009499.1.400 Q8IWP9 CC28A_HUMAN 81.648 0.967153 1 CCDC28A - Coiled-coil domain-containing protein 28A - Homo sapiens (Human) - CCDC28A gene Indicus|evm.model.CM009499.1.401 Q008S8 ECT2L_HUMAN 83.105 0.985417 1.06195 ECT2L - Epithelial cell-transforming sequence 2 oncogene-like - Homo sapiens (Human) - ECT2L gene May act as a guanine nucleotide exchange factor (GEF). Indicus|evm.model.CM009499.1.402 Q96D71 REPS1_HUMAN 93.844 0.997406 0.968593 REPS1 - RalBP1-associated Eps domain-containing protein 1 - Homo sapiens (Human) - REPS1 gene May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. Indicus|evm.model.CM009499.1.403 Q3ZBN0 ABRAL_BOVIN 100.000 0.769231 1.28395 ABRACL - Costars family protein ABRACL - Bos taurus (Bovine) - ABRACL gene regulation of actin filament-based process Indicus|evm.model.CM009499.1.404 Q9UBI9 HDC_HUMAN 96.272 0.991285 0.845304 HECA - Headcase protein homolog - Homo sapiens (Human) - HECA gene May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. Indicus|evm.model.CM009499.1.405 Q8N3L3 TXLNB_HUMAN 67.694 0.997199 1.04386 TXLNB - Beta-taxilin - Homo sapiens (Human) - TXLNB gene Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic. Indicus|evm.model.CM009499.1.406 Q0VCT9 CITE2_BOVIN 100.000 0.992701 1.00366 CITED2 - Cbp/p300-interacting transactivator 2 - Bos taurus (Bovine) - CITED2 gene Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. Indicus|evm.model.CM009499.1.408 Q96MW7 TIGD1_HUMAN 58.824 0.960784 0.0862944 TIGD1 - Tigger transposable element-derived protein 1 - Homo sapiens (Human) - TIGD1 gene nucleus, DNA binding Indicus|evm.model.CM009499.1.409 A6NMX2 I4E1B_HUMAN 72.581 0.858268 0.524793 EIF4E1B - Eukaryotic translation initiation factor 4E type 1B - Homo sapiens (Human) - EIF4E1B gene Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure. Indicus|evm.model.CM009499.1.411 P28336 NMBR_HUMAN 91.538 0.994885 1.00256 NMBR - Neuromedin-B receptor - Homo sapiens (Human) - NMBR gene Receptor for neuromedin-B. Indicus|evm.model.CM009499.1.412 Q32L63 VTA1_BOVIN 99.674 0.993506 1.00326 VTA1 - Vacuolar protein sorting-associated protein VTA1 homolog - Bos taurus (Bovine) - VTA1 gene Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Indicus|evm.model.CM009499.1.413 Q86SQ4 AGRG6_HUMAN 86.178 0.96 1.02375 ADGRG6 - Adhesion G-protein coupled receptor G6 precursor - Homo sapiens (Human) - ADGRG6 gene G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). Indicus|evm.model.CM009499.1.414 P31629 ZEP2_HUMAN 90.008 0.999181 0.998774 HIVEP2 - Transcription factor HIVEP2 - Homo sapiens (Human) - HIVEP2 gene This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. Indicus|evm.model.CM009499.1.416 Q9NVV5 AIG1_HUMAN 97.059 0.991632 1.0042 AIG1 - Androgen-induced gene 1 protein - Homo sapiens (Human) - AIG1 gene Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Indicus|evm.model.CM009499.1.417 Q5E9J7 ADAT2_BOVIN 99.476 0.989583 1.00524 DEADC1 - tRNA-specific adenosine deaminase 2 - Bos taurus (Bovine) - DEADC1 gene Probably participates in deamination of adenosine-34 to inosine in many tRNAs. Indicus|evm.model.CM009499.1.418 A6H7C2 PEX3_BOVIN 100.000 0.994652 1.00268 PEX3 - Peroxisomal biogenesis factor 3 - Bos taurus (Bovine) - PEX3 gene Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (By similarity). Indicus|evm.model.CM009499.1.419 Q9BTY2 FUCO2_HUMAN 86.788 0.939914 0.997859 FUCA2 - Plasma alpha-L-fucosidase precursor - Homo sapiens (Human) - FUCA2 gene Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Indicus|evm.model.CM009499.1.420 P62025 PHAR2_RAT 88.000 0.233177 1.12302 Phactr2 - Phosphatase and actin regulator 2 - Rattus norvegicus (Rat) - Phactr2 gene actin binding, actin cytoskeleton organization Indicus|evm.model.CM009499.1.421 Q0VC06 LTV1_BOVIN 100.000 0.995798 1.00211 LTV1 - Protein LTV1 homolog - Bos taurus (Bovine) - LTV1 gene cytosol, nucleus, preribosome, small subunit precursor, ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus Indicus|evm.model.CM009499.1.422 Q32KN7 ZC21B_BOVIN 99.095 0.990991 1.0137 ZC2HC1B - Zinc finger C2HC domain-containing protein 1B - Bos taurus (Bovine) - ZC2HC1B gene Indicus|evm.model.CM009499.1.423 Q2I689 PLAL1_PIG 88.769 0.995652 0.993521 PLAGL1 - Zinc finger protein PLAGL1 - Sus scrofa (Pig) - PLAGL1 gene Acts as a transcriptional activator. Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide. Indicus|evm.model.CM009499.1.424 Q9BWJ5 SF3B5_HUMAN 100.000 0.977011 1.01163 SF3B5 - Splicing factor 3B subunit 5 - Homo sapiens (Human) - SF3B5 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Indicus|evm.model.CM009499.1.425 O75558 STX11_HUMAN 83.217 0.989583 1.00348 STX11 - Syntaxin-11 - Homo sapiens (Human) - STX11 gene SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Indicus|evm.model.CM009499.1.426 P46939 UTRO_HUMAN 90.073 0.997573 0.72007 UTRN - Utrophin - Homo sapiens (Human) - UTRN gene May play a role in anchoring the cytoskeleton to the plasma membrane. Indicus|evm.model.CM009499.1.427 P46939 UTRO_HUMAN 96.288 0.98123 0.279348 UTRN - Utrophin - Homo sapiens (Human) - UTRN gene May play a role in anchoring the cytoskeleton to the plasma membrane. Indicus|evm.model.CM009499.1.428 Q93079 H2B1H_HUMAN 91.262 0.962264 0.84127 H2BC9 - Histone H2B type 1-H - Homo sapiens (Human) - H2BC9 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009499.1.430 Q1M199 EPM2A_CANLF 91.667 0.983471 0.365559 EPM2A - Laforin - Canis lupus familiaris (Dog) - EPM2A gene Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro). Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. Indicus|evm.model.CM009499.1.431 Q8TB52 FBX30_HUMAN 90.909 0.997319 1.00134 FBXO30 - F-box only protein 30 - Homo sapiens (Human) - FBXO30 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. Indicus|evm.model.CM009499.1.432 Q149N8 SHPRH_HUMAN 90.569 0.998814 1.00178 SHPRH - E3 ubiquitin-protein ligase SHPRH - Homo sapiens (Human) - SHPRH gene E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. Indicus|evm.model.CM009499.1.434 Q06AU5 RAB32_PIG 93.011 0.939086 0.871681 RAB32 - Ras-related protein Rab-32 - Sus scrofa (Pig) - RAB32 gene Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Indicus|evm.model.CM009499.1.435 Q1RMS8 FBX25_BOVIN 90.299 0.624413 0.596639 FBXO25 - F-box only protein 25 - Bos taurus (Bovine) - FBXO25 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). Indicus|evm.model.CM009499.1.436 Q8N7X0 ADGB_HUMAN 83.677 0.977612 0.321536 ADGB - Androglobin - Homo sapiens (Human) - ADGB gene Indicus|evm.model.CM009499.1.437 Q8N7X0 ADGB_HUMAN 77.118 0.986471 0.532094 ADGB - Androglobin - Homo sapiens (Human) - ADGB gene Indicus|evm.model.CM009499.1.438 Q5T5C0 STXB5_HUMAN 97.830 0.998265 1.00174 STXBP5 - Syntaxin-binding protein 5 - Homo sapiens (Human) - STXBP5 gene Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). Indicus|evm.model.CM009499.1.439 Q9BZM4 ULBP3_HUMAN 47.788 0.931624 0.479508 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Indicus|evm.model.CM009499.1.440 A6QQT9 HACL2_BOVIN 84.416 0.949367 0.125 ILVBL - 2-hydroxyacyl-CoA lyase 2 - Bos taurus (Bovine) - ILVBL gene Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. Indicus|evm.model.CM009499.1.441 Q09YL6 SAMD5_BOVIN 100.000 0.950617 0.925714 SAMD5 - Sterile alpha motif domain-containing protein 5 - Bos taurus (Bovine) - SAMD5 gene cytoplasm Indicus|evm.model.CM009499.1.442 Q9BZM4 ULBP3_HUMAN 48.182 0.876 1.02459 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Indicus|evm.model.CM009499.1.443 O94885 SASH1_HUMAN 89.885 0.997521 0.970329 SASH1 - SAM and SH3 domain-containing protein 1 - Homo sapiens (Human) - SASH1 gene Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). Indicus|evm.model.CM009499.1.444 Q9Y2C2 UST_HUMAN 96.121 0.807692 0.704433 UST - Uronyl 2-sulfotransferase - Homo sapiens (Human) - UST gene Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin. Indicus|evm.model.CM009499.1.445 Q9Y2C2 UST_HUMAN 94.253 0.716667 0.295567 UST - Uronyl 2-sulfotransferase - Homo sapiens (Human) - UST gene Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin. Indicus|evm.model.CM009499.1.446 Q9NYJ8 TAB2_HUMAN 96.681 0.997118 1.00144 TAB2 - TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 - Homo sapiens (Human) - TAB2 gene Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:22158122). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). Indicus|evm.model.CM009499.1.447 A2A288 ZC12D_HUMAN 85.606 0.674359 0.740038 ZC3H12D - Probable ribonuclease ZC3H12D - Homo sapiens (Human) - ZC3H12D gene May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561). Indicus|evm.model.CM009499.1.448 Q8WUA2 PPIL4_HUMAN 97.561 0.995943 1.00203 PPIL4 - Peptidyl-prolyl cis-trans isomerase-like 4 - Homo sapiens (Human) - PPIL4 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Indicus|evm.model.CM009499.1.449 Q5RBQ2 GINM1_PONAB 87.311 0.993939 1 GINM1 - Glycoprotein integral membrane protein 1 precursor - Pongo abelii (Sumatran orangutan) - GINM1 gene Indicus|evm.model.CM009499.1.450 O75449 KTNA1_HUMAN 97.149 0.995935 1.00204 KATNA1 - Katanin p60 ATPase-containing subunit A1 - Homo sapiens (Human) - KATNA1 gene Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. Indicus|evm.model.CM009499.1.452 O95835 LATS1_HUMAN 94.867 0.998221 0.99469 LATS1 - Serine/threonine-protein kinase LATS1 - Homo sapiens (Human) - LATS1 gene Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Indicus|evm.model.CM009499.1.453 Q8NFH3 NUP43_HUMAN 93.391 0.33953 2.68947 NUP43 - Nucleoporin Nup43 - Homo sapiens (Human) - NUP43 gene Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. Indicus|evm.model.CM009499.1.454 P15246 PIMT_BOVIN 100.000 0.672673 1.46696 PCMT1 - Protein-L-isoaspartate(D-aspartate) O-methyltransferase - Bos taurus (Bovine) - PCMT1 gene Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein. Indicus|evm.model.CM009499.1.455 Q86VZ4 LRP11_HUMAN 79.352 0.907063 0.538 LRP11 - Low-density lipoprotein receptor-related protein 11 precursor - Homo sapiens (Human) - LRP11 gene plasma membrane, phosphoprotein binding Indicus|evm.model.CM009499.1.456 Q2YDJ0 NUSAP_BOVIN 97.849 0.99568 0.995699 NUSAP1 - Nucleolar and spindle-associated protein 1 - Bos taurus (Bovine) - NUSAP1 gene Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them (By similarity). Indicus|evm.model.CM009499.1.457 Q86VZ4 LRP11_HUMAN 72.459 0.986301 0.584 LRP11 - Low-density lipoprotein receptor-related protein 11 precursor - Homo sapiens (Human) - LRP11 gene plasma membrane, phosphoprotein binding Indicus|evm.model.CM009499.1.460 Q9BZM5 ULBP2_HUMAN 47.059 0.439791 0.776423 ULBP2 - UL16-binding protein 2 precursor - Homo sapiens (Human) - ULBP2 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Indicus|evm.model.CM009499.1.461 Q9BZM4 ULBP3_HUMAN 44.565 0.535294 0.696721 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Indicus|evm.model.CM009499.1.462 Q9BZM4 ULBP3_HUMAN 56.098 0.153846 1.06557 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Indicus|evm.model.CM009499.1.463 Q9BZM6 ULBP1_HUMAN 53.107 0.647059 1.11475 ULBP1 - UL16-binding protein 1 precursor - Homo sapiens (Human) - ULBP1 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Indicus|evm.model.CM009499.1.464 Q9BZM4 ULBP3_HUMAN 48.485 0.693662 1.16393 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Indicus|evm.model.CM009499.1.465 Q9BZM4 ULBP3_HUMAN 47.642 0.850806 1.01639 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Indicus|evm.model.CM009499.1.466 Q9BZM4 ULBP3_HUMAN 47.059 0.712766 0.385246 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Indicus|evm.model.CM009499.1.467 Q8TAE6 PP14C_HUMAN 89.423 0.762963 0.818182 PPP1R14C - Protein phosphatase 1 regulatory subunit 14C - Homo sapiens (Human) - PPP1R14C gene Inhibitor of the PP1 regulatory subunit PPP1CA. Indicus|evm.model.CM009499.1.468 Q8TAE6 PP14C_HUMAN 93.023 0.403846 0.630303 PPP1R14C - Protein phosphatase 1 regulatory subunit 14C - Homo sapiens (Human) - PPP1R14C gene Inhibitor of the PP1 regulatory subunit PPP1CA. Indicus|evm.model.CM009499.1.469 Q6TA49 IYD1_PIG 88.235 0.366485 2.53979 IYD - Iodotyrosine deiodinase 1 precursor - Sus scrofa (Pig) - IYD gene Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT) (PubMed:15289438). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. Indicus|evm.model.CM009499.1.470 Q9ULL1 PKHG1_HUMAN 81.479 0.959638 1.03755 PLEKHG1 - Pleckstrin homology domain-containing family G member 1 - Homo sapiens (Human) - PLEKHG1 gene nucleoplasm Indicus|evm.model.CM009499.1.471 Q0VCR7 C1TM_BOVIN 96.089 0.951832 0.979487 MTHFD1L - Monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor - Bos taurus (Bovine) - MTHFD1L gene May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. Indicus|evm.model.CM009499.1.473 Q02952 AKA12_HUMAN 63.201 0.992736 0.927048 AKAP12 - A-kinase anchor protein 12 - Homo sapiens (Human) - AKAP12 gene Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). Indicus|evm.model.CM009499.1.474 Q8N680 ZBTB2_HUMAN 96.498 0.996117 1.00195 ZBTB2 - Zinc finger and BTB domain-containing protein 2 - Homo sapiens (Human) - ZBTB2 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009499.1.475 Q9NWS8 RMND1_HUMAN 86.414 0.984581 1.01114 RMND1 - Required for meiotic nuclear division protein 1 homolog precursor - Homo sapiens (Human) - RMND1 gene Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome (PubMed:23022098, PubMed:25604853). Indicus|evm.model.CM009499.1.476 A3KMX8 ARMT1_BOVIN 99.773 0.995475 1.00227 ARMT1 - Damage-control phosphatase ARMT1 - Bos taurus (Bovine) - ARMT1 gene Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity). Indicus|evm.model.CM009499.1.477 Q8IYT3 CC170_HUMAN 72.662 0.982866 0.897902 CCDC170 - Coiled-coil domain-containing protein 170 - Homo sapiens (Human) - CCDC170 gene Plays a role in Golgi-associated microtubules organization and stabilization. Indicus|evm.model.CM009499.1.478 P49884 ESR1_BOVIN 100.000 0.971154 0.174497 ESR1 - Estrogen receptor - Bos taurus (Bovine) - ESR1 gene Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity). Indicus|evm.model.CM009499.1.479 P49885 ESR1_SHEEP 98.947 0.810345 1.04505 ESR1 - Estrogen receptor - Ovis aries (Sheep) - ESR1 gene Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity). Indicus|evm.model.CM009499.1.480 Q19PY3 RTCB_PIG 86.842 0.974138 0.229703 RTCB - RNA-splicing ligase RtcB homolog - Sus scrofa (Pig) - RTCB gene Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Indicus|evm.model.CM009499.1.481 A9CB42 RTCB_PAPAN 73.267 0.980392 0.20198 RTCB - RNA-splicing ligase RtcB homolog - Papio anubis (Olive baboon) - RTCB gene Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Indicus|evm.model.CM009499.1.482 P49884 ESR1_BOVIN 100.000 0.993994 0.558725 ESR1 - Estrogen receptor - Bos taurus (Bovine) - ESR1 gene Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity). Indicus|evm.model.CM009499.1.483 Q8NF91 SYNE1_HUMAN 89.976 0.999773 1.00034 SYNE1 - Nesprin-1 - Homo sapiens (Human) - SYNE1 gene Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. Indicus|evm.model.CM009499.1.484 Q8N699 MYCT1_HUMAN 86.826 0.988024 0.710638 MYCT1 - Myc target protein 1 - Homo sapiens (Human) - MYCT1 gene May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity). Indicus|evm.model.CM009499.1.485 P81401 VIP_BOVIN 99.412 0.988304 1.00588 VIP - VIP peptides precursor - Bos taurus (Bovine) - VIP gene VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. Indicus|evm.model.CM009499.1.487 Q2KI15 RF1ML_BOVIN 99.737 0.994751 1.00263 MTRF1L - Peptide chain release factor 1-like, mitochondrial precursor - Bos taurus (Bovine) - MTRF1L gene Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG. Indicus|evm.model.CM009499.1.488 Q9UGC6 RGS17_HUMAN 82.857 0.98895 0.861905 RGS17 - Regulator of G-protein signaling 17 - Homo sapiens (Human) - RGS17 gene Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). Indicus|evm.model.CM009499.1.489 Q6IEV9 OR4CB_HUMAN 54.286 0.832168 0.46129 OR4C11 - Olfactory receptor 4C11 - Homo sapiens (Human) - OR4C11 gene Odorant receptor. Indicus|evm.model.CM009499.1.490 Q8NH72 OR4C6_HUMAN 67.857 0.990323 1.00324 OR4C6 - Olfactory receptor 4C6 - Homo sapiens (Human) - OR4C6 gene Odorant receptor. Indicus|evm.model.CM009499.1.492 P19338 NUCL_HUMAN 77.778 0.821429 0.197183 NCL - Nucleolin - Homo sapiens (Human) - NCL gene Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Indicus|evm.model.CM009499.1.494 O08812 CTR3_RAT 59.542 0.643564 0.326333 Slc7a3 - Cationic amino acid transporter 3 - Rattus norvegicus (Rat) - Slc7a3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009499.1.495 P79350 OPRM_BOVIN 96.040 0.793651 0.314214 OPRM1 - Mu-type opioid receptor - Bos taurus (Bovine) - OPRM1 gene Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10581406). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis (By similarity). Indicus|evm.model.CM009499.1.496 P79350 OPRM_BOVIN 99.308 0.982935 0.730673 OPRM1 - Mu-type opioid receptor - Bos taurus (Bovine) - OPRM1 gene Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10581406). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis (By similarity). Indicus|evm.model.CM009499.1.497 Q8WWN9 ICEF1_HUMAN 80.182 0.993135 1 IPCEF1 - Interactor protein for cytohesin exchange factors 1 - Homo sapiens (Human) - IPCEF1 gene Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. Indicus|evm.model.CM009499.1.499 G9CGD6 CNIPF_HUMAN 94.967 0.81982 0.617353 CNK3/IPCEF1 - CNK3/IPCEF1 fusion protein - Homo sapiens (Human) - CNK3/IPCEF1 gene Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. Indicus|evm.model.CM009499.1.500 P18437 HMGN2_RAT 83.333 0.525641 0.866667 Hmgn2 - Non-histone chromosomal protein HMG-17 - Rattus norvegicus (Rat) - Hmgn2 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). Indicus|evm.model.CM009499.1.502 Q9UPN6 SCAF8_HUMAN 95.279 0.998424 0.998426 SCAF8 - SR-related and CTD-associated factor 8 - Homo sapiens (Human) - SCAF8 gene Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839). Indicus|evm.model.CM009499.1.504 Q8IVF5 TIAM2_HUMAN 86.792 0.358682 0.92769 TIAM2 - Rho guanine nucleotide exchange factor TIAM2 - Homo sapiens (Human) - TIAM2 gene Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. Indicus|evm.model.CM009499.1.505 Q2TBQ0 TFB1M_BOVIN 100.000 0.994152 1.00293 TFB1M - Mitochondrial dimethyladenosine transferase 1 precursor - Bos taurus (Bovine) - TFB1M gene S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity). Indicus|evm.model.CM009499.1.506 Q9HBY0 NOX3_HUMAN 82.752 0.955307 0.945423 NOX3 - NADPH oxidase 3 - Homo sapiens (Human) - NOX3 gene NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Indicus|evm.model.CM009499.1.507 Q96LI6 HSFY1_HUMAN 49.802 0.873684 0.710723 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009499.1.509 P00348 HCDH_PIG 85.446 0.972477 0.694268 HADH - Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor - Sus scrofa (Pig) - HADH gene Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:9593854, PubMed:2817332). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Indicus|evm.model.CM009499.1.511 E9Q4N7 ARI1B_MOUSE 93.371 0.995516 0.795009 Arid1b - AT-rich interactive domain-containing protein 1B - Mus musculus (Mouse) - Arid1b gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Binds DNA non-specifically. Indicus|evm.model.CM009499.1.512 Q5R987 TM242_PONAB 87.943 0.985915 1.00709 TMEM242 - Transmembrane protein 242 - Pongo abelii (Sumatran orangutan) - TMEM242 gene Indicus|evm.model.CM009499.1.513 Q8IZN3 ZDH14_HUMAN 92.379 0.995215 0.856557 ZDHHC14 - Palmitoyltransferase ZDHHC14 - Homo sapiens (Human) - ZDHHC14 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and thereby regulate G protein-coupled receptor signaling (PubMed:27481942). May play a role in cell differentiation and apoptosis (PubMed:21151021, PubMed:24407904). Indicus|evm.model.CM009499.1.514 Q9Y5X1 SNX9_HUMAN 92.687 0.996593 0.986555 SNX9 - Sorting nexin-9 - Homo sapiens (Human) - SNX9 gene Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. Indicus|evm.model.CM009499.1.515 O15056 SYNJ2_HUMAN 81.342 0.988568 0.993984 SYNJ2 - Synaptojanin-2 - Homo sapiens (Human) - SYNJ2 gene Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. Indicus|evm.model.CM009499.1.516 Q2TBM9 SRAC1_BOVIN 99.694 0.996947 1.00153 SERAC1 - Protein SERAC1 - Bos taurus (Bovine) - SERAC1 gene Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity). Indicus|evm.model.CM009499.1.517 Q6ZYL4 TF2H5_HUMAN 95.161 0.709302 1.21127 GTF2H5 - General transcription factor IIH subunit 5 - Homo sapiens (Human) - GTF2H5 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. Indicus|evm.model.CM009499.1.518 Q9JIL5 TULP4_MOUSE 93.730 0.664804 0.925663 Tulp4 - Tubby-related protein 4 - Mus musculus (Mouse) - Tulp4 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009499.1.519 Q9P2C4 TM181_HUMAN 87.791 0.995943 0.805556 TMEM181 - Transmembrane protein 181 - Homo sapiens (Human) - TMEM181 gene Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication. Indicus|evm.model.CM009499.1.520 P63172 DYLT1_HUMAN 100.000 0.982456 1.00885 DYNLT1 - Dynein light chain Tctex-type 1 - Homo sapiens (Human) - DYNLT1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. Indicus|evm.model.CM009499.1.521 Q4VX76 SYTL3_HUMAN 77.778 0.996732 1.00328 SYTL3 - Synaptotagmin-like protein 3 - Homo sapiens (Human) - SYTL3 gene May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). Indicus|evm.model.CM009499.1.522 P31976 EZRI_BOVIN 100.000 0.996564 1.00172 EZR - Ezrin - Bos taurus (Bovine) - EZR gene Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). Indicus|evm.model.CM009499.1.523 A8E4N3 RSPH3_BOVIN 98.845 0.996705 1.00165 RSPH3 - Radial spoke head protein 3 homolog - Bos taurus (Bovine) - RSPH3 gene Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity). Indicus|evm.model.CM009499.1.524 P62246 RS15A_RAT 70.667 0.948718 0.6 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Indicus|evm.model.CM009499.1.525 Q8N103 TAGAP_HUMAN 65.395 0.694849 1.40766 TAGAP - T-cell activation Rho GTPase-activating protein - Homo sapiens (Human) - TAGAP gene May function as a GTPase-activating protein and may play important roles during T-cell activation. Indicus|evm.model.CM009499.1.526 Q4ZHG4 FNDC1_HUMAN 90.885 0.223977 0.902851 FNDC1 - Fibronectin type III domain-containing protein 1 precursor - Homo sapiens (Human) - FNDC1 gene May be an activator of G protein signaling. Indicus|evm.model.CM009499.1.528 A6NHX0 CAST2_HUMAN 60.417 0.610236 0.772036 CASTOR2 - Cytosolic arginine sensor for mTORC1 subunit 2 - Homo sapiens (Human) - CASTOR2 gene Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. Indicus|evm.model.CM009499.1.529 P41976 SODM_BOVIN 98.261 0.22179 2.31532 SOD2 - Superoxide dismutase [Mn], mitochondrial precursor - Bos taurus (Bovine) - SOD2 gene Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Indicus|evm.model.CM009499.1.530 Q9BWD1 THIC_HUMAN 90.152 0.992462 1.00252 ACAT2 - Acetyl-CoA acetyltransferase, cytosolic - Homo sapiens (Human) - ACAT2 gene Involved in the biosynthetic pathway of cholesterol. Indicus|evm.model.CM009499.1.531 Q32L40 TCPA_BOVIN 99.820 0.996409 1.0018 TCP1 - T-complex protein 1 subunit alpha - Bos taurus (Bovine) - TCP1 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.CM009499.1.532 Q3ZBR7 RM18_BOVIN 100.000 0.98895 1.00556 MRPL18 - 39S ribosomal protein L18, mitochondrial precursor - Bos taurus (Bovine) - MRPL18 gene Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity). Indicus|evm.model.CM009499.1.533 B2RXZ1 PNDC1_MOUSE 86.822 0.946691 1.02448 Pnldc1 - Poly(A)-specific ribonuclease PNLDC1 - Mus musculus (Mouse) - Pnldc1 gene 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (PubMed:27515512). Indicus|evm.model.CM009499.1.534 P04201 MAS_HUMAN 87.385 0.993865 1.00308 MAS1 - Proto-oncogene Mas - Homo sapiens (Human) - MAS1 gene Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. Indicus|evm.model.CM009499.1.536 P08169 MPRI_BOVIN 100.000 0.922252 0.14926 IGF2R - Cation-independent mannose-6-phosphate receptor precursor - Bos taurus (Bovine) - IGF2R gene Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. Indicus|evm.model.CM009499.1.537 P08169 MPRI_BOVIN 98.693 0.858757 0.0708283 IGF2R - Cation-independent mannose-6-phosphate receptor precursor - Bos taurus (Bovine) - IGF2R gene Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. Indicus|evm.model.CM009499.1.538 A7MBE0 S22A1_BOVIN 100.000 0.230045 4.33925 SLC22A1 - Solute carrier family 22 member 1 - Bos taurus (Bovine) - SLC22A1 gene Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase (By similarity). Indicus|evm.model.CM009499.1.539 O02713 S22A2_PIG 88.448 0.996364 0.99278 SLC22A2 - Solute carrier family 22 member 2 - Sus scrofa (Pig) - SLC22A2 gene Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity (By similarity). Indicus|evm.model.CM009499.1.540 O75751 S22A3_HUMAN 95.411 0.901747 0.823741 SLC22A3 - Solute carrier family 22 member 3 - Homo sapiens (Human) - SLC22A3 gene Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. Indicus|evm.model.CM009499.1.541 P06868 PLMN_BOVIN 99.130 0.997519 0.992611 PLG - Plasminogen precursor - Bos taurus (Bovine) - PLG gene Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity). Indicus|evm.model.CM009499.1.543 Q5E9R2 PLCD_BOVIN 99.735 0.87067 1.1455 AGPAT4 - 1-acyl-sn-glycerol-3-phosphate acyltransferase delta - Bos taurus (Bovine) - AGPAT4 gene Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity). Indicus|evm.model.CM009499.1.545 O60260 PRKN_HUMAN 89.547 0.993056 0.619355 PRKN - E3 ubiquitin-protein ligase parkin - Homo sapiens (Human) - PRKN gene Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536, PubMed:32047033, PubMed:29311685, PubMed:22396657). Substrates include SYT11 and VDAC1 (PubMed:32047033, PubMed:29311685). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536, PubMed:22396657). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951, PubMed:32047033, PubMed:25474007). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11431533, PubMed:11590439, PubMed:15105460, PubMed:19229105, PubMed:15728840). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:32047033, PubMed:19029340, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:18957282, PubMed:21376232, PubMed:22396657, PubMed:24660806, PubMed:25474007, PubMed:24784582, PubMed:11439185, PubMed:22082830, PubMed:23933751). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:32047033, PubMed:19029340, PubMed:19801972, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:21376232, PubMed:22396657, PubMed:11439185, PubMed:22082830, PubMed:23933751, PubMed:33499712). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:24660806, PubMed:25474007, PubMed:24784582, PubMed:25527291). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:22396657, PubMed:23933751). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (PubMed:25621951, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:23620051). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:23620051). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed:21376232). Limits the production of reactive oxygen species (ROS) (PubMed:18541373). Regulates cyclin-E during neuronal apoptosis (PubMed:12628165). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (PubMed:12719539). Indicus|evm.model.CM009499.1.546 Q96M98 PACRG_HUMAN 91.284 0.791971 0.925676 PACRG - Parkin coregulated gene protein - Homo sapiens (Human) - PACRG gene Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. Indicus|evm.model.CM009499.1.549 Q5W9D5 QKI_PIG 97.203 0.992832 0.818182 QKI - Protein quaking - Sus scrofa (Pig) - QKI gene RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). Indicus|evm.model.CM009499.1.554 Q9H3K2 GHITM_HUMAN 83.768 0.99373 0.924638 GHITM - Growth hormone-inducible transmembrane protein precursor - Homo sapiens (Human) - GHITM gene Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. Indicus|evm.model.CM009499.1.556 Q5T5N4 CF118_HUMAN 57.872 0.932347 1.00853 C6orf118 - Uncharacterized protein C6orf118 - Homo sapiens (Human) - C6orf118 gene Indicus|evm.model.CM009499.1.557 Q9Y233 PDE10_HUMAN 95.046 0.830435 1.181 PDE10A - cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A - Homo sapiens (Human) - PDE10A gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition. Indicus|evm.model.CM009499.1.561 Q9GL27 TBXT_CANLF 85.242 0.995604 1.04598 TBXT - T-box transcription factor T - Canis lupus familiaris (Dog) - TBXT gene Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. Indicus|evm.model.CM009499.1.565 Q8WV19 SFT2A_HUMAN 94.340 0.755981 1.31447 SFT2D1 - Vesicle transport protein SFT2A - Homo sapiens (Human) - SFT2D1 gene May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Indicus|evm.model.CM009499.1.567 Q3ZCG2 MPC1_BOVIN 100.000 0.981818 1.00917 MPC1 - Mitochondrial pyruvate carrier 1 - Bos taurus (Bovine) - MPC1 gene Mediates the uptake of pyruvate into mitochondria. Indicus|evm.model.CM009499.1.569 Q15349 KS6A2_HUMAN 96.862 0.997275 1.00136 RPS6KA2 - Ribosomal protein S6 kinase alpha-2 - Homo sapiens (Human) - RPS6KA2 gene Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. Indicus|evm.model.CM009499.1.572 Q7M329 RNT2_PIG 66.667 0.862903 1.24 RNASET2 - Ribonuclease T2 - Sus scrofa (Pig) - RNASET2 gene Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs. Indicus|evm.model.CM009499.1.573 Q2YDD1 CEP43_BOVIN 96.606 0.756436 1.26566 CEP43 - Centrosomal protein 43 - Bos taurus (Bovine) - CEP43 gene Required for anchoring microtubules to the centrosomes. Required for ciliation. Indicus|evm.model.CM009499.1.576 P51684 CCR6_HUMAN 78.284 0.84897 1.16845 CCR6 - C-C chemokine receptor type 6 - Homo sapiens (Human) - CCR6 gene Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988). Indicus|evm.model.CM009499.1.577 O00270 GPR31_HUMAN 61.950 0.984026 0.981191 GPR31 - 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor - Homo sapiens (Human) - GPR31 gene High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (PubMed:21712392, PubMed:29227475). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes (PubMed:26965684, PubMed:28619714, PubMed:29227475). 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways leading to cell growth (PubMed:21712392, PubMed:29227475). Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (PubMed:28619714). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens (By similarity). Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury (PubMed:29227475). Indicus|evm.model.CM009499.1.578 Q569L8 CENPJ_MOUSE 59.055 0.261506 0.355655 Cenpj - Centromere protein J - Mus musculus (Mouse) - Cenpj gene Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (By similarity). Indicus|evm.model.CM009499.1.579 Q9BWV7 TTLL2_HUMAN 70.058 0.977316 0.893581 TTLL2 - Probable tubulin polyglutamylase TTLL2 - Homo sapiens (Human) - TTLL2 gene Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity). Indicus|evm.model.CM009499.1.580 A2VE54 UN93A_BOVIN 78.337 0.994778 0.838074 UNC93A - Protein unc-93 homolog A - Bos taurus (Bovine) - UNC93A gene Indicus|evm.model.CM009499.1.586 P55196 AFAD_HUMAN 88.830 0.750579 0.947368 AFDN - Afadin - Homo sapiens (Human) - AFDN gene Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). Indicus|evm.model.CM009499.1.587 Q4R918 KIF25_MACFA 59.484 0.867955 1.05973 KIF25 - Kinesin-like protein KIF25 - Macaca fascicularis (Crab-eating macaque) - KIF25 gene Minus-end microtubule-dependent motor protein (PubMed:28263957). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (By similarity). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (By similarity). May also act as a negative regulator of amino acid starvation-induced autophagy (By similarity). Indicus|evm.model.CM009499.1.588 Q8N878 FRMD1_HUMAN 54.444 0.996176 0.952641 FRMD1 - FERM domain-containing protein 1 - Homo sapiens (Human) - FRMD1 gene cytoplasmic side of apical plasma membrane, activating transcription factor binding, positive regulation of hippo signaling Indicus|evm.model.CM009499.1.593 Q8R4A3 DACT1_MOUSE 75.000 0.0531915 0.845758 Dact1 - Dapper homolog 1 - Mus musculus (Mouse) - Dact1 gene Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB (By similarity). Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway. The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling (By similarity). May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. Indicus|evm.model.CM009499.1.596 Q9H3U7 SMOC2_HUMAN 93.062 0.902386 1.03363 SMOC2 - SPARC-related modular calcium-binding protein 2 precursor - Homo sapiens (Human) - SMOC2 gene Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis. Indicus|evm.model.CM009499.1.602 Q95116 TSP2_BOVIN 99.572 0.979027 1.0188 THBS2 - Thrombospondin-2 precursor - Bos taurus (Bovine) - THBS2 gene Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties (By similarity). Indicus|evm.model.CM009499.1.604 A2RRH5 WDR27_HUMAN 64.734 0.997462 0.952842 WDR27 - WD repeat-containing protein 27 - Homo sapiens (Human) - WDR27 gene nucleoplasm Indicus|evm.model.CM009499.1.605 A2VDZ5 CF120_BOVIN 98.913 0.989189 1.00543 UPF0669 protein C6orf120 homolog precursor - Bos taurus (Bovine) Indicus|evm.model.CM009499.1.606 Q2T9V9 PHF10_BOVIN 99.756 0.904867 1.10244 PHF10 - PHD finger protein 10 - Bos taurus (Bovine) - PHF10 gene Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Indicus|evm.model.CM009499.1.607 Q8IZS6 DYLT2_HUMAN 87.374 0.989744 0.984848 DYNLT2 - Dynein light chain Tctex-type protein 2 - Homo sapiens (Human) - DYNLT2 gene May be an accessory component of axonemal dynein and cytoplasmic dynein 1 (PubMed:11278908, PubMed:12584439). Candidate for involvement in male sterility (By similarity). Indicus|evm.model.CM009499.1.608 Q5T6L9 EMARD_HUMAN 73.560 0.964337 1.03392 ERMARD - Endoplasmic reticulum membrane-associated RNA degradation protein - Homo sapiens (Human) - ERMARD gene May play a role in neuronal migration during embryonic development. Indicus|evm.model.CM009499.1.613 P30205 WC11_BOVIN 88.506 0.152753 0.392061 Antigen WC1.1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009499.1.614 O00548 DLL1_HUMAN 89.227 0.997234 1 DLL1 - Delta-like protein 1 precursor - Homo sapiens (Human) - DLL1 gene Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B-cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (PubMed:11581320). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity). Indicus|evm.model.CM009499.1.616 A6QNT4 F120B_BOVIN 95.622 0.997268 1.04571 FAM120B - Constitutive coactivator of peroxisome proliferator-activated receptor gamma - Bos taurus (Bovine) - FAM120B gene Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity). Indicus|evm.model.CM009499.1.617 Q2TBX6 PSB1_BOVIN 99.585 0.991736 1.00415 PSMB1 - Proteasome subunit beta type-1 precursor - Bos taurus (Bovine) - PSMB1 gene Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Indicus|evm.model.CM009499.1.618 Q2HJ52 TBP_BOVIN 99.315 0.986301 0.45768 TBP - TATA-box-binding protein - Bos taurus (Bovine) - TBP gene General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Indicus|evm.model.CM009499.1.619 P20226 TBP_HUMAN 99.324 0.636364 0.681416 TBP - TATA-box-binding protein - Homo sapiens (Human) - TBP gene General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Indicus|evm.model.CM009499.1.620 Q2YDC9 PDCD2_BOVIN 99.709 0.994203 1.00291 PDCD2 - Programmed cell death protein 2 - Bos taurus (Bovine) - PDCD2 gene May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation (By similarity). Indicus|evm.model.CM009500.1.3 Q9BQI4 CCDC3_HUMAN 50.820 0.993464 0.566667 CCDC3 - Coiled-coil domain-containing protein 3 precursor - Homo sapiens (Human) - CCDC3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity). Indicus|evm.model.CM009500.1.4 Q13136 LIPA1_HUMAN 70.777 0.808824 0.339434 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009500.1.5 Q13136 LIPA1_HUMAN 65.291 0.94621 0.340266 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009500.1.6 Q32L86 T126A_BOVIN 97.170 0.287671 1.85279 TMEM126A - Transmembrane protein 126A - Bos taurus (Bovine) - TMEM126A gene mitochondrion, mitochondrial respiratory chain complex I assembly Indicus|evm.model.CM009500.1.7 P23508 CRCM_HUMAN 96.794 0.86262 1.13269 MCC - Colorectal mutant cancer protein - Homo sapiens (Human) - MCC gene Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). Indicus|evm.model.CM009500.1.8 Q8IU60 DCP2_HUMAN 91.294 0.844622 1.19524 DCP2 - m7GpppN-mRNA hydrolase - Homo sapiens (Human) - DCP2 gene Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968, PubMed:28002401). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). Indicus|evm.model.CM009500.1.9 Q29RM3 REEP5_BOVIN 98.000 0.846154 0.619048 REEP5 - Receptor expression-enhancing protein 5 - Bos taurus (Bovine) - REEP5 gene May enhance the cell surface expression of odorant receptors. Indicus|evm.model.CM009500.1.10 Q3ZBG7 SRP19_BOVIN 100.000 0.986207 1.00694 SRP19 - Signal recognition particle 19 kDa protein - Bos taurus (Bovine) - SRP19 gene Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. Indicus|evm.model.CM009500.1.11 P25054 APC_HUMAN 94.563 0.999299 1.00317 APC - Adenomatous polyposis coli protein - Homo sapiens (Human) - APC gene Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. Indicus|evm.model.CM009500.1.13 Q9HCS5 E41LA_HUMAN 94.898 0.997089 1.00146 EPB41L4A - Band 4.1-like protein 4A - Homo sapiens (Human) - EPB41L4A gene cytoskeleton, actomyosin structure organization Indicus|evm.model.CM009500.1.15 O75323 NIPS2_HUMAN 88.182 0.801471 0.475524 NIPSNAP2 - Protein NipSnap homolog 2 - Homo sapiens (Human) - NIPSNAP2 gene May act as a positive regulator of L-type calcium channels. Indicus|evm.model.CM009500.1.16 Q5NVD3 NREP_PONAB 82.353 0.736264 1.33824 NREP - Neuronal regeneration-related protein - Pongo abelii (Sumatran orangutan) - NREP gene May have roles in neural function and cellular differentiation. Ectopic expression promotes axonal regeneration, induces differentiation of fibroblast into myofibroblast, induces myofibroblast ameboid migration, augments motility of gliomas, and increases retinoic-acid regulation of lipid-droplet biogenesis. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation. Indicus|evm.model.CM009500.1.17 Q5R746 YTDC2_PONAB 96.993 0.998601 1 YTHDC2 - 3'-5' RNA helicase YTHDC2 - Pongo abelii (Sumatran orangutan) - YTHDC2 gene 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis. Indicus|evm.model.CM009500.1.19 Q8WVD3 RN138_HUMAN 58.772 0.980769 0.42449 RNF138 - E3 ubiquitin-protein ligase RNF138 - Homo sapiens (Human) - RNF138 gene E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285). Indicus|evm.model.CM009500.1.20 P70604 KCNN2_RAT 94.000 0.420382 0.812069 Kcnn2 - Small conductance calcium-activated potassium channel protein 2 - Rattus norvegicus (Rat) - Kcnn2 gene Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Indicus|evm.model.CM009500.1.21 P70604 KCNN2_RAT 97.551 0.724036 0.581034 Kcnn2 - Small conductance calcium-activated potassium channel protein 2 - Rattus norvegicus (Rat) - Kcnn2 gene Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Indicus|evm.model.CM009500.1.22 P82916 RT17_BOVIN 99.231 0.984733 1.00769 MRPS17 - 28S ribosomal protein S17, mitochondrial - Bos taurus (Bovine) - MRPS17 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit Indicus|evm.model.CM009500.1.23 P62828 RAN_RAT 70.968 0.8 0.532407 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Indicus|evm.model.CM009500.1.24 Q2KIS1 RENBP_BOVIN 79.592 0.510638 0.217593 RENBP - N-acylglucosamine 2-epimerase - Bos taurus (Bovine) - RENBP gene Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). Indicus|evm.model.CM009500.1.25 Q9NQ86 TRI36_HUMAN 94.787 0.99726 1.00275 TRIM36 - E3 ubiquitin-protein ligase TRIM36 - Homo sapiens (Human) - TRIM36 gene E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. Indicus|evm.model.CM009500.1.26 Q5EAD5 PGTB1_BOVIN 91.429 0.994819 1.02387 PGGT1B - Geranylgeranyl transferase type-1 subunit beta - Bos taurus (Bovine) - PGGT1B gene Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity). Indicus|evm.model.CM009500.1.27 Q8NEF3 CC112_HUMAN 90.724 0.839695 1.17489 CCDC112 - Coiled-coil domain-containing protein 112 - Homo sapiens (Human) - CCDC112 gene Indicus|evm.model.CM009500.1.29 A7MB89 FEM1C_BOVIN 100.000 0.996764 1.00162 FEM1C - Protein fem-1 homolog C - Bos taurus (Bovine) - FEM1C gene Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Indicus|evm.model.CM009500.1.30 Q9Y2D4 EXC6B_HUMAN 77.966 0.445629 0.578298 EXOC6B - Exocyst complex component 6B - Homo sapiens (Human) - EXOC6B gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Indicus|evm.model.CM009500.1.31 Q2LGB7 TCAM2_BOVIN 100.000 0.991416 1.00431 TICAM2 - TIR domain-containing adapter molecule 2 - Bos taurus (Bovine) - TICAM2 gene Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria. Indicus|evm.model.CM009500.1.33 Q9Y3B3 TMED7_HUMAN 96.444 0.99115 1.00893 TMED7 - Transmembrane emp24 domain-containing protein 7 precursor - Homo sapiens (Human) - TMED7 gene Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications. Indicus|evm.model.CM009500.1.34 Q3SZU4 CDO1_BOVIN 100.000 0.984496 0.645 CDO1 - Cysteine dioxygenase type 1 - Bos taurus (Bovine) - CDO1 gene cysteine dioxygenase activity, ferrous iron binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, L-cysteine catabolic process Indicus|evm.model.CM009500.1.35 Q3SZU4 CDO1_BOVIN 98.246 0.736842 0.38 CDO1 - Cysteine dioxygenase type 1 - Bos taurus (Bovine) - CDO1 gene cysteine dioxygenase activity, ferrous iron binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, L-cysteine catabolic process Indicus|evm.model.CM009500.1.36 Q9DCR2 AP3S1_MOUSE 100.000 0.801587 0.65285 Ap3s1 - AP-3 complex subunit sigma-1 - Mus musculus (Mouse) - Ap3s1 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Indicus|evm.model.CM009500.1.37 A0A6J2ATK2 AMPQ_ACIJB 77.117 0.99787 0.946573 LVRN - Aminopeptidase Q - Acinonyx jubatus (Cheetah) - LVRN gene Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface (By similarity). Involved in coat pigmentation patterns. During skin development, may be required to establish the periodicity of tabby markings, initiating a pre-pattern at or before hair follicle development (PubMed:22997338). Indicus|evm.model.CM009500.1.38 Q3UKZ7 A14EL_MOUSE 84.211 0.986842 1 Arl14epl - ARL14 effector protein-like - Mus musculus (Mouse) - Arl14epl gene Indicus|evm.model.CM009500.1.40 Q3T044 P33MX_BOVIN 100.000 0.993464 1.00328 P33MONOX - Putative monooxygenase p33MONOX - Bos taurus (Bovine) - P33MONOX gene Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth (By similarity). Indicus|evm.model.CM009500.1.41 F1LWT0 SIMC1_RAT 74.811 0.656762 0.770932 Simc1 - SUMO-interacting motif-containing protein 1 - Rattus norvegicus (Rat) - Simc1 gene Inhibits the protease activity of CAPN3. Indicus|evm.model.CM009500.1.42 Q5RDY9 F151A_PONAB 75.000 0.614583 0.164103 FAM151A - Protein FAM151A - Pongo abelii (Sumatran orangutan) - FAM151A gene Indicus|evm.model.CM009500.1.43 Q8WW52 F151A_HUMAN 68.908 0.95935 0.210256 FAM151A - Protein FAM151A - Homo sapiens (Human) - FAM151A gene extracellular exosome, membrane Indicus|evm.model.CM009500.1.44 Q8WW52 F151A_HUMAN 57.273 0.989529 0.326496 FAM151A - Protein FAM151A - Homo sapiens (Human) - FAM151A gene extracellular exosome, membrane Indicus|evm.model.CM009500.1.45 Q29RH4 THOC3_BOVIN 82.022 0.994152 0.974359 THOC3 - THO complex subunit 3 - Bos taurus (Bovine) - THOC3 gene Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity). Indicus|evm.model.CM009500.1.46 P84087 CPLX2_RAT 100.000 0.985185 1.00746 Cplx2 - Complexin-2 - Rattus norvegicus (Rat) - Cplx2 gene Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (PubMed:15870114). Indicus|evm.model.CM009500.1.47 P17124 HRH2_CANLF 82.730 0.994444 1.00279 HRH2 - Histamine H2 receptor - Canis lupus familiaris (Dog) - HRH2 gene The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Indicus|evm.model.CM009500.1.49 Q5E9M8 SFXN1_BOVIN 100.000 0.993808 1.00311 SFXN1 - Sideroflexin-1 - Bos taurus (Bovine) - SFXN1 gene Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D-serine and L-serine. Also able to transport other amino-acids, such as alanine (By similarity). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity). Indicus|evm.model.CM009500.1.50 Q95136 DRD1_BOVIN 100.000 0.995526 1.00224 DRD1 - D(1A) dopamine receptor - Bos taurus (Bovine) - DRD1 gene Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Indicus|evm.model.CM009500.1.52 Q9P109 GCNT4_HUMAN 87.665 0.995604 1.00442 GCNT4 - Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 - Homo sapiens (Human) - GCNT4 gene Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity. Indicus|evm.model.CM009500.1.53 Q8N7Z5 ANR31_HUMAN 63.051 0.9637 1.07368 ANKRD31 - Ankyrin repeat domain-containing protein 31 - Homo sapiens (Human) - ANKRD31 gene Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes. Indicus|evm.model.CM009500.1.54 A7Z064 HMDH_BOVIN 100.000 0.99775 1.00113 HMGCR - 3-hydroxy-3-methylglutaryl-coenzyme A reductase - Bos taurus (Bovine) - HMGCR gene Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. Indicus|evm.model.CM009500.1.55 Q9GKI7 CERT_BOVIN 100.000 0.9968 1.0016 CERT1 - Ceramide transfer protein - Bos taurus (Bovine) - CERT1 gene Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. Indicus|evm.model.CM009500.1.56 Q9UBT6 POLK_HUMAN 83.486 0.98861 1.0092 POLK - DNA polymerase kappa - Homo sapiens (Human) - POLK gene DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Indicus|evm.model.CM009500.1.58 Q8NA72 POC5_HUMAN 79.690 0.996534 1.00348 POC5 - Centrosomal protein POC5 - Homo sapiens (Human) - POC5 gene Essential for the assembly of the distal half of centrioles, required for centriole elongation. Indicus|evm.model.CM009500.1.59 Q496J9 SV2C_HUMAN 97.078 0.7675 0.550206 SV2C - Synaptic vesicle glycoprotein 2C - Homo sapiens (Human) - SV2C gene Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. Indicus|evm.model.CM009500.1.60 Q69ZS6 SV2C_MOUSE 89.598 0.972222 0.594223 Sv2c - Synaptic vesicle glycoprotein 2C - Mus musculus (Mouse) - Sv2c gene Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. Indicus|evm.model.CM009500.1.61 Q13576 IQGA2_HUMAN 89.587 0.998731 1.00063 IQGAP2 - Ras GTPase-activating-like protein IQGAP2 - Homo sapiens (Human) - IQGAP2 gene Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Indicus|evm.model.CM009500.1.62 A7YY44 PAR1_BOVIN 98.025 0.930876 1.01639 F2R - Proteinase-activated receptor 1 precursor - Bos taurus (Bovine) - F2R gene High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. Indicus|evm.model.CM009500.1.63 Q2HJA4 PAR2_BOVIN 100.000 0.994949 1.00253 F2RL1 - Proteinase-activated receptor 2 precursor - Bos taurus (Bovine) - F2RL1 gene Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Indicus|evm.model.CM009500.1.64 Q8WXG8 S100Z_HUMAN 85.859 0.98 1.0101 S100Z - Protein S100-Z - Homo sapiens (Human) - S100Z gene calcium ion binding, calcium-dependent protein binding, protein homodimerization activity Indicus|evm.model.CM009500.1.65 Q28557 CRHBP_SHEEP 96.296 0.993846 1.00309 CRHBP - Corticotropin-releasing factor-binding protein precursor - Ovis aries (Sheep) - CRHBP gene Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Indicus|evm.model.CM009500.1.66 Q8N302 AGGF1_HUMAN 88.167 0.967742 0.998599 AGGF1 - Angiogenic factor with G patch and FHA domains 1 - Homo sapiens (Human) - AGGF1 gene Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. Indicus|evm.model.CM009500.1.69 O95263 PDE8B_HUMAN 90.539 0.997211 0.810169 PDE8B - High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B - Homo sapiens (Human) - PDE8B gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. Indicus|evm.model.CM009500.1.70 Q9HAD4 WDR41_HUMAN 76.688 0.994937 0.860566 WDR41 - WD repeat-containing protein 41 - Homo sapiens (Human) - WDR41 gene Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292). Indicus|evm.model.CM009500.1.71 O09113 OTP_MOUSE 97.802 0.48913 0.566154 Otp - Homeobox protein orthopedia - Mus musculus (Mouse) - Otp gene Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. Indicus|evm.model.CM009500.1.72 O09113 OTP_MOUSE 100.000 0.609053 0.747692 Otp - Homeobox protein orthopedia - Mus musculus (Mouse) - Otp gene Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. Indicus|evm.model.CM009500.1.73 P48427 TBCA_BOVIN 100.000 0.981651 1.00926 TBCA - Tubulin-specific chaperone A - Bos taurus (Bovine) - TBCA gene Tubulin-folding protein; involved in the early step of the tubulin folding pathway. Indicus|evm.model.CM009500.1.74 P54252 ATX3_HUMAN 97.814 0.98913 0.509695 ATXN3 - Ataxin-3 - Homo sapiens (Human) - ATXN3 gene Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). Indicus|evm.model.CM009500.1.76 Q32PG1 AP3B1_BOVIN 99.815 0.998157 1.00092 AP3B1 - AP-3 complex subunit beta-1 - Bos taurus (Bovine) - AP3B1 gene Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Indicus|evm.model.CM009500.1.77 O77735 SCAM1_PIG 84.179 0.931148 0.902367 SCAMP1 - Secretory carrier-associated membrane protein 1 - Sus scrofa (Pig) - SCAMP1 gene Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. Indicus|evm.model.CM009500.1.78 Q6ZUX7 LHPL2_HUMAN 93.860 0.991266 1.00439 LHFPL2 - LHFPL tetraspan subfamily member 2 protein - Homo sapiens (Human) - LHFPL2 gene Plays a role in female and male fertility. Involved in distal reproductive tract development. Indicus|evm.model.CM009500.1.79 P15848 ARSB_HUMAN 89.306 0.996255 1.00188 ARSB - Arylsulfatase B precursor - Homo sapiens (Human) - ARSB gene Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Indicus|evm.model.CM009500.1.80 Q9UI17 M2GD_HUMAN 93.064 0.99654 1.00115 DMGDH - Dimethylglycine dehydrogenase, mitochondrial precursor - Homo sapiens (Human) - DMGDH gene Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro. Indicus|evm.model.CM009500.1.81 Q9H2M3 BHMT2_HUMAN 78.571 0.753488 1.18457 BHMT2 - S-methylmethionine--homocysteine S-methyltransferase BHMT2 - Homo sapiens (Human) - BHMT2 gene Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. Indicus|evm.model.CM009500.1.82 Q5I597 BHMT1_BOVIN 100.000 0.995098 1.00246 BHMT - Betaine--homocysteine S-methyltransferase 1 - Bos taurus (Bovine) - BHMT gene Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). Indicus|evm.model.CM009500.1.83 Q8N9B5 JMY_HUMAN 87.500 0.997984 1.00405 JMY - Junction-mediating and -regulatory protein - Homo sapiens (Human) - JMY gene Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). Indicus|evm.model.CM009500.1.84 Q2KJ56 HOME1_BOVIN 100.000 0.9 1.10169 HOMER1 - Homer protein homolog 1 - Bos taurus (Bovine) - HOMER1 gene Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity). Indicus|evm.model.CM009500.1.85 Q2HJ44 GLD2_BOVIN 99.793 0.995876 1.00207 TENT2 - Poly(A) RNA polymerase GLD2 - Bos taurus (Bovine) - TENT2 gene Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs. Indicus|evm.model.CM009500.1.86 Q8N3K9 CMYA5_HUMAN 81.785 0.345951 0.980339 CMYA5 - Cardiomyopathy-associated protein 5 - Homo sapiens (Human) - CMYA5 gene May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). Indicus|evm.model.CM009500.1.87 Q5HYI7 MTX3_HUMAN 94.551 0.99361 1.00321 MTX3 - Metaxin-3 - Homo sapiens (Human) - MTX3 gene Could function in transport of proteins into the mitochondrion. Indicus|evm.model.CM009500.1.88 Q3SWW8 TSP4_BOVIN 99.896 0.997921 1.00104 THBS4 - Thrombospondin-4 precursor - Bos taurus (Bovine) - THBS4 gene Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity). Indicus|evm.model.CM009500.1.89 Q4R6L9 SERC5_MACFA 86.557 0.919565 1.08491 SERINC5 - Serine incorporator 5 - Macaca fascicularis (Crab-eating macaque) - SERINC5 gene Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). Indicus|evm.model.CM009500.1.90 Q5RAL9 GNA1_PONAB 99.457 0.989189 1.00543 GNPNAT1 - Glucosamine 6-phosphate N-acetyltransferase - Pongo abelii (Sumatran orangutan) - GNPNAT1 gene Indicus|evm.model.CM009500.1.91 Q5RDP3 STYX_PONAB 97.758 0.991071 1.00448 STYX - Serine/threonine/tyrosine-interacting protein - Pongo abelii (Sumatran orangutan) - STYX gene Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (By similarity). Plays a role in spermatogenesis (By similarity). Indicus|evm.model.CM009500.1.92 P62334 PRS10_MOUSE 100.000 0.960396 1.03856 Psmc6 - 26S proteasome regulatory subunit 10B - Mus musculus (Mouse) - Psmc6 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Indicus|evm.model.CM009500.1.93 A5PJN2 ERO1A_BOVIN 100.000 0.995736 1.00214 ERO1A - ERO1-like protein alpha precursor - Bos taurus (Bovine) - ERO1A gene Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1 (By similarity). Indicus|evm.model.CM009500.1.94 Q8N3F9 G137C_HUMAN 94.326 0.498221 0.655012 GPR137C - Integral membrane protein GPR137C - Homo sapiens (Human) - GPR137C gene Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. Indicus|evm.model.CM009500.1.95 Q9P2K2 TXD16_HUMAN 74.694 0.993703 0.962424 TXNDC16 - Thioredoxin domain-containing protein 16 precursor - Homo sapiens (Human) - TXNDC16 gene endoplasmic reticulum lumen, extracellular exosome Indicus|evm.model.CM009500.1.96 P43116 PE2R2_HUMAN 83.520 0.994334 0.986034 PTGER2 - Prostaglandin E2 receptor EP2 subtype - Homo sapiens (Human) - PTGER2 gene Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. Indicus|evm.model.CM009500.1.97 Q8MJJ1 SPG21_BOVIN 100.000 0.993528 1.00325 SPG21 - Maspardin - Bos taurus (Bovine) - SPG21 gene May play a role as a negative regulatory factor in CD4-dependent T-cell activation. Indicus|evm.model.CM009500.1.98 O77480 FMT_BOVIN 99.744 0.994885 1.00256 MTFMT - Methionyl-tRNA formyltransferase, mitochondrial precursor - Bos taurus (Bovine) - MTFMT gene Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism. Indicus|evm.model.CM009500.1.99 A0JNM1 OSTB_BOVIN 100.000 0.984733 1.00769 SLC51B - Organic solute transporter subunit beta - Bos taurus (Bovine) - SLC51B gene Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities (By similarity). Indicus|evm.model.CM009500.1.100 Q08E00 RASLC_BOVIN 99.248 0.992509 1.00376 RASL12 - Ras-like protein family member 12 - Bos taurus (Bovine) - RASL12 gene plasma membrane, GDP binding, GTP binding, GTPase activity Indicus|evm.model.CM009500.1.101 C9JR72 KBTBD_HUMAN 89.738 0.995643 1.00218 KBTBD13 - Kelch repeat and BTB domain-containing protein 13 - Homo sapiens (Human) - KBTBD13 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. Indicus|evm.model.CM009500.1.102 F5GYI3 UBA1L_HUMAN 72.263 0.99511 1.07349 UBAP1L - Ubiquitin-associated protein 1-like - Homo sapiens (Human) - UBAP1L gene ESCRT I complex, ubiquitin binding, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Indicus|evm.model.CM009500.1.103 Q9WTY1 PDCD7_MOUSE 86.644 0.769841 0.784232 Pdcd7 - Programmed cell death protein 7 - Mus musculus (Mouse) - Pdcd7 gene Promotes apoptosis when overexpressed. Indicus|evm.model.CM009500.1.104 Q5R7N3 CLPX_PONAB 98.353 0.340449 2.81201 CLPX - ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - CLPX gene ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure. ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis. Indicus|evm.model.CM009500.1.105 Q8N5Y8 PAR16_HUMAN 92.857 0.993808 1.00311 PARP16 - Protein mono-ADP-ribosyltransferase PARP16 - Homo sapiens (Human) - PARP16 gene Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565). Indicus|evm.model.CM009500.1.106 Q8IVU1 IGDC3_HUMAN 84.211 0.897695 0.85258 IGDCC3 - Immunoglobulin superfamily DCC subclass member 3 precursor - Homo sapiens (Human) - IGDCC3 gene Indicus|evm.model.CM009500.1.107 Q8TDY8 IGDC4_HUMAN 89.023 0.997579 0.9912 IGDCC4 - Immunoglobulin superfamily DCC subclass member 4 precursor - Homo sapiens (Human) - IGDCC4 gene Indicus|evm.model.CM009500.1.108 Q6V1X1 DPP8_HUMAN 98.107 0.997775 1.00111 DPP8 - Dipeptidyl peptidase 8 - Homo sapiens (Human) - DPP8 gene Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396) (Probable). Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:29967349, PubMed:32796818). Indicus|evm.model.CM009500.1.109 A7YY55 HACD3_BOVIN 100.000 0.99449 1.00276 HACD3 - Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 - Bos taurus (Bovine) - HACD3 gene Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity). Indicus|evm.model.CM009500.1.110 Q5EA76 INT14_BOVIN 100.000 0.996146 1.00193 INTS14 - Integrator complex subunit 14 - Bos taurus (Bovine) - INTS14 gene Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Indicus|evm.model.CM009500.1.111 Q28139 NCKX1_BOVIN 99.507 0.998357 1.00082 SLC24A1 - Sodium/potassium/calcium exchanger 1 - Bos taurus (Bovine) - SLC24A1 gene Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity). Indicus|evm.model.CM009500.1.112 Q7Z401 MYCPP_HUMAN 91.252 0.998952 1.02415 DENND4A - C-myc promoter-binding protein - Homo sapiens (Human) - DENND4A gene Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. Indicus|evm.model.CM009500.1.114 P62494 RB11A_RAT 100.000 0.990783 1.00463 Rab11a - Ras-related protein Rab-11A precursor - Rattus norvegicus (Rat) - Rab11a gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:11163216). Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Indicus|evm.model.CM009500.1.115 Q80T91 MEG11_MOUSE 80.753 0.912377 0.836847 Megf11 - Multiple epidermal growth factor-like domains protein 11 precursor - Mus musculus (Mouse) - Megf11 gene May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. Indicus|evm.model.CM009500.1.116 A6BM72 MEG11_HUMAN 85.185 0.672956 0.152299 MEGF11 - Multiple epidermal growth factor-like domains protein 11 precursor - Homo sapiens (Human) - MEGF11 gene May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity). Indicus|evm.model.CM009500.1.117 A0JN80 DI3L1_BOVIN 99.905 0.998102 1.00095 DIS3L - DIS3-like exonuclease 1 - Bos taurus (Bovine) - DIS3L gene Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. Indicus|evm.model.CM009500.1.118 Q3ZCC4 TIPIN_BOVIN 100.000 0.83046 1.2 TIPIN - TIMELESS-interacting protein - Bos taurus (Bovine) - TIPIN gene Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (By similarity). Indicus|evm.model.CM009500.1.119 Q02750 MP2K1_HUMAN 100.000 0.994924 1.00254 MAP2K1 - Dual specificity mitogen-activated protein kinase kinase 1 - Homo sapiens (Human) - MAP2K1 gene Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. Indicus|evm.model.CM009500.1.120 Q29S17 SNPC5_BOVIN 100.000 0.979798 1.0102 SNAPC5 - snRNA-activating protein complex subunit 5 - Bos taurus (Bovine) - SNAPC5 gene Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). Indicus|evm.model.CM009500.1.121 Q58DW0 RL4_BOVIN 100.000 0.995272 1.00237 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Indicus|evm.model.CM009500.1.122 A6QM04 ZWILC_BOVIN 100.000 0.99661 1.0017 ZWILCH - Protein zwilch homolog - Bos taurus (Bovine) - ZWILCH gene Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity). Indicus|evm.model.CM009500.1.123 Q6UWM7 LCTL_HUMAN 87.125 0.996479 1.00176 LCTL - Lactase-like protein precursor - Homo sapiens (Human) - LCTL gene Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Indicus|evm.model.CM009500.1.125 O43541 SMAD6_HUMAN 95.573 0.995984 1.00403 SMAD6 - Mothers against decapentaplegic homolog 6 - Homo sapiens (Human) - SMAD6 gene Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta (PubMed:9436979, PubMed:16951688, PubMed:22275001, PubMed:9759503, PubMed:10647776, PubMed:10708948, PubMed:10708949, PubMed:30848080). Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes (PubMed:16951688). Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (PubMed:9436979, PubMed:30848080). Binds to regulatory elements in target promoter regions (PubMed:16491121). Indicus|evm.model.CM009500.1.126 P84025 SMAD3_RAT 99.765 0.995305 1.00235 Smad3 - Mothers against decapentaplegic homolog 3 - Rattus norvegicus (Rat) - Smad3 gene Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). Indicus|evm.model.CM009500.1.128 Q5RET3 AAGAB_PONAB 90.794 0.993671 1.00317 AAGAB - Alpha- and gamma-adaptin-binding protein p34 - Pongo abelii (Sumatran orangutan) - AAGAB gene May be involved in endocytic recycling of growth factor receptors such as EGFR. Indicus|evm.model.CM009500.1.129 Q86VS3 IQCH_HUMAN 76.348 0.997164 1.03019 IQCH - IQ domain-containing protein H - Homo sapiens (Human) - IQCH gene May play a regulatory role in spermatogenesis. Indicus|evm.model.CM009500.1.130 Q0VG49 CO061_MOUSE 94.904 0.987342 1.00637 Uncharacterized protein C15orf61 homolog precursor - Mus musculus (Mouse) Indicus|evm.model.CM009500.1.131 Q62862 MP2K5_RAT 85.855 0.992424 0.589286 Map2k5 - Dual specificity mitogen-activated protein kinase kinase 5 - Rattus norvegicus (Rat) - Map2k5 gene Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). Indicus|evm.model.CM009500.1.132 Q8BX46 SKOR1_MOUSE 92.374 0.98617 0.975104 Skor1 - SKI family transcriptional corepressor 1 - Mus musculus (Mouse) - Skor1 gene Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1. Indicus|evm.model.CM009500.1.133 A8D8X1 RL10_SHEEP 68.627 0.737226 0.640187 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009500.1.134 O75925 PIAS1_HUMAN 99.078 0.996933 1.00154 PIAS1 - E3 SUMO-protein ligase PIAS1 - Homo sapiens (Human) - PIAS1 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Indicus|evm.model.CM009500.1.135 Q3T0E8 CALL4_BOVIN 98.693 0.883721 1.12418 CALML4 - Calmodulin-like protein 4 - Bos taurus (Bovine) - CALML4 gene calcium ion binding, enzyme regulator activity Indicus|evm.model.CM009500.1.136 Q5JZQ8 CLN6_CANLF 93.891 0.990385 1 CLN6 - Ceroid-lipofuscinosis neuronal protein 6 homolog - Canis lupus familiaris (Dog) - CLN6 gene early endosome, endoplasmic reticulum, endoplasmic reticulum lumen, membrane raft, lysophosphatidic acid binding, protein homodimerization activity, sulfatide binding, cholesterol metabolic process, ganglioside metabolic process, glycosaminoglycan metabolic process Indicus|evm.model.CM009500.1.138 Q9UK73 FEM1B_HUMAN 99.522 0.996815 1.00159 FEM1B - Protein fem-1 homolog B - Homo sapiens (Human) - FEM1B gene Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. Indicus|evm.model.CM009500.1.139 Q9UKX5 ITA11_HUMAN 92.741 0.979079 1.00589 ITGA11 - Integrin alpha-11 precursor - Homo sapiens (Human) - ITGA11 gene Integrin alpha-11/beta-1 is a receptor for collagen. Indicus|evm.model.CM009500.1.141 Q9UQ03 COR2B_HUMAN 98.627 0.929638 0.977083 CORO2B - Coronin-2B - Homo sapiens (Human) - CORO2B gene May play a role in the reorganization of neuronal actin structure. Indicus|evm.model.CM009500.1.142 P51122 AN32A_BOVIN 100.000 0.992 1.00402 ANP32A - Acidic leucine-rich nuclear phosphoprotein 32 family member A - Bos taurus (Bovine) - ANP32A gene Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A. Indicus|evm.model.CM009500.1.143 Q32KL7 SPESP_BOVIN 99.185 0.986559 1.01639 SPESP1 - Sperm equatorial segment protein 1 precursor - Bos taurus (Bovine) - SPESP1 gene Involved in fertilization ability of sperm. Indicus|evm.model.CM009500.1.144 Q96PH1 NOX5_HUMAN 81.590 0.29602 1.05098 NOX5 - NADPH oxidase 5 - Homo sapiens (Human) - NOX5 gene Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. Indicus|evm.model.CM009500.1.145 O18756 GLCE_BOVIN 100.000 0.9625 1.03728 GLCE - D-glucuronyl C5-epimerase - Bos taurus (Bovine) - GLCE gene Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. Indicus|evm.model.CM009500.1.147 Q9NXK6 PAQR5_HUMAN 83.636 0.993958 1.00303 PAQR5 - Membrane progestin receptor gamma - Homo sapiens (Human) - PAQR5 gene Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). Indicus|evm.model.CM009500.1.148 Q02241 KIF23_HUMAN 93.222 0.996849 0.991667 KIF23 - Kinesin-like protein KIF23 - Homo sapiens (Human) - KIF23 gene Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. Indicus|evm.model.CM009500.1.149 P05386 RLA1_HUMAN 100.000 0.982609 1.00877 RPLP1 - 60S acidic ribosomal protein P1 - Homo sapiens (Human) - RPLP1 gene Plays an important role in the elongation step of protein synthesis. Indicus|evm.model.CM009500.1.151 Q04726 TLE3_HUMAN 99.093 0.997403 0.997409 TLE3 - Transducin-like enhancer protein 3 - Homo sapiens (Human) - TLE3 gene Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). Indicus|evm.model.CM009500.1.152 Q8HYY4 UACA_BOVIN 99.211 0.983769 1.01142 UACA - Uveal autoantigen with coiled-coil domains and ankyrin repeats protein - Bos taurus (Bovine) - UACA gene Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). Indicus|evm.model.CM009500.1.153 Q9BRS8 LARP6_HUMAN 92.774 0.977169 0.892057 LARP6 - La-related protein 6 - Homo sapiens (Human) - LARP6 gene Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. Indicus|evm.model.CM009500.1.154 Q5NVM3 THA10_PONAB 62.626 0.550562 0.674242 THAP10 - THAP domain-containing protein 10 - Pongo abelii (Sumatran orangutan) - THAP10 gene Indicus|evm.model.CM009500.1.155 Q8IUZ0 LRC49_HUMAN 87.313 0.888291 1.08309 LRRC49 - Leucine-rich repeat-containing protein 49 - Homo sapiens (Human) - LRRC49 gene cytoplasm, outer dynein arm assembly Indicus|evm.model.CM009500.1.156 Q6ZMP0 THSD4_HUMAN 89.868 0.98008 0.986248 THSD4 - Thrombospondin type-1 domain-containing protein 4 precursor - Homo sapiens (Human) - THSD4 gene Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity). Indicus|evm.model.CM009500.1.157 Q9TTF0 NR2E3_BOVIN 99.513 0.995146 1.00243 NR2E3 - Photoreceptor-specific nuclear receptor - Bos taurus (Bovine) - NR2E3 gene Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. Indicus|evm.model.CM009500.1.158 B2RTY4 MYO9A_HUMAN 89.963 0.115071 0.91405 MYO9A - Unconventional myosin-IXa - Homo sapiens (Human) - MYO9A gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). Indicus|evm.model.CM009500.1.159 Q96LD8 SENP8_HUMAN 90.995 0.985915 1.00472 SENP8 - Sentrin-specific protease 8 - Homo sapiens (Human) - SENP8 gene Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. Indicus|evm.model.CM009500.1.160 Q3V3G7 GRM2A_MOUSE 77.228 0.993333 0.9375 Gramd2a - GRAM domain-containing protein 2A - Mus musculus (Mouse) - Gramd2a gene Participates in the organization ofendoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). Indicus|evm.model.CM009500.1.162 P14618 KPYM_HUMAN 97.552 0.996241 1.00188 PKM - Pyruvate kinase PKM - Homo sapiens (Human) - PKM gene Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723). In addition to its role in glycolysis, also regulates transcription (PubMed:18191611, PubMed:21620138). Stimulates POU5F1-mediated transcriptional activation (PubMed:18191611). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). Also acts as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a general role in caspase independent cell death of tumor cells (PubMed:17308100). Indicus|evm.model.CM009500.1.163 Q2NL67 PARP6_HUMAN 92.691 0.891667 1.14286 PARP6 - Protein mono-ADP-ribosyltransferase PARP6 - Homo sapiens (Human) - PARP6 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Indicus|evm.model.CM009500.1.164 Q96J87 CELF6_HUMAN 98.129 0.995842 1 CELF6 - CUGBP Elav-like family member 6 - Homo sapiens (Human) - CELF6 gene RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA. Indicus|evm.model.CM009500.1.166 Q0V8R6 HEXA_BOVIN 100.000 0.996226 1.00189 HEXA - Beta-hexosaminidase subunit alpha precursor - Bos taurus (Bovine) - HEXA gene Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. Indicus|evm.model.CM009500.1.167 A6NGA9 TM202_HUMAN 69.076 0.921053 0.974359 TMEM202 - Transmembrane protein 202 - Homo sapiens (Human) - TMEM202 gene plasma membrane Indicus|evm.model.CM009500.1.168 A6NGA9 TM202_HUMAN 45.146 0.756554 0.978022 TMEM202 - Transmembrane protein 202 - Homo sapiens (Human) - TMEM202 gene plasma membrane Indicus|evm.model.CM009500.1.169 A2VEA3 ARI1_BOVIN 100.000 0.996403 1.0018 ARIH1 - E3 ubiquitin-protein ligase ARIH1 - Bos taurus (Bovine) - ARIH1 gene E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes. Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear. According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report EIF4E2 ubiquitination leads to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, may act in nuclear subcellular localization and nuclear morphology. Indicus|evm.model.CM009500.1.171 Q1JQ97 BBS4_BOVIN 100.000 0.996154 1.00193 BBS4 - Bardet-Biedl syndrome 4 protein homolog - Bos taurus (Bovine) - BBS4 gene May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane (By similarity). Indicus|evm.model.CM009500.1.172 A2VE47 ADPGK_BOVIN 100.000 0.995984 1.00201 ADPGK - ADP-dependent glucokinase precursor - Bos taurus (Bovine) - ADPGK gene Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity). Indicus|evm.model.CM009500.1.175 Q9JKA7 HCN4_RAT 95.553 0.720817 0.858097 Hcn4 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 - Rattus norvegicus (Rat) - Hcn4 gene Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih) (By similarity). May mediate responses to sour stimuli. Indicus|evm.model.CM009500.1.176 Q7Z4M0 RE114_HUMAN 73.864 0.984375 0.962406 REC114 - Meiotic recombination protein REC114 - Homo sapiens (Human) - REC114 gene Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Indicus|evm.model.CM009500.1.177 Q9Y639 NPTN_HUMAN 91.270 0.886926 0.711055 NPTN - Neuroplastin precursor - Homo sapiens (Human) - NPTN gene Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Indicus|evm.model.CM009500.1.178 Q5ZPR3 CD276_HUMAN 93.573 0.988764 1 CD276 - CD276 antigen precursor - Homo sapiens (Human) - CD276 gene May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. Indicus|evm.model.CM009500.1.179 A7YWL5 INSY1_BOVIN 99.315 0.993174 1.00342 INSYN1 - Inhibitory synaptic factor 1 - Bos taurus (Bovine) - INSYN1 gene Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. Indicus|evm.model.CM009500.1.180 Q8IYX1 TBC21_HUMAN 92.262 0.994065 1.00298 TBC1D21 - TBC1 domain family member 21 - Homo sapiens (Human) - TBC1D21 gene May act as a GTPase-activating protein for Rab family protein(s) (PubMed:19077034). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978). Indicus|evm.model.CM009500.1.182 Q17QH8 D39U1_BOVIN 99.660 0.99322 1.0034 SDR39U1 - Epimerase family protein SDR39U1 - Bos taurus (Bovine) - SDR39U1 gene Putative NADP-dependent oxidoreductase. Indicus|evm.model.CM009500.1.183 O15037 KHNYN_HUMAN 81.606 0.997046 0.998525 KHNYN - Protein KHNYN - Homo sapiens (Human) - KHNYN gene cytoplasmic ribonucleoprotein granule, nucleus, endoribonuclease activity, mRNA binding, RNA phosphodiester bond hydrolysis, endonucleolytic Indicus|evm.model.CM009500.1.184 Q17QF9 CBLN3_BOVIN 99.512 0.990291 1.00488 CBLN3 - Cerebellin-3 precursor - Bos taurus (Bovine) - CBLN3 gene May be involved in synaptic functions in the CNS. Indicus|evm.model.CM009500.1.185 Q9P2P1 NYNRI_HUMAN 82.382 0.986978 0.971022 NYNRIN - Protein NYNRIN - Homo sapiens (Human) - NYNRIN gene cytoplasmic ribonucleoprotein granule, nucleus, endoribonuclease activity, mRNA binding, RNA phosphodiester bond hydrolysis, endonucleolytic Indicus|evm.model.CM009500.1.186 Q14934 NFAC4_HUMAN 92.295 0.9728 0.692905 NFATC4 - Nuclear factor of activated T-cells, cytoplasmic 4 - Homo sapiens (Human) - NFATC4 gene Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:7749981, PubMed:11514544, PubMed:11997522, PubMed:17875713, PubMed:17213202, PubMed:18668201, PubMed:25663301). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:7749981, PubMed:18668201, PubMed:18347059). Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). Indicus|evm.model.CM009500.1.187 Q9Y572 RIPK3_HUMAN 63.566 0.99604 0.974903 RIPK3 - Receptor-interacting serine/threonine-protein kinase 3 - Homo sapiens (Human) - RIPK3 gene Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). Indicus|evm.model.CM009500.1.188 Q8NFM4 ADCY4_HUMAN 89.879 0.998075 0.964717 ADCY4 - Adenylate cyclase type 4 - Homo sapiens (Human) - ADCY4 gene Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Indicus|evm.model.CM009500.1.189 Q3T181 LT4R1_BOVIN 99.427 0.87 1.14613 LTB4R - Leukotriene B4 receptor 1 - Bos taurus (Bovine) - LTB4R gene Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response (By similarity). Indicus|evm.model.CM009500.1.190 Q9NPC1 LT4R2_HUMAN 81.513 0.991643 1.00279 LTB4R2 - Leukotriene B4 receptor 2 - Homo sapiens (Human) - LTB4R2 gene Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3. Indicus|evm.model.CM009500.1.191 Q3T191 CIDEB_BOVIN 99.543 0.990909 1.00457 CIDEB - Cell death activator CIDE-B - Bos taurus (Bovine) - CIDEB gene Activates apoptosis. Indicus|evm.model.CM009500.1.192 Q86U38 NOP9_HUMAN 88.522 0.99686 1.00157 NOP9 - Nucleolar protein 9 - Homo sapiens (Human) - NOP9 gene 90S preribosome, nucleolus, preribosome, small subunit precursor, RNA binding, endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit export from nucleus Indicus|evm.model.CM009500.1.193 Q96LJ7 DHRS1_HUMAN 85.304 0.99361 1 DHRS1 - Dehydrogenase/reductase SDR family member 1 - Homo sapiens (Human) - DHRS1 gene endoplasmic reticulum Indicus|evm.model.CM009500.1.194 Q5EA80 PGTA_BOVIN 100.000 0.996479 1.00176 RABGGTA - Geranylgeranyl transferase type-2 subunit alpha - Bos taurus (Bovine) - RABGGTA gene Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Indicus|evm.model.CM009500.1.195 Q9GLK0 TGM1_CANLF 88.690 0.985849 1.04049 TGM1 - Protein-glutamine gamma-glutamyltransferase K - Canis lupus familiaris (Dog) - TGM1 gene Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity). Indicus|evm.model.CM009500.1.196 Q9BSI4 TINF2_HUMAN 78.634 0.995575 1.00222 TINF2 - TERF1-interacting nuclear factor 2 - Homo sapiens (Human) - TINF2 gene Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. Indicus|evm.model.CM009500.1.197 Q32L93 GMPR2_BOVIN 100.000 0.440162 1.41667 GMPR2 - GMP reductase 2 - Bos taurus (Bovine) - GMPR2 gene Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity). Indicus|evm.model.CM009500.1.198 A2VDY3 CHM4A_BOVIN 100.000 0.991031 1.0045 CHMP4A - Charged multivesicular body protein 4a - Bos taurus (Bovine) - CHMP4A gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Indicus|evm.model.CM009500.1.199 Q9D411 TSSK4_MOUSE 86.826 0.993994 1.01524 Tssk4 - Testis-specific serine/threonine-protein kinase 4 - Mus musculus (Mouse) - Tssk4 gene Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (PubMed:17927909, PubMed:23599433, PubMed:23054012, PubMed:25361759, PubMed:26940607). May be involved in the Cre/Creb signaling pathway (PubMed:26940607). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro (PubMed:26940607). Phosphorylates ODF2 on 'Ser-95' (PubMed:26961893). Indicus|evm.model.CM009500.1.200 A4IFE9 TM9S1_BOVIN 99.835 0.996705 1.00165 TM9SF1 - Transmembrane 9 superfamily member 1 precursor - Bos taurus (Bovine) - TM9SF1 gene Plays an essential role in autophagy. Indicus|evm.model.CM009500.1.201 Q8TEX9 IPO4_HUMAN 90.657 0.998152 1.00093 IPO4 - Importin-4 - Homo sapiens (Human) - IPO4 gene Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Indicus|evm.model.CM009500.1.202 O95072 REC8_HUMAN 76.410 0.993103 1.06033 REC8 - Meiotic recombination protein REC8 homolog - Homo sapiens (Human) - REC8 gene Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). Indicus|evm.model.CM009500.1.203 Q96EP0 RNF31_HUMAN 88.363 0.704545 1.39552 RNF31 - E3 ubiquitin-protein ligase RNF31 - Homo sapiens (Human) - RNF31 gene E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). Indicus|evm.model.CM009500.1.204 Q5E9G3 PSME2_BOVIN 100.000 0.991667 1.00418 PSME2 - Proteasome activator complex subunit 2 - Bos taurus (Bovine) - PSME2 gene Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Indicus|evm.model.CM009500.1.205 Q9Y3B6 EMC9_HUMAN 93.237 0.985646 1.00481 EMC9 - ER membrane protein complex subunit 9 - Homo sapiens (Human) - EMC9 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Indicus|evm.model.CM009500.1.206 Q4U5R3 PSME1_BOVIN 99.598 0.992 1.00402 PSME1 - Proteasome activator complex subunit 1 - Bos taurus (Bovine) - PSME1 gene Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Indicus|evm.model.CM009500.1.207 A7YWN2 FITM1_BOVIN 100.000 0.993174 1.00342 FITM1 - Fat storage-inducing transmembrane protein 1 - Bos taurus (Bovine) - FITM1 gene Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol (By similarity). Indicus|evm.model.CM009500.1.208 Q5E9I8 DCA11_BOVIN 99.817 0.996344 1.00183 DCAF11 - DDB1- and CUL4-associated factor 11 - Bos taurus (Bovine) - DCAF11 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Indicus|evm.model.CM009500.1.209 Q16822 PCKGM_HUMAN 94.688 0.99688 1.00156 PCK2 - Phosphoenolpyruvate carboxykinase [GTP], mitochondrial precursor - Homo sapiens (Human) - PCK2 gene Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Indicus|evm.model.CM009500.1.210 P54845 NRL_HUMAN 93.860 0.863118 1.1097 NRL - Neural retina-specific leucine zipper protein - Homo sapiens (Human) - NRL gene Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001). Indicus|evm.model.CM009500.1.211 Q2KHY1 CPNE6_BOVIN 100.000 0.936027 1.06643 CPNE6 - Copine-6 - Bos taurus (Bovine) - CPNE6 gene Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes. Indicus|evm.model.CM009500.1.212 Q8ND23 CARL3_HUMAN 95.918 0.998543 1.00073 CARMIL3 - Capping protein, Arp2/3 and myosin-I linker protein 3 - Homo sapiens (Human) - CARMIL3 gene plasma membrane Indicus|evm.model.CM009500.1.214 Q8SPU8 DHRS4_BOVIN 97.849 0.992857 1.00358 DHRS4 - Dehydrogenase/reductase SDR family member 4 - Bos taurus (Bovine) - DHRS4 gene Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). Indicus|evm.model.CM009500.1.215 P0CG22 DR4L1_HUMAN 66.176 0.51938 0.459075 DHRS4L1 - Putative dehydrogenase/reductase SDR family member 4-like 1 - Homo sapiens (Human) - DHRS4L1 gene Putative oxidoreductase. Indicus|evm.model.CM009500.1.216 Q9MZ13 VDAC3_BOVIN 90.419 0.988095 0.59364 VDAC3 - Voltage-dependent anion-selective channel protein 3 - Bos taurus (Bovine) - VDAC3 gene Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. Indicus|evm.model.CM009500.1.217 P20821 GCSH_BOVIN 93.064 0.988506 1.00578 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Indicus|evm.model.CM009500.1.218 Q69FB3 JPH4_RAT 96.480 0.992051 0.998413 Jph4 - Junctophilin-4 - Rattus norvegicus (Rat) - Jph4 gene Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). Indicus|evm.model.CM009500.1.219 O75843 AP1G2_HUMAN 89.809 0.791919 1.26115 AP1G2 - AP-1 complex subunit gamma-like 2 - Homo sapiens (Human) - AP1G2 gene May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Indicus|evm.model.CM009500.1.220 Q8MKF1 THTPA_BOVIN 100.000 0.990909 1.00457 THTPA - Thiamine-triphosphatase - Bos taurus (Bovine) - THTPA gene Hydrolase highly specific for thiamine triphosphate (ThTP). Indicus|evm.model.CM009500.1.221 Q9C0A1 ZFHX2_HUMAN 86.477 0.995334 1 ZFHX2 - Zinc finger homeobox protein 2 - Homo sapiens (Human) - ZFHX2 gene Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli. Indicus|evm.model.CM009500.1.222 Q2KII6 NGDN_BOVIN 99.683 0.993671 1.00317 NGDN - Neuroguidin - Bos taurus (Bovine) - NGDN gene Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs. Indicus|evm.model.CM009500.1.223 Q9BE39 MYH7_BOVIN 97.927 0.498824 1.97674 MYH7 - Myosin-7 - Bos taurus (Bovine) - MYH7 gene Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Indicus|evm.model.CM009500.1.224 Q96DZ9 CKLF5_HUMAN 93.651 0.139326 1.99552 CMTM5 - CKLF-like MARVEL transmembrane domain-containing protein 5 - Homo sapiens (Human) - CMTM5 gene integral component of membrane Indicus|evm.model.CM009500.1.225 O43281 EFS_HUMAN 86.631 0.996441 1.00178 EFS - Embryonal Fyn-associated substrate - Homo sapiens (Human) - EFS gene Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity). Indicus|evm.model.CM009500.1.226 Q3SZQ2 S22AH_BOVIN 99.824 0.861492 1.15873 SLC22A17 - Solute carrier family 22 member 17 - Bos taurus (Bovine) - SLC22A17 gene Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). Indicus|evm.model.CM009500.1.227 Q28165 PABP2_BOVIN 100.000 0.993485 1.00327 PABPN1 - Polyadenylate-binding protein 2 - Bos taurus (Bovine) - PABPN1 gene Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (PubMed:7479061, PubMed:10481015). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (PubMed:12637556). Increases the affinity of poly(A) polymerase for RNA (PubMed:12637556, PubMed:12853485). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (By similarity). Binds to poly(A) and to poly(G) with high affinity (PubMed:7479061, PubMed:12637556). May protect the poly(A) tail from degradation (PubMed:7479061). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (By similarity). Indicus|evm.model.CM009500.1.228 Q45T69 B2CL2_CANLF 100.000 0.989691 1.00518 BCL2L2 - Bcl-2-like protein 2 - Canis lupus familiaris (Dog) - BCL2L2 gene Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX (By similarity). Indicus|evm.model.CM009500.1.229 Q9H7J1 PPR3E_HUMAN 91.398 0.992857 1.00358 PPP1R3E - Protein phosphatase 1 regulatory subunit 3E - Homo sapiens (Human) - PPP1R3E gene Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis. Indicus|evm.model.CM009500.1.230 Q8IX15 HOMEZ_HUMAN 86.745 0.933333 0.981818 HOMEZ - Homeobox and leucine zipper protein Homez - Homo sapiens (Human) - HOMEZ gene May function as a transcriptional regulator. Indicus|evm.model.CM009500.1.231 A8MTL3 R212B_HUMAN 85.603 0.941176 0.906667 RNF212B - RING finger protein 212B - Homo sapiens (Human) - RNF212B gene synaptonemal complex, SUMO transferase activity, homologous chromosome pairing at meiosis, protein sumoylation Indicus|evm.model.CM009500.1.232 Q9UHI5 LAT2_HUMAN 90.207 0.994329 0.988785 SLC7A8 - Large neutral amino acids transporter small subunit 2 - Homo sapiens (Human) - SLC7A8 gene Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Indicus|evm.model.CM009500.1.234 O77728 CEBPE_SHEEP 98.577 0.992908 1.00356 CEBPE - CCAAT/enhancer-binding protein epsilon - Ovis aries (Sheep) - CEBPE gene Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation. Indicus|evm.model.CM009500.1.235 Q9JJ93 CN119_MOUSE 88.732 0.986014 1.00704 MNCb-2990 - Uncharacterized protein C14orf119 homolog - Mus musculus (Mouse) - MNCb-2990 gene cytosol, mitochondrion Indicus|evm.model.CM009500.1.236 Q9UKV3 ACINU_HUMAN 91.878 0.998502 0.995526 ACIN1 - Apoptotic chromatin condensation inducer in the nucleus - Homo sapiens (Human) - ACIN1 gene Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Indicus|evm.model.CM009500.1.237 Q6PFX6 CAD24_MOUSE 87.964 0.997442 1.00128 Cdh24 - Cadherin-24 precursor - Mus musculus (Mouse) - Cdh24 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion (By similarity). Indicus|evm.model.CM009500.1.238 A5LHX3 PSB11_HUMAN 82.993 0.97931 0.966667 PSMB11 - Proteasome subunit beta type-11 precursor - Homo sapiens (Human) - PSMB11 gene The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). Indicus|evm.model.CM009500.1.239 Q32KL2 PSB5_BOVIN 100.000 0.992424 1.0038 PSMB5 - Proteasome subunit beta type-5 precursor - Bos taurus (Bovine) - PSMB5 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. Indicus|evm.model.CM009500.1.240 Q9H972 CN093_HUMAN 90.926 0.996303 1.00558 C14orf93 - Uncharacterized protein C14orf93 precursor - Homo sapiens (Human) - C14orf93 gene RNA binding Indicus|evm.model.CM009500.1.241 E1BKA3 AJUBA_BOVIN 100.000 0.996357 1.00182 AJUBA - LIM domain-containing protein ajuba - Bos taurus (Bovine) - AJUBA gene Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1 (By similarity). Indicus|evm.model.CM009500.1.242 Q9H6D7 HAUS4_HUMAN 87.879 0.994505 1.00275 HAUS4 - HAUS augmin-like complex subunit 4 - Homo sapiens (Human) - HAUS4 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Indicus|evm.model.CM009500.1.243 A7YW45 ANM5_BOVIN 99.843 0.996865 1.00157 PRMT5 - Protein arginine N-methyltransferase 5 - Bos taurus (Bovine) - PRMT5 gene Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties (By similarity). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (By similarity). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation. Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner. Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression. Symmetrically methylates NCL (By similarity). Methylates TP53; methylation might possibly affect TP53 target gene specificity (By similarity). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein B) and the interaction with tudor domain-containing protein TDRD6 (By similarity). Indicus|evm.model.CM009500.1.244 Q86U06 RBM23_HUMAN 85.313 0.99569 1.05695 RBM23 - Probable RNA-binding protein 23 - Homo sapiens (Human) - RBM23 gene RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343). Indicus|evm.model.CM009500.1.245 Q8IYK8 REM2_HUMAN 94.118 0.994135 1.00294 REM2 - GTP-binding protein REM 2 - Homo sapiens (Human) - REM2 gene Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. Indicus|evm.model.CM009500.1.246 Q7Z4F1 LRP10_HUMAN 89.224 0.974755 1 LRP10 - Low-density lipoprotein receptor-related protein 10 precursor - Homo sapiens (Human) - LRP10 gene Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). Indicus|evm.model.CM009500.1.247 Q9GLE4 MMP14_BOVIN 99.656 0.996569 1.00172 MMP14 - Matrix metalloproteinase-14 precursor - Bos taurus (Bovine) - MMP14 gene Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Indicus|evm.model.CM009500.1.248 P0C2B7 RM52_BOVIN 100.000 0.81457 1.21774 MRPL52 - 39S ribosomal protein L52, mitochondrial precursor - Bos taurus (Bovine) - MRPL52 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome, translation Indicus|evm.model.CM009500.1.250 Q9UM01 YLAT1_HUMAN 90.411 0.942699 1.05871 SLC7A7 - Y+L amino acid transporter 1 - Homo sapiens (Human) - SLC7A7 gene Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Indicus|evm.model.CM009500.1.251 Q3SYV3 OXA1L_BOVIN 99.099 0.995506 1.00907 OXA1L - Mitochondrial inner membrane protein OXA1L precursor - Bos taurus (Bovine) - OXA1L gene Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria (By similarity). Indicus|evm.model.CM009500.1.252 Q02370 NDUA2_BOVIN 100.000 0.714286 1.27273 NDUFA2 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 - Bos taurus (Bovine) - NDUFA2 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009500.1.254 Q5E983 EF1B_BOVIN 91.304 0.968085 0.417778 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Indicus|evm.model.CM009500.1.255 P62936 PPIA_PIG 98.780 0.987879 1.0061 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009500.1.256 Q5E983 EF1B_BOVIN 91.304 0.968085 0.417778 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Indicus|evm.model.CM009500.1.257 P62936 PPIA_PIG 98.925 0.8 0.70122 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009500.1.258 Q5EA59 ABHD4_BOVIN 100.000 0.957865 1.04094 ABHD4 - (Lyso)-N-acylphosphatidylethanolamine lipase - Bos taurus (Bovine) - ABHD4 gene Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. Indicus|evm.model.CM009500.1.259 Q5E9C2 DAD1_BOVIN 100.000 0.982456 1.00885 DAD1 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 - Bos taurus (Bovine) - DAD1 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Indicus|evm.model.CM009500.1.260 P01848 TRAC_HUMAN 60.417 0.858025 1.15714 TRAC - T cell receptor alpha chain constant - Homo sapiens (Human) - TRAC gene Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.261 B7Z8K6 TRDC_HUMAN 66.667 0.864407 1.15686 TRDC - T cell receptor delta constant - Homo sapiens (Human) - TRDC gene Constant region of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.262 Q93079 H2B1H_HUMAN 89.552 0.970149 0.531746 H2BC9 - Histone H2B type 1-H - Homo sapiens (Human) - H2BC9 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009500.1.263 A0JD36 TRDV2_HUMAN 65.217 0.857143 1.15652 TRDV2 - T cell receptor delta variable 2 precursor - Homo sapiens (Human) - TRDV2 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.264 A0A0A6YYC5 TVA14_HUMAN 48.315 0.353909 2.09483 TRAV14DV4 - T cell receptor alpha variable 14/delta variable 4 precursor - Homo sapiens (Human) - TRAV14DV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.265 P15103 GLNA_BOVIN 82.447 0.708333 0.707775 GLUL - Glutamine synthetase - Bos taurus (Bovine) - GLUL gene Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Indicus|evm.model.CM009500.1.266 A0A0B4J266 TVA41_HUMAN 62.500 0.738255 1.33036 TRAV41 - T cell receptor alpha variable 41 precursor - Homo sapiens (Human) - TRAV41 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.267 A0JD32 TV382_HUMAN 67.257 0.982301 0.974138 TRAV38-2DV8 - T cell receptor alpha variable 38-2/delta variable 8 precursor - Homo sapiens (Human) - TRAV38-2DV8 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.268 A0A0B4J277 TVA22_HUMAN 60.674 0.458333 1.74545 TRAV22 - T cell receptor alpha variable 22 precursor - Homo sapiens (Human) - TRAV22 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.269 A0A0B4J265 TVAZ2_HUMAN 66.316 0.594937 1.44954 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.270 A0A0B4J265 TVAZ2_HUMAN 70.652 0.572327 1.45872 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.271 A0A1B0GX56 TRDV1_HUMAN 66.087 0.942149 1.05217 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.272 A0A0B4J276 TVA25_HUMAN 63.441 0.661871 1.27523 TRAV25 - T cell receptor alpha variable 25 precursor - Homo sapiens (Human) - TRAV25 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.273 P06322 TVA1_RABIT 71.795 0.219653 1.29104 T-cell receptor alpha chain V region RL-5 precursor - Oryctolagus cuniculus (Rabbit) Indicus|evm.model.CM009500.1.274 A0A0B4J276 TVA25_HUMAN 57.609 0.710938 1.17431 TRAV25 - T cell receptor alpha variable 25 precursor - Homo sapiens (Human) - TRAV25 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.275 A0A1B0GX56 TRDV1_HUMAN 68.000 0.194118 4.43478 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.276 A0A1B0GX56 TRDV1_HUMAN 67.000 0.553073 1.55652 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.277 A0A1B0GX56 TRDV1_HUMAN 63.559 0.676301 1.50435 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.278 A0A1B0GX56 TRDV1_HUMAN 65.306 0.305994 2.75652 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.279 A0A075B6X5 TVA18_HUMAN 77.049 0.106383 5.08108 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.280 A0A0B4J277 TVA22_HUMAN 60.870 0.256966 2.93636 TRAV22 - T cell receptor alpha variable 22 precursor - Homo sapiens (Human) - TRAV22 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.281 A0A1B0GX56 TRDV1_HUMAN 69.903 0.406375 2.18261 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.282 A0A1B0GX56 TRDV1_HUMAN 72.165 0.277457 3.0087 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.283 A0A1B0GX56 TRDV1_HUMAN 60.870 0.783582 1.16522 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.284 A0A1B0GX56 TRDV1_HUMAN 63.725 0.594118 1.47826 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.285 A0A0B4J263 TVA39_HUMAN 65.766 0.778571 1.27273 TRAV39 - T cell receptor alpha variable 39 precursor - Homo sapiens (Human) - TRAV39 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.286 A0JD32 TV382_HUMAN 73.684 0.94958 1.02586 TRAV38-2DV8 - T cell receptor alpha variable 38-2/delta variable 8 precursor - Homo sapiens (Human) - TRAV38-2DV8 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.287 A0JD32 TV382_HUMAN 73.684 0.94958 1.02586 TRAV38-2DV8 - T cell receptor alpha variable 38-2/delta variable 8 precursor - Homo sapiens (Human) - TRAV38-2DV8 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.288 A0A0B4J264 TV381_HUMAN 67.544 0.94958 1.02586 TRAV38-1 - T cell receptor alpha variable 38-1 precursor - Homo sapiens (Human) - TRAV38-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.289 P0DPF4 TVA35_HUMAN 75.269 0.304636 2.74545 TRAV35 - T cell receptor alpha variable 35 precursor - Homo sapiens (Human) - TRAV35 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.290 P01737 TVA84_HUMAN 70.833 0.236908 3.54867 TRAV8-4 - T cell receptor alpha variable 8-4 precursor - Homo sapiens (Human) - TRAV8-4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.291 A0A087WT03 TVAZ1_HUMAN 67.593 0.810606 1.21101 TRAV26-1 - T cell receptor alpha variable 26-1 precursor - Homo sapiens (Human) - TRAV26-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.292 A0A1B0GX56 TRDV1_HUMAN 66.957 0.926829 1.06957 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.293 A0A1B0GX56 TRDV1_HUMAN 61.538 0.899225 1.12174 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.294 A0A075B6X5 TVA18_HUMAN 79.570 0.245989 3.36937 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.295 A0A0A6YYC5 TVA14_HUMAN 75.862 0.934959 1.06034 TRAV14DV4 - T cell receptor alpha variable 14/delta variable 4 precursor - Homo sapiens (Human) - TRAV14DV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.297 A0A1B0GX56 TRDV1_HUMAN 67.241 0.684524 1.46087 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.299 A0A1B0GX56 TRDV1_HUMAN 70.435 0.942149 1.05217 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.300 A0A0B4J265 TVAZ2_HUMAN 68.478 0.464286 1.79817 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.301 A0A075B6W5 TVA23_HUMAN 71.233 0.116317 5.1157 TRAV23DV6 - T cell receptor alpha variable 23/delta variable 6 precursor - Homo sapiens (Human) - TRAV23DV6 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.302 P01737 TVA84_HUMAN 69.149 0.709924 1.15929 TRAV8-4 - T cell receptor alpha variable 8-4 precursor - Homo sapiens (Human) - TRAV8-4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.303 A0A0B4J274 TVA20_HUMAN 80.357 0.832061 1.16964 TRAV20 - T cell receptor alpha variable 20 precursor - Homo sapiens (Human) - TRAV20 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.304 A0A0B4J265 TVAZ2_HUMAN 69.725 0.404494 2.44954 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.305 A0A0A6YYK7 TVA19_HUMAN 60.909 0.601156 1.49138 TRAV19 - T cell receptor alpha variable 19 precursor - Homo sapiens (Human) - TRAV19 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.306 A0A075B6X5 TVA18_HUMAN 79.570 0.198276 4.18018 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.307 A0A0A6YYK6 TVA16_HUMAN 76.852 0.685897 1.43119 TRAV16 - T cell receptor alpha variable 16 precursor - Homo sapiens (Human) - TRAV16 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.308 P01739 TVA2_MOUSE 63.158 0.298413 2.38636 T-cell receptor alpha chain V region 2B4 precursor - Mus musculus (Mouse) Indicus|evm.model.CM009500.1.309 A0A0A6YYC5 TVA14_HUMAN 77.451 0.980583 0.887931 TRAV14DV4 - T cell receptor alpha variable 14/delta variable 4 precursor - Homo sapiens (Human) - TRAV14DV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.310 A0A0B4J265 TVAZ2_HUMAN 68.807 0.715232 1.38532 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.311 A0A1B0GX56 TRDV1_HUMAN 70.707 0.398374 2.13913 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.312 A0A0B4J276 TVA25_HUMAN 63.441 0.661871 1.27523 TRAV25 - T cell receptor alpha variable 25 precursor - Homo sapiens (Human) - TRAV25 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.313 A0A1B0GX56 TRDV1_HUMAN 64.348 0.863636 1.14783 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.314 A0A0B4J265 TVAZ2_HUMAN 63.855 0.465909 1.61468 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.315 A0A0A6YYJ7 TVA83_HUMAN 71.212 0.162907 3.53097 TRAV8-3 - T cell receptor alpha variable 8-3 precursor - Homo sapiens (Human) - TRAV8-3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.316 A0A1B0GX56 TRDV1_HUMAN 64.348 0.596859 1.66087 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.317 A0A0A6YYJ7 TVA83_HUMAN 72.973 0.696203 1.39823 TRAV8-3 - T cell receptor alpha variable 8-3 precursor - Homo sapiens (Human) - TRAV8-3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.318 A0A1B0GX56 TRDV1_HUMAN 58.974 0.601036 1.67826 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.319 A0A0A6YYJ7 TVA83_HUMAN 67.416 0.214286 3.59292 TRAV8-3 - T cell receptor alpha variable 8-3 precursor - Homo sapiens (Human) - TRAV8-3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.320 A0A0B4J241 TVAM1_HUMAN 66.667 0.443089 2.19643 TRAV13-1 - T cell receptor alpha variable 13-1 precursor - Homo sapiens (Human) - TRAV13-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.321 A0A075B6T6 TVAL2_HUMAN 63.158 0.497354 1.67257 TRAV12-2 - T cell receptor alpha variable 12-2 precursor - Homo sapiens (Human) - TRAV12-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.322 A0A0A6YYC5 TVA14_HUMAN 75.000 0.966387 1.02586 TRAV14DV4 - T cell receptor alpha variable 14/delta variable 4 precursor - Homo sapiens (Human) - TRAV14DV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.323 A0A0B4J268 TVA4_HUMAN 74.312 0.467532 2.11927 TRAV4 - T cell receptor alpha variable 4 precursor - Homo sapiens (Human) - TRAV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.324 A0A075B6T8 TVA91_HUMAN 77.907 0.833333 0.910714 TRAV9-1 - T cell receptor alpha variable 9-1 precursor - Homo sapiens (Human) - TRAV9-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.325 A0A1B0GX56 TRDV1_HUMAN 65.217 0.633333 1.56522 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.326 A0A075B6T8 TVA91_HUMAN 87.273 0.145946 3.30357 TRAV9-1 - T cell receptor alpha variable 9-1 precursor - Homo sapiens (Human) - TRAV9-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.327 P01737 TVA84_HUMAN 66.337 0.757576 1.16814 TRAV8-4 - T cell receptor alpha variable 8-4 precursor - Homo sapiens (Human) - TRAV8-4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.328 A0A087WT03 TVAZ1_HUMAN 65.263 0.266289 3.23853 TRAV26-1 - T cell receptor alpha variable 26-1 precursor - Homo sapiens (Human) - TRAV26-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.329 A0A0B4J276 TVA25_HUMAN 59.140 0.661871 1.27523 TRAV25 - T cell receptor alpha variable 25 precursor - Homo sapiens (Human) - TRAV25 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.330 A0A1B0GX56 TRDV1_HUMAN 60.000 0.596859 1.66087 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.331 A0A087WT03 TVAZ1_HUMAN 62.037 0.743056 1.3211 TRAV26-1 - T cell receptor alpha variable 26-1 precursor - Homo sapiens (Human) - TRAV26-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.332 A0A0B4J265 TVAZ2_HUMAN 65.060 0.344538 2.18349 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.333 A0A1B0GX56 TRDV1_HUMAN 67.826 0.942149 1.05217 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.334 A0A0B4J276 TVA25_HUMAN 59.783 0.710938 1.17431 TRAV25 - T cell receptor alpha variable 25 precursor - Homo sapiens (Human) - TRAV25 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.335 A0A0B4J277 TVA22_HUMAN 69.091 0.908333 1.09091 TRAV22 - T cell receptor alpha variable 22 precursor - Homo sapiens (Human) - TRAV22 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.336 A0A0B4J275 TVA17_HUMAN 69.444 0.371528 2.57143 TRAV17 - T cell receptor alpha variable 17 precursor - Homo sapiens (Human) - TRAV17 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.337 A0A0A6YYC5 TVA14_HUMAN 76.724 0.934959 1.06034 TRAV14DV4 - T cell receptor alpha variable 14/delta variable 4 precursor - Homo sapiens (Human) - TRAV14DV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.338 A0A0B4J241 TVAM1_HUMAN 70.652 0.189189 4.29464 TRAV13-1 - T cell receptor alpha variable 13-1 precursor - Homo sapiens (Human) - TRAV13-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.339 A0A0B4J249 TVA5_HUMAN 66.964 0.853846 1.15044 TRAV5 - T cell receptor alpha variable 5 precursor - Homo sapiens (Human) - TRAV5 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.340 A0A0B4J268 TVA4_HUMAN 76.147 0.964286 1.02752 TRAV4 - T cell receptor alpha variable 4 precursor - Homo sapiens (Human) - TRAV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.341 A0A087WT03 TVAZ1_HUMAN 62.963 0.703947 1.3945 TRAV26-1 - T cell receptor alpha variable 26-1 precursor - Homo sapiens (Human) - TRAV26-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.342 A0A1B0GX56 TRDV1_HUMAN 65.217 0.926829 1.06957 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.343 A0A075B6X5 TVA18_HUMAN 79.570 0.29582 2.8018 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.344 P06322 TVA1_RABIT 71.795 0.219653 1.29104 T-cell receptor alpha chain V region RL-5 precursor - Oryctolagus cuniculus (Rabbit) Indicus|evm.model.CM009500.1.345 A0A1B0GX56 TRDV1_HUMAN 68.696 0.942149 1.05217 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Indicus|evm.model.CM009500.1.346 A0A087WT03 TVAZ1_HUMAN 64.815 0.324242 3.02752 TRAV26-1 - T cell receptor alpha variable 26-1 precursor - Homo sapiens (Human) - TRAV26-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.347 A0A0B4J241 TVAM1_HUMAN 68.817 0.186475 4.35714 TRAV13-1 - T cell receptor alpha variable 13-1 precursor - Homo sapiens (Human) - TRAV13-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.348 A0A0B4J265 TVAZ2_HUMAN 68.807 0.402985 2.45872 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.349 A0A0B4J277 TVA22_HUMAN 70.652 0.435407 1.9 TRAV22 - T cell receptor alpha variable 22 precursor - Homo sapiens (Human) - TRAV22 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.350 A0A0B4J274 TVA20_HUMAN 76.596 0.371429 2.1875 TRAV20 - T cell receptor alpha variable 20 precursor - Homo sapiens (Human) - TRAV20 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.351 A0A0B4J244 TVA3_HUMAN 81.373 0.495098 1.78947 TRAV3 - T cell receptor alpha variable 3 precursor - Homo sapiens (Human) - TRAV3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.352 A0A0B4J244 TVA3_HUMAN 81.633 0.250646 3.39474 TRAV3 - T cell receptor alpha variable 3 precursor - Homo sapiens (Human) - TRAV3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.353 A0A0B4J244 TVA3_HUMAN 82.653 0.184762 4.60526 TRAV3 - T cell receptor alpha variable 3 precursor - Homo sapiens (Human) - TRAV3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.354 Q8NGC4 O10G3_HUMAN 85.632 0.711934 0.776358 OR10G3 - Olfactory receptor 10G3 - Homo sapiens (Human) - OR10G3 gene Odorant receptor. Indicus|evm.model.CM009500.1.356 Q9Y467 SALL2_HUMAN 91.097 0.873636 1.09235 SALL2 - Sal-like protein 2 - Homo sapiens (Human) - SALL2 gene Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure. Indicus|evm.model.CM009500.1.357 Q86U44 MTA70_HUMAN 97.931 0.996558 1.00172 METTL3 - N6-adenosine-methyltransferase catalytic subunit - Homo sapiens (Human) - METTL3 gene The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:28297716, PubMed:30428350, PubMed:29506078, PubMed:29348140, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). Indicus|evm.model.CM009500.1.358 Q0P5K4 TOX4_BOVIN 100.000 0.996774 1.00162 TOX4 - TOX high mobility group box family member 4 - Bos taurus (Bovine) - TOX4 gene Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Indicus|evm.model.CM009500.1.359 Q8WUD1 RAB2B_HUMAN 96.759 0.990783 1.00463 RAB2B - Ras-related protein Rab-2B - Homo sapiens (Human) - RAB2B gene Required for protein transport from the endoplasmic reticulum to the Golgi complex. Indicus|evm.model.CM009500.1.360 Q9HCK8 CHD8_HUMAN 94.351 0.99922 0.993026 CHD8 - Chromodomain-helicase-DNA-binding protein 8 - Homo sapiens (Human) - CHD8 gene DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Indicus|evm.model.CM009500.1.361 Q9Y5B9 SP16H_HUMAN 99.713 0.998092 1.00096 SUPT16H - FACT complex subunit SPT16 - Homo sapiens (Human) - SUPT16H gene Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Indicus|evm.model.CM009500.1.362 Q9GLM3 RPGR1_BOVIN 93.873 0.998357 0.996724 RPGRIP1 - X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 - Bos taurus (Bovine) - RPGRIP1 gene May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells. Indicus|evm.model.CM009500.1.363 Q99880 H2B1L_HUMAN 96.386 0.97619 0.666667 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009500.1.364 O77768 HNRPC_RABIT 94.788 0.99322 0.964052 HNRNPC - Heterogeneous nuclear ribonucleoprotein C - Oryctolagus cuniculus (Rabbit) - HNRNPC gene Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing. Indicus|evm.model.CM009500.1.365 P0C7T8 TM253_HUMAN 84.925 0.965517 0.935484 TMEM253 - Transmembrane protein 253 - Homo sapiens (Human) - TMEM253 gene Indicus|evm.model.CM009500.1.366 Q9P2Y4 ZN219_HUMAN 90.720 0.997211 0.993075 ZNF219 - Zinc finger protein 219 - Homo sapiens (Human) - ZNF219 gene Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). Indicus|evm.model.CM009500.1.367 Q8TER5 ARH40_HUMAN 89.093 0.998685 1.00132 ARHGEF40 - Rho guanine nucleotide exchange factor 40 - Homo sapiens (Human) - ARHGEF40 gene May act as a guanine nucleotide exchange factor (GEF). Indicus|evm.model.CM009500.1.368 Q9H1E1 RNAS7_HUMAN 71.795 0.987261 1.00641 RNASE7 - Ribonuclease 7 precursor - Homo sapiens (Human) - RNASE7 gene Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% Indicus|evm.model.CM009500.1.369 Q5GAM7 RNS13_MOUSE 70.588 0.987013 1.00654 Rnase13 - Probable inactive ribonuclease-like protein 13 precursor - Mus musculus (Mouse) - Rnase13 gene Does not exhibit any ribonuclease activity. Indicus|evm.model.CM009500.1.370 Q3T077 TPPP2_BOVIN 100.000 0.988372 1.00585 TPPP2 - Tubulin polymerization-promoting protein family member 2 - Bos taurus (Bovine) - TPPP2 gene Probable regulator of microtubule dynamics required for sperm motility (By similarity). In contrast to other members of the family, has no microtubule bundling activity (By similarity). Indicus|evm.model.CM009500.1.371 Q3ZBA8 NDRG2_BOVIN 88.235 0.993671 0.885154 NDRG2 - Protein NDRG2 - Bos taurus (Bovine) - NDRG2 gene Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). Indicus|evm.model.CM009500.1.372 Q9NP94 S39A2_HUMAN 78.317 0.993548 1.00324 SLC39A2 - Zinc transporter ZIP2 - Homo sapiens (Human) - SLC39A2 gene Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis. Indicus|evm.model.CM009500.1.373 Q2TBP8 MET17_BOVIN 99.784 0.99568 1.00216 METTL17 - Methyltransferase-like protein 17, mitochondrial precursor - Bos taurus (Bovine) - METTL17 gene Probable S-adenosyl-L-methionine-dependent RNA methyltransferase required to stabilize the mitochondrial small ribosomal subunit (mt-SSU). Required for protein translation in mitochondria. Indicus|evm.model.CM009500.1.374 P47784 RNAS2_PONPY 57.143 0.987421 0.987578 RNASE2 - Non-secretory ribonuclease precursor - Pongo pygmaeus (Bornean orangutan) - RNASE2 gene This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities. Indicus|evm.model.CM009500.1.376 P00669 RNS_BOVIN 100.000 0.986755 1.00667 SRN - Seminal ribonuclease precursor - Bos taurus (Bovine) - SRN gene This enzyme hydrolyzes both single- and double-stranded RNA. Indicus|evm.model.CM009500.1.377 P39873 RNBR_BOVIN 100.000 0.988095 1.00599 BRN - Brain ribonuclease precursor - Bos taurus (Bovine) - BRN gene ribonuclease activity, RNA phosphodiester bond hydrolysis Indicus|evm.model.CM009500.1.378 P56851 EP3B_HUMAN 55.782 0.884146 1.11565 EDDM3B - Epididymal secretory protein E3-beta precursor - Homo sapiens (Human) - EDDM3B gene Possible function in sperm maturation. Indicus|evm.model.CM009500.1.379 P15467 RNAS4_BOVIN 97.959 0.729323 1.11765 RNASE4 - Ribonuclease 4 - Bos taurus (Bovine) - RNASE4 gene This RNase has marked specificity towards the 3' side of uridine nucleotides. Indicus|evm.model.CM009500.1.380 P10152 ANG1_BOVIN 71.233 0.973154 1.00676 ANG1 - Angiogenin-1 precursor - Bos taurus (Bovine) - ANG1 gene Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity. Indicus|evm.model.CM009500.1.381 Q8VCY6 UTP6_MOUSE 68.624 0.992857 0.938023 Utp6 - U3 small nucleolar RNA-associated protein 6 homolog - Mus musculus (Mouse) - Utp6 gene Involved in nucleolar processing of pre-18S ribosomal RNA. Indicus|evm.model.CM009500.1.382 Q9H1E1 RNAS7_HUMAN 68.590 0.91716 1.08333 RNASE7 - Ribonuclease 7 precursor - Homo sapiens (Human) - RNASE7 gene Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% Indicus|evm.model.CM009500.1.383 Q28521 ROA1_MACMU 70.000 0.852273 0.55 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Macaca mulatta (Rhesus macaque) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins (By similarity). Indicus|evm.model.CM009500.1.384 P61823 RNAS1_BOVIN 100.000 0.986755 1.00667 RNASE1 - Ribonuclease pancreatic precursor - Bos taurus (Bovine) - RNASE1 gene Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA. Indicus|evm.model.CM009500.1.385 P08904 RNAS6_BOVIN 99.351 0.987097 1.00649 RNASE6 - Ribonuclease K6 precursor - Bos taurus (Bovine) - RNASE6 gene Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:3926759). Has potent antimicrobial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (By similarity). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity). Probably contributes to urinary tract sterility (By similarity). Bactericidal activity is independent of RNase activity (By similarity). Indicus|evm.model.CM009500.1.386 P56851 EP3B_HUMAN 54.422 0.884146 1.11565 EDDM3B - Epididymal secretory protein E3-beta precursor - Homo sapiens (Human) - EDDM3B gene Possible function in sperm maturation. Indicus|evm.model.CM009500.1.387 P15467 RNAS4_BOVIN 98.305 0.790541 1.2437 RNASE4 - Ribonuclease 4 - Bos taurus (Bovine) - RNASE4 gene This RNase has marked specificity towards the 3' side of uridine nucleotides. Indicus|evm.model.CM009500.1.388 P10152 ANG1_BOVIN 99.324 0.986577 1.00676 ANG1 - Angiogenin-1 precursor - Bos taurus (Bovine) - ANG1 gene Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity. Indicus|evm.model.CM009500.1.389 P80929 ANG2_BOVIN 99.187 0.606965 1.63415 ANG2 - Angiogenin-2 - Bos taurus (Bovine) - ANG2 gene Binds tightly to placental ribonuclease inhibitor and has very low ribonuclease activity. Has potent angiogenic activity. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Indicus|evm.model.CM009500.1.390 Q8NH40 OR6S1_HUMAN 56.934 0.38326 0.685801 OR6S1 - Olfactory receptor 6S1 - Homo sapiens (Human) - OR6S1 gene Odorant receptor. Indicus|evm.model.CM009500.1.391 Q5GAN4 RNS12_HUMAN 67.347 0.75 1.30612 RNASE12 - Probable inactive ribonuclease-like protein 12 precursor - Homo sapiens (Human) - RNASE12 gene Does not exhibit any ribonuclease activity. Indicus|evm.model.CM009500.1.392 Q7YRH1 RNAS9_CHLAE 47.059 0.737705 0.897059 RNASE9 - Inactive ribonuclease-like protein 9 precursor - Chlorocebus aethiops (Green monkey) - RNASE9 gene Does not exhibit any ribonuclease activity. Indicus|evm.model.CM009500.1.394 Q70IB2 RNS10_BOVIN 100.000 0.990566 1.00474 RNASE10 - Inactive ribonuclease-like protein 10 precursor - Bos taurus (Bovine) - RNASE10 gene Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity). Indicus|evm.model.CM009500.1.395 P55859 PNPH_BOVIN 99.654 0.993103 1.00346 PNP - Purine nucleoside phosphorylase - Bos taurus (Bovine) - PNP gene Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity). Indicus|evm.model.CM009500.1.396 P55859 PNPH_BOVIN 91.411 0.981818 0.570934 PNP - Purine nucleoside phosphorylase - Bos taurus (Bovine) - PNP gene Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity). Indicus|evm.model.CM009500.1.397 Q4R6W2 PP4P1_MACFA 99.648 0.992982 1.00352 PIP4P1 - Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase - Macaca fascicularis (Crab-eating macaque) - PIP4P1 gene Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (By similarity). May play a role in the regulation of cellular cholesterol metabolism (By similarity). Indicus|evm.model.CM009500.1.398 P23196 APEX1_BOVIN 99.686 0.99373 1.00314 APEX1 - DNA-(apurinic or apyrimidinic site) endonuclease - Bos taurus (Bovine) - APEX1 gene Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA (By similarity). Indicus|evm.model.CM009500.1.399 Q0VCI1 OSGEP_BOVIN 100.000 0.994048 1.00299 OSGEP - Probable tRNA N6-adenosine threonylcarbamoyltransferase - Bos taurus (Bovine) - OSGEP gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. Indicus|evm.model.CM009500.1.400 A6NCF5 KLH33_HUMAN 89.869 0.151567 6.58537 KLHL33 - Kelch-like protein 33 - Homo sapiens (Human) - KLHL33 gene Indicus|evm.model.CM009500.1.401 Q9UGN5 PARP2_HUMAN 88.830 0.971581 0.965695 PARP2 - Poly [ADP-ribose] polymerase 2 - Homo sapiens (Human) - PARP2 gene Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:25043379, PubMed:27471034, PubMed:32028527, PubMed:32939087). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379, PubMed:30321391). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:32939087). Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (PubMed:25043379). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site (PubMed:28190768, PubMed:32028527). PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:10364231, PubMed:32939087). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034). Indicus|evm.model.CM009500.1.402 Q9NPC3 CIP1_HUMAN 95.307 0.992806 1.00361 CCNB1IP1 - E3 ubiquitin-protein ligase CCNB1IP1 - Homo sapiens (Human) - CCNB1IP1 gene Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. Indicus|evm.model.CM009500.1.403 Q0P5H9 TTC5_BOVIN 99.772 0.995455 1 TTC5 - Tetratricopeptide repeat protein 5 - Bos taurus (Bovine) - TTC5 gene Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity). Indicus|evm.model.CM009500.1.404 Q07537 GALT1_BOVIN 70.244 0.807692 0.372093 GALNT1 - Polypeptide N-acetylgalactosaminyltransferase 1 - Bos taurus (Bovine) - GALNT1 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. Indicus|evm.model.CM009500.1.405 Q8NGC7 O11H6_HUMAN 63.462 0.953704 0.327273 OR11H6 - Olfactory receptor 11H6 - Homo sapiens (Human) - OR11H6 gene Odorant receptor. Indicus|evm.model.CM009500.1.406 Q8NGC9 O11H4_HUMAN 60.963 0.738095 0.777778 OR11H4 - Olfactory receptor 11H4 - Homo sapiens (Human) - OR11H4 gene Odorant receptor. Indicus|evm.model.CM009500.1.407 A4IFF3 TTC9C_BOVIN 97.661 0.988372 1.00585 TTC9C - Tetratricopeptide repeat protein 9C - Bos taurus (Bovine) - TTC9C gene Indicus|evm.model.CM009500.1.408 Q8NGD5 OR4KE_HUMAN 63.636 0.910256 0.503226 OR4K14 - Olfactory receptor 4K14 - Homo sapiens (Human) - OR4K14 gene Odorant receptor. Indicus|evm.model.CM009500.1.409 B2RN74 O11HC_HUMAN 68.182 0.825758 0.404908 OR11H12 - Olfactory receptor 11H12 - Homo sapiens (Human) - OR11H12 gene Odorant receptor. Indicus|evm.model.CM009500.1.410 Q8NGD0 OR4M1_HUMAN 93.333 0.992188 0.817891 OR4M1 - Olfactory receptor 4M1 - Homo sapiens (Human) - OR4M1 gene Odorant receptor. Indicus|evm.model.CM009500.1.411 Q8NH41 OR4KF_HUMAN 69.822 0.982456 0.491379 OR4K15 - Olfactory receptor 4K15 - Homo sapiens (Human) - OR4K15 gene Odorant receptor. Indicus|evm.model.CM009500.1.412 Q8NGD4 OR4K1_HUMAN 91.453 0.983051 0.379421 OR4K1 - Olfactory receptor 4K1 - Homo sapiens (Human) - OR4K1 gene Odorant receptor. Indicus|evm.model.CM009500.1.413 Q8NH43 OR4L1_HUMAN 80.921 0.980519 0.49359 OR4L1 - Olfactory receptor 4L1 - Homo sapiens (Human) - OR4L1 gene Odorant receptor. Indicus|evm.model.CM009500.1.414 Q8NH43 OR4L1_HUMAN 80.263 0.980519 0.49359 OR4L1 - Olfactory receptor 4L1 - Homo sapiens (Human) - OR4L1 gene Odorant receptor. Indicus|evm.model.CM009500.1.416 Q8NGB9 OR4F6_HUMAN 75.563 0.990415 1.00321 OR4F6 - Olfactory receptor 4F6 - Homo sapiens (Human) - OR4F6 gene Odorant receptor. Indicus|evm.model.CM009500.1.417 Q6IEY1 OR4F3_HUMAN 73.529 0.937716 0.926282 OR4F3 - Olfactory receptor 4F3/4F16/4F29 - Homo sapiens (Human) - OR4F3 gene Odorant receptor. Indicus|evm.model.CM009500.1.418 Q6IEY1 OR4F3_HUMAN 72.258 0.922388 1.07372 OR4F3 - Olfactory receptor 4F3/4F16/4F29 - Homo sapiens (Human) - OR4F3 gene Odorant receptor. Indicus|evm.model.CM009500.1.419 P62752 RL23A_RAT 93.519 0.768116 0.884615 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009500.1.420 Q643R3 LPCT4_HUMAN 91.337 0.99619 1.00191 LPCAT4 - Lysophospholipid acyltransferase LPCAT4 - Homo sapiens (Human) - LPCAT4 gene Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. Indicus|evm.model.CM009500.1.421 Q86Y26 NUTM1_HUMAN 68.003 0.998238 1.00265 NUTM1 - NUT family member 1 - Homo sapiens (Human) - NUTM1 gene Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. Indicus|evm.model.CM009500.1.422 Q9CQS2 NOP10_MOUSE 95.312 0.969231 1.01562 Nop10 - H/ACA ribonucleoprotein complex subunit 3 - Mus musculus (Mouse) - Nop10 gene Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). Indicus|evm.model.CM009500.1.423 Q9UHW9 S12A6_HUMAN 98.870 0.911905 1.09565 SLC12A6 - Solute carrier family 12 member 6 - Homo sapiens (Human) - SLC12A6 gene Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. Indicus|evm.model.CM009500.1.424 Q3T0K8 EMC4_BOVIN 100.000 0.98913 1.00546 EMC4 - ER membrane protein complex subunit 4 - Bos taurus (Bovine) - EMC4 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Indicus|evm.model.CM009500.1.425 Q9H079 KTBL1_HUMAN 93.092 0.993443 1.00329 KATNBL1 - KATNB1-like protein 1 - Homo sapiens (Human) - KATNBL1 gene Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro. Indicus|evm.model.CM009500.1.426 A5PJA8 EMC7_BOVIN 99.585 0.991736 1.00415 EMC7 - ER membrane protein complex subunit 7 precursor - Bos taurus (Bovine) - EMC7 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Indicus|evm.model.CM009500.1.427 P08912 ACM5_HUMAN 90.226 0.996248 1.00188 CHRM5 - Muscarinic acetylcholine receptor M5 - Homo sapiens (Human) - CHRM5 gene The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Indicus|evm.model.CM009500.1.428 Q9NQS1 AVEN_HUMAN 78.022 0.701031 1.07182 AVEN - Cell death regulator Aven - Homo sapiens (Human) - AVEN gene Protects against apoptosis mediated by Apaf-1. Indicus|evm.model.CM009500.1.430 Q15413 RYR3_HUMAN 92.500 0.530201 0.0305955 RYR3 - Ryanodine receptor 3 - Homo sapiens (Human) - RYR3 gene Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling. Indicus|evm.model.CM009500.1.433 Q32L59 TMC5B_BOVIN 86.895 0.993506 0.877493 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Indicus|evm.model.CM009500.1.435 Q8WNY1 GREM1_MACMU 100.000 0.989189 1.00543 GREM1 - Gremlin-1 precursor - Macaca mulatta (Rhesus macaque) - GREM1 gene Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). Indicus|evm.model.CM009500.1.436 P01165 7B2_PIG 97.596 0.971831 1.02899 SCG5 - Neuroendocrine protein 7B2 precursor - Sus scrofa (Pig) - SCG5 gene Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. Indicus|evm.model.CM009500.1.437 Q3KRB8 RHGBB_HUMAN 87.727 0.213867 3.83521 ARHGAP11B - Inactive Rho GTPase-activating protein 11B precursor - Homo sapiens (Human) - ARHGAP11B gene Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503, PubMed:27957544, PubMed:30484771, PubMed:32554627). Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion (PubMed:25721503). Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation (PubMed:31883789). Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development (PubMed:25721503, PubMed:27957544). Indicus|evm.model.CM009500.1.438 Q866T7 CXD2_BOVIN 100.000 0.993789 1.00312 GJD2 - Gap junction delta-2 protein - Bos taurus (Bovine) - GJD2 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009500.1.439 Q6P640 ACTC_XENTR 100.000 0.994709 1.00265 actc1 - Actin, alpha cardiac muscle 1 precursor - Xenopus tropicalis (Western clawed frog) - actc1 gene Actins are highly conserved proteins that are involved in various types of cell motility. Indicus|evm.model.CM009500.1.440 O60306 AQR_HUMAN 91.925 0.998606 0.96633 AQR - RNA helicase aquarius - Homo sapiens (Human) - AQR gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). Indicus|evm.model.CM009500.1.441 Q6IQ21 ZN770_HUMAN 80.202 0.997097 0.997106 ZNF770 - Zinc finger protein 770 - Homo sapiens (Human) - ZNF770 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009500.1.442 Q2HJF5 DPH6_BOVIN 99.625 0.992537 1.00375 DPH6 - Diphthine--ammonia ligase - Bos taurus (Bovine) - DPH6 gene Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity). Indicus|evm.model.CM009500.1.444 Q5E9S8 CDIN1_BOVIN 100.000 0.987952 0.590747 CDIN1 - CDAN1-interacting nuclease 1 - Bos taurus (Bovine) - CDIN1 gene Plays a role in erythroid cell differentiation. Indicus|evm.model.CM009500.1.445 O14770 MEIS2_HUMAN 99.371 0.995816 1.0021 MEIS2 - Homeobox protein Meis2 - Homo sapiens (Human) - MEIS2 gene Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. Indicus|evm.model.CM009500.1.446 Q9D9D5 TMC5A_MOUSE 75.248 0.912387 1.09241 Tmco5a - Transmembrane and coiled-coil domain-containing protein 5A - Mus musculus (Mouse) - Tmco5a gene Indicus|evm.model.CM009500.1.448 Q7Z699 SPRE1_HUMAN 92.809 0.995495 1 SPRED1 - Sprouty-related, EVH1 domain-containing protein 1 - Homo sapiens (Human) - SPRED1 gene Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Indicus|evm.model.CM009500.1.449 Q52LJ0 FA98B_HUMAN 94.545 0.826633 0.919169 FAM98B - Protein FAM98B - Homo sapiens (Human) - FAM98B gene Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). Promotes colorectal cancer cell malignancy (PubMed:28040436). Indicus|evm.model.CM009500.1.450 O95267 GRP1_HUMAN 93.408 0.997516 1.01004 RASGRP1 - RAS guanyl-releasing protein 1 - Homo sapiens (Human) - RASGRP1 gene Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332). Indicus|evm.model.CM009500.1.452 Q28178 TSP1_BOVIN 99.658 0.89854 1.11197 THBS1 - Thrombospondin-1 precursor - Bos taurus (Bovine) - THBS1 gene Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties (By similarity). May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). Indicus|evm.model.CM009500.1.453 Q8NA03 FSIP1_HUMAN 74.570 0.994863 1.00516 FSIP1 - Fibrous sheath-interacting protein 1 - Homo sapiens (Human) - FSIP1 gene Indicus|evm.model.CM009500.1.454 Q14439 GP176_HUMAN 92.621 0.996124 1.00194 GPR176 - G-protein coupled receptor 176 - Homo sapiens (Human) - GPR176 gene Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production. Indicus|evm.model.CM009500.1.455 Q9P2K8 E2AK4_HUMAN 93.598 0.991515 1.00061 EIF2AK4 - eIF-2-alpha kinase GCN2 - Homo sapiens (Human) - EIF2AK4 gene Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). Indicus|evm.model.CM009500.1.456 A6QQL9 SRP14_BOVIN 100.000 0.981982 1.00909 SRP14 - Signal recognition particle 14 kDa protein - Bos taurus (Bovine) - SRP14 gene Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity). Indicus|evm.model.CM009500.1.457 Q96LC9 BMF_HUMAN 92.391 0.831818 1.19565 BMF - Bcl-2-modifying factor - Homo sapiens (Human) - BMF gene May play a role in apoptosis. Isoform 1 seems to be the main initiator. Indicus|evm.model.CM009500.1.458 O60566 BUB1B_HUMAN 88.773 0.98683 1.01238 BUB1B - Mitotic checkpoint serine/threonine-protein kinase BUB1 beta - Homo sapiens (Human) - BUB1B gene Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. Indicus|evm.model.CM009500.1.459 Q5R8Z4 PAK6_PONAB 93.686 0.997067 1.00147 PAK6 - Serine/threonine-protein kinase PAK 6 - Pongo abelii (Sumatran orangutan) - PAK6 gene Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity). Indicus|evm.model.CM009500.1.460 C9JTQ0 ANR63_HUMAN 93.979 0.994778 1.00789 ANKRD63 - Ankyrin repeat domain-containing protein 63 - Homo sapiens (Human) - ANKRD63 gene Indicus|evm.model.CM009500.1.461 Q00722 PLCB2_HUMAN 90.502 0.752733 1.00338 PLCB2 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 - Homo sapiens (Human) - PLCB2 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Indicus|evm.model.CM009500.1.462 P0DMQ5 INAM2_HUMAN 81.699 0.986928 1 INAFM2 - Putative transmembrane protein INAFM2 - Homo sapiens (Human) - INAFM2 gene calcium channel regulator activity Indicus|evm.model.CM009500.1.464 Q5RCJ6 CCD9B_PONAB 70.312 0.996071 0.951402 CCDC9B - Coiled-coil domain-containing protein 9B - Pongo abelii (Sumatran orangutan) - CCDC9B gene Indicus|evm.model.CM009500.1.466 A7MBM2 DISP2_HUMAN 88.150 0.985043 1.00214 DISP2 - Protein dispatched homolog 2 - Homo sapiens (Human) - DISP2 gene plasma membrane, smoothened signaling pathway Indicus|evm.model.CM009500.1.467 Q9Y448 SKAP_HUMAN 82.427 0.991525 0.746835 KNSTRN - Small kinetochore-associated protein - Homo sapiens (Human) - KNSTRN gene Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). Indicus|evm.model.CM009500.1.468 Q3SZI8 IVD_BOVIN 100.000 0.995316 1.00235 IVD - Isovaleryl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - IVD gene Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA. Indicus|evm.model.CM009500.1.469 Q8TBE0 BAHD1_HUMAN 91.037 0.997426 0.996154 BAHD1 - Bromo adjacent homology domain-containing 1 protein - Homo sapiens (Human) - BAHD1 gene Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. Indicus|evm.model.CM009500.1.470 Q8NCH0 CHSTE_HUMAN 93.883 0.994695 1.00266 CHST14 - Carbohydrate sulfotransferase 14 - Homo sapiens (Human) - CHST14 gene Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development. Indicus|evm.model.CM009500.1.471 Q9BV29 CCD32_HUMAN 86.486 0.609589 1.57838 CCDC32 - Coiled-coil domain-containing protein 32 - Homo sapiens (Human) - CCDC32 gene Indicus|evm.model.CM009500.1.472 Q8IZ73 RUSD2_HUMAN 83.946 0.99422 0.952294 RPUSD2 - RNA pseudouridylate synthase domain-containing protein 2 - Homo sapiens (Human) - RPUSD2 gene pseudouridine synthase activity, RNA binding, enzyme-directed rRNA pseudouridine synthesis, mRNA pseudouridine synthesis Indicus|evm.model.CM009500.1.473 Q8NG31 KNL1_HUMAN 69.655 0.999146 1 KNL1 - Kinetochore scaffold 1 - Homo sapiens (Human) - KNL1 gene Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. Indicus|evm.model.CM009500.1.474 Q2KJ94 RAD51_BOVIN 100.000 0.994118 1.00295 RAD51 - DNA repair protein RAD51 homolog 1 - Bos taurus (Bovine) - RAD51 gene Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair. Indicus|evm.model.CM009500.1.475 Q1JQC5 RMD3_BOVIN 100.000 0.995763 1.00212 RMDN3 - Regulator of microtubule dynamics protein 3 - Bos taurus (Bovine) - RMDN3 gene Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity). Indicus|evm.model.CM009500.1.476 Q32L41 GFRP_BOVIN 100.000 0.976471 1.0119 GCHFR - GTP cyclohydrolase 1 feedback regulatory protein - Bos taurus (Bovine) - GCHFR gene Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity). Indicus|evm.model.CM009500.1.477 Q2KI83 DJC17_BOVIN 100.000 0.993443 1.00329 DNAJC17 - DnaJ homolog subfamily C member 17 - Bos taurus (Bovine) - DNAJC17 gene May negatively affect PAX8-induced thyroglobulin/TG transcription. Indicus|evm.model.CM009500.1.478 Q96K21 ANCHR_HUMAN 81.890 0.904762 0.89172 ZFYVE19 - Abscission/NoCut checkpoint regulator - Homo sapiens (Human) - ZFYVE19 gene Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. Indicus|evm.model.CM009500.1.479 Q9NXH3 PP14D_HUMAN 87.586 0.655963 1.50345 PPP1R14D - Protein phosphatase 1 regulatory subunit 14D - Homo sapiens (Human) - PPP1R14D gene Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Indicus|evm.model.CM009500.1.480 O43278 SPIT1_HUMAN 78.450 0.996109 0.971645 SPINT1 - Kunitz-type protease inhibitor 1 precursor - Homo sapiens (Human) - SPINT1 gene Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). Indicus|evm.model.CM009500.1.481 Q17QI8 RHOV_BOVIN 97.110 0.960894 0.758475 Rhov - Rho-related GTP-binding protein RhoV - Bos taurus (Bovine) - Rhov gene Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway. Indicus|evm.model.CM009500.1.482 Q9P253 VPS18_HUMAN 97.122 0.997947 1.00103 VPS18 - Vacuolar protein sorting-associated protein 18 homolog - Homo sapiens (Human) - VPS18 gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). Indicus|evm.model.CM009500.1.483 Q9NR61 DLL4_HUMAN 92.398 0.741585 1.34453 DLL4 - Delta-like protein 4 precursor - Homo sapiens (Human) - DLL4 gene Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). Indicus|evm.model.CM009500.1.484 Q9BUX1 CHAC1_HUMAN 92.342 0.990909 0.990991 CHAC1 - Glutathione-specific gamma-glutamylcyclotransferase 1 - Homo sapiens (Human) - CHAC1 gene Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). Indicus|evm.model.CM009500.1.485 Q9ULG1 INO80_HUMAN 97.126 0.998724 1.00707 INO80 - Chromatin-remodeling ATPase INO80 - Homo sapiens (Human) - INO80 gene ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). Indicus|evm.model.CM009500.1.486 Q5I0H3 SUMO1_RAT 97.030 0.694444 1.42574 Sumo1 - Small ubiquitin-related modifier 1 precursor - Rattus norvegicus (Rat) - Sumo1 gene Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3. Indicus|evm.model.CM009500.1.487 Q8NHP7 EXD1_HUMAN 80.000 0.874126 1.11284 EXD1 - piRNA biogenesis protein EXD1 - Homo sapiens (Human) - EXD1 gene RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity). Indicus|evm.model.CM009500.1.488 Q3SYS6 CHP1_BOVIN 100.000 0.989796 1.00513 CHP1 - Calcineurin B homologous protein 1 - Bos taurus (Bovine) - CHP1 gene Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner (By similarity). Indicus|evm.model.CM009500.1.489 O43482 MS18B_HUMAN 82.412 0.925234 0.934498 OIP5 - Protein Mis18-beta - Homo sapiens (Human) - OIP5 gene Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Indicus|evm.model.CM009500.1.490 Q2YDJ0 NUSAP_BOVIN 99.140 0.99568 0.995699 NUSAP1 - Nucleolar and spindle-associated protein 1 - Bos taurus (Bovine) - NUSAP1 gene Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them (By similarity). Indicus|evm.model.CM009500.1.491 Q0MQ84 CIA30_PANTR 83.232 0.993921 1.00612 NDUFAF1 - Complex I intermediate-associated protein 30, mitochondrial precursor - Pan troglodytes (Chimpanzee) - NDUFAF1 gene Chaperone protein involved in early stages of the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Indicus|evm.model.CM009500.1.492 Q92541 RTF1_HUMAN 98.319 0.997203 1.00704 RTF1 - RNA polymerase-associated protein RTF1 homolog - Homo sapiens (Human) - RTF1 gene Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). Indicus|evm.model.CM009500.1.493 P23677 IP3KA_HUMAN 96.312 0.995671 1.00217 ITPKA - Inositol-trisphosphate 3-kinase A - Homo sapiens (Human) - ITPKA gene cytoplasm, cytosol, nucleus, inositol hexakisphosphate kinase activity, inositol-1,4,5-trisphosphate 3-kinase activity, kinase activity, inositol phosphate biosynthetic process, inositol phosphate metabolic process, phosphatidylinositol phosphorylation, signal transduction Indicus|evm.model.CM009500.1.494 P29376 LTK_HUMAN 78.788 0.385542 0.0960648 LTK - Leukocyte tyrosine kinase receptor precursor - Homo sapiens (Human) - LTK gene Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. Indicus|evm.model.CM009500.1.495 A0JN53 RPAP1_BOVIN 99.570 0.998567 1.00072 RPAP1 - RNA polymerase II-associated protein 1 - Bos taurus (Bovine) - RPAP1 gene Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity). Indicus|evm.model.CM009500.1.496 Q06418 TYRO3_HUMAN 93.018 0.997636 0.950562 TYRO3 - Tyrosine-protein kinase receptor TYRO3 precursor - Homo sapiens (Human) - TYRO3 gene Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Indicus|evm.model.CM009500.1.497 Q96KG9 SCYL1_HUMAN 53.741 0.789474 0.164604 SCYL1 - N-terminal kinase-like protein - Homo sapiens (Human) - SCYL1 gene Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). Has no detectable kinase activity in vitro (PubMed:18556652). Indicus|evm.model.CM009500.1.498 Q8IWI9 MGAP_HUMAN 87.444 0.999358 1.01631 MGA - MAX gene-associated protein - Homo sapiens (Human) - MGA gene Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity). Indicus|evm.model.CM009500.1.499 O60336 MABP1_HUMAN 89.703 0.998007 0.994055 MAPKBP1 - Mitogen-activated protein kinase-binding protein 1 - Homo sapiens (Human) - MAPKBP1 gene Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). Indicus|evm.model.CM009500.1.500 P0C870 JMJD7_HUMAN 93.291 0.285453 3.45886 JMJD7 - Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 - Homo sapiens (Human) - JMJD7 gene Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961, PubMed:29915238). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4 (PubMed:28847961). After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery (PubMed:29915238). Acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (PubMed:29915238). Indicus|evm.model.CM009500.1.501 Q9NRC6 SPTN5_HUMAN 68.316 0.741384 1.03457 SPTBN5 - Spectrin beta chain, non-erythrocytic 5 - Homo sapiens (Human) - SPTBN5 gene cytoplasm, cytosol, membrane, photoreceptor connecting cilium, photoreceptor disc membrane, spectrin, actin binding, dynactin binding, dynein intermediate chain binding, identical protein binding Indicus|evm.model.CM009500.1.502 Q9H223 EHD4_HUMAN 94.640 0.996303 1 EHD4 - EH domain-containing protein 4 - Homo sapiens (Human) - EHD4 gene ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport. Indicus|evm.model.CM009500.1.503 Q3MJ16 PA24E_HUMAN 79.361 0.965217 0.927419 PLA2G4E - Cytosolic phospholipase A2 epsilon - Homo sapiens (Human) - PLA2G4E gene Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:29447909). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide (PubMed:29447909, PubMed:30517655). Has weak phospholipase A2 and lysophospholipase activities (By similarity). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (By similarity). Indicus|evm.model.CM009500.1.504 Q86XP0 PA24D_HUMAN 79.744 0.992298 0.952323 PLA2G4D - Cytosolic phospholipase A2 delta - Homo sapiens (Human) - PLA2G4D gene Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). Has a preference for linoleic acid at the sn-2 position (PubMed:14709560). Indicus|evm.model.CM009500.1.505 Q68DD2 PA24F_HUMAN 82.097 0.997636 0.996466 PLA2G4F - Cytosolic phospholipase A2 zeta - Homo sapiens (Human) - PLA2G4F gene Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256). In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256). Indicus|evm.model.CM009500.1.506 Q96JC1 VPS39_HUMAN 97.178 0.997717 0.988713 VPS39 - Vam6/Vps39-like protein - Homo sapiens (Human) - VPS39 gene Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. Indicus|evm.model.CM009500.1.507 Q8NBN3 TM87A_HUMAN 91.449 0.996516 1.03423 TMEM87A - Transmembrane protein 87A precursor - Homo sapiens (Human) - TMEM87A gene May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). Indicus|evm.model.CM009500.1.508 Q9BE70 GANC_MACFA 87.240 0.838251 1.18986 GANC - Neutral alpha-glucosidase C - Macaca fascicularis (Crab-eating macaque) - GANC gene Has alpha-glucosidase activity. Indicus|evm.model.CM009500.1.509 P51186 CAN3_BOVIN 99.878 0.99757 1.00122 CAPN3 - Calpain-3 - Bos taurus (Bovine) - CAPN3 gene Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53. Indicus|evm.model.CM009500.1.510 Q9H2Y7 ZN106_HUMAN 87.854 0.978992 1.01115 ZNF106 - Zinc finger protein 106 - Homo sapiens (Human) - ZNF106 gene RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. Indicus|evm.model.CM009500.1.511 O09044 SNP23_MOUSE 88.626 0.990566 1.00952 Snap23 - Synaptosomal-associated protein 23 - Mus musculus (Mouse) - Snap23 gene Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. Indicus|evm.model.CM009500.1.512 Q5FVI3 LRC57_RAT 95.816 0.991667 1.00418 Lrrc57 - Leucine-rich repeat-containing protein 57 - Rattus norvegicus (Rat) - Lrrc57 gene Indicus|evm.model.CM009500.1.513 Q9NVX0 HAUS2_HUMAN 85.532 0.991525 1.00426 HAUS2 - HAUS augmin-like complex subunit 2 - Homo sapiens (Human) - HAUS2 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Indicus|evm.model.CM009500.1.514 Q9P2P6 STAR9_HUMAN 90.000 0.0179668 0.935532 STARD9 - StAR-related lipid transfer protein 9 - Homo sapiens (Human) - STARD9 gene Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM). Indicus|evm.model.CM009500.1.515 Q6IQ55 TTBK2_HUMAN 91.667 0.4891 2.02814 TTBK2 - Tau-tubulin kinase 2 - Homo sapiens (Human) - TTBK2 gene Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. Indicus|evm.model.CM009500.1.516 Q8IWV7 UBR1_HUMAN 94.067 0.99886 1.00286 UBR1 - E3 ubiquitin-protein ligase UBR1 - Homo sapiens (Human) - UBR1 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Indicus|evm.model.CM009500.1.517 Q0P6H9 TMM62_HUMAN 83.515 0.996894 1.00156 TMEM62 - Transmembrane protein 62 - Homo sapiens (Human) - TMEM62 gene Indicus|evm.model.CM009500.1.518 Q2KIZ9 CCDB1_BOVIN 100.000 0.994429 1.00279 CCNDBP1 - Cyclin-D1-binding protein 1 - Bos taurus (Bovine) - CCNDBP1 gene May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity). Indicus|evm.model.CM009500.1.519 O46510 EPB42_BOVIN 98.866 0.747029 0.857351 EPB42 - Protein 4.2 - Bos taurus (Bovine) - EPB42 gene Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. Indicus|evm.model.CM009500.1.520 Q5R8Z6 MCFD2_PONAB 94.253 0.817308 0.712329 MCFD2 - Multiple coagulation factor deficiency protein 2 homolog precursor - Pongo abelii (Sumatran orangutan) - MCFD2 gene The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Indicus|evm.model.CM009500.1.521 Q3SYR7 RL9_BOVIN 81.250 0.987578 0.838542 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009500.1.523 Q64152 BTF3_MOUSE 96.491 0.965517 0.284314 Btf3 - Transcription factor BTF3 - Mus musculus (Mouse) - Btf3 gene When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription (By similarity). Indicus|evm.model.CM009500.1.524 Q2TBW8 RL10L_BOVIN 100.000 0.990698 1.00467 RPL10L - 60S ribosomal protein L10-like - Bos taurus (Bovine) - RPL10L gene cytosolic large ribosomal subunit, structural constituent of ribosome, ribosomal large subunit assembly Indicus|evm.model.CM009500.1.525 Q7Z553 MDGA2_HUMAN 99.614 0.943431 0.573222 MDGA2 - MAM domain-containing glycosylphosphatidylinositol anchor protein 2 precursor - Homo sapiens (Human) - MDGA2 gene May be involved in cell-cell interactions. Indicus|evm.model.CM009500.1.531 P43362 MAGA9_HUMAN 51.643 0.8 0.84127 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009500.1.532 P52701 MSH6_HUMAN 62.500 0.27439 0.120588 MSH6 - DNA mismatch repair protein Msh6 - Homo sapiens (Human) - MSH6 gene Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. Indicus|evm.model.CM009500.1.533 P62275 RS29_RAT 97.059 0.170103 3.46429 Rps29 - 40S ribosomal protein S29 - Rattus norvegicus (Rat) - Rps29 gene cytosolic small ribosomal subunit, polysomal ribosome, structural constituent of ribosome, zinc ion binding, cytoplasmic translation, positive regulation of apoptotic process Indicus|evm.model.CM009500.1.534 Q96L50 LLR1_HUMAN 87.736 0.995294 1.02657 LRR1 - Leucine-rich repeat protein 1 - Homo sapiens (Human) - LRR1 gene May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009500.1.535 P83883 RL36A_RAT 100.000 0.981308 1.00943 Rpl36a - 60S ribosomal protein L36a - Rattus norvegicus (Rat) - Rpl36a gene cytosolic large ribosomal subunit, nucleus, response to organic substance, response to retinoic acid Indicus|evm.model.CM009500.1.536 O19071 MGAT2_PIG 93.274 0.995526 1.00224 MGAT2 - Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase - Sus scrofa (Pig) - MGAT2 gene Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans. Indicus|evm.model.CM009500.1.537 Q0VC73 KTU_BOVIN 99.879 0.99759 1.00121 DNAAF2 - Protein kintoun - Bos taurus (Bovine) - DNAAF2 gene Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Indicus|evm.model.CM009500.1.538 A7YWS7 DPOE2_BOVIN 98.102 0.994329 1.0038 POLE2 - DNA polymerase epsilon subunit 2 - Bos taurus (Bovine) - POLE2 gene Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Indicus|evm.model.CM009500.1.539 Q8N7A1 KLDC1_HUMAN 94.335 0.995086 1.00246 KLHDC1 - Kelch domain-containing protein 1 - Homo sapiens (Human) - KLHDC1 gene cytosol Indicus|evm.model.CM009500.1.540 Q5E9A7 KLDC2_BOVIN 100.000 0.995086 1.00246 KLHDC2 - Kelch domain-containing protein 2 - Bos taurus (Bovine) - KLHDC2 gene Represses CREB3-mediated transcription by interfering with CREB3-DNA binding. Indicus|evm.model.CM009500.1.541 O60524 NEMF_HUMAN 93.506 0.998145 1.00186 NEMF - Nuclear export mediator factor NEMF - Homo sapiens (Human) - NEMF gene Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875). Indicus|evm.model.CM009500.1.542 P62332 ARF6_RAT 100.000 0.988636 1.00571 Arf6 - ADP-ribosylation factor 6 - Rattus norvegicus (Rat) - Arf6 gene GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:26446845). Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:16672654). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes (PubMed:26446845). Indicus|evm.model.CM009500.1.543 Q53VB8 FRIL_CANLF 65.476 0.902174 0.525714 FTL - Ferritin light chain - Canis lupus familiaris (Dog) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009500.1.544 Q9H867 MT21D_HUMAN 94.323 0.991304 1.00437 VCPKMT - Protein-lysine methyltransferase METTL21D - Homo sapiens (Human) - VCPKMT gene Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity. Indicus|evm.model.CM009500.1.545 Q07890 SOS2_HUMAN 87.963 0.994475 0.951201 SOS2 - Son of sevenless homolog 2 - Homo sapiens (Human) - SOS2 gene Promotes the exchange of Ras-bound GDP by GTP. Indicus|evm.model.CM009500.1.546 A7MBI3 L2HDH_BOVIN 100.000 0.99569 1.00216 L2HGDH - L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - L2HGDH gene mitochondrion, (S)-2-hydroxy-acid oxidase activity, 2-hydroxyglutarate dehydrogenase activity Indicus|evm.model.CM009500.1.547 P22027 ATP5S_BOVIN 100.000 0.99005 1.005 DMAC2L - ATP synthase subunit s, mitochondrial precursor - Bos taurus (Bovine) - DMAC2L gene Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway. Indicus|evm.model.CM009500.1.548 Q8CEQ0 CDKL1_MOUSE 91.193 0.994334 1.00284 Cdkl1 - Cyclin-dependent kinase-like 1 - Mus musculus (Mouse) - Cdkl1 gene ciliary transition zone, intracellular membrane-bounded organelle, nucleoplasm, nucleus, cyclin-dependent protein serine/threonine kinase activity, protein phosphorylation, regulation of cilium assembly Indicus|evm.model.CM009500.1.550 Q9Y4K4 M4K5_HUMAN 95.260 0.997688 1.02246 MAP4K5 - Mitogen-activated protein kinase kinase kinase kinase 5 - Homo sapiens (Human) - MAP4K5 gene May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Indicus|evm.model.CM009500.1.551 Q58D72 ATLA1_BOVIN 96.325 0.994 0.896057 ATL1 - Atlastin-1 - Bos taurus (Bovine) - ATL1 gene GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Indicus|evm.model.CM009500.1.552 Q9H4B6 SAV1_HUMAN 96.354 0.994805 1.00522 SAV1 - Protein salvador homolog 1 - Homo sapiens (Human) - SAV1 gene Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Indicus|evm.model.CM009500.1.553 Q8N4C6 NIN_HUMAN 86.329 0.948624 1.04306 NIN - Ninein - Homo sapiens (Human) - NIN gene Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). Indicus|evm.model.CM009500.1.555 Q7Z5M8 AB12B_HUMAN 84.320 0.98827 0.941989 ABHD12B - Protein ABHD12B - Homo sapiens (Human) - ABHD12B gene endoplasmic reticulum membrane, membrane, acylglycerol lipase activity, lysophospholipase activity, palmitoyl-(protein) hydrolase activity, monoacylglycerol catabolic process, phosphatidylserine catabolic process Indicus|evm.model.CM009500.1.556 Q0VCM4 PYGL_BOVIN 100.000 0.997653 1.00118 PYGL - Glycogen phosphorylase, liver form - Bos taurus (Bovine) - PYGL gene Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). Indicus|evm.model.CM009500.1.557 Q29RQ5 TRIM9_BOVIN 100.000 0.22096 1.11549 TRIM9 - E3 ubiquitin-protein ligase TRIM9 - Bos taurus (Bovine) - TRIM9 gene E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. Indicus|evm.model.CM009500.1.558 Q0Z7W6 TMX1_BOVIN 99.640 0.992832 1.0036 TMX1 - Thioredoxin-related transmembrane protein 1 precursor - Bos taurus (Bovine) - TMX1 gene May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Indicus|evm.model.CM009500.1.560 Q96NE9 FRMD6_HUMAN 98.553 0.99679 1.00161 FRMD6 - FERM domain-containing protein 6 - Homo sapiens (Human) - FRMD6 gene cytoskeleton, actomyosin structure organization Indicus|evm.model.CM009500.1.561 Q5R7U4 GBG2_PONAB 100.000 0.972222 1.01408 GNG2 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor - Pongo abelii (Sumatran orangutan) - GNG2 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Indicus|evm.model.CM009500.1.562 Q5R8I2 RTRAF_PONAB 97.959 0.99187 1.0082 RTRAF - RNA transcription, translation and transport factor protein - Pongo abelii (Sumatran orangutan) - RTRAF gene RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport. Indicus|evm.model.CM009500.1.563 Q14112 NID2_HUMAN 67.091 0.998469 0.949818 NID2 - Nidogen-2 precursor - Homo sapiens (Human) - NID2 gene Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions. Indicus|evm.model.CM009500.1.564 Q02372 NDUB8_BOVIN 72.464 0.295652 1.23656 NDUFB8 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor - Bos taurus (Bovine) - NDUFB8 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009500.1.565 A5D7K8 PD2R_BOVIN 100.000 0.994475 1.00277 PTGDR - Prostaglandin D2 receptor - Bos taurus (Bovine) - PTGDR gene Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). Indicus|evm.model.CM009500.1.567 Q32LQ1 PKHO2_BOVIN 99.399 0.996 1.002 PLEKHO2 - Pleckstrin homology domain-containing family O member 2 - Bos taurus (Bovine) - PLEKHO2 gene Indicus|evm.model.CM009500.1.568 Q9H611 PIF1_HUMAN 90.172 0.941176 1.06084 PIF1 - ATP-dependent DNA helicase PIF1 - Homo sapiens (Human) - PIF1 gene DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. Indicus|evm.model.CM009500.1.569 Q6ZRY4 RBPS2_HUMAN 96.479 0.566265 1.19139 RBPMS2 - RNA-binding protein with multiple splicing 2 - Homo sapiens (Human) - RBPMS2 gene RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:25064856). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity). Indicus|evm.model.CM009500.1.570 Q5R680 OAZ2_PONAB 100.000 0.712329 1.15873 OAZ2 - Ornithine decarboxylase antizyme 2 - Pongo abelii (Sumatran orangutan) - OAZ2 gene Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (By similarity). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity). Indicus|evm.model.CM009500.1.571 O15014 ZN609_HUMAN 97.251 0.943198 1.01063 ZNF609 - Zinc finger protein 609 - Homo sapiens (Human) - ZNF609 gene Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. Indicus|evm.model.CM009500.1.572 Q15650 TRIP4_HUMAN 87.952 0.994828 0.998279 TRIP4 - Activating signal cointegrator 1 - Homo sapiens (Human) - TRIP4 gene Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). Indicus|evm.model.CM009500.1.573 Q5E9B2 PAF15_BOVIN 100.000 0.982143 1.00901 PCLAF - PCNA-associated factor - Bos taurus (Bovine) - PCLAF gene PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity). Indicus|evm.model.CM009500.1.574 A7E3X2 KC1G1_BOVIN 100.000 0.995633 1.00219 CSNK1G1 - Casein kinase I isoform gamma-1 - Bos taurus (Bovine) - CSNK1G1 gene Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Phosphorylates CLSPN (By similarity). Indicus|evm.model.CM009500.1.575 P80311 PPIB_BOVIN 100.000 0.990783 1.00463 PPIB - Peptidyl-prolyl cis-trans isomerase B precursor - Bos taurus (Bovine) - PPIB gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Indicus|evm.model.CM009500.1.576 Q96L94 SNX22_HUMAN 73.575 0.988506 0.901554 SNX22 - Sorting nexin-22 - Homo sapiens (Human) - SNX22 gene May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). Indicus|evm.model.CM009500.1.577 Q05B62 SNX1_BOVIN 99.617 0.996176 1.00192 SNX1 - Sorting nexin-1 - Bos taurus (Bovine) - SNX1 gene Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity). Indicus|evm.model.CM009500.1.578 Q3T0U7 CIA2A_BOVIN 100.000 0.987578 1.00625 CIAO2A - Cytosolic iron-sulfur assembly component 2A - Bos taurus (Bovine) - CIAO2A gene Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation. May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1. Indicus|evm.model.CM009500.1.579 Q8VDF3 DAPK2_MOUSE 95.278 0.99446 0.975676 Dapk2 - Death-associated protein kinase 2 - Mus musculus (Mouse) - Dapk2 gene Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). Regulates granulocytes motility by controlling cell spreading and polarization (PubMed:24163421). Indicus|evm.model.CM009500.1.581 Q15751 HERC1_HUMAN 98.005 0.999588 0.997737 HERC1 - Probable E3 ubiquitin-protein ligase HERC1 - Homo sapiens (Human) - HERC1 gene Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Indicus|evm.model.CM009500.1.582 Q2HJF2 FXL22_BOVIN 100.000 0.991189 1.00442 FBXL22 - F-box and leucine-rich protein 22 - Bos taurus (Bovine) - FBXL22 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By similarity). Indicus|evm.model.CM009500.1.583 Q9Y6I4 UBP3_HUMAN 97.308 0.996161 1.00192 USP3 - Ubiquitin carboxyl-terminal hydrolase 3 - Homo sapiens (Human) - USP3 gene Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. Indicus|evm.model.CM009500.1.584 O43570 CAH12_HUMAN 77.465 0.994203 0.974576 CA12 - Carbonic anhydrase 12 precursor - Homo sapiens (Human) - CA12 gene Reversible hydration of carbon dioxide. Indicus|evm.model.CM009500.1.585 Q5RDM3 APH1B_PONAB 67.704 0.990783 0.844358 APH1B - Gamma-secretase subunit APH-1B - Pongo abelii (Sumatran orangutan) - APH1B gene Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A (By similarity). Indicus|evm.model.CM009500.1.586 Q2HJI8 RAB8B_BOVIN 99.517 0.990385 1.00483 RAB8B - Ras-related protein Rab-8B precursor - Bos taurus (Bovine) - RAB8B gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). Indicus|evm.model.CM009500.1.587 Q3T0B7 RS27L_BOVIN 100.000 0.642857 1.5 RPS27L - 40S ribosomal protein S27-like - Bos taurus (Bovine) - RPS27L gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, ribosomal small subunit assembly Indicus|evm.model.CM009500.1.588 P83095 LACTB_BOVIN 99.460 0.996409 1.0018 LACTB - Serine beta-lactamase-like protein LACTB, mitochondrial precursor - Bos taurus (Bovine) - LACTB gene Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Indicus|evm.model.CM009500.1.589 P67937 TPM4_PIG 82.258 0.991968 1.00403 TPM4 - Tropomyosin alpha-4 chain - Sus scrofa (Pig) - TPM4 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. Indicus|evm.model.CM009500.1.590 P58773 TPM1_COTJA 58.730 0.796178 0.552817 TPM1 - Tropomyosin alpha-1 chain - Coturnix japonica (Japanese quail) - TPM1 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Indicus|evm.model.CM009500.1.591 Q9Y4G6 TLN2_HUMAN 98.938 0.999214 1.00039 TLN2 - Talin-2 - Homo sapiens (Human) - TLN2 gene As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). Indicus|evm.model.CM009500.1.594 Q2KJ18 C2C4A_BOVIN 100.000 0.994521 1.00275 C2CD4A - C2 calcium-dependent domain-containing protein 4A - Bos taurus (Bovine) - C2CD4A gene May be involved in inflammatory process. May regulate cell architecture and adhesion (By similarity). Indicus|evm.model.CM009500.1.595 Q2KJ18 C2C4A_BOVIN 75.000 0.809896 1.05495 C2CD4A - C2 calcium-dependent domain-containing protein 4A - Bos taurus (Bovine) - C2CD4A gene May be involved in inflammatory process. May regulate cell architecture and adhesion (By similarity). Indicus|evm.model.CM009500.1.596 Q709C8 VP13C_HUMAN 86.182 0.999461 0.988809 VPS13C - Vacuolar protein sorting-associated protein 13C - Homo sapiens (Human) - VPS13C gene Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization. Indicus|evm.model.CM009500.1.597 P35398 RORA_HUMAN 99.782 0.974414 0.89675 RORA - Nuclear receptor ROR-alpha - Homo sapiens (Human) - RORA gene Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development (PubMed:29656859). Regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC1 and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling. Indicus|evm.model.CM009500.1.599 Q0VCQ7 ICE2_BOVIN 99.898 0.997963 1.00102 ICE2 - Little elongation complex subunit 2 - Bos taurus (Bovine) - ICE2 gene Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Indicus|evm.model.CM009500.1.600 A2SW69 ANXA2_SHEEP 100.000 0.994118 1.00295 ANXA2 - Annexin A2 - Ovis aries (Sheep) - ANXA2 gene Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Indicus|evm.model.CM009500.1.601 Q99853 FOXB1_HUMAN 99.692 0.993865 1.00308 FOXB1 - Forkhead box protein B1 - Homo sapiens (Human) - FOXB1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, anatomical structure morphogenesis, axon target recognition, cell differentiation, cell migration in diencephalon Indicus|evm.model.CM009500.1.603 Q12982 BNIP2_HUMAN 94.785 0.740319 1.39809 BNIP2 - BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 - Homo sapiens (Human) - BNIP2 gene Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins. Indicus|evm.model.CM009500.1.604 P52657 T2AG_HUMAN 100.000 0.981818 1.00917 GTF2A2 - Transcription initiation factor IIA subunit 2 - Homo sapiens (Human) - GTF2A2 gene TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. Indicus|evm.model.CM009500.1.605 Q7YQE1 GCNT3_BOVIN 100.000 0.995465 1.00227 GCNT3 - Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 - Bos taurus (Bovine) - GCNT3 gene Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. Indicus|evm.model.CM009500.1.606 Q3UXZ6 FA81A_MOUSE 94.678 0.994413 0.983516 Fam81a - Protein FAM81A - Mus musculus (Mouse) - Fam81a gene Indicus|evm.model.CM009500.1.607 Q12965 MYO1E_HUMAN 95.126 0.998197 1.0009 MYO1E - Unconventional myosin-Ie - Homo sapiens (Human) - MYO1E gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. Indicus|evm.model.CM009500.1.608 O77689 CCNB2_BOVIN 100.000 0.994987 1.00251 CCNB2 - G2/mitotic-specific cyclin-B2 - Bos taurus (Bovine) - CCNB2 gene Essential for the control of the cell cycle at the G2/M (mitosis) transition. Indicus|evm.model.CM009500.1.609 Q6ZNA4 RN111_HUMAN 95.779 0.99799 1.00101 RNF111 - E3 ubiquitin-protein ligase Arkadia - Homo sapiens (Human) - RNF111 gene E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity). Indicus|evm.model.CM009500.1.610 Q8CH25 SLTM_MOUSE 90.987 0.481366 0.936954 Sltm - SAFB-like transcription modulator - Mus musculus (Mouse) - Sltm gene When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. Indicus|evm.model.CM009500.1.611 Q2KI23 MINY2_BOVIN 99.525 0.99684 1.00476 MINDY2 - Ubiquitin carboxyl-terminal hydrolase MINDY-2 - Bos taurus (Bovine) - MINDY2 gene Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Can also bind to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33' and 'Lys-63'. May play a regulatory role at the level of protein turnover. Indicus|evm.model.CM009500.1.612 Q10741 ADA10_BOVIN 100.000 0.99733 1.00134 ADAM10 - Disintegrin and metalloproteinase domain-containing protein 10 precursor - Bos taurus (Bovine) - ADAM10 gene Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:10097139). Contributes to the normal cleavage of the cellular prion protein (By similarity). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (By similarity). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (By similarity). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (By similarity). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (By similarity). Indicus|evm.model.CM009500.1.613 P27656 LIPC_MOUSE 72.807 0.484009 0.919608 Lipc - Hepatic triacylglycerol lipase precursor - Mus musculus (Mouse) - Lipc gene Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (By similarity). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (By similarity). Indicus|evm.model.CM009500.1.614 P35521 ICLN_CANLF 90.295 0.991597 1.01277 CLNS1A - Methylosome subunit pICln - Canis lupus familiaris (Dog) - CLNS1A gene Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway (By similarity). Indicus|evm.model.CM009500.1.615 O43315 AQP9_HUMAN 82.712 0.993243 1.00339 AQP9 - Aquaporin-9 - Homo sapiens (Human) - AQP9 gene Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines. Indicus|evm.model.CM009500.1.617 O94788 AL1A2_HUMAN 99.228 0.996146 1.00193 ALDH1A2 - Retinal dehydrogenase 2 - Homo sapiens (Human) - ALDH1A2 gene Converts retinaldehyde to retinoic acid (PubMed:29240402). Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral (By similarity). Indicus|evm.model.CM009500.1.618 Q17QE3 GRL1A_BOVIN 99.189 0.994595 1 POLR2M - DNA-directed RNA polymerase II subunit GRINL1A - Bos taurus (Bovine) - POLR2M gene Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in Mediator complex-dependent regulation of transcription activation. Acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. Indicus|evm.model.CM009500.1.619 P0CAP1 MYZAP_HUMAN 91.202 0.99569 0.995708 MYZAP - Myocardial zonula adherens protein precursor - Homo sapiens (Human) - MYZAP gene Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). Indicus|evm.model.CM009500.1.620 Q0VF96 CGNL1_HUMAN 86.339 0.998454 0.993856 CGNL1 - Cingulin-like protein 1 - Homo sapiens (Human) - CGNL1 gene May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. Indicus|evm.model.CM009500.1.622 Q60420 HTF4_MESAU 96.092 0.808194 1.22883 TCF12 - Transcription factor 12 - Mesocricetus auratus (Golden hamster) - TCF12 gene Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Participates in the control of inducible RP4 gene expression in salivary cells (By similarity). Binds to the RIPE3 element of the insulin II promoter. Indicus|evm.model.CM009500.1.623 Q99081 HTF4_HUMAN 97.207 0.927083 0.281525 TCF12 - Transcription factor 12 - Homo sapiens (Human) - TCF12 gene Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Indicus|evm.model.CM009500.1.625 Q6N043 Z280D_HUMAN 88.235 0.983454 0.987743 ZNF280D - Zinc finger protein 280D - Homo sapiens (Human) - ZNF280D gene May function as a transcription factor. Indicus|evm.model.CM009500.1.626 Q2KIQ2 MNS1_BOVIN 98.182 0.99596 1 MNS1 - Meiosis-specific nuclear structural protein 1 - Bos taurus (Bovine) - MNS1 gene May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis (By similarity). Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (By similarity). Indicus|evm.model.CM009500.1.627 Q8N6V9 TEX9_HUMAN 84.655 0.994832 0.98977 TEX9 - Testis-expressed protein 9 - Homo sapiens (Human) - TEX9 gene Indicus|evm.model.CM009500.1.628 Q2KHR2 RFX7_HUMAN 91.422 0.931154 1.05503 RFX7 - DNA-binding protein RFX7 - Homo sapiens (Human) - RFX7 gene chromatin, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009500.1.629 P46934 NEDD4_HUMAN 95.771 0.890244 0.683851 NEDD4 - E3 ubiquitin-protein ligase NEDD4 - Homo sapiens (Human) - NEDD4 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Indicus|evm.model.CM009500.1.631 Q2VWP7 PRTG_HUMAN 88.253 0.915254 0.872174 PRTG - Protogenin precursor - Homo sapiens (Human) - PRTG gene May play a role in anteroposterior axis elongation. Indicus|evm.model.CM009500.1.632 Q9Y3Y4 PYGO1_HUMAN 94.586 0.993651 0.75179 PYGO1 - Pygopus homolog 1 - Homo sapiens (Human) - PYGO1 gene Involved in signal transduction through the Wnt pathway. Indicus|evm.model.CM009500.1.633 Q863A4 DAAF4_PONPY 88.810 0.992891 1.00476 DNAAF4 - Dynein axonemal assembly factor 4 - Pongo pygmaeus (Bornean orangutan) - DNAAF4 gene Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility (By similarity). Indicus|evm.model.CM009500.1.634 Q5R6R3 CCPG1_PONAB 82.971 0.962917 1.00372 CCPG1 - Cell cycle progression protein 1 - Pongo abelii (Sumatran orangutan) - CCPG1 gene Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation (By similarity). Indicus|evm.model.CM009500.1.635 Q1LZA0 PIGB_BOVIN 85.952 0.995851 0.890943 PIGB - GPI mannosyltransferase 3 - Bos taurus (Bovine) - PIGB gene Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity). Indicus|evm.model.CM009500.1.637 Q4LE85 RB27A_PIG 96.380 0.990991 1.00452 RAB27A - Ras-related protein Rab-27A - Sus scrofa (Pig) - RAB27A gene Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Indicus|evm.model.CM009500.1.638 Q3SZ12 RLP24_BOVIN 100.000 0.81407 1.22086 RSL24D1 - Probable ribosome biogenesis protein RLP24 - Bos taurus (Bovine) - RSL24D1 gene Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity). Indicus|evm.model.CM009500.1.640 Q8NB66 UN13C_HUMAN 89.569 0.994012 0.452575 UNC13C - Protein unc-13 homolog C - Homo sapiens (Human) - UNC13C gene May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity). Indicus|evm.model.CM009500.1.641 Q3MJ13 WDR72_HUMAN 87.980 0.982323 0.359347 WDR72 - WD repeat-containing protein 72 - Homo sapiens (Human) - WDR72 gene Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. Indicus|evm.model.CM009500.1.643 Q3MJ13 WDR72_HUMAN 82.090 0.985075 0.0607985 WDR72 - WD repeat-containing protein 72 - Homo sapiens (Human) - WDR72 gene Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. Indicus|evm.model.CM009500.1.644 Q5RFQ4 WDR72_PONAB 76.515 0.877778 0.409836 WDR72 - WD repeat-containing protein 72 - Pongo abelii (Sumatran orangutan) - WDR72 gene Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. Indicus|evm.model.CM009500.1.645 P15927 RFA2_HUMAN 91.935 0.984 0.462963 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Indicus|evm.model.CM009500.1.646 Q5RAY5 RBM22_PONAB 67.984 0.826415 0.630952 RBM22 - Pre-mRNA-splicing factor RBM22 - Pongo abelii (Sumatran orangutan) - RBM22 gene Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. Indicus|evm.model.CM009500.1.647 Q9UBC0 HNF6_HUMAN 98.925 0.995708 1.00215 ONECUT1 - Hepatocyte nuclear factor 6 - Homo sapiens (Human) - ONECUT1 gene Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Indicus|evm.model.CM009500.1.649 Q32MH5 F214A_HUMAN 84.298 0.998163 1.01208 FAM214A - Protein FAM214A - Homo sapiens (Human) - FAM214A gene Indicus|evm.model.CM009500.1.650 Q28055 ARP19_BOVIN 100.000 0.982301 1.00893 ARPP19 - cAMP-regulated phosphoprotein 19 - Bos taurus (Bovine) - ARPP19 gene Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression (By similarity). Indicus|evm.model.CM009500.1.651 Q9Y4I1 MYO5A_HUMAN 97.185 0.952947 1.04259 MYO5A - Unconventional myosin-Va - Homo sapiens (Human) - MYO5A gene Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. Indicus|evm.model.CM009500.1.652 Q9NQX4 MYO5C_HUMAN 93.966 0.359627 0.924225 MYO5C - Unconventional myosin-Vc - Homo sapiens (Human) - MYO5C gene May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues. Indicus|evm.model.CM009500.1.653 Q80ZD0 GNB5_TAMST 99.433 0.99435 1.00283 GNB5 - Guanine nucleotide-binding protein subunit beta-5 - Tamias striatus (Eastern chipmunk) - GNB5 gene Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). Indicus|evm.model.CM009500.1.654 Q9HD36 B2L10_HUMAN 54.902 0.761905 0.926471 BCL2L10 - Bcl-2-like protein 10 - Homo sapiens (Human) - BCL2L10 gene Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11689480, PubMed:11278245). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). Indicus|evm.model.CM009500.1.655 Q2T9N1 F1142_BOVIN 91.304 0.135802 0.324 FAM114A1 - Protein FAM114A2 - Bos taurus (Bovine) - FAM114A1 gene Indicus|evm.model.CM009500.1.656 Q16659 MK06_HUMAN 97.645 0.997234 1.00277 MAPK6 - Mitogen-activated protein kinase 6 - Homo sapiens (Human) - MAPK6 gene Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). Indicus|evm.model.CM009500.1.657 Q8WVC0 LEO1_HUMAN 97.156 0.99701 1.0045 LEO1 - RNA polymerase-associated protein LEO1 - Homo sapiens (Human) - LEO1 gene Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. Indicus|evm.model.CM009500.1.658 Q5XJE5 LEO1_MOUSE 64.506 0.936364 0.494753 Leo1 - RNA polymerase-associated protein LEO1 - Mus musculus (Mouse) - Leo1 gene Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling (By similarity). Indicus|evm.model.CM009500.1.659 Q9NYL9 TMOD3_HUMAN 94.393 0.954955 0.315341 TMOD3 - Tropomodulin-3 - Homo sapiens (Human) - TMOD3 gene Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Indicus|evm.model.CM009500.1.660 Q9NYL9 TMOD3_HUMAN 96.842 0.696296 0.383523 TMOD3 - Tropomodulin-3 - Homo sapiens (Human) - TMOD3 gene Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Indicus|evm.model.CM009500.1.661 Q9NZR1 TMOD2_HUMAN 97.151 0.855746 1.16524 TMOD2 - Tropomodulin-2 - Homo sapiens (Human) - TMOD2 gene Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Indicus|evm.model.CM009500.1.662 Q1JQA8 LYSM2_BOVIN 100.000 0.990741 1.00465 LYSMD2 - LysM and putative peptidoglycan-binding domain-containing protein 2 - Bos taurus (Bovine) - LYSMD2 gene Indicus|evm.model.CM009500.1.663 A6QLI2 SCG3_BOVIN 99.788 0.995763 1.00212 SCG3 - Secretogranin-3 precursor - Bos taurus (Bovine) - SCG3 gene Member of the granin protein family that regulates the biogenesis of secretory granules (By similarity). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity). Indicus|evm.model.CM009500.1.664 Q8TDJ6 DMXL2_HUMAN 97.521 0.0401741 0.98386 DMXL2 - DmX-like protein 2 - Homo sapiens (Human) - DMXL2 gene May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). Indicus|evm.model.CM009500.1.665 Q921F2 TADBP_MOUSE 81.522 0.947917 0.231884 Tardbp - TAR DNA-binding protein 43 - Mus musculus (Mouse) - Tardbp gene RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (By similarity). Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (By similarity). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). Indicus|evm.model.CM009500.1.666 Q6ZMI3 GLDN_HUMAN 88.989 0.996377 1.00181 GLDN - Gliomedin precursor - Homo sapiens (Human) - GLDN gene Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. Indicus|evm.model.CM009500.1.667 P46194 CP19A_BOVIN 99.795 0.99591 0.972167 CYP19A1 - Aromatase - Bos taurus (Bovine) - CYP19A1 gene A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.CM009500.1.668 P79304 CP193_PIG 91.525 0.568627 0.203593 CYP19A3 - Aromatase 3 - Sus scrofa (Pig) - CYP19A3 gene Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Indicus|evm.model.CM009500.1.669 P46194 CP19A_BOVIN 58.031 0.984962 0.264414 CYP19A1 - Aromatase - Bos taurus (Bovine) - CYP19A1 gene A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.CM009500.1.670 Q5GJ75 TP8L3_HUMAN 94.241 0.984456 0.660959 TNFAIP8L3 - Tumor necrosis factor alpha-induced protein 8-like protein 3 - Homo sapiens (Human) - TNFAIP8L3 gene Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling. Indicus|evm.model.CM009500.1.671 Q9UPM8 AP4E1_HUMAN 89.592 0.998267 1.01495 AP4E1 - AP-4 complex subunit epsilon-1 - Homo sapiens (Human) - AP4E1 gene Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). Indicus|evm.model.CM009500.1.672 Q8TCT8 SPP2A_HUMAN 88.740 0.996183 1.00769 SPPL2A - Signal peptide peptidase-like 2A precursor - Homo sapiens (Human) - SPPL2A gene Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). Indicus|evm.model.CM009500.1.673 Q96QT4 TRPM7_HUMAN 96.195 0.998929 1.00107 TRPM7 - Transient receptor potential cation channel subfamily M member 7 - Homo sapiens (Human) - TRPM7 gene Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). Indicus|evm.model.CM009500.1.674 Q4R6D3 UBP50_MACFA 86.022 0.973615 1.01609 USP50 - Putative ubiquitin carboxyl-terminal hydrolase 50 - Macaca fascicularis (Crab-eating macaque) - USP50 gene May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Indicus|evm.model.CM009500.1.675 P40818 UBP8_HUMAN 88.014 0.998158 0.971377 USP8 - Ubiquitin carboxyl-terminal hydrolase 8 - Homo sapiens (Human) - USP8 gene Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). Indicus|evm.model.CM009500.1.677 Q06547 GABP1_HUMAN 100.000 0.987805 0.622785 GABPB1 - GA-binding protein subunit beta-1 - Homo sapiens (Human) - GABPB1 gene Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:8441384, PubMed:10675337, PubMed:8816484). Acts as a a master regulator of nuclear-encoded mitochondrial genes (By similarity). Indicus|evm.model.CM009500.1.678 Q5EA83 DCHS_BOVIN 100.000 0.996965 1.00152 HDC - Histidine decarboxylase - Bos taurus (Bovine) - HDC gene Catalyzes the biosynthesis of histamine from histidine. Indicus|evm.model.CM009500.1.679 Q06547 GABP1_HUMAN 100.000 0.955696 0.4 GABPB1 - GA-binding protein subunit beta-1 - Homo sapiens (Human) - GABPB1 gene Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:8441384, PubMed:10675337, PubMed:8816484). Acts as a a master regulator of nuclear-encoded mitochondrial genes (By similarity). Indicus|evm.model.CM009500.1.680 A0A075B6T8 TVA91_HUMAN 75.294 0.743363 1.00893 TRAV9-1 - T cell receptor alpha variable 9-1 precursor - Homo sapiens (Human) - TRAV9-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.681 A0A0B4J235 TVAM2_HUMAN 61.165 0.682759 1.28319 TRAV13-2 - T cell receptor alpha variable 13-2 precursor - Homo sapiens (Human) - TRAV13-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Indicus|evm.model.CM009500.1.682 O14975 S27A2_HUMAN 85.484 0.996779 1.00161 SLC27A2 - Very long-chain acyl-CoA synthetase - Homo sapiens (Human) - SLC27A2 gene Acyl CoA synthetase that activates long-chain and very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed:10198260, PubMed:10749848, PubMed:11980911). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake (PubMed:20530735). Indicus|evm.model.CM009500.1.683 Q8TF62 AT8B4_HUMAN 93.078 0.732548 0.925336 ATP8B4 - Probable phospholipid-transporting ATPase IM - Homo sapiens (Human) - ATP8B4 gene Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Indicus|evm.model.CM009500.1.684 Q8N5C7 DTWD1_HUMAN 87.500 0.993377 0.993421 DTWD1 - tRNA-uridine aminocarboxypropyltransferase 1 - Homo sapiens (Human) - DTWD1 gene Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)). Indicus|evm.model.CM009500.1.685 Q96M60 F227B_HUMAN 68.258 0.988827 0.704724 FAM227B - Protein FAM227B - Homo sapiens (Human) - FAM227B gene Indicus|evm.model.CM009500.1.686 P79150 FGF7_CANLF 100.000 0.979592 0.505155 FGF7 - Fibroblast growth factor 7 precursor - Canis lupus familiaris (Dog) - FGF7 gene Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity). Indicus|evm.model.CM009500.1.687 Q01415 GALK2_HUMAN 93.886 0.995643 1.00218 GALK2 - N-acetylgalactosamine kinase - Homo sapiens (Human) - GALK2 gene Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. Indicus|evm.model.CM009500.1.688 P61203 CSN2_RAT 100.000 0.995495 1.00226 Cops2 - COP9 signalosome complex subunit 2 - Rattus norvegicus (Rat) - Cops2 gene Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Indicus|evm.model.CM009500.1.689 Q93073 SBP2L_HUMAN 95.082 0.115607 0.47139 SECISBP2L - Selenocysteine insertion sequence-binding protein 2-like - Homo sapiens (Human) - SECISBP2L gene Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro. Indicus|evm.model.CM009500.1.690 Q93073 SBP2L_HUMAN 89.401 0.972973 0.201635 SECISBP2L - Selenocysteine insertion sequence-binding protein 2-like - Homo sapiens (Human) - SECISBP2L gene Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro. Indicus|evm.model.CM009500.1.691 Q6S5L8 SHC4_HUMAN 86.667 0.996737 0.973016 SHC4 - SHC-transforming protein 4 - Homo sapiens (Human) - SHC4 gene Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. Indicus|evm.model.CM009500.1.692 O94986 CE152_HUMAN 74.442 0.998878 1.04211 CEP152 - Centrosomal protein of 152 kDa - Homo sapiens (Human) - CEP152 gene Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). Indicus|evm.model.CM009500.1.693 P98133 FBN1_BOVIN 100.000 0.971893 1.02856 FBN1 - Fibrillin-1 precursor - Bos taurus (Bovine) - FBN1 gene Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function. Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils. Indicus|evm.model.CM009500.1.694 P33316 DUT_HUMAN 90.566 0.849462 0.738095 DUT - Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor - Homo sapiens (Human) - DUT gene This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Indicus|evm.model.CM009500.1.695 P55015 S12A1_RABIT 96.000 0.998182 1.00091 SLC12A1 - Solute carrier family 12 member 1 - Oryctolagus cuniculus (Rabbit) - SLC12A1 gene Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. Indicus|evm.model.CM009500.1.696 Q9P2K5 MYEF2_HUMAN 96.000 0.996672 1.00167 MYEF2 - Myelin expression factor 2 - Homo sapiens (Human) - MYEF2 gene Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). Indicus|evm.model.CM009500.1.697 Q71RS6 NCKX5_HUMAN 90.600 0.994024 1.004 SLC24A5 - Sodium/potassium/calcium exchanger 5 precursor - Homo sapiens (Human) - SLC24A5 gene Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Indicus|evm.model.CM009500.1.698 Q8NFY4 SEM6D_HUMAN 96.041 0.99816 1.01305 SEMA6D - Semaphorin-6D precursor - Homo sapiens (Human) - SEMA6D gene Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Indicus|evm.model.CM009500.1.700 E2RK33 GATC_CANLF 60.000 0.982759 0.374194 GATC - Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial precursor - Canis lupus familiaris (Dog) - GATC gene Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Indicus|evm.model.CM009500.1.701 Q9Y6N5 SQOR_HUMAN 91.556 0.995565 1.00222 SQOR - Sulfide:quinone oxidoreductase, mitochondrial precursor - Homo sapiens (Human) - SQOR gene Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro) (PubMed:22852582). It is believed the in vivo electron acceptor is glutathione (PubMed:25225291,PubMed:29715001). Indicus|evm.model.CM009500.1.702 Q08DU8 BL1S6_BOVIN 100.000 0.988439 1.00581 BLOC1S6 - Biogenesis of lysosome-related organelles complex 1 subunit 6 - Bos taurus (Bovine) - BLOC1S6 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process (By similarity). Indicus|evm.model.CM009500.1.703 O14863 ZNT4_HUMAN 94.393 0.993023 1.00233 SLC30A4 - Zinc transporter 4 - Homo sapiens (Human) - SLC30A4 gene Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment. Indicus|evm.model.CM009500.1.704 Q9C002 NMES1_HUMAN 83.099 0.636364 1.3253 NMES1 - Normal mucosa of esophagus-specific gene 1 protein - Homo sapiens (Human) - NMES1 gene mitochondrial respiratory chain complex IV, nucleus Indicus|evm.model.CM009500.1.705 A7YSY2 SPA5L_BOVIN 100.000 0.997396 1.0013 SPATA5L1 - Spermatogenesis-associated protein 5-like protein 1 - Bos taurus (Bovine) - SPATA5L1 gene cytoplasm, spindle, ATPase activity Indicus|evm.model.CM009500.1.706 Q2HJ74 GATM_BOVIN 100.000 0.995283 1.00236 GATM - Glycine amidinotransferase, mitochondrial precursor - Bos taurus (Bovine) - GATM gene Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). Indicus|evm.model.CM009500.1.707 O43868 S28A2_HUMAN 85.714 0.995455 1.00304 SLC28A2 - Sodium/nucleoside cotransporter 2 - Homo sapiens (Human) - SLC28A2 gene Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues. Indicus|evm.model.CM009500.1.708 Q7M4L6 SHF_HUMAN 83.333 0.890736 0.995272 SHF - SH2 domain-containing adapter protein F - Homo sapiens (Human) - SHF gene Adapter protein which may play a role in the regulation of apoptosis in response to PDGF. Indicus|evm.model.CM009500.1.709 Q8HZK3 DUOX1_PIG 93.883 0.998713 1.00064 DUOX1 - Dual oxidase 1 precursor - Sus scrofa (Pig) - DUOX1 gene Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Indicus|evm.model.CM009500.1.710 Q1HG43 DOXA1_HUMAN 84.840 0.994083 0.985423 DUOXA1 - Dual oxidase maturation factor 1 - Homo sapiens (Human) - DUOXA1 gene May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1. Indicus|evm.model.CM009500.1.711 Q1HG44 DOXA2_HUMAN 78.816 0.993769 1.00313 DUOXA2 - Dual oxidase maturation factor 2 - Homo sapiens (Human) - DUOXA2 gene Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis. Indicus|evm.model.CM009500.1.712 Q8HZK2 DUOX2_PIG 89.709 0.998706 1.00065 DUOX2 - Dual oxidase 2 precursor - Sus scrofa (Pig) - DUOX2 gene Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Indicus|evm.model.CM009500.1.713 Q58D31 DHSO_BOVIN 100.000 0.994398 1.00281 SORD - Sorbitol dehydrogenase - Bos taurus (Bovine) - SORD gene Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with xylitol, D-sorbitol (D-glucitol) and L-iditol as substrates, leading to the C2-oxidized products D-xylulose, D-fructose and L-sorbose, respectively (PubMed:9143345). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). Cannot use NADP(+) as the electron acceptor. Has no activity on ethanol, methanol, glycerol, galactitol and fructose 6-phosphate (PubMed:9143345). Indicus|evm.model.CM009500.1.714 Q8N5G0 SIM20_HUMAN 94.595 0.4 1.34328 SMIM20 - Small integral membrane protein 20 - Homo sapiens (Human) - SMIM20 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (PubMed:26321642). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (PubMed:26321642). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (PubMed:26321642). Indicus|evm.model.CM009500.1.715 Q9ULW0 TPX2_HUMAN 60.127 0.756219 0.269076 TPX2 - Targeting protein for Xklp2 - Homo sapiens (Human) - TPX2 gene Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940). Indicus|evm.model.CM009500.1.716 Q5RCP8 H2B2E_PONAB 91.270 0.984127 1 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009500.1.717 Q96AC1 FERM2_HUMAN 98.263 0.947802 1.07059 FERMT2 - Fermitin family homolog 2 - Homo sapiens (Human) - FERMT2 gene Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. Indicus|evm.model.CM009500.1.718 O46606 DDHD1_BOVIN 99.771 0.997717 1.00114 DDHD1 - Phospholipase DDHD1 - Bos taurus (Bovine) - DDHD1 gene Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid (PubMed:9488669). Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). Indicus|evm.model.CM009500.1.720 Q2KJH1 BMP4_BOVIN 99.756 0.625767 1.59413 BMP4 - Bone morphogenetic protein 4 precursor - Bos taurus (Bovine) - BMP4 gene Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (By similarity). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity). Indicus|evm.model.CM009500.1.721 Q9MYN5 CDKN3_PIG 96.226 0.99061 1.00472 CDKN3 - Cyclin-dependent kinase inhibitor 3 - Sus scrofa (Pig) - CDKN3 gene May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity). Indicus|evm.model.CM009500.1.722 O35372 CNIH1_MOUSE 100.000 0.986207 1.00694 Cnih1 - Protein cornichon homolog 1 - Mus musculus (Mouse) - Cnih1 gene Involved in the selective transport and maturation of TGF-alpha family proteins. Indicus|evm.model.CM009500.1.724 Q5R6P6 GMFB_PONAB 87.117 0.987805 1.15493 GMFB - Glia maturation factor beta - Pongo abelii (Sumatran orangutan) - GMFB gene This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. Indicus|evm.model.CM009500.1.725 Q99675 CGRF1_HUMAN 96.386 0.993994 1.00301 CGRRF1 - Cell growth regulator with RING finger domain protein 1 - Homo sapiens (Human) - CGRRF1 gene Able to inhibit growth in several cell lines. Indicus|evm.model.CM009500.1.726 Q9UPU9 SMAG1_HUMAN 97.350 0.997214 1 SAMD4A - Protein Smaug homolog 1 - Homo sapiens (Human) - SAMD4A gene Acts as a translational repressor of SRE-containing messengers. Indicus|evm.model.CM009500.1.727 P45478 PPT1_BOVIN 60.839 0.955224 0.437908 PPT1 - Palmitoyl-protein thioesterase 1 precursor - Bos taurus (Bovine) - PPT1 gene Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. Indicus|evm.model.CM009500.1.728 Q5E984 TCTP_BOVIN 98.990 0.98 0.581395 TPT1 - Translationally-controlled tumor protein - Bos taurus (Bovine) - TPT1 gene Involved in calcium binding and microtubule stabilization. Indicus|evm.model.CM009500.1.729 P30793 GCH1_HUMAN 91.600 0.992 1 GCH1 - GTP cyclohydrolase 1 - Homo sapiens (Human) - GCH1 gene Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Indicus|evm.model.CM009500.1.730 O75717 WDHD1_HUMAN 88.594 0.998227 0.999114 WDHD1 - WD repeat and HMG-box DNA-binding protein 1 - Homo sapiens (Human) - WDHD1 gene Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Indicus|evm.model.CM009500.1.731 Q0VC91 SOCS4_BOVIN 100.000 0.995465 1.00227 SOCS4 - Suppressor of cytokine signaling 4 - Bos taurus (Bovine) - SOCS4 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity). Indicus|evm.model.CM009500.1.732 Q5E9L3 MISSL_BOVIN 100.000 0.875458 1.1375 MAPK1IP1L - MAPK-interacting and spindle-stabilizing protein-like - Bos taurus (Bovine) - MAPK1IP1L gene Indicus|evm.model.CM009500.1.733 P62752 RL23A_RAT 71.591 0.851485 0.647436 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009500.1.734 P16110 LEG3_MOUSE 81.273 0.992481 1.00758 Lgals3 - Galectin-3 - Mus musculus (Mouse) - Lgals3 gene Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. Indicus|evm.model.CM009500.1.735 Q15398 DLGP5_HUMAN 77.160 0.987013 1.00118 DLGAP5 - Disks large-associated protein 5 - Homo sapiens (Human) - DLGAP5 gene Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. Indicus|evm.model.CM009500.1.736 Q9NWN3 FBX34_HUMAN 84.572 0.997199 1.00422 FBXO34 - F-box only protein 34 - Homo sapiens (Human) - FBXO34 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009500.1.737 Q6ZNE5 BAKOR_HUMAN 95.732 0.995943 1.00203 ATG14 - Beclin 1-associated autophagy-related key regulator - Homo sapiens (Human) - ATG14 gene Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity). Indicus|evm.model.CM009500.1.738 Q92117 TBP_PROFL 88.265 0.570175 1.14 TBP - TATA-box-binding protein - Protobothrops flavoviridis (Habu) - TBP gene General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Indicus|evm.model.CM009500.1.740 Q86UP2 KTN1_HUMAN 92.631 0.998527 1.00074 KTN1 - Kinectin - Homo sapiens (Human) - KTN1 gene Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. Indicus|evm.model.CM009500.1.741 Q9HAT8 PELI2_HUMAN 98.810 0.995249 1.00238 PELI2 - E3 ubiquitin-protein ligase pellino homolog 2 - Homo sapiens (Human) - PELI2 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Indicus|evm.model.CM009500.1.742 Q9NX78 TM260_HUMAN 84.006 0.982327 0.960396 TMEM260 - Transmembrane protein 260 - Homo sapiens (Human) - TMEM260 gene Indicus|evm.model.CM009500.1.743 P32243 OTX2_HUMAN 98.962 0.993103 1.00346 OTX2 - Homeobox protein OTX2 - Homo sapiens (Human) - OTX2 gene Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'. Indicus|evm.model.CM009500.1.744 P68370 TBA1A_RAT 75.227 0.963145 0.902439 Tuba1a - Tubulin alpha-1A chain - Rattus norvegicus (Rat) - Tuba1a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009500.1.745 O00471 EXOC5_HUMAN 91.757 0.997245 1.02542 EXOC5 - Exocyst complex component 5 - Homo sapiens (Human) - EXOC5 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Indicus|evm.model.CM009500.1.746 Q5E9X5 AP5M1_BOVIN 99.796 0.995927 1.00204 AP5M1 - AP-5 complex subunit mu-1 - Bos taurus (Bovine) - AP5M1 gene As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. Indicus|evm.model.CM009500.1.747 Q147X3 NAA30_HUMAN 92.011 0.994444 0.994475 NAA30 - N-alpha-acetyltransferase 30 - Homo sapiens (Human) - NAA30 gene Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate. Indicus|evm.model.CM009500.1.748 Q9NVL8 CC198_HUMAN 68.367 0.992481 0.898649 CCDC198 - Uncharacterized protein CCDC198 - Homo sapiens (Human) - CCDC198 gene Indicus|evm.model.CM009500.1.749 Q8BZK4 S35F4_MOUSE 95.778 0.929607 0.995876 Slc35f4 - Solute carrier family 35 member F4 - Mus musculus (Mouse) - Slc35f4 gene Putative solute transporter. Indicus|evm.model.CM009500.1.750 Q2TA21 ARMD4_BOVIN 100.000 0.915254 0.232895 ARMH4 - Armadillo-like helical domain-containing protein 4 precursor - Bos taurus (Bovine) - ARMH4 gene Indicus|evm.model.CM009500.1.751 Q2TA21 ARMD4_BOVIN 100.000 0.75827 1.03421 ARMH4 - Armadillo-like helical domain-containing protein 4 precursor - Bos taurus (Bovine) - ARMH4 gene Indicus|evm.model.CM009500.1.752 Q3ZBD2 ARP10_BOVIN 100.000 0.995215 1.0024 ACTR10 - Actin-related protein 10 - Bos taurus (Bovine) - ACTR10 gene dynactin complex, microtubule-based movement, retrograde axonal transport of mitochondrion Indicus|evm.model.CM009500.1.753 Q58DU5 PSA3_BOVIN 100.000 0.992188 1.00392 PSMA3 - Proteasome subunit alpha type-3 - Bos taurus (Bovine) - PSMA3 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. Indicus|evm.model.CM009500.1.754 P29374 ARI4A_HUMAN 93.185 0.998415 1.00398 ARID4A - AT-rich interactive domain-containing protein 4A - Homo sapiens (Human) - ARID4A gene DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). Indicus|evm.model.CM009500.1.755 Q9Y5J7 TIM9_HUMAN 100.000 0.977778 1.01124 TIMM9 - Mitochondrial import inner membrane translocase subunit Tim9 - Homo sapiens (Human) - TIMM9 gene Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Indicus|evm.model.CM009500.1.756 Q9BVV6 TALD3_HUMAN 79.186 0.977128 1.02674 KIAA0586 - Protein TALPID3 - Homo sapiens (Human) - KIAA0586 gene Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). Indicus|evm.model.CM009500.1.757 Q8R4A3 DACT1_MOUSE 90.090 0.172144 0.821337 Dact1 - Dapper homolog 1 - Mus musculus (Mouse) - Dact1 gene Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB (By similarity). Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway. The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling (By similarity). May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. Indicus|evm.model.CM009500.1.759 Q9Y4D1 DAAM1_HUMAN 97.681 0.998129 0.991651 DAAM1 - Disheveled-associated activator of morphogenesis 1 - Homo sapiens (Human) - DAAM1 gene Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). Indicus|evm.model.CM009500.1.760 Q8IZ08 GP135_HUMAN 86.631 0.994638 0.755061 GPR135 - G-protein coupled receptor 135 - Homo sapiens (Human) - GPR135 gene Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). Indicus|evm.model.CM009500.1.761 Q3SX04 T3HPD_BOVIN 100.000 0.994366 1.00282 L3HYPDH - Trans-L-3-hydroxyproline dehydratase - Bos taurus (Bovine) - L3HYPDH gene Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Indicus|evm.model.CM009500.1.762 Q9P055 JKAMP_HUMAN 98.071 0.99359 1.00322 JKAMP - JNK1/MAPK8-associated membrane protein - Homo sapiens (Human) - JKAMP gene May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity). Indicus|evm.model.CM009500.1.763 Q2T9Z6 CC175_BOVIN 99.860 0.88806 1.1105 CCDC175 - Coiled-coil domain-containing protein 175 - Bos taurus (Bovine) - CCDC175 gene Indicus|evm.model.CM009500.1.764 Q5IS59 RTN1_PANTR 86.340 0.997426 1.00129 RTN1 - Reticulon-1 - Pan troglodytes (Chimpanzee) - RTN1 gene Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. Indicus|evm.model.CM009500.1.765 Q6ZRR7 LRRC9_HUMAN 89.902 0.959596 1.02202 LRRC9 - Leucine-rich repeat-containing protein 9 - Homo sapiens (Human) - LRRC9 gene Indicus|evm.model.CM009500.1.767 Q63HM2 PCX4_HUMAN 82.925 0.99746 1.00768 PCNX4 - Pecanex-like protein 4 - Homo sapiens (Human) - PCNX4 gene Indicus|evm.model.CM009500.1.768 Q9Y394 DHRS7_HUMAN 85.619 0.805405 1.09145 DHRS7 - Dehydrogenase/reductase SDR family member 7 precursor - Homo sapiens (Human) - DHRS7 gene membrane Indicus|evm.model.CM009500.1.769 O62829 PPM1A_BOVIN 100.000 0.994778 1.00262 PPM1A - Protein phosphatase 1A - Bos taurus (Bovine) - PPM1A gene Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). Indicus|evm.model.CM009500.1.770 Q8N1H7 S6OS1_HUMAN 75.944 0.795527 1.06644 SIX6OS1 - Protein SIX6OS1 - Homo sapiens (Human) - SIX6OS1 gene Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination. Required for the appropriate processing of intermediate recombination nodules before crossover formation. Indicus|evm.model.CM009500.1.772 O95475 SIX6_HUMAN 97.967 0.991903 1.00407 SIX6 - Homeobox protein SIX6 - Homo sapiens (Human) - SIX6 gene May be involved in eye development. Indicus|evm.model.CM009500.1.773 A2D5H2 SIX1_LAGLA 98.944 0.992982 1.00352 SIX1 - Homeobox protein SIX1 - Lagothrix lagotricha (Brown woolly monkey) - SIX1 gene Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (By similarity). Plays an important role in the development of several organs, including kidney, muscle and inner ear (By similarity). Depending on context, functions as transcriptional repressor or activator (By similarity). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (By similarity). Mediates nuclear translocation of EYA1 and EYA2 (By similarity). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (By similarity). Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR (By similarity). Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2 (By similarity). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1 (By similarity). Promotes brown adipocyte differentiation (By similarity). Indicus|evm.model.CM009500.1.776 Q5R538 FRIL_PONAB 80.851 0.605263 0.434286 FTL - Ferritin light chain - Pongo abelii (Sumatran orangutan) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009500.1.777 Q9UIU6 SIX4_HUMAN 91.968 0.965049 0.659411 SIX4 - Homeobox protein SIX4 - Homo sapiens (Human) - SIX4 gene Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. Indicus|evm.model.CM009500.1.778 P51948 MAT1_HUMAN 97.735 0.993548 1.00324 MNAT1 - CDK-activating kinase assembly factor MAT1 - Homo sapiens (Human) - MNAT1 gene Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Indicus|evm.model.CM009500.1.779 Q3MHN8 TRM5_BOVIN 99.799 0.995984 1.00201 TRMT5 - tRNA (guanine(37)-N1)-methyltransferase - Bos taurus (Bovine) - TRMT5 gene Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Indicus|evm.model.CM009500.1.780 Q8IZM9 S38A6_HUMAN 88.816 0.995624 1.00219 SLC38A6 - Probable sodium-coupled neutral amino acid transporter 6 - Homo sapiens (Human) - SLC38A6 gene Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate. Indicus|evm.model.CM009500.1.781 P05786 K2C8_BOVIN 97.490 0.995825 1.00209 KRT8 - Keratin, type II cytoskeletal 8 - Bos taurus (Bovine) - KRT8 gene Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Indicus|evm.model.CM009500.1.782 Q3MIR4 CC50B_HUMAN 95.322 0.963277 1.00855 TMEM30B - Cell cycle control protein 50B - Homo sapiens (Human) - TMEM30B gene Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane. Indicus|evm.model.CM009500.1.783 P24723 KPCL_HUMAN 98.807 0.998296 0.859444 PRKCH - Protein kinase C eta type - Homo sapiens (Human) - PRKCH gene Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. Indicus|evm.model.CM009500.1.785 Q9XTA5 HIF1A_BOVIN 99.878 0.997573 1.00122 HIF1A - Hypoxia-inducible factor 1-alpha - Bos taurus (Bovine) - HIF1A gene Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (By similarity). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with NCOA1 and/or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). Indicus|evm.model.CM009500.1.786 Q16533 SNPC1_HUMAN 82.385 0.983871 1.01087 SNAPC1 - snRNA-activating protein complex subunit 1 - Homo sapiens (Human) - SNAPC1 gene Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. Indicus|evm.model.CM009500.1.787 Q17RD7 SYT16_HUMAN 88.960 0.725309 1.00465 SYT16 - Synaptotagmin-16 - Homo sapiens (Human) - SYT16 gene May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. Indicus|evm.model.CM009500.1.788 A6QPD8 U730_BOVIN 100.000 0.285714 3.43137 Putative UPF0730 protein encoded by LINC00643 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009500.1.790 Q8NCM2 KCNH5_HUMAN 99.089 0.997978 1.00101 KCNH5 - Potassium voltage-gated channel subfamily H member 5 - Homo sapiens (Human) - KCNH5 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Indicus|evm.model.CM009500.1.791 Q9H4E5 RHOJ_HUMAN 95.794 0.990698 1.00467 RHOJ - Rho-related GTP-binding protein RhoJ precursor - Homo sapiens (Human) - RHOJ gene Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707). Indicus|evm.model.CM009500.1.792 Q86YW7 GPHB5_HUMAN 91.538 0.984733 1.00769 GPHB5 - Glycoprotein hormone beta-5 precursor - Homo sapiens (Human) - GPHB5 gene Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. Indicus|evm.model.CM009500.1.793 O70374 MTG8R_MOUSE 88.830 0.989418 0.318182 Cbfa2t2 - Protein CBFA2T2 - Mus musculus (Mouse) - Cbfa2t2 gene Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation (PubMed:27281218). Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent mannerCan repress the expression of MMP7 in a ZBTB33-dependent manner (By similarity). Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:19799863). Required for the maintenance of the secretory cell lineage in the small intestine (PubMed:16227606). Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (PubMed:25398765). Indicus|evm.model.CM009500.1.794 O43439 MTG8R_HUMAN 88.393 0.770035 0.475166 CBFA2T2 - Protein CBFA2T2 - Homo sapiens (Human) - CBFA2T2 gene Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). Indicus|evm.model.CM009500.1.795 Q16537 2A5E_HUMAN 100.000 0.995726 1.00214 PPP2R5E - Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform - Homo sapiens (Human) - PPP2R5E gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Indicus|evm.model.CM009500.1.796 Q3ZBK1 WDR89_BOVIN 99.741 0.994832 1.00259 WDR89 - WD repeat-containing protein 89 - Bos taurus (Bovine) - WDR89 gene Indicus|evm.model.CM009500.1.797 Q9BX95 SGPP1_HUMAN 78.652 0.995192 0.943311 SGPP1 - Sphingosine-1-phosphate phosphatase 1 - Homo sapiens (Human) - SGPP1 gene Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:12815058, PubMed:11756451, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic retiulum to the Golgi apparatus (PubMed:16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:20798685, PubMed:18583713). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity). Indicus|evm.model.CM009500.1.798 Q8WXH0 SYNE2_HUMAN 81.948 0.999633 0.791285 SYNE2 - Nesprin-2 - Homo sapiens (Human) - SYNE2 gene Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Indicus|evm.model.CM009500.1.799 Q9XSB5 ESR2_BOVIN 91.651 0.99596 0.939279 ESR2 - Estrogen receptor beta - Bos taurus (Bovine) - ESR2 gene Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Indicus|evm.model.CM009500.1.801 P11586 C1TC_HUMAN 92.513 0.997863 1.00107 MTHFD1 - C-1-tetrahydrofolate synthase, cytoplasmic - Homo sapiens (Human) - MTHFD1 gene cytosol, extracellular exosome, membrane, mitochondrion, formate-tetrahydrofolate ligase activity, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity, 10-formyltetrahydrofolate biosynthetic process Indicus|evm.model.CM009500.1.802 P24275 AKAP5_BOVIN 99.299 0.995338 1.00234 AKAP5 - A-kinase anchor protein 5 - Bos taurus (Bovine) - AKAP5 gene Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses. Indicus|evm.model.CM009500.1.803 A1YEX3 ZBT25_GORGO 95.225 0.959184 0.901149 ZBTB25 - Zinc finger and BTB domain-containing protein 25 - Gorilla gorilla gorilla (Western lowland gorilla) - ZBTB25 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009500.1.804 Q9Y2K1 ZBTB1_HUMAN 97.896 0.997199 1.0014 ZBTB1 - Zinc finger and BTB domain-containing protein 1 - Homo sapiens (Human) - ZBTB1 gene Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). Indicus|evm.model.CM009500.1.805 P34933 HSP72_BOVIN 99.843 0.99686 1.00157 HSPA2 - Heat shock-related 70 kDa protein 2 - Bos taurus (Bovine) - HSPA2 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells. Indicus|evm.model.CM009500.1.806 Q96LQ0 PPR36_HUMAN 77.251 0.995062 0.959716 PPP1R36 - Protein phosphatase 1 regulatory subunit 36 - Homo sapiens (Human) - PPP1R36 gene Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Indicus|evm.model.CM009500.1.807 A1L390 PKHG3_HUMAN 85.470 0.350943 1.08696 PLEKHG3 - Pleckstrin homology domain-containing family G member 3 - Homo sapiens (Human) - PLEKHG3 gene Indicus|evm.model.CM009500.1.808 P11277 SPTB1_HUMAN 91.356 0.891397 1.09874 SPTB - Spectrin beta chain, erythrocytic - Homo sapiens (Human) - SPTB gene Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Indicus|evm.model.CM009500.1.809 Q2HJG7 CHUR_BOVIN 100.000 0.985714 1.00719 CHURC1 - Protein Churchill - Bos taurus (Bovine) - CHURC1 gene Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement. Does not bind DNA by itself (By similarity). Indicus|evm.model.CM009500.1.810 Q9JHC0 GPX2_MOUSE 94.118 0.861314 0.721053 Gpx2 - Glutathione peroxidase 2 - Mus musculus (Mouse) - Gpx2 gene cytosol, glutathione peroxidase activity, peroxidase activity, biological process involved in interaction with symbiont, negative regulation of inflammatory response to antigenic stimulus, response to symbiotic bacterium, temperature homeostasis Indicus|evm.model.CM009500.1.811 Q1RMR4 RAB15_BOVIN 99.528 0.99061 1.00472 RAB15 - Ras-related protein Rab-15 - Bos taurus (Bovine) - RAB15 gene May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal. EHBP1L1. Indicus|evm.model.CM009500.1.812 P49355 FNTB_BOVIN 100.000 0.995434 1.00229 FNTB - Protein farnesyltransferase subunit beta - Bos taurus (Bovine) - FNTB gene Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X (By similarity). Indicus|evm.model.CM009500.1.813 P61244 MAX_HUMAN 99.375 0.987578 1.00625 MAX - Protein max - Homo sapiens (Human) - MAX gene Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. Indicus|evm.model.CM009500.1.814 Q9N0W2 FUT8_BOVIN 99.304 0.996528 1.00174 FUT8 - Alpha-(1,6)-fucosyltransferase - Bos taurus (Bovine) - FUT8 gene Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Indicus|evm.model.CM009500.1.815 Q3T014 PMGE_BOVIN 96.911 0.992308 1.00386 BPGM - Bisphosphoglycerate mutase - Bos taurus (Bovine) - BPGM gene Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. Indicus|evm.model.CM009500.1.816 Q2YDE5 CC196_BOVIN 99.415 0.57047 1.50505 CCDC196 - Putative coiled-coil domain-containing protein 196 - Bos taurus (Bovine) - CCDC196 gene Indicus|evm.model.CM009500.1.818 Q2YDE8 FA71D_BOVIN 99.744 0.944175 1.03778 FAM71D - Protein FAM71D - Bos taurus (Bovine) - FAM71D gene Indicus|evm.model.CM009500.1.819 E2QY99 MPP5_CANLF 98.815 0.997041 1.00148 PALS1 - Protein PALS1 - Canis lupus familiaris (Dog) - PALS1 gene Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:17182851). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (PubMed:17182851). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). May play a role in the T-cell receptor-mediated activation of NF-kappa-B (By similarity). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). Indicus|evm.model.CM009500.1.820 P39942 VATD_BOVIN 99.595 0.991935 1.00405 ATP6V1D - V-type proton ATPase subunit D - Bos taurus (Bovine) - ATP6V1D gene Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). Indicus|evm.model.CM009500.1.821 P68101 IF2A_RAT 100.000 0.993671 1.00317 Eif2s1 - Eukaryotic translation initiation factor 2 subunit 1 - Rattus norvegicus (Rat) - Eif2s1 gene Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. Indicus|evm.model.CM009500.1.822 Q9NYT0 PLEK2_HUMAN 94.334 0.99435 1.00283 PLEK2 - Pleckstrin-2 - Homo sapiens (Human) - PLEK2 gene May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. Indicus|evm.model.CM009500.1.823 Q5EA70 T229B_BOVIN 100.000 0.988095 1.00599 TMEM229B - Transmembrane protein 229B - Bos taurus (Bovine) - TMEM229B gene Indicus|evm.model.CM009500.1.825 Q9ULM0 PKHH1_HUMAN 86.813 0.998529 0.997067 PLEKHH1 - Pleckstrin homology domain-containing family H member 1 - Homo sapiens (Human) - PLEKHH1 gene Indicus|evm.model.CM009500.1.826 Q32L89 PIGH_BOVIN 98.936 0.939698 1.05851 PIGH - Phosphatidylinositol N-acetylglucosaminyltransferase subunit H - Bos taurus (Bovine) - PIGH gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Indicus|evm.model.CM009500.1.827 Q58DL1 ARGI2_BOVIN 99.718 0.994366 1.00282 ARG2 - Arginase-2, mitochondrial precursor - Bos taurus (Bovine) - ARG2 gene May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity. Indicus|evm.model.CM009500.1.828 Q2KIU0 VTI1B_BOVIN 99.569 0.991416 1.00431 VTI1B - Vesicle transport through interaction with t-SNAREs homolog 1B - Bos taurus (Bovine) - VTI1B gene V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. Indicus|evm.model.CM009500.1.829 Q8TC12 RDH11_HUMAN 89.109 0.88563 1.07233 RDH11 - Retinol dehydrogenase 11 - Homo sapiens (Human) - RDH11 gene Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956). Indicus|evm.model.CM009500.1.830 P59837 RDH12_BOVIN 98.980 0.811634 1.14241 RDH12 - Retinol dehydrogenase 12 - Bos taurus (Bovine) - RDH12 gene Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids. Indicus|evm.model.CM009500.1.831 Q4SUE2 TMA7_TETNG 59.524 0.533333 1.17188 tma7 - Translation machinery-associated protein 7 - Tetraodon nigroviridis (Spotted green pufferfish) - tma7 gene Indicus|evm.model.CM009500.1.832 E1BLZ4 ZFY26_BOVIN 98.659 0.99921 1.00676 ZFYVE26 - Zinc finger FYVE domain-containing protein 26 - Bos taurus (Bovine) - ZFYVE26 gene Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity). Indicus|evm.model.CM009500.1.833 O15315 RA51B_HUMAN 82.370 0.980769 0.8125 RAD51B - DNA repair protein RAD51 homolog 2 - Homo sapiens (Human) - RAD51B gene Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Indicus|evm.model.CM009500.1.835 Q07352 TISB_HUMAN 99.112 0.9941 1.00296 ZFP36L1 - mRNA decay activator protein ZFP36L1 - Homo sapiens (Human) - ZFP36L1 gene Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity). Indicus|evm.model.CM009500.1.836 Q3B7N2 ACTN1_BOVIN 97.593 0.997814 1.02578 ACTN1 - Alpha-actinin-1 - Bos taurus (Bovine) - ACTN1 gene F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). Indicus|evm.model.CM009500.1.837 Q96JK2 DCAF5_HUMAN 92.486 0.997691 0.919321 DCAF5 - DDB1- and CUL4-associated factor 5 - Homo sapiens (Human) - DCAF5 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Indicus|evm.model.CM009500.1.838 Q9NVH0 EXD2_HUMAN 89.776 0.993631 1.01127 EXD2 - Exonuclease 3'-5' domain-containing protein 2 - Homo sapiens (Human) - EXD2 gene Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). Indicus|evm.model.CM009500.1.840 Q8N428 GLT16_HUMAN 93.728 0.996416 1 GALNT16 - Polypeptide N-acetylgalactosaminyltransferase 16 - Homo sapiens (Human) - GALNT16 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Indicus|evm.model.CM009500.1.841 P84089 ERH_MOUSE 100.000 0.980952 1.00962 Erh - Enhancer of rudimentary homolog - Mus musculus (Mouse) - Erh gene May have a role in the cell cycle. Indicus|evm.model.CM009500.1.843 Q9NUM3 S39A9_HUMAN 95.440 0.993506 1.00326 SLC39A9 - Zinc transporter ZIP9 - Homo sapiens (Human) - SLC39A9 gene May act as a zinc-influx transporter. Indicus|evm.model.CM009500.1.844 A6NEE1 PLHD1_HUMAN 91.700 0.99596 0.978261 PLEKHD1 - Pleckstrin homology domain-containing family D member 1 - Homo sapiens (Human) - PLEKHD1 gene Indicus|evm.model.CM009500.1.845 Q3UHB8 CC177_MOUSE 90.842 0.389127 0.990085 Ccdc177 - Coiled-coil domain-containing protein 177 - Mus musculus (Mouse) - Ccdc177 gene Indicus|evm.model.CM009500.1.846 Q92537 SUSD6_HUMAN 91.749 0.993355 0.993399 SUSD6 - Sushi domain-containing protein 6 precursor - Homo sapiens (Human) - SUSD6 gene May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity). Indicus|evm.model.CM009500.1.847 Q13243 SRSF5_HUMAN 98.540 0.992674 1.00368 SRSF5 - Serine/arginine-rich splicing factor 5 - Homo sapiens (Human) - SRSF5 gene Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Indicus|evm.model.CM009500.1.848 Q14973 NTCP_HUMAN 83.478 0.927224 1.06304 SLC10A1 - Sodium/bile acid cotransporter - Homo sapiens (Human) - SLC10A1 gene The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Indicus|evm.model.CM009500.1.849 Q9H4F8 SMOC1_HUMAN 96.092 0.995413 1.00461 SMOC1 - SPARC-related modular calcium-binding protein 1 precursor - Homo sapiens (Human) - SMOC1 gene Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation. Indicus|evm.model.CM009500.1.850 S4R2P9 NAC3_MOUSE 85.271 0.964377 0.423491 Slc8a3 - Sodium/calcium exchanger 3 precursor - Mus musculus (Mouse) - Slc8a3 gene Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain (PubMed:14722618, PubMed:21593315). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:14722618, PubMed:21593315). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:14722618). In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (PubMed:21593315). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (PubMed:24616101). Isoform 1 displays higher calcium exchanger activity than isoform 2, probably because isoform 1 has a lower threshold for activation by cytoplasmic Ca(2+) (PubMed:24616101). Indicus|evm.model.CM009500.1.851 Q6UWI4 SHSA2_HUMAN 54.000 0.842593 0.366102 SHISA2 - Protein shisa-2 homolog precursor - Homo sapiens (Human) - SHISA2 gene Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Indicus|evm.model.CM009500.1.852 P57103 NAC3_HUMAN 97.143 0.996644 0.642934 SLC8A3 - Sodium/calcium exchanger 3 precursor - Homo sapiens (Human) - SLC8A3 gene Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity). Indicus|evm.model.CM009500.1.853 Q3T0C9 SYJ2B_BOVIN 100.000 0.986301 1.0069 SYNJ2BP - Synaptojanin-2-binding protein - Bos taurus (Bovine) - SYNJ2BP gene Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. Indicus|evm.model.CM009500.1.854 Q2NKS2 COX16_BOVIN 100.000 0.981481 1.00935 COX16 - Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial - Bos taurus (Bovine) - COX16 gene Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6. Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines. Indicus|evm.model.CM009500.1.856 Q9UKJ8 ADA21_HUMAN 73.826 0.968144 1 ADAM21 - Disintegrin and metalloproteinase domain-containing protein 21 precursor - Homo sapiens (Human) - ADAM21 gene May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. Indicus|evm.model.CM009500.1.857 O43506 ADA20_HUMAN 70.554 0.899604 1.0427 ADAM20 - Disintegrin and metalloproteinase domain-containing protein 20 precursor - Homo sapiens (Human) - ADAM20 gene May be involved in sperm maturation and/or fertilization. Indicus|evm.model.CM009500.1.858 Q3SZY9 MED6_BOVIN 100.000 0.991903 1.00407 MED6 - Mediator of RNA polymerase II transcription subunit 6 - Bos taurus (Bovine) - MED6 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009500.1.859 Q92623 TTC9A_HUMAN 96.078 0.968153 0.707207 TTC9 - Tetratricopeptide repeat protein 9A - Homo sapiens (Human) - TTC9 gene Indicus|evm.model.CM009500.1.860 P80192 M3K9_HUMAN 96.290 0.998188 1 MAP3K9 - Mitogen-activated protein kinase kinase kinase 9 - Homo sapiens (Human) - MAP3K9 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Indicus|evm.model.CM009500.1.861 Q96RV3 PCX1_HUMAN 96.657 0.649561 0.923964 PCNX1 - Pecanex-like protein 1 - Homo sapiens (Human) - PCNX1 gene Indicus|evm.model.CM009500.1.862 Q58DT1 RL7_BOVIN 89.919 0.991416 0.939516 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Indicus|evm.model.CM009500.1.864 P35979 RL12_MOUSE 100.000 0.627027 1.12121 Rpl12 - 60S ribosomal protein L12 - Mus musculus (Mouse) - Rpl12 gene Binds directly to 26S ribosomal RNA. Indicus|evm.model.CM009500.1.865 O43166 SI1L1_HUMAN 96.898 0.998893 1.00111 SIPA1L1 - Signal-induced proliferation-associated 1-like protein 1 - Homo sapiens (Human) - SIPA1L1 gene Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). Indicus|evm.model.CM009500.1.866 P49758 RGS6_HUMAN 94.082 0.995927 1.04025 RGS6 - Regulator of G-protein signaling 6 - Homo sapiens (Human) - RGS6 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). Indicus|evm.model.CM009500.1.867 Q92784 DPF3_HUMAN 97.354 0.994723 1.00265 DPF3 - Zinc finger protein DPF3 - Homo sapiens (Human) - DPF3 gene Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. Indicus|evm.model.CM009500.1.868 Q5R938 RS15A_PONAB 97.692 0.984733 1.00769 RPS15A - 40S ribosomal protein S15a - Pongo abelii (Sumatran orangutan) - RPS15A gene Structural component of the ribosome. Required for proper erythropoiesis. Indicus|evm.model.CM009500.1.869 Q58DC2 DCAF4_BOVIN 98.583 0.99596 1.00202 DCAF4 - DDB1- and CUL4-associated factor 4 - Bos taurus (Bovine) - DCAF4 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Indicus|evm.model.CM009500.1.870 Q810J8 ZFYV1_MOUSE 96.525 0.997429 1.00129 Zfyve1 - Zinc finger FYVE domain-containing protein 1 - Mus musculus (Mouse) - Zfyve1 gene Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contact sites by forming a complex with RAB18 and ZW10 (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (By similarity). Indicus|evm.model.CM009500.1.871 P49756 RBM25_HUMAN 99.881 0.99763 1.00119 RBM25 - RNA-binding protein 25 - Homo sapiens (Human) - RBM25 gene RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. Indicus|evm.model.CM009500.1.872 Q9XT97 PSN1_BOVIN 97.699 0.886148 1.10251 PSEN1 - Presenilin-1 - Bos taurus (Bovine) - PSEN1 gene Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (By similarity). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis. Involved in the regulation of neurite outgrowth (By similarity). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). Indicus|evm.model.CM009500.1.874 O95428 PPN_HUMAN 74.842 0.980328 0.954617 PAPLN - Papilin precursor - Homo sapiens (Human) - PAPLN gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization Indicus|evm.model.CM009500.1.875 P49757 NUMB_HUMAN 88.055 0.996764 0.949309 NUMB - Protein numb homolog - Homo sapiens (Human) - NUMB gene Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). Indicus|evm.model.CM009500.1.876 Q86WZ0 HEAT4_HUMAN 75.522 0.971872 1.00487 HEATR4 - HEAT repeat-containing protein 4 - Homo sapiens (Human) - HEATR4 gene oxidoreductase activity Indicus|evm.model.CM009500.1.877 Q86TX2 ACOT1_HUMAN 83.610 0.903226 1.10451 ACOT1 - Acyl-coenzyme A thioesterase 1 - Homo sapiens (Human) - ACOT1 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20). Indicus|evm.model.CM009500.1.878 Q8N9L9 ACOT4_HUMAN 82.892 0.974118 1.0095 ACOT4 - Peroxisomal succinyl-coenzyme A thioesterase - Homo sapiens (Human) - ACOT4 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). ACOT4 is a peroxisomal succinyl-coenzyme A thioesterase can also hydrolyze glutaryl-CoA and long chain saturated acyl-CoAs (PubMed:16940157). Indicus|evm.model.CM009500.1.879 Q86TX2 ACOT1_HUMAN 81.235 0.995261 1.00238 ACOT1 - Acyl-coenzyme A thioesterase 1 - Homo sapiens (Human) - ACOT1 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20). Indicus|evm.model.CM009500.1.880 Q5VVW2 GARL3_HUMAN 85.448 0.747899 0.352419 GARNL3 - GTPase-activating Rap/Ran-GAP domain-like protein 3 - Homo sapiens (Human) - GARNL3 gene cytoplasm, GTPase activator activity, activation of GTPase activity Indicus|evm.model.CM009500.1.881 Q8N9L9 ACOT4_HUMAN 83.133 0.992806 0.990499 ACOT4 - Peroxisomal succinyl-coenzyme A thioesterase - Homo sapiens (Human) - ACOT4 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). ACOT4 is a peroxisomal succinyl-coenzyme A thioesterase can also hydrolyze glutaryl-CoA and long chain saturated acyl-CoAs (PubMed:16940157). Indicus|evm.model.CM009500.1.882 Q32Q92 ACOT6_MOUSE 72.986 0.995261 1.00716 Acot6 - Acyl-coenzyme A thioesterase 6 - Mus musculus (Mouse) - Acot6 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:17613526). Acyl-coenzyme A thioesterase 6/ACOT6 catalyzes the hydrolysis of phytanoyl-CoA and pristanoyl-CoA, two methyl-branched fatty acids derived from phytol, that enter the body via the diet (PubMed:17613526). Indicus|evm.model.CM009500.1.883 Q02543 RL18A_HUMAN 91.477 0.988166 0.960227 RPL18A - 60S ribosomal protein L18a - Homo sapiens (Human) - RPL18A gene cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing Indicus|evm.model.CM009500.1.884 Q2KID4 DNAL1_BOVIN 100.000 0.989529 1.00526 DNAL1 - Dynein axonemal light chain 1 - Bos taurus (Bovine) - DNAL1 gene Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (By similarity). Indicus|evm.model.CM009500.1.885 A6QLK5 PNMA1_BOVIN 100.000 0.99435 1.00283 PNMA1 - Paraneoplastic antigen Ma1 homolog - Bos taurus (Bovine) - PNMA1 gene cytoplasm, nucleolus, inflammatory response to antigenic stimulus Indicus|evm.model.CM009500.1.886 Q6PJG2 MDEAS_HUMAN 89.184 0.945554 1.05455 MIDEAS - Mitotic deacetylase-associated SANT domain protein - Homo sapiens (Human) - MIDEAS gene histone deacetylase complex, nucleoplasm, transcription regulator complex, transcription corepressor activity, histone deacetylation, negative regulation of transcription, DNA-templated, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009500.1.887 Q32L99 PTGR2_BOVIN 100.000 0.994318 1.00285 PTGR2 - Prostaglandin reductase 2 - Bos taurus (Bovine) - PTGR2 gene Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Indicus|evm.model.CM009500.1.888 Q5EAC5 ZN410_BOVIN 97.490 0.995825 1.0257 ZNF410 - Zinc finger protein 410 - Bos taurus (Bovine) - ZNF410 gene Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. Indicus|evm.model.CM009500.1.889 Q96MY7 F161B_HUMAN 76.923 0.996928 1.00618 FAM161B - Protein FAM161B - Homo sapiens (Human) - FAM161B gene cytoplasmic microtubule, microtubule cytoskeleton, cilium organization Indicus|evm.model.CM009500.1.890 Q2KIL4 COQ6_BOVIN 99.574 0.995745 1.00213 COQ6 - Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial precursor - Bos taurus (Bovine) - COQ6 gene FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. Indicus|evm.model.CM009500.1.891 E1BPW0 ENTP5_BOVIN 98.843 0.995338 0.993056 ENTPD5 - Ectonucleoside triphosphate diphosphohydrolase 5 precursor - Bos taurus (Bovine) - ENTPD5 gene Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling (By similarity). Indicus|evm.model.CM009500.1.892 Q8ND07 BBOF1_HUMAN 81.621 0.928309 1.02836 BBOF1 - Basal body-orientation factor 1 - Homo sapiens (Human) - BBOF1 gene Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity). Indicus|evm.model.CM009500.1.893 Q07536 MMSA_BOVIN 99.628 0.996283 1.00186 ALDH6A1 - Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor - Bos taurus (Bovine) - ALDH6A1 gene Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. Indicus|evm.model.CM009500.1.894 Q8CD94 LIN52_MOUSE 100.000 0.982906 1.00862 Lin52 - Protein lin-52 homolog - Mus musculus (Mouse) - Lin52 gene Indicus|evm.model.CM009500.1.895 P58304 VSX2_HUMAN 92.798 0.994475 1.00277 VSX2 - Visual system homeobox 2 - Homo sapiens (Human) - VSX2 gene Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters (PubMed:27301076). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1 (PubMed:17919464, PubMed:27477290). Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1 (By similarity). Acts as a negative transcriptional regulator of MITF (By similarity). Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements (PubMed:16236706, PubMed:27477290). Binds to the photoreceptor conserved element-1 (PCE-1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells (By similarity). Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation (By similarity). May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling (PubMed:27301076). Indicus|evm.model.CM009500.1.896 O14678 ABCD4_HUMAN 89.439 0.996705 1.00165 ABCD4 - Lysosomal cobalamin transporter ABCD4 - Homo sapiens (Human) - ABCD4 gene Lysosomal transporter that plays a role in the lysosomal release of vitamin B12 into the cytosol (PubMed:22922874). Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane (PubMed:27456980). Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791). Indicus|evm.model.CM009500.1.897 E1BP92 VRTN_BOVIN 93.857 0.997147 1.06535 VRTN - Vertnin - Bos taurus (Bovine) - VRTN gene Indicus|evm.model.CM009500.1.898 A4IFJ1 SYN1L_BOVIN 99.580 0.991632 1.0042 SYNDIG1L - Synapse differentiation-inducing gene protein 1-like - Bos taurus (Bovine) - SYNDIG1L gene Indicus|evm.model.CM009500.1.899 P79345 NPC2_BOVIN 100.000 0.986667 1.00671 NPC2 - NPC intracellular cholesterol transporter 2 precursor - Bos taurus (Bovine) - NPC2 gene Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:29580834, PubMed:17552909). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (By similarity). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17573352). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity). Indicus|evm.model.CM009500.1.900 Q2TBG7 ISCA2_BOVIN 98.693 0.987013 1.01316 ISCA2 - Iron-sulfur cluster assembly 2 homolog, mitochondrial precursor - Bos taurus (Bovine) - ISCA2 gene Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. Indicus|evm.model.CM009500.1.901 Q28019 LTBP2_BOVIN 97.937 0.936434 1.05049 LTBP2 - Latent-transforming growth factor beta-binding protein 2 precursor - Bos taurus (Bovine) - LTBP2 gene May play an integral structural role in elastic-fiber architectural organization and/or assembly. Indicus|evm.model.CM009500.1.902 O15033 AREL1_HUMAN 97.205 0.997573 1.00122 AREL1 - Apoptosis-resistant E3 ubiquitin protein ligase 1 - Homo sapiens (Human) - AREL1 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation (PubMed:23479728). Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312). Indicus|evm.model.CM009500.1.903 Q5RFQ0 FCF1_PONAB 100.000 0.98995 1.00505 FCF1 - rRNA-processing protein FCF1 homolog - Pongo abelii (Sumatran orangutan) - FCF1 gene Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Indicus|evm.model.CM009500.1.904 Q9R0I7 YLPM1_MOUSE 95.263 0.0880708 1.54834 Ylpm1 - YLP motif-containing protein 1 - Mus musculus (Mouse) - Ylpm1 gene Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation. Indicus|evm.model.CM009500.1.905 Q3B8N5 PROX2_HUMAN 66.998 0.98791 0.978041 PROX2 - Prospero homeobox protein 2 - Homo sapiens (Human) - PROX2 gene Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Indicus|evm.model.CM009500.1.906 P11179 ODO2_BOVIN 92.544 0.856061 1.16044 DLST - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor - Bos taurus (Bovine) - DLST gene Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). Indicus|evm.model.CM009500.1.907 Q5RA67 RPKL1_PONAB 78.040 0.99637 1.00364 RPS6KL1 - Ribosomal protein S6 kinase-like 1 - Pongo abelii (Sumatran orangutan) - RPS6KL1 gene Indicus|evm.model.CM009500.1.908 Q9XS47 PLGF_BOVIN 87.647 0.988304 1.14765 PGF - Placenta growth factor precursor - Bos taurus (Bovine) - PGF gene Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity). Indicus|evm.model.CM009500.1.909 Q5E9B4 EI2BB_BOVIN 100.000 0.994318 1.00285 EIF2B2 - Translation initiation factor eIF-2B subunit beta - Bos taurus (Bovine) - EIF2B2 gene Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Indicus|evm.model.CM009500.1.910 Q9UHC1 MLH3_HUMAN 79.708 0.947125 1.04129 MLH3 - DNA mismatch repair protein Mlh3 - Homo sapiens (Human) - MLH3 gene Probably involved in the repair of mismatches in DNA. Indicus|evm.model.CM009500.1.911 P41500 ACYP1_BOVIN 97.030 0.625 1.58416 ACYP1 - Acylphosphatase-1 - Bos taurus (Bovine) - ACYP1 gene acylphosphatase activity Indicus|evm.model.CM009500.1.912 Q9BGW4 ZC21C_MACFA 72.795 0.996234 1 ZC2HC1C - Zinc finger C2HC domain-containing protein 1C - Macaca fascicularis (Crab-eating macaque) - ZC2HC1C gene Indicus|evm.model.CM009500.1.913 Q8TD19 NEK9_HUMAN 96.118 0.997955 0.998979 NEK9 - Serine/threonine-protein kinase Nek9 - Homo sapiens (Human) - NEK9 gene Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. Indicus|evm.model.CM009500.1.914 Q5E971 TMEDA_BOVIN 83.562 0.989418 0.863014 TMED10 - Transmembrane emp24 domain-containing protein 10 precursor - Bos taurus (Bovine) - TMED10 gene Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi. The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes. Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side. Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles. In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER (By similarity). Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (By similarity). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity) (By similarity). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (By similarity). On Golgi membranes, acts as primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus. Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization. In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC. Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha-crystallin B chain HSPB5, the carbohydrate-binding proteins galectin-1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9. Could also associates with the presenilin-dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40 (By similarity). Indicus|evm.model.CM009500.1.915 O77628 FOS_BOVIN 100.000 0.994751 1.00263 FOS - Proto-oncogene c-Fos - Bos taurus (Bovine) - FOS gene Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity). Indicus|evm.model.CM009500.1.916 Q4R7U3 GLNA_MACFA 85.366 0.254902 0.409091 GLUL - Glutamine synthetase - Macaca fascicularis (Crab-eating macaque) - GLUL gene Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Indicus|evm.model.CM009500.1.917 Q8WYK2 JDP2_HUMAN 97.546 0.576512 1.72393 JDP2 - Jun dimerization protein 2 - Homo sapiens (Human) - JDP2 gene Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. Indicus|evm.model.CM009500.1.918 E1BD44 BATF_BOVIN 100.000 0.984127 1.008 BATF - Basic leucine zipper transcriptional factor ATF-like - Bos taurus (Bovine) - BATF gene AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity). Indicus|evm.model.CM009500.1.919 Q91X85 FLVC2_MOUSE 79.186 0.44332 0.896552 Flvcr2 - Feline leukemia virus subgroup C receptor-related protein 2 - Mus musculus (Mouse) - Flvcr2 gene Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism (By similarity). Indicus|evm.model.CM009500.1.920 Q96DR4 STAR4_HUMAN 88.780 0.976077 1.01951 STARD4 - StAR-related lipid transfer protein 4 - Homo sapiens (Human) - STARD4 gene Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols. Indicus|evm.model.CM009500.1.922 Q16566 KCC4_HUMAN 87.037 0.335443 0.334038 CAMK4 - Calcium/calmodulin-dependent protein kinase type IV - Homo sapiens (Human) - CAMK4 gene Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. Indicus|evm.model.CM009500.1.923 Q8NI36 WDR36_HUMAN 92.626 0.997768 0.942166 WDR36 - WD repeat-containing protein 36 - Homo sapiens (Human) - WDR36 gene Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2. Indicus|evm.model.CM009500.1.924 Q969D9 TSLP_HUMAN 55.000 0.852761 1.02516 TSLP - Thymic stromal lymphopoietin precursor - Homo sapiens (Human) - TSLP gene Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. Indicus|evm.model.CM009500.1.925 Q9ERY9 ERG28_MOUSE 83.333 0.411255 1.65 Erg28 - Ergosterol biosynthetic protein 28 homolog - Mus musculus (Mouse) - Erg28 gene endoplasmic reticulum, transport vesicle, identical protein binding, protein-macromolecule adaptor activity Indicus|evm.model.CM009500.1.926 Q9UPI3 FLVC2_HUMAN 84.487 0.898925 0.88403 FLVCR2 - Feline leukemia virus subgroup C receptor-related protein 2 - Homo sapiens (Human) - FLVCR2 gene Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism. Indicus|evm.model.CM009500.1.927 Q9ERY9 ERG28_MOUSE 88.571 0.985816 1.00714 Erg28 - Ergosterol biosynthetic protein 28 homolog - Mus musculus (Mouse) - Erg28 gene endoplasmic reticulum, transport vesicle, identical protein binding, protein-macromolecule adaptor activity Indicus|evm.model.CM009500.1.929 Q5R978 TTLL5_PONAB 91.781 0.997715 1.01078 TTLL5 - Tubulin polyglutamylase TTLL5 - Pongo abelii (Sumatran orangutan) - TTLL5 gene Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (By similarity). Indicus|evm.model.CM009500.1.930 P15203 TGFB3_PIG 94.132 0.898455 1.10758 TGFB3 - Transforming growth factor beta-3 proprotein precursor - Sus scrofa (Pig) - TGFB3 gene Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Indicus|evm.model.CM009500.1.931 Q2TBN9 IFT43_BOVIN 99.517 0.990385 1.00483 IFT43 - Intraflagellar transport protein 43 homolog - Bos taurus (Bovine) - IFT43 gene As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base. Indicus|evm.model.CM009500.1.933 Q9NWQ4 GPT2L_HUMAN 91.340 0.813675 1.21369 GPATCH2L - G patch domain-containing protein 2-like - Homo sapiens (Human) - GPATCH2L gene Indicus|evm.model.CM009500.1.934 O95718 ERR2_HUMAN 98.152 0.995392 1.00231 ESRRB - Steroid hormone receptor ERR2 - Homo sapiens (Human) - ESRRB gene Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity). Indicus|evm.model.CM009500.1.935 Q7L8A9 VASH1_HUMAN 94.521 0.994505 0.99726 VASH1 - Tubulinyl-Tyr carboxypeptidase 1 - Homo sapiens (Human) - VASH1 gene Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869, PubMed:31270470, PubMed:31235910, PubMed:31171830, PubMed:31235911). Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096). Indicus|evm.model.CM009500.1.936 Q9UNK9 ANGE1_HUMAN 90.909 0.99701 0.998507 ANGEL1 - Protein angel homolog 1 - Homo sapiens (Human) - ANGEL1 gene cis-Golgi network, cytosol, endoplasmic reticulum, nucleus, perinuclear region of cytoplasm, 3'-5'-exoribonuclease activity, eukaryotic initiation factor 4E binding, protein domain specific binding Indicus|evm.model.CM009500.1.937 A0JPI9 LR74A_RAT 75.699 0.826476 1.16701 Lrrc74a - Leucine-rich repeat-containing protein 74A - Rattus norvegicus (Rat) - Lrrc74a gene Indicus|evm.model.CM009500.1.938 Q2MJS2 I2BPL_MACMU 95.718 0.997419 0.976071 IRF2BPL - Probable E3 ubiquitin-protein ligase IRF2BPL - Macaca mulatta (Rhesus macaque) - IRF2BPL gene Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). Indicus|evm.model.CM009500.1.939 Q5R8C5 CIPC_PONAB 86.216 0.994987 1 CIPC - CLOCK-interacting pacemaker - Pongo abelii (Sumatran orangutan) - CIPC gene Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock. Indicus|evm.model.CM009500.1.940 Q8N966 ZDH22_HUMAN 95.057 0.992424 1.0038 ZDHHC22 - Palmitoyltransferase ZDHHC22 - Homo sapiens (Human) - ZDHHC22 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (PubMed:22399288). Catalyzes the palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (PubMed:22399288). Might also mediate palmitoylation of CNN3 (By similarity). Indicus|evm.model.CM009500.1.941 Q9P1W3 CSC1_HUMAN 77.116 0.997613 1.0397 TMEM63C - Calcium permeable stress-gated cation channel 1 - Homo sapiens (Human) - TMEM63C gene Acts as an osmosensitive calcium-permeable cation channel (PubMed:24503647). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Indicus|evm.model.CM009500.1.942 Q6WZ19 NGB_BOVIN 100.000 0.986842 1.00662 NGB - Neuroglobin - Bos taurus (Bovine) - NGB gene Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes (By similarity). Indicus|evm.model.CM009500.1.943 Q9UKY4 POMT2_HUMAN 90.957 0.912515 1.09733 POMT2 - Protein O-mannosyl-transferase 2 - Homo sapiens (Human) - POMT2 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:14699049, PubMed:28512129). Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129). Indicus|evm.model.CM009500.1.944 P57113 MAAI_RAT 78.603 0.987013 1.06944 Gstz1 - Maleylacetoacetate isomerase - Rattus norvegicus (Rat) - Gstz1 gene Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides (By similarity). Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. Indicus|evm.model.CM009500.1.945 Q6PL24 TMED8_HUMAN 85.276 0.993884 1.00615 TMED8 - Protein TMED8 - Homo sapiens (Human) - TMED8 gene Indicus|evm.model.CM009500.1.946 Q9P1V8 SAM15_HUMAN 47.527 0.997085 1.0178 SAMD15 - Sterile alpha motif domain-containing protein 15 - Homo sapiens (Human) - SAMD15 gene Indicus|evm.model.CM009500.1.947 Q6NXP6 NXRD1_HUMAN 68.665 0.940722 1.08078 NOXRED1 - NADP-dependent oxidoreductase domain-containing protein 1 - Homo sapiens (Human) - NOXRED1 gene Probable oxidoreductase. Indicus|evm.model.CM009500.1.948 A5D796 SPE39_BOVIN 97.764 0.995943 1.02495 VIPAS39 - Spermatogenesis-defective protein 39 homolog - Bos taurus (Bovine) - VIPAS39 gene Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). Indicus|evm.model.CM009500.1.949 O95433 AHSA1_HUMAN 96.450 0.9941 1.00296 AHSA1 - Activator of 90 kDa heat shock protein ATPase homolog 1 - Homo sapiens (Human) - AHSA1 gene Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Indicus|evm.model.CM009500.1.951 O15270 SPTC2_HUMAN 94.671 0.996448 1.00178 SPTLC2 - Serine palmitoyltransferase 2 - Homo sapiens (Human) - SPTLC2 gene Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity). Indicus|evm.model.CM009500.1.952 Q13686 ALKB1_HUMAN 86.340 0.992308 1.00257 ALKBH1 - Nucleic acid dioxygenase ALKBH1 - Homo sapiens (Human) - ALKBH1 gene Dioxygenase that acts as on nucleic acids, such as DNA and tRNA (PubMed:18603530, PubMed:27745969, PubMed:27497299). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:18603530, PubMed:27497299). A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment (PubMed:27745969, PubMed:27497299). Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs (PubMed:27745969). Acts as a regulator of translation initiation and elongation in response to glucose deprivation: regulates both translation initiation, by mediating demethylation of tRNA(Met), and translation elongation, N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation (PubMed:27745969). In mitochondrion, specifically interacts with mt-tRNA(Met) and mediates oxidation of mt-tRNA(Met) methylated at cytosine(34) to form 5-formylcytosine (f(5)c) at this position (PubMed:27497299). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299). Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:30392959, PubMed:30017583). N(6)-methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (By similarity). Demethylates mRNAs containing N(3)-methylcytidine modification (PubMed:31188562). Also able to repair alkylated single-stranded DNA by oxidative demethylation, but with low activity (PubMed:18603530). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites (PubMed:19959401). DNA lyase activity does not require alpha-ketboglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product (PubMed:19959401, PubMed:23577621). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation (By similarity). Indicus|evm.model.CM009500.1.953 Q32P59 SLIRP_BOVIN 100.000 0.982143 1.00901 SLIRP - SRA stem-loop-interacting RNA-binding protein, mitochondrial precursor - Bos taurus (Bovine) - SLIRP gene RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity). Indicus|evm.model.CM009500.1.954 Q1JQE0 SNW1_BOVIN 100.000 0.996276 1.00187 SNW1 - SNW domain-containing protein 1 - Bos taurus (Bovine) - SNW1 gene Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Indicus|evm.model.CM009500.1.955 Q86TW2 ADCK1_HUMAN 86.742 0.992366 0.988679 ADCK1 - AarF domain-containing protein kinase 1 precursor - Homo sapiens (Human) - ADCK1 gene Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (PubMed:31125351). The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). Indicus|evm.model.CM009500.1.956 Q9Y4C0 NRX3A_HUMAN 93.220 0.873606 0.163725 NRXN3 - Neurexin-3 precursor - Homo sapiens (Human) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Indicus|evm.model.CM009500.1.957 Q6P9K9 NRX3A_MOUSE 98.718 0.851648 0.11585 Nrxn3 - Neurexin-3 precursor - Mus musculus (Mouse) - Nrxn3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). Indicus|evm.model.CM009500.1.958 Q9Y4C0 NRX3A_HUMAN 96.875 0.92029 0.0839927 NRXN3 - Neurexin-3 precursor - Homo sapiens (Human) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Indicus|evm.model.CM009500.1.959 Q6P9K9 NRX3A_MOUSE 100.000 0.631841 0.127944 Nrxn3 - Neurexin-3 precursor - Mus musculus (Mouse) - Nrxn3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). Indicus|evm.model.CM009500.1.960 Q9Y4C0 NRX3A_HUMAN 95.082 0.869565 0.0419963 NRXN3 - Neurexin-3 precursor - Homo sapiens (Human) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Indicus|evm.model.CM009500.1.961 Q9Y4C0 NRX3A_HUMAN 95.942 0.864322 0.24224 NRXN3 - Neurexin-3 precursor - Homo sapiens (Human) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Indicus|evm.model.CM009500.1.963 Q6P9K9 NRX3A_MOUSE 88.571 0.841463 0.0521961 Nrxn3 - Neurexin-3 precursor - Mus musculus (Mouse) - Nrxn3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). Indicus|evm.model.CM009500.1.964 Q28143 NRX3B_BOVIN 100.000 0.422222 0.296053 NRXN3 - Neurexin-3-beta precursor - Bos taurus (Bovine) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity). Indicus|evm.model.CM009500.1.965 Q28143 NRX3B_BOVIN 100.000 0.731481 0.473684 NRXN3 - Neurexin-3-beta precursor - Bos taurus (Bovine) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity). Indicus|evm.model.CM009500.1.966 Q9Y4C0 NRX3A_HUMAN 96.764 0.956522 0.195983 NRXN3 - Neurexin-3 precursor - Homo sapiens (Human) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Indicus|evm.model.CM009500.1.967 Q5I3B2 IOD2_BOVIN 87.547 0.849265 1.01115 DIO2 - Type II iodothyronine deiodinase - Bos taurus (Bovine) - DIO2 gene Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. Indicus|evm.model.CM009500.1.968 P79103 RS4_BOVIN 95.057 0.992424 1.0038 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009500.1.969 Q6ZU80 CE128_HUMAN 85.092 0.992009 0.800731 CEP128 - Centrosomal protein of 128 kDa - Homo sapiens (Human) - CEP128 gene centriolar subdistal appendage, centriole, spindle pole, protein localization Indicus|evm.model.CM009500.1.970 Q27987 TSHR_BOVIN 93.316 0.997203 0.93709 TSHR - Thyrotropin receptor precursor - Bos taurus (Bovine) - TSHR gene Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Indicus|evm.model.CM009500.1.971 P52655 TF2AA_HUMAN 99.110 0.994083 0.898936 GTF2A1 - Transcription initiation factor IIA subunit 1 - Homo sapiens (Human) - GTF2A1 gene TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. Indicus|evm.model.CM009500.1.972 Q8WXE9 STON2_HUMAN 86.499 0.971047 0.992265 STON2 - Stonin-2 - Homo sapiens (Human) - STON2 gene Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. Indicus|evm.model.CM009500.1.973 Q9UBV2 SE1L1_HUMAN 95.340 0.997484 1.00126 SEL1L - Protein sel-1 homolog 1 precursor - Homo sapiens (Human) - SEL1L gene Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. Indicus|evm.model.CM009500.1.977 Q29RK1 CISY_BOVIN 98.106 0.992453 0.56867 CS - Citrate synthase, mitochondrial precursor - Bos taurus (Bovine) - CS gene mitochondrial matrix, citrate (Si)-synthase activity, carbohydrate metabolic process, tricarboxylic acid cycle Indicus|evm.model.CM009500.1.978 Q29RK1 CISY_BOVIN 97.638 0.926471 0.291845 CS - Citrate synthase, mitochondrial precursor - Bos taurus (Bovine) - CS gene mitochondrial matrix, citrate (Si)-synthase activity, carbohydrate metabolic process, tricarboxylic acid cycle Indicus|evm.model.CM009500.1.982 O43155 FLRT2_HUMAN 94.697 0.996974 1.00152 FLRT2 - Leucine-rich repeat transmembrane protein FLRT2 precursor - Homo sapiens (Human) - FLRT2 gene Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. Indicus|evm.model.CM009500.1.985 Q61553 FSCN1_MOUSE 46.154 0.407583 0.427992 Fscn1 - Fascin - Mus musculus (Mouse) - Fscn1 gene Actin-binding protein that contains 2 major actin binding sites (By similarity). Organizes filamentous actin into parallel bundles (PubMed:7738015). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (By similarity). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:21685497). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (By similarity). Indicus|evm.model.CM009500.1.986 Q8TBF4 ZCRB1_HUMAN 88.889 0.59322 0.271889 ZCRB1 - Zinc finger CCHC-type and RNA-binding motif-containing protein 1 - Homo sapiens (Human) - ZCRB1 gene cytosol, nucleoplasm, U12-type spliceosomal complex, RNA binding, mRNA splicing, via spliceosome, RNA splicing Indicus|evm.model.CM009500.1.987 Q8TBF4 ZCRB1_HUMAN 90.323 0.824324 0.341014 ZCRB1 - Zinc finger CCHC-type and RNA-binding motif-containing protein 1 - Homo sapiens (Human) - ZCRB1 gene cytosol, nucleoplasm, U12-type spliceosomal complex, RNA binding, mRNA splicing, via spliceosome, RNA splicing Indicus|evm.model.CM009500.1.988 Q922R8 PDIA6_MOUSE 89.091 0.995238 0.954545 Pdia6 - Protein disulfide-isomerase A6 precursor - Mus musculus (Mouse) - Pdia6 gene May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:24508390). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (By similarity). May also regulate the UPR via the EIF2AK3 UPR sensor (By similarity). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity). Indicus|evm.model.CM009500.1.989 O00370 LORF2_HUMAN 78.169 0.538168 0.20549 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Indicus|evm.model.CM009500.1.991 P54804 GALC_CANLF 88.341 0.966715 1.03288 GALC - Galactocerebrosidase precursor - Canis lupus familiaris (Dog) - GALC gene Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine (PubMed:8661004). Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity). Indicus|evm.model.CM009500.1.992 Q8IYL9 PSYR_HUMAN 78.886 0.994152 1.01484 GPR65 - Psychosine receptor - Homo sapiens (Human) - GPR65 gene Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity). Indicus|evm.model.CM009500.1.994 P57789 KCNKA_HUMAN 98.214 0.469101 0.66171 KCNK10 - Potassium channel subfamily K member 10 - Homo sapiens (Human) - KCNK10 gene Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. Indicus|evm.model.CM009500.1.995 Q9P0W8 SPAT7_HUMAN 70.470 0.99661 0.984975 SPATA7 - Spermatogenesis-associated protein 7 - Homo sapiens (Human) - SPATA7 gene Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity). Indicus|evm.model.CM009500.1.996 Q16825 PTN21_HUMAN 91.603 0.34629 0.964225 PTPN21 - Tyrosine-protein phosphatase non-receptor type 21 - Homo sapiens (Human) - PTPN21 gene cytoplasm, cytoskeleton, protein tyrosine phosphatase activity, protein dephosphorylation Indicus|evm.model.CM009500.1.997 Q3ZC82 ZC3HE_BOVIN 99.715 0.997151 0.955102 ZC3H14 - Zinc finger CCCH domain-containing protein 14 - Bos taurus (Bovine) - ZC3H14 gene Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides. Indicus|evm.model.CM009500.1.998 Q05BV3 EMAL5_HUMAN 96.368 0.989367 1.00305 EML5 - Echinoderm microtubule-associated protein-like 5 - Homo sapiens (Human) - EML5 gene May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. Indicus|evm.model.CM009500.1.999 Q8VD72 TTC8_MOUSE 90.329 0.995807 0.926214 Ttc8 - Tetratricopeptide repeat protein 8 - Mus musculus (Mouse) - Ttc8 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (By similarity). Indicus|evm.model.CM009500.1.1002 Q28G71 FOXN3_XENTR 85.075 0.670034 0.640086 foxn3 - Forkhead box protein N3 - Xenopus tropicalis (Western clawed frog) - foxn3 gene Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) (By similarity). Indicus|evm.model.CM009500.1.1005 Q9BUY7 EFC11_HUMAN 82.822 0.975904 1.0184 EFCAB11 - EF-hand calcium-binding domain-containing protein 11 - Homo sapiens (Human) - EFCAB11 gene calcium ion binding Indicus|evm.model.CM009500.1.1006 Q9NUW8 TYDP1_HUMAN 82.353 0.995106 1.00822 TDP1 - Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens (Human) - TDP1 gene DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. Indicus|evm.model.CM009500.1.1007 Q9ERS0 KCNKD_RAT 74.510 0.561798 0.219753 Kcnk13 - Potassium channel subfamily K member 13 - Rattus norvegicus (Rat) - Kcnk13 gene Potassium channel displaying weak inward rectification in symmetrical K(+) solution. Indicus|evm.model.CM009500.1.1008 P62193 PRS4_RAT 100.000 0.869307 1.14773 Psmc1 - 26S proteasome regulatory subunit 4 - Rattus norvegicus (Rat) - Psmc1 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Indicus|evm.model.CM009500.1.1009 Q9H7Z3 NRDE2_HUMAN 79.567 0.987889 0.993127 NRDE2 - Nuclear exosome regulator NRDE2 - Homo sapiens (Human) - NRDE2 gene Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (PubMed:30538148). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (PubMed:30538148). Plays a role in DNA damage response (PubMed:29902117). Indicus|evm.model.CM009500.1.1010 P0DP31 CALM3_RAT 100.000 0.97351 1.01342 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Indicus|evm.model.CM009500.1.1011 Q86TV6 TTC7B_HUMAN 95.859 0.840549 1.12337 TTC7B - Tetratricopeptide repeat protein 7B - Homo sapiens (Human) - TTC7B gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (PubMed:26571211). Indicus|evm.model.CM009500.1.1012 O75582 KS6A5_HUMAN 94.902 0.801679 1.18828 RPS6KA5 - Ribosomal protein S6 kinase alpha-5 - Homo sapiens (Human) - RPS6KA5 gene Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). Indicus|evm.model.CM009500.1.1014 A2VE10 GOLM2_BOVIN 95.833 0.0602094 1.00526 GOLM2 - Protein GOLM2 - Bos taurus (Bovine) - GOLM2 gene Indicus|evm.model.CM009500.1.1015 Q05D32 CTSL2_HUMAN 99.356 0.995717 1.00215 CTDSPL2 - CTD small phosphatase-like protein 2 - Homo sapiens (Human) - CTDSPL2 gene Probable phosphatase. Indicus|evm.model.CM009500.1.1017 Q0VCU8 EIF3J_BOVIN 99.608 0.984496 1.00781 EIF3J - Eukaryotic translation initiation factor 3 subunit J - Bos taurus (Bovine) - EIF3J gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA. Indicus|evm.model.CM009500.1.1018 Q96JI7 SPTCS_HUMAN 83.436 0.998765 0.994269 SPG11 - Spatacsin - Homo sapiens (Human) - SPG11 gene May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. Indicus|evm.model.CM009500.1.1019 C9JE40 PATL2_HUMAN 81.117 0.742574 0.930018 PATL2 - Protein PAT1 homolog 2 - Homo sapiens (Human) - PATL2 gene RNA-binding protein that acts as a translational repressor. Indicus|evm.model.CM009500.1.1020 P01888 B2MG_BOVIN 100.000 0.983193 1.00847 B2M - Beta-2-microglobulin precursor - Bos taurus (Bovine) - B2M gene Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Indicus|evm.model.CM009500.1.1021 Q29RI9 MAT2B_BOVIN 98.802 0.99403 1.00299 MAT2B - Methionine adenosyltransferase 2 subunit beta - Bos taurus (Bovine) - MAT2B gene Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro). Indicus|evm.model.CM009500.1.1022 Q86WT6 TRI69_HUMAN 87.799 0.995227 0.838 TRIM69 - E3 ubiquitin-protein ligase TRIM69 - Homo sapiens (Human) - TRIM69 gene May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis. Indicus|evm.model.CM009501.1.1 P61129 ZC3H6_HUMAN 82.269 0.998259 0.966358 ZC3H6 - Zinc finger CCCH domain-containing protein 6 - Homo sapiens (Human) - ZC3H6 gene chromatin, nucleus Indicus|evm.model.CM009501.1.2 Q8N5P1 ZC3H8_HUMAN 74.510 0.986971 1.05498 ZC3H8 - Zinc finger CCCH domain-containing protein 8 - Homo sapiens (Human) - ZC3H8 gene Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. Indicus|evm.model.CM009501.1.3 Q53RD9 FBLN7_HUMAN 90.888 0.995455 1.00228 FBLN7 - Fibulin-7 precursor - Homo sapiens (Human) - FBLN7 gene An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation. Indicus|evm.model.CM009501.1.4 Q96K49 TM87B_HUMAN 81.705 0.996441 1.01261 TMEM87B - Transmembrane protein 87B precursor - Homo sapiens (Human) - TMEM87B gene May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). Indicus|evm.model.CM009501.1.5 Q12866 MERTK_HUMAN 82.281 0.98 1.001 MERTK - Tyrosine-protein kinase Mer precursor - Homo sapiens (Human) - MERTK gene Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Indicus|evm.model.CM009501.1.6 Q9H1A4 APC1_HUMAN 95.628 0.998971 1 ANAPC1 - Anaphase-promoting complex subunit 1 - Homo sapiens (Human) - ANAPC1 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Indicus|evm.model.CM009501.1.7 A6NJR5 SPDL3_HUMAN 58.065 0.620513 0.672414 Putative speedy protein-like protein 3 - Homo sapiens (Human) Indicus|evm.model.CM009501.1.8 A1A4Q3 HBM_BOVIN 97.260 0.585366 0.87234 HBM - Hemoglobin subunit mu - Bos taurus (Bovine) - HBM gene haptoglobin-hemoglobin complex, hemoglobin complex, heme binding, organic acid binding, oxygen binding, oxygen carrier activity, hydrogen peroxide catabolic process Indicus|evm.model.CM009501.1.10 Q17QD9 CSEN_BOVIN 92.683 0.515284 0.894531 KCNIP3 - Calsenilin - Bos taurus (Bovine) - KCNIP3 gene Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Indicus|evm.model.CM009501.1.11 O43521 B2L11_HUMAN 87.500 0.989796 0.989899 BCL2L11 - Bcl-2-like protein 11 - Homo sapiens (Human) - BCL2L11 gene Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. Indicus|evm.model.CM009501.1.12 Q9NUZ1 ACOXL_HUMAN 88.889 0.138199 1.17733 ACOXL - Acyl-coenzyme A oxidase-like protein - Homo sapiens (Human) - ACOXL gene peroxisomal matrix, peroxisome, acyl-CoA oxidase activity, fatty acid binding, flavin adenine dinucleotide binding, fatty acid beta-oxidation using acyl-CoA oxidase, lipid homeostasis Indicus|evm.model.CM009501.1.13 Q9NUZ1 ACOXL_HUMAN 88.202 0.907692 0.35649 ACOXL - Acyl-coenzyme A oxidase-like protein - Homo sapiens (Human) - ACOXL gene peroxisomal matrix, peroxisome, acyl-CoA oxidase activity, fatty acid binding, flavin adenine dinucleotide binding, fatty acid beta-oxidation using acyl-CoA oxidase, lipid homeostasis Indicus|evm.model.CM009501.1.15 O43683 BUB1_HUMAN 78.913 0.998152 0.997235 BUB1 - Mitotic checkpoint serine/threonine-protein kinase BUB1 - Homo sapiens (Human) - BUB1 gene Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. Indicus|evm.model.CM009501.1.17 Q8NCU8 MTLN_HUMAN 96.429 0.964912 1.01786 MTLN - Mitoregulin - Homo sapiens (Human) - MTLN gene Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species (PubMed:29949756). Increases mitochondrial respiration rate (PubMed:29949756). Increased mitochondrial respiratory activity promotes myogenic differentiation which facilitates muscle growth and regeneration (By similarity). Increases mitochondrial calcium retention capacity (PubMed:29949756). Plays a role in maintenance of cellular lipid composition through its interaction with cytochrome b5 reductase CYB5R3 which is required for mitochondrial respiratory complex I activity (By similarity). Interacts with the mitochondrial trifunctional enzyme complex (MTE) and enhances fatty acid beta-oxidation (PubMed:32243843). Not required for MTE formation or stability (By similarity). Modulates triglyceride clearance in adipocytes through its role in regulating fatty acid beta-oxidation and lipolysis (PubMed:32243843). Indicus|evm.model.CM009501.1.18 Q9TU19 NPHP1_CANLF 86.891 0.612198 1.53805 NPHP1 - Nephrocystin-1 - Canis lupus familiaris (Dog) - NPHP1 gene Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (By similarity). Required for normal retina development (By similarity). In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity). Indicus|evm.model.CM009501.1.19 Q3ZBY0 MAL_BOVIN 100.000 0.987013 1.00654 MAL - Myelin and lymphocyte protein - Bos taurus (Bovine) - MAL gene Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function (By similarity). Indicus|evm.model.CM009501.1.20 Q28296 MAL_CANLF 69.935 0.94375 1.04575 MAL - Myelin and lymphocyte protein - Canis lupus familiaris (Dog) - MAL gene Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function. Indicus|evm.model.CM009501.1.21 Q2KID9 RT05_BOVIN 99.767 0.99536 1.00233 MRPS5 - 28S ribosomal protein S5, mitochondrial - Bos taurus (Bovine) - MRPS5 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation, translation Indicus|evm.model.CM009501.1.22 Q96K75 ZN514_HUMAN 72.727 0.689655 0.435 ZNF514 - Zinc finger protein 514 - Homo sapiens (Human) - ZNF514 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009501.1.23 Q6ECI4 ZN470_HUMAN 59.587 0.417817 1.11158 ZNF470 - Zinc finger protein 470 - Homo sapiens (Human) - ZNF470 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009501.1.24 Q8N271 PROM2_HUMAN 77.928 0.970024 1 PROM2 - Prominin-2 precursor - Homo sapiens (Human) - PROM2 gene apical plasma membrane, cell projection, cell surface, cilium, cytoplasmic vesicle, extracellular exosome, integral component of plasma membrane, microspike, microvillus, prominosome Indicus|evm.model.CM009501.1.25 Q17QD9 CSEN_BOVIN 96.689 0.592885 0.988281 KCNIP3 - Calsenilin - Bos taurus (Bovine) - KCNIP3 gene Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Indicus|evm.model.CM009501.1.26 Q2KIB0 FAHD2_BOVIN 99.363 0.993651 1.00318 FAHD2 - Fumarylacetoacetate hydrolase domain-containing protein 2 - Bos taurus (Bovine) - FAHD2 gene May have hydrolase activity. Indicus|evm.model.CM009501.1.27 Q6NUI2 GPAT2_HUMAN 85.019 0.997503 1.00755 GPAT2 - Glycerol-3-phosphate acyltransferase 2, mitochondrial - Homo sapiens (Human) - GPAT2 gene Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. Indicus|evm.model.CM009501.1.28 O77700 ADA2B_BOVIN 99.745 0.872768 1.14286 ADRA2B - Alpha-2B adrenergic receptor - Bos taurus (Bovine) - ADRA2B gene Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Indicus|evm.model.CM009501.1.30 Q05923 DUS2_HUMAN 83.663 0.338384 1.89172 DUSP2 - Dual specificity protein phosphatase 2 - Homo sapiens (Human) - DUSP2 gene Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Indicus|evm.model.CM009501.1.31 Q9NQZ5 STAR7_HUMAN 92.203 0.993243 0.8 STARD7 - StAR-related lipid transfer protein 7, mitochondrial precursor - Homo sapiens (Human) - STARD7 gene May play a protective role in mucosal tissues by preventing exaggerated allergic responses. Indicus|evm.model.CM009501.1.32 O75204 TM127_HUMAN 99.580 0.991632 1.0042 TMEM127 - Transmembrane protein 127 - Homo sapiens (Human) - TMEM127 gene Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. Indicus|evm.model.CM009501.1.33 Q32PJ6 CIAO1_BOVIN 100.000 0.994118 1.00295 CIAO1 - Probable cytosolic iron-sulfur protein assembly protein CIAO1 - Bos taurus (Bovine) - CIAO1 gene Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (By similarity). Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). Indicus|evm.model.CM009501.1.34 O75643 U520_HUMAN 99.298 0.999064 1.00047 SNRNP200 - U5 small nuclear ribonucleoprotein 200 kDa helicase - Homo sapiens (Human) - SNRNP200 gene Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Indicus|evm.model.CM009501.1.35 P84246 H33_RABIT 97.059 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009501.1.36 Q6GPH6 IPIL1_HUMAN 90.842 0.994526 0.987387 ITPRIPL1 - Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 precursor - Homo sapiens (Human) - ITPRIPL1 gene membrane Indicus|evm.model.CM009501.1.37 Q15003 CND2_HUMAN 80.355 0.997241 0.978408 NCAPH - Condensin complex subunit 2 - Homo sapiens (Human) - NCAPH gene Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Indicus|evm.model.CM009501.1.38 Q96EH8 NEUL3_HUMAN 71.264 0.955556 1.03053 NEURL3 - E3 ubiquitin-protein ligase NEURL3 - Homo sapiens (Human) - NEURL3 gene E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation. Indicus|evm.model.CM009501.1.39 Q3SWY1 ARI5A_BOVIN 99.324 0.996627 1.00169 ARID5A - AT-rich interactive domain-containing protein 5A - Bos taurus (Bovine) - ARID5A gene DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes. May act as repressor and down-regulate enhancer-dependent gene expressison. May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention. Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors. As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock. Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity). Indicus|evm.model.CM009501.1.40 Q3KR73 KANL3_RAT 91.344 0.997725 1.00228 Kansl3 - KAT8 regulatory NSL complex subunit 3 - Rattus norvegicus (Rat) - Kansl3 gene As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. Indicus|evm.model.CM009501.1.41 A0AVI2 FR1L5_HUMAN 76.136 0.999041 1.0141 FER1L5 - Fer-1-like protein 5 - Homo sapiens (Human) - FER1L5 gene Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation. Indicus|evm.model.CM009501.1.42 Q2HJD1 LMA2L_BOVIN 96.936 0.994444 1.03448 LMAN2L - VIP36-like protein precursor - Bos taurus (Bovine) - LMAN2L gene May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 (By similarity). Indicus|evm.model.CM009501.1.43 Q6P4Q7 CNNM4_HUMAN 81.720 0.996689 0.779355 CNNM4 - Metal transporter CNNM4 - Homo sapiens (Human) - CNNM4 gene Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. Indicus|evm.model.CM009501.1.44 Q8NE01 CNNM3_HUMAN 91.489 0.852727 0.777935 CNNM3 - Metal transporter CNNM3 - Homo sapiens (Human) - CNNM3 gene Probable metal transporter. Indicus|evm.model.CM009501.1.45 Q86SG2 ANR23_HUMAN 81.046 0.993464 1.00328 ANKRD23 - Ankyrin repeat domain-containing protein 23 - Homo sapiens (Human) - ANKRD23 gene May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression. Indicus|evm.model.CM009501.1.46 Q0P5B9 ANR39_BOVIN 99.454 0.98913 1.00546 ANKRD39 - Ankyrin repeat domain-containing protein 39 - Bos taurus (Bovine) - ANKRD39 gene cytoplasm, nucleus, NAD+ ADP-ribosyltransferase activity, positive regulation of canonical Wnt signaling pathway, positive regulation of telomere capping, protein ADP-ribosylation, protein localization to chromosome, telomeric region Indicus|evm.model.CM009501.1.47 Q9C0C4 SEM4C_HUMAN 93.157 0.997602 1.0012 SEMA4C - Semaphorin-4C precursor - Homo sapiens (Human) - SEMA4C gene Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. Indicus|evm.model.CM009501.1.48 Q8IXR5 F178B_HUMAN 64.750 0.984686 0.961708 FAM178B - Protein FAM178B - Homo sapiens (Human) - FAM178B gene Indicus|evm.model.CM009501.1.49 P00428 COX5B_BOVIN 100.000 0.984615 1.00775 COX5B - Cytochrome c oxidase subunit 5B, mitochondrial precursor - Bos taurus (Bovine) - COX5B gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009501.1.50 A4IFE3 ACTY_BOVIN 87.037 0.994709 1.00532 ACTR1B - Beta-centractin - Bos taurus (Bovine) - ACTR1B gene Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity). Indicus|evm.model.CM009501.1.51 A0A1B0GVN3 CB092_HUMAN 49.242 0.821086 1.18113 C2orf92 - Uncharacterized protein C2orf92 precursor - Homo sapiens (Human) - C2orf92 gene Indicus|evm.model.CM009501.1.52 P43404 ZAP70_MOUSE 93.355 0.995146 1 Zap70 - Tyrosine-protein kinase ZAP-70 - Mus musculus (Mouse) - Zap70 gene Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). Indicus|evm.model.CM009501.1.53 Q92545 TM131_HUMAN 91.609 0.998934 0.996814 TMEM131 - Transmembrane protein 131 - Homo sapiens (Human) - TMEM131 gene May play a role in the immune response to viral infection. Indicus|evm.model.CM009501.1.54 Q502W6 VWA3B_HUMAN 77.654 0.968726 0.988408 VWA3B - von Willebrand factor A domain-containing protein 3B - Homo sapiens (Human) - VWA3B gene cytosol, nucleoplasm Indicus|evm.model.CM009501.1.55 Q29441 CNGA3_BOVIN 99.575 0.997171 1.00142 CNGA3 - Cyclic nucleotide-gated cation channel alpha-3 - Bos taurus (Bovine) - CNGA3 gene Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Could be responsible for cGMP-induced calcium entry in cells other than sensory cells. Might be involved in chemotaxis of sperm. Indicus|evm.model.CM009501.1.57 Q96PE3 INP4A_HUMAN 94.791 0.99794 0.993859 INPP4A - Inositol polyphosphate-4-phosphatase type I A - Homo sapiens (Human) - INPP4A gene Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:20463662, PubMed:15716355). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:30071275) (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). Indicus|evm.model.CM009501.1.58 Q3ZBG6 UNC50_BOVIN 100.000 0.697297 1.42857 UNC50 - Protein unc-50 homolog - Bos taurus (Bovine) - UNC50 gene May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity). Indicus|evm.model.CM009501.1.59 O77836 MGT4A_BOVIN 96.627 0.990079 0.942056 MGAT4A - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A - Bos taurus (Bovine) - MGAT4A gene Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells. Indicus|evm.model.CM009501.1.60 Q6NV74 CRCDL_HUMAN 70.538 0.489968 0.984407 CRACDL - CRACD-like protein - Homo sapiens (Human) - CRACDL gene Indicus|evm.model.CM009501.1.61 Q6NY15 TSG10_MOUSE 96.848 0.779395 1.28121 Tsga10 - Testis-specific gene 10 protein - Mus musculus (Mouse) - Tsga10 gene Plays a role in spermatogenesis (PubMed:14585816). When overexpressed, prevents nuclear localization of HIF1A (PubMed:16777103). Indicus|evm.model.CM009501.1.62 O46419 LIPT_BOVIN 100.000 0.994652 1.00268 LIPT1 - Lipoyltransferase 1, mitochondrial precursor - Bos taurus (Bovine) - LIPT1 gene Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes. Indicus|evm.model.CM009501.1.63 Q8WV92 MITD1_HUMAN 83.534 0.991968 1 MITD1 - MIT domain-containing protein 1 - Homo sapiens (Human) - MITD1 gene Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. Indicus|evm.model.CM009501.1.64 Q58DV5 RM30_BOVIN 100.000 0.987654 1.00621 MRPL30 - 39S ribosomal protein L30, mitochondrial precursor - Bos taurus (Bovine) - MRPL30 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Indicus|evm.model.CM009501.1.65 Q86SG7 LYG2_HUMAN 72.642 0.817829 1.21698 LYG2 - Lysozyme g-like protein 2 precursor - Homo sapiens (Human) - LYG2 gene May act as a potent antibacterial protein that may play a role in the innate immunity. Indicus|evm.model.CM009501.1.66 Q8N1E2 LYG1_HUMAN 69.663 0.494253 0.896907 LYG1 - Lysozyme g-like protein 1 precursor - Homo sapiens (Human) - LYG1 gene extracellular region, lysozyme activity, defense response to Gram-positive bacterium Indicus|evm.model.CM009501.1.67 O18883 TXND9_BOVIN 99.558 0.991189 1.00442 TXNDC9 - Thioredoxin domain-containing protein 9 - Bos taurus (Bovine) - TXNDC9 gene Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin. Indicus|evm.model.CM009501.1.68 O60841 IF2P_HUMAN 93.612 0.998361 1 EIF5B - Eukaryotic translation initiation factor 5B - Homo sapiens (Human) - EIF5B gene Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. Indicus|evm.model.CM009501.1.69 Q9UBZ9 REV1_HUMAN 82.199 0.728927 0.834532 REV1 - DNA repair protein REV1 - Homo sapiens (Human) - REV1 gene Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Indicus|evm.model.CM009501.1.71 P51826 AFF3_HUMAN 89.431 0.459865 1.08728 AFF3 - AF4/FMR2 family member 3 - Homo sapiens (Human) - AFF3 gene Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. Indicus|evm.model.CM009501.1.75 Q1L5Z9 LONF2_HUMAN 57.959 0.625 0.424403 LONRF2 - LON peptidase N-terminal domain and RING finger protein 2 - Homo sapiens (Human) - LONRF2 gene Indicus|evm.model.CM009501.1.76 O43529 CHSTA_HUMAN 90.028 0.620504 1.5618 CHST10 - Carbohydrate sulfotransferase 10 - Homo sapiens (Human) - CHST10 gene Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis. Indicus|evm.model.CM009501.1.77 Q0VBW8 NMS_BOVIN 96.552 0.413462 1.43448 NMS - Neuromedin-S precursor - Bos taurus (Bovine) - NMS gene Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. Indicus|evm.model.CM009501.1.78 Q0VCW8 PDCL3_BOVIN 99.583 0.991701 1.00417 PDCL3 - Phosducin-like protein 3 - Bos taurus (Bovine) - PDCL3 gene Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (By similarity). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity). Indicus|evm.model.CM009501.1.79 Q12923 PTN13_HUMAN 88.621 0.995633 0.184306 PTPN13 - Tyrosine-protein phosphatase non-receptor type 13 - Homo sapiens (Human) - PTPN13 gene Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). Indicus|evm.model.CM009501.1.80 A6QP84 SOAT_BOVIN 98.765 0.991803 0.647215 SLC10A6 - Solute carrier family 10 member 6 - Bos taurus (Bovine) - SLC10A6 gene Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner. Indicus|evm.model.CM009501.1.81 Q99743 NPAS2_HUMAN 83.495 0.885417 1.04854 NPAS2 - Neuronal PAS domain-containing protein 2 - Homo sapiens (Human) - NPAS2 gene Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes. Controls the circadian rhythm of NR0B2 expression by binding rhythmically to its promoter (By similarity). Mediates the diurnal variation in the expression of GABARA1 receptor in the brain and contributes to the regulation of anxiety-like behaviors and GABAergic neurotransmission in the ventral striatum (By similarity). Indicus|evm.model.CM009501.1.82 P62902 RL31_RAT 100.000 0.984127 1.008 Rpl31 - 60S ribosomal protein L31 - Rattus norvegicus (Rat) - Rpl31 gene cytosolic large ribosomal subunit, nucleolus, nucleoplasm, polysomal ribosome, synapse, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009501.1.83 O95759 TBCD8_HUMAN 91.266 0.997375 1.00263 TBC1D8 - TBC1 domain family member 8 - Homo sapiens (Human) - TBC1D8 gene May act as a GTPase-activating protein for Rab family protein(s). Indicus|evm.model.CM009501.1.84 Q9UKZ1 CNO11_HUMAN 99.333 0.995565 0.884314 CNOT11 - CCR4-NOT transcription complex subunit 11 - Homo sapiens (Human) - CNOT11 gene Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function. Indicus|evm.model.CM009501.1.85 Q8NC42 RN149_HUMAN 79.899 0.989848 0.985 RNF149 - E3 ubiquitin-protein ligase RNF149 precursor - Homo sapiens (Human) - RNF149 gene E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. Indicus|evm.model.CM009501.1.86 Q8IUH2 CREG2_HUMAN 79.255 0.98895 0.624138 CREG2 - Protein CREG2 precursor - Homo sapiens (Human) - CREG2 gene extracellular space Indicus|evm.model.CM009501.1.87 Q6ZV50 RFX8_HUMAN 74.074 0.986689 1.0256 RFX8 - DNA-binding protein RFX8 - Homo sapiens (Human) - RFX8 gene May be a transcription factor. Indicus|evm.model.CM009501.1.88 O95819 M4K4_HUMAN 96.394 0.341845 0.979822 MAP4K4 - Mitogen-activated protein kinase kinase kinase kinase 4 - Homo sapiens (Human) - MAP4K4 gene Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. Indicus|evm.model.CM009501.1.89 P27930 IL1R2_HUMAN 70.781 0.977556 1.00754 IL1R2 - Interleukin-1 receptor type 2 precursor - Homo sapiens (Human) - IL1R2 gene Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Indicus|evm.model.CM009501.1.90 Q7TQK0 CCNT2_MOUSE 54.412 0.507576 0.182573 Ccnt2 - Cyclin-T2 - Mus musculus (Mouse) - Ccnt2 gene Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA (By similarity). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (PubMed:16245309, PubMed:23060074, PubMed:12037670). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (By similarity). Involved in early embryo development (PubMed:19364821). Indicus|evm.model.CM009501.1.91 P14778 IL1R1_HUMAN 72.251 0.996516 1.00879 IL1R1 - Interleukin-1 receptor type 1 precursor - Homo sapiens (Human) - IL1R1 gene Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). Indicus|evm.model.CM009501.1.92 Q9HB29 ILRL2_HUMAN 68.036 0.957118 1.01391 IL1RL2 - Interleukin-1 receptor-like 2 precursor - Homo sapiens (Human) - IL1RL2 gene Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. Indicus|evm.model.CM009501.1.93 O95256 I18RA_HUMAN 71.926 0.284959 2.8414 IL18RAP - Interleukin-18 receptor accessory protein precursor - Homo sapiens (Human) - IL18RAP gene Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable). Indicus|evm.model.CM009501.1.94 Q6AI14 SL9A4_HUMAN 82.573 0.331492 0.907268 SLC9A4 - Sodium/hydrogen exchanger 4 - Homo sapiens (Human) - SLC9A4 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity). Indicus|evm.model.CM009501.1.95 Q9UBY0 SL9A2_HUMAN 96.497 0.428767 0.899015 SLC9A2 - Sodium/hydrogen exchanger 2 - Homo sapiens (Human) - SLC9A2 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption. Indicus|evm.model.CM009501.1.96 Q8NBP5 MFSD9_HUMAN 67.949 0.960905 1.02532 MFSD9 - Major facilitator superfamily domain-containing protein 9 - Homo sapiens (Human) - MFSD9 gene Indicus|evm.model.CM009501.1.97 A4IF75 TM182_BOVIN 100.000 0.470199 0.659389 TMEM182 - Transmembrane protein 182 precursor - Bos taurus (Bovine) - TMEM182 gene Indicus|evm.model.CM009501.1.98 O43572 AKA10_HUMAN 95.652 0.652381 0.317221 AKAP10 - A-kinase anchor protein 10, mitochondrial precursor - Homo sapiens (Human) - AKAP10 gene Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). Indicus|evm.model.CM009501.1.100 Q63262 PO3F3_RAT 99.479 0.816239 0.470825 Pou3f3 - POU domain, class 3, transcription factor 3 - Rattus norvegicus (Rat) - Pou3f3 gene Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity). Indicus|evm.model.CM009501.1.104 Q58DQ5 RT09_BOVIN 99.747 0.994962 1.00253 MRPS9 - 28S ribosomal protein S9, mitochondrial precursor - Bos taurus (Bovine) - MRPS9 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit, RNA binding, structural constituent of ribosome Indicus|evm.model.CM009501.1.105 Q9Y5Y3 GPR45_HUMAN 81.501 0.994652 1.00538 GPR45 - Probable G-protein coupled receptor 45 - Homo sapiens (Human) - GPR45 gene Orphan receptor. May play a role in brain function. Indicus|evm.model.CM009501.1.106 A7MB11 TGFA1_BOVIN 99.651 0.997674 1.00116 TGFBRAP1 - Transforming growth factor-beta receptor-associated protein 1 - Bos taurus (Bovine) - TGFBRAP1 gene Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity). Indicus|evm.model.CM009501.1.107 A2VDP0 ASHWN_BOVIN 100.000 0.991416 1.00431 Ashwin - Bos taurus (Bovine) Indicus|evm.model.CM009501.1.108 Q2KI95 FHL2_BOVIN 99.642 0.992857 1.00358 FHL2 - Four and a half LIM domains protein 2 - Bos taurus (Bovine) - FHL2 gene May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (By similarity). Indicus|evm.model.CM009501.1.109 Q5DUB3 NK1R_CANLF 95.332 0.995098 1.00246 TACR1 - Substance-P receptor - Canis lupus familiaris (Dog) - TACR1 gene This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Indicus|evm.model.CM009501.1.110 A6QQ14 DPOE4_BOVIN 98.261 0.735484 1.33621 POLE4 - DNA polymerase epsilon subunit 4 - Bos taurus (Bovine) - POLE4 gene Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Indicus|evm.model.CM009501.1.111 Q1W674 HXK2_PIG 97.710 0.997821 1.00109 HK2 - Hexokinase-2 - Sus scrofa (Pig) - HK2 gene Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Indicus|evm.model.CM009501.1.112 Q9Z123 SEM4F_MOUSE 90.135 0.955959 0.993565 Sema4f - Semaphorin-4F precursor - Mus musculus (Mouse) - Sema4f gene Probable cell surface receptor that regulates oligodendroglial precursor cell migration (PubMed:21945643). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity). Indicus|evm.model.CM009501.1.113 Q8TC57 M1AP_HUMAN 80.784 0.944238 0.507547 M1AP - Meiosis 1 arrest protein - Homo sapiens (Human) - M1AP gene Required for meiosis I progression during spermatogenesis. Indicus|evm.model.CM009501.1.114 Q8TC57 M1AP_HUMAN 77.459 0.944664 0.477358 M1AP - Meiosis 1 arrest protein - Homo sapiens (Human) - M1AP gene Required for meiosis I progression during spermatogenesis. Indicus|evm.model.CM009501.1.115 Q5EA84 DOK1_BOVIN 99.793 0.995868 1.00207 DOK1 - Docking protein 1 - Bos taurus (Bovine) - DOK1 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). Indicus|evm.model.CM009501.1.116 P58215 LOXL3_HUMAN 95.352 0.997344 1 LOXL3 - Lysyl oxidase homolog 3 precursor - Homo sapiens (Human) - LOXL3 gene Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600). Indicus|evm.model.CM009501.1.117 A0JNK3 HTRA2_BOVIN 100.000 0.995643 1.00218 HTRA2 - Serine protease HTRA2, mitochondrial precursor - Bos taurus (Bovine) - HTRA2 gene Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis (By similarity). Indicus|evm.model.CM009501.1.118 Q9Y679 AUP1_HUMAN 94.878 0.995134 1.00244 AUP1 - Lipid droplet-regulating VLDL assembly factor AUP1 - Homo sapiens (Human) - AUP1 gene Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (PubMed:18711132, PubMed:21857022). Plays a role in lipid droplet formation (PubMed:21857022). Induces lipid droplet clustering (PubMed:24039768). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (PubMed:23223569, PubMed:21127063). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (PubMed:23223569). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (PubMed:28183703). Indicus|evm.model.CM009501.1.119 Q3ZBE0 DQX1_BOVIN 99.861 0.997222 1.00139 DQX1 - ATP-dependent RNA helicase DQX1 - Bos taurus (Bovine) - DQX1 gene spliceosomal complex, RNA binding Indicus|evm.model.CM009501.1.120 O43763 TLX2_HUMAN 94.366 0.992982 1.00352 TLX2 - T-cell leukemia homeobox protein 2 - Homo sapiens (Human) - TLX2 gene Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity). Indicus|evm.model.CM009501.1.121 Q2YDF9 PCGF1_BOVIN 99.614 0.992308 1.00386 PCGF1 - Polycomb group RING finger protein 1 - Bos taurus (Bovine) - PCGF1 gene Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells. Indicus|evm.model.CM009501.1.122 Q6XYB7 LBX2_HUMAN 79.293 0.989848 0.994949 LBX2 - Transcription factor LBX2 - Homo sapiens (Human) - LBX2 gene Transcription factor. Indicus|evm.model.CM009501.1.123 Q17RM4 CC142_HUMAN 75.196 0.997372 1.01467 CCDC142 - Coiled-coil domain-containing protein 142 - Homo sapiens (Human) - CCDC142 gene Indicus|evm.model.CM009501.1.124 Q2HJF1 RM53_BOVIN 100.000 0.982301 1.00893 MRPL53 - 39S ribosomal protein L53, mitochondrial precursor - Bos taurus (Bovine) - MRPL53 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Indicus|evm.model.CM009501.1.125 Q13724 MOGS_HUMAN 89.861 0.997226 0.86141 MOGS - Mannosyl-oligosaccharide glucosidase - Homo sapiens (Human) - MOGS gene Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner. Indicus|evm.model.CM009501.1.126 Q96G27 WBP1_HUMAN 85.874 0.992593 1.00372 WBP1 - WW domain-binding protein 1 - Homo sapiens (Human) - WBP1 gene WW domain binding Indicus|evm.model.CM009501.1.127 Q9C086 IN80B_HUMAN 95.787 0.949198 1.05056 INO80B - INO80 complex subunit B - Homo sapiens (Human) - INO80B gene Induces growth and cell cycle arrests at the G1 phase of the cell cycle. Indicus|evm.model.CM009501.1.128 Q9BST9 RTKN_HUMAN 90.603 0.99646 1.00355 RTKN - Rhotekin - Homo sapiens (Human) - RTKN gene Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. Indicus|evm.model.CM009501.1.129 Q9H977 WDR54_HUMAN 88.922 0.99403 1.00299 WDR54 - WD repeat-containing protein 54 - Homo sapiens (Human) - WDR54 gene When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. Indicus|evm.model.CM009501.1.130 A8NIX5 CB081_BOVIN 100.000 0.247117 1.20676 Uncharacterized protein C2orf81 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009501.1.132 Q14203 DCTN1_HUMAN 93.949 0.998425 0.99374 DCTN1 - Dynactin subunit 1 - Homo sapiens (Human) - DCTN1 gene Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). Indicus|evm.model.CM009501.1.133 Q07817 B2CL1_HUMAN 86.400 0.712644 0.746781 BCL2L1 - Bcl-2-like protein 1 - Homo sapiens (Human) - BCL2L1 gene Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Indicus|evm.model.CM009501.1.134 Q6RI88 S4A5_RAT 90.651 0.806883 0.940647 Slc4a5 - Electrogenic sodium bicarbonate cotransporter 4 - Rattus norvegicus (Rat) - Slc4a5 gene Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. Indicus|evm.model.CM009501.1.135 Q0P5C2 MTDC_BOVIN 100.000 0.994302 1.00286 MTHFD2 - Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor - Bos taurus (Bovine) - MTHFD2 gene Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. Indicus|evm.model.CM009501.1.136 Q3T1J9 MOB1A_RAT 100.000 0.990783 1.00463 Mob1a - MOB kinase activator 1A - Rattus norvegicus (Rat) - Mob1a gene Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity). Indicus|evm.model.CM009501.1.137 Q3SZ84 BOLA3_BOVIN 99.091 0.981982 1.00909 BOLA3 - BolA-like protein 3 - Bos taurus (Bovine) - BOLA3 gene Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1. Indicus|evm.model.CM009501.1.138 O43151 TET3_HUMAN 91.055 0.994643 0.935933 TET3 - Methylcytosine dioxygenase TET3 - Homo sapiens (Human) - TET3 gene Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization (PubMed:31928709). Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes (PubMed:23217707). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT (PubMed:23353889). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). Indicus|evm.model.CM009501.1.139 Q16854 DGUOK_HUMAN 84.116 0.992806 1.00361 DGUOK - Deoxyguanosine kinase, mitochondrial precursor - Homo sapiens (Human) - DGUOK gene Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:8692979, PubMed:8706825, PubMed:11687801, PubMed:17073823, PubMed:23043144). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents. Indicus|evm.model.CM009501.1.140 P63269 ACTH_RAT 94.681 0.994398 0.949468 Actg2 - Actin, gamma-enteric smooth muscle precursor - Rattus norvegicus (Rat) - Actg2 gene Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Indicus|evm.model.CM009501.1.141 O95630 STABP_HUMAN 92.217 0.946188 1.05189 STAMBP - STAM-binding protein - Homo sapiens (Human) - STAMBP gene Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Indicus|evm.model.CM009501.1.142 A6NCI8 CB078_HUMAN 68.293 0.90566 0.632321 C2orf78 - Uncharacterized protein C2orf78 - Homo sapiens (Human) - C2orf78 gene Indicus|evm.model.CM009501.1.143 Q5E999 DUS11_BOVIN 99.698 0.993976 1.00302 DUSP11 - RNA/RNP complex-1-interacting phosphatase - Bos taurus (Bovine) - DUSP11 gene Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism. Indicus|evm.model.CM009501.1.144 Q9Y3C4 TPRKB_HUMAN 89.714 0.988636 1.00571 TPRKB - EKC/KEOPS complex subunit TPRKB - Homo sapiens (Human) - TPRKB gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828). TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828). Indicus|evm.model.CM009501.1.145 Q9UHF3 NAT8B_HUMAN 68.617 0.989418 0.832599 NAT8B - Putative N-acetyltransferase 8B - Homo sapiens (Human) - NAT8B gene May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). Indicus|evm.model.CM009501.1.146 Q8TCU4 ALMS1_HUMAN 67.954 0.0674127 0.879079 ALMS1 - Alstrom syndrome protein 1 - Homo sapiens (Human) - ALMS1 gene Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. Indicus|evm.model.CM009501.1.147 Q9GL32 EGR4_BOVIN 99.585 0.995859 1.00207 EGR4 - Early growth response protein 4 - Bos taurus (Bovine) - EGR4 gene Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity). Indicus|evm.model.CM009501.1.148 Q8TF61 FBX41_HUMAN 97.463 0.96259 0.794286 FBXO41 - F-box only protein 41 - Homo sapiens (Human) - FBXO41 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009501.1.149 Q2NKZ1 TCPH_BOVIN 100.000 0.996324 1.00184 CCT7 - T-complex protein 1 subunit eta - Bos taurus (Bovine) - CCT7 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.CM009501.1.150 Q9BSG0 PADC1_HUMAN 98.936 0.989418 1.00532 PRADC1 - Protease-associated domain-containing protein 1 precursor - Homo sapiens (Human) - PRADC1 gene Plays a role in the modulation of physical activity and adiposity. Indicus|evm.model.CM009501.1.151 Q6GMV2 SMYD5_HUMAN 96.651 0.995227 1.00239 SMYD5 - SET and MYND domain-containing protein 5 - Homo sapiens (Human) - SMYD5 gene Indicus|evm.model.CM009501.1.152 Q06615 NOTO_XENLA 65.517 0.215909 1.11864 noto - Homeobox protein notochord - Xenopus laevis (African clawed frog) - noto gene Transcriptional repressor. Plays a fundamental role in notochord formation, acting within the mesodermal region. Indicus|evm.model.CM009501.1.153 P24666 PPAC_HUMAN 87.898 0.981132 1.00633 ACP1 - Low molecular weight phosphotyrosine protein phosphatase - Homo sapiens (Human) - ACP1 gene Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity. Indicus|evm.model.CM009501.1.154 Q9BXF6 RFIP5_HUMAN 89.866 0.396055 2.01838 RAB11FIP5 - Rab11 family-interacting protein 5 - Homo sapiens (Human) - RAB11FIP5 gene Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. Indicus|evm.model.CM009501.1.155 Q8TD22 SFXN5_HUMAN 92.331 0.929412 1 SFXN5 - Sideroflexin-5 - Homo sapiens (Human) - SFXN5 gene Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (PubMed:30442778). Transports citrate (By similarity). Indicus|evm.model.CM009501.1.156 Q04741 EMX1_HUMAN 98.054 0.878893 1.12451 EMX1 - Homeobox protein EMX1 - Homo sapiens (Human) - EMX1 gene Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Indicus|evm.model.CM009501.1.157 Q17QK8 SPRE_BOVIN 100.000 0.992537 1.00375 SPR - Sepiapterin reductase - Bos taurus (Bovine) - SPR gene Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. Indicus|evm.model.CM009501.1.158 Q9Y2D4 EXC6B_HUMAN 98.706 0.993565 0.958076 EXOC6B - Exocyst complex component 6B - Homo sapiens (Human) - EXOC6B gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Indicus|evm.model.CM009501.1.159 E1BHJ4 CP26B_BOVIN 100.000 0.996101 1.00195 CYP26B1 - Cytochrome P450 26B1 - Bos taurus (Bovine) - CYP26B1 gene Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (By similarity). Indicus|evm.model.CM009501.1.162 A6QQP7 DYSF_BOVIN 100.000 0.0138568 1.02753 DYSF - Dysferlin - Bos taurus (Bovine) - DYSF gene Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Indicus|evm.model.CM009501.1.163 Q14966 ZN638_HUMAN 81.424 0.998962 0.974216 ZNF638 - Zinc finger protein 638 - Homo sapiens (Human) - ZNF638 gene Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). Indicus|evm.model.CM009501.1.165 Q9ULR5 PAI2B_HUMAN 93.496 0.931298 1.06504 PAIP2B - Polyadenylate-binding protein-interacting protein 2B - Homo sapiens (Human) - PAIP2B gene Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail. Indicus|evm.model.CM009501.1.166 Q3SZM9 NAGK_BOVIN 99.419 0.994203 1.00291 NAGK - N-acetyl-D-glucosamine kinase - Bos taurus (Bovine) - NAGK gene Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity (By similarity). Indicus|evm.model.CM009501.1.167 Q58DA4 TX261_BOVIN 99.422 0.873096 1.02073 TEX261 - Protein TEX261 - Bos taurus (Bovine) - TEX261 gene COPII-coated ER to Golgi transport vesicle, integral component of endoplasmic reticulum membrane, integral component of Golgi membrane, COPII receptor activity, endoplasmic reticulum to Golgi vesicle-mediated transport Indicus|evm.model.CM009501.1.168 Q8N9V6 ANR53_HUMAN 67.556 0.825603 1.01698 ANKRD53 - Ankyrin repeat domain-containing protein 53 - Homo sapiens (Human) - ANKRD53 gene Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization. Indicus|evm.model.CM009501.1.169 P31407 VATB1_BOVIN 100.000 0.996109 1.00195 ATP6V1B1 - V-type proton ATPase subunit B, kidney isoform - Bos taurus (Bovine) - ATP6V1B1 gene Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential for the proper assembly and activity of V-ATPase (By similarity). In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification (By similarity). Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium (By similarity). Indicus|evm.model.CM009501.1.170 Q9UIW0 VAX2_HUMAN 85.172 0.989547 0.989655 VAX2 - Ventral anterior homeobox 2 - Homo sapiens (Human) - VAX2 gene Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. Indicus|evm.model.CM009501.1.171 Q9UJ71 CLC4K_HUMAN 68.997 0.987952 1.0122 CD207 - C-type lectin domain family 4 member K - Homo sapiens (Human) - CD207 gene Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. Indicus|evm.model.CM009501.1.172 Q8N1N0 CLC4F_HUMAN 60.682 0.914474 1.03226 CLEC4F - C-type lectin domain family 4 member F - Homo sapiens (Human) - CLEC4F gene Receptor with an affinity for galactose and fucose. Could be involved in endocytosis (By similarity). Indicus|evm.model.CM009501.1.173 O55208 FIGLA_MOUSE 68.033 0.607527 0.958763 Figla - Factor in the germline alpha - Mus musculus (Mouse) - Figla gene Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. Indicus|evm.model.CM009501.1.174 P35612 ADDB_HUMAN 93.846 0.982069 0.998623 ADD2 - Beta-adducin - Homo sapiens (Human) - ADD2 gene Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. Indicus|evm.model.CM009501.1.175 Q06922 TGFA_PIG 96.250 0.987578 1.00625 TGFA - Protransforming growth factor alpha precursor - Sus scrofa (Pig) - TGFA gene TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Indicus|evm.model.CM009501.1.176 Q5R8M1 STK38_PONAB 92.704 0.987234 0.505376 STK38 - Serine/threonine-protein kinase 38 - Pongo abelii (Sumatran orangutan) - STK38 gene Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). Indicus|evm.model.CM009501.1.177 A2VDV2 STK38_BOVIN 89.610 0.93865 0.350538 STK38 - Serine/threonine-protein kinase 38 - Bos taurus (Bovine) - STK38 gene Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). Indicus|evm.model.CM009501.1.178 Q2HJI3 F136A_BOVIN 100.000 0.985612 1.00725 FAM136A - Protein FAM136A - Bos taurus (Bovine) - FAM136A gene cytoplasm Indicus|evm.model.CM009501.1.179 P80457 XDH_BOVIN 99.775 0.998501 1.0015 XDH - Xanthine dehydrogenase/oxidase - Bos taurus (Bovine) - XDH gene Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Indicus|evm.model.CM009501.1.180 Q58DW5 RL5_BOVIN 100.000 0.831169 0.777778 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Indicus|evm.model.CM009501.1.181 O18765 S5A2_PIG 94.667 0.986755 0.594488 SRD5A2 - 3-oxo-5-alpha-steroid 4-dehydrogenase 2 - Sus scrofa (Pig) - SRD5A2 gene Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). Indicus|evm.model.CM009501.1.182 O18765 S5A2_PIG 88.421 0.930693 0.397638 SRD5A2 - 3-oxo-5-alpha-steroid 4-dehydrogenase 2 - Sus scrofa (Pig) - SRD5A2 gene Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). Indicus|evm.model.CM009501.1.183 Q4R6D9 MEMO1_MACFA 95.563 0.866469 1.13468 MEMO1 - Protein MEMO1 - Macaca fascicularis (Crab-eating macaque) - MEMO1 gene May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Indicus|evm.model.CM009501.1.184 Q9C005 DPY30_HUMAN 100.000 0.98 1.0101 DPY30 - Protein dpy-30 homolog - Homo sapiens (Human) - DPY30 gene As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Indicus|evm.model.CM009501.1.185 A2VDN5 SPAST_BOVIN 100.000 0.996748 1.00163 SPAST - Spastin - Bos taurus (Bovine) - SPAST gene ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches. Indicus|evm.model.CM009501.1.186 Q0VC54 ZNT6_BOVIN 94.794 0.995444 0.952278 SLC30A6 - Zinc transporter 6 - Bos taurus (Bovine) - SLC30A6 gene Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. Indicus|evm.model.CM009501.1.187 F1MHT9 NLRC4_BOVIN 98.622 0.998033 1 NLRC4 - NLR family CARD domain-containing protein 4 - Bos taurus (Bovine) - NLRC4 gene Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. Indicus|evm.model.CM009501.1.188 Q9BSR8 YIPF4_HUMAN 98.624 0.711475 1.25 YIPF4 - Protein YIPF4 - Homo sapiens (Human) - YIPF4 gene Involved in the maintenance of the Golgi structure. Indicus|evm.model.CM009501.1.189 Q9NR09 BIRC6_HUMAN 96.318 0.99959 1.00391 BIRC6 - Baculoviral IAP repeat-containing protein 6 - Homo sapiens (Human) - BIRC6 gene Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Indicus|evm.model.CM009501.1.190 Q17QZ7 TTC27_BOVIN 93.333 0.53125 0.90673 TTC27 - Tetratricopeptide repeat protein 27 - Bos taurus (Bovine) - TTC27 gene Indicus|evm.model.CM009501.1.191 Q14766 LTBP1_HUMAN 90.741 0.56383 0.0546194 LTBP1 - Latent-transforming growth factor beta-binding protein 1 precursor - Homo sapiens (Human) - LTBP1 gene Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Indicus|evm.model.CM009501.1.192 Q14766 LTBP1_HUMAN 83.250 0.899351 0.715863 LTBP1 - Latent-transforming growth factor beta-binding protein 1 precursor - Homo sapiens (Human) - LTBP1 gene Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Indicus|evm.model.CM009501.1.193 Q8IV61 GRP3_HUMAN 95.286 0.997147 1.01594 RASGRP3 - Ras guanyl-releasing protein 3 - Homo sapiens (Human) - RASGRP3 gene Guanine nucleotide exchange factor (GEF) for Ras and Rap1. Indicus|evm.model.CM009501.1.194 Q8NCA5 FA98A_HUMAN 97.110 0.996139 1 FAM98A - Protein FAM98A - Homo sapiens (Human) - FAM98A gene Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy (PubMed:28040436). Indicus|evm.model.CM009501.1.196 Q3ZCC3 TRAF6_BOVIN 100.000 0.980769 0.191882 TRAF6 - TNF receptor-associated factor 6 - Bos taurus (Bovine) - TRAF6 gene E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. Indicus|evm.model.CM009501.1.197 Q3ZCC3 TRAF6_BOVIN 98.246 0.995 0.738007 TRAF6 - TNF receptor-associated factor 6 - Bos taurus (Bovine) - TRAF6 gene E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. Indicus|evm.model.CM009501.1.200 Q9JLL0 CRIM1_MOUSE 97.273 0.77305 0.135969 Crim1 - Cysteine-rich motor neuron 1 protein precursor - Mus musculus (Mouse) - Crim1 gene May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (By similarity). Indicus|evm.model.CM009501.1.202 Q9UHY8 FEZ2_HUMAN 94.334 0.994286 0.991501 FEZ2 - Fasciculation and elongation protein zeta-2 - Homo sapiens (Human) - FEZ2 gene Involved in axonal outgrowth and fasciculation. Indicus|evm.model.CM009501.1.204 Q95LI2 VITRN_BOVIN 97.393 0.996865 0.978528 VIT - Vitrin precursor - Bos taurus (Bovine) - VIT gene Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells. Indicus|evm.model.CM009501.1.205 O43815 STRN_HUMAN 93.943 0.997531 1.03846 STRN - Striatin - Homo sapiens (Human) - STRN gene Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling. Indicus|evm.model.CM009501.1.206 Q9P2D3 HTR5B_HUMAN 97.393 0.9909 1.00821 HEATR5B - HEAT repeat-containing protein 5B - Homo sapiens (Human) - HEATR5B gene Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). Indicus|evm.model.CM009501.1.207 Q2KI19 GPT11_BOVIN 100.000 0.977358 1.01923 GPATCH11 - G patch domain-containing protein 11 - Bos taurus (Bovine) - GPATCH11 gene kinetochore Indicus|evm.model.CM009501.1.208 P19525 E2AK2_HUMAN 61.441 0.996255 0.969147 EIF2AK2 - Interferon-induced, double-stranded RNA-activated protein kinase - Homo sapiens (Human) - EIF2AK2 gene IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19507191, PubMed:19189853, PubMed:21123651, PubMed:21072047, PubMed:22948139, PubMed:23229543, PubMed:22381929). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:20171114, PubMed:19840259, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:22214662, PubMed:19229320). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). Indicus|evm.model.CM009501.1.209 Q6WG18 ST6B1_PANTR 87.417 0.990132 1.0033 SULT6B1 - Sulfotransferase 6B1 - Pan troglodytes (Chimpanzee) - SULT6B1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity). Indicus|evm.model.CM009501.1.210 Q03701 CEBPZ_HUMAN 84.166 0.993402 1.00664 CEBPZ - CCAAT/enhancer-binding protein zeta - Homo sapiens (Human) - CEBPZ gene Stimulates transcription from the HSP70 promoter. Indicus|evm.model.CM009501.1.211 Q2KHV5 NDUF7_BOVIN 99.320 0.995475 1.00227 NDUFAF7 - Protein arginine methyltransferase NDUFAF7, mitochondrial precursor - Bos taurus (Bovine) - NDUFAF7 gene Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex. Indicus|evm.model.CM009501.1.212 O94806 KPCD3_HUMAN 97.640 0.997755 1.00112 PRKD3 - Serine/threonine-protein kinase D3 - Homo sapiens (Human) - PRKD3 gene Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). Indicus|evm.model.CM009501.1.213 Q28120 QPCT_BOVIN 100.000 0.994475 1.00277 QPCT - Glutaminyl-peptide cyclotransferase precursor - Bos taurus (Bovine) - QPCT gene Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation (By similarity). Indicus|evm.model.CM009501.1.214 P62907 RL10A_RAT 82.609 0.809524 0.387097 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Indicus|evm.model.CM009501.1.215 Q9UKI2 BORG2_HUMAN 94.094 0.992157 1.00394 CDC42EP3 - Cdc42 effector protein 3 - Homo sapiens (Human) - CDC42EP3 gene Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Indicus|evm.model.CM009501.1.216 Q2TBQ7 RMD2_BOVIN 99.512 0.921171 1.08293 RMDN2 - Regulator of microtubule dynamics protein 2 - Bos taurus (Bovine) - RMDN2 gene cytoplasm, mitochondrion, mitotic spindle pole, spindle microtubule, microtubule binding Indicus|evm.model.CM009501.1.217 Q16678 CP1B1_HUMAN 81.952 0.996296 0.994475 CYP1B1 - Cytochrome P450 1B1 - Homo sapiens (Human) - CYP1B1 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant hydroxylase activity toward E2 at the C-4 position (PubMed:11555828, PubMed:12865317). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (PubMed:10426814). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376, PubMed:15258110). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed:20972997). Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (PubMed:21068195). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (PubMed:10426814). Plays an important role in retinal vascular development. Under hyperoxic O2 conditions, promotes retinal angiogenesis and capillary morphogenesis, likely by metabolizing the oxygenated products generated during the oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression (By similarity). Indicus|evm.model.CM009501.1.218 Q6PA06 ATLA2_MOUSE 97.818 0.971681 0.969125 Atl2 - Atlastin-2 - Mus musculus (Mouse) - Atl2 gene GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. Indicus|evm.model.CM009501.1.219 Q9Y2Z4 SYYM_HUMAN 50.000 0.688312 0.161426 YARS2 - Tyrosine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - YARS2 gene Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Indicus|evm.model.CM009501.1.220 Q8WVV9 HNRLL_HUMAN 99.262 0.99631 1 HNRNPLL - Heterogeneous nuclear ribonucleoprotein L-like - Homo sapiens (Human) - HNRNPLL gene RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. Indicus|evm.model.CM009501.1.221 Q58DT1 RL7_BOVIN 98.256 0.988439 0.697581 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Indicus|evm.model.CM009501.1.222 Q5EA79 GALM_BOVIN 100.000 0.994169 1.00292 GALM - Galactose mutarotase - Bos taurus (Bovine) - GALM gene Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose. Indicus|evm.model.CM009501.1.223 Q3T106 SRSF7_BOVIN 98.739 0.991632 1.01702 SRSF7 - Serine/arginine-rich splicing factor 7 - Bos taurus (Bovine) - SRSF7 gene Required for pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific (By similarity). Indicus|evm.model.CM009501.1.224 Q5XHH9 TT39B_XENLA 48.348 0.981002 0.988055 ttc39b - Tetratricopeptide repeat protein 39B - Xenopus laevis (African clawed frog) - ttc39b gene May be involved in lipid metabolism. Indicus|evm.model.CM009501.1.225 Q2KHW8 GEMI6_BOVIN 100.000 0.988024 1.00602 GEMIN6 - Gem-associated protein 6 - Bos taurus (Bovine) - GEMIN6 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity). Indicus|evm.model.CM009501.1.226 Q6P158 DHX57_HUMAN 91.765 0.978324 0.998557 DHX57 - Putative ATP-dependent RNA helicase DHX57 - Homo sapiens (Human) - DHX57 gene Probable ATP-binding RNA helicase. Indicus|evm.model.CM009501.1.227 Q8BW86 ARG33_MOUSE 91.549 0.0770925 1.06824 Arhgef33 - Rho guanine nucleotide exchange factor 33 - Mus musculus (Mouse) - Arhgef33 gene Indicus|evm.model.CM009501.1.228 Q07889 SOS1_HUMAN 99.325 0.925643 1.07952 SOS1 - Son of sevenless homolog 1 - Homo sapiens (Human) - SOS1 gene Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). Indicus|evm.model.CM009501.1.229 Q5MAI5 CDKL4_HUMAN 87.055 0.888889 0.831135 CDKL4 - Cyclin-dependent kinase-like 4 - Homo sapiens (Human) - CDKL4 gene nucleus, cyclin-dependent protein serine/threonine kinase activity, protein phosphorylation Indicus|evm.model.CM009501.1.230 Q8IVH8 M4K3_HUMAN 96.685 0.998158 0.607383 MAP4K3 - Mitogen-activated protein kinase kinase kinase kinase 3 - Homo sapiens (Human) - MAP4K3 gene May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Indicus|evm.model.CM009501.1.231 Q8NBL3 T178A_HUMAN 99.327 0.993289 1.00337 TMEM178A - Transmembrane protein 178A precursor - Homo sapiens (Human) - TMEM178A gene Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. Indicus|evm.model.CM009501.1.232 Q9BTF0 THUM2_HUMAN 75.697 0.994024 0.998012 THUMPD2 - THUMP domain-containing protein 2 - Homo sapiens (Human) - THUMPD2 gene tRNA (guanine) methyltransferase activity, tRNA methylation Indicus|evm.model.CM009501.1.233 P50502 F10A1_HUMAN 66.000 0.982301 0.306233 ST13 - Hsc70-interacting protein - Homo sapiens (Human) - ST13 gene One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). Indicus|evm.model.CM009501.1.234 Q8NFI4 F10A5_HUMAN 81.818 0.966667 0.243902 ST13P5 - Putative protein FAM10A5 - Homo sapiens (Human) - ST13P5 gene heat shock protein binding, chaperone cofactor-dependent protein refolding, protein-containing complex assembly Indicus|evm.model.CM009501.1.236 Q5EAB0 MPZL2_BOVIN 84.906 0.693333 0.348837 MPZL2 - Myelin protein zero-like protein 2 precursor - Bos taurus (Bovine) - MPZL2 gene Mediates homophilic cell-cell adhesion. Indicus|evm.model.CM009501.1.237 Q5EAB0 MPZL2_BOVIN 85.000 0.907692 0.302326 MPZL2 - Myelin protein zero-like protein 2 precursor - Bos taurus (Bovine) - MPZL2 gene Mediates homophilic cell-cell adhesion. Indicus|evm.model.CM009501.1.238 Q3T171 RL36_BOVIN 81.481 0.91954 0.828571 RPL36 - 60S ribosomal protein L36 - Bos taurus (Bovine) - RPL36 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009501.1.239 Q504Y2 PKDCC_HUMAN 94.872 0.988701 0.718053 PKDCC - Extracellular tyrosine-protein kinase PKDCC precursor - Homo sapiens (Human) - PKDCC gene Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity). Indicus|evm.model.CM009501.1.240 Q9HC35 EMAL4_HUMAN 92.214 0.994965 1.01223 EML4 - Echinoderm microtubule-associated protein-like 4 - Homo sapiens (Human) - EML4 gene Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). Indicus|evm.model.CM009501.1.241 Q3T061 COX7R_BOVIN 100.000 0.982609 1.00877 COX7A2L - Cytochrome c oxidase subunit 7A-related protein, mitochondrial precursor - Bos taurus (Bovine) - COX7A2L gene Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity). Indicus|evm.model.CM009501.1.242 Q71U34 HSP7C_SAGOE 82.292 0.618421 0.235294 HSPA8 - Heat shock cognate 71 kDa protein - Saguinus oedipus (Cotton-top tamarin) - HSPA8 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Indicus|evm.model.CM009501.1.243 Q8R523 KCNG3_RAT 98.198 0.924686 0.551963 Kcng3 - Potassium voltage-gated channel subfamily G member 3 - Rattus norvegicus (Rat) - Kcng3 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Indicus|evm.model.CM009501.1.244 Q8TAE7 KCNG3_HUMAN 97.015 0.985185 0.309633 KCNG3 - Potassium voltage-gated channel subfamily G member 3 - Homo sapiens (Human) - KCNG3 gene Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135). Indicus|evm.model.CM009501.1.245 A6QL72 MTA3_BOVIN 99.308 0.924679 1.05763 MTA3 - Metastasis-associated protein MTA3 - Bos taurus (Bovine) - MTA3 gene Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6 (By similarity). Indicus|evm.model.CM009501.1.246 Q8TDS5 OXER1_HUMAN 72.857 0.905013 0.895981 OXER1 - Oxoeicosanoid receptor 1 - Homo sapiens (Human) - OXER1 gene Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins. Indicus|evm.model.CM009501.1.249 Q0VCA8 3HAO_BOVIN 100.000 0.685096 1.45455 HAAO - 3-hydroxyanthranilate 3,4-dioxygenase - Bos taurus (Bovine) - HAAO gene Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Indicus|evm.model.CM009501.1.252 P47974 TISD_HUMAN 95.142 0.995885 0.983806 ZFP36L2 - mRNA decay activator protein ZFP36L2 - Homo sapiens (Human) - ZFP36L2 gene Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. Indicus|evm.model.CM009501.1.253 A8C750 THADA_CANLF 86.154 0.998459 0.999487 THADA - Thyroid adenoma-associated protein homolog - Canis lupus familiaris (Dog) - THADA gene cytosol, tRNA methylation Indicus|evm.model.CM009501.1.254 Q8IVE3 PKHH2_HUMAN 93.503 0.99866 0.99933 PLEKHH2 - Pleckstrin homology domain-containing family H member 2 - Homo sapiens (Human) - PLEKHH2 gene In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia. Indicus|evm.model.CM009501.1.255 Q32KV4 DC2L1_BOVIN 100.000 0.994318 1.00285 DYNC2LI1 - Cytoplasmic dynein 2 light intermediate chain 1 - Bos taurus (Bovine) - DYNC2LI1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles. Involved in the regulation of ciliary length. Indicus|evm.model.CM009501.1.256 Q9H222 ABCG5_HUMAN 81.004 0.908347 0.938556 ABCG5 - ATP-binding cassette sub-family G member 5 - Homo sapiens (Human) - ABCG5 gene ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11138003, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11138003, PubMed:15054092). The heterodimer with ABCG8 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356). Indicus|evm.model.CM009501.1.257 Q9H221 ABCG8_HUMAN 82.196 0.997019 0.997028 ABCG8 - ATP-binding cassette sub-family G member 8 - Homo sapiens (Human) - ABCG8 gene ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356). Indicus|evm.model.CM009501.1.258 P42704 LPPRC_HUMAN 80.603 0.996408 0.998565 LRPPRC - Leucine-rich PPR motif-containing protein, mitochondrial precursor - Homo sapiens (Human) - LRPPRC gene May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Indicus|evm.model.CM009501.1.259 O62830 PPM1B_BOVIN 98.760 0.995833 0.991736 PPM1B - Protein phosphatase 1B - Bos taurus (Bovine) - PPM1B gene Enzyme with a broad specificity. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). Indicus|evm.model.CM009501.1.260 Q07837 SLC31_HUMAN 82.336 0.997085 1.00146 SLC3A1 - Neutral and basic amino acid transport protein rBAT - Homo sapiens (Human) - SLC3A1 gene Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule. Indicus|evm.model.CM009501.1.261 Q5RAK4 PPCEL_PONAB 90.041 0.997275 1.00963 PREPL - Prolyl endopeptidase-like - Pongo abelii (Sumatran orangutan) - PREPL gene Serine peptidase whose precise substrate specificity remains unclear (By similarity). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (By similarity). May play a role in the regulation of synaptic vesicle exocytosis (By similarity). Indicus|evm.model.CM009501.1.262 Q7Z624 CMKMT_HUMAN 76.984 0.919118 0.421053 CAMKMT - Calmodulin-lysine N-methyltransferase - Homo sapiens (Human) - CAMKMT gene Catalyzes the trimethylation of 'Lys-116' in calmodulin. Indicus|evm.model.CM009501.1.263 Q7Z624 CMKMT_HUMAN 74.432 0.881657 0.52322 CAMKMT - Calmodulin-lysine N-methyltransferase - Homo sapiens (Human) - CAMKMT gene Catalyzes the trimethylation of 'Lys-116' in calmodulin. Indicus|evm.model.CM009501.1.264 O95343 SIX3_HUMAN 100.000 0.992157 0.768072 SIX3 - Homeobox protein SIX3 - Homo sapiens (Human) - SIX3 gene Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway. Indicus|evm.model.CM009501.1.265 Q62232 SIX2_MOUSE 98.322 0.993311 1.01014 Six2 - Homeobox protein SIX2 - Mus musculus (Mouse) - Six2 gene Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation (PubMed:20515681). During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1 (PubMed:19660448). During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway (PubMed:18321982). Also may be involved in limb tendon and ligament development (PubMed:7720577). Plays a role in cell proliferation and migration (By similarity). Indicus|evm.model.CM009501.1.267 Q8N5C6 SRBD1_HUMAN 83.551 0.98029 0.968844 SRBD1 - S1 RNA-binding domain-containing protein 1 - Homo sapiens (Human) - SRBD1 gene mRNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009501.1.268 Q02156 KPCE_HUMAN 99.186 0.99729 1.00136 PRKCE - Protein kinase C epsilon type - Homo sapiens (Human) - PRKCE gene Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Indicus|evm.model.CM009501.1.269 Q99814 EPAS1_HUMAN 86.797 0.997704 1.00115 EPAS1 - Endothelial PAS domain-containing protein 1 - Homo sapiens (Human) - EPAS1 gene Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). Indicus|evm.model.CM009501.1.270 Q2YDG1 TM247_BOVIN 98.101 0.912791 0.792627 Transmembrane protein 247 - Bos taurus (Bovine) Indicus|evm.model.CM009501.1.271 Q32LB7 VATE2_BOVIN 100.000 0.991189 1.00442 ATP6V1E2 - V-type proton ATPase subunit E 2 - Bos taurus (Bovine) - ATP6V1E2 gene Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). Indicus|evm.model.CM009501.1.272 P17081 RHOQ_HUMAN 100.000 0.988889 0.878049 RHOQ - Rho-related GTP-binding protein RhoQ precursor - Homo sapiens (Human) - RHOQ gene Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. Indicus|evm.model.CM009501.1.273 Q07326 PIGF_HUMAN 90.411 0.990909 1.00457 PIGF - Phosphatidylinositol-glycan biosynthesis class F protein - Homo sapiens (Human) - PIGF gene Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI. Indicus|evm.model.CM009501.1.274 Q9P021 CRIPT_HUMAN 100.000 0.980392 1.0099 CRIPT - Cysteine-rich PDZ-binding protein - Homo sapiens (Human) - CRIPT gene Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. Indicus|evm.model.CM009501.1.275 Q29RN6 SOCS5_BOVIN 99.813 0.996276 1.00187 SOCS5 - Suppressor of cytokine signaling 5 - Bos taurus (Bovine) - SOCS5 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling (By similarity). Indicus|evm.model.CM009501.1.276 Q5R8Z6 MCFD2_PONAB 92.568 0.73 1.36986 MCFD2 - Multiple coagulation factor deficiency protein 2 homolog precursor - Pongo abelii (Sumatran orangutan) - MCFD2 gene The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Indicus|evm.model.CM009501.1.277 Q9ULT0 TTC7A_HUMAN 92.890 0.997672 1.00117 TTC7A - Tetratricopeptide repeat protein 7A - Homo sapiens (Human) - TTC7A gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity). Indicus|evm.model.CM009501.1.278 P0DP31 CALM3_RAT 95.973 0.381443 2.60403 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Indicus|evm.model.CM009501.1.279 Q3T0L5 EPCAM_BOVIN 99.045 0.993651 1.00318 EPCAM - Epithelial cell adhesion molecule precursor - Bos taurus (Bovine) - EPCAM gene May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Indicus|evm.model.CM009501.1.280 Q3MHE4 MSH2_BOVIN 99.893 0.997861 1.00107 MSH2 - DNA mismatch repair protein Msh2 - Bos taurus (Bovine) - MSH2 gene Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. Indicus|evm.model.CM009501.1.281 Q9ERS1 KCNKC_RAT 97.756 0.873596 0.827907 Kcnk12 - Potassium channel subfamily K member 12 - Rattus norvegicus (Rat) - Kcnk12 gene Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel. Indicus|evm.model.CM009501.1.282 P52701 MSH6_HUMAN 91.856 0.998532 1.00147 MSH6 - DNA mismatch repair protein Msh6 - Homo sapiens (Human) - MSH6 gene Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. Indicus|evm.model.CM009501.1.283 Q7TPD1 FBX11_MOUSE 99.882 0.960407 0.950538 Fbxo11 - F-box only protein 11 - Mus musculus (Mouse) - Fbxo11 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. Indicus|evm.model.CM009501.1.284 P62752 RL23A_RAT 63.636 0.857143 0.628205 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009501.1.286 P32314 FOXN2_HUMAN 91.344 0.995455 1.02088 FOXN2 - Forkhead box protein N2 - Homo sapiens (Human) - FOXN2 gene Binds to the purine-rich region in HTLV-I LTR. Indicus|evm.model.CM009501.1.287 Q6ZMI0 PPR21_HUMAN 94.872 0.997439 1.00128 PPP1R21 - Protein phosphatase 1 regulatory subunit 21 - Homo sapiens (Human) - PPP1R21 gene Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (PubMed:30520571). Indicus|evm.model.CM009501.1.288 Q9Y6Q2 STON1_HUMAN 87.457 0.996552 0.789116 STON1 - Stonin-1 - Homo sapiens (Human) - STON1 gene May be involved in the endocytic machinery. Indicus|evm.model.CM009501.1.289 Q9UNN4 TF2AY_HUMAN 80.738 0.546067 0.930962 GTF2A1L - TFIIA-alpha and beta-like factor - Homo sapiens (Human) - GTF2A1L gene May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. Indicus|evm.model.CM009501.1.290 Q28005 LSHR_BOVIN 96.434 0.99705 0.96719 LHCGR - Lutropin-choriogonadotropic hormone receptor precursor - Bos taurus (Bovine) - LHCGR gene Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Indicus|evm.model.CM009501.1.291 P35376 FSHR_BOVIN 99.379 0.996899 0.928058 FSHR - Follicle-stimulating hormone receptor precursor - Bos taurus (Bovine) - FSHR gene G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. Indicus|evm.model.CM009501.1.292 Q9ULB1 NRX1A_HUMAN 96.277 0.999127 0.77522 NRXN1 - Neurexin-1 precursor - Homo sapiens (Human) - NRXN1 gene Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity). Indicus|evm.model.CM009501.1.293 Q4L180 FIL1L_HUMAN 95.906 0.965909 0.155066 FILIP1L - Filamin A-interacting protein 1-like - Homo sapiens (Human) - FILIP1L gene Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. Indicus|evm.model.CM009501.1.294 Q96MG7 NSE3_HUMAN 77.863 0.909091 0.470395 NSMCE3 - Non-structural maintenance of chromosomes element 3 homolog - Homo sapiens (Human) - NSMCE3 gene Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). Indicus|evm.model.CM009501.1.295 Q9CPR8 NSE3_MOUSE 60.550 0.981308 0.383513 Nsmce3 - Non-structural maintenance of chromosomes element 3 homolog - Mus musculus (Mouse) - Nsmce3 gene Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (PubMed:14593116). Indicus|evm.model.CM009501.1.297 Q96FN9 DTD2_HUMAN 89.286 0.988166 1.00595 DTD2 - D-aminoacyl-tRNA deacylase 2 - Homo sapiens (Human) - DTD2 gene Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity). Indicus|evm.model.CM009501.1.298 Q08DV6 ASB3_BOVIN 99.810 0.996198 1.0019 ASB3 - Ankyrin repeat and SOCS box protein 3 - Bos taurus (Bovine) - ASB3 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B (By similarity). Indicus|evm.model.CM009501.1.299 Q9CQG1 CHAC2_MOUSE 94.382 0.936508 1.0618 Chac2 - Putative glutathione-specific gamma-glutamylcyclotransferase 2 - Mus musculus (Mouse) - Chac2 gene Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide (PubMed:27913623). Acts specifically on glutathione, but not on other gamma-glutamyl peptides (By similarity). Indicus|evm.model.CM009501.1.300 Q5R8S4 ERLEC_PONAB 97.101 0.995868 1.00207 ERLEC1 - Endoplasmic reticulum lectin 1 precursor - Pongo abelii (Sumatran orangutan) - ERLEC1 gene Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins (By similarity). Indicus|evm.model.CM009501.1.301 O95800 GPR75_HUMAN 93.889 0.91511 1.09074 GPR75 - Probable G-protein coupled receptor 75 - Homo sapiens (Human) - GPR75 gene G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. Indicus|evm.model.CM009501.1.302 F1MKX4 PSME4_BOVIN 99.675 0.998915 0.999458 PSME4 - Proteasome activator complex subunit 4 - Bos taurus (Bovine) - PSME4 gene Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks (By similarity). Indicus|evm.model.CM009501.1.303 P07033 ACYP2_BOVIN 73.134 0.815951 1.64646 ACYP2 - Acylphosphatase-2 - Bos taurus (Bovine) - ACYP2 gene Its physiological role is not yet clear. Indicus|evm.model.CM009501.1.304 A6QQL5 CB073_BOVIN 99.310 0.993127 1.00345 Uncharacterized protein C2orf73 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009501.1.305 Q01082 SPTB2_HUMAN 99.027 0.999154 1 SPTBN1 - Spectrin beta chain, non-erythrocytic 1 - Homo sapiens (Human) - SPTBN1 gene Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Indicus|evm.model.CM009501.1.306 Q6ZMW3 EMAL6_HUMAN 97.957 0.998979 1.00051 EML6 - Echinoderm microtubule-associated protein-like 6 - Homo sapiens (Human) - EML6 gene May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. Indicus|evm.model.CM009501.1.307 Q9NQC3 RTN4_HUMAN 80.699 0.998308 0.991611 RTN4 - Reticulon-4 - Homo sapiens (Human) - RTN4 gene Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:27619977, PubMed:25612671, PubMed:24262037). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977, PubMed:25612671, PubMed:24262037, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). Indicus|evm.model.CM009501.1.308 Q4R6I5 CLHC1_MACFA 80.245 0.933007 1.04437 CLHC1 - Clathrin heavy chain linker domain-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - CLHC1 gene Indicus|evm.model.CM009501.1.309 P62979 RS27A_HUMAN 100.000 0.987261 1.00641 RPS27A - Ubiquitin-40S ribosomal protein S27a precursor - Homo sapiens (Human) - RPS27A gene Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Indicus|evm.model.CM009501.1.310 P46198 IF2M_BOVIN 99.587 0.997253 1.00138 MTIF2 - Translation initiation factor IF-2, mitochondrial precursor - Bos taurus (Bovine) - MTIF2 gene One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. Indicus|evm.model.CM009501.1.311 A1A4Q2 PRXD1_BOVIN 100.000 0.651341 1.52632 PRORSD1 - Prolyl-tRNA synthetase associated domain-containing protein 1 - Bos taurus (Bovine) - PRORSD1 gene Indicus|evm.model.CM009501.1.312 Q3V6T2 GRDN_HUMAN 95.998 0.99893 0.999466 CCDC88A - Girdin - Homo sapiens (Human) - CCDC88A gene Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:20462955, PubMed:16139227, PubMed:19211784, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). Indicus|evm.model.CM009501.1.313 Q3ZC62 CFA36_BOVIN 91.254 0.994186 1.09904 CFAP36 - Cilia- and flagella-associated protein 36 - Bos taurus (Bovine) - CFAP36 gene May act as an effector for ARL3. Indicus|evm.model.CM009501.1.314 Q922R5 P4R3B_MOUSE 96.585 0.997564 1.00122 Ppp4r3b - Serine/threonine-protein phosphatase 4 regulatory subunit 3B - Mus musculus (Mouse) - Ppp4r3b gene Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers (By similarity). Indicus|evm.model.CM009501.1.315 Q8TCS8 PNPT1_HUMAN 91.816 0.996173 1.00128 PNPT1 - Polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor - Homo sapiens (Human) - PNPT1 gene RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA. Indicus|evm.model.CM009501.1.316 Q7YQD7 FBLN3_MACFA 92.510 0.995927 0.995943 EFEMP1 - EGF-containing fibulin-like extracellular matrix protein 1 precursor - Macaca fascicularis (Crab-eating macaque) - EFEMP1 gene Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (By similarity). Indicus|evm.model.CM009501.1.317 Q96PX6 CC85A_HUMAN 96.667 0.0672854 0.779385 CCDC85A - Coiled-coil domain-containing protein 85A - Homo sapiens (Human) - CCDC85A gene May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family. Indicus|evm.model.CM009501.1.319 Q86Y07 VRK2_HUMAN 74.539 0.898671 1.18504 VRK2 - Serine/threonine-protein kinase VRK2 - Homo sapiens (Human) - VRK2 gene Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant. Indicus|evm.model.CM009501.1.320 Q9NW38 FANCL_HUMAN 87.701 0.992 1 FANCL - E3 ubiquitin-protein ligase FANCL - Homo sapiens (Human) - FANCL gene Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. Indicus|evm.model.CM009501.1.321 Q32L48 H2B1N_BOVIN 94.444 0.962963 0.428571 H2BC15 - Histone H2B type 1-N - Bos taurus (Bovine) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009501.1.323 Q5E9S8 CDIN1_BOVIN 89.535 0.977011 0.309609 CDIN1 - CDAN1-interacting nuclease 1 - Bos taurus (Bovine) - CDIN1 gene Plays a role in erythroid cell differentiation. Indicus|evm.model.CM009501.1.324 Q9H165 BC11A_HUMAN 99.641 0.997608 1.0012 BCL11A - B-cell lymphoma/leukemia 11A - Homo sapiens (Human) - BCL11A gene Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). Indicus|evm.model.CM009501.1.325 Q9BWT3 PAPOG_HUMAN 94.602 0.997301 1.00679 PAPOLG - Poly(A) polymerase gamma - Homo sapiens (Human) - PAPOLG gene Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. Indicus|evm.model.CM009501.1.326 Q04864 REL_HUMAN 79.936 0.993243 0.956381 REL - Proto-oncogene c-Rel - Homo sapiens (Human) - REL gene Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. Indicus|evm.model.CM009501.1.327 Q3MIT2 PUS10_HUMAN 74.229 0.902309 1.06427 PUS10 - tRNA pseudouridine synthase Pus10 - Homo sapiens (Human) - PUS10 gene Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm (PubMed:31819270). In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs (PubMed:30530625, PubMed:31819270). tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs (PubMed:30530625). In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity (PubMed:31819270). Binds pri-miRNAs (PubMed:31819270). Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage (PubMed:14527409, PubMed:19712588). Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (PubMed:19712588). Indicus|evm.model.CM009501.1.328 Q0P5B1 PEX13_BOVIN 99.752 0.99505 1.00248 PEX13 - Peroxisomal membrane protein PEX13 - Bos taurus (Bovine) - PEX13 gene Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity). Indicus|evm.model.CM009501.1.329 Q6NSI8 K1841_HUMAN 93.750 0.940678 0.164345 KIAA1841 - Uncharacterized protein KIAA1841 - Homo sapiens (Human) - KIAA1841 gene Indicus|evm.model.CM009501.1.330 Q6NSI8 K1841_HUMAN 90.722 0.995876 0.675487 KIAA1841 - Uncharacterized protein KIAA1841 - Homo sapiens (Human) - KIAA1841 gene Indicus|evm.model.CM009501.1.331 P16383 GCFC2_HUMAN 77.395 0.994891 1.00256 GCFC2 - Intron Large complex component GCFC2 - Homo sapiens (Human) - GCFC2 gene Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). Indicus|evm.model.CM009501.1.332 Q2HJI0 RM19_BOVIN 98.973 0.993174 1.00342 MRPL19 - 39S ribosomal protein L19, mitochondrial precursor - Bos taurus (Bovine) - MRPL19 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009501.1.333 P10096 G3P_BOVIN 75.976 0.992908 0.846847 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Bos taurus (Bovine) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Indicus|evm.model.CM009501.1.334 Q9H8M9 EVA1A_HUMAN 86.525 0.985816 0.927632 EVA1A - Protein eva-1 homolog A - Homo sapiens (Human) - EVA1A gene Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis. Indicus|evm.model.CM009501.1.335 Q53LP3 SWAHC_HUMAN 81.818 0.669251 0.737143 SOWAHC - Ankyrin repeat domain-containing protein SOWAHC - Homo sapiens (Human) - SOWAHC gene Indicus|evm.model.CM009501.1.336 Q2KJB1 SEP10_BOVIN 100.000 0.897541 1.07726 SEPTIN10 - Septin-10 - Bos taurus (Bovine) - SEPTIN10 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Indicus|evm.model.CM009501.1.337 Q8TEJ3 SH3R3_HUMAN 75.429 0.899204 0.854875 SH3RF3 - E3 ubiquitin-protein ligase SH3RF3 - Homo sapiens (Human) - SH3RF3 gene Has E3 ubiquitin-protein ligase activity. Indicus|evm.model.CM009501.1.338 Q6NRD3 SH3R1_XENLA 84.058 0.653846 0.125908 sh3rf1 - E3 ubiquitin-protein ligase SH3RF1 - Xenopus laevis (African clawed frog) - sh3rf1 gene Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway (By similarity). Plays an essential role in the anterior neural development. Indicus|evm.model.CM009501.1.339 Q9UNE0 EDAR_HUMAN 83.964 0.995444 0.979911 EDAR - Tumor necrosis factor receptor superfamily member EDAR precursor - Homo sapiens (Human) - EDAR gene Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. Indicus|evm.model.CM009501.1.340 Q95JJ5 CC138_MACFA 75.749 0.923505 1.0812 CCDC138 - Coiled-coil domain-containing protein 138 - Macaca fascicularis (Crab-eating macaque) - CCDC138 gene Indicus|evm.model.CM009501.1.341 P48820 RBP2_BOVIN 99.816 0.351492 2.8424 RANBP2 - E3 SUMO-protein ligase RanBP2 - Bos taurus (Bovine) - RANBP2 gene E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. Indicus|evm.model.CM009501.1.342 P48059 LIMS1_HUMAN 98.154 0.757009 1.31692 LIMS1 - LIM and senescent cell antigen-like-containing domain protein 1 - Homo sapiens (Human) - LIMS1 gene Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. Indicus|evm.model.CM009501.1.343 Q99666 RGPD5_HUMAN 78.767 0.0848665 0.954674 RGPD5 - RANBP2-like and GRIP domain-containing protein 5/6 - Homo sapiens (Human) - RGPD5 gene cytoplasm, nuclear pore, NLS-bearing protein import into nucleus Indicus|evm.model.CM009501.1.344 O75897 ST1C4_HUMAN 70.134 0.989761 0.970199 SULT1C4 - Sulfotransferase 1C4 - Homo sapiens (Human) - SULT1C4 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). Indicus|evm.model.CM009501.1.345 O75897 ST1C4_HUMAN 79.461 0.989967 0.990066 SULT1C4 - Sulfotransferase 1C4 - Homo sapiens (Human) - SULT1C4 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). Indicus|evm.model.CM009501.1.346 P50237 ST1C1_RAT 63.889 0.486111 0.236842 Sult1c1 - Sulfotransferase 1C1 - Rattus norvegicus (Rat) - Sult1c1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines (By similarity). Indicus|evm.model.CM009501.1.347 Q9WUW8 ST1C2_RAT 79.791 0.966216 1 Sult1c2 - Sulfotransferase 1C2 - Rattus norvegicus (Rat) - Sult1c2 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. Indicus|evm.model.CM009501.1.348 P50237 ST1C1_RAT 86.513 0.993443 1.00329 Sult1c1 - Sulfotransferase 1C1 - Rattus norvegicus (Rat) - Sult1c1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines (By similarity). Indicus|evm.model.CM009501.1.349 Q9GZV3 SC5A7_HUMAN 90.517 0.996558 1.00172 SLC5A7 - High affinity choline transporter 1 - Homo sapiens (Human) - SLC5A7 gene Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent. Indicus|evm.model.CM009501.1.352 A5D7T4 SIAT2_BOVIN 97.778 0.995968 1.00202 ST6GAL2 - Beta-galactoside alpha-2,6-sialyltransferase 2 - Bos taurus (Bovine) - ST6GAL2 gene Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids. Indicus|evm.model.CM009501.1.354 Q9TT91 MKRN1_MACEU 82.550 0.732673 0.422594 MKRN1 - E3 ubiquitin-protein ligase makorin-1 - Macropus eugenii (Tammar wallaby) - MKRN1 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. Indicus|evm.model.CM009501.1.355 Q5R885 UXS1_PONAB 97.900 0.994764 0.909524 UXS1 - UDP-glucuronic acid decarboxylase 1 - Pongo abelii (Sumatran orangutan) - UXS1 gene Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). Indicus|evm.model.CM009501.1.356 Q32KM8 AUGN_BOVIN 98.639 0.986486 1.0068 ECRG4 - Augurin precursor - Bos taurus (Bovine) - ECRG4 gene Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity). Indicus|evm.model.CM009501.1.357 Q9DCR2 AP3S1_MOUSE 81.250 0.485893 1.65285 Ap3s1 - AP-3 complex subunit sigma-1 - Mus musculus (Mouse) - Ap3s1 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Indicus|evm.model.CM009501.1.358 O43639 NCK2_HUMAN 89.474 0.994695 0.992105 NCK2 - Cytoplasmic protein NCK2 - Homo sapiens (Human) - NCK2 gene Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Indicus|evm.model.CM009501.1.359 Q6AYZ1 TBA1C_RAT 55.850 0.991329 0.770601 Tuba1c - Tubulin alpha-1C chain - Rattus norvegicus (Rat) - Tuba1c gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009501.1.362 P38584 TTL_BOVIN 99.469 0.994709 1.00265 TTL - Tubulin--tyrosine ligase - Bos taurus (Bovine) - TTL gene Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. Indicus|evm.model.CM009501.1.363 Q5REE8 RPA2_PONAB 93.838 0.998239 1 POLR1B - DNA-directed RNA polymerase I subunit RPA2 - Pongo abelii (Sumatran orangutan) - POLR1B gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Indicus|evm.model.CM009501.1.364 Q9BSY4 CHCH5_HUMAN 86.239 0.5625 1.74545 CHCHD5 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 - Homo sapiens (Human) - CHCHD5 gene mitochondrion Indicus|evm.model.CM009501.1.365 O97596 S20A1_FELCA 96.833 0.970674 1.00147 Slc20a1 - Sodium-dependent phosphate transporter 1 - Felis catus (Cat) - Slc20a1 gene Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Indicus|evm.model.CM009501.1.366 Q86YG4 NT5D4_HUMAN 59.688 0.881235 0.983645 NT5DC4 - 5'-nucleotidase domain-containing protein 4 - Homo sapiens (Human) - NT5DC4 gene 5'-nucleotidase activity Indicus|evm.model.CM009501.1.367 A5PK21 CKP2L_BOVIN 99.731 0.963684 1.03629 CKAP2L - Cytoskeleton-associated protein 2-like - Bos taurus (Bovine) - CKAP2L gene Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells. Indicus|evm.model.CM009501.1.368 P08831 IL1A_BOVIN 99.627 0.917526 1.08582 IL1A - Interleukin-1 alpha precursor - Bos taurus (Bovine) - IL1A gene Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Indicus|evm.model.CM009501.1.369 P84089 ERH_MOUSE 98.077 0.980952 1.00962 Erh - Enhancer of rudimentary homolog - Mus musculus (Mouse) - Erh gene May have a role in the cell cycle. Indicus|evm.model.CM009501.1.370 P09428 IL1B_BOVIN 99.624 0.992509 1.00376 IL1B - Interleukin-1 beta precursor - Bos taurus (Bovine) - IL1B gene Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Indicus|evm.model.CM009501.1.371 Q9NZH6 IL37_HUMAN 61.650 0.990291 0.944954 IL37 - Interleukin-37 precursor - Homo sapiens (Human) - IL37 gene Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. Indicus|evm.model.CM009501.1.372 Q9NZH8 IL36G_HUMAN 64.596 0.902857 1.0355 IL36G - Interleukin-36 gamma precursor - Homo sapiens (Human) - IL36G gene Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. Indicus|evm.model.CM009501.1.373 Q9UHA7 IL36A_HUMAN 70.833 0.798883 1.13291 IL36A - Interleukin-36 alpha precursor - Homo sapiens (Human) - IL36A gene Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung. Indicus|evm.model.CM009501.1.374 Q9NZH7 IL36B_HUMAN 63.529 0.528302 0.969512 IL36B - Interleukin-36 beta precursor - Homo sapiens (Human) - IL36B gene Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. Indicus|evm.model.CM009501.1.375 Q9UBH0 I36RA_HUMAN 84.516 0.987179 1.00645 IL36RN - Interleukin-36 receptor antagonist protein - Homo sapiens (Human) - IL36RN gene Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. Indicus|evm.model.CM009501.1.376 Q8WWZ1 IL1FA_HUMAN 86.093 0.980392 1.00658 IL1F10 - Interleukin-1 family member 10 - Homo sapiens (Human) - IL1F10 gene Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2. Indicus|evm.model.CM009501.1.377 O77482 IL1RA_BOVIN 100.000 0.988571 1.00575 IL1RN - Interleukin-1 receptor antagonist protein precursor - Bos taurus (Bovine) - IL1RN gene Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Indicus|evm.model.CM009501.1.378 Q8NDX1 PSD4_HUMAN 71.349 0.998043 0.967803 PSD4 - PH and SEC7 domain-containing protein 4 - Homo sapiens (Human) - PSD4 gene Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. Indicus|evm.model.CM009501.1.379 P47240 PAX8_CANLF 98.475 0.995633 0.997821 PAX8 - Paired box protein Pax-8 - Canis lupus familiaris (Dog) - PAX8 gene Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development. Indicus|evm.model.CM009501.1.381 P62268 RS23_RAT 95.804 0.986111 1.00699 Rps23 - 40S ribosomal protein S23 - Rattus norvegicus (Rat) - Rps23 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Indicus|evm.model.CM009501.1.382 P04432 KVD39_HUMAN 78.788 0.784 1.06838 IGKV1D-39 - Immunoglobulin kappa variable 1D-39 precursor - Homo sapiens (Human) - IGKV1D-39 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Indicus|evm.model.CM009501.1.383 A0A0A0MRZ8 KVD11_HUMAN 55.435 0.771186 1.02609 IGKV3D-11 - Immunoglobulin kappa variable 3D-11 precursor - Homo sapiens (Human) - IGKV3D-11 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Indicus|evm.model.CM009501.1.384 P01834 IGKC_HUMAN 59.048 0.920354 1.05607 IGKC - Immunoglobulin kappa constant - Homo sapiens (Human) - IGKC gene Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009501.1.385 O43482 MS18B_HUMAN 71.569 0.933333 0.458515 OIP5 - Protein Mis18-beta - Homo sapiens (Human) - OIP5 gene Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Indicus|evm.model.CM009501.1.386 Q3T186 RPIA_BOVIN 100.000 0.856678 1.16288 RPIA - Ribose-5-phosphate isomerase - Bos taurus (Bovine) - RPIA gene intracellular membrane-bounded organelle, ribose-5-phosphate isomerase activity, D-ribose metabolic process, pentose-phosphate shunt, non-oxidative branch Indicus|evm.model.CM009501.1.387 Q9NZJ5 E2AK3_HUMAN 89.744 0.975806 1 EIF2AK3 - Eukaryotic translation initiation factor 2-alpha kinase 3 precursor - Homo sapiens (Human) - EIF2AK3 gene Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:33384352). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity). Indicus|evm.model.CM009501.1.388 A5PJD8 TEX37_BOVIN 98.333 0.98895 1.00556 TEX37 - Testis-expressed sequence 37 protein - Bos taurus (Bovine) - TEX37 gene cytoplasm Indicus|evm.model.CM009501.1.389 A8MTJ6 FOXI3_HUMAN 82.986 0.99308 0.688095 FOXI3 - Forkhead box protein I3 - Homo sapiens (Human) - FOXI3 gene Possible transcriptional factor. Indicus|evm.model.CM009501.1.390 P62979 RS27A_HUMAN 74.400 0.974576 0.75641 RPS27A - Ubiquitin-40S ribosomal protein S27a precursor - Homo sapiens (Human) - RPS27A gene Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Indicus|evm.model.CM009501.1.391 Q5RFE6 THNS2_PONAB 87.318 0.989691 1.00207 THNSL2 - Threonine synthase-like 2 - Pongo abelii (Sumatran orangutan) - THNSL2 gene Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity). Indicus|evm.model.CM009501.1.392 P80425 FABPL_BOVIN 100.000 0.984375 1.00787 FABP1 - Fatty acid-binding protein, liver - Bos taurus (Bovine) - FABP1 gene Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Indicus|evm.model.CM009501.1.393 Q8NB12 SMYD1_HUMAN 95.714 0.995927 1.00204 SMYD1 - Histone-lysine N-methyltransferase SMYD1 - Homo sapiens (Human) - SMYD1 gene Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. Indicus|evm.model.CM009501.1.394 Q17QQ9 KRCC1_BOVIN 99.611 0.992248 1.00389 KRCC1 - Lysine-rich coiled-coil protein 1 - Bos taurus (Bovine) - KRCC1 gene Indicus|evm.model.CM009501.1.395 Q92146 TBP_TRIGA 80.198 0.993421 1.00662 TBP - TATA-box-binding protein - Trimeresurus gramineus (Bamboo pit viper) - TBP gene General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Indicus|evm.model.CM009501.1.397 P79336 CD8B_FELCA 64.948 0.909953 1.00476 CD8B - T-cell surface glycoprotein CD8 beta chain precursor - Felis catus (Cat) - CD8B gene Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells. Indicus|evm.model.CM009501.1.398 P31783 CD8A_BOVIN 98.760 0.99177 1.00413 CD8A - T-cell surface glycoprotein CD8 alpha chain precursor - Bos taurus (Bovine) - CD8A gene Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. Indicus|evm.model.CM009501.1.399 Q80YQ8 RMD5A_MOUSE 100.000 0.994898 1.00256 Rmnd5a - E3 ubiquitin-protein ligase RMND5A - Mus musculus (Mouse) - Rmnd5a gene Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Indicus|evm.model.CM009501.1.400 O00237 RN103_HUMAN 97.372 0.997085 1.00146 RNF103 - E3 ubiquitin-protein ligase RNF103 - Homo sapiens (Human) - RNF103 gene Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway. Indicus|evm.model.CM009501.1.401 Q58CS7 CHMP3_BOVIN 100.000 0.991031 1.0045 CHMP3 - Charged multivesicular body protein 3 - Bos taurus (Bovine) - CHMP3 gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity). Indicus|evm.model.CM009501.1.402 Q9Y4C1 KDM3A_HUMAN 92.523 0.980712 1.02044 KDM3A - Lysine-specific demethylase 3A - Homo sapiens (Human) - KDM3A gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. Indicus|evm.model.CM009501.1.403 Q9H902 REEP1_HUMAN 89.706 0.669967 1.50746 REEP1 - Receptor expression-enhancing protein 1 - Homo sapiens (Human) - REEP1 gene Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (PubMed:20200447). May play a role in long-term axonal maintenance (PubMed:24478229). Indicus|evm.model.CM009501.1.404 Q3SZA9 RM35_BOVIN 100.000 0.989418 1.00532 MRPL35 - 39S ribosomal protein L35, mitochondrial precursor - Bos taurus (Bovine) - MRPL35 gene mitochondrial inner membrane, mitochondrion Indicus|evm.model.CM009501.1.405 Q16891 MIC60_HUMAN 89.021 0.98543 0.996042 IMMT - MICOS complex subunit MIC60 precursor - Homo sapiens (Human) - IMMT gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180). Indicus|evm.model.CM009501.1.406 Q2KI62 PTCD3_BOVIN 99.855 0.997097 1.00145 PTCD3 - Pentatricopeptide repeat domain-containing protein 3, mitochondrial precursor - Bos taurus (Bovine) - PTCD3 gene Mitochondrial RNA-binding protein that has a role in mitochondrial translation. Indicus|evm.model.CM009501.1.407 O95602 RPA1_HUMAN 90.180 0.998836 0.998837 POLR1A - DNA-directed RNA polymerase I subunit RPA1 - Homo sapiens (Human) - POLR1A gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Indicus|evm.model.CM009501.1.408 Q70D51 SIAT9_BOVIN 99.762 0.995249 1.00238 ST3GAL5 - Lactosylceramide alpha-2,3-sialyltransferase - Bos taurus (Bovine) - ST3GAL5 gene Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1 Indicus|evm.model.CM009501.1.409 Q96SQ7 ATOH8_HUMAN 89.130 0.993711 0.990654 ATOH8 - Protein atonal homolog 8 - Homo sapiens (Human) - ATOH8 gene Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (PubMed:24236640). Regulates endothelial cell proliferation, migration and tube-like structures formation (PubMed:24463812). Modulates endothelial cell differentiation through NOS3 (PubMed:24463812). May be implicated in specification and differentiation of neuronal cell lineages in the brain (By similarity). May participate in kidney development and may be involved in podocyte differentiation (By similarity). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (By similarity). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (By similarity). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (PubMed:24236640). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (By similarity). Indicus|evm.model.CM009501.1.410 Q29075 NKL_PIG 58.400 0.843537 1.13953 NKL - Antimicrobial peptide NK-lysin precursor - Sus scrofa (Pig) - NKL gene May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. Indicus|evm.model.CM009501.1.411 Q29075 NKL_PIG 52.174 0.357143 0.976744 NKL - Antimicrobial peptide NK-lysin precursor - Sus scrofa (Pig) - NKL gene May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. Indicus|evm.model.CM009501.1.412 Q29075 NKL_PIG 55.039 0.876712 1.13178 NKL - Antimicrobial peptide NK-lysin precursor - Sus scrofa (Pig) - NKL gene May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. Indicus|evm.model.CM009501.1.413 P15781 PSPB_BOVIN 99.732 0.994652 1.00268 SFTPB - Pulmonary surfactant-associated protein B precursor - Bos taurus (Bovine) - SFTPB gene Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. Indicus|evm.model.CM009501.1.414 Q53GS9 SNUT2_HUMAN 97.876 0.996466 1.00177 USP39 - U4/U6.U5 tri-snRNP-associated protein 2 - Homo sapiens (Human) - USP39 gene Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity (PubMed:18728397). Indicus|evm.model.CM009501.1.415 A4IFR8 CB068_BOVIN 100.000 0.988024 1.00602 UPF0561 protein C2orf68 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009501.1.416 Q86TG1 T150A_HUMAN 92.620 0.992647 1.00369 TMEM150A - Transmembrane protein 150A - Homo sapiens (Human) - TMEM150A gene Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity). Indicus|evm.model.CM009501.1.417 Q3T0W3 RN181_BOVIN 100.000 0.987013 1.00654 RNF181 - E3 ubiquitin-protein ligase RNF181 - Bos taurus (Bovine) - RNF181 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Indicus|evm.model.CM009501.1.418 Q2KHY2 VAMP5_BOVIN 99.138 0.982906 1.00862 VAMP5 - Vesicle-associated membrane protein 5 - Bos taurus (Bovine) - VAMP5 gene May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking. Indicus|evm.model.CM009501.1.419 Q3T0Y8 VAMP8_BOVIN 100.000 0.649007 1.51 VAMP8 - Vesicle-associated membrane protein 8 - Bos taurus (Bovine) - VAMP8 gene SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (By similarity). Indicus|evm.model.CM009501.1.420 Q07175 VKGC_BOVIN 99.310 0.997245 0.957784 GGCX - Vitamin K-dependent gamma-carboxylase - Bos taurus (Bovine) - GGCX gene Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Indicus|evm.model.CM009501.1.421 Q5R5H1 METK2_PONAB 99.241 0.994949 1.00253 MAT2A - S-adenosylmethionine synthase isoform type-2 - Pongo abelii (Sumatran orangutan) - MAT2A gene Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Indicus|evm.model.CM009501.1.422 Q7Z4S9 SH2D6_HUMAN 79.562 0.251852 3.08571 SH2D6 - SH2 domain-containing protein 6 - Homo sapiens (Human) - SH2D6 gene cytoplasm, intracellular signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway Indicus|evm.model.CM009501.1.423 Q865V6 CAPG_BOVIN 100.000 0.994286 1.00287 CAPG - Macrophage-capping protein - Bos taurus (Bovine) - CAPG gene Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA (By similarity). Indicus|evm.model.CM009501.1.424 Q58DT5 ELMD3_BOVIN 88.480 0.995098 1.07087 ELMOD3 - ELMO domain-containing protein 3 - Bos taurus (Bovine) - ELMOD3 gene Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity. Indicus|evm.model.CM009501.1.425 Q6NUM9 RETST_HUMAN 80.912 0.968852 1 RETSAT - All-trans-retinol 13,14-reductase precursor - Homo sapiens (Human) - RETSAT gene Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. Indicus|evm.model.CM009501.1.426 P19814 TGON3_RAT 67.568 0.472131 0.854342 Ttgn1 - Trans-Golgi network integral membrane protein TGN38 precursor - Rattus norvegicus (Rat) - Ttgn1 gene endosome, Golgi apparatus, integral component of membrane, trans-Golgi network, trans-Golgi network transport vesicle, Golgi to endosome transport Indicus|evm.model.CM009501.1.427 Q9HCS4 TF7L1_HUMAN 96.834 0.990758 0.920068 TCF7L1 - Transcription factor 7-like 1 - Homo sapiens (Human) - TCF7L1 gene Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. Indicus|evm.model.CM009501.1.428 Q1LZE1 KCMF1_BOVIN 89.501 0.99422 0.908136 KCMF1 - E3 ubiquitin-protein ligase KCMF1 - Bos taurus (Bovine) - KCMF1 gene Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. Indicus|evm.model.CM009501.1.429 P21752 TYB10_BOVIN 97.059 0.294643 2.66667 TMSB10 - Thymosin beta-10 - Bos taurus (Bovine) - TMSB10 gene Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). Indicus|evm.model.CM009501.1.430 F6PTN1 TIKI1_XENTR 58.824 0.441441 0.218504 trabd2a - Metalloprotease TIKI1 precursor - Xenopus tropicalis (Western clawed frog) - trabd2a gene Metalloprotease that acts as a negative regulator of the Wnt signaling pathway: expressed in the Spemann-Mangold organizer and is required for anterior-neural patterning in head formation in embryos. Acts by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave wnt8. Indicus|evm.model.CM009501.1.431 Q9C0G6 DYH6_HUMAN 90.424 0.941752 0.957912 DNAH6 - Dynein axonemal heavy chain 6 - Homo sapiens (Human) - DNAH6 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Indicus|evm.model.CM009501.1.432 Q58DR8 SUCA_BOVIN 99.700 0.994012 0.965318 SUCLG1 - Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - SUCLG1 gene Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Indicus|evm.model.CM009501.1.433 Q3MHN8 TRM5_BOVIN 85.714 0.932886 0.299799 TRMT5 - tRNA (guanine(37)-N1)-methyltransferase - Bos taurus (Bovine) - TRMT5 gene Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Indicus|evm.model.CM009501.1.434 Q5R416 CTNA2_PONAB 95.205 0.462639 0.695028 CTNNA2 - Catenin alpha-2 - Pongo abelii (Sumatran orangutan) - CTNNA2 gene May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation. Indicus|evm.model.CM009501.1.435 A4IGI7 CTNA2_XENTR 96.203 0.503226 0.160455 ctnna2 - Catenin alpha-2 - Xenopus tropicalis (Western clawed frog) - ctnna2 gene May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Indicus|evm.model.CM009501.1.436 P15927 RFA2_HUMAN 83.704 0.980545 0.951852 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Indicus|evm.model.CM009501.1.437 A1A4H9 LRRT1_BOVIN 100.000 0.996169 1.00192 LRRTM1 - Leucine-rich repeat transmembrane neuronal protein 1 precursor - Bos taurus (Bovine) - LRRTM1 gene Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level. Indicus|evm.model.CM009501.1.438 Q5R416 CTNA2_PONAB 98.154 0.933718 0.383425 CTNNA2 - Catenin alpha-2 - Pongo abelii (Sumatran orangutan) - CTNNA2 gene May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation. Indicus|evm.model.CM009501.1.440 P23132 LITH_BOVIN 70.520 0.976879 0.988571 PTP - Lithostathine precursor - Bos taurus (Bovine) - PTP gene Might act as an inhibitor of spontaneous calcium carbonate precipitation. Indicus|evm.model.CM009501.1.441 P23132 LITH_BOVIN 98.857 0.988636 1.00571 PTP - Lithostathine precursor - Bos taurus (Bovine) - PTP gene Might act as an inhibitor of spontaneous calcium carbonate precipitation. Indicus|evm.model.CM009501.1.442 P63221 RS21_PIG 86.747 0.88172 1.12048 RPS21 - 40S ribosomal protein S21 - Sus scrofa (Pig) - RPS21 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, ribosome binding, structural constituent of ribosome, cytoplasmic translation, endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009501.1.445 Q86VH4 LRRT4_HUMAN 96.318 0.996132 0.876271 LRRTM4 - Leucine-rich repeat transmembrane neuronal protein 4 precursor - Homo sapiens (Human) - LRRTM4 gene May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). Indicus|evm.model.CM009501.1.447 O97755 VATD_RABIT 85.294 0.957143 0.283401 ATP6V1D - V-type proton ATPase subunit D - Oryctolagus cuniculus (Rabbit) - ATP6V1D gene Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). Indicus|evm.model.CM009501.1.448 Q96KR7 PHAR3_HUMAN 88.439 0.791667 0.386404 PHACTR3 - Phosphatase and actin regulator 3 - Homo sapiens (Human) - PHACTR3 gene nucleoplasm, actin binding, actin cytoskeleton organization Indicus|evm.model.CM009501.1.449 B4F7C5 LRRT4_RAT 88.732 0.933333 0.127119 Lrrtm4 - Leucine-rich repeat transmembrane neuronal protein 4 precursor - Rattus norvegicus (Rat) - Lrrtm4 gene May play a role in the development and maintenance of the nervous system (By similarity). Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation. Indicus|evm.model.CM009501.1.450 A8MZ97 CB074_HUMAN 61.856 0.989247 0.958763 C2orf74 - Uncharacterized protein C2orf74 - Homo sapiens (Human) - C2orf74 gene Indicus|evm.model.CM009501.1.451 A6QQC0 AHSA2_BOVIN 99.598 0.740299 1.28846 AHSA2 - Activator of 90 kDa heat shock protein ATPase homolog 2 - Bos taurus (Bovine) - AHSA2 gene Co-chaperone that stimulates HSP90 ATPase activity. Indicus|evm.model.CM009501.1.452 Q70CQ2 UBP34_HUMAN 98.506 0.999436 1.00056 USP34 - Ubiquitin carboxyl-terminal hydrolase 34 - Homo sapiens (Human) - USP34 gene Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Indicus|evm.model.CM009501.1.453 Q6P5F9 XPO1_MOUSE 99.160 0.998134 1.00093 Xpo1 - Exportin-1 - Mus musculus (Mouse) - Xpo1 gene Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity). Indicus|evm.model.CM009501.1.454 Q5RFQ0 FCF1_PONAB 96.364 0.987952 0.838384 FCF1 - rRNA-processing protein FCF1 homolog - Pongo abelii (Sumatran orangutan) - FCF1 gene Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Indicus|evm.model.CM009501.1.456 Q3B820 F161A_HUMAN 76.190 0.975976 1.00909 FAM161A - Protein FAM161A - Homo sapiens (Human) - FAM161A gene Involved in ciliogenesis. Indicus|evm.model.CM009501.1.457 Q8N3K9 CMYA5_HUMAN 84.496 0.810127 0.0388302 CMYA5 - Cardiomyopathy-associated protein 5 - Homo sapiens (Human) - CMYA5 gene May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). Indicus|evm.model.CM009501.1.458 Q2T9X2 TCPD_BOVIN 99.083 0.996337 1.00738 CCT4 - T-complex protein 1 subunit delta - Bos taurus (Bovine) - CCT4 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.CM009501.1.459 Q2M2T5 COMD1_BOVIN 99.468 0.989418 1.00532 COMMD1 - COMM domain-containing protein 1 - Bos taurus (Bovine) - COMMD1 gene Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1. Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner. Indicus|evm.model.CM009501.1.461 Q9NY97 B3GN2_HUMAN 88.665 0.994975 1.00252 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Homo sapiens (Human) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. Indicus|evm.model.CM009501.1.462 A4FUY9 TMM17_BOVIN 100.000 0.98995 1.00505 TMEM17 - Transmembrane protein 17 - Bos taurus (Bovine) - TMEM17 gene Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). Indicus|evm.model.CM009501.1.463 Q8NDI1 EHBP1_HUMAN 89.805 0.998172 0.888708 EHBP1 - EH domain-binding protein 1 - Homo sapiens (Human) - EHBP1 gene May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). Indicus|evm.model.CM009501.1.465 P32242 OTX1_HUMAN 97.465 0.808219 1.23729 OTX1 - Homeobox protein OTX1 - Homo sapiens (Human) - OTX1 gene Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Indicus|evm.model.CM009501.1.466 Q2M2T7 RT24_BOVIN 95.808 0.988095 1.00599 MRPS24 - 28S ribosomal protein S24, mitochondrial precursor - Bos taurus (Bovine) - MRPS24 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009501.1.467 O95876 FRITZ_HUMAN 82.671 0.64486 0.573727 WDPCP - WD repeat-containing and planar cell polarity effector protein fritz homolog - Homo sapiens (Human) - WDPCP gene Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). Indicus|evm.model.CM009501.1.468 Q3T145 MDHC_BOVIN 100.000 0.99403 1.00299 MDH1 - Malate dehydrogenase, cytoplasmic - Bos taurus (Bovine) - MDH1 gene Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Indicus|evm.model.CM009501.1.470 Q07130 UGPA_BOVIN 100.000 0.995984 0.980315 UGP2 - UTP--glucose-1-phosphate uridylyltransferase - Bos taurus (Bovine) - UGP2 gene UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. Indicus|evm.model.CM009501.1.471 Q9P1Q0 VPS54_HUMAN 95.906 0.997955 1.00102 VPS54 - Vacuolar protein sorting-associated protein 54 - Homo sapiens (Human) - VPS54 gene Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061). Indicus|evm.model.CM009501.1.472 Q96FA3 PELI1_HUMAN 99.522 0.995227 1.00239 PELI1 - E3 ubiquitin-protein ligase pellino homolog 1 - Homo sapiens (Human) - PELI1 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). Indicus|evm.model.CM009501.1.473 Q9ULL8 SHRM4_HUMAN 95.455 0.878788 0.0663094 SHROOM4 - Protein Shroom4 - Homo sapiens (Human) - SHROOM4 gene Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). Indicus|evm.model.CM009501.1.474 Q8VED9 LEGL_MOUSE 100.000 0.988439 1.00581 Lgalsl - Galectin-related protein - Mus musculus (Mouse) - Lgalsl gene Does not bind lactose, and may not bind carbohydrates. Indicus|evm.model.CM009501.1.475 Q6ULP2 AFTIN_HUMAN 87.007 0.997856 0.996795 AFTPH - Aftiphilin - Homo sapiens (Human) - AFTPH gene Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). Indicus|evm.model.CM009501.1.476 Q9JJG5 SRTD2_MOUSE 100.000 0.0933333 0.728155 Sertad2 - SERTA domain-containing protein 2 - Mus musculus (Mouse) - Sertad2 gene Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. Indicus|evm.model.CM009501.1.477 P20065 TYB4_MOUSE 100.000 0.737705 1.22 Tmsb4x - Thymosin beta-4 - Mus musculus (Mouse) - Tmsb4x gene Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Indicus|evm.model.CM009501.1.478 A2VDL4 SATT_BOVIN 100.000 0.996234 1.00189 SLC1A4 - Neutral amino acid transporter A - Bos taurus (Bovine) - SLC1A4 gene Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Indicus|evm.model.CM009501.1.479 Q5RCQ2 CEP68_PONAB 70.580 0.985526 1.01198 CEP68 - Centrosomal protein of 68 kDa - Pongo abelii (Sumatran orangutan) - CEP68 gene Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Indicus|evm.model.CM009501.1.480 Q6NYB7 RAB1A_RAT 100.000 0.990291 1.00488 Rab1A - Ras-related protein Rab-1A - Rattus norvegicus (Rat) - Rab1A gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21303926). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21303926). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926). Regulates the level of CASR present at the cell membrane (By similarity). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (By similarity). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity). Indicus|evm.model.CM009501.1.481 P61161 ARP2_MOUSE 98.223 0.994845 0.984772 Actr2 - Actin-related protein 2 - Mus musculus (Mouse) - Actr2 gene ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Indicus|evm.model.CM009501.1.482 Q7Z698 SPRE2_HUMAN 97.608 0.995215 1 SPRED2 - Sprouty-related, EVH1 domain-containing protein 2 - Homo sapiens (Human) - SPRED2 gene Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Indicus|evm.model.CM009501.1.487 Q6UXQ4 CB066_HUMAN 77.381 0.83 0.854701 C2orf66 - Uncharacterized protein C2orf66 precursor - Homo sapiens (Human) - C2orf66 gene Indicus|evm.model.CM009501.1.488 Q08DI1 ETAA1_BOVIN 99.666 0.997778 1.00111 ETAA1 - Ewing's tumor-associated antigen 1 homolog - Bos taurus (Bovine) - ETAA1 gene Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. Indicus|evm.model.CM009501.1.490 Q32PE4 C1D_BOVIN 100.000 0.740741 1.34043 C1D - Nuclear nucleic acid-binding protein C1D - Bos taurus (Bovine) - C1D gene Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). Indicus|evm.model.CM009501.1.491 Q29RZ9 WDR92_BOVIN 99.720 0.994413 1.0028 DNAAF10 - Dynein axonemal assembly factor 10 - Bos taurus (Bovine) - DNAAF10 gene Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm. Indicus|evm.model.CM009501.1.492 Q7YRD0 PNO1_BOVIN 100.000 0.992095 1.00397 PNO1 - RNA-binding protein PNO1 - Bos taurus (Bovine) - PNO1 gene Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. Indicus|evm.model.CM009501.1.493 P63100 CANB1_RAT 100.000 0.988304 1.00588 Ppp3r1 - Calcineurin subunit B type 1 - Rattus norvegicus (Rat) - Ppp3r1 gene Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Indicus|evm.model.CM009501.1.494 Q17QM9 CNRP1_BOVIN 99.390 0.987879 1.0061 CNRIP1 - CB1 cannabinoid receptor-interacting protein 1 - Bos taurus (Bovine) - CNRIP1 gene Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Indicus|evm.model.CM009501.1.495 P08567 PLEK_HUMAN 94.571 0.994302 1.00286 PLEK - Pleckstrin - Homo sapiens (Human) - PLEK gene Major protein kinase C substrate of platelets. Indicus|evm.model.CM009501.1.496 Q5FWF7 FBX48_HUMAN 86.452 0.987179 1.00645 FBXO48 - F-box only protein 48 - Homo sapiens (Human) - FBXO48 gene SCF ubiquitin ligase complex, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Indicus|evm.model.CM009501.1.497 Q8IW19 APLF_HUMAN 75.124 0.448198 0.868885 APLF - Aprataxin and PNK-like factor - Homo sapiens (Human) - APLF gene Nuclease involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150). Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721). Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17353262, PubMed:17396150). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). Indicus|evm.model.CM009501.1.498 Q8SPN2 PKR1_BOVIN 99.746 0.915888 1.08906 PROKR1 - Prokineticin receptor 1 - Bos taurus (Bovine) - PROKR1 gene Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity). Indicus|evm.model.CM009501.1.500 P42331 RHG25_HUMAN 88.978 0.950845 1.0093 ARHGAP25 - Rho GTPase-activating protein 25 - Homo sapiens (Human) - ARHGAP25 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009501.1.501 O95393 BMP10_HUMAN 89.858 0.995294 1.00236 BMP10 - Bone morphogenetic protein 10 precursor - Homo sapiens (Human) - BMP10 gene Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. Indicus|evm.model.CM009501.1.502 D2XPP7 GKN3_PIG 85.380 0.982558 0.950276 GKN3 - Gastrokine-3 precursor - Sus scrofa (Pig) - GKN3 gene May inhibit gastric epithelial cell proliferation. Indicus|evm.model.CM009501.1.503 Q86XP6 GKN2_HUMAN 75.000 0.989189 1.00543 GKN2 - Gastrokine-2 precursor - Homo sapiens (Human) - GKN2 gene extracellular space, regulation of cell population proliferation Indicus|evm.model.CM009501.1.504 Q8HYA9 GKN1_PIG 76.757 0.989247 0.939394 GKN1 - Gastrokine-1 precursor - Sus scrofa (Pig) - GKN1 gene Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. Indicus|evm.model.CM009501.1.505 Q9H6X2 ANTR1_HUMAN 97.518 0.99646 1.00177 ANTXR1 - Anthrax toxin receptor 1 precursor - Homo sapiens (Human) - ANTXR1 gene Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. Indicus|evm.model.CM009501.1.506 P82808 GFPT1_RAT 91.579 0.988848 0.790015 Gfpt1 - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 - Rattus norvegicus (Rat) - Gfpt1 gene Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1. Indicus|evm.model.CM009501.1.507 Q9UMS0 NFU1_HUMAN 92.490 0.984314 1.00394 NFU1 - NFU1 iron-sulfur cluster scaffold homolog, mitochondrial precursor - Homo sapiens (Human) - NFU1 gene Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins. Indicus|evm.model.CM009501.1.508 F1MH24 AAK1_BOVIN 99.892 0.712635 1.35632 AAK1 - AP2-associated protein kinase 1 - Bos taurus (Bovine) - AAK1 gene Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. Indicus|evm.model.CM009501.1.509 P13214 ANXA4_BOVIN 100.000 0.99375 1.00313 ANXA4 - Annexin A4 - Bos taurus (Bovine) - ANXA4 gene May play a role in alveolar type II cells through interaction with the surfactant protein SFTPA1 (SP-A). Indicus|evm.model.CM009501.1.510 Q96IK5 GMCL1_HUMAN 93.580 0.973435 1.0233 GMCL1 - Germ cell-less protein-like 1 - Homo sapiens (Human) - GMCL1 gene Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Indicus|evm.model.CM009501.1.511 Q6GLZ8 SNR27_XENLA 85.135 0.394595 1.17089 snrnp27 - U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein - Xenopus laevis (African clawed frog) - snrnp27 gene May play a role in mRNA splicing. Indicus|evm.model.CM009501.1.512 Q05195 MAD1_HUMAN 95.946 0.991031 1.00905 MXD1 - Max dimerization protein 1 - Homo sapiens (Human) - MXD1 gene Component of a transcriptional repressor complex together with MAX (PubMed:8425218). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218). Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218). Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246). Indicus|evm.model.CM009501.1.513 Q53RT3 APRV1_HUMAN 86.434 0.988281 0.746356 ASPRV1 - Retroviral-like aspartic protease 1 precursor - Homo sapiens (Human) - ASPRV1 gene Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization. Indicus|evm.model.CM009501.1.514 O19048 PCBP1_RABIT 100.000 0.994398 1.00281 PCBP1 - Poly(rC)-binding protein 1 - Oryctolagus cuniculus (Rabbit) - PCBP1 gene Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Indicus|evm.model.CM009501.1.515 Q3SYX3 CB042_BOVIN 99.826 0.996522 1.00174 Uncharacterized protein C2orf42 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009501.1.516 P31483 TIA1_HUMAN 98.187 0.994832 1.00259 TIA1 - Nucleolysin TIA-1 isoform p40 - Homo sapiens (Human) - TIA1 gene Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. Indicus|evm.model.CM009501.1.517 Q95KC9 PCYOX_MACFA 79.418 0.943026 1.00792 PCYOX1 - Prenylcysteine oxidase precursor - Macaca fascicularis (Crab-eating macaque) - PCYOX1 gene Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (By similarity). Indicus|evm.model.CM009501.1.518 P62309 RUXG_MOUSE 100.000 0.974026 1.01316 Snrpg - Small nuclear ribonucleoprotein G - Mus musculus (Mouse) - Snrpg gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. Indicus|evm.model.CM009501.1.519 Q9NZN3 EHD3_HUMAN 97.009 0.996269 1.00187 EHD3 - EH domain-containing protein 3 - Homo sapiens (Human) - EHD3 gene ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250). Indicus|evm.model.CM009501.1.520 A8MX76 CAN14_HUMAN 79.425 0.932203 1.03509 CAPN14 - Calpain-14 - Homo sapiens (Human) - CAPN14 gene Calcium-regulated non-lysosomal thiol-protease. Indicus|evm.model.CM009501.1.521 Q96FL9 GLT14_HUMAN 90.217 0.996383 1.00181 GALNT14 - Polypeptide N-acetylgalactosaminyltransferase 14 - Homo sapiens (Human) - GALNT14 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney. Indicus|evm.model.CM009501.1.522 Q5BK10 CAN13_RAT 66.119 0.99701 1.0015 Capn13 - Calpain-13 - Rattus norvegicus (Rat) - Capn13 gene Probable non-lysosomal thiol-protease. Indicus|evm.model.CM009501.1.523 Q6UWP7 LCLT1_HUMAN 91.223 0.994695 0.910628 LCLAT1 - Lysocardiolipin acyltransferase 1 - Homo sapiens (Human) - LCLAT1 gene Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16620771). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (PubMed:19075029). Required for establishment of the hematopoietic and endothelial lineages (By similarity). Indicus|evm.model.CM009501.1.524 A5PJU8 LBH_BOVIN 100.000 0.981132 1.00952 LBH - Protein LBH - Bos taurus (Bovine) - LBH gene Transcriptional activator. Indicus|evm.model.CM009501.1.525 Q5RDU7 YPEL5_PONAB 100.000 0.983607 1.00826 YPEL5 - Protein yippee-like 5 - Pongo abelii (Sumatran orangutan) - YPEL5 gene Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for normal cell proliferation (By similarity). Indicus|evm.model.CM009501.1.526 Q9UM73 ALK_HUMAN 83.333 0.974249 0.143827 ALK - ALK tyrosine kinase receptor precursor - Homo sapiens (Human) - ALK gene Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Indicus|evm.model.CM009501.1.527 P97793 ALK_MOUSE 92.754 0.839506 0.0499692 Alk - ALK tyrosine kinase receptor precursor - Mus musculus (Mouse) - Alk gene Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (PubMed:32442405). Indicus|evm.model.CM009501.1.528 Q9UM73 ALK_HUMAN 97.606 0.710421 0.616049 ALK - ALK tyrosine kinase receptor precursor - Homo sapiens (Human) - ALK gene Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Indicus|evm.model.CM009501.1.529 Q8N3C7 CLIP4_HUMAN 91.348 0.997163 1 CLIP4 - CAP-Gly domain-containing linker protein 4 - Homo sapiens (Human) - CLIP4 gene cytoplasm, intracellular membrane-bounded organelle, microtubule plus-end, nucleus, microtubule plus-end binding, cytoplasmic microtubule organization Indicus|evm.model.CM009501.1.530 A6NGG8 PCARE_HUMAN 64.422 0.994648 1.01553 PCARE - Photoreceptor cilium actin regulator - Homo sapiens (Human) - PCARE gene Plays an essential role for normal photoreceptor cell maintenance and vision. Indicus|evm.model.CM009501.1.531 Q6ZUX3 TGRM2_HUMAN 79.355 0.996976 0.973503 TOGARAM2 - TOG array regulator of axonemal microtubules protein 2 - Homo sapiens (Human) - TOGARAM2 gene cilium, cytoplasmic microtubule, microtubule organizing center, mitotic spindle, spindle microtubule, microtubule binding, microtubule cytoskeleton organization, mitotic spindle assembly Indicus|evm.model.CM009501.1.532 Q15061 WDR43_HUMAN 90.176 0.997067 1.00739 WDR43 - WD repeat-containing protein 43 - Homo sapiens (Human) - WDR43 gene Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). Indicus|evm.model.CM009501.1.533 Q9BVS5 TR61B_HUMAN 73.237 0.995781 0.993711 TRMT61B - tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial precursor - Homo sapiens (Human) - TRMT61B gene Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537). Indicus|evm.model.CM009501.1.534 Q6GQL2 PP1B_XENLA 100.000 0.527434 1.72783 ppp1cb - Serine/threonine-protein phosphatase PP1-beta catalytic subunit - Xenopus laevis (African clawed frog) - ppp1cb gene Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity (By similarity). Indicus|evm.model.CM009501.1.535 Q6P1J6 PLB1_HUMAN 72.432 0.958904 0.901235 PLB1 - Phospholipase B1, membrane-associated precursor - Homo sapiens (Human) - PLB1 gene Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity). Indicus|evm.model.CM009501.1.536 P15408 FOSL2_HUMAN 97.554 0.993902 1.00613 FOSL2 - Fos-related antigen 2 - Homo sapiens (Human) - FOSL2 gene Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. Indicus|evm.model.CM009501.1.537 A6QQW8 BABA2_BOVIN 99.739 0.994792 1.00261 BABAM2 - BRISC and BRCA1-A complex member 2 - Bos taurus (Bovine) - BABAM2 gene Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect. Indicus|evm.model.CM009501.1.538 Q9H477 RBSK_HUMAN 88.923 0.993865 1.01242 RBKS - Ribokinase - Homo sapiens (Human) - RBKS gene Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. Indicus|evm.model.CM009501.1.539 Q9BWU0 NADAP_HUMAN 84.501 0.997301 0.930905 SLC4A1AP - Kanadaptin - Homo sapiens (Human) - SLC4A1AP gene intracellular membrane-bounded organelle, nucleoplasm, plasma membrane, mRNA binding Indicus|evm.model.CM009501.1.540 O94864 ST65G_HUMAN 96.845 0.995157 0.997585 SUPT7L - STAGA complex 65 subunit gamma - Homo sapiens (Human) - SUPT7L gene nucleoplasm, nucleus, STAGA complex, transcription coactivator activity, histone H3 acetylation, maintenance of protein location in nucleus Indicus|evm.model.CM009501.1.541 A4FUD1 GPN1_BOVIN 100.000 0.994652 1.00268 GPN1 - GPN-loop GTPase 1 - Bos taurus (Bovine) - GPN1 gene Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA. Indicus|evm.model.CM009501.1.543 A4FV61 ZN512_BOVIN 100.000 0.996479 1.00176 ZNF512 - Zinc finger protein 512 - Bos taurus (Bovine) - ZNF512 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009501.1.544 Q68DN1 CB016_HUMAN 59.290 0.288552 2.99395 C2orf16 - Uncharacterized protein C2orf16 - Homo sapiens (Human) - C2orf16 gene extracellular exosome, nucleus Indicus|evm.model.CM009501.1.545 Q14397 GCKR_HUMAN 60.546 0.991477 0.5632 GCKR - Glucokinase regulatory protein - Homo sapiens (Human) - GCKR gene Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961). Indicus|evm.model.CM009501.1.546 A6QPL2 FNDC4_BOVIN 97.436 0.96875 0.695652 FNDC4 - Fibronectin type III domain-containing protein 4 precursor - Bos taurus (Bovine) - FNDC4 gene Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. Indicus|evm.model.CM009501.1.547 Q9JKU3 IF172_RAT 97.313 0.998857 1.00057 Ift172 - Intraflagellar transport protein 172 homolog - Rattus norvegicus (Rat) - Ift172 gene Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Indicus|evm.model.CM009501.1.548 Q3SZ72 KCP3_BOVIN 100.000 0.173709 3.55 KRTCAP3 - Keratinocyte-associated protein 3 - Bos taurus (Bovine) - KRTCAP3 gene Indicus|evm.model.CM009501.1.549 P79126 PPM1G_BOVIN 100.000 0.996324 1.00184 PPM1G - Protein phosphatase 1G - Bos taurus (Bovine) - PPM1G gene nucleoplasm, protein serine/threonine phosphatase activity, protein dephosphorylation Indicus|evm.model.CM009501.1.550 Q8N8E2 ZN513_HUMAN 96.494 0.994475 1.0037 ZNF513 - Zinc finger protein 513 - Homo sapiens (Human) - ZNF513 gene Transcriptional regulator that plays a role in retinal development and maintenance. Indicus|evm.model.CM009501.1.551 Q5EA77 SNX17_BOVIN 100.000 0.995754 1.00213 SNX17 - Sorting nexin-17 - Bos taurus (Bovine) - SNX17 gene Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). Indicus|evm.model.CM009501.1.552 Q3T058 EI2BD_BOVIN 99.809 0.99619 1.00191 EIF2B4 - Translation initiation factor eIF-2B subunit delta - Bos taurus (Bovine) - EIF2B4 gene Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Indicus|evm.model.CM009501.1.553 Q5RDC3 TF3C2_PONAB 89.791 0.997802 0.998902 GTF3C2 - General transcription factor 3C polypeptide 2 - Pongo abelii (Sumatran orangutan) - GTF3C2 gene Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 (By similarity). Indicus|evm.model.CM009501.1.554 Q2KIN6 MPV17_BOVIN 99.432 0.988701 1.00568 MPV17 - Protein Mpv17 - Bos taurus (Bovine) - MPV17 gene Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (By similarity). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity). Indicus|evm.model.CM009501.1.555 P55089 UCN1_HUMAN 83.721 0.984615 1.04839 UCN - Urocortin precursor - Homo sapiens (Human) - UCN gene Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity). Indicus|evm.model.CM009501.1.556 Q58D15 TRI54_BOVIN 100.000 0.99455 1.00273 TRIM54 - Tripartite motif-containing protein 54 - Bos taurus (Bovine) - TRIM54 gene May bind and stabilize microtubules during myotubes formation. Indicus|evm.model.CM009501.1.557 Q8N7S2 DNJ5G_HUMAN 68.783 0.982857 0.925926 DNAJC5G - DnaJ homolog subfamily C member 5G - Homo sapiens (Human) - DNAJC5G gene Indicus|evm.model.CM009501.1.558 Q08E25 ZNT3_BOVIN 100.000 0.994859 1.00258 SLC30A3 - Zinc transporter 3 - Bos taurus (Bovine) - SLC30A3 gene Involved in accumulation of zinc in synaptic vesicles. Indicus|evm.model.CM009501.1.559 P27708 PYR1_HUMAN 95.909 0.909354 1.08584 CAD - CAD protein - Homo sapiens (Human) - CAD gene This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). Indicus|evm.model.CM009501.1.560 Q9XT77 SC5A6_RABIT 88.245 0.99687 1.00472 SLC5A6 - Sodium-dependent multivitamin transporter - Oryctolagus cuniculus (Rabbit) - SLC5A6 gene Sodium-dependent multivitamin transporter that transports pantothenate, biotin and lipoate (By similarity). Required for biotin and pantothenate uptake in the instestine (By similarity). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). May play a role in the transport of biotin and pantothenate into the brain across the blood-brain barrier (By similarity). May also be involved in the sodium-dependent transport of iodide ions (By similarity). Indicus|evm.model.CM009501.1.561 Q2T9Q7 TCF23_BOVIN 99.507 0.990196 0.953271 TCF23 - Transcription factor 23 - Bos taurus (Bovine) - TCF23 gene Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity). Indicus|evm.model.CM009501.1.562 Q53SZ7 PRR30_HUMAN 65.122 0.989975 0.968447 PRR30 - Proline-rich protein 30 - Homo sapiens (Human) - PRR30 gene Indicus|evm.model.CM009501.1.563 Q9HCU5 PREB_HUMAN 92.584 0.995227 1.0048 PREB - Prolactin regulatory element-binding protein - Homo sapiens (Human) - PREB gene Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. Indicus|evm.model.CM009501.1.564 Q3T0A0 ABHD1_BOVIN 100.000 0.995062 1.00248 ABHD1 - Protein ABHD1 - Bos taurus (Bovine) - ABHD1 gene acetylesterase activity, acylglycerol lipase activity, short-chain carboxylesterase activity, cellular lipid metabolic process, medium-chain fatty acid biosynthetic process, medium-chain fatty acid catabolic process Indicus|evm.model.CM009501.1.565 Q8R1U2 CGRE1_MOUSE 60.985 0.927757 0.935943 Cgref1 - Cell growth regulator with EF hand domain protein 1 precursor - Mus musculus (Mouse) - Cgref1 gene Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines (By similarity). Indicus|evm.model.CM009501.1.566 Q02974 KHK_RAT 78.426 0.994186 1.15436 Khk - Ketohexokinase - Rattus norvegicus (Rat) - Khk gene Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. Indicus|evm.model.CM009501.1.567 Q9Y6C2 EMIL1_HUMAN 89.980 0.998031 1 EMILIN1 - EMILIN-1 precursor - Homo sapiens (Human) - EMILIN1 gene May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. Indicus|evm.model.CM009501.1.568 B0BLS0 OST4_RAT 100.000 0.5 1.94595 Ost4 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 - Rattus norvegicus (Rat) - Ost4 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes. Indicus|evm.model.CM009501.1.569 Q58CX9 CBPC5_BOVIN 99.887 0.997743 1.00113 AGBL5 - Cytosolic carboxypeptidase-like protein 5 - Bos taurus (Bovine) - AGBL5 gene Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Indicus|evm.model.CM009501.1.570 A4FV45 TM214_BOVIN 99.709 0.997093 1.00146 TMEM214 - Transmembrane protein 214 - Bos taurus (Bovine) - TMEM214 gene Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity). Indicus|evm.model.CM009501.1.571 Q9UPY8 MARE3_HUMAN 99.644 0.968858 1.02847 MAPRE3 - Microtubule-associated protein RP/EB family member 3 - Homo sapiens (Human) - MAPRE3 gene Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity). Indicus|evm.model.CM009501.1.572 Q9BPU6 DPYL5_HUMAN 98.936 0.99646 1.00177 DPYSL5 - Dihydropyrimidinase-related protein 5 - Homo sapiens (Human) - DPYSL5 gene May have a function in neuronal differentiation and/or axon growth. Indicus|evm.model.CM009501.1.573 P49449 CENPA_BOVIN 100.000 0.985612 1.00725 CENPA - Histone H3-like centromeric protein A - Bos taurus (Bovine) - CENPA gene Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis. Indicus|evm.model.CM009501.1.574 Q5RFT1 S35F6_PONAB 94.340 0.994624 1.0027 SLC35F6 - Solute carrier family 35 member F6 precursor - Pongo abelii (Sumatran orangutan) - SLC35F6 gene Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity). Indicus|evm.model.CM009501.1.575 O14649 KCNK3_HUMAN 98.068 0.469248 1.11421 KCNK3 - Potassium channel subfamily K member 3 - Homo sapiens (Human) - KCNK3 gene pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Indicus|evm.model.CM009501.1.576 C7A278 CIB4_SHEEP 100.000 0.989247 1.00541 CIB4 - Calcium and integrin-binding family member 4 - Ovis aries (Sheep) - CIB4 gene calcium ion binding, magnesium ion binding Indicus|evm.model.CM009501.1.577 Q3SZR5 F166C_BOVIN 98.507 0.990099 1.00498 FAM166C - Protein FAM166C - Bos taurus (Bovine) - FAM166C gene Indicus|evm.model.CM009501.1.578 Q9ESF1 OTOF_MOUSE 94.344 0.998999 1.001 Otof - Otoferlin - Mus musculus (Mouse) - Otof gene Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes. Indicus|evm.model.CM009501.1.579 Q32KY1 DRC1_BOVIN 99.860 0.997195 1.0014 DRC1 - Dynein regulatory complex protein 1 - Bos taurus (Bovine) - DRC1 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Indicus|evm.model.CM009501.1.580 Q17QM4 EPT1_BOVIN 100.000 0.994832 0.974811 SELENOI - Ethanolaminephosphotransferase 1 - Bos taurus (Bovine) - SELENOI gene Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine/PE from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway. PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes. The enzyme is critical for the synthesis of several PE species and could also catalyze the synthesis of ether-linked phospholipids like plasmanyl- and plasmenyl-PE which could explain it is required for proper myelination and neurodevelopment. Indicus|evm.model.CM009501.1.581 Q8IZF5 AGRF3_HUMAN 70.724 0.919173 0.986098 ADGRF3 - Adhesion G-protein coupled receptor F3 precursor - Homo sapiens (Human) - ADGRF3 gene Orphan receptor. Indicus|evm.model.CM009501.1.582 O46629 ECHB_BOVIN 100.000 0.983402 1.01474 HADHB - Trifunctional enzyme subunit beta, mitochondrial precursor - Bos taurus (Bovine) - HADHB gene Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity. Indicus|evm.model.CM009501.1.583 Q29554 ECHA_PIG 90.301 0.997382 1.00131 HADHA - Trifunctional enzyme subunit alpha, mitochondrial precursor - Sus scrofa (Pig) - HADHA gene Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity. Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity. It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP. Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity. Indicus|evm.model.CM009501.1.584 Q75VX8 GARE2_HUMAN 88.558 0.915254 0.540046 GAREM2 - GRB2-associated and regulator of MAPK protein 2 - Homo sapiens (Human) - GAREM2 gene Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. Indicus|evm.model.CM009501.1.585 Q6PAJ3 GARE2_MOUSE 94.068 0.914062 0.145455 Garem2 - GRB2-associated and regulator of MAPK protein 2 - Mus musculus (Mouse) - Garem2 gene Probable adapter protein that provides a critical link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. Indicus|evm.model.CM009501.1.587 Q5R5U1 RAB10_PONAB 100.000 0.99005 1.005 RAB10 - Ras-related protein Rab-10 - Pongo abelii (Sumatran orangutan) - RAB10 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Plays also a specific role in asymmetric protein transport to the plasma membranes (By similarity). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane. In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (By similarity). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (By similarity). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (By similarity). When phosphorylated by LRRK2 on Thr-73, it binds RILPL1 and inhibits ciliogenesis (By similarity). Indicus|evm.model.CM009501.1.588 A0JN40 KIF3C_BOVIN 100.000 0.997478 1.00126 KIF3C - Kinesin-like protein KIF3C - Bos taurus (Bovine) - KIF3C gene Microtubule-based anterograde translocator for membranous organelles. Indicus|evm.model.CM009501.1.589 Q90YQ8 RS15A_ICTPU 92.105 0.889764 0.976923 rps15a - 40S ribosomal protein S15a - Ictalurus punctatus (Channel catfish) - rps15a gene Structural component of the ribosome. Indicus|evm.model.CM009501.1.590 Q76L83 ASXL2_HUMAN 85.842 0.998621 1.01045 ASXL2 - Putative Polycomb group protein ASXL2 - Homo sapiens (Human) - ASXL2 gene Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Indicus|evm.model.CM009501.1.591 O60941 DTNB_HUMAN 98.286 0.998095 0.837321 DTNB - Dystrobrevin beta - Homo sapiens (Human) - DTNB gene Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). Indicus|evm.model.CM009501.1.593 Q1LZ53 DNM3A_RAT 96.887 0.95297 0.889868 Dnmt3a - DNA (cytosine-5)-methyltransferase 3A - Rattus norvegicus (Rat) - Dnmt3a gene Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-706 in absence of DNA (By similarity). Indicus|evm.model.CM009501.1.595 P01190 COLI_BOVIN 99.623 0.992481 1.00377 POMC - Pro-opiomelanocortin precursor - Bos taurus (Bovine) - POMC gene Stimulates the adrenal glands to release cortisol. Indicus|evm.model.CM009501.1.596 Q9Y2G0 EFR3B_HUMAN 97.552 0.997555 1.00122 EFR3B - Protein EFR3 homolog B - Homo sapiens (Human) - EFR3B gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). Indicus|evm.model.CM009501.1.597 A5D7F5 DJC27_BOVIN 100.000 0.992701 1.00366 DNAJC27 - DnaJ homolog subfamily C member 27 - Bos taurus (Bovine) - DNAJC27 gene GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. Indicus|evm.model.CM009501.1.598 O60266 ADCY3_HUMAN 94.672 0.998255 1.00175 ADCY3 - Adenylate cyclase type 3 - Homo sapiens (Human) - ADCY3 gene Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. Indicus|evm.model.CM009501.1.599 Q3ZBK8 CENPO_BOVIN 99.662 0.993266 1.00338 CENPO - Centromere protein O - Bos taurus (Bovine) - CENPO gene Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex (By similarity). Indicus|evm.model.CM009501.1.600 Q3SZ85 PTRD1_BOVIN 100.000 0.985816 1.00714 PTRHD1 - Putative peptidyl-tRNA hydrolase PTRHD1 - Bos taurus (Bovine) - PTRHD1 gene Indicus|evm.model.CM009501.1.601 Q4PJW2 NCOA1_PIG 96.947 0.998613 1.00139 NCOA1 - Nuclear receptor coactivator 1 - Sus scrofa (Pig) - NCOA1 gene Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response (By similarity). Indicus|evm.model.CM009501.1.603 Q9NZM3 ITSN2_HUMAN 91.402 0.998791 0.974661 ITSN2 - Intersectin-2 - Homo sapiens (Human) - ITSN2 gene Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Indicus|evm.model.CM009501.1.604 Q32KQ1 F228A_BOVIN 100.000 0.46963 2.12264 FAM228A - Protein FAM228A - Bos taurus (Bovine) - FAM228A gene Indicus|evm.model.CM009501.1.605 Q2NKT1 PROF4_BOVIN 100.000 0.984615 1.00775 PFN4 - Profilin-4 - Bos taurus (Bovine) - PFN4 gene Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Indicus|evm.model.CM009501.1.606 Q53FA7 QORX_HUMAN 89.157 0.97929 1.01807 TP53I3 - Quinone oxidoreductase PIG3 - Homo sapiens (Human) - TP53I3 gene May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). Indicus|evm.model.CM009501.1.607 P59708 SF3B6_MOUSE 100.000 0.984127 1.008 Sf3b6 - Splicing factor 3B subunit 6 - Mus musculus (Mouse) - Sf3b6 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively. Indicus|evm.model.CM009501.1.608 P68106 FKB1B_HUMAN 100.000 0.981651 1.00926 FKBP1B - Peptidyl-prolyl cis-trans isomerase FKBP1B - Homo sapiens (Human) - FKBP1B gene Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Indicus|evm.model.CM009501.1.609 Q9H6R7 WDCP_HUMAN 73.615 0.968116 0.957004 WDCP - WD repeat and coiled-coil-containing protein - Homo sapiens (Human) - WDCP gene kinase binding, protein complex oligomerization Indicus|evm.model.CM009501.1.610 A6NFX1 MFS2B_HUMAN 84.355 0.94 0.992063 MFSD2B - Major facilitator superfamily domain-containing protein 2B - Homo sapiens (Human) - MFSD2B gene Cation-dependent lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Does not transport lysophosphatidylcholine (LPC) (By similarity). Indicus|evm.model.CM009501.1.611 P68543 UBX2A_HUMAN 90.310 0.992278 1 UBXN2A - UBX domain-containing protein 2A - Homo sapiens (Human) - UBXN2A gene cytosol, nucleus, ubiquitin binding, autophagosome assembly, Golgi organization, membrane fusion, nuclear envelope reassembly, proteasome-mediated ubiquitin-dependent protein catabolic process Indicus|evm.model.CM009501.1.612 Q9ULI0 ATD2B_HUMAN 96.982 0.998629 1.00069 ATAD2B - ATPase family AAA domain-containing protein 2B - Homo sapiens (Human) - ATAD2B gene nucleoplasm, nucleus, ATPase activity, chromatin binding, histone binding, lysine-acetylated histone binding, negative regulation of chromatin silencing, positive regulation of transcription by RNA polymerase II Indicus|evm.model.CM009501.1.613 Q96CT2 KLH29_HUMAN 96.457 0.968958 1.03086 KLHL29 - Kelch-like protein 29 - Homo sapiens (Human) - KLHL29 gene Indicus|evm.model.CM009501.1.617 Q5E983 EF1B_BOVIN 92.715 0.980392 0.68 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Indicus|evm.model.CM009501.1.618 P62268 RS23_RAT 95.105 0.934211 1.06294 Rps23 - 40S ribosomal protein S23 - Rattus norvegicus (Rat) - Rps23 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Indicus|evm.model.CM009501.1.619 B5MCY1 TDR15_HUMAN 76.983 0.326569 0.815408 TDRD15 - Tudor domain-containing protein 15 - Homo sapiens (Human) - TDRD15 gene Indicus|evm.model.CM009501.1.620 P17165 APOB_RABIT 80.556 0.0325074 30.5486 APOB - Apolipoprotein B - Oryctolagus cuniculus (Rabbit) - APOB gene Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Indicus|evm.model.CM009501.1.622 Q9H6V9 LDAH_HUMAN 78.769 0.993865 1.00308 LDAH - Lipid droplet-associated hydrolase - Homo sapiens (Human) - LDAH gene Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages. Indicus|evm.model.CM009501.1.623 P43029 GDF7_MOUSE 96.203 0.276596 0.611714 Gdf7 - Growth/differentiation factor 7 precursor - Mus musculus (Mouse) - Gdf7 gene extracellular region, extracellular space, cytokine activity, identical protein binding, activin receptor signaling pathway, axon guidance, BMP signaling pathway, branching morphogenesis of an epithelial tube, cell fate commitment, epithelial cell differentiation Indicus|evm.model.CM009501.1.624 Q53T59 H1BP3_HUMAN 77.041 0.98731 1.0051 HS1BP3 - HCLS1-binding protein 3 - Homo sapiens (Human) - HS1BP3 gene May be a modulator of IL-2 signaling. Indicus|evm.model.CM009501.1.625 P62747 RHOB_RAT 100.000 0.989848 1.0051 Rhob - Rho-related GTP-binding protein RhoB precursor - Rattus norvegicus (Rat) - Rhob gene Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells (By similarity). Indicus|evm.model.CM009501.1.627 Q80U58 PUM2_MOUSE 96.127 0.573604 0.924015 Pum2 - Pumilio homolog 2 - Mus musculus (Mouse) - Pum2 gene Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation. Plays a role in cytoplasmic sensing of viral infection. Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm. May regulate DCUN1D3 mRNA levels. May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (By similarity). Indicus|evm.model.CM009501.1.628 Q08DZ5 SDC1_BOVIN 100.000 0.99359 1.00322 SDC1 - Syndecan-1 precursor - Bos taurus (Bovine) - SDC1 gene Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Indicus|evm.model.CM009501.1.629 Q6QRN8 LAP4A_BOVIN 100.000 0.991453 1.00429 LAPTM4A - Lysosomal-associated transmembrane protein 4A - Bos taurus (Bovine) - LAPTM4A gene May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. Indicus|evm.model.CM009501.1.630 O15232 MATN3_HUMAN 88.063 0.776386 1.15021 MATN3 - Matrilin-3 precursor - Homo sapiens (Human) - MATN3 gene Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. Indicus|evm.model.CM009501.1.631 A6N6J5 WDR35_RAT 89.019 0.907278 0.857265 Wdr35 - WD repeat-containing protein 35 - Rattus norvegicus (Rat) - Wdr35 gene As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (By similarity). May promote CASP3 activation and TNF-stimulated apoptosis (PubMed:20193664). Indicus|evm.model.CM009501.1.632 Q5I0X7 TTC32_HUMAN 87.755 0.979866 0.986755 TTC32 - Tetratricopeptide repeat protein 32 - Homo sapiens (Human) - TTC32 gene Indicus|evm.model.CM009501.1.634 Q08DS3 OSR1_BOVIN 100.000 0.992537 1.00375 OSR1 - Protein odd-skipped-related 1 - Bos taurus (Bovine) - OSR1 gene Transcription factor that plays a role in the regulation of embryonic heart and urogenital development. Indicus|evm.model.CM009501.1.635 Q91YE9 5NT1B_MOUSE 71.134 0.99646 0.986038 Nt5c1b - Cytosolic 5'-nucleotidase 1B - Mus musculus (Mouse) - Nt5c1b gene Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels. Indicus|evm.model.CM009501.1.636 Q17QW3 RDH14_BOVIN 99.702 0.994065 1.00298 RDH14 - Retinol dehydrogenase 14 - Bos taurus (Bovine) - RDH14 gene Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroid. Indicus|evm.model.CM009501.1.637 Q9TT17 KCNS3_RABIT 96.516 0.989837 1.00204 KCNS3 - Potassium voltage-gated channel subfamily S member 3 - Oryctolagus cuniculus (Rabbit) - KCNS3 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Indicus|evm.model.CM009501.1.638 A6NI15 MSGN1_HUMAN 87.047 0.989691 1.00518 MSGN1 - Mesogenin-1 - Homo sapiens (Human) - MSGN1 gene Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity). Indicus|evm.model.CM009501.1.639 Q17RS7 GEN_HUMAN 75.915 0.997625 0.927313 GEN1 - Flap endonuclease GEN homolog 1 - Homo sapiens (Human) - GEN1 gene Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation (PubMed:19020614, PubMed:26682650). Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction (PubMed:26578604). Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA (PubMed:28049850). Has also endonuclease activity on 5'-flap and replication fork (RF) DNA substrates (PubMed:26578604). Indicus|evm.model.CM009501.1.640 Q96SB8 SMC6_HUMAN 91.431 0.99727 1.00733 SMC6 - Structural maintenance of chromosomes protein 6 - Homo sapiens (Human) - SMC6 gene Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). Indicus|evm.model.CM009501.1.641 P62762 VISL1_RAT 100.000 0.818966 1.21466 Vsnl1 - Visinin-like protein 1 - Rattus norvegicus (Rat) - Vsnl1 gene Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. Indicus|evm.model.CM009501.1.642 Q09MP3 R51A2_HUMAN 64.122 0.35576 0.936152 RAD51AP2 - RAD51-associated protein 2 - Homo sapiens (Human) - RAD51AP2 gene protein-containing complex, double-stranded DNA binding, single-stranded DNA binding, double-strand break repair via homologous recombination, interstrand cross-link repair Indicus|evm.model.CM009501.1.644 Q5R6L2 CYRIA_PONAB 100.000 0.993827 1.0031 CYRIA - CYFIP-related Rac1 interactor A - Pongo abelii (Sumatran orangutan) - CYRIA gene May negatively regulate RAC1 signaling and RAC1-driven cytoskeletal remodeling. May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Indicus|evm.model.CM009501.1.645 P04198 MYCN_HUMAN 93.833 0.71746 0.678879 MYCN - N-myc proto-oncogene protein - Homo sapiens (Human) - MYCN gene Positively regulates the transcription of MYCNOS in neuroblastoma cells. Indicus|evm.model.CM009501.1.648 Q0IIK5 DDX1_BOVIN 100.000 0.98 1.01351 DDX1 - ATP-dependent RNA helicase DDX1 - Bos taurus (Bovine) - DDX1 gene Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). Indicus|evm.model.CM009501.1.649 A2RRP1 NBAS_HUMAN 93.590 0.378221 0.867566 NBAS - Neuroblastoma-amplified sequence - Homo sapiens (Human) - NBAS gene Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Indicus|evm.model.CM009501.1.650 Q3ZCA1 LRAT1_BOVIN 100.000 0.993289 1.00337 LRATD1 - Protein LRATD1 - Bos taurus (Bovine) - LRATD1 gene May play a role in cell morphology and motility. Indicus|evm.model.CM009501.1.652 Q13309 SKP2_HUMAN 90.446 0.987342 0.372642 SKP2 - S-phase kinase-associated protein 2 - Homo sapiens (Human) - SKP2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Indicus|evm.model.CM009501.1.653 Q5GLH2 TRIB2_BOVIN 100.000 0.994186 1.00292 TRIB2 - Tribbles homolog 2 - Bos taurus (Bovine) - TRIB2 gene Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Indicus|evm.model.CM009501.1.654 Q91ZP3 LPIN1_MOUSE 85.134 0.912957 1.09416 Lpin1 - Phosphatidate phosphatase LPIN1 - Mus musculus (Mouse) - Lpin1 gene Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:17158099). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Indicus|evm.model.CM009501.1.655 O95665 NTR2_HUMAN 80.153 0.941176 0.995122 NTSR2 - Neurotensin receptor type 2 - Homo sapiens (Human) - NTSR2 gene Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009501.1.656 Q4ZG55 GREB1_HUMAN 90.932 0.969062 1.02822 GREB1 - Protein GREB1 - Homo sapiens (Human) - GREB1 gene May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. Indicus|evm.model.CM009501.1.657 Q08DY6 E2F6_BOVIN 97.917 0.99308 1.01404 E2F6 - Transcription factor E2F6 - Bos taurus (Bovine) - E2F6 gene Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains (By similarity). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (By similarity). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity). Indicus|evm.model.CM009501.1.658 Q28021 ROCK2_BOVIN 98.891 0.970482 1.00072 ROCK2 - Rho-associated protein kinase 2 - Bos taurus (Bovine) - ROCK2 gene Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. Indicus|evm.model.CM009501.1.659 Q8N755 S66A3_HUMAN 82.323 0.975248 1 SLC66A3 - Solute carrier family 66 member 3 precursor - Homo sapiens (Human) - SLC66A3 gene Indicus|evm.model.CM009501.1.660 Q1JPL0 CB050_BOVIN 98.089 0.987342 1.00637 Uncharacterized protein C2orf50 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009501.1.661 Q9H3M0 KCNF1_HUMAN 96.364 0.995968 1.00405 KCNF1 - Potassium voltage-gated channel subfamily F member 1 - Homo sapiens (Human) - KCNF1 gene Putative voltage-gated potassium channel. Indicus|evm.model.CM009501.1.662 Q922R8 PDIA6_MOUSE 95.909 0.995465 1.00227 Pdia6 - Protein disulfide-isomerase A6 precursor - Mus musculus (Mouse) - Pdia6 gene May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:24508390). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (By similarity). May also regulate the UPR via the EIF2AK3 UPR sensor (By similarity). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity). Indicus|evm.model.CM009501.1.663 Q8NEY4 VATC2_HUMAN 94.145 0.995327 1.00234 ATP6V1C2 - V-type proton ATPase subunit C 2 - Homo sapiens (Human) - ATP6V1C2 gene Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Indicus|evm.model.CM009501.1.664 Q9BSC4 NOL10_HUMAN 90.262 0.99689 0.934593 NOL10 - Nucleolar protein 10 - Homo sapiens (Human) - NOL10 gene nucleolus, small-subunit processome, RNA binding, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009501.1.666 P27117 DCOR_BOVIN 100.000 0.995671 1.00217 ODC1 - Ornithine decarboxylase - Bos taurus (Bovine) - ODC1 gene Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Indicus|evm.model.CM009501.1.667 B3VSB7 HPCL1_SHEEP 100.000 0.989691 1.00518 HPCAL1 - Hippocalcin-like protein 1 - Ovis aries (Sheep) - HPCAL1 gene May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Indicus|evm.model.CM009501.1.670 P31350 RIR2_HUMAN 94.602 0.994872 1.00257 RRM2 - Ribonucleoside-diphosphate reductase subunit M2 - Homo sapiens (Human) - RRM2 gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Indicus|evm.model.CM009501.1.671 Q717R9 CYS1_HUMAN 70.732 0.430108 0.588608 CYS1 - Cystin-1 - Homo sapiens (Human) - CYS1 gene cilium, cytosol, cilium assembly Indicus|evm.model.CM009501.1.672 Q9Y2Y9 KLF13_HUMAN 77.907 0.167984 1.75694 KLF13 - Krueppel-like factor 13 - Homo sapiens (Human) - KLF13 gene Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. Indicus|evm.model.CM009501.1.673 Q9NZI5 GRHL1_HUMAN 91.252 0.996569 0.943366 GRHL1 - Grainyhead-like protein 1 homolog - Homo sapiens (Human) - GRHL1 gene Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Indicus|evm.model.CM009501.1.674 Q1JQD6 TAF1B_BOVIN 87.458 0.996248 0.90339 TAF1B - TATA box-binding protein-associated factor RNA polymerase I subunit B - Bos taurus (Bovine) - TAF1B gene Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3 (By similarity). Indicus|evm.model.CM009501.1.675 Q5RFJ2 1433T_PONAB 100.000 0.99187 1.00408 YWHAQ - 14-3-3 protein theta - Pongo abelii (Sumatran orangutan) - YWHAQ gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). Indicus|evm.model.CM009501.1.676 O77636 ADA17_PIG 99.107 0.134383 7.375 ADAM17 - Disintegrin and metalloproteinase domain-containing protein 17 - Sus scrofa (Pig) - ADAM17 gene Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (By similarity). Indicus|evm.model.CM009501.1.677 Q3SZ16 IAH1_BOVIN 100.000 0.992 1.00402 IAH1 - Isoamyl acetate-hydrolyzing esterase 1 homolog - Bos taurus (Bovine) - IAH1 gene Probable lipase. Indicus|evm.model.CM009501.1.678 P79101 CPSF3_BOVIN 100.000 0.99708 1.00146 CPSF3 - Cleavage and polyadenylation specificity factor subunit 3 - Bos taurus (Bovine) - CPSF3 gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Indicus|evm.model.CM009501.1.679 Q3ZBM4 ITBP1_BOVIN 99.500 0.99005 1.005 ITGB1BP1 - Integrin beta-1-binding protein 1 - Bos taurus (Bovine) - ITGB1BP1 gene Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter (By similarity). Indicus|evm.model.CM009501.1.680 Q7SIG6 ASAP2_MOUSE 88.324 0.997833 0.963466 Asap2 - Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 - Mus musculus (Mouse) - Asap2 gene Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration (By similarity). Indicus|evm.model.CM009501.1.682 Q6ZWT7 MBOA2_HUMAN 85.253 0.995745 0.903846 MBOAT2 - Lysophospholipid acyltransferase 2 - Homo sapiens (Human) - MBOAT2 gene Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Catalyzes preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS) (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor (PubMed:18772128). May be involved in chondrocyte differentiation (By similarity). Indicus|evm.model.CM009501.1.683 Q9ULH0 KDIS_HUMAN 94.706 0.985476 0.777527 KIDINS220 - Kinase D-interacting substrate of 220 kDa - Homo sapiens (Human) - KIDINS220 gene Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. Indicus|evm.model.CM009501.1.685 Q3ZC46 ID2_BOVIN 100.000 0.985185 1.00746 ID2 - DNA-binding protein inhibitor ID-2 - Bos taurus (Bovine) - ID2 gene Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity). Indicus|evm.model.CM009501.1.686 Q4R7Y2 RL10_MACFA 58.667 0.45122 0.766355 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009501.1.688 Q99877 H2B1N_HUMAN 89.655 0.92 0.992063 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009501.1.689 Q9NR30 DDX21_HUMAN 82.456 0.302703 0.236271 DDX21 - Nucleolar RNA helicase 2 - Homo sapiens (Human) - DDX21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Indicus|evm.model.CM009501.1.693 Q925F3 R144A_MOUSE 94.198 0.957377 1.04452 Rnf144a - E3 ubiquitin-protein ligase RNF144A - Mus musculus (Mouse) - Rnf144a gene E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC. Indicus|evm.model.CM009501.1.694 Q2HJF9 RSAD2_BOVIN 100.000 0.994505 1.00275 RSAD2 - Radical S-adenosyl methionine domain-containing protein 2 - Bos taurus (Bovine) - RSAD2 gene Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyszes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses. Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. Indicus|evm.model.CM009501.1.695 Q5EBM0 CMPK2_HUMAN 83.228 0.844504 0.830735 CMPK2 - UMP-CMP kinase 2, mitochondrial precursor - Homo sapiens (Human) - CMPK2 gene May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. Indicus|evm.model.CM009501.1.698 Q7M6Y2 SOX11_MOUSE 100.000 0.101083 0.701266 Sox11 - Transcription factor SOX-11 - Mus musculus (Mouse) - Sox11 gene Transcription factor that acts as a transcriptional activator (PubMed:18505825, PubMed:18403418). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (PubMed:18505825, PubMed:18403418). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (PubMed:20596238). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (PubMed:20596238). Indicus|evm.model.CM009501.1.699 Q9UNH6 SNX7_HUMAN 88.591 0.986667 0.775194 SNX7 - Sorting nexin-7 - Homo sapiens (Human) - SNX7 gene May be involved in several stages of intracellular trafficking. Indicus|evm.model.CM009501.1.704 G3V9Q9 GTA1L_RAT 64.214 0.916149 1.00312 Ggta1l1 - N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1 - Rattus norvegicus (Rat) - Ggta1l1 gene Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Indicus|evm.model.CM009501.1.705 Q8HYB2 GGTA1_LEMCA 66.667 0.862275 0.890667 GGTA1 - N-acetyllactosaminide alpha-1,3-galactosyltransferase - Lemur catta (Ring-tailed lemur) - GGTA1 gene Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isogloboside 3 (iGb3) (By similarity). Indicus|evm.model.CM009501.1.706 P14769 GGTA1_BOVIN 99.728 0.87381 1.1413 GGTA1 - N-acetyllactosaminide alpha-1,3-galactosyltransferase - Bos taurus (Bovine) - GGTA1 gene Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3). Indicus|evm.model.CM009501.1.708 Q3UHC7 DAB2P_MOUSE 89.130 0.335821 0.1127 Dab2ip - Disabled homolog 2-interacting protein - Mus musculus (Mouse) - Dab2ip gene Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. Indicus|evm.model.CM009501.1.709 Q3UHC7 DAB2P_MOUSE 98.760 0.223562 0.906644 Dab2ip - Disabled homolog 2-interacting protein - Mus musculus (Mouse) - Dab2ip gene Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. Indicus|evm.model.CM009501.1.710 Q8NHH1 TTL11_HUMAN 85.854 0.909228 0.82625 TTLL11 - Tubulin polyglutamylase TTLL11 - Homo sapiens (Human) - TTLL11 gene Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Generates long side-chains (By similarity). Indicus|evm.model.CM009501.1.711 P42029 NDUA8_BOVIN 100.000 0.988439 1.00581 NDUFA8 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 - Bos taurus (Bovine) - NDUFA8 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009501.1.712 Q32LL6 MORN5_BOVIN 100.000 0.988439 1.00581 MORN5 - MORN repeat-containing protein 5 - Bos taurus (Bovine) - MORN5 gene Indicus|evm.model.CM009501.1.713 Q9UPM6 LHX6_HUMAN 98.611 0.834884 1.18457 LHX6 - LIM/homeobox protein Lhx6 - Homo sapiens (Human) - LHX6 gene Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity). Indicus|evm.model.CM009501.1.714 Q3ZCC5 RBM18_BOVIN 100.000 0.989529 1.00526 RBM18 - Probable RNA-binding protein 18 - Bos taurus (Bovine) - RBM18 gene RNA binding Indicus|evm.model.CM009501.1.715 Q0VCQ4 RRFM_BOVIN 96.855 0.542955 1.11069 MRRF - Ribosome-recycling factor, mitochondrial precursor - Bos taurus (Bovine) - MRRF gene Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity). Indicus|evm.model.CM009501.1.716 Q0VCQ4 RRFM_BOVIN 100.000 0.885246 0.465649 MRRF - Ribosome-recycling factor, mitochondrial precursor - Bos taurus (Bovine) - MRRF gene Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity). Indicus|evm.model.CM009501.1.717 O62664 PGH1_BOVIN 99.333 0.996672 1.00167 PTGS1 - Prostaglandin G/H synthase 1 precursor - Bos taurus (Bovine) - PTGS1 gene Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. Indicus|evm.model.CM009501.1.718 Q6ZRY4 RBPS2_HUMAN 82.418 0.616438 0.698565 RBPMS2 - RNA-binding protein with multiple splicing 2 - Homo sapiens (Human) - RBPMS2 gene RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:25064856). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity). Indicus|evm.model.CM009501.1.721 Q8NGR6 OR1B1_HUMAN 79.866 0.983444 0.949686 OR1B1 - Olfactory receptor 1B1 - Homo sapiens (Human) - OR1B1 gene Odorant receptor. Indicus|evm.model.CM009501.1.722 Q8NGR5 OR1L4_HUMAN 86.174 0.99359 1.00322 OR1L4 - Olfactory receptor 1L4 - Homo sapiens (Human) - OR1L4 gene Odorant receptor. Indicus|evm.model.CM009501.1.723 P79103 RS4_BOVIN 82.890 0.991453 0.889734 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009501.1.724 Q2HJA9 PHLP_BOVIN 100.000 0.993377 1.00332 PDCL - Phosducin-like protein - Bos taurus (Bovine) - PDCL gene Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function. Indicus|evm.model.CM009501.1.725 Q9HBD1 RC3H2_HUMAN 97.229 0.998319 0.99916 RC3H2 - Roquin-2 - Homo sapiens (Human) - RC3H2 gene Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670) (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). Indicus|evm.model.CM009501.1.727 Q0V8G8 ZBTB6_BOVIN 100.000 0.813462 1.22642 ZBTB6 - Zinc finger and BTB domain-containing protein 6 - Bos taurus (Bovine) - ZBTB6 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009501.1.728 Q9HCK0 ZBT26_HUMAN 99.093 0.995475 1.00227 ZBTB26 - Zinc finger and BTB domain-containing protein 26 - Homo sapiens (Human) - ZBTB26 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009501.1.729 Q5RAN1 RBGP1_PONAB 98.410 0.998131 1.00094 RABGAP1 - Rab GTPase-activating protein 1 - Pongo abelii (Sumatran orangutan) - RABGAP1 gene May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition (By similarity). Indicus|evm.model.CM009501.1.731 Q08E27 STRBP_BOVIN 100.000 0.996918 0.965774 STRBP - Spermatid perinuclear RNA-binding protein - Bos taurus (Bovine) - STRBP gene Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). Indicus|evm.model.CM009501.1.732 Q5IJ48 CRUM2_HUMAN 85.417 0.147683 0.990661 CRB2 - Protein crumbs homolog 2 precursor - Homo sapiens (Human) - CRB2 gene Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo (By similarity). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (By similarity). The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB (By similarity). Plays a role in the maintenance of retinal neuroepithelium organization, structural integrity, adhesion, photoreceptor polarity and retinal photoreceptor layer thickness (By similarity). May play a role in determining the length of cone photoreceptor outer segments and proliferation of late-born progenitor cells (By similarity). Also required for maintenance of the apical polarity complex during development of the cortex (By similarity). Inhibits gamma-secretase-dependent cleavage of APP and secretion of amyloid-beta peptide 40 and amyloid-beta peptide 42, and thereby inhibits gamma-secretase-dependent Notch transcription (PubMed:20299451). Indicus|evm.model.CM009501.1.733 Q8TEH3 DEN1A_HUMAN 89.733 0.998014 0.998018 DENND1A - DENN domain-containing protein 1A - Homo sapiens (Human) - DENND1A gene Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). Indicus|evm.model.CM009501.1.734 P50458 LHX2_HUMAN 99.754 0.995086 1.00246 LHX2 - LIM/homeobox protein Lhx2 - Homo sapiens (Human) - LHX2 gene Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). Indicus|evm.model.CM009501.1.735 A2BD05 NEK6_PIG 98.083 0.993631 1.00319 NEK6 - Serine/threonine-protein kinase Nek6 - Sus scrofa (Pig) - NEK6 gene Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (By similarity). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity). Indicus|evm.model.CM009501.1.736 Q2TBP0 PSB7_BOVIN 99.639 0.992806 1.00361 PSMB7 - Proteasome subunit beta type-7 precursor - Bos taurus (Bovine) - PSMB7 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity. Indicus|evm.model.CM009501.1.737 Q7Z7M1 AGRD2_HUMAN 75.480 0.863469 1.12565 ADGRD2 - Adhesion G-protein coupled receptor D2 - Homo sapiens (Human) - ADGRD2 gene Orphan receptor. Indicus|evm.model.CM009501.1.738 Q04752 STF1_BOVIN 100.000 0.995671 1.00217 NR5A1 - Steroidogenic factor 1 - Bos taurus (Bovine) - NR5A1 gene Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity). Indicus|evm.model.CM009501.1.739 A0P8Z4 NR6A1_PIG 99.076 0.981818 0.91858 NR6A1 - Nuclear receptor subfamily 6 group A member 1 - Sus scrofa (Pig) - NR6A1 gene Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). Indicus|evm.model.CM009501.1.740 A2BD09 OLM2A_PIG 92.960 0.946646 1.00923 OLFML2A - Olfactomedin-like protein 2A precursor - Sus scrofa (Pig) - OLFML2A gene Indicus|evm.model.CM009501.1.741 Q5JTN6 WDR38_HUMAN 79.730 0.993266 0.94586 WDR38 - WD repeat-containing protein 38 - Homo sapiens (Human) - WDR38 gene Indicus|evm.model.CM009501.1.742 Q3MHM7 RL35_BOVIN 100.000 0.983871 1.00813 RPL35 - 60S ribosomal protein L35 - Bos taurus (Bovine) - RPL35 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009501.1.743 Q5E963 ARP5L_BOVIN 100.000 0.461883 1.45752 ARPC5L - Actin-related protein 2/3 complex subunit 5-like protein - Bos taurus (Bovine) - ARPC5L gene May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Indicus|evm.model.CM009501.1.744 Q92805 GOGA1_HUMAN 85.807 0.92615 1.07692 GOLGA1 - Golgin subfamily A member 1 - Homo sapiens (Human) - GOLGA1 gene Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Indicus|evm.model.CM009501.1.745 Q8N9R8 SCAI_HUMAN 99.670 0.996705 1.00165 SCAI - Protein SCAI - Homo sapiens (Human) - SCAI gene Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. Indicus|evm.model.CM009501.1.746 O00743 PPP6_HUMAN 100.000 0.993464 1.00328 PPP6C - Serine/threonine-protein phosphatase 6 catalytic subunit - Homo sapiens (Human) - PPP6C gene Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation (PubMed:29053956). Indicus|evm.model.CM009501.1.747 Q5EA50 RABEK_BOVIN 100.000 0.994638 1.00269 RABEPK - Rab9 effector protein with kelch motifs - Bos taurus (Bovine) - RABEPK gene Rab9 effector required for endosome to trans-Golgi network (TGN) transport. Indicus|evm.model.CM009501.1.748 Q0VCX2 BIP_BOVIN 100.000 0.615385 0.89313 HSPA5 - Endoplasmic reticulum chaperone BiP precursor - Bos taurus (Bovine) - HSPA5 gene Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity). Indicus|evm.model.CM009501.1.749 Q14C86 GAPD1_HUMAN 97.566 0.998632 0.989175 GAPVD1 - GTPase-activating protein and VPS9 domain-containing protein 1 - Homo sapiens (Human) - GAPVD1 gene Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. Indicus|evm.model.CM009501.1.751 P40426 PBX3_HUMAN 100.000 0.994444 0.829493 PBX3 - Pre-B-cell leukemia transcription factor 3 - Homo sapiens (Human) - PBX3 gene Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Indicus|evm.model.CM009501.1.752 Q9H7P6 MB12B_HUMAN 98.288 0.836207 1.09091 MVB12B - Multivesicular body subunit 12B - Homo sapiens (Human) - MVB12B gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. Indicus|evm.model.CM009501.1.753 Q60564 LMX1B_MESAU 96.825 0.369048 0.455285 LMX1B - LIM homeobox transcription factor 1-beta - Mesocricetus auratus (Golden hamster) - LMX1B gene Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Mediates physical interaction and transcriptional synergy with E47/PAN-1. Indicus|evm.model.CM009501.1.754 O88609 LMX1B_MOUSE 99.576 0.851449 0.698734 Lmx1b - LIM homeobox transcription factor 1-beta - Mus musculus (Mouse) - Lmx1b gene Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Indicus|evm.model.CM009501.1.755 O43298 ZBT43_HUMAN 98.069 0.931864 1.06852 ZBTB43 - Zinc finger and BTB domain-containing protein 43 - Homo sapiens (Human) - ZBTB43 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009501.1.756 Q8NCN2 ZBT34_HUMAN 96.813 0.969052 1.034 ZBTB34 - Zinc finger and BTB domain-containing protein 34 - Homo sapiens (Human) - ZBTB34 gene May be a transcriptional repressor. Indicus|evm.model.CM009501.1.758 A2AR50 RGPS1_MOUSE 96.296 0.974182 0.993162 Ralgps1 - Ras-specific guanine nucleotide-releasing factor RalGPS1 - Mus musculus (Mouse) - Ralgps1 gene Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeleton organization. Indicus|evm.model.CM009501.1.759 Q3V0G7 GARL3_MOUSE 83.333 0.489583 0.0924855 Garnl3 - GTPase-activating Rap/Ran-GAP domain-like protein 3 - Mus musculus (Mouse) - Garnl3 gene cytoplasm, GTPase activator activity, activation of GTPase activity Indicus|evm.model.CM009501.1.760 Q5VVW2 GARL3_HUMAN 93.946 0.995976 0.981244 GARNL3 - GTPase-activating Rap/Ran-GAP domain-like protein 3 - Homo sapiens (Human) - GARNL3 gene cytoplasm, GTPase activator activity, activation of GTPase activity Indicus|evm.model.CM009501.1.761 P58354 GTR8_BOVIN 99.791 0.995825 1.00209 SLC2A8 - Solute carrier family 2, facilitated glucose transporter member 8 - Bos taurus (Bovine) - SLC2A8 gene Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate. Indicus|evm.model.CM009501.1.762 P30050 RL12_HUMAN 100.000 0.987952 1.00606 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Indicus|evm.model.CM009501.1.763 Q6UWE0 LRSM1_HUMAN 91.172 0.997241 1.00277 LRSAM1 - E3 ubiquitin-protein ligase LRSAM1 - Homo sapiens (Human) - LRSAM1 gene E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). Indicus|evm.model.CM009501.1.764 B4F7E8 NIBA2_RAT 91.310 0.997319 0.998661 Niban2 - Protein Niban 2 - Rattus norvegicus (Rat) - Niban2 gene May play a role in apoptosis suppression. Indicus|evm.model.CM009501.1.765 P61765 STXB1_RAT 100.000 0.996639 1.00168 Stxbp1 - Syntaxin-binding protein 1 - Rattus norvegicus (Rat) - Stxbp1 gene Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (PubMed:21689256). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Indicus|evm.model.CM009501.1.766 Q5JU67 CF157_HUMAN 70.476 0.996176 1.00577 CFAP157 - Cilia- and flagella-associated protein 157 - Homo sapiens (Human) - CFAP157 gene Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure. Indicus|evm.model.CM009501.1.767 Q86Y79 PTH_HUMAN 82.857 0.972093 1.00467 PTRH1 - Probable peptidyl-tRNA hydrolase - Homo sapiens (Human) - PTRH1 gene aminoacyl-tRNA hydrolase activity, RNA binding Indicus|evm.model.CM009501.1.768 Q8NEE8 TTC16_HUMAN 63.933 0.885279 1.12829 TTC16 - Tetratricopeptide repeat protein 16 - Homo sapiens (Human) - TTC16 gene Indicus|evm.model.CM009501.1.769 A4FUH1 TOR2A_BOVIN 100.000 0.993789 1.00312 TOR2A - Torsin-2A precursor - Bos taurus (Bovine) - TOR2A gene Indicus|evm.model.CM009501.1.770 Q8N5H7 SH2D3_HUMAN 90.692 0.972125 1.00116 SH2D3C - SH2 domain-containing protein 3C - Homo sapiens (Human) - SH2D3C gene Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). Indicus|evm.model.CM009501.1.771 Q5EAB2 CDK9_BOVIN 100.000 0.994638 1.00269 CDK9 - Cyclin-dependent kinase 9 - Bos taurus (Bovine) - CDK9 gene Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation. Indicus|evm.model.CM009501.1.772 A6H751 FOLC_BOVIN 99.766 0.617391 1.17949 FPGS - Folylpolyglutamate synthase, mitochondrial precursor - Bos taurus (Bovine) - FPGS gene Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Indicus|evm.model.CM009501.1.773 A6H751 FOLC_BOVIN 98.496 0.26087 0.864957 FPGS - Folylpolyglutamate synthase, mitochondrial precursor - Bos taurus (Bovine) - FPGS gene Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Indicus|evm.model.CM009501.1.774 P00570 KAD1_BOVIN 100.000 0.989744 1.00515 AK1 - Adenylate kinase isoenzyme 1 - Bos taurus (Bovine) - AK1 gene Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Indicus|evm.model.CM009501.1.775 Q08E15 SIA7F_BOVIN 98.780 0.893443 1.10241 ST6GALNAC6 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 - Bos taurus (Bovine) - ST6GALNAC6 gene Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (By similarity). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity). Indicus|evm.model.CM009501.1.776 Q9H4F1 SIA7D_HUMAN 90.728 0.833795 1.19536 ST6GALNAC4 - Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase - Homo sapiens (Human) - ST6GALNAC4 gene Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. Prefers O-glycans to glycoproteins or glycolipids. Indicus|evm.model.CM009501.1.777 Q17QS4 PI5L1_BOVIN 91.169 0.869023 1.21465 PIP5KL1 - Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 - Bos taurus (Bovine) - PIP5KL1 gene May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. Indicus|evm.model.CM009501.1.778 Q2KIN1 DPM2_BOVIN 97.059 0.51145 1.55952 DPM2 - Dolichol phosphate-mannose biosynthesis regulatory protein - Bos taurus (Bovine) - DPM2 gene Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex. Indicus|evm.model.CM009501.1.779 Q5T9C2 F102A_HUMAN 96.094 0.922705 1.07812 FAM102A - Protein FAM102A - Homo sapiens (Human) - FAM102A gene May play a role in estrogen action. Indicus|evm.model.CM009501.1.780 A7MBH3 NAIF1_BOVIN 100.000 0.993902 1.00306 NAIF1 - Nuclear apoptosis-inducing factor 1 - Bos taurus (Bovine) - NAIF1 gene Induces apoptosis. Indicus|evm.model.CM009501.1.781 Q0V7M4 SCMC2_BOVIN 99.760 0.828685 1.07036 SLC25A25 - Calcium-binding mitochondrial carrier protein SCaMC-2 - Bos taurus (Bovine) - SLC25A25 gene Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity). Indicus|evm.model.CM009501.1.783 Q66LN0 PGES2_BOVIN 100.000 0.994638 1.00269 PTGES2 - Prostaglandin E synthase 2 - Bos taurus (Bovine) - PTGES2 gene Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:10446427, PubMed:11866447). The biological function and the GSH-dependent property of PTGES2 is still under debate (By similarity). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity). Indicus|evm.model.CM009501.1.784 P80188 NGAL_HUMAN 68.715 0.89 1.0101 LCN2 - Neutrophil gelatinase-associated lipocalin precursor - Homo sapiens (Human) - LCN2 gene Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368). Indicus|evm.model.CM009501.1.785 Q2NKS9 BBLN_BOVIN 100.000 0.97619 1.01205 BBLN - Bublin coiled-coil protein - Bos taurus (Bovine) - BBLN gene Indicus|evm.model.CM009501.1.786 Q9ULV3 CIZ1_HUMAN 76.484 0.981154 0.945434 CIZ1 - Cip1-interacting zinc finger protein - Homo sapiens (Human) - CIZ1 gene May regulate the subcellular localization of CIP/WAF1. Indicus|evm.model.CM009501.1.787 Q05193 DYN1_HUMAN 99.763 0.989437 0.986111 DNM1 - Dynamin-1 - Homo sapiens (Human) - DNM1 gene Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. Indicus|evm.model.CM009501.1.788 H3BPF8 GOG8S_HUMAN 73.684 0.054211 1.6528 GOLGA8S - Golgin subfamily A member 8S - Homo sapiens (Human) - GOLGA8S gene cis-Golgi network, Golgi cis cisterna, Golgi cisterna membrane, Golgi organization Indicus|evm.model.CM009501.1.789 Q1ZZU3 SWI5_HUMAN 86.022 0.938776 0.417021 SWI5 - DNA repair protein SWI5 homolog - Homo sapiens (Human) - SWI5 gene Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Indicus|evm.model.CM009501.1.790 O95900 TRUB2_HUMAN 86.103 0.993976 1.00302 TRUB2 - Mitochondrial mRNA pseudouridine synthase TRUB2 precursor - Homo sapiens (Human) - TRUB2 gene Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Indicus|evm.model.CM009501.1.791 Q05B52 COQ4_BOVIN 97.810 0.511278 1.76159 COQ4 - Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial precursor - Bos taurus (Bovine) - COQ4 gene Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides (By similarity). Indicus|evm.model.CM009501.1.792 Q5RDY4 S27A4_PONAB 88.958 0.996894 1.00156 SLC27A4 - Long-chain fatty acid transport protein 4 - Pongo abelii (Sumatran orangutan) - SLC27A4 gene Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs) (By similarity). Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (By similarity). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). Indicus|evm.model.CM009501.1.793 A9YUB5 URM1_CAPHI 100.000 0.980392 1.0099 URM1 - Ubiquitin-related modifier 1 - Capra hircus (Goat) - URM1 gene Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. Indicus|evm.model.CM009501.1.794 A8D8X1 RL10_SHEEP 68.868 0.689655 0.67757 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009501.1.795 A7MB73 GT253_BOVIN 99.420 0.996139 0.870588 CERCAM - Probable inactive glycosyltransferase 25 family member 3 precursor - Bos taurus (Bovine) - CERCAM gene Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro. Indicus|evm.model.CM009501.1.796 Q2T9U2 ODFP2_BOVIN 98.522 0.632292 1.46119 ODF2 - Outer dense fiber protein 2 - Bos taurus (Bovine) - ODF2 gene Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly (By similarity). Indicus|evm.model.CM009501.1.797 Q3ZBK7 GLE1_BOVIN 100.000 0.997139 1.00143 GLE1 - Nucleoporin GLE1 - Bos taurus (Bovine) - GLE1 gene Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). Indicus|evm.model.CM009501.1.798 Q13813 SPTN1_HUMAN 99.150 0.994366 1.00526 SPTAN1 - Spectrin alpha chain, non-erythrocytic 1 - Homo sapiens (Human) - SPTAN1 gene Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Indicus|evm.model.CM009501.1.799 Q5U4F6 DC2I2_MOUSE 84.325 0.934823 1 Dync2i2 - Cytoplasmic dynein 2 intermediate chain 2 - Mus musculus (Mouse) - Dync2i2 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis (PubMed:28379358). Required also to maintain a functional transition zone (By similarity). Indicus|evm.model.CM009501.1.800 Q01105 SET_HUMAN 91.213 0.808874 1.01034 SET - Protein SET - Homo sapiens (Human) - SET gene Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Indicus|evm.model.CM009501.1.801 Q6P5Z2 PKN3_HUMAN 90.101 0.997753 1.00112 PKN3 - Serine/threonine-protein kinase N3 - Homo sapiens (Human) - PKN3 gene Contributes to invasiveness in malignant prostate cancer. Indicus|evm.model.CM009501.1.802 Q96GR4 ZDH12_HUMAN 93.657 0.992565 1.00749 ZDHHC12 - Palmitoyltransferase ZDHHC12 - Homo sapiens (Human) - ZDHHC12 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmission. Indicus|evm.model.CM009501.1.803 Q5RAG3 ZER1_PONAB 98.303 0.997392 1.00131 ZER1 - Protein zer-1 homolog - Pongo abelii (Sumatran orangutan) - ZER1 gene Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation. Indicus|evm.model.CM009501.1.804 Q9NVG8 TBC13_HUMAN 96.000 0.995 1 TBC1D13 - TBC1 domain family member 13 - Homo sapiens (Human) - TBC1D13 gene Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. Indicus|evm.model.CM009501.1.805 P38447 NUCG_BOVIN 100.000 0.993333 1.00334 ENDOG - Endonuclease G, mitochondrial precursor - Bos taurus (Bovine) - ENDOG gene Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. Indicus|evm.model.CM009501.1.806 Q5T280 CI114_HUMAN 94.385 0.98939 1.00266 SPOUT1 - Putative methyltransferase C9orf114 - Homo sapiens (Human) - SPOUT1 gene Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325). Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (PubMed:28431233). Indicus|evm.model.CM009501.1.807 Q16773 KAT1_HUMAN 86.998 0.917391 1.09005 KYAT1 - Kynurenine--oxoglutarate transaminase 1 - Homo sapiens (Human) - KYAT1 gene Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19338303, PubMed:28097769). Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites (PubMed:7883047). Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047). Indicus|evm.model.CM009501.1.809 Q8IWT6 LRC8A_HUMAN 99.012 0.997534 1.00123 LRRC8A - Volume-regulated anion channel subunit LRRC8A - Homo sapiens (Human) - LRRC8A gene Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:29769723, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24725410, PubMed:30095067, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:33171122). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (PubMed:33171122). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Can form functional channels by itself (in vitro) (PubMed:26824658). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746). Also required for T-cell development (By similarity). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:31270356, PubMed:33139539). Indicus|evm.model.CM009501.1.810 Q0IIB1 PHYD1_BOVIN 99.656 0.993151 1.00344 PHYHD1 - Phytanoyl-CoA dioxygenase domain-containing protein 1 - Bos taurus (Bovine) - PHYHD1 gene Has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA (By similarity). Indicus|evm.model.CM009501.1.811 Q58CR4 DOLK_BOVIN 100.000 0.996289 1.00186 DOLK - Dolichol kinase - Bos taurus (Bovine) - DOLK gene Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. Indicus|evm.model.CM009501.1.812 Q5SRE5 NU188_HUMAN 96.117 0.998858 1.00172 NUP188 - Nucleoporin NUP188 - Homo sapiens (Human) - NUP188 gene Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). Indicus|evm.model.CM009501.1.813 Q08DK5 SHLB2_BOVIN 98.942 0.959288 0.994937 SH3GLB2 - Endophilin-B2 - Bos taurus (Bovine) - SH3GLB2 gene Indicus|evm.model.CM009501.1.814 Q1JPG0 MIGA2_BOVIN 100.000 0.996633 1.00169 MIGA2 - Mitoguardin 2 - Bos taurus (Bovine) - MIGA2 gene Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. Indicus|evm.model.CM009501.1.815 B0KWE9 DOPP1_CALJA 95.798 0.991632 1.0042 DOLPP1 - Dolichyldiphosphatase 1 - Callithrix jacchus (White-tufted-ear marmoset) - DOLPP1 gene Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity). Indicus|evm.model.CM009501.1.816 P43155 CACP_HUMAN 92.492 0.99681 1.0016 CRAT - Carnitine O-acetyltransferase - Homo sapiens (Human) - CRAT gene Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation (PubMed:15099582, PubMed:29395073). Responsible for the synthesis of short- and branched-chain acylcarnitines (PubMed:23485643). Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates (PubMed:23485643). Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates (PubMed:23485643). Indicus|evm.model.CM009501.1.818 Q2KJ44 PTPA_BOVIN 100.000 0.993846 1.00309 PTPA - Serine/threonine-protein phosphatase 2A activator - Bos taurus (Bovine) - PTPA gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A (By similarity). Indicus|evm.model.CM009501.1.819 Q5PQP0 IER5L_RAT 99.074 0.413127 0.633252 Ier5l - Immediate early response gene 5-like protein - Rattus norvegicus (Rat) - Ier5l gene Indicus|evm.model.CM009501.1.821 Q5SZB4 CI050_HUMAN 52.860 0.968109 1.01856 C9orf50 - Uncharacterized protein C9orf50 - Homo sapiens (Human) - C9orf50 gene Indicus|evm.model.CM009501.1.822 Q2T9N3 NTM1A_BOVIN 99.552 0.991071 1.00448 NTMT1 - N-terminal Xaa-Pro-Lys N-methyltransferase 1 - Bos taurus (Bovine) - NTMT1 gene Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. Indicus|evm.model.CM009501.1.823 Q9NWX5 ASB6_HUMAN 94.537 0.995261 1.00238 ASB6 - Ankyrin repeat and SOCS box protein 6 - Homo sapiens (Human) - ASB6 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009501.1.824 Q99811 PRRX2_HUMAN 97.468 0.862637 0.719368 PRRX2 - Paired mesoderm homeobox protein 2 - Homo sapiens (Human) - PRRX2 gene May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development. Indicus|evm.model.CM009501.1.825 Q95L14 PTGES_BOVIN 100.000 0.987013 1.00654 PTGES - Prostaglandin E synthase - Bos taurus (Bovine) - PTGES gene Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity). Indicus|evm.model.CM009501.1.827 O14657 TOR1B_HUMAN 94.444 0.95053 0.842262 TOR1B - Torsin-1B precursor - Homo sapiens (Human) - TOR1B gene May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. Indicus|evm.model.CM009501.1.828 Q60HG2 TOR1A_MACFA 93.417 0.952096 1.00602 TOR1A - Torsin-1A precursor - Macaca fascicularis (Crab-eating macaque) - TOR1A gene Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues (By similarity). Indicus|evm.model.CM009501.1.829 Q9NZ63 TLS1_HUMAN 98.616 0.993103 1.00346 C9orf78 - Telomere length and silencing protein 1 homolog - Homo sapiens (Human) - C9orf78 gene Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Indicus|evm.model.CM009501.1.830 A1A4P5 PFD2_BOVIN 70.861 0.815217 1.19481 PFDN2 - Prefoldin subunit 2 - Bos taurus (Bovine) - PFDN2 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Indicus|evm.model.CM009501.1.831 A7Z056 UBP20_BOVIN 100.000 0.997809 1.0011 USP20 - Ubiquitin carboxyl-terminal hydrolase 20 - Bos taurus (Bovine) - USP20 gene Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Indicus|evm.model.CM009501.1.832 Q96RU3 FNBP1_HUMAN 93.750 0.966292 1.00972 FNBP1 - Formin-binding protein 1 - Homo sapiens (Human) - FNBP1 gene May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. Indicus|evm.model.CM009501.1.833 Q8BUV8 GP107_MOUSE 83.842 0.996409 1.01089 Gpr107 - Protein GPR107 precursor - Mus musculus (Mouse) - Gpr107 gene Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). Indicus|evm.model.CM009501.1.835 P62168 NCS1_RAT 92.432 0.929293 1.04211 Ncs1 - Neuronal calcium sensor 1 - Rattus norvegicus (Rat) - Ncs1 gene Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel. Indicus|evm.model.CM009501.1.836 Q8NDA2 HMCN2_HUMAN 83.064 0.99921 1.00079 HMCN2 - Hemicentin-2 precursor - Homo sapiens (Human) - HMCN2 gene collagen-containing extracellular matrix, extracellular matrix, extracellular space Indicus|evm.model.CM009501.1.837 P14568 ASSY_BOVIN 100.000 0.995157 1.00243 ASS1 - Argininosuccinate synthase - Bos taurus (Bovine) - ASS1 gene One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. Indicus|evm.model.CM009501.1.838 Q96I24 FUBP3_HUMAN 94.991 0.996429 0.979021 FUBP3 - Far upstream element-binding protein 3 - Homo sapiens (Human) - FUBP3 gene May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Indicus|evm.model.CM009501.1.840 A2AJ77 PRD12_MOUSE 98.944 0.962585 0.805479 Prdm12 - PR domain zinc finger protein 12 - Mus musculus (Mouse) - Prdm12 gene Involved in the positive regulation of histone H3-K9 dimethylation. Indicus|evm.model.CM009501.1.841 Q2KID0 EXOS2_BOVIN 99.659 0.993197 1.00341 EXOSC2 - Exosome complex component RRP4 - Bos taurus (Bovine) - EXOSC2 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7 (By similarity). Indicus|evm.model.CM009501.1.842 P10447 ABL_FSVHY 98.861 0.380208 2.62415 ABL - Tyrosine-protein kinase transforming protein Abl - Feline sarcoma virus (strain Hardy-Zuckerman 2) - ABL gene Indicus|evm.model.CM009501.1.843 P83862 OX26_BOVIN 99.248 0.977778 1.00746 QRFP - Orexigenic neuropeptide QRFP precursor - Bos taurus (Bovine) - QRFP gene Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity). Indicus|evm.model.CM009501.1.844 Q8N539 FBCD1_HUMAN 92.408 0.995671 1.00217 FIBCD1 - Fibrinogen C domain-containing protein 1 - Homo sapiens (Human) - FIBCD1 gene Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components. Indicus|evm.model.CM009501.1.845 Q9Y6N6 LAMC3_HUMAN 86.180 0.964691 0.503492 LAMC3 - Laminin subunit gamma-3 precursor - Homo sapiens (Human) - LAMC3 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Indicus|evm.model.CM009501.1.846 Q9Y6N6 LAMC3_HUMAN 84.906 0.564171 0.23746 LAMC3 - Laminin subunit gamma-3 precursor - Homo sapiens (Human) - LAMC3 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Indicus|evm.model.CM009501.1.847 Q9BQI0 AIF1L_HUMAN 95.122 0.159895 5.08667 AIF1L - Allograft inflammatory factor 1-like - Homo sapiens (Human) - AIF1L gene Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function. Indicus|evm.model.CM009501.1.848 P35658 NU214_HUMAN 82.325 0.999043 1 NUP214 - Nuclear pore complex protein Nup214 - Homo sapiens (Human) - NUP214 gene Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). Indicus|evm.model.CM009501.1.849 Q8C552 FA78A_MOUSE 96.466 0.992958 1.00353 Fam78a - Protein FAM78A - Mus musculus (Mouse) - Fam78a gene Indicus|evm.model.CM009501.1.850 Q8NBV4 PLPP7_HUMAN 95.203 0.992647 1.00369 PLPP7 - Inactive phospholipid phosphatase 7 - Homo sapiens (Human) - PLPP7 gene Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity). Indicus|evm.model.CM009501.1.852 Q7TPM1 PRC2B_MOUSE 85.516 0.348138 1.5 Prrc2b - Protein PRRC2B - Mus musculus (Mouse) - Prrc2b gene cell differentiation, in utero embryonic development Indicus|evm.model.CM009501.1.854 Q8R2R1 POMT1_MOUSE 85.497 0.995868 0.97319 Pomt1 - Protein O-mannosyl-transferase 1 - Mus musculus (Mouse) - Pomt1 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins. Indicus|evm.model.CM009501.1.855 Q0P5A4 UCK1_BOVIN 100.000 0.992806 1.00361 UCK1 - Uridine-cytidine kinase 1 - Bos taurus (Bovine) - UCK1 gene Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor (By similarity). Indicus|evm.model.CM009501.1.856 A0A1B0GWB2 PRT1B_HUMAN 66.667 0.976654 0.977186 PRRT1B - Proline rich transmembrane protein 1B - Homo sapiens (Human) - PRRT1B gene membrane Indicus|evm.model.CM009501.1.857 Q13905 RPGF1_HUMAN 91.142 0.979391 1.03621 RAPGEF1 - Rap guanine nucleotide exchange factor 1 - Homo sapiens (Human) - RAPGEF1 gene Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. Indicus|evm.model.CM009501.1.858 Q2TBN7 MED27_BOVIN 100.000 0.99359 1.00322 MED27 - Mediator of RNA polymerase II transcription subunit 27 - Bos taurus (Bovine) - MED27 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009501.1.859 Q96CW9 NTNG2_HUMAN 89.617 0.968198 1.06792 NTNG2 - Netrin-G2 precursor - Homo sapiens (Human) - NTNG2 gene Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. Indicus|evm.model.CM009501.1.860 Q7Z333 SETX_HUMAN 76.586 0.991431 1.00261 SETX - Probable helicase senataxin - Homo sapiens (Human) - SETX gene Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). Indicus|evm.model.CM009501.1.861 Q15361 TTF1_HUMAN 72.037 0.687664 0.841989 TTF1 - Transcription termination factor 1 - Homo sapiens (Human) - TTF1 gene Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. Indicus|evm.model.CM009501.1.862 Q6ZQR2 CFA77_HUMAN 81.875 0.992982 0.890625 CFAP77 - Cilia- and flagella-associated protein 77 - Homo sapiens (Human) - CFAP77 gene Indicus|evm.model.CM009501.1.864 Q9BZE3 BARH1_HUMAN 94.667 0.773438 1.17431 BARHL1 - BarH-like 1 homeobox protein - Homo sapiens (Human) - BARHL1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009501.1.865 Q9H8H2 DDX31_HUMAN 78.962 0.994558 0.86369 DDX31 - Probable ATP-dependent RNA helicase DDX31 - Homo sapiens (Human) - DDX31 gene Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed:23019224). Indicus|evm.model.CM009501.1.866 Q9UKN8 TF3C4_HUMAN 92.457 0.997543 0.990268 GTF3C4 - General transcription factor 3C polypeptide 4 - Homo sapiens (Human) - GTF3C4 gene Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box. Indicus|evm.model.CM009501.1.867 Q96MA6 KAD8_HUMAN 82.255 0.957916 1.04175 AK8 - Adenylate kinase 8 - Homo sapiens (Human) - AK8 gene Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Indicus|evm.model.CM009501.1.868 Q96E40 SACA9_HUMAN 90.854 0.693617 1.05856 SPACA9 - Sperm acrosome-associated protein 9 - Homo sapiens (Human) - SPACA9 gene acrosomal vesicle, ciliary basal body, ciliary base, cytoplasmic microtubule, nucleus, sperm flagellum Indicus|evm.model.CM009501.1.869 Q92574 TSC1_HUMAN 88.069 0.998276 0.996564 TSC1 - Hamartin - Homo sapiens (Human) - TSC1 gene In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Seems not to be required for TSC2 GAP activity towards RHEB (PubMed:15340059). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). Indicus|evm.model.CM009501.1.870 Q5VTD9 GFI1B_HUMAN 89.426 0.993976 1.00606 GFI1B - Zinc finger protein Gfi-1b - Homo sapiens (Human) - GFI1B gene Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. Indicus|evm.model.CM009501.1.871 Q9Y5Q8 TF3C5_HUMAN 81.818 0.996283 1.03661 GTF3C5 - General transcription factor 3C polypeptide 5 - Homo sapiens (Human) - GTF3C5 gene Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. Indicus|evm.model.CM009501.1.872 P30122 CEL_BOVIN 99.488 0.975 1.00503 CEL - Bile salt-activated lipase precursor - Bos taurus (Bovine) - CEL gene Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA) (PubMed:10220579). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). Indicus|evm.model.CM009501.1.873 Q03386 GNDS_RAT 84.368 0.970838 0.919553 Ralgds - Ral guanine nucleotide dissociation stimulator - Rattus norvegicus (Rat) - Ralgds gene Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Indicus|evm.model.CM009501.1.874 Q95158 GBGT1_CANLF 81.844 0.994236 1 GBGT1 - Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 - Canis lupus familiaris (Dog) - GBGT1 gene Catalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer) (PubMed:8855242, PubMed:10506200). Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens such as E.coli uropathogenic strains (PubMed:10506200). Indicus|evm.model.CM009501.1.875 Q03386 GNDS_RAT 60.150 0.767606 0.158659 Ralgds - Ral guanine nucleotide dissociation stimulator - Rattus norvegicus (Rat) - Ralgds gene Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Indicus|evm.model.CM009501.1.877 P07380 LACB2_HORSE 66.412 0.214168 3.35359 LGB2 - Beta-lactoglobulin-2 precursor - Equus caballus (Horse) - LGB2 gene Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule. Indicus|evm.model.CM009501.1.878 P02754 LACB_BOVIN 100.000 0.988827 1.00562 LGB - Beta-lactoglobulin precursor - Bos taurus (Bovine) - LGB gene Primary component of whey, it binds retinol and is probably involved in the transport of that molecule. Indicus|evm.model.CM009501.1.880 Q2YDM8 GL6D1_BOVIN 99.675 0.993528 1.00325 GLT6D1 - Glycosyltransferase 6 domain-containing protein 1 - Bos taurus (Bovine) - GLT6D1 gene Indicus|evm.model.CM009501.1.881 Q8WX39 LCN9_HUMAN 46.821 0.585034 1.67045 LCN9 - Epididymal-specific lipocalin-9 precursor - Homo sapiens (Human) - LCN9 gene extracellular space Indicus|evm.model.CM009501.1.882 Q5JUK2 SOLH1_HUMAN 46.855 0.786744 1.05793 SOHLH1 - Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 - Homo sapiens (Human) - SOHLH1 gene Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity). Indicus|evm.model.CM009501.1.884 Q5JUK3 KCNT1_HUMAN 92.971 0.945325 1.02602 KCNT1 - Potassium channel subfamily T member 1 - Homo sapiens (Human) - KCNT1 gene Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). Indicus|evm.model.CM009501.1.886 Q5T5Y3 CAMP1_HUMAN 79.035 0.986266 0.954432 CAMSAP1 - Calmodulin-regulated spectrin-associated protein 1 - Homo sapiens (Human) - CAMSAP1 gene Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24486153, PubMed:24706919, PubMed:24117850). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). Indicus|evm.model.CM009501.1.887 Q9BSL1 UBAC1_HUMAN 87.407 0.995037 0.995062 UBAC1 - Ubiquitin-associated domain-containing protein 1 - Homo sapiens (Human) - UBAC1 gene Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. Indicus|evm.model.CM009501.1.888 Q96BF6 NACC2_HUMAN 97.115 0.152819 1.14821 NACC2 - Nucleus accumbens-associated protein 2 - Homo sapiens (Human) - NACC2 gene Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. Indicus|evm.model.CM009501.1.889 H0YL14 TM250_HUMAN 93.525 0.985714 1.00719 TMEM250 - Transmembrane protein 250 - Homo sapiens (Human) - TMEM250 gene May play a role in cell proliferation by promoting progression into S phase. Indicus|evm.model.CM009501.1.890 O97581 LHX3_PIG 95.979 0.920792 1.05483 LHX3 - LIM/homeobox protein Lhx3 - Sus scrofa (Pig) - LHX3 gene Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Indicus|evm.model.CM009501.1.891 Q6ZRP7 QSOX2_HUMAN 77.288 0.962357 0.875358 QSOX2 - Sulfhydryl oxidase 2 precursor - Homo sapiens (Human) - QSOX2 gene Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. Indicus|evm.model.CM009501.1.892 A0A096LP49 CC187_HUMAN 53.163 0.429795 1.97648 CCDC187 - Coiled-coil domain-containing protein 187 - Homo sapiens (Human) - CCDC187 gene Indicus|evm.model.CM009501.1.894 Q9R080 GPSM1_RAT 92.780 0.92068 1.04903 Gpsm1 - G-protein-signaling modulator 1 - Rattus norvegicus (Rat) - Gpsm1 gene Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Indicus|evm.model.CM009501.1.895 Q5SXM8 DNLZ_HUMAN 71.910 0.988235 0.955056 DNLZ - DNL-type zinc finger protein precursor - Homo sapiens (Human) - DNLZ gene May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation. Indicus|evm.model.CM009501.1.896 Q9H257 CARD9_HUMAN 80.112 0.990775 1.01119 CARD9 - Caspase recruitment domain-containing protein 9 - Homo sapiens (Human) - CARD9 gene Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors (PubMed:26961233, PubMed:33558980). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (PubMed:24231284, PubMed:25702837, PubMed:25057046, PubMed:26679537, PubMed:26961233, PubMed:26521038, PubMed:27777981, PubMed:29080677, PubMed:33558980). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (By similarity). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11053425, PubMed:26488816, PubMed:31296852, PubMed:26961233, PubMed:33558980). CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (PubMed:24231284). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (By similarity). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (PubMed:33548172). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (PubMed:33548172). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (By similarity). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (By similarity). Indicus|evm.model.CM009501.1.897 Q5SXM2 SNPC4_HUMAN 58.401 0.997732 0.900613 SNAPC4 - snRNA-activating protein complex subunit 4 - Homo sapiens (Human) - SNAPC4 gene Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. Indicus|evm.model.CM009501.1.898 Q2KJD6 ENTR1_BOVIN 99.702 0.893333 1.04457 ENTR1 - Endosome-associated-trafficking regulator 1 - Bos taurus (Bovine) - ENTR1 gene Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1. Plays a role in the formation of cilia. Involved in cargo protein localization, such as PKD2, at primary cilia (By similarity). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity). Indicus|evm.model.CM009501.1.899 Q0P5M8 MPPA_BOVIN 100.000 0.93985 1.01333 PMPCA - Mitochondrial-processing peptidase subunit alpha precursor - Bos taurus (Bovine) - PMPCA gene Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Indicus|evm.model.CM009501.1.900 Q9NRR6 INP5E_HUMAN 74.242 0.996956 1.02019 INPP5E - Phosphatidylinositol polyphosphate 5-phosphatase type IV precursor - Homo sapiens (Human) - INPP5E gene Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10764818) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). Indicus|evm.model.CM009501.1.901 O15027 SC16A_HUMAN 67.015 0.983932 1.00339 SEC16A - Protein transport protein Sec16A - Homo sapiens (Human) - SEC16A gene Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:17005010, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). Indicus|evm.model.CM009501.1.902 P46531 NOTC1_HUMAN 88.642 0.657407 1.01448 NOTCH1 - Neurogenic locus notch homolog protein 1 precursor - Homo sapiens (Human) - NOTCH1 gene Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Indicus|evm.model.CM009501.1.903 O15120 PLCB_HUMAN 74.368 0.989247 1.0036 AGPAT2 - 1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor - Homo sapiens (Human) - AGPAT2 gene Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Indicus|evm.model.CM009501.1.904 Q99ML4 DIK1B_MOUSE 79.903 0.907489 1.05336 Dipk1b - Divergent protein kinase domain 1B - Mus musculus (Mouse) - Dipk1b gene Indicus|evm.model.CM009501.1.906 Q3SYR7 RL9_BOVIN 98.958 0.989637 1.00521 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009501.1.908 Q8CFC4 BGAT2_RAT 72.917 0.753968 1.13174 Abo2 - Histo-blood group ABO system transferase 2 - Rattus norvegicus (Rat) - Abo2 gene Posseses strong B transferase activity and a weak A transferase activity. Indicus|evm.model.CM009501.1.909 Q0VCY3 SURF6_BOVIN 100.000 0.99435 1.00283 SURF6 - Surfeit locus protein 6 - Bos taurus (Bovine) - SURF6 gene Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). Indicus|evm.model.CM009501.1.910 Q5E9K2 MED22_BOVIN 100.000 0.990099 1.00498 MED22 - Mediator of RNA polymerase II transcription subunit 22 - Bos taurus (Bovine) - MED22 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009501.1.911 Q2TBQ5 RL7A_BOVIN 100.000 0.992509 1.00376 RPL7A - 60S ribosomal protein L7a - Bos taurus (Bovine) - RPL7A gene cytosolic large ribosomal subunit, RNA binding, maturation of LSU-rRNA Indicus|evm.model.CM009501.1.912 Q15526 SURF1_HUMAN 86.770 0.941176 0.906667 SURF1 - Surfeit locus protein 1 - Homo sapiens (Human) - SURF1 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Indicus|evm.model.CM009501.1.913 Q15527 SURF2_HUMAN 77.992 0.992278 1.01172 SURF2 - Surfeit locus protein 2 - Homo sapiens (Human) - SURF2 gene nuclear speck, nucleolus, nucleoplasm, plasma membrane Indicus|evm.model.CM009501.1.914 A7YY49 SURF4_BOVIN 99.606 0.875433 1.07435 SURF4 - Surfeit locus protein 4 - Bos taurus (Bovine) - SURF4 gene May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Indicus|evm.model.CM009501.1.915 Q8NE28 STKL1_HUMAN 67.231 0.922967 1.03088 STKLD1 - Serine/threonine kinase-like domain-containing protein STKLD1 - Homo sapiens (Human) - STKLD1 gene protein serine/threonine kinase activity Indicus|evm.model.CM009501.1.916 Q9GZR2 REXO4_HUMAN 64.252 0.995134 0.973934 REXO4 - RNA exonuclease 4 - Homo sapiens (Human) - REXO4 gene nuclear speck, nucleolus, nucleoplasm, nucleus, 3'-5' exonuclease activity, double-stranded DNA binding, endonuclease activity, exonuclease activity, RNA binding, single-stranded DNA binding Indicus|evm.model.CM009501.1.917 Q76LX8 ATS13_HUMAN 67.265 0.994448 1.00981 ADAMTS13 - A disintegrin and metalloproteinase with thrombospondin motifs 13 precursor - Homo sapiens (Human) - ADAMTS13 gene Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. Indicus|evm.model.CM009501.1.918 Q8BG21 FLOWR_MOUSE 88.961 0.884393 1.0117 Cacfd1 - Calcium channel flower homolog - Mus musculus (Mouse) - Cacfd1 gene vesicle-mediated transport Indicus|evm.model.CM009501.1.919 Q9UGQ3 GTR6_HUMAN 87.574 0.996063 1.00197 SLC2A6 - Solute carrier family 2, facilitated glucose transporter member 6 - Homo sapiens (Human) - SLC2A6 gene Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose (PubMed:30431159). Indicus|evm.model.CM009501.1.921 A6NI61 MYMK_HUMAN 91.403 0.990991 1.00452 MYMK - Protein myomaker - Homo sapiens (Human) - MYMK gene Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:28681861). Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX. Acts independently of MYMX (By similarity). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (By similarity). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers (By similarity). Indicus|evm.model.CM009501.1.922 Q86TH1 ATL2_HUMAN 89.529 0.997908 1.00526 ADAMTSL2 - ADAMTS-like protein 2 precursor - Homo sapiens (Human) - ADAMTSL2 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization, negative regulation of transforming growth factor beta receptor signaling pathway Indicus|evm.model.CM009501.1.923 Q8BUM6 F163B_MOUSE 87.425 0.98773 0.976048 Fam163b - Protein FAM163B - Mus musculus (Mouse) - Fam163b gene Indicus|evm.model.CM009501.1.924 P15101 DOPO_BOVIN 98.689 0.996727 1.00164 DBH - Dopamine beta-hydroxylase - Bos taurus (Bovine) - DBH gene Conversion of dopamine to noradrenaline. Indicus|evm.model.CM009501.1.925 Q9UL12 SARDH_HUMAN 87.378 0.997826 1.00218 SARDH - Sarcosine dehydrogenase, mitochondrial precursor - Homo sapiens (Human) - SARDH gene cytoplasm, mitochondrial matrix, mitochondrion, oxidoreductase activity, sarcosine dehydrogenase activity, choline catabolic process, sarcosine catabolic process Indicus|evm.model.CM009501.1.926 Q60992 VAV2_MOUSE 92.902 0.992574 0.930876 Vav2 - Guanine nucleotide exchange factor VAV2 - Mus musculus (Mouse) - Vav2 gene Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Indicus|evm.model.CM009501.1.927 Q9R0C8 VAV3_MOUSE 72.222 0.144628 0.285714 Vav3 - Guanine nucleotide exchange factor VAV3 - Mus musculus (Mouse) - Vav3 gene Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion. Indicus|evm.model.CM009501.1.929 A0A1B0GUI7 BRDOS_HUMAN 92.857 0.976471 1.0119 BRD3OS - Putative uncharacterized protein BRD3OS - Homo sapiens (Human) - BRD3OS gene Indicus|evm.model.CM009501.1.930 Q15059 BRD3_HUMAN 92.450 0.964039 0.995868 BRD3 - Bromodomain-containing protein 3 - Homo sapiens (Human) - BRD3 gene Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Indicus|evm.model.CM009501.1.932 Q498M4 WDR5_RAT 98.089 0.907246 1.03293 Wdr5 - WD repeat-containing protein 5 - Rattus norvegicus (Rat) - Wdr5 gene Contributes to histone modification (By similarity). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity). Indicus|evm.model.CM009501.1.938 D6RBM5 U17LN_HUMAN 60.440 0.523256 0.939891 USP17L23 - Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23 - Homo sapiens (Human) - USP17L23 gene Indicus|evm.model.CM009501.1.939 Q00975 CAC1B_HUMAN 91.187 0.615524 0.941855 CACNA1B - Voltage-dependent N-type calcium channel subunit alpha-1B - Homo sapiens (Human) - CACNA1B gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Indicus|evm.model.CM009501.1.940 Q9H9B1 EHMT1_HUMAN 85.703 0.994565 0.992296 EHMT1 - Histone-lysine N-methyltransferase EHMT1 - Homo sapiens (Human) - EHMT1 gene Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). Indicus|evm.model.CM009501.1.942 Q8N5I2 ARRD1_HUMAN 86.650 0.969925 0.921478 ARRDC1 - Arrestin domain-containing protein 1 - Homo sapiens (Human) - ARRDC1 gene Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). Indicus|evm.model.CM009501.1.943 Q7TSV3 ZMY19_RAT 94.787 0.985915 0.938326 Zmynd19 - Zinc finger MYND domain-containing protein 19 - Rattus norvegicus (Rat) - Zmynd19 gene May be involved as a regulatory molecule in GPR24/MCH-R1 signaling. Indicus|evm.model.CM009501.1.944 Q9BTV6 DPH7_HUMAN 64.615 0.746269 1.33407 DPH7 - Diphthine methyltransferase - Homo sapiens (Human) - DPH7 gene Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Indicus|evm.model.CM009501.1.945 Q5BJX1 RM41_RAT 77.778 0.985294 1.01493 Mrpl41 - 39S ribosomal protein L41, mitochondrial precursor - Rattus norvegicus (Rat) - Mrpl41 gene Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. Indicus|evm.model.CM009501.1.946 Q6ZV29 PLPL7_HUMAN 82.181 0.980363 1.00532 PNPLA7 - Patatin-like phospholipase domain-containing protein 7 - Homo sapiens (Human) - PNPLA7 gene Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0). Indicus|evm.model.CM009501.1.947 Q6X4W1 NSMF_HUMAN 94.400 0.954111 0.986792 NSMF - NMDA receptor synaptonuclear signaling and neuronal migration factor - Homo sapiens (Human) - NSMF gene Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. Indicus|evm.model.CM009501.1.949 A0JND9 ENTP8_BOVIN 99.394 0.995968 1.00202 ENTPD8 - Ectonucleoside triphosphate diphosphohydrolase 8 - Bos taurus (Bovine) - ENTPD8 gene Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP (By similarity). Indicus|evm.model.CM009501.1.950 Q86UR1 NOXA1_HUMAN 64.375 0.993617 0.987395 NOXA1 - NADPH oxidase activator 1 - Homo sapiens (Human) - NOXA1 gene Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. Indicus|evm.model.CM009501.1.951 Q8N9H8 MUT7_HUMAN 61.286 0.713519 1.06393 EXD3 - Exonuclease mut-7 homolog - Homo sapiens (Human) - EXD3 gene Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity). Indicus|evm.model.CM009501.1.952 Q8N9H8 MUT7_HUMAN 63.704 0.881579 0.173516 EXD3 - Exonuclease mut-7 homolog - Homo sapiens (Human) - EXD3 gene Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity). Indicus|evm.model.CM009501.1.953 Q91ZA8 NRARP_MOUSE 97.436 0.974684 0.692982 Nrarp - Notch-regulated ankyrin repeat-containing protein - Mus musculus (Mouse) - Nrarp gene Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (By similarity). Involved in the regulation of canonical Wnt signaling by stabilizing LEF1 (By similarity). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (PubMed:21795391, PubMed:21998026). Indicus|evm.model.CM009501.1.954 Q9NXH8 TOR4A_HUMAN 85.882 0.206388 0.962175 TOR4A - Torsin-4A - Homo sapiens (Human) - TOR4A gene endoplasmic reticulum lumen, extracellular region, nuclear envelope, platelet alpha granule lumen, ATPase activity, platelet degranulation Indicus|evm.model.CM009501.1.955 Q8WX92 NELFB_HUMAN 87.204 0.947526 1.15 NELFB - Negative elongation factor B - Homo sapiens (Human) - NELFB gene Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity). Indicus|evm.model.CM009501.1.956 A2RSX4 STPG3_MOUSE 74.699 0.931818 0.287582 Stpg3 - Protein STPG3 - Mus musculus (Mouse) - Stpg3 gene cytoskeleton Indicus|evm.model.CM009501.1.957 Q4QR77 F166A_RAT 81.308 0.993769 1 Fam166a - Protein FAM166A - Rattus norvegicus (Rat) - Fam166a gene ciliary basal body Indicus|evm.model.CM009501.1.958 P68372 TBB4B_MOUSE 100.000 0.995516 1.00225 Tubb4b - Tubulin beta-4B chain - Mus musculus (Mouse) - Tubb4b gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009501.1.959 Q8N130 NPT2C_HUMAN 79.221 0.288679 0.884808 SLC34A3 - Sodium-dependent phosphate transport protein 2C - Homo sapiens (Human) - SLC34A3 gene May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx. Indicus|evm.model.CM009501.1.960 P0DH78 RN224_HUMAN 71.739 0.73262 1.19872 RNF224 - RING finger protein 224 - Homo sapiens (Human) - RNF224 gene Indicus|evm.model.CM009501.1.961 A0JNN6 CRTP1_BOVIN 92.424 0.984962 1.05556 CYSRT1 - Cysteine-rich tail protein 1 - Bos taurus (Bovine) - CYSRT1 gene Indicus|evm.model.CM009501.1.962 Q8K0W3 RN208_MOUSE 89.850 0.992509 1.00755 Rnf208 - RING finger protein 208 - Mus musculus (Mouse) - Rnf208 gene cytosol, nucleoplasm, ubiquitin-protein transferase activity, protein autoubiquitination Indicus|evm.model.CM009501.1.963 Q1JPJ0 NDOR1_BOVIN 99.492 0.76 1.29816 NDOR1 - NADPH-dependent diflavin oxidoreductase 1 - Bos taurus (Bovine) - NDOR1 gene Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. Indicus|evm.model.CM009501.1.964 Q8R235 TM203_MOUSE 99.254 0.184211 5.30882 Tmem203 - Transmembrane protein 203 - Mus musculus (Mouse) - Tmem203 gene Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873). Indicus|evm.model.CM009501.1.965 Q5E9C3 SSNA1_BOVIN 100.000 0.13369 6.28571 SSNA1 - Sjoegren syndrome nuclear autoantigen 1 homolog - Bos taurus (Bovine) - SSNA1 gene centrosome, ciliary basal body Indicus|evm.model.CM009501.1.966 Q9UJX6 ANC2_HUMAN 91.935 0.592233 0.125304 ANAPC2 - Anaphase-promoting complex subunit 2 - Homo sapiens (Human) - ANAPC2 gene Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. Indicus|evm.model.CM009501.1.967 Q9D2F0 TM210_MOUSE 74.615 0.895833 0.979592 Tmem210 - Transmembrane protein 210 precursor - Mus musculus (Mouse) - Tmem210 gene Indicus|evm.model.CM009501.1.968 Q2I0M4 LRC26_HUMAN 76.241 0.851064 0.98503 LRRC26 - Leucine-rich repeat-containing protein 26 precursor - Homo sapiens (Human) - LRRC26 gene Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium. Indicus|evm.model.CM009501.1.969 Q05586 NMDZ1_HUMAN 96.802 0.997819 0.977612 GRIN1 - Glutamate receptor ionotropic, NMDA 1 precursor - Homo sapiens (Human) - GRIN1 gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761). Indicus|evm.model.CM009501.1.971 P19793 RXRA_HUMAN 100.000 0.287004 1.19913 RXRA - Retinoic acid receptor RXR-alpha - Homo sapiens (Human) - RXRA gene Receptor for retinoic acid that acts as a transcription factor (PubMed:11162439, PubMed:11915042). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:28167758, PubMed:17761950, PubMed:16107141, PubMed:18800767, PubMed:19167885). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632). Indicus|evm.model.CM009501.1.973 Q9UKM7 MA1B1_HUMAN 73.667 0.968903 0.874106 MAN1B1 - Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase - Homo sapiens (Human) - MAN1B1 gene Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). Indicus|evm.model.CM009501.1.974 Q9UKM7 MA1B1_HUMAN 63.492 0.382716 0.23176 MAN1B1 - Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase - Homo sapiens (Human) - MAN1B1 gene Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). Indicus|evm.model.CM009501.1.975 Q3KQV9 UAP1L_HUMAN 84.327 0.89505 0.996055 UAP1L1 - UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 - Homo sapiens (Human) - UAP1L1 gene UDP-N-acetylglucosamine diphosphorylase activity, UDP-N-acetylglucosamine biosynthetic process Indicus|evm.model.CM009501.1.976 Q86UD0 SAPC2_HUMAN 88.764 0.249275 0.875635 SAPCD2 - Suppressor APC domain-containing protein 2 - Homo sapiens (Human) - SAPCD2 gene Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). Indicus|evm.model.CM009501.1.977 Q9Y5L3 ENTP2_HUMAN 86.869 0.995968 1.00202 ENTPD2 - Ectonucleoside triphosphate diphosphohydrolase 2 - Homo sapiens (Human) - ENTPD2 gene In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP. Indicus|evm.model.CM009501.1.978 Q9NQX5 NPDC1_HUMAN 67.925 0.578755 0.84 NPDC1 - Neural proliferation differentiation and control protein 1 precursor - Homo sapiens (Human) - NPDC1 gene Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity). Indicus|evm.model.CM009501.1.979 G3MZR2 FUT7_BOVIN 98.264 0.944079 0.888889 FUT7 - Alpha-(1,3)-fucosyltransferase 7 - Bos taurus (Bovine) - FUT7 gene Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates in the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization (PubMed:22909383). In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and both di-fucosylated and trifucosylated structures from mono-fucosylated precursors. However does not catalyze alpha 1-3 fucosylation when an internal alpha 1-3 fucosylation is present in polylactosamine chain and the fucosylation rate of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc. Also catalyzes the transfer of a fucose from GDP-beta-fucose to the 6-sulfated a(2,3)sialylated substrate to produce 6-sulfo sLex mediating significant L-selectin-dependent cell adhesion. Through sialyl-Lewis(x) biosynthesis, can control SELE- and SELP-mediated cell adhesion with leukocytes and allows leukocytes tethering and rolling along the endothelial tissue thereby enabling the leukocytes to accumulate at a site of inflammation. May enhance embryo implantation through sialyl Lewis X (sLeX)-mediated adhesion of embryo cells to endometrium. May affect insulin signaling by upregulating the phosphorylation and expression of some signaling molecules involved in the insulin-signaling pathway through SLe(x) which is present on the glycans of the INSRR alpha subunit (By similarity). Indicus|evm.model.CM009501.1.980 P41234 ABCA2_MOUSE 96.369 0.170895 0.858258 Abca2 - ATP-binding cassette sub-family A member 2 - Mus musculus (Mouse) - Abca2 gene Probable lipid tranporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed:17488728, PubMed:22748276). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (By similarity). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926). May play a role in myelin formation (PubMed:17060448). Indicus|evm.model.CM009501.1.981 Q9BZC7 ABCA2_HUMAN 93.548 0.987179 0.0640657 ABCA2 - ATP-binding cassette sub-family A member 2 - Homo sapiens (Human) - ABCA2 gene Probable lipid tranporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed:15238223, PubMed:21810484, PubMed:24201375) (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). Indicus|evm.model.CM009501.1.982 O95833 CLIC3_HUMAN 78.059 0.990291 0.872881 CLIC3 - Chloride intracellular channel protein 3 - Homo sapiens (Human) - CLIC3 gene Can insert into membranes and form chloride ion channels. May participate in cellular growth control. Indicus|evm.model.CM009501.1.983 Q9BUH6 PAXX_HUMAN 87.000 0.970732 1.0049 PAXX - Protein PAXX - Homo sapiens (Human) - PAXX gene Involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks in DNA. May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery. Indicus|evm.model.CM009501.1.984 Q6ZST4 LCNL1_HUMAN 67.961 0.554348 1.12195 LCNL1 - Lipocalin-like 1 protein - Homo sapiens (Human) - LCNL1 gene Indicus|evm.model.CM009501.1.985 O02853 PTGDS_BOVIN 99.476 0.989583 1.00524 PTGDS - Prostaglandin-H2 D-isomerase precursor - Bos taurus (Bovine) - PTGDS gene Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed:9510973). Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). Indicus|evm.model.CM009501.1.986 Q6JVE5 LCN12_HUMAN 52.778 0.561129 1.66146 LCN12 - Epididymal-specific lipocalin-12 precursor - Homo sapiens (Human) - LCN12 gene Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity). Indicus|evm.model.CM009501.1.987 P07360 CO8G_HUMAN 80.693 0.990148 1.00495 C8G - Complement component C8 gamma chain precursor - Homo sapiens (Human) - C8G gene C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Indicus|evm.model.CM009501.1.989 Q969U6 FBXW5_HUMAN 90.265 0.9947 1 FBXW5 - F-box/WD repeat-containing protein 5 - Homo sapiens (Human) - FBXW5 gene Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Indicus|evm.model.CM009501.1.990 Q12933 TRAF2_HUMAN 86.047 0.996132 1.03194 TRAF2 - TNF receptor-associated factor 2 - Homo sapiens (Human) - TRAF2 gene Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. Indicus|evm.model.CM009501.1.991 O60869 EDF1_HUMAN 87.838 0.984733 0.885135 EDF1 - Endothelial differentiation-related factor 1 - Homo sapiens (Human) - EDF1 gene Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. Indicus|evm.model.CM009501.1.992 Q6UXC1 AEGP_HUMAN 75.882 0.997527 0.997533 MAMDC4 - Apical endosomal glycoprotein precursor - Homo sapiens (Human) - MAMDC4 gene Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. Indicus|evm.model.CM009501.1.993 Q32PA4 PHP14_BOVIN 99.200 0.984127 1.008 PHPT1 - 14 kDa phosphohistidine phosphatase - Bos taurus (Bovine) - PHPT1 gene Exhibits phosphohistidine phosphatase activity. Indicus|evm.model.CM009501.1.994 C9J069 AJM1_HUMAN 90.000 0.408974 0.79918 AJM1 - Apical junction component 1 homolog - Homo sapiens (Human) - AJM1 gene May be involved in the control of adherens junction integrity. Indicus|evm.model.CM009501.1.995 Q08DA0 RABL6_BOVIN 99.144 0.997151 1.00143 RABL6 - Rab-like protein 6 - Bos taurus (Bovine) - RABL6 gene May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A (By similarity). Indicus|evm.model.CM009501.1.997 A2AJB1 CC183_MOUSE 78.394 0.975701 1.00187 Ccdc183 - Coiled-coil domain-containing protein 183 - Mus musculus (Mouse) - Ccdc183 gene Indicus|evm.model.CM009501.1.998 Q3SZU9 TM141_BOVIN 100.000 0.981651 1.00926 TMEM141 - Transmembrane protein 141 - Bos taurus (Bovine) - TMEM141 gene Indicus|evm.model.CM009501.1.999 Q6UWW0 LCN15_HUMAN 76.879 0.291525 3.20652 LCN15 - Lipocalin-15 precursor - Homo sapiens (Human) - LCN15 gene Indicus|evm.model.CM009501.1.1000 P62502 LCN6_HUMAN 64.238 0.810811 1.13497 LCN6 - Epididymal-specific lipocalin-6 precursor - Homo sapiens (Human) - LCN6 gene May play a role in male fertility. Indicus|evm.model.CM009501.1.1001 Q810Z1 LCN10_MOUSE 55.114 0.94086 1.02198 Lcn10 - Epididymal-specific lipocalin-10 precursor - Mus musculus (Mouse) - Lcn10 gene May play a role in male fertility. May act as a retinoid carrier protein within the epididymis. Indicus|evm.model.CM009501.1.1002 P53715 LCN1_PIG 58.282 0.931034 0.988636 LCN1 - Lipocalin-1 precursor - Sus scrofa (Pig) - LCN1 gene Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket (By similarity). Indicus|evm.model.CM009501.1.1004 P82923 RT02_BOVIN 89.273 0.976271 1.00683 MRPS2 - 28S ribosomal protein S2, mitochondrial - Bos taurus (Bovine) - MRPS2 gene Required for mitoribosome formation and stability, and mitochondrial translation. Indicus|evm.model.CM009501.1.1005 Q32P67 CI116_BOVIN 100.000 0.985401 1.00735 UPF0691 protein C9orf116 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009501.1.1006 Q5T8A7 PPR26_HUMAN 52.122 0.992334 0.97105 PPP1R26 - Protein phosphatase 1 regulatory subunit 26 - Homo sapiens (Human) - PPP1R26 gene Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation. Indicus|evm.model.CM009501.1.1011 Q62609 NOE1_RAT 97.941 0.951965 0.94433 Olfm1 - Noelin precursor - Rattus norvegicus (Rat) - Olfm1 gene Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity). Indicus|evm.model.CM009501.1.1012 Q5I2E5 FCN2_BOVIN 99.088 0.993939 1.00304 FCN2 - Ficolin-2 precursor - Bos taurus (Bovine) - FCN2 gene May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity). Indicus|evm.model.CM009501.1.1014 P20908 CO5A1_HUMAN 96.146 0.649308 0.825354 COL5A1 - Collagen alpha-1(V) chain precursor - Homo sapiens (Human) - COL5A1 gene Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Indicus|evm.model.CM009501.1.1015 P20908 CO5A1_HUMAN 92.670 0.631229 0.163765 COL5A1 - Collagen alpha-1(V) chain precursor - Homo sapiens (Human) - COL5A1 gene Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Indicus|evm.model.CM009501.1.1020 Q9CQW9 IFM3_MOUSE 64.130 0.554878 1.19708 Ifitm3 - Interferon-induced transmembrane protein 3 - Mus musculus (Mouse) - Ifitm3 gene IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33270927). Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation. IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome. Exerts opposing activities on SARS-CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane. Indicus|evm.model.CM009501.1.1022 Q8TD33 SG1C1_HUMAN 77.895 0.979167 1.01053 SCGB1C1 - Secretoglobin family 1C member 1 precursor - Homo sapiens (Human) - SCGB1C1 gene Indicus|evm.model.CM009501.1.1023 Q2TBH0 ODF3A_BOVIN 99.606 0.992157 1.00394 ODF3 - Outer dense fiber protein 3 - Bos taurus (Bovine) - ODF3 gene Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail. Indicus|evm.model.CM009501.1.1024 Q3MHP8 BET1L_BOVIN 99.099 0.982143 1.00901 BET1L - BET1-like protein - Bos taurus (Bovine) - BET1L gene Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity). Indicus|evm.model.CM009501.1.1025 Q5E9J8 RIC8A_BOVIN 100.000 0.996234 1.00189 RIC8A - Synembryn-A - Bos taurus (Bovine) - RIC8A gene Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity). Indicus|evm.model.CM009501.1.1026 Q9NTG7 SIR3_HUMAN 82.857 0.661137 1.05764 SIRT3 - NAD-dependent protein deacetylase sirtuin-3, mitochondrial precursor - Homo sapiens (Human) - SIRT3 gene NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity). Indicus|evm.model.CM009501.1.1027 A6NNB3 IFM5_HUMAN 88.060 0.985185 1.02273 IFITM5 - Interferon-induced transmembrane protein 5 - Homo sapiens (Human) - IFITM5 gene Required for normal bone mineralization. Indicus|evm.model.CM009501.1.1028 Q32M88 PGGHG_HUMAN 77.068 0.463534 1.93487 PGGHG - Protein-glucosylgalactosylhydroxylysine glucosidase - Homo sapiens (Human) - PGGHG gene Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. Indicus|evm.model.CM009501.1.1029 P10175 COX8B_BOVIN 98.571 0.971831 1.01429 COX8B - Cytochrome c oxidase subunit 8B, mitochondrial precursor - Bos taurus (Bovine) - COX8B gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009501.1.1030 Q5E964 PSD13_BOVIN 100.000 0.944079 0.808511 PSMD13 - 26S proteasome non-ATPase regulatory subunit 13 - Bos taurus (Bovine) - PSMD13 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Indicus|evm.model.CM009501.1.1031 P13164 IFM1_HUMAN 75.000 0.526786 0.896 IFITM1 - Interferon-induced transmembrane protein 1 - Homo sapiens (Human) - IFITM1 gene IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). Indicus|evm.model.CM009502.1.1 Q8N6Y1 PCD20_HUMAN 90.441 0.997899 1.00105 PCDH20 - Protocadherin-20 precursor - Homo sapiens (Human) - PCDH20 gene Potential calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009502.1.2 P68105 EF1A1_RABIT 94.156 0.993363 0.978355 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009502.1.3 P84335 TPM1_CHEAU 80.714 0.640553 0.764085 Tropomyosin alpha-1 chain - Chelon auratus (Golden grey mullet) Indicus|evm.model.CM009502.1.4 Q2HJG4 TDRD3_BOVIN 96.712 0.997264 1.01247 TDRD3 - Tudor domain-containing protein 3 - Bos taurus (Bovine) - TDRD3 gene Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins (By similarity). Indicus|evm.model.CM009502.1.5 Q14694 UBP10_HUMAN 56.674 0.652591 0.652882 USP10 - Ubiquitin carboxyl-terminal hydrolase 10 - Homo sapiens (Human) - USP10 gene Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Indicus|evm.model.CM009502.1.6 P39872 RL3_BOVIN 71.264 0.934783 0.228288 RPL3 - 60S ribosomal protein L3 - Bos taurus (Bovine) - RPL3 gene The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Indicus|evm.model.CM009502.1.7 Q9NSV4 DIAP3_HUMAN 86.888 0.485395 0.975692 DIAPH3 - Protein diaphanous homolog 3 - Homo sapiens (Human) - DIAPH3 gene Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. Indicus|evm.model.CM009502.1.8 Q588U8 CFDP2_TRAJA 51.765 0.204545 0.689895 CFDP2 - Craniofacial development protein 2 - Tragulus javanicus (Lesser Malay chevrotain) - CFDP2 gene Indicus|evm.model.CM009502.1.9 Q3ZBP8 CO040_BOVIN 88.158 0.862069 0.690476 UPF0235 protein C15orf40 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009502.1.10 O14917 PCD17_HUMAN 98.105 0.998279 1.00259 PCDH17 - Protocadherin-17 precursor - Homo sapiens (Human) - PCDH17 gene Potential calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009502.1.11 Q86W50 MET16_HUMAN 75.000 0.980769 0.0925267 METTL16 - RNA N6-adenosine-methyltransferase METTL16 - Homo sapiens (Human) - METTL16 gene RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). Indicus|evm.model.CM009502.1.12 Q920A7 AFG31_MOUSE 71.512 0.981928 0.210393 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Indicus|evm.model.CM009502.1.13 P0DP42 T225B_HUMAN 72.637 0.913242 0.99095 TMEM225B - Transmembrane protein 225B - Homo sapiens (Human) - TMEM225B gene Indicus|evm.model.CM009502.1.14 Q9ER69 FL2D_MOUSE 88.889 0.989848 0.497475 Wtap - Pre-mRNA-splicing regulator WTAP - Mus musculus (Mouse) - Wtap gene Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (PubMed:29547716). Required for accumulation of METTL3 and METTL14 to nuclear speckle (By similarity). Acts as a mRNA splicing regulator (By similarity). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (By similarity). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (By similarity). Indicus|evm.model.CM009502.1.15 Q9ER69 FL2D_MOUSE 96.800 0.873239 0.358586 Wtap - Pre-mRNA-splicing regulator WTAP - Mus musculus (Mouse) - Wtap gene Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (PubMed:29547716). Required for accumulation of METTL3 and METTL14 to nuclear speckle (By similarity). Acts as a mRNA splicing regulator (By similarity). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (By similarity). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (By similarity). Indicus|evm.model.CM009502.1.19 O95206 PCDH8_HUMAN 72.535 0.729651 0.642991 PCDH8 - Protocadherin-8 precursor - Homo sapiens (Human) - PCDH8 gene Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). Indicus|evm.model.CM009502.1.20 Q6UX06 OLFM4_HUMAN 77.878 0.876248 0.982353 OLFM4 - Olfactomedin-4 precursor - Homo sapiens (Human) - OLFM4 gene May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. Indicus|evm.model.CM009502.1.21 O95206 PCDH8_HUMAN 94.030 0.998133 1.00093 PCDH8 - Protocadherin-8 precursor - Homo sapiens (Human) - PCDH8 gene Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). Indicus|evm.model.CM009502.1.22 P17404 CNMD_BOVIN 100.000 0.92011 1.08358 CNMD - Leukocyte cell-derived chemotaxin 1 precursor - Bos taurus (Bovine) - CNMD gene Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity). Indicus|evm.model.CM009502.1.23 Q2KIK0 SGT1_BOVIN 99.704 0.994083 1 SUGT1 - Protein SGT1 homolog - Bos taurus (Bovine) - SUGT1 gene May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009502.1.24 A0JN51 ELF1_BOVIN 100.000 0.996748 1.00163 ELF1 - ETS-related transcription factor Elf-1 - Bos taurus (Bovine) - ELF1 gene Transcription factor that activates the LYN and BLK promoters. Indicus|evm.model.CM009502.1.25 O75554 WBP4_HUMAN 79.088 0.965969 1.01596 WBP4 - WW domain-binding protein 4 - Homo sapiens (Human) - WBP4 gene Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:9724750, PubMed:19592703, PubMed:28781166). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). Indicus|evm.model.CM009502.1.26 Q86V97 KBTB6_HUMAN 85.390 0.997167 1.04748 KBTBD6 - Kelch repeat and BTB domain-containing protein 6 - Homo sapiens (Human) - KBTBD6 gene As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205). Indicus|evm.model.CM009502.1.28 Q8WVZ9 KBTB7_HUMAN 95.906 0.997063 0.995614 KBTBD7 - Kelch repeat and BTB domain-containing protein 7 - Homo sapiens (Human) - KBTBD7 gene As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205). Indicus|evm.model.CM009502.1.29 Q3MHI7 RF1M_BOVIN 100.000 0.995536 1.00224 MTRF1 - Peptide chain release factor 1, mitochondrial precursor - Bos taurus (Bovine) - MTRF1 gene Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA. Indicus|evm.model.CM009502.1.30 Q6N069 NAA16_HUMAN 93.048 0.996528 1 NAA16 - N-alpha-acetyltransferase 16, NatA auxiliary subunit - Homo sapiens (Human) - NAA16 gene Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Indicus|evm.model.CM009502.1.31 Q9Z2P4 RGCC_RAT 90.909 0.703226 1.13139 Rgcc - Regulator of cell cycle RGCC - Rattus norvegicus (Rat) - Rgcc gene Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation (By similarity). Indicus|evm.model.CM009502.1.33 A3KMH1 VWA8_HUMAN 89.338 0.884106 0.15853 VWA8 - von Willebrand factor A domain-containing protein 8 precursor - Homo sapiens (Human) - VWA8 gene Exhibits ATPase activity in vitro. Indicus|evm.model.CM009502.1.34 Q86XP1 DGKH_HUMAN 94.834 0.923867 0.958197 DGKH - Diacylglycerol kinase eta - Homo sapiens (Human) - DGKH gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). Indicus|evm.model.CM009502.1.35 Q9UKA4 AKA11_HUMAN 78.796 0.998951 1.00263 AKAP11 - A-kinase anchor protein 11 - Homo sapiens (Human) - AKAP11 gene Binds to type II regulatory subunits of protein kinase A and anchors/targets them. Indicus|evm.model.CM009502.1.36 O14788 TNF11_HUMAN 83.929 0.982143 0.176656 TNFSF11 - Tumor necrosis factor ligand superfamily member 11 - Homo sapiens (Human) - TNFSF11 gene Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity). Indicus|evm.model.CM009502.1.38 O14788 TNF11_HUMAN 91.534 0.964103 0.615142 TNFSF11 - Tumor necrosis factor ligand superfamily member 11 - Homo sapiens (Human) - TNFSF11 gene Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity). Indicus|evm.model.CM009502.1.39 Q17QP0 F216B_BOVIN 100.000 0.8 1.24138 FAM216B - Protein FAM216B - Bos taurus (Bovine) - FAM216B gene Indicus|evm.model.CM009502.1.40 Q96J88 ESIP1_HUMAN 67.089 0.986885 0.959119 EPSTI1 - Epithelial-stromal interaction protein 1 - Homo sapiens (Human) - EPSTI1 gene Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity). Indicus|evm.model.CM009502.1.41 Q9Y5T4 DJC15_HUMAN 80.667 0.986667 1 DNAJC15 - DnaJ homolog subfamily C member 15 - Homo sapiens (Human) - DNAJC15 gene Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. Indicus|evm.model.CM009502.1.42 Q8TC92 ENOX1_HUMAN 99.109 0.996441 0.874028 ENOX1 - Ecto-NOX disulfide-thiol exchanger 1 - Homo sapiens (Human) - ENOX1 gene Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock. Indicus|evm.model.CM009502.1.44 Q5T0U0 CC122_HUMAN 68.727 0.991525 0.864469 CCDC122 - Coiled-coil domain-containing protein 122 - Homo sapiens (Human) - CCDC122 gene Indicus|evm.model.CM009502.1.45 Q8IV20 LACC1_HUMAN 85.116 0.995316 0.993023 LACC1 - Purine nucleoside phosphorylase LACC1 - Homo sapiens (Human) - LACC1 gene Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (PubMed:31978345). Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed:31978345). Also has adenosine deaminase activity (PubMed:31978345). Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:31978345). Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface (PubMed:31978345). The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345). Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (PubMed:28593945, PubMed:31875558). Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (PubMed:31875558). Does not show laccase activity (PubMed:27959965, PubMed:31978345). Indicus|evm.model.CM009502.1.46 Q9EQ60 CAC1H_RAT 58.696 0.514793 0.0716405 Cacna1h - Voltage-dependent T-type calcium channel subunit alpha-1H - Rattus norvegicus (Rat) - Cacna1h gene Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:11073957). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (By similarity). Indicus|evm.model.CM009502.1.47 Q6TAW2 SERP2_MOUSE 98.113 0.339869 2.35385 Serp2 - Stress-associated endoplasmic reticulum protein 2 - Mus musculus (Mouse) - Serp2 gene May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential). Indicus|evm.model.CM009502.1.48 Q4R4H5 T22D1_MACFA 100.000 0.986207 1.00694 TSC22D1 - TSC22 domain family protein 1 - Macaca fascicularis (Crab-eating macaque) - TSC22D1 gene Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (By similarity). Indicus|evm.model.CM009502.1.49 Q5R4H1 T22D1_PONAB 80.996 0.996904 0.905607 TSC22D1 - TSC22 domain family protein 1 - Pongo abelii (Sumatran orangutan) - TSC22D1 gene Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (By similarity). Indicus|evm.model.CM009502.1.51 Q9UHK0 NUFP1_HUMAN 76.768 0.993915 0.99596 NUFIP1 - Nuclear fragile X mental retardation-interacting protein 1 - Homo sapiens (Human) - NUFIP1 gene Binds RNA. Indicus|evm.model.CM009502.1.52 Q3ZBM6 GPAM1_BOVIN 100.000 0.623077 1.40794 GPALPP1 - GPALPP motifs-containing protein 1 - Bos taurus (Bovine) - GPALPP1 gene Indicus|evm.model.CM009502.1.53 Q3SYV4 CAP1_BOVIN 84.648 0.995074 0.860169 CAP1 - Adenylyl cyclase-associated protein 1 - Bos taurus (Bovine) - CAP1 gene Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. Indicus|evm.model.CM009502.1.54 Q2T9L9 T2FB_BOVIN 89.744 0.70303 0.662651 GTF2F2 - General transcription factor IIF subunit 2 - Bos taurus (Bovine) - GTF2F2 gene TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity (By similarity). Indicus|evm.model.CM009502.1.55 A6H6X4 KCTD4_BOVIN 99.614 0.992308 1.00386 KCTD4 - BTB/POZ domain-containing protein KCTD4 - Bos taurus (Bovine) - KCTD4 gene Indicus|evm.model.CM009502.1.56 Q2T9L9 T2FB_BOVIN 100.000 0.838028 0.570281 GTF2F2 - General transcription factor IIF subunit 2 - Bos taurus (Bovine) - GTF2F2 gene TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity (By similarity). Indicus|evm.model.CM009502.1.57 Q5E984 TCTP_BOVIN 100.000 0.777273 1.27907 TPT1 - Translationally-controlled tumor protein - Bos taurus (Bovine) - TPT1 gene Involved in calcium binding and microtubule stabilization. Indicus|evm.model.CM009502.1.58 Q8HXE3 KMCP1_MACFA 95.533 0.826211 1.20619 SLC25A30 - Kidney mitochondrial carrier protein 1 - Macaca fascicularis (Crab-eating macaque) - SLC25A30 gene Probable transporter. Indicus|evm.model.CM009502.1.59 Q96JB2 COG3_HUMAN 91.411 0.978049 0.990338 COG3 - Conserved oligomeric Golgi complex subunit 3 - Homo sapiens (Human) - COG3 gene Involved in ER-Golgi transport. Indicus|evm.model.CM009502.1.60 Q5W0A0 ERI6B_HUMAN 52.535 0.817391 0.826149 ERICH6B - Glutamate-rich protein 6B - Homo sapiens (Human) - ERICH6B gene Indicus|evm.model.CM009502.1.61 A6QQS3 CBY2_BOVIN 99.780 0.995614 1.0022 CBY2 - Protein chibby homolog 2 - Bos taurus (Bovine) - CBY2 gene Indicus|evm.model.CM009502.1.62 Q8IW03 SIAH3_HUMAN 71.809 0.728346 0.944238 SIAH3 - Seven in absentia homolog 3 - Homo sapiens (Human) - SIAH3 gene Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria. Indicus|evm.model.CM009502.1.63 Q5T200 ZC3HD_HUMAN 95.552 0.393829 0.991007 ZC3H13 - Zinc finger CCCH domain-containing protein 13 - Homo sapiens (Human) - ZC3H13 gene Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). Indicus|evm.model.CM009502.1.65 Q2KIG3 CBPB2_BOVIN 99.764 0.995283 1.00236 CPB2 - Carboxypeptidase B2 precursor - Bos taurus (Bovine) - CPB2 gene Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. Indicus|evm.model.CM009502.1.66 Q61233 PLSL_MOUSE 96.332 0.996815 1.00159 Lcp1 - Plastin-2 - Mus musculus (Mouse) - Lcp1 gene Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Indicus|evm.model.CM009502.1.67 Q05C16 LRC63_HUMAN 60.000 0.729447 1.15345 LRRC63 - Leucine-rich repeat-containing protein 63 - Homo sapiens (Human) - LRRC63 gene Indicus|evm.model.CM009502.1.68 A7E316 PACER_BOVIN 99.849 0.996988 1.00151 RUBCNL - Protein associated with UVRAG as autophagy enhancer - Bos taurus (Bovine) - RUBCNL gene Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (By similarity). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (By similarity). Indicus|evm.model.CM009502.1.69 Q9Y2L9 LRCH1_HUMAN 85.516 0.993856 0.894231 LRCH1 - Leucine-rich repeat and calponin homology domain-containing protein 1 - Homo sapiens (Human) - LRCH1 gene Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. Indicus|evm.model.CM009502.1.70 Q08E20 ESTD_BOVIN 100.000 0.992933 1.00355 ESD - S-formylglutathione hydrolase - Bos taurus (Bovine) - ESD gene Serine hydrolase involved in the detoxification of formaldehyde. Indicus|evm.model.CM009502.1.71 Q75Z89 5HT2A_BOVIN 100.000 0.995754 1.00213 HTR2A - 5-hydroxytryptamine receptor 2A - Bos taurus (Bovine) - HTR2A gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity). Indicus|evm.model.CM009502.1.72 Q148D5 SUCB1_BOVIN 99.784 0.99569 1.00216 SUCLA2 - Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial precursor - Bos taurus (Bovine) - SUCLA2 gene ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Indicus|evm.model.CM009502.1.73 Q9NV35 NUD15_HUMAN 93.902 0.947674 1.04878 NUDT15 - Nucleotide triphosphate diphosphatase NUDT15 - Homo sapiens (Human) - NUDT15 gene May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956). Indicus|evm.model.CM009502.1.74 Q3SYZ9 MED4_BOVIN 100.000 0.99262 1.0037 MED4 - Mediator of RNA polymerase II transcription subunit 4 - Bos taurus (Bovine) - MED4 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009502.1.75 A5A6H4 ROA1_PANTR 95.238 0.639456 0.91875 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Indicus|evm.model.CM009502.1.76 Q3T0P7 ITM2B_BOVIN 99.624 0.992509 1.00376 ITM2B - Integral membrane protein 2B - Bos taurus (Bovine) - ITM2B gene Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity). Indicus|evm.model.CM009502.1.77 P62919 RL8_RAT 96.109 0.992248 1.00389 Rpl8 - 60S ribosomal protein L8 - Rattus norvegicus (Rat) - Rpl8 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009502.1.78 P06400 RB_HUMAN 93.534 0.997847 1.00108 RB1 - Retinoblastoma-associated protein - Homo sapiens (Human) - RB1 gene Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). Indicus|evm.model.CM009502.1.79 Q5RCZ7 RCBT2_PONAB 96.097 0.824885 1.18149 RCBTB2 - RCC1 and BTB domain-containing protein 2 - Pongo abelii (Sumatran orangutan) - RCBTB2 gene Indicus|evm.model.CM009502.1.80 Q95N03 CLTR2_PIG 83.140 0.991329 1.0029 CYSLTR2 - Cysteinyl leukotriene receptor 2 - Sus scrofa (Pig) - CYSLTR2 gene Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). Indicus|evm.model.CM009502.1.81 Q62280 SSXT_MOUSE 59.259 0.622951 0.291866 Ss18 - Protein SSXT - Mus musculus (Mouse) - Ss18 gene Appears to function synergistically with RBM14 as a transcriptional coactivator. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Indicus|evm.model.CM009502.1.82 Q9Y2H6 FND3A_HUMAN 94.324 0.98681 1.01252 FNDC3A - Fibronectin type-III domain-containing protein 3A - Homo sapiens (Human) - FNDC3A gene Mediates spermatid-Sertoli adhesion during spermatogenesis. Indicus|evm.model.CM009502.1.83 O43193 MTLR_HUMAN 81.220 0.954762 1.01942 MLNR - Motilin receptor - Homo sapiens (Human) - MLNR gene Receptor for motilin. Indicus|evm.model.CM009502.1.84 Q4R683 CDAC1_MACFA 91.456 0.996124 1.00194 CDADC1 - Cytidine and dCMP deaminase domain-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - CDADC1 gene Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively. May play an important role in testicular development and spermatogenesis. Indicus|evm.model.CM009502.1.86 Q9H9S4 CB39L_HUMAN 95.536 0.943662 1.05341 CAB39L - Calcium-binding protein 39-like - Homo sapiens (Human) - CAB39L gene Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). Indicus|evm.model.CM009502.1.88 Q96T68 SETB2_HUMAN 77.469 0.997147 0.974965 SETDB2 - Histone-lysine N-methyltransferase SETDB2 - Homo sapiens (Human) - SETDB2 gene Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. Indicus|evm.model.CM009502.1.89 Q2HJ93 PHF11_BOVIN 100.000 0.994083 1.00297 PHF11 - PHD finger protein 11 - Bos taurus (Bovine) - PHF11 gene Positive regulator of Th1-type cytokine gene expression. Indicus|evm.model.CM009502.1.90 Q8NDN9 RCBT1_HUMAN 97.175 0.757143 1.31827 RCBTB1 - RCC1 and BTB domain-containing protein 1 - Homo sapiens (Human) - RCBTB1 gene May be involved in cell cycle regulation by chromatin remodeling. Indicus|evm.model.CM009502.1.91 Q0VCI6 PIHD1_BOVIN 96.429 0.847328 0.451724 PIH1D1 - PIH1 domain-containing protein 1 - Bos taurus (Bovine) - PIH1D1 gene Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity). Indicus|evm.model.CM009502.1.92 Q58DI9 ARL11_BOVIN 81.503 0.891192 1.06044 ARL11 - ADP-ribosylation factor-like protein 11 - Bos taurus (Bovine) - ARL11 gene May play a role in apoptosis. May act as a tumor suppressor (By similarity). Indicus|evm.model.CM009502.1.93 Q9BY08 EBPL_HUMAN 80.583 0.990338 1.00485 EBPL - Emopamil-binding protein-like - Homo sapiens (Human) - EBPL gene Does not possess sterol isomerase activity and does not bind sigma ligands. Indicus|evm.model.CM009502.1.94 O35344 IMA4_MOUSE 100.000 0.995984 0.955854 Kpna3 - Importin subunit alpha-4 - Mus musculus (Mouse) - Kpna3 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Indicus|evm.model.CM009502.1.95 Q2T9X3 SPRY7_BOVIN 100.000 0.989848 1.0051 SPRYD7 - SPRY domain-containing protein 7 - Bos taurus (Bovine) - SPRYD7 gene Indicus|evm.model.CM009502.1.96 Q32L60 TRI13_BOVIN 100.000 0.995098 1.00246 TRIM13 - E3 ubiquitin-protein ligase TRIM13 - Bos taurus (Bovine) - TRIM13 gene Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Plays also a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation. Participates as well in T-cell receptor-mediated NF-kappa-B activation. In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B. Indicus|evm.model.CM009502.1.97 Q863D4 KCNRG_BOVIN 100.000 0.992537 1.00375 KCNRG - Potassium channel regulatory protein - Bos taurus (Bovine) - KCNRG gene Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (By similarity). Indicus|evm.model.CM009502.1.98 Q3ZBI3 RNH2B_BOVIN 98.566 0.99278 0.89644 RNASEH2B - Ribonuclease H2 subunit B - Bos taurus (Bovine) - RNASEH2B gene Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). Indicus|evm.model.CM009502.1.99 O75343 GCYB2_HUMAN 82.095 0.819695 1.16856 GUCY1B2 - Guanylate cyclase soluble subunit beta-2 - Homo sapiens (Human) - GUCY1B2 gene cGMP-mediated signaling Indicus|evm.model.CM009502.1.100 A0A1B0GVH6 CM042_HUMAN 79.421 0.993443 0.938462 C13orf42 - Uncharacterized protein C13orf42 - Homo sapiens (Human) - C13orf42 gene Indicus|evm.model.CM009502.1.101 Q5RA50 F124A_PONAB 92.115 0.945392 0.53663 FAM124A - Protein FAM124A - Pongo abelii (Sumatran orangutan) - FAM124A gene Indicus|evm.model.CM009502.1.102 Q86V42 F124A_HUMAN 61.567 0.960289 0.507326 FAM124A - Protein FAM124A - Homo sapiens (Human) - FAM124A gene Indicus|evm.model.CM009502.1.103 A6QQ92 SERP3_BOVIN 99.225 0.761341 1.2675 SERPINE3 - Serpin E3 precursor - Bos taurus (Bovine) - SERPINE3 gene Probable serine protease inhibitor. Indicus|evm.model.CM009502.1.104 Q9UL03 INT6_HUMAN 95.265 0.99768 0.971815 INTS6 - Integrator complex subunit 6 - Homo sapiens (Human) - INTS6 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144). Indicus|evm.model.CM009502.1.105 Q96P53 WDFY2_HUMAN 98.250 0.995012 1.0025 WDFY2 - WD repeat and FYVE domain-containing protein 2 - Homo sapiens (Human) - WDFY2 gene Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553). Indicus|evm.model.CM009502.1.106 A6QP05 DHR12_BOVIN 100.000 0.993711 1.00315 DHRS12 - Dehydrogenase/reductase SDR family member 12 - Bos taurus (Bovine) - DHRS12 gene Putative oxidoreductase. Indicus|evm.model.CM009502.1.107 Q0II65 CCD70_BOVIN 99.550 0.991031 1.0045 CCDC70 - Coiled-coil domain-containing protein 70 precursor - Bos taurus (Bovine) - CCDC70 gene Indicus|evm.model.CM009502.1.108 Q9XT50 ATP7B_SHEEP 95.883 0.991003 0.960133 ATP7B - Copper-transporting ATPase 2 - Ovis aries (Sheep) - ATP7B gene Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. Indicus|evm.model.CM009502.1.110 Q2TAA5 ALG11_HUMAN 89.634 0.982 1.01626 ALG11 - GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase - Homo sapiens (Human) - ALG11 gene Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain. Indicus|evm.model.CM009502.1.111 Q7TSC3 NEK5_MOUSE 78.598 0.339623 1.26794 Nek5 - Serine/threonine-protein kinase Nek5 - Mus musculus (Mouse) - Nek5 gene protein kinase activity, positive regulation of cysteine-type endopeptidase activity, positive regulation of striated muscle cell differentiation Indicus|evm.model.CM009502.1.112 P51956 NEK3_HUMAN 84.158 0.993952 0.980237 NEK3 - Serine/threonine-protein kinase Nek3 - Homo sapiens (Human) - NEK3 gene Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. Indicus|evm.model.CM009502.1.113 A5D7U0 CKAP2_BOVIN 87.830 0.997072 1.0928 CKAP2 - Cytoskeleton-associated protein 2 - Bos taurus (Bovine) - CKAP2 gene Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). Indicus|evm.model.CM009502.1.114 A5PK00 VPS36_BOVIN 99.741 0.994832 1.00259 VPS36 - Vacuolar protein-sorting-associated protein 36 - Bos taurus (Bovine) - VPS36 gene Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. Indicus|evm.model.CM009502.1.115 Q5BIR3 THSD1_BOVIN 99.764 0.997647 1.00118 THSD1 - Thrombospondin type-1 domain-containing protein 1 precursor - Bos taurus (Bovine) - THSD1 gene Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. Indicus|evm.model.CM009502.1.116 Q6XPS3 TPTE2_HUMAN 63.450 0.787682 1.18199 TPTE2 - Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 - Homo sapiens (Human) - TPTE2 gene Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. Indicus|evm.model.CM009502.1.117 Q9Y619 ORNT1_HUMAN 95.349 0.993377 1.00332 SLC25A15 - Mitochondrial ornithine transporter 1 - Homo sapiens (Human) - SLC25A15 gene Ornithine-citrulline antiporter. Connects the cytosolic and the intramitochondrial reactions of the urea cycle by exchanging cytosolic ornithine with matrix citrulline (PubMed:12807890). The stoichiometry is close to 1:1 (By similarity). Indicus|evm.model.CM009502.1.118 Q86VY4 TSYL5_HUMAN 78.177 0.995169 0.992806 TSPYL5 - Testis-specific Y-encoded-like protein 5 - Homo sapiens (Human) - TSPYL5 gene Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. Indicus|evm.model.CM009502.1.119 P82925 RT31_BOVIN 99.482 0.994832 1.00259 MRPS31 - 28S ribosomal protein S31, mitochondrial precursor - Bos taurus (Bovine) - MRPS31 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit Indicus|evm.model.CM009502.1.120 E1BPQ1 FOXO1_BOVIN 100.000 0.995708 0.746795 FOXO1 - Forkhead box protein O1 - Bos taurus (Bovine) - FOXO1 gene Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Promotes neural cell death (By similarity). Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (By similarity). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). Indicus|evm.model.CM009502.1.123 Q3SZI7 COG6_BOVIN 99.848 0.99696 1.00152 COG6 - Conserved oligomeric Golgi complex subunit 6 - Bos taurus (Bovine) - COG6 gene Required for normal Golgi function. Indicus|evm.model.CM009502.1.124 Q9Y693 LHPL6_HUMAN 97.500 0.99005 1.005 LHFPL6 - LHFPL tetraspan subfamily member 6 protein precursor - Homo sapiens (Human) - LHFPL6 gene membrane Indicus|evm.model.CM009502.1.125 Q5JS37 NHLC3_HUMAN 82.997 0.891753 1.11816 NHLRC3 - NHL repeat-containing protein 3 precursor - Homo sapiens (Human) - NHLRC3 gene azurophil granule lumen, extracellular region, ubiquitin protein ligase activity, neutrophil degranulation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination Indicus|evm.model.CM009502.1.126 Q5PRE5 PRSR1_MOUSE 82.723 0.203352 0.980285 Proser1 - Proline and serine-rich protein 1 - Mus musculus (Mouse) - Proser1 gene Indicus|evm.model.CM009502.1.127 Q8TAV4 STML3_HUMAN 83.688 0.958478 0.993127 STOML3 - Stomatin-like protein 3 - Homo sapiens (Human) - STOML3 gene Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations. Indicus|evm.model.CM009502.1.128 Q5SZK8 FREM2_HUMAN 90.044 0.99937 1.00126 FREM2 - FRAS1-related extracellular matrix protein 2 precursor - Homo sapiens (Human) - FREM2 gene Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (PubMed:15838507). Required for epidermal adhesion (PubMed:15838507). Involved in the development of eyelids and the anterior segment of the eyeballs (PubMed:29688405, PubMed:30802441). Indicus|evm.model.CM009502.1.129 Q2KJG2 UFM1_BOVIN 100.000 0.621359 1.21176 UFM1 - Ubiquitin-fold modifier 1 precursor - Bos taurus (Bovine) - UFM1 gene Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription. Indicus|evm.model.CM009502.1.131 P79100 TRPC4_BOVIN 100.000 0.997959 1.00102 TRPC4 - Short transient receptor potential channel 4 - Bos taurus (Bovine) - TRPC4 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Acts as a cell-cell contact-dependent endothelial calcium entry channel (By similarity). Indicus|evm.model.CM009502.1.132 Q15063 POSTN_HUMAN 94.976 0.997611 1.0012 POSTN - Periostin precursor - Homo sapiens (Human) - POSTN gene Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Indicus|evm.model.CM009502.1.133 Q16254 E2F4_HUMAN 67.769 0.819549 0.322034 E2F4 - Transcription factor E2F4 - Homo sapiens (Human) - E2F4 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Indicus|evm.model.CM009502.1.134 Q8NEM7 SP20H_HUMAN 96.248 0.649573 1.05135 SUPT20H - Transcription factor SPT20 homolog - Homo sapiens (Human) - SUPT20H gene Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Indicus|evm.model.CM009502.1.135 Q2KHU3 EXOS8_BOVIN 99.638 0.99278 1.00362 EXOSC8 - Exosome complex component RRP43 - Bos taurus (Bovine) - EXOSC8 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs (By similarity). Indicus|evm.model.CM009502.1.136 Q9Y673 ALG5_HUMAN 92.901 0.993846 1.00309 ALG5 - Dolichyl-phosphate beta-glucosyltransferase - Homo sapiens (Human) - ALG5 gene endoplasmic reticulum membrane, membrane, oligosaccharyl transferase activity, protein glycosylation, protein N-linked glycosylation, protein N-linked glycosylation via asparagine Indicus|evm.model.CM009502.1.137 Q9JIW5 SMAD9_MOUSE 96.047 0.99536 1.00233 Smad9 - Mothers against decapentaplegic homolog 9 - Mus musculus (Mouse) - Smad9 gene Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation. Indicus|evm.model.CM009502.1.138 O00287 RFXAP_HUMAN 86.920 0.991597 0.875 RFXAP - Regulatory factor X-associated protein - Homo sapiens (Human) - RFXAP gene Part of the RFX complex that binds to the X-box of MHC II promoters. Indicus|evm.model.CM009502.1.139 A2A2V5 SRTM1_HUMAN 97.196 0.981481 1.00935 SERTM1 - Serine-rich and transmembrane domain-containing protein 1 - Homo sapiens (Human) - SERTM1 gene intracellular membrane-bounded organelle Indicus|evm.model.CM009502.1.140 Q6AY13 CCNA1_RAT 87.886 0.995261 1.00238 Ccna1 - Cyclin-A1 - Rattus norvegicus (Rat) - Ccna1 gene May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells (By similarity). Indicus|evm.model.CM009502.1.141 A0JNJ3 SPART_BOVIN 100.000 0.959712 1.04042 SPART - Spartin - Bos taurus (Bovine) - SPART gene May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. Indicus|evm.model.CM009502.1.142 Q29223 RL34_PIG 82.051 0.983051 1.00855 RPL34 - 60S ribosomal protein L34 - Sus scrofa (Pig) - RPL34 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009502.1.143 Q9NX45 SOLH2_HUMAN 72.066 0.995316 1.00471 SOHLH2 - Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 - Homo sapiens (Human) - SOHLH2 gene Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity). Indicus|evm.model.CM009502.1.144 O15075 DCLK1_HUMAN 99.595 0.997305 1.0027 DCLK1 - Serine/threonine-protein kinase DCLK1 - Homo sapiens (Human) - DCLK1 gene Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. Indicus|evm.model.CM009502.1.145 Q8NFP9 NBEA_HUMAN 98.849 0.998466 0.442634 NBEA - Neurobeachin - Homo sapiens (Human) - NBEA gene Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Indicus|evm.model.CM009502.1.146 Q8NFP9 NBEA_HUMAN 93.069 0.568182 0.059742 NBEA - Neurobeachin - Homo sapiens (Human) - NBEA gene Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Indicus|evm.model.CM009502.1.148 Q2TBV1 RFC3_BOVIN 100.000 0.994398 1.00281 RFC3 - Replication factor C subunit 3 - Bos taurus (Bovine) - RFC3 gene The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Indicus|evm.model.CM009502.1.149 Q9Y3M8 STA13_HUMAN 96.899 0.992248 0.115903 STARD13 - StAR-related lipid transfer protein 13 - Homo sapiens (Human) - STARD13 gene GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. Indicus|evm.model.CM009502.1.150 Q9UEF7 KLOT_HUMAN 89.765 0.979101 0.945652 KL - Klotho precursor - Homo sapiens (Human) - KL gene May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). Indicus|evm.model.CM009502.1.151 Q9NTI5 PDS5B_HUMAN 98.206 0.998621 1.00207 PDS5B - Sister chromatid cohesion protein PDS5 homolog B - Homo sapiens (Human) - PDS5B gene Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. Indicus|evm.model.CM009502.1.152 Q3T145 MDHC_BOVIN 89.809 0.787879 0.592814 MDH1 - Malate dehydrogenase, cytoplasmic - Bos taurus (Bovine) - MDH1 gene Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Indicus|evm.model.CM009502.1.153 Q92802 N42L2_HUMAN 74.912 0.472927 2.02744 N4BP2L2 - NEDD4-binding protein 2-like 2 - Homo sapiens (Human) - N4BP2L2 gene extracellular exosome, nucleus, transcription repressor complex, enzyme binding, transcription corepressor activity, negative regulation of hematopoietic stem cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of hematopoietic stem cell proliferation Indicus|evm.model.CM009502.1.154 Q29S05 N42L1_BOVIN 93.706 0.581967 1.4104 N4BP2L1 - NEDD4-binding protein 2-like 1 - Bos taurus (Bovine) - N4BP2L1 gene Indicus|evm.model.CM009502.1.155 Q864S8 BRCA2_FELCA 73.703 0.482356 1.0169 BRCA2 - Breast cancer type 2 susceptibility protein homolog - Felis catus (Cat) - BRCA2 gene Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity). Indicus|evm.model.CM009502.1.156 Q1XFL1 ZAR1L_BOVIN 99.631 0.778098 1.09119 ZAR1L - ZAR1-like protein - Bos taurus (Bovine) - ZAR1L gene cytoplasm, mRNA binding involved in posttranscriptional gene silencing, translation Indicus|evm.model.CM009502.1.157 Q5TBA9 FRY_HUMAN 97.887 0.971652 0.807833 FRY - Protein furry homolog - Homo sapiens (Human) - FRY gene Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. Indicus|evm.model.CM009502.1.158 Q5XM32 RXFP2_CANLF 89.688 0.99729 1.00136 RXFP2 - Relaxin receptor 2 - Canis lupus familiaris (Dog) - RXFP2 gene Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity). Indicus|evm.model.CM009502.1.159 Q3T139 R146B_BOVIN 98.980 0.989848 0.567723 RNF146B - E3 ubiquitin-protein ligase RNF146-B - Bos taurus (Bovine) - RNF146B gene E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity). Indicus|evm.model.CM009502.1.160 Q6Y288 B3GLT_HUMAN 88.206 0.995098 0.819277 B3GLCT - Beta-1,3-glucosyltransferase - Homo sapiens (Human) - B3GLCT gene O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. Indicus|evm.model.CM009502.1.161 Q6Y288 B3GLT_HUMAN 82.000 0.98 0.100402 B3GLCT - Beta-1,3-glucosyltransferase - Homo sapiens (Human) - B3GLCT gene O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. Indicus|evm.model.CM009502.1.162 Q0IIM3 HS105_BOVIN 99.651 0.997674 1.00116 HSPH1 - Heat shock protein 105 kDa - Bos taurus (Bovine) - HSPH1 gene Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. Indicus|evm.model.CM009502.1.164 Q8N6G2 TEX26_HUMAN 70.082 0.67507 1.23529 TEX26 - Testis-expressed protein 26 - Homo sapiens (Human) - TEX26 gene cytoplasm Indicus|evm.model.CM009502.1.165 A4IFN2 MEDAG_BOVIN 99.670 0.993421 1.0033 MEDAG - Mesenteric estrogen-dependent adipogenesis protein - Bos taurus (Bovine) - MEDAG gene Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes. Indicus|evm.model.CM009502.1.166 Q148F2 AL5AP_BOVIN 100.000 0.987654 1.00621 ALOX5AP - Arachidonate 5-lipoxygenase-activating protein - Bos taurus (Bovine) - ALOX5AP gene Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity). Indicus|evm.model.CM009502.1.167 Q5W0Q7 USPL1_HUMAN 70.467 0.997263 1.00366 USPL1 - SUMO-specific isopeptidase USPL1 - Homo sapiens (Human) - USPL1 gene SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). Indicus|evm.model.CM009502.1.168 P10103 HMGB1_BOVIN 100.000 0.990741 1.00465 HMGB1 - High mobility group protein B1 - Bos taurus (Bovine) - HMGB1 gene Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins (By similarity). Indicus|evm.model.CM009502.1.169 A9RA82 KATL1_PAPAN 97.551 0.995927 1.00204 KATNAL1 - Katanin p60 ATPase-containing subunit A-like 1 - Papio anubis (Olive baboon) - KATNAL1 gene Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (By similarity). Indicus|evm.model.CM009502.1.170 A8D8X1 RL10_SHEEP 76.562 0.984375 0.299065 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009502.1.172 O95164 UBL3_HUMAN 100.000 0.981651 0.931624 UBL3 - Ubiquitin-like protein 3 precursor - Homo sapiens (Human) - UBL3 gene extracellular exosome Indicus|evm.model.CM009502.1.173 P30825 SL7A1_HUMAN 91.256 0.996825 1.00159 SLC7A1 - High affinity cationic amino acid transporter 1 - Homo sapiens (Human) - SLC7A1 gene High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. Indicus|evm.model.CM009502.1.174 Q5JR59 MTUS2_HUMAN 70.703 0.998535 0.997078 MTUS2 - Microtubule-associated tumor suppressor candidate 2 - Homo sapiens (Human) - MTUS2 gene Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. Indicus|evm.model.CM009502.1.175 A5D7V7 S46A3_BOVIN 99.566 0.995671 1.00217 SLC46A3 - Solute carrier family 46 member 3 precursor - Bos taurus (Bovine) - SLC46A3 gene Indicus|evm.model.CM009502.1.176 Q3SZV5 POMP_BOVIN 100.000 0.985915 1.00709 POMP - Proteasome maturation protein - Bos taurus (Bovine) - POMP gene Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation (By similarity). Mediates the association of 20S preproteasome with the endoplasmic reticulum (By similarity). Indicus|evm.model.CM009502.1.178 P17948 VGFR1_HUMAN 81.343 0.954395 0.901345 FLT1 - Vascular endothelial growth factor receptor 1 precursor - Homo sapiens (Human) - FLT1 gene Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (Ref.11). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). Indicus|evm.model.CM009502.1.179 Q58A45 PAN3_HUMAN 95.401 0.921212 0.930101 PAN3 - PAN2-PAN3 deadenylation complex subunit PAN3 - Homo sapiens (Human) - PAN3 gene Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. Indicus|evm.model.CM009502.1.180 O15439 MRP4_HUMAN 88.333 0.226054 0.196981 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.181 F1M3J4 MRP4_RAT 71.564 0.945946 0.167547 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Indicus|evm.model.CM009502.1.182 P36888 FLT3_HUMAN 90.760 0.997949 0.981873 FLT3 - Receptor-type tyrosine-protein kinase FLT3 precursor - Homo sapiens (Human) - FLT3 gene Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. Indicus|evm.model.CM009502.1.183 A5PJD0 URAD_BOVIN 98.824 0.988304 1.00588 URAD - 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase - Bos taurus (Bovine) - URAD gene Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. Indicus|evm.model.CM009502.1.184 P18111 CDX1_MOUSE 94.030 0.47482 0.518657 Cdx1 - Homeobox protein CDX-1 - Mus musculus (Mouse) - Cdx1 gene Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA. Indicus|evm.model.CM009502.1.186 A1YF08 PDX1_GORGO 91.579 0.993007 1.00704 PDX1 - Pancreas/duodenum homeobox protein 1 - Gorilla gorilla gorilla (Western lowland gorilla) - PDX1 gene Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3' (By similarity). Indicus|evm.model.CM009502.1.187 Q9H4S2 GSX1_HUMAN 94.624 0.906404 0.768939 GSX1 - GS homeobox 1 - Homo sapiens (Human) - GSX1 gene Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development. Indicus|evm.model.CM009502.1.190 P0DPB5 RPC22_HUMAN 79.339 0.75817 1.2541 POLR1D - Protein POLR1D, isoform 2 - Homo sapiens (Human) - POLR1D gene cytosol, nucleoplasm, positive regulation of gene expression, epigenetic, positive regulation of type I interferon production, termination of RNA polymerase I transcription, transcription initiation from RNA polymerase I promoter Indicus|evm.model.CM009502.1.191 Q8N448 LNX2_HUMAN 88.261 0.997072 0.989855 LNX2 - Ligand of Numb protein X 2 - Homo sapiens (Human) - LNX2 gene Indicus|evm.model.CM009502.1.192 Q32KZ1 IF3M_BOVIN 99.634 0.931507 1.0696 MTIF3 - Translation initiation factor IF-3, mitochondrial precursor - Bos taurus (Bovine) - MTIF3 gene IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. Indicus|evm.model.CM009502.1.193 Q92664 TF3A_HUMAN 79.609 0.83848 1.15342 GTF3A - Transcription factor IIIA - Homo sapiens (Human) - GTF3A gene Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity). Indicus|evm.model.CM009502.1.194 Q6T310 RSLBA_HUMAN 88.511 0.975 0.991736 RASL11A - Ras-like protein family member 11A - Homo sapiens (Human) - RASL11A gene Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity). Indicus|evm.model.CM009502.1.195 A5JSS2 RL21_CAPHI 100.000 0.987578 1.00625 RPL21 - 60S ribosomal protein L21 - Capra hircus (Goat) - RPL21 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009502.1.196 A5D9H7 UBP12_BOVIN 99.718 0.876238 1.09485 USP12 - Ubiquitin carboxyl-terminal hydrolase 12 - Bos taurus (Bovine) - USP12 gene Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. Indicus|evm.model.CM009502.1.197 P47775 GPR12_HUMAN 93.114 0.99403 1.00299 GPR12 - G-protein coupled receptor 12 - Homo sapiens (Human) - GPR12 gene Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production. Indicus|evm.model.CM009502.1.198 Q9UPY6 WASF3_HUMAN 93.825 0.996016 1 WASF3 - Wiskott-Aldrich syndrome protein family member 3 - Homo sapiens (Human) - WASF3 gene Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Indicus|evm.model.CM009502.1.200 P49336 CDK8_HUMAN 99.525 0.9375 0.965517 CDK8 - Cyclin-dependent kinase 8 - Homo sapiens (Human) - CDK8 gene Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. Indicus|evm.model.CM009502.1.201 Q9Y252 RNF6_HUMAN 73.761 0.997015 0.978102 RNF6 - E3 ubiquitin-protein ligase RNF6 - Homo sapiens (Human) - RNF6 gene E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Indicus|evm.model.CM009502.1.202 C7EXK4 AT8A2_BOVIN 66.579 0.981966 0.966028 ATP8A2 - Phospholipid-transporting ATPase IB - Bos taurus (Bovine) - ATP8A2 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (PubMed:31371510). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. Indicus|evm.model.CM009502.1.204 A6QPA0 SHSA2_BOVIN 99.308 0.993103 1.00346 SHISA2 - Protein shisa-2 homolog precursor - Bos taurus (Bovine) - SHISA2 gene Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Indicus|evm.model.CM009502.1.205 C7EXK4 AT8A2_BOVIN 100.000 0.731343 0.466899 ATP8A2 - Phospholipid-transporting ATPase IB - Bos taurus (Bovine) - ATP8A2 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (PubMed:31371510). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. Indicus|evm.model.CM009502.1.206 C7EXK4 AT8A2_BOVIN 96.667 0.62766 0.0818815 ATP8A2 - Phospholipid-transporting ATPase IB - Bos taurus (Bovine) - ATP8A2 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (PubMed:31371510). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. Indicus|evm.model.CM009502.1.207 C7EXK4 AT8A2_BOVIN 99.206 0.812298 0.269164 ATP8A2 - Phospholipid-transporting ATPase IB - Bos taurus (Bovine) - ATP8A2 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (PubMed:31371510). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. Indicus|evm.model.CM009502.1.208 C7EXK4 AT8A2_BOVIN 100.000 0.90708 0.393728 ATP8A2 - Phospholipid-transporting ATPase IB - Bos taurus (Bovine) - ATP8A2 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (PubMed:31371510). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. Indicus|evm.model.CM009502.1.209 Q8R332 NUP58_MOUSE 91.312 0.996593 1 Nup58 - Nucleoporin p58/p45 - Mus musculus (Mouse) - Nup58 gene Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Indicus|evm.model.CM009502.1.210 Q9Y217 MTMR6_HUMAN 93.881 0.996785 1.00161 MTMR6 - Myotubularin-related protein 6 - Homo sapiens (Human) - MTMR6 gene Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598). Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). Indicus|evm.model.CM009502.1.211 Q8CCJ4 AMER2_MOUSE 78.947 0.741573 0.264881 Amer2 - APC membrane recruitment protein 2 - Mus musculus (Mouse) - Amer2 gene Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity). Indicus|evm.model.CM009502.1.213 Q5DU57 SPT13_MOUSE 82.595 0.493213 2.02134 Spata13 - Spermatogenesis-associated protein 13 - Mus musculus (Mouse) - Spata13 gene Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Indicus|evm.model.CM009502.1.214 Q0II24 C1QT9_BOVIN 99.700 0.994012 1.003 C1QTNF9 - Complement C1q and tumor necrosis factor-related protein 9 precursor - Bos taurus (Bovine) - C1QTNF9 gene Indicus|evm.model.CM009502.1.215 Q99797 MIPEP_HUMAN 87.079 0.995696 0.97756 MIPEP - Mitochondrial intermediate peptidase precursor - Homo sapiens (Human) - MIPEP gene Cleaves proteins, imported into the mitochondrion, to their mature size. Indicus|evm.model.CM009502.1.216 Q9NS68 TNR19_HUMAN 72.315 0.891026 1.10638 TNFRSF19 - Tumor necrosis factor receptor superfamily member 19 precursor - Homo sapiens (Human) - TNFRSF19 gene Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. Indicus|evm.model.CM009502.1.217 Q9NZJ4 SACS_HUMAN 90.647 0.999126 0.999345 SACS - Sacsin - Homo sapiens (Human) - SACS gene Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins. Indicus|evm.model.CM009502.1.218 Q0VCU7 SGCG_BOVIN 99.656 0.993151 1.00344 SGCG - Gamma-sarcoglycan - Bos taurus (Bovine) - SGCG gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Indicus|evm.model.CM009502.1.221 Q95L12 FGF9_PIG 61.272 0.666667 1.24038 FGF9 - Fibroblast growth factor 9 precursor - Sus scrofa (Pig) - FGF9 gene Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). Indicus|evm.model.CM009502.1.222 P31371 FGF9_HUMAN 98.925 0.92 0.480769 FGF9 - Fibroblast growth factor 9 precursor - Homo sapiens (Human) - FGF9 gene Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. Indicus|evm.model.CM009502.1.223 Q8IYU8 MICU2_HUMAN 84.296 0.99536 0.993088 MICU2 - Calcium uptake protein 2, mitochondrial precursor - Homo sapiens (Human) - MICU2 gene Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927). Indicus|evm.model.CM009502.1.224 Q0VC89 ZDH20_BOVIN 99.726 0.994536 1.00274 ZDHHC20 - Palmitoyltransferase ZDHHC20 - Bos taurus (Bovine) - ZDHHC20 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains. Indicus|evm.model.CM009502.1.225 Q3ZC04 RT63_BOVIN 100.000 0.980583 1.0098 MRPL57 - Ribosomal protein 63, mitochondrial - Bos taurus (Bovine) - MRPL57 gene mitochondrial inner membrane, mitochondrial ribosome, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009502.1.226 A8PUI7 SKA3_BOVIN 100.000 0.99505 1.00248 SKA3 - Spindle and kinetochore-associated protein 3 - Bos taurus (Bovine) - SKA3 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Indicus|evm.model.CM009502.1.228 Q3T022 SAP18_BOVIN 100.000 0.878613 1.13072 SAP18 - Histone deacetylase complex subunit SAP18 - Bos taurus (Bovine) - SAP18 gene Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function (By similarity). Indicus|evm.model.CM009502.1.229 Q9NRM7 LATS2_HUMAN 86.151 0.731836 0.695772 LATS2 - Serine/threonine-protein kinase LATS2 - Homo sapiens (Human) - LATS2 gene Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. Indicus|evm.model.CM009502.1.230 Q9C0E2 XPO4_HUMAN 94.296 0.998243 0.988705 XPO4 - Exportin-4 - Homo sapiens (Human) - XPO4 gene Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Indicus|evm.model.CM009502.1.232 Q17QF2 EFMT1_BOVIN 97.788 0.991189 1.00442 EEF1AKMT1 - EEF1A lysine methyltransferase 1 - Bos taurus (Bovine) - EEF1AKMT1 gene Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'. Indicus|evm.model.CM009502.1.233 Q8TAD2 IL17D_HUMAN 85.156 0.927007 0.678218 IL17D - Interleukin-17D precursor - Homo sapiens (Human) - IL17D gene Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells. Indicus|evm.model.CM009502.1.234 Q61371 IFT88_MOUSE 94.296 0.996368 1.00243 Ift88 - Intraflagellar transport protein 88 homolog - Mus musculus (Mouse) - Ift88 gene Involved in primary cilium biogenesis (PubMed:31761534, PubMed:11062270, PubMed:21289087). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. Indicus|evm.model.CM009502.1.235 Q8SPX7 CRYL1_BOVIN 100.000 0.993789 1.00312 CRYL1 - Lambda-crystallin homolog - Bos taurus (Bovine) - CRYL1 gene cytosol, L-gulonate 3-dehydrogenase activity, NAD+ binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Indicus|evm.model.CM009502.1.236 Q5E9Z5 CXB6_BOVIN 100.000 0.992366 1.00383 GJB6 - Gap junction beta-6 protein - Bos taurus (Bovine) - GJB6 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009502.1.237 A2VE67 CXB2_BOVIN 100.000 0.991189 1.00442 GJB2 - Gap junction beta-2 protein - Bos taurus (Bovine) - GJB2 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009502.1.239 P41987 CXA3_BOVIN 100.000 0.995098 1.00246 GJA3 - Gap junction alpha-3 protein - Bos taurus (Bovine) - GJA3 gene Structural component of lens fiber gap junctions (PubMed:8088962). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:8088962). Indicus|evm.model.CM009502.1.241 Q9UBW7 ZMYM2_HUMAN 94.190 0.940452 1.061 ZMYM2 - Zinc finger MYM-type protein 2 - Homo sapiens (Human) - ZMYM2 gene May function as a transcription factor. Indicus|evm.model.CM009502.1.244 A6QPH9 ZMYM5_BOVIN 99.851 0.997033 1.00149 ZMYM5 - Zinc finger MYM-type protein 5 - Bos taurus (Bovine) - ZMYM5 gene Functions as a transcriptional regulator. Indicus|evm.model.CM009502.1.245 Q1LZD9 PSPC1_BOVIN 96.154 0.996024 0.967308 PSPC1 - Paraspeckle component 1 - Bos taurus (Bovine) - PSPC1 gene Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009502.1.246 Q99549 MPP8_HUMAN 80.070 0.989498 0.996512 MPHOSPH8 - M-phase phosphoprotein 8 - Homo sapiens (Human) - MPHOSPH8 gene Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Indicus|evm.model.CM009502.1.247 E9PYK3 PARP4_MOUSE 73.856 0.692134 0.89741 Parp4 - Protein mono-ADP-ribosyltransferase PARP4 - Mus musculus (Mouse) - Parp4 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Indicus|evm.model.CM009502.1.249 Q5BQN8 CENPJ_PANTR 73.781 0.997786 1.01271 CENPJ - Centromere protein J - Pan troglodytes (Chimpanzee) - CENPJ gene Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (By similarity). Indicus|evm.model.CM009502.1.250 Q4R3G4 RNF17_MACFA 81.920 0.802663 1.07692 RNF17 - RING finger protein 17 - Macaca fascicularis (Crab-eating macaque) - RNF17 gene Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). Indicus|evm.model.CM009502.1.251 P54707 AT12A_HUMAN 87.317 0.958763 1.02695 ATP12A - Potassium-transporting ATPase alpha chain 2 - Homo sapiens (Human) - ATP12A gene The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (PubMed:9774385, PubMed:7485470, PubMed:8853415, PubMed:11341842). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (PubMed:29391451). Indicus|evm.model.CM009502.1.253 Q5BKY9 F133B_HUMAN 94.737 0.991935 1.00405 FAM133B - Protein FAM133B - Homo sapiens (Human) - FAM133B gene RNA binding Indicus|evm.model.CM009502.1.255 Q3T0D0 HNRPK_BOVIN 86.598 0.950495 0.217672 HNRNPK - Heterogeneous nuclear ribonucleoprotein K - Bos taurus (Bovine) - HNRNPK gene One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). Indicus|evm.model.CM009502.1.256 P28482 MK01_HUMAN 86.325 0.97479 0.330556 MAPK1 - Mitogen-activated protein kinase 1 - Homo sapiens (Human) - MAPK1 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). Indicus|evm.model.CM009502.1.259 Q9HC56 PCDH9_HUMAN 97.906 0.989583 0.155214 PCDH9 - Protocadherin-9 precursor - Homo sapiens (Human) - PCDH9 gene Potential calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009502.1.260 Q9HC56 PCDH9_HUMAN 99.704 0.987305 0.827809 PCDH9 - Protocadherin-9 precursor - Homo sapiens (Human) - PCDH9 gene Potential calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009502.1.261 Q9EQU5 SET_MOUSE 73.856 0.849162 0.619377 Set - Protein SET - Mus musculus (Mouse) - Set gene Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity). Indicus|evm.model.CM009502.1.262 P63170 DYL1_RAT 96.629 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Indicus|evm.model.CM009502.1.266 Q9NR64 KLHL1_HUMAN 86.628 0.777273 0.294118 KLHL1 - Kelch-like protein 1 - Homo sapiens (Human) - KLHL1 gene May play a role in organizing the actin cytoskeleton of the brain cells. Indicus|evm.model.CM009502.1.268 Q9QYB2 DACH1_MOUSE 100.000 0.944444 0.0958722 Dach1 - Dachshund homolog 1 - Mus musculus (Mouse) - Dach1 gene Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 (By similarity). Binds to chromatin DNA via its DACHbox-N domain. Indicus|evm.model.CM009502.1.270 Q08AG7 MZT1_HUMAN 95.082 0.594059 1.23171 MZT1 - Mitotic-spindle organizing protein 1 - Homo sapiens (Human) - MZT1 gene Required for gamma-tubulin complex recruitment to the centrosome. Indicus|evm.model.CM009502.1.271 Q6PGQ7 BORA_HUMAN 84.258 0.996429 1.00179 BORA - Protein aurora borealis - Homo sapiens (Human) - BORA gene Required for the activation of AURKA at the onset of mitosis. Indicus|evm.model.CM009502.1.272 Q9Y2L1 RRP44_HUMAN 88.830 0.987899 0.948852 DIS3 - Exosome complex exonuclease RRP44 - Homo sapiens (Human) - DIS3 gene Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. Indicus|evm.model.CM009502.1.273 Q8WXW3 PIBF1_HUMAN 89.432 0.997361 1.00132 PIBF1 - Progesterone-induced-blocking factor 1 - Homo sapiens (Human) - PIBF1 gene Plays a role in ciliogenesis. Indicus|evm.model.CM009502.1.274 Q13887 KLF5_HUMAN 84.464 0.995037 0.881838 KLF5 - Krueppel-like factor 5 - Homo sapiens (Human) - KLF5 gene Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. Indicus|evm.model.CM009502.1.275 Q9Y4X4 KLF12_HUMAN 99.005 0.995037 1.00249 KLF12 - Krueppel-like factor 12 - Homo sapiens (Human) - KLF12 gene Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Indicus|evm.model.CM009502.1.277 P09244 TBB7_CHICK 91.317 0.954424 0.84009 Tubulin beta-7 chain - Gallus gallus (Chicken) Indicus|evm.model.CM009502.1.278 O60343 TBCD4_HUMAN 91.153 0.9982 0.855932 TBC1D4 - TBC1 domain family member 4 - Homo sapiens (Human) - TBC1D4 gene May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. Indicus|evm.model.CM009502.1.279 O60343 TBCD4_HUMAN 91.018 0.599278 0.213405 TBC1D4 - TBC1 domain family member 4 - Homo sapiens (Human) - TBC1D4 gene May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. Indicus|evm.model.CM009502.1.280 Q2KIY0 COMD6_BOVIN 100.000 0.893617 1.10588 COMMD6 - COMM domain-containing protein 6 - Bos taurus (Bovine) - COMMD6 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Inhibits TNF-induced NFKB1 activation. Indicus|evm.model.CM009502.1.281 Q2TBG8 UCHL3_BOVIN 100.000 0.991342 1.00435 UCHL3 - Ubiquitin carboxyl-terminal hydrolase isozyme L3 - Bos taurus (Bovine) - UCHL3 gene Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3''. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome (By similarity). Indicus|evm.model.CM009502.1.282 Q6QMZ7 RL12_CHILA 80.282 0.752688 0.563636 RPL12 - 60S ribosomal protein L12 - Chinchilla lanigera (Long-tailed chinchilla) - RPL12 gene Binds directly to 26S ribosomal RNA. Indicus|evm.model.CM009502.1.283 Q8WWI1 LMO7_HUMAN 82.282 0.182941 1.05882 LMO7 - LIM domain only protein 7 - Homo sapiens (Human) - LMO7 gene apical plasma membrane, cell surface, cytoplasm, cytosol, focal adhesion, nuclear envelope, nucleus, ubiquitin ligase complex, ubiquitin-protein transferase activity, positive regulation of transcription by RNA polymerase II Indicus|evm.model.CM009502.1.284 Q5R893 H2B1_PONAB 87.705 0.937984 1.02381 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009502.1.285 Q6WVG3 KCD12_MOUSE 97.248 0.993884 1 Kctd12 - BTB/POZ domain-containing protein KCTD12 - Mus musculus (Mouse) - Kctd12 gene Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization. Indicus|evm.model.CM009502.1.287 A6NK06 IRG1_HUMAN 81.915 0.993644 0.981289 ACOD1 - Cis-aconitate decarboxylase - Homo sapiens (Human) - ACOD1 gene Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages (PubMed:23610393). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Plays a role in the embryo implantation (By similarity). Indicus|evm.model.CM009502.1.288 Q1ZYR0 CLN5_BOVIN 99.669 0.937695 0.896648 CLN5 - Ceroid-lipofuscinosis neuronal protein 5 - Bos taurus (Bovine) - CLN5 gene Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane. Indicus|evm.model.CM009502.1.289 Q9UKT7 FBXL3_HUMAN 97.669 0.664596 1.50467 FBXL3 - F-box/LRR-repeat protein 3 - Homo sapiens (Human) - FBXL3 gene Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855). Indicus|evm.model.CM009502.1.290 O75592 MYCB2_HUMAN 98.396 0.999572 1 MYCBP2 - E3 ubiquitin-protein ligase MYCBP2 - Homo sapiens (Human) - MYCBP2 gene Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (By similarity). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity). Regulates axon guidance in the olfactory system (By similarity). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (By similarity). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (PubMed:29643511). Regulates the internalization of TRPV1 in peripheral sensory neurons (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (PubMed:18308511, PubMed:27278822). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (PubMed:9689053). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Indicus|evm.model.CM009502.1.291 O95171 SCEL_HUMAN 74.513 0.995828 1.04506 SCEL - Sciellin - Homo sapiens (Human) - SCEL gene May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. Indicus|evm.model.CM009502.1.292 Q8ND83 SLAI1_HUMAN 96.000 0.994302 0.617958 SLAIN1 - SLAIN motif-containing protein 1 - Homo sapiens (Human) - SLAIN1 gene Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation. Indicus|evm.model.CM009502.1.293 P28088 EDNRB_BOVIN 100.000 0.995475 1.00227 EDNRB - Endothelin receptor type B precursor - Bos taurus (Bovine) - EDNRB gene Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009502.1.294 Q6HA08 ASTL_HUMAN 76.923 0.9375 0.222738 ASTL - Astacin-like metalloendopeptidase precursor - Homo sapiens (Human) - ASTL gene Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity). Indicus|evm.model.CM009502.1.295 P17208 PO4F1_MOUSE 100.000 0.981651 0.258907 Pou4f1 - POU domain, class 4, transcription factor 1 - Mus musculus (Mouse) - Pou4f1 gene Multifunctional transcription factor with different regions mediating its different effects (PubMed:10640682, PubMed:8621561, PubMed:9694219, PubMed:9722627). Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:8621561, PubMed:17668438). Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor (PubMed:12934100). Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain) (PubMed:9722627). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins (PubMed:8972215). Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity (PubMed:9448000). May positively regulate POU4F2 and POU4F3 (PubMed:8876243). Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord (PubMed:22326227). Plays a role in TNFSF11-mediated terminal osteoclast differentiation (PubMed:17668438). Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site (PubMed:12441296). Indicus|evm.model.CM009502.1.296 Q5W0B1 OBI1_HUMAN 88.981 0.997214 0.988981 OBI1 - ORC ubiquitin ligase 1 - Homo sapiens (Human) - OBI1 gene E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). Indicus|evm.model.CM009502.1.297 Q5T8P6 RBM26_HUMAN 96.723 0.997967 0.97716 RBM26 - RNA-binding protein 26 - Homo sapiens (Human) - RBM26 gene nucleus, RNA binding, negative regulation of phosphatase activity Indicus|evm.model.CM009502.1.298 Q9NV92 NFIP2_HUMAN 86.012 0.905405 1.10119 NDFIP2 - NEDD4 family-interacting protein 2 - Homo sapiens (Human) - NDFIP2 gene Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). Indicus|evm.model.CM009502.1.299 Q5R893 H2B1_PONAB 93.651 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009502.1.300 Q3SZ62 PGAM1_BOVIN 90.157 0.991525 0.929134 PGAM1 - Phosphoglycerate mutase 1 - Bos taurus (Bovine) - PGAM1 gene Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. Indicus|evm.model.CM009502.1.301 Q08E39 SPY2_BOVIN 100.000 0.993671 1.00317 SPRY2 - Protein sprouty homolog 2 - Bos taurus (Bovine) - SPRY2 gene Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (By similarity). Indicus|evm.model.CM009502.1.303 Q58CQ2 ARC1B_BOVIN 93.280 0.994609 0.997312 ARPC1B - Actin-related protein 2/3 complex subunit 1B - Bos taurus (Bovine) - ARPC1B gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Indicus|evm.model.CM009502.1.304 P15927 RFA2_HUMAN 86.667 0.97541 0.451852 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Indicus|evm.model.CM009502.1.306 P56966 GGPPS_BOVIN 98.039 0.980392 0.17 GGPS1 - Geranylgeranyl pyrophosphate synthase - Bos taurus (Bovine) - GGPS1 gene Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Indicus|evm.model.CM009502.1.307 A6H767 NP1L1_BOVIN 90.154 0.983607 0.780051 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009502.1.308 Q96PX8 SLIK1_HUMAN 99.138 0.997131 1.00144 SLITRK1 - SLIT and NTRK-like protein 1 precursor - Homo sapiens (Human) - SLITRK1 gene It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Enhances neuronal dendrite outgrowth (PubMed:16224024, PubMed:19640509). Indicus|evm.model.CM009502.1.310 Q9H5Y7 SLIK6_HUMAN 93.120 0.997628 1.00238 SLITRK6 - SLIT and NTRK-like protein 6 precursor - Homo sapiens (Human) - SLITRK6 gene Regulator of neurite outgrowth required for normal hearing and vision. Indicus|evm.model.CM009502.1.312 Q5RB63 HTSF1_PONAB 75.425 0.983051 1.01724 HTATSF1 - HIV Tat-specific factor 1 homolog - Pongo abelii (Sumatran orangutan) - HTATSF1 gene Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation (By similarity). Indicus|evm.model.CM009502.1.315 O94991 SLIK5_HUMAN 97.242 0.816133 0.879958 SLITRK5 - SLIT and NTRK-like protein 5 precursor - Homo sapiens (Human) - SLITRK5 gene Suppresses neurite outgrowth. Indicus|evm.model.CM009502.1.316 Q17QW2 TM39B_BOVIN 93.578 0.955752 0.229675 TMEM39B - Transmembrane protein 39B - Bos taurus (Bovine) - TMEM39B gene membrane Indicus|evm.model.CM009502.1.317 Q4R4J7 NUCL_MACFA 89.286 0.960526 0.320675 NCL - Nucleolin - Macaca fascicularis (Crab-eating macaque) - NCL gene Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity). Indicus|evm.model.CM009502.1.318 P19338 NUCL_HUMAN 88.732 0.201729 0.488732 NCL - Nucleolin - Homo sapiens (Human) - NCL gene Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Indicus|evm.model.CM009502.1.321 Q9UQ07 MOK_HUMAN 58.696 0.936842 0.22673 MOK - MAPK/MAK/MRK overlapping kinase - Homo sapiens (Human) - MOK gene Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. Indicus|evm.model.CM009502.1.323 O62640 PIAP_PIG 92.000 0.0774194 0.865922 PIAP - Putative inhibitor of apoptosis - Sus scrofa (Pig) - PIAP gene cytoplasm, nucleus, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ubiquitin protein ligase activity, negative regulation of apoptotic process, negative regulation of necroptotic process, positive regulation of protein ubiquitination, regulation of cell cycle Indicus|evm.model.CM009502.1.324 Q9R087 GPC6_MOUSE 98.661 0.62465 0.643243 Gpc6 - Glypican-6 precursor - Mus musculus (Mouse) - Gpc6 gene Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling (By similarity). Indicus|evm.model.CM009502.1.325 Q9Y625 GPC6_HUMAN 97.701 0.992366 0.472072 GPC6 - Glypican-6 precursor - Homo sapiens (Human) - GPC6 gene Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling. Indicus|evm.model.CM009502.1.326 Q95119 TYRP2_BOVIN 90.600 0.959916 0.916828 DCT - L-dopachrome tautomerase precursor - Bos taurus (Bovine) - DCT gene Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). Indicus|evm.model.CM009502.1.327 Q76LV2 HS90A_BOVIN 91.981 0.996656 0.815825 HSP90AA1 - Heat shock protein HSP 90-alpha - Bos taurus (Bovine) - HSP90AA1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response. Indicus|evm.model.CM009502.1.328 A6QLW2 TGDS_BOVIN 100.000 0.994382 1.00282 TGDS - dTDP-D-glucose 4,6-dehydratase - Bos taurus (Bovine) - TGDS gene dTDP-glucose 4,6-dehydratase activity Indicus|evm.model.CM009502.1.329 Q86V85 GP180_HUMAN 91.818 0.995465 1.00227 GPR180 - Integral membrane protein GPR180 precursor - Homo sapiens (Human) - GPR180 gene Indicus|evm.model.CM009502.1.330 Q811W0 SOX21_MOUSE 100.000 0.364017 0.865942 Sox21 - Transcription factor SOX-21 - Mus musculus (Mouse) - Sox21 gene May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells. Indicus|evm.model.CM009502.1.332 O15439 MRP4_HUMAN 92.025 0.407346 0.904151 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.333 E9Q236 MRP4_MOUSE 66.667 0.625 0.0784906 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Indicus|evm.model.CM009502.1.334 F1M3J4 MRP4_RAT 68.508 0.97043 0.280755 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Indicus|evm.model.CM009502.1.336 O15439 MRP4_HUMAN 49.367 0.935484 0.163774 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.337 O15439 MRP4_HUMAN 78.788 0.875 0.0845283 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.338 O15439 MRP4_HUMAN 83.333 0.0571705 0.778868 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.340 O15439 MRP4_HUMAN 75.410 0.631579 0.0716981 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.342 F1M3J4 MRP4_RAT 78.912 0.34192 0.322264 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Indicus|evm.model.CM009502.1.343 E9Q236 MRP4_MOUSE 75.000 0.668224 0.161509 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Indicus|evm.model.CM009502.1.344 O15439 MRP4_HUMAN 86.207 0.254464 0.169057 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.345 O15439 MRP4_HUMAN 76.415 0.115005 0.689057 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.346 O15439 MRP4_HUMAN 46.823 0.973856 0.230943 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.347 E9Q236 MRP4_MOUSE 88.889 0.235741 0.198491 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Indicus|evm.model.CM009502.1.348 O15439 MRP4_HUMAN 63.750 0.323276 0.525283 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.349 O15439 MRP4_HUMAN 68.358 0.886427 0.272453 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.350 O15439 MRP4_HUMAN 74.576 0.30984 1.13509 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.351 O15439 MRP4_HUMAN 66.267 0.938531 0.503396 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.352 F1M3J4 MRP4_RAT 80.392 0.961538 0.0392453 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Indicus|evm.model.CM009502.1.353 O15439 MRP4_HUMAN 77.397 0.917722 0.119245 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.355 O15439 MRP4_HUMAN 68.417 0.984206 0.907925 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.356 F1M3J4 MRP4_RAT 47.545 0.852868 0.302642 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Indicus|evm.model.CM009502.1.357 O15439 MRP4_HUMAN 76.562 0.548673 0.085283 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.358 F1M3J4 MRP4_RAT 79.787 0.673913 0.104151 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Indicus|evm.model.CM009502.1.359 O15439 MRP4_HUMAN 87.770 0.117048 0.889811 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.360 O15439 MRP4_HUMAN 68.566 0.981166 0.841509 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.361 O15439 MRP4_HUMAN 74.797 0.62383 0.886792 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.362 F1M3J4 MRP4_RAT 69.634 0.931373 0.153962 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Indicus|evm.model.CM009502.1.363 O15439 MRP4_HUMAN 78.531 0.470588 0.282264 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.364 O15439 MRP4_HUMAN 93.548 0.0500835 0.452075 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.365 O15439 MRP4_HUMAN 75.510 0.797814 0.138113 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.366 O15439 MRP4_HUMAN 72.955 0.98627 0.329811 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.367 E9Q236 MRP4_MOUSE 59.596 0.29697 0.249057 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Indicus|evm.model.CM009502.1.368 O15439 MRP4_HUMAN 80.392 0.961538 0.0392453 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009502.1.370 F1M3J4 MRP4_RAT 79.397 0.360656 0.41434 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Indicus|evm.model.CM009502.1.371 Q5E9L0 CLD10_BOVIN 100.000 0.991379 1.00433 CLDN10 - Claudin-10 - Bos taurus (Bovine) - CLDN10 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function. Indicus|evm.model.CM009502.1.372 Q86YF9 DZIP1_HUMAN 79.014 0.997701 1.00346 DZIP1 - Zinc finger protein DZIP1 - Homo sapiens (Human) - DZIP1 gene May participate in spermatogenesis via its interaction with DAZ1 (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954). Indicus|evm.model.CM009502.1.373 Q12887 COX10_HUMAN 72.449 0.460784 0.460497 COX10 - Protoheme IX farnesyltransferase, mitochondrial precursor - Homo sapiens (Human) - COX10 gene Converts protoheme IX and farnesyl diphosphate to heme O. Indicus|evm.model.CM009502.1.374 Q27968 DNJC3_BOVIN 99.802 0.99604 1.00198 DNAJC3 - DnaJ homolog subfamily C member 3 precursor - Bos taurus (Bovine) - DNAJC3 gene Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A (PubMed:7511204). May inhibit EIF2AK3/PERK activity (By similarity). Indicus|evm.model.CM009502.1.375 Q9NYU1 UGGG2_HUMAN 83.046 0.950126 1.04485 UGGT2 - UDP-glucose:glycoprotein glucosyltransferase 2 precursor - Homo sapiens (Human) - UGGT2 gene Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Indicus|evm.model.CM009502.1.376 Q9QYK4 H6ST3_MOUSE 89.873 0.751592 0.668085 Hs6st3 - Heparan-sulfate 6-O-sulfotransferase 3 - Mus musculus (Mouse) - Hs6st3 gene 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Indicus|evm.model.CM009502.1.378 Q8IZP7 H6ST3_HUMAN 92.797 0.928854 0.537155 HS6ST3 - Heparan-sulfate 6-O-sulfotransferase 3 - Homo sapiens (Human) - HS6ST3 gene 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Indicus|evm.model.CM009502.1.380 Q96P68 OXGR1_HUMAN 85.163 0.994083 1.00297 OXGR1 - 2-oxoglutarate receptor 1 - Homo sapiens (Human) - OXGR1 gene Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity). Indicus|evm.model.CM009502.1.381 Q5R4F5 MBNL2_PONAB 97.885 0.896739 0.986595 MBNL2 - Muscleblind-like protein 2 - Pongo abelii (Sumatran orangutan) - MBNL2 gene Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity). Indicus|evm.model.CM009502.1.382 Q5R988 RAP2A_PONAB 100.000 0.98913 1.00546 RAP2A - Ras-related protein Rap-2a precursor - Pongo abelii (Sumatran orangutan) - RAP2A gene Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (By similarity). Indicus|evm.model.CM009502.1.385 O00410 IPO5_HUMAN 98.549 0.970381 0.646308 IPO5 - Importin-5 - Homo sapiens (Human) - IPO5 gene Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Indicus|evm.model.CM009502.1.386 O00410 IPO5_HUMAN 98.652 0.994624 0.339107 IPO5 - Importin-5 - Homo sapiens (Human) - IPO5 gene Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Indicus|evm.model.CM009502.1.387 Q9Y4F1 FARP1_HUMAN 96.491 0.982456 0.0545455 FARP1 - FERM, ARHGEF and pleckstrin domain-containing protein 1 - Homo sapiens (Human) - FARP1 gene Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). Indicus|evm.model.CM009502.1.388 Q9Y4F1 FARP1_HUMAN 91.010 0.969578 0.97512 FARP1 - FERM, ARHGEF and pleckstrin domain-containing protein 1 - Homo sapiens (Human) - FARP1 gene Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). Indicus|evm.model.CM009502.1.389 Q99KH8 STK24_MOUSE 84.834 0.783784 1.11601 Stk24 - Serine/threonine-protein kinase 24 - Mus musculus (Mouse) - Stk24 gene Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. Acts as a key regulator of axon regeneration in the optic nerve and radial nerve (By similarity). Indicus|evm.model.CM009502.1.390 Q8WMX5 S15A1_CANLF 83.310 0.960437 1.03531 SLC15A1 - Solute carrier family 15 member 1 - Canis lupus familiaris (Dog) - SLC15A1 gene Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen. Indicus|evm.model.CM009502.1.391 Q9BZ29 DOCK9_HUMAN 92.979 0.961318 1.01208 DOCK9 - Dedicator of cytokinesis protein 9 - Homo sapiens (Human) - DOCK9 gene Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. Indicus|evm.model.CM009502.1.394 P58021 TM9S2_MOUSE 99.035 0.996146 0.783988 Tm9sf2 - Transmembrane 9 superfamily member 2 precursor - Mus musculus (Mouse) - Tm9sf2 gene In the intracellular compartments, may function as a channel or small molecule transporter. Indicus|evm.model.CM009502.1.395 Q8N0X4 CLYBL_HUMAN 90.096 0.912281 1.00588 CLYBL - Citramalyl-CoA lyase, mitochondrial precursor - Homo sapiens (Human) - CLYBL gene Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:29056341, PubMed:24334609). Also displays malyl-CoA thioesterase activity (PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341). Indicus|evm.model.CM009502.1.397 Q7TQ40 ZIC5_MOUSE 95.205 0.941558 0.247588 Zic5 - Zinc finger protein ZIC 5 - Mus musculus (Mouse) - Zic5 gene Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA. Indicus|evm.model.CM009502.1.398 O95409 ZIC2_HUMAN 99.777 0.881657 0.953008 ZIC2 - Zinc finger protein ZIC 2 - Homo sapiens (Human) - ZIC2 gene Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. Indicus|evm.model.CM009502.1.400 P0DTA4 PCCA_PIG 93.648 0.998185 0.754795 PCCA - Propionyl-CoA carboxylase alpha chain, mitochondrial precursor - Sus scrofa (Pig) - PCCA gene This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:13752080). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:13752080). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then tranfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:13752080). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (PubMed:13752080). Indicus|evm.model.CM009502.1.401 Q0VFX9 GGACT_BOVIN 98.810 0.521875 1.90476 GGACT - Gamma-glutamylaminecyclotransferase - Bos taurus (Bovine) - GGACT gene Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine. Indicus|evm.model.CM009502.1.402 Q5T4D3 TMTC4_HUMAN 91.228 0.997301 1 TMTC4 - Protein O-mannosyl-transferase TMTC4 - Homo sapiens (Human) - TMTC4 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Indicus|evm.model.CM009502.1.403 Q8IZF0 NALCN_HUMAN 95.742 0.998817 0.972957 NALCN - Sodium leak channel non-selective protein - Homo sapiens (Human) - NALCN gene Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (By similarity). Indicus|evm.model.CM009502.1.404 O95965 ITGBL_HUMAN 94.334 0.99435 0.716599 ITGBL1 - Integrin beta-like protein 1 precursor - Homo sapiens (Human) - ITGBL1 gene focal adhesion, plasma membrane, integrin binding, cell adhesion, cell adhesion mediated by integrin, cell migration, cell-matrix adhesion, integrin-mediated signaling pathway Indicus|evm.model.CM009502.1.405 Q92915 FGF14_HUMAN 98.529 0.813253 0.672065 FGF14 - Fibroblast growth factor 14 - Homo sapiens (Human) - FGF14 gene Probably involved in nervous system development and function. Indicus|evm.model.CM009502.1.408 A5PK39 TPP2_BOVIN 99.920 0.9984 1.0008 TPP2 - Tripeptidyl-peptidase 2 - Bos taurus (Bovine) - TPP2 gene Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity). Indicus|evm.model.CM009502.1.409 A6QP81 MT21C_BOVIN 100.000 0.850498 1.17121 METTL21C - Protein-lysine methyltransferase METTL21C - Bos taurus (Bovine) - METTL21C gene Protein-lysine methyltransferase. Indicus|evm.model.CM009502.1.411 Q3ZC52 TEX30_BOVIN 100.000 0.777003 1.28125 TEX30 - Testis-expressed protein 30 - Bos taurus (Bovine) - TEX30 gene Indicus|evm.model.CM009502.1.413 Q6UW63 PLGT2_HUMAN 93.426 0.996024 1.00199 POGLUT2 - Protein O-glucosyltransferase 2 precursor - Homo sapiens (Human) - POGLUT2 gene Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1 and NOTCH3 (PubMed:30127001). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001). Indicus|evm.model.CM009502.1.414 Q86UB2 BIVM_HUMAN 92.644 0.996024 1 BIVM - Basic immunoglobulin-like variable motif-containing protein - Homo sapiens (Human) - BIVM gene extracellular space Indicus|evm.model.CM009502.1.415 P28715 ERCC5_HUMAN 71.547 0.98527 1.03035 ERCC5 - DNA excision repair protein ERCC-5 - Homo sapiens (Human) - ERCC5 gene Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:8206890, PubMed:8090225, PubMed:8078765, PubMed:7651464, PubMed:32821917, PubMed:32522879). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:8090225, PubMed:8078765, PubMed:32821917, PubMed:32522879). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). Indicus|evm.model.CM009502.1.416 Q58DC7 MT21E_BOVIN 100.000 0.993127 1.00345 METTL21E - Protein-lysine methyltransferase METTL21E - Bos taurus (Bovine) - METTL21E gene Protein-lysine methyltransferase. Indicus|evm.model.CM009502.1.417 Q60414 NTCP2_CRIGR 81.308 0.930131 0.658046 SLC10A2 - Ileal sodium/bile acid cotransporter - Cricetulus griseus (Chinese hamster) - SLC10A2 gene Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity). Indicus|evm.model.CM009502.1.420 O46415 FRIL_BOVIN 61.458 0.979381 0.554286 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009502.1.421 P52799 EFNB2_HUMAN 96.233 0.848397 1.03003 EFNB2 - Ephrin-B2 precursor - Homo sapiens (Human) - EFNB2 gene Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. Indicus|evm.model.CM009502.1.422 Q9NWB6 ARGL1_HUMAN 99.545 0.969027 0.827839 ARGLU1 - Arginine and glutamate-rich protein 1 - Homo sapiens (Human) - ARGLU1 gene Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. Indicus|evm.model.CM009502.1.425 P35232 PHB_HUMAN 95.722 0.673913 1.01471 PHB - Prohibitin - Homo sapiens (Human) - PHB gene Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). Indicus|evm.model.CM009502.1.428 A4IFM1 F155A_BOVIN 100.000 0.635135 0.323851 FAM155A - Transmembrane protein FAM155A - Bos taurus (Bovine) - FAM155A gene plasma membrane, calcium ion import across plasma membrane Indicus|evm.model.CM009502.1.429 A4IFM1 F155A_BOVIN 96.667 0.401361 0.321663 FAM155A - Transmembrane protein FAM155A - Bos taurus (Bovine) - FAM155A gene plasma membrane, calcium ion import across plasma membrane Indicus|evm.model.CM009502.1.430 P80272 HMGN2_PIG 95.506 0.967033 1.01111 HMGN2 - Non-histone chromosomal protein HMG-17 - Sus scrofa (Pig) - HMGN2 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). Indicus|evm.model.CM009502.1.433 A4IFM1 F155A_BOVIN 98.382 0.959502 0.702407 FAM155A - Transmembrane protein FAM155A - Bos taurus (Bovine) - FAM155A gene plasma membrane, calcium ion import across plasma membrane Indicus|evm.model.CM009502.1.434 P49917 DNLI4_HUMAN 89.352 0.997807 1.0011 LIG4 - DNA ligase 4 - Homo sapiens (Human) - LIG4 gene Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Indicus|evm.model.CM009502.1.435 Q7L211 ABHDD_HUMAN 97.923 0.994083 1.00297 ABHD13 - Protein ABHD13 - Homo sapiens (Human) - ABHD13 gene membrane, palmitoyl-(protein) hydrolase activity Indicus|evm.model.CM009502.1.436 Q9Y275 TN13B_HUMAN 63.889 0.92517 0.515789 TNFSF13B - Tumor necrosis factor ligand superfamily member 13B - Homo sapiens (Human) - TNFSF13B gene Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Indicus|evm.model.CM009502.1.437 Q9Y275 TN13B_HUMAN 93.600 0.837838 0.519298 TNFSF13B - Tumor necrosis factor ligand superfamily member 13B - Homo sapiens (Human) - TNFSF13B gene Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Indicus|evm.model.CM009502.1.438 Q9Y6X6 MYO16_HUMAN 83.333 0.943174 0.776642 MYO16 - Unconventional myosin-XVI - Homo sapiens (Human) - MYO16 gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). Indicus|evm.model.CM009502.1.442 Q9Y4H2 IRS2_HUMAN 95.349 0.0851703 0.745889 IRS2 - Insulin receptor substrate 2 - Homo sapiens (Human) - IRS2 gene May mediate the control of various cellular processes by insulin. Indicus|evm.model.CM009502.1.443 Q7SIB2 CO4A1_BOVIN 99.757 0.99757 0.986219 COL4A1 - Collagen alpha-1(IV) chain precursor - Bos taurus (Bovine) - COL4A1 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Indicus|evm.model.CM009502.1.444 Q7SIB3 CO4A2_BOVIN 99.559 0.129217 7.70485 COL4A2 - Collagen alpha-2(IV) chain - Bos taurus (Bovine) - COL4A2 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth (By similarity). Indicus|evm.model.CM009502.1.445 Q9NX57 RAB20_HUMAN 79.060 0.991379 0.991453 RAB20 - Ras-related protein Rab-20 - Homo sapiens (Human) - RAB20 gene Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Indicus|evm.model.CM009502.1.446 E1BNQ4 NNRD_BOVIN 99.329 0.993311 0.908815 NAXD - ATP-dependent (S)-NAD(P)H-hydrate dehydratase precursor - Bos taurus (Bovine) - NAXD gene Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Indicus|evm.model.CM009502.1.447 Q2KIF8 SYCM_BOVIN 96.032 0.92976 0.974775 CARS2 - Cysteine--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - CARS2 gene cytoplasm, ATP binding, cysteine-tRNA ligase activity, cysteinyl-tRNA aminoacylation Indicus|evm.model.CM009502.1.448 Q9NXR5 ANR10_HUMAN 77.429 0.919786 0.890476 ANKRD10 - Ankyrin repeat domain-containing protein 10 - Homo sapiens (Human) - ANKRD10 gene Indicus|evm.model.CM009502.1.449 Q9QXV3 ING1_MOUSE 89.451 0.87037 0.967742 Ing1 - Inhibitor of growth protein 1 - Mus musculus (Mouse) - Ing1 gene Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor. Indicus|evm.model.CM009502.1.451 Q14155 ARHG7_HUMAN 94.490 0.57193 1.06476 ARHGEF7 - Rho guanine nucleotide exchange factor 7 - Homo sapiens (Human) - ARHGEF7 gene Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. Indicus|evm.model.CM009502.1.452 Q3SZT4 TEX29_BOVIN 97.959 0.986486 1.0068 TEX29 - Testis-expressed protein 29 - Bos taurus (Bovine) - TEX29 gene Indicus|evm.model.CM009502.1.463 P53783 SOX1_MOUSE 93.333 0.75 0.286445 Sox1 - Transcription factor SOX-1 - Mus musculus (Mouse) - Sox1 gene Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). Indicus|evm.model.CM009502.1.468 Q96CW5 GCP3_HUMAN 91.731 0.997797 1.0011 TUBGCP3 - Gamma-tubulin complex component 3 - Homo sapiens (Human) - TUBGCP3 gene Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Indicus|evm.model.CM009502.1.469 P98196 AT11A_HUMAN 91.750 0.944302 1.0291 ATP11A - Phospholipid-transporting ATPase IH - Homo sapiens (Human) - ATP11A gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:25947375, PubMed:26567335, PubMed:29799007, PubMed:30018401). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. Indicus|evm.model.CM009502.1.470 O15068 MCF2L_HUMAN 54.902 0.168919 0.260334 MCF2L - Guanine nucleotide exchange factor DBS - Homo sapiens (Human) - MCF2L gene Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). Indicus|evm.model.CM009502.1.471 Q63406 MCF2L_RAT 84.463 0.908233 1.0148 Mcf2l - Guanine nucleotide exchange factor DBS - Rattus norvegicus (Rat) - Mcf2l gene Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. Indicus|evm.model.CM009502.1.472 P22457 FA7_BOVIN 99.776 0.995536 1.00224 F7 - Coagulation factor VII precursor - Bos taurus (Bovine) - F7 gene Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Indicus|evm.model.CM009502.1.473 P00743 FA10_BOVIN 99.593 0.995943 1.00203 F10 - Coagulation factor X precursor - Bos taurus (Bovine) - F10 gene Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Indicus|evm.model.CM009502.1.474 P00744 PROZ_BOVIN 79.514 0.814371 0.843434 PROZ - Vitamin K-dependent protein Z - Bos taurus (Bovine) - PROZ gene Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Indicus|evm.model.CM009502.1.475 Q2TBN6 PCID2_BOVIN 96.602 0.99505 0.990196 PCID2 - PCI domain-containing protein 2 - Bos taurus (Bovine) - PCID2 gene Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells (By similarity). Indicus|evm.model.CM009502.1.476 Q13619 CUL4A_HUMAN 94.225 0.979079 0.944664 CUL4A - Cullin-4A - Homo sapiens (Human) - CUL4A gene Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). With CUL4B, contributes to ribosome biogenesis (PubMed:26711351). Indicus|evm.model.CM009502.1.477 Q05204 LAMP1_BOVIN 98.747 0.872807 1.11491 LAMP1 - Lysosome-associated membrane glycoprotein 1 precursor - Bos taurus (Bovine) - LAMP1 gene caveola, cytolytic granule membrane, endosome membrane, late endosome membrane, lysosomal membrane, membrane raft, plasma membrane, establishment of protein localization to organelle, protein stabilization Indicus|evm.model.CM009502.1.478 Q5TC63 GRTP1_HUMAN 80.488 0.703226 1.38393 GRTP1 - Growth hormone-regulated TBC protein 1 - Homo sapiens (Human) - GRTP1 gene May act as a GTPase-activating protein for Rab family protein(s). Indicus|evm.model.CM009502.1.479 Q3ZBM1 ARHL1_BOVIN 99.153 0.213551 4.66949 ADPRHL1 - [Protein ADP-ribosylarginine] hydrolase-like protein 1 - Bos taurus (Bovine) - ADPRHL1 gene autophagosome, recycling endosome, GTPase activator activity, activation of GTPase activity, intracellular protein transport, regulation of autophagosome assembly Indicus|evm.model.CM009502.1.480 Q8BZJ7 DCNL2_MOUSE 89.500 0.952153 0.80695 Dcun1d2 - DCN1-like protein 2 - Mus musculus (Mouse) - Dcun1d2 gene Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity. Indicus|evm.model.CM009502.1.481 Q8BH01 TMCO3_MOUSE 81.416 0.99705 1 Tmco3 - Transmembrane and coiled-coil domain-containing protein 3 precursor - Mus musculus (Mouse) - Tmco3 gene Probable Na(+)/H(+) antiporter. Indicus|evm.model.CM009502.1.482 Q17QZ4 TFDP1_BOVIN 100.000 0.995134 1.00244 TFDP1 - Transcription factor Dp-1 - Bos taurus (Bovine) - TFDP1 gene Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (By similarity). Indicus|evm.model.CM009502.1.483 P18434 ATP4B_PIG 90.000 0.993127 1.00345 ATP4B - Potassium-transporting ATPase subunit beta - Sus scrofa (Pig) - ATP4B gene The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (PubMed:29618813, PubMed:19387495). Indicus|evm.model.CM009502.1.484 P28327 GRK1_BOVIN 100.000 0.996441 1.00178 GRK1 - Rhodopsin kinase GRK1 precursor - Bos taurus (Bovine) - GRK1 gene Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:12686556, PubMed:16675451, PubMed:21299498). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity). Indicus|evm.model.CM009502.1.485 Q8WV15 T255B_HUMAN 64.724 0.983389 0.923313 TMEM255B - Transmembrane protein 255B - Homo sapiens (Human) - TMEM255B gene Indicus|evm.model.CM009502.1.486 Q14393 GAS6_HUMAN 81.162 0.874656 1.0708 GAS6 - Growth arrest-specific protein 6 precursor - Homo sapiens (Human) - GAS6 gene Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Indicus|evm.model.CM009502.1.487 A0A1B0GUA9 CM046_HUMAN 57.009 0.990291 0.971698 C13orf46 - Uncharacterized protein C13orf46 - Homo sapiens (Human) - C13orf46 gene Indicus|evm.model.CM009502.1.488 Q28013 RASA3_BOVIN 99.640 0.997605 1.0012 RASA3 - Ras GTPase-activating protein 3 - Bos taurus (Bovine) - RASA3 gene Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4). Indicus|evm.model.CM009502.1.490 A0A1B0GU71 C97D2_HUMAN 59.794 0.571429 1.71429 CFAP97D2 - Uncharacterized protein CFAP97D2 - Homo sapiens (Human) - CFAP97D2 gene Indicus|evm.model.CM009502.1.491 Q13042 CDC16_HUMAN 97.742 0.996779 1.00161 CDC16 - Cell division cycle protein 16 homolog - Homo sapiens (Human) - CDC16 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Indicus|evm.model.CM009502.1.492 Q9H1J1 REN3A_HUMAN 76.316 0.883041 1.07773 UPF3A - Regulator of nonsense transcripts 3A - Homo sapiens (Human) - UPF3A gene Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. Indicus|evm.model.CM009502.1.493 Q96JM3 CHAP1_HUMAN 86.871 0.997516 0.991379 CHAMP1 - Chromosome alignment-maintaining phosphoprotein 1 - Homo sapiens (Human) - CHAMP1 gene Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. Indicus|evm.model.CM009502.1.494 Q8VGS1 O1038_MOUSE 70.861 0.993377 0.473354 Olfr1038 - Olfactory receptor 1038 - Mus musculus (Mouse) - Olfr1038 gene Potential odorant receptor. Indicus|evm.model.CM009503.1.1 Q9UPS8 ANR26_HUMAN 59.286 0.165279 0.491813 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.3 Q8NH73 OR4S2_HUMAN 83.234 0.988024 0.536977 OR4S2 - Olfactory receptor 4S2 - Homo sapiens (Human) - OR4S2 gene Odorant receptor. Indicus|evm.model.CM009503.1.4 Q8NGL7 OR4P4_HUMAN 51.923 0.837398 0.394231 OR4P4 - Olfactory receptor 4P4 - Homo sapiens (Human) - OR4P4 gene Odorant receptor. Indicus|evm.model.CM009503.1.5 Q5JUK9 PAGE3_HUMAN 45.556 0.514451 1.53097 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Indicus|evm.model.CM009503.1.6 Q5JUK9 PAGE3_HUMAN 51.579 0.746032 1.11504 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Indicus|evm.model.CM009503.1.7 Q8NH72 OR4C6_HUMAN 65.818 0.981273 0.864078 OR4C6 - Olfactory receptor 4C6 - Homo sapiens (Human) - OR4C6 gene Odorant receptor. Indicus|evm.model.CM009503.1.9 Q9H1E5 TMX4_HUMAN 79.656 0.985673 1 TMX4 - Thioredoxin-related transmembrane protein 4 precursor - Homo sapiens (Human) - TMX4 gene nuclear inner membrane Indicus|evm.model.CM009503.1.10 P10894 PLCB1_BOVIN 96.024 0.998206 0.916941 PLCB1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 - Bos taurus (Bovine) - PLCB1 gene Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier. Indicus|evm.model.CM009503.1.12 Q07722 PLCB4_BOVIN 95.308 0.855652 1.12414 PLCB4 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 - Bos taurus (Bovine) - PLCB4 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. Indicus|evm.model.CM009503.1.13 A4FV27 LAMP5_BOVIN 99.643 0.992883 1.00357 LAMP5 - Lysosome-associated membrane glycoprotein 5 precursor - Bos taurus (Bovine) - LAMP5 gene Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. Indicus|evm.model.CM009503.1.14 Q9P286 PAK5_HUMAN 94.159 0.997222 1.00139 PAK5 - Serine/threonine-protein kinase PAK 5 - Homo sapiens (Human) - PAK5 gene Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. Indicus|evm.model.CM009503.1.15 Q99877 H2B1N_HUMAN 92.135 0.967033 0.722222 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009503.1.17 Q9NU02 ANKE1_HUMAN 87.484 0.996139 1.00129 ANKEF1 - Ankyrin repeat and EF-hand domain-containing protein 1 - Homo sapiens (Human) - ANKEF1 gene Indicus|evm.model.CM009503.1.18 P60881 SNP25_RAT 95.631 0.990338 1.00485 Snap25 - Synaptosomal-associated protein 25 - Rattus norvegicus (Rat) - Snap25 gene t-SNARE involved in the molecular regulation of neurotransmitter release (PubMed:8243676, PubMed:8103915). May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (PubMed:12403834). Indicus|evm.model.CM009503.1.19 Q9NPJ1 MKKS_HUMAN 79.474 0.866058 1.15263 MKKS - McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin - Homo sapiens (Human) - MKKS gene Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis (PubMed:28753627). Indicus|evm.model.CM009503.1.20 Q5VYV7 SLX4I_HUMAN 72.289 0.904412 0.666667 SLX4IP - Protein SLX4IP - Homo sapiens (Human) - SLX4IP gene Indicus|evm.model.CM009503.1.21 P78504 JAG1_HUMAN 95.813 0.998359 1.00082 JAG1 - Protein jagged-1 precursor - Homo sapiens (Human) - JAG1 gene Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). Indicus|evm.model.CM009503.1.25 Q7JGF7 SRY_BOSIN 100.000 0.991304 1.00437 SRY - Sex-determining region Y protein - Bos indicus (Zebu) - SRY gene Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Indicus|evm.model.CM009503.1.27 M3XQV7 BTBD3_MUSPF 97.180 0.996205 0.990602 BTBD3 - BTB/POZ domain-containing protein 3 - Mustela putorius furo (European domestic ferret) - BTBD3 gene Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed. Indicus|evm.model.CM009503.1.31 O15270 SPTC2_HUMAN 72.924 0.572327 0.848754 SPTLC2 - Serine palmitoyltransferase 2 - Homo sapiens (Human) - SPTLC2 gene Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity). Indicus|evm.model.CM009503.1.32 B1AKI9 ISM1_HUMAN 92.840 0.947846 0.950431 ISM1 - Isthmin-1 precursor - Homo sapiens (Human) - ISM1 gene Acts as an angiogenesis inhibitor. Indicus|evm.model.CM009503.1.33 Q9H6P5 TASP1_HUMAN 97.949 0.989796 0.466667 TASP1 - Threonine aspartase 1 - Homo sapiens (Human) - TASP1 gene Protease responsible for KMT2A/MLL1 processing and activation (PubMed:14636557). It also activates KMT2D/MLL2 (By similarity). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (By similarity) (PubMed:14636557). Indicus|evm.model.CM009503.1.34 Q9H501 ESF1_HUMAN 82.771 0.997672 1.0094 ESF1 - ESF1 homolog - Homo sapiens (Human) - ESF1 gene May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). Indicus|evm.model.CM009503.1.35 Q5TEU4 NDUF5_HUMAN 88.323 0.962428 1.0029 NDUFAF5 - Arginine-hydroxylase NDUFAF5, mitochondrial precursor - Homo sapiens (Human) - NDUFAF5 gene Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages (PubMed:18940309, PubMed:27226634). Acts by mediating hydroxylation of 'Arg-111' of NDUFS7 (PubMed:27226634). May also have methyltransferase activity (Probable). Indicus|evm.model.CM009503.1.36 Q5TEA6 SE1L2_HUMAN 89.971 0.997097 1.00145 SEL1L2 - Protein sel-1 homolog 2 precursor - Homo sapiens (Human) - SEL1L2 gene Hrd1p ubiquitin ligase ERAD-L complex, ubiquitin-dependent ERAD pathway Indicus|evm.model.CM009503.1.37 Q9NZU0 FLRT3_HUMAN 97.535 0.996923 1.00154 FLRT3 - Leucine-rich repeat transmembrane protein FLRT3 precursor - Homo sapiens (Human) - FLRT3 gene Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity). Indicus|evm.model.CM009503.1.38 Q3UYG8 MACD2_MOUSE 97.436 0.372549 0.214737 Macrod2 - ADP-ribose glycohydrolase MACROD2 - Mus musculus (Mouse) - Macrod2 gene Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Indicus|evm.model.CM009503.1.40 A1Z1Q3 MACD2_HUMAN 88.095 0.369369 0.261176 MACROD2 - ADP-ribose glycohydrolase MACROD2 - Homo sapiens (Human) - MACROD2 gene Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Indicus|evm.model.CM009503.1.41 A1Z1Q3 MACD2_HUMAN 92.308 0.206612 0.284706 MACROD2 - ADP-ribose glycohydrolase MACROD2 - Homo sapiens (Human) - MACROD2 gene Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Indicus|evm.model.CM009503.1.42 A1Z1Q3 MACD2_HUMAN 70.755 0.820312 0.301176 MACROD2 - ADP-ribose glycohydrolase MACROD2 - Homo sapiens (Human) - MACROD2 gene Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Indicus|evm.model.CM009503.1.43 P62752 RL23A_RAT 65.517 0.817308 0.666667 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009503.1.44 Q96L93 KI16B_HUMAN 85.812 0.998457 0.984055 KIF16B - Kinesin-like protein KIF16B - Homo sapiens (Human) - KIF16B gene Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. Indicus|evm.model.CM009503.1.46 P08579 RU2B_HUMAN 99.111 0.99115 1.00444 SNRPB2 - U2 small nuclear ribonucleoprotein B'' - Homo sapiens (Human) - SNRPB2 gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128). Indicus|evm.model.CM009503.1.47 Q9NRC9 OTOR_HUMAN 88.372 0.984615 1.01562 OTOR - Otoraplin precursor - Homo sapiens (Human) - OTOR gene cartilage condensation, sensory perception of sound Indicus|evm.model.CM009503.1.48 A4IFH4 PSF1_BOVIN 60.606 0.619946 1.89286 GINS1 - DNA replication complex GINS protein PSF1 - Bos taurus (Bovine) - GINS1 gene Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. Indicus|evm.model.CM009503.1.49 Q9UPS8 ANR26_HUMAN 61.000 0.923077 0.121637 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.50 Q9UPS8 ANR26_HUMAN 69.492 0.852941 0.0397661 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.51 Q0EEE2 PTHD3_MOUSE 49.083 0.964444 0.248344 Ptchd3 - Patched domain-containing protein 3 - Mus musculus (Mouse) - Ptchd3 gene May play a role in sperm development or sperm function. Indicus|evm.model.CM009503.1.52 Q8TBE9 NANP_HUMAN 94.672 0.573113 1.70968 NANP - N-acylneuraminate-9-phosphatase - Homo sapiens (Human) - NANP gene cytosol, N-acylneuraminate-9-phosphatase activity, N-acetylneuraminate biosynthetic process Indicus|evm.model.CM009503.1.53 Q9Y2I6 NINL_HUMAN 70.697 0.674464 0.742402 NINL - Ninein-like protein - Homo sapiens (Human) - NINL gene Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. Indicus|evm.model.CM009503.1.54 Q9UPS8 ANR26_HUMAN 69.444 0.11263 0.898246 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.55 Q9UPS8 ANR26_HUMAN 54.704 0.169611 0.827485 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.57 Q9UPS8 ANR26_HUMAN 63.953 0.215223 0.445614 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.58 Q9UPS8 ANR26_HUMAN 62.857 0.146008 0.556725 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.60 Q9BQI4 CCDC3_HUMAN 91.935 0.978836 0.7 CCDC3 - Coiled-coil domain-containing protein 3 precursor - Homo sapiens (Human) - CCDC3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity). Indicus|evm.model.CM009503.1.63 Q8IU85 KCC1D_HUMAN 97.746 0.669187 1.37403 CAMK1D - Calcium/calmodulin-dependent protein kinase type 1D - Homo sapiens (Human) - CAMK1D gene Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. Indicus|evm.model.CM009503.1.65 Q2YDG3 CD123_BOVIN 99.701 0.994048 1.00299 CDC123 - Cell division cycle protein 123 homolog - Bos taurus (Bovine) - CDC123 gene Required for S phase entry of the cell cycle. Indicus|evm.model.CM009503.1.66 Q9UKK9 NUDT5_HUMAN 88.426 0.981735 1 NUDT5 - ADP-sugar pyrophosphatase - Homo sapiens (Human) - NUDT5 gene Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). Indicus|evm.model.CM009503.1.67 Q9JLR1 S61A2_MOUSE 100.000 0.995807 1.0021 Sec61a2 - Protein transport protein Sec61 subunit alpha isoform 2 - Mus musculus (Mouse) - Sec61a2 gene Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). Indicus|evm.model.CM009503.1.68 Q5R7H0 DHTK1_PONAB 90.440 0.9859 1.00326 DHTKD1 - Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - DHTKD1 gene The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Indicus|evm.model.CM009503.1.69 Q9HAU5 RENT2_HUMAN 97.563 0.998428 1 UPF2 - Regulator of nonsense transcripts 2 - Homo sapiens (Human) - UPF2 gene Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. Indicus|evm.model.CM009503.1.70 Q8C5R2 PRSR2_MOUSE 64.509 0.995604 0.96603 Proser2 - Proline and serine-rich protein 2 - Mus musculus (Mouse) - Proser2 gene Indicus|evm.model.CM009503.1.74 Q96DC8 ECHD3_HUMAN 82.000 0.993355 0.993399 ECHDC3 - Enoyl-CoA hydratase domain-containing protein 3, mitochondrial precursor - Homo sapiens (Human) - ECHDC3 gene May play a role in fatty acid biosynthesis and insulin sensitivity. Indicus|evm.model.CM009503.1.75 Q92738 US6NL_HUMAN 79.162 0.997546 0.9843 USP6NL - USP6 N-terminal-like protein - Homo sapiens (Human) - USP6NL gene Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. Indicus|evm.model.CM009503.1.76 Q5R8Y8 CELF2_PONAB 99.531 0.979263 0.854331 CELF2 - CUGBP Elav-like family member 2 - Pongo abelii (Sumatran orangutan) - CELF2 gene RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity). Indicus|evm.model.CM009503.1.80 Q9H5I5 PIEZ2_HUMAN 73.469 0.977528 0.0323401 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Indicus|evm.model.CM009503.1.81 Q5R893 H2B1_PONAB 95.238 0.984 0.992063 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009503.1.84 Q08DV0 GATA3_BOVIN 99.550 0.995506 1.00451 GATA3 - Trans-acting T-cell-specific transcription factor GATA-3 - Bos taurus (Bovine) - GATA3 gene Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses (By similarity). Indicus|evm.model.CM009503.1.85 Q5VWG9 TAF3_HUMAN 88.627 0.997856 1.00431 TAF3 - Transcription initiation factor TFIID subunit 3 - Homo sapiens (Human) - TAF3 gene Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. Indicus|evm.model.CM009503.1.86 P05631 ATPG_BOVIN 100.000 0.993311 1.00336 ATP5F1C - ATP synthase subunit gamma, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1C gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Indicus|evm.model.CM009503.1.87 O60870 KIN17_HUMAN 97.201 0.994911 1 KIN - DNA/RNA-binding protein KIN17 - Homo sapiens (Human) - KIN gene Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. Indicus|evm.model.CM009503.1.88 O02668 ITIH2_PIG 86.575 0.926471 1.09091 ITIH2 - Inter-alpha-trypsin inhibitor heavy chain H2 precursor - Sus scrofa (Pig) - ITIH2 gene May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Indicus|evm.model.CM009503.1.89 Q5RKI1 IF4A2_RAT 100.000 0.225914 0.739558 Eif4a2 - Eukaryotic initiation factor 4A-II - Rattus norvegicus (Rat) - Eif4a2 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Indicus|evm.model.CM009503.1.90 A2VE29 ITIH5_BOVIN 92.121 0.910145 0.367021 ITIH5 - Inter-alpha-trypsin inhibitor heavy chain H5 precursor - Bos taurus (Bovine) - ITIH5 gene May act as a tumor suppressor. Indicus|evm.model.CM009503.1.92 A2VE29 ITIH5_BOVIN 93.245 0.989418 0.804255 ITIH5 - Inter-alpha-trypsin inhibitor heavy chain H5 precursor - Bos taurus (Bovine) - ITIH5 gene May act as a tumor suppressor. Indicus|evm.model.CM009503.1.94 Q5VUG0 SMBT2_HUMAN 90.940 0.997758 0.997763 SFMBT2 - Scm-like with four MBT domains protein 2 - Homo sapiens (Human) - SFMBT2 gene Transcriptional repressor of HOXB13 gene. Indicus|evm.model.CM009503.1.96 Q04759 KPCT_HUMAN 96.034 0.965753 1.03399 PRKCQ - Protein kinase C theta type - Homo sapiens (Human) - PRKCQ gene Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Indicus|evm.model.CM009503.1.97 Q5R9C1 F263_PONAB 95.876 0.966068 0.974708 PFKFB3 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 - Pongo abelii (Sumatran orangutan) - PFKFB3 gene Synthesis and degradation of fructose 2,6-bisphosphate. Indicus|evm.model.CM009503.1.98 Q96I25 SPF45_HUMAN 98.933 0.757085 1.23192 RBM17 - Splicing factor 45 - Homo sapiens (Human) - RBM17 gene Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. Indicus|evm.model.CM009503.1.100 P12342 IL2RA_BOVIN 98.010 0.58651 1.24 IL2RA - Interleukin-2 receptor subunit alpha precursor - Bos taurus (Bovine) - IL2RA gene Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. Indicus|evm.model.CM009503.1.101 Q13261 I15RA_HUMAN 55.230 0.819788 1.05993 IL15RA - Interleukin-15 receptor subunit alpha precursor - Homo sapiens (Human) - IL15RA gene High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910). Indicus|evm.model.CM009503.1.102 Q8NFZ0 FBH1_HUMAN 88.721 0.935849 1.0163 FBH1 - F-box DNA helicase 1 - Homo sapiens (Human) - FBH1 gene 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578). Indicus|evm.model.CM009503.1.103 Q9UPS8 ANR26_HUMAN 62.617 0.6 0.309942 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.104 Q9UPS8 ANR26_HUMAN 67.442 0.863071 0.140936 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.105 Q6ZQ12 NINL_MOUSE 59.055 0.369258 0.812052 Ninl - Ninein-like protein - Mus musculus (Mouse) - Ninl gene Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly (By similarity). Indicus|evm.model.CM009503.1.106 Q9Y2I6 NINL_HUMAN 64.085 0.532258 0.17945 NINL - Ninein-like protein - Homo sapiens (Human) - NINL gene Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. Indicus|evm.model.CM009503.1.107 Q6S8J7 POTEA_HUMAN 60.417 0.0651872 1.44779 POTEA - POTE ankyrin domain family member A - Homo sapiens (Human) - POTEA gene Indicus|evm.model.CM009503.1.109 Q9UPS8 ANR26_HUMAN 61.538 0.941176 0.0596491 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.110 Q9UPS8 ANR26_HUMAN 71.553 0.998824 0.994152 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.111 O88967 YMEL1_MOUSE 94.266 0.997207 1.0014 Yme1l1 - ATP-dependent zinc metalloprotease YME1L1 - Mus musculus (Mouse) - Yme1l1 gene ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure (PubMed:17709429, PubMed:24616225, PubMed:26785494, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (By similarity). Required for normal, constitutive degradation of PRELID1 (PubMed:26785494). Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (By similarity). Indicus|evm.model.CM009503.1.112 E1BFR5 GWL_BOVIN 99.320 0.997732 0.998867 MASTL - Serine/threonine-protein kinase greatwall - Bos taurus (Bovine) - MASTL gene Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity). Indicus|evm.model.CM009503.1.113 P07106 ACBD5_BOVIN 97.186 0.992381 0.984991 ACBD5 - Acyl-CoA-binding domain-containing protein 5 - Bos taurus (Bovine) - ACBD5 gene Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity). Indicus|evm.model.CM009503.1.114 Q9QZM5 ABI1_RAT 98.529 0.995807 1.0021 Abi1 - Abl interactor 1 - Rattus norvegicus (Rat) - Abi1 gene May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. Indicus|evm.model.CM009503.1.115 Q33DR2 DPS1_MOUSE 86.141 0.875895 1.02445 Pdss1 - All trans-polyprenyl-diphosphate synthase PDSS1 - Mus musculus (Mouse) - Pdss1 gene Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699). Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively (PubMed:16262699). The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699). Indicus|evm.model.CM009503.1.117 Q7Z5R6 AB1IP_HUMAN 87.574 0.62069 1.21922 APBB1IP - Amyloid beta A4 precursor protein-binding family B member 1-interacting protein - Homo sapiens (Human) - APBB1IP gene Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. Indicus|evm.model.CM009503.1.118 Q8ND76 CCNY_HUMAN 99.303 0.993056 0.844575 CCNY - Cyclin-Y - Homo sapiens (Human) - CCNY gene Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. Indicus|evm.model.CM009503.1.120 P79145 CREM_CANLF 96.389 0.879902 1.13333 CREM - cAMP-responsive element modulator - Canis lupus familiaris (Dog) - CREM gene Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform Tau is a transcriptional activator. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity). Indicus|evm.model.CM009503.1.121 Q5RAK6 EST1A_PONAB 95.385 0.659794 0.068358 SMG6 - Telomerase-binding protein EST1A - Pongo abelii (Sumatran orangutan) - SMG6 gene Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). Indicus|evm.model.CM009503.1.122 Q5RCF3 CUL2_PONAB 99.597 0.997319 1.00134 CUL2 - Cullin-2 - Pongo abelii (Sumatran orangutan) - CUL2 gene Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (By similarity). Indicus|evm.model.CM009503.1.123 Q9D4H8 CUL2_MOUSE 100.000 0.475177 0.189262 Cul2 - Cullin-2 - Mus musculus (Mouse) - Cul2 gene Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (By similarity). Indicus|evm.model.CM009503.1.124 Q02372 NDUB8_BOVIN 100.000 0.982759 0.311828 NDUFB8 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor - Bos taurus (Bovine) - NDUFB8 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009503.1.125 Q8TEW0 PARD3_HUMAN 91.597 0.990868 0.969027 PARD3 - Partitioning defective 3 homolog - Homo sapiens (Human) - PARD3 gene Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). Indicus|evm.model.CM009503.1.126 Q8N335 GPD1L_HUMAN 77.778 0.315315 0.316239 GPD1L - Glycerol-3-phosphate dehydrogenase 1-like protein - Homo sapiens (Human) - GPD1L gene Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. Indicus|evm.model.CM009503.1.127 O14786 NRP1_HUMAN 95.125 0.997835 1.00108 NRP1 - Neuropilin-1 precursor - Homo sapiens (Human) - NRP1 gene Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:9288753, PubMed:9529250, PubMed:10688880). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:9288753, PubMed:9529250, PubMed:10688880, PubMed:19805273). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799). Indicus|evm.model.CM009503.1.129 P53712 ITB1_BOVIN 100.000 0.864425 1.15539 ITGB1 - Integrin beta-1 precursor - Bos taurus (Bovine) - ITGB1 gene Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). Indicus|evm.model.CM009503.1.130 Q9D541 CCDC7_MOUSE 52.522 0.207302 4.3558 Ccdc7 - Coiled-coil domain-containing protein 7 - Mus musculus (Mouse) - Ccdc7 gene May play a role in tumorigenesis. Indicus|evm.model.CM009503.1.131 Q9D4P0 ARL5B_MOUSE 100.000 0.983425 1.01117 Arl5b - ADP-ribosylation factor-like protein 5B - Mus musculus (Mouse) - Arl5b gene Binds and exchanges GTP and GDP. Indicus|evm.model.CM009503.1.132 Q5VYJ5 MALR1_HUMAN 59.182 0.944272 0.599258 MALRD1 - MAM and LDL-receptor class A domain-containing protein 1 precursor - Homo sapiens (Human) - MALRD1 gene Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis. Indicus|evm.model.CM009503.1.133 Q5VYJ5 MALR1_HUMAN 81.122 0.730337 0.12384 MALRD1 - MAM and LDL-receptor class A domain-containing protein 1 precursor - Homo sapiens (Human) - MALRD1 gene Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis. Indicus|evm.model.CM009503.1.135 Q6UX71 PXDC2_HUMAN 93.927 0.939048 0.992439 PLXDC2 - Plexin domain-containing protein 2 precursor - Homo sapiens (Human) - PLXDC2 gene May play a role in tumor angiogenesis. Indicus|evm.model.CM009503.1.136 O76041 NEBL_HUMAN 89.988 0.897106 0.920118 NEBL - Nebulette - Homo sapiens (Human) - NEBL gene Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). Isoform 2 might play a role in the assembly of focal adhesion (PubMed:15004028). Indicus|evm.model.CM009503.1.137 Q9DC07 LNEBL_MOUSE 100.000 0.797468 0.292593 Nebl - LIM zinc-binding domain-containing Nebulette - Mus musculus (Mouse) - Nebl gene Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion (By similarity). Indicus|evm.model.CM009503.1.138 Q1XH10 SKDA1_HUMAN 100.000 0.254197 0.459251 SKIDA1 - SKI/DACH domain-containing protein 1 - Homo sapiens (Human) - SKIDA1 gene Indicus|evm.model.CM009503.1.140 P55197 AF10_HUMAN 100.000 0.985075 0.250936 MLLT10 - Protein AF-10 - Homo sapiens (Human) - MLLT10 gene Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). Indicus|evm.model.CM009503.1.141 P55197 AF10_HUMAN 91.815 0.840361 0.310861 MLLT10 - Protein AF-10 - Homo sapiens (Human) - MLLT10 gene Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). Indicus|evm.model.CM009503.1.142 P55197 AF10_HUMAN 92.642 0.996219 0.495318 MLLT10 - Protein AF-10 - Homo sapiens (Human) - MLLT10 gene Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). Indicus|evm.model.CM009503.1.143 Q96KC8 DNJC1_HUMAN 75.862 0.493151 0.922383 DNAJC1 - DnaJ homolog subfamily C member 1 precursor - Homo sapiens (Human) - DNAJC1 gene May modulate protein synthesis. Indicus|evm.model.CM009503.1.144 Q96KC8 DNJC1_HUMAN 97.661 0.894737 0.34296 DNAJC1 - DnaJ homolog subfamily C member 1 precursor - Homo sapiens (Human) - DNAJC1 gene May modulate protein synthesis. Indicus|evm.model.CM009503.1.145 P82539 DNJC1_CANLF 95.000 0.202128 4.7 DNAJC1 - DnaJ homolog subfamily C member 1 - Canis lupus familiaris (Dog) - DNAJC1 gene Indicus|evm.model.CM009503.1.146 Q5E995 RS6_BOVIN 93.785 0.911917 0.7751 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009503.1.147 P62902 RL31_RAT 59.375 0.964706 0.68 Rpl31 - 60S ribosomal protein L31 - Rattus norvegicus (Rat) - Rpl31 gene cytosolic large ribosomal subunit, nucleolus, nucleoplasm, polysomal ribosome, synapse, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009503.1.148 Q32KX7 BMI1_BOVIN 100.000 0.993884 1.00307 BMI1 - Polycomb complex protein BMI-1 - Bos taurus (Bovine) - BMI1 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. Indicus|evm.model.CM009503.1.149 Q9JLI7 SPAG6_MOUSE 97.239 0.992157 1.00592 Spag6 - Sperm-associated antigen 6 - Mus musculus (Mouse) - Spag6 gene Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. Indicus|evm.model.CM009503.1.151 O13010 PI42A_PIG 92.593 0.644068 0.871921 PIP4K2A - Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha - Sus scrofa (Pig) - PIP4K2A gene Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (By similarity). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P (By similarity). Indicus|evm.model.CM009503.1.152 Q9R0I8 PI42A_RAT 97.959 0.417391 0.283251 Pip4k2a - Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha - Rattus norvegicus (Rat) - Pip4k2a gene Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (By similarity). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (PubMed:20204506). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (By similarity). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism. PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:21847559). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Indicus|evm.model.CM009503.1.153 Q5W041 ARMC3_HUMAN 86.384 0.971942 1.02179 ARMC3 - Armadillo repeat-containing protein 3 - Homo sapiens (Human) - ARMC3 gene extracellular exosome Indicus|evm.model.CM009503.1.154 Q9Y3D2 MSRB2_HUMAN 83.832 0.907104 1.00549 MSRB2 - Methionine-R-sulfoxide reductase B2, mitochondrial precursor - Homo sapiens (Human) - MSRB2 gene Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. Indicus|evm.model.CM009503.1.155 Q7RTS3 PTF1A_HUMAN 92.988 0.993884 0.996951 PTF1A - Pancreas transcription factor 1 subunit alpha - Homo sapiens (Human) - PTF1A gene Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. Indicus|evm.model.CM009503.1.156 Q8IYJ2 CJ067_HUMAN 61.240 0.969524 0.952813 C10orf67 - Uncharacterized protein C10orf67, mitochondrial precursor - Homo sapiens (Human) - C10orf67 gene Indicus|evm.model.CM009503.1.157 Q5VV17 OTUD1_HUMAN 95.175 0.799296 0.590437 OTUD1 - OTU domain-containing protein 1 - Homo sapiens (Human) - OTUD1 gene Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Indicus|evm.model.CM009503.1.158 Q5T5P2 SKT_HUMAN 79.215 0.998943 0.974267 KIAA1217 - Sickle tail protein homolog - Homo sapiens (Human) - KIAA1217 gene Required for normal development of intervertebral disks. Indicus|evm.model.CM009503.1.159 Q5T5U3 RHG21_HUMAN 86.223 0.998975 0.996936 ARHGAP21 - Rho GTPase-activating protein 21 - Homo sapiens (Human) - ARHGAP21 gene Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. Indicus|evm.model.CM009503.1.161 Q9NRG1 PRDC1_HUMAN 91.753 0.979592 0.435556 PRTFDC1 - Phosphoribosyltransferase domain-containing protein 1 - Homo sapiens (Human) - PRTFDC1 gene Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage. Indicus|evm.model.CM009503.1.162 Q8TC29 ENKUR_HUMAN 89.370 0.973077 1.01562 ENKUR - Enkurin - Homo sapiens (Human) - ENKUR gene Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. Indicus|evm.model.CM009503.1.163 Q9BH05 THNS1_MACFA 90.983 0.990654 1.00808 THNSL1 - Threonine synthase-like 1 - Macaca fascicularis (Crab-eating macaque) - THNSL1 gene Indicus|evm.model.CM009503.1.164 E1BBQ2 GP158_BOVIN 100.000 0.997517 0.993421 GPR158 - Probable G-protein coupled receptor 158 precursor - Bos taurus (Bovine) - GPR158 gene Orphan receptor. Indicus|evm.model.CM009503.1.165 Q8NEV4 MYO3A_HUMAN 79.951 0.998018 0.936881 MYO3A - Myosin-IIIa - Homo sapiens (Human) - MYO3A gene Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity). Indicus|evm.model.CM009503.1.166 P48321 DCE2_PIG 98.120 0.996587 1.00171 GAD2 - Glutamate decarboxylase 2 - Sus scrofa (Pig) - GAD2 gene Catalyzes the production of GABA. Indicus|evm.model.CM009503.1.167 Q9N0B3 CXD4_MACFA 55.814 0.970149 0.905405 GJD4 - Gap junction delta-4 protein - Macaca fascicularis (Crab-eating macaque) - GJD4 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009503.1.168 Q9H461 FZD8_HUMAN 98.667 0.440828 0.487032 FZD8 - Frizzled-8 precursor - Homo sapiens (Human) - FZD8 gene Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. Indicus|evm.model.CM009503.1.169 Q7YS99 OPTN_PIG 92.160 0.996516 1 OPTN - Optineurin - Sus scrofa (Pig) - OPTN gene Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. Indicus|evm.model.CM009503.1.170 Q7L590 MCM10_HUMAN 82.286 0.997704 0.995429 MCM10 - Protein MCM10 homolog - Homo sapiens (Human) - MCM10 gene Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). Indicus|evm.model.CM009503.1.171 Q8WVF2 UCMA_HUMAN 77.049 0.967742 0.898551 UCMA - Unique cartilage matrix-associated protein precursor - Homo sapiens (Human) - UCMA gene May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Indicus|evm.model.CM009503.1.172 O18778 PAHX_BOVIN 99.068 0.476969 1.99703 PHYH - Phytanoyl-CoA dioxygenase, peroxisomal precursor - Bos taurus (Bovine) - PHYH gene Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono- branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (By similarity). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl-and 4-methyl-branched acyl-CoAs (By similarity). Indicus|evm.model.CM009503.1.173 Q0VC82 SPS1_BOVIN 100.000 0.994911 1.00255 SEPHS1 - Selenide, water dikinase 1 - Bos taurus (Bovine) - SEPHS1 gene Synthesizes selenophosphate from selenide and ATP. Indicus|evm.model.CM009503.1.174 Q8N7W2 BEND7_HUMAN 90.582 0.986264 0.701349 BEND7 - BEN domain-containing protein 7 - Homo sapiens (Human) - BEND7 gene extracellular exosome Indicus|evm.model.CM009503.1.175 Q8N7W2 BEND7_HUMAN 91.837 0.695652 0.132948 BEND7 - BEN domain-containing protein 7 - Homo sapiens (Human) - BEND7 gene extracellular exosome Indicus|evm.model.CM009503.1.176 Q2HJ41 PRP18_BOVIN 100.000 0.994169 1.00292 PRPF18 - Pre-mRNA-splicing factor 18 - Bos taurus (Bovine) - PRPF18 gene Participates in the second step of pre-mRNA splicing. Indicus|evm.model.CM009503.1.177 Q9P2Q2 FRM4A_HUMAN 96.857 0.453836 0.740135 FRMD4A - FERM domain-containing protein 4A - Homo sapiens (Human) - FRMD4A gene Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). Indicus|evm.model.CM009503.1.178 Q2KI00 F107B_BOVIN 99.237 0.984848 1.00763 FAM107B - Protein FAM107B - Bos taurus (Bovine) - FAM107B gene Indicus|evm.model.CM009503.1.180 Q49AH0 CDNF_HUMAN 87.701 0.989362 1.00535 CDNF - Cerebral dopamine neurotrophic factor precursor - Homo sapiens (Human) - CDNF gene Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity). Indicus|evm.model.CM009503.1.181 Q2YDD0 HSP7E_BOVIN 100.000 0.685714 0.206287 HSPA14 - Heat shock 70 kDa protein 14 - Bos taurus (Bovine) - HSPA14 gene Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity). Indicus|evm.model.CM009503.1.182 Q2YDD0 HSP7E_BOVIN 99.544 0.555133 1.5501 HSPA14 - Heat shock 70 kDa protein 14 - Bos taurus (Bovine) - HSPA14 gene Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity). Indicus|evm.model.CM009503.1.183 Q32PH7 SUV92_BOVIN 100.000 0.995134 1.00244 SUV39H2 - Histone-lysine N-methyltransferase SUV39H2 - Bos taurus (Bovine) - SUV39H2 gene Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity). Indicus|evm.model.CM009503.1.184 Q5R6Z9 DCR1C_PONAB 83.407 0.943899 1.03035 DCLRE1C - Protein artemis - Pongo abelii (Sumatran orangutan) - DCLRE1C gene Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity). Indicus|evm.model.CM009503.1.185 Q32LI5 MEIG1_BOVIN 100.000 0.776786 1.27273 MEIG1 - Meiosis expressed gene 1 protein homolog - Bos taurus (Bovine) - MEIG1 gene Essential for spermiogenesis. Indicus|evm.model.CM009503.1.186 Q8R197 SAST_MOUSE 54.198 0.859532 1.1283 Olah - S-acyl fatty acid synthase thioesterase, medium chain - Mus musculus (Mouse) - Olah gene Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). Indicus|evm.model.CM009503.1.187 Q3SZF0 ACBD7_BOVIN 100.000 0.977528 1.01136 ACBD7 - Acyl-CoA-binding domain-containing protein 7 - Bos taurus (Bovine) - ACBD7 gene Binds medium- and long-chain acyl-CoA esters. Indicus|evm.model.CM009503.1.188 Q32LC1 RPP38_BOVIN 98.936 0.992933 1.00355 RPP38 - Ribonuclease P protein subunit p38 - Bos taurus (Bovine) - RPP38 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Indicus|evm.model.CM009503.1.189 Q9N181 NMT2_BOVIN 99.799 0.995992 1.00201 NMT2 - Glycylpeptide N-tetradecanoyltransferase 2 - Bos taurus (Bovine) - NMT2 gene Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Indicus|evm.model.CM009503.1.190 Q5VUB5 F1711_HUMAN 90.690 0.935414 1.04382 FAM171A1 - Protein FAM171A1 precursor - Homo sapiens (Human) - FAM171A1 gene Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. Indicus|evm.model.CM009503.1.192 P53708 ITA8_HUMAN 87.206 0.998039 0.959548 ITGA8 - Integrin alpha-8 precursor - Homo sapiens (Human) - ITGA8 gene Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Indicus|evm.model.CM009503.1.193 Q0IIH8 MINY3_BOVIN 100.000 0.995516 1.00225 MINDY3 - Ubiquitin carboxyl-terminal hydrolase MINDY-3 - Bos taurus (Bovine) - MINDY3 gene Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Indicus|evm.model.CM009503.1.195 A6QLJ8 PTER_BOVIN 100.000 0.994286 1.00287 PTER - Phosphotriesterase-related protein - Bos taurus (Bovine) - PTER gene Indicus|evm.model.CM009503.1.196 O88992 C1QRF_MOUSE 86.525 0.546875 0.992248 C1ql1 - C1q-related factor precursor - Mus musculus (Mouse) - C1ql1 gene May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Indicus|evm.model.CM009503.1.198 Q5E9C0 RSU1_BOVIN 100.000 0.904918 1.10108 RSU1 - Ras suppressor protein 1 - Bos taurus (Bovine) - RSU1 gene Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro (By similarity). Indicus|evm.model.CM009503.1.199 F1RWC3 CUBN_PIG 74.001 0.999412 0.938759 CUBN - Cubilin precursor - Sus scrofa (Pig) - CUBN gene Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. Indicus|evm.model.CM009503.1.200 Q7YS61 TRDMT_BOVIN 100.000 0.994898 1.00256 TRDMT1 - tRNA (cytosine(38)-C(5))-methyltransferase - Bos taurus (Bovine) - TRDMT1 gene Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Indicus|evm.model.CM009503.1.201 P48616 VIME_BOVIN 100.000 0.995717 1.00215 VIM - Vimentin - Bos taurus (Bovine) - VIM gene Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Indicus|evm.model.CM009503.1.202 P61648 SIA8F_PANTR 81.407 0.994987 1.00251 ST8SIA6 - Alpha-2,8-sialyltransferase 8F - Pan troglodytes (Chimpanzee) - ST8SIA6 gene Alpha-2,8-sialyltransferase that prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups. Indicus|evm.model.CM009503.1.203 Q9N1R5 HACD1_SHEEP 93.173 0.992 0.868056 HACD1 - Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 - Ovis aries (Sheep) - HACD1 gene Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Indicus|evm.model.CM009503.1.204 Q92783 STAM1_HUMAN 92.442 0.953271 0.990741 STAM - Signal transducing adapter molecule 1 - Homo sapiens (Human) - STAM gene Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Indicus|evm.model.CM009503.1.205 Q05005 TM236_RABIT 72.493 0.991453 1 TMEM236 - Transmembrane protein 236 - Oryctolagus cuniculus (Rabbit) - TMEM236 gene Indicus|evm.model.CM009503.1.206 P22897 MRC1_HUMAN 86.745 0.998626 1 MRC1 - Macrophage mannose receptor 1 precursor - Homo sapiens (Human) - MRC1 gene Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Indicus|evm.model.CM009503.1.207 Q08E40 S39AC_BOVIN 100.000 0.996947 1.00153 SLC39A12 - Zinc transporter ZIP12 - Bos taurus (Bovine) - SLC39A12 gene Acts as a zinc-influx transporter. Indicus|evm.model.CM009503.1.208 Q9MZL5 CACB2_BOVIN 99.661 0.893778 1.09287 CACNB2 - Voltage-dependent L-type calcium channel subunit beta-2 - Bos taurus (Bovine) - CACNB2 gene The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Indicus|evm.model.CM009503.1.209 Q8TEA1 NSUN6_HUMAN 86.567 0.993631 1.00426 NSUN6 - tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 - Homo sapiens (Human) - NSUN6 gene S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA) (PubMed:26160102, PubMed:27703015, PubMed:28531330). In vitro also methylates tRNA(Thr)(AGT) (PubMed:27703015, PubMed:26160102). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates (PubMed:26160102, PubMed:27703015). Indicus|evm.model.CM009503.1.210 Q9H2F5 EPC1_HUMAN 93.182 0.997543 0.973684 EPC1 - Enhancer of polycomb homolog 1 - Homo sapiens (Human) - EPC1 gene Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Indicus|evm.model.CM009503.1.211 P33176 KINH_HUMAN 98.339 0.997925 1.00104 KIF5B - Kinesin-1 heavy chain - Homo sapiens (Human) - KIF5B gene Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Indicus|evm.model.CM009503.1.212 Q8IWW6 RHG12_HUMAN 86.391 0.997481 0.938534 ARHGAP12 - Rho GTPase-activating protein 12 - Homo sapiens (Human) - ARHGAP12 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009503.1.213 P37275 ZEB1_HUMAN 91.115 0.87013 1.02758 ZEB1 - Zinc finger E-box-binding homeobox 1 - Homo sapiens (Human) - ZEB1 gene Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Indicus|evm.model.CM009503.1.214 Q7Z4V0 ZN438_HUMAN 57.674 0.950057 1.06401 ZNF438 - Zinc finger protein 438 - Homo sapiens (Human) - ZNF438 gene Isoform 1 acts as a transcriptional repressor. Indicus|evm.model.CM009503.1.215 O46385 SVIL_BOVIN 96.850 0.923472 0.798086 SVIL - Supervillin - Bos taurus (Bovine) - SVIL gene Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (By similarity). Indicus|evm.model.CM009503.1.219 A2VE02 JCAD_BOVIN 99.693 0.998469 1.00077 JCAD - Junctional protein associated with coronary artery disease homolog - Bos taurus (Bovine) - JCAD gene adherens junction, ruffle membrane, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Indicus|evm.model.CM009503.1.220 Q9NVV4 PAPD1_HUMAN 79.829 0.996575 1.00344 MTPAP - Poly(A) RNA polymerase, mitochondrial precursor - Homo sapiens (Human) - MTPAP gene Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. Indicus|evm.model.CM009503.1.221 P41279 M3K8_HUMAN 96.154 0.896353 1.11563 MAP3K8 - Mitogen-activated protein kinase kinase kinase 8 - Homo sapiens (Human) - MAP3K8 gene Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. Indicus|evm.model.CM009503.1.222 A0JNM6 LYZL1_BOVIN 100.000 0.986577 1.00676 LYZL1 - Lysozyme-like protein 1 precursor - Bos taurus (Bovine) - LYZL1 gene Indicus|evm.model.CM009503.1.223 Q8HYZ0 BAMBI_SHEEP 99.231 0.992337 1.00385 BAMBI - BMP and activin membrane-bound inhibitor homolog precursor - Ovis aries (Sheep) - BAMBI gene Negatively regulates TGF-beta signaling. Indicus|evm.model.CM009503.1.224 Q9BTA9 WAC_HUMAN 97.342 0.996678 0.930448 WAC - WW domain-containing adapter protein with coiled-coil - Homo sapiens (Human) - WAC gene Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). Indicus|evm.model.CM009503.1.225 A6QQZ7 MPP7_BOVIN 99.826 0.996534 1.00174 MPP7 - MAGUK p55 subfamily member 7 - Bos taurus (Bovine) - MPP7 gene Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity). Indicus|evm.model.CM009503.1.226 Q5T2S8 ODAD2_HUMAN 76.866 0.990899 0.841954 ODAD2 - Outer dynein arm-docking complex subunit 2 - Homo sapiens (Human) - ODAD2 gene Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule (By similarity). May be involved in a late step of axonemal outer dynein arm assembly (PubMed:23849778). Indicus|evm.model.CM009503.1.227 Q8IYA7 MKX_HUMAN 95.170 0.822014 1.21307 MKX - Homeobox protein Mohawk - Homo sapiens (Human) - MKX gene May act as a morphogenetic regulator of cell adhesion. Indicus|evm.model.CM009503.1.228 Q0IIG8 RAB18_BOVIN 100.000 0.87234 1.14078 RAB18 - Ras-related protein Rab-18 precursor - Bos taurus (Bovine) - RAB18 gene Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (By similarity). Indicus|evm.model.CM009503.1.231 Q9UPS8 ANR26_HUMAN 66.860 0.689076 0.139181 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009503.1.232 Q9GLR0 NEC2_BOVIN 97.872 0.989362 0.147335 PCSK2 - Neuroendocrine convertase 2 precursor - Bos taurus (Bovine) - PCSK2 gene Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). Indicus|evm.model.CM009503.1.233 Q9GLR0 NEC2_BOVIN 93.588 0.929032 0.971787 PCSK2 - Neuroendocrine convertase 2 precursor - Bos taurus (Bovine) - PCSK2 gene Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). Indicus|evm.model.CM009503.1.234 Q8N4L8 CCD24_HUMAN 68.889 0.794643 0.729642 CCDC24 - Coiled-coil domain-containing protein 24 - Homo sapiens (Human) - CCDC24 gene Indicus|evm.model.CM009503.1.235 P28572 SC6A9_RAT 82.381 0.776398 1.26176 Slc6a9 - Sodium- and chloride-dependent glycine transporter 1 - Rattus norvegicus (Rat) - Slc6a9 gene Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. Indicus|evm.model.CM009503.1.236 Q06002 BFSP1_BOVIN 99.868 0.997361 1.00132 BFSP1 - Filensin - Bos taurus (Bovine) - BFSP1 gene Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Involved in altering the calcium regulation of MIP water permeability (By similarity). Indicus|evm.model.CM009503.1.237 P60982 DEST_PIG 100.000 0.987952 1.00606 DSTN - Destrin - Sus scrofa (Pig) - DSTN gene Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. Indicus|evm.model.CM009503.1.238 Q9P2E9 RRBP1_HUMAN 81.463 0.387716 1.10851 RRBP1 - Ribosome-binding protein 1 - Homo sapiens (Human) - RRBP1 gene Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. Indicus|evm.model.CM009503.1.239 Q32PE7 BAFL_BOVIN 100.000 0.978022 1.01111 BANF2 - Barrier-to-autointegration factor-like protein - Bos taurus (Bovine) - BANF2 gene May play a role in BANF1 regulation and influence tissue-specific roles of BANF1. Indicus|evm.model.CM009503.1.240 Q3ZBM5 SNX5_BOVIN 99.752 0.995062 1.00248 SNX5 - Sorting nexin-5 - Bos taurus (Bovine) - SNX5 gene Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin. Plays a role in the internalization of EGFR after EGF stimulation. Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C and is retromer-independent. Together with PIP5K1C facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation. Plays a role in macropinocytosis (By similarity). Indicus|evm.model.CM009503.1.241 Q9BQP7 MGME1_HUMAN 80.882 0.988338 0.997093 MGME1 - Mitochondrial genome maintenance exonuclease 1 - Homo sapiens (Human) - MGME1 gene Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. Indicus|evm.model.CM009503.1.242 Q9BRP0 OVOL2_HUMAN 89.781 0.992727 1 OVOL2 - Transcription factor Ovo-like 2 - Homo sapiens (Human) - OVOL2 gene Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410). Important for the correct development of primordial germ cells in embryos (By similarity). Indicus|evm.model.CM009503.1.243 P0DJF2 PT117_MOUSE 88.889 0.97561 1.025 Pet117 - Protein PET117 homolog, mitochondrial precursor - Mus musculus (Mouse) - Pet117 gene mitochondrion, mitochondrial cytochrome c oxidase assembly Indicus|evm.model.CM009503.1.244 Q9H8E8 CSR2B_HUMAN 95.512 0.979367 0.929668 KAT14 - Cysteine-rich protein 2-binding protein - Homo sapiens (Human) - KAT14 gene Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. Indicus|evm.model.CM009503.1.245 Q9H8E8 CSR2B_HUMAN 96.610 0.479339 0.154731 KAT14 - Cysteine-rich protein 2-binding protein - Homo sapiens (Human) - KAT14 gene Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. Indicus|evm.model.CM009503.1.246 P52736 ZN133_HUMAN 83.439 0.957055 0.996942 ZNF133 - Zinc finger protein 133 - Homo sapiens (Human) - ZNF133 gene May be involved in transcriptional regulation as a repressor. Indicus|evm.model.CM009503.1.247 Q9NVP4 DZAN1_HUMAN 60.227 0.842697 0.236702 DZANK1 - Double zinc ribbon and ankyrin repeat-containing protein 1 - Homo sapiens (Human) - DZANK1 gene Indicus|evm.model.CM009503.1.248 P52736 ZN133_HUMAN 78.662 0.957055 0.996942 ZNF133 - Zinc finger protein 133 - Homo sapiens (Human) - ZNF133 gene May be involved in transcriptional regulation as a repressor. Indicus|evm.model.CM009503.1.249 Q9NVP4 DZAN1_HUMAN 71.863 0.99169 0.960106 DZANK1 - Double zinc ribbon and ankyrin repeat-containing protein 1 - Homo sapiens (Human) - DZANK1 gene Indicus|evm.model.CM009503.1.250 Q2T9S3 RPC6_BOVIN 99.684 0.993691 1.00316 POLR3F - DNA-directed RNA polymerase III subunit RPC6 - Bos taurus (Bovine) - POLR3F gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Preferentially binds double-stranded DNA (dsDNA) (By similarity). Indicus|evm.model.CM009503.1.251 O88851 RBBP9_MOUSE 91.954 0.988571 0.94086 Rbbp9 - Putative hydrolase RBBP9 - Mus musculus (Mouse) - Rbbp9 gene Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. Indicus|evm.model.CM009503.1.252 Q3SZN2 SC23B_BOVIN 100.000 0.997396 1.0013 SEC23B - Protein transport protein Sec23B - Bos taurus (Bovine) - SEC23B gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Indicus|evm.model.CM009503.1.253 A0A096LP01 SIM26_HUMAN 59.551 0.884211 1 SMIM26 - Small integral membrane protein 26 - Homo sapiens (Human) - SMIM26 gene Indicus|evm.model.CM009503.1.254 Q2T9V8 DTD1_BOVIN 100.000 0.557471 1.66507 DTD1 - D-aminoacyl-tRNA deacylase 1 - Bos taurus (Bovine) - DTD1 gene An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. Indicus|evm.model.CM009503.1.255 Q58DW5 RL5_BOVIN 98.653 0.993289 1.00337 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Indicus|evm.model.CM009503.1.256 Q2TBS3 SCP2D_BOVIN 100.000 0.824468 1.20513 SCP2D1 - SCP2 sterol-binding domain-containing protein 1 - Bos taurus (Bovine) - SCP2D1 gene sterol binding, phospholipid transport, positive regulation of intracellular cholesterol transport, steroid biosynthetic process Indicus|evm.model.CM009503.1.257 Q9HC58 NCKX3_HUMAN 93.035 0.995033 0.937888 SLC24A3 - Sodium/potassium/calcium exchanger 3 precursor - Homo sapiens (Human) - SLC24A3 gene Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Indicus|evm.model.CM009503.1.258 Q86XZ4 SPAS2_HUMAN 84.697 0.994737 0.697248 SPATS2 - Spermatogenesis-associated serine-rich protein 2 - Homo sapiens (Human) - SPATS2 gene cytoplasm, cytosol, RNA binding Indicus|evm.model.CM009503.1.260 Q8WYP3 RIN2_HUMAN 95.130 0.371671 0.922905 RIN2 - Ras and Rab interactor 2 - Homo sapiens (Human) - RIN2 gene Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. Indicus|evm.model.CM009503.1.261 P61600 NAA20_MOUSE 100.000 0.988827 1.00562 Naa20 - N-alpha-acetyltransferase 20 - Mus musculus (Mouse) - Naa20 gene Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration. Indicus|evm.model.CM009503.1.262 P63155 CRNL1_RAT 94.193 0.986014 1.03623 Crnkl1 - Crooked neck-like protein 1 - Rattus norvegicus (Rat) - Crnkl1 gene Involved in pre-mRNA splicing process. Indicus|evm.model.CM009503.1.263 Q8NHU2 CFA61_HUMAN 76.929 0.998332 0.969281 CFAP61 - Cilia- and flagella-associated protein 61 - Homo sapiens (Human) - CFAP61 gene May regulate cilium motility through its role in the assembly of the axonemal radial spokes. Indicus|evm.model.CM009503.1.264 A6H7J1 INSM1_BOVIN 99.671 0.977419 0.59387 INSM1 - Insulinoma-associated protein 1 - Bos taurus (Bovine) - INSM1 gene Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4'. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation. Indicus|evm.model.CM009503.1.265 Q2PPJ7 RGPA2_HUMAN 86.508 0.983511 1.00374 RALGAPA2 - Ral GTPase-activating protein subunit alpha-2 - Homo sapiens (Human) - RALGAPA2 gene Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. Indicus|evm.model.CM009503.1.266 B2RUJ5 APBA1_MOUSE 87.179 0.463415 0.0973872 Apba1 - Amyloid-beta A4 precursor protein-binding family A member 1 - Mus musculus (Mouse) - Apba1 gene Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity). Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). Indicus|evm.model.CM009503.1.267 A0JNH1 KIZ_BOVIN 93.810 0.997101 0.949106 KIZ - Centrosomal protein kizuna - Bos taurus (Bovine) - KIZ gene Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole (By similarity). Indicus|evm.model.CM009503.1.268 Q9H0D6 XRN2_HUMAN 95.794 0.997899 1.00211 XRN2 - 5'-3' exoribonuclease 2 - Homo sapiens (Human) - XRN2 gene Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). Indicus|evm.model.CM009503.1.269 Q9EQM3 NKX24_MOUSE 86.911 0.989247 0.525424 Nkx2-4 - Homeobox protein Nkx-2.4 - Mus musculus (Mouse) - Nkx2-4 gene Probable transcription factor. Indicus|evm.model.CM009503.1.270 O95096 NKX22_HUMAN 98.168 0.992701 1.00366 NKX2-2 - Homeobox protein Nkx-2.2 - Homo sapiens (Human) - NKX2-2 gene Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). Indicus|evm.model.CM009503.1.271 A6H767 NP1L1_BOVIN 96.447 0.994937 1.01023 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009503.1.272 P15863 PAX1_HUMAN 93.452 0.890957 0.70412 PAX1 - Paired box protein Pax-1 - Homo sapiens (Human) - PAX1 gene This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity). Indicus|evm.model.CM009503.1.273 Q3U2K5 KDM4D_MOUSE 56.338 0.311881 0.396078 Kdm4d - Lysine-specific demethylase 4D - Mus musculus (Mouse) - Kdm4d gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Indicus|evm.model.CM009503.1.274 Q9Y261 FOXA2_HUMAN 97.442 0.99536 0.943107 FOXA2 - Hepatocyte nuclear factor 3-beta - Homo sapiens (Human) - FOXA2 gene Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Indicus|evm.model.CM009503.1.275 P06579 TRBM_BOVIN 99.432 0.606218 1.6264 THBD - Thrombomodulin - Bos taurus (Bovine) - THBD gene Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Indicus|evm.model.CM009503.1.276 Q9NPY3 C1QR1_HUMAN 68.043 0.996918 0.995399 CD93 - Complement component C1q receptor precursor - Homo sapiens (Human) - CD93 gene Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Indicus|evm.model.CM009503.1.277 Q5E983 EF1B_BOVIN 97.101 0.951389 0.64 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Indicus|evm.model.CM009503.1.278 Q2KIW0 NXT1_BOVIN 99.286 0.874214 1.13571 NXT1 - NTF2-related export protein 1 - Bos taurus (Bovine) - NXT1 gene Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (By similarity). Indicus|evm.model.CM009503.1.279 Q9H116 GZF1_HUMAN 82.011 0.912031 1.0872 GZF1 - GDNF-inducible zinc finger protein 1 - Homo sapiens (Human) - GZF1 gene Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. Indicus|evm.model.CM009503.1.280 P81126 SNAB_BOVIN 100.000 0.993311 1.00336 NAPB - Beta-soluble NSF attachment protein - Bos taurus (Bovine) - NAPB gene Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Indicus|evm.model.CM009503.1.281 Q80Y72 CSTL1_MOUSE 59.821 0.808824 0.971429 Cstl1 - Cystatin-like 1 precursor - Mus musculus (Mouse) - Cstl1 gene Indicus|evm.model.CM009503.1.282 Q8K5A3 CST11_RAT 53.153 0.714286 1.10791 Cst11 - Cystatin-11 precursor - Rattus norvegicus (Rat) - Cst11 gene Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Indicus|evm.model.CM009503.1.283 Q32KQ9 CST16_BOVIN 99.206 0.984252 1.00794 Probable cystatin-16 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.284 Q2NKZ5 CST15_BOVIN 100.000 0.984496 1.00781 Probable cystatin-15 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.285 O60676 CST8_HUMAN 54.815 0.917808 1.02817 CST8 - Cystatin-8 precursor - Homo sapiens (Human) - CST8 gene Performs a specialized role during sperm development and maturation. Indicus|evm.model.CM009503.1.286 Q80ZN5 CST13_MOUSE 59.574 0.985915 1.00709 Cst13 - Cystatin-13 precursor - Mus musculus (Mouse) - Cst13 gene May perform a specialized role during sperm development and maturation. Indicus|evm.model.CM009503.1.287 Q29RH0 CST9_BOVIN 99.346 0.980645 1.01307 CST9 - Cystatin-9 precursor - Bos taurus (Bovine) - CST9 gene May play a role in hematopoietic differentiation or inflammation. Indicus|evm.model.CM009503.1.288 P01035 CYTC_BOVIN 100.000 0.986577 1.00676 CST3 - Cystatin-C precursor - Bos taurus (Bovine) - CST3 gene This is a thiol proteinase inhibitor. Indicus|evm.model.CM009503.1.290 Q08DM6 SYNG1_BOVIN 100.000 0.992278 1.00388 SYNDIG1 - Synapse differentiation-inducing gene protein 1 - Bos taurus (Bovine) - SYNDIG1 gene May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation. Indicus|evm.model.CM009503.1.291 O76096 CYTF_HUMAN 71.034 0.986301 1.0069 CST7 - Cystatin-F precursor - Homo sapiens (Human) - CST7 gene Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. Indicus|evm.model.CM009503.1.292 Q3T0E5 APMAP_BOVIN 100.000 0.995157 1.00243 APMAP - Adipocyte plasma membrane-associated protein - Bos taurus (Bovine) - APMAP gene Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation (By similarity). Indicus|evm.model.CM009503.1.293 Q9NUB1 ACS2L_HUMAN 86.998 0.891117 1.01306 ACSS1 - Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor - Homo sapiens (Human) - ACSS1 gene Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity). Indicus|evm.model.CM009503.1.294 Q9GMA3 VSX1_BOVIN 99.452 0.994536 1.00274 VSX1 - Visual system homeobox 1 - Bos taurus (Bovine) - VSX1 gene Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (By similarity). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity). Indicus|evm.model.CM009503.1.296 Q3U0P5 ENTP6_MOUSE 58.333 0.973684 0.334066 Entpd6 - Ectonucleoside triphosphate diphosphohydrolase 6 - Mus musculus (Mouse) - Entpd6 gene Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP. The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Indicus|evm.model.CM009503.1.297 Q5MIB6 PYGB_SHEEP 82.524 0.703448 0.172005 PYGB - Glycogen phosphorylase, brain form - Ovis aries (Sheep) - PYGB gene Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Indicus|evm.model.CM009503.1.298 Q3B7M9 PYGB_BOVIN 99.850 0.928671 0.848161 PYGB - Glycogen phosphorylase, brain form - Bos taurus (Bovine) - PYGB gene Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Indicus|evm.model.CM009503.1.299 Q08DW9 ABD12_BOVIN 99.704 0.976744 0.864322 ABHD12 - Lysophosphatidylserine lipase ABHD12 - Bos taurus (Bovine) - ABHD12 gene Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity). Indicus|evm.model.CM009503.1.300 Q6P6B7 ANR16_HUMAN 83.149 0.97043 1.03047 ANKRD16 - Ankyrin repeat domain-containing protein 16 - Homo sapiens (Human) - ANKRD16 gene Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. Indicus|evm.model.CM009503.1.301 O46563 VATH_BOVIN 92.708 0.995708 0.964803 ATP6V1H - V-type proton ATPase subunit H - Bos taurus (Bovine) - ATP6V1H gene Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity). Indicus|evm.model.CM009503.1.302 Q5RCP8 H2B2E_PONAB 90.991 0.452675 1.92857 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009503.1.303 P50397 GDIB_BOVIN 100.000 0.995516 1.00225 GDI2 - Rab GDP dissociation inhibitor beta - Bos taurus (Bovine) - GDI2 gene Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Indicus|evm.model.CM009503.1.304 Q5VWN6 TASO2_HUMAN 59.232 0.909886 1.0823 TASOR2 - Protein TASOR 2 - Homo sapiens (Human) - TASOR2 gene cytosol, nucleoplasm Indicus|evm.model.CM009503.1.305 Q8VBX0 ASB13_MOUSE 92.806 0.992832 1.0036 Asb13 - Ankyrin repeat and SOCS box protein 13 - Mus musculus (Mouse) - Asb13 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009503.1.306 Q5U206 CALL3_RAT 61.345 0.728395 1.08725 Calml3 - Calmodulin-like protein 3 - Rattus norvegicus (Rat) - Calml3 gene May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity). Indicus|evm.model.CM009503.1.307 P24044 CALM_PLAFA 58.219 0.966443 1 Calmodulin - Plasmodium falciparum Indicus|evm.model.CM009503.1.308 Q9Z206 ARHG8_MOUSE 83.789 0.94041 0.902521 Net1 - Neuroepithelial cell-transforming gene 1 protein - Mus musculus (Mouse) - Net1 gene Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway. Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. Indicus|evm.model.CM009503.1.309 Q1RMJ9 UCN3_BOVIN 98.795 0.988024 1.00602 UCN3 - Urocortin-3 precursor - Bos taurus (Bovine) - UCN3 gene Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity). Indicus|evm.model.CM009503.1.310 A6NHL2 TBAL3_HUMAN 79.775 0.96732 1.02915 TUBAL3 - Tubulin alpha chain-like 3 - Homo sapiens (Human) - TUBAL3 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Indicus|evm.model.CM009503.1.311 P52898 DDBX_BOVIN 82.663 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.312 P52898 DDBX_BOVIN 83.591 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.313 P52898 DDBX_BOVIN 87.307 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.314 P52898 DDBX_BOVIN 84.520 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.315 P52898 DDBX_BOVIN 79.286 0.262264 1.64087 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.316 P52897 PGFS2_BOVIN 70.166 0.767857 0.693498 Prostaglandin F synthase 2 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.317 P52898 DDBX_BOVIN 88.854 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.318 P52898 DDBX_BOVIN 100.000 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.319 P52898 DDBX_BOVIN 89.783 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.320 P52898 DDBX_BOVIN 89.506 0.987768 1.01238 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.321 P52897 PGFS2_BOVIN 99.690 0.993827 1.0031 Prostaglandin F synthase 2 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.322 P52898 DDBX_BOVIN 85.185 0.870588 1.05263 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.323 P52898 DDBX_BOVIN 88.710 0.516722 1.85139 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.324 P82125 AKCL2_PIG 83.775 0.993266 0.986711 AKR1E2 - 1,5-anhydro-D-fructose reductase - Sus scrofa (Pig) - AKR1E2 gene Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Indicus|evm.model.CM009503.1.325 Q9DB27 MCTS1_MOUSE 96.133 0.989011 1.00552 Mcts1 - Malignant T-cell-amplified sequence 1 - Mus musculus (Mouse) - Mcts1 gene Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3 (By similarity). Indicus|evm.model.CM009503.1.329 Q99612 KLF6_HUMAN 93.310 0.887147 1.12721 KLF6 - Krueppel-like factor 6 - Homo sapiens (Human) - KLF6 gene Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development. Indicus|evm.model.CM009503.1.332 Q5JRX3 PREP_HUMAN 81.581 0.996128 0.996143 PITRM1 - Presequence protease, mitochondrial precursor - Homo sapiens (Human) - PITRM1 gene Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469). Has an ATP-independent activity (PubMed:16849325). Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155). Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469). Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155). Also degrades other unstructured peptides (PubMed:19196155). It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469). It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469). Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469). Indicus|evm.model.CM009503.1.333 P47859 PFKAP_RABIT 89.796 0.987374 1.00126 PFKP - ATP-dependent 6-phosphofructokinase, platelet type - Oryctolagus cuniculus (Rabbit) - PFKP gene Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Indicus|evm.model.CM009503.1.336 P24049 RL17_RAT 95.109 0.989189 1.00543 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009503.1.340 P52898 DDBX_BOVIN 87.857 0.701005 1.2322 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.341 Q9NS39 RED2_HUMAN 79.066 0.945946 1.00135 ADARB2 - Double-stranded RNA-specific editase B2 - Homo sapiens (Human) - ADARB2 gene Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA. Indicus|evm.model.CM009503.1.343 Q5R650 WDR37_PONAB 95.556 0.995968 1.00202 WDR37 - WD repeat-containing protein 37 - Pongo abelii (Sumatran orangutan) - WDR37 gene cytoplasm, nucleus Indicus|evm.model.CM009503.1.345 Q1LZ95 IDI1_BOVIN 100.000 0.784722 1.26872 IDI1 - Isopentenyl-diphosphate Delta-isomerase 1 - Bos taurus (Bovine) - IDI1 gene Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Indicus|evm.model.CM009503.1.346 Q9BZE4 NOG1_HUMAN 93.691 0.99685 1.00158 GTPBP4 - GTP-binding protein 4 - Homo sapiens (Human) - GTPBP4 gene Involved in the biogenesis of the 60S ribosomal subunit. Indicus|evm.model.CM009503.1.347 Q92615 LAR4B_HUMAN 80.980 0.411091 2.24797 LARP4B - La-related protein 4B - Homo sapiens (Human) - LARP4B gene Stimulates mRNA translation. Indicus|evm.model.CM009503.1.349 Q9Y2E4 DIP2C_HUMAN 98.470 0.907005 1.06427 DIP2C - Disco-interacting protein 2 homolog C - Homo sapiens (Human) - DIP2C gene Indicus|evm.model.CM009503.1.350 Q15326 ZMY11_HUMAN 99.003 0.996683 1.00166 ZMYND11 - Zinc finger MYND domain-containing protein 11 - Homo sapiens (Human) - ZMYND11 gene Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. Indicus|evm.model.CM009503.1.352 P10279 PRIO_BOVIN 100.000 0.992453 1.00379 PRNP - Major prion protein precursor - Bos taurus (Bovine) - PRNP gene Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). Indicus|evm.model.CM009503.1.353 Q9GK16 PRND_BOVIN 99.438 0.988827 1.00562 PRND - Prion-like protein doppel precursor - Bos taurus (Bovine) - PRND gene Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Indicus|evm.model.CM009503.1.354 P50749 RASF2_HUMAN 95.399 0.993884 1.00307 RASSF2 - Ras association domain-containing protein 2 - Homo sapiens (Human) - RASSF2 gene Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. Indicus|evm.model.CM009503.1.355 Q9UGH3 S23A2_HUMAN 98.116 0.995305 0.983077 SLC23A2 - Solute carrier family 23 member 2 - Homo sapiens (Human) - SLC23A2 gene Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. Indicus|evm.model.CM009503.1.356 Q5E975 TM230_BOVIN 100.000 0.983471 1.00833 TMEM230 - Transmembrane protein 230 - Bos taurus (Bovine) - TMEM230 gene Involved in trafficking and recycling of synaptic vesicles. Indicus|evm.model.CM009503.1.357 Q3ZBW4 PCNA_BOVIN 100.000 0.992366 1.00383 PCNA - Proliferating cell nuclear antigen - Bos taurus (Bovine) - PCNA gene Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity). Indicus|evm.model.CM009503.1.359 A0JNC1 CDS2_BOVIN 98.169 0.960352 1.02022 CDS2 - Phosphatidate cytidylyltransferase 2 - Bos taurus (Bovine) - CDS2 gene Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (By similarity). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (By similarity). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (By similarity). Indicus|evm.model.CM009503.1.360 Q2MHN1 FRIL_FELCA 63.953 0.94382 0.508571 FTL - Ferritin light chain - Felis catus (Cat) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009503.1.361 Q3T0Q2 TMM59_BOVIN 96.732 0.678571 0.693498 TMEM59 - Transmembrane protein 59 precursor - Bos taurus (Bovine) - TMEM59 gene Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. Indicus|evm.model.CM009503.1.362 Q8SPN1 PKR2_BOVIN 99.740 0.994805 1.0026 PROKR2 - Prokineticin receptor 2 - Bos taurus (Bovine) - PROKR2 gene Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity). Indicus|evm.model.CM009503.1.364 Q9NPB8 GPCP1_HUMAN 97.619 0.997028 1.00149 GPCPD1 - Glycerophosphocholine phosphodiesterase GPCPD1 - Homo sapiens (Human) - GPCPD1 gene May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity. Indicus|evm.model.CM009503.1.365 O00303 EIF3F_HUMAN 93.269 0.990244 0.57423 EIF3F - Eukaryotic translation initiation factor 3 subunit F - Homo sapiens (Human) - EIF3F gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Indicus|evm.model.CM009503.1.366 Q9DCH4 EIF3F_MOUSE 97.222 0.294118 0.32964 Eif3f - Eukaryotic translation initiation factor 3 subunit F - Mus musculus (Mouse) - Eif3f gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Indicus|evm.model.CM009503.1.367 Q2KIJ1 SHLD1_BOVIN 100.000 0.990338 1.00485 SHLD1 - Shieldin complex subunit 1 - Bos taurus (Bovine) - SHLD1 gene Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. Indicus|evm.model.CM009503.1.368 P23389 SCG1_BOVIN 99.381 0.996909 1.00155 CHGB - Secretogranin-1 precursor - Bos taurus (Bovine) - CHGB gene Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites. Indicus|evm.model.CM009503.1.369 Q2T9V5 TRM6_BOVIN 99.799 0.995984 1.00201 TRMT6 - tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 - Bos taurus (Bovine) - TRMT6 gene Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. Indicus|evm.model.CM009503.1.370 E1BPX4 MCM8_BOVIN 98.077 0.997599 1.02083 MCM8 - DNA helicase MCM8 - Bos taurus (Bovine) - MCM8 gene Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Probably by regulating HR, plays a key role during gametogenesis. Stabilizes MCM9 protein. Indicus|evm.model.CM009503.1.371 Q9UJA2 CRLS1_HUMAN 88.333 0.986799 1.00664 CRLS1 - Cardiolipin synthase (CMP-forming) - Homo sapiens (Human) - CRLS1 gene Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. Indicus|evm.model.CM009503.1.372 Q8WUT4 LRRN4_HUMAN 67.995 0.963758 1.00676 LRRN4 - Leucine-rich repeat neuronal protein 4 precursor - Homo sapiens (Human) - LRRN4 gene May play an important role in hippocampus-dependent long-lasting memory. Indicus|evm.model.CM009503.1.373 Q9BQL6 FERM1_HUMAN 91.728 0.99705 1.00148 FERMT1 - Fermitin family homolog 1 - Homo sapiens (Human) - FERMT1 gene Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. Indicus|evm.model.CM009503.1.376 O19006 BMP2_DAMDA 97.727 0.994949 1 BMP2 - Bone morphogenetic protein 2 precursor - Dama dama (Fallow deer) - BMP2 gene Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Indicus|evm.model.CM009503.1.377 P61078 UB2D3_RAT 96.599 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009503.1.378 Q3ZCF7 UB2D3_BOVIN 88.462 0.662338 0.52381 UBE2D3 - Ubiquitin-conjugating enzyme E2 D3 - Bos taurus (Bovine) - UBE2D3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009503.1.379 P61078 UB2D3_RAT 88.435 0.985401 0.931973 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009503.1.380 P61078 UB2D3_RAT 96.599 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009503.1.381 P61078 UB2D3_RAT 96.599 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009503.1.382 P61078 UB2D3_RAT 96.599 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009503.1.383 P61078 UB2D3_RAT 97.279 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009503.1.384 P61078 UB2D3_RAT 96.599 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009503.1.386 Q01580 HBEGF_PIG 82.759 0.761062 0.543269 HBEGF - Proheparin-binding EGF-like growth factor precursor - Sus scrofa (Pig) - HBEGF gene Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). Indicus|evm.model.CM009503.1.387 Q9UJM8 HAOX1_HUMAN 92.432 0.994609 1.0027 HAO1 - Hydroxyacid oxidase 1 - Homo sapiens (Human) - HAO1 gene Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. Indicus|evm.model.CM009503.1.389 Q9TTM9 ADA1D_PIG 82.261 0.996479 0.994746 ADRA1D - Alpha-1D adrenergic receptor - Sus scrofa (Pig) - ADRA1D gene This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Indicus|evm.model.CM009503.1.390 Q9NWM0 SMOX_HUMAN 91.282 0.996587 1.05586 SMOX - Spermine oxidase - Homo sapiens (Human) - SMOX gene Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. Indicus|evm.model.CM009503.1.391 Q9Y225 RNF24_HUMAN 89.865 0.985185 0.912162 RNF24 - RING finger protein 24 - Homo sapiens (Human) - RNF24 gene May play a role in TRPCs intracellular trafficking. Indicus|evm.model.CM009503.1.392 Q9BZ23 PANK2_HUMAN 94.286 0.995614 0.8 PANK2 - Pantothenate kinase 2, mitochondrial precursor - Homo sapiens (Human) - PANK2 gene Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:17825826, PubMed:17242360, PubMed:16272150). Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC) (PubMed:30221726). Indicus|evm.model.CM009503.1.394 Q7Z434 MAVS_HUMAN 57.143 0.975472 0.981481 MAVS - Mitochondrial antiviral-signaling protein - Homo sapiens (Human) - MAVS gene Required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:20127681, PubMed:21170385). Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:25636800, PubMed:20127681, PubMed:21170385, PubMed:20628368). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Indicus|evm.model.CM009503.1.395 Q9NUS5 AP5S1_HUMAN 82.412 0.9801 1.005 AP5S1 - AP-5 complex subunit sigma-1 - Homo sapiens (Human) - AP5S1 gene As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair. Indicus|evm.model.CM009503.1.396 P30305 MPIP2_HUMAN 86.403 0.996522 0.991379 CDC25B - M-phase inducer phosphatase 2 - Homo sapiens (Human) - CDC25B gene Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. Indicus|evm.model.CM009503.1.397 P07199 CENPB_HUMAN 96.883 0.626427 1.02337 CENPB - Major centromere autoantigen B - Homo sapiens (Human) - CENPB gene Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). Indicus|evm.model.CM009503.1.398 Q58DA1 SPEF1_BOVIN 100.000 0.991561 1.00424 SPEF1 - Sperm flagellar protein 1 - Bos taurus (Bovine) - SPEF1 gene Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (By similarity). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (By similarity). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity). Indicus|evm.model.CM009503.1.400 Q2KIM1 CT027_BOVIN 100.000 0.988571 1.00575 UPF0687 protein C20orf27 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.401 Q96MM6 HS12B_HUMAN 94.461 0.997089 1.00146 HSPA12B - Heat shock 70 kDa protein 12B - Homo sapiens (Human) - HSPA12B gene Indicus|evm.model.CM009503.1.403 A7LCJ3 SN_PIG 81.686 0.998833 0.990751 SIGLEC1 - Sialoadhesin precursor - Sus scrofa (Pig) - SIGLEC1 gene Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis (By similarity). Acts as an endocytic receptor mediating clathrin dependent endocytosis. In case of porcine reproductive and respiratory syndrome virus (PRRSV), mediates virion attachment and internalization into alveolar macrophages through a clathrin-coated dependent process. Indicus|evm.model.CM009503.1.404 Q9BZ11 ADA33_HUMAN 76.222 0.881119 1.05535 ADAM33 - Disintegrin and metalloproteinase domain-containing protein 33 precursor - Homo sapiens (Human) - ADAM33 gene integral component of membrane, metalloendopeptidase activity, zinc ion binding, proteolysis Indicus|evm.model.CM009503.1.407 O75882 ATRN_HUMAN 93.310 0.983757 0.990903 ATRN - Attractin precursor - Homo sapiens (Human) - ATRN gene Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). Indicus|evm.model.CM009503.1.408 Q5TEA3 CT194_HUMAN 90.994 0.998302 1.00085 DNAAF9 - Dynein axonemal assembly factor 9 - Homo sapiens (Human) - DNAAF9 gene May act as an effector for ARL3. Indicus|evm.model.CM009503.1.409 Q8NBS3 S4A11_HUMAN 81.368 0.847475 1.11111 SLC4A11 - Sodium bicarbonate transporter-like protein 11 - Homo sapiens (Human) - SLC4A11 gene Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. Indicus|evm.model.CM009503.1.410 Q2KIC5 ITPA_BOVIN 100.000 0.990431 1.00481 ITPA - Inosine triphosphate pyrophosphatase - Bos taurus (Bovine) - ITPA gene Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Indicus|evm.model.CM009503.1.411 Q1LZB0 DDRGK_BOVIN 99.681 0.993631 1.00319 DDRGK1 - DDRGK domain-containing protein 1 precursor - Bos taurus (Bovine) - DDRGK1 gene Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy). In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets. Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (By similarity). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response (By similarity). Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (By similarity). Indicus|evm.model.CM009503.1.412 O60299 LZTS3_HUMAN 97.478 0.941094 1.05944 LZTS3 - Leucine zipper putative tumor suppressor 3 - Homo sapiens (Human) - LZTS3 gene May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. Indicus|evm.model.CM009503.1.413 Q95KD0 FAKD5_MACFA 79.739 0.934889 1.06545 FASTKD5 - FAST kinase domain-containing protein 5, mitochondrial precursor - Macaca fascicularis (Crab-eating macaque) - FASTKD5 gene Plays an important role in the processing of non-canonical mitochondrial mRNA precursors. Indicus|evm.model.CM009503.1.414 O94941 RNF37_HUMAN 87.985 0.996283 0.994455 UBOX5 - RING finger protein 37 - Homo sapiens (Human) - UBOX5 gene May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. Indicus|evm.model.CM009503.1.415 P01180 NEU2_BOVIN 100.000 0.357798 0.656627 AVP - Vasopressin-neurophysin 2-copeptin precursor - Bos taurus (Bovine) - AVP gene Neurophysin 2 specifically binds vasopressin. Indicus|evm.model.CM009503.1.416 P01175 NEU1_BOVIN 100.000 0.984127 1.008 OXT - Oxytocin-neurophysin 1 precursor - Bos taurus (Bovine) - OXT gene Neurophysin 1 specifically binds oxytocin. Indicus|evm.model.CM009503.1.417 Q3SZ86 RT26_BOVIN 99.512 0.990291 1.00488 MRPS26 - 28S ribosomal protein S26, mitochondrial precursor - Bos taurus (Bovine) - MRPS26 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009503.1.418 P18433 PTPRA_HUMAN 94.888 0.982609 1.00374 PTPRA - Receptor-type tyrosine-protein phosphatase alpha precursor - Homo sapiens (Human) - PTPRA gene Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). Indicus|evm.model.CM009503.1.419 Q5E9L7 VPS16_BOVIN 99.881 0.997619 1.00119 VPS16 - Vacuolar protein sorting-associated protein 16 homolog - Bos taurus (Bovine) - VPS16 gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for recruitment of VPS33A to the HOPS complex. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG. Indicus|evm.model.CM009503.1.420 Q9H1Q7 PED1A_HUMAN 88.767 0.857414 1.15859 PCED1A - PC-esterase domain-containing protein 1A - Homo sapiens (Human) - PCED1A gene Indicus|evm.model.CM009503.1.421 Q8WW34 TM239_HUMAN 85.256 0.547703 1.45128 TMEM239 - Transmembrane protein 239 - Homo sapiens (Human) - TMEM239 gene Indicus|evm.model.CM009503.1.422 Q96SM3 CPXM1_HUMAN 88.692 0.997264 0.995913 CPXM1 - Probable carboxypeptidase X1 precursor - Homo sapiens (Human) - CPXM1 gene May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity). Indicus|evm.model.CM009503.1.423 Q9BQW3 COE4_HUMAN 97.674 0.996683 1.00166 EBF4 - Transcription factor COE4 - Homo sapiens (Human) - EBF4 gene Transcriptional factor which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Indicus|evm.model.CM009503.1.424 O77784 IDH3B_BOVIN 100.000 0.994819 1.0026 IDH3B - Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor - Bos taurus (Bovine) - IDH3B gene Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Indicus|evm.model.CM009503.1.425 Q3SZ63 NOP56_BOVIN 99.497 0.99665 1.00168 NOP56 - Nucleolar protein 56 - Bos taurus (Bovine) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Indicus|evm.model.CM009503.1.426 Q8TDI7 TMC2_HUMAN 86.108 0.922374 0.966887 TMC2 - Transmembrane channel-like protein 2 - Homo sapiens (Human) - TMC2 gene Probable ion channel required for the normal function of cochlear hair cells (PubMed:11850618). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity). Indicus|evm.model.CM009503.1.427 Q58DW4 RSMB_BOVIN 100.000 0.991701 1.00417 SNRPB - Small nuclear ribonucleoprotein-associated protein B' - Bos taurus (Bovine) - SNRPB gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). Indicus|evm.model.CM009503.1.428 O95932 TGM3L_HUMAN 86.790 0.973684 1.02266 TGM6 - Protein-glutamine gamma-glutamyltransferase 6 - Homo sapiens (Human) - TGM6 gene Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Indicus|evm.model.CM009503.1.429 A6QP57 TGM3_BOVIN 99.566 0.99711 1.00145 TGM3 - Protein-glutamine gamma-glutamyltransferase E precursor - Bos taurus (Bovine) - TGM3 gene Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath (By similarity). Indicus|evm.model.CM009503.1.430 Q5R893 H2B1_PONAB 94.231 0.81746 1 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009503.1.431 A8D8X1 RL10_SHEEP 94.805 0.452381 0.785047 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009503.1.432 Q8TDR2 STK35_HUMAN 91.466 0.996296 1.01124 STK35 - Serine/threonine-protein kinase 35 - Homo sapiens (Human) - STK35 gene nuclear body, nucleoplasm, nucleus, protein kinase activity, protein serine/threonine kinase activity, meiotic cell cycle Indicus|evm.model.CM009503.1.433 Q95104 PDYN_BOVIN 99.612 0.992278 1.00388 PDYN - Proenkephalin-B precursor - Bos taurus (Bovine) - PDYN gene Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Indicus|evm.model.CM009503.1.434 O46631 SHPS1_BOVIN 97.233 0.864726 1.15415 SIRPA - Tyrosine-protein phosphatase non-receptor type substrate 1 precursor - Bos taurus (Bovine) - SIRPA gene Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Indicus|evm.model.CM009503.1.436 O46631 SHPS1_BOVIN 84.615 0.435811 0.58498 SIRPA - Tyrosine-protein phosphatase non-receptor type substrate 1 precursor - Bos taurus (Bovine) - SIRPA gene Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Indicus|evm.model.CM009503.1.437 Q9H0H5 RGAP1_HUMAN 90.698 0.107692 0.617089 RACGAP1 - Rac GTPase-activating protein 1 - Homo sapiens (Human) - RACGAP1 gene Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. Indicus|evm.model.CM009503.1.438 O46631 SHPS1_BOVIN 91.954 0.920424 0.745059 SIRPA - Tyrosine-protein phosphatase non-receptor type substrate 1 precursor - Bos taurus (Bovine) - SIRPA gene Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Indicus|evm.model.CM009503.1.439 B5DFK7 AB17C_RAT 54.506 0.815498 0.846875 Abhd17c - Alpha/beta hydrolase domain-containing protein 17C - Rattus norvegicus (Rat) - Abhd17c gene Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Indicus|evm.model.CM009503.1.440 P32244 MC3R_RAT 48.905 0.981132 0.328173 Mc3r - Melanocortin receptor 3 - Rattus norvegicus (Rat) - Mc3r gene Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. Indicus|evm.model.CM009503.1.441 P41968 MC3R_HUMAN 77.564 0.630081 0.76161 MC3R - Melanocortin receptor 3 - Homo sapiens (Human) - MC3R gene Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. Indicus|evm.model.CM009503.1.442 Q96MD7 CI085_HUMAN 94.545 0.703226 0.865922 C9orf85 - Uncharacterized protein C9orf85 - Homo sapiens (Human) - C9orf85 gene Indicus|evm.model.CM009503.1.443 A4IFH4 PSF1_BOVIN 100.000 0.989848 1.0051 GINS1 - DNA replication complex GINS protein PSF1 - Bos taurus (Bovine) - GINS1 gene Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. Indicus|evm.model.CM009503.1.444 Q58CZ2 PCMD2_BOVIN 99.723 0.902256 1.10526 PCMTD2 - Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 - Bos taurus (Bovine) - PCMTD2 gene cytoplasm, protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Indicus|evm.model.CM009503.1.445 Q01538 MYT1_HUMAN 86.756 0.954822 1.02676 MYT1 - Myelin transcription factor 1 - Homo sapiens (Human) - MYT1 gene Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. Indicus|evm.model.CM009503.1.446 Q8MJV2 NPBW2_BOVIN 98.000 0.880531 0.672619 NPBWR2 - Neuropeptides B/W receptor type 2 - Bos taurus (Bovine) - NPBWR2 gene Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity). Indicus|evm.model.CM009503.1.447 P41146 OPRX_HUMAN 94.324 0.726378 1.37297 OPRL1 - Nociceptin receptor - Homo sapiens (Human) - OPRL1 gene G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. Indicus|evm.model.CM009503.1.448 Q8TD35 LKAM1_HUMAN 76.684 0.835556 1.15979 LKAAEAR1 - Protein LKAAEAR1 - Homo sapiens (Human) - LKAAEAR1 gene Indicus|evm.model.CM009503.1.449 Q08DC7 RGS19_BOVIN 100.000 0.601626 1.65471 RGS19 - Regulator of G-protein signaling 19 - Bos taurus (Bovine) - RGS19 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (By similarity). Indicus|evm.model.CM009503.1.450 Q148K0 TCEA2_BOVIN 88.372 0.992958 0.946667 TCEA2 - Transcription elongation factor A protein 2 - Bos taurus (Bovine) - TCEA2 gene Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity). Indicus|evm.model.CM009503.1.451 P35713 SOX18_HUMAN 88.372 0.993377 0.786458 SOX18 - Transcription factor SOX-18 - Homo sapiens (Human) - SOX18 gene Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development. Indicus|evm.model.CM009503.1.452 A0A1B0GTL2 CT204_HUMAN 77.249 0.973958 1.01587 C20orf204 - Uncharacterized protein C20orf204 precursor - Homo sapiens (Human) - C20orf204 gene Indicus|evm.model.CM009503.1.453 Q2KJJ0 PRP6_BOVIN 100.000 0.997877 1.00106 PRPF6 - Pre-mRNA-processing factor 6 - Bos taurus (Bovine) - PRPF6 gene Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Indicus|evm.model.CM009503.1.454 Q9BYL1 SAM10_HUMAN 91.329 0.955556 0.891089 SAMD10 - Sterile alpha motif domain-containing protein 10 - Homo sapiens (Human) - SAMD10 gene Indicus|evm.model.CM009503.1.455 Q96KM6 Z512B_HUMAN 84.420 0.997788 1.01345 ZNF512B - Zinc finger protein 512B - Homo sapiens (Human) - ZNF512B gene May be involved in transcriptional regulation. Indicus|evm.model.CM009503.1.456 Q9NWZ5 UCKL1_HUMAN 94.364 0.996364 1.00365 UCKL1 - Uridine-cytidine kinase-like 1 - Homo sapiens (Human) - UCKL1 gene May contribute to UTP accumulation needed for blast transformation and proliferation. Indicus|evm.model.CM009503.1.457 Q29455 DNJC5_BOVIN 100.000 0.98995 1.00505 DNAJC5 - DnaJ homolog subfamily C member 5 - Bos taurus (Bovine) - DNAJC5 gene Acts as a general chaperone in regulated exocytosis (PubMed:9395474). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). Indicus|evm.model.CM009503.1.458 Q5RCT1 TPD54_PONAB 90.777 0.990338 1.00485 TPD52L2 - Tumor protein D54 - Pongo abelii (Sumatran orangutan) - TPD52L2 gene cytoplasm, perinuclear region of cytoplasm Indicus|evm.model.CM009503.1.459 Q9H3Z7 ABHGB_HUMAN 87.977 0.619308 1.17058 ABHD16B - Protein ABHD16B - Homo sapiens (Human) - ABHD16B gene membrane, nucleoplasm, acylglycerol lipase activity, palmitoyl-(protein) hydrolase activity, phospholipase activity, monoacylglycerol catabolic process, phosphatidylserine catabolic process Indicus|evm.model.CM009503.1.460 Q86UZ6 ZBT46_HUMAN 86.318 0.951456 1.04924 ZBTB46 - Zinc finger and BTB domain-containing protein 46 - Homo sapiens (Human) - ZBTB46 gene Functions as a transcriptional repressor for PRDM1. Indicus|evm.model.CM009503.1.461 Q9NR83 S2A4R_HUMAN 67.030 0.48951 1.84755 SLC2A4RG - SLC2A4 regulator - Homo sapiens (Human) - SLC2A4RG gene Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'. Indicus|evm.model.CM009503.1.462 Q17QX2 ZGPAT_BOVIN 99.805 0.996109 1.00195 ZGPAT - Zinc finger CCCH-type with G patch domain-containing protein - Bos taurus (Bovine) - ZGPAT gene Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity). Indicus|evm.model.CM009503.1.463 Q32LJ2 ARFRP_BOVIN 100.000 0.990099 1.00498 ARFRP1 - ADP-ribosylation factor-related protein 1 - Bos taurus (Bovine) - ARFRP1 gene Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Indicus|evm.model.CM009503.1.464 O95407 TNF6B_HUMAN 78.102 0.919192 0.99 TNFRSF6B - Tumor necrosis factor receptor superfamily member 6B precursor - Homo sapiens (Human) - TNFRSF6B gene Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Indicus|evm.model.CM009503.1.465 A4K436 RTEL1_BOVIN 100.000 0.606522 0.378289 RTEL1 - Regulator of telomere elongation helicase 1 - Bos taurus (Bovine) - RTEL1 gene ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. Indicus|evm.model.CM009503.1.466 A4K436 RTEL1_BOVIN 99.394 0.928571 0.4375 RTEL1 - Regulator of telomere elongation helicase 1 - Bos taurus (Bovine) - RTEL1 gene ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. Indicus|evm.model.CM009503.1.467 A4K436 RTEL1_BOVIN 99.138 0.646067 0.146382 RTEL1 - Regulator of telomere elongation helicase 1 - Bos taurus (Bovine) - RTEL1 gene ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. Indicus|evm.model.CM009503.1.468 A4IFK9 STMN3_BOVIN 100.000 0.98895 1.00556 STMN3 - Stathmin-3 - Bos taurus (Bovine) - STMN3 gene Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. Indicus|evm.model.CM009503.1.469 Q9UKD1 GMEB2_HUMAN 91.791 0.996276 1.01321 GMEB2 - Glucocorticoid modulatory element-binding protein 2 - Homo sapiens (Human) - GMEB2 gene Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. Indicus|evm.model.CM009503.1.470 Q2T9Z2 FND11_BOVIN 99.099 0.994012 1.003 Fibronectin type III domain-containing protein 11 - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.471 Q9H3Y6 SRMS_HUMAN 78.323 0.981818 1.01434 SRMS - Tyrosine-protein kinase Srms - Homo sapiens (Human) - SRMS gene Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907). Indicus|evm.model.CM009503.1.472 Q13882 PTK6_HUMAN 82.151 0.993151 0.971175 PTK6 - Protein-tyrosine kinase 6 - Homo sapiens (Human) - PTK6 gene Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways. Indicus|evm.model.CM009503.1.473 Q3ZCB6 PPDPF_BOVIN 97.345 0.965517 1 PPDPF - Pancreatic progenitor cell differentiation and proliferation factor - Bos taurus (Bovine) - PPDPF gene Probable regulator of exocrine pancreas development. Indicus|evm.model.CM009503.1.474 Q71V39 EF1A2_RABIT 100.000 0.331822 2.85745 EEF1A2 - Elongation factor 1-alpha 2 - Oryctolagus cuniculus (Rabbit) - EEF1A2 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Indicus|evm.model.CM009503.1.475 Q02374 NDUB2_BOVIN 98.148 0.981651 1.00926 NDUFB2 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor - Bos taurus (Bovine) - NDUFB2 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009503.1.476 P43681 ACHA4_HUMAN 83.917 0.996748 0.980861 CHRNA4 - Neuronal acetylcholine receptor subunit alpha-4 precursor - Homo sapiens (Human) - CHRNA4 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. Indicus|evm.model.CM009503.1.477 Q9EPJ9 ARFG1_MOUSE 81.818 0.244266 4.21256 Arfgap1 - ADP-ribosylation factor GTPase-activating protein 1 - Mus musculus (Mouse) - Arfgap1 gene GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). Indicus|evm.model.CM009503.1.479 A2AWP0 BIRC7_MOUSE 63.317 0.55618 1.24912 Birc7 - Baculoviral IAP repeat-containing protein 7 - Mus musculus (Mouse) - Birc7 gene Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of caspase-3, -7, and -9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. Indicus|evm.model.CM009503.1.480 Q9BYJ9 YTHD1_HUMAN 88.398 0.88707 1.09302 YTHDF1 - YTH domain-containing family protein 1 - Homo sapiens (Human) - YTHDF1 gene Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:32492408, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31388144, PubMed:31292544, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). Indicus|evm.model.CM009503.1.481 Q8NDY6 BHE23_HUMAN 90.260 0.967949 0.693333 Indicus|evm.model.CM009503.1.482 Q9BYT1 S17A9_HUMAN 88.761 0.995423 1.00229 SLC17A9 - Solute carrier family 17 member 9 - Homo sapiens (Human) - SLC17A9 gene Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. Indicus|evm.model.CM009503.1.483 Q32L52 GID8_BOVIN 100.000 0.991266 1.00439 GID8 - Glucose-induced degradation protein 8 homolog - Bos taurus (Bovine) - GID8 gene Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation. Indicus|evm.model.CM009503.1.484 Q9BTC0 DIDO1_HUMAN 69.417 0.995452 0.981696 DIDO1 - Death-inducer obliterator 1 - Homo sapiens (Human) - DIDO1 gene Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. Indicus|evm.model.CM009503.1.485 Q9UL49 TCFL5_HUMAN 92.364 0.992754 0.552 TCFL5 - Transcription factor-like 5 protein - Homo sapiens (Human) - TCFL5 gene Putative transcription factor. Isoform 3 may play a role in early spermatogenesis. Indicus|evm.model.CM009503.1.486 Q14050 CO9A3_HUMAN 88.235 0.703827 0.878655 COL9A3 - Collagen alpha-3(IX) chain precursor - Homo sapiens (Human) - COL9A3 gene Structural component of hyaline cartilage and vitreous of the eye. Indicus|evm.model.CM009503.1.487 Q9NZT2 OGFR_HUMAN 64.491 0.949627 0.791728 OGFR - Opioid growth factor receptor - Homo sapiens (Human) - OGFR gene Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. Indicus|evm.model.CM009503.1.488 Q9NV56 MRGBP_HUMAN 92.568 0.986111 0.705882 MRGBP - MRG/MORF4L-binding protein - Homo sapiens (Human) - MRGBP gene Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Indicus|evm.model.CM009503.1.489 P30989 NTR1_HUMAN 87.081 0.995227 1.00239 NTSR1 - Neurotensin receptor type 1 - Homo sapiens (Human) - NTSR1 gene G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). Indicus|evm.model.CM009503.1.490 Q96BD0 SO4A1_HUMAN 77.348 0.921569 1.05956 SLCO4A1 - Solute carrier organic anion transporter family member 4A1 - Homo sapiens (Human) - SLCO4A1 gene Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate. Indicus|evm.model.CM009503.1.492 Q3SZJ5 GATA5_BOVIN 100.000 0.937063 1.06452 GATA5 - Transcription factor GATA-5 - Bos taurus (Bovine) - GATA5 gene Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity). Indicus|evm.model.CM009503.1.493 Q8K3M5 CABL2_MOUSE 89.406 0.376218 2.15546 Cables2 - CDK5 and ABL1 enzyme substrate 2 - Mus musculus (Mouse) - Cables2 gene Unknown. Probably involved in G1-S cell cycle transition. Indicus|evm.model.CM009503.1.494 P63221 RS21_PIG 100.000 0.573427 1.72289 RPS21 - 40S ribosomal protein S21 - Sus scrofa (Pig) - RPS21 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, ribosome binding, structural constituent of ribosome, cytoplasmic translation, endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009503.1.495 Q61001 LAMA5_MOUSE 83.887 0.545455 0.949704 Lama5 - Laminin subunit alpha-5 precursor - Mus musculus (Mouse) - Lama5 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Alpha-5 may be the major laminin alpha chain of adult epithelial and/or endothelial basal laminae. Indicus|evm.model.CM009503.1.496 A1L5A6 ADRM1_BOVIN 100.000 0.995098 1.00246 ADRM1 - Proteasomal ubiquitin receptor ADRM1 - Bos taurus (Bovine) - ADRM1 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex. Indicus|evm.model.CM009503.1.497 Q9H1P3 OSBL2_HUMAN 90.208 0.995842 1.00208 OSBPL2 - Oxysterol-binding protein-related protein 2 - Homo sapiens (Human) - OSBPL2 gene Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane (PubMed:30581148). Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate (PubMed:30581148). Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) (PubMed:17428193, PubMed:19224871, PubMed:30581148). Indicus|evm.model.CM009503.1.498 Q3ZBG0 PSA7_BOVIN 100.000 0.991968 1.00403 PSMA7 - Proteasome subunit alpha type-7 - Bos taurus (Bovine) - PSMA7 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. Indicus|evm.model.CM009503.1.499 Q9BX40 LS14B_HUMAN 81.771 0.950372 1.04675 LSM14B - Protein LSM14 homolog B - Homo sapiens (Human) - LSM14B gene Required for oocyte meiotic maturation. May be involved in the storage of translationally inactive mRNAs and protect them from degradation (By similarity). Plays a role in control of mRNA translation (By similarity). Indicus|evm.model.CM009503.1.500 Q9QYN8 HRH3_RAT 92.877 0.975871 0.838202 Hrh3 - Histamine H3 receptor - Rattus norvegicus (Rat) - Hrh3 gene The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Indicus|evm.model.CM009503.1.502 Q5RDW1 MTG2_PONAB 78.079 0.995086 1.00246 MTG2 - Mitochondrial ribosome-associated GTPase 2 - Pongo abelii (Sumatran orangutan) - MTG2 gene Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process (By similarity). Indicus|evm.model.CM009503.1.503 Q08E31 CREST_BOVIN 100.000 0.88729 1.03731 SS18L1 - Calcium-responsive transactivator - Bos taurus (Bovine) - SS18L1 gene Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). Indicus|evm.model.CM009503.1.504 O00268 TAF4_HUMAN 94.965 0.997199 0.658065 TAF4 - Transcription initiation factor TFIID subunit 4 - Homo sapiens (Human) - TAF4 gene Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone. Indicus|evm.model.CM009503.1.505 P55283 CADH4_HUMAN 93.953 0.844335 1.10808 CDH4 - Cadherin-4 precursor - Homo sapiens (Human) - CDH4 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. Indicus|evm.model.CM009503.1.510 P18621 RL17_HUMAN 92.941 0.976744 0.467391 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009503.1.511 Q8IXH8 CAD26_HUMAN 64.778 0.975186 0.96875 CDH26 - Cadherin-like protein 26 precursor - Homo sapiens (Human) - CDH26 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation (PubMed:28051089). Indicus|evm.model.CM009503.1.512 Q9NTX9 F217B_HUMAN 68.052 0.992147 0.997389 FAM217B - Protein FAM217B - Homo sapiens (Human) - FAM217B gene cytosol, nucleoplasm Indicus|evm.model.CM009503.1.513 O95685 PPR3D_HUMAN 90.541 0.780919 0.946488 PPP1R3D - Protein phosphatase 1 regulatory subunit 3D - Homo sapiens (Human) - PPP1R3D gene Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Indicus|evm.model.CM009503.1.514 Q9BX26 SYCP2_HUMAN 78.356 0.541339 0.996078 SYCP2 - Synaptonemal complex protein 2 - Homo sapiens (Human) - SYCP2 gene Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements. Indicus|evm.model.CM009503.1.515 Q96KR7 PHAR3_HUMAN 87.800 0.965766 0.992844 PHACTR3 - Phosphatase and actin regulator 3 - Homo sapiens (Human) - PHACTR3 gene nucleoplasm, actin binding, actin cytoskeleton organization Indicus|evm.model.CM009503.1.516 Q96KR7 PHAR3_HUMAN 92.500 0.150579 0.463327 PHACTR3 - Phosphatase and actin regulator 3 - Homo sapiens (Human) - PHACTR3 gene nucleoplasm, actin binding, actin cytoskeleton organization Indicus|evm.model.CM009503.1.517 A5A752 EDN3_PIG 70.391 0.689922 1.26471 EDN3 - Endothelin-3 precursor - Sus scrofa (Pig) - EDN3 gene Endothelins are endothelium-derived vasoconstrictor peptides. Indicus|evm.model.CM009503.1.519 Q58DB0 PLD3B_BOVIN 100.000 0.989744 1.00515 PRELID3B - PRELI domain containing protein 3B - Bos taurus (Bovine) - PRELID3B gene mitochondrial intermembrane space, phosphatidic acid transfer activity, phospholipid transport Indicus|evm.model.CM009503.1.520 P05632 ATP5E_BOVIN 100.000 0.342105 2.23529 ATP5F1E - ATP synthase subunit epsilon, mitochondrial - Bos taurus (Bovine) - ATP5F1E gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Indicus|evm.model.CM009503.1.521 A2AQ07 TBB1_MOUSE 90.233 0.95122 1 Tubb1 - Tubulin beta-1 chain - Mus musculus (Mouse) - Tubb1 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Indicus|evm.model.CM009503.1.522 P05689 CATZ_BOVIN 100.000 0.993443 1.00329 CTSZ - Cathepsin Z precursor - Bos taurus (Bovine) - CTSZ gene Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Capable of producing kinin potentiating peptides (By similarity). Indicus|evm.model.CM009503.1.523 A5GFY4 NELFD_PIG 98.644 0.99661 1 NELFCD - Negative elongation factor D - Sus scrofa (Pig) - NELFCD gene Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). Indicus|evm.model.CM009503.1.524 P04896 GNAS2_BOVIN 95.968 0.369154 2.55076 GNAS - Guanine nucleotide-binding protein G(s) subunit alpha isoforms short - Bos taurus (Bovine) - GNAS gene Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:2022671, PubMed:9395396, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2 (By similarity). Indicus|evm.model.CM009503.1.525 O18979 GNAS3_BOVIN 99.585 0.991736 1.00415 GNAS - Neuroendocrine secretory protein 55 precursor - Bos taurus (Bovine) - GNAS gene negative regulation of multicellular organism growth Indicus|evm.model.CM009503.1.530 Q5R7G6 PEPL1_PONAB 94.304 0.973251 0.929254 NPEPL1 - Probable aminopeptidase NPEPL1 - Pongo abelii (Sumatran orangutan) - NPEPL1 gene Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Indicus|evm.model.CM009503.1.531 Q8BVI5 STX16_MOUSE 95.050 0.923547 1.00307 Stx16 - Syntaxin-16 - Mus musculus (Mouse) - Stx16 gene SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Indicus|evm.model.CM009503.1.533 Q8NCL9 APCDL_HUMAN 79.098 0.987755 0.978044 APCDD1L - Protein APCDD1-like precursor - Homo sapiens (Human) - APCDD1L gene Indicus|evm.model.CM009503.1.534 A2VDZ9 VAPB_BOVIN 99.556 0.910569 1.01235 VAPB - Vesicle-associated membrane protein-associated protein B - Bos taurus (Bovine) - VAPB gene Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. Indicus|evm.model.CM009503.1.535 Q9UL26 RB22A_HUMAN 98.454 0.989744 1.00515 RAB22A - Ras-related protein Rab-22A - Homo sapiens (Human) - RAB22A gene Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905). Indicus|evm.model.CM009503.1.536 Q8K2V1 PP4R1_MOUSE 84.615 0.0459559 0.572029 Ppp4r1 - Serine/threonine-protein phosphatase 4 regulatory subunit 1 - Mus musculus (Mouse) - Ppp4r1 gene Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3 (By similarity). Indicus|evm.model.CM009503.1.538 Q9BZ19 ANR60_HUMAN 67.368 0.850299 0.968116 ANKRD60 - Ankyrin repeat domain-containing protein 60 - Homo sapiens (Human) - ANKRD60 gene Indicus|evm.model.CM009503.1.539 Q9H1P6 CT085_HUMAN 86.861 0.985507 1.0073 C20orf85 - Uncharacterized protein C20orf85 - Homo sapiens (Human) - C20orf85 gene Indicus|evm.model.CM009503.1.541 Q969W9 PMEPA_HUMAN 91.473 0.992278 0.902439 PMEPA1 - Protein TMEPAI - Homo sapiens (Human) - PMEPA1 gene Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). Indicus|evm.model.CM009503.1.542 Q9H171 ZBP1_HUMAN 54.208 0.965432 0.944056 ZBP1 - Z-DNA-binding protein 1 - Homo sapiens (Human) - ZBP1 gene Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death (PubMed:32200799). Once activated upon Z-RNA-binding, ZBP1 interacts with RIPK3, inducing the complementary pathways of apoptosis, necroptosis and pyroptosis (By similarity). Acts as a key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members: ZBP1-dependent necroptosis involves RIPK3 stimulation, which phosphorylates and activates MLKL, triggering execution of programmed necrosis (By similarity). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799). ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Indicus|evm.model.CM009503.1.543 Q8HYZ4 PCKGC_BOVIN 98.714 0.99679 1.00161 PCK1 - Phosphoenolpyruvate carboxykinase, cytosolic [GTP] - Bos taurus (Bovine) - PCK1 gene Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis. Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (By similarity). Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis. The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis (By similarity). In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor. The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes (By similarity). Indicus|evm.model.CM009503.1.544 Q08705 CTCF_CHICK 67.027 0.548193 0.912088 CTCF - Transcriptional repressor CTCF - Gallus gallus (Chicken) - CTCF gene Acts as both a transcriptional activator and repressor of the MYC gene. Indicus|evm.model.CM009503.1.545 Q9H0Z9 RBM38_HUMAN 96.234 0.991667 1.00418 RBM38 - RNA-binding protein 38 - Homo sapiens (Human) - RBM38 gene RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. Indicus|evm.model.CM009503.1.546 Q5E9A4 RAE1L_BOVIN 99.728 0.527299 1.8913 RAE1 - mRNA export factor - Bos taurus (Bovine) - RAE1 gene Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Indicus|evm.model.CM009503.1.547 P18075 BMP7_HUMAN 97.912 0.99537 1.00232 BMP7 - Bone morphogenetic protein 7 precursor - Homo sapiens (Human) - BMP7 gene Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:9748228, PubMed:12667445). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061). Indicus|evm.model.CM009503.1.549 Q92754 AP2C_HUMAN 94.222 0.995565 1.00222 TFAP2C - Transcription factor AP-2 gamma - Homo sapiens (Human) - TFAP2C gene Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Indicus|evm.model.CM009503.1.550 Q3SYR7 RL9_BOVIN 97.917 0.989637 1.00521 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009503.1.551 Q5JX71 F209A_HUMAN 60.819 0.976331 0.988304 FAM209A - Protein FAM209A precursor - Homo sapiens (Human) - FAM209A gene extracellular exosome, nucleus Indicus|evm.model.CM009503.1.552 Q0VCR1 RTF2_BOVIN 99.666 0.993333 1.00334 RTF2 - Replication termination factor 2 - Bos taurus (Bovine) - RTF2 gene Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Indicus|evm.model.CM009503.1.553 A5GFW5 CASS4_PIG 76.942 0.997537 1.03571 CASS4 - Cas scaffolding protein family member 4 - Sus scrofa (Pig) - CASS4 gene Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading (By similarity). Indicus|evm.model.CM009503.1.554 Q5BJQ6 CSTF1_RAT 99.536 0.99537 1.00232 Cstf1 - Cleavage stimulation factor subunit 1 - Rattus norvegicus (Rat) - Cstf1 gene One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (By similarity). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity). Indicus|evm.model.CM009503.1.555 Q2TA06 AURKA_BOVIN 100.000 0.995037 1.00249 AURKA - Aurora kinase A - Bos taurus (Bovine) - AURKA gene Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (By similarity). Indicus|evm.model.CM009503.1.556 Q96KR6 F210B_HUMAN 86.260 0.890411 0.760417 FAM210B - Protein FAM210B, mitochondrial precursor - Homo sapiens (Human) - FAM210B gene Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398). Indicus|evm.model.CM009503.1.557 P41968 MC3R_HUMAN 91.641 0.993827 1.0031 MC3R - Melanocortin receptor 3 - Homo sapiens (Human) - MC3R gene Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. Indicus|evm.model.CM009503.1.558 Q5JXA9 SIRB2_HUMAN 74.825 0.475 1.75439 SIRPB2 - Signal-regulatory protein beta-2 precursor - Homo sapiens (Human) - SIRPB2 gene plasma membrane Indicus|evm.model.CM009503.1.559 Q3SZC4 NSF1C_BOVIN 100.000 0.994609 1.0027 NSFL1C - NSFL1 cofactor p47 - Bos taurus (Bovine) - NSFL1C gene Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Indicus|evm.model.CM009503.1.560 P18203 FKB1A_BOVIN 85.185 0.978495 0.861111 FKBP1A - Peptidyl-prolyl cis-trans isomerase FKBP1A - Bos taurus (Bovine) - FKBP1A gene Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Indicus|evm.model.CM009503.1.561 Q9H190 SDCB2_HUMAN 80.623 0.979381 0.996575 SDCBP2 - Syntenin-2 - Homo sapiens (Human) - SDCBP2 gene Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997). Indicus|evm.model.CM009503.1.562 O15079 SNPH_HUMAN 90.744 0.858131 1.17004 SNPH - Syntaphilin - Homo sapiens (Human) - SNPH gene Inhibits SNARE complex formation by absorbing free syntaxin-1. Indicus|evm.model.CM009503.1.563 D2HSB3 RD21L_AILME 84.505 0.996396 1.00181 RAD21L1 - Double-strand-break repair protein rad21-like protein 1 - Ailuropoda melanoleuca (Giant panda) - RAD21L1 gene Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity). Indicus|evm.model.CM009503.1.564 Q9NUR3 TM74B_HUMAN 89.700 0.991453 0.914062 TMEM74B - Transmembrane protein 74B - Homo sapiens (Human) - TMEM74B gene Indicus|evm.model.CM009503.1.565 Q3SX30 PSMF1_BOVIN 100.000 0.99262 1.0037 PSMF1 - Proteasome inhibitor PI31 subunit - Bos taurus (Bovine) - PSMF1 gene Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). Indicus|evm.model.CM009503.1.566 Q2I0M5 RSPO4_HUMAN 82.456 0.97235 0.92735 RSPO4 - R-spondin-4 precursor - Homo sapiens (Human) - RSPO4 gene Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076). Indicus|evm.model.CM009503.1.567 Q24K15 ANGP4_BOVIN 89.357 0.995526 0.89759 ANGPT4 - Angiopoietin-4 precursor - Bos taurus (Bovine) - ANGPT4 gene Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis (By similarity). Indicus|evm.model.CM009503.1.568 Q58DG5 F110A_BOVIN 100.000 0.993243 1.00339 FAM110A - Protein FAM110A - Bos taurus (Bovine) - FAM110A gene Indicus|evm.model.CM009503.1.569 Q5E9R1 S52A3_BOVIN 100.000 0.995726 1.00214 SLC52A3 - Solute carrier family 52, riboflavin transporter, member 3 - Bos taurus (Bovine) - SLC52A3 gene Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Indicus|evm.model.CM009503.1.570 Q9NQ03 SCRT2_HUMAN 100.000 0.145833 0.469055 SCRT2 - Transcriptional repressor scratch 2 - Homo sapiens (Human) - SCRT2 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009503.1.571 Q9BYN0 SRXN1_HUMAN 94.891 0.978417 1.0146 SRXN1 - Sulfiredoxin-1 - Homo sapiens (Human) - SRXN1 gene Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Indicus|evm.model.CM009503.1.572 Q60756 TCF15_MOUSE 89.524 0.717241 0.74359 Tcf15 - Transcription factor 15 - Mus musculus (Mouse) - Tcf15 gene Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency (PubMed:7597044, PubMed:8955271, PubMed:23395635, PubMed:32669716, PubMed:24038871). Essential for the mesenchymal to epithelial transition associated with somite formation (PubMed:7597044, PubMed:8955271, PubMed:24038871). Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles (PubMed:8955271). Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition (PubMed:24038871). Also plays a key role in regulation of stem cell pluripotency (PubMed:23395635, PubMed:32669716). Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation (PubMed:23395635). Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal (PubMed:32669716). Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (PubMed:25561514). Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes (PubMed:15226298, PubMed:23395635). Indicus|evm.model.CM009503.1.573 P68400 CSK21_HUMAN 99.379 0.987692 0.831202 CSNK2A1 - Casein kinase II subunit alpha - Homo sapiens (Human) - CSNK2A1 gene Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621, PubMed:24962073). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387552, PubMed:19387551). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387552, PubMed:19387551). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis (PubMed:11239457). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551, PubMed:23123191). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). Indicus|evm.model.CM009503.1.574 Q2T9Q1 TBC20_BOVIN 100.000 0.99505 1.00248 TBC1D20 - TBC1 domain family member 20 - Bos taurus (Bovine) - TBC1D20 gene GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. Indicus|evm.model.CM009503.1.575 Q9BYM8 HOIL1_HUMAN 94.706 0.996086 1.00196 RBCK1 - RanBP-type and C3HC4-type zinc finger-containing protein 1 - Homo sapiens (Human) - RBCK1 gene E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. Indicus|evm.model.CM009503.1.576 Q0VCE3 TRIB3_BOVIN 100.000 0.994413 1.0028 TRIB3 - Tribbles homolog 3 - Bos taurus (Bovine) - TRIB3 gene Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (By similarity). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (By similarity). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity. Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases (By similarity). Can inhibit APOBEC3A editing of nuclear DNA (By similarity). Indicus|evm.model.CM009503.1.577 Q9GZP1 NRSN2_HUMAN 86.634 0.985294 1 NRSN2 - Neurensin-2 - Homo sapiens (Human) - NRSN2 gene May play a role in maintenance and/or transport of vesicles. Indicus|evm.model.CM009503.1.578 O15370 SOX12_HUMAN 100.000 0.330159 1 SOX12 - Transcription factor SOX-12 - Homo sapiens (Human) - SOX12 gene Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3' (By similarity). Acts as a transcriptional activator (By similarity). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions (By similarity). Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation (By similarity). Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). Indicus|evm.model.CM009503.1.579 Q9NUD5 ZCHC3_HUMAN 83.495 0.971338 0.779156 ZCCHC3 - Zinc finger CCHC domain-containing protein 3 - Homo sapiens (Human) - ZCCHC3 gene Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5 (PubMed:30193849). Indicus|evm.model.CM009503.1.580 Q9NUD7 CT096_HUMAN 58.953 0.994475 0.997245 C20orf96 - Uncharacterized protein C20orf96 - Homo sapiens (Human) - C20orf96 gene Indicus|evm.model.CM009503.1.581 A4H265 DB132_MACFA 46.154 0.712644 0.915789 DEFB132 - Beta-defensin 132 precursor - Macaca fascicularis (Crab-eating macaque) - DEFB132 gene Has antibacterial activity. Indicus|evm.model.CM009503.1.582 A4H257 DB129_GORGO 63.946 0.776596 1.02732 DEFB129 - Beta-defensin 129 precursor - Gorilla gorilla gorilla (Western lowland gorilla) - DEFB129 gene Has antibacterial activity. Indicus|evm.model.CM009503.1.584 Q5J5Z9 DB122_MACMU 67.143 0.971429 1.01449 DEFB122 - Beta-defensin 122 precursor - Macaca mulatta (Rhesus macaque) - DEFB122 gene Has antibacterial activity. Indicus|evm.model.CM009503.1.585 Q8K3U4 DFB36_MOUSE 68.519 0.53 1.49254 Defb36 - Beta-defensin 36 precursor - Mus musculus (Mouse) - Defb36 gene Has antibacterial activity. Indicus|evm.model.CM009503.1.586 Q5J5D0 DB123_MACMU 69.231 0.941176 1.01493 DEFB123 - Beta-defensin 123 precursor - Macaca mulatta (Rhesus macaque) - DEFB123 gene Has antibacterial activity. Indicus|evm.model.CM009503.1.587 Q30KK4 DB124_PANTR 77.612 0.956522 0.971831 DEFB124 - Beta-defensin 124 precursor - Pan troglodytes (Chimpanzee) - DEFB124 gene Has antibacterial activity. Indicus|evm.model.CM009503.1.588 O75628 REM1_HUMAN 91.946 0.993311 1.00336 REM1 - GTP-binding protein REM 1 - Homo sapiens (Human) - REM1 gene Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling. Indicus|evm.model.CM009503.1.589 Q8TCT9 HM13_HUMAN 97.082 0.994709 1.00265 HM13 - Minor histocompatibility antigen H13 - Homo sapiens (Human) - HM13 gene Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity). Indicus|evm.model.CM009503.1.590 P41134 ID1_HUMAN 91.489 0.903226 1 ID1 - DNA-binding protein inhibitor ID-1 - Homo sapiens (Human) - ID1 gene Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Indicus|evm.model.CM009503.1.591 Q96KJ9 COX42_HUMAN 79.532 0.988372 1.00585 COX4I2 - Cytochrome c oxidase subunit 4 isoform 2, mitochondrial precursor - Homo sapiens (Human) - COX4I2 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009503.1.592 Q07817 B2CL1_HUMAN 97.826 0.867424 1.13305 BCL2L1 - Bcl-2-like protein 1 - Homo sapiens (Human) - BCL2L1 gene Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Indicus|evm.model.CM009503.1.593 A6H6Z7 TPX2_BOVIN 93.976 0.997326 1.0625 TPX2 - Targeting protein for Xklp2 - Bos taurus (Bovine) - TPX2 gene Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation. Indicus|evm.model.CM009503.1.594 A4IFM7 MYLK2_BOVIN 100.000 0.996795 1.00161 MYLK2 - Myosin light chain kinase 2, skeletal/cardiac muscle - Bos taurus (Bovine) - MYLK2 gene Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity). Indicus|evm.model.CM009503.1.595 O43638 FOXS1_HUMAN 85.455 0.993958 1.00303 FOXS1 - Forkhead box protein S1 - Homo sapiens (Human) - FOXS1 gene Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity). Indicus|evm.model.CM009503.1.597 Q9H1R2 DUS15_HUMAN 93.662 0.597458 0.8 DUSP15 - Dual specificity protein phosphatase 15 - Homo sapiens (Human) - DUSP15 gene May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334). Indicus|evm.model.CM009503.1.598 Q3SZH6 TTLL9_BOVIN 100.000 0.831301 1.06725 TTLL9 - Probable tubulin polyglutamylase TTLL9 - Bos taurus (Bovine) - TTLL9 gene Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Acts when complexed with other proteins. By mediating tubulin polyglutamylation, plays a role in the establishment of microtubule heterogeneity in sperm flagella. Indicus|evm.model.CM009503.1.599 Q148L7 PDRG1_BOVIN 100.000 0.985075 1.00752 PDRG1 - p53 and DNA damage-regulated protein 1 - Bos taurus (Bovine) - PDRG1 gene May play a role in chaperone-mediated protein folding. Indicus|evm.model.CM009503.1.600 Q49LS1 XKR7_PANTR 88.718 0.989796 0.338515 XKR7 - XK-related protein 7 - Pan troglodytes (Chimpanzee) - XKR7 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Indicus|evm.model.CM009503.1.601 Q5GH72 XKR7_HUMAN 81.062 0.96861 0.770294 XKR7 - XK-related protein 7 - Homo sapiens (Human) - XKR7 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Indicus|evm.model.CM009503.1.602 Q9NUG4 CCM2L_HUMAN 97.849 0.419501 0.772329 CCM2L - Cerebral cavernous malformations 2 protein-like - Homo sapiens (Human) - CCM2L gene Indicus|evm.model.CM009503.1.603 Q95M30 HCK_MACFA 91.468 0.967245 1.02976 HCK - Tyrosine-protein kinase HCK - Macaca fascicularis (Crab-eating macaque) - HCK gene Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity). Indicus|evm.model.CM009503.1.604 A5D7E2 TM9S4_BOVIN 100.000 0.99689 1.00156 TM9SF4 - Transmembrane 9 superfamily member 4 precursor - Bos taurus (Bovine) - TM9SF4 gene Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Indicus|evm.model.CM009503.1.605 Q8VD63 TSYL4_MOUSE 61.905 0.350427 0.288177 Tspyl4 - Testis-specific Y-encoded-like protein 4 - Mus musculus (Mouse) - Tspyl4 gene chromatin, nucleus, chromatin binding, histone binding Indicus|evm.model.CM009503.1.606 Q9UPG8 PLAL2_HUMAN 97.782 0.995976 1.00202 PLAGL2 - Zinc finger protein PLAGL2 - Homo sapiens (Human) - PLAGL2 gene Shows weak transcriptional activatory activity. Indicus|evm.model.CM009503.1.607 Q6EV69 OFUT1_PANTR 92.327 0.994898 1.01031 POFUT1 - GDP-fucose protein O-fucosyltransferase 1 precursor - Pan troglodytes (Chimpanzee) - POFUT1 gene Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs). Indicus|evm.model.CM009503.1.608 O15066 KIF3B_HUMAN 97.456 0.997312 0.995984 KIF3B - Kinesin-like protein KIF3B - Homo sapiens (Human) - KIF3B gene Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity). Plays a role in cilia formation (PubMed:32386558). Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (PubMed:32386558). Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (By similarity). Indicus|evm.model.CM009503.1.609 Q8IXJ9 ASXL1_HUMAN 79.183 0.998673 0.977936 ASXL1 - Polycomb group protein ASXL1 - Homo sapiens (Human) - ASXL1 gene Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). Indicus|evm.model.CM009503.1.610 Q96MY1 NOL4L_HUMAN 95.642 0.739353 1.34633 NOL4L - Nucleolar protein 4-like - Homo sapiens (Human) - NOL4L gene cytosol, nucleoplasm Indicus|evm.model.CM009503.1.611 Q3MHX1 COMD7_BOVIN 100.000 0.99005 1.005 COMMD7 - COMM domain-containing protein 7 - Bos taurus (Bovine) - COMMD7 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity. Indicus|evm.model.CM009503.1.612 Q9UBC3 DNM3B_HUMAN 89.767 0.997611 0.981243 DNMT3B - DNA (cytosine-5)-methyltransferase 3B - Homo sapiens (Human) - DNMT3B gene Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). Indicus|evm.model.CM009503.1.613 Q3ZBD9 MARE1_BOVIN 86.000 0.849206 0.940299 MAPRE1 - Microtubule-associated protein RP/EB family member 1 - Bos taurus (Bovine) - MAPRE1 gene Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity). May play a role in cell migration (By similarity). Indicus|evm.model.CM009503.1.615 Q8TC36 SUN5_HUMAN 80.481 0.994638 0.984169 SUN5 - SUN domain-containing protein 5 - Homo sapiens (Human) - SUN5 gene Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. Indicus|evm.model.CM009503.1.616 Q8N4F0 BPIB2_HUMAN 73.529 0.958696 1.00437 BPIFB2 - BPI fold-containing family B member 2 precursor - Homo sapiens (Human) - BPIFB2 gene endoplasmic reticulum lumen, extracellular exosome, extracellular region, antimicrobial humoral response, cellular protein metabolic process, post-translational protein modification Indicus|evm.model.CM009503.1.617 Q8BU51 BPIB6_MOUSE 71.388 0.88191 0.886414 Bpifb6 - BPI fold-containing family B member 6 precursor - Mus musculus (Mouse) - Bpifb6 gene Indicus|evm.model.CM009503.1.618 Q05704 BPIB4_RAT 90.630 0.567493 1.76499 Bpifb4 - BPI fold-containing family B member 4 precursor - Rattus norvegicus (Rat) - Bpifb4 gene May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity). Indicus|evm.model.CM009503.1.619 P79124 SPL2A_BOVIN 99.563 0.140135 6.80753 SPLUNC2A - Short palate, lung and nasal epithelium carcinoma-associated protein 2A precursor - Bos taurus (Bovine) - SPLUNC2A gene secretory granule, lipopolysaccharide binding Indicus|evm.model.CM009503.1.620 Q9BQP9 BPIA3_HUMAN 67.094 0.974895 0.940945 BPIFA3 - BPI fold-containing family A member 3 precursor - Homo sapiens (Human) - BPIFA3 gene Indicus|evm.model.CM009503.1.621 Q8SPU5 BPIA1_BOVIN 98.824 0.992188 1.00392 BPIFA1 - BPI fold-containing family A member 1 precursor - Bos taurus (Bovine) - BPIFA1 gene Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. Indicus|evm.model.CM009503.1.622 Q8SPF8 BPIB1_BOVIN 99.577 0.995781 1.00211 BPIFB1 - BPI fold-containing family B member 1 precursor - Bos taurus (Bovine) - BPIFB1 gene May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS (By similarity). Indicus|evm.model.CM009503.1.624 Q96SZ6 CK5P1_HUMAN 87.231 0.99661 0.981697 CDK5RAP1 - Mitochondrial tRNA methylthiotransferase CDK5RAP1 precursor - Homo sapiens (Human) - CDK5RAP1 gene Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease (PubMed:25738458). Indicus|evm.model.CM009503.1.625 Q0P5E6 SNTA1_BOVIN 99.406 0.996047 1.00198 SNTA1 - Alpha-1-syntrophin - Bos taurus (Bovine) - SNTA1 gene Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). Indicus|evm.model.CM009503.1.626 O43439 MTG8R_HUMAN 96.604 0.986577 0.986755 CBFA2T2 - Protein CBFA2T2 - Homo sapiens (Human) - CBFA2T2 gene Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). Indicus|evm.model.CM009503.1.627 P18621 RL17_HUMAN 89.535 0.965909 0.478261 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009503.1.628 A2VDW6 NECA3_BOVIN 99.687 0.946429 0.938547 NECAB3 - N-terminal EF-hand calcium-binding protein 3 - Bos taurus (Bovine) - NECAB3 gene Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta (By similarity). May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3 (By similarity). Indicus|evm.model.CM009503.1.629 Q01094 E2F1_HUMAN 89.488 0.633562 1.33638 E2F1 - Transcription factor E2F1 - Homo sapiens (Human) - E2F1 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599). Indicus|evm.model.CM009503.1.630 A5PJL1 PXMP4_BOVIN 99.057 0.99061 1.00472 PXMP4 - Peroxisomal membrane protein 4 - Bos taurus (Bovine) - PXMP4 gene peroxisomal membrane Indicus|evm.model.CM009503.1.631 Q9BYN7 ZN341_HUMAN 93.326 0.997661 1.00117 ZNF341 - Zinc finger protein 341 - Homo sapiens (Human) - ZNF341 gene Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription. Indicus|evm.model.CM009503.1.632 Q9H444 CHM4B_HUMAN 97.321 0.991111 1.00446 CHMP4B - Charged multivesicular body protein 4b - Homo sapiens (Human) - CHMP4B gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Indicus|evm.model.CM009503.1.633 Q64012 RALY_MOUSE 87.500 0.925466 1.03205 Raly - RNA-binding protein Raly - Mus musculus (Mouse) - Raly gene RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver (PubMed:27251289). Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (PubMed:27251289). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (By similarity). Indicus|evm.model.CM009503.1.634 Q5E9D0 IF2B_BOVIN 99.700 0.994012 1.003 EIF2S2 - Eukaryotic translation initiation factor 2 subunit 2 - Bos taurus (Bovine) - EIF2S2 gene eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Indicus|evm.model.CM009503.1.635 Q29414 ASIP_BOVIN 98.496 0.984848 0.992481 ASIP - Agouti-signaling protein precursor - Bos taurus (Bovine) - ASIP gene Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). Indicus|evm.model.CM009503.1.636 Q3MHL4 SAHH_BOVIN 100.000 0.995381 1.00231 AHCY - Adenosylhomocysteinase - Bos taurus (Bovine) - AHCY gene Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Indicus|evm.model.CM009503.1.637 P61255 RL26_MOUSE 98.621 0.986301 1.0069 Rpl26 - 60S ribosomal protein L26 - Mus musculus (Mouse) - Rpl26 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009503.1.638 Q8C863 ITCH_MOUSE 95.486 0.997683 0.998843 Itch - E3 ubiquitin-protein ligase Itchy - Mus musculus (Mouse) - Itch gene Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:15358865, PubMed:16446428, PubMed:17592138, PubMed:18628966, PubMed:20392206, PubMed:25632008). It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (By similarity). Involved in the control of inflammatory signaling pathways (By similarity). Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (By similarity). Promotes the association of the complex after TNF stimulation (By similarity). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (By similarity). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (By similarity). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (By similarity). Regulates the transcriptional activity of several transcription factors involved in immune response (PubMed:15358865, PubMed:11828324). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (By similarity). Mediates JUN ubiquitination and degradation (PubMed:15358865). Mediates JUNB ubiquitination and degradation (PubMed:11828324, PubMed:15358865). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (PubMed:11828324). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (By similarity). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (By similarity). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (By similarity). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (By similarity). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (By similarity). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:18628966). Ubiquitinates SNX9 (By similarity). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (PubMed:25632008). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (By similarity). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (By similarity). Indicus|evm.model.CM009503.1.639 P62628 DLRB1_RAT 100.000 0.979381 1.01042 Dynlrb1 - Dynein light chain roadblock-type 1 - Rattus norvegicus (Rat) - Dynlrb1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Indicus|evm.model.CM009503.1.640 Q2HJ23 MLP3A_BOVIN 100.000 0.983607 1.00826 MAP1LC3A - Microtubule-associated proteins 1A/1B light chain 3A precursor - Bos taurus (Bovine) - MAP1LC3A gene Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Indicus|evm.model.CM009503.1.641 Q9H490 PIGU_HUMAN 96.322 0.995413 1.0023 PIGU - Phosphatidylinositol glycan anchor biosynthesis class U protein - Homo sapiens (Human) - PIGU gene Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI. Indicus|evm.model.CM009503.1.642 Q3MHN0 PSB6_BOVIN 75.229 0.84375 0.535565 PSMB6 - Proteasome subunit beta type-6 precursor - Bos taurus (Bovine) - PSMB6 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues. Indicus|evm.model.CM009503.1.643 Q8IXH6 T53I2_HUMAN 86.161 0.991111 1.02273 TP53INP2 - Tumor protein p53-inducible nuclear protein 2 - Homo sapiens (Human) - TP53INP2 gene Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. Indicus|evm.model.CM009503.1.644 Q14686 NCOA6_HUMAN 95.477 0.460065 1.03781 NCOA6 - Nuclear receptor coactivator 6 - Homo sapiens (Human) - NCOA6 gene Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Indicus|evm.model.CM009503.1.645 Q0V8L2 GGT7_BOVIN 100.000 0.996983 1.00151 GGT7 - Glutathione hydrolase 7 precursor - Bos taurus (Bovine) - GGT7 gene Cleaves glutathione conjugates. Indicus|evm.model.CM009503.1.646 Q9NR19 ACSA_HUMAN 93.866 0.997151 1.00143 ACSS2 - Acetyl-coenzyme A synthetase, cytoplasmic - Homo sapiens (Human) - ACSS2 gene Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity). Indicus|evm.model.CM009503.1.647 Q5EAC2 GSHB_BOVIN 99.156 0.987474 1.01055 GSS - Glutathione synthetase - Bos taurus (Bovine) - GSS gene ATP binding, glutathione binding, magnesium ion binding, protein homodimerization activity Indicus|evm.model.CM009503.1.648 A7E2Y1 MYH7B_HUMAN 97.424 0.99897 0.979324 MYH7B - Myosin-7B - Homo sapiens (Human) - MYH7B gene Involved in muscle contraction. Indicus|evm.model.CM009503.1.649 Q8TEL6 TP4AP_HUMAN 98.871 0.997494 1.00125 TRPC4AP - Short transient receptor potential channel 4-associated protein - Homo sapiens (Human) - TRPC4AP gene Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. Indicus|evm.model.CM009503.1.650 Q9BV94 EDEM2_HUMAN 96.367 0.996546 1.00173 EDEM2 - ER degradation-enhancing alpha-mannosidase-like protein 2 precursor - Homo sapiens (Human) - EDEM2 gene Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity). Indicus|evm.model.CM009503.1.652 Q28105 EPCR_BOVIN 100.000 0.991736 1.00415 PROCR - Endothelial protein C receptor precursor - Bos taurus (Bovine) - PROCR gene Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. Indicus|evm.model.CM009503.1.653 Q9Y5R2 MMP24_HUMAN 98.872 0.996248 0.826357 MMP24 - Matrix metalloproteinase-24 precursor - Homo sapiens (Human) - MMP24 gene Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). Indicus|evm.model.CM009503.1.654 Q9TU47 IF6_BOVIN 100.000 0.99187 1.00408 EIF6 - Eukaryotic translation initiation factor 6 - Bos taurus (Bovine) - EIF6 gene Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (By similarity). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). Indicus|evm.model.CM009503.1.655 Q9BQN1 FA83C_HUMAN 79.620 0.997275 0.982597 FAM83C - Protein FAM83C - Homo sapiens (Human) - FAM83C gene May play a role in MAPK signaling. Indicus|evm.model.CM009503.1.656 Q9NVA1 UQCC1_HUMAN 100.000 0.184549 0.779264 UQCC1 - Ubiquinol-cytochrome-c reductase complex assembly factor 1 - Homo sapiens (Human) - UQCC1 gene Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability. Indicus|evm.model.CM009503.1.657 P43026 GDF5_HUMAN 95.609 0.996 0.998004 GDF5 - Growth/differentiation factor 5 precursor - Homo sapiens (Human) - GDF5 gene Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Indicus|evm.model.CM009503.1.658 Q9BV73 CP250_HUMAN 81.439 0.999179 0.997133 CEP250 - Centrosome-associated protein CEP250 - Homo sapiens (Human) - CEP250 gene May be involved in ciliogenesis (PubMed:28005958). Probably plays an important role in centrosome cohesion during interphase. Indicus|evm.model.CM009503.1.661 Q5EAE0 ERGI3_BOVIN 100.000 0.797059 0.887728 ERGIC3 - Endoplasmic reticulum-Golgi intermediate compartment protein 3 - Bos taurus (Bovine) - ERGIC3 gene Possible role in transport between endoplasmic reticulum and Golgi. Indicus|evm.model.CM009503.1.662 A9Z1Z3 FR1L4_HUMAN 79.933 0.895119 1.07358 FER1L4 - Fer-1-like protein 4 - Homo sapiens (Human) - FER1L4 gene plasma membrane organization Indicus|evm.model.CM009503.1.663 Q9NPE6 SPAG4_HUMAN 87.943 0.956916 1.00915 SPAG4 - Sperm-associated antigen 4 protein - Homo sapiens (Human) - SPAG4 gene Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. Indicus|evm.model.CM009503.1.664 Q08DB4 CPNE1_BOVIN 99.814 0.987109 1.01117 CPNE1 - Copine-1 - Bos taurus (Bovine) - CPNE1 gene Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL. Indicus|evm.model.CM009503.1.665 Q5RDE7 NFS1_PONAB 95.128 0.938865 1.00219 NFS1 - Cysteine desulfurase, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - NFS1 gene Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor (By similarity). Indicus|evm.model.CM009503.1.666 P60603 ROMO1_MOUSE 100.000 0.975 1.01266 Romo1 - Reactive oxygen species modulator 1 - Mus musculus (Mouse) - Romo1 gene Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity). Indicus|evm.model.CM009503.1.667 Q14498 RBM39_HUMAN 100.000 0.996234 1.00189 RBM39 - RNA-binding protein 39 - Homo sapiens (Human) - RBM39 gene RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:31271494, PubMed:28437394, PubMed:28302793, PubMed:24795046). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). Indicus|evm.model.CM009503.1.668 Q9BVI0 PHF20_HUMAN 91.330 0.998022 0.999012 PHF20 - PHD finger protein 20 - Homo sapiens (Human) - PHF20 gene Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. Indicus|evm.model.CM009503.1.669 Q32PG5 SCND1_BOVIN 99.438 0.988827 1.00562 SCAND1 - SCAN domain-containing protein 1 - Bos taurus (Bovine) - SCAND1 gene May regulate transcriptional activity. Indicus|evm.model.CM009503.1.670 Q95JR6 CNBD2_MACFA 73.756 0.835498 1.18462 CNBD2 - Cyclic nucleotide-binding domain-containing protein 2 - Macaca fascicularis (Crab-eating macaque) - CNBD2 gene Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm. Indicus|evm.model.CM009503.1.671 Q9H4G0 E41L1_HUMAN 94.779 0.997699 0.986379 EPB41L1 - Band 4.1-like protein 1 - Homo sapiens (Human) - EPB41L1 gene May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. Indicus|evm.model.CM009503.1.672 Q08DJ7 AAR2_BOVIN 100.000 0.994805 1.0026 AAR2 - Protein AAR2 homolog - Bos taurus (Bovine) - AAR2 gene Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Indicus|evm.model.CM009503.1.673 Q9Y2H0 DLGP4_HUMAN 97.480 0.997986 1.00101 DLGAP4 - Disks large-associated protein 4 - Homo sapiens (Human) - DLGAP4 gene May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Indicus|evm.model.CM009503.1.674 P02612 MLRM_CHICK 100.000 0.988439 1.00581 Myosin regulatory light chain 2, smooth muscle major isoform - Gallus gallus (Chicken) Indicus|evm.model.CM009503.1.675 Q9GZN2 TGIF2_HUMAN 92.827 0.991597 1.00422 TGIF2 - Homeobox protein TGIF2 - Homo sapiens (Human) - TGIF2 gene Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. Indicus|evm.model.CM009503.1.676 Q9CQT9 RCAF1_MOUSE 95.349 0.984615 1.00775 Rab5if - Respirasome Complex Assembly Factor 1 - Mus musculus (Mouse) - Rab5if gene Acts as an assembly factor for mitochondrial respiratory complexes. Indicus|evm.model.CM009503.1.677 Q9H6Q3 SLAP2_HUMAN 83.969 0.938628 1.0613 SLA2 - Src-like-adapter 2 - Homo sapiens (Human) - SLA2 gene Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Indicus|evm.model.CM009503.1.678 A7MB28 NDRG3_BOVIN 100.000 0.994681 1.00267 NDRG3 - Protein NDRG3 - Bos taurus (Bovine) - NDRG3 gene cytoplasm, signal transduction Indicus|evm.model.CM009503.1.679 Q0VCA5 SAMH1_BOVIN 99.390 0.92467 0.901528 SAMHD1 - Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 - Bos taurus (Bovine) - SAMHD1 gene Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity (By similarity). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools. Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication. Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation. Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (By similarity). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). Indicus|evm.model.CM009503.1.680 O43598 DNPH1_HUMAN 82.443 0.844156 0.885057 DNPH1 - 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 - Homo sapiens (Human) - DNPH1 gene Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. Indicus|evm.model.CM009503.1.682 P28749 RBL1_HUMAN 94.419 0.408397 0.490637 RBL1 - Retinoblastoma-like protein 1 - Homo sapiens (Human) - RBL1 gene Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). Indicus|evm.model.CM009503.1.683 P28749 RBL1_HUMAN 94.567 0.349005 2.07116 RBL1 - Retinoblastoma-like protein 1 - Homo sapiens (Human) - RBL1 gene Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). Indicus|evm.model.CM009503.1.684 Q9H579 MROH8_HUMAN 66.151 0.561749 1.89441 MROH8 - Protein MROH8 - Homo sapiens (Human) - MROH8 gene Indicus|evm.model.CM009503.1.685 Q3SZI6 RPN2_BOVIN 100.000 0.996835 1.00158 RPN2 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 precursor - Bos taurus (Bovine) - RPN2 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Indicus|evm.model.CM009503.1.686 P63292 SLIB_BOVIN 100.000 0.711268 1.33962 GHRH - Somatoliberin precursor - Bos taurus (Bovine) - GHRH gene GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. Indicus|evm.model.CM009503.1.687 Q8TBH0 ARRD2_HUMAN 73.946 0.928 0.614251 ARRDC2 - Arrestin domain-containing protein 2 - Homo sapiens (Human) - ARRDC2 gene cytoplasm, cytoplasmic vesicle, plasma membrane, protein transport Indicus|evm.model.CM009503.1.688 Q9NQG1 MANBL_HUMAN 93.243 0.848837 1.01176 MANBAL - Protein MANBAL - Homo sapiens (Human) - MANBAL gene Indicus|evm.model.CM009503.1.689 P12931 SRC_HUMAN 97.048 0.996317 1.01306 SRC - Proto-oncogene tyrosine-protein kinase Src - Homo sapiens (Human) - SRC gene Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Indicus|evm.model.CM009503.1.690 P62950 BLCAP_RAT 100.000 0.977273 1.01149 Blcap - Bladder cancer-associated protein - Rattus norvegicus (Rat) - Blcap gene May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. Indicus|evm.model.CM009503.1.691 Q0Q043 NNAT_PIG 100.000 0.97561 1.01235 NNAT - Neuronatin - Sus scrofa (Pig) - NNAT gene May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels (By similarity). Indicus|evm.model.CM009503.1.692 O62703 CTBL1_BOVIN 98.148 0.125296 0.751332 CTNNBL1 - Beta-catenin-like protein 1 - Bos taurus (Bovine) - CTNNBL1 gene Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR) (By similarity). Indicus|evm.model.CM009503.1.693 Q96N03 VTM2L_HUMAN 98.039 0.990244 1.0049 VSTM2L - V-set and transmembrane domain-containing protein 2-like protein precursor - Homo sapiens (Human) - VSTM2L gene axon, cytoplasm, extracellular region, plasma membrane, cell-cell adhesion mediator activity, axon guidance, dendrite self-avoidance, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of neuron apoptotic process Indicus|evm.model.CM009503.1.695 O43156 TTI1_HUMAN 85.165 0.99817 1.00367 TTI1 - TELO2-interacting protein 1 homolog - Homo sapiens (Human) - TTI1 gene Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. Indicus|evm.model.CM009503.1.696 Q9NQG5 RPR1B_HUMAN 100.000 0.993884 1.00307 RPRD1B - Regulation of nuclear pre-mRNA domain-containing protein 1B - Homo sapiens (Human) - RPRD1B gene Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. Indicus|evm.model.CM009503.1.697 P51176 TGM2_BOVIN 97.089 0.997015 0.975255 TGM2 - Protein-glutamine gamma-glutamyltransferase 2 - Bos taurus (Bovine) - TGM2 gene Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (By similarity). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:9880554). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:9880554). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (By similarity). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (By similarity). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (By similarity). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:25128524). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (By similarity). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (By similarity). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (By similarity). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (By similarity). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (By similarity). May also act as an isopeptidase cleaving the previously formed cross-links (By similarity). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (By similarity). Indicus|evm.model.CM009503.1.698 Q5JYT7 K1755_HUMAN 75.500 0.9925 1 KIAA1755 - Uncharacterized protein KIAA1755 - Homo sapiens (Human) - KIAA1755 gene Indicus|evm.model.CM009503.1.699 P17453 BPI_BOVIN 93.096 0.985537 1.00415 BPI - Bactericidal permeability-increasing protein precursor - Bos taurus (Bovine) - BPI gene The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Indicus|evm.model.CM009503.1.700 Q2TBI0 LBP_BOVIN 94.094 0.996071 1.05821 LBP - Lipopolysaccharide-binding protein precursor - Bos taurus (Bovine) - LBP gene Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide. Indicus|evm.model.CM009503.1.701 P18428 LBP_HUMAN 46.272 0.933476 0.968815 LBP - Lipopolysaccharide-binding protein precursor - Homo sapiens (Human) - LBP gene Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359). Indicus|evm.model.CM009503.1.703 Q86X10 RLGPB_HUMAN 97.659 0.998658 0.997323 RALGAPB - Ral GTPase-activating protein subunit beta - Homo sapiens (Human) - RALGAPB gene Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. Indicus|evm.model.CM009503.1.704 Q2EMW0 ADIG_BOVIN 100.000 0.97561 1.01235 ADIG - Adipogenin - Bos taurus (Bovine) - ADIG gene Plays a role in stimulating adipocyte differentiation and development. Indicus|evm.model.CM009503.1.705 O35458 VIAAT_RAT 99.240 0.996205 1.00381 Slc32a1 - Vesicular inhibitory amino acid transporter - Rattus norvegicus (Rat) - Slc32a1 gene Involved in the uptake of GABA and glycine into the synaptic vesicles. Indicus|evm.model.CM009503.1.706 Q9H9F9 ARP5_HUMAN 92.422 0.983766 1.01483 ACTR5 - Actin-related protein 5 - Homo sapiens (Human) - ACTR5 gene Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Indicus|evm.model.CM009503.1.708 Q95N27 PP16B_BOVIN 100.000 0.996485 1.00176 PPP1R16B - Protein phosphatase 1 regulatory inhibitor subunit 16B precursor - Bos taurus (Bovine) - PPP1R16B gene Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of the PI3K/AKT signaling pathway (By similarity). Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (PubMed:26806547). Involved in the regulation of endothelial cell filopodia extension (PubMed:17609201). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (By similarity). Involved in the dephosphorylation of EEF1A1 (By similarity). Indicus|evm.model.CM009503.1.709 A3KN19 FA83D_BOVIN 99.312 0.996564 1.00172 FAM83D - Protein FAM83D - Bos taurus (Bovine) - FAM83D gene Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22. Indicus|evm.model.CM009503.1.710 Q9H5Z1 DHX35_HUMAN 96.439 0.995739 1.00142 DHX35 - Probable ATP-dependent RNA helicase DHX35 - Homo sapiens (Human) - DHX35 gene May be involved in pre-mRNA splicing. Indicus|evm.model.CM009503.1.711 Q9Y5Q3 MAFB_HUMAN 98.142 0.993827 1.0031 MAFB - Transcription factor MafB - Homo sapiens (Human) - MAFB gene Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Indicus|evm.model.CM009503.1.712 Q7YR26 TOP1_CHLAE 98.309 0.997403 1.00391 TOP1 - DNA topoisomerase 1 - Chlorocebus aethiops (Green monkey) - TOP1 gene Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter. Indicus|evm.model.CM009503.1.713 P08487 PLCG1_BOVIN 98.383 0.949192 1.0062 PLCG1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 - Bos taurus (Bovine) - PLCG1 gene Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (By similarity). Indicus|evm.model.CM009503.1.714 Q9H4I2 ZHX3_HUMAN 82.322 0.997884 0.988494 ZHX3 - Zinc fingers and homeoboxes protein 3 - Homo sapiens (Human) - ZHX3 gene Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. Indicus|evm.model.CM009503.1.716 Q9BQK8 LPIN3_HUMAN 82.864 0.996479 1.00118 LPIN3 - Phosphatidate phosphatase LPIN3 - Homo sapiens (Human) - LPIN3 gene Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. Indicus|evm.model.CM009503.1.717 Q9NT22 EMIL3_HUMAN 85.373 0.990237 0.936031 EMILIN3 - EMILIN-3 precursor - Homo sapiens (Human) - EMILIN3 gene collagen-containing extracellular matrix, extracellular matrix constituent conferring elasticity, identical protein binding Indicus|evm.model.CM009503.1.718 Q8TD26 CHD6_HUMAN 88.473 0.999265 1.00258 CHD6 - Chromodomain-helicase-DNA-binding protein 6 - Homo sapiens (Human) - CHD6 gene DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. Indicus|evm.model.CM009503.1.720 Q5RCP8 H2B2E_PONAB 92.857 0.984252 1.00794 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009503.1.721 O14522 PTPRT_HUMAN 97.397 0.990207 0.637752 PTPRT - Receptor-type tyrosine-protein phosphatase T precursor - Homo sapiens (Human) - PTPRT gene May be involved in both signal transduction and cellular adhesion in the CNS. Indicus|evm.model.CM009503.1.722 O14522 PTPRT_HUMAN 99.265 0.642857 0.145732 PTPRT - Receptor-type tyrosine-protein phosphatase T precursor - Homo sapiens (Human) - PTPRT gene May be involved in both signal transduction and cellular adhesion in the CNS. Indicus|evm.model.CM009503.1.723 O14522 PTPRT_HUMAN 97.000 0.697183 0.0985427 PTPRT - Receptor-type tyrosine-protein phosphatase T precursor - Homo sapiens (Human) - PTPRT gene May be involved in both signal transduction and cellular adhesion in the CNS. Indicus|evm.model.CM009503.1.724 O14522 PTPRT_HUMAN 99.526 0.724138 0.201249 PTPRT - Receptor-type tyrosine-protein phosphatase T precursor - Homo sapiens (Human) - PTPRT gene May be involved in both signal transduction and cellular adhesion in the CNS. Indicus|evm.model.CM009503.1.725 Q13247 SRSF6_HUMAN 97.241 0.238843 3.51744 SRSF6 - Serine/arginine-rich splicing factor 6 - Homo sapiens (Human) - SRSF6 gene Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. Indicus|evm.model.CM009503.1.726 Q9HBY8 SGK2_HUMAN 96.185 0.994565 1.00272 SGK2 - Serine/threonine-protein kinase Sgk2 - Homo sapiens (Human) - SGK2 gene Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Indicus|evm.model.CM009503.1.727 Q62559 IFT52_MOUSE 93.048 0.914005 0.955399 Ift52 - Intraflagellar transport protein 52 homolog - Mus musculus (Mouse) - Ift52 gene Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia (PubMed:19253336). Required for the anterograde transport of IFT88 (By similarity). Indicus|evm.model.CM009503.1.728 P10244 MYBB_HUMAN 88.312 0.903947 1.08571 MYBL2 - Myb-related protein B - Homo sapiens (Human) - MYBL2 gene Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. Indicus|evm.model.CM009503.1.729 Q3T026 GTSFL_BOVIN 100.000 0.988235 1.00592 GTSF1L - Gametocyte-specific factor 1-like - Bos taurus (Bovine) - GTSF1L gene Indicus|evm.model.CM009503.1.730 Q76IQ7 TOX2_RAT 91.922 0.927461 0.816068 Tox2 - TOX high mobility group box family member 2 - Rattus norvegicus (Rat) - Tox2 gene Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system. Indicus|evm.model.CM009503.1.731 Q76IQ7 TOX2_RAT 95.789 0.671429 0.295983 Tox2 - TOX high mobility group box family member 2 - Rattus norvegicus (Rat) - Tox2 gene Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system. Indicus|evm.model.CM009503.1.732 Q9ET78 JPH2_MOUSE 100.000 0.0522876 0.659483 Jph2 - Junctophilin-2 - Mus musculus (Mouse) - Jph2 gene Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:10949023, PubMed:19095005, PubMed:21339484). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (PubMed:10949023, PubMed:19095005, PubMed:21339484). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (PubMed:10949023, PubMed:19095005, PubMed:21339484). Contributes to the construction of skeletal muscle triad junctions (PubMed:10949023). Indicus|evm.model.CM009503.1.733 Q5E9A0 OSER1_BOVIN 100.000 0.794521 1.2543 OSER1 - Oxidative stress-responsive serine-rich protein 1 - Bos taurus (Bovine) - OSER1 gene cellular response to hydrogen peroxide Indicus|evm.model.CM009503.1.734 Q96MZ0 GD1L1_HUMAN 98.365 0.994565 1.00272 GDAP1L1 - Ganglioside-induced differentiation-associated protein 1-like 1 - Homo sapiens (Human) - GDAP1L1 gene Indicus|evm.model.CM009503.1.735 A4IFN5 FITM2_BOVIN 100.000 0.992395 1.00382 FITM2 - Acyl-coenzyme A diphosphatase FITM2 - Bos taurus (Bovine) - FITM2 gene Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Indicus|evm.model.CM009503.1.737 A2A5I3 CRSPL_MOUSE 81.818 0.90942 1.09091 R3hdml - Peptidase inhibitor R3HDML precursor - Mus musculus (Mouse) - R3hdml gene Putative serine protease inhibitor. Indicus|evm.model.CM009503.1.738 P41235 HNF4A_HUMAN 95.570 0.995699 0.981013 HNF4A - Hepatocyte nuclear factor 4-alpha - Homo sapiens (Human) - HNF4A gene Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). Indicus|evm.model.CM009503.1.740 Q5RFR0 TTPAL_PONAB 91.813 0.994169 1.00292 TTPAL - Alpha-tocopherol transfer protein-like - Pongo abelii (Sumatran orangutan) - TTPAL gene May act as a protein that binds a hydrophobic ligand. Indicus|evm.model.CM009503.1.741 A4FUZ5 SERC3_BOVIN 100.000 0.995772 1.00212 SERINC3 - Serine incorporator 3 - Bos taurus (Bovine) - SERINC3 gene Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm. Indicus|evm.model.CM009503.1.742 Q7YQJ3 IPKG_BOVIN 98.684 0.714286 1.38158 PKIG - cAMP-dependent protein kinase inhibitor gamma - Bos taurus (Bovine) - PKIG gene Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Indicus|evm.model.CM009503.1.743 P56658 ADA_BOVIN 99.449 0.994505 1.00275 ADA - Adenosine deaminase - Bos taurus (Bovine) - ADA gene Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (By similarity). Plays an important role in purine metabolism and in adenosine homeostasis (By similarity). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity). Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (PubMed:23240012). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (By similarity). Indicus|evm.model.CM009503.1.744 O76076 CCN5_HUMAN 86.400 0.992032 1.004 CCN5 - CCN family member 5 precursor - Homo sapiens (Human) - CCN5 gene May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production. Indicus|evm.model.CM009503.1.745 Q8R5I0 KCNKF_RAT 81.040 0.993789 1.01258 Kcnk15 - Potassium channel subfamily K member 15 - Rattus norvegicus (Rat) - Kcnk15 gene Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel. Indicus|evm.model.CM009503.1.746 Q9H426 RIMS4_HUMAN 100.000 0.990783 0.806691 RIMS4 - Regulating synaptic membrane exocytosis protein 4 - Homo sapiens (Human) - RIMS4 gene Regulates synaptic membrane exocytosis. Indicus|evm.model.CM009503.1.747 A4K2U9 1433B_PONAB 100.000 0.991903 1.00407 YWHAB - 14-3-3 protein beta/alpha - Pongo abelii (Sumatran orangutan) - YWHAB gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. Indicus|evm.model.CM009503.1.748 Q4VXU2 PAP1L_HUMAN 87.765 0.98546 1.00814 PABPC1L - Polyadenylate-binding protein 1-like - Homo sapiens (Human) - PABPC1L gene cytoplasmic stress granule, cytosol, extracellular exosome, nucleus, ribonucleoprotein complex, mRNA 3'-UTR binding, poly(A) binding, poly(U) RNA binding, RNA binding Indicus|evm.model.CM009503.1.749 Q15785 TOM34_HUMAN 83.172 0.993548 1.00324 TOMM34 - Mitochondrial import receptor subunit TOM34 - Homo sapiens (Human) - TOMM34 gene Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. Indicus|evm.model.CM009503.1.750 Q5E9L6 STK4_BOVIN 100.000 0.995902 1.00205 STK4 - Serine/threonine-protein kinase 4 - Bos taurus (Bovine) - STK4 gene Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. Indicus|evm.model.CM009503.1.751 A4K2T1 KCNS1_MACMU 94.960 0.753507 0.943289 KCNS1 - Potassium voltage-gated channel subfamily S member 1 - Macaca mulatta (Rhesus macaque) - KCNS1 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Indicus|evm.model.CM009503.1.752 A4K2X5 WFDC5_SAIBB 74.380 0.983607 0.99187 WFDC5 - WAP four-disulfide core domain protein 5 precursor - Saimiri boliviensis boliviensis (Bolivian squirrel monkey) - WFDC5 gene Putative acid-stable proteinase inhibitor. Indicus|evm.model.CM009503.1.753 P22075 CALU_CAVPO 53.488 0.323077 2.36364 Caltrin-like protein 2 - Cavia porcellus (Guinea pig) Indicus|evm.model.CM009503.1.754 P22075 CALU_CAVPO 55.814 0.336 2.27273 Caltrin-like protein 2 - Cavia porcellus (Guinea pig) Indicus|evm.model.CM009503.1.755 P19957 ELAF_HUMAN 55.556 0.910448 1.1453 PI3 - Elafin precursor - Homo sapiens (Human) - PI3 gene Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648). Indicus|evm.model.CM009503.1.756 Q29125 ELAF_PIG 59.281 0.987097 0.928144 Elafin precursor - Sus scrofa (Pig) Indicus|evm.model.CM009503.1.757 P03973 SLPI_HUMAN 56.061 0.922535 1.07576 SLPI - Antileukoproteinase precursor - Homo sapiens (Human) - SLPI gene Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879). Indicus|evm.model.CM009503.1.758 Q6V9X0 SLPI_SHEEP 86.364 0.977444 1.00758 SLPI - Antileukoproteinase precursor - Ovis aries (Sheep) - SLPI gene Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (By similarity). Indicus|evm.model.CM009503.1.759 P62278 RS13_RAT 87.248 0.880952 1.11258 Rps13 - 40S ribosomal protein S13 - Rattus norvegicus (Rat) - Rps13 gene cytosolic small ribosomal subunit, nucleolus, nucleus, postsynaptic density, synapse, 5.8S rRNA binding, mRNA 5'-UTR binding, mRNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome Indicus|evm.model.CM009503.1.760 O95460 MATN4_HUMAN 85.690 0.936426 0.935691 MATN4 - Matrilin-4 precursor - Homo sapiens (Human) - MATN4 gene Major component of the extracellular matrix of cartilage. Indicus|evm.model.CM009503.1.761 Q9UBG7 RBPJL_HUMAN 87.406 0.996241 1.02901 RBPJL - Recombining binding protein suppressor of hairless-like protein - Homo sapiens (Human) - RBPJL gene Putative transcription factor, which cooperates with EBNA2 to activate transcription. Indicus|evm.model.CM009503.1.762 Q8HZJ6 SDC4_PIG 87.129 0.99 0.990099 SDC4 - Syndecan-4 precursor - Sus scrofa (Pig) - SDC4 gene Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Indicus|evm.model.CM009503.1.764 Q1RMQ3 SYS1_BOVIN 100.000 0.987261 1.00641 SYS1 - Protein SYS1 homolog - Bos taurus (Bovine) - SYS1 gene Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity). Indicus|evm.model.CM009503.1.765 Q9Y2B4 T53G5_HUMAN 57.752 0.96063 0.875862 TP53TG5 - TP53-target gene 5 protein - Homo sapiens (Human) - TP53TG5 gene May play a significant role in p53/TP53-mediating signaling pathway. Indicus|evm.model.CM009503.1.766 P30050 RL12_HUMAN 71.856 0.987179 0.945455 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Indicus|evm.model.CM009503.1.767 Q9CRD4 DBND2_MOUSE 82.609 0.987654 1.02532 Dbndd2 - Dysbindin domain-containing protein 2 - Mus musculus (Mouse) - Dbndd2 gene May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro) (By similarity). Indicus|evm.model.CM009503.1.768 Q969N2 PIGT_HUMAN 93.560 0.963731 1.00173 PIGT - GPI transamidase component PIG-T precursor - Homo sapiens (Human) - PIGT gene Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. Indicus|evm.model.CM009503.1.769 P00976 IBPC_BOVIN 90.625 0.155172 6.0597 Colostrum trypsin inhibitor - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.770 Q5PQQ2 WBP11_RAT 99.507 0.90583 0.347894 Wbp11 - WW domain-binding protein 11 - Rattus norvegicus (Rat) - Wbp11 gene Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity (By similarity). Indicus|evm.model.CM009503.1.771 P00975 IBPS_BOVIN 55.357 0.26699 3.43333 Serum basic protease inhibitor - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.772 P86862 VKT1_ANTEL 50.943 0.221277 3.61538 KappaPI-actitoxin-Ael3a - Anthopleura elegantissima (Green aggregating anemone) Indicus|evm.model.CM009503.1.774 Q29428 TKDP1_SHEEP 71.875 0.185629 0.630189 TKDP1 - Trophoblast Kunitz domain protein 1 precursor - Ovis aries (Sheep) - TKDP1 gene May play a role in mediating maternal-conceptus interactions in the immediate preimplantation period. Does not seem to have proteinase inhibitory activity. Indicus|evm.model.CM009503.1.775 P04815 BPT2_BOVIN 97.938 0.243038 3.95 Spleen trypsin inhibitor I precursor - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.776 Q08DY8 ATG13_BOVIN 91.736 0.442379 0.560417 ATG13 - Autophagy-related protein 13 - Bos taurus (Bovine) - ATG13 gene Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. Indicus|evm.model.CM009503.1.777 Q08DY8 ATG13_BOVIN 92.437 0.539171 0.452083 ATG13 - Autophagy-related protein 13 - Bos taurus (Bovine) - ATG13 gene Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. Indicus|evm.model.CM009503.1.778 Q28201 TKDP1_BOVIN 68.750 0.155 0.569801 TKDP1 - Trophoblast Kunitz domain protein 1 precursor - Bos taurus (Bovine) - TKDP1 gene May play a role in mediating maternal-conceptus interactions in the immediate preimplantation period. Does not seem to have proteinase inhibitory activity (By similarity). Indicus|evm.model.CM009503.1.779 P00974 BPT1_BOVIN 66.667 0.89 1 Pancreatic trypsin inhibitor precursor - Bos taurus (Bovine) Indicus|evm.model.CM009503.1.780 Q8MI69 WFDC2_PIG 76.423 0.983871 1.00813 WFDC2 - WAP four-disulfide core domain protein 2 precursor - Sus scrofa (Pig) - WFDC2 gene Broad range protease inhibitor. Indicus|evm.model.CM009503.1.781 Q9BDL1 EPPI_MACMU 61.000 0.332215 2.2406 EPPIN - Eppin precursor - Macaca mulatta (Rhesus macaque) - EPPIN gene Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity). Indicus|evm.model.CM009503.1.783 Q8IUB3 WF10B_HUMAN 54.386 0.273171 2.80822 WFDC10B - Protein WFDC10B precursor - Homo sapiens (Human) - WFDC10B gene extracellular space, serine-type endopeptidase inhibitor activity, antibacterial humoral response, innate immune response Indicus|evm.model.CM009503.1.784 D0VWQ3 RL18_CANLF 81.034 0.360759 0.840426 RPL18 - Ribosomal protein L18 - Canis lupus familiaris (Dog) - RPL18 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009503.1.785 Q8IUB2 WFDC3_HUMAN 88.372 0.429293 0.857143 WFDC3 - WAP four-disulfide core domain protein 3 precursor - Homo sapiens (Human) - WFDC3 gene extracellular space, serine-type endopeptidase inhibitor activity, antibacterial humoral response, innate immune response Indicus|evm.model.CM009503.1.786 A6H7A8 TDIF1_BOVIN 100.000 0.993939 1.00304 DNTTIP1 - Deoxynucleotidyltransferase terminal-interacting protein 1 - Bos taurus (Bovine) - DNTTIP1 gene Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. Indicus|evm.model.CM009503.1.787 Q32PA5 UBE2C_BOVIN 100.000 0.988889 1.00559 UBE2C - Ubiquitin-conjugating enzyme E2 C - Bos taurus (Bovine) - UBE2C gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Indicus|evm.model.CM009503.1.788 P02585 TNNC2_HUMAN 94.595 0.839695 0.81875 TNNC2 - Troponin C, skeletal muscle - Homo sapiens (Human) - TNNC2 gene Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Indicus|evm.model.CM009503.1.789 Q969T3 SNX21_HUMAN 85.714 0.398927 1.49866 SNX21 - Sorting nexin-21 - Homo sapiens (Human) - SNX21 gene Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking. Indicus|evm.model.CM009503.1.790 Q969T3 SNX21_HUMAN 90.000 0.940476 0.225201 SNX21 - Sorting nexin-21 - Homo sapiens (Human) - SNX21 gene Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking. Indicus|evm.model.CM009503.1.791 Q96MP5 ZSWM3_HUMAN 78.617 0.995153 0.889368 ZSWIM3 - Zinc finger SWIM domain-containing protein 3 - Homo sapiens (Human) - ZSWIM3 gene Indicus|evm.model.CM009503.1.793 Q9BR11 ZSWM1_HUMAN 81.140 0.995624 0.942268 ZSWIM1 - Zinc finger SWIM domain-containing protein 1 - Homo sapiens (Human) - ZSWIM1 gene Indicus|evm.model.CM009503.1.794 Q9BR10 SPT25_HUMAN 72.247 0.990868 0.964758 SPATA25 - Spermatogenesis-associated protein 25 - Homo sapiens (Human) - SPATA25 gene May play a role in spermatogenesis. Indicus|evm.model.CM009503.1.795 Q9BR09 NEUL2_HUMAN 93.333 0.993007 1.00351 NEURL2 - Neuralized-like protein 2 - Homo sapiens (Human) - NEURL2 gene Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity). Indicus|evm.model.CM009503.1.796 Q3MI05 PPGB_BOVIN 99.582 0.995833 1.00209 CTSA - Lysosomal protective protein precursor - Bos taurus (Bovine) - CTSA gene Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins (By similarity). Indicus|evm.model.CM009503.1.797 P55058 PLTP_HUMAN 90.021 0.965795 1.00811 PLTP - Phospholipid transfer protein precursor - Homo sapiens (Human) - PLTP gene Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves (PubMed:7654777, PubMed:9132017, PubMed:11013307, PubMed:19321130, PubMed:21515415, PubMed:29883800). Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine (PubMed:9132017). Plays an important role in HDL remodeling which involves modulating the size and composition of HDL (PubMed:29883800). Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion (PubMed:21736953). Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability (PubMed:11013307). Indicus|evm.model.CM009503.1.798 Q9H4Z3 CAPAM_HUMAN 96.733 0.874065 1.1392 PCIF1 - mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase - Homo sapiens (Human) - PCIF1 gene Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). Indicus|evm.model.CM009503.1.799 Q9H4Z2 ZN335_HUMAN 89.599 0.998511 1.00075 ZNF335 - Zinc finger protein 335 - Homo sapiens (Human) - ZNF335 gene Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). Indicus|evm.model.CM009503.1.800 P52176 MMP9_BOVIN 100.000 0.997195 1.0014 MMP9 - Matrix metalloproteinase-9 precursor - Bos taurus (Bovine) - MMP9 gene Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (By similarity). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (By similarity). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (By similarity). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide (By similarity). Indicus|evm.model.CM009503.1.801 Q9H2X9 S12A5_HUMAN 99.090 0.98299 0.980685 SLC12A5 - Solute carrier family 12 member 5 - Homo sapiens (Human) - SLC12A5 gene Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). Indicus|evm.model.CM009503.1.802 Q9HCD5 NCOA5_HUMAN 94.301 0.996552 1.00173 NCOA5 - Nuclear receptor coactivator 5 - Homo sapiens (Human) - NCOA5 gene Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). Indicus|evm.model.CM009503.1.804 Q28203 TNR5_BOVIN 100.000 0.992883 1.00357 CD40 - Tumor necrosis factor receptor superfamily member 5 precursor - Bos taurus (Bovine) - CD40 gene Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). Indicus|evm.model.CM009503.1.806 Q9UJ99 CAD22_HUMAN 95.839 0.953995 0.997585 CDH22 - Cadherin-22 precursor - Homo sapiens (Human) - CDH22 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity). Indicus|evm.model.CM009503.1.807 Q9NQQ7 S35C2_HUMAN 83.014 0.993769 0.879452 SLC35C2 - Solute carrier family 35 member C2 - Homo sapiens (Human) - SLC35C2 gene May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. Indicus|evm.model.CM009503.1.808 A4FUD6 ELMO2_BOVIN 99.861 0.997226 1.00139 ELMO2 - Engulfment and cell motility protein 2 - Bos taurus (Bovine) - ELMO2 gene Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). Indicus|evm.model.CM009503.1.809 A6NDX5 ZN840_HUMAN 66.267 0.980354 0.710894 ZNF840P - Putative zinc finger protein 840 - Homo sapiens (Human) - ZNF840P gene May be involved in transcriptional regulation. Indicus|evm.model.CM009503.1.810 O93603 TRFR_CHICK 54.599 0.901907 0.929114 TRHR - Thyrotropin-releasing hormone receptor - Gallus gallus (Chicken) - TRHR gene Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. Indicus|evm.model.CM009503.1.811 Q9BR26 OCSTP_HUMAN 75.817 0.966102 0.833922 OCSTAMP - Osteoclast stimulatory transmembrane protein - Homo sapiens (Human) - OCSTAMP gene Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity). Indicus|evm.model.CM009503.1.812 Q8WWT9 S13A3_HUMAN 89.037 0.996683 1.00166 SLC13A3 - Solute carrier family 13 member 3 - Homo sapiens (Human) - SLC13A3 gene High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including succinate, alpha-ketoglutarate and N-acetylaspartate (PubMed:30635937). The stoichiometry is probably 3 Na(+) for 1 divalent succinate. Indicus|evm.model.CM009503.1.814 Q96S44 PRPK_HUMAN 88.538 0.992126 1.00395 TP53RK - EKC/KEOPS complex subunit TP53RK - Homo sapiens (Human) - TP53RK gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). Indicus|evm.model.CM009503.1.815 O95528 GTR10_HUMAN 81.701 0.996276 0.992606 SLC2A10 - Solute carrier family 2, facilitated glucose transporter member 10 - Homo sapiens (Human) - SLC2A10 gene Facilitative glucose transporter required for the development of the cardiovascular system. Indicus|evm.model.CM009503.1.816 Q58DB6 EYA2_BOVIN 100.000 0.310606 0.73743 EYA2 - Eyes absent homolog 2 - Bos taurus (Bovine) - EYA2 gene Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. Indicus|evm.model.CM009503.1.818 Q9Y6Q9 NCOA3_HUMAN 89.238 0.998583 0.990871 NCOA3 - Nuclear receptor coactivator 3 - Homo sapiens (Human) - NCOA3 gene Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Indicus|evm.model.CM009503.1.819 Q8IWU5 SULF2_HUMAN 94.598 0.997691 0.995402 SULF2 - Extracellular sulfatase Sulf-2 precursor - Homo sapiens (Human) - SULF2 gene Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Indicus|evm.model.CM009503.1.821 P52732 KIF11_HUMAN 80.749 0.934066 0.172348 KIF11 - Kinesin-like protein KIF11 - Homo sapiens (Human) - KIF11 gene Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). Indicus|evm.model.CM009503.1.822 Q8TCU6 PREX1_HUMAN 93.707 0.998739 0.955998 PREX1 - Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein - Homo sapiens (Human) - PREX1 gene Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. Indicus|evm.model.CM009503.1.823 Q9Y6D5 BIG2_HUMAN 96.527 0.998876 0.997199 ARFGEF2 - Brefeldin A-inhibited guanine nucleotide-exchange protein 2 - Homo sapiens (Human) - ARFGEF2 gene Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Indicus|evm.model.CM009503.1.824 O46415 FRIL_BOVIN 98.734 0.975 0.457143 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009503.1.825 A5D785 XPO2_BOVIN 99.794 0.997942 1.00103 CSE1L - Exportin-2 - Bos taurus (Bovine) - CSE1L gene Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Indicus|evm.model.CM009503.1.826 O95793 STAU1_HUMAN 95.285 0.755952 1.16464 STAU1 - Double-stranded RNA-binding protein Staufen homolog 1 - Homo sapiens (Human) - STAU1 gene Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. Indicus|evm.model.CM009503.1.827 A1A4H6 DDX27_BOVIN 99.869 0.997389 1.00131 DDX27 - Probable ATP-dependent RNA helicase DDX27 - Bos taurus (Bovine) - DDX27 gene Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. Indicus|evm.model.CM009503.1.828 Q9P2E3 ZNFX1_HUMAN 88.698 0.998958 1.00052 ZNFX1 - NFX1-type zinc finger-containing protein 1 - Homo sapiens (Human) - ZNFX1 gene nuclear RNA-directed RNA polymerase complex, RNA binding, heterochromatin assembly by small RNA Indicus|evm.model.CM009503.1.829 O18868 KCNB1_PIG 97.885 0.996983 0.772727 KCNB1 - Potassium voltage-gated channel subfamily B member 1 - Sus scrofa (Pig) - KCNB1 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (By similarity). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Channel properties are also modulated by cytoplasmic ancillary beta subunits, such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus. Contributes to the regulation of the glucose-induced amplitude and duration of action potentials in pancreatic beta-cells, hence limiting calcium influx and insulin secretion. Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions. Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits. Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner. Indicus|evm.model.CM009503.1.830 Q14721 KCNB1_HUMAN 99.474 0.847534 0.259907 KCNB1 - Potassium voltage-gated channel subfamily B member 1 - Homo sapiens (Human) - KCNB1 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:8081723, PubMed:1283219, PubMed:10484328, PubMed:12560340, PubMed:19074135, PubMed:19717558, PubMed:24901643). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). Indicus|evm.model.CM009503.1.831 Q29626 PTGIS_BOVIN 99.800 0.996008 1.002 PTGIS - Prostacyclin synthase - Bos taurus (Bovine) - PTGIS gene Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:8051072, PubMed:8280118). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (By similarity). Indicus|evm.model.CM009503.1.833 A0A1S6M251 B4GT5_PIG 96.011 0.921053 0.979381 B4GALT5 - Beta-1,4-galactosyltransferase 5 - Sus scrofa (Pig) - B4GALT5 gene Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (By similarity). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity). Indicus|evm.model.CM009503.1.834 Q9Y2E8 SL9A8_HUMAN 97.059 0.99651 0.986231 SLC9A8 - Sodium/hydrogen exchanger 8 - Homo sapiens (Human) - SLC9A8 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Indicus|evm.model.CM009503.1.835 Q9UM82 SPAT2_HUMAN 85.465 0.446237 0.715385 SPATA2 - Spermatogenesis-associated protein 2 - Homo sapiens (Human) - SPATA2 gene Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity). Indicus|evm.model.CM009503.1.837 Q4U5R4 RN114_BOVIN 100.000 0.991342 1.00435 RNF114 - E3 ubiquitin-protein ligase RNF114 - Bos taurus (Bovine) - RNF114 gene E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. Indicus|evm.model.CM009503.1.838 O95863 SNAI1_HUMAN 87.500 0.992453 1.00379 SNAI1 - Zinc finger protein SNAI1 - Homo sapiens (Human) - SNAI1 gene Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. Indicus|evm.model.CM009503.1.839 Q13404 UB2V1_HUMAN 100.000 0.981132 0.721088 UBE2V1 - Ubiquitin-conjugating enzyme E2 variant 1 - Homo sapiens (Human) - UBE2V1 gene Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. Indicus|evm.model.CM009503.1.840 A6QLM0 PDES1_BOVIN 98.780 0.729167 1.23985 PEDS1 - Plasmanylethanolamine desaturase - Bos taurus (Bovine) - PEDS1 gene Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms. Indicus|evm.model.CM009503.1.842 P18031 PTN1_HUMAN 88.028 0.888889 1.07586 PTPN1 - Tyrosine-protein phosphatase non-receptor type 1 - Homo sapiens (Human) - PTPN1 gene Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. Indicus|evm.model.CM009503.1.843 Q96MK2 RIPR3_HUMAN 83.316 0.99789 1.00211 RIPOR3 - RIPOR family member 3 - Homo sapiens (Human) - RIPOR3 gene Indicus|evm.model.CM009503.1.844 Q9BYG5 PAR6B_HUMAN 89.008 0.994652 1.00538 PARD6B - Partitioning defective 6 homolog beta - Homo sapiens (Human) - PARD6B gene Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Indicus|evm.model.CM009503.1.845 Q8TDM0 BCAS4_HUMAN 74.167 0.72561 0.777251 BCAS4 - Breast carcinoma-amplified sequence 4 - Homo sapiens (Human) - BCAS4 gene BLOC-1 complex Indicus|evm.model.CM009503.1.846 Q9H2P0 ADNP_HUMAN 96.555 0.998187 1.00091 ADNP - Activity-dependent neuroprotector homeobox protein - Homo sapiens (Human) - ADNP gene Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Indicus|evm.model.CM009503.1.847 Q1JQ93 DPM1_BOVIN 98.846 0.992337 1.00385 DPM1 - Dolichol-phosphate mannosyltransferase subunit 1 - Bos taurus (Bovine) - DPM1 gene Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. Indicus|evm.model.CM009503.1.848 A1A4L8 MOCS3_BOVIN 99.780 0.970085 1.02857 MOCS3 - Adenylyltransferase and sulfurtransferase MOCS3 - Bos taurus (Bovine) - MOCS3 gene Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. Indicus|evm.model.CM009503.1.849 Q9UIX4 KCNG1_HUMAN 93.969 0.996117 1.0039 KCNG1 - Potassium voltage-gated channel subfamily G member 1 - Homo sapiens (Human) - KCNG1 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135). Indicus|evm.model.CM009503.1.850 Q13469 NFAC2_HUMAN 92.216 0.997824 0.993514 NFATC2 - Nuclear factor of activated T-cells, cytoplasmic 2 - Homo sapiens (Human) - NFATC2 gene Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. Indicus|evm.model.CM009503.1.851 O75110 ATP9A_HUMAN 97.949 0.980825 0.99618 ATP9A - Probable phospholipid-transporting ATPase IIA - Homo sapiens (Human) - ATP9A gene Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling and endosome to trans-Golgi network retrograde transport (PubMed:27733620, PubMed:30213940). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation (PubMed:30213940). Appears to be implicated in intercellular communication by negatively regulating the release of exosomes (PubMed:30947313). The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved (PubMed:30947313). Indicus|evm.model.CM009503.1.852 Q9UJQ4 SALL4_HUMAN 79.699 0.998117 1.00855 SALL4 - Sal-like protein 4 - Homo sapiens (Human) - SALL4 gene Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells. Indicus|evm.model.CM009503.1.855 Q9NTW7 ZF64B_HUMAN 86.486 0.95082 0.662016 ZFP64 - Zinc finger protein 64 - Homo sapiens (Human) - ZFP64 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009503.1.856 Q9NTW7 ZF64B_HUMAN 64.660 0.559524 1.04186 ZFP64 - Zinc finger protein 64 - Homo sapiens (Human) - ZFP64 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009503.1.859 Q9NRE2 TSH2_HUMAN 92.402 0.921402 1.02128 TSHZ2 - Teashirt homolog 2 - Homo sapiens (Human) - TSHZ2 gene Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Indicus|evm.model.CM009503.1.861 O75362 ZN217_HUMAN 70.509 0.995885 0.695611 ZNF217 - Zinc finger protein 217 - Homo sapiens (Human) - ZNF217 gene Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. Indicus|evm.model.CM009503.1.862 O75363 BCAS1_HUMAN 75.221 0.196837 0.974315 BCAS1 - Breast carcinoma-amplified sequence 1 - Homo sapiens (Human) - BCAS1 gene Required for myelination. Indicus|evm.model.CM009503.1.863 Q07973 CP24A_HUMAN 87.160 0.996117 1.00195 CYP24A1 - 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor - Homo sapiens (Human) - CYP24A1 gene A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:24893882, PubMed:15574355, PubMed:8679605, PubMed:11012668, PubMed:16617161, PubMed:29461981). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:24893882, PubMed:15574355). With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product (PubMed:11012668, PubMed:8679605). Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:8679605). Indicus|evm.model.CM009503.1.864 Q2TBR6 PFD4_BOVIN 98.425 0.851351 1.10448 PFDN4 - Prefoldin subunit 4 - Bos taurus (Bovine) - PFDN4 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Indicus|evm.model.CM009503.1.865 Q9P104 DOK5_HUMAN 83.007 0.99262 0.885621 DOK5 - Docking protein 5 - Homo sapiens (Human) - DOK5 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. Indicus|evm.model.CM009503.1.872 Q9NTU7 CBLN4_HUMAN 95.522 0.990099 1.00498 CBLN4 - Cerebellin-4 precursor - Homo sapiens (Human) - CBLN4 gene Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity). Essential for the formation and maintenance of inhibitory GABAergic synapses (By similarity). Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons (By similarity). May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors (By similarity). May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity). Indicus|evm.model.CM009504.1.1 Q13136 LIPA1_HUMAN 77.500 0.23125 0.133111 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009504.1.2 Q13136 LIPA1_HUMAN 82.500 0.258278 0.125624 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009504.1.3 Q13136 LIPA1_HUMAN 82.609 0.0920502 0.397671 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009504.1.4 Q9NPG1 FZD3_HUMAN 82.759 0.0858896 0.489489 FZD3 - Frizzled-3 precursor - Homo sapiens (Human) - FZD3 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity). Indicus|evm.model.CM009504.1.5 Q13136 LIPA1_HUMAN 72.727 0.966667 0.0748752 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009504.1.6 Q13136 LIPA1_HUMAN 51.327 0.549474 0.395175 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009504.1.7 Q8BSS9 LIPA2_MOUSE 81.818 0.0284192 0.895784 Ppfia2 - Liprin-alpha-2 - Mus musculus (Mouse) - Ppfia2 gene Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines. Indicus|evm.model.CM009504.1.8 Q21049 LIPA_CAEEL 67.692 0.255144 0.213345 syd-2 - Liprin-alpha - Caenorhabditis elegans - syd-2 gene May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse (PubMed:10517634, PubMed:19290026). This may be in association with the liprin-beta protein hlb-1 (PubMed:19290026). Indicus|evm.model.CM009504.1.9 Q8NGL4 OR5DD_HUMAN 71.233 0.863095 0.535032 OR5D13 - Olfactory receptor 5D13 - Homo sapiens (Human) - OR5D13 gene Odorant receptor. Indicus|evm.model.CM009504.1.10 Q9UPS8 ANR26_HUMAN 64.038 0.794118 0.616374 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009504.1.11 Q7TNU6 ZN250_MOUSE 78.505 0.884106 1.12897 Znf250 - Zinc finger protein 250 - Mus musculus (Mouse) - Znf250 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009504.1.12 A1YG88 ZNF16_PANPA 75.083 0.965232 0.897474 ZNF16 - Zinc finger protein 16 - Pan paniscus (Pygmy chimpanzee) - ZNF16 gene Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis (By similarity). Indicus|evm.model.CM009504.1.13 Q2KID8 CH033_BOVIN 99.415 0.78341 1.15426 UPF0488 protein C8orf33 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009504.1.14 A3KN32 ZNF34_BOVIN 100.000 0.996324 1.00184 ZNF34 - Zinc finger protein 34 - Bos taurus (Bovine) - ZNF34 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009504.1.15 P62919 RL8_RAT 100.000 0.992248 1.00389 Rpl8 - 60S ribosomal protein L8 - Rattus norvegicus (Rat) - Rpl8 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009504.1.16 P17097 ZNF7_HUMAN 79.826 0.965517 1.01458 ZNF7 - Zinc finger protein 7 - Homo sapiens (Human) - ZNF7 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009504.1.17 Q5E9K1 COMD5_BOVIN 100.000 0.991111 1.00446 COMMD5 - COMM domain-containing protein 5 - Bos taurus (Bovine) - COMMD5 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B. Indicus|evm.model.CM009504.1.19 P18890 RHG39_RAT 98.020 0.0809061 12.2376 Arhgap39 - Rho GTPase-activating protein 39 - Rattus norvegicus (Rat) - Arhgap39 gene cytoplasm, glutamatergic synapse, postsynapse, GTPase activator activity, postsynapse organization Indicus|evm.model.CM009504.1.20 A8E4L3 CH082_BOVIN 100.000 0.943478 1.05505 UPF0598 protein C8orf82 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009504.1.21 Q50LG9 LRC24_HUMAN 85.947 0.834483 1.1306 LRRC24 - Leucine-rich repeat-containing protein 24 precursor - Homo sapiens (Human) - LRRC24 gene extracellular matrix, extracellular space Indicus|evm.model.CM009504.1.22 A5PJJ5 LRC14_BOVIN 100.000 0.995951 1.00203 LRRC14 - Leucine-rich repeat-containing protein 14 - Bos taurus (Bovine) - LRRC14 gene Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB. Indicus|evm.model.CM009504.1.23 O94761 RECQ4_HUMAN 65.308 0.998359 1.00911 RECQL4 - ATP-dependent DNA helicase Q4 - Homo sapiens (Human) - RECQL4 gene DNA-dependent ATPase. May modulate chromosome segregation. Indicus|evm.model.CM009504.1.24 Q96ES6 MFSD3_HUMAN 77.129 0.987952 1.00728 MFSD3 - Major facilitator superfamily domain-containing protein 3 - Homo sapiens (Human) - MFSD3 gene solute:proton symporter activity Indicus|evm.model.CM009504.1.25 A4IFH5 ALAT1_BOVIN 100.000 0.488648 2.04234 GPT - Alanine aminotransferase 1 - Bos taurus (Bovine) - GPT gene Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). Indicus|evm.model.CM009504.1.26 O75593 FOXH1_HUMAN 81.744 0.99446 0.989041 FOXH1 - Forkhead box protein H1 - Homo sapiens (Human) - FOXH1 gene Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). Indicus|evm.model.CM009504.1.27 Q96AC6 KIFC2_HUMAN 83.853 0.822144 1.01313 KIFC2 - Kinesin-like protein KIFC2 - Homo sapiens (Human) - KIFC2 gene May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity). Indicus|evm.model.CM009504.1.28 Q6ZMK1 CYHR1_HUMAN 93.923 0.99449 1.00276 CYHR1 - Cysteine and histidine-rich protein 1 - Homo sapiens (Human) - CYHR1 gene nucleoplasm Indicus|evm.model.CM009504.1.29 Q0P5G1 TONSL_BOVIN 100.000 0.998545 1.00073 TONSL - Tonsoku-like protein - Bos taurus (Bovine) - TONSL gene Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). Indicus|evm.model.CM009504.1.30 Q3T178 VPS28_BOVIN 77.828 0.988506 0.78733 VPS28 - Vacuolar protein sorting-associated protein 28 homolog - Bos taurus (Bovine) - VPS28 gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Indicus|evm.model.CM009504.1.31 Q1KZG0 S39A4_BOVIN 100.000 0.996942 1.00153 SLC39A4 - Zinc transporter ZIP4 precursor - Bos taurus (Bovine) - SLC39A4 gene Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity). Indicus|evm.model.CM009504.1.32 Q10569 CPSF1_BOVIN 100.000 0.953734 1.04778 CPSF1 - Cleavage and polyadenylation specificity factor subunit 1 - Bos taurus (Bovine) - CPSF1 gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). Indicus|evm.model.CM009504.1.33 Q3MIX3 ADCK5_HUMAN 84.174 0.875 1.13103 ADCK5 - Uncharacterized aarF domain-containing protein kinase 5 - Homo sapiens (Human) - ADCK5 gene The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr). Indicus|evm.model.CM009504.1.34 Q863Y7 S52A2_PIG 85.650 0.995526 1.00224 SLC52A2 - Solute carrier family 52, riboflavin transporter, member 2 - Sus scrofa (Pig) - SLC52A2 gene Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. May also act as a receptor for 4-hydroxybutyrate. Indicus|evm.model.CM009504.1.35 Q8N531 FBXL6_HUMAN 84.586 0.942056 0.992579 FBXL6 - F-box/LRR-repeat protein 6 - Homo sapiens (Human) - FBXL6 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009504.1.36 Q2WGJ8 TM249_HUMAN 84.242 0.849741 0.821277 TMEM249 - Transmembrane protein 249 - Homo sapiens (Human) - TMEM249 gene Indicus|evm.model.CM009504.1.37 Q9BWW7 SCRT1_HUMAN 94.304 0.444759 1.01437 SCRT1 - Transcriptional repressor scratch 1 - Homo sapiens (Human) - SCRT1 gene Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation. Indicus|evm.model.CM009504.1.39 Q8MK44 DGAT1_BOVIN 89.366 0.995434 0.895706 DGAT1 - Diacylglycerol O-acyltransferase 1 - Bos taurus (Bovine) - DGAT1 gene Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:18704537). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats. In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (By similarity). Also present in female mammary glands, where it produces fat in the milk (PubMed:18704537, PubMed:15342525). May be involved in VLDL (very low density lipoprotein) assembly (By similarity). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (By similarity). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Indicus|evm.model.CM009504.1.40 Q08DJ8 HSF1_BOVIN 94.756 0.99639 1.05524 HSF1 - Heat shock factor protein 1 - Bos taurus (Bovine) - HSF1 gene Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes. Activation is reversible, and during the attenuation and recovery phase period of the heat shock response, returns to its unactivated form. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences. Binds to chromatin at heat shock gene promoters. Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner. Plays a role in nuclear export of stress-induced HSP70 mRNA. Plays a role in the regulation of mitotic progression. Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner. Involved in stress-induced cancer cell proliferation in a IER5-dependent manner. Indicus|evm.model.CM009504.1.41 Q14137 BOP1_HUMAN 84.973 0.997315 0.99866 BOP1 - Ribosome biogenesis protein BOP1 - Homo sapiens (Human) - BOP1 gene Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Indicus|evm.model.CM009504.1.42 A7E2Y6 MROH1_BOVIN 99.092 0.957895 1.03511 MROH1 - Maestro heat-like repeat-containing protein family member 1 - Bos taurus (Bovine) - MROH1 gene Indicus|evm.model.CM009504.1.43 Q8C1R0 TSSK5_MOUSE 81.877 0.855556 0.967742 Tssk5 - Testis-specific serine/threonine-protein kinase 5 - Mus musculus (Mouse) - Tssk5 gene May be involved in a signaling pathway during male germ cell development or mature sperm function. Indicus|evm.model.CM009504.1.44 Q9BTY7 HGH1_HUMAN 84.777 0.984456 0.989744 HGH1 - Protein HGH1 homolog - Homo sapiens (Human) - HGH1 gene Indicus|evm.model.CM009504.1.45 A6NE52 WDR97_HUMAN 72.386 0.246011 0.92725 WDR97 - WD repeat-containing protein 97 - Homo sapiens (Human) - WDR97 gene Indicus|evm.model.CM009504.1.46 A5D9C6 MAF1_BOVIN 100.000 0.992337 1.00385 MAF1 - Repressor of RNA polymerase III transcription MAF1 homolog - Bos taurus (Bovine) - MAF1 gene Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (By similarity). Plays also a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB. When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout. Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (By similarity). Indicus|evm.model.CM009504.1.48 E1BDF2 SHRPN_BOVIN 100.000 0.995122 1.00244 SHARPIN - Sharpin - Bos taurus (Bovine) - SHARPIN gene Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Indicus|evm.model.CM009504.1.49 P00125 CY1_BOVIN 100.000 0.993865 1.00308 CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Bos taurus (Bovine) - CYC1 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c. Indicus|evm.model.CM009504.1.50 O43292 GPAA1_HUMAN 91.787 0.996759 0.993559 GPAA1 - Glycosylphosphatidylinositol anchor attachment 1 protein - Homo sapiens (Human) - GPAA1 gene Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. Indicus|evm.model.CM009504.1.51 Q7YRA3 EXOS4_BOVIN 100.000 0.99187 1.00408 EXOSC4 - Exosome complex component RRP41 - Bos taurus (Bovine) - EXOSC4 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs (By similarity). Indicus|evm.model.CM009504.1.52 Q75WB5 OPLA_BOVIN 96.937 0.93015 1.08929 OPLAH - 5-oxoprolinase - Bos taurus (Bovine) - OPLAH gene Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Indicus|evm.model.CM009504.1.53 D6MZJ6 NSMA5_MOUSE 68.094 0.983122 0.981366 Smpd5 - Sphingomyelin phosphodiesterase 5 - Mus musculus (Mouse) - Smpd5 gene Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. Indicus|evm.model.CM009504.1.54 Q148B6 SPERI_MOUSE 84.615 0.315447 1.28125 Spatc1 - Speriolin - Mus musculus (Mouse) - Spatc1 gene centrosome, cytoplasm, gamma-tubulin binding Indicus|evm.model.CM009504.1.55 Q32L53 LFG1_BOVIN 100.000 0.933504 1.06831 GRINA - Protein lifeguard 1 - Bos taurus (Bovine) - GRINA gene Potential apoptotic regulator. Indicus|evm.model.CM009504.1.56 Q53GL7 PAR10_HUMAN 65.885 0.992693 0.934634 PARP10 - Protein mono-ADP-ribosyltransferase PARP10 - Homo sapiens (Human) - PARP10 gene ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737). Indicus|evm.model.CM009504.1.57 Q15149 PLEC_HUMAN 91.929 0.983657 0.966695 PLEC - Plectin - Homo sapiens (Human) - PLEC gene Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. Indicus|evm.model.CM009504.1.58 P58107 EPIPL_HUMAN 93.175 0.0816723 0.808569 EPPK1 - Epiplakin - Homo sapiens (Human) - EPPK1 gene Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity). Indicus|evm.model.CM009504.1.59 Q91V36 NRBP2_MOUSE 93.574 0.993964 0.995992 Nrbp2 - Nuclear receptor-binding protein 2 - Mus musculus (Mouse) - Nrbp2 gene May regulate apoptosis of neural progenitor cells during their differentiation. Indicus|evm.model.CM009504.1.60 Q2HJG2 PUF60_BOVIN 99.808 0.9254 1.06226 PUF60 - Poly(U)-binding-splicing factor PUF60 - Bos taurus (Bovine) - PUF60 gene DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA (By similarity). Indicus|evm.model.CM009504.1.61 Q80U72 SCRIB_MOUSE 90.064 0.537133 1.07754 Scrib - Protein scribble homolog - Mus musculus (Mouse) - Scrib gene Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:12499390, PubMed:18716323, PubMed:19041750, PubMed:18329370). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (PubMed:18329370). Most probably functions in the establishment of apico-basal cell polarity (PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:19041750). May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:19458197). Functions as an activator of Rac GTPase activity. Indicus|evm.model.CM009504.1.62 A8MXQ7 IQAK1_HUMAN 73.064 0.996622 1.05714 IQANK1 - IQ motif and ankyrin repeat domain-containing protein 1 - Homo sapiens (Human) - IQANK1 gene cytoplasm, nucleus, regulation of barbed-end actin filament capping Indicus|evm.model.CM009504.1.63 Q6ZRV2 FA83H_HUMAN 86.160 0.998308 1.00254 FAM83H - Protein FAM83H - Homo sapiens (Human) - FAM83H gene May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). Indicus|evm.model.CM009504.1.64 Q9Z2A6 MK15_RAT 71.509 0.971537 0.963437 Mapk15 - Mitogen-activated protein kinase 15 - Rattus norvegicus (Rat) - Mapk15 gene Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner. Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation. Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins. Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion. Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA. Regulates DA transporter (DAT) activity and protein expression via activation of RhoA. In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (By similarity). Also functions in a kinase activity-independent manner as a negative regulator of growth (PubMed:9891064). Phosphorylates in vitro FOS and MBP (PubMed:11875070). During oocyte maturation, plays a key role in the microtubule organization and mei- otic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (By similarity). Indicus|evm.model.CM009504.1.65 O75123 ZN623_HUMAN 80.933 0.991919 0.923507 ZNF623 - Zinc finger protein 623 - Homo sapiens (Human) - ZNF623 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009504.1.66 A3KN32 ZNF34_BOVIN 51.799 0.408284 0.622468 ZNF34 - Zinc finger protein 34 - Bos taurus (Bovine) - ZNF34 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009504.1.67 Q8K3X2 FCL_CRIGR 93.458 0.76555 1.30218 GFUS - GDP-L-fucose synthase - Cricetulus griseus (Chinese hamster) - GFUS gene Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Indicus|evm.model.CM009504.1.68 Q58D08 P5CR3_BOVIN 100.000 0.993528 1.00325 PYCR3 - Pyrroline-5-carboxylate reductase 3 - Bos taurus (Bovine) - PYCR3 gene Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. Indicus|evm.model.CM009504.1.69 G3MY25 TIGD5_BOVIN 93.182 0.961279 0.923795 TIGD5 - Tigger transposable element-derived protein 5 - Bos taurus (Bovine) - TIGD5 gene nucleus, DNA binding Indicus|evm.model.CM009504.1.70 A5D989 EF1D_BOVIN 100.000 0.422727 2.35714 EEF1D - Elongation factor 1-delta - Bos taurus (Bovine) - EEF1D gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Indicus|evm.model.CM009504.1.71 A5PK51 PNCB_BOVIN 99.814 0.996289 1.00186 NAPRT - Nicotinate phosphoribosyltransferase - Bos taurus (Bovine) - NAPRT gene Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis. Indicus|evm.model.CM009504.1.72 A6NGR9 MROH6_HUMAN 79.034 0.99572 0.974965 MROH6 - Maestro heat-like repeat-containing protein family member 6 - Homo sapiens (Human) - MROH6 gene Indicus|evm.model.CM009504.1.73 P57764 GSDMD_HUMAN 64.330 0.991786 1.0062 GSDMD - Gasdermin-D - Homo sapiens (Human) - GSDMD gene Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216). Indicus|evm.model.CM009504.1.74 Q8IXZ2 ZC3H3_HUMAN 74.255 0.938272 0.939873 ZC3H3 - Zinc finger CCCH domain-containing protein 3 - Homo sapiens (Human) - ZC3H3 gene Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity). Indicus|evm.model.CM009504.1.75 D3ZNT6 MAFA_RAT 97.744 0.605505 0.603878 Mafa - Transcription factor MafA - Rattus norvegicus (Rat) - Mafa gene Transcription factor that activates insulin gene expression (PubMed:15665000). Acts synergistically with NEUROD1/BETA2 and PDX1 (By similarity). Binds the insulin enhancer C1/RIPE3b element (PubMed:15665000). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity). Indicus|evm.model.CM009504.1.77 Q8TCX5 RHPN1_HUMAN 74.313 0.990228 0.916418 RHPN1 - Rhophilin-1 - Homo sapiens (Human) - RHPN1 gene Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules. Indicus|evm.model.CM009504.1.78 Q969P6 TOP1M_HUMAN 52.553 0.852632 0.47421 TOP1MT - DNA topoisomerase I, mitochondrial precursor - Homo sapiens (Human) - TOP1MT gene Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Indicus|evm.model.CM009504.1.79 Q969P6 TOP1M_HUMAN 66.279 0.875 0.159734 TOP1MT - DNA topoisomerase I, mitochondrial precursor - Homo sapiens (Human) - TOP1MT gene Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Indicus|evm.model.CM009504.1.81 P10075 GLI4_HUMAN 76.667 0.690519 1.4867 GLI4 - Zinc finger protein GLI4 - Homo sapiens (Human) - GLI4 gene DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription, DNA-templated Indicus|evm.model.CM009504.1.82 Q9D1N2 HDBP1_MOUSE 54.861 0.80814 0.754386 Gpihbp1 - Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 precursor - Mus musculus (Mouse) - Gpihbp1 gene Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (PubMed:20620994). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (PubMed:20620994, PubMed:24726386, PubMed:27811232). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:17403372). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:18340083). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (PubMed:12496272). Indicus|evm.model.CM009504.1.83 A0JNB3 LY6H_BOVIN 99.286 0.985816 1.00714 LY6H - Lymphocyte antigen 6H precursor - Bos taurus (Bovine) - LY6H gene plasma membrane, acetylcholine receptor binding, acetylcholine receptor inhibitor activity, acetylcholine receptor signaling pathway Indicus|evm.model.CM009504.1.84 H3BQJ8 LY6L_HUMAN 51.282 0.834532 1.00725 LY6L - Lymphocyte antigen 6L precursor - Homo sapiens (Human) - LY6L gene plasma membrane Indicus|evm.model.CM009504.1.85 Q16553 LY6E_HUMAN 70.229 0.984733 1 LY6E - Lymphocyte antigen 6E precursor - Homo sapiens (Human) - LY6E gene GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482). Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity). Indicus|evm.model.CM009504.1.86 P15150 C11B1_BOVIN 97.813 0.996032 1.00199 CYP11B1 - Cytochrome P450 11B1, mitochondrial precursor - Bos taurus (Bovine) - CYP11B1 gene A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Indicus|evm.model.CM009504.1.88 P15150 C11B1_BOVIN 99.293 0.805714 0.695825 CYP11B1 - Cytochrome P450 11B1, mitochondrial precursor - Bos taurus (Bovine) - CYP11B1 gene A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Indicus|evm.model.CM009504.1.91 Q148C3 LY6D_BOVIN 99.219 0.984496 1.00781 LY6D - Lymphocyte antigen 6D precursor - Bos taurus (Bovine) - LY6D gene May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification (By similarity). Indicus|evm.model.CM009504.1.92 Q1RMQ4 LYNX1_BOVIN 100.000 0.982906 1.00862 LYNX1 - Ly-6/neurotoxin-like protein 1 precursor - Bos taurus (Bovine) - LYNX1 gene Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR. In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs. Prevents plasticity in the primary visual cortex late in life. Indicus|evm.model.CM009504.1.93 Q6UXB3 LYPD2_HUMAN 79.439 0.821705 1.032 LYPD2 - Ly6/PLAUR domain-containing protein 2 precursor - Homo sapiens (Human) - LYPD2 gene extracellular region, plasma membrane Indicus|evm.model.CM009504.1.94 P55000 SLUR1_HUMAN 65.306 0.76378 1.23301 SLURP1 - Secreted Ly-6/uPAR-related protein 1 precursor - Homo sapiens (Human) - SLURP1 gene Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have an immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896). Indicus|evm.model.CM009504.1.95 A6H707 THEM6_BOVIN 100.000 0.990431 1.00481 THEM6 - Protein THEM6 precursor - Bos taurus (Bovine) - THEM6 gene Indicus|evm.model.CM009504.1.96 O43653 PSCA_HUMAN 56.818 0.669565 1.00877 PSCA - Prostate stem cell antigen precursor - Homo sapiens (Human) - PSCA gene May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. Indicus|evm.model.CM009504.1.97 O75564 JERKY_HUMAN 70.433 0.928166 0.951439 JRK - Jerky protein homolog - Homo sapiens (Human) - JRK gene May bind DNA. Indicus|evm.model.CM009504.1.99 Q7LC44 ARC_HUMAN 91.667 0.994962 1.00253 ARC - Activity-regulated cytoskeleton-associated protein - Homo sapiens (Human) - ARC gene Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity). Indicus|evm.model.CM009504.1.102 O14514 AGRB1_HUMAN 92.424 0.0850785 0.964646 ADGRB1 - Adhesion G protein-coupled receptor B1 precursor - Homo sapiens (Human) - ADGRB1 gene Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720). Indicus|evm.model.CM009504.1.104 Q96NA8 TSNA1_HUMAN 77.432 0.995976 0.968811 TSNARE1 - t-SNARE domain-containing protein 1 - Homo sapiens (Human) - TSNARE1 gene endomembrane system, integral component of membrane, SNARE complex, SNAP receptor activity, SNARE binding, intracellular protein transport, vesicle docking, vesicle fusion Indicus|evm.model.CM009504.1.109 Q6ZUA9 MROH5_HUMAN 76.923 0.708333 0.0546282 MROH5 - Maestro heat-like repeat family member 5 - Homo sapiens (Human) - MROH5 gene Indicus|evm.model.CM009504.1.110 Q6ZUA9 MROH5_HUMAN 69.419 0.839378 0.292868 MROH5 - Maestro heat-like repeat family member 5 - Homo sapiens (Human) - MROH5 gene Indicus|evm.model.CM009504.1.111 A2VDT1 TP4A3_BOVIN 100.000 0.988506 1.00578 PTP4A3 - Protein tyrosine phosphatase type IVA 3 precursor - Bos taurus (Bovine) - PTP4A3 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II (By similarity). Indicus|evm.model.CM009504.1.113 Q99678 GPR20_HUMAN 83.934 0.994475 1.01117 GPR20 - G-protein coupled receptor 20 - Homo sapiens (Human) - GPR20 gene Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP. Indicus|evm.model.CM009504.1.115 Q5BKX6 S45A4_HUMAN 80.357 0.997416 1.00781 SLC45A4 - Solute carrier family 45 member 4 - Homo sapiens (Human) - SLC45A4 gene membrane, sucrose:proton symporter activity, sucrose transport Indicus|evm.model.CM009504.1.116 A2RUS2 DEND3_HUMAN 80.150 0.944182 1.06177 DENND3 - DENN domain-containing protein 3 - Homo sapiens (Human) - DENND3 gene Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). Indicus|evm.model.CM009504.1.117 Q05397 FAK1_HUMAN 92.490 0.843121 1.13308 PTK2 - Focal adhesion kinase 1 - Homo sapiens (Human) - PTK2 gene Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. Indicus|evm.model.CM009504.1.119 Q6QME8 AGO2_BOVIN 99.883 0.877446 1.12907 AGO2 - Protein argonaute-2 - Bos taurus (Bovine) - AGO2 gene Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. Indicus|evm.model.CM009504.1.120 Q9NRG0 CHRC1_HUMAN 85.496 0.984848 1.00763 CHRAC1 - Chromatin accessibility complex protein 1 - Homo sapiens (Human) - CHRAC1 gene Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Indicus|evm.model.CM009504.1.121 Q32PH0 TPPC9_BOVIN 97.376 0.941392 0.959578 TRAPPC9 - Trafficking protein particle complex subunit 9 - Bos taurus (Bovine) - TRAPPC9 gene Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. Indicus|evm.model.CM009504.1.123 Q9NPC2 KCNK9_HUMAN 98.947 0.949495 0.264706 KCNK9 - Potassium channel subfamily K member 9 - Homo sapiens (Human) - KCNK9 gene pH-dependent, voltage-insensitive, background potassium channel protein. Indicus|evm.model.CM009504.1.124 Q9NPC2 KCNK9_HUMAN 94.265 0.542969 1.36898 KCNK9 - Potassium channel subfamily K member 9 - Homo sapiens (Human) - KCNK9 gene pH-dependent, voltage-insensitive, background potassium channel protein. Indicus|evm.model.CM009504.1.125 Q8NFW1 COMA1_HUMAN 85.507 0.0436737 0.957565 COL22A1 - Collagen alpha-1(XXII) chain precursor - Homo sapiens (Human) - COL22A1 gene Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. Indicus|evm.model.CM009504.1.128 Q49AJ0 F135B_HUMAN 88.172 0.0736589 0.888336 FAM135B - Protein FAM135B - Homo sapiens (Human) - FAM135B gene cellular lipid metabolic process Indicus|evm.model.CM009504.1.131 O75525 KHDR3_HUMAN 97.476 0.9875 0.924855 KHDRBS3 - KH domain-containing, RNA-binding, signal transduction-associated protein 3 - Homo sapiens (Human) - KHDRBS3 gene RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Indicus|evm.model.CM009504.1.133 Q9P243 ZFAT_HUMAN 85.325 0.998384 0.995977 ZFAT - Zinc finger protein ZFAT - Homo sapiens (Human) - ZFAT gene May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). Indicus|evm.model.CM009504.1.134 Q02745 SIA4A_PIG 89.538 0.952941 0.991254 ST3GAL1 - CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 - Sus scrofa (Pig) - ST3GAL1 gene A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:19820709, PubMed:8288606). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:19820709, PubMed:8288606). Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans (PubMed:19820709, PubMed:8288606). As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (By similarity). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8288606). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8288606) (By similarity). Indicus|evm.model.CM009504.1.135 Q3SYX0 NDRG1_BOVIN 99.479 0.994805 1.0026 NDRG1 - Protein NDRG1 - Bos taurus (Bovine) - NDRG1 gene Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity). Indicus|evm.model.CM009504.1.136 O95388 CCN4_HUMAN 72.911 0.778068 1.0436 CCN4 - CCN family member 4 precursor - Homo sapiens (Human) - CCN4 gene Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. Indicus|evm.model.CM009504.1.137 P01267 THYG_BOVIN 100.000 0.580645 0.0671723 TG - Thyroglobulin precursor - Bos taurus (Bovine) - TG gene Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity). Indicus|evm.model.CM009504.1.138 P01267 THYG_BOVIN 99.324 0.794595 0.0668111 TG - Thyroglobulin precursor - Bos taurus (Bovine) - TG gene Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity). Indicus|evm.model.CM009504.1.139 P01267 THYG_BOVIN 98.140 0.710963 0.108704 TG - Thyroglobulin precursor - Bos taurus (Bovine) - TG gene Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity). Indicus|evm.model.CM009504.1.140 Q13239 SLAP1_HUMAN 91.304 0.870253 1.14493 SLA - Src-like-adapter - Homo sapiens (Human) - SLA gene Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Indicus|evm.model.CM009504.1.141 P01267 THYG_BOVIN 97.712 0.99588 0.87649 TG - Thyroglobulin precursor - Bos taurus (Bovine) - TG gene Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity). Indicus|evm.model.CM009504.1.142 A8MW92 P20L1_HUMAN 91.078 0.997984 0.975418 PHF20L1 - PHD finger protein 20-like protein 1 - Homo sapiens (Human) - PHF20L1 gene NSL complex, histone acetylation, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009504.1.143 Q6P5X7 TMM71_HUMAN 70.134 0.993289 1.01017 TMEM71 - Transmembrane protein 71 - Homo sapiens (Human) - TMEM71 gene mitochondrion Indicus|evm.model.CM009504.1.144 Q1RMR5 TILB_BOVIN 99.154 0.995781 1.00424 DNAAF11 - Dynein axonemal assembly factor 11 - Bos taurus (Bovine) - DNAAF11 gene Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia. Acts as a crucial component in the formation and motility of spermatozoal flagella. Indicus|evm.model.CM009504.1.145 O43525 KCNQ3_HUMAN 100.000 0.853933 0.102064 KCNQ3 - Potassium voltage-gated channel subfamily KQT member 3 - Homo sapiens (Human) - KCNQ3 gene Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. Indicus|evm.model.CM009504.1.147 P58126 KCNQ3_BOVIN 99.865 0.981383 0.86836 KCNQ3 - Potassium voltage-gated channel subfamily KQT member 3 - Bos taurus (Bovine) - KCNQ3 gene Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. Indicus|evm.model.CM009504.1.148 C9JL84 HHLA1_HUMAN 70.556 0.996296 1.01695 HHLA1 - HERV-H LTR-associating protein 1 precursor - Homo sapiens (Human) - HHLA1 gene Indicus|evm.model.CM009504.1.149 Q02509 OC90_HUMAN 70.528 0.991837 1.02725 OC90 - Otoconin-90 precursor - Homo sapiens (Human) - OC90 gene Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity. Indicus|evm.model.CM009504.1.150 Q14156 EFR3A_HUMAN 97.211 0.652742 0.466504 EFR3A - Protein EFR3 homolog A - Homo sapiens (Human) - EFR3A gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). Indicus|evm.model.CM009504.1.151 Q14156 EFR3A_HUMAN 92.026 0.697428 0.805116 EFR3A - Protein EFR3 homolog A - Homo sapiens (Human) - EFR3A gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). Indicus|evm.model.CM009504.1.152 Q3T160 NPM_BOVIN 81.667 0.946502 0.826531 NPM1 - Nucleophosmin - Bos taurus (Bovine) - NPM1 gene Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Indicus|evm.model.CM009504.1.153 P40145 ADCY8_HUMAN 97.526 0.8 1.251 ADCY8 - Adenylate cyclase type 8 - Homo sapiens (Human) - ADCY8 gene Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells. Indicus|evm.model.CM009504.1.154 Q6Q311 RS25_SHEEP 86.076 0.795918 0.784 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Indicus|evm.model.CM009504.1.155 Q21049 LIPA_CAEEL 64.103 0.0940594 0.354697 syd-2 - Liprin-alpha - Caenorhabditis elegans - syd-2 gene May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse (PubMed:10517634, PubMed:19290026). This may be in association with the liprin-beta protein hlb-1 (PubMed:19290026). Indicus|evm.model.CM009504.1.156 O97902 ASAP1_BOVIN 99.639 0.998193 0.980514 ASAP1 - Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 - Bos taurus (Bovine) - ASAP1 gene Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. Plays a role in ciliogenesis (By similarity). May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Indicus|evm.model.CM009504.1.157 Q9NUQ9 CYRIB_HUMAN 96.914 0.836788 1.19136 CYRIB - CYFIP-related Rac1 interactor B - Homo sapiens (Human) - CYRIB gene Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). Indicus|evm.model.CM009504.1.158 Q9BYG8 GSDMC_HUMAN 46.154 0.263699 0.574803 GSDMC - Gasdermin-C - Homo sapiens (Human) - GSDMC gene This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death. Indicus|evm.model.CM009504.1.159 Q9BYG8 GSDMC_HUMAN 52.148 0.995902 0.96063 GSDMC - Gasdermin-C - Homo sapiens (Human) - GSDMC gene This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death. Indicus|evm.model.CM009504.1.164 Q2HJ27 MYC_BOVIN 100.000 0.995455 1.00228 MYC - Myc proto-oncogene protein - Bos taurus (Bovine) - MYC gene Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Indicus|evm.model.CM009504.1.166 Q8CIP4 MARK4_MOUSE 51.899 0.804348 0.12234 Mark4 - MAP/microtubule affinity-regulating kinase 4 - Mus musculus (Mouse) - Mark4 gene Serine/threonine-protein kinase (By similarity). Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (By similarity). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (By similarity). Required for the initiation of axoneme extension during cilium assembly (By similarity). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (By similarity). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (By similarity). Reduces neuronal cell survival (By similarity). Plays a role in energy homeostasis by regulating satiety and metabolic rate (PubMed:22992738). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (PubMed:24989893). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (By similarity). Indicus|evm.model.CM009504.1.167 O08679 MARK2_RAT 52.941 0.377143 0.242382 Mark2 - Serine/threonine-protein kinase MARK2 - Rattus norvegicus (Rat) - Mark2 gene Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Indicus|evm.model.CM009504.1.169 Q8VHF0 MARK3_RAT 57.895 0.358974 0.195734 Mark3 - MAP/microtubule affinity-regulating kinase 3 - Rattus norvegicus (Rat) - Mark3 gene Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Indicus|evm.model.CM009504.1.170 O08679 MARK2_RAT 61.905 0.0764273 1.50416 Mark2 - Serine/threonine-protein kinase MARK2 - Rattus norvegicus (Rat) - Mark2 gene Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Indicus|evm.model.CM009504.1.172 O08678 MARK1_RAT 65.686 0.138546 0.919294 Mark1 - Serine/threonine-protein kinase MARK1 - Rattus norvegicus (Rat) - Mark1 gene Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (PubMed:14517247, PubMed:14741102, PubMed:9108484). Indicus|evm.model.CM009504.1.173 O08679 MARK2_RAT 54.098 0.630342 0.648199 Mark2 - Serine/threonine-protein kinase MARK2 - Rattus norvegicus (Rat) - Mark2 gene Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Indicus|evm.model.CM009504.1.176 O08678 MARK1_RAT 58.389 0.986667 0.189155 Mark1 - Serine/threonine-protein kinase MARK1 - Rattus norvegicus (Rat) - Mark1 gene Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (PubMed:14517247, PubMed:14741102, PubMed:9108484). Indicus|evm.model.CM009504.1.178 Q96KN1 LRAT2_HUMAN 88.818 0.993631 1.0129 LRATD2 - Protein LRATD2 - Homo sapiens (Human) - LRATD2 gene cytoplasm, plasma membrane Indicus|evm.model.CM009504.1.180 Q5E995 RS6_BOVIN 80.952 0.992248 0.518072 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009504.1.181 Q96RU8 TRIB1_HUMAN 96.774 0.994638 1.00269 TRIB1 - Tribbles homolog 1 - Homo sapiens (Human) - TRIB1 gene Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797). Indicus|evm.model.CM009504.1.182 Q32KY9 NSE2_BOVIN 98.387 0.991968 1.00403 NSMCE2 - E3 SUMO-protein ligase NSE2 - Bos taurus (Bovine) - NSMCE2 gene E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression. Indicus|evm.model.CM009504.1.184 Q12768 WASC5_HUMAN 97.929 0.998276 1.00086 WASHC5 - WASH complex subunit 5 - Homo sapiens (Human) - WASHC5 gene Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666). Indicus|evm.model.CM009504.1.185 Q14534 ERG1_HUMAN 87.631 0.99651 0.998258 SQLE - Squalene monooxygenase - Homo sapiens (Human) - SQLE gene Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. Indicus|evm.model.CM009504.1.186 Q32KN0 ZN572_BOVIN 99.433 0.996226 1.00189 ZNF572 - Zinc finger protein 572 - Bos taurus (Bovine) - ZNF572 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009504.1.187 O43312 MTSS1_HUMAN 97.098 0.997365 1.0053 MTSS1 - Protein MTSS 1 - Homo sapiens (Human) - MTSS1 gene May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. Indicus|evm.model.CM009504.1.188 Q02369 NDUB9_BOVIN 100.000 0.988889 1.00559 NDUFB9 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 - Bos taurus (Bovine) - NDUFB9 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009504.1.189 Q148G4 TATD1_BOVIN 99.663 0.993289 1.00337 TATDN1 - Putative deoxyribonuclease TATDN1 - Bos taurus (Bovine) - TATDN1 gene Putative deoxyribonuclease. Indicus|evm.model.CM009504.1.190 Q5RBT7 RN139_PONAB 95.789 0.996997 1.00301 RNF139 - E3 ubiquitin-protein ligase RNF139 - Pongo abelii (Sumatran orangutan) - RNF139 gene E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Involved in the sterol-accelerated degradation of HMGCR. This is achieved through binding to INSIG1 and/or INSIG2 at the ER membrane. In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. Indicus|evm.model.CM009504.1.191 Q58D65 TYW2_BOVIN 99.543 0.943844 1.05708 TRMT12 - tRNA wybutosine-synthesizing protein 2 homolog - Bos taurus (Bovine) - TRMT12 gene S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity). Indicus|evm.model.CM009504.1.192 Q2WGJ9 FR1L6_HUMAN 89.409 0.929465 1.07647 FER1L6 - Fer-1-like protein 6 - Homo sapiens (Human) - FER1L6 gene plasma membrane organization Indicus|evm.model.CM009504.1.193 Q658Y4 F91A1_HUMAN 95.823 0.997616 1.00119 FAM91A1 - Protein FAM91A1 - Homo sapiens (Human) - FAM91A1 gene As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. Indicus|evm.model.CM009504.1.194 Q29471 ANX13_CANLF 87.654 0.993846 1.02848 ANXA13 - Annexin A13 - Canis lupus familiaris (Dog) - ANXA13 gene Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup. Indicus|evm.model.CM009504.1.195 Q2WGJ6 KLH38_HUMAN 86.254 0.947627 1.05164 KLHL38 - Kelch-like protein 38 - Homo sapiens (Human) - KLHL38 gene Indicus|evm.model.CM009504.1.196 Q2M2U4 RNH2C_BOVIN 59.483 0.904762 0.763636 RNASEH2C - Ribonuclease H2 subunit C - Bos taurus (Bovine) - RNASEH2C gene Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). Indicus|evm.model.CM009504.1.197 Q2KHT6 FBX32_BOVIN 100.000 0.994382 1.00282 FBXO32 - F-box only protein 32 - Bos taurus (Bovine) - FBXO32 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). Indicus|evm.model.CM009504.1.198 Q3T0D3 NTAQ1_BOVIN 100.000 0.990385 1.00483 NTAQ1 - Protein N-terminal glutamine amidohydrolase - Bos taurus (Bovine) - NTAQ1 gene Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. Indicus|evm.model.CM009504.1.199 Q5RDX4 ATAD2_PONAB 95.146 0.0742358 1.2594 ATAD2 - ATPase family AAA domain-containing protein 2 - Pongo abelii (Sumatran orangutan) - ATAD2 gene May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity). Indicus|evm.model.CM009504.1.200 A2T7S4 ZHX1_PONPY 94.502 0.997712 1.00115 ZHX1 - Zinc fingers and homeoboxes protein 1 - Pongo pygmaeus (Bornean orangutan) - ZHX1 gene Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins (By similarity). Indicus|evm.model.CM009504.1.201 Q96EF9 ZHX1R_HUMAN 84.946 0.725594 1.29795 ZHX1-C8orf76 - Zinc fingers and homeoboxes protein 1, isoform 2 - Homo sapiens (Human) - ZHX1-C8orf76 gene Indicus|evm.model.CM009504.1.202 Q86UY5 FA83A_HUMAN 83.716 0.995413 1.00461 FAM83A - Protein FAM83A - Homo sapiens (Human) - FAM83A gene Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. Indicus|evm.model.CM009504.1.203 Q29RL0 TBC31_BOVIN 99.812 0.99812 1.00094 TBC1D31 - TBC1 domain family member 31 - Bos taurus (Bovine) - TBC1D31 gene centrosome Indicus|evm.model.CM009504.1.204 Q71SS4 DERL1_BOVIN 87.251 0.990909 0.876494 DERL1 - Derlin-1 - Bos taurus (Bovine) - DERL1 gene Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Indicus|evm.model.CM009504.1.205 Q9Y6X8 ZHX2_HUMAN 91.169 0.997616 1.00239 ZHX2 - Zinc fingers and homeoboxes protein 2 - Homo sapiens (Human) - ZHX2 gene Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). Indicus|evm.model.CM009504.1.207 Q17QF2 EFMT1_BOVIN 89.116 0.884848 0.730088 EEF1AKMT1 - EEF1A lysine methyltransferase 1 - Bos taurus (Bovine) - EEF1AKMT1 gene Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'. Indicus|evm.model.CM009504.1.208 O97711 HYAS2_BOVIN 99.585 0.995859 0.875 HAS2 - Hyaluronan synthase 2 - Bos taurus (Bovine) - HAS2 gene Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity). Indicus|evm.model.CM009504.1.210 P46089 GPR3_HUMAN 95.000 0.378641 0.312121 GPR3 - G-protein coupled receptor 3 - Homo sapiens (Human) - GPR3 gene Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity). Indicus|evm.model.CM009504.1.213 Q14159 SPIDR_HUMAN 62.408 0.997875 1.02842 SPIDR - DNA repair-scaffolding protein - Homo sapiens (Human) - SPIDR gene Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. Indicus|evm.model.CM009504.1.214 A5PK61 H3C_BOVIN 100.000 0.985401 1.00735 H3-5 - Histone H3.3C - Bos taurus (Bovine) - H3-5 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009504.1.215 Q8WN22 PRKDC_CANLF 78.710 0.996848 0.995415 PRKDC - DNA-dependent protein kinase catalytic subunit - Canis lupus familiaris (Dog) - PRKDC gene Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (By similarity). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (By similarity). Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (By similarity). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). Indicus|evm.model.CM009504.1.216 P33991 MCM4_HUMAN 90.476 0.22252 0.432213 MCM4 - DNA replication licensing factor MCM4 - Homo sapiens (Human) - MCM4 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Indicus|evm.model.CM009504.1.217 Q5R6C9 UB2V2_PONAB 100.000 0.676056 1.46897 UBE2V2 - Ubiquitin-conjugating enzyme E2 variant 2 - Pongo abelii (Sumatran orangutan) - UBE2V2 gene Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity). Indicus|evm.model.CM009504.1.218 P33991 MCM4_HUMAN 97.917 0.56213 0.195829 MCM4 - DNA replication licensing factor MCM4 - Homo sapiens (Human) - MCM4 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Indicus|evm.model.CM009504.1.220 Q32L26 EFCB1_BOVIN 100.000 0.99061 1.00472 EFCAB1 - EF-hand calcium-binding domain-containing protein 1 - Bos taurus (Bovine) - EFCAB1 gene Indicus|evm.model.CM009504.1.222 Q3MHQ4 SNAI2_BOVIN 100.000 0.992565 1.00373 SNAI2 - Zinc finger protein SNAI2 - Bos taurus (Bovine) - SNAI2 gene Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). Indicus|evm.model.CM009504.1.223 A8E653 PDPFL_BOVIN 97.887 0.986014 1.01418 PPDPFL - Pancreatic progenitor cell differentiation and proliferation factor-like protein - Bos taurus (Bovine) - PPDPFL gene Indicus|evm.model.CM009504.1.224 Q9NSN8 SNTG1_HUMAN 79.518 0.844262 0.943907 SNTG1 - Gamma-1-syntrophin - Homo sapiens (Human) - SNTG1 gene Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation. Indicus|evm.model.CM009504.1.226 Q58CZ2 PCMD2_BOVIN 87.500 0.639752 0.445983 PCMTD2 - Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 - Bos taurus (Bovine) - PCMTD2 gene cytoplasm, protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Indicus|evm.model.CM009504.1.228 A2VDP2 PCMD1_BOVIN 100.000 0.994398 1.00281 PCMTD1 - Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 - Bos taurus (Bovine) - PCMTD1 gene cytoplasm, protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Indicus|evm.model.CM009504.1.230 O60284 ST18_HUMAN 87.179 0.959744 1.04394 ST18 - Suppression of tumorigenicity 18 protein - Homo sapiens (Human) - ST18 gene Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells. Indicus|evm.model.CM009504.1.231 Q3T174 TAF12_BOVIN 96.667 0.823204 1.12422 TAF12 - Transcription initiation factor TFIID subunit 12 - Bos taurus (Bovine) - TAF12 gene TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription (By similarity). Indicus|evm.model.CM009504.1.233 Q8TDY2 RBCC1_HUMAN 88.080 0.998742 0.997491 RB1CC1 - RB1-inducible coiled-coil protein 1 - Homo sapiens (Human) - RB1CC1 gene Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Indicus|evm.model.CM009504.1.235 Q8MJV3 NPBW1_BOVIN 99.396 0.993976 1.00302 NPBWR1 - Neuropeptides B/W receptor type 1 - Bos taurus (Bovine) - NPBWR1 gene Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity). Indicus|evm.model.CM009504.1.236 Q2KIP6 OPRK_BOVIN 100.000 0.994751 1.00263 OPRK1 - Kappa-type opioid receptor - Bos taurus (Bovine) - OPRK1 gene G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions (By similarity). Indicus|evm.model.CM009504.1.237 O46563 VATH_BOVIN 99.586 0.995868 1.00207 ATP6V1H - V-type proton ATPase subunit H - Bos taurus (Bovine) - ATP6V1H gene Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity). Indicus|evm.model.CM009504.1.238 P79348 RGS20_BOVIN 99.020 0.215812 1.25134 RGS20 - Regulator of G-protein signaling 20 - Bos taurus (Bovine) - RGS20 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). Indicus|evm.model.CM009504.1.239 Q3MHR0 LYPA1_BOVIN 99.355 0.345291 1.93913 LYPLA1 - Acyl-protein thioesterase 1 - Bos taurus (Bovine) - LYPLA1 gene Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Has depalmitoylating activity toward KCNMA1 (By similarity). Could also depalmitoylate ADRB2 (By similarity). Acts as a lysophospholipase hydrolyzing various lysophospholipids including lysophosphatidylcholine (lyso-PC), lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (By similarity). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity). Indicus|evm.model.CM009504.1.240 Q0VC21 RM15_BOVIN 99.663 0.993289 1.00337 MRPL15 - 39S ribosomal protein L15, mitochondrial precursor - Bos taurus (Bovine) - MRPL15 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009504.1.242 Q9H6I2 SOX17_HUMAN 91.120 0.627737 0.992754 SOX17 - Transcription factor SOX-17 - Homo sapiens (Human) - SOX17 gene Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells. Indicus|evm.model.CM009504.1.246 Q5GH67 XKR4_MOUSE 100.000 0.470588 0.131376 Xkr4 - XK-related protein 4 - Mus musculus (Mouse) - Xkr4 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Indicus|evm.model.CM009504.1.247 Q5GH76 XKR4_HUMAN 97.792 0.963415 0.504615 XKR4 - XK-related protein 4 - Homo sapiens (Human) - XKR4 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Indicus|evm.model.CM009504.1.248 Q0VCR6 TMM68_BOVIN 100.000 0.99403 1.00299 TMEM68 - Transmembrane protein 68 - Bos taurus (Bovine) - TMEM68 gene Indicus|evm.model.CM009504.1.249 Q96RS0 TGS1_HUMAN 72.442 0.997664 1.00352 TGS1 - Trimethylguanosine synthase - Homo sapiens (Human) - TGS1 gene Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. Indicus|evm.model.CM009504.1.251 P07948 LYN_HUMAN 96.875 0.996101 1.00195 LYN - Tyrosine-protein kinase Lyn - Homo sapiens (Human) - LYN gene Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Indicus|evm.model.CM009504.1.252 P60868 RS20_RAT 100.000 0.983333 1.0084 Rps20 - 40S ribosomal protein S20 - Rattus norvegicus (Rat) - Rps20 gene cytosolic small ribosomal subunit, small ribosomal subunit, synapse, structural constituent of ribosome Indicus|evm.model.CM009504.1.253 P50118 MOS_PIG 75.793 0.973607 0.988406 MOS - Proto-oncogene serine/threonine-protein kinase mos - Sus scrofa (Pig) - MOS gene cytoplasm, cytosol, MAP kinase kinase kinase activity, protein kinase activity, protein serine/threonine kinase activity, activation of MAPK activity, activation of MAPKK activity, chromatin organization, ERK1 and ERK2 cascade, establishment of meiotic spindle orientation Indicus|evm.model.CM009504.1.254 Q6DJT9 PLAG1_HUMAN 96.400 0.996 1 PLAG1 - Zinc finger protein PLAG1 - Homo sapiens (Human) - PLAG1 gene Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. Indicus|evm.model.CM009504.1.257 Q17Q91 CHCH7_BOVIN 100.000 0.205128 1.37647 CHCHD7 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 - Bos taurus (Bovine) - CHCHD7 gene Indicus|evm.model.CM009504.1.258 Q8N3Y7 RDHE2_HUMAN 78.571 0.814324 1.22006 SDR16C5 - Epidermal retinol dehydrogenase 2 - Homo sapiens (Human) - SDR16C5 gene Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. Indicus|evm.model.CM009504.1.259 A5PJJ7 S16C6_BOVIN 98.765 0.991803 0.772152 SDR16C6 - Short-chain dehydrogenase/reductase family 16C member 6 - Bos taurus (Bovine) - SDR16C6 gene lipid droplet, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Indicus|evm.model.CM009504.1.260 P01211 PENK_BOVIN 99.620 0.992424 1.0038 PENK - Proenkephalin-A precursor - Bos taurus (Bovine) - PENK gene Enkelytin possesses antibacterial activity against Gram-positive bacteria such as Micrococcus luteus and Bacillus megaterium. Indicus|evm.model.CM009504.1.261 Q2KJ53 IMPA3_BOVIN 98.895 0.994444 0.994475 BPNT2 - Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase - Bos taurus (Bovine) - BPNT2 gene Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4. Indicus|evm.model.CM009504.1.262 Q2KJ38 F110B_BOVIN 100.000 0.419355 1.06053 FAM110B - Protein FAM110B - Bos taurus (Bovine) - FAM110B gene Indicus|evm.model.CM009504.1.264 Q14CS0 UBX2B_HUMAN 90.030 0.993976 1.00302 UBXN2B - UBX domain-containing protein 2B - Homo sapiens (Human) - UBXN2B gene Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). Indicus|evm.model.CM009504.1.265 O46491 CP7A1_PIG 88.600 0.994012 1 CYP7A1 - Cytochrome P450 7A1 - Sus scrofa (Pig) - CYP7A1 gene A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis. 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives. Indicus|evm.model.CM009504.1.266 O00560 SDCB1_HUMAN 92.953 0.86087 1.15772 SDCBP - Syntenin-1 - Homo sapiens (Human) - SDCBP gene Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). Indicus|evm.model.CM009504.1.267 Q92636 FAN_HUMAN 89.357 0.986857 0.995638 NSMAF - Protein FAN - Homo sapiens (Human) - NSMAF gene Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE. Indicus|evm.model.CM009504.1.268 O94900 TOX_HUMAN 95.446 0.996212 1.0038 TOX - Thymocyte selection-associated high mobility group box protein TOX - Homo sapiens (Human) - TOX gene Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:21126536) (By similarity). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (By similarity). Indicus|evm.model.CM009504.1.269 P35219 CAH8_HUMAN 80.690 0.991597 0.82069 CA8 - Carbonic anhydrase-related protein - Homo sapiens (Human) - CA8 gene Does not have a carbonic anhydrase catalytic activity. Indicus|evm.model.CM009504.1.270 Q5R8Z3 EF2_PONAB 64.734 0.264793 0.787879 EEF2 - Elongation factor 2 - Pongo abelii (Sumatran orangutan) - EEF2 gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Indicus|evm.model.CM009504.1.271 Q5R6B6 RAB2A_PONAB 87.374 0.901554 0.910377 RAB2A - Ras-related protein Rab-2A - Pongo abelii (Sumatran orangutan) - RAB2A gene Required for protein transport from the endoplasmic reticulum to the Golgi complex. Indicus|evm.model.CM009504.1.273 Q9P2D1 CHD7_HUMAN 95.413 0.0369357 0.975642 CHD7 - Chromodomain-helicase-DNA-binding protein 7 - Homo sapiens (Human) - CHD7 gene Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. Indicus|evm.model.CM009504.1.274 Q8IUQ0 CLVS1_HUMAN 100.000 0.984733 0.370056 CLVS1 - Clavesin-1 - Homo sapiens (Human) - CLVS1 gene Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Indicus|evm.model.CM009504.1.275 Q28056 ASPH_BOVIN 98.044 0.997396 1.01857 ASPH - Aspartyl/asparaginyl beta-hydroxylase - Bos taurus (Bovine) - ASPH gene Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. Indicus|evm.model.CM009504.1.276 Q3URJ8 NKAI3_MOUSE 96.894 0.615385 1.43646 Nkain3 - Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 - Mus musculus (Mouse) - Nkain3 gene membrane, regulation of sodium ion transport Indicus|evm.model.CM009504.1.277 A8D8X1 RL10_SHEEP 62.500 0.660714 0.261682 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009504.1.278 A7YWG4 GGH_BOVIN 100.000 0.99373 1.00314 GGH - Gamma-glutamyl hydrolase precursor - Bos taurus (Bovine) - GGH gene Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Exhibits either endo- or exopeptidase activity depending upon the tissue of origin. When secreted, it acts primarily as an endopeptidase (By similarity). Indicus|evm.model.CM009504.1.279 P49638 TTPA_HUMAN 88.129 0.975265 1.01799 TTPA - Alpha-tocopherol transfer protein - Homo sapiens (Human) - TTPA gene Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity). Indicus|evm.model.CM009504.1.280 Q5RFL8 YTHD3_PONAB 98.276 0.917591 1.07863 YTHDF3 - YTH domain-containing family protein 3 - Pongo abelii (Sumatran orangutan) - YTHDF3 gene Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (By similarity). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs. Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation. Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation. The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules. May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (By similarity). Indicus|evm.model.CM009504.1.284 Q8NFJ8 BHE22_HUMAN 100.000 0.788136 0.309711 BHLHE22 - Class E basic helix-loop-helix protein 22 - Homo sapiens (Human) - BHLHE22 gene Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. Indicus|evm.model.CM009504.1.286 O75881 CP7B1_HUMAN 71.915 0.930417 0.994071 CYP7B1 - Cytochrome P450 7B1 - Homo sapiens (Human) - CYP7B1 gene A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids (PubMed:10588945, PubMed:24491228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10588945, PubMed:24491228). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position (PubMed:10588945, PubMed:24491228). Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy steroid 7-alpha hydroxylase (PubMed:24491228). Hydroxylates oxysterols, including 25-hydroxycholesterol and (25R)-cholest-5-ene-3beta,26-diol toward 7-alpha hydroxy derivatives, which may be transported to the liver and converted to bile acids (PubMed:9802883, PubMed:10588945). Via its product 7-alpha,25-dihydroxycholesterol, a ligand for the chemotactic G protein-coupled receptor GPR183/EBI2, regulates B cell migration in germinal centers of lymphoid organs, thus guiding efficient maturation of plasma B cells and overall antigen-specific humoral immune response (By similarity). 7-alpha hydroxylates neurosteroids, including 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone) and pregnenolone, both involved in hippocampus-associated memory and learning (PubMed:24491228). Metabolizes androstanoids toward 6- or 7-alpha hydroxy derivatives (PubMed:24491228). Indicus|evm.model.CM009504.1.287 Q3ZBE1 ARMC1_BOVIN 100.000 0.992933 1.00355 ARMC1 - Armadillo repeat-containing protein 1 - Bos taurus (Bovine) - ARMC1 gene In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. Indicus|evm.model.CM009504.1.288 Q15390 MTFR1_HUMAN 78.154 0.96131 1.00901 MTFR1 - Mitochondrial fission regulator 1 precursor - Homo sapiens (Human) - MTFR1 gene May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). Indicus|evm.model.CM009504.1.289 Q13946 PDE7A_HUMAN 96.575 0.954148 0.950207 PDE7A - High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A - Homo sapiens (Human) - PDE7A gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. Indicus|evm.model.CM009504.1.290 Q2KIJ8 DNJ5B_BOVIN 100.000 0.99 1.00503 DNAJC5B - DnaJ homolog subfamily C member 5B - Bos taurus (Bovine) - DNAJC5B gene Indicus|evm.model.CM009504.1.291 Q9BYV6 TRI55_HUMAN 86.182 0.996337 0.99635 TRIM55 - Tripartite motif-containing protein 55 - Homo sapiens (Human) - TRIM55 gene May regulate gene expression and protein turnover in muscle cells. Indicus|evm.model.CM009504.1.292 Q95MI6 CRF_BOVIN 100.000 0.989529 1.00526 CRH - Corticoliberin precursor - Bos taurus (Bovine) - CRH gene Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). Indicus|evm.model.CM009504.1.294 P25976 UBF1_MOUSE 62.037 0.690789 0.198693 Ubtf - Nucleolar transcription factor 1 - Mus musculus (Mouse) - Ubtf gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Indicus|evm.model.CM009504.1.296 Q2KIH4 RRS1_BOVIN 98.904 0.994536 1.00274 RRS1 - Ribosome biogenesis regulatory protein homolog - Bos taurus (Bovine) - RRS1 gene Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. Indicus|evm.model.CM009504.1.297 A6QP15 HOT_BOVIN 100.000 0.995717 1.00215 ADHFE1 - Hydroxyacid-oxoacid transhydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ADHFE1 gene Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity). Indicus|evm.model.CM009504.1.298 Q0VCV7 VEXIN_BOVIN 100.000 0.990196 1.00493 VXN - Vexin - Bos taurus (Bovine) - VXN gene Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis. Indicus|evm.model.CM009504.1.299 P10243 MYBA_HUMAN 92.824 0.995434 0.87367 MYBL1 - Myb-related protein A - Homo sapiens (Human) - MYBL1 gene Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity). Indicus|evm.model.CM009504.1.300 Q96JH7 VCIP1_HUMAN 93.464 0.998326 0.977905 VCPIP1 - Deubiquitinating protein VCPIP1 - Homo sapiens (Human) - VCPIP1 gene Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). Indicus|evm.model.CM009504.1.301 Q5R7A7 SGK3_PONAB 97.959 0.995927 0.989919 SGK3 - Serine/threonine-protein kinase Sgk3 - Pongo abelii (Sumatran orangutan) - SGK3 gene Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes (By similarity). Indicus|evm.model.CM009504.1.302 Q4G0Z9 MCMD2_HUMAN 90.896 0.997067 1.00147 MCMDC2 - Minichromosome maintenance domain-containing protein 2 - Homo sapiens (Human) - MCMDC2 gene Plays an important role in meiotic recombination and associated DNA double-strand break repair. Indicus|evm.model.CM009504.1.303 Q7RTU0 TCF24_HUMAN 89.231 0.565789 1.36527 TCF24 - Transcription factor 24 - Homo sapiens (Human) - TCF24 gene Putative transcription factor. Indicus|evm.model.CM009504.1.304 Q4R803 PPR42_MACFA 92.075 0.970588 0.761905 PPP1R42 - Protein phosphatase 1 regulatory subunit 42 - Macaca fascicularis (Crab-eating macaque) - PPP1R42 gene Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis. Indicus|evm.model.CM009504.1.305 Q92905 CSN5_HUMAN 99.701 0.99403 1.00299 COPS5 - COP9 signalosome complex subunit 5 - Homo sapiens (Human) - COPS5 gene Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. Indicus|evm.model.CM009504.1.306 Q1MSJ5 CSPP1_HUMAN 85.137 0.944785 1.03822 CSPP1 - Centrosome and spindle pole-associated protein 1 - Homo sapiens (Human) - CSPP1 gene May play a role in cell-cycle-dependent microtubule organization. Indicus|evm.model.CM009504.1.307 O46382 BIG1_BOVIN 99.892 0.998919 1.00054 ARFGEF1 - Brefeldin A-inhibited guanine nucleotide-exchange protein 1 - Bos taurus (Bovine) - ARFGEF1 gene Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined (By similarity). Indicus|evm.model.CM009504.1.308 Q8N4T0 CBPA6_HUMAN 89.724 0.923434 0.98627 CPA6 - Carboxypeptidase A6 precursor - Homo sapiens (Human) - CPA6 gene May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II (PubMed:18178555). Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine (PubMed:20855895). Indicus|evm.model.CM009504.1.310 Q49A92 CH034_HUMAN 91.221 0.992395 0.488848 C8orf34 - Uncharacterized protein C8orf34 - Homo sapiens (Human) - C8orf34 gene Indicus|evm.model.CM009504.1.311 Q49A92 CH034_HUMAN 76.364 0.5625 0.178439 C8orf34 - Uncharacterized protein C8orf34 - Homo sapiens (Human) - C8orf34 gene Indicus|evm.model.CM009504.1.312 Q8IWU6 SULF1_HUMAN 87.931 0.0579858 1.12859 SULF1 - Extracellular sulfatase Sulf-1 precursor - Homo sapiens (Human) - SULF1 gene Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. Indicus|evm.model.CM009504.1.313 Q9H2Y9 SO5A1_HUMAN 87.779 0.997639 0.998821 SLCO5A1 - Solute carrier organic anion transporter family member 5A1 - Homo sapiens (Human) - SLCO5A1 gene integral component of plasma membrane, intracellular membrane-bounded organelle, plasma membrane, sodium-independent organic anion transmembrane transporter activity, sodium-independent organic anion transport Indicus|evm.model.CM009504.1.315 Q9GZV8 PRD14_HUMAN 79.232 0.994755 1.00175 PRDM14 - PR domain zinc finger protein 14 - Homo sapiens (Human) - PRDM14 gene Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. Indicus|evm.model.CM009504.1.316 Q15596 NCOA2_HUMAN 94.130 0.998636 1.00137 NCOA2 - Nuclear receptor coactivator 2 - Homo sapiens (Human) - NCOA2 gene Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Indicus|evm.model.CM009504.1.317 Q9GKZ4 TRAM1_BOVIN 99.401 0.954155 0.933155 TRAM1 - Translocating chain-associated membrane protein 1 - Bos taurus (Bovine) - TRAM1 gene Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel. Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER. May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport. Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane. Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane. Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome. Indicus|evm.model.CM009504.1.318 Q1LZ83 LACB2_BOVIN 99.653 0.99308 1.00347 LACTB2 - Endoribonuclease LACTB2 - Bos taurus (Bovine) - LACTB2 gene Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. Indicus|evm.model.CM009504.1.319 Q49LR9 XKR9_PANTR 83.511 0.780172 0.621984 XKR9 - XK-related protein 9 - Pan troglodytes (Chimpanzee) - XKR9 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Indicus|evm.model.CM009504.1.320 Q99502 EYA1_HUMAN 97.703 0.949324 1 EYA1 - Eyes absent homolog 1 - Homo sapiens (Human) - EYA1 gene Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity). Indicus|evm.model.CM009504.1.321 O60682 MUSC_HUMAN 90.291 0.989899 0.961165 MSC - Musculin - Homo sapiens (Human) - MSC gene Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation. Indicus|evm.model.CM009504.1.322 O75762 TRPA1_HUMAN 80.553 0.996429 1.00089 TRPA1 - Transient receptor potential cation channel subfamily A member 1 - Homo sapiens (Human) - TRPA1 gene Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:25855297). Shows 8-fold preference for divalent over monovalent cations (PubMed:31447178). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:27241698, PubMed:30878828, PubMed:20547126). Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). Is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). Indicus|evm.model.CM009504.1.323 Q4ZHA6 KCNB2_BOVIN 99.485 0.989744 0.21405 KCNB2 - Potassium voltage-gated channel subfamily B member 2 - Bos taurus (Bovine) - KCNB2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Indicus|evm.model.CM009504.1.324 Q4ZHA6 KCNB2_BOVIN 99.444 0.991724 0.795829 KCNB2 - Potassium voltage-gated channel subfamily B member 2 - Bos taurus (Bovine) - KCNB2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Indicus|evm.model.CM009504.1.325 P54274 TERF1_HUMAN 82.955 0.995423 0.995444 TERF1 - Telomeric repeat-binding factor 1 - Homo sapiens (Human) - TERF1 gene Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Indicus|evm.model.CM009504.1.326 Q32L50 SBSPO_BOVIN 98.883 0.706349 0.954545 SBSPON - Somatomedin-B and thrombospondin type-1 domain-containing protein precursor - Bos taurus (Bovine) - SBSPON gene Indicus|evm.model.CM009504.1.327 Q58DT1 RL7_BOVIN 99.444 0.431325 1.67339 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Indicus|evm.model.CM009504.1.328 Q8IZV5 RDH10_HUMAN 90.323 0.993528 0.906158 RDH10 - Retinol dehydrogenase 10 - Homo sapiens (Human) - RDH10 gene Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol. Indicus|evm.model.CM009504.1.329 Q9NUL3 STAU2_HUMAN 97.050 0.89418 0.663158 STAU2 - Double-stranded RNA-binding protein Staufen homolog 2 - Homo sapiens (Human) - STAU2 gene RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). Indicus|evm.model.CM009504.1.330 Q9NUL3 STAU2_HUMAN 96.809 0.885714 0.184211 STAU2 - Double-stranded RNA-binding protein Staufen homolog 2 - Homo sapiens (Human) - STAU2 gene RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). Indicus|evm.model.CM009504.1.331 B5DEI4 UBE2W_RAT 100.000 0.984615 0.860927 Ube2w - Ubiquitin-conjugating enzyme E2 W - Rattus norvegicus (Rat) - Ube2w gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate. Indicus|evm.model.CM009504.1.332 P83941 ELOC_RAT 100.000 0.88 1.11607 Eloc - Elongin-C - Rattus norvegicus (Rat) - Eloc gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). Indicus|evm.model.CM009504.1.335 P58754 LY96_BOVIN 70.000 0.987578 1.00625 LY96 - Lymphocyte antigen 96 precursor - Bos taurus (Bovine) - LY96 gene Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (By similarity). Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. Indicus|evm.model.CM009504.1.336 A4FV48 FADS2_BOVIN 88.070 0.858006 0.745495 FADS2 - Acyl-CoA 6-desaturase - Bos taurus (Bovine) - FADS2 gene Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate, a metabolite in the biohydrogenation pathway of LA and the predominant trans fatty acid in cow milk) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity). Indicus|evm.model.CM009504.1.337 P83917 CBX1_MOUSE 86.792 0.777778 0.72973 Cbx1 - Chromobox protein homolog 1 - Mus musculus (Mouse) - Cbx1 gene Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Indicus|evm.model.CM009504.1.338 Q9HDC5 JPH1_HUMAN 91.982 0.996965 0.996974 JPH1 - Junctophilin-1 - Homo sapiens (Human) - JPH1 gene Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. Indicus|evm.model.CM009504.1.339 A6QQZ0 GDAP1_BOVIN 100.000 0.994429 1.00279 GDAP1 - Ganglioside-induced differentiation-associated protein 1 - Bos taurus (Bovine) - GDAP1 gene Regulates the mitochondrial network by promoting mitochondrial fission. Indicus|evm.model.CM009504.1.340 O43692 PI15_HUMAN 97.674 0.992278 1.00388 PI15 - Peptidase inhibitor 15 precursor - Homo sapiens (Human) - PI15 gene Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity). Indicus|evm.model.CM009504.1.341 Q9H336 CRLD1_HUMAN 89.200 0.995807 0.954 CRISPLD1 - Cysteine-rich secretory protein LCCL domain-containing 1 precursor - Homo sapiens (Human) - CRISPLD1 gene extracellular exosome, extracellular space, face morphogenesis Indicus|evm.model.CM009504.1.343 Q14541 HNF4G_HUMAN 96.814 0.87905 1.1348 HNF4G - Hepatocyte nuclear factor 4-gamma - Homo sapiens (Human) - HNF4G gene Transcription factor. Has a lower transcription activation potential than HNF4-alpha. Indicus|evm.model.CM009504.1.345 Q9NR30 DDX21_HUMAN 87.222 0.957219 0.238825 DDX21 - Nucleolar RNA helicase 2 - Homo sapiens (Human) - DDX21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Indicus|evm.model.CM009504.1.346 Q86UP3 ZFHX4_HUMAN 93.901 0.978199 0.295767 ZFHX4 - Zinc finger homeobox protein 4 - Homo sapiens (Human) - ZFHX4 gene May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. Indicus|evm.model.CM009504.1.347 Q86UP3 ZFHX4_HUMAN 94.872 0.681416 0.0316793 ZFHX4 - Zinc finger homeobox protein 4 - Homo sapiens (Human) - ZFHX4 gene May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. Indicus|evm.model.CM009504.1.348 Q86UP3 ZFHX4_HUMAN 93.697 0.609921 0.706476 ZFHX4 - Zinc finger homeobox protein 4 - Homo sapiens (Human) - ZFHX4 gene May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. Indicus|evm.model.CM009504.1.350 P28328 PEX2_HUMAN 87.171 0.990196 1.00328 PEX2 - Peroxisome biogenesis factor 2 - Homo sapiens (Human) - PEX2 gene Somewhat implicated in the biogenesis of peroxisomes. Indicus|evm.model.CM009504.1.351 Q96LD8 SENP8_HUMAN 90.521 0.985915 1.00472 SENP8 - Sentrin-specific protease 8 - Homo sapiens (Human) - SENP8 gene Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. Indicus|evm.model.CM009504.1.352 Q5E943 CA043_BOVIN 86.869 0.98 0.395257 Protein C1orf43 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009504.1.353 Q5E943 CA043_BOVIN 91.667 0.986207 0.573123 Protein C1orf43 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009504.1.354 P46193 ANXA1_BOVIN 94.509 0.9941 0.979769 ANXA1 - Annexin A1 - Bos taurus (Bovine) - ANXA1 gene Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). Indicus|evm.model.CM009504.1.355 Q8CAY6 THIC_MOUSE 79.487 0.673913 0.579345 Acat2 - Acetyl-CoA acetyltransferase, cytosolic - Mus musculus (Mouse) - Acat2 gene Involved in the biosynthetic pathway of cholesterol. Indicus|evm.model.CM009504.1.356 Q3SX13 IPKA_BOVIN 100.000 0.974026 1.01316 PKIA - cAMP-dependent protein kinase inhibitor alpha - Bos taurus (Bovine) - PKIA gene Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Indicus|evm.model.CM009504.1.357 A4FUE7 ZC21A_BOVIN 99.628 0.985294 0.842105 ZC2HC1A - Zinc finger C2HC domain-containing protein 1A - Bos taurus (Bovine) - ZC2HC1A gene Indicus|evm.model.CM009504.1.358 P26895 IL7_BOVIN 99.254 0.93662 0.806818 IL7 - Interleukin-7 precursor - Bos taurus (Bovine) - IL7 gene Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Indicus|evm.model.CM009504.1.359 P55821 STMN2_MOUSE 100.000 0.988166 0.944134 Stmn2 - Stathmin-2 - Mus musculus (Mouse) - Stmn2 gene Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. Indicus|evm.model.CM009504.1.360 Q2KIN4 HEY1_BOVIN 100.000 0.993443 1.00329 HEY1 - Hairy/enhancer-of-split related with YRPW motif protein 1 - Bos taurus (Bovine) - HEY1 gene Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. Indicus|evm.model.CM009504.1.361 P14851 PPIA_CRIGR 58.000 0.462264 0.646341 PPIA - Peptidyl-prolyl cis-trans isomerase A - Cricetulus griseus (Chinese hamster) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009504.1.362 P82928 RT28_BOVIN 96.350 0.894737 0.804233 MRPS28 - 28S ribosomal protein S28, mitochondrial precursor - Bos taurus (Bovine) - MRPS28 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrial translation Indicus|evm.model.CM009504.1.363 P55327 TPD52_HUMAN 84.211 0.932735 0.995536 TPD52 - Tumor protein D52 - Homo sapiens (Human) - TPD52 gene cytoplasm, endoplasmic reticulum, perinuclear region of cytoplasm, calcium ion binding, protein homodimerization activity, anatomical structure morphogenesis, B cell differentiation, secretion Indicus|evm.model.CM009504.1.364 Q96DT7 ZBT10_HUMAN 93.620 0.949766 0.982778 ZBTB10 - Zinc finger and BTB domain-containing protein 10 - Homo sapiens (Human) - ZBTB10 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009504.1.365 Q9TRY0 FKBP4_BOVIN 50.388 0.941379 0.631808 FKBP4 - Peptidyl-prolyl cis-trans isomerase FKBP4 - Bos taurus (Bovine) - FKBP4 gene Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening (By similarity). Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria (By similarity). Indicus|evm.model.CM009504.1.366 Q6ZNC4 ZN704_HUMAN 96.114 0.994832 0.93932 ZNF704 - Zinc finger protein 704 - Homo sapiens (Human) - ZNF704 gene Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. Indicus|evm.model.CM009504.1.367 Q9NWQ8 PHAG1_HUMAN 82.028 0.995402 1.00694 PAG1 - Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 - Homo sapiens (Human) - PAG1 gene Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. Indicus|evm.model.CM009504.1.368 P55052 FABP5_BOVIN 96.296 0.128713 1.4963 FABP5 - Fatty acid-binding protein 5 - Bos taurus (Bovine) - FABP5 gene Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). Indicus|evm.model.CM009504.1.369 P02690 MYP2_BOVIN 100.000 0.757009 0.810606 PMP2 - Myelin P2 protein - Bos taurus (Bovine) - PMP2 gene May play a role in lipid transport protein in Schwann cells. May bind cholesterol. Indicus|evm.model.CM009504.1.370 Q0Z7S8 FABP9_HUMAN 71.970 0.984962 1.00758 FABP9 - Fatty acid-binding protein 9 - Homo sapiens (Human) - FABP9 gene cytosol, triglyceride catabolic process Indicus|evm.model.CM009504.1.371 P48035 FABP4_BOVIN 98.485 0.984962 1.00758 FABP4 - Fatty acid-binding protein, adipocyte - Bos taurus (Bovine) - FABP4 gene Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Indicus|evm.model.CM009504.1.372 Q9DAK4 FBP12_MOUSE 84.091 0.929078 1.06818 Fabp12 - Fatty acid-binding protein 12 - Mus musculus (Mouse) - Fabp12 gene May play a role in lipid transport. Indicus|evm.model.CM009504.1.373 P48745 CCN3_HUMAN 80.636 0.969101 0.997199 CCN3 - CCN family member 3 precursor - Homo sapiens (Human) - CCN3 gene Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891). Indicus|evm.model.CM009504.1.374 A2VE13 MAL2_BOVIN 100.000 0.988701 1.00568 MAL2 - Protein MAL2 - Bos taurus (Bovine) - MAL2 gene Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (By similarity). Indicus|evm.model.CM009504.1.375 Q9Y6Z7 COL10_HUMAN 85.199 0.992126 0.916968 COLEC10 - Collectin-10 precursor - Homo sapiens (Human) - COLEC10 gene Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (PubMed:10224141). Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481). Indicus|evm.model.CM009504.1.376 A5D7R1 TR11B_BOVIN 100.000 0.995037 1.00249 TNFRSF11B - Tumor necrosis factor receptor superfamily member 11B precursor - Bos taurus (Bovine) - TNFRSF11B gene Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity). Indicus|evm.model.CM009504.1.377 Q5RDW3 SAM12_PONAB 95.946 0.907407 0.80597 SAMD12 - Sterile alpha motif domain-containing protein 12 - Pongo abelii (Sumatran orangutan) - SAMD12 gene Indicus|evm.model.CM009504.1.378 A5D7I4 EXT1_BOVIN 100.000 0.997323 1.00134 EXT1 - Exostosin-1 - Bos taurus (Bovine) - EXT1 gene Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Indicus|evm.model.CM009504.1.380 Q2YDF2 MED30_BOVIN 100.000 0.814607 0.92228 MED30 - Mediator of RNA polymerase II transcription subunit 30 - Bos taurus (Bovine) - MED30 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009504.1.381 Q8IWU4 ZNT8_HUMAN 89.583 0.489583 0.260163 SLC30A8 - Zinc transporter 8 - Homo sapiens (Human) - SLC30A8 gene Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. Indicus|evm.model.CM009504.1.382 Q8IWU4 ZNT8_HUMAN 75.172 0.953642 0.409214 SLC30A8 - Zinc transporter 8 - Homo sapiens (Human) - SLC30A8 gene Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. Indicus|evm.model.CM009504.1.383 Q4LEZ3 AARD_HUMAN 55.128 0.987013 0.993548 AARD - Alanine and arginine-rich domain-containing protein - Homo sapiens (Human) - AARD gene Indicus|evm.model.CM009504.1.384 Q3SWX9 RAD21_BOVIN 100.000 0.99683 1.00159 RAD21 - Double-strand-break repair protein rad21 homolog - Bos taurus (Bovine) - RAD21 gene As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression. Binds to and represses APOB gene promoter (By similarity). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). Indicus|evm.model.CM009504.1.385 Q08DU1 UTP23_BOVIN 100.000 0.991968 1.00403 UTP23 - rRNA-processing protein UTP23 homolog - Bos taurus (Bovine) - UTP23 gene Involved in rRNA-processing and ribosome biogenesis. Indicus|evm.model.CM009504.1.386 Q56JZ5 EIF3H_BOVIN 99.716 0.994334 1.00284 EIF3H - Eukaryotic translation initiation factor 3 subunit H - Bos taurus (Bovine) - EIF3H gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Indicus|evm.model.CM009504.1.387 E1BHC3 PT100_BOVIN 88.158 0.852273 1.15789 PET100 - Protein PET100 homolog, mitochondrial precursor - Bos taurus (Bovine) - PET100 gene Plays a role in mitochondrial complex IV assembly. Indicus|evm.model.CM009504.1.388 Q8MTV8 H4_APLCA 94.118 0.857143 0.951456 His.H4 - Histone H4 - Aplysia californica (California sea hare) - His.H4 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009504.1.390 Q9UHF7 TRPS1_HUMAN 91.776 0.92952 0.764247 TRPS1 - Zinc finger transcription factor Trps1 - Homo sapiens (Human) - TRPS1 gene Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Indicus|evm.model.CM009504.1.391 Q9UHF7 TRPS1_HUMAN 97.744 0.992519 0.313037 TRPS1 - Zinc finger transcription factor Trps1 - Homo sapiens (Human) - TRPS1 gene Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Indicus|evm.model.CM009504.1.400 Q7Z407 CSMD3_HUMAN 100.000 0.982143 0.0151066 CSMD3 - CUB and sushi domain-containing protein 3 - Homo sapiens (Human) - CSMD3 gene Involved in dendrite development. Indicus|evm.model.CM009504.1.407 Q7Z407 CSMD3_HUMAN 79.328 0.99023 0.469382 CSMD3 - CUB and sushi domain-containing protein 3 - Homo sapiens (Human) - CSMD3 gene Involved in dendrite development. Indicus|evm.model.CM009504.1.408 Q9NY97 B3GN2_HUMAN 88.947 0.926471 0.513854 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Homo sapiens (Human) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. Indicus|evm.model.CM009504.1.409 Q0P583 KCNV1_BOVIN 100.000 0.992048 1 KCNV1 - Potassium voltage-gated channel subfamily V member 1 - Bos taurus (Bovine) - KCNV1 gene Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity). Indicus|evm.model.CM009504.1.411 Q9NX95 SYBU_HUMAN 80.838 0.926864 1.0724 SYBU - Syntabulin - Homo sapiens (Human) - SYBU gene Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. Indicus|evm.model.CM009504.1.412 Q865S0 RCAS1_CANLF 99.061 0.990654 1.00469 EBAG9 - Receptor-binding cancer antigen expressed on SiSo cells - Canis lupus familiaris (Dog) - EBAG9 gene May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. Indicus|evm.model.CM009504.1.413 Q86WI1 PKHL1_HUMAN 82.876 0.999286 0.990808 PKHD1L1 - Fibrocystin-L precursor - Homo sapiens (Human) - PKHD1L1 gene cytosol, extracellular space, integral component of membrane, signaling receptor activity, immune response Indicus|evm.model.CM009504.1.414 Q9JIX0 ENY2_MOUSE 100.000 0.980392 1.0099 Eny2 - Transcription and mRNA export factor ENY2 - Mus musculus (Mouse) - Eny2 gene Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Indicus|evm.model.CM009504.1.415 Q96RS6 NUDC1_HUMAN 96.000 0.175844 0.965695 NUDCD1 - NudC domain-containing protein 1 - Homo sapiens (Human) - NUDCD1 gene cytosol, nucleoplasm Indicus|evm.model.CM009504.1.416 O46639 TRFR_BOVIN 100.000 0.994987 1.00251 TRHR - Thyrotropin-releasing hormone receptor - Bos taurus (Bovine) - TRHR gene Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. Indicus|evm.model.CM009504.1.419 Q96NL1 TMM74_HUMAN 86.230 0.993464 1.00328 TMEM74 - Transmembrane protein 74 - Homo sapiens (Human) - TMEM74 gene Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction. Indicus|evm.model.CM009504.1.420 Q5E993 EMC2_BOVIN 100.000 0.89697 1.11111 EMC2 - ER membrane protein complex subunit 2 - Bos taurus (Bovine) - EMC2 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Indicus|evm.model.CM009504.1.421 P24049 RL17_RAT 81.319 0.841121 0.581522 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009504.1.422 Q3T102 EIF3E_BOVIN 100.000 0.995516 1.00225 EIF3E - Eukaryotic translation initiation factor 3 subunit E - Bos taurus (Bovine) - EIF3E gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. Indicus|evm.model.CM009504.1.423 Q8BFU0 RSPO2_MOUSE 75.355 0.987805 0.674897 Rspo2 - R-spondin-2 precursor - Mus musculus (Mouse) - Rspo2 gene Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (PubMed:21693646). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (By similarity). Indicus|evm.model.CM009504.1.424 Q0VCN3 IFT27_BOVIN 98.387 0.989305 1.00538 IFT27 - Intraflagellar transport protein 27 homolog - Bos taurus (Bovine) - IFT27 gene Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation. Indicus|evm.model.CM009504.1.425 Q9Y295 DRG1_HUMAN 98.093 0.994565 1.00272 DRG1 - Developmentally-regulated GTP-binding protein 1 - Homo sapiens (Human) - DRG1 gene Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). Indicus|evm.model.CM009504.1.426 Q9BDY8 ANGP1_PIG 100.000 0.867257 0.226908 ANGPT1 - Angiopoietin-1 precursor - Sus scrofa (Pig) - ANGPT1 gene Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity). Indicus|evm.model.CM009504.1.427 O18920 ANGP1_BOVIN 100.000 0.91791 0.539235 ANGPT1 - Angiopoietin-1 precursor - Bos taurus (Bovine) - ANGPT1 gene Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity). Indicus|evm.model.CM009504.1.428 O35460 ANGP1_RAT 100.000 0.725191 0.263581 Angpt1 - Angiopoietin-1 precursor - Rattus norvegicus (Rat) - Angpt1 gene Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Indicus|evm.model.CM009504.1.429 O97790 TBCD1_BOVIN 79.646 0.449153 0.202575 TBC1D1 - TBC1 domain family member 1 - Bos taurus (Bovine) - TBC1D1 gene May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). Indicus|evm.model.CM009504.1.430 B5SNZ6 ABRA_PIG 83.636 0.994778 0.997396 ABRA - Actin-binding Rho-activating protein - Sus scrofa (Pig) - ABRA gene Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. Indicus|evm.model.CM009504.1.431 A5PKL1 OXR1_BOVIN 96.368 0.888756 0.958716 OXR1 - Oxidation resistance protein 1 - Bos taurus (Bovine) - OXR1 gene May be involved in protection from oxidative damage. Indicus|evm.model.CM009504.1.432 A5PKL1 OXR1_BOVIN 94.286 0.676471 0.116972 OXR1 - Oxidation resistance protein 1 - Bos taurus (Bovine) - OXR1 gene May be involved in protection from oxidative damage. Indicus|evm.model.CM009504.1.434 Q8WW38 FOG2_HUMAN 95.388 0.998039 0.886186 ZFPM2 - Zinc finger protein ZFPM2 - Homo sapiens (Human) - ZFPM2 gene Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). Indicus|evm.model.CM009504.1.436 Q5R662 LRP12_PONAB 96.274 0.997599 0.969732 LRP12 - Low-density lipoprotein receptor-related protein 12 precursor - Pongo abelii (Sumatran orangutan) - LRP12 gene Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor (By similarity). Indicus|evm.model.CM009504.1.437 Q14117 DPYS_HUMAN 86.111 0.281843 0.710983 DPYS - Dihydropyrimidinase - Homo sapiens (Human) - DPYS gene Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Indicus|evm.model.CM009504.1.438 Q9H295 DCSTP_HUMAN 78.678 0.915851 1.08723 DCSTAMP - Dendritic cell-specific transmembrane protein - Homo sapiens (Human) - DCSTAMP gene Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions. Indicus|evm.model.CM009504.1.439 Q9JIS1 RIMS2_RAT 100.000 0.181187 0.834084 Rims2 - Regulating synaptic membrane exocytosis protein 2 - Rattus norvegicus (Rat) - Rims2 gene Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity). Indicus|evm.model.CM009504.1.440 Q9JIS1 RIMS2_RAT 93.220 0.666667 0.0559486 Rims2 - Regulating synaptic membrane exocytosis protein 2 - Rattus norvegicus (Rat) - Rims2 gene Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity). Indicus|evm.model.CM009504.1.442 Q9H2D1 MFTC_HUMAN 80.255 0.853521 1.12698 SLC25A32 - Mitochondrial folate transporter/carrier - Homo sapiens (Human) - SLC25A32 gene Transports folate across the inner membranes of mitochondria (PubMed:15140890, PubMed:29666258). Can also transport FAD across the mitochondrial inner membrane (PubMed:16165386). Indicus|evm.model.CM009504.1.443 Q96CG8 CTHR1_HUMAN 94.262 0.991837 1.00823 CTHRC1 - Collagen triple helix repeat-containing protein 1 precursor - Homo sapiens (Human) - CTHRC1 gene May act as a negative regulator of collagen matrix deposition. Indicus|evm.model.CM009504.1.444 Q8WMU5 FZD6_CANLF 90.294 0.997063 0.956461 FZD6 - Frizzled-6 precursor - Canis lupus familiaris (Dog) - FZD6 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). Indicus|evm.model.CM009504.1.445 Q8WNE9 BAALC_PIG 84.828 0.986301 1.0069 BAALC - Brain and acute leukemia cytoplasmic protein - Sus scrofa (Pig) - BAALC gene May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A. Indicus|evm.model.CM009504.1.447 P21282 VATC1_BOVIN 100.000 0.994778 1.00262 ATP6V1C1 - V-type proton ATPase subunit C 1 - Bos taurus (Bovine) - ATP6V1C1 gene Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Indicus|evm.model.CM009504.1.448 O14977 AZIN1_HUMAN 94.196 0.995546 1.00223 AZIN1 - Antizyme inhibitor 1 - Homo sapiens (Human) - AZIN1 gene Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Indicus|evm.model.CM009504.1.449 Q13118 KLF10_HUMAN 90.933 0.771084 1.0375 KLF10 - Krueppel-like factor 10 - Homo sapiens (Human) - KLF10 gene Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. Indicus|evm.model.CM009504.1.450 Q29438 ODFP1_BOVIN 100.000 0.992395 1.00382 ODF1 - Outer dense fiber protein 1 - Bos taurus (Bovine) - ODF1 gene Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. Indicus|evm.model.CM009504.1.451 O95071 UBR5_HUMAN 99.136 0.995688 0.994284 UBR5 - E3 ubiquitin-protein ligase UBR5 - Homo sapiens (Human) - UBR5 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. Indicus|evm.model.CM009504.1.452 Q5R9G0 RIR2B_PONAB 95.442 0.994318 1.00285 RRM2B - Ribonucleoside-diphosphate reductase subunit M2 B - Pongo abelii (Sumatran orangutan) - RRM2B gene Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage (By similarity). Indicus|evm.model.CM009504.1.453 Q5PQN0 NCALD_RAT 100.000 0.989691 1.00518 Ncald - Neurocalcin-delta - Rattus norvegicus (Rat) - Ncald gene May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). Indicus|evm.model.CM009504.1.454 Q6ISB3 GRHL2_HUMAN 95.427 0.631274 0.8288 GRHL2 - Grainyhead-like protein 2 homolog - Homo sapiens (Human) - GRHL2 gene Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:29309642, PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293). Indicus|evm.model.CM009504.1.455 Q9D115 ZN706_MOUSE 100.000 0.609756 1.61842 Znf706 - Zinc finger protein 706 - Mus musculus (Mouse) - Znf706 gene Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4. Indicus|evm.model.CM009504.1.456 Q5R651 1433Z_PONAB 100.000 0.953125 1.0449 YWHAZ - 14-3-3 protein zeta/delta - Pongo abelii (Sumatran orangutan) - YWHAZ gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). Indicus|evm.model.CM009504.1.457 P11940 PABP1_HUMAN 100.000 0.99686 1.00157 PABPC1 - Polyadenylate-binding protein 1 - Homo sapiens (Human) - PABPC1 gene Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). Indicus|evm.model.CM009504.1.458 Q8N9S9 SNX31_HUMAN 79.856 0.693632 1.32045 SNX31 - Sorting nexin-31 - Homo sapiens (Human) - SNX31 gene May be involved in protein trafficking. Indicus|evm.model.CM009504.1.459 Q86W74 ANR46_HUMAN 100.000 0.991266 1.00439 ANKRD46 - Ankyrin repeat domain-containing protein 46 - Homo sapiens (Human) - ANKRD46 gene Indicus|evm.model.CM009504.1.461 Q2VJ60 RN19A_PIG 97.852 0.997616 1.00119 RNF19A - E3 ubiquitin-protein ligase RNF19A - Sus scrofa (Pig) - RNF19A gene E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Indicus|evm.model.CM009504.1.462 Q07617 SPAG1_HUMAN 87.534 0.449204 0.882289 SPAG1 - Sperm-associated antigen 1 - Homo sapiens (Human) - SPAG1 gene May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. Indicus|evm.model.CM009504.1.463 P53803 RPAB4_HUMAN 92.727 0.782609 1.18966 POLR2K - DNA-directed RNA polymerases I, II, and III subunit RPABC4 - Homo sapiens (Human) - POLR2K gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Indicus|evm.model.CM009504.1.464 Q8NE09 RGS22_HUMAN 81.464 0.650653 1.51503 RGS22 - Regulator of G-protein signaling 22 - Homo sapiens (Human) - RGS22 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Indicus|evm.model.CM009504.1.465 Q7Z7G8 VP13B_HUMAN 90.456 0.998815 0.419692 VPS13B - Vacuolar protein sorting-associated protein 13B - Homo sapiens (Human) - VPS13B gene May be involved in protein sorting in post Golgi membrane traffic. Indicus|evm.model.CM009504.1.466 Q7Z7G8 VP13B_HUMAN 91.808 0.93977 0.280706 VPS13B - Vacuolar protein sorting-associated protein 13B - Homo sapiens (Human) - VPS13B gene May be involved in protein sorting in post Golgi membrane traffic. Indicus|evm.model.CM009504.1.468 Q7Z7G8 VP13B_HUMAN 92.959 0.991706 0.209846 VPS13B - Vacuolar protein sorting-associated protein 13B - Homo sapiens (Human) - VPS13B gene May be involved in protein sorting in post Golgi membrane traffic. Indicus|evm.model.CM009504.1.469 Q3T135 OSR2_BOVIN 99.606 0.808307 1.13406 OSR2 - Protein odd-skipped-related 2 - Bos taurus (Bovine) - OSR2 gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific DNA binding, bone morphogenesis, embryo development ending in birth or egg hatching, embryonic skeletal system morphogenesis, eyelid development in camera-type eye, mesonephros development, metanephros development Indicus|evm.model.CM009504.1.470 Q13188 STK3_HUMAN 99.282 0.995227 0.85336 STK3 - Serine/threonine-protein kinase 3 - Homo sapiens (Human) - STK3 gene Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38. Indicus|evm.model.CM009504.1.471 Q9ULS6 KCNS2_HUMAN 98.950 0.993724 1.0021 KCNS2 - Potassium voltage-gated channel subfamily S member 2 - Homo sapiens (Human) - KCNS2 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Indicus|evm.model.CM009504.1.473 Q6ZUA9 MROH5_HUMAN 68.044 0.963989 0.5478 MROH5 - Maestro heat-like repeat family member 5 - Homo sapiens (Human) - MROH5 gene Indicus|evm.model.CM009504.1.474 Q9H841 NPAL2_HUMAN 87.456 0.993056 0.751958 NIPAL2 - NIPA-like protein 2 - Homo sapiens (Human) - NIPAL2 gene membrane, magnesium ion transport Indicus|evm.model.CM009504.1.475 Q99575 POP1_HUMAN 80.762 0.998031 0.992188 POP1 - Ribonucleases P/MRP protein subunit POP1 - Homo sapiens (Human) - POP1 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:8918471, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). Indicus|evm.model.CM009504.1.476 Q3T114 RIDA_BOVIN 100.000 0.985507 1.0073 RIDA - 2-iminobutanoate/2-iminopropanoate deaminase - Bos taurus (Bovine) - RIDA gene Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. Indicus|evm.model.CM009504.1.477 Q08DY0 ERIC5_BOVIN 96.896 0.945378 1.05077 ERICH5 - Glutamate-rich protein 5 - Bos taurus (Bovine) - ERICH5 gene Indicus|evm.model.CM009504.1.478 P62890 RL30_RAT 100.000 0.982759 1.0087 Rpl30 - 60S ribosomal protein L30 - Rattus norvegicus (Rat) - Rpl30 gene cytosol, cytosolic large ribosomal subunit, nucleus, polysomal ribosome, postsynaptic density, ribosome, RNA binding, selenocysteine insertion sequence binding, structural constituent of ribosome, antimicrobial humoral immune response mediated by antimicrobial peptide Indicus|evm.model.CM009504.1.479 O00339 MATN2_HUMAN 91.348 0.988877 0.940377 MATN2 - Matrilin-2 precursor - Homo sapiens (Human) - MATN2 gene Involved in matrix assembly. Indicus|evm.model.CM009504.1.481 Q71SV0 LAP4B_BOVIN 99.558 0.991189 1.00442 LAPTM4B - Lysosomal-associated transmembrane protein 4B - Bos taurus (Bovine) - LAPTM4B gene Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. Indicus|evm.model.CM009504.1.482 Q86UE4 LYRIC_HUMAN 88.254 0.996743 1.05498 MTDH - Protein LYRIC - Homo sapiens (Human) - MTDH gene Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. Indicus|evm.model.CM009504.1.483 P62264 RS14_MOUSE 70.248 0.979381 0.642384 Rps14 - 40S ribosomal protein S14 - Mus musculus (Mouse) - Rps14 gene cytosol, cytosolic small ribosomal subunit, mitochondrion, nucleolus, postsynaptic density, mRNA 5'-UTR binding, RNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, translation regulator activity Indicus|evm.model.CM009504.1.484 P62752 RL23A_RAT 99.359 0.987261 1.00641 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009504.1.485 Q64152 BTF3_MOUSE 90.062 0.97546 0.79902 Btf3 - Transcription factor BTF3 - Mus musculus (Mouse) - Btf3 gene When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription (By similarity). Indicus|evm.model.CM009504.1.486 Q86VY4 TSYL5_HUMAN 88.426 0.990698 0.515588 TSPYL5 - Testis-specific Y-encoded-like protein 5 - Homo sapiens (Human) - TSPYL5 gene Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. Indicus|evm.model.CM009504.1.487 P31942 HNRH3_HUMAN 98.140 0.990741 0.624277 HNRNPH3 - Heterogeneous nuclear ribonucleoprotein H3 - Homo sapiens (Human) - HNRNPH3 gene Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. Indicus|evm.model.CM009504.1.489 Q17QK3 CBPQ_BOVIN 97.448 0.970655 0.938559 CPQ - Carboxypeptidase Q precursor - Bos taurus (Bovine) - CPQ gene Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor (By similarity). Indicus|evm.model.CM009504.1.491 Q58DD4 SDC2_BOVIN 100.000 0.990148 1.00495 SDC2 - Syndecan-2 precursor - Bos taurus (Bovine) - SDC2 gene Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). Indicus|evm.model.CM009504.1.492 Q2KHY9 PTSS1_BOVIN 100.000 0.995614 0.964059 PTDSS1 - Phosphatidylserine synthase 1 - Bos taurus (Bovine) - PTDSS1 gene Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity). Indicus|evm.model.CM009504.1.493 Q96E29 MTEF3_HUMAN 83.483 0.873684 0.911271 MTERF3 - Transcription termination factor 3, mitochondrial precursor - Homo sapiens (Human) - MTERF3 gene Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity). Indicus|evm.model.CM009504.1.494 P00129 QCR7_BOVIN 100.000 0.352697 2.17117 UQCRB - Cytochrome b-c1 complex subunit 7 - Bos taurus (Bovine) - UQCRB gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Indicus|evm.model.CM009504.1.495 P55106 GDF6_BOVIN 99.296 0.21267 1.41064 GDF6 - Growth/differentiation factor 6 precursor - Bos taurus (Bovine) - GDF6 gene Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38. Indicus|evm.model.CM009504.1.497 Q4R7Y2 RL10_MACFA 74.627 0.381503 0.808411 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009504.1.498 E1BC52 CH037_BOVIN 100.000 0.990385 1.00483 Protein C8orf37 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009504.1.499 Q9H8W4 PKHF2_HUMAN 98.394 0.992 1.00402 PLEKHF2 - Pleckstrin homology domain-containing family F member 2 - Homo sapiens (Human) - PLEKHF2 gene May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). Indicus|evm.model.CM009504.1.500 A7YVD7 NDUF6_BOVIN 100.000 0.994012 1.003 NDUFAF6 - NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor - Bos taurus (Bovine) - NDUFAF6 gene Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of complex I subunit MT-ND1. Indicus|evm.model.CM009504.1.501 Q96A56 T53I1_HUMAN 90.833 0.677054 1.47083 TP53INP1 - Tumor protein p53-inducible nuclear protein 1 - Homo sapiens (Human) - TP53INP1 gene Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. Indicus|evm.model.CM009504.1.502 Q4V847 INT8_XENLA 88.779 0.705607 0.431887 ints8 - Integrator complex subunit 8 - Xenopus laevis (African clawed frog) - ints8 gene Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Indicus|evm.model.CM009504.1.503 Q5E9K7 CCNE2_BOVIN 98.039 0.342637 2.57178 CCNE2 - G1/S-specific cyclin-E2 - Bos taurus (Bovine) - CCNE2 gene Essential for the control of the cell cycle at the late G1 and early S phase. Indicus|evm.model.CM009504.1.504 Q5R8N9 D19L4_PONAB 95.735 0.937845 1.05539 DPY19L4 - Probable C-mannosyltransferase DPY19L4 - Pongo abelii (Sumatran orangutan) - DPY19L4 gene Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Indicus|evm.model.CM009504.1.505 Q6NXG1 ESRP1_HUMAN 97.210 0.997067 1.00147 ESRP1 - Epithelial splicing regulatory protein 1 - Homo sapiens (Human) - ESRP1 gene mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). Indicus|evm.model.CM009504.1.506 Q69YN4 VIR_HUMAN 97.737 0.998897 1.00055 VIRMA - Protein virilizer homolog - Homo sapiens (Human) - VIRMA gene Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). Indicus|evm.model.CM009504.1.507 Q9Y620 RA54B_HUMAN 85.699 0.962845 1.03516 RAD54B - DNA repair and recombination protein RAD54B - Homo sapiens (Human) - RAD54B gene Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. Indicus|evm.model.CM009504.1.508 P55040 GEM_HUMAN 94.595 0.945513 1.05405 GEM - GTP-binding protein GEM - Homo sapiens (Human) - GEM gene Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Indicus|evm.model.CM009504.1.509 Q12864 CAD17_HUMAN 78.005 0.997599 1.0012 CDH17 - Cadherin-17 precursor - Homo sapiens (Human) - CDH17 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. Indicus|evm.model.CM009504.1.510 P35816 PDP1_BOVIN 99.814 0.952128 1.04833 PDP1 - [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial precursor - Bos taurus (Bovine) - PDP1 gene Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. Indicus|evm.model.CM009504.1.511 P61959 SUMO2_RAT 80.000 0.467153 1.44211 Sumo2 - Small ubiquitin-related modifier 2 precursor - Rattus norvegicus (Rat) - Sumo2 gene Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). Indicus|evm.model.CM009504.1.512 Q5HYA8 MKS3_HUMAN 86.100 0.998002 1.00603 TMEM67 - Meckelin precursor - Homo sapiens (Human) - TMEM67 gene Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Indicus|evm.model.CM009504.1.513 Q8IXT5 RB12B_HUMAN 84.915 0.99797 0.984016 RBM12B - RNA-binding protein 12B - Homo sapiens (Human) - RBM12B gene nucleoplasm, ribonucleoprotein complex, RNA binding, regulation of RNA splicing Indicus|evm.model.CM009504.1.514 Q3SZG6 FA92A_BOVIN 98.566 0.982206 0.975694 FAM92A - Protein FAM92A - Bos taurus (Bovine) - FAM92A gene Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis. In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis. Indicus|evm.model.CM009504.1.515 Q07817 B2CL1_HUMAN 65.101 0.977778 0.579399 BCL2L1 - Bcl-2-like protein 1 - Homo sapiens (Human) - BCL2L1 gene Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Indicus|evm.model.CM009504.1.517 Q5RDR6 TRIQK_PONAB 98.077 0.31677 1.87209 TRIQK - Triple QxxK/R motif-containing protein - Pongo abelii (Sumatran orangutan) - TRIQK gene May play a role in cell growth and maintenance of cell morphology. Indicus|evm.model.CM009504.1.518 Q06455 MTG8_HUMAN 99.007 0.996689 1 RUNX1T1 - Protein CBFA2T1 - Homo sapiens (Human) - RUNX1T1 gene Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). Indicus|evm.model.CM009504.1.519 Q8TE54 S26A7_HUMAN 82.055 0.996587 0.893293 SLC26A7 - Anion exchange transporter - Homo sapiens (Human) - SLC26A7 gene Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. Indicus|evm.model.CM009504.1.520 Q6ZNQ3 LRC69_HUMAN 75.556 0.985294 0.391931 LRRC69 - Leucine-rich repeat-containing protein 69 - Homo sapiens (Human) - LRRC69 gene signal transduction Indicus|evm.model.CM009504.1.521 Q9D9Q0 LRC69_MOUSE 73.000 0.916667 0.311239 Lrrc69 - Leucine-rich repeat-containing protein 69 - Mus musculus (Mouse) - Lrrc69 gene signal transduction Indicus|evm.model.CM009504.1.522 Q8N6M0 OTU6B_HUMAN 90.444 0.993197 1.00341 OTUD6B - Deubiquitinase OTUD6B - Homo sapiens (Human) - OTUD6B gene Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629). Indicus|evm.model.CM009504.1.523 Q3SZ48 PP4P2_BOVIN 92.692 0.992063 0.980545 PIP4P2 - Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase - Bos taurus (Bovine) - PIP4P2 gene Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity). Indicus|evm.model.CM009504.1.524 P0DMB2 CH088_HUMAN 94.872 0.966387 1.01709 C8orf88 - Uncharacterized protein C8orf88 - Homo sapiens (Human) - C8orf88 gene cytoplasm, eukaryotic initiation factor 4E binding, negative regulation of translational initiation Indicus|evm.model.CM009504.1.525 P27117 DCOR_BOVIN 89.041 0.956621 0.950108 ODC1 - Ornithine decarboxylase - Bos taurus (Bovine) - ODC1 gene Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Indicus|evm.model.CM009504.1.526 Q6YI46 TMM64_HUMAN 93.727 0.911864 0.776316 TMEM64 - Transmembrane protein 64 - Homo sapiens (Human) - TMEM64 gene Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1. Indicus|evm.model.CM009504.1.527 P04467 CALB1_BOVIN 100.000 0.992366 1.00383 CALB1 - Calbindin - Bos taurus (Bovine) - CALB1 gene Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Indicus|evm.model.CM009504.1.528 Q16698 DECR_HUMAN 90.566 0.960606 0.985075 DECR1 - 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial precursor - Homo sapiens (Human) - DECR1 gene Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Indicus|evm.model.CM009504.1.529 O60934 NBN_HUMAN 78.732 0.997351 1.00133 NBN - Nibrin - Homo sapiens (Human) - NBN gene Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex. Indicus|evm.model.CM009504.1.530 Q9Y236 OSGI2_HUMAN 92.095 0.996055 1.00396 OSGIN2 - Oxidative stress-induced growth inhibitor 2 - Homo sapiens (Human) - OSGIN2 gene May be involved in meiosis or the maturation of germ cells. Indicus|evm.model.CM009504.1.531 Q3SZJ2 RIPK2_BOVIN 91.351 0.983957 0.346296 RIPK2 - Receptor-interacting serine/threonine-protein kinase 2 - Bos taurus (Bovine) - RIPK2 gene Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is release from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (By similarity). Plays a role in the inactivation of RHOA in response to NGFR signaling (By similarity). Indicus|evm.model.CM009504.1.532 Q3SZJ2 RIPK2_BOVIN 99.721 0.959677 0.688889 RIPK2 - Receptor-interacting serine/threonine-protein kinase 2 - Bos taurus (Bovine) - RIPK2 gene Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is release from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (By similarity). Plays a role in the inactivation of RHOA in response to NGFR signaling (By similarity). Indicus|evm.model.CM009504.1.534 P51512 MMP16_HUMAN 99.016 0.938889 0.889621 MMP16 - Matrix metalloproteinase-16 precursor - Homo sapiens (Human) - MMP16 gene Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. Indicus|evm.model.CM009504.1.535 P58353 GTR5_BOVIN 100.000 0.95 0.399202 SLC2A5 - Solute carrier family 2, facilitated glucose transporter member 5 - Bos taurus (Bovine) - SLC2A5 gene Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake. Indicus|evm.model.CM009504.1.536 Q9JIK5 DDX21_MOUSE 58.614 0.808743 0.645123 Ddx21 - Nucleolar RNA helicase 2 - Mus musculus (Mouse) - Ddx21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (By similarity). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (By similarity). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification (By similarity). Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (By similarity). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (By similarity). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (By similarity). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (By similarity). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (By similarity). Involved in rRNA processing. May bind to specific miRNA hairpins (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (PubMed:21703541). Indicus|evm.model.CM009504.1.537 Q8NA66 CNBD1_HUMAN 71.659 0.835294 1.16972 CNBD1 - Cyclic nucleotide-binding domain-containing protein 1 - Homo sapiens (Human) - CNBD1 gene Indicus|evm.model.CM009504.1.538 Q8MJD7 CNGB3_CANLF 80.118 0.963072 0.865729 CNGB3 - Cyclic nucleotide-gated cation channel beta-3 - Canis lupus familiaris (Dog) - CNGB3 gene Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Indicus|evm.model.CM009504.1.539 O75131 CPNE3_HUMAN 95.310 0.915663 1.08194 CPNE3 - Copine-3 - Homo sapiens (Human) - CPNE3 gene Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870). Indicus|evm.model.CM009504.1.540 Q32KL4 RMD1_BOVIN 99.685 0.993711 1.00315 RMDN1 - Regulator of microtubule dynamics protein 1 - Bos taurus (Bovine) - RMDN1 gene cytoplasm, mitotic spindle pole, spindle microtubule, microtubule binding Indicus|evm.model.CM009504.1.541 Q9H0M0 WWP1_HUMAN 93.601 0.997831 1 WWP1 - NEDD4-like E3 ubiquitin-protein ligase WWP1 - Homo sapiens (Human) - WWP1 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Indicus|evm.model.CM009504.1.542 P40925 MDHC_HUMAN 47.143 0.722892 0.497006 MDH1 - Malate dehydrogenase, cytoplasmic - Homo sapiens (Human) - MDH1 gene Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Indicus|evm.model.CM009504.1.543 Q2KJB6 VA0D2_BOVIN 99.482 0.673684 0.811966 ATP6V0D2 - V-type proton ATPase subunit d 2 - Bos taurus (Bovine) - ATP6V0D2 gene Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Indicus|evm.model.CM009504.1.545 P00921 CAH2_BOVIN 100.000 0.990148 0.780769 CA2 - Carbonic anhydrase 2 - Bos taurus (Bovine) - CA2 gene Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Indicus|evm.model.CM009504.1.547 Q3SZX4 CAH3_BOVIN 100.000 0.992337 1.00385 CA3 - Carbonic anhydrase 3 - Bos taurus (Bovine) - CA3 gene Reversible hydration of carbon dioxide. Indicus|evm.model.CM009504.1.548 Q1LZA1 CAH1_BOVIN 100.000 0.992366 1.00383 CA1 - Carbonic anhydrase 1 - Bos taurus (Bovine) - CA1 gene Reversible hydration of carbon dioxide. Indicus|evm.model.CM009504.1.549 Q1LZA1 CAH1_BOVIN 96.935 0.992366 1.00383 CA1 - Carbonic anhydrase 1 - Bos taurus (Bovine) - CA1 gene Reversible hydration of carbon dioxide. Indicus|evm.model.CM009504.1.550 Q1LZA1 CAH1_BOVIN 97.143 0.621622 0.425287 CA1 - Carbonic anhydrase 1 - Bos taurus (Bovine) - CA1 gene Reversible hydration of carbon dioxide. Indicus|evm.model.CM009504.1.551 Q9D6N1 CAH13_MOUSE 90.763 0.807818 1.17176 Ca13 - Carbonic anhydrase 13 - Mus musculus (Mouse) - Ca13 gene Reversible hydration of carbon dioxide. Indicus|evm.model.CM009504.1.552 Q8N0T1 RBIS_HUMAN 83.000 0.980198 1.01 RBIS - Ribosomal biogenesis factor - Homo sapiens (Human) - RBIS gene Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production. Indicus|evm.model.CM009504.1.553 Q15329 E2F5_HUMAN 86.617 0.805112 0.904624 E2F5 - Transcription factor E2F5 - Homo sapiens (Human) - E2F5 gene Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Indicus|evm.model.CM009504.1.554 Q9C099 LRCC1_HUMAN 83.399 0.988327 0.996124 LRRCC1 - Leucine-rich repeat and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - LRRCC1 gene Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis. Indicus|evm.model.CM009504.1.555 Q91WN3 S7A13_MOUSE 52.878 0.977035 1.00209 Slc7a13 - Solute carrier family 7 member 13 - Mus musculus (Mouse) - Slc7a13 gene Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner. Indicus|evm.model.CM009504.1.556 Q5RKI7 S7A13_RAT 54.757 0.961303 1.02505 Slc7a13 - Solute carrier family 7 member 13 - Rattus norvegicus (Rat) - Slc7a13 gene Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner. Indicus|evm.model.CM009504.1.557 P42558 RAN_CHICK 58.261 0.91129 0.574074 RAN - GTP-binding nuclear protein Ran - Gallus gallus (Chicken) - RAN gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. Indicus|evm.model.CM009504.1.563 Q3ZCJ7 TBA1C_BOVIN 92.308 0.6375 0.178174 TUBA1C - Tubulin alpha-1C chain - Bos taurus (Bovine) - TUBA1C gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Indicus|evm.model.CM009504.1.564 P08537 TBA_XENLA 89.535 0.97561 0.182628 tuba - Tubulin alpha chain - Xenopus laevis (African clawed frog) - tuba gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009504.1.565 P57768 SNX16_HUMAN 88.630 0.994186 1 SNX16 - Sorting nexin-16 - Homo sapiens (Human) - SNX16 gene May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. Indicus|evm.model.CM009504.1.566 Q96CF2 CHM4C_HUMAN 88.559 0.991561 1.01717 CHMP4C - Charged multivesicular body protein 4c - Homo sapiens (Human) - CHMP4C gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission (PubMed:22422861, PubMed:24814515). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Indicus|evm.model.CM009504.1.567 Q8TCF1 ZFAN1_HUMAN 86.567 0.992565 1.00373 ZFAND1 - AN1-type zinc finger protein 1 - Homo sapiens (Human) - ZFAND1 gene Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830). Indicus|evm.model.CM009504.1.568 Q5PT55 NTCP5_HUMAN 77.480 0.661319 1.28082 SLC10A5 - Sodium/bile acid cotransporter 5 precursor - Homo sapiens (Human) - SLC10A5 gene bile acid:sodium symporter activity, bile acid and bile salt transport Indicus|evm.model.CM009504.1.569 P20456 IMPA1_BOVIN 100.000 0.992806 1.00361 IMPA1 - Inositol monophosphatase 1 - Bos taurus (Bovine) - IMPA1 gene Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate. Indicus|evm.model.CM009504.1.570 A1A4K5 ENPP2_BOVIN 99.772 0.996587 0.989865 ENPP2 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 precursor - Bos taurus (Bovine) - ENPP2 gene Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine (PubMed:12119361). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor (By similarity). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity). Indicus|evm.model.CM009504.1.571 Q8C176 TAF2_MOUSE 97.325 0.792007 1.11051 Taf2 - Transcription initiation factor TFIID subunit 2 - Mus musculus (Mouse) - Taf2 gene Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter (By similarity). Indicus|evm.model.CM009504.1.572 Q9BVC3 DCC1_HUMAN 90.691 0.698947 1.20865 DSCC1 - Sister chromatid cohesion protein DCC1 - Homo sapiens (Human) - DSCC1 gene Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3. Indicus|evm.model.CM009504.1.573 Q8TB45 DPTOR_HUMAN 91.883 0.693878 1.07824 DEPTOR - DEP domain-containing mTOR-interacting protein - Homo sapiens (Human) - DEPTOR gene Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes. Indicus|evm.model.CM009504.1.575 Q05707 COEA1_HUMAN 88.147 0.994869 0.976615 COL14A1 - Collagen alpha-1(XIV) chain precursor - Homo sapiens (Human) - COL14A1 gene Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). Indicus|evm.model.CM009504.1.577 Q3SYS1 RM13_BOVIN 100.000 0.988827 1.00562 MRPL13 - 39S ribosomal protein L13, mitochondrial - Bos taurus (Bovine) - MRPL13 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, ribosome, mRNA binding, structural constituent of ribosome, negative regulation of translation Indicus|evm.model.CM009504.1.578 Q96DY7 MTBP_HUMAN 80.221 0.997775 0.994469 MTBP - Mdm2-binding protein - Homo sapiens (Human) - MTBP gene Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Indicus|evm.model.CM009504.1.579 Q13884 SNTB1_HUMAN 76.796 0.822323 0.815985 SNTB1 - Beta-1-syntrophin - Homo sapiens (Human) - SNTB1 gene Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. Indicus|evm.model.CM009504.1.580 Q13884 SNTB1_HUMAN 92.929 0.328859 0.553903 SNTB1 - Beta-1-syntrophin - Homo sapiens (Human) - SNTB1 gene Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. Indicus|evm.model.CM009505.1.1 Q13136 LIPA1_HUMAN 57.971 0.981651 0.0906822 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009505.1.2 Q8NH72 OR4C6_HUMAN 65.217 0.958115 0.618123 OR4C6 - Olfactory receptor 4C6 - Homo sapiens (Human) - OR4C6 gene Odorant receptor. Indicus|evm.model.CM009505.1.4 Q60878 OL140_MOUSE 56.566 0.82906 0.387417 Olfr140 - Olfactory receptor 140 - Mus musculus (Mouse) - Olfr140 gene Odorant receptor. Indicus|evm.model.CM009505.1.5 Q8NGL9 OR4CG_HUMAN 75.200 0.953846 0.419355 OR4C16 - Olfactory receptor 4C16 - Homo sapiens (Human) - OR4C16 gene Odorant receptor. Indicus|evm.model.CM009505.1.7 Q8NGL7 OR4P4_HUMAN 54.605 0.904192 0.535256 OR4P4 - Olfactory receptor 4P4 - Homo sapiens (Human) - OR4P4 gene Odorant receptor. Indicus|evm.model.CM009505.1.8 Q96RD7 PANX1_HUMAN 61.765 0.821053 0.446009 PANX1 - Pannexin-1 - Homo sapiens (Human) - PANX1 gene Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). Plays a critical role in oogenesis (PubMed:30918116). Indicus|evm.model.CM009505.1.9 Q9EQF4 JUNO_MOUSE 68.421 0.807143 0.57377 Izumo1r - Sperm-egg fusion protein Juno precursor - Mus musculus (Mouse) - Izumo1r gene Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization (PubMed:24739963, PubMed:26859261, PubMed:27309808, PubMed:27416963). The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:24739963, PubMed:26859261, PubMed:27309808). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:24739963, PubMed:26859261, PubMed:27309808). Does not bind folate (PubMed:24739963). Indicus|evm.model.CM009505.1.10 Q9NYM4 GPR83_HUMAN 91.358 0.96875 0.983452 GPR83 - Probable G-protein coupled receptor 83 precursor - Homo sapiens (Human) - GPR83 gene Orphan receptor. Could be a neuropeptide Y receptor. Indicus|evm.model.CM009505.1.11 P49959 MRE11_HUMAN 85.789 0.997368 1.07345 MRE11 - Double-strand break repair protein MRE11 - Homo sapiens (Human) - MRE11 gene Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289, PubMed:30612738). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). Indicus|evm.model.CM009505.1.12 Q5EA33 ANR49_BOVIN 99.160 0.991632 1.0042 ANKRD49 - Ankyrin repeat domain-containing protein 49 - Bos taurus (Bovine) - ANKRD49 gene May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway. Indicus|evm.model.CM009505.1.13 Q9NRN7 ADPPT_HUMAN 93.204 0.993548 1.00324 AASDHPPT - L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase - Homo sapiens (Human) - AASDHPPT gene Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN. Indicus|evm.model.CM009505.1.14 Q8NAB2 KBTB3_HUMAN 95.207 0.993421 0.993464 KBTBD3 - Kelch repeat and BTB domain-containing protein 3 - Homo sapiens (Human) - KBTBD3 gene Indicus|evm.model.CM009505.1.15 Q2KJB9 MSD4_BOVIN 100.000 0.99422 1.0029 MSANTD4 - Myb/SANT-like DNA-binding domain-containing protein 4 - Bos taurus (Bovine) - MSANTD4 gene Indicus|evm.model.CM009505.1.16 P48058 GRIA4_HUMAN 99.630 0.990826 0.604213 GRIA4 - Glutamate receptor 4 precursor - Homo sapiens (Human) - GRIA4 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Indicus|evm.model.CM009505.1.17 P19493 GRIA4_RAT 96.721 0.983607 0.0676275 Gria4 - Glutamate receptor 4 precursor - Rattus norvegicus (Rat) - Gria4 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Indicus|evm.model.CM009505.1.18 Q148I1 PAAF1_BOVIN 90.756 0.975207 0.308673 PAAF1 - Proteasomal ATPase-associated factor 1 - Bos taurus (Bovine) - PAAF1 gene Inhibits proteasome 26S assembly and activity by impairing the association of the 19S regulatory complex with the 20S core. Protects SUPT6H from proteasomal degradation (By similarity). Indicus|evm.model.CM009505.1.21 O75601 CASPD_BOVIN 100.000 0.460784 2.16446 CASP13 - Caspase-13 precursor - Bos taurus (Bovine) - CASP13 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Indicus|evm.model.CM009505.1.22 B0VXE8 CDK14_CALJA 85.075 0.578947 0.269504 CDK14 - Cyclin-dependent kinase 14 - Callithrix jacchus (White-tufted-ear marmoset) - CDK14 gene Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity). Indicus|evm.model.CM009505.1.23 Q3ZCX4 ZN568_HUMAN 50.568 0.690945 0.78882 ZNF568 - Zinc finger protein 568 - Homo sapiens (Human) - ZNF568 gene Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells. Indicus|evm.model.CM009505.1.25 Q6V9H4 PDGFD_RABIT 94.333 0.80593 1.23667 PDGFD - Platelet-derived growth factor D precursor - Oryctolagus cuniculus (Rabbit) - PDGFD gene Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). Indicus|evm.model.CM009505.1.27 Q8NCM8 DYHC2_HUMAN 93.297 0.538594 0.944509 DYNC2H1 - Cytoplasmic dynein 2 heavy chain 1 - Homo sapiens (Human) - DYNC2H1 gene May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). Indicus|evm.model.CM009505.1.28 Q1RMX9 DCNL5_BOVIN 100.000 0.991561 1.00424 DCUN1D5 - DCN1-like protein 5 - Bos taurus (Bovine) - DCUN1D5 gene Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate to cell proliferation and anchorage-independent cell growth. Indicus|evm.model.CM009505.1.29 O77656 MMP13_BOVIN 99.363 0.995763 1.00212 MMP13 - Collagenase 3 precursor - Bos taurus (Bovine) - MMP13 gene Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion (By similarity). Indicus|evm.model.CM009505.1.31 P08254 MMP3_HUMAN 81.450 0.53303 1.84067 MMP3 - Stromelysin-1 precursor - Homo sapiens (Human) - MMP3 gene Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Indicus|evm.model.CM009505.1.32 P28053 MMP1_BOVIN 98.015 0.29386 2.91684 MMP1 - Interstitial collagenase precursor - Bos taurus (Bovine) - MMP1 gene Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. Indicus|evm.model.CM009505.1.33 Q9GKE1 MMP27_TUPBE 83.433 0.974609 1 MMP27 - Matrix metalloproteinase-27 precursor - Tupaia belangeri (Common tree shrew) - MMP27 gene Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens. Indicus|evm.model.CM009505.1.34 O18767 MMP20_BOVIN 83.576 0.990476 0.873181 MMP20 - Matrix metalloproteinase-20 precursor - Bos taurus (Bovine) - MMP20 gene Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Ser-|-Phe-361' site. Indicus|evm.model.CM009505.1.35 P09237 MMP7_HUMAN 74.046 0.949091 1.02996 MMP7 - Matrilysin precursor - Homo sapiens (Human) - MMP7 gene Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Indicus|evm.model.CM009505.1.36 Q8N131 PORIM_HUMAN 70.968 0.337176 1.66827 TMEM123 - Porimin precursor - Homo sapiens (Human) - TMEM123 gene Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. Indicus|evm.model.CM009505.1.37 Q13490 BIRC2_HUMAN 89.179 0.996269 0.867314 BIRC2 - Baculoviral IAP repeat-containing protein 2 - Homo sapiens (Human) - BIRC2 gene Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. Indicus|evm.model.CM009505.1.38 O62640 PIAP_PIG 77.831 0.712565 1.62291 PIAP - Putative inhibitor of apoptosis - Sus scrofa (Pig) - PIAP gene cytoplasm, nucleus, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ubiquitin protein ligase activity, negative regulation of apoptotic process, negative regulation of necroptotic process, positive regulation of protein ubiquitination, regulation of cell cycle Indicus|evm.model.CM009505.1.39 P46937 YAP1_HUMAN 98.741 0.635634 1.23611 YAP1 - Transcriptional coactivator YAP1 - Homo sapiens (Human) - YAP1 gene Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750). Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Indicus|evm.model.CM009505.1.40 Q9P2H0 CE126_HUMAN 71.550 0.86741 0.722471 CEP126 - Centrosomal protein of 126 kDa - Homo sapiens (Human) - CEP126 gene Participates in cytokinesis (PubMed:19799413). Necessary for microtubules and mitotic spindle organization (PubMed:24867236). Involved in primary cilium formation (PubMed:24867236). Indicus|evm.model.CM009505.1.41 Q9P2H0 CE126_HUMAN 76.630 0.470284 0.346464 CEP126 - Centrosomal protein of 126 kDa - Homo sapiens (Human) - CEP126 gene Participates in cytokinesis (PubMed:19799413). Necessary for microtubules and mitotic spindle organization (PubMed:24867236). Involved in primary cilium formation (PubMed:24867236). Indicus|evm.model.CM009505.1.42 Q86XS5 ANGL5_HUMAN 87.696 0.987047 0.994845 ANGPTL5 - Angiopoietin-related protein 5 precursor - Homo sapiens (Human) - ANGPTL5 gene collagen-containing extracellular matrix, extracellular space Indicus|evm.model.CM009505.1.43 Q64361 LXN_RAT 77.679 0.973684 0.511211 Lxn - Latexin - Rattus norvegicus (Rat) - Lxn gene Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation (By similarity). Indicus|evm.model.CM009505.1.44 Q9MYW0 TRPC6_BOVIN 100.000 0.997639 0.909774 TRPC6 - Short transient receptor potential channel 6 - Bos taurus (Bovine) - TRPC6 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Indicus|evm.model.CM009505.1.46 P06186 PRGR_RABIT 65.241 0.935065 0.413978 PGR - Progesterone receptor - Oryctolagus cuniculus (Rabbit) - PGR gene The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Indicus|evm.model.CM009505.1.48 A6NI28 RHG42_HUMAN 95.309 0.997658 0.977117 ARHGAP42 - Rho GTPase-activating protein 42 - Homo sapiens (Human) - ARHGAP42 gene May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. Indicus|evm.model.CM009505.1.50 Q58DQ3 RL6_BOVIN 98.258 0.993056 1.00348 RPL6 - 60S ribosomal protein L6 - Bos taurus (Bovine) - RPL6 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009505.1.52 O94779 CNTN5_HUMAN 87.928 0.960155 0.935455 CNTN5 - Contactin-5 precursor - Homo sapiens (Human) - CNTN5 gene Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity). Indicus|evm.model.CM009505.1.54 Q99880 H2B1L_HUMAN 88.889 0.984252 1.00794 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009505.1.56 B2RRL2 JERKL_MOUSE 98.387 0.44086 0.533461 Jrkl - Jerky protein homolog-like - Mus musculus (Mouse) - Jrkl gene nucleus, DNA binding Indicus|evm.model.CM009505.1.57 Q8N4S0 CCD82_HUMAN 72.152 0.996176 0.961397 CCDC82 - Coiled-coil domain-containing protein 82 - Homo sapiens (Human) - CCDC82 gene nucleus Indicus|evm.model.CM009505.1.58 A5D7F6 MAML2_BOVIN 100.000 0.669261 0.227837 MAML2 - Mastermind-like protein 2 - Bos taurus (Bovine) - MAML2 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3 (By similarity). Indicus|evm.model.CM009505.1.60 A5D7F6 MAML2_BOVIN 98.646 0.864322 0.529255 MAML2 - Mastermind-like protein 2 - Bos taurus (Bovine) - MAML2 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3 (By similarity). Indicus|evm.model.CM009505.1.61 A5D7F6 MAML2_BOVIN 100.000 0.993377 0.26773 MAML2 - Mastermind-like protein 2 - Bos taurus (Bovine) - MAML2 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3 (By similarity). Indicus|evm.model.CM009505.1.62 A6QLT2 MTMR2_BOVIN 99.838 0.966981 0.989114 MTMR2 - Myotubularin-related protein 2 - Bos taurus (Bovine) - MTMR2 gene Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Stabilizes SBF2/MTMR13 at the membranes. Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity). Indicus|evm.model.CM009505.1.63 Q865V0 CEP57_BOVIN 99.800 0.996 1.002 CEP57 - Centrosomal protein of 57 kDa - Bos taurus (Bovine) - CEP57 gene Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2 (By similarity). Indicus|evm.model.CM009505.1.64 Q5HYJ3 FA76B_HUMAN 99.115 0.994118 1.00295 FAM76B - Protein FAM76B - Homo sapiens (Human) - FAM76B gene nuclear speck Indicus|evm.model.CM009505.1.65 Q3T075 STX8_BOVIN 96.078 0.980392 0.216102 STX8 - Syntaxin-8 - Bos taurus (Bovine) - STX8 gene Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. Indicus|evm.model.CM009505.1.68 P58005 SESN3_HUMAN 98.927 0.995717 0.949187 SESN3 - Sestrin-3 - Homo sapiens (Human) - SESN3 gene May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). Indicus|evm.model.CM009505.1.69 O94919 ENDD1_HUMAN 76.074 0.974052 1.002 ENDOD1 - Endonuclease domain-containing 1 protein precursor - Homo sapiens (Human) - ENDOD1 gene May act as a DNase and a RNase. Indicus|evm.model.CM009505.1.70 A1A5Q5 KDM4D_RAT 85.616 0.889571 0.319608 Kdm4d - Lysine-specific demethylase 4D - Rattus norvegicus (Rat) - Kdm4d gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Indicus|evm.model.CM009505.1.71 Q6B0I6 KDM4D_HUMAN 82.418 0.848131 0.818356 KDM4D - Lysine-specific demethylase 4D - Homo sapiens (Human) - KDM4D gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Indicus|evm.model.CM009505.1.72 F1N5S9 FUND1_BOVIN 60.000 0.980769 0.670968 FUNDC1 - FUN14 domain-containing protein 1 - Bos taurus (Bovine) - FUNDC1 gene Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Indicus|evm.model.CM009505.1.73 B2RXH2 KDM4E_HUMAN 71.355 0.768463 0.990119 KDM4E - Lysine-specific demethylase 4E - Homo sapiens (Human) - KDM4E gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Indicus|evm.model.CM009505.1.74 Q2KJD3 CWC15_BOVIN 100.000 0.991379 1.00433 CWC15 - Spliceosome-associated protein CWC15 homolog - Bos taurus (Bovine) - CWC15 gene Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Indicus|evm.model.CM009505.1.75 E1BEQ5 AMOL1_BOVIN 99.788 0.848375 1.15417 AMOTL1 - Angiomotin-like protein 1 - Bos taurus (Bovine) - AMOTL1 gene Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Indicus|evm.model.CM009505.1.76 Q7Z3Z4 PIWL4_HUMAN 81.081 0.974448 1.01056 PIWIL4 - Piwi-like protein 4 - Homo sapiens (Human) - PIWIL4 gene Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Does not show endonuclease activity (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci (PubMed:17544373). In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities. Plays a role in pancreatic beta cell function and insulin secretion (By similarity). Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (PubMed:28025795). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of cells proliferation in tumors (PubMed:22483988). Indicus|evm.model.CM009505.1.77 Q8HZR3 FUT4_BOVIN 99.635 0.992727 0.690955 FUT4 - Alpha-(1,3)-fucosyltransferase 4 - Bos taurus (Bovine) - FUT4 gene May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens. Indicus|evm.model.CM009505.1.78 F1MQW7 CK097_BOVIN 99.206 0.984252 1.00794 Uncharacterized protein C11orf97 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009505.1.79 Q2TBE0 C19L2_HUMAN 78.363 0.995343 0.96085 CWF19L2 - CWF19-like protein 2 - Homo sapiens (Human) - CWF19L2 gene post-mRNA release spliceosomal complex, mRNA splicing, via spliceosome Indicus|evm.model.CM009505.1.80 P33402 GCYA2_HUMAN 92.045 0.940959 0.740437 GUCY1A2 - Guanylate cyclase soluble subunit alpha-2 - Homo sapiens (Human) - GUCY1A2 gene Has guanylyl cyclase on binding to the beta-1 subunit. Indicus|evm.model.CM009505.1.81 A1A4L5 ALKB8_BOVIN 98.084 0.361111 1.08434 ALKBH8 - Alkylated DNA repair protein alkB homolog 8 - Bos taurus (Bovine) - ALKBH8 gene Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity). Indicus|evm.model.CM009505.1.83 Q0IIE6 ELMD1_BOVIN 100.000 0.993884 1.00307 ELMOD1 - ELMO domain-containing protein 1 - Bos taurus (Bovine) - ELMOD1 gene Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Indicus|evm.model.CM009505.1.84 Q8IXU6 S35F2_HUMAN 93.048 0.994609 0.991979 SLC35F2 - Solute carrier family 35 member F2 - Homo sapiens (Human) - SLC35F2 gene Putative solute transporter. Indicus|evm.model.CM009505.1.85 Q14964 RB39A_HUMAN 98.618 0.990826 1.00461 RAB39A - Ras-related protein Rab-39A - Homo sapiens (Human) - RAB39A gene Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (PubMed:24349490). May be involved in multiple neurite formation (By similarity). Indicus|evm.model.CM009505.1.86 Q93034 CUL5_HUMAN 100.000 0.997439 1.00128 CUL5 - Cullin-5 - Homo sapiens (Human) - CUL5 gene Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. Indicus|evm.model.CM009505.1.87 Q29RZ0 THIL_BOVIN 100.000 0.905376 1.1019 ACAT1 - Acetyl-CoA acetyltransferase, mitochondrial precursor - Bos taurus (Bovine) - ACAT1 gene This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Indicus|evm.model.CM009505.1.88 Q14207 NPAT_HUMAN 80.319 0.998605 1.00491 NPAT - Protein NPAT - Homo sapiens (Human) - NPAT gene Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. Indicus|evm.model.CM009505.1.89 Q13315 ATM_HUMAN 89.791 0.999345 0.999673 ATM - Serine-protein kinase ATM - Homo sapiens (Human) - ATM gene Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:9843217, PubMed:9733515, PubMed:10550055, PubMed:10766245, PubMed:10839545, PubMed:10910365, PubMed:10802669, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:30612738, PubMed:30886146). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Indicus|evm.model.CM009505.1.90 Q4R8C7 AIDA_MACFA 97.872 0.704545 0.48 AIDA - Axin interactor, dorsalization-associated protein - Macaca fascicularis (Crab-eating macaque) - AIDA gene Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). Indicus|evm.model.CM009505.1.91 Q4R8C7 AIDA_MACFA 98.582 0.985915 0.516364 AIDA - Axin interactor, dorsalization-associated protein - Macaca fascicularis (Crab-eating macaque) - AIDA gene Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). Indicus|evm.model.CM009505.1.92 Q7Z4H8 PLGT3_HUMAN 91.189 0.956778 1.00394 POGLUT3 - Protein O-glucosyltransferase 3 precursor - Homo sapiens (Human) - POGLUT3 gene Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1 and NOTCH3 (PubMed:30127001). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001). Indicus|evm.model.CM009505.1.93 Q8NEV8 EXPH5_HUMAN 66.599 0.990331 0.987934 EXPH5 - Exophilin-5 - Homo sapiens (Human) - EXPH5 gene May act as Rab effector protein and play a role in vesicle trafficking. Indicus|evm.model.CM009505.1.94 Q13206 DDX10_HUMAN 85.666 0.997628 0.963429 DDX10 - Probable ATP-dependent RNA helicase DDX10 - Homo sapiens (Human) - DDX10 gene Putative ATP-dependent RNA helicase. Indicus|evm.model.CM009505.1.95 Q9BGX9 CK087_MACFA 81.500 0.98995 1.01015 QflA-11381 - Uncharacterized protein C11orf87 homolog precursor - Macaca fascicularis (Crab-eating macaque) - QflA-11381 gene Indicus|evm.model.CM009505.1.97 Q28521 ROA1_MACMU 87.273 0.939655 0.3625 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Macaca mulatta (Rhesus macaque) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins (By similarity). Indicus|evm.model.CM009505.1.98 Q90835 EF1A_CHICK 61.290 0.968 0.270563 EEF1A - Elongation factor 1-alpha 1 - Gallus gallus (Chicken) - EEF1A gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Indicus|evm.model.CM009505.1.100 Q9C0D7 ZC12C_HUMAN 92.145 0.997655 0.966025 ZC3H12C - Probable ribonuclease ZC3H12C - Homo sapiens (Human) - ZC3H12C gene May function as RNase and regulate the levels of target RNA species. Indicus|evm.model.CM009505.1.101 Q32LP2 RADI_BOVIN 100.000 0.996575 1.00172 RDX - Radixin - Bos taurus (Bovine) - RDX gene Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. Indicus|evm.model.CM009505.1.102 P00257 ADX_BOVIN 99.462 0.989305 1.00538 FDX1 - Adrenodoxin, mitochondrial precursor - Bos taurus (Bovine) - FDX1 gene Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage to produce pregnenolone, the precursor of most steroid hormones. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. Indicus|evm.model.CM009505.1.103 Q9P2F6 RHG20_HUMAN 85.101 0.998309 0.993283 ARHGAP20 - Rho GTPase-activating protein 20 - Homo sapiens (Human) - ARHGAP20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009505.1.104 P15880 RS2_HUMAN 98.667 0.943038 0.539249 RPS2 - 40S ribosomal protein S2 - Homo sapiens (Human) - RPS2 gene cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleoplasm, nucleus, cadherin binding, enzyme binding Indicus|evm.model.CM009505.1.105 Q8IXP5 CK053_HUMAN 75.983 0.986957 0.974576 C11orf53 - Uncharacterized protein C11orf53 - Homo sapiens (Human) - C11orf53 gene Indicus|evm.model.CM009505.1.106 A8K830 COLC2_HUMAN 68.182 0.458967 2.13636 COLCA2 - Colorectal cancer-associated protein 2 - Homo sapiens (Human) - COLCA2 gene cytoplasm Indicus|evm.model.CM009505.1.107 Q2KJA4 OBF1_BOVIN 100.000 0.992218 1.00391 POU2AF1 - POU domain class 2-associating factor 1 - Bos taurus (Bovine) - POU2AF1 gene Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator. Indicus|evm.model.CM009505.1.109 Q9NY30 BTG4_HUMAN 83.784 0.96087 1.03139 BTG4 - Protein BTG4 - Homo sapiens (Human) - BTG4 gene Shows marked antiproliferative activity, being able to induce G(1) arrest. Indicus|evm.model.CM009505.1.110 Q32P68 HOATZ_BOVIN 88.095 0.986577 0.886905 HOATZ - Cilia- and flagella-associated protein HOATZ - Bos taurus (Bovine) - HOATZ gene Required for motile ciliogenesis and flagellar genesis by mediating the maturation of the glycolytic enzyme ENO4. Indicus|evm.model.CM009505.1.111 Q6UX15 LAYN_HUMAN 80.165 0.94385 0.979058 LAYN - Layilin precursor - Homo sapiens (Human) - LAYN gene Receptor for hyaluronate. Indicus|evm.model.CM009505.1.112 Q9H0K1 SIK2_HUMAN 86.638 0.915066 1.06803 SIK2 - Serine/threonine-protein kinase SIK2 - Homo sapiens (Human) - SIK2 gene Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Indicus|evm.model.CM009505.1.113 P54613 2AAB_PIG 97.333 0.743176 1.33887 PPP2R1B - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform - Sus scrofa (Pig) - PPP2R1B gene The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Indicus|evm.model.CM009505.1.114 Q9H6U8 ALG9_HUMAN 95.902 0.977528 1.01964 ALG9 - Alpha-1,2-mannosyltransferase ALG9 - Homo sapiens (Human) - ALG9 gene Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides. Indicus|evm.model.CM009505.1.115 Q9BRP7 FDXA1_HUMAN 80.609 0.9968 1.0016 FDXACB1 - Ferredoxin-fold anticodon-binding domain-containing protein 1 - Homo sapiens (Human) - FDXACB1 gene cytoplasm, rRNA (uridine-N3-)-methyltransferase activity, rRNA base methylation Indicus|evm.model.CM009505.1.116 P02510 CRYAB_BOVIN 100.000 0.988636 1.00571 CRYAB - Alpha-crystallin B chain - Bos taurus (Bovine) - CRYAB gene May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Indicus|evm.model.CM009505.1.117 Q16082 HSPB2_HUMAN 98.352 0.989071 1.00549 HSPB2 - Heat shock protein beta-2 - Homo sapiens (Human) - HSPB2 gene May regulate the kinase DMPK. Indicus|evm.model.CM009505.1.118 Q96A22 CK052_HUMAN 63.158 0.985075 1.08943 C11orf52 - Uncharacterized protein C11orf52 - Homo sapiens (Human) - C11orf52 gene extracellular exosome Indicus|evm.model.CM009505.1.119 Q155Q3 DIXC1_HUMAN 93.363 0.969253 1 DIXDC1 - Dixin - Homo sapiens (Human) - DIXDC1 gene Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. Indicus|evm.model.CM009505.1.120 P10515 ODP2_HUMAN 89.645 0.996914 1.00155 DLAT - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor - Homo sapiens (Human) - DLAT gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Indicus|evm.model.CM009505.1.121 Q32LH3 PIHD2_BOVIN 99.683 0.993671 1.00317 PIH1D2 - PIH1 domain-containing protein 2 - Bos taurus (Bovine) - PIH1D2 gene Indicus|evm.model.CM009505.1.122 Q6ZUT1 NKAP1_HUMAN 92.808 0.963455 1.03082 NKAPD1 - Uncharacterized protein NKAPD1 - Homo sapiens (Human) - NKAPD1 gene identical protein binding Indicus|evm.model.CM009505.1.123 Q3SZ93 TIM8B_BOVIN 100.000 0.97619 1.01205 TIMM8B - Mitochondrial import inner membrane translocase subunit Tim8 B - Bos taurus (Bovine) - TIMM8B gene Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Indicus|evm.model.CM009505.1.124 Q95123 DHSD_BOVIN 100.000 0.975 1.01266 SDHD - Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor - Bos taurus (Bovine) - SDHD gene Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Indicus|evm.model.CM009505.1.125 O43313 ATMIN_HUMAN 81.935 0.608871 0.301337 ATMIN - ATM interactor - Homo sapiens (Human) - ATMIN gene Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. Indicus|evm.model.CM009505.1.126 Q9TU73 IL18_BOVIN 100.000 0.659794 1.50777 IL18 - Interleukin-18 precursor - Bos taurus (Bovine) - IL18 gene A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Indicus|evm.model.CM009505.1.127 Q8HXG8 BCDO2_MACFA 81.115 0.956597 1.03597 BCO2 - Beta,beta-carotene 9',10'-oxygenase - Macaca fascicularis (Crab-eating macaque) - BCO2 gene Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects (By similarity). Indicus|evm.model.CM009505.1.128 Q9R1Z7 PTPS_MOUSE 90.625 0.869863 1.01389 Pts - 6-pyruvoyl tetrahydrobiopterin synthase - Mus musculus (Mouse) - Pts gene Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. Indicus|evm.model.CM009505.1.129 A5D7U1 PLET1_BOVIN 100.000 0.99177 1.00413 PLET1 - Placenta-expressed transcript 1 protein precursor - Bos taurus (Bovine) - PLET1 gene Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity). Indicus|evm.model.CM009505.1.133 P31836 NCAM1_BOVIN 99.756 0.728164 1.31536 NCAM1 - Neural cell adhesion molecule 1 precursor - Bos taurus (Bovine) - NCAM1 gene This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Indicus|evm.model.CM009505.1.134 Q9H892 TTC12_HUMAN 81.740 0.991501 1.00142 TTC12 - Tetratricopeptide repeat protein 12 - Homo sapiens (Human) - TTC12 gene Cytoplasmic protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both respiratory cells and sperm flagella. Indicus|evm.model.CM009505.1.135 Q8NFD2 ANKK1_HUMAN 46.269 0.961353 0.811765 ANKK1 - Ankyrin repeat and protein kinase domain-containing protein 1 - Homo sapiens (Human) - ANKK1 gene nucleus, regulation of cell cycle process Indicus|evm.model.CM009505.1.136 P20288 DRD2_BOVIN 99.099 0.995495 1 DRD2 - D(2) dopamine receptor - Bos taurus (Bovine) - DRD2 gene Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). Indicus|evm.model.CM009505.1.137 Q9H3S3 TMPS5_HUMAN 82.609 0.914894 0.822757 TMPRSS5 - Transmembrane protease serine 5 - Homo sapiens (Human) - TMPRSS5 gene May play a role in hearing. Indicus|evm.model.CM009505.1.138 O43264 ZW10_HUMAN 91.014 0.997436 1.00128 ZW10 - Centromere/kinetochore protein zw10 homolog - Homo sapiens (Human) - ZW10 gene Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). Indicus|evm.model.CM009505.1.139 C9JDP6 CLD25_HUMAN 81.739 0.991342 1.00873 CLDN25 - Putative claudin-25 - Homo sapiens (Human) - CLDN25 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009505.1.140 Q5I043 UBP28_MOUSE 91.582 0.258741 1.08849 Usp28 - Ubiquitin carboxyl-terminal hydrolase 28 - Mus musculus (Mouse) - Usp28 gene Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBXW7) complex. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells. Indicus|evm.model.CM009505.1.141 O95264 5HT3B_HUMAN 76.147 0.995261 0.956916 HTR3B - 5-hydroxytryptamine receptor 3B precursor - Homo sapiens (Human) - HTR3B gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Indicus|evm.model.CM009505.1.142 P46098 5HT3A_HUMAN 87.041 0.952577 1.01464 HTR3A - 5-hydroxytryptamine receptor 3A precursor - Homo sapiens (Human) - HTR3A gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Indicus|evm.model.CM009505.1.143 Q05516 ZBT16_HUMAN 95.840 0.997033 1.00149 ZBTB16 - Zinc finger and BTB domain-containing protein 16 - Homo sapiens (Human) - ZBTB16 gene Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Indicus|evm.model.CM009505.1.144 Q06AV1 NNMT_PIG 55.512 0.922794 1.0303 NNMT - Nicotinamide N-methyltransferase - Sus scrofa (Pig) - NNMT gene Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds (By similarity). Indicus|evm.model.CM009505.1.145 Q06AV1 NNMT_PIG 66.176 0.489051 0.518939 NNMT - Nicotinamide N-methyltransferase - Sus scrofa (Pig) - NNMT gene Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds (By similarity). Indicus|evm.model.CM009505.1.146 Q32L37 CK071_BOVIN 100.000 0.984962 1.00758 Uncharacterized protein C11orf71 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009505.1.147 Q3MHY8 RBM7_BOVIN 100.000 0.992395 1.00382 RBM7 - RNA-binding protein 7 - Bos taurus (Bovine) - RBM7 gene RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs). Participates in several biological processes including DNA damage response (DDR) and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability. Indicus|evm.model.CM009505.1.148 A2VE52 ORN_BOVIN 100.000 0.991597 1.00422 REXO2 - Oligoribonuclease, mitochondrial precursor - Bos taurus (Bovine) - REXO2 gene 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily Indicus|evm.model.CM009505.1.149 Q99547 MPH6_HUMAN 68.750 0.984848 0.825 MPHOSPH6 - M-phase phosphoprotein 6 - Homo sapiens (Human) - MPHOSPH6 gene RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. Indicus|evm.model.CM009505.1.150 Q6UWF7 NXPE4_HUMAN 77.615 0.957672 1.04228 NXPE4 - NXPE family member 4 precursor - Homo sapiens (Human) - NXPE4 gene extracellular exosome Indicus|evm.model.CM009505.1.151 Q96DL1 NXPE2_HUMAN 76.789 0.883562 1.04472 NXPE2 - NXPE family member 2 - Homo sapiens (Human) - NXPE2 gene Indicus|evm.model.CM009505.1.157 Q9BRD0 BUD13_HUMAN 79.294 0.996933 1.05331 BUD13 - BUD13 homolog - Homo sapiens (Human) - BUD13 gene Involved in pre-mRNA splicing as component of the activated spliceosome. Indicus|evm.model.CM009505.1.158 Q2TBX0 ZPR1_BOVIN 99.782 0.995652 1.00218 ZNF259 - Zinc finger protein ZPR1 - Bos taurus (Bovine) - ZNF259 gene Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death (By similarity). Indicus|evm.model.CM009505.1.159 Q6AYL5 SF3B4_RAT 86.000 0.206681 1.12972 Sf3b4 - Splicing factor 3B subunit 4 - Rattus norvegicus (Rat) - Sf3b4 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Indicus|evm.model.CM009505.1.160 Q32PJ2 APOA4_BOVIN 99.737 0.994751 1.00263 APOA4 - Apolipoprotein A-IV precursor - Bos taurus (Bovine) - APOA4 gene May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons (By similarity). Indicus|evm.model.CM009505.1.161 P19035 APOC3_BOVIN 100.000 0.979381 1.01042 APOC3 - Apolipoprotein C-III precursor - Bos taurus (Bovine) - APOC3 gene Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners. Indicus|evm.model.CM009505.1.162 P15497 APOA1_BOVIN 94.767 0.825243 0.777358 APOA1 - Apolipoprotein A-I precursor - Bos taurus (Bovine) - APOA1 gene Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Indicus|evm.model.CM009505.1.163 P19035 APOC3_BOVIN 81.707 0.972973 0.770833 APOC3 - Apolipoprotein C-III precursor - Bos taurus (Bovine) - APOC3 gene Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners. Indicus|evm.model.CM009505.1.164 P15497 APOA1_BOVIN 100.000 0.992481 1.00377 APOA1 - Apolipoprotein A-I precursor - Bos taurus (Bovine) - APOA1 gene Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Indicus|evm.model.CM009505.1.165 Q6P4S6 SIK3_MOUSE 89.572 0.998436 0.975591 Sik3 - Serine/threonine-protein kinase SIK3 - Mus musculus (Mouse) - Sik3 gene Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor (By similarity). Required for chondrocyte hypertrophy during skeletogenesis (PubMed:22318228). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (By similarity). Prevents HDAC4 translocation to the nucleus (PubMed:22318228). Indicus|evm.model.CM009505.1.166 Q5R4G2 PA1B2_PONAB 100.000 0.991304 1.00437 PAFAH1B2 - Platelet-activating factor acetylhydrolase IB subunit alpha2 - Pongo abelii (Sumatran orangutan) - PAFAH1B2 gene Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity). Indicus|evm.model.CM009505.1.167 Q8NBJ9 SIDT2_HUMAN 95.689 0.997596 1 SIDT2 - SID1 transmembrane family member 2 precursor - Homo sapiens (Human) - SIDT2 gene Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity). Indicus|evm.model.CM009505.1.168 Q9TS87 TAGL_BOVIN 100.000 0.990099 1.00498 TAGLN - Transgelin - Bos taurus (Bovine) - TAGLN gene Actin cross-linking/gelling protein. Indicus|evm.model.CM009505.1.169 Q16549 PCSK7_HUMAN 89.454 0.997459 1.00255 PCSK7 - Proprotein convertase subtilisin/kexin type 7 precursor - Homo sapiens (Human) - PCSK7 gene Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway. Indicus|evm.model.CM009505.1.171 Q8ND24 RN214_HUMAN 94.460 0.936085 1.06828 RNF214 - RING finger protein 214 - Homo sapiens (Human) - RNF214 gene ubiquitin-protein transferase activity Indicus|evm.model.CM009505.1.172 Q2HJ40 BACE1_BOVIN 99.800 0.996016 1.002 BACE1 - Beta-secretase 1 precursor - Bos taurus (Bovine) - BACE1 gene Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). Cleaves CHL1 (By similarity). Indicus|evm.model.CM009505.1.173 Q9UPV0 CE164_HUMAN 90.826 0.053307 1.38767 CEP164 - Centrosomal protein of 164 kDa - Homo sapiens (Human) - CEP164 gene Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. Indicus|evm.model.CM009505.1.174 Q8TD84 DSCL1_HUMAN 95.031 0.961479 0.948368 DSCAML1 - Down syndrome cell adhesion molecule-like protein 1 precursor - Homo sapiens (Human) - DSCAML1 gene Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). Indicus|evm.model.CM009505.1.175 Q04645 ATNG_BOVIN 98.077 0.309091 2.84483 FXYD2 - Sodium/potassium-transporting ATPase subunit gamma - Bos taurus (Bovine) - FXYD2 gene May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. Indicus|evm.model.CM009505.1.176 Q5R893 H2B1_PONAB 92.035 0.670659 1.3254 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009505.1.177 Q9BYE2 TMPSD_HUMAN 84.116 0.967462 0.786689 TMPRSS13 - Transmembrane protease serine 13 - Homo sapiens (Human) - TMPRSS13 gene blood microparticle, integral component of membrane, serine-type endopeptidase activity Indicus|evm.model.CM009505.1.178 Q13651 I10R1_HUMAN 68.905 0.967298 1.00519 IL10RA - Interleukin-10 receptor subunit alpha precursor - Homo sapiens (Human) - IL10RA gene Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683). Indicus|evm.model.CM009505.1.179 Q9NRS4 TMPS4_HUMAN 78.333 0.823183 1.16476 TMPRSS4 - Transmembrane protease serine 4 - Homo sapiens (Human) - TMPRSS4 gene Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity). Indicus|evm.model.CM009505.1.180 Q08E08 SCN4B_BOVIN 100.000 0.991266 1.00439 SCN4B - Sodium channel subunit beta-4 precursor - Bos taurus (Bovine) - SCN4B gene Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity). Indicus|evm.model.CM009505.1.181 O60939 SCN2B_HUMAN 94.884 0.990741 1.00465 SCN2B - Sodium channel subunit beta-2 precursor - Homo sapiens (Human) - SCN2B gene Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). Indicus|evm.model.CM009505.1.182 Q86YT9 JAML_HUMAN 67.089 0.994805 0.977157 JAML - Junctional adhesion molecule-like precursor - Homo sapiens (Human) - JAML gene Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. Indicus|evm.model.CM009505.1.183 A5D7C3 MPZL3_BOVIN 99.573 0.991489 1.00427 MPZL3 - Myelin protein zero-like protein 3 precursor - Bos taurus (Bovine) - MPZL3 gene Mediates homophilic cell-cell adhesion. Indicus|evm.model.CM009505.1.184 Q5EAB0 MPZL2_BOVIN 100.000 0.990741 1.00465 MPZL2 - Myelin protein zero-like protein 2 precursor - Bos taurus (Bovine) - MPZL2 gene Mediates homophilic cell-cell adhesion. Indicus|evm.model.CM009505.1.185 Q28073 CD3E_BOVIN 100.000 0.989637 1.00521 CD3E - T-cell surface glycoprotein CD3 epsilon chain precursor - Bos taurus (Bovine) - CD3E gene Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. Indicus|evm.model.CM009505.1.186 Q28072 CD3D_BOVIN 99.405 0.988166 1.00595 CD3D - T-cell surface glycoprotein CD3 delta chain precursor - Bos taurus (Bovine) - CD3D gene Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells. Indicus|evm.model.CM009505.1.187 Q28074 CD3G_BOVIN 100.000 0.977273 1.01734 CD3G - T-cell surface glycoprotein CD3 gamma chain precursor - Bos taurus (Bovine) - CD3G gene Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. Indicus|evm.model.CM009505.1.188 A5PKG6 UBE4A_BOVIN 100.000 0.998127 1.00094 UBE4A - Ubiquitin conjugation factor E4 A - Bos taurus (Bovine) - UBE4A gene Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. Indicus|evm.model.CM009505.1.189 Q28852 ATP5L_BOVIN 99.029 0.980769 1.00971 ATP5MG - ATP synthase subunit g, mitochondrial - Bos taurus (Bovine) - ATP5MG gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Indicus|evm.model.CM009505.1.190 P0DKL9 A14EL_HUMAN 60.667 0.973684 1 ARL14EPL - ARL14 effector protein-like - Homo sapiens (Human) - ARL14EPL gene Indicus|evm.model.CM009505.1.191 Q03164 KMT2A_HUMAN 94.539 0.994015 0.968254 KMT2A - Histone-lysine N-methyltransferase 2A - Homo sapiens (Human) - KMT2A gene Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). Indicus|evm.model.CM009505.1.192 Q3SZV0 TTC36_BOVIN 99.468 0.989418 1.00532 TTC36 - Tetratricopeptide repeat protein 36 - Bos taurus (Bovine) - TTC36 gene Indicus|evm.model.CM009505.1.193 Q86YD3 TMM25_HUMAN 92.077 0.789588 1.25956 TMEM25 - Transmembrane protein 25 precursor - Homo sapiens (Human) - TMEM25 gene In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. Indicus|evm.model.CM009505.1.194 Q1LZB4 IFT46_BOVIN 100.000 0.859599 1.15947 IFT46 - Intraflagellar transport protein 46 homolog - Bos taurus (Bovine) - IFT46 gene Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). Indicus|evm.model.CM009505.1.195 P53619 COPD_BOVIN 100.000 0.74359 1.29746 ARCN1 - Coatomer subunit delta - Bos taurus (Bovine) - ARCN1 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Indicus|evm.model.CM009505.1.196 Q63312 PHLB1_RAT 92.419 0.616024 1.59206 Phldb1 - Pleckstrin homology-like domain family B member 1 - Rattus norvegicus (Rat) - Phldb1 gene basal cortex, positive regulation of basement membrane assembly involved in embryonic body morphogenesis, regulation of epithelial to mesenchymal transition, regulation of gastrulation, regulation of microtubule cytoskeleton organization Indicus|evm.model.CM009505.1.198 O43280 TREA_HUMAN 82.312 0.982425 0.975986 TREH - Trehalase precursor - Homo sapiens (Human) - TREH gene Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. Indicus|evm.model.CM009505.1.199 P19813 TREA_RABIT 80.282 0.542636 0.223183 TREH - Trehalase precursor - Oryctolagus cuniculus (Rabbit) - TREH gene Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. Indicus|evm.model.CM009505.1.200 P26196 DDX6_HUMAN 99.793 0.993802 1.00207 DDX6 - Probable ATP-dependent RNA helicase DDX6 - Homo sapiens (Human) - DDX6 gene Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). Indicus|evm.model.CM009505.1.201 Q04683 CXCR5_MOUSE 86.631 0.994667 1.00267 Cxcr5 - C-X-C chemokine receptor type 5 - Mus musculus (Mouse) - Cxcr5 gene Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. Indicus|evm.model.CM009505.1.202 Q86UU0 BCL9L_HUMAN 94.997 0.998663 0.997999 BCL9L - B-cell CLL/lymphoma 9-like protein - Homo sapiens (Human) - BCL9L gene Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). Indicus|evm.model.CM009505.1.203 Q08537 UPK2_BOVIN 100.000 0.989247 1.00541 UPK2 - Uroplakin-2 precursor - Bos taurus (Bovine) - UPK2 gene Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM. Indicus|evm.model.CM009505.1.204 Q6PIV2 FOXR1_HUMAN 81.164 0.993151 1 FOXR1 - Forkhead box protein R1 - Homo sapiens (Human) - FOXR1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific double-stranded DNA binding Indicus|evm.model.CM009505.1.205 Q86UT8 CATAC_HUMAN 89.841 0.865014 1.09337 CENATAC - Centrosomal AT-AC splicing factor - Homo sapiens (Human) - CENATAC gene Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219). Indicus|evm.model.CM009505.1.206 Q6Q311 RS25_SHEEP 100.000 0.984127 1.008 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Indicus|evm.model.CM009505.1.207 Q2TBL9 TPPC4_BOVIN 100.000 0.990909 1.00457 TRAPPC4 - Trafficking protein particle complex subunit 4 - Bos taurus (Bovine) - TRAPPC4 gene Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (By similarity). May play a role in dendrite postsynaptic membrane trafficking (By similarity). Indicus|evm.model.CM009505.1.208 O43826 G6PT1_HUMAN 95.338 0.995349 1.00233 SLC37A4 - Glucose-6-phosphate exchanger SLC37A4 - Homo sapiens (Human) - SLC37A4 gene Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels. Indicus|evm.model.CM009505.1.210 Q9Y4L1 HYOU1_HUMAN 91.517 0.998004 1.003 HYOU1 - Hypoxia up-regulated protein 1 precursor - Homo sapiens (Human) - HYOU1 gene Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. Indicus|evm.model.CM009505.1.211 Q9H270 VPS11_HUMAN 96.281 0.997838 0.982997 VPS11 - Vacuolar protein sorting-associated protein 11 homolog - Homo sapiens (Human) - VPS11 gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995). Indicus|evm.model.CM009505.1.212 Q2KIN5 HEM3_BOVIN 100.000 0.994475 1.00277 HMBS - Porphobilinogen deaminase - Bos taurus (Bovine) - HMBS gene Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Indicus|evm.model.CM009505.1.213 P16104 H2AX_HUMAN 99.301 0.986111 1.00699 H2AX - Histone H2AX - Homo sapiens (Human) - H2AX gene Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Indicus|evm.model.CM009505.1.214 Q5EA65 GPT_BOVIN 100.000 0.99511 1.00245 DPAGT1 - UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase - Bos taurus (Bovine) - DPAGT1 gene Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol. Indicus|evm.model.CM009505.1.215 O14523 C2C2L_HUMAN 92.645 0.997175 1.00283 C2CD2L - Phospholipid transfer protein C2CD2L - Homo sapiens (Human) - C2CD2L gene Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). Indicus|evm.model.CM009505.1.216 Q2TBP2 HINFP_BOVIN 99.806 0.996132 1.00194 HINFP - Histone H4 transcription factor - Bos taurus (Bovine) - HINFP gene Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter (By similarity). Indicus|evm.model.CM009505.1.217 Q9H172 ABCG4_HUMAN 89.009 0.996909 1.00155 ABCG4 - ATP-binding cassette sub-family G member 4 - Homo sapiens (Human) - ABCG4 gene May be involved in macrophage lipid homeostasis. Indicus|evm.model.CM009505.1.218 Q86UT6 NLRX1_HUMAN 91.385 0.997947 0.998974 NLRX1 - NLR family member X1 precursor - Homo sapiens (Human) - NLRX1 gene Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Indicus|evm.model.CM009505.1.219 Q86UT5 NHRF4_HUMAN 82.303 0.924901 0.886165 PDZD3 - Na(+)/H(+) exchange regulatory cofactor NHE-RF4 - Homo sapiens (Human) - PDZD3 gene Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). Indicus|evm.model.CM009505.1.220 Q0P5D1 CC153_BOVIN 98.256 0.777273 1.07843 CCDC153 - Coiled-coil domain-containing protein 153 - Bos taurus (Bovine) - CCDC153 gene Indicus|evm.model.CM009505.1.221 P23092 CBL_MLVCN 98.182 0.370913 2.27436 V-CBL - Transforming protein cbl - Cas-NS-1 murine leukemia virus - V-CBL gene Induces early B-lineage lymphomas. Indicus|evm.model.CM009505.1.222 P43121 MUC18_HUMAN 80.805 0.996865 0.987616 MCAM - Cell surface glycoprotein MUC18 precursor - Homo sapiens (Human) - MCAM gene Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. Indicus|evm.model.CM009505.1.223 Q9BY78 RNF26_HUMAN 90.993 0.995392 1.00231 RNF26 - E3 ubiquitin-protein ligase RNF26 - Homo sapiens (Human) - RNF26 gene E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102). Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 (PubMed:27368102). Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379). Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379). Indicus|evm.model.CM009505.1.224 Q9BXJ0 C1QT5_HUMAN 97.119 0.991803 1.00412 C1QTNF5 - Complement C1q tumor necrosis factor-related protein 5 precursor - Homo sapiens (Human) - C1QTNF5 gene cell projection, extracellular space, plasma membrane Indicus|evm.model.CM009505.1.225 Q9BY79 MFRP_HUMAN 83.305 0.996546 1 MFRP - Membrane frizzled-related protein - Homo sapiens (Human) - MFRP gene May play a role in eye development. Indicus|evm.model.CM009505.1.226 Q2KHV7 UBP2_BOVIN 100.000 0.996705 1.00165 USP2 - Ubiquitin carboxyl-terminal hydrolase 2 - Bos taurus (Bovine) - USP2 gene Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1. Indicus|evm.model.CM009505.1.227 O62643 THY1_MACMU 73.913 0.987654 1.00621 THY1 - Thy-1 membrane glycoprotein precursor - Macaca mulatta (Rhesus macaque) - THY1 gene May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. Indicus|evm.model.CM009505.1.229 Q9GL76 NECT1_PIG 96.107 0.934741 1.01165 NECTIN1 - Nectin-1 precursor - Sus scrofa (Pig) - NECTIN1 gene Probably involved in cell adhesion. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. Indicus|evm.model.CM009505.1.230 Q14134 TRI29_HUMAN 88.265 0.996581 0.994898 TRIM29 - Tripartite motif-containing protein 29 - Homo sapiens (Human) - TRIM29 gene Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. Indicus|evm.model.CM009505.1.232 Q86UD1 OAF_HUMAN 90.991 0.884 0.915751 OAF - Out at first protein homolog precursor - Homo sapiens (Human) - OAF gene Indicus|evm.model.CM009505.1.233 Q9UKI9 PO2F3_HUMAN 93.632 0.995215 0.958716 POU2F3 - POU domain, class 2, transcription factor 3 - Homo sapiens (Human) - POU2F3 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen. Indicus|evm.model.CM009505.1.234 Q0VD42 TLCD5_BOVIN 99.592 0.99187 1.00408 TLCD5 - TLC domain-containing protein 5 - Bos taurus (Bovine) - TLCD5 gene Indicus|evm.model.CM009505.1.236 Q5IS46 GRIK4_PANTR 100.000 0.443396 0.110879 GRIK4 - Glutamate receptor ionotropic, kainate 4 precursor - Pan troglodytes (Chimpanzee) - GRIK4 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Indicus|evm.model.CM009505.1.237 Q8BMF5 GRIK4_MOUSE 96.262 0.736111 0.150628 Grik4 - Glutamate receptor ionotropic, kainate 4 precursor - Mus musculus (Mouse) - Grik4 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA (By similarity). Indicus|evm.model.CM009505.1.238 Q5IS46 GRIK4_PANTR 97.460 0.581481 0.564854 GRIK4 - Glutamate receptor ionotropic, kainate 4 precursor - Pan troglodytes (Chimpanzee) - GRIK4 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Indicus|evm.model.CM009505.1.239 Q5IS46 GRIK4_PANTR 99.286 0.460265 0.3159 GRIK4 - Glutamate receptor ionotropic, kainate 4 precursor - Pan troglodytes (Chimpanzee) - GRIK4 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Indicus|evm.model.CM009505.1.240 P62890 RL30_RAT 95.652 0.982759 1.0087 Rpl30 - 60S ribosomal protein L30 - Rattus norvegicus (Rat) - Rpl30 gene cytosol, cytosolic large ribosomal subunit, nucleus, polysomal ribosome, postsynaptic density, ribosome, RNA binding, selenocysteine insertion sequence binding, structural constituent of ribosome, antimicrobial humoral immune response mediated by antimicrobial peptide Indicus|evm.model.CM009505.1.241 Q3T0W7 ATG12_BOVIN 87.000 0.97 0.714286 ATG12 - Ubiquitin-like protein ATG12 - Bos taurus (Bovine) - ATG12 gene Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus (By similarity). Indicus|evm.model.CM009505.1.242 Q5QJ74 TBCEL_HUMAN 99.292 0.995294 1.00236 TBCEL - Tubulin-specific chaperone cofactor E-like protein - Homo sapiens (Human) - TBCEL gene Acts as a regulator of tubulin stability. Indicus|evm.model.CM009505.1.243 O08523 TECTA_MOUSE 95.545 0.99907 0.998144 Tecta - Alpha-tectorin precursor - Mus musculus (Mouse) - Tecta gene One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Indicus|evm.model.CM009505.1.244 O75845 SC5D_HUMAN 84.615 0.993333 1.00334 SC5D - Lathosterol oxidase - Homo sapiens (Human) - SC5D gene Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol in cholesterol biosynthesis. Indicus|evm.model.CM009505.1.245 Q92673 SORL_HUMAN 91.204 0.989292 0.97019 SORL1 - Sortilin-related receptor precursor - Homo sapiens (Human) - SORL1 gene Sorting receptor that directs several proteins to their correct location within the cell (Probable). Along with AP-1 complex, involved Golgi apparatus - endosome sorting (PubMed:17646382). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (PubMed:16174740, PubMed:16407538, PubMed:17855360, PubMed:24523320). May also sort newly produced amyloid-beta peptides to lysosomes for catabolism (PubMed:24523320). Does not affect APP trafficking from the endoplasmic reticulum to Golgi compartments (PubMed:17855360). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor (PubMed:23977241). Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion (PubMed:21994944). Sorting receptor for the GDNF-GFRA1 complex, directing it from the cell surface to endosomes. GDNF is then targeted to lysosomes and degraded, while its receptor GFRA1 recycles back to the cell membrane, resulting in a GDNF clearance pathway. The SORL1-GFRA1 complex further targets RET for endocytosis, but not for degradation, affecting GDNF-induced neurotrophic activities (PubMed:23333276). Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling. In ERBB2-dependent cancer cells, promotes cell proliferation (PubMed:31138794). Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL (PubMed:21385844). Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network (PubMed:18603531). Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue. Does not affect INSR internalization (PubMed:27322061). Plays a role in renal ion homeostasis, controlling the phospho-regulation of SLC12A1/NKCC2 by STK39/SPAK kinase and PPP3CB/calcineurin A beta phosphatase, possibly through intracellular sorting of STK39 and PPP3CB (By similarity). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR. This may promote extracellular matrix proteolysis and hence facilitate cell migration (PubMed:14764453). By acting on the migration of intimal smooth muscle cells, may accelerate intimal thickening following vascular injury (PubMed:14764453). Promotes adhesion of monocytes (PubMed:23486467). Stimulates proliferation and migration of monocytes/macrophages (By similarity). Through its action on intimal smooth muscle cells and macrophages, may accelerate intimal thickening and macrophage foam cell formation in the process of atherosclerosis (By similarity). Regulates hypoxia-enhanced adhesion of hematopoietic stem and progenitor cells to the bone marrow stromal cells via a PLAUR-mediated pathway. This function is mediated by the N-terminal ectodomain (PubMed:23486467). Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet. The N-terminal ectodomain negatively regulates adipose tissue energy expenditure, acting through the inhibition the BMP/Smad pathway (By similarity). May regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation (PubMed:26858303). May regulate IL6 signaling, decreasing cis signaling, possibly by interfering with IL6-binding to membrane-bound IL6R, while up-regulating trans signaling via soluble IL6R (PubMed:28265003). Indicus|evm.model.CM009505.1.247 Q8TF42 UBS3B_HUMAN 63.810 0.613497 0.251156 UBASH3B - Ubiquitin-associated and SH3 domain-containing protein B - Homo sapiens (Human) - UBASH3B gene Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. Indicus|evm.model.CM009505.1.249 Q8TF42 UBS3B_HUMAN 97.747 0.9216 0.96302 UBASH3B - Ubiquitin-associated and SH3 domain-containing protein B - Homo sapiens (Human) - UBASH3B gene Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. Indicus|evm.model.CM009505.1.250 O95727 CRTAM_HUMAN 75.573 0.994885 0.994911 CRTAM - Cytotoxic and regulatory T-cell molecule precursor - Homo sapiens (Human) - CRTAM gene Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Indicus|evm.model.CM009505.1.251 Q2T9M9 JHY_BOVIN 80.332 0.978903 0.919793 JHY - Jhy protein homolog - Bos taurus (Bovine) - JHY gene Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. Indicus|evm.model.CM009505.1.252 Q3C1V8 BSH_HUMAN 94.850 0.991416 1 BSX - Brain-specific homeobox protein homolog - Homo sapiens (Human) - BSX gene DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance (By similarity). Indicus|evm.model.CM009505.1.253 Q4R7Y2 RL10_MACFA 67.669 0.666667 0.813084 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009505.1.254 P19120 HSP7C_BOVIN 100.000 0.983333 1.01538 HSPA8 - Heat shock cognate 71 kDa protein - Bos taurus (Bovine) - HSPA8 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Interacts with VGF-derived peptide TLQP-21. Indicus|evm.model.CM009505.1.255 Q9H6B4 CLMP_HUMAN 90.385 0.970588 1.00268 CLMP - CXADR-like membrane protein precursor - Homo sapiens (Human) - CLMP gene May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development. Indicus|evm.model.CM009505.1.256 Q3KR37 ASTRB_HUMAN 97.808 0.826682 1.18835 GRAMD1B - Protein Aster-B - Homo sapiens (Human) - GRAMD1B gene Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). Indicus|evm.model.CM009505.1.257 Q2KI11 SCN3B_BOVIN 99.535 0.990741 1.00465 SCN3B - Sodium channel subunit beta-3 precursor - Bos taurus (Bovine) - SCN3B gene Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). Indicus|evm.model.CM009505.1.258 O95125 ZN202_HUMAN 87.963 0.996918 1.00154 ZNF202 - Zinc finger protein 202 - Homo sapiens (Human) - ZNF202 gene Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease. Indicus|evm.model.CM009505.1.259 P0DSO0 SAA2_PIG 59.302 0.901099 0.705426 SAA2 - Serum amyloid A-2 protein precursor - Sus scrofa (Pig) - SAA2 gene Major acute phase reactant. Indicus|evm.model.CM009505.1.260 Q96ER3 SAAL1_HUMAN 90.717 0.995781 1 SAAL1 - Protein SAAL1 - Homo sapiens (Human) - SAAL1 gene Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli. Indicus|evm.model.CM009505.1.261 P17752 TPH1_HUMAN 96.396 0.942553 1.05856 TPH1 - Tryptophan 5-hydroxylase 1 - Homo sapiens (Human) - TPH1 gene Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. Indicus|evm.model.CM009505.1.263 P25122 KCNC1_RAT 99.829 0.996587 1.00171 Kcnc1 - Potassium voltage-gated channel subfamily C member 1 - Rattus norvegicus (Rat) - Kcnc1 gene Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10482766, PubMed:14679187). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well (PubMed:10482766, PubMed:14679187). Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (PubMed:10482766). Indicus|evm.model.CM009505.1.264 Q7YS82 MYOD1_BOVIN 99.686 0.99373 1.00314 MYOD1 - Myoblast determination protein 1 - Bos taurus (Bovine) - MYOD1 gene Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). Indicus|evm.model.CM009505.1.265 Q6ZRI0 OTOG_HUMAN 85.450 0.986106 1.00889 OTOG - Otogelin precursor - Homo sapiens (Human) - OTOG gene Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity). Indicus|evm.model.CM009505.1.266 Q3MHQ0 USH1C_BOVIN 99.533 0.458155 1.69147 USH1C - Harmonin - Bos taurus (Bovine) - USH1C gene Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (By similarity). Indicus|evm.model.CM009505.1.267 Q09428 ABCC8_HUMAN 96.275 0.998738 1.00253 ABCC8 - ATP-binding cassette sub-family C member 8 - Homo sapiens (Human) - ABCC8 gene Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. Indicus|evm.model.CM009505.1.268 O02822 KCJ11_RABIT 95.897 0.994859 0.997436 KCNJ11 - ATP-sensitive inward rectifier potassium channel 11 - Oryctolagus cuniculus (Rabbit) - KCNJ11 gene This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity). Indicus|evm.model.CM009505.1.269 Q68D85 NR3L1_HUMAN 53.668 0.627792 0.887665 NCR3LG1 - Natural cytotoxicity triggering receptor 3 ligand 1 precursor - Homo sapiens (Human) - NCR3LG1 gene Triggers NCR3-dependent natural killer cell activation. Indicus|evm.model.CM009505.1.270 P80303 NUCB2_HUMAN 91.106 0.995192 0.990476 NUCB2 - Nucleobindin-2 precursor - Homo sapiens (Human) - NUCB2 gene Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). Indicus|evm.model.CM009505.1.272 P55263 ADK_HUMAN 92.143 0.626126 0.61326 ADK - Adenosine kinase - Homo sapiens (Human) - ADK gene ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. Indicus|evm.model.CM009505.1.273 O00443 P3C2A_HUMAN 89.696 0.920895 1.08719 PIK3C2A - Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha - Homo sapiens (Human) - PIK3C2A gene Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). Indicus|evm.model.CM009505.1.275 Q6IQ23 PKHA7_HUMAN 92.447 0.833333 1.11329 PLEKHA7 - Pleckstrin homology domain-containing family A member 7 - Homo sapiens (Human) - PLEKHA7 gene Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). Indicus|evm.model.CM009505.1.276 Q3MHL8 SMAP_BOVIN 100.000 0.989011 1.00552 SMAP - Small acidic protein - Bos taurus (Bovine) - SMAP gene Indicus|evm.model.CM009505.1.277 Q5RCU4 SOX6_PONAB 98.337 0.997921 0.611182 SOX6 - Transcription factor SOX-6 - Pongo abelii (Sumatran orangutan) - SOX6 gene Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor. Indicus|evm.model.CM009505.1.280 Q1MX18 INSC_HUMAN 90.196 0.995736 0.810017 INSC - Protein inscuteable homolog - Homo sapiens (Human) - INSC gene May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity). Indicus|evm.model.CM009505.1.281 P01261 CALC_SHEEP 95.105 0.986111 1.00699 CALCA - Calcitonin precursor - Ovis aries (Sheep) - CALCA gene Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Indicus|evm.model.CM009505.1.282 Q9N0V5 CALC_HORSE 61.475 0.96748 0.878571 CALCA - Calcitonin precursor - Equus caballus (Horse) - CALCA gene Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Indicus|evm.model.CM009505.1.283 Q75V95 CRSP1_BOVIN 100.000 0.420455 1.408 CRSP1 - Calcitonin receptor-stimulating peptide 1 precursor - Bos taurus (Bovine) - CRSP1 gene Stimulates cAMP production in porcine kidney cell line LLC-PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. Indicus|evm.model.CM009505.1.284 Q96AX1 VP33A_HUMAN 95.146 0.728571 0.234899 VPS33A - Vacuolar protein sorting-associated protein 33A - Homo sapiens (Human) - VPS33A gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770). Indicus|evm.model.CM009505.1.285 B3IWF8 CRSP2_CAPHI 58.772 0.554455 1.616 CRSP2 - Calcitonin receptor-stimulating peptide 2 precursor - Capra hircus (Goat) - CRSP2 gene Indicus|evm.model.CM009505.1.286 Q6VVX0 CP2R1_HUMAN 93.895 0.944223 1.002 CYP2R1 - Vitamin D 25-hydroxylase precursor - Homo sapiens (Human) - CYP2R1 gene A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol) (PubMed:12867411, PubMed:15465040, PubMed:18511070). Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives (PubMed:15465040, PubMed:18511070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:12867411, PubMed:15465040, PubMed:18511070). Indicus|evm.model.CM009505.1.287 Q13370 PDE3B_HUMAN 85.344 0.993728 1.0036 PDE3B - cGMP-inhibited 3',5'-cyclic phosphodiesterase B - Homo sapiens (Human) - PDE3B gene Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. Indicus|evm.model.CM009505.1.288 Q3T0X5 PSA1_BOVIN 100.000 0.992424 1.0038 PSMA1 - Proteasome subunit alpha type-1 - Bos taurus (Bovine) - PSMA1 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Indicus|evm.model.CM009505.1.289 A0JN39 COPB_BOVIN 100.000 0.997904 1.00105 COPB1 - Coatomer subunit beta - Bos taurus (Bovine) - COPB1 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Involved in the Golgi disassembly and reassembly processes during cell cycle. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Indicus|evm.model.CM009505.1.290 O46414 FRIH_BOVIN 97.790 0.989011 1.00552 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009505.1.291 P62071 RRAS2_MOUSE 99.408 0.888889 0.926471 Rras2 - Ras-related protein R-Ras2 precursor - Mus musculus (Mouse) - Rras2 gene GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes. Involved in the regulation of MAPK signaling pathway. Regulation of craniofacial development. Indicus|evm.model.CM009505.1.292 Q9GLX9 SPON1_BOVIN 99.876 0.997525 1.00124 SPON1 - Spondin-1 precursor - Bos taurus (Bovine) - SPON1 gene Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell. Indicus|evm.model.CM009505.1.294 Q5R834 FACR1_PONAB 98.447 0.926126 1.07767 FAR1 - Fatty acyl-CoA reductase 1 - Pongo abelii (Sumatran orangutan) - FAR1 gene Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis. Indicus|evm.model.CM009505.1.296 P01268 PTHY_BOVIN 99.048 0.981132 0.921739 PTH - Parathyroid hormone precursor - Bos taurus (Bovine) - PTH gene PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). Indicus|evm.model.CM009505.1.297 Q80X66 BTBDA_MOUSE 97.895 0.995798 1.00211 Btbd10 - BTB/POZ domain-containing protein 10 - Mus musculus (Mouse) - Btbd10 gene Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. Indicus|evm.model.CM009505.1.298 A0MLS5 BMAL1_HORSE 98.722 0.99681 1.0016 ARNTL - Aryl hydrocarbon receptor nuclear translocator-like protein 1 - Equus caballus (Horse) - ARNTL gene Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence. CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3'. The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3'. Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1. Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). Indicus|evm.model.CM009505.1.299 A6NK89 RASFA_HUMAN 86.693 0.996094 1.00986 RASSF10 - Ras association domain-containing protein 10 - Homo sapiens (Human) - RASSF10 gene Plays an important role in regulating embryonic neurogenesis. Indicus|evm.model.CM009505.1.300 P28347 TEAD1_HUMAN 95.078 0.691473 1.51408 TEAD1 - Transcriptional enhancer factor TEF-1 - Homo sapiens (Human) - TEAD1 gene Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. Indicus|evm.model.CM009505.1.301 Q9NVD7 PARVA_HUMAN 88.079 0.860841 0.830645 PARVA - Alpha-parvin - Homo sapiens (Human) - PARVA gene Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Indicus|evm.model.CM009505.1.302 Q9Y6A5 TACC3_HUMAN 69.128 0.717073 0.24463 TACC3 - Transforming acidic coiled-coil-containing protein 3 - Homo sapiens (Human) - TACC3 gene Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). Indicus|evm.model.CM009505.1.303 Q9HB97 PARVA_RAT 100.000 0.637681 0.185484 Parva - Alpha-parvin - Rattus norvegicus (Rat) - Parva gene Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Indicus|evm.model.CM009505.1.304 Q6ZW33 MICLK_HUMAN 67.489 0.778416 1.25324 MICALCL - MICAL C-terminal-like protein - Homo sapiens (Human) - MICALCL gene May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. May act as Rab effector protein and play a role in vesicle trafficking. Indicus|evm.model.CM009505.1.305 F1MF74 MICA2_BOVIN 99.818 0.998185 1.00091 MICAL2 - [F-actin]-monooxygenase MICAL2 - Bos taurus (Bovine) - MICAL2 gene Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (By similarity). Indicus|evm.model.CM009505.1.307 Q9UBP4 DKK3_HUMAN 88.088 0.905714 1 DKK3 - Dickkopf-related protein 3 precursor - Homo sapiens (Human) - DKK3 gene Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). Indicus|evm.model.CM009505.1.308 Q96K76 UBP47_HUMAN 95.927 0.998525 0.986182 USP47 - Ubiquitin carboxyl-terminal hydrolase 47 - Homo sapiens (Human) - USP47 gene Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. Indicus|evm.model.CM009505.1.309 Q6P9A2 GLT18_HUMAN 98.353 0.996711 1.00165 GALNT18 - Polypeptide N-acetylgalactosaminyltransferase 18 - Homo sapiens (Human) - GALNT18 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Indicus|evm.model.CM009505.1.310 Q148I0 L10K_BOVIN 97.959 0.979798 1.0102 Leydig cell tumor 10 kDa protein homolog - Bos taurus (Bovine) Indicus|evm.model.CM009505.1.311 A4Z943 ZBED5_BOVIN 99.712 0.997122 1.00144 ZBED5 - Zinc finger BED domain-containing protein 5 - Bos taurus (Bovine) - ZBED5 gene Indicus|evm.model.CM009505.1.312 Q5R7J9 IF4G2_PONAB 99.890 0.813285 1.22822 EIF4G2 - Eukaryotic translation initiation factor 4 gamma 2 - Pongo abelii (Sumatran orangutan) - EIF4G2 gene Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity). Indicus|evm.model.CM009505.1.313 Q6PD62 CTR9_HUMAN 91.731 0.998206 0.950554 CTR9 - RNA polymerase-associated protein CTR9 homolog - Homo sapiens (Human) - CTR9 gene Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). Indicus|evm.model.CM009505.1.314 A4FUB7 GIN1_BOVIN 92.514 0.996169 1.04609 GIN1 - Gypsy retrotransposon integrase-like protein 1 - Bos taurus (Bovine) - GIN1 gene Indicus|evm.model.CM009505.1.315 Q9N1F0 IRAG1_BOVIN 99.663 0.983389 0.991218 IRAG1 - Inositol 1,4,5-triphosphate receptor associated 1 - Bos taurus (Bovine) - IRAG1 gene Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. Indicus|evm.model.CM009505.1.316 Q6UC88 LYVE1_BOVIN 99.379 0.993808 1.00311 LYVE1 - Lymphatic vessel endothelial hyaluronic acid receptor 1 precursor - Bos taurus (Bovine) - LYVE1 gene Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Indicus|evm.model.CM009505.1.317 Q32L15 RN141_BOVIN 100.000 0.991342 1.00435 RNF141 - RING finger protein 141 - Bos taurus (Bovine) - RNF141 gene May be involved in spermatogenesis. Indicus|evm.model.CM009505.1.318 Q01432 AMPD3_HUMAN 89.439 0.997351 0.984355 AMPD3 - AMP deaminase 3 - Homo sapiens (Human) - AMPD3 gene AMP deaminase plays a critical role in energy metabolism. Indicus|evm.model.CM009505.1.319 O62827 ADML_BOVIN 100.000 0.989418 1.00532 ADM - Pro-adrenomedullin precursor - Bos taurus (Bovine) - ADM gene Hypotensive peptide. May function as a hormone in circulation control (By similarity). Indicus|evm.model.CM009505.1.320 Q86WG5 MTMRD_HUMAN 97.258 0.998387 0.335316 SBF2 - Myotubularin-related protein 13 - Homo sapiens (Human) - SBF2 gene Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity). Indicus|evm.model.CM009505.1.321 P0C1G6 SWP70_BOVIN 99.829 0.996587 1.00171 SWAP70 - Switch-associated protein 70 - Bos taurus (Bovine) - SWAP70 gene Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). Indicus|evm.model.CM009505.1.322 Q9NX08 COMD8_HUMAN 79.518 0.982143 0.918033 COMMD8 - COMM domain-containing protein 8 - Homo sapiens (Human) - COMMD8 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Indicus|evm.model.CM009505.1.323 P30291 WEE1_HUMAN 96.795 0.990461 0.973684 WEE1 - Wee1-like protein kinase - Homo sapiens (Human) - WEE1 gene Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Indicus|evm.model.CM009505.1.324 A6QQW0 ZN143_BOVIN 93.238 0.553535 0.807504 ZNF143 - Zinc finger protein 143 - Bos taurus (Bovine) - ZNF143 gene Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity). Indicus|evm.model.CM009505.1.325 O95373 IPO7_HUMAN 99.904 0.998075 1.00096 IPO7 - Importin-7 - Homo sapiens (Human) - IPO7 gene Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Indicus|evm.model.CM009505.1.326 P62752 RL23A_RAT 70.526 0.647887 0.910256 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009505.1.327 Q5FVN2 TM41B_RAT 92.440 0.993151 1.00344 Tmem41b - Transmembrane protein 41B - Rattus norvegicus (Rat) - Tmem41b gene Required for autophagosome formation (By similarity). Participates in early stages of autophagosome biogenesis at the ER membrane proabably via mobilization of neutral lipids from lipid droplets (By similarity). Required for normal motor neuron development (By similarity). Essential for embryonic development (By similarity). Indicus|evm.model.CM009505.1.328 Q1LZG6 CCNB1_BOVIN 81.266 0.983193 0.836066 CCNB1 - G2/mitotic-specific cyclin-B1 - Bos taurus (Bovine) - CCNB1 gene Essential for the control of the cell cycle at the G2/M (mitosis) transition. Indicus|evm.model.CM009505.1.329 Q6IQ26 DEN5A_HUMAN 97.883 0.983173 0.969697 DENND5A - DENN domain-containing protein 5A - Homo sapiens (Human) - DENND5A gene Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). Indicus|evm.model.CM009505.1.330 Q9NQ36 SCUB2_HUMAN 89.202 0.998054 1.02903 SCUBE2 - Signal peptide, CUB and EGF-like domain-containing protein 2 precursor - Homo sapiens (Human) - SCUBE2 gene Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687). Indicus|evm.model.CM009505.1.331 Q9NQ35 NRIP3_HUMAN 94.561 0.940476 1.04564 NRIP3 - Nuclear receptor-interacting protein 3 - Homo sapiens (Human) - NRIP3 gene Indicus|evm.model.CM009505.1.332 Q9NQ34 TMM9B_HUMAN 97.006 0.677551 1.23737 TMEM9B - Transmembrane protein 9B precursor - Homo sapiens (Human) - TMEM9B gene Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways. Indicus|evm.model.CM009505.1.333 Q17QV3 SUMO3_BOVIN 98.077 0.980952 1.00962 SUMO3 - Small ubiquitin-related modifier 3 precursor - Bos taurus (Bovine) - SUMO3 gene Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity). Indicus|evm.model.CM009505.1.334 Q9NQ33 ASCL3_HUMAN 81.111 0.983516 1.01111 ASCL3 - Achaete-scute homolog 3 - Homo sapiens (Human) - ASCL3 gene Transcriptional repressor. Inhibits myogenesis (By similarity). Indicus|evm.model.CM009505.1.335 Q9NQ32 CK016_HUMAN 67.304 0.975104 1.03212 C11orf16 - Uncharacterized protein C11orf16 - Homo sapiens (Human) - C11orf16 gene Indicus|evm.model.CM009505.1.336 Q9NQ31 AKIP1_HUMAN 73.810 0.990385 0.990476 AKIP1 - A-kinase-interacting protein 1 - Homo sapiens (Human) - AKIP1 gene Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Indicus|evm.model.CM009505.1.337 P78524 DEN2B_HUMAN 93.931 0.981002 1.01847 DENND2B - DENN domain-containing protein 2B - Homo sapiens (Human) - DENND2B gene May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). Indicus|evm.model.CM009505.1.338 Q56K03 RL27A_BOVIN 100.000 0.986577 1.00676 RPL27A - 60S ribosomal protein L27a - Bos taurus (Bovine) - RPL27A gene cytosolic large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009505.1.339 Q924W6 TRI66_MOUSE 85.497 0.998396 1.00403 Trim66 - Tripartite motif-containing protein 66 - Mus musculus (Mouse) - Trim66 gene May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association. Indicus|evm.model.CM009505.1.340 Q0VD22 STK33_BOVIN 98.901 0.876448 1.06584 STK33 - Serine/threonine-protein kinase 33 - Bos taurus (Bovine) - STK33 gene Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Indicus|evm.model.CM009505.1.341 Q0P5B3 RBTN1_BOVIN 100.000 0.987261 1.00641 LMO1 - Rhombotin-1 - Bos taurus (Bovine) - LMO1 gene May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Indicus|evm.model.CM009505.1.342 Q7Z5B4 RIC3_HUMAN 86.450 0.994565 0.99729 RIC3 - Protein RIC-3 precursor - Homo sapiens (Human) - RIC3 gene Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors (PubMed:12821669, PubMed:15504725, PubMed:16120769, PubMed:18691158, PubMed:32204458). May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. Indicus|evm.model.CM009505.1.343 P50607 TUB_HUMAN 93.137 0.996071 1.00593 TUB - Tubby protein homolog - Homo sapiens (Human) - TUB gene Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. Indicus|evm.model.CM009505.1.344 Q9DCH4 EIF3F_MOUSE 98.566 0.710997 1.0831 Eif3f - Eukaryotic translation initiation factor 3 subunit F - Mus musculus (Mouse) - Eif3f gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Indicus|evm.model.CM009505.1.347 Q8NGY1 O10Z1_HUMAN 56.962 0.877095 0.571885 OR10Z1 - Olfactory receptor 10Z1 - Homo sapiens (Human) - OR10Z1 gene Odorant receptor. Indicus|evm.model.CM009505.1.348 Q6BCY4 NB5R2_HUMAN 80.000 0.311718 3.18478 CYB5R2 - NADH-cytochrome b5 reductase 2 - Homo sapiens (Human) - CYB5R2 gene NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1). Indicus|evm.model.CM009505.1.349 Q8ND30 LIPB2_HUMAN 86.942 0.948689 1.00114 PPFIBP2 - Liprin-beta-2 - Homo sapiens (Human) - PPFIBP2 gene May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Indicus|evm.model.CM009505.1.350 Q6UWY5 OLFL1_HUMAN 84.328 0.995037 1.00249 OLFML1 - Olfactomedin-like protein 1 precursor - Homo sapiens (Human) - OLFML1 gene Indicus|evm.model.CM009505.1.352 Q86SS6 SYT9_HUMAN 98.592 0.561753 0.511202 SYT9 - Synaptotagmin-9 - Homo sapiens (Human) - SYT9 gene May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Indicus|evm.model.CM009505.1.353 Q86SS6 SYT9_HUMAN 97.126 0.865337 0.816701 SYT9 - Synaptotagmin-9 - Homo sapiens (Human) - SYT9 gene May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Indicus|evm.model.CM009505.1.354 Q29RT0 RBMX_BOVIN 100.000 0.251889 1.00253 RBMX - RNA-binding motif protein, X chromosome - Bos taurus (Bovine) - RBMX gene RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment (By similarity). Indicus|evm.model.CM009505.1.355 Q86W24 NAL14_HUMAN 70.360 0.9875 0.95151 NLRP14 - NACHT, LRR and PYD domains-containing protein 14 - Homo sapiens (Human) - NLRP14 gene May be involved in inflammation and spermatogenesis. Indicus|evm.model.CM009505.1.356 Q58DQ3 RL6_BOVIN 76.786 0.258216 0.74216 RPL6 - 60S ribosomal protein L6 - Bos taurus (Bovine) - RPL6 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009505.1.357 Q9UL59 ZN214_HUMAN 79.041 0.931894 0.993399 ZNF214 - Zinc finger protein 214 - Homo sapiens (Human) - ZNF214 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009505.1.358 Q9UL58 ZN215_HUMAN 72.538 0.996219 1.02321 ZNF215 - Zinc finger protein 215 - Homo sapiens (Human) - ZNF215 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009505.1.359 Q7Z2Y8 GVIN1_HUMAN 54.527 0.901487 0.444261 GVINP1 - Interferon-induced very large GTPase 1 - Homo sapiens (Human) - GVINP1 gene Indicus|evm.model.CM009505.1.360 Q7Z2Y8 GVIN1_HUMAN 71.642 0.99868 0.938068 GVINP1 - Interferon-induced very large GTPase 1 - Homo sapiens (Human) - GVINP1 gene Indicus|evm.model.CM009505.1.361 Q9NRX2 RM17_HUMAN 84.146 0.647541 0.697143 MRPL17 - 39S ribosomal protein L17, mitochondrial precursor - Homo sapiens (Human) - MRPL17 gene large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, protein domain specific binding, structural constituent of ribosome, mitochondrial translational elongation, mitochondrial translational termination Indicus|evm.model.CM009505.1.362 Q7Z2Y8 GVIN1_HUMAN 69.935 0.443347 0.71057 GVINP1 - Interferon-induced very large GTPase 1 - Homo sapiens (Human) - GVINP1 gene Indicus|evm.model.CM009505.1.363 Q3T0L3 RM17_BOVIN 99.419 0.988439 1.00581 MRPL17 - 39S ribosomal protein L17, mitochondrial precursor - Bos taurus (Bovine) - MRPL17 gene large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009505.1.364 Q96JQ0 PCD16_HUMAN 93.910 0.549148 1.01486 DCHS1 - Protocadherin-16 precursor - Homo sapiens (Human) - DCHS1 gene Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). Indicus|evm.model.CM009505.1.365 Q0V8B6 TPP1_BOVIN 99.161 0.722307 1.17052 TPP1 - Tripeptidyl-peptidase 1 precursor - Bos taurus (Bovine) - TPP1 gene Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). Indicus|evm.model.CM009505.1.366 Q3SWY2 ILK_BOVIN 100.000 0.995585 1.00221 ILK - Integrin-linked protein kinase - Bos taurus (Bovine) - ILK gene Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. Indicus|evm.model.CM009505.1.367 O43159 RRP8_HUMAN 78.696 0.995662 1.01096 RRP8 - Ribosomal RNA-processing protein 8 - Homo sapiens (Human) - RRP8 gene Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. Indicus|evm.model.CM009505.1.368 Q96M86 DNHD1_HUMAN 74.175 0.988438 1.00084 DNHD1 - Dynein heavy chain domain-containing protein 1 - Homo sapiens (Human) - DNHD1 gene dynein complex, extracellular exosome, inner dynein arm, ATP-dependent microtubule motor activity, minus-end-directed, dynein intermediate chain binding, dynein light intermediate chain binding, cilium movement, microtubule-based movement Indicus|evm.model.CM009505.1.369 Q3SZW4 T10B_BOVIN 97.436 0.928 1.05932 TIMM10B - Mitochondrial import inner membrane translocase subunit Tim10 B - Bos taurus (Bovine) - TIMM10B gene Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. Indicus|evm.model.CM009505.1.370 Q3ZCL5 ARFP2_BOVIN 100.000 0.994152 1.00293 ARFIP2 - Arfaptin-2 - Bos taurus (Bovine) - ARFIP2 gene Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG. Indicus|evm.model.CM009505.1.371 O75382 TRIM3_HUMAN 99.194 0.997315 1.00134 TRIM3 - Tripartite motif-containing protein 3 - Homo sapiens (Human) - TRIM3 gene Probably involved in vesicular trafficking via its association with the CART complex (PubMed:15772161). The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Indicus|evm.model.CM009505.1.372 Q3SZV7 HEMO_BOVIN 99.129 0.995652 1.00218 HPX - Hemopexin precursor - Bos taurus (Bovine) - HPX gene Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Indicus|evm.model.CM009505.1.373 O00213 APBB1_HUMAN 96.197 0.997175 0.997183 APBB1 - Amyloid-beta A4 precursor protein-binding family B member 1 - Homo sapiens (Human) - APBB1 gene Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Indicus|evm.model.CM009505.1.374 Q0VD19 ASM_BOVIN 99.520 0.996805 1.0016 SMPD1 - Sphingomyelin phosphodiesterase precursor - Bos taurus (Bovine) - SMPD1 gene Converts sphingomyelin to ceramide. Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly. However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form. Indicus|evm.model.CM009505.1.376 A4FV37 CAVN3_BOVIN 99.615 0.992337 1.00385 CAVIN3 - Caveolae-associated protein 3 - Bos taurus (Bovine) - CAVIN3 gene Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2. Indicus|evm.model.CM009505.1.377 P79266 GASR_BOVIN 99.559 0.995604 1.0022 CCKBR - Gastrin/cholecystokinin type B receptor - Bos taurus (Bovine) - CCKBR gene Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009505.1.378 Q8IV77 CNGA4_HUMAN 94.087 0.996528 1.00174 CNGA4 - Cyclic nucleotide-gated cation channel alpha-4 - Homo sapiens (Human) - CNGA4 gene Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). Indicus|evm.model.CM009505.1.379 A7YY62 F16A2_BOVIN 99.730 0.685529 1.10791 FHIP1B - FHF complex subunit HOOK interacting protein 1B - Bos taurus (Bovine) - FHIP1B gene Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. Indicus|evm.model.CM009505.1.380 Q8N5U0 CK042_HUMAN 87.087 0.994012 1.003 C11orf42 - Uncharacterized protein C11orf42 - Homo sapiens (Human) - C11orf42 gene Indicus|evm.model.CM009505.1.381 Q6IF63 O52W1_HUMAN 87.736 0.987539 1.00313 OR52W1 - Olfactory receptor 52W1 - Homo sapiens (Human) - OR52W1 gene Odorant receptor. Indicus|evm.model.CM009505.1.382 Q96RD2 O52B2_HUMAN 88.172 0.989305 0.578947 OR52B2 - Olfactory receptor 52B2 - Homo sapiens (Human) - OR52B2 gene Odorant receptor. Indicus|evm.model.CM009505.1.383 P62752 RL23A_RAT 70.833 0.94 0.320513 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009505.1.384 Q3T000 YKT6_BOVIN 78.846 0.723404 0.712121 YKT6 - Synaptobrevin homolog YKT6 precursor - Bos taurus (Bovine) - YKT6 gene Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. Indicus|evm.model.CM009505.1.385 Q8NGH7 O52L1_HUMAN 86.495 0.974843 0.966565 OR52L1 - Olfactory receptor 52L1 - Homo sapiens (Human) - OR52L1 gene Odorant receptor. Indicus|evm.model.CM009505.1.386 Q8NGH7 O52L1_HUMAN 86.068 0.952663 1.02736 OR52L1 - Olfactory receptor 52L1 - Homo sapiens (Human) - OR52L1 gene Odorant receptor. Indicus|evm.model.CM009505.1.387 Q8NGH5 O56A1_HUMAN 84.665 0.990476 0.990566 OR56A1 - Olfactory receptor 56A1 - Homo sapiens (Human) - OR56A1 gene Odorant receptor. Indicus|evm.model.CM009505.1.388 Q8NGH8 O56A4_HUMAN 93.836 0.336427 1.377 OR56A4 - Olfactory receptor 56A4 - Homo sapiens (Human) - OR56A4 gene Odorant receptor. Indicus|evm.model.CM009505.1.389 Q8NGH8 O56A4_HUMAN 91.558 0.987097 0.495208 OR56A4 - Olfactory receptor 56A4 - Homo sapiens (Human) - OR56A4 gene Odorant receptor. Indicus|evm.model.CM009505.1.390 Q8NGH8 O56A4_HUMAN 66.238 0.984127 1.00639 OR56A4 - Olfactory receptor 56A4 - Homo sapiens (Human) - OR56A4 gene Odorant receptor. Indicus|evm.model.CM009505.1.391 Q8NH54 O56A3_HUMAN 75.595 0.988024 0.530159 OR56A3 - Olfactory receptor 56A3 - Homo sapiens (Human) - OR56A3 gene Odorant receptor. Indicus|evm.model.CM009505.1.392 Q8NH54 O56A3_HUMAN 83.721 0.977099 0.415873 OR56A3 - Olfactory receptor 56A3 - Homo sapiens (Human) - OR56A3 gene Odorant receptor. Indicus|evm.model.CM009505.1.393 Q8NH54 O56A3_HUMAN 83.121 0.990506 1.00317 OR56A3 - Olfactory receptor 56A3 - Homo sapiens (Human) - OR56A3 gene Odorant receptor. Indicus|evm.model.CM009505.1.394 Q8NH54 O56A3_HUMAN 79.618 0.978125 1.01587 OR56A3 - Olfactory receptor 56A3 - Homo sapiens (Human) - OR56A3 gene Odorant receptor. Indicus|evm.model.CM009505.1.395 Q8NH54 O56A3_HUMAN 87.580 0.990506 1.00317 OR56A3 - Olfactory receptor 56A3 - Homo sapiens (Human) - OR56A3 gene Odorant receptor. Indicus|evm.model.CM009505.1.396 Q8NGH8 O56A4_HUMAN 89.137 0.993631 1.00319 OR56A4 - Olfactory receptor 56A4 - Homo sapiens (Human) - OR56A4 gene Odorant receptor. Indicus|evm.model.CM009505.1.397 Q8NGH9 O52E4_HUMAN 90.411 0.753886 1.23718 OR52E4 - Olfactory receptor 52E4 - Homo sapiens (Human) - OR52E4 gene Odorant receptor. Indicus|evm.model.CM009505.1.398 Q6IFG1 O52E8_HUMAN 84.889 0.941176 0.750789 OR52E8 - Olfactory receptor 52E8 - Homo sapiens (Human) - OR52E8 gene Odorant receptor. Indicus|evm.model.CM009505.1.399 Q6IFG1 O52E8_HUMAN 67.752 0.972881 0.930599 OR52E8 - Olfactory receptor 52E8 - Homo sapiens (Human) - OR52E8 gene Odorant receptor. Indicus|evm.model.CM009505.1.400 Q6IFG1 O52E8_HUMAN 74.194 0.98722 0.987382 OR52E8 - Olfactory receptor 52E8 - Homo sapiens (Human) - OR52E8 gene Odorant receptor. Indicus|evm.model.CM009505.1.401 Q8NGI0 O52N2_HUMAN 83.732 0.985782 0.657321 OR52N2 - Olfactory receptor 52N2 - Homo sapiens (Human) - OR52N2 gene Odorant receptor. Indicus|evm.model.CM009505.1.402 Q8NH53 O52N1_HUMAN 86.420 0.97561 0.25625 OR52N1 - Olfactory receptor 52N1 - Homo sapiens (Human) - OR52N1 gene Odorant receptor. Indicus|evm.model.CM009505.1.403 Q8NH56 O52N5_HUMAN 86.572 0.979094 0.885802 OR52N5 - Olfactory receptor 52N5 - Homo sapiens (Human) - OR52N5 gene Odorant receptor. Indicus|evm.model.CM009505.1.404 Q8NGI0 O52N2_HUMAN 87.812 0.990683 1.00312 OR52N2 - Olfactory receptor 52N2 - Homo sapiens (Human) - OR52N2 gene Odorant receptor. Indicus|evm.model.CM009505.1.405 Q8NGI0 O52N2_HUMAN 83.251 0.961905 0.654206 OR52N2 - Olfactory receptor 52N2 - Homo sapiens (Human) - OR52N2 gene Odorant receptor. Indicus|evm.model.CM009505.1.406 A4FV72 PPIE_BOVIN 98.630 0.9 0.265781 PPIE - Peptidyl-prolyl cis-trans isomerase E - Bos taurus (Bovine) - PPIE gene Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity. Indicus|evm.model.CM009505.1.407 Q8NH53 O52N1_HUMAN 86.061 0.982036 0.521875 OR52N1 - Olfactory receptor 52N1 - Homo sapiens (Human) - OR52N1 gene Odorant receptor. Indicus|evm.model.CM009505.1.408 Q8NH56 O52N5_HUMAN 89.600 0.972656 0.790123 OR52N5 - Olfactory receptor 52N5 - Homo sapiens (Human) - OR52N5 gene Odorant receptor. Indicus|evm.model.CM009505.1.409 Q8NGI1 O56B2_HUMAN 75.188 0.985075 0.416149 OR56B2P - Putative olfactory receptor 56B2 - Homo sapiens (Human) - OR56B2P gene Odorant receptor. Indicus|evm.model.CM009505.1.410 Q8NGI1 O56B2_HUMAN 81.505 0.99375 0.993789 OR56B2P - Putative olfactory receptor 56B2 - Homo sapiens (Human) - OR56B2P gene Odorant receptor. Indicus|evm.model.CM009505.1.411 Q6WV90 H4_MYTGA 99.029 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009505.1.412 Q8NGI1 O56B2_HUMAN 82.075 0.990625 0.993789 OR56B2P - Putative olfactory receptor 56B2 - Homo sapiens (Human) - OR56B2P gene Odorant receptor. Indicus|evm.model.CM009505.1.413 Q8NGI1 O56B2_HUMAN 83.529 0.988327 0.798137 OR56B2P - Putative olfactory receptor 56B2 - Homo sapiens (Human) - OR56B2P gene Odorant receptor. Indicus|evm.model.CM009505.1.414 Q8NGI1 O56B2_HUMAN 79.936 0.975078 0.996894 OR56B2P - Putative olfactory receptor 56B2 - Homo sapiens (Human) - OR56B2P gene Odorant receptor. Indicus|evm.model.CM009505.1.415 Q8NGI2 O52N4_HUMAN 84.615 0.920635 0.392523 OR52N4 - Olfactory receptor 52N4 - Homo sapiens (Human) - OR52N4 gene Odorant receptor. Indicus|evm.model.CM009505.1.416 Q8NGI2 O52N4_HUMAN 90.000 0.990521 0.657321 OR52N4 - Olfactory receptor 52N4 - Homo sapiens (Human) - OR52N4 gene Odorant receptor. Indicus|evm.model.CM009505.1.417 Q8NH57 O52P1_HUMAN 87.850 0.993789 1.00312 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Indicus|evm.model.CM009505.1.418 Q8NH57 O52P1_HUMAN 53.401 0.884848 1.02804 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Indicus|evm.model.CM009505.1.419 Q8NGI2 O52N4_HUMAN 52.303 0.92638 1.01558 OR52N4 - Olfactory receptor 52N4 - Homo sapiens (Human) - OR52N4 gene Odorant receptor. Indicus|evm.model.CM009505.1.420 Q8NH57 O52P1_HUMAN 52.769 0.93865 1.01558 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Indicus|evm.model.CM009505.1.421 Q9H346 O52D1_HUMAN 63.253 0.942529 0.54717 OR52D1 - Olfactory receptor 52D1 - Homo sapiens (Human) - OR52D1 gene Odorant receptor. Indicus|evm.model.CM009505.1.422 A5A6H4 ROA1_PANTR 87.550 0.991228 0.7125 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Indicus|evm.model.CM009505.1.423 Q8NGJ2 O52H1_HUMAN 66.879 0.52 0.9375 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.424 Q9EPR4 S23A2_MOUSE 54.479 0.915556 0.694444 Slc23a2 - Solute carrier family 23 member 2 - Mus musculus (Mouse) - Slc23a2 gene Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity). Indicus|evm.model.CM009505.1.425 Q07537 GALT1_BOVIN 96.429 0.776536 0.320215 GALNT1 - Polypeptide N-acetylgalactosaminyltransferase 1 - Bos taurus (Bovine) - GALNT1 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. Indicus|evm.model.CM009505.1.426 Q07537 GALT1_BOVIN 98.674 0.994709 0.676208 GALNT1 - Polypeptide N-acetylgalactosaminyltransferase 1 - Bos taurus (Bovine) - GALNT1 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. Indicus|evm.model.CM009505.1.428 Q8NGJ2 O52H1_HUMAN 74.026 0.977707 0.98125 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.429 Q5D7I9 TRIM5_PYGNE 58.893 0.993988 1.00808 TRIM5 - Tripartite motif-containing protein 5 - Pygathrix nemaeus (Red-shanked douc langur) - TRIM5 gene Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Indicus|evm.model.CM009505.1.430 Q5D7I9 TRIM5_PYGNE 63.448 0.762533 0.765657 TRIM5 - Tripartite motif-containing protein 5 - Pygathrix nemaeus (Red-shanked douc langur) - TRIM5 gene Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Indicus|evm.model.CM009505.1.431 Q5D7I9 TRIM5_PYGNE 57.594 0.995968 1.00202 TRIM5 - Tripartite motif-containing protein 5 - Pygathrix nemaeus (Red-shanked douc langur) - TRIM5 gene Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Indicus|evm.model.CM009505.1.432 Q9BYJ4 TRI34_HUMAN 72.245 0.99591 1.00205 TRIM34 - Tripartite motif-containing protein 34 - Homo sapiens (Human) - TRIM34 gene May function as antiviral protein and may contribute to the defense against retroviral infections. Indicus|evm.model.CM009505.1.434 Q9C030 TRIM6_HUMAN 83.607 0.791531 1.2582 TRIM6 - Tripartite motif-containing protein 6 - Homo sapiens (Human) - TRIM6 gene E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218, PubMed:31694946). In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218). Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Indicus|evm.model.CM009505.1.435 Q8NGF0 O52B6_HUMAN 85.930 0.99 0.597015 OR52B6 - Olfactory receptor 52B6 - Homo sapiens (Human) - OR52B6 gene Odorant receptor. Indicus|evm.model.CM009505.1.436 Q8NGJ2 O52H1_HUMAN 67.606 0.971831 0.44375 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.437 Q8NGJ2 O52H1_HUMAN 80.195 0.983974 0.975 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.438 Q8NGJ2 O52H1_HUMAN 89.677 0.980952 0.984375 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.439 Q8NGJ2 O52H1_HUMAN 77.273 0.971338 0.98125 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.440 Q8NGJ2 O52H1_HUMAN 87.861 0.843137 0.6375 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.441 Q9H346 O52D1_HUMAN 48.311 0.418124 1.97799 OR52D1 - Olfactory receptor 52D1 - Homo sapiens (Human) - OR52D1 gene Odorant receptor. Indicus|evm.model.CM009505.1.442 Q8IYU4 UBQLN_HUMAN 69.462 0.760135 1.24632 UBQLNL - Ubiquilin-like protein - Homo sapiens (Human) - UBQLNL gene cytosol, polyubiquitin modification-dependent protein binding, ubiquitin-dependent protein catabolic process Indicus|evm.model.CM009505.1.443 Q9H347 UBQL3_HUMAN 79.573 0.995434 1.00305 UBQLN3 - Ubiquilin-3 - Homo sapiens (Human) - UBQLN3 gene cytosol, polyubiquitin modification-dependent protein binding, ubiquitin-dependent protein catabolic process Indicus|evm.model.CM009505.1.445 Q9H346 O52D1_HUMAN 87.421 0.99373 1.00314 OR52D1 - Olfactory receptor 52D1 - Homo sapiens (Human) - OR52D1 gene Odorant receptor. Indicus|evm.model.CM009505.1.446 Q9H346 O52D1_HUMAN 85.915 0.986014 0.449686 OR52D1 - Olfactory receptor 52D1 - Homo sapiens (Human) - OR52D1 gene Odorant receptor. Indicus|evm.model.CM009505.1.447 Q9H346 O52D1_HUMAN 84.591 0.99373 1.00314 OR52D1 - Olfactory receptor 52D1 - Homo sapiens (Human) - OR52D1 gene Odorant receptor. Indicus|evm.model.CM009505.1.448 Q9H344 O51I2_HUMAN 63.710 0.242604 1.625 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.450 Q9H344 O51I2_HUMAN 62.791 0.681275 0.804487 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.451 Q9H344 O51I2_HUMAN 89.423 0.99361 1.00321 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.452 Q9H344 O51I2_HUMAN 89.103 0.99361 1.00321 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.453 Q9H343 O51I1_HUMAN 87.179 0.987302 1.00318 OR51I1 - Olfactory receptor 51I1 - Homo sapiens (Human) - OR51I1 gene Odorant receptor. Indicus|evm.model.CM009505.1.454 Q9H344 O51I2_HUMAN 56.897 0.911672 1.01603 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.455 Q8NH59 O51Q1_HUMAN 86.364 0.240223 0.564669 OR51Q1 - Olfactory receptor 51Q1 - Homo sapiens (Human) - OR51Q1 gene Odorant receptor. Indicus|evm.model.CM009505.1.456 Q8NH59 O51Q1_HUMAN 79.808 0.99361 0.987382 OR51Q1 - Olfactory receptor 51Q1 - Homo sapiens (Human) - OR51Q1 gene Odorant receptor. Indicus|evm.model.CM009505.1.457 Q9H342 O51J1_HUMAN 59.517 0.993711 1.00633 OR51J1 - Olfactory receptor 51J1 - Homo sapiens (Human) - OR51J1 gene Odorant receptor. Indicus|evm.model.CM009505.1.458 Q8NGK0 O51G2_HUMAN 56.627 0.976378 0.808917 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Indicus|evm.model.CM009505.1.459 Q8NGK1 O51G1_HUMAN 52.846 0.748466 0.507788 OR51G1 - Olfactory receptor 51G1 - Homo sapiens (Human) - OR51G1 gene Odorant receptor. Indicus|evm.model.CM009505.1.460 Q9H341 O51M1_HUMAN 85.714 0.983051 0.542945 OR51M1 - Olfactory receptor 51M1 - Homo sapiens (Human) - OR51M1 gene Odorant receptor. Indicus|evm.model.CM009505.1.461 Q9H341 O51M1_HUMAN 73.333 0.90303 0.506135 OR51M1 - Olfactory receptor 51M1 - Homo sapiens (Human) - OR51M1 gene Odorant receptor. Indicus|evm.model.CM009505.1.463 P02102 HBE1_CAPHI 100.000 0.986486 1.0068 HBE1 - Hemoglobin subunit epsilon-1 - Capra hircus (Goat) - HBE1 gene Beta-type chain found in early embryos. Indicus|evm.model.CM009505.1.464 P06643 HBE4_BOVIN 100.000 0.986486 1.0068 HBE4 - Hemoglobin subunit epsilon-4 - Bos taurus (Bovine) - HBE4 gene Hemoglobin epsilon chain is a beta-type chain found in early embryos. Indicus|evm.model.CM009505.1.465 P04346 HBBA_BOSJA 97.931 0.986301 1.0069 Hemoglobin subunit beta-A - Bos javanicus (Wild banteng) Indicus|evm.model.CM009505.1.466 P06642 HBE2_BOVIN 97.931 0.358209 2.73469 HBE2 - Hemoglobin subunit epsilon-2 - Bos taurus (Bovine) - HBE2 gene Hemoglobin epsilon chain is a beta-type chain found in early embryos. Indicus|evm.model.CM009505.1.467 P02081 HBBF_BOVIN 100.000 0.986301 1.0069 Hemoglobin fetal subunit beta - Bos taurus (Bovine) Indicus|evm.model.CM009505.1.468 Q9H2C8 O51V1_HUMAN 87.220 0.987302 0.981308 OR51V1 - Olfactory receptor 51V1 - Homo sapiens (Human) - OR51V1 gene Odorant receptor. Indicus|evm.model.CM009505.1.469 P0C646 O52Z1_HUMAN 85.714 0.536232 0.694631 OR52Z1 - Olfactory receptor 52Z1 - Homo sapiens (Human) - OR52Z1 gene Odorant receptor. Indicus|evm.model.CM009505.1.470 Q9UKL2 O52A1_HUMAN 83.013 0.99361 1.00321 OR52A1 - Olfactory receptor 52A1 - Homo sapiens (Human) - OR52A1 gene Odorant receptor. Indicus|evm.model.CM009505.1.471 Q9UKL2 O52A1_HUMAN 83.013 0.981073 1.01603 OR52A1 - Olfactory receptor 52A1 - Homo sapiens (Human) - OR52A1 gene Odorant receptor. Indicus|evm.model.CM009505.1.472 Q9UKL2 O52A1_HUMAN 76.531 0.673611 0.461538 OR52A1 - Olfactory receptor 52A1 - Homo sapiens (Human) - OR52A1 gene Odorant receptor. Indicus|evm.model.CM009505.1.473 Q9H2C5 O52A5_HUMAN 90.476 0.925926 0.427215 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Indicus|evm.model.CM009505.1.474 Q9H2C8 O51V1_HUMAN 87.540 0.987302 0.981308 OR51V1 - Olfactory receptor 51V1 - Homo sapiens (Human) - OR51V1 gene Odorant receptor. Indicus|evm.model.CM009505.1.475 P02081 HBBF_BOVIN 98.148 0.493088 1.49655 Hemoglobin fetal subunit beta - Bos taurus (Bovine) Indicus|evm.model.CM009505.1.476 Q8NH61 O51F2_HUMAN 62.821 0.987302 0.921053 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Indicus|evm.model.CM009505.1.477 Q8NH61 O51F2_HUMAN 64.734 0.936364 0.643275 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Indicus|evm.model.CM009505.1.478 A6NGY5 O51F1_HUMAN 80.982 0.987805 0.514107 OR51F1 - Olfactory receptor 51F1 - Homo sapiens (Human) - OR51F1 gene Odorant receptor. Indicus|evm.model.CM009505.1.479 A6NGY5 O51F1_HUMAN 66.230 0.967949 0.978056 OR51F1 - Olfactory receptor 51F1 - Homo sapiens (Human) - OR51F1 gene Odorant receptor. Indicus|evm.model.CM009505.1.480 A6NGY5 O51F1_HUMAN 65.728 0.954545 0.689655 OR51F1 - Olfactory receptor 51F1 - Homo sapiens (Human) - OR51F1 gene Odorant receptor. Indicus|evm.model.CM009505.1.481 Q8NGF1 O52R1_HUMAN 82.329 0.957529 0.822222 OR52R1 - Olfactory receptor 52R1 - Homo sapiens (Human) - OR52R1 gene Odorant receptor. Indicus|evm.model.CM009505.1.482 Q8NH61 O51F2_HUMAN 87.540 0.984227 0.926901 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Indicus|evm.model.CM009505.1.483 Q8NH64 O51A7_HUMAN 75.410 0.958991 1.01603 OR51A7 - Olfactory receptor 51A7 - Homo sapiens (Human) - OR51A7 gene Odorant receptor. Indicus|evm.model.CM009505.1.484 Q8NGJ8 O51S1_HUMAN 80.435 0.993808 1 OR51S1 - Olfactory receptor 51S1 - Homo sapiens (Human) - OR51S1 gene Odorant receptor. Indicus|evm.model.CM009505.1.485 Q8NH63 O51H1_HUMAN 59.603 0.940439 1.05629 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.486 Q8NH63 O51H1_HUMAN 75.748 0.866667 1.14238 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.487 Q8NGJ9 O51T1_HUMAN 77.259 0.906516 1.07951 OR51T1 - Olfactory receptor 51T1 - Homo sapiens (Human) - OR51T1 gene Odorant receptor. Indicus|evm.model.CM009505.1.488 Q8NH61 O51F2_HUMAN 88.179 0.984227 0.926901 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Indicus|evm.model.CM009505.1.489 Q8NGJ8 O51S1_HUMAN 82.410 0.993506 0.95356 OR51S1 - Olfactory receptor 51S1 - Homo sapiens (Human) - OR51S1 gene Odorant receptor. Indicus|evm.model.CM009505.1.490 Q8NH63 O51H1_HUMAN 61.258 0.940439 1.05629 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.491 Q8NH63 O51H1_HUMAN 69.318 0.930612 0.811258 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.492 Q8NH63 O51H1_HUMAN 55.952 0.893048 0.619205 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.493 Q8NGJ9 O51T1_HUMAN 77.370 0.993902 1.00306 OR51T1 - Olfactory receptor 51T1 - Homo sapiens (Human) - OR51T1 gene Odorant receptor. Indicus|evm.model.CM009505.1.494 Q8NGK0 O51G2_HUMAN 90.602 0.496255 1.70064 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Indicus|evm.model.CM009505.1.495 Q8NGK3 O52K2_HUMAN 54.400 0.846416 0.933121 OR52K2 - Olfactory receptor 52K2 - Homo sapiens (Human) - OR52K2 gene Odorant receptor. Indicus|evm.model.CM009505.1.496 Q8NGJ4 O52E2_HUMAN 86.719 0.984496 0.396923 OR52E2 - Olfactory receptor 52E2 - Homo sapiens (Human) - OR52E2 gene Odorant receptor. Indicus|evm.model.CM009505.1.497 Q8NGH9 O52E4_HUMAN 70.833 0.971875 1.02564 OR52E4 - Olfactory receptor 52E4 - Homo sapiens (Human) - OR52E4 gene Odorant receptor. Indicus|evm.model.CM009505.1.498 Q8NGJ4 O52E2_HUMAN 84.076 0.981191 0.981538 OR52E2 - Olfactory receptor 52E2 - Homo sapiens (Human) - OR52E2 gene Odorant receptor. Indicus|evm.model.CM009505.1.499 Q9H346 O52D1_HUMAN 57.239 0.837143 1.10063 OR52D1 - Olfactory receptor 52D1 - Homo sapiens (Human) - OR52D1 gene Odorant receptor. Indicus|evm.model.CM009505.1.500 Q8NGK1 O51G1_HUMAN 57.860 0.911315 1.01869 OR51G1 - Olfactory receptor 51G1 - Homo sapiens (Human) - OR51G1 gene Odorant receptor. Indicus|evm.model.CM009505.1.501 Q8NGJ5 O51L1_HUMAN 58.678 0.888889 0.428571 OR51L1 - Olfactory receptor 51L1 - Homo sapiens (Human) - OR51L1 gene Odorant receptor. Indicus|evm.model.CM009505.1.502 Q9UKL2 O52A1_HUMAN 83.333 0.99361 1.00321 OR52A1 - Olfactory receptor 52A1 - Homo sapiens (Human) - OR52A1 gene Odorant receptor. Indicus|evm.model.CM009505.1.503 Q9H2C5 O52A5_HUMAN 86.923 0.955556 0.427215 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Indicus|evm.model.CM009505.1.504 Q9H2C8 O51V1_HUMAN 76.948 0.977707 0.978193 OR51V1 - Olfactory receptor 51V1 - Homo sapiens (Human) - OR51V1 gene Odorant receptor. Indicus|evm.model.CM009505.1.505 Q8NH57 O52P1_HUMAN 59.524 0.922652 0.563863 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Indicus|evm.model.CM009505.1.506 Q8NH57 O52P1_HUMAN 57.714 0.977528 0.554517 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Indicus|evm.model.CM009505.1.507 Q9H2C5 O52A5_HUMAN 76.582 0.993631 0.993671 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Indicus|evm.model.CM009505.1.508 Q9H2C8 O51V1_HUMAN 73.312 0.987261 0.978193 OR51V1 - Olfactory receptor 51V1 - Homo sapiens (Human) - OR51V1 gene Odorant receptor. Indicus|evm.model.CM009505.1.509 Q9H2C8 O51V1_HUMAN 77.316 0.984227 0.987539 OR51V1 - Olfactory receptor 51V1 - Homo sapiens (Human) - OR51V1 gene Odorant receptor. Indicus|evm.model.CM009505.1.510 Q8NH63 O51H1_HUMAN 47.126 0.931655 0.92053 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.511 Q8NGK0 O51G2_HUMAN 59.028 0.616379 0.738854 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Indicus|evm.model.CM009505.1.512 Q8NGK0 O51G2_HUMAN 55.631 0.924051 1.00637 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Indicus|evm.model.CM009505.1.513 Q8NGK0 O51G2_HUMAN 64.257 0.727273 1.08599 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Indicus|evm.model.CM009505.1.514 Q8NGK3 O52K2_HUMAN 59.524 0.82 0.159236 OR52K2 - Olfactory receptor 52K2 - Homo sapiens (Human) - OR52K2 gene Odorant receptor. Indicus|evm.model.CM009505.1.515 Q9H2C5 O52A5_HUMAN 58.544 0.990415 0.990506 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Indicus|evm.model.CM009505.1.516 Q8NGJ2 O52H1_HUMAN 52.532 0.923529 0.53125 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.517 Q8NGK5 O52M1_HUMAN 56.040 0.930818 1.00315 OR52M1 - Olfactory receptor 52M1 - Homo sapiens (Human) - OR52M1 gene Odorant receptor. Indicus|evm.model.CM009505.1.518 Q8NGK4 O52K1_HUMAN 50.000 0.980952 1.00318 OR52K1 - Olfactory receptor 52K1 - Homo sapiens (Human) - OR52K1 gene Odorant receptor. Indicus|evm.model.CM009505.1.519 Q9UKL2 O52A1_HUMAN 60.352 0.957265 0.75 OR52A1 - Olfactory receptor 52A1 - Homo sapiens (Human) - OR52A1 gene Odorant receptor. Indicus|evm.model.CM009505.1.520 Q8NH60 O52J3_HUMAN 87.460 0.99359 1.00322 OR52J3 - Olfactory receptor 52J3 - Homo sapiens (Human) - OR52J3 gene Odorant receptor. Indicus|evm.model.CM009505.1.521 Q8NGJ3 O52E1_HUMAN 82.812 0.976923 0.422078 OR52E1 - Olfactory receptor 52E1 - Homo sapiens (Human) - OR52E1 gene Odorant receptor. Indicus|evm.model.CM009505.1.522 Q8NGJ4 O52E2_HUMAN 82.946 0.984615 0.4 OR52E2 - Olfactory receptor 52E2 - Homo sapiens (Human) - OR52E2 gene Odorant receptor. Indicus|evm.model.CM009505.1.523 Q8NGJ3 O52E1_HUMAN 82.292 0.979487 0.633117 OR52E1 - Olfactory receptor 52E1 - Homo sapiens (Human) - OR52E1 gene Odorant receptor. Indicus|evm.model.CM009505.1.524 Q8NH60 O52J3_HUMAN 88.746 0.99359 1.00322 OR52J3 - Olfactory receptor 52J3 - Homo sapiens (Human) - OR52J3 gene Odorant receptor. Indicus|evm.model.CM009505.1.525 Q8NGK0 O51G2_HUMAN 59.839 0.972549 0.812102 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Indicus|evm.model.CM009505.1.526 Q8NGJ5 O51L1_HUMAN 86.218 0.984177 1.00317 OR51L1 - Olfactory receptor 51L1 - Homo sapiens (Human) - OR51L1 gene Odorant receptor. Indicus|evm.model.CM009505.1.527 Q8NH64 O51A7_HUMAN 73.408 0.974359 0.875 OR51A7 - Olfactory receptor 51A7 - Homo sapiens (Human) - OR51A7 gene Odorant receptor. Indicus|evm.model.CM009505.1.528 Q8NGK1 O51G1_HUMAN 93.182 0.988701 0.551402 OR51G1 - Olfactory receptor 51G1 - Homo sapiens (Human) - OR51G1 gene Odorant receptor. Indicus|evm.model.CM009505.1.529 Q8NGK0 O51G2_HUMAN 92.000 0.988095 0.802548 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Indicus|evm.model.CM009505.1.530 Q8NGJ5 O51L1_HUMAN 86.538 0.984177 1.00317 OR51L1 - Olfactory receptor 51L1 - Homo sapiens (Human) - OR51L1 gene Odorant receptor. Indicus|evm.model.CM009505.1.531 Q8NGJ6 O51A4_HUMAN 84.026 0.990476 1.00639 OR51A4 - Olfactory receptor 51A4 - Homo sapiens (Human) - OR51A4 gene Odorant receptor. Indicus|evm.model.CM009505.1.532 Q8NH64 O51A7_HUMAN 65.263 0.959184 0.314103 OR51A7 - Olfactory receptor 51A7 - Homo sapiens (Human) - OR51A7 gene Odorant receptor. Indicus|evm.model.CM009505.1.533 A6NGY5 O51F1_HUMAN 51.136 0.909326 1.21003 OR51F1 - Olfactory receptor 51F1 - Homo sapiens (Human) - OR51F1 gene Odorant receptor. Indicus|evm.model.CM009505.1.534 Q8NH61 O51F2_HUMAN 61.199 0.993651 0.921053 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Indicus|evm.model.CM009505.1.535 Q9H255 O51E2_HUMAN 93.919 0.98 0.46875 OR51E2 - Olfactory receptor 51E2 - Homo sapiens (Human) - OR51E2 gene Olfactory receptor (PubMed:29249973, PubMed:27226631). Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:29249973, PubMed:27226631, PubMed:19389702). The activity of this receptor is propably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973). Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). Activated by L-lactate in glomus cells (By similarity). Indicus|evm.model.CM009505.1.536 Q9H344 O51I2_HUMAN 58.667 0.931464 1.02885 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.537 Q9H344 O51I2_HUMAN 51.667 0.858521 0.996795 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.538 Q9H344 O51I2_HUMAN 58.586 0.922118 1.02885 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.539 Q9H344 O51I2_HUMAN 53.237 0.860248 1.03205 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.540 Q8TCB6 O51E1_HUMAN 93.375 0.993711 1.00315 OR51E1 - Olfactory receptor 51E1 - Homo sapiens (Human) - OR51E1 gene Odorant receptor. Indicus|evm.model.CM009505.1.541 Q8NGF3 O51D1_HUMAN 88.889 0.890052 0.589506 OR51D1 - Olfactory receptor 51D1 - Homo sapiens (Human) - OR51D1 gene Odorant receptor. Indicus|evm.model.CM009505.1.542 Q6AZZ1 TRI68_HUMAN 88.247 0.995885 1.00206 TRIM68 - E3 ubiquitin-protein ligase TRIM68 - Homo sapiens (Human) - TRIM68 gene Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. Indicus|evm.model.CM009505.1.543 Q8NH67 O52I2_HUMAN 81.667 0.988889 0.514286 OR52I2 - Olfactory receptor 52I2 - Homo sapiens (Human) - OR52I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.544 Q8NH67 O52I2_HUMAN 81.173 0.993846 0.928571 OR52I2 - Olfactory receptor 52I2 - Homo sapiens (Human) - OR52I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.545 Q8NH67 O52I2_HUMAN 81.111 0.908629 0.562857 OR52I2 - Olfactory receptor 52I2 - Homo sapiens (Human) - OR52I2 gene Odorant receptor. Indicus|evm.model.CM009505.1.547 Q8NGK4 O52K1_HUMAN 90.640 0.990196 0.649682 OR52K1 - Olfactory receptor 52K1 - Homo sapiens (Human) - OR52K1 gene Odorant receptor. Indicus|evm.model.CM009505.1.548 Q8NGK4 O52K1_HUMAN 92.611 0.990196 0.649682 OR52K1 - Olfactory receptor 52K1 - Homo sapiens (Human) - OR52K1 gene Odorant receptor. Indicus|evm.model.CM009505.1.549 Q8NGK5 O52M1_HUMAN 85.795 0.988701 0.55836 OR52M1 - Olfactory receptor 52M1 - Homo sapiens (Human) - OR52M1 gene Odorant receptor. Indicus|evm.model.CM009505.1.550 Q8NGK4 O52K1_HUMAN 84.615 0.983051 0.375796 OR52K1 - Olfactory receptor 52K1 - Homo sapiens (Human) - OR52K1 gene Odorant receptor. Indicus|evm.model.CM009505.1.551 Q8NGK0 O51G2_HUMAN 53.356 0.933962 1.01274 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Indicus|evm.model.CM009505.1.552 Q7YRV4 RO52_BOVIN 100.000 0.914062 1.09168 TRIM21 - E3 ubiquitin-protein ligase TRIM21 - Bos taurus (Bovine) - TRIM21 gene E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (By similarity). Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI (By similarity). Indicus|evm.model.CM009505.1.553 Q8NGK2 O52B4_HUMAN 61.429 0.972028 0.455414 OR52B4 - Olfactory receptor 52B4 - Homo sapiens (Human) - OR52B4 gene Odorant receptor. Indicus|evm.model.CM009505.1.555 Q8NGK2 O52B4_HUMAN 82.803 0.993651 1.00318 OR52B4 - Olfactory receptor 52B4 - Homo sapiens (Human) - OR52B4 gene Odorant receptor. Indicus|evm.model.CM009505.1.556 Q9CY97 SSU72_MOUSE 53.125 0.933824 0.701031 Ssu72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Mus musculus (Mouse) - Ssu72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. Indicus|evm.model.CM009505.1.557 Q17QI2 SSU72_BOVIN 66.495 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Indicus|evm.model.CM009505.1.558 Q9NP77 SSU72_HUMAN 59.794 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Homo sapiens (Human) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. Indicus|evm.model.CM009505.1.559 Q17QI2 SSU72_BOVIN 63.918 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Indicus|evm.model.CM009505.1.560 Q17QI2 SSU72_BOVIN 56.701 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Indicus|evm.model.CM009505.1.561 Q8NGK2 O52B4_HUMAN 72.727 0.922535 0.452229 OR52B4 - Olfactory receptor 52B4 - Homo sapiens (Human) - OR52B4 gene Odorant receptor. Indicus|evm.model.CM009505.1.562 Q5ZJQ7 SSU72_CHICK 60.221 0.983607 0.943299 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Gallus gallus (Chicken) - SSU72 gene May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination. Indicus|evm.model.CM009505.1.563 Q17QI2 SSU72_BOVIN 63.918 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Indicus|evm.model.CM009505.1.565 Q9UNN5 FAF1_HUMAN 97.450 0.850242 0.636923 FAF1 - FAS-associated factor 1 - Homo sapiens (Human) - FAF1 gene Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). Indicus|evm.model.CM009505.1.566 Q17QI2 SSU72_BOVIN 63.402 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Indicus|evm.model.CM009505.1.571 P23921 RIR1_HUMAN 97.854 0.997475 1 RRM1 - Ribonucleoside-diphosphate reductase large subunit - Homo sapiens (Human) - RRM1 gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Indicus|evm.model.CM009505.1.572 Q58CP9 STIM1_BOVIN 100.000 0.997076 1.00146 STIM1 - Stromal interaction molecule 1 precursor - Bos taurus (Bovine) - STIM1 gene Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch. Indicus|evm.model.CM009505.1.573 P84096 RHOG_MOUSE 98.953 0.989583 1.00524 Rhog - Rho-related GTP-binding protein RhoG precursor - Mus musculus (Mouse) - Rhog gene Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity). Indicus|evm.model.CM009505.1.574 A6H7B8 PGAP2_BOVIN 100.000 0.744118 1.33858 PGAP2 - Post-GPI attachment to proteins factor 2 - Bos taurus (Bovine) - PGAP2 gene Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity). Indicus|evm.model.CM009505.1.575 P52948 NUP98_HUMAN 93.722 0.998349 1 NUP98 - Nuclear pore complex protein Nup98-Nup96 precursor - Homo sapiens (Human) - NUP98 gene Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). Indicus|evm.model.CM009505.1.576 Q9GZZ6 ACH10_HUMAN 88.372 0.936681 1.01778 CHRNA10 - Neuronal acetylcholine receptor subunit alpha-10 precursor - Homo sapiens (Human) - CHRNA10 gene Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Indicus|evm.model.CM009505.1.577 P52961 NAR1_HUMAN 83.792 0.993884 1 ART1 - GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor - Homo sapiens (Human) - ART1 gene Has ADP-ribosyltransferase activity toward GLP1R. Indicus|evm.model.CM009505.1.578 Q0VC22 NAR5_BOVIN 99.051 0.499208 1.99684 ART5 - Ecto-ADP-ribosyltransferase 5 precursor - Bos taurus (Bovine) - ART5 gene NAD+ ADP-ribosyltransferase activity, peptidyl-arginine ADP-ribosylation Indicus|evm.model.CM009505.1.579 Q0VC22 NAR5_BOVIN 83.276 0.941935 0.981013 ART5 - Ecto-ADP-ribosyltransferase 5 precursor - Bos taurus (Bovine) - ART5 gene NAD+ ADP-ribosyltransferase activity, peptidyl-arginine ADP-ribosylation Indicus|evm.model.CM009505.1.580 O62826 TRPC2_BOVIN 100.000 0.341251 2.92361 TRPC2 - Short transient receptor potential channel 2 homolog - Bos taurus (Bovine) - TRPC2 gene Thought to form a receptor-activated calcium permeant cation channel. Indicus|evm.model.CM009505.1.581 Q9H920 RN121_HUMAN 98.471 0.993902 1.00306 RNF121 - RING finger protein 121 - Homo sapiens (Human) - RNF121 gene endoplasmic reticulum membrane, Golgi membrane, ubiquitin protein ligase activity, endoplasmic reticulum unfolded protein response, ubiquitin-dependent ERAD pathway Indicus|evm.model.CM009505.1.582 O95998 I18BP_HUMAN 68.085 0.880952 1.08247 IL18BP - Interleukin-18-binding protein precursor - Homo sapiens (Human) - IL18BP gene Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. Indicus|evm.model.CM009505.1.583 Q14980 NUMA1_HUMAN 85.620 0.999058 1.00426 NUMA1 - Nuclear mitotic apparatus protein 1 - Homo sapiens (Human) - NUMA1 gene Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). Indicus|evm.model.CM009505.1.584 Q5EAD8 LRC51_BOVIN 100.000 0.989637 1.00521 LRRC51 - Leucine-rich repeat-containing protein 51 - Bos taurus (Bovine) - LRRC51 gene Indicus|evm.model.CM009505.1.585 Q3T0D8 LTOR1_BOVIN 100.000 0.987654 1.00621 LAMTOR1 - Ragulator complex protein LAMTOR1 - Bos taurus (Bovine) - LAMTOR1 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity). Indicus|evm.model.CM009505.1.586 Q8WZ04 TOMT_HUMAN 96.124 0.992278 0.890034 LRTOMT - Transmembrane O-methyltransferase - Homo sapiens (Human) - LRTOMT gene Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (PubMed:18794526). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity). Indicus|evm.model.CM009505.1.587 Q3SZ31 APC15_BOVIN 100.000 0.983607 1.00826 ANAPC15 - Anaphase-promoting complex subunit 15 - Bos taurus (Bovine) - ANAPC15 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 (By similarity). Indicus|evm.model.CM009505.1.588 P02702 FOLR1_BOVIN 100.000 0.428884 1.89627 FOLR1 - Folate receptor alpha precursor - Bos taurus (Bovine) - FOLR1 gene Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation (By similarity). Indicus|evm.model.CM009505.1.589 O15357 SHIP2_HUMAN 97.052 0.837912 1.15739 INPPL1 - Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 - Homo sapiens (Human) - INPPL1 gene Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification. Indicus|evm.model.CM009505.1.590 O14813 PHX2A_HUMAN 98.592 0.992982 1.00352 PHOX2A - Paired mesoderm homeobox protein 2A - Homo sapiens (Human) - PHOX2A gene May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. Indicus|evm.model.CM009505.1.591 Q5E9N5 CLPB_BOVIN 99.413 0.997067 1.00739 CLPB - Caseinolytic peptidase B protein homolog precursor - Bos taurus (Bovine) - CLPB gene May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6. Indicus|evm.model.CM009505.1.592 P14099 PDE2A_BOVIN 99.891 0.997831 1.00109 PDE2A - cGMP-dependent 3',5'-cyclic phosphodiesterase - Bos taurus (Bovine) - PDE2A gene Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Indicus|evm.model.CM009505.1.593 Q96P48 ARAP1_HUMAN 89.553 0.967807 1.02828 ARAP1 - Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 - Homo sapiens (Human) - ARAP1 gene Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). Indicus|evm.model.CM009505.1.594 Q9Y365 STA10_HUMAN 94.502 0.881459 1.13058 STARD10 - START domain-containing protein 10 - Homo sapiens (Human) - STARD10 gene May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes. Indicus|evm.model.CM009505.1.595 Q8NAA4 A16L2_HUMAN 85.784 0.996759 0.996769 ATG16L2 - Protein Atg16l2 - Homo sapiens (Human) - ATG16L2 gene May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner. Indicus|evm.model.CM009505.1.596 O94868 FCSD2_HUMAN 97.027 0.997301 1.00135 FCHSD2 - F-BAR and double SH3 domains protein 2 - Homo sapiens (Human) - FCHSD2 gene Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). Indicus|evm.model.CM009505.1.597 O18951 P2RY2_BOVIN 97.744 0.349206 2.84211 P2RY2 - P2Y purinoceptor 2 - Bos taurus (Bovine) - P2RY2 gene Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009505.1.598 Q15077 P2RY6_HUMAN 92.683 0.993921 1.00305 P2RY6 - P2Y purinoceptor 6 - Homo sapiens (Human) - P2RY6 gene Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009505.1.599 Q96PE2 ARHGH_HUMAN 90.073 0.999031 1 ARHGEF17 - Rho guanine nucleotide exchange factor 17 - Homo sapiens (Human) - ARHGEF17 gene Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Indicus|evm.model.CM009505.1.601 Q969Z4 TR19L_HUMAN 82.464 0.976798 1.00233 RELT - Tumor necrosis factor receptor superfamily member 19L precursor - Homo sapiens (Human) - RELT gene May play a role in apoptosis (PubMed:28688764, PubMed:19969290). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727). Involved in dental enamel formation (PubMed:30506946). Indicus|evm.model.CM009505.1.602 Q8BGZ2 F168A_MOUSE 99.590 0.852632 1.16803 Fam168a - Protein FAM168A - Mus musculus (Mouse) - Fam168a gene In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels. Indicus|evm.model.CM009505.1.603 Q9UF11 PKHB1_HUMAN 82.305 0.990431 0.860082 PLEKHB1 - Pleckstrin homology domain-containing family B member 1 - Homo sapiens (Human) - PLEKHB1 gene integral component of membrane, phototransduction, regulation of cell differentiation Indicus|evm.model.CM009505.1.604 Q9WVB1 RAB6A_RAT 88.942 0.989362 0.903846 Rab6a - Ras-related protein Rab-6A - Rattus norvegicus (Rat) - Rab6a gene Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER. Indicus|evm.model.CM009505.1.605 Q2YDI5 RM48_BOVIN 99.029 0.836735 1.15566 MRPL48 - 39S ribosomal protein L48, mitochondrial precursor - Bos taurus (Bovine) - MRPL48 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome Indicus|evm.model.CM009505.1.606 Q8BT51 COA4_MOUSE 87.342 0.917647 0.977011 COA4 - Cytochrome c oxidase assembly factor 4 homolog, mitochondrial - Mus musculus (Mouse) - COA4 gene Putative COX assembly factor. Indicus|evm.model.CM009505.1.607 Q148I1 PAAF1_BOVIN 100.000 0.994911 1.00255 PAAF1 - Proteasomal ATPase-associated factor 1 - Bos taurus (Bovine) - PAAF1 gene Inhibits proteasome 26S assembly and activity by impairing the association of the 19S regulatory complex with the 20S core. Protects SUPT6H from proteasomal degradation (By similarity). Indicus|evm.model.CM009505.1.608 P59910 DJB13_HUMAN 92.089 0.993691 1.00316 DNAJB13 - DnaJ homolog subfamily B member 13 - Homo sapiens (Human) - DNAJB13 gene Plays a role in the formation of the central complex of ciliary and flagellar axonemes. Indicus|evm.model.CM009505.1.609 Q3SZI5 UCP2_BOVIN 100.000 0.993548 1.00324 UCP2 - Mitochondrial uncoupling protein 2 - Bos taurus (Bovine) - UCP2 gene UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). Indicus|evm.model.CM009505.1.611 O77792 UCP3_BOVIN 99.678 0.99359 1.00322 UCP3 - Mitochondrial uncoupling protein 3 - Bos taurus (Bovine) - UCP3 gene UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity). Indicus|evm.model.CM009505.1.612 Q4AC94 C2CD3_HUMAN 82.655 0.999147 0.997025 C2CD3 - C2 domain-containing protein 3 - Homo sapiens (Human) - C2CD3 gene Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. Indicus|evm.model.CM009505.1.613 Q58DN4 PPME1_BOVIN 89.737 0.977011 0.915789 PPME1 - Protein phosphatase methylesterase 1 - Bos taurus (Bovine) - PPME1 gene Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity). Indicus|evm.model.CM009505.1.614 Q75UG4 P4HA3_BOVIN 100.000 0.99633 1.00184 P4HA3 - Prolyl 4-hydroxylase subunit alpha-3 precursor - Bos taurus (Bovine) - P4HA3 gene Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Indicus|evm.model.CM009505.1.615 P83883 RL36A_RAT 100.000 0.981308 1.00943 Rpl36a - 60S ribosomal protein L36a - Rattus norvegicus (Rat) - Rpl36a gene cytosolic large ribosomal subunit, nucleus, response to organic substance, response to retinoic acid Indicus|evm.model.CM009505.1.616 Q5R979 PGM2L_PONAB 96.463 0.99679 1.00161 PGM2L1 - Glucose 1,6-bisphosphate synthase - Pongo abelii (Sumatran orangutan) - PGM2L1 gene Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars as acceptors, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate. 5 or 6-phosphosugars are bad substrates, with the exception of glucose 6-phosphate. Also synthesizes ribose 1,5-bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities (By similarity). Indicus|evm.model.CM009505.1.617 Q9Y6H6 KCNE3_HUMAN 88.350 0.98 0.970874 KCNE3 - Potassium voltage-gated channel subfamily E member 3 - Homo sapiens (Human) - KCNE3 gene Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. Indicus|evm.model.CM009505.1.619 A6NK58 LIPT2_HUMAN 83.983 0.99115 0.978355 LIPT2 - Putative lipoyltransferase 2, mitochondrial precursor - Homo sapiens (Human) - LIPT2 gene Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes, which catalyze essential redox reactions (PubMed:28757203). Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). Indicus|evm.model.CM009505.1.620 P84798 DPOD3_BOVIN 94.850 0.995699 0.997854 POLD3 - DNA polymerase delta subunit 3 - Bos taurus (Bovine) - POLD3 gene Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS, as a component of the tetrametric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7. Indicus|evm.model.CM009505.1.621 Q6WN34 CRDL2_HUMAN 89.276 0.821192 1.05594 CHRDL2 - Chordin-like protein 2 precursor - Homo sapiens (Human) - CHRDL2 gene May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. Indicus|evm.model.CM009505.1.622 Q9HC38 GLOD4_HUMAN 69.903 0.962264 0.338658 GLOD4 - Glyoxalase domain-containing protein 4 - Homo sapiens (Human) - GLOD4 gene extracellular exosome, cadherin binding Indicus|evm.model.CM009505.1.623 F1MRW8 RN169_BOVIN 100.000 0.995893 0.706821 RNF169 - E3 ubiquitin-protein ligase RNF169 - Bos taurus (Bovine) - RNF169 gene Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. Indicus|evm.model.CM009505.1.624 Q7PCK7 XRRA1_BOVIN 90.134 0.725395 1.49909 XRRA1 - X-ray radiation resistance-associated protein 1 - Bos taurus (Bovine) - XRRA1 gene May be involved in the response of cells to X-ray radiation. Indicus|evm.model.CM009505.1.625 Q9CYN2 SPCS2_MOUSE 89.815 0.784672 1.21239 Spcs2 - Signal peptidase complex subunit 2 - Mus musculus (Mouse) - Spcs2 gene Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Indicus|evm.model.CM009505.1.626 O97859 NEUR3_BOVIN 99.299 0.972665 1.0257 NEU3 - Sialidase-3 - Bos taurus (Bovine) - NEU3 gene Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:9988745). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (By similarity). Indicus|evm.model.CM009505.1.627 O94956 SO2B1_HUMAN 81.100 0.92549 1.07898 SLCO2B1 - Solute carrier organic anion transporter family member 2B1 - Homo sapiens (Human) - SLCO2B1 gene Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. Indicus|evm.model.CM009505.1.628 P0DKB5 TPBGL_HUMAN 90.231 0.994872 1.02094 TPBGL - Trophoblast glycoprotein-like precursor - Homo sapiens (Human) - TPBGL gene Indicus|evm.model.CM009505.1.629 P17870 ARRB1_BOVIN 100.000 0.995227 1.00239 ARRB1 - Beta-arrestin-1 - Bos taurus (Bovine) - ARRB1 gene Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in IL8-mediated granule release in neutrophils. Binds phosphoinositides. Binds inositol hexakisphosphate (InsP6) (By similarity). Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates in the recruitment of the ubiquitin-protein ligase to the receptor (By similarity). Indicus|evm.model.CM009505.1.630 Q0Z8U2 RS3_PIG 100.000 0.991803 1.00412 RPS3 - 40S ribosomal protein S3 - Sus scrofa (Pig) - RPS3 gene Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein OGG1. Enhances the uracil excision activity of UNG1. Also stimulates the cleavage of the phosphodiester backbone by APEX1. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide. Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes. Represses its own translation by binding to its cognate mRNA. Binds to and protects TP53/p53 from MDM2-mediated ubiquitination. Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization. Involved in induction of apoptosis through its role in activation of CASP8. Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation. Indicus|evm.model.CM009505.1.631 Q6PF15 KLH35_HUMAN 89.971 0.754881 0.790738 KLHL35 - Kelch-like protein 35 - Homo sapiens (Human) - KLHL35 gene Indicus|evm.model.CM009505.1.632 Q8WTR4 GDPD5_HUMAN 92.727 0.9967 1.00165 GDPD5 - Glycerophosphodiester phosphodiesterase domain-containing protein 5 - Homo sapiens (Human) - GDPD5 gene Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). Indicus|evm.model.CM009505.1.633 Q2KJH6 SERPH_BOVIN 100.000 0.914474 1.09091 SERPINH1 - Serpin H1 precursor - Bos taurus (Bovine) - SERPINH1 gene Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity). Indicus|evm.model.CM009505.1.635 Q96JE9 MAP6_HUMAN 88.406 0.377289 0.671587 MAP6 - Microtubule-associated protein 6 - Homo sapiens (Human) - MAP6 gene Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). Indicus|evm.model.CM009505.1.636 Q3SYC2 MOGT2_HUMAN 73.353 0.99403 1.00299 MOGAT2 - 2-acylglycerol O-acyltransferase 2 - Homo sapiens (Human) - MOGAT2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Indicus|evm.model.CM009505.1.637 Q80W94 MOGT2_MOUSE 69.670 0.990881 0.98503 Mogat2 - 2-acylglycerol O-acyltransferase 2 - Mus musculus (Mouse) - Mogat2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Indicus|evm.model.CM009505.1.639 Q80W94 MOGT2_MOUSE 78.033 0.952978 0.95509 Mogat2 - 2-acylglycerol O-acyltransferase 2 - Mus musculus (Mouse) - Mogat2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Indicus|evm.model.CM009505.1.640 Q80W94 MOGT2_MOUSE 71.486 0.972441 0.760479 Mogat2 - 2-acylglycerol O-acyltransferase 2 - Mus musculus (Mouse) - Mogat2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Indicus|evm.model.CM009505.1.641 Q9P0L2 MARK1_HUMAN 82.988 0.990783 0.272956 MARK1 - Serine/threonine-protein kinase MARK1 - Homo sapiens (Human) - MARK1 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Indicus|evm.model.CM009505.1.642 Q9P0L2 MARK1_HUMAN 74.886 0.907652 0.47673 MARK1 - Serine/threonine-protein kinase MARK1 - Homo sapiens (Human) - MARK1 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Indicus|evm.model.CM009505.1.643 Q3SYC2 MOGT2_HUMAN 60.811 0.990196 0.610778 MOGAT2 - 2-acylglycerol O-acyltransferase 2 - Homo sapiens (Human) - MOGAT2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Indicus|evm.model.CM009505.1.644 Q80W94 MOGT2_MOUSE 67.066 0.993994 0.997006 Mogat2 - 2-acylglycerol O-acyltransferase 2 - Mus musculus (Mouse) - Mogat2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Indicus|evm.model.CM009505.1.645 Q70VZ8 DGAT2_BOVIN 99.723 0.994475 1.00277 DGAT2 - Diacylglycerol O-acyltransferase 2 - Bos taurus (Bovine) - DGAT2 gene Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (By similarity). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Indicus|evm.model.CM009505.1.646 Q9P2Y5 UVRAG_HUMAN 93.419 0.997143 1.00143 UVRAG - UV radiation resistance-associated gene protein - Homo sapiens (Human) - UVRAG gene Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). Indicus|evm.model.CM009505.1.647 O96014 WNT11_HUMAN 98.305 0.994366 1.00282 WNT11 - Protein Wnt-11 precursor - Homo sapiens (Human) - WNT11 gene Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Indicus|evm.model.CM009505.1.648 O43422 P52K_HUMAN 96.850 0.997379 1.00263 THAP12 - 52 kDa repressor of the inhibitor of the protein kinase - Homo sapiens (Human) - THAP12 gene Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. Indicus|evm.model.CM009505.1.649 Q3ZCU0 GVQW3_HUMAN 94.656 0.693548 0.732283 GVQW3 - Protein GVQW3 - Homo sapiens (Human) - GVQW3 gene Indicus|evm.model.CM009505.1.650 Q7Z589 EMSY_HUMAN 96.036 0.998489 1.00151 EMSY - BRCA2-interacting transcriptional repressor EMSY - Homo sapiens (Human) - EMSY gene Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Indicus|evm.model.CM009505.1.651 Q14392 LRC32_HUMAN 84.961 0.463203 2.09366 LRRC32 - Transforming growth factor beta activator LRRC32 precursor - Homo sapiens (Human) - LRRC32 gene Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity). Indicus|evm.model.CM009505.1.652 Q8WUA8 TSK_HUMAN 84.703 0.980501 1.017 TSKU - Tsukushi precursor - Homo sapiens (Human) - TSKU gene Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis. Indicus|evm.model.CM009505.1.654 Q9NUN7 ACER3_HUMAN 94.382 0.992537 1.00375 ACER3 - Alkaline ceramidase 3 - Homo sapiens (Human) - ACER3 gene Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:20068046, PubMed:26792856, PubMed:20207939, PubMed:11356846, PubMed:30575723). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20068046). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (PubMed:20207939). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity). Indicus|evm.model.CM009505.1.655 O77737 B2CL1_PIG 77.215 0.52 0.643777 BCL2L1 - Bcl-2-like protein 1 - Sus scrofa (Pig) - BCL2L1 gene Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). Indicus|evm.model.CM009505.1.656 Q6ZMB0 B3GN6_HUMAN 80.729 0.994737 0.989583 B3GNT6 - Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase - Homo sapiens (Human) - B3GNT6 gene Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs. Indicus|evm.model.CM009505.1.657 P57053 H2BFS_HUMAN 89.744 0.6875 0.888889 H2BS1 - Histone H2B type F-S - Homo sapiens (Human) - H2BS1 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009505.1.658 O15484 CAN5_HUMAN 93.438 0.99688 1.00156 CAPN5 - Calpain-5 - Homo sapiens (Human) - CAPN5 gene Calcium-regulated non-lysosomal thiol-protease. Indicus|evm.model.CM009505.1.659 Q28970 MYO7A_PIG 96.964 0.251467 3.91343 MYO7A - Unconventional myosin-VIIa - Sus scrofa (Pig) - MYO7A gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Indicus|evm.model.CM009505.1.660 Q3TT99 GDPD4_MOUSE 62.500 0.269303 0.84019 Gdpd4 - Glycerophosphodiester phosphodiesterase domain-containing protein 4 - Mus musculus (Mouse) - Gdpd4 gene Indicus|evm.model.CM009505.1.661 Q9BYT9 ANO3_HUMAN 90.412 0.990556 0.971458 ANO3 - Anoctamin-3 - Homo sapiens (Human) - ANO3 gene Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:21984732). Indicus|evm.model.CM009505.1.662 A7MBD8 SC5AC_BOVIN 99.838 0.996764 1.00162 SLC5A12 - Sodium-coupled monocarboxylate transporter 2 - Bos taurus (Bovine) - SLC5A12 gene Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). Indicus|evm.model.CM009505.1.663 Q5E9H1 FIBIN_BOVIN 100.000 0.990566 1.00474 FIBIN - Fin bud initiation factor homolog precursor - Bos taurus (Bovine) - FIBIN gene Indicus|evm.model.CM009505.1.664 O75936 BODG_HUMAN 87.080 0.994845 1.00258 BBOX1 - Gamma-butyrobetaine dioxygenase - Homo sapiens (Human) - BBOX1 gene Catalyzes the formation of L-carnitine from gamma-butyrobetaine. Indicus|evm.model.CM009505.1.665 Q96HJ3 CCD34_HUMAN 78.226 0.986413 0.986595 CCDC34 - Coiled-coil domain-containing protein 34 - Homo sapiens (Human) - CCDC34 gene Indicus|evm.model.CM009505.1.666 F1MLX5 LGR4_BOVIN 100.000 0.957929 0.974763 LGR4 - Leucine-rich repeat-containing G-protein coupled receptor 4 precursor - Bos taurus (Bovine) - LGR4 gene Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however required additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP. Indicus|evm.model.CM009505.1.668 Q792I0 LIN7C_RAT 100.000 0.989899 1.00508 Lin7c - Protein lin-7 homolog C - Rattus norvegicus (Rat) - Lin7c gene Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Indicus|evm.model.CM009505.1.669 Q95106 BDNF_BOVIN 100.000 0.992032 1.004 BDNF - Brain-derived neurotrophic factor precursor - Bos taurus (Bovine) - BDNF gene Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity). Indicus|evm.model.CM009505.1.670 Q8NI77 KI18A_HUMAN 91.714 0.685714 0.857461 KIF18A - Kinesin-like protein KIF18A - Homo sapiens (Human) - KIF18A gene Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. Indicus|evm.model.CM009505.1.671 A0JN95 MET15_BOVIN 99.754 0.708551 1.40786 METTL15 - 12S rRNA N4-methylcytidine methyltransferase precursor - Bos taurus (Bovine) - METTL15 gene N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits. Indicus|evm.model.CM009505.1.673 Q05037 KCNA4_BOVIN 99.244 0.996979 1.00303 KCNA4 - Potassium voltage-gated channel subfamily A member 4 - Bos taurus (Bovine) - KCNA4 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:1505668). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:1505668). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (By similarity). Indicus|evm.model.CM009505.1.675 P04837 FSHB_BOVIN 100.000 0.984615 1.00775 FSHB - Follitropin subunit beta precursor - Bos taurus (Bovine) - FSHB gene Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. Indicus|evm.model.CM009505.1.676 Q5EA92 AL14E_BOVIN 100.000 0.992337 1.00385 ARL14EP - ARL14 effector protein - Bos taurus (Bovine) - ARL14EP gene Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. Indicus|evm.model.CM009505.1.677 Q5REB1 MPPD2_PONAB 100.000 0.99322 1.0034 MPPED2 - Metallophosphoesterase MPPED2 - Pongo abelii (Sumatran orangutan) - MPPED2 gene Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system. Indicus|evm.model.CM009505.1.678 M0R2J8 DCDC1_HUMAN 78.559 0.991047 0.626472 DCDC1 - Doublecortin domain-containing protein 1 - Homo sapiens (Human) - DCDC1 gene Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412). Indicus|evm.model.CM009505.1.679 Q5R893 H2B1_PONAB 92.857 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009505.1.680 M0R2J8 DCDC1_HUMAN 83.578 0.957547 0.237801 DCDC1 - Doublecortin domain-containing protein 1 - Homo sapiens (Human) - DCDC1 gene Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412). Indicus|evm.model.CM009505.1.681 Q0VBY7 DJC24_BOVIN 83.784 0.659574 1.26174 DNAJC24 - DnaJ homolog subfamily C member 24 - Bos taurus (Bovine) - DNAJC24 gene Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) (By similarity). Indicus|evm.model.CM009505.1.682 Q96LU5 IMP1L_HUMAN 92.169 0.988024 1.00602 IMMP1L - Mitochondrial inner membrane protease subunit 1 - Homo sapiens (Human) - IMMP1L gene Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. Indicus|evm.model.CM009505.1.684 Q2TBH6 ELP4_BOVIN 100.000 0.995283 1.00236 ELP4 - Elongator complex protein 4 - Bos taurus (Bovine) - ELP4 gene Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Indicus|evm.model.CM009505.1.685 P47237 PAX6_CHICK 96.847 0.505721 2.02315 PAX6 - Paired box protein Pax-6 - Gallus gallus (Chicken) - PAX6 gene May be a transcription factor with important functions in eye and nasal development. Indicus|evm.model.CM009505.1.686 Q15293 RCN1_HUMAN 95.565 0.925094 0.806647 RCN1 - Reticulocalbin-1 precursor - Homo sapiens (Human) - RCN1 gene May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Indicus|evm.model.CM009505.1.688 P49953 WT1_SMIMA 96.653 0.775244 1.28452 WT1 - Wilms tumor protein homolog - Sminthopsis macroura (Stripe-faced dunnart) - WT1 gene Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Indicus|evm.model.CM009505.1.689 Q7L2H7 EIF3M_HUMAN 100.000 0.994667 1.00267 EIF3M - Eukaryotic translation initiation factor 3 subunit M - Homo sapiens (Human) - EIF3M gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Indicus|evm.model.CM009505.1.690 Q6ZRK6 CCD73_HUMAN 69.926 0.998026 0.938832 CCDC73 - Coiled-coil domain-containing protein 73 - Homo sapiens (Human) - CCDC73 gene Indicus|evm.model.CM009505.1.691 Q9BZD6 TMG4_HUMAN 82.895 0.991266 1.01327 PRRG4 - Transmembrane gamma-carboxyglutamic acid protein 4 precursor - Homo sapiens (Human) - PRRG4 gene May control axon guidance across the CNS (PubMed:28859078). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (PubMed:28859078). Indicus|evm.model.CM009505.1.692 Q2KHR3 QSER1_HUMAN 89.534 0.998849 1.00173 QSER1 - Glutamine and serine-rich protein 1 - Homo sapiens (Human) - QSER1 gene Indicus|evm.model.CM009505.1.693 Q95JW3 DEPD7_MACFA 90.554 0.949219 1.01992 DEPDC7 - DEP domain-containing protein 7 - Macaca fascicularis (Crab-eating macaque) - DEPDC7 gene Indicus|evm.model.CM009505.1.695 Q9NUJ3 T11L1_HUMAN 86.640 0.996078 1.00196 TCP11L1 - T-complex protein 11-like protein 1 - Homo sapiens (Human) - TCP11L1 gene microtubule, signal transduction Indicus|evm.model.CM009505.1.696 Q12996 CSTF3_HUMAN 100.000 0.481848 0.845188 CSTF3 - Cleavage stimulation factor subunit 3 - Homo sapiens (Human) - CSTF3 gene One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. Indicus|evm.model.CM009505.1.697 Q9H422 HIPK3_HUMAN 94.572 0.995902 1.00412 HIPK3 - Homeodomain-interacting protein kinase 3 - Homo sapiens (Human) - HIPK3 gene Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Indicus|evm.model.CM009505.1.698 Q6ZVL6 K154L_HUMAN 79.506 0.887716 1.1271 KIAA1549L - UPF0606 protein KIAA1549L - Homo sapiens (Human) - KIAA1549L gene Indicus|evm.model.CM009505.1.699 A8WFF7 CK091_BOVIN 100.000 0.989011 0.943005 Uncharacterized protein C11orf91 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009505.1.700 O62680 CD59_PIG 61.157 0.967213 0.99187 CD59 - CD59 glycoprotein precursor - Sus scrofa (Pig) - CD59 gene Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. Indicus|evm.model.CM009505.1.701 A6H7H7 FBX3_BOVIN 100.000 0.995745 1.00213 FBXO3 - F-box only protein 3 - Bos taurus (Bovine) - FBXO3 gene Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). Indicus|evm.model.CM009505.1.703 Q1LZ94 RBTN2_BOVIN 100.000 0.987421 1.00633 LMO2 - Rhombotin-2 - Bos taurus (Bovine) - LMO2 gene Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. Indicus|evm.model.CM009505.1.704 Q1LZB6 CAPR1_BOVIN 100.000 0.997179 1.00141 CAPRIN1 - Caprin-1 - Bos taurus (Bovine) - CAPRIN1 gene May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs. Indicus|evm.model.CM009505.1.705 Q9H0A0 NAT10_HUMAN 96.589 0.998053 1.00195 NAT10 - RNA cytidine acetyltransferase - Homo sapiens (Human) - NAT10 gene RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Indicus|evm.model.CM009505.1.706 Q8N961 ABTB2_HUMAN 97.073 0.998051 1.00098 ABTB2 - Ankyrin repeat and BTB/POZ domain-containing protein 2 - Homo sapiens (Human) - ABTB2 gene May be involved in the initiation of hepatocyte growth. Indicus|evm.model.CM009505.1.707 P00432 CATA_BOVIN 100.000 0.996212 1.0019 CAT - Catalase - Bos taurus (Bovine) - CAT gene Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells. Indicus|evm.model.CM009505.1.708 Q58DT0 ELF5_BOVIN 100.000 0.992188 1.00392 ELF5 - ETS-related transcription factor Elf-5 - Bos taurus (Bovine) - ELF5 gene Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT] (By similarity). Indicus|evm.model.CM009505.1.709 Q32LN0 EHF_BOVIN 100.000 0.993355 1.00333 EHF - ETS homologous factor - Bos taurus (Bovine) - EHF gene Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity). Indicus|evm.model.CM009505.1.710 Q0VCJ2 MTNB_BOVIN 99.587 0.99177 1.00413 APIP - Methylthioribulose-1-phosphate dehydratase - Bos taurus (Bovine) - APIP gene Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. Indicus|evm.model.CM009505.1.711 P22439 ODPX_BOVIN 100.000 0.996016 1.002 PDHX - Pyruvate dehydrogenase protein X component precursor - Bos taurus (Bovine) - PDHX gene Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. Indicus|evm.model.CM009505.1.712 Q29423 CD44_BOVIN 96.739 0.739919 1.35519 CD44 - CD44 antigen precursor - Bos taurus (Bovine) - CD44 gene Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. Indicus|evm.model.CM009505.1.713 P43004 EAA2_HUMAN 97.007 0.967577 1.02091 SLC1A2 - Excitatory amino acid transporter 2 - Homo sapiens (Human) - SLC1A2 gene Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). Indicus|evm.model.CM009505.1.715 Q5E9P5 PAMR1_BOVIN 99.861 0.997226 1.00139 PAMR1 - Inactive serine protease PAMR1 precursor - Bos taurus (Bovine) - PAMR1 gene May play a role in regeneration of skeletal muscle. Indicus|evm.model.CM009505.1.716 Q86VR8 FJX1_HUMAN 95.848 0.966443 0.681922 FJX1 - Four-jointed box protein 1 precursor - Homo sapiens (Human) - FJX1 gene Acts as an inhibitor of dendrite extension and branching. Indicus|evm.model.CM009505.1.717 A6QQX5 TRI44_BOVIN 100.000 0.9941 1.00296 TRIM44 - Tripartite motif-containing protein 44 - Bos taurus (Bovine) - TRIM44 gene May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (By similarity). Is a negative regulator of PAX6 expression (By similarity). Indicus|evm.model.CM009505.1.718 Q86YD5 LRAD3_HUMAN 97.872 0.849741 1.11884 LDLRAD3 - Low-density lipoprotein receptor class A domain-containing protein 3 precursor - Homo sapiens (Human) - LDLRAD3 gene May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. Indicus|evm.model.CM009505.1.719 Q2TBN5 COMD9_BOVIN 99.495 0.98995 1.00505 COMMD9 - COMM domain-containing protein 9 - Bos taurus (Bovine) - COMMD9 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits. Indicus|evm.model.CM009505.1.720 Q5E9R0 PRR5L_BOVIN 99.728 0.99458 1.00272 PRR5L - Proline-rich protein 5-like - Bos taurus (Bovine) - PRR5L gene Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration. Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress. Indicus|evm.model.CM009505.1.721 Q3ZCC3 TRAF6_BOVIN 100.000 0.996317 1.00185 TRAF6 - TNF receptor-associated factor 6 - Bos taurus (Bovine) - TRAF6 gene E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. Indicus|evm.model.CM009505.1.722 Q867B5 RAG1_PIG 92.330 0.941283 1.06136 RAG1 - V(D)J recombination-activating protein 1 - Sus scrofa (Pig) - RAG1 gene Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitination of KPNA1 (By similarity). Indicus|evm.model.CM009505.1.723 P34089 RAG2_RABIT 91.271 0.996212 1.0019 RAG2 - V(D)J recombination-activating protein 2 - Oryctolagus cuniculus (Rabbit) - RAG2 gene Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity). Indicus|evm.model.CM009505.1.724 Q3ZBP0 IFTAP_BOVIN 97.934 0.99177 1.00413 IFTAP - Intraflagellar transport-associated protein - Bos taurus (Bovine) - IFTAP gene Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. Indicus|evm.model.CM009505.1.727 O43313 ATMIN_HUMAN 66.524 0.985075 0.488457 ATMIN - ATM interactor - Homo sapiens (Human) - ATMIN gene Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. Indicus|evm.model.CM009505.1.729 Q9HCJ2 LRC4C_HUMAN 99.688 0.99688 1.00156 LRRC4C - Leucine-rich repeat-containing protein 4C precursor - Homo sapiens (Human) - LRRC4C gene May promote neurite outgrowth of developing thalamic neurons. Indicus|evm.model.CM009505.1.730 Q0III0 MSD3_BOVIN 100.000 0.992754 1.00364 MSANTD3 - Myb/SANT-like DNA-binding domain-containing protein 3 - Bos taurus (Bovine) - MSANTD3 gene Indicus|evm.model.CM009505.1.731 Q14129 DGCR6_HUMAN 95.402 0.527607 0.740909 DGCR6 - Protein DGCR6 - Homo sapiens (Human) - DGCR6 gene May play a role in neural crest cell migration into the third and fourth pharyngeal pouches. Indicus|evm.model.CM009505.1.733 Q9BZZ5 API5_HUMAN 98.603 0.992063 0.961832 API5 - Apoptosis inhibitor 5 - Homo sapiens (Human) - API5 gene Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Indicus|evm.model.CM009505.1.734 B5DEL3 TTC17_RAT 93.990 0.981148 1.01836 Ttc17 - Tetratricopeptide repeat protein 17 - Rattus norvegicus (Rat) - Ttc17 gene Plays a role in primary ciliogenesis by modulating actin polymerization. Indicus|evm.model.CM009505.1.736 Q32L00 ALKB3_BOVIN 99.650 0.993031 1.0035 ALKBH3 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 - Bos taurus (Bovine) - ALKBH3 gene Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron. Indicus|evm.model.CM009505.1.737 Q3UPL5 CK096_MOUSE 95.283 0.846774 0.497992 Ag2 - Uncharacterized protein C11orf96 homolog - Mus musculus (Mouse) - Ag2 gene Indicus|evm.model.CM009505.1.738 Q4AC99 1A1L2_HUMAN 67.145 0.963605 1.01585 ACCSL - Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 - Homo sapiens (Human) - ACCSL gene Indicus|evm.model.CM009505.1.739 Q5E9H2 1A1L1_BOVIN 99.602 0.927778 1.0757 ACCS - 1-aminocyclopropane-1-carboxylate synthase-like protein 1 - Bos taurus (Bovine) - ACCS gene Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine. Indicus|evm.model.CM009505.1.740 O77783 EXT2_BOVIN 99.582 0.903023 1.10585 EXT2 - Exostosin-2 - Bos taurus (Bovine) - EXT2 gene Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. Indicus|evm.model.CM009505.1.741 Q4LAL6 ALX4_BOVIN 99.351 0.894737 0.43073 ALX4 - Homeobox protein aristaless-like 4 - Bos taurus (Bovine) - ALX4 gene Transcription factor involved in skull and limb development. Indicus|evm.model.CM009505.1.743 P27701 CD82_HUMAN 76.493 0.992565 1.00749 CD82 - CD82 antigen - Homo sapiens (Human) - CD82 gene Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Indicus|evm.model.CM009505.1.744 Q58CY8 TSN18_BOVIN 89.823 0.882114 0.987952 TSPAN18 - Tetraspanin-18 - Bos taurus (Bovine) - TSPAN18 gene integral component of plasma membrane Indicus|evm.model.CM009505.1.746 Q58CY8 TSN18_BOVIN 97.674 0.254545 0.662651 TSPAN18 - Tetraspanin-18 - Bos taurus (Bovine) - TSPAN18 gene integral component of plasma membrane Indicus|evm.model.CM009505.1.748 A2AGX3 PRD11_MOUSE 74.699 0.480469 0.906195 Prdm11 - PR domain-containing protein 11 - Mus musculus (Mouse) - Prdm11 gene May be involved in transcription regulation. Indicus|evm.model.CM009505.1.749 Q9NQV5 PRD11_HUMAN 90.580 0.270403 1.99022 PRDM11 - PR domain-containing protein 11 - Homo sapiens (Human) - PRDM11 gene May be involved in transcription regulation. Indicus|evm.model.CM009505.1.750 Q7L8C5 SYT13_HUMAN 92.254 0.995316 1.00235 SYT13 - Synaptotagmin-13 - Homo sapiens (Human) - SYT13 gene May be involved in transport vesicle docking to the plasma membrane. Indicus|evm.model.CM009505.1.752 O43916 CHST1_HUMAN 97.810 0.995146 1.00243 CHST1 - Carbohydrate sulfotransferase 1 - Homo sapiens (Human) - CHST1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Indicus|evm.model.CM009505.1.754 A6QM03 FUCT1_BOVIN 100.000 0.994521 1.00275 SLC35C1 - GDP-fucose transporter 1 - Bos taurus (Bovine) - SLC35C1 gene Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. Indicus|evm.model.CM009505.1.755 Q49AN0 CRY2_HUMAN 96.421 0.669492 1.19393 CRY2 - Cryptochrome-2 - Homo sapiens (Human) - CRY2 gene Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of NAMPT (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Represses the transcriptional activity of NR1I2 (By similarity). Indicus|evm.model.CM009505.1.756 Q9UQF2 JIP1_HUMAN 93.539 0.997187 1 MAPK8IP1 - C-Jun-amino-terminal kinase-interacting protein 1 - Homo sapiens (Human) - MAPK8IP1 gene The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. Indicus|evm.model.CM009505.1.757 A5PK62 CK094_BOVIN 100.000 0.98 1.0101 Uncharacterized protein C11orf94 homolog precursor - Bos taurus (Bovine) Indicus|evm.model.CM009505.1.758 Q2KII7 PEX16_BOVIN 100.000 0.993921 1.00305 PEX16 - Peroxisomal membrane protein PEX16 - Bos taurus (Bovine) - PEX16 gene Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity). Indicus|evm.model.CM009505.1.759 Q8N3Y3 LARG2_HUMAN 88.923 0.946763 0.963939 LARGE2 - LARGE xylosyl- and glucuronyltransferase 2 - Homo sapiens (Human) - LARGE2 gene Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Has a higher activity toward alpha-dystroglycan than LARGE. Indicus|evm.model.CM009505.1.760 Q96BD5 PF21A_HUMAN 97.222 0.997072 1.00441 PHF21A - PHD finger protein 21A - Homo sapiens (Human) - PHF21A gene Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. Indicus|evm.model.CM009505.1.761 Q96BA8 CR3L1_HUMAN 93.846 0.996161 1.00385 CREB3L1 - Cyclic AMP-responsive element-binding protein 3-like protein 1 - Homo sapiens (Human) - CREB3L1 gene Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401). Indicus|evm.model.CM009505.1.762 Q13574 DGKZ_HUMAN 89.766 0.712222 0.969828 DGKZ - Diacylglycerol kinase zeta - Homo sapiens (Human) - DGKZ gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). Indicus|evm.model.CM009505.1.763 P21741 MK_HUMAN 93.750 0.830065 1.06993 MDK - Midkine precursor - Homo sapiens (Human) - MDK gene Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:18469519, PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:24458438, PubMed:15466886, PubMed:12084985, PubMed:10772929). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:12084985, PubMed:10212223). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:10683378, PubMed:24458438, PubMed:22323540, PubMed:12084985, PubMed:15466886, PubMed:10772929). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity). Indicus|evm.model.CM009505.1.764 P08173 ACM4_HUMAN 96.258 0.995842 1.00418 CHRM4 - Muscarinic acetylcholine receptor M4 - Homo sapiens (Human) - CHRM4 gene The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. Indicus|evm.model.CM009505.1.765 A2AH22 AMRA1_MOUSE 96.875 0.211093 0.929231 Ambra1 - Activating molecule in BECN1-regulated autophagy protein 1 - Mus musculus (Mouse) - Ambra1 gene Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. Indicus|evm.model.CM009505.1.766 Q17QR8 HARB1_BOVIN 100.000 0.994286 1.00287 HARBI1 - Putative nuclease HARBI1 - Bos taurus (Bovine) - HARBI1 gene Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity (By similarity). Indicus|evm.model.CM009505.1.767 Q08DY8 ATG13_BOVIN 98.868 0.479129 1.14792 ATG13 - Autophagy-related protein 13 - Bos taurus (Bovine) - ATG13 gene Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. Indicus|evm.model.CM009505.1.768 Q07960 RHG01_HUMAN 95.444 0.876 1.13895 ARHGAP1 - Rho GTPase-activating protein 1 - Homo sapiens (Human) - ARHGAP1 gene GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate. Indicus|evm.model.CM009505.1.769 Q9H9D4 ZN408_HUMAN 77.514 0.984722 1 ZNF408 - Zinc finger protein 408 - Homo sapiens (Human) - ZNF408 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009505.1.770 P00735 THRB_BOVIN 99.840 0.996805 1.0016 F2 - Prothrombin precursor - Bos taurus (Bovine) - F2 gene Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). Indicus|evm.model.CM009505.1.771 Q14008 CKAP5_HUMAN 96.112 0.999016 1.00049 CKAP5 - Cytoskeleton-associated protein 5 - Homo sapiens (Human) - CKAP5 gene Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). Indicus|evm.model.CM009505.1.772 O75096 LRP4_HUMAN 97.617 0.991071 0.999475 LRP4 - Low-density lipoprotein receptor-related protein 4 precursor - Homo sapiens (Human) - LRP4 gene Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity). Indicus|evm.model.CM009505.1.773 A6NHA9 O4C46_HUMAN 70.130 0.965409 1.02913 OR4C46 - Olfactory receptor 4C46 - Homo sapiens (Human) - OR4C46 gene Odorant receptor. Indicus|evm.model.CM009505.1.774 Q32KQ7 CK049_BOVIN 99.636 0.825301 1.0184 UPF0705 protein C11orf49 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009505.1.775 A1L520 ARFG2_BOVIN 100.000 0.996161 1.00192 ARFGAP2 - ADP-ribosylation factor GTPase-activating protein 2 - Bos taurus (Bovine) - ARFGAP2 gene GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). Indicus|evm.model.CM009505.1.776 Q9UKS6 PACN3_HUMAN 94.811 0.995261 0.995283 PACSIN3 - Protein kinase C and casein kinase substrate in neurons protein 3 - Homo sapiens (Human) - PACSIN3 gene Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). Indicus|evm.model.CM009505.1.777 Q0VBY8 DDB2_BOVIN 99.765 0.995316 1.00235 DDB2 - DNA damage-binding protein 2 - Bos taurus (Bovine) - DDB2 gene Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR. Indicus|evm.model.CM009505.1.778 Q0P5F0 PPAL_BOVIN 100.000 0.995283 1.00236 ACP2 - Lysosomal acid phosphatase precursor - Bos taurus (Bovine) - ACP2 gene lysosome, acid phosphatase activity, phosphatase activity, dephosphorylation, lysosome organization Indicus|evm.model.CM009505.1.779 Q5E9B6 NR1H3_BOVIN 100.000 0.995536 1.00224 NR1H3 - Oxysterols receptor LXR-alpha - Bos taurus (Bovine) - NR1H3 gene Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Indicus|evm.model.CM009505.1.780 O08873 MADD_RAT 91.464 0.998737 0.988764 Madd - MAP kinase-activating death domain protein - Rattus norvegicus (Rat) - Madd gene Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:9020086). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (By similarity). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (PubMed:9020086). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in upregulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (By similarity). May link TNFRSF1A with MAP kinase activation (By similarity). May be involved in the regulation of TNFA-induced apoptosis (By similarity). Indicus|evm.model.CM009505.1.781 Q14896 MYPC3_HUMAN 89.490 0.998425 0.99686 MYBPC3 - Myosin-binding protein C, cardiac-type - Homo sapiens (Human) - MYBPC3 gene Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Indicus|evm.model.CM009505.1.782 Q6PKU1 SPI1_PIG 95.203 0.99262 1.0037 SPI1 - Transcription factor PU.1 - Sus scrofa (Pig) - SPI1 gene Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). Indicus|evm.model.CM009505.1.783 Q96H72 S39AD_HUMAN 88.441 0.994521 0.983827 SLC39A13 - Zinc transporter ZIP13 - Homo sapiens (Human) - SLC39A13 gene Acts as a zinc-influx transporter. Indicus|evm.model.CM009505.1.784 P17980 PRS6A_HUMAN 99.317 0.52518 1.89977 PSMC3 - 26S proteasome regulatory subunit 6A - Homo sapiens (Human) - PSMC3 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Indicus|evm.model.CM009505.1.786 Q92879 CELF1_HUMAN 98.765 0.94358 1.05761 CELF1 - CUGBP Elav-like family member 1 - Homo sapiens (Human) - CELF1 gene RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). Indicus|evm.model.CM009505.1.788 Q66GT5 PTPM1_MOUSE 78.846 0.836066 0.316062 Ptpmt1 - Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 precursor - Mus musculus (Mouse) - Ptpmt1 gene Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (PubMed:21641550, PubMed:21730175). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (PubMed:21641550). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (By similarity). Indicus|evm.model.CM009505.1.789 Q5R4S6 KBTB4_PONAB 99.228 0.960967 1.03861 KBTBD4 - Kelch repeat and BTB domain-containing protein 4 - Pongo abelii (Sumatran orangutan) - KBTBD4 gene Indicus|evm.model.CM009505.1.790 P23709 NDUS3_BOVIN 100.000 0.876 0.93985 NDUFS3 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor - Bos taurus (Bovine) - NDUFS3 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:18721790, PubMed:10852722). Essential for the catalytic activity and assembly of complex I (By similarity). Indicus|evm.model.CM009505.1.791 Q6P0A1 F180B_HUMAN 85.246 0.90099 1.10383 FAM180B - Protein FAM180B precursor - Homo sapiens (Human) - FAM180B gene Indicus|evm.model.CM009505.1.792 Q9BXJ3 C1QT4_HUMAN 87.755 0.695652 0.209726 C1QTNF4 - Complement C1q tumor necrosis factor-related protein 4 precursor - Homo sapiens (Human) - C1QTNF4 gene May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity). Indicus|evm.model.CM009505.1.793 Q9N285 MTCH2_BOVIN 88.047 0.994186 1.13531 MTCH2 - Mitochondrial carrier homolog 2 - Bos taurus (Bovine) - MTCH2 gene The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity). Indicus|evm.model.CM009505.1.794 Q8CDK2 CBPC2_MOUSE 65.979 0.463942 0.482599 Agbl2 - Cytosolic carboxypeptidase 2 - Mus musculus (Mouse) - Agbl2 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. Indicus|evm.model.CM009505.1.795 Q8N3X1 FNBP4_HUMAN 90.361 0.45392 1.4297 FNBP4 - Formin-binding protein 4 - Homo sapiens (Human) - FNBP4 gene nuclear speck Indicus|evm.model.CM009505.1.796 Q12769 NU160_HUMAN 94.887 0.962843 0.862117 NUP160 - Nuclear pore complex protein Nup160 - Homo sapiens (Human) - NUP160 gene Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport. Indicus|evm.model.CM009505.1.797 Q12913 PTPRJ_HUMAN 94.550 0.327078 0.836948 PTPRJ - Receptor-type tyrosine-protein phosphatase eta precursor - Homo sapiens (Human) - PTPRJ gene Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. Indicus|evm.model.CM009505.1.798 Q64455 PTPRJ_MOUSE 75.000 0.419014 0.229402 Ptprj - Receptor-type tyrosine-protein phosphatase eta precursor - Mus musculus (Mouse) - Ptprj gene Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. May be involved in the mechanism of contact inhibition of cell growth. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. Indicus|evm.model.CM009505.1.802 Q8NGB2 OR4C5_HUMAN 73.600 0.976378 0.389571 OR4C5 - Olfactory receptor 4C5 - Homo sapiens (Human) - OR4C5 gene Odorant receptor. Indicus|evm.model.CM009505.1.803 Q8NH37 OR4C3_HUMAN 66.667 0.928571 0.370861 OR4C3 - Olfactory receptor 4C3 - Homo sapiens (Human) - OR4C3 gene Odorant receptor. Indicus|evm.model.CM009505.1.804 Q8NGL7 OR4P4_HUMAN 72.289 0.953488 0.275641 OR4P4 - Olfactory receptor 4P4 - Homo sapiens (Human) - OR4P4 gene Odorant receptor. Indicus|evm.model.CM009505.1.805 Q0VAX3 FS2P1_MOUSE 71.546 0.983539 0.997947 Fads2b - Fatty acid desaturase 2-like protein FADS2B - Mus musculus (Mouse) - Fads2b gene Indicus|evm.model.CM009505.1.806 Q8NGG4 OR8H1_HUMAN 81.560 0.992908 0.453376 OR8H1 - Olfactory receptor 8H1 - Homo sapiens (Human) - OR8H1 gene Odorant receptor. Indicus|evm.model.CM009505.1.808 Q7TR96 O1013_MOUSE 70.330 0.983696 0.603279 Olfr1013 - Olfactory receptor 1013 - Mus musculus (Mouse) - Olfr1013 gene Odorant receptor. Indicus|evm.model.CM009505.1.809 P0C617 O5AL1_HUMAN 74.302 0.994413 0.544073 OR5AL1 - Olfactory receptor 5AL1 - Homo sapiens (Human) - OR5AL1 gene Odorant receptor. Indicus|evm.model.CM009505.1.811 Q8VGS1 O1038_MOUSE 96.835 0.993671 0.495298 Olfr1038 - Olfactory receptor 1038 - Mus musculus (Mouse) - Olfr1038 gene Potential odorant receptor. Indicus|evm.model.CM009505.1.813 Q8VFK7 O1020_MOUSE 85.475 0.946809 0.59306 Olfr1020 - Olfactory receptor 1020 - Mus musculus (Mouse) - Olfr1020 gene Potential odorant receptor. Indicus|evm.model.CM009505.1.814 P0C7N8 OR9G9_HUMAN 76.727 0.992754 0.904918 OR9G9 - Olfactory receptor 9G9 - Homo sapiens (Human) - OR9G9 gene Odorant receptor. Indicus|evm.model.CM009505.1.816 Q8NH87 OR9G1_HUMAN 74.603 0.939394 0.432787 OR9G1 - Olfactory receptor 9G1 - Homo sapiens (Human) - OR9G1 gene Odorant receptor. Indicus|evm.model.CM009505.1.817 Q0VAX3 FS2P1_MOUSE 73.306 0.987654 0.997947 Fads2b - Fatty acid desaturase 2-like protein FADS2B - Mus musculus (Mouse) - Fads2b gene Indicus|evm.model.CM009505.1.818 Q4KLL3 LRC55_RAT 89.262 0.951923 1.04698 Lrrc55 - Leucine-rich repeat-containing protein 55 precursor - Rattus norvegicus (Rat) - Lrrc55 gene Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity). Indicus|evm.model.CM009505.1.819 O97666 APJ_MACMU 75.500 0.995012 1.05526 APLNR - Apelin receptor - Macaca mulatta (Rhesus macaque) - APLNR gene Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure. Indicus|evm.model.CM009505.1.820 Q9C0C2 TB182_HUMAN 68.441 0.290141 1.0266 TNKS1BP1 - 182 kDa tankyrase-1-binding protein - Homo sapiens (Human) - TNKS1BP1 gene actin cytoskeleton, adherens junction, CCR4-NOT complex, cytoplasm, cytosol, heterochromatin, nucleus, plasma membrane, ankyrin repeat binding, cadherin binding Indicus|evm.model.CM009505.1.821 Q08945 SSRP1_HUMAN 99.295 0.997183 1.00141 SSRP1 - FACT complex subunit SSRP1 - Homo sapiens (Human) - SSRP1 gene Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. Indicus|evm.model.CM009505.1.822 P49654 P2RX3_RAT 91.940 0.994975 1.00252 P2rx3 - P2X purinoceptor 3 - Rattus norvegicus (Rat) - P2rx3 gene Receptor for ATP that acts as a ligand-gated cation channel (PubMed:7566120, PubMed:7566119). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity). Indicus|evm.model.CM009505.1.823 Q63189 PRG2_RAT 61.333 0.675799 0.964758 Prg2 - Bone marrow proteoglycan precursor - Rattus norvegicus (Rat) - Prg2 gene Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity). Indicus|evm.model.CM009505.1.824 Q9Y2Y8 PRG3_HUMAN 56.338 0.936073 0.973333 PRG3 - Proteoglycan 3 precursor - Homo sapiens (Human) - PRG3 gene Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. Indicus|evm.model.CM009505.1.825 Q9Y2Y8 PRG3_HUMAN 54.930 0.936652 0.982222 PRG3 - Proteoglycan 3 precursor - Homo sapiens (Human) - PRG3 gene Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. Indicus|evm.model.CM009505.1.826 Q9Y2Y8 PRG3_HUMAN 56.808 0.936652 0.982222 PRG3 - Proteoglycan 3 precursor - Homo sapiens (Human) - PRG3 gene Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. Indicus|evm.model.CM009505.1.827 Q1JPD8 S43A3_BOVIN 99.387 0.995918 1.00204 SLC43A3 - Solute carrier family 43 member 3 - Bos taurus (Bovine) - SLC43A3 gene Putative transporter. Indicus|evm.model.CM009505.1.828 Q86UN3 R4RL2_HUMAN 93.590 0.663818 0.835714 RTN4RL2 - Reticulon-4 receptor-like 2 precursor - Homo sapiens (Human) - RTN4RL2 gene Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Indicus|evm.model.CM009505.1.829 O75387 LAT3_HUMAN 81.522 0.916667 0.34347 SLC43A1 - Large neutral amino acids transporter small subunit 3 - Homo sapiens (Human) - SLC43A1 gene Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. Indicus|evm.model.CM009505.1.830 Q8BSM7 LAT3_MOUSE 80.756 0.973064 0.526596 Slc43a1 - Large neutral amino acids transporter small subunit 3 - Mus musculus (Mouse) - Slc43a1 gene Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine (By similarity). Indicus|evm.model.CM009505.1.831 Q5RCR3 RL4_PONAB 79.310 0.982456 0.266979 RPL4 - 60S ribosomal protein L4 - Pongo abelii (Sumatran orangutan) - RPL4 gene Indicus|evm.model.CM009505.1.832 Q2NKR1 TIM10_BOVIN 100.000 0.978022 1.01111 TIMM10 - Mitochondrial import inner membrane translocase subunit Tim10 - Bos taurus (Bovine) - TIMM10 gene Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Indicus|evm.model.CM009505.1.833 A8MU46 SMTL1_HUMAN 60.040 0.995604 0.921053 SMTNL1 - Smoothelin-like protein 1 - Homo sapiens (Human) - SMTNL1 gene Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity). Indicus|evm.model.CM009505.1.834 A5PJC4 UB2L6_BOVIN 100.000 0.987013 1.00654 UBE2L6 - Ubiquitin/ISG15-conjugating enzyme E2 L6 - Bos taurus (Bovine) - UBE2L6 gene Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Indicus|evm.model.CM009505.1.835 P50448 F12AI_BOVIN 98.932 0.995736 1.00214 Factor XIIa inhibitor precursor - Bos taurus (Bovine) Indicus|evm.model.CM009505.1.837 Q5XID5 YPEL4_RAT 98.765 0.733945 0.858268 Ypel4 - Protein yippee-like 4 - Rattus norvegicus (Rat) - Ypel4 gene Indicus|evm.model.CM009505.1.838 A2VE01 CLP1_BOVIN 100.000 0.995305 1.00235 CLP1 - Polyribonucleotide 5'-hydroxyl-kinase Clp1 - Bos taurus (Bovine) - CLP1 gene Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity). Indicus|evm.model.CM009505.1.839 P30999 CTND1_MOUSE 95.513 0.965696 1.02559 Ctnnd1 - Catenin delta-1 - Mus musculus (Mouse) - Ctnnd1 gene Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Indicus|evm.model.CM009505.1.840 E1BLT8 ZDHC5_BOVIN 97.619 0.997203 1.0014 ZDHHC5 - Palmitoyltransferase ZDHHC5 - Bos taurus (Bovine) - ZDHHC5 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Palmitoylates the G-protein coupled receptor SSTR5 and for FLOT2. Indicus|evm.model.CM009505.1.841 A0JLT2 MED19_HUMAN 95.082 0.927481 1.07377 MED19 - Mediator of RNA polymerase II transcription subunit 19 - Homo sapiens (Human) - MED19 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Indicus|evm.model.CM009505.1.842 Q2TBU2 TMX2_BOVIN 100.000 0.993266 1.00338 TMX2 - Thioredoxin-related transmembrane protein 2 precursor - Bos taurus (Bovine) - TMX2 gene Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain. Indicus|evm.model.CM009505.1.843 Q8IZQ5 SELH_HUMAN 71.545 0.981818 0.901639 SELENOH - Selenoprotein H - Homo sapiens (Human) - SELENOH gene May be involved in a redox-related process. Indicus|evm.model.CM009505.1.844 B2RXH4 BTBDI_HUMAN 75.758 0.914783 0.807584 BTBD18 - BTB/POZ domain-containing protein 18 - Homo sapiens (Human) - BTBD18 gene Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene. Indicus|evm.model.CM009505.1.845 Q96R08 OR5BC_HUMAN 53.659 0.276018 1.40764 OR5B12 - Olfactory receptor 5B12 - Homo sapiens (Human) - OR5B12 gene Odorant receptor. Indicus|evm.model.CM009505.1.849 Q8NGF6 O10W1_HUMAN 71.429 0.522727 0.432787 OR10W1 - Olfactory receptor 10W1 - Homo sapiens (Human) - OR10W1 gene Odorant receptor. Indicus|evm.model.CM009505.1.853 Q96R09 OR5B2_HUMAN 80.399 0.967742 1.00324 OR5B2 - Olfactory receptor 5B2 - Homo sapiens (Human) - OR5B2 gene Odorant receptor. Indicus|evm.model.CM009505.1.855 Q96R08 OR5BC_HUMAN 73.973 0.993174 0.933121 OR5B12 - Olfactory receptor 5B12 - Homo sapiens (Human) - OR5B12 gene Odorant receptor. Indicus|evm.model.CM009505.1.857 Q9N261 LPXN_RABIT 86.327 0.75 1.28497 LPXN - Leupaxin - Oryctolagus cuniculus (Rabbit) - LPXN gene Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling (By similarity). Indicus|evm.model.CM009505.1.858 Q96JP5 ZFP91_HUMAN 92.220 0.891616 0.857895 ZFP91 - E3 ubiquitin-protein ligase ZFP91 - Homo sapiens (Human) - ZFP91 gene Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. Indicus|evm.model.CM009505.1.859 O02732 CNTF_PIG 78.000 0.99 1 CNTF - Ciliary neurotrophic factor - Sus scrofa (Pig) - CNTF gene CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity). Indicus|evm.model.CM009505.1.861 Q6IB77 GLYAT_HUMAN 70.847 0.993243 1 GLYAT - Glycine N-acyltransferase - Homo sapiens (Human) - GLYAT gene Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. Indicus|evm.model.CM009505.1.862 O77512 GLYAL_BOVIN 65.649 0.640394 0.688136 Glycine N-phenylacetyltransferase - Bos taurus (Bovine) Indicus|evm.model.CM009505.1.863 Q2KIR7 GLYAT_BOVIN 99.661 0.945338 1.05424 GLYAT - Glycine N-acyltransferase - Bos taurus (Bovine) - GLYAT gene Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. Indicus|evm.model.CM009505.1.864 O77512 GLYAL_BOVIN 94.576 0.992933 0.959322 Glycine N-phenylacetyltransferase - Bos taurus (Bovine) Indicus|evm.model.CM009505.1.865 Q6SJ93 F111B_HUMAN 63.208 0.995924 1.00272 FAM111B - Serine protease FAM111B - Homo sapiens (Human) - FAM111B gene Serine protease. Indicus|evm.model.CM009505.1.866 Q96PZ2 F111A_HUMAN 47.674 0.440415 0.315876 FAM111A - Serine protease FAM111A - Homo sapiens (Human) - FAM111A gene Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:32165630). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:32165630). Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors (PubMed:32165630). Required for PCNA loading on replication sites (PubMed:24561620). Promotes S-phase entry and DNA synthesis (PubMed:24561620). Indicus|evm.model.CM009505.1.867 Q9Y2E6 DTX4_HUMAN 96.805 0.681223 0.739903 DTX4 - E3 ubiquitin-protein ligase DTX4 - Homo sapiens (Human) - DTX4 gene Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. Indicus|evm.model.CM009505.1.868 Q2KJC3 MPEG1_BOVIN 99.861 0.997214 1.00139 MPEG1 - Macrophage-expressed gene 1 protein precursor - Bos taurus (Bovine) - MPEG1 gene Plays a key role in the innate immune response following bacterial infection by polymerizing and inserting into the bacterial surface to form pores (By similarity). By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (By similarity). Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (By similarity). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity). Indicus|evm.model.CM009505.1.869 Q8VFV4 O1440_MOUSE 72.472 0.988827 0.568254 Olfr1440 - Olfactory receptor 1440 - Mus musculus (Mouse) - Olfr1440 gene Odorant receptor involved in the detection of muscone. Indicus|evm.model.CM009505.1.870 P58180 OR4D2_HUMAN 69.333 0.601626 0.400651 OR4D2 - Olfactory receptor 4D2 - Homo sapiens (Human) - OR4D2 gene Odorant receptor. Indicus|evm.model.CM009505.1.871 Q9NP64 NO40_HUMAN 94.419 0.930435 0.954357 ZCCHC17 - Nucleolar protein of 40 kDa - Homo sapiens (Human) - ZCCHC17 gene identical protein binding, RNA binding, RNA stabilization Indicus|evm.model.CM009505.1.872 P16258 OSBP1_RABIT 96.373 0.123393 1.92336 OSBP - Oxysterol-binding protein 1 - Oryctolagus cuniculus (Rabbit) - OSBP gene Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:18165705). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (By similarity). Regulates cholesterol efflux by decreasing ABCA1 stability (By similarity). Indicus|evm.model.CM009505.1.874 Q08849 STX3_RAT 96.441 0.734908 1.31834 Stx3 - Syntaxin-3 - Rattus norvegicus (Rat) - Stx3 gene Potentially involved in docking of synaptic vesicles at presynaptic active zones. Indicus|evm.model.CM009505.1.875 Q3T0J3 RM16_BOVIN 99.602 0.992063 1.00398 MRPL16 - 39S ribosomal protein L16, mitochondrial precursor - Bos taurus (Bovine) - MRPL16 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, rRNA binding, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009505.1.876 P27352 IF_HUMAN 78.177 0.995215 1.0024 CBLIF - Cobalamin binding intrinsic factor precursor - Homo sapiens (Human) - CBLIF gene Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis. Indicus|evm.model.CM009505.1.877 P20061 TCO1_HUMAN 61.894 0.995327 0.988453 TCN1 - Transcobalamin-1 precursor - Homo sapiens (Human) - TCN1 gene Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach. Indicus|evm.model.CM009505.1.878 Q2Q0J1 OOSP1_BOVIN 97.674 0.345013 2.27607 OOSP1 - Oocyte-secreted protein 1 precursor - Bos taurus (Bovine) - OOSP1 gene May be involved in cell differentiation. Indicus|evm.model.CM009505.1.879 Q9GZW8 MS4A7_HUMAN 68.687 0.295181 2.76667 MS4A7 - Membrane-spanning 4-domains subfamily A member 7 - Homo sapiens (Human) - MS4A7 gene May be involved in signal transduction as a component of a multimeric receptor complex. Indicus|evm.model.CM009505.1.881 Q9H3V2 MS4A5_HUMAN 62.626 0.960976 1.025 MS4A5 - Membrane-spanning 4-domains subfamily A member 5 - Homo sapiens (Human) - MS4A5 gene May be involved in signal transduction as a component of a multimeric receptor complex. Indicus|evm.model.CM009505.1.882 Q3C2E2 CD20_CANLF 66.447 0.992908 0.949495 MS4A1 - B-lymphocyte antigen CD20 - Canis lupus familiaris (Dog) - MS4A1 gene B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. Indicus|evm.model.CM009505.1.883 Q2YDM3 M4A13_BOVIN 99.346 0.858757 1.15686 MS4A13 - Membrane-spanning 4-domains subfamily A member 13 - Bos taurus (Bovine) - MS4A13 gene May be involved in signal transduction as a component of a multimeric receptor complex. Indicus|evm.model.CM009505.1.886 P42695 CNDD3_HUMAN 64.069 0.998651 0.989987 NCAPD3 - Condensin-2 complex subunit D3 - Homo sapiens (Human) - NCAPD3 gene Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Indicus|evm.model.CM009505.1.887 Q8C0E2 VP26B_MOUSE 95.536 0.994065 1.00298 Vps26b - Vacuolar protein sorting-associated protein 26B - Mus musculus (Mouse) - Vps26b gene Acts as component of the retromer cargo-selective complex (CSC) (PubMed:21040701, PubMed:21920005). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (By similarity). May be involved in retrograde transport of SORT1 but not of IGF2R (PubMed:21040701). Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (PubMed:25136126). Indicus|evm.model.CM009505.1.889 Q9P016 THYN1_HUMAN 77.778 0.991071 0.995556 THYN1 - Thymocyte nuclear protein 1 - Homo sapiens (Human) - THYN1 gene Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Indicus|evm.model.CM009505.1.890 Q0NXR6 ACAD8_BOVIN 100.000 0.995204 1.0024 ACAD8 - Isobutyryl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACAD8 gene Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA. Indicus|evm.model.CM009505.1.891 Q8NCI6 GLBL3_HUMAN 68.114 0.456837 2.00459 GLB1L3 - Beta-galactosidase-1-like protein 3 - Homo sapiens (Human) - GLB1L3 gene vacuole, beta-galactosidase activity Indicus|evm.model.CM009505.1.892 Q8IW92 GLBL2_HUMAN 74.961 0.995283 1 GLB1L2 - Beta-galactosidase-1-like protein 2 precursor - Homo sapiens (Human) - GLB1L2 gene vacuole, beta-galactosidase activity Indicus|evm.model.CM009505.1.893 O35789 B3GA1_RAT 87.425 0.95509 1 B3gat1 - Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 - Rattus norvegicus (Rat) - B3gat1 gene Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. Indicus|evm.model.CM009506.1.1 Q8NGG7 OR8A1_HUMAN 56.897 0.678571 0.257669 OR8A1 - Olfactory receptor 8A1 - Homo sapiens (Human) - OR8A1 gene Odorant receptor. Indicus|evm.model.CM009506.1.2 Q95155 OLF2_CANLF 80.064 0.95092 1.04823 Olfactory receptor-like protein OLF2 - Canis lupus familiaris (Dog) Indicus|evm.model.CM009506.1.3 Q5EA86 TM183_BOVIN 100.000 0.994695 1.00266 TMEM183 - Transmembrane protein 183 - Bos taurus (Bovine) - TMEM183 gene Indicus|evm.model.CM009506.1.5 O75335 LIPA4_HUMAN 86.326 0.998325 1.00759 PPFIA4 - Liprin-alpha-4 - Homo sapiens (Human) - PPFIA4 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity). Indicus|evm.model.CM009506.1.6 Q7YS81 MYOG_BOVIN 99.554 0.991111 1.00446 MYOG - Myogenin - Bos taurus (Bovine) - MYOG gene Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity). Indicus|evm.model.CM009506.1.7 P28190 AA1R_BOVIN 99.693 0.993884 1.00307 ADORA1 - Adenosine receptor A1 - Bos taurus (Bovine) - ADORA1 gene Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Indicus|evm.model.CM009506.1.8 Q13203 MYBPH_HUMAN 80.448 0.995935 1.03145 MYBPH - Myosin-binding protein H - Homo sapiens (Human) - MYBPH gene Binds to myosin; probably involved in interaction with thick myofilaments in the A-band. Indicus|evm.model.CM009506.1.9 P30922 CH3L1_BOVIN 98.433 0.97449 1.0235 CHI3L1 - Chitinase-3-like protein 1 precursor - Bos taurus (Bovine) - CHI3L1 gene Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity). Indicus|evm.model.CM009506.1.10 Q13231 CHIT1_HUMAN 77.778 0.622378 0.306867 CHIT1 - Chitotriosidase-1 precursor - Homo sapiens (Human) - CHIT1 gene Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. Indicus|evm.model.CM009506.1.11 Q4R7Y2 RL10_MACFA 79.085 0.820652 0.859813 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009506.1.12 Q04211 BTG2_MOUSE 94.000 0.986755 0.955696 Btg2 - Protein BTG2 - Mus musculus (Mouse) - Btg2 gene Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity). Indicus|evm.model.CM009506.1.13 P13605 FMOD_BOVIN 100.000 0.899281 1.10904 FMOD - Fibromodulin precursor - Bos taurus (Bovine) - FMOD gene Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). Indicus|evm.model.CM009506.1.14 Q9GKN8 PRELP_BOVIN 99.738 0.994764 1.00262 PRELP - Prolargin precursor - Bos taurus (Bovine) - PRELP gene May anchor basement membranes to the underlying connective tissue. Indicus|evm.model.CM009506.1.15 P58874 OPT_BOVIN 99.377 0.993789 1.00312 OPTC - Opticin precursor - Bos taurus (Bovine) - OPTC gene Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (PubMed:12951322, PubMed:10636917). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). Indicus|evm.model.CM009506.1.17 D3K0R6 AT2B4_BOVIN 100.000 0.702946 1.3778 ATP2B4 - Plasma membrane calcium-transporting ATPase 4 - Bos taurus (Bovine) - ATP2B4 gene Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (By similarity). By regulating sperm cells calcium homeostasis, may play a role in sperm motility (By similarity). Indicus|evm.model.CM009506.1.18 P86452 ZBED6_HUMAN 90.224 0.997961 1.00204 ZBED6 - Zinc finger BED domain-containing protein 6 - Homo sapiens (Human) - ZBED6 gene Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (By similarity). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (By similarity). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (By similarity). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (By similarity). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (By similarity). Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816). Binds to the CDH2 gene and may directly repress CDH2 transcription (By similarity). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (By similarity). May also play a role in embryonic beta cell differentiation (By similarity). May play a role in insulin sensitivity and glucose clearance (By similarity). Indicus|evm.model.CM009506.1.19 O75152 ZC11A_HUMAN 83.599 0.997552 1.00864 ZC3H11A - Zinc finger CCCH domain-containing protein 11A - Homo sapiens (Human) - ZC3H11A gene RNA-binding protein that interacts with purine-rich sequences and is involved in nuclear mRNA export; probably mediated by association with the TREX complex. Indicus|evm.model.CM009506.1.20 P62305 RUXE_MOUSE 100.000 0.978495 1.01087 Snrpe - Small nuclear ribonucleoprotein E - Mus musculus (Mouse) - Snrpe gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. Indicus|evm.model.CM009506.1.21 Q9UN79 SOX13_HUMAN 88.320 0.996805 1.00643 SOX13 - Transcription factor SOX-13 - Homo sapiens (Human) - SOX13 gene Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). Indicus|evm.model.CM009506.1.22 Q9NVF9 EKI2_HUMAN 91.135 0.992933 0.733161 ETNK2 - Ethanolamine kinase 2 - Homo sapiens (Human) - ETNK2 gene Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity). Indicus|evm.model.CM009506.1.23 P52115 RENI_SHEEP 96.010 0.994987 0.9975 REN - Renin precursor - Ovis aries (Sheep) - REN gene Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Indicus|evm.model.CM009506.1.24 Q2NKV8 GOT1A_BOVIN 100.000 0.404762 2.22727 GOLT1A - Vesicle transport protein GOT1A - Bos taurus (Bovine) - GOLT1A gene May be involved in fusion of ER-derived transport vesicles with the Golgi complex. Indicus|evm.model.CM009506.1.25 Q9Y2H5 PKHA6_HUMAN 86.351 0.998182 1.04962 PLEKHA6 - Pleckstrin homology domain-containing family A member 6 - Homo sapiens (Human) - PLEKHA6 gene Indicus|evm.model.CM009506.1.27 Q5SWA1 PR15B_HUMAN 73.773 0.997139 0.980365 PPP1R15B - Protein phosphatase 1 regulatory subunit 15B - Homo sapiens (Human) - PPP1R15B gene Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. Indicus|evm.model.CM009506.1.28 O00750 P3C2B_HUMAN 93.635 0.998777 1.00061 PIK3C2B - Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta - Homo sapiens (Human) - PIK3C2B gene Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:9830063, PubMed:11533253). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). Indicus|evm.model.CM009506.1.30 Q2HJ21 MDM4_BOVIN 99.796 0.995935 1.00204 MDM4 - Protein Mdm4 - Bos taurus (Bovine) - MDM4 gene Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity). Indicus|evm.model.CM009506.1.32 O75325 LRRN2_HUMAN 93.268 0.997195 1 LRRN2 - Leucine-rich repeat neuronal protein 2 precursor - Homo sapiens (Human) - LRRN2 gene extracellular matrix, extracellular space, signaling receptor activity, cell adhesion, signal transduction Indicus|evm.model.CM009506.1.33 Q810U3 NFASC_MOUSE 94.579 0.995958 0.997581 Nfasc - Neurofascin precursor - Mus musculus (Mouse) - Nfasc gene Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Indicus|evm.model.CM009506.1.36 Q02246 CNTN2_HUMAN 91.250 0.998079 1.00096 CNTN2 - Contactin-2 precursor - Homo sapiens (Human) - CNTN2 gene In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion. Indicus|evm.model.CM009506.1.37 Q0VCB1 TMM81_BOVIN 99.275 0.99278 1.00362 TMEM81 - Transmembrane protein 81 precursor - Bos taurus (Bovine) - TMEM81 gene Indicus|evm.model.CM009506.1.38 Q15291 RBBP5_HUMAN 100.000 0.996289 1.00186 RBBP5 - Retinoblastoma-binding protein 5 - Homo sapiens (Human) - RBBP5 gene In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:22266653, PubMed:21220120). Indicus|evm.model.CM009506.1.39 Q4TVR5 DUSTY_BOVIN 99.892 0.997847 1.00108 DSTYK - Dual serine/threonine and tyrosine protein kinase - Bos taurus (Bovine) - DSTYK gene Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. Indicus|evm.model.CM009506.1.40 O75069 TMCC2_HUMAN 90.141 0.186667 0.528914 TMCC2 - Transmembrane and coiled-coil domains protein 2 - Homo sapiens (Human) - TMCC2 gene May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. Indicus|evm.model.CM009506.1.41 O75069 TMCC2_HUMAN 93.750 0.968619 0.674189 TMCC2 - Transmembrane and coiled-coil domains protein 2 - Homo sapiens (Human) - TMCC2 gene May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. Indicus|evm.model.CM009506.1.42 Q9H093 NUAK2_HUMAN 83.566 0.996899 1.02707 NUAK2 - NUAK family SNF1-like kinase 2 - Homo sapiens (Human) - NUAK2 gene Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1. Indicus|evm.model.CM009506.1.43 Q8IYD2 KLD8A_HUMAN 94.737 0.941909 0.688571 KLHDC8A - Kelch domain-containing protein 8A - Homo sapiens (Human) - KLHDC8A gene Indicus|evm.model.CM009506.1.44 Q8IYD2 KLD8A_HUMAN 96.000 0.939394 0.377143 KLHDC8A - Kelch domain-containing protein 8A - Homo sapiens (Human) - KLHDC8A gene Indicus|evm.model.CM009506.1.45 Q68G75 LEMD1_HUMAN 79.412 0.515385 0.718232 LEMD1 - LEM domain-containing protein 1 - Homo sapiens (Human) - LEMD1 gene Indicus|evm.model.CM009506.1.46 Q5RD01 CDK18_PONAB 91.949 0.995763 0.995781 CDK18 - Cyclin-dependent kinase 18 - Pongo abelii (Sumatran orangutan) - CDK18 gene May play a role in signal transduction cascades in terminally differentiated cells. Indicus|evm.model.CM009506.1.47 Q5RCN7 MFD4A_PONAB 87.029 0.977226 0.939689 MFSD4A - Major facilitator superfamily domain-containing protein 4A - Pongo abelii (Sumatran orangutan) - MFSD4A gene Indicus|evm.model.CM009506.1.48 P28324 ELK4_HUMAN 90.046 0.995381 1.00464 ELK4 - ETS domain-containing protein Elk-4 - Homo sapiens (Human) - ELK4 gene Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. Indicus|evm.model.CM009506.1.49 Q96JT2 S45A3_HUMAN 89.130 0.994555 0.996383 SLC45A3 - Solute carrier family 45 member 3 - Homo sapiens (Human) - SLC45A3 gene membrane, plasma membrane, sucrose:proton symporter activity, hexose transmembrane transport, positive regulation of fatty acid biosynthetic process, positive regulation of glucose metabolic process, regulation of oligodendrocyte differentiation, sucrose transport Indicus|evm.model.CM009506.1.50 Q29S11 NUCKS_BOVIN 99.578 0.944 1.02881 NUCKS1 - Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 - Bos taurus (Bovine) - NUCKS1 gene Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1. Indicus|evm.model.CM009506.1.51 Q91YQ1 RAB7L_MOUSE 94.608 0.990196 1 Rab29 - Ras-related protein Rab-7L1 - Mus musculus (Mouse) - Rab29 gene The small GTPases Rab are key regulators in vesicle trafficking (By similarity). Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact central nervous system (CNS) (By similarity). Indicus|evm.model.CM009506.1.52 Q5R839 S41A1_PONAB 96.498 0.996117 1.0039 SLC41A1 - Solute carrier family 41 member 1 - Pongo abelii (Sumatran orangutan) - SLC41A1 gene Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (By similarity). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). Indicus|evm.model.CM009506.1.53 Q2T9M7 P20D1_BOVIN 99.205 0.996032 1.00199 PM20D1 - N-fatty-acyl-amino acid synthase/hydrolase PM20D1 precursor - Bos taurus (Bovine) - PM20D1 gene Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles. Indicus|evm.model.CM009506.1.54 Q7LBE3 S26A9_HUMAN 89.820 0.941392 1.0354 SLC26A9 - Solute carrier family 26 member 9 - Homo sapiens (Human) - SLC26A9 gene DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport (PubMed:11834742). Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion (PubMed:15800055). May prefer chloride anions and mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane (By similarity). Indicus|evm.model.CM009506.1.55 Q08DE8 RAB7B_BOVIN 99.248 0.505747 1.305 RAB7B - Ras-related protein Rab-7b - Bos taurus (Bovine) - RAB7B gene Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway (By similarity). Indicus|evm.model.CM009506.1.56 P14091 CATE_HUMAN 68.750 0.424658 0.184343 CTSE - Cathepsin E precursor - Homo sapiens (Human) - CTSE gene May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Indicus|evm.model.CM009506.1.58 Q6ZWK4 RHEX_HUMAN 65.476 0.988166 0.982558 RHEX - Regulator of hemoglobinization and erythroid cell expansion protein - Homo sapiens (Human) - RHEX gene Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation (PubMed:25092874). Indicus|evm.model.CM009506.1.59 P47901 V1BR_HUMAN 79.812 0.995294 1.00236 AVPR1B - Vasopressin V1b receptor - Homo sapiens (Human) - AVPR1B gene Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Indicus|evm.model.CM009506.1.60 P0DMP2 SRG2B_HUMAN 98.894 0.420709 2.34061 SRGAP2B - SLIT-ROBO Rho GTPase-activating protein 2B - Homo sapiens (Human) - SRGAP2B gene May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2. Indicus|evm.model.CM009506.1.61 Q14164 IKKE_HUMAN 88.162 0.997218 1.00419 IKBKE - Inhibitor of nuclear factor kappa-B kinase subunit epsilon - Homo sapiens (Human) - IKBKE gene Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. Indicus|evm.model.CM009506.1.62 Q8WWW0 RASF5_HUMAN 90.977 0.506692 1.2512 RASSF5 - Ras association domain-containing protein 5 - Homo sapiens (Human) - RASSF5 gene Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. Indicus|evm.model.CM009506.1.63 Q58CR3 EIF2D_BOVIN 99.827 0.871795 1.14508 EIF2D - Eukaryotic translation initiation factor 2D - Bos taurus (Bovine) - EIF2D gene Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity). Indicus|evm.model.CM009506.1.64 O43781 DYRK3_HUMAN 92.857 0.996599 1 DYRK3 - Dual specificity tyrosine-phosphorylation-regulated kinase 3 - Homo sapiens (Human) - DYRK3 gene Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:9748265, PubMed:29634919). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). Indicus|evm.model.CM009506.1.65 P49139 MAPK2_RABIT 90.476 0.303704 0.368852 MAPKAPK2 - MAP kinase-activated protein kinase 2 - Oryctolagus cuniculus (Rabbit) - MAPKAPK2 gene Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (By similarity). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress following ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (By similarity). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Indicus|evm.model.CM009506.1.66 P49137 MAPK2_HUMAN 99.674 0.993506 0.77 MAPKAPK2 - MAP kinase-activated protein kinase 2 - Homo sapiens (Human) - MAPKAPK2 gene Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Indicus|evm.model.CM009506.1.67 P43480 IL10_BOVIN 100.000 0.972222 1.01124 IL10 - Interleukin-10 precursor - Bos taurus (Bovine) - IL10 gene Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity). Indicus|evm.model.CM009506.1.68 Q9UHD0 IL19_HUMAN 77.397 0.905063 0.892655 IL19 - Interleukin-19 precursor - Homo sapiens (Human) - IL19 gene May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). Indicus|evm.model.CM009506.1.69 Q9NYY1 IL20_HUMAN 76.159 0.806452 1.05682 IL20 - Interleukin-20 precursor - Homo sapiens (Human) - IL20 gene Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. Indicus|evm.model.CM009506.1.70 P81265 PIGR_BOVIN 99.207 0.997361 1.00132 PIGR - Polymeric immunoglobulin receptor precursor - Bos taurus (Bovine) - PIGR gene Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Indicus|evm.model.CM009506.1.71 Q8WWV6 FCAMR_HUMAN 50.507 0.935039 0.954887 FCAMR - High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor precursor - Homo sapiens (Human) - FCAMR gene Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM. Indicus|evm.model.CM009506.1.72 O60667 FAIM3_HUMAN 73.171 0.0775194 1.32308 FCMR - Fas apoptotic inhibitory molecule 3 precursor - Homo sapiens (Human) - FCMR gene May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. Indicus|evm.model.CM009506.1.73 Q13007 IL24_HUMAN 61.850 0.944751 0.878641 IL24 - Interleukin-24 precursor - Homo sapiens (Human) - IL24 gene Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. Indicus|evm.model.CM009506.1.74 A5D7K1 SARG_BOVIN 99.665 0.996656 1.00168 SARG - Specifically androgen-regulated gene protein - Bos taurus (Bovine) - SARG gene Putative androgen-specific receptor. Indicus|evm.model.CM009506.1.75 Q05B57 OTU1_BOVIN 100.000 0.994269 1.00287 YOD1 - Ubiquitin thioesterase OTU1 - Bos taurus (Bovine) - YOD1 gene Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation. Indicus|evm.model.CM009506.1.76 P26285 F262_BOVIN 99.812 0.996241 1.00188 PFKFB2 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 - Bos taurus (Bovine) - PFKFB2 gene Synthesis and degradation of fructose 2,6-bisphosphate. Indicus|evm.model.CM009506.1.77 Q28066 C4BPB_BOVIN 99.495 0.98995 1.00505 C4BPB - C4b-binding protein beta chain precursor - Bos taurus (Bovine) - C4BPB gene Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with serum amyloid P component. Indicus|evm.model.CM009506.1.78 Q28065 C4BPA_BOVIN 99.316 0.957377 1 C4BPA - C4b-binding protein alpha chain precursor - Bos taurus (Bovine) - C4BPA gene Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. Indicus|evm.model.CM009506.1.79 P04003 C4BPA_HUMAN 54.375 0.811224 0.328308 C4BPA - C4b-binding protein alpha chain precursor - Homo sapiens (Human) - C4BPA gene Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. Indicus|evm.model.CM009506.1.80 P08174 DAF_HUMAN 58.389 0.533333 1.45669 CD55 - Complement decay-accelerating factor precursor - Homo sapiens (Human) - CD55 gene This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). Indicus|evm.model.CM009506.1.81 P20023 CR2_HUMAN 64.813 0.738629 1.42594 CR2 - Complement receptor type 2 precursor - Homo sapiens (Human) - CR2 gene Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047). Indicus|evm.model.CM009506.1.82 Q28085 CFAH_BOVIN 82.203 0.820144 0.11246 CFH - Complement factor H precursor - Bos taurus (Bovine) - CFH gene Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. Indicus|evm.model.CM009506.1.83 Q28085 CFAH_BOVIN 86.156 0.873913 0.558252 CFH - Complement factor H precursor - Bos taurus (Bovine) - CFH gene Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. Indicus|evm.model.CM009506.1.84 Q5RC43 RFA2_PONAB 82.328 0.990868 0.811111 RPA2 - Replication protein A 32 kDa subunit - Pongo abelii (Sumatran orangutan) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Indicus|evm.model.CM009506.1.85 Q28085 CFAH_BOVIN 66.582 0.950122 0.665049 CFH - Complement factor H precursor - Bos taurus (Bovine) - CFH gene Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. Indicus|evm.model.CM009506.1.86 Q6UVM3 KCNT2_HUMAN 98.481 0.768257 0.904846 KCNT2 - Potassium channel subfamily T member 2 - Homo sapiens (Human) - KCNT2 gene Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600). Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497). Indicus|evm.model.CM009506.1.96 Q6U7Q0 ZN322_HUMAN 90.678 0.983193 0.29602 ZNF322 - Zinc finger protein 322 - Homo sapiens (Human) - ZNF322 gene Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). Indicus|evm.model.CM009506.1.99 A0JNC2 R3HD2_BOVIN 81.125 0.99458 0.746208 R3HDM2 - R3H domain-containing protein 2 - Bos taurus (Bovine) - R3HDM2 gene Indicus|evm.model.CM009506.1.100 Q6P9X4 TP4A2_RAT 63.830 0.94898 0.586826 Ptp4a2 - Protein tyrosine phosphatase type IVA 2 precursor - Rattus norvegicus (Rat) - Ptp4a2 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity). Indicus|evm.model.CM009506.1.101 P47832 RL26_CHICK 67.442 0.824176 0.710938 RPL26 - 60S ribosomal protein L26 - Gallus gallus (Chicken) - RPL26 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome, cytoplasmic translation, ribosomal large subunit biogenesis Indicus|evm.model.CM009506.1.102 P10103 HMGB1_BOVIN 98.605 0.990741 1.00465 HMGB1 - High mobility group protein B1 - Bos taurus (Bovine) - HMGB1 gene Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins (By similarity). Indicus|evm.model.CM009506.1.104 Q8JZM7 CDC73_MOUSE 93.548 0.99596 0.932203 Cdc73 - Parafibromin - Mus musculus (Mouse) - Cdc73 gene Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors (By similarity). Indicus|evm.model.CM009506.1.105 Q32L67 GLRX2_BOVIN 100.000 0.987342 1.00637 GLRX2 - Glutaredoxin-2, mitochondrial precursor - Bos taurus (Bovine) - GLRX2 gene Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release (By similarity). Indicus|evm.model.CM009506.1.106 P10155 RO60_HUMAN 95.911 0.996289 1.00186 RO60 - 60 kDa SS-A/Ro ribonucleoprotein - Homo sapiens (Human) - RO60 gene RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation (PubMed:18056422). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853). Indicus|evm.model.CM009506.1.107 Q06AT3 UCHL5_PIG 99.696 0.993939 1.00304 UCHL5 - Ubiquitin carboxyl-terminal hydrolase isozyme L5 - Sus scrofa (Pig) - UCHL5 gene Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). Indicus|evm.model.CM009506.1.108 Q0P5H5 RGS2_BOVIN 100.000 0.990566 1.00474 RGS2 - Regulator of G-protein signaling 2 - Bos taurus (Bovine) - RGS2 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity). Indicus|evm.model.CM009506.1.109 Q6RG78 RGS1_HORSE 92.347 0.928571 1.07143 RGS1 - Regulator of G-protein signaling 1 - Equus caballus (Horse) - RGS1 gene Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Indicus|evm.model.CM009506.1.110 Q2M5E4 RGS21_HUMAN 94.118 0.980392 0.335526 RGS21 - Regulator of G-protein signaling 21 - Homo sapiens (Human) - RGS21 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Indicus|evm.model.CM009506.1.111 Q2M5E4 RGS21_HUMAN 83.529 0.686957 0.756579 RGS21 - Regulator of G-protein signaling 21 - Homo sapiens (Human) - RGS21 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Indicus|evm.model.CM009506.1.112 Q9NS28 RGS18_HUMAN 74.894 0.990385 0.885106 RGS18 - Regulator of G-protein signaling 18 - Homo sapiens (Human) - RGS18 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha. Indicus|evm.model.CM009506.1.113 P61255 RL26_MOUSE 88.636 0.443299 0.668966 Rpl26 - 60S ribosomal protein L26 - Mus musculus (Mouse) - Rpl26 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009506.1.116 Q76B58 BRNP3_HUMAN 97.781 0.997392 1.00131 BRINP3 - BMP/retinoic acid-inducible neural-specific protein 3 precursor - Homo sapiens (Human) - BRINP3 gene Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development. Indicus|evm.model.CM009506.1.122 Q9Y597 KCTD3_HUMAN 96.701 0.997465 0.968098 KCTD3 - BTB/POZ domain-containing protein KCTD3 - Homo sapiens (Human) - KCTD3 gene Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. Indicus|evm.model.CM009506.1.123 Q8K3K1 USH2A_RAT 79.808 0.0927093 0.21678 Ush2a - Usherin precursor - Rattus norvegicus (Rat) - Ush2a gene Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Indicus|evm.model.CM009506.1.124 Q9Y343 SNX24_HUMAN 83.871 0.983871 0.733728 SNX24 - Sorting nexin-24 - Homo sapiens (Human) - SNX24 gene May be involved in several stages of intracellular trafficking. Indicus|evm.model.CM009506.1.125 O75445 USH2A_HUMAN 65.769 0.377941 0.261438 USH2A - Usherin precursor - Homo sapiens (Human) - USH2A gene Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Indicus|evm.model.CM009506.1.126 O75445 USH2A_HUMAN 78.713 0.702797 0.0549789 USH2A - Usherin precursor - Homo sapiens (Human) - USH2A gene Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Indicus|evm.model.CM009506.1.127 O75445 USH2A_HUMAN 76.389 0.842723 0.0818916 USH2A - Usherin precursor - Homo sapiens (Human) - USH2A gene Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Indicus|evm.model.CM009506.1.128 O75445 USH2A_HUMAN 86.730 0.843373 0.0478662 USH2A - Usherin precursor - Homo sapiens (Human) - USH2A gene Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Indicus|evm.model.CM009506.1.129 O75445 USH2A_HUMAN 76.959 0.824427 0.0503652 USH2A - Usherin precursor - Homo sapiens (Human) - USH2A gene Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Indicus|evm.model.CM009506.1.130 P62510 ERR3_RAT 100.000 0.995413 0.951965 Esrrg - Estrogen-related receptor gamma - Rattus norvegicus (Rat) - Esrrg gene Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle (By similarity). Indicus|evm.model.CM009506.1.131 Q9NW75 GPTC2_HUMAN 93.945 0.9125 1.06061 GPATCH2 - G patch domain-containing protein 2 - Homo sapiens (Human) - GPATCH2 gene Enhances the ATPase activity of DHX15 in vitro. Indicus|evm.model.CM009506.1.132 Q96L03 SPT17_HUMAN 82.320 0.99449 1.00554 SPATA17 - Spermatogenesis-associated protein 17 - Homo sapiens (Human) - SPATA17 gene calmodulin binding Indicus|evm.model.CM009506.1.133 Q5NVM9 HSP7C_PONAB 88.889 0.649635 0.212074 HSPA8 - Heat shock cognate 71 kDa protein - Pongo abelii (Sumatran orangutan) - HSPA8 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Interacts with VGF-derived peptide TLQP-21. Indicus|evm.model.CM009506.1.134 Q3T062 RRP15_BOVIN 100.000 0.925325 1.07692 RRP15 - RRP15-like protein - Bos taurus (Bovine) - RRP15 gene preribosome, large subunit precursor, maturation of 5.8S rRNA, maturation of LSU-rRNA Indicus|evm.model.CM009506.1.135 P21214 TGFB2_BOVIN 100.000 0.995181 1.00242 TGFB2 - Transforming growth factor beta-2 proprotein precursor - Bos taurus (Bovine) - TGFB2 gene Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Indicus|evm.model.CM009506.1.136 Q9NXK6 PAQR5_HUMAN 78.846 0.762963 0.409091 PAQR5 - Membrane progestin receptor gamma - Homo sapiens (Human) - PAQR5 gene Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). Indicus|evm.model.CM009506.1.137 Q5JUK9 PAGE3_HUMAN 50.526 0.783333 1.06195 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Indicus|evm.model.CM009506.1.138 Q5VWZ2 LYPL1_HUMAN 89.610 0.987124 0.983122 LYPLAL1 - Lysophospholipase-like protein 1 - Homo sapiens (Human) - LYPLAL1 gene Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. Indicus|evm.model.CM009506.1.140 Q6XR72 ZNT10_HUMAN 83.951 0.995893 1.00412 SLC30A10 - Zinc transporter 10 - Homo sapiens (Human) - SLC30A10 gene Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971, PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells (PubMed:22706290, PubMed:22427991, PubMed:26728129). Indicus|evm.model.CM009506.1.141 P07814 SYEP_HUMAN 92.526 0.998677 1 EPRS1 - Bifunctional glutamate/proline--tRNA ligase - Homo sapiens (Human) - EPRS1 gene Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (PubMed:1756734, PubMed:24100331, PubMed:23263184). The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it to the GAIT complex that binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin), suppressing their translation. Interferon-gamma can therefore redirect, in specific cells, the EPRS1 function from protein synthesis to translation inhibition (PubMed:15479637, PubMed:23071094). Also functions as an effector of the mTORC1 signaling pathway by promoting, through SLC27A1, the uptake of long-chain fatty acid by adipocytes. Thereby, it also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). Indicus|evm.model.CM009506.1.142 Q3ZCK3 BPNT1_BOVIN 95.356 0.96988 1.07792 BPNT1 - 3'(2'),5'-bisphosphate nucleotidase 1 - Bos taurus (Bovine) - BPNT1 gene Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6 (By similarity). Indicus|evm.model.CM009506.1.143 Q9NSE4 SYIM_HUMAN 89.667 0.997706 0.86166 IARS2 - Isoleucine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - IARS2 gene mitochondrial matrix, mitochondrion, isoleucine-tRNA ligase activity, isoleucyl-tRNA aminoacylation, mitochondrial translation, tRNA aminoacylation for protein translation Indicus|evm.model.CM009506.1.144 Q9H2M9 RBGPR_HUMAN 92.606 0.998564 1 RAB3GAP2 - Rab3 GTPase-activating protein non-catalytic subunit - Homo sapiens (Human) - RAB3GAP2 gene Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. Indicus|evm.model.CM009506.1.145 Q9P0L2 MARK1_HUMAN 97.044 0.992337 0.984906 MARK1 - Serine/threonine-protein kinase MARK1 - Homo sapiens (Human) - MARK1 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Indicus|evm.model.CM009506.1.146 Q9H7X2 CA115_HUMAN 75.000 0.985612 0.978873 C1orf115 - Uncharacterized protein C1orf115 - Homo sapiens (Human) - C1orf115 gene 9+0 non-motile cilium Indicus|evm.model.CM009506.1.147 Q1LZH1 MARC2_BOVIN 100.000 0.933775 0.89881 MTARC2 - Mitochondrial amidoxime reducing component 2 precursor - Bos taurus (Bovine) - MTARC2 gene Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. Indicus|evm.model.CM009506.1.148 Q5VT66 MARC1_HUMAN 85.757 0.991124 1.00297 MTARC1 - Mitochondrial amidoxime-reducing component 1 - Homo sapiens (Human) - MTARC1 gene Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045, PubMed:19053771). Indicus|evm.model.CM009506.1.149 A7MB54 HLX_BOVIN 100.000 0.995893 1.00206 HLX - H2.0-like homeobox protein - Bos taurus (Bovine) - HLX gene Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity). Indicus|evm.model.CM009506.1.151 Q58DW0 RL4_BOVIN 68.000 0.951923 0.246445 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Indicus|evm.model.CM009506.1.152 Q0IID7 DUS10_BOVIN 100.000 0.995859 1.00207 DUSP10 - Dual specificity protein phosphatase 10 - Bos taurus (Bovine) - DUSP10 gene Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Indicus|evm.model.CM009506.1.154 Q6UWX4 HIPL2_HUMAN 85.820 0.580172 1.60221 HHIPL2 - HHIP-like protein 2 precursor - Homo sapiens (Human) - HHIPL2 gene Indicus|evm.model.CM009506.1.155 Q0VC16 TGO1_BOVIN 96.070 0.998913 0.965879 MIA3 - Transport and Golgi organization protein 1 homolog precursor - Bos taurus (Bovine) - MIA3 gene Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES. Indicus|evm.model.CM009506.1.156 Q5RAV3 AIDA_PONAB 99.673 0.993485 1.00327 AIDA - Axin interactor, dorsalization-associated protein - Pongo abelii (Sumatran orangutan) - AIDA gene Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). Indicus|evm.model.CM009506.1.157 Q5RDD7 BROX_PONAB 96.594 0.864979 1.15328 BROX - BRO1 domain-containing protein BROX precursor - Pongo abelii (Sumatran orangutan) - BROX gene Indicus|evm.model.CM009506.1.158 A6PVY3 F177B_HUMAN 67.073 0.48503 1.05696 FAM177B - Protein FAM177B - Homo sapiens (Human) - FAM177B gene Indicus|evm.model.CM009506.1.159 Q13825 AUHM_HUMAN 71.951 0.955017 0.852507 AUH - Methylglutaconyl-CoA hydratase, mitochondrial precursor - Homo sapiens (Human) - AUH gene Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA (PubMed:11738050, PubMed:12434311, PubMed:12655555). Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Has very low enoyl-CoA hydratase activity (PubMed:7892223). Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs (PubMed:7892223). Indicus|evm.model.CM009506.1.160 Q96F81 DISP1_HUMAN 91.004 0.987742 1.01706 DISP1 - Protein dispatched homolog 1 - Homo sapiens (Human) - DISP1 gene Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). Indicus|evm.model.CM009506.1.161 O60602 TLR5_HUMAN 78.438 0.997672 1.00117 TLR5 - Toll-like receptor 5 precursor - Homo sapiens (Human) - TLR5 gene Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity). Indicus|evm.model.CM009506.1.162 Q5VX71 SUSD4_HUMAN 93.673 0.995927 1.00204 SUSD4 - Sushi domain-containing protein 4 precursor - Homo sapiens (Human) - SUSD4 gene Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. Indicus|evm.model.CM009506.1.163 Q8N715 CC185_HUMAN 60.220 0.996825 1.01124 CCDC185 - Coiled-coil domain-containing protein 185 - Homo sapiens (Human) - CCDC185 gene Indicus|evm.model.CM009506.1.164 Q78EJ9 CAN8_RAT 79.659 0.997015 0.953058 Capn8 - Calpain-8 - Rattus norvegicus (Rat) - Capn8 gene Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity). Indicus|evm.model.CM009506.1.165 Q27971 CAN2_BOVIN 100.000 0.997147 1.00143 CAPN2 - Calpain-2 catalytic subunit precursor - Bos taurus (Bovine) - CAPN2 gene Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. Indicus|evm.model.CM009506.1.166 Q13625 ASPP2_HUMAN 91.652 0.998225 0.999113 TP53BP2 - Apoptosis-stimulating of p53 protein 2 - Homo sapiens (Human) - TP53BP2 gene Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Indicus|evm.model.CM009506.1.167 Q2NL16 FBX28_BOVIN 100.000 0.99458 1.00272 FBXO28 - F-box only protein 28 - Bos taurus (Bovine) - FBXO28 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Indicus|evm.model.CM009506.1.168 Q3ZBY7 DEGS1_BOVIN 90.000 0.329545 0.272446 DEGS1 - Sphingolipid delta(4)-desaturase DES1 - Bos taurus (Bovine) - DEGS1 gene Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity). Catalyzes the equilibrium isomerization of retinols (By similarity). Indicus|evm.model.CM009506.1.169 Q3ZBY7 DEGS1_BOVIN 100.000 0.993056 0.891641 DEGS1 - Sphingolipid delta(4)-desaturase DES1 - Bos taurus (Bovine) - DEGS1 gene Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity). Catalyzes the equilibrium isomerization of retinols (By similarity). Indicus|evm.model.CM009506.1.170 O15381 NVL_HUMAN 89.663 0.997677 1.00584 NVL - Nuclear valosin-containing protein-like - Homo sapiens (Human) - NVL gene Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111). Indicus|evm.model.CM009506.1.171 Q3T126 CNIH4_BOVIN 100.000 0.985714 1.00719 CNIH4 - Protein cornichon homolog 4 - Bos taurus (Bovine) - CNIH4 gene Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. Indicus|evm.model.CM009506.1.172 Q9H7D7 WDR26_HUMAN 99.396 0.996983 1.00303 WDR26 - WD repeat-containing protein 26 - Homo sapiens (Human) - WDR26 gene G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity). Indicus|evm.model.CM009506.1.173 Q58DT3 ZDHC4_BOVIN 66.176 0.983193 0.346939 ZDHHC4 - Palmitoyltransferase ZDHHC4 - Bos taurus (Bovine) - ZDHHC4 gene Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2. Indicus|evm.model.CM009506.1.174 Q401C0 CNIH2_CHICK 68.293 0.253165 0.9875 CNIH2 - Protein cornichon homolog 2 - Gallus gallus (Chicken) - CNIH2 gene Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs) (By similarity). Plays an important role in the proper development of cranial nerves by facilitating the secretion of HBEGF. Indicus|evm.model.CM009506.1.175 D0Q0Y7 CNIH3_RAT 95.000 0.265306 0.91875 Cnih3 - Protein cornichon homolog 3 - Rattus norvegicus (Rat) - Cnih3 gene Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Indicus|evm.model.CM009506.1.176 Q6ZWS4 CNIH3_MOUSE 96.629 0.423077 1.3 Cnih3 - Protein cornichon homolog 3 - Mus musculus (Mouse) - Cnih3 gene Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization (By similarity). Indicus|evm.model.CM009506.1.179 Q9C0G6 DYH6_HUMAN 35.179 0.900762 1.04209 DNAH6 - Dynein axonemal heavy chain 6 - Homo sapiens (Human) - DNAH6 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Indicus|evm.model.CM009506.1.180 Q14739 LBR_HUMAN 86.473 0.943683 1.06829 LBR - Delta(14)-sterol reductase LBR - Homo sapiens (Human) - LBR gene Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:9630650, PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). Indicus|evm.model.CM009506.1.181 Q8N8S7 ENAH_HUMAN 88.344 0.385298 1.33503 ENAH - Protein enabled homolog - Homo sapiens (Human) - ENAH gene Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). Indicus|evm.model.CM009506.1.182 P21262 SRP09_CANLF 98.837 0.977011 1.01163 SRP9 - Signal recognition particle 9 kDa protein - Canis lupus familiaris (Dog) - SRP9 gene Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. Indicus|evm.model.CM009506.1.183 P79381 HYEP_PIG 87.445 0.995575 0.995595 EPHX1 - Epoxide hydrolase 1 - Sus scrofa (Pig) - EPHX1 gene Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity). Indicus|evm.model.CM009506.1.184 A0A452G813 CSCL1_CAPHI 95.392 0.997506 0.998755 TMEM63A - CSC1-like protein 1 - Capra hircus (Goat) - TMEM63A gene Acts as an osmosensitive calcium-permeable cation channel (By similarity). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (By similarity). Indicus|evm.model.CM009506.1.185 O00292 LFTY2_HUMAN 82.834 0.994565 1.00546 LEFTY2 - Left-right determination factor 2 precursor - Homo sapiens (Human) - LEFTY2 gene Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Indicus|evm.model.CM009506.1.186 Q17QJ7 P5CR2_BOVIN 100.000 0.993769 1.00313 PYCR2 - Pyrroline-5-carboxylate reductase 2 - Bos taurus (Bovine) - PYCR2 gene Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity). Indicus|evm.model.CM009506.1.187 O00292 LFTY2_HUMAN 81.471 0.994565 1.00546 LEFTY2 - Left-right determination factor 2 precursor - Homo sapiens (Human) - LEFTY2 gene Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Indicus|evm.model.CM009506.1.188 Q64368 DAZL_MOUSE 71.277 0.853211 0.365772 Dazl - Deleted in azoospermia-like - Mus musculus (Mouse) - Dazl gene RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts. Indicus|evm.model.CM009506.1.189 Q6IQ49 SDE2_HUMAN 77.802 0.995595 1.00665 SDE2 - Replication stress response regulator SDE2 precursor - Homo sapiens (Human) - SDE2 gene Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S-phase progression (PubMed:27906959). Indicus|evm.model.CM009506.1.191 P84246 H33_RABIT 100.000 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009506.1.192 Q9H3P7 GCP60_HUMAN 97.159 0.996219 1.00189 ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). Indicus|evm.model.CM009506.1.193 Q9H2W2 MIXL1_HUMAN 74.576 0.987395 1.02586 MIXL1 - Homeobox protein MIXL1 - Homo sapiens (Human) - MIXL1 gene Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). Indicus|evm.model.CM009506.1.194 Q5TKA1 LIN9_HUMAN 99.262 0.9678 1.03137 LIN9 - Protein lin-9 homolog - Homo sapiens (Human) - LIN9 gene Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. Indicus|evm.model.CM009506.1.195 P18493 PARP1_BOVIN 99.213 0.998033 1.00098 PARP1 - Poly [ADP-ribose] polymerase 1 - Bos taurus (Bovine) - PARP1 gene Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate, serine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1. Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP1 active site. Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1. PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation. Mediates the poly(ADP-ribosyl)ation of a number of proteins, including itself, APLF and CHFR. In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Acts as a regulator of transcription: positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and EEF1A1. Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Indicus|evm.model.CM009506.1.196 P10854 H2B1M_MOUSE 95.522 0.970588 0.539683 H2bc14 - Histone H2B type 1-M - Mus musculus (Mouse) - H2bc14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009506.1.197 Q69YW2 STUM_HUMAN 95.745 0.985507 0.978723 STUM - Protein stum homolog - Homo sapiens (Human) - STUM gene Indicus|evm.model.CM009506.1.198 Q1RMG8 RPAC2_BOVIN 99.248 0.985075 1.00752 POLR1D - DNA-directed RNA polymerases I and III subunit RPAC2 - Bos taurus (Bovine) - POLR1D gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. Indicus|evm.model.CM009506.1.199 P27987 IP3KB_HUMAN 76.335 0.997875 0.994715 ITPKB - Inositol-trisphosphate 3-kinase B - Homo sapiens (Human) - ITPKB gene cytoplasm, cytosol, nucleus, inositol hexakisphosphate kinase activity, inositol-1,4,5-trisphosphate 3-kinase activity, kinase activity, cellular response to calcium ion, inositol phosphate biosynthetic process, inositol phosphate metabolic process, inositol trisphosphate metabolic process Indicus|evm.model.CM009506.1.200 Q9XT96 PSN2_BOVIN 100.000 0.995556 1.00223 PSEN2 - Presenilin-2 - Bos taurus (Bovine) - PSEN2 gene Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. Indicus|evm.model.CM009506.1.201 Q29RI0 COQ8A_BOVIN 95.387 0.997028 1.03858 COQ8A - Atypical kinase COQ8A, mitochondrial precursor - Bos taurus (Bovine) - COQ8A gene Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP. Indicus|evm.model.CM009506.1.202 Q5VT25 MRCKA_HUMAN 97.229 0.998837 0.993072 CDC42BPA - Serine/threonine-protein kinase MRCK alpha - Homo sapiens (Human) - CDC42BPA gene Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). Indicus|evm.model.CM009506.1.203 P62334 PRS10_MOUSE 99.115 0.982456 0.293059 Psmc6 - 26S proteasome regulatory subunit 10B - Mus musculus (Mouse) - Psmc6 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Indicus|evm.model.CM009506.1.204 Q2KIW6 PRS10_BOVIN 98.462 0.955556 0.347044 PSMC6 - 26S proteasome regulatory subunit 10B - Bos taurus (Bovine) - PSMC6 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Indicus|evm.model.CM009506.1.205 Q2KIW6 PRS10_BOVIN 96.226 0.867769 0.311054 PSMC6 - 26S proteasome regulatory subunit 10B - Bos taurus (Bovine) - PSMC6 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Indicus|evm.model.CM009506.1.206 Q8WYP5 ELYS_HUMAN 80.570 0.692167 1.44793 AHCTF1 - Protein ELYS - Homo sapiens (Human) - AHCTF1 gene Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. Indicus|evm.model.CM009506.1.207 Q3T067 SCPDL_BOVIN 99.767 0.995349 1.00233 SCCPDH - Saccharopine dehydrogenase-like oxidoreductase - Bos taurus (Bovine) - SCCPDH gene Indicus|evm.model.CM009506.1.209 Q3SZB8 H3CL_BOVIN 99.265 0.985401 1.00735 Histone H3.3C-like - Bos taurus (Bovine) Indicus|evm.model.CM009506.1.210 Q45FY6 HPRT_PIG 72.477 0.959391 0.90367 HPRT1 - Hypoxanthine-guanine phosphoribosyltransferase - Sus scrofa (Pig) - HPRT1 gene Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). Indicus|evm.model.CM009506.1.211 Q6PJW8 CNST_HUMAN 82.852 0.799378 0.886897 CNST - Consortin - Homo sapiens (Human) - CNST gene Required for targeting of connexins to the plasma membrane. Indicus|evm.model.CM009506.1.213 Q32LD4 TFB2M_BOVIN 100.000 0.994937 1.00254 TFB2M - Dimethyladenosine transferase 2, mitochondrial precursor - Bos taurus (Bovine) - TFB2M gene S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity. Indicus|evm.model.CM009506.1.214 Q9H7B4 SMYD3_HUMAN 69.444 0.682692 0.242991 SMYD3 - Histone-lysine N-methyltransferase SMYD3 - Homo sapiens (Human) - SMYD3 gene Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609). Indicus|evm.model.CM009506.1.215 Q9H7B4 SMYD3_HUMAN 92.308 0.31875 0.373832 SMYD3 - Histone-lysine N-methyltransferase SMYD3 - Homo sapiens (Human) - SMYD3 gene Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609). Indicus|evm.model.CM009506.1.218 Q2KJY2 KI26B_HUMAN 98.519 0.57265 0.111006 KIF26B - Kinesin-like protein KIF26B - Homo sapiens (Human) - KIF26B gene Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). Indicus|evm.model.CM009506.1.219 Q5VUJ9 DRC8_HUMAN 92.241 0.69697 0.613383 EFCAB2 - Dynein regulatory complex protein 8 - Homo sapiens (Human) - EFCAB2 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Indicus|evm.model.CM009506.1.220 Q00839 HNRPU_HUMAN 98.573 0.981767 0.864242 HNRNPU - Heterogeneous nuclear ribonucleoprotein U - Homo sapiens (Human) - HNRNPU gene DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:8174554, PubMed:28622508). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:8174554, PubMed:9353307, PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Contributes also to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:7509195, PubMed:1324173, PubMed:9204873, PubMed:9405365, PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:28622508). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). Indicus|evm.model.CM009506.1.221 Q9BSY9 DESI2_HUMAN 98.969 0.989744 1.00515 DESI2 - Deubiquitinase DESI2 - Homo sapiens (Human) - DESI2 gene Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520). Indicus|evm.model.CM009506.1.222 Q5SY80 CTSRE_HUMAN 69.333 0.0844749 0.921136 CATSPERE - Cation channel sperm-associated protein subunit epsilon precursor - Homo sapiens (Human) - CATSPERE gene Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Indicus|evm.model.CM009506.1.225 A7MBG0 PURA2_BOVIN 99.781 0.995624 1.00219 ADSS2 - Adenylosuccinate synthetase isozyme 2 - Bos taurus (Bovine) - ADSS2 gene Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Indicus|evm.model.CM009506.1.226 Q32L72 CA100_BOVIN 99.275 0.985612 1.00725 Uncharacterized protein C1orf100 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009506.1.227 A0JN76 ZBT18_BOVIN 100.000 0.844408 1.18199 ZBTB18 - Zinc finger and BTB domain-containing protein 18 - Bos taurus (Bovine) - ZBTB18 gene Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus (By similarity). Indicus|evm.model.CM009506.1.228 Q9WUA6 AKT3_MOUSE 100.000 0.993007 0.298539 Akt3 - RAC-gamma serine/threonine-protein kinase - Mus musculus (Mouse) - Akt3 gene AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Indicus|evm.model.CM009506.1.229 Q86SQ7 SDCG8_HUMAN 81.513 0.942971 1.0575 SDCCAG8 - Serologically defined colon cancer antigen 8 - Homo sapiens (Human) - SDCCAG8 gene Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). Indicus|evm.model.CM009506.1.230 Q5SW79 CE170_HUMAN 89.384 0.998715 0.982955 CEP170 - Centrosomal protein of 170 kDa - Homo sapiens (Human) - CEP170 gene Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). Indicus|evm.model.CM009506.1.231 Q2HJH9 PDCD5_BOVIN 98.400 0.924812 1.064 PDCD5 - Programmed cell death protein 5 - Bos taurus (Bovine) - PDCD5 gene May function in the process of apoptosis. Indicus|evm.model.CM009506.1.232 Q8N7P1 PLD5_HUMAN 100.000 0.342541 0.337687 PLD5 - Inactive phospholipase D5 - Homo sapiens (Human) - PLD5 gene Indicus|evm.model.CM009506.1.233 Q8N7P1 PLD5_HUMAN 95.532 0.993644 0.880597 PLD5 - Inactive phospholipase D5 - Homo sapiens (Human) - PLD5 gene Indicus|evm.model.CM009506.1.234 A8MW95 BECN2_HUMAN 59.535 0.988426 1.00232 BECN2 - Beclin-2 - Homo sapiens (Human) - BECN2 gene Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1. Indicus|evm.model.CM009506.1.235 Q9BXW4 MLP3C_HUMAN 85.135 0.986577 1.01361 MAP1LC3C - Microtubule-associated proteins 1A/1B light chain 3C precursor - Homo sapiens (Human) - MAP1LC3C gene Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643). Indicus|evm.model.CM009506.1.236 Q9UQ84 EXO1_HUMAN 81.882 0.997608 0.98818 EXO1 - Exonuclease 1 - Homo sapiens (Human) - EXO1 gene 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. Indicus|evm.model.CM009506.1.237 B1ANS9 WDR64_HUMAN 84.949 0.998153 1.00185 WDR64 - WD repeat-containing protein 64 - Homo sapiens (Human) - WDR64 gene Indicus|evm.model.CM009506.1.238 P26374 RAE2_HUMAN 81.126 0.996933 0.993902 CHML - Rab proteins geranylgeranyltransferase component A 2 - Homo sapiens (Human) - CHML gene Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. Indicus|evm.model.CM009506.1.239 Q9MZS9 KMO_PIG 80.255 0.995536 0.951168 KMO - Kynurenine 3-monooxygenase - Sus scrofa (Pig) - KMO gene Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Indicus|evm.model.CM009506.1.240 P10173 FUMH_PIG 95.117 0.996086 0.998047 FH - Fumarate hydratase, mitochondrial precursor - Sus scrofa (Pig) - FH gene Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:21498518). Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). Indicus|evm.model.CM009506.1.241 O46470 RGS7_BOVIN 100.000 0.995745 1.00213 RGS7 - Regulator of G-protein signaling 7 - Bos taurus (Bovine) - RGS7 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. Indicus|evm.model.CM009506.1.242 P47961 RS4_CRIGR 75.229 0.930435 0.437262 RPS4 - 40S ribosomal protein S4 - Cricetulus griseus (Chinese hamster) - RPS4 gene Indicus|evm.model.CM009506.1.243 P47992 XCL1_HUMAN 69.298 0.982301 0.991228 XCL1 - Lymphotactin precursor - Homo sapiens (Human) - XCL1 gene Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. Indicus|evm.model.CM009506.1.244 P47992 XCL1_HUMAN 65.347 0.969388 0.859649 XCL1 - Lymphotactin precursor - Homo sapiens (Human) - XCL1 gene Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. Indicus|evm.model.CM009506.1.245 P19427 DERM_BOVIN 79.104 0.9875 0.79602 DPT - Dermatopontin precursor - Bos taurus (Bovine) - DPT gene Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation. Indicus|evm.model.CM009506.1.247 P05028 AT1B1_SHEEP 99.340 0.993421 1.0033 ATP1B1 - Sodium/potassium-transporting ATPase subunit beta-1 - Ovis aries (Sheep) - ATP1B1 gene This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Indicus|evm.model.CM009506.1.248 Q5E9Y9 NDK7_BOVIN 83.024 0.99375 0.848806 NME7 - Nucleoside diphosphate kinase 7 - Bos taurus (Bovine) - NME7 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Indicus|evm.model.CM009506.1.249 Q9H2G9 GO45_HUMAN 90.025 0.995025 1.005 BLZF1 - Golgin-45 - Homo sapiens (Human) - BLZF1 gene Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. Indicus|evm.model.CM009506.1.250 Q5TID7 CC181_HUMAN 83.529 0.973231 1.0275 CCDC181 - Coiled-coil domain-containing protein 181 - Homo sapiens (Human) - CCDC181 gene Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Indicus|evm.model.CM009506.1.251 O60779 S19A2_HUMAN 92.757 0.995976 1 SLC19A2 - Thiamine transporter 1 - Homo sapiens (Human) - SLC19A2 gene High-affinity transporter for the intake of thiamine. Indicus|evm.model.CM009506.1.252 Q28107 FA5_BOVIN 95.387 0.999059 0.961104 F5 - Coagulation factor V precursor - Bos taurus (Bovine) - F5 gene Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. Indicus|evm.model.CM009506.1.253 P42201 LYAM3_BOVIN 98.555 0.928358 1.03715 SELP - P-selectin precursor - Bos taurus (Bovine) - SELP gene Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes (PubMed:7683458). Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG (By similarity). Indicus|evm.model.CM009506.1.254 P98131 LYAM1_BOVIN 99.725 0.970588 1.01081 SELL - L-selectin precursor - Bos taurus (Bovine) - SELL gene Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Indicus|evm.model.CM009506.1.255 P98107 LYAM2_BOVIN 99.333 0.896208 1.03299 SELE - E-selectin precursor - Bos taurus (Bovine) - SELE gene Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. Indicus|evm.model.CM009506.1.256 Q2KIJ2 MET18_BOVIN 100.000 0.994652 1.00268 METTL18 - Histidine protein methyltransferase 1 homolog - Bos taurus (Bovine) - METTL18 gene Probable histidine methyltransferase. Indicus|evm.model.CM009506.1.257 Q9NSG2 CA112_HUMAN 84.099 0.971363 1.02345 C1orf112 - Uncharacterized protein C1orf112 - Homo sapiens (Human) - C1orf112 gene Indicus|evm.model.CM009506.1.258 Q8IZE3 PACE1_HUMAN 83.042 0.997279 0.990566 SCYL3 - Protein-associating with the carboxyl-terminal domain of ezrin - Homo sapiens (Human) - SCYL3 gene May play a role in regulating cell adhesion/migration complexes in migrating cells. Indicus|evm.model.CM009506.1.260 Q92845 KIFA3_HUMAN 95.581 0.996109 0.973485 KIFAP3 - Kinesin-associated protein 3 - Homo sapiens (Human) - KIFAP3 gene Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). Indicus|evm.model.CM009506.1.261 Q5VVY1 NTM1B_HUMAN 93.993 0.992958 1.00353 METTL11B - Alpha N-terminal protein methyltransferase 1B - Homo sapiens (Human) - METTL11B gene Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation. Indicus|evm.model.CM009506.1.263 A5PKK7 GORAB_BOVIN 100.000 0.931818 1.07027 GORAB - RAB6-interacting golgin - Bos taurus (Bovine) - GORAB gene Indicus|evm.model.CM009506.1.264 P63014 PRRX1_RAT 99.184 0.99187 1.00408 Prrx1 - Paired mesoderm homeobox protein 1 - Rattus norvegicus (Rat) - Prrx1 gene Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). Indicus|evm.model.CM009506.1.265 Q5TGP6 MROH9_HUMAN 71.264 0.114058 1.31588 MROH9 - Maestro heat-like repeat-containing protein family member 9 - Homo sapiens (Human) - MROH9 gene Indicus|evm.model.CM009506.1.266 Q8HYJ9 FMO3_BOVIN 99.812 0.996248 1.00188 FMO3 - Dimethylaniline monooxygenase [N-oxide-forming] 3 - Bos taurus (Bovine) - FMO3 gene Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation. Indicus|evm.model.CM009506.1.267 O60774 FMO6_HUMAN 85.462 0.996024 0.93321 FMO6P - Putative dimethylaniline monooxygenase [N-oxide-forming] 6 - Homo sapiens (Human) - FMO6P gene It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full-length transcripts. Indicus|evm.model.CM009506.1.268 Q8HZ70 FMO2_PANTR 85.553 0.996248 0.996262 FMO2 - Dimethylaniline monooxygenase [N-oxide-forming] 2 - Pan troglodytes (Chimpanzee) - FMO2 gene This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Indicus|evm.model.CM009506.1.271 P16549 FMO1_PIG 90.789 0.996248 1.00188 FMO1 - Dimethylaniline monooxygenase [N-oxide-forming] 1 - Sus scrofa (Pig) - FMO1 gene This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Indicus|evm.model.CM009506.1.272 P31512 FMO4_HUMAN 86.000 0.99637 0.987455 FMO4 - Dimethylaniline monooxygenase [N-oxide-forming] 4 - Homo sapiens (Human) - FMO4 gene This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Indicus|evm.model.CM009506.1.273 Q9Y520 PRC2C_HUMAN 88.923 0.999304 0.992403 PRRC2C - Protein PRRC2C - Homo sapiens (Human) - PRRC2C gene Required for efficient formation of stress granules. Indicus|evm.model.CM009506.1.274 Q9XTA3 MYOC_BOVIN 98.776 0.995927 1.00204 MYOC - Myocilin precursor - Bos taurus (Bovine) - MYOC gene Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork. Indicus|evm.model.CM009506.1.275 Q32L97 VAMP4_BOVIN 100.000 0.985915 1.00709 VAMP4 - Vesicle-associated membrane protein 4 - Bos taurus (Bovine) - VAMP4 gene Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity). Indicus|evm.model.CM009506.1.276 A5PK19 EFNMT_BOVIN 99.857 0.997143 1.00143 EEF1AKNMT - eEF1A lysine and N-terminal methyltransferase - Bos taurus (Bovine) - EEF1AKNMT gene Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'. Indicus|evm.model.CM009506.1.279 Q3ZBX1 PIGC_BOVIN 100.000 0.993289 1.00337 PIGC - Phosphatidylinositol N-acetylglucosaminyltransferase subunit C - Bos taurus (Bovine) - PIGC gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Indicus|evm.model.CM009506.1.280 O95561 CA105_HUMAN 68.508 0.782609 1.25683 C1orf105 - Uncharacterized protein C1orf105 - Homo sapiens (Human) - C1orf105 gene Indicus|evm.model.CM009506.1.281 Q9UBS9 SUCO_HUMAN 87.510 0.998396 0.994418 SUCO - SUN domain-containing ossification factor precursor - Homo sapiens (Human) - SUCO gene Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity). Indicus|evm.model.CM009506.1.282 Q861W5 TNFL6_FELCA 88.214 0.992806 0.992857 FASLG - Tumor necrosis factor ligand superfamily member 6 - Felis catus (Cat) - FASLG gene Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. Indicus|evm.model.CM009506.1.283 Q3T160 NPM_BOVIN 95.918 0.993127 0.989796 NPM1 - Nucleophosmin - Bos taurus (Bovine) - NPM1 gene Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Indicus|evm.model.CM009506.1.284 P50502 F10A1_HUMAN 82.143 0.954023 0.235772 ST13 - Hsc70-interacting protein - Homo sapiens (Human) - ST13 gene One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). Indicus|evm.model.CM009506.1.285 Q8IZP2 ST134_HUMAN 93.836 0.577689 1.04583 ST13P4 - Putative protein FAM10A4 - Homo sapiens (Human) - ST13P4 gene extracellular exosome, heat shock protein binding, chaperone cofactor-dependent protein refolding, protein-containing complex assembly Indicus|evm.model.CM009506.1.286 Q9UNG2 TNF18_HUMAN 76.316 0.982609 0.577889 TNFSF18 - Tumor necrosis factor ligand superfamily member 18 - Homo sapiens (Human) - TNFSF18 gene Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). Indicus|evm.model.CM009506.1.288 P23510 TNFL4_HUMAN 69.231 0.983607 1 TNFSF4 - Tumor necrosis factor ligand superfamily member 4 - Homo sapiens (Human) - TNFSF4 gene Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Indicus|evm.model.CM009506.1.289 Q8IX15 HOMEZ_HUMAN 88.095 0.497006 0.303636 HOMEZ - Homeobox and leucine zipper protein Homez - Homo sapiens (Human) - HOMEZ gene May function as a transcriptional regulator. Indicus|evm.model.CM009506.1.291 Q5VUY2 ADCL4_HUMAN 64.857 0.962857 0.859951 AADACL4 - Arylacetamide deacetylase-like 4 - Homo sapiens (Human) - AADACL4 gene hydrolase activity Indicus|evm.model.CM009506.1.292 O75911 DHRS3_HUMAN 99.569 0.895349 0.854305 DHRS3 - Short-chain dehydrogenase/reductase 3 - Homo sapiens (Human) - DHRS3 gene Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH. Indicus|evm.model.CM009506.1.293 Q5THJ4 VP13D_HUMAN 97.972 0.991672 0.328396 VPS13D - Vacuolar protein sorting-associated protein 13D - Homo sapiens (Human) - VPS13D gene Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. Indicus|evm.model.CM009506.1.294 Q5THJ4 VP13D_HUMAN 93.774 0.992248 0.0587967 VPS13D - Vacuolar protein sorting-associated protein 13D - Homo sapiens (Human) - VPS13D gene Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. Indicus|evm.model.CM009506.1.295 Q5THJ4 VP13D_HUMAN 92.932 0.997388 0.610757 VPS13D - Vacuolar protein sorting-associated protein 13D - Homo sapiens (Human) - VPS13D gene Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. Indicus|evm.model.CM009506.1.296 P20333 TNR1B_HUMAN 69.313 0.995652 0.997831 TNFRSF1B - Tumor necrosis factor receptor superfamily member 1B precursor - Homo sapiens (Human) - TNFRSF1B gene Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Indicus|evm.model.CM009506.1.297 P28908 TNR8_HUMAN 63.543 0.987973 0.978151 TNFRSF8 - Tumor necrosis factor receptor superfamily member 8 precursor - Homo sapiens (Human) - TNFRSF8 gene Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898). Indicus|evm.model.CM009506.1.298 Q5JXC2 MIIP_HUMAN 65.039 0.994152 0.881443 MIIP - Migration and invasion-inhibitory protein - Homo sapiens (Human) - MIIP gene Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. Indicus|evm.model.CM009506.1.299 O95140 MFN2_HUMAN 92.206 0.997249 0.96037 MFN2 - Mitofusin-2 - Homo sapiens (Human) - MFN2 gene Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:26214738, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). Indicus|evm.model.CM009506.1.300 Q63321 PLOD1_RAT 92.504 0.884181 0.972527 Plod1 - Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor - Rattus norvegicus (Rat) - Plod1 gene Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:7578263). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). Indicus|evm.model.CM009506.1.301 Q2KHV9 K2013_BOVIN 99.824 0.888715 1.00631 Uncharacterized protein KIAA2013 homolog precursor - Bos taurus (Bovine) Indicus|evm.model.CM009506.1.302 P13204 ANFB_BOVIN 100.000 0.984615 1.00775 NPPB - Natriuretic peptides B precursor - Bos taurus (Bovine) - NPPB gene Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3 (By similarity). Indicus|evm.model.CM009506.1.303 P07501 ANF_BOVIN 100.000 0.986928 1.00658 NPPA - Natriuretic peptides A precursor - Bos taurus (Bovine) - NPPA gene Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (By similarity). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (By similarity). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes upregulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity). Indicus|evm.model.CM009506.1.304 P51797 CLCN6_HUMAN 95.977 0.997704 1.0023 CLCN6 - Chloride transport protein 6 - Homo sapiens (Human) - CLCN6 gene Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. Indicus|evm.model.CM009506.1.305 Q5I598 MTHR_BOVIN 99.237 0.938307 1.06412 MTHFR - Methylenetetrahydrofolate reductase - Bos taurus (Bovine) - MTHFR gene Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Indicus|evm.model.CM009506.1.307 Q6RW13 ATRAP_HUMAN 74.214 0.693694 1.39623 AGTRAP - Type-1 angiotensin II receptor-associated protein - Homo sapiens (Human) - AGTRAP gene Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. Indicus|evm.model.CM009506.1.308 P0C8S2 DRAXI_BOVIN 100.000 0.994083 1.00297 DRAXIN - Draxin precursor - Bos taurus (Bovine) - DRAXIN gene Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. Indicus|evm.model.CM009506.1.309 Q9UI95 MD2L2_HUMAN 99.526 0.990566 1.00474 MAD2L2 - Mitotic spindle assembly checkpoint protein MAD2B - Homo sapiens (Human) - MAD2L2 gene Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:17719540, PubMed:17296730, PubMed:19443654, PubMed:29656893). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:20164194). Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194). Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 (PubMed:17296730). Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle (PubMed:11459825, PubMed:17719540). Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (PubMed:19443654). Indicus|evm.model.CM009506.1.310 Q3SX24 FBX6_BOVIN 100.000 0.992481 1.00377 FBXO6 - F-box only protein 6 - Bos taurus (Bovine) - FBXO6 gene Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Indicus|evm.model.CM009506.1.312 Q9H4M3 FBX44_HUMAN 97.647 0.992188 1.00392 FBXO44 - F-box only protein 44 - Homo sapiens (Human) - FBXO44 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009506.1.313 Q17QK6 FBX2_BOVIN 98.653 0.993289 1.00337 FBXO2 - F-box only protein 2 - Bos taurus (Bovine) - FBXO2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity). Indicus|evm.model.CM009506.1.314 Q9P2K9 DISP3_HUMAN 91.105 0.998565 1.00144 DISP3 - Protein dispatched homolog 3 - Homo sapiens (Human) - DISP3 gene Plays a role in neuronal proliferation and differentiation (PubMed:25281927). Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation (PubMed:25281927). May contribute to cholesterol homeostasis in neuronal cells (By similarity). Indicus|evm.model.CM009506.1.315 D2HKB0 UBIA1_AILME 94.529 0.984985 0.988131 UBIAD1 - UbiA prenyltransferase domain-containing protein 1 - Ailuropoda melanoleuca (Giant panda) - UBIAD1 gene Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress (By similarity). Indicus|evm.model.CM009506.1.316 P42345 MTOR_HUMAN 99.647 0.999216 1.00078 MTOR - Serine/threonine-protein kinase mTOR - Homo sapiens (Human) - MTOR gene Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18925875, PubMed:18497260, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (By similarity). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12150925, PubMed:12087098, PubMed:18925875). This also includes mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3: in the presence of nutrients, mediates phosphorylation of TFEB and TFE3, promoting their cytosolic retention and inactivation (PubMed:22576015, PubMed:22343943, PubMed:22692423). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22576015, PubMed:22343943, PubMed:22692423). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429704, PubMed:23429703). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (By similarity). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). mTORC1 also negatively regulates autophagy through phosphorylation of ULK1 (By similarity). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (By similarity). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton (PubMed:15268862, PubMed:15467718). Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1 (PubMed:15718470). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). Phosphorylates SQSTM1, promoting interaction between SQSTM1 and KEAP1 and subsequent inactivation of the BCR(KEAP1) complex (By similarity). Indicus|evm.model.CM009506.1.317 Q64674 SPEE_MOUSE 92.647 0.242181 3.7053 Srm - Spermidine synthase - Mus musculus (Mouse) - Srm gene Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine (By similarity). Indicus|evm.model.CM009506.1.318 O00187 MASP2_HUMAN 83.626 0.992722 1.00146 MASP2 - Mannan-binding lectin serine protease 2 precursor - Homo sapiens (Human) - MASP2 gene Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. Indicus|evm.model.CM009506.1.319 Q921F2 TADBP_MOUSE 98.068 0.995181 1.00242 Tardbp - TAR DNA-binding protein 43 - Mus musculus (Mouse) - Tardbp gene RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (By similarity). Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (By similarity). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). Indicus|evm.model.CM009506.1.321 Q86V15 CASZ1_HUMAN 92.948 0.977661 0.865264 CASZ1 - Zinc finger protein castor homolog 1 - Homo sapiens (Human) - CASZ1 gene Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). Indicus|evm.model.CM009506.1.322 O75381 PEX14_HUMAN 94.164 0.994667 0.994695 PEX14 - Peroxisomal membrane protein PEX14 - Homo sapiens (Human) - PEX14 gene Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin. Indicus|evm.model.CM009506.1.323 O00273 DFFA_HUMAN 78.788 0.990909 0.996979 DFFA - DNA fragmentation factor subunit alpha - Homo sapiens (Human) - DFFA gene Inhibitor of the caspase-activated DNase (DFF40). Indicus|evm.model.CM009506.1.324 O00230 CORT_HUMAN 67.416 0.727273 1.15238 CORT - Cortistatin precursor - Homo sapiens (Human) - CORT gene Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs. Indicus|evm.model.CM009506.1.325 Q2TBR7 CENPS_BOVIN 98.551 0.978571 1.01449 CENPS - Centromere protein S - Bos taurus (Bovine) - CENPS gene DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own. Indicus|evm.model.CM009506.1.326 P00349 6PGD_SHEEP 97.723 0.995868 1.00207 PGD - 6-phosphogluconate dehydrogenase, decarboxylating - Ovis aries (Sheep) - PGD gene Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Indicus|evm.model.CM009506.1.327 O60333 KIF1B_HUMAN 94.641 0.530266 0.909692 KIF1B - Kinesin-like protein KIF1B - Homo sapiens (Human) - KIF1B gene Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis. Indicus|evm.model.CM009506.1.328 P62264 RS14_MOUSE 93.939 0.833333 0.516556 Rps14 - 40S ribosomal protein S14 - Mus musculus (Mouse) - Rps14 gene cytosol, cytosolic small ribosomal subunit, mitochondrion, nucleolus, postsynaptic density, mRNA 5'-UTR binding, RNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, translation regulator activity Indicus|evm.model.CM009506.1.329 Q9ES00 UBE4B_MOUSE 97.901 0.663243 1.16198 Ube4b - Ubiquitin conjugation factor E4 B - Mus musculus (Mouse) - Ube4b gene Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (PubMed:11435423). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (By similarity). Indicus|evm.model.CM009506.1.330 Q96R05 RET7_HUMAN 87.313 0.985185 1.00746 RBP7 - Retinoid-binding protein 7 - Homo sapiens (Human) - RBP7 gene Intracellular transport of retinol. Indicus|evm.model.CM009506.1.331 Q0VD50 NMNA1_BOVIN 100.000 0.701754 1.41993 NMNAT1 - Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 - Bos taurus (Bovine) - NMNAT1 gene Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Protects against axonal degeneration following mechanical or toxic insults (By similarity). Indicus|evm.model.CM009506.1.332 Q5E9N2 CNBP1_BOVIN 100.000 0.356322 2.14815 CTNNBIP1 - Beta-catenin-interacting protein 1 - Bos taurus (Bovine) - CTNNBIP1 gene Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Indicus|evm.model.CM009506.1.333 O94985 CSTN1_HUMAN 88.947 0.970433 0.965341 CLSTN1 - Calsyntenin-1 precursor - Homo sapiens (Human) - CLSTN1 gene Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity). Indicus|evm.model.CM009506.1.334 O00329 PK3CD_HUMAN 95.307 0.998086 1.00096 PIK3CD - Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform - Homo sapiens (Human) - PIK3CD gene Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. Indicus|evm.model.CM009506.1.335 Q32PF0 TM201_BOVIN 100.000 0.578475 1.70229 TMEM201 - Transmembrane protein 201 - Bos taurus (Bovine) - TMEM201 gene May define a distinct membrane domain in the vicinity of the mitotic spindle. Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina. Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow. May recruit Ran GTPase to the nuclear periphery. Indicus|evm.model.CM009506.1.336 Q1LZB3 S2533_BOVIN 99.688 0.993789 1.00312 SLC25A33 - Solute carrier family 25 member 33 - Bos taurus (Bovine) - SLC25A33 gene Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production. Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation. Indicus|evm.model.CM009506.1.338 P58353 GTR5_BOVIN 99.678 0.537262 1.1517 SLC2A5 - Solute carrier family 2, facilitated glucose transporter member 5 - Bos taurus (Bovine) - SLC2A5 gene Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake. Indicus|evm.model.CM009506.1.339 P18915 CAH6_BOVIN 99.060 0.99375 1.00313 CA6 - Carbonic anhydrase 6 precursor - Bos taurus (Bovine) - CA6 gene Reversible hydration of carbon dioxide. Its role in saliva is unknown. Indicus|evm.model.CM009506.1.340 Q9XSJ4 ENOA_BOVIN 99.770 0.995402 1.0023 ENO1 - Alpha-enolase - Bos taurus (Bovine) - ENO1 gene Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:7499243). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). Indicus|evm.model.CM009506.1.341 Q9P2R6 RERE_HUMAN 95.772 0.377083 0.91954 RERE - Arginine-glutamic acid dipeptide repeats protein - Homo sapiens (Human) - RERE gene Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. Indicus|evm.model.CM009506.1.342 Q8BIV7 S45A1_MOUSE 86.728 0.940594 1.0759 Slc45a1 - Proton-associated sugar transporter A - Mus musculus (Mouse) - Slc45a1 gene Proton-associated glucose transporter in the brain. Indicus|evm.model.CM009506.1.343 Q5JX71 F209A_HUMAN 45.349 0.78972 1.25146 FAM209A - Protein FAM209A precursor - Homo sapiens (Human) - FAM209A gene extracellular exosome, nucleus Indicus|evm.model.CM009506.1.345 Q9UJM3 ERRFI_HUMAN 77.922 0.995662 0.997835 ERRFI1 - ERBB receptor feedback inhibitor 1 - Homo sapiens (Human) - ERRFI1 gene Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). Indicus|evm.model.CM009506.1.347 Q5E946 PARK7_BOVIN 100.000 0.989474 1.00529 PARK7 - Parkinson disease protein 7 homolog precursor - Bos taurus (Bovine) - PARK7 gene Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. But this function is rebuted by other works. As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin. Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels. Displays a very low glyoxalase activity that may reflect its deglycase activity. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity. In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis. Indicus|evm.model.CM009506.1.348 Q07011 TNR9_HUMAN 74.118 0.992157 1 TNFRSF9 - Tumor necrosis factor receptor superfamily member 9 precursor - Homo sapiens (Human) - TNFRSF9 gene Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. Indicus|evm.model.CM009506.1.349 P56645 PER3_HUMAN 64.546 0.812777 0.938385 PER3 - Period circadian protein homolog 3 - Homo sapiens (Human) - PER3 gene Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. Indicus|evm.model.CM009506.1.350 Q2KJD2 VAMP3_BOVIN 100.000 0.684564 1.43269 VAMP3 - Vesicle-associated membrane protein 3 - Bos taurus (Bovine) - VAMP3 gene SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Indicus|evm.model.CM009506.1.351 Q9Y6Y1 CMTA1_HUMAN 94.134 0.929825 0.919904 CAMTA1 - Calmodulin-binding transcription activator 1 - Homo sapiens (Human) - CAMTA1 gene Transcriptional activator. May act as a tumor suppressor. Indicus|evm.model.CM009506.1.354 Q2NL21 DJC11_BOVIN 100.000 0.996429 1.00179 DNAJC11 - DnaJ homolog subfamily C member 11 - Bos taurus (Bovine) - DNAJC11 gene Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. Indicus|evm.model.CM009506.1.355 Q0P5B4 THAP3_BOVIN 99.582 0.991667 1.00418 THAP3 - THAP domain-containing protein 3 - Bos taurus (Bovine) - THAP3 gene Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Indicus|evm.model.CM009506.1.356 Q86YI8 PHF13_HUMAN 95.000 0.993355 1.00333 PHF13 - PHD finger protein 13 - Homo sapiens (Human) - PHF13 gene Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. Indicus|evm.model.CM009506.1.357 Q08DS0 KLH21_BOVIN 99.832 0.996656 1.00168 KLHL21 - Kelch-like protein 21 - Bos taurus (Bovine) - KLHL21 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity). Indicus|evm.model.CM009506.1.358 P10074 TZAP_HUMAN 92.587 0.958159 1.04215 ZBTB48 - Telomere zinc finger-associated protein - Homo sapiens (Human) - ZBTB48 gene Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). Indicus|evm.model.CM009506.1.359 Q7RTX1 TS1R1_HUMAN 75.743 0.997625 1.00119 TAS1R1 - Taste receptor type 1 member 1 precursor - Homo sapiens (Human) - TAS1R1 gene Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. Indicus|evm.model.CM009506.1.360 E1BPN0 NOL9_BOVIN 99.568 0.997122 1.00144 NOL9 - Polynucleotide 5'-hydroxyl-kinase NOL9 - Bos taurus (Bovine) - NOL9 gene Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA (By similarity). Indicus|evm.model.CM009506.1.361 O94827 PKHG5_HUMAN 87.673 0.90868 1.0994 PLEKHG5 - Pleckstrin homology domain-containing family G member 5 - Homo sapiens (Human) - PLEKHG5 gene Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation (PubMed:11704860). Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (PubMed:23777631). Indicus|evm.model.CM009506.1.362 Q93038 TNR25_HUMAN 74.559 0.937799 1.0024 TNFRSF25 - Tumor necrosis factor receptor superfamily member 25 precursor - Homo sapiens (Human) - TNFRSF25 gene Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. Indicus|evm.model.CM009506.1.363 B1AK53 ESPN_HUMAN 90.541 0.776596 0.11007 ESPN - Espin - Homo sapiens (Human) - ESPN gene Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:29572253). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (By similarity). Involved in the elongation of actin in stereocilia (PubMed:29572253). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation. Indicus|evm.model.CM009506.1.364 B1AK53 ESPN_HUMAN 72.562 0.537336 1.52108 ESPN - Espin - Homo sapiens (Human) - ESPN gene Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:29572253). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (By similarity). Involved in the elongation of actin in stereocilia (PubMed:29572253). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation. Indicus|evm.model.CM009506.1.365 Q9Y543 HES2_HUMAN 88.889 0.807229 0.959538 HES2 - Transcription factor HES-2 - Homo sapiens (Human) - HES2 gene Transcriptional repressor of genes that require a bHLH protein for their transcription. Indicus|evm.model.CM009506.1.366 Q5RBT3 NAA35_PONAB 97.156 0.990566 0.292414 NAA35 - N-alpha-acetyltransferase 35, NatC auxiliary subunit - Pongo abelii (Sumatran orangutan) - NAA35 gene Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells (By similarity). Indicus|evm.model.CM009506.1.367 Q5RBT3 NAA35_PONAB 95.763 0.88015 0.368276 NAA35 - N-alpha-acetyltransferase 35, NatC auxiliary subunit - Pongo abelii (Sumatran orangutan) - NAA35 gene Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells (By similarity). Indicus|evm.model.CM009506.1.368 Q91V12 BACH_MOUSE 94.479 0.958702 0.889764 Acot7 - Cytosolic acyl coenzyme A thioester hydrolase - Mus musculus (Mouse) - Acot7 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:15288813). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (Probable). May play an important physiological function in brain (PubMed:15288813). Indicus|evm.model.CM009506.1.369 Q6NV75 GP153_HUMAN 92.625 0.747954 1.00328 GPR153 - Probable G-protein coupled receptor 153 - Homo sapiens (Human) - GPR153 gene Orphan receptor. Indicus|evm.model.CM009506.1.370 Q5TGS1 HES3_HUMAN 76.404 0.867647 1.09677 HES3 - Transcription factor HES-3 - Homo sapiens (Human) - HES3 gene Transcriptional repressor of genes that require a bHLH protein for their transcription. Indicus|evm.model.CM009506.1.371 O60725 ICMT_HUMAN 96.809 0.989418 0.665493 ICMT - Protein-S-isoprenylcysteine O-methyltransferase - Homo sapiens (Human) - ICMT gene Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. Indicus|evm.model.CM009506.1.372 A0JNG4 RN207_BOVIN 92.530 0.927445 1.14029 RNF207 - RING finger protein 207 - Bos taurus (Bovine) - RNF207 gene Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. Indicus|evm.model.CM009506.1.373 P67985 RL22_PIG 100.000 0.984496 1.00781 RPL22 - 60S ribosomal protein L22 - Sus scrofa (Pig) - RPL22 gene cytoplasmic side of rough endoplasmic reticulum membrane, large ribosomal subunit, RNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009506.1.374 Q8TDI0 CHD5_HUMAN 95.614 0.986598 0.992835 CHD5 - Chromodomain-helicase-DNA-binding protein 5 - Homo sapiens (Human) - CHD5 gene Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. Indicus|evm.model.CM009506.1.375 Q27955 KCAB2_BOVIN 100.000 0.994565 1.00272 KCNAB2 - Voltage-gated potassium channel subunit beta-2 - Bos taurus (Bovine) - KCNAB2 gene Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (By similarity). Promotes KCNA4 channel closure (By similarity). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity). Indicus|evm.model.CM009506.1.378 O75161 NPHP4_HUMAN 78.212 0.998603 1.00421 NPHP4 - Nephrocystin-4 - Homo sapiens (Human) - NPHP4 gene Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). Indicus|evm.model.CM009506.1.379 Q0EEE2 PTHD3_MOUSE 68.260 0.993506 0.84989 Ptchd3 - Patched domain-containing protein 3 - Mus musculus (Mouse) - Ptchd3 gene May play a role in sperm development or sperm function. Indicus|evm.model.CM009506.1.380 P13789 TNNT2_BOVIN 98.413 0.881517 0.740351 TNNT2 - Troponin T, cardiac muscle - Bos taurus (Bovine) - TNNT2 gene Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Indicus|evm.model.CM009506.1.381 O00515 LAD1_HUMAN 47.399 0.808795 1.01161 LAD1 - Ladinin-1 - Homo sapiens (Human) - LAD1 gene Anchoring filament protein which is a component of the basement membrane zone. Indicus|evm.model.CM009506.1.382 P19237 TNNI1_HUMAN 96.809 0.989418 1.0107 TNNI1 - Troponin I, slow skeletal muscle - Homo sapiens (Human) - TNNI1 gene Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Indicus|evm.model.CM009506.1.383 Q3MHY1 CSRP1_BOVIN 100.000 0.989691 1.00518 CSRP1 - Cysteine and glycine-rich protein 1 - Bos taurus (Bovine) - CSRP1 gene Could play a role in neuronal development. Indicus|evm.model.CM009506.1.384 Q8NEY1 NAV1_HUMAN 91.986 0.354193 0.425679 NAV1 - Neuron navigator 1 - Homo sapiens (Human) - NAV1 gene May be involved in neuronal migration. Indicus|evm.model.CM009506.1.385 Q8NEY1 NAV1_HUMAN 92.234 0.987179 0.789558 NAV1 - Neuron navigator 1 - Homo sapiens (Human) - NAV1 gene May be involved in neuronal migration. Indicus|evm.model.CM009506.1.386 Q96P70 IPO9_HUMAN 93.571 0.98249 0.987512 IPO9 - Importin-9 - Homo sapiens (Human) - IPO9 gene Functions in nuclear protein import as nuclear transport receptor (PubMed:11823430). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone (PubMed:11823430). Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains (PubMed:11823430). Mediates the nuclear import of actin (By similarity). Indicus|evm.model.CM009506.1.387 Q96DD7 SHSA4_HUMAN 92.857 0.816993 0.77665 SHISA4 - Protein shisa-4 precursor - Homo sapiens (Human) - SHISA4 gene Indicus|evm.model.CM009506.1.388 P29536 LMOD1_HUMAN 75.828 0.996546 0.965 LMOD1 - Leiomodin-1 - Homo sapiens (Human) - LMOD1 gene Mediates nucleation of actin filaments. Indicus|evm.model.CM009506.1.389 Q99595 TI17A_HUMAN 95.906 0.988372 1.00585 TIMM17A - Mitochondrial import inner membrane translocase subunit Tim17-A - Homo sapiens (Human) - TIMM17A gene Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Indicus|evm.model.CM009506.1.390 Q9UKB5 AJAP1_HUMAN 84.173 0.995204 1.0146 AJAP1 - Adherens junction-associated protein 1 - Homo sapiens (Human) - AJAP1 gene Plays a role in cell adhesion and cell migration. Indicus|evm.model.CM009506.1.396 Q32PF7 CA174_BOVIN 100.000 0.991597 1.00422 UPF0688 protein C1orf174 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009506.1.397 Q58CZ0 DFFB_BOVIN 99.413 0.994152 1.00293 DFFB - DNA fragmentation factor subunit beta - Bos taurus (Bovine) - DFFB gene Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology (By similarity). Indicus|evm.model.CM009506.1.398 O60308 CE104_HUMAN 83.135 0.972632 1.02703 CEP104 - Centrosomal protein of 104 kDa - Homo sapiens (Human) - CEP104 gene Required for ciliogenesis and for structural integrity at the ciliary tip. Indicus|evm.model.CM009506.1.399 Q8N1G4 LRC47_HUMAN 83.505 0.949097 1.0446 LRRC47 - Leucine-rich repeat-containing protein 47 - Homo sapiens (Human) - LRRC47 gene RNA binding Indicus|evm.model.CM009506.1.400 P0C8K7 SMIM1_MOUSE 70.513 0.566176 1.74359 Smim1 - Small integral membrane protein 1 - Mus musculus (Mouse) - Smim1 gene Regulator of red blood cell formation. Indicus|evm.model.CM009506.1.401 Q2M243 CCD27_HUMAN 57.405 0.987768 0.996951 CCDC27 - Coiled-coil domain-containing protein 27 - Homo sapiens (Human) - CCDC27 gene Indicus|evm.model.CM009506.1.402 Q9JJP2 P73_MOUSE 89.314 0.975039 1.01585 Tp73 - Tumor protein p73 - Mus musculus (Mouse) - Tp73 gene Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Indicus|evm.model.CM009506.1.403 Q9P2S5 WRP73_HUMAN 87.391 0.995643 0.997826 WRAP73 - WD repeat-containing protein WRAP73 - Homo sapiens (Human) - WRAP73 gene The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238). Indicus|evm.model.CM009506.1.404 Q32LJ4 TPRGL_BOVIN 100.000 0.749153 1.07273 TPRG1L - Tumor protein p63-regulated gene 1-like protein - Bos taurus (Bovine) - TPRG1L gene Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release. Indicus|evm.model.CM009506.1.405 Q80V70 MEGF6_MOUSE 77.081 0.9769 1.04644 Megf6 - Multiple epidermal growth factor-like domains protein 6 precursor - Mus musculus (Mouse) - Megf6 gene collagen-containing extracellular matrix Indicus|evm.model.CM009506.1.406 Q5VV41 ARHGG_HUMAN 83.075 0.656453 1.51904 ARHGEF16 - Rho guanine nucleotide exchange factor 16 - Homo sapiens (Human) - ARHGEF16 gene Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. Indicus|evm.model.CM009506.1.407 A2A935 PRD16_MOUSE 88.604 0.99735 0.887843 Prdm16 - Histone-lysine N-methyltransferase PRDM16 - Mus musculus (Mouse) - Prdm16 gene Binds DNA and functions as a transcriptional regulator (PubMed:18483224). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (PubMed:22939622). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (PubMed:22939622). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (PubMed:17618855, PubMed:18483224). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (PubMed:18719582, PubMed:19641492). Functions as a repressor of TGF-beta signaling. Indicus|evm.model.CM009506.1.409 A2A935 PRD16_MOUSE 83.621 0.700637 0.123137 Prdm16 - Histone-lysine N-methyltransferase PRDM16 - Mus musculus (Mouse) - Prdm16 gene Binds DNA and functions as a transcriptional regulator (PubMed:18483224). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (PubMed:22939622). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (PubMed:22939622). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (PubMed:17618855, PubMed:18483224). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (PubMed:18719582, PubMed:19641492). Functions as a repressor of TGF-beta signaling. Indicus|evm.model.CM009506.1.411 Q2TA43 ACTT2_BOVIN 100.000 0.994709 1.00265 ACTRT2 - Actin-related protein T2 - Bos taurus (Bovine) - ACTRT2 gene Indicus|evm.model.CM009506.1.412 Q3SZN0 SEPT6_BOVIN 69.670 0.938356 0.683841 SEPTIN6 - Septin-6 - Bos taurus (Bovine) - SEPTIN6 gene Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Indicus|evm.model.CM009506.1.413 A8MYJ7 TTC34_HUMAN 75.265 0.597884 1.66961 TTC34 - Tetratricopeptide repeat protein 34 - Homo sapiens (Human) - TTC34 gene Indicus|evm.model.CM009506.1.414 Q495T6 MMEL1_HUMAN 77.407 0.953715 1.05392 MMEL1 - Membrane metallo-endopeptidase-like 1 - Homo sapiens (Human) - MMEL1 gene Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). Indicus|evm.model.CM009506.1.415 Q58CY6 PXL2B_BOVIN 99.502 0.990099 1.00498 PRXL2B - Prostamide/prostaglandin F synthase - Bos taurus (Bovine) - PRXL2B gene Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity). Indicus|evm.model.CM009506.1.416 Q03062 HES5_RAT 86.471 0.987952 1 Hes5 - Transcription factor HES-5 - Rattus norvegicus (Rat) - Hes5 gene Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity). Indicus|evm.model.CM009506.1.417 Q4R4U1 PANK4_MACFA 94.696 0.997416 1.00129 PANK4 - 4'-phosphopantetheine phosphatase - Macaca fascicularis (Crab-eating macaque) - PANK4 gene May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'-phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. Indicus|evm.model.CM009506.1.418 A2AP18 PLCH2_MOUSE 81.143 0.988522 0.928714 Plch2 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 - Mus musculus (Mouse) - Plch2 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain. Indicus|evm.model.CM009506.1.419 O60683 PEX10_HUMAN 77.301 0.993846 0.996933 PEX10 - Peroxisome biogenesis factor 10 - Homo sapiens (Human) - PEX10 gene Somewhat implicated in the biogenesis of peroxisomes. Indicus|evm.model.CM009506.1.420 A5PJ65 RER1_BOVIN 99.490 0.667808 1.4898 RER1 - Protein RER1 - Bos taurus (Bovine) - RER1 gene Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. Indicus|evm.model.CM009506.1.421 Q5T089 MORN1_HUMAN 63.410 0.995434 0.881288 MORN1 - MORN repeat-containing protein 1 - Homo sapiens (Human) - MORN1 gene Indicus|evm.model.CM009506.1.422 Q9TUG2 SKI_HORSE 92.099 0.683587 0.809589 SKI - Ski oncogene - Equus caballus (Horse) - SKI gene May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling (By similarity). Indicus|evm.model.CM009506.1.423 P12755 SKI_HUMAN 99.327 0.89426 0.45467 SKI - Ski oncogene - Homo sapiens (Human) - SKI gene May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. Indicus|evm.model.CM009506.1.424 A5PKK9 FAP20_BOVIN 98.958 0.989637 1.00521 FAAP20 - Fanconi anemia core complex-associated protein 20 - Bos taurus (Bovine) - FAAP20 gene Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity). Indicus|evm.model.CM009506.1.425 P09217 KPCZ_RAT 93.434 0.996639 1.00507 Prkcz - Protein kinase C zeta type - Rattus norvegicus (Rat) - Prkcz gene Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (By similarity). Indicus|evm.model.CM009506.1.426 O14764 GBRD_HUMAN 92.255 0.960089 0.997788 GABRD - Gamma-aminobutyric acid receptor subunit delta precursor - Homo sapiens (Human) - GABRD gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Indicus|evm.model.CM009506.1.428 Q9C0B2 CFA74_HUMAN 71.877 0.845708 1.08838 CFAP74 - Cilia- and flagella-associated protein 74 - Homo sapiens (Human) - CFAP74 gene As part of the central apparatus of the cilium axoneme may play a role in cilium movement. Indicus|evm.model.CM009506.1.429 Q8NDY8 TMM52_HUMAN 78.912 0.858824 0.813397 TMEM52 - Transmembrane protein 52 precursor - Homo sapiens (Human) - TMEM52 gene Indicus|evm.model.CM009506.1.430 Q8TD86 CALL6_HUMAN 54.404 0.979167 1.06077 CALML6 - Calmodulin-like protein 6 - Homo sapiens (Human) - CALML6 gene calcium ion binding, enzyme regulator activity Indicus|evm.model.CM009506.1.432 P54311 GBB1_RAT 100.000 0.994135 1.00294 Gnb1 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 - Rattus norvegicus (Rat) - Gnb1 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009506.1.433 O95544 NADK_HUMAN 90.115 0.955947 1.01794 NADK - NAD kinase - Homo sapiens (Human) - NADK gene cytosol, NAD+ kinase activity, ATP metabolic process, NAD metabolic process, NADP biosynthetic process, phosphorylation Indicus|evm.model.CM009506.1.434 P0CK96 S352B_HUMAN 83.416 0.992611 1.00247 SLC35E2B - Solute carrier family 35 member E2B - Homo sapiens (Human) - SLC35E2B gene Putative transporter. Indicus|evm.model.CM009506.1.435 P21127 CD11B_HUMAN 94.975 0.955882 1.02642 CDK11B - Cyclin-dependent kinase 11B - Homo sapiens (Human) - CDK11B gene Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. Indicus|evm.model.CM009506.1.436 Q2TBM7 MMP23_BOVIN 99.746 0.994924 1.00254 MMP23 - Matrix metalloproteinase-23 precursor - Bos taurus (Bovine) - MMP23 gene Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity). Indicus|evm.model.CM009506.1.437 Q96AX9 MIB2_HUMAN 84.289 0.997982 0.978282 MIB2 - E3 ubiquitin-protein ligase MIB2 - Homo sapiens (Human) - MIB2 gene E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Indicus|evm.model.CM009506.1.438 F2Z333 FND10_HUMAN 88.235 0.982456 0.756637 FNDC10 - Fibronectin type III domain-containing protein 10 precursor - Homo sapiens (Human) - FNDC10 gene Indicus|evm.model.CM009506.1.439 Q17QI2 SSU72_BOVIN 100.000 0.97076 0.881443 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Indicus|evm.model.CM009506.1.440 Q5SV17 TM240_HUMAN 98.639 0.986486 0.855491 TMEM240 - Transmembrane protein 240 - Homo sapiens (Human) - TMEM240 gene synaptic membrane Indicus|evm.model.CM009506.1.441 A7YWC4 ATAD3_BOVIN 99.829 0.854015 1.16894 ATAD3 - ATPase family AAA domain-containing protein 3 - Bos taurus (Bovine) - ATAD3 gene Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity. Indicus|evm.model.CM009506.1.442 A6QLN9 VWA1_BOVIN 100.000 0.995169 1.00242 VWA1 - von Willebrand factor A domain-containing protein 1 precursor - Bos taurus (Bovine) - VWA1 gene Promotes matrix assembly. Indicus|evm.model.CM009506.1.443 Q0VD38 TM88B_BOVIN 100.000 0.988024 1.00602 TMEM88B - Transmembrane protein 88B - Bos taurus (Bovine) - TMEM88B gene plasma membrane, PDZ domain binding Indicus|evm.model.CM009506.1.444 A6QPE7 ANR65_BOVIN 99.747 0.994949 1.00253 ANKRD65 - Ankyrin repeat domain-containing protein 65 - Bos taurus (Bovine) - ANKRD65 gene Indicus|evm.model.CM009506.1.445 Q2TBR2 RM20_BOVIN 100.000 0.986667 1.00671 MRPL20 - 39S ribosomal protein L20, mitochondrial precursor - Bos taurus (Bovine) - MRPL20 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, structural constituent of ribosome, ribosomal large subunit assembly Indicus|evm.model.CM009506.1.446 Q96S94 CCNL2_HUMAN 92.638 0.93666 1.00192 CCNL2 - Cyclin-L2 - Homo sapiens (Human) - CCNL2 gene Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Indicus|evm.model.CM009506.1.447 Q9NWT8 AKIP_HUMAN 74.874 0.99 1.00503 AURKAIP1 - Aurora kinase A-interacting protein - Homo sapiens (Human) - AURKAIP1 gene May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation. Indicus|evm.model.CM009506.1.448 Q148M6 MXRA8_BOVIN 100.000 0.99569 1.00216 MXRA8 - Matrix remodeling-associated protein 8 precursor - Bos taurus (Bovine) - MXRA8 gene Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro. Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38. Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes. Stimulates formation of primary cilia in chondrocytes. Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway. Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis. Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells. Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK. May play a role in the maturation and maintenance of the blood-brain barrier. Indicus|evm.model.CM009506.1.449 Q9WVB9 DVL1_RAT 96.270 0.992933 0.814388 Dvl1 - Segment polarity protein dishevelled homolog DVL-1 - Rattus norvegicus (Rat) - Dvl1 gene Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Indicus|evm.model.CM009506.1.450 Q2TA03 UB2J2_BOVIN 99.614 0.992308 1.00386 UBE2J2 - Ubiquitin-conjugating enzyme E2 J2 - Bos taurus (Bovine) - UBE2J2 gene Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Indicus|evm.model.CM009506.1.451 Q5T7M4 ADIPL_HUMAN 68.562 0.986667 0.993377 C1QTNF12 - Adipolin precursor - Homo sapiens (Human) - C1QTNF12 gene Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. Indicus|evm.model.CM009506.1.452 Q96L58 B3GT6_HUMAN 93.227 0.757576 1.00304 B3GALT6 - Beta-1,3-galactosyltransferase 6 - Homo sapiens (Human) - B3GALT6 gene Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues. Indicus|evm.model.CM009506.1.453 Q3ZBZ1 CAB45_BOVIN 100.000 0.923077 0.769014 SDF4 - 45 kDa calcium-binding protein precursor - Bos taurus (Bovine) - SDF4 gene May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Indicus|evm.model.CM009506.1.454 P43489 TNR4_HUMAN 62.724 0.992832 1.00722 TNFRSF4 - Tumor necrosis factor receptor superfamily member 4 precursor - Homo sapiens (Human) - TNFRSF4 gene Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. Indicus|evm.model.CM009506.1.455 Q9Y5U5 TNR18_HUMAN 64.979 0.987013 0.958506 TNFRSF18 - Tumor necrosis factor receptor superfamily member 18 precursor - Homo sapiens (Human) - TNFRSF18 gene Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. Indicus|evm.model.CM009506.1.456 A4Q9F3 TTL10_MOUSE 74.211 0.834074 0.958807 Ttll10 - Protein polyglycylase TTLL10 - Mus musculus (Mouse) - Ttll10 gene Polyglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Polyglycylates alpha-tubulin and beta-tubulin, but is not able to initiate glycylation and only has activity toward monoglycylated tubulin. Has the ability to polyglycylate non-tubulin proteins such as NAP1; in this case it can initiate glycylation and does not require preliminary monoglycylation by another glycylase. Indicus|evm.model.CM009506.1.457 Q49KI5 TS1R3_FELCA 76.512 0.912206 0.539884 TAS1R3 - Taste receptor type 1 member 3 precursor - Felis catus (Cat) - TAS1R3 gene Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) (By similarity). Indicus|evm.model.CM009506.1.458 Q49HH9 TS1R3_CANLF 81.525 0.692464 0.581065 TAS1R3 - Taste receptor type 1 member 3 precursor - Canis lupus familiaris (Dog) - TAS1R3 gene Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity). Indicus|evm.model.CM009506.1.459 Q0VCQ0 CPTP_BOVIN 100.000 0.990698 1.00467 CPTP - Ceramide-1-phosphate transfer protein - Bos taurus (Bovine) - CPTP gene Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis. Indicus|evm.model.CM009506.1.460 Q2YDM2 INT11_BOVIN 99.833 0.996667 1.00167 INTS11 - Integrator complex subunit 11 - Bos taurus (Bovine) - INTS11 gene Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Indicus|evm.model.CM009506.1.461 Q8N0Z8 PUSL1_HUMAN 84.912 0.934211 1.0033 PUSL1 - tRNA pseudouridine synthase-like 1 - Homo sapiens (Human) - PUSL1 gene intracellular membrane-bounded organelle, mitochondrion, pseudouridine synthase activity, tRNA pseudouridine synthesis Indicus|evm.model.CM009506.1.462 P51172 SCNND_HUMAN 62.295 0.9375 0.798005 SCNN1D - Amiloride-sensitive sodium channel subunit delta - Homo sapiens (Human) - SCNN1D gene Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Indicus|evm.model.CM009506.1.463 Q96P50 ACAP3_HUMAN 91.839 0.932648 1.05036 ACAP3 - Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 - Homo sapiens (Human) - ACAP3 gene GTPase-activating protein for the ADP ribosylation factor family. Indicus|evm.model.CM009506.1.464 Q96HA4 CA159_HUMAN 69.718 0.700508 0.518421 C1orf159 - Uncharacterized protein C1orf159 precursor - Homo sapiens (Human) - C1orf159 gene Indicus|evm.model.CM009506.1.465 E7ERA6 RN223_HUMAN 80.088 0.9 1.00402 RNF223 - RING finger protein 223 - Homo sapiens (Human) - RNF223 gene Indicus|evm.model.CM009506.1.466 O00468 AGRIN_HUMAN 84.837 0.775221 1.26064 AGRN - Agrin precursor - Homo sapiens (Human) - AGRN gene heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain. Indicus|evm.model.CM009506.1.467 O02741 ISG15_BOVIN 100.000 0.987097 1.00649 ISG15 - Ubiquitin-like protein ISG15 - Bos taurus (Bovine) - ISG15 gene Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated-killer (LAK) activity, induce dendritic cell maturation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity (By similarity). The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (By similarity). In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (PubMed:9546718). Indicus|evm.model.CM009506.1.468 Q9HCC6 HES4_HUMAN 74.667 0.991031 1.00905 HES4 - Transcription factor HES-4 - Homo sapiens (Human) - HES4 gene Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity). Indicus|evm.model.CM009506.1.469 A5D7L8 PERM1_BOVIN 99.223 0.997783 1.00111 PERM1 - PGC-1 and ERR-induced regulator in muscle protein 1 - Bos taurus (Bovine) - PERM1 gene Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4 (By similarity). Indicus|evm.model.CM009506.1.470 Q494U1 PKHN1_HUMAN 70.407 0.996689 0.988543 PLEKHN1 - Pleckstrin homology domain-containing family N member 1 - Homo sapiens (Human) - PLEKHN1 gene Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 (PubMed:29180010). Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) (PubMed:18191643). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells (PubMed:29531808) (By similarity). Indicus|evm.model.CM009506.1.471 Q8K430 KLH17_RAT 97.823 0.996894 1.00625 Klhl17 - Kelch-like protein 17 - Rattus norvegicus (Rat) - Klhl17 gene Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function. Indicus|evm.model.CM009506.1.472 Q3SYU1 NOC2L_BOVIN 99.866 0.997323 1.00134 NOC2L - Nucleolar complex protein 2 homolog - Bos taurus (Bovine) - NOC2L gene Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity). Indicus|evm.model.CM009506.1.473 Q96NU1 SAM11_HUMAN 82.507 0.786808 1.2467 SAMD11 - Sterile alpha motif domain-containing protein 11 - Homo sapiens (Human) - SAMD11 gene May play a role in photoreceptor development. Indicus|evm.model.CM009506.1.474 Q13105 ZBT17_HUMAN 93.151 0.926316 1.06476 ZBTB17 - Zinc finger and BTB domain-containing protein 17 - Homo sapiens (Human) - ZBTB17 gene Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). Indicus|evm.model.CM009506.1.475 Q96T58 MINT_HUMAN 87.480 0.999453 0.996998 SPEN - Msx2-interacting protein - Homo sapiens (Human) - SPEN gene May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. Indicus|evm.model.CM009506.1.476 Q5R8Z6 MCFD2_PONAB 91.781 0.986301 1 MCFD2 - Multiple coagulation factor deficiency protein 2 homolog precursor - Pongo abelii (Sumatran orangutan) - MCFD2 gene The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Indicus|evm.model.CM009506.1.478 Q1JQB5 FBLI1_BOVIN 99.471 0.994723 1.00265 FBLIM1 - Filamin-binding LIM protein 1 - Bos taurus (Bovine) - FBLIM1 gene Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). Indicus|evm.model.CM009506.1.479 A0PJX8 TMM82_HUMAN 81.791 0.965217 1.00583 TMEM82 - Transmembrane protein 82 - Homo sapiens (Human) - TMEM82 gene Indicus|evm.model.CM009506.1.480 Q3SZK0 S2534_BOVIN 99.671 0.993443 1.00329 SLC25A34 - Solute carrier family 25 member 34 - Bos taurus (Bovine) - SLC25A34 gene Indicus|evm.model.CM009506.1.483 Q8IWE5 PKHM2_HUMAN 89.960 0.979512 1.00589 PLEKHM2 - Pleckstrin homology domain-containing family M member 2 - Homo sapiens (Human) - PLEKHM2 gene Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:28325809, PubMed:22172677, PubMed:25898167, PubMed:24088571). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). Indicus|evm.model.CM009506.1.484 Q5TDH0 DDI2_HUMAN 96.212 0.386497 2.5614 DDI2 - Protein DDI1 homolog 2 - Homo sapiens (Human) - DDI2 gene Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). Indicus|evm.model.CM009506.1.485 Q9BSE5 SPEB_HUMAN 85.278 0.991713 1.02841 AGMAT - Agmatinase, mitochondrial precursor - Homo sapiens (Human) - AGMAT gene mitochondrion, agmatinase activity, agmatine biosynthetic process, putrescine biosynthetic process from arginine, using agmatinase Indicus|evm.model.CM009506.1.486 Q9Y2G8 DJC16_HUMAN 93.350 0.997446 1.00128 DNAJC16 - DnaJ homolog subfamily C member 16 precursor - Homo sapiens (Human) - DNAJC16 gene Indicus|evm.model.CM009506.1.487 Q8C3Q9 CASP9_MOUSE 76.821 0.995585 0.997797 Casp9 - Caspase-9 precursor - Mus musculus (Mouse) - Casp9 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) (By similarity). Indicus|evm.model.CM009506.1.488 Q7M3E1 CTRC_BOVIN 100.000 0.535642 1.83209 CTRC - Chymotrypsin-C precursor - Bos taurus (Bovine) - CTRC gene Has chymotrypsin-type protease activity and hypocalcemic activity. Indicus|evm.model.CM009506.1.489 A5D7A0 EFHD2_BOVIN 99.587 0.991736 1 EFHD2 - EF-hand domain-containing protein D2 - Bos taurus (Bovine) - EFHD2 gene May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Indicus|evm.model.CM009506.1.490 B1AJZ9 FHAD1_HUMAN 72.211 0.959091 1.09065 FHAD1 - Forkhead-associated domain-containing protein 1 - Homo sapiens (Human) - FHAD1 gene Indicus|evm.model.CM009506.1.491 Q9NW97 TMM51_HUMAN 89.328 0.991968 0.98419 TMEM51 - Transmembrane protein 51 - Homo sapiens (Human) - TMEM51 gene Indicus|evm.model.CM009506.1.492 Q674X7 KAZRN_HUMAN 97.301 0.966988 0.938065 KAZN - Kazrin - Homo sapiens (Human) - KAZN gene Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. Indicus|evm.model.CM009506.1.494 Q674X7 KAZRN_HUMAN 82.609 0.497207 0.230968 KAZN - Kazrin - Homo sapiens (Human) - KAZN gene Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. Indicus|evm.model.CM009506.1.495 Q9ULL1 PKHG1_HUMAN 69.841 0.408497 0.220939 PLEKHG1 - Pleckstrin homology domain-containing family G member 1 - Homo sapiens (Human) - PLEKHG1 gene nucleoplasm Indicus|evm.model.CM009506.1.496 Q13029 PRDM2_HUMAN 84.884 0.998823 0.988941 PRDM2 - PR domain zinc finger protein 2 - Homo sapiens (Human) - PRDM2 gene S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. Indicus|evm.model.CM009506.1.497 Q9UGL1 KDM5B_HUMAN 91.938 0.946727 1.00907 KDM5B - Lysine-specific demethylase 5B - Homo sapiens (Human) - KDM5B gene Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). Indicus|evm.model.CM009506.1.499 A6H684 MGT4E_MOUSE 58.201 0.807775 1.05467 Mgat4e - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E - Mus musculus (Mouse) - Mgat4e gene Glycosyltransferase-like protein that may participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Indicus|evm.model.CM009506.1.500 P47224 MSS4_HUMAN 68.333 0.206823 3.81301 RABIF - Guanine nucleotide exchange factor MSS4 - Homo sapiens (Human) - RABIF gene Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein (PubMed:31540829). Might play a general role in vesicular transport. Indicus|evm.model.CM009506.1.501 Q53G59 KLH12_HUMAN 98.936 0.99646 0.994718 KLHL12 - Kelch-like protein 12 - Homo sapiens (Human) - KLHL12 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export (PubMed:27716508). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (PubMed:16547521). The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins (PubMed:18303015, PubMed:20100572, PubMed:27716508). Indicus|evm.model.CM009506.1.502 Q91VH1 PAQR1_MOUSE 97.067 0.994681 1.00267 Adipor1 - Adiponectin receptor protein 1 - Mus musculus (Mouse) - Adipor1 gene Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17268472, PubMed:24742672). Required for normal glucose and fat homeostasis and for maintaining a normal body weight (PubMed:17327425, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis (PubMed:12802337, PubMed:17327425, PubMed:17268472, PubMed:24742672). Has high affinity for globular adiponectin and low affinity for full-length adiponectin (PubMed:12802337). Indicus|evm.model.CM009506.1.503 Q3MHW9 NB5R1_BOVIN 100.000 0.821429 1.19344 CYB5R1 - NADH-cytochrome b5 reductase 1 - Bos taurus (Bovine) - CYB5R1 gene NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Indicus|evm.model.CM009506.1.505 Q5VT99 LRC38_HUMAN 93.711 0.365741 1.46939 LRRC38 - Leucine-rich repeat-containing protein 38 precursor - Homo sapiens (Human) - LRRC38 gene Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. Indicus|evm.model.CM009506.1.506 O95522 PRA12_HUMAN 53.263 0.980851 0.973085 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Indicus|evm.model.CM009506.1.507 P78395 PRAME_HUMAN 64.356 0.16955 1.13556 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009506.1.508 Q5VWM4 PRAM8_HUMAN 53.070 0.982646 0.972574 PRAMEF8 - PRAME family member 8 - Homo sapiens (Human) - PRAMEF8 gene cytoplasm Indicus|evm.model.CM009506.1.509 Q5VWM5 PRAM9_HUMAN 49.049 0.98829 0.893305 PRAMEF9 - PRAME family member 9/15 - Homo sapiens (Human) - PRAMEF9 gene cytoplasm Indicus|evm.model.CM009506.1.510 Q5VWM5 PRAM9_HUMAN 52.667 0.971554 0.956067 PRAMEF9 - PRAME family member 9/15 - Homo sapiens (Human) - PRAMEF9 gene cytoplasm Indicus|evm.model.CM009506.1.511 P78395 PRAME_HUMAN 52.490 0.972803 0.939096 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009506.1.512 Q5VWM5 PRAM9_HUMAN 49.731 0.942149 0.759414 PRAMEF9 - PRAME family member 9/15 - Homo sapiens (Human) - PRAMEF9 gene cytoplasm Indicus|evm.model.CM009506.1.513 Q5VWM5 PRAM9_HUMAN 53.265 0.934426 0.638075 PRAMEF9 - PRAME family member 9/15 - Homo sapiens (Human) - PRAMEF9 gene cytoplasm Indicus|evm.model.CM009506.1.514 Q5VWM5 PRAM9_HUMAN 56.881 0.972603 0.458159 PRAMEF9 - PRAME family member 9/15 - Homo sapiens (Human) - PRAMEF9 gene cytoplasm Indicus|evm.model.CM009506.1.515 Q5VWM4 PRAM8_HUMAN 48.773 0.915094 0.670886 PRAMEF8 - PRAME family member 8 - Homo sapiens (Human) - PRAMEF8 gene cytoplasm Indicus|evm.model.CM009506.1.516 O95522 PRA12_HUMAN 54.043 0.977035 0.991718 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Indicus|evm.model.CM009506.1.517 O95522 PRA12_HUMAN 52.871 0.974057 0.877847 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Indicus|evm.model.CM009506.1.518 P78395 PRAME_HUMAN 51.844 0.981172 0.939096 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009506.1.519 Q5VXH4 PRAM6_HUMAN 50.317 0.974948 1.0063 PRAMEF6 - PRAME family member 6 - Homo sapiens (Human) - PRAMEF6 gene cytoplasm Indicus|evm.model.CM009506.1.520 H0Y7S4 PRA26_HUMAN 54.468 0.829268 0.643979 PRAMEF26 - Putative PRAME family member 26 - Homo sapiens (Human) - PRAMEF26 gene cytoplasm Indicus|evm.model.CM009506.1.521 A3QJZ7 PRA27_HUMAN 56.608 0.994962 0.830544 PRAMEF27 - PRAME family member 27 - Homo sapiens (Human) - PRAMEF27 gene cytoplasm Indicus|evm.model.CM009506.1.522 O95522 PRA12_HUMAN 63.542 0.111502 1.76398 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Indicus|evm.model.CM009506.1.523 Q5VXH4 PRAM6_HUMAN 54.158 0.966527 1.0042 PRAMEF6 - PRAME family member 6 - Homo sapiens (Human) - PRAMEF6 gene cytoplasm Indicus|evm.model.CM009506.1.524 O95522 PRA12_HUMAN 51.592 0.993631 0.975155 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Indicus|evm.model.CM009506.1.525 O95522 PRA12_HUMAN 54.067 0.876068 0.484472 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Indicus|evm.model.CM009506.1.526 O95522 PRA12_HUMAN 51.282 0.87931 0.360248 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Indicus|evm.model.CM009506.1.527 Q60972 RBBP4_MOUSE 99.529 0.995305 1.00235 Rbbp4 - Histone-binding protein RBBP4 - Mus musculus (Mouse) - Rbbp4 gene Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Indicus|evm.model.CM009506.1.528 Q2TA11 CA158_BOVIN 98.980 0.989848 1.0051 Uncharacterized protein C1orf158 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009506.1.529 Q5VUY0 ADCL3_HUMAN 69.403 0.98044 1.00491 AADACL3 - Arylacetamide deacetylase-like 3 - Homo sapiens (Human) - AADACL3 gene hydrolase activity Indicus|evm.model.CM009506.1.530 Q5RFL9 NONO_PONAB 92.233 0.864407 0.250531 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009506.1.531 O77834 PRDX6_BOVIN 100.000 0.991111 1.00446 PRDX6 - Peroxiredoxin-6 - Bos taurus (Bovine) - PRDX6 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10409692, PubMed:2373154). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10409692). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10409692, PubMed:2373154, PubMed:9787801). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity). Indicus|evm.model.CM009506.1.532 Q5TZF3 ANR45_HUMAN 85.317 0.176636 5.34211 ANKRD45 - Ankyrin repeat domain-containing protein 45 - Homo sapiens (Human) - ANKRD45 gene Indicus|evm.model.CM009506.1.533 D3Z8N4 KLH20_RAT 100.000 0.996721 1.00164 Klhl20 - Kelch-like protein 20 - Rattus norvegicus (Rat) - Klhl20 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (By similarity). Indicus|evm.model.CM009506.1.534 Q5EA18 CENPL_BOVIN 100.000 0.994236 1.00289 CENPL - Centromere protein L - Bos taurus (Bovine) - CENPL gene Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity). Indicus|evm.model.CM009506.1.535 A6QPU5 SYDM_BOVIN 99.693 0.996933 1.00154 DARS2 - Aspartate--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - DARS2 gene aspartate-tRNA ligase activity, mitochondrial asparaginyl-tRNA aminoacylation Indicus|evm.model.CM009506.1.537 Q5TC79 ZBT37_HUMAN 97.813 0.996032 1.00199 ZBTB37 - Zinc finger and BTB domain-containing protein 37 - Homo sapiens (Human) - ZBTB37 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009506.1.538 P41361 ANT3_BOVIN 99.140 0.995708 1.00215 SERPINC1 - Antithrombin-III precursor - Bos taurus (Bovine) - SERPINC1 gene Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). Indicus|evm.model.CM009506.1.539 Q5TC82 RC3H1_HUMAN 98.261 0.985673 0.308032 RC3H1 - Roquin-1 - Homo sapiens (Human) - RC3H1 gene Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25504471, PubMed:25026078). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Indicus|evm.model.CM009506.1.541 Q5RCW6 RBG1L_PONAB 92.705 0.908587 0.442945 RABGAP1L - Rab GTPase-activating protein 1-like - Pongo abelii (Sumatran orangutan) - RABGAP1L gene GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). Indicus|evm.model.CM009506.1.542 Q5RCW6 RBG1L_PONAB 99.083 0.830769 0.159509 RABGAP1L - Rab GTPase-activating protein 1-like - Pongo abelii (Sumatran orangutan) - RABGAP1L gene GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). Indicus|evm.model.CM009506.1.543 A6QLE7 GPR52_BOVIN 99.723 0.994475 1.00277 GPR52 - G-protein coupled receptor 52 - Bos taurus (Bovine) - GPR52 gene G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum. Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation. Indicus|evm.model.CM009506.1.544 Q5RCW6 RBG1L_PONAB 98.052 0.757426 0.247853 RABGAP1L - Rab GTPase-activating protein 1-like - Pongo abelii (Sumatran orangutan) - RABGAP1L gene GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). Indicus|evm.model.CM009506.1.545 Q5R372 RBG1L_HUMAN 98.701 0.218391 0.426994 RABGAP1L - Rab GTPase-activating protein 1-like - Homo sapiens (Human) - RABGAP1L gene GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). Indicus|evm.model.CM009506.1.546 Q3T168 CYBP_BOVIN 100.000 0.991342 1.00435 CACYBP - Calcyclin-binding protein - Bos taurus (Bovine) - CACYBP gene May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). Indicus|evm.model.CM009506.1.547 Q6B860 RT14_BOVIN 100.000 0.984496 1.00781 MRPS14 - 28S ribosomal protein S14, mitochondrial - Bos taurus (Bovine) - MRPS14 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit, structural constituent of ribosome, mitochondrial translation, translation Indicus|evm.model.CM009506.1.548 Q9UQP3 TENN_HUMAN 80.453 0.761733 1.0662 TNN - Tenascin-N precursor - Homo sapiens (Human) - TNN gene Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022). Indicus|evm.model.CM009506.1.549 Q15053 K0040_HUMAN 80.000 0.980198 1.0202 KIAA0040 - Uncharacterized protein KIAA0040 - Homo sapiens (Human) - KIAA0040 gene Indicus|evm.model.CM009506.1.550 Q92752 TENR_HUMAN 91.311 0.998495 0.978645 TNR - Tenascin-R precursor - Homo sapiens (Human) - TNR gene Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). Indicus|evm.model.CM009506.1.551 Q9R1A8 COP1_MOUSE 99.664 0.962723 0.841746 Cop1 - E3 ubiquitin-protein ligase COP1 - Mus musculus (Mouse) - Cop1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif. Indicus|evm.model.CM009506.1.552 Q9BXP8 PAPP2_HUMAN 63.844 0.968153 0.175321 PAPPA2 - Pappalysin-2 precursor - Homo sapiens (Human) - PAPPA2 gene Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. Indicus|evm.model.CM009506.1.553 Q9BXP8 PAPP2_HUMAN 81.036 0.836834 0.691234 PAPPA2 - Pappalysin-2 precursor - Homo sapiens (Human) - PAPPA2 gene Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. Indicus|evm.model.CM009506.1.554 Q9BXP8 PAPP2_HUMAN 91.071 0.948276 0.0323841 PAPPA2 - Pappalysin-2 precursor - Homo sapiens (Human) - PAPPA2 gene Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. Indicus|evm.model.CM009506.1.555 O14525 ASTN1_HUMAN 97.342 0.574056 0.793395 ASTN1 - Astrotactin-1 precursor - Homo sapiens (Human) - ASTN1 gene Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development. Indicus|evm.model.CM009506.1.557 Q5RDR5 BRNP2_PONAB 87.500 0.997234 0.923372 BRINP2 - BMP/retinoic acid-inducible neural-specific protein 2 precursor - Pongo abelii (Sumatran orangutan) - BRINP2 gene Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Indicus|evm.model.CM009506.1.559 P10575 GLRX1_BOVIN 98.113 0.981308 1.00943 GLRX - Glutaredoxin-1 - Bos taurus (Bovine) - GLRX gene Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Indicus|evm.model.CM009506.1.560 Q75NY9 SC16B_BOVIN 96.679 0.998104 1.00285 SEC16B - Protein transport protein Sec16B - Bos taurus (Bovine) - SEC16B gene Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes. Indicus|evm.model.CM009506.1.561 A6QQF5 QORL2_BOVIN 100.000 0.994286 1.00287 Quinone oxidoreductase-like protein 2 - Bos taurus (Bovine) Indicus|evm.model.CM009506.1.562 Q9UJF2 NGAP_HUMAN 97.459 0.865317 0.997366 RASAL2 - Ras GTPase-activating protein nGAP - Homo sapiens (Human) - RASAL2 gene Inhibitory regulator of the Ras-cyclic AMP pathway. Indicus|evm.model.CM009506.1.563 Q6ZU45 CL20A_HUMAN 56.098 0.126562 1.6 CLEC20A - Putative C-type lectin domain family 20 member A precursor - Homo sapiens (Human) - CLEC20A gene Indicus|evm.model.CM009506.1.564 Q2YDP6 TEX35_BOVIN 99.052 0.990566 1.00474 Tex35 - Testis-expressed protein 35 - Bos taurus (Bovine) - Tex35 gene nucleus Indicus|evm.model.CM009506.1.567 Q86X27 RGPS2_HUMAN 98.971 0.996575 1.00172 RALGPS2 - Ras-specific guanine nucleotide-releasing factor RalGPS2 - Homo sapiens (Human) - RALGPS2 gene Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). Indicus|evm.model.CM009506.1.568 O75063 XYLK_HUMAN 97.555 0.995122 1.00244 FAM20B - Glycosaminoglycan xylosylkinase - Homo sapiens (Human) - FAM20B gene Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized. Indicus|evm.model.CM009506.1.569 Q9H497 TOR3A_HUMAN 76.075 0.920596 1.01511 TOR3A - Torsin-3A precursor - Homo sapiens (Human) - TOR3A gene endoplasmic reticulum, endoplasmic reticulum lumen, extracellular exosome, nuclear envelope, ATPase activity Indicus|evm.model.CM009506.1.570 P42684 ABL2_HUMAN 96.024 0.998309 1.00085 ABL2 - Tyrosine-protein kinase ABL2 - Homo sapiens (Human) - ABL2 gene Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Indicus|evm.model.CM009506.1.571 O77760 SOAT1_CHLAE 85.481 0.994565 1.00364 SOAT1 - Sterol O-acyltransferase 1 - Chlorocebus aethiops (Green monkey) - SOAT1 gene Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions. Indicus|evm.model.CM009506.1.572 Q95LP5 AXDN1_MACFA 76.634 0.793605 1.20702 AXDND1 - Axonemal dynein light chain domain-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - AXDND1 gene Indicus|evm.model.CM009506.1.573 Q9NP85 PODO_HUMAN 90.959 0.947917 1.00261 NPHS2 - Podocin - Homo sapiens (Human) - NPHS2 gene Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. Indicus|evm.model.CM009506.1.574 E1BPH3 TDRD5_BOVIN 88.772 0.998077 1.06667 TDRD5 - Tudor domain-containing protein 5 - Bos taurus (Bovine) - TDRD5 gene Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity). Indicus|evm.model.CM009506.1.575 Q96GL9 F163A_HUMAN 91.018 0.988095 1.00599 FAM163A - Protein FAM163A - Homo sapiens (Human) - FAM163A gene Indicus|evm.model.CM009506.1.576 Q8NFQ8 TOIP2_HUMAN 74.364 0.995745 1 TOR1AIP2 - Torsin-1A-interacting protein 2 - Homo sapiens (Human) - TOR1AIP2 gene Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. Indicus|evm.model.CM009506.1.578 F1N4E5 TOIP1_BOVIN 94.797 0.996672 1.00167 TOR1AIP1 - Torsin-1A-interacting protein 1 - Bos taurus (Bovine) - TOR1AIP1 gene Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina (By similarity). Indicus|evm.model.CM009506.1.579 Q5VT06 CE350_HUMAN 86.669 0.999359 1.00096 CEP350 - Centrosome-associated protein 350 - Homo sapiens (Human) - CEP350 gene Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). Indicus|evm.model.CM009506.1.580 O00391 QSOX1_HUMAN 76.950 0.923841 0.808568 QSOX1 - Sulfhydryl oxidase 1 precursor - Homo sapiens (Human) - QSOX1 gene Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277). Indicus|evm.model.CM009506.1.581 P53776 LHX4_MOUSE 99.487 0.994885 1.00256 Lhx4 - LIM/homeobox protein Lhx4 - Mus musculus (Mouse) - Lhx4 gene May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (By similarity). Indicus|evm.model.CM009506.1.582 A2VDR2 ACBD6_BOVIN 100.000 0.735294 0.241135 ACBD6 - Acyl-CoA-binding domain-containing protein 6 - Bos taurus (Bovine) - ACBD6 gene Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids (By similarity). Indicus|evm.model.CM009506.1.583 A2VDR2 ACBD6_BOVIN 100.000 0.995475 0.783688 ACBD6 - Acyl-CoA-binding domain-containing protein 6 - Bos taurus (Bovine) - ACBD6 gene Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids (By similarity). Indicus|evm.model.CM009506.1.584 Q9UBH6 XPR1_HUMAN 96.264 0.997131 1.00144 XPR1 - Xenotropic and polytropic retrovirus receptor 1 - Homo sapiens (Human) - XPR1 gene Plays a role in phosphate homeostasis. Mediates phosphate export from the cell (PubMed:23791524, PubMed:25938945). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106). Indicus|evm.model.CM009506.1.585 Q5VZ46 K1614_HUMAN 62.415 0.946399 1.00336 KIAA1614 - Uncharacterized protein KIAA1614 - Homo sapiens (Human) - KIAA1614 gene apical plasma membrane, cell cortex, nucleus, protein kinase C binding, centrosome cycle, establishment or maintenance of cell polarity, regulation of cellular localization Indicus|evm.model.CM009506.1.586 Q5R6Q2 STX6_PONAB 89.804 0.991597 0.933333 STX6 - Syntaxin-6 - Pongo abelii (Sumatran orangutan) - STX6 gene Involved in intracellular vesicle trafficking. Indicus|evm.model.CM009506.1.587 C1ITJ8 HMR1_BOVIN 98.810 0.994065 1.00298 MR1 - Major histocompatibility complex class I-related gene protein precursor - Bos taurus (Bovine) - MR1 gene Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (By similarity). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (By similarity). May present microbial antigens to various MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity). Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity). Indicus|evm.model.CM009506.1.588 Q5VY09 IER5_HUMAN 74.468 0.993846 0.993884 IER5 - Immediate early response gene 5 protein - Homo sapiens (Human) - IER5 gene Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193). Indicus|evm.model.CM009506.1.590 Q61290 CAC1E_MOUSE 93.000 0.590062 0.0708627 Cacna1e - Voltage-dependent R-type calcium channel subunit alpha-1E - Mus musculus (Mouse) - Cacna1e gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Indicus|evm.model.CM009506.1.591 Q15878 CAC1E_HUMAN 100.000 0.371981 0.0894942 CACNA1E - Voltage-dependent R-type calcium channel subunit alpha-1E - Homo sapiens (Human) - CACNA1E gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Indicus|evm.model.CM009506.1.592 Q15878 CAC1E_HUMAN 98.649 0.849711 0.0747946 CACNA1E - Voltage-dependent R-type calcium channel subunit alpha-1E - Homo sapiens (Human) - CACNA1E gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Indicus|evm.model.CM009506.1.593 Q15878 CAC1E_HUMAN 95.978 0.994402 0.849546 CACNA1E - Voltage-dependent R-type calcium channel subunit alpha-1E - Homo sapiens (Human) - CACNA1E gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Indicus|evm.model.CM009506.1.594 Q5T619 ZN648_HUMAN 73.723 0.996283 0.947183 ZNF648 - Zinc finger protein 648 - Homo sapiens (Human) - ZNF648 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009506.1.595 P84089 ERH_MOUSE 97.222 0.972603 0.701923 Erh - Enhancer of rudimentary homolog - Mus musculus (Mouse) - Erh gene May have a role in the cell cycle. Indicus|evm.model.CM009506.1.596 A6H767 NP1L1_BOVIN 99.174 0.942708 0.982097 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009506.1.597 P15103 GLNA_BOVIN 100.000 0.494024 2.01877 GLUL - Glutamine synthetase - Bos taurus (Bovine) - GLUL gene Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Indicus|evm.model.CM009506.1.598 A5PLK6 RGSL_HUMAN 71.724 0.9973 1.03253 RGSL1 - Regulator of G-protein signaling protein-like - Homo sapiens (Human) - RGSL1 gene Indicus|evm.model.CM009506.1.599 Q05823 RN5A_HUMAN 71.547 0.993094 0.977058 RNASEL - 2-5A-dependent ribonuclease - Homo sapiens (Human) - RNASEL gene Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length. Indicus|evm.model.CM009506.1.600 O46471 RGS16_BOVIN 100.000 0.990148 1.00495 RGS16 - Regulator of G-protein signaling 16 - Bos taurus (Bovine) - RGS16 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals. Indicus|evm.model.CM009506.1.601 P49804 RGS8_RAT 99.444 0.98895 1.00556 Rgs8 - Regulator of G-protein signaling 8 - Rattus norvegicus (Rat) - Rgs8 gene Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling. Indicus|evm.model.CM009506.1.602 Q29RY9 NPL_BOVIN 100.000 0.993769 1.00313 NPL - N-acetylneuraminate lyase - Bos taurus (Bovine) - NPL gene Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). Indicus|evm.model.CM009506.1.604 Q28141 DHX9_BOVIN 99.845 0.998447 1.00078 DHX9 - ATP-dependent RNA helicase A - Bos taurus (Bovine) - DHX9 gene Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:7511411). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:7511411). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:7511411). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:7511411). Binds also to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A. Plays a role in DNA replication at origins of replication and cell cycle progression. Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1. Binds to the CDKN2A promoter. Plays several roles in post-transcriptional regulation of gene expression. In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes. As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Acts also as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition. Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA. Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability. Plays a role in mRNA translation. Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs. Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation. Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process. Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection. This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis. Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus. Indicus|evm.model.CM009506.1.605 Q3TTP0 SHP1L_MOUSE 91.468 0.504318 0.906103 Shcbp1l - Testicular spindle-associated protein SHCBP1L - Mus musculus (Mouse) - Shcbp1l gene Testis-specific spindle-associated factor that plays a role in spermatogenesis (PubMed:24557841). In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells (PubMed:24557841). Indicus|evm.model.CM009506.1.606 P11047 LAMC1_HUMAN 94.469 0.998757 1 LAMC1 - Laminin subunit gamma-1 precursor - Homo sapiens (Human) - LAMC1 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Indicus|evm.model.CM009506.1.607 Q8HZI9 LAMC2_HORSE 86.577 0.998322 1.00168 LAMC2 - Laminin subunit gamma-2 precursor - Equus caballus (Horse) - LAMC2 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. Indicus|evm.model.CM009506.1.608 Q0VC59 NMNA2_BOVIN 100.000 0.876791 1.13681 NMNAT2 - Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 - Bos taurus (Bovine) - NMNAT2 gene Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Indicus|evm.model.CM009506.1.609 Q5RJH6 SMG7_MOUSE 94.829 0.998249 1.00351 Smg7 - Protein SMG7 - Mus musculus (Mouse) - Smg7 gene Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). Indicus|evm.model.CM009506.1.610 O77775 NCF2_BOVIN 99.810 0.996212 1.0019 NCF2 - Neutrophil cytosol factor 2 - Bos taurus (Bovine) - NCF2 gene NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Indicus|evm.model.CM009506.1.611 Q9CPW4 ARPC5_MOUSE 100.000 0.980392 0.675497 Arpc5 - Actin-related protein 2/3 complex subunit 5 - Mus musculus (Mouse) - Arpc5 gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Indicus|evm.model.CM009506.1.612 Q4KLF8 ARPC5_RAT 100.000 0.313333 0.993377 Arpc5 - Actin-related protein 2/3 complex subunit 5 - Rattus norvegicus (Rat) - Arpc5 gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Indicus|evm.model.CM009506.1.613 Q8WW27 ABEC4_HUMAN 80.223 0.97019 1.00545 APOBEC4 - Putative C->U-editing enzyme APOBEC-4 - Homo sapiens (Human) - APOBEC4 gene Putative C to U editing enzyme whose physiological substrate is not yet known. Indicus|evm.model.CM009506.1.614 Q9NZL6 RGL1_HUMAN 96.574 0.942786 1.04688 RGL1 - Ral guanine nucleotide dissociation stimulator-like 1 - Homo sapiens (Human) - RGL1 gene Probable guanine nucleotide exchange factor. Indicus|evm.model.CM009506.1.615 Q8IYK4 GT252_HUMAN 94.981 0.948763 0.904153 COLGALT2 - Procollagen galactosyltransferase 2 precursor - Homo sapiens (Human) - COLGALT2 gene Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen. Indicus|evm.model.CM009506.1.616 Q8R3W5 SEN15_MOUSE 88.690 0.988166 1.00595 Tsen15 - tRNA-splicing endonuclease subunit Sen15 - Mus musculus (Mouse) - Tsen15 gene Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity). Indicus|evm.model.CM009506.1.617 Q9H246 CA021_HUMAN 99.174 0.983607 1.00826 C1orf21 - Uncharacterized protein C1orf21 - Homo sapiens (Human) - C1orf21 gene Indicus|evm.model.CM009506.1.618 Q9BZQ6 EDEM3_HUMAN 95.927 0.997854 1 EDEM3 - ER degradation-enhancing alpha-mannosidase-like protein 3 precursor - Homo sapiens (Human) - EDEM3 gene Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity). Indicus|evm.model.CM009506.1.619 Q9BZQ8 NIBA1_HUMAN 75.844 0.997859 1.00647 NIBAN1 - Protein Niban 1 - Homo sapiens (Human) - NIBAN1 gene Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). Indicus|evm.model.CM009506.1.621 Q9CQJ4 RING2_MOUSE 99.702 0.994065 1.00298 Rnf2 - E3 ubiquitin-protein ligase RING2 - Mus musculus (Mouse) - Rnf2 gene E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15525528, PubMed:22325148, PubMed:28596365). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals (PubMed:15525528, PubMed:28596365). May be involved in the initiation of both imprinted and random X inactivation (PubMed:15525528). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:22325148, PubMed:16710298). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:15525528, PubMed:22325148, PubMed:16710298). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:16710298). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (PubMed:15525528, PubMed:16710298). Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers (PubMed:22226355). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Indicus|evm.model.CM009506.1.622 A5D7S3 TRM1L_BOVIN 93.622 0.997452 1.06513 TRMT1L - TRMT1-like protein - Bos taurus (Bovine) - TRMT1L gene May play a role in motor coordination and exploratory behavior. Indicus|evm.model.CM009506.1.623 Q5T5J6 SWT1_HUMAN 78.808 0.996678 1.00333 SWT1 - Transcriptional protein SWT1 - Homo sapiens (Human) - SWT1 gene nucleus Indicus|evm.model.CM009506.1.624 Q920Q8 NS1BP_MOUSE 97.196 0.99689 1.00156 Ivns1abp - Influenza virus NS1A-binding protein homolog - Mus musculus (Mouse) - Ivns1abp gene Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (PubMed:12213805, PubMed:16317045). Protects cells from cell death induced by actin destabilization (PubMed:16952015). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (By similarity). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (By similarity). Inhibits pre-mRNA splicing (in vitro) (By similarity). Indicus|evm.model.CM009506.1.625 P18621 RL17_HUMAN 83.582 0.496241 0.722826 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009506.1.626 Q8N5G0 SIM20_HUMAN 100.000 0.970588 1.01493 SMIM20 - Small integral membrane protein 20 - Homo sapiens (Human) - SMIM20 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (PubMed:26321642). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (PubMed:26321642). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (PubMed:26321642). Indicus|evm.model.CM009506.1.627 Q96RW7 HMCN1_HUMAN 89.346 0.96896 0.926176 HMCN1 - Hemicentin-1 precursor - Homo sapiens (Human) - HMCN1 gene Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration. Indicus|evm.model.CM009506.1.628 Q9JM99 PRG4_MOUSE 72.810 0.221024 1.40797 Prg4 - Proteoglycan 4 precursor - Mus musculus (Mouse) - Prg4 gene Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Indicus|evm.model.CM009506.1.629 P12270 TPR_HUMAN 96.191 0.967993 1.03132 TPR - Nucleoprotein TPR - Homo sapiens (Human) - TPR gene Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. Indicus|evm.model.CM009506.1.630 Q5SWX8 ODR4_HUMAN 88.377 0.995624 1.00661 ODR4 - Protein odr-4 homolog - Homo sapiens (Human) - ODR4 gene May play a role in the trafficking of a subset of G-protein coupled receptors. Indicus|evm.model.CM009506.1.631 P19632 PHOS_BOVIN 99.184 0.99187 1.00408 PDC - Phosducin - Bos taurus (Bovine) - PDC gene Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Indicus|evm.model.CM009506.1.632 O62698 PGH2_BOVIN 99.669 0.996694 1.00166 PTGS2 - Prostaglandin G/H synthase 2 precursor - Bos taurus (Bovine) - PTGS2 gene Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S-RvE2. In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection. In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11-diHETE) (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (By similarity). Indicus|evm.model.CM009506.1.633 P10853 H2B1F_MOUSE 66.667 0.978261 0.730159 H2bc7 - Histone H2B type 1-F/J/L - Mus musculus (Mouse) - H2bc7 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009506.1.634 A4IFJ5 PA24A_BOVIN 100.000 0.997294 0.986649 PLA2G4A - Cytosolic phospholipase A2 - Bos taurus (Bovine) - PLA2G4A gene Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (By similarity). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity). Indicus|evm.model.CM009506.1.635 Q66K74 MAP1S_HUMAN 65.556 0.85 0.0944287 MAP1S - Microtubule-associated protein 1S - Homo sapiens (Human) - MAP1S gene Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). Indicus|evm.model.CM009506.1.636 O95069 KCNK2_HUMAN 97.393 0.789474 1.24883 KCNK2 - Potassium channel subfamily K member 2 - Homo sapiens (Human) - KCNK2 gene Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Indicus|evm.model.CM009506.1.637 P49454 CENPF_HUMAN 73.214 0.308896 1.04689 CENPF - Centromere protein F precursor - Homo sapiens (Human) - CENPF gene Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia. Indicus|evm.model.CM009506.1.638 Q15678 PTN14_HUMAN 94.958 0.998321 1.00337 PTPN14 - Tyrosine-protein phosphatase non-receptor type 14 - Homo sapiens (Human) - PTPN14 gene Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. Indicus|evm.model.CM009506.1.639 Q0P585 SMYD2_BOVIN 94.472 0.977833 0.937644 SMYD2 - N-lysine methyltransferase SMYD2 - Bos taurus (Bovine) - SMYD2 gene Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. Indicus|evm.model.CM009506.1.640 Q9H4A4 AMPB_HUMAN 79.600 0.928429 0.773846 RNPEP - Aminopeptidase B - Homo sapiens (Human) - RNPEP gene Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). Indicus|evm.model.CM009506.1.641 P78545 ELF3_HUMAN 81.183 0.984085 1.01617 ELF3 - ETS-related transcription factor Elf-3 - Homo sapiens (Human) - ELF3 gene Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). Indicus|evm.model.CM009506.1.642 Q17QD8 G37L1_BOVIN 98.963 0.995825 0.993776 GPR37L1 - G-protein coupled receptor 37-like 1 precursor - Bos taurus (Bovine) - GPR37L1 gene G-protein coupled receptor (By similarity). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). Indicus|evm.model.CM009506.1.643 Q5ZKQ8 ARL8A_CHICK 100.000 0.988024 0.897849 ARL8A - ADP-ribosylation factor-like protein 8A - Gallus gallus (Chicken) - ARL8A gene Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity). Indicus|evm.model.CM009506.1.644 P35236 PTN7_HUMAN 89.049 0.353783 2.71667 PTPN7 - Tyrosine-protein phosphatase non-receptor type 7 - Homo sapiens (Human) - PTPN7 gene Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. Indicus|evm.model.CM009506.1.645 Q64612 PTPRV_RAT 63.340 0.986341 0.599065 Ptprv - Receptor-type tyrosine-protein phosphatase V precursor - Rattus norvegicus (Rat) - Ptprv gene May function in signaling pathways during bone remodeling, as well as serve a broader role in cell interactions associated with differentiation in bone and testis. Associated with differentiation in bone and testis. Indicus|evm.model.CM009506.1.646 Q9HBX8 LGR6_HUMAN 77.778 0.706494 0.796277 LGR6 - Leucine-rich repeat-containing G-protein coupled receptor 6 precursor - Homo sapiens (Human) - LGR6 gene Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. Indicus|evm.model.CM009506.1.647 Q32LD2 UBE2T_BOVIN 99.487 0.989796 1.00513 UBE2T - Ubiquitin-conjugating enzyme E2 T - Bos taurus (Bovine) - UBE2T gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Indicus|evm.model.CM009506.1.650 Q8BG95 MYPT2_MOUSE 78.697 0.796897 0.726434 Ppp1r12b - Protein phosphatase 1 regulatory subunit 12B - Mus musculus (Mouse) - Ppp1r12b gene Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus (By similarity). Indicus|evm.model.CM009506.1.652 P29101 SYT2_RAT 99.342 0.622177 1.15403 Syt2 - Synaptotagmin-2 - Rattus norvegicus (Rat) - Syt2 gene Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes. Indicus|evm.model.CM009506.1.653 Q92786 PROX1_HUMAN 91.497 0.997465 1.07056 PROX1 - Prospero homeobox protein 1 - Homo sapiens (Human) - PROX1 gene Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. Indicus|evm.model.CM009506.1.655 Q96S38 KS6C1_HUMAN 89.035 0.998117 0.996248 RPS6KC1 - Ribosomal protein S6 kinase delta-1 - Homo sapiens (Human) - RPS6KC1 gene May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). Indicus|evm.model.CM009506.1.656 A6H7I3 ANGE2_BOVIN 99.816 0.99633 1.00184 ANGEL2 - Protein angel homolog 2 - Bos taurus (Bovine) - ANGEL2 gene 3'-5'-exoribonuclease activity, mRNA 3'-UTR binding, 3'-UTR-mediated mRNA stabilization Indicus|evm.model.CM009506.1.657 Q86V25 VASH2_HUMAN 98.592 0.994382 1.00282 VASH2 - Tubulinyl-Tyr carboxypeptidase 2 - Homo sapiens (Human) - VASH2 gene Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911). Indicus|evm.model.CM009506.1.658 Q9Y5Y0 FLVC1_HUMAN 86.257 0.827586 1.2018 FLVCR1 - Feline leukemia virus subgroup C receptor-related protein 1 - Homo sapiens (Human) - FLVCR1 gene Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro. Indicus|evm.model.CM009506.1.659 A1A4M4 TATD3_BOVIN 100.000 0.992701 1.00366 TATDN3 - Putative deoxyribonuclease TATDN3 - Bos taurus (Bovine) - TATDN3 gene Putative deoxyribonuclease. Indicus|evm.model.CM009506.1.660 Q96IY1 NSL1_HUMAN 81.752 0.968085 1.00356 NSL1 - Kinetochore-associated protein NSL1 homolog - Homo sapiens (Human) - NSL1 gene Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. Indicus|evm.model.CM009506.1.662 Q9NR55 BATF3_HUMAN 90.722 0.347985 2.14961 BATF3 - Basic leucine zipper transcriptional factor ATF-like 3 - Homo sapiens (Human) - BATF3 gene AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Indicus|evm.model.CM009506.1.663 Q66H38 FA71B_RAT 64.609 0.411263 0.905719 Fam71b - Protein FAM71B - Rattus norvegicus (Rat) - Fam71b gene May be involved in RNA biogenesis. Indicus|evm.model.CM009506.1.664 Q2KII1 ATF3_BOVIN 100.000 0.714286 1.39227 ATF3 - Cyclic AMP-dependent transcription factor ATF-3 - Bos taurus (Bovine) - ATF3 gene This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites (By similarity). It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity). Indicus|evm.model.CM009506.1.665 Q1JQA5 NENF_BOVIN 99.259 0.943662 0.840237 NENF - Neudesin precursor - Bos taurus (Bovine) - NENF gene Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (By similarity). Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Indicus|evm.model.CM009506.1.666 Q2KHV2 PACC1_BOVIN 99.714 0.994302 1.00286 PACC1 - Proton-activated chloride channel - Bos taurus (Bovine) - PACC1 gene Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling. Indicus|evm.model.CM009506.1.667 Q15172 2A5A_HUMAN 98.152 0.991837 1.00823 PPP2R5A - Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform - Homo sapiens (Human) - PPP2R5A gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Indicus|evm.model.CM009506.1.668 Q9NZJ0 DTL_HUMAN 90.685 0.997264 1.00137 DTL - Denticleless protein homolog - Homo sapiens (Human) - DTL gene Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). Indicus|evm.model.CM009506.1.669 Q1RMS6 INT7_BOVIN 100.000 0.997923 1.00104 INTS7 - Integrator complex subunit 7 - Bos taurus (Bovine) - INTS7 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. Indicus|evm.model.CM009506.1.670 Q92604 LGAT1_HUMAN 91.081 0.994609 1.0027 LPGAT1 - Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 - Homo sapiens (Human) - LPGAT1 gene Catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylglycerol (LPG) leading to biosynthesis of phosphatidylglycerol, a precursor for cardiolipin synthesis (PubMed:15485873). Uses various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors (PubMed:15485873). Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor (PubMed:15485873). In vitro can also catalyzes the transfert of an acyl group from an acyl-CoA to a monoacylglycerol leading to diacylglycerol synthesis, a precursor of triacylglycerol and plays a role in hepatic triacylglycerol synthesis and secretion (By similarity). Prefers the sn-2-monoacylglycerol to rac-1-monoacylglycerol as acyl acceptor (By similarity). Indicus|evm.model.CM009506.1.671 P51955 NEK2_HUMAN 92.809 0.995516 1.00225 NEK2 - Serine/threonine-protein kinase Nek2 - Homo sapiens (Human) - NEK2 gene Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Indicus|evm.model.CM009506.1.673 Q4R6K2 ZNT1_MACFA 88.757 0.996055 1.00396 SLC30A1 - Zinc transporter 1 - Macaca fascicularis (Crab-eating macaque) - SLC30A1 gene May be involved in zinc transport out of the cell. Indicus|evm.model.CM009506.1.674 Q7Z3Z2 RD3_HUMAN 82.653 0.989796 1.00513 RD3 - Protein RD3 - Homo sapiens (Human) - RD3 gene Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:29515371, PubMed:21928830, PubMed:21078983, PubMed:27471269, PubMed:30559291). Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors (PubMed:21928830, PubMed:27471269, PubMed:29515371, PubMed:30559291). Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment (PubMed:21078983). Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP (PubMed:29515371). Plays an important role for the survival of rods and cones in the retina (By similarity). Indicus|evm.model.CM009506.1.675 Q9P2K3 RCOR3_HUMAN 99.120 0.371179 1.85051 RCOR3 - REST corepressor 3 - Homo sapiens (Human) - RCOR3 gene May act as a component of a corepressor complex that represses transcription. Indicus|evm.model.CM009506.1.677 O18965 KCNH1_BOVIN 100.000 0.958101 0.362715 KCNH1 - Potassium voltage-gated channel subfamily H member 1 - Bos taurus (Bovine) - KCNH1 gene Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9524140). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity). Indicus|evm.model.CM009506.1.678 Q63472 KCNH1_RAT 90.041 0.83045 0.300416 Kcnh1 - Potassium voltage-gated channel subfamily H member 1 - Rattus norvegicus (Rat) - Kcnh1 gene Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:7925287, PubMed:9400421, PubMed:24495567, PubMed:27516594). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity). Indicus|evm.model.CM009506.1.679 O18965 KCNH1_BOVIN 100.000 0.841791 0.339412 KCNH1 - Potassium voltage-gated channel subfamily H member 1 - Bos taurus (Bovine) - KCNH1 gene Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9524140). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity). Indicus|evm.model.CM009506.1.680 Q5VTY9 HHAT_HUMAN 85.475 0.777293 0.464503 HHAT - Protein-cysteine N-palmitoyltransferase HHAT - Homo sapiens (Human) - HHAT gene Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP. Indicus|evm.model.CM009506.1.681 Q9NUC0 SRTD4_HUMAN 92.135 0.994334 0.991573 SERTAD4 - SERTA domain-containing protein 4 - Homo sapiens (Human) - SERTAD4 gene Indicus|evm.model.CM009506.1.682 Q8NB59 SYT14_HUMAN 97.495 0.603535 1.42703 SYT14 - Synaptotagmin-14 - Homo sapiens (Human) - SYT14 gene May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. Indicus|evm.model.CM009506.1.683 Q68CQ4 DIEXF_HUMAN 91.566 0.835771 1.17593 UTP25 - U3 small nucleolar RNA-associated protein 25 homolog - Homo sapiens (Human) - UTP25 gene Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:25007945, PubMed:27657329, PubMed:23357851). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). Indicus|evm.model.CM009506.1.684 Q08DD6 IRF6_BOVIN 100.000 0.995726 1.00214 IRF6 - Interferon regulatory factor 6 - Bos taurus (Bovine) - IRF6 gene Probable DNA-binding transcriptional activator. It is a key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). Indicus|evm.model.CM009506.1.685 A6QQA5 CA074_BOVIN 99.620 0.992424 1.0038 UPF0739 protein C1orf74 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009506.1.686 Q9Y228 T3JAM_HUMAN 84.448 0.994595 1.00726 TRAF3IP3 - TRAF3-interacting JNK-activating modulator - Homo sapiens (Human) - TRAF3IP3 gene Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Plays also an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed:32366851). Indicus|evm.model.CM009506.1.687 P51975 DHI1_SHEEP 94.863 0.993174 1.00342 HSD11B1 - Corticosteroid 11-beta-dehydrogenase isozyme 1 - Ovis aries (Sheep) - HSD11B1 gene Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone (By similarity). Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity). Indicus|evm.model.CM009506.1.688 P27469 G0S2_HUMAN 63.107 0.979798 0.961165 G0S2 - G0/G1 switch protein 2 - Homo sapiens (Human) - G0S2 gene Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. Indicus|evm.model.CM009506.1.689 Q13751 LAMB3_HUMAN 84.044 0.998295 1.00085 LAMB3 - Laminin subunit beta-3 precursor - Homo sapiens (Human) - LAMB3 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Indicus|evm.model.CM009506.1.690 Q96NX5 KCC1G_HUMAN 92.034 0.995789 0.997899 CAMK1G - Calcium/calmodulin-dependent protein kinase type 1G - Homo sapiens (Human) - CAMK1G gene Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity). Indicus|evm.model.CM009506.1.692 O75051 PLXA2_HUMAN 92.100 0.97551 0.258712 PLXNA2 - Plexin-A2 precursor - Homo sapiens (Human) - PLXNA2 gene Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). Indicus|evm.model.CM009506.1.693 O75051 PLXA2_HUMAN 99.674 0.19883 0.812566 PLXNA2 - Plexin-A2 precursor - Homo sapiens (Human) - PLXNA2 gene Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). Indicus|evm.model.CM009506.1.694 Q28270 CD34_CANLF 65.789 0.963446 0.984576 CD34 - Hematopoietic progenitor cell antigen CD34 precursor - Canis lupus familiaris (Dog) - CD34 gene Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). Indicus|evm.model.CM009506.1.698 Q6VE48 MCP_BOVIN 88.976 0.938119 1.11911 CD46 - Membrane cofactor protein precursor - Bos taurus (Bovine) - CD46 gene Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells. Indicus|evm.model.CM009506.1.699 Q6VE48 MCP_BOVIN 50.988 0.426945 1.45983 CD46 - Membrane cofactor protein precursor - Bos taurus (Bovine) - CD46 gene Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells. Indicus|evm.model.CM009506.1.700 Q6VE48 MCP_BOVIN 46.857 0.729614 1.29086 CD46 - Membrane cofactor protein precursor - Bos taurus (Bovine) - CD46 gene Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells. Indicus|evm.model.CM009506.1.701 P36980 FHR2_HUMAN 60.223 0.960573 1.03333 CFHR2 - Complement factor H-related protein 2 precursor - Homo sapiens (Human) - CFHR2 gene Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. Indicus|evm.model.CM009506.1.702 P05160 F13B_HUMAN 75.077 0.491667 1.99697 F13B - Coagulation factor XIII B chain precursor - Homo sapiens (Human) - F13B gene The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Indicus|evm.model.CM009506.1.703 P62285 ASPM_BOVIN 97.776 0.973333 1.02344 ASPM - Abnormal spindle-like microcephaly-associated protein homolog - Bos taurus (Bovine) - ASPM gene Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). Indicus|evm.model.CM009506.1.704 Q5SVQ8 ZBT41_HUMAN 96.702 0.997006 0.734873 ZBTB41 - Zinc finger and BTB domain-containing protein 41 - Homo sapiens (Human) - ZBTB41 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009506.1.705 P82279 CRUM1_HUMAN 71.662 0.998581 1.00213 CRB1 - Protein crumbs homolog 1 precursor - Homo sapiens (Human) - CRB1 gene Plays a role in photoreceptor morphogenesis in the retina (By similarity). May maintain cell polarization and adhesion (By similarity). Indicus|evm.model.CM009506.1.707 Q6P3S1 DEN1B_HUMAN 79.358 0.965957 0.909677 DENND1B - DENN domain-containing protein 1B - Homo sapiens (Human) - DENND1B gene Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). Indicus|evm.model.CM009506.1.709 Q5VUE5 CA053_HUMAN 90.909 0.4 0.551724 C1orf53 - Uncharacterized protein C1orf53 - Homo sapiens (Human) - C1orf53 gene Indicus|evm.model.CM009506.1.710 A0JNI8 LHX9_BOVIN 100.000 0.994975 1.00252 LHX9 - LIM/homeobox protein Lhx9 - Bos taurus (Bovine) - LHX9 gene Involved in gonadal development. Indicus|evm.model.CM009506.1.712 Q8TDX7 NEK7_HUMAN 87.086 0.992481 0.880795 NEK7 - Serine/threonine-protein kinase Nek7 - Homo sapiens (Human) - NEK7 gene Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596). Phosphorylates RPS6KB1 (By similarity). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). Indicus|evm.model.CM009506.1.713 Q96LB4 VATG3_HUMAN 79.487 0.97479 1.00847 ATP6V1G3 - V-type proton ATPase subunit G 3 - Homo sapiens (Human) - ATP6V1G3 gene Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Indicus|evm.model.CM009506.1.714 P08575 PTPRC_HUMAN 80.000 0.0253275 0.876723 PTPRC - Receptor-type tyrosine-protein phosphatase C precursor - Homo sapiens (Human) - PTPRC gene Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Indicus|evm.model.CM009506.1.717 Q5RCP8 H2B2E_PONAB 89.744 0.361905 0.833333 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009506.1.722 O00482 NR5A2_HUMAN 91.961 0.994118 0.942699 NR5A2 - Nuclear receptor subfamily 5 group A member 2 - Homo sapiens (Human) - NR5A2 gene Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity). Indicus|evm.model.CM009506.1.726 Q9Y2X9 ZN281_HUMAN 94.956 0.995624 0.510615 ZNF281 - Zinc finger protein 281 - Homo sapiens (Human) - ZNF281 gene Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. Indicus|evm.model.CM009506.1.728 Q5T1V6 DDX59_HUMAN 75.532 0.303668 2.99515 DDX59 - Probable ATP-dependent RNA helicase DDX59 - Homo sapiens (Human) - DDX59 gene RNA binding, RNA helicase activity Indicus|evm.model.CM009506.1.729 Q08AD1 CAMP2_HUMAN 75.789 0.981818 0.960376 CAMSAP2 - Calmodulin-regulated spectrin-associated protein 2 - Homo sapiens (Human) - CAMSAP2 gene Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). Indicus|evm.model.CM009506.1.730 P0C5I1 GPR25_MOUSE 72.059 0.378531 0.494413 Gpr25 - Probable G-protein coupled receptor 25 - Mus musculus (Mouse) - Gpr25 gene Orphan receptor. Indicus|evm.model.CM009506.1.732 Q7TN12 INAVA_MOUSE 80.460 0.888601 0.582202 Inava - Innate immunity activator protein - Mus musculus (Mouse) - Inava gene Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (By similarity). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). Indicus|evm.model.CM009506.1.734 O75037 KI21B_HUMAN 89.068 0.965732 0.19609 KIF21B - Kinesin-like protein KIF21B - Homo sapiens (Human) - KIF21B gene Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. Indicus|evm.model.CM009506.1.735 O75037 KI21B_HUMAN 80.985 0.936364 0.604765 KIF21B - Kinesin-like protein KIF21B - Homo sapiens (Human) - KIF21B gene Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. Indicus|evm.model.CM009506.1.736 Q08AD1 CAMP2_HUMAN 87.640 0.556962 0.106111 CAMSAP2 - Calmodulin-regulated spectrin-associated protein 2 - Homo sapiens (Human) - CAMSAP2 gene Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). Indicus|evm.model.CM009506.1.737 Q13698 CAC1S_HUMAN 83.333 0.998321 0.954084 CACNA1S - Voltage-dependent L-type calcium channel subunit alpha-1S - Homo sapiens (Human) - CACNA1S gene Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. Indicus|evm.model.CM009506.1.738 Q6XD76 ASCL4_HUMAN 85.714 0.342541 1.05233 ASCL4 - Achaete-scute homolog 4 - Homo sapiens (Human) - ASCL4 gene Could be a transcriptional regulator involved in skin development. Indicus|evm.model.CM009506.1.739 Q9P0T7 TMEM9_HUMAN 93.846 0.561947 1.23497 TMEM9 - Proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor - Homo sapiens (Human) - TMEM9 gene Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (PubMed:30374053). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (PubMed:30374053). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic regeneration (PubMed:32380568). Indicus|evm.model.CM009506.1.740 Q9CR23 TMEM9_MOUSE 94.444 0.313609 0.923497 Tmem9 - Proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor - Mus musculus (Mouse) - Tmem9 gene Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (By similarity). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (By similarity). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic regeneration (PubMed:32380568). Indicus|evm.model.CM009506.1.741 Q3KNY0 IGFN1_MOUSE 81.176 0.146853 0.200772 Igfn1 - Immunoglobulin-like and fibronectin type III domain-containing protein 1 - Mus musculus (Mouse) - Igfn1 gene nucleus, synapse, Z disc, homophilic cell adhesion via plasma membrane adhesion molecules, retina layer formation, synapse assembly Indicus|evm.model.CM009506.1.743 Q86VF2 IGFN1_HUMAN 73.580 0.860068 0.702638 IGFN1 - Immunoglobulin-like and fibronectin type III domain-containing protein 1 - Homo sapiens (Human) - IGFN1 gene nucleus, synapse, Z disc, homophilic cell adhesion via plasma membrane adhesion molecules, retina layer formation, synapse assembly Indicus|evm.model.CM009506.1.745 Q28161 PKP1_BOVIN 80.082 0.996885 0.883081 PKP1 - Plakophilin-1 - Bos taurus (Bovine) - PKP1 gene Seems to play a role in junctional plaques. Indicus|evm.model.CM009507.1.4 O95221 OR5F1_HUMAN 81.188 0.99 0.318471 OR5F1 - Olfactory receptor 5F1 - Homo sapiens (Human) - OR5F1 gene Odorant receptor. Indicus|evm.model.CM009507.1.5 Q5RCG1 TM192_PONAB 83.650 0.984962 0.98155 TMEM192 - Transmembrane protein 192 - Pongo abelii (Sumatran orangutan) - TMEM192 gene Indicus|evm.model.CM009507.1.6 P05386 RLA1_HUMAN 57.018 0.978723 0.824561 RPLP1 - 60S acidic ribosomal protein P1 - Homo sapiens (Human) - RPLP1 gene Plays an important role in the elongation step of protein synthesis. Indicus|evm.model.CM009507.1.7 O95198 KLHL2_HUMAN 98.651 0.996633 1.00169 KLHL2 - Kelch-like protein 2 - Homo sapiens (Human) - KLHL2 gene Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. Indicus|evm.model.CM009507.1.8 Q5R574 MSMO1_PONAB 95.222 0.993197 1.00341 MSMO1 - Methylsterol monooxygenase 1 - Pongo abelii (Sumatran orangutan) - MSMO1 gene Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol. Indicus|evm.model.CM009507.1.9 P04836 CBPE_BOVIN 100.000 0.995798 1.00211 CPE - Carboxypeptidase E precursor - Bos taurus (Bovine) - CPE gene Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. Indicus|evm.model.CM009507.1.10 Q9HBF4 ZFYV1_HUMAN 81.301 0.80292 0.528958 ZFYVE1 - Zinc finger FYVE domain-containing protein 1 - Homo sapiens (Human) - ZFYVE1 gene Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955). Indicus|evm.model.CM009507.1.11 Q5RFL4 ZFYV1_PONAB 64.516 0.931148 0.386565 ZFYVE1 - Zinc finger FYVE domain-containing protein 1 - Pongo abelii (Sumatran orangutan) - ZFYVE1 gene Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). Regulates the morphology, size and distribution of LDs (By similarity). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contact sites by forming a complex with RAB18 and ZW10 (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (By similarity). Indicus|evm.model.CM009507.1.12 O43897 TLL1_HUMAN 66.667 0.411765 0.134255 TLL1 - Tolloid-like protein 1 precursor - Homo sapiens (Human) - TLL1 gene Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Indicus|evm.model.CM009507.1.13 O43897 TLL1_HUMAN 91.554 0.957274 0.970385 TLL1 - Tolloid-like protein 1 precursor - Homo sapiens (Human) - TLL1 gene Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Indicus|evm.model.CM009507.1.14 Q49MG5 MAP9_HUMAN 72.138 0.991247 0.706337 MAP9 - Microtubule-associated protein 9 - Homo sapiens (Human) - MAP9 gene Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules. Indicus|evm.model.CM009507.1.17 P79113 NPY2R_BOVIN 99.738 0.994778 0.997396 NPY2R - Neuropeptide Y receptor type 2 - Bos taurus (Bovine) - NPY2R gene Receptor for neuropeptide Y and peptide YY. Indicus|evm.model.CM009507.1.18 Q8TBY0 RBM46_HUMAN 97.863 0.960905 0.91182 RBM46 - Probable RNA-binding protein 46 - Homo sapiens (Human) - RBM46 gene nucleus, mRNA binding, RNA binding Indicus|evm.model.CM009507.1.20 Q9BGL2 LRAT_BOVIN 97.826 0.789655 1.26087 LRAT - Lecithin retinol acyltransferase - Bos taurus (Bovine) - LRAT gene Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938, PubMed:2722792). Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity). Indicus|evm.model.CM009507.1.21 P12799 FIBG_BOVIN 98.161 0.990826 0.981982 FGG - Fibrinogen gamma-B chain precursor - Bos taurus (Bovine) - FGG gene Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. Indicus|evm.model.CM009507.1.22 P02672 FIBA_BOVIN 98.366 0.729117 1.3626 FGA - Fibrinogen alpha chain precursor - Bos taurus (Bovine) - FGA gene Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. Indicus|evm.model.CM009507.1.23 P02676 FIBB_BOVIN 99.359 0.941532 1.05983 FGB - Fibrinogen beta chain precursor - Bos taurus (Bovine) - FGB gene Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. Indicus|evm.model.CM009507.1.24 Q2KID6 PLRG1_BOVIN 100.000 0.996109 1.00195 PLRG1 - Pleiotropic regulator 1 - Bos taurus (Bovine) - PLRG1 gene Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Indicus|evm.model.CM009507.1.25 Q6V1P9 PCD23_HUMAN 80.707 0.886667 0.222486 DCHS2 - Protocadherin-23 - Homo sapiens (Human) - DCHS2 gene Calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009507.1.26 Q6V1P9 PCD23_HUMAN 77.629 0.989334 0.806586 DCHS2 - Protocadherin-23 - Homo sapiens (Human) - DCHS2 gene Calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009507.1.29 Q863H1 SFRP2_CANLF 96.939 0.99322 1.0034 SFRP2 - Secreted frizzled-related protein 2 precursor - Canis lupus familiaris (Dog) - SFRP2 gene Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. Indicus|evm.model.CM009507.1.30 Q8N4F7 RN175_HUMAN 93.060 0.975309 0.987805 RNF175 - RING finger protein 175 - Homo sapiens (Human) - RNF175 gene endoplasmic reticulum membrane, Golgi membrane, ubiquitin protein ligase activity, endoplasmic reticulum unfolded protein response, ubiquitin-dependent ERAD pathway Indicus|evm.model.CM009507.1.31 B5T267 TLR2_BOSIN 99.745 0.997452 1.00128 TLR2 - Toll-like receptor 2 precursor - Bos indicus (Zebu) - TLR2 gene Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity). Indicus|evm.model.CM009507.1.33 Q08DV9 T131L_BOVIN 97.254 0.998723 0.979975 TMEM131L - Transmembrane protein 131-like precursor - Bos taurus (Bovine) - TMEM131L gene membrane, plasma membrane, negative regulation of canonical Wnt signaling pathway Indicus|evm.model.CM009507.1.34 Q32L19 MND1_BOVIN 99.512 0.990291 1.00488 MND1 - Meiotic nuclear division protein 1 homolog - Bos taurus (Bovine) - MND1 gene Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (By similarity). Indicus|evm.model.CM009507.1.35 A4IF63 TRIM2_BOVIN 100.000 0.962435 1.03763 TRIM2 - Tripartite motif-containing protein 2 - Bos taurus (Bovine) - TRIM2 gene E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Indicus|evm.model.CM009507.1.37 Q9C0D6 FHDC1_HUMAN 72.370 0.750719 0.912511 FHDC1 - FH2 domain-containing protein 1 - Homo sapiens (Human) - FHDC1 gene Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). Indicus|evm.model.CM009507.1.38 P53367 ARFP1_HUMAN 89.276 0.926431 0.983914 ARFIP1 - Arfaptin-1 - Homo sapiens (Human) - ARFIP1 gene Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. Indicus|evm.model.CM009507.1.39 Q8IY51 TIGD4_HUMAN 90.234 0.996101 1.00195 TIGD4 - Tigger transposable element-derived protein 4 - Homo sapiens (Human) - TIGD4 gene nucleus, DNA binding Indicus|evm.model.CM009507.1.40 Q6P9G4 TM154_HUMAN 64.362 0.953125 1.04918 TMEM154 - Transmembrane protein 154 precursor - Homo sapiens (Human) - TMEM154 gene Indicus|evm.model.CM009507.1.42 F1MNN4 FBXW7_BOVIN 100.000 0.96049 1.03966 FBXW7 - F-box/WD repeat-containing protein 7 - Bos taurus (Bovine) - FBXW7 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (By similarity). Indicus|evm.model.CM009507.1.45 O75879 GATB_HUMAN 85.507 0.994585 0.994614 GATB - Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial precursor - Homo sapiens (Human) - GATB gene Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Indicus|evm.model.CM009507.1.46 Q05DH4 F16A1_HUMAN 82.421 0.997118 1.00096 FHIP1A - FHF complex subunit HOOK interacting protein 1A - Homo sapiens (Human) - FHIP1A gene Probable component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Indicus|evm.model.CM009507.1.47 Q7RTY5 PRS48_HUMAN 57.736 0.926199 0.82622 PRSS48 - Serine protease 48 precursor - Homo sapiens (Human) - PRSS48 gene extracellular space, serine-type endopeptidase activity, proteolysis Indicus|evm.model.CM009507.1.49 Q5HYK7 SH319_HUMAN 80.784 0.732276 1.35696 SH3D19 - SH3 domain-containing protein 19 - Homo sapiens (Human) - SH3D19 gene May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. Indicus|evm.model.CM009507.1.50 P61247 RS3A_HUMAN 100.000 0.992453 1.00379 RPS3A - 40S ribosomal protein S3a - Homo sapiens (Human) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009507.1.51 P50851 LRBA_HUMAN 83.882 0.998048 0.715683 LRBA - Lipopolysaccharide-responsive and beige-like anchor protein - Homo sapiens (Human) - LRBA gene May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. Indicus|evm.model.CM009507.1.52 Q8BPP1 MB212_MOUSE 100.000 0.994444 1.00279 Mab21l2 - Protein mab-21-like 2 - Mus musculus (Mouse) - Mab21l2 gene Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning. Indicus|evm.model.CM009507.1.54 D2I3C6 DCLK2_AILME 96.893 0.957938 0.940051 DCLK2 - Serine/threonine-protein kinase DCLK2 - Ailuropoda melanoleuca (Giant panda) - DCLK2 gene Protein kinase with a significantly reduced Ca(2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). Indicus|evm.model.CM009507.1.55 A0A1B0GVH7 IQCM_HUMAN 67.556 0.991753 0.968064 IQCM - IQ domain-containing protein M - Homo sapiens (Human) - IQCM gene Indicus|evm.model.CM009507.1.56 O15439 MRP4_HUMAN 69.022 0.740891 0.186415 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009507.1.58 O15439 MRP4_HUMAN 86.585 0.987805 0.0618868 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009507.1.60 P08235 MCR_HUMAN 95.729 0.994962 0.403455 NR3C2 - Mineralocorticoid receptor - Homo sapiens (Human) - NR3C2 gene Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. Indicus|evm.model.CM009507.1.61 Q08DP6 RHG10_BOVIN 99.213 0.942999 1.02803 ARHGAP10 - Rho GTPase-activating protein 10 - Bos taurus (Bovine) - ARHGAP10 gene GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Indicus|evm.model.CM009507.1.62 Q6P2P2 ANM9_HUMAN 91.135 0.997639 1.00237 PRMT9 - Protein arginine N-methyltransferase 9 - Homo sapiens (Human) - PRMT9 gene Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344). Indicus|evm.model.CM009507.1.63 Q17QL9 T184C_BOVIN 99.772 0.927813 1.07534 TMEM184C - Transmembrane protein 184C - Bos taurus (Bovine) - TMEM184C gene Possible tumor suppressor which may play a role in cell growth. Indicus|evm.model.CM009507.1.64 P21450 EDNRA_BOVIN 100.000 0.995327 1.00234 EDNRA - Endothelin-1 receptor precursor - Bos taurus (Bovine) - EDNRA gene Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Indicus|evm.model.CM009507.1.65 Q4R6M4 TTC29_MACFA 83.721 0.912959 1.08842 TTC29 - Tetratricopeptide repeat protein 29 - Macaca fascicularis (Crab-eating macaque) - TTC29 gene Axonemal protein which is implicated in axonemal and/or peri-axonemal structures assembly and regulates flagella assembly and beating and therefore sperm motility. Indicus|evm.model.CM009507.1.66 E1B7X3 R146A_BOVIN 98.844 0.994236 1.00289 RNF146A - E3 ubiquitin-protein ligase RNF146-A - Bos taurus (Bovine) - RNF146A gene E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity). Indicus|evm.model.CM009507.1.67 Q63934 PO4F2_MOUSE 98.054 0.99511 0.995134 Pou4f2 - POU domain, class 4, transcription factor 2 - Mus musculus (Mouse) - Pou4f2 gene Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:7904822, PubMed:8995448, PubMed:8972215, PubMed:10357904, PubMed:10414983, PubMed:11163266, PubMed:17668438, PubMed:25775587). Functions either as activator or repressor by modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:7904822, PubMed:7935408, PubMed:8065921, PubMed:7852360, PubMed:7797498, PubMed:8662774, PubMed:9694219, PubMed:10526314, PubMed:15733064, PubMed:17145718, PubMed:18368538). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes (PubMed:7904822, PubMed:8290353, PubMed:9111308, PubMed:10414983, PubMed:16152597, PubMed:17668438, PubMed:24643061). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed:8632990, PubMed:10357904, PubMed:25775587). Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding (PubMed:8995448, PubMed:9261145, PubMed:8972215, PubMed:10357904, PubMed:11163266, PubMed:24643061, PubMed:25775587). Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification (PubMed:21875655). In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis (PubMed:17145718). Negatively regulates BAX promoter activity in the absence of TP53 (PubMed:17145718). Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter (PubMed:9448000). Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif (PubMed:7935408, PubMed:8065921, PubMed:8537352, PubMed:7852360, PubMed:8662774). Involved in TNFSF11-mediated terminal osteoclast differentiation (PubMed:17668438). Indicus|evm.model.CM009507.1.68 Q0GE19 NTCP7_HUMAN 94.118 0.994135 1.00294 SLC10A7 - Sodium/bile acid cotransporter 7 - Homo sapiens (Human) - SLC10A7 gene Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization (PubMed:30082715, PubMed:29878199). Also involved in the regulation of cellular calcium homeostasis (PubMed:30082715, PubMed:31191616). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate). Indicus|evm.model.CM009507.1.70 A0A1B0GV85 RELD1_HUMAN 66.294 0.996269 1.01901 REELD1 - Reelin domain-containing protein 1 precursor - Homo sapiens (Human) - REELD1 gene Indicus|evm.model.CM009507.1.71 P62313 LSM6_MOUSE 100.000 0.612613 1.3875 Lsm6 - U6 snRNA-associated Sm-like protein LSm6 - Mus musculus (Mouse) - Lsm6 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Indicus|evm.model.CM009507.1.72 Q17R98 ZN827_HUMAN 94.271 0.673709 0.788159 ZNF827 - Zinc finger protein 827 - Homo sapiens (Human) - ZNF827 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009507.1.73 C9J302 CD051_HUMAN 58.621 0.920904 0.876238 C4orf51 - Uncharacterized protein C4orf51 - Homo sapiens (Human) - C4orf51 gene Indicus|evm.model.CM009507.1.74 Q8IVH4 MMAA_HUMAN 88.249 0.985782 1.00957 MMAA - Methylmalonic aciduria type A protein, mitochondrial precursor - Homo sapiens (Human) - MMAA gene GTPase, binds and hydrolyzes GTP (PubMed:28497574, PubMed:20876572, PubMed:21138732, PubMed:28943303). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (PubMed:28497574, PubMed:20876572). Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (PubMed:28497574, PubMed:20876572). Plays a dual role as both a protectase and a reactivase for MMUT (PubMed:21138732, PubMed:28943303). Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (PubMed:21138732, PubMed:28943303). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (PubMed:21138732, PubMed:28943303). Indicus|evm.model.CM009507.1.75 Q1JQA2 SMAD1_BOVIN 100.000 0.995708 1.00215 SMAD1 - Mothers against decapentaplegic homolog 1 - Bos taurus (Bovine) - SMAD1 gene Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Indicus|evm.model.CM009507.1.76 Q01804 OTUD4_HUMAN 87.431 0.998158 0.974865 OTUD4 - OTU domain-containing protein 4 - Homo sapiens (Human) - OTUD4 gene Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Indicus|evm.model.CM009507.1.77 P61222 ABCE1_MOUSE 99.833 0.996667 1.00167 Abce1 - ATP-binding cassette sub-family E member 1 - Mus musculus (Mouse) - Abce1 gene Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (By similarity). Together with PELO and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (By similarity). Together with PELO and HBS1L, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (By similarity). Plays a role in the regulation of mRNA turnover (PubMed:10866653). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (By similarity). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (By similarity). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (By similarity). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (By similarity). Indicus|evm.model.CM009507.1.78 Q9UM13 APC10_HUMAN 100.000 0.560976 1.77297 ANAPC10 - Anaphase-promoting complex subunit 10 - Homo sapiens (Human) - ANAPC10 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Indicus|evm.model.CM009507.1.80 Q96QV1 HHIP_HUMAN 93.780 0.395437 0.751429 HHIP - Hedgehog-interacting protein precursor - Homo sapiens (Human) - HHIP gene Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Indicus|evm.model.CM009507.1.82 Q5H8B9 FREM3_MOUSE 68.548 0.103806 0.544512 Frem3 - FRAS1-related extracellular matrix protein 3 precursor - Mus musculus (Mouse) - Frem3 gene Extracellular matrix protein which may play a role in cell adhesion. Indicus|evm.model.CM009507.1.83 P0C091 FREM3_HUMAN 63.362 0.931507 0.102384 FREM3 - FRAS1-related extracellular matrix protein 3 precursor - Homo sapiens (Human) - FREM3 gene Extracellular matrix protein which may play a role in cell adhesion. Indicus|evm.model.CM009507.1.85 P0C091 FREM3_HUMAN 66.841 0.882812 0.179523 FREM3 - FRAS1-related extracellular matrix protein 3 precursor - Homo sapiens (Human) - FREM3 gene Extracellular matrix protein which may play a role in cell adhesion. Indicus|evm.model.CM009507.1.86 O60264 SMCA5_HUMAN 98.194 0.998101 1.00095 SMARCA5 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 - Homo sapiens (Human) - SMARCA5 gene Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. Indicus|evm.model.CM009507.1.87 A6QLU3 GAB1_BOVIN 99.712 0.997122 1.00144 GAB1 - GRB2-associated-binding protein 1 - Bos taurus (Bovine) - GAB1 gene Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. Indicus|evm.model.CM009507.1.88 Q8NB14 UBP38_HUMAN 92.706 0.998079 0.99904 USP38 - Ubiquitin carboxyl-terminal hydrolase 38 - Homo sapiens (Human) - USP38 gene Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked ubiquitin chains. Indicus|evm.model.CM009507.1.91 Q4R4D7 INP4B_MACFA 93.665 0.237581 1.13899 INPP4B - Type II inositol 3,4-bisphosphate 4-phosphatase - Macaca fascicularis (Crab-eating macaque) - INPP4B gene Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (By similarity). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). Indicus|evm.model.CM009507.1.92 Q28028 IL15_BOVIN 100.000 0.892086 0.858025 IL15 - Interleukin-15 precursor - Bos taurus (Bovine) - IL15 gene Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity). Indicus|evm.model.CM009507.1.94 Q32LC9 ZN330_BOVIN 100.000 0.74186 1.34375 ZNF330 - Zinc finger protein 330 - Bos taurus (Bovine) - ZNF330 gene nucleus Indicus|evm.model.CM009507.1.96 Q9ULK6 RN150_HUMAN 96.283 0.992593 0.616438 RNF150 - RING finger protein 150 precursor - Homo sapiens (Human) - RNF150 gene cytoplasm, ubiquitin protein ligase activity, ubiquitin-dependent protein catabolic process Indicus|evm.model.CM009507.1.97 Q6ZT07 TBCD9_HUMAN 93.716 0.998396 0.984992 TBC1D9 - TBC1 domain family member 9 - Homo sapiens (Human) - TBC1D9 gene May act as a GTPase-activating protein for Rab family protein(s). Indicus|evm.model.CM009507.1.98 W5PSH7 UCP1_SHEEP 98.361 0.993464 1.00328 UCP1 - Mitochondrial brown fat uncoupling protein 1 - Ovis aries (Sheep) - UCP1 gene Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:26038550). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity). Indicus|evm.model.CM009507.1.99 Q08DZ3 ELMD2_BOVIN 100.000 0.993197 1.00341 ELMOD2 - ELMO domain-containing protein 2 - Bos taurus (Bovine) - ELMOD2 gene Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Indicus|evm.model.CM009507.1.100 A6NG13 MGT4D_HUMAN 70.588 0.989362 1.00535 MGAT4D - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D - Homo sapiens (Human) - MGAT4D gene May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis. Indicus|evm.model.CM009507.1.102 Q3SYT6 CLGN_BOVIN 99.505 0.9967 1 CLGN - Calmegin precursor - Bos taurus (Bovine) - CLGN gene Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). Indicus|evm.model.CM009507.1.103 Q5XJK1 SCOCB_DANRE 93.506 0.475 2.10526 scocb - Short coiled-coil protein B - Danio rerio (Zebrafish) - scocb gene Positive regulator of amino acid starvation-induced autophagy. Indicus|evm.model.CM009507.1.104 Q96JK9 MAML3_HUMAN 95.946 0.777778 0.166081 MAML3 - Mastermind-like protein 3 - Homo sapiens (Human) - MAML3 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Indicus|evm.model.CM009507.1.106 Q96JK9 MAML3_HUMAN 87.817 0.99791 0.840949 MAML3 - Mastermind-like protein 3 - Homo sapiens (Human) - MAML3 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Indicus|evm.model.CM009507.1.107 Q2KJG4 MGST2_BOVIN 81.507 0.983471 0.828767 MGST2 - Microsomal glutathione S-transferase 2 - Bos taurus (Bovine) - MGST2 gene Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells. Indicus|evm.model.CM009507.1.108 Q8WTS6 SETD7_HUMAN 98.361 0.892421 1.11749 SETD7 - Histone-lysine N-methyltransferase SETD7 - Homo sapiens (Human) - SETD7 gene Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Indicus|evm.model.CM009507.1.109 Q5R615 RB33B_PONAB 96.943 0.991304 1.00437 RAB33B - Ras-related protein Rab-33B - Pongo abelii (Sumatran orangutan) - RAB33B gene Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation (By similarity). Indicus|evm.model.CM009507.1.110 Q9BXJ9 NAA15_HUMAN 99.192 0.997693 1.00115 NAA15 - N-alpha-acetyltransferase 15, NatA auxiliary subunit - Homo sapiens (Human) - NAA15 gene Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. Indicus|evm.model.CM009507.1.111 Q02376 NDUC1_BOVIN 100.000 0.974026 1.01316 NDUFC1 - NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor - Bos taurus (Bovine) - NDUFC1 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009507.1.112 A6QLZ1 HUMMR_BOVIN 97.917 0.991701 1.00417 MGARP - Protein MGARP - Bos taurus (Bovine) - MGARP gene Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). Indicus|evm.model.CM009507.1.113 Q15723 ELF2_HUMAN 97.138 0.996639 1.00337 ELF2 - ETS-related transcription factor Elf-2 - Homo sapiens (Human) - ELF2 gene Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter. Indicus|evm.model.CM009507.1.114 Q9UK39 NOCT_HUMAN 95.055 0.914358 0.921114 NOCT - Nocturnin precursor - Homo sapiens (Human) - NOCT gene Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). Indicus|evm.model.CM009507.1.115 P43244 MATR3_RAT 90.586 0.631016 0.885207 Matr3 - Matrin-3 - Rattus norvegicus (Rat) - Matr3 gene May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins (By similarity). Indicus|evm.model.CM009507.1.116 Q9UPY5 XCT_HUMAN 78.088 0.986607 0.894212 SLC7A11 - Cystine/glutamate transporter - Homo sapiens (Human) - SLC7A11 gene Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Indicus|evm.model.CM009507.1.119 A7MB46 PCD18_BOVIN 99.912 0.998238 1.00088 PCDH18 - Protocadherin-18 precursor - Bos taurus (Bovine) - PCDH18 gene Potential calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009507.1.120 P21741 MK_HUMAN 92.969 0.579909 1.53147 MDK - Midkine precursor - Homo sapiens (Human) - MDK gene Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:18469519, PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:24458438, PubMed:15466886, PubMed:12084985, PubMed:10772929). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:12084985, PubMed:10212223). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:10683378, PubMed:24458438, PubMed:22323540, PubMed:12084985, PubMed:15466886, PubMed:10772929). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity). Indicus|evm.model.CM009507.1.122 Q9HD36 B2L10_HUMAN 52.577 0.989189 0.906863 BCL2L10 - Bcl-2-like protein 10 - Homo sapiens (Human) - BCL2L10 gene Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11689480, PubMed:11278245). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). Indicus|evm.model.CM009507.1.123 A5JSS2 RL21_CAPHI 48.214 0.916667 0.375 RPL21 - 60S ribosomal protein L21 - Capra hircus (Goat) - RPL21 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009507.1.124 P0CB38 PAB4L_HUMAN 89.702 0.991914 1.0027 PABPC4L - Polyadenylate-binding protein 4-like - Homo sapiens (Human) - PABPC4L gene May bind RNA. Indicus|evm.model.CM009507.1.125 Q9XSJ4 ENOA_BOVIN 52.432 0.986111 0.331797 ENO1 - Alpha-enolase - Bos taurus (Bovine) - ENO1 gene Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:7499243). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). Indicus|evm.model.CM009507.1.126 P0CW01 TSPYA_HUMAN 54.104 0.812308 1.05519 TSPY10 - Testis-specific Y-encoded protein 10 - Homo sapiens (Human) - TSPY10 gene chromatin, nucleus, chromatin binding, histone binding Indicus|evm.model.CM009507.1.127 O19110 TSPY1_BOVIN 71.025 0.737968 1.17981 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.128 P78395 PRAME_HUMAN 62.035 0.984375 1.00589 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009507.1.129 Q9P2E7 PCD10_HUMAN 98.549 0.974504 1.01827 PCDH10 - Protocadherin-10 precursor - Homo sapiens (Human) - PCDH10 gene Potential calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009507.1.130 Q3ZCH0 GRP75_BOVIN 70.940 0.956522 0.135493 HSPA9 - Stress-70 protein, mitochondrial precursor - Bos taurus (Bovine) - HSPA9 gene Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis probably via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Indicus|evm.model.CM009507.1.131 Q6Q311 RS25_SHEEP 82.759 0.809524 0.84 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Indicus|evm.model.CM009507.1.132 Q5R8R1 ARP3_PONAB 92.481 0.910345 0.34689 ACTR3 - Actin-related protein 3 - Pongo abelii (Sumatran orangutan) - ACTR3 gene ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis. Indicus|evm.model.CM009507.1.133 Q4V7C7 ARP3_RAT 96.939 0.906542 0.255981 Actr3 - Actin-related protein 3 - Rattus norvegicus (Rat) - Actr3 gene ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis. Indicus|evm.model.CM009507.1.135 Q8N1A6 CD033_HUMAN 88.095 0.988166 0.849246 C4orf33 - UPF0462 protein C4orf33 - Homo sapiens (Human) - C4orf33 gene Indicus|evm.model.CM009507.1.136 Q96NL6 SCLT1_HUMAN 82.438 0.997101 1.00291 SCLT1 - Sodium channel and clathrin linker 1 - Homo sapiens (Human) - SCLT1 gene Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity). Indicus|evm.model.CM009507.1.137 Q5E9T7 JADE1_BOVIN 99.209 0.598341 1.65815 JADE1 - Protein Jade-1 - Bos taurus (Bovine) - JADE1 gene Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function. Indicus|evm.model.CM009507.1.138 Q5RFF4 EIF1_PONAB 88.793 0.982906 1.0354 EIF1 - Eukaryotic translation initiation factor 1 - Pongo abelii (Sumatran orangutan) - EIF1 gene Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (By similarity). Indicus|evm.model.CM009507.1.139 Q2KIY0 COMD6_BOVIN 100.000 0.976744 1.01176 COMMD6 - COMM domain-containing protein 6 - Bos taurus (Bovine) - COMMD6 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Inhibits TNF-induced NFKB1 activation. Indicus|evm.model.CM009507.1.140 O15173 PGRC2_HUMAN 72.646 0.988372 0.7713 PGRMC2 - Membrane-associated progesterone receptor component 2 - Homo sapiens (Human) - PGRMC2 gene Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). Indicus|evm.model.CM009507.1.141 Q8BFQ4 WDR82_MOUSE 49.171 0.95082 0.389776 Wdr82 - WD repeat-containing protein 82 - Mus musculus (Mouse) - Wdr82 gene Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Possible role in telomere length maintenance and in mRNA processing (By similarity). Indicus|evm.model.CM009507.1.142 Q58DA7 GLRX3_BOVIN 72.294 0.984375 0.57485 GLRX3 - Glutaredoxin-3 - Bos taurus (Bovine) - GLRX3 gene Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). Indicus|evm.model.CM009507.1.143 Q659C4 LAR1B_HUMAN 89.192 0.808969 1.21991 LARP1B - La-related protein 1B - Homo sapiens (Human) - LARP1B gene nucleus, RNA binding Indicus|evm.model.CM009507.1.144 O46414 FRIH_BOVIN 86.806 0.986207 0.801105 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009507.1.145 Q4V7A8 ABD18_RAT 90.086 0.995614 0.982759 Abhd18 - Protein ABHD18 precursor - Rattus norvegicus (Rat) - Abhd18 gene Indicus|evm.model.CM009507.1.146 Q8NHS3 MFSD8_HUMAN 87.476 0.996154 1.00386 MFSD8 - Major facilitator superfamily domain-containing protein 8 - Homo sapiens (Human) - MFSD8 gene May be a carrier that transport small solutes by using chemiosmotic ion gradients. Indicus|evm.model.CM009507.1.147 A2VDZ4 PLK4_BOVIN 99.888 0.997763 1.00112 PLK4 - Serine/threonine-protein kinase PLK4 - Bos taurus (Bovine) - PLK4 gene Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity). Phosphorylates CEP131 and PCM1 which is essential for proper organization and integrity of centriolar satellites (By similarity). Indicus|evm.model.CM009507.1.148 O95757 HS74L_HUMAN 94.881 0.819336 1.2205 HSPA4L - Heat shock 70 kDa protein 4L - Homo sapiens (Human) - HSPA4L gene Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. Indicus|evm.model.CM009507.1.149 Q2YDD9 ADT4_BOVIN 99.381 0.993827 1.0031 SLC25A31 - ADP/ATP translocase 4 - Bos taurus (Bovine) - SLC25A31 gene ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes. Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it (By similarity). Indicus|evm.model.CM009507.1.150 F1MDL2 INTU_BOVIN 99.357 0.997859 1.00107 INTU - Protein inturned - Bos taurus (Bovine) - INTU gene Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). Indicus|evm.model.CM009507.1.151 Q6V0I7 FAT4_HUMAN 95.505 0.999599 1.0004 FAT4 - Protocadherin Fat 4 precursor - Homo sapiens (Human) - FAT4 gene Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). Indicus|evm.model.CM009507.1.155 A5D992 SPY1_BOVIN 100.000 0.99375 1.00313 SPRY1 - Protein sprouty homolog 1 - Bos taurus (Bovine) - SPRY1 gene Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Indicus|evm.model.CM009507.1.156 Q8NB90 AFG2H_HUMAN 85.682 0.997745 0.993281 SPATA5 - ATPase family protein 2 homolog - Homo sapiens (Human) - SPATA5 gene ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes. May be involved in morphological and functional mitochondrial transformations during spermatogenesis. Indicus|evm.model.CM009507.1.157 P53370 NUDT6_HUMAN 81.529 0.987382 1.00316 NUDT6 - Nucleoside diphosphate-linked moiety X motif 6 - Homo sapiens (Human) - NUDT6 gene May contribute to the regulation of cell proliferation. Indicus|evm.model.CM009507.1.159 Q5RC62 BBS12_PONAB 74.298 0.997179 0.998592 BBS12 - Bardet-Biedl syndrome 12 protein homolog - Pongo abelii (Sumatran orangutan) - BBS12 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation. Indicus|evm.model.CM009507.1.160 Q8K4K1 CETN4_MOUSE 85.119 0.988024 0.994048 Cetn4 - Centrin-4 - Mus musculus (Mouse) - Cetn4 gene Ca(2+)-binding protein that may be involved in basal body assembly or in a subsequent step of ciliogenesis. Indicus|evm.model.CM009507.1.161 Q76LU5 IL21_BOVIN 99.315 0.986395 0.967105 IL21 - Interleukin-21 precursor - Bos taurus (Bovine) - IL21 gene Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity). Indicus|evm.model.CM009507.1.162 P05016 IL2_BOVIN 100.000 0.987179 1.00645 IL2 - Interleukin-2 precursor - Bos taurus (Bovine) - IL2 gene Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. Indicus|evm.model.CM009507.1.163 A3KMV5 UBA1_BOVIN 71.207 0.997579 0.780718 UBA1 - Ubiquitin-like modifier-activating enzyme 1 - Bos taurus (Bovine) - UBA1 gene Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. Indicus|evm.model.CM009507.1.165 P78395 PRAME_HUMAN 66.324 0.985772 0.966601 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009507.1.167 P78395 PRAME_HUMAN 63.673 0.651832 1.50098 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009507.1.168 P78395 PRAME_HUMAN 54.209 0.882736 0.603143 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009507.1.169 O19110 TSPY1_BOVIN 79.365 0.816901 0.223975 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.170 Q5SUE7 ADAD1_MOUSE 91.319 0.99481 0.933764 Adad1 - Adenosine deaminase domain-containing protein 1 - Mus musculus (Mouse) - Adad1 gene Plays a role in spermatogenesis. Binds to RNA but not to DNA. Indicus|evm.model.CM009507.1.171 Q2LD37 K1109_HUMAN 97.469 0.593589 1.00979 KIAA1109 - Transmembrane protein KIAA1109 - Homo sapiens (Human) - KIAA1109 gene Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as regulator of phagocytosis (PubMed:31540829). Indicus|evm.model.CM009507.1.172 A5D787 M17L2_BOVIN 94.000 0.980198 0.463303 MPV17L2 - Mpv17-like protein 2 - Bos taurus (Bovine) - MPV17L2 gene Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity). Indicus|evm.model.CM009507.1.173 Q13507 TRPC3_HUMAN 98.565 0.906623 1.10167 TRPC3 - Short transient receptor potential channel 3 - Homo sapiens (Human) - TRPC3 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. Indicus|evm.model.CM009507.1.174 P15927 RFA2_HUMAN 85.577 0.980952 0.388889 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Indicus|evm.model.CM009507.1.177 Q8N475 FSTL5_HUMAN 94.247 0.994536 0.432113 FSTL5 - Follistatin-related protein 5 precursor - Homo sapiens (Human) - FSTL5 gene cell differentiation, multicellular organism development Indicus|evm.model.CM009507.1.178 P18576 NFYA_RAT 83.036 0.982301 0.331378 Nfya - Nuclear transcription factor Y subunit alpha - Rattus norvegicus (Rat) - Nfya gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. Indicus|evm.model.CM009507.1.179 Q5E9S2 NFYA_BOVIN 81.081 0.786765 0.398827 NFYA - Nuclear transcription factor Y subunit alpha - Bos taurus (Bovine) - NFYA gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1 (By similarity). Indicus|evm.model.CM009507.1.180 Q17QJ0 ASF1B_BOVIN 54.491 0.983193 0.589109 ASF1B - Histone chaperone ASF1B - Bos taurus (Bovine) - ASF1B gene Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (By similarity). Indicus|evm.model.CM009507.1.182 A5A6H4 ROA1_PANTR 81.884 0.68 0.625 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Indicus|evm.model.CM009507.1.185 Q96KP6 TNIP3_HUMAN 73.856 0.846591 1.08308 TNIP3 - TNFAIP3-interacting protein 3 - Homo sapiens (Human) - TNIP3 gene Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. Indicus|evm.model.CM009507.1.186 Q9P278 FNIP2_HUMAN 70.874 0.950495 0.997307 FNIP2 - Folliculin-interacting protein 2 - Homo sapiens (Human) - FNIP2 gene Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:18663353, PubMed:31672913). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:18403135). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:18403135). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:18403135). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). Indicus|evm.model.CM009507.1.187 P26882 PPID_BOVIN 99.730 0.994609 1.0027 PPID - Peptidyl-prolyl cis-trans isomerase D - Bos taurus (Bovine) - PPID gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Indicus|evm.model.CM009507.1.188 Q2KIG0 ETFD_BOVIN 99.835 0.995066 0.985413 ETFDH - Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor - Bos taurus (Bovine) - ETFDH gene Accepts electrons from ETF and reduces ubiquinone. Indicus|evm.model.CM009507.1.189 Q96IK1 BOD1_HUMAN 66.071 0.591398 0.502703 BOD1 - Biorientation of chromosomes in cell division protein 1 - Homo sapiens (Human) - BOD1 gene Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Indicus|evm.model.CM009507.1.190 Q0II83 CD046_BOVIN 100.000 0.982456 1.00885 Uncharacterized protein C4orf46 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009507.1.191 Q9HBX9 RXFP1_HUMAN 89.368 0.997131 0.92074 RXFP1 - Relaxin receptor 1 - Homo sapiens (Human) - RXFP1 gene Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. Indicus|evm.model.CM009507.1.192 Q91ZZ5 RXFP2_MOUSE 67.442 0.418367 0.132972 Rxfp2 - Relaxin receptor 2 - Mus musculus (Mouse) - Rxfp2 gene Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity). Indicus|evm.model.CM009507.1.193 A6QQU6 TM144_BOVIN 99.713 0.994269 1.00287 TMEM144 - Transmembrane protein 144 - Bos taurus (Bovine) - TMEM144 gene Indicus|evm.model.CM009507.1.194 Q6UWH4 GAK1B_HUMAN 83.815 0.996154 1.00193 GASK1B - Golgi-associated kinase 1B - Homo sapiens (Human) - GASK1B gene Golgi apparatus Indicus|evm.model.CM009507.1.195 Q5R4M0 GRIA2_PONAB 98.942 0.959368 1.0034 GRIA2 - Glutamate receptor 2 precursor - Pongo abelii (Sumatran orangutan) - GRIA2 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Indicus|evm.model.CM009507.1.196 Q9GJS9 GLRB_BOVIN 100.000 0.402299 1.22535 GLRB - Glycine receptor subunit beta precursor - Bos taurus (Bovine) - GLRB gene Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Indicus|evm.model.CM009507.1.197 Q9NRA1 PDGFC_HUMAN 93.064 0.994236 1.0058 PDGFC - Platelet-derived growth factor C precursor - Homo sapiens (Human) - PDGFC gene Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Indicus|evm.model.CM009507.1.198 P43234 CATO_HUMAN 80.471 0.933121 0.978193 CTSO - Cathepsin O precursor - Homo sapiens (Human) - CTSO gene Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. Indicus|evm.model.CM009507.1.199 Q2KIQ5 T23O_BOVIN 100.000 0.995086 1.00246 TDO2 - Tryptophan 2,3-dioxygenase - Bos taurus (Bovine) - TDO2 gene Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Indicus|evm.model.CM009507.1.200 P16068 GCYB1_BOVIN 100.000 0.996774 1.00162 GUCY1B1 - Guanylate cyclase soluble subunit beta-1 - Bos taurus (Bovine) - GUCY1B1 gene Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Indicus|evm.model.CM009507.1.201 P19687 GCYA1_BOVIN 100.000 0.99711 1.00145 GUCY1A1 - Guanylate cyclase soluble subunit alpha-1 - Bos taurus (Bovine) - GUCY1A1 gene Indicus|evm.model.CM009507.1.202 Q86T29 ZN605_HUMAN 81.899 0.898531 1.16849 ZNF605 - Zinc finger protein 605 - Homo sapiens (Human) - ZNF605 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009507.1.203 P17031 ZNF26_HUMAN 90.485 0.996124 0.968105 ZNF26 - Zinc finger protein 26 - Homo sapiens (Human) - ZNF26 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009507.1.204 P51523 ZNF84_HUMAN 89.581 0.997286 0.998645 ZNF84 - Zinc finger protein 84 - Homo sapiens (Human) - ZNF84 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009507.1.205 P52738 ZN140_HUMAN 89.760 0.978632 1.02407 ZNF140 - Zinc finger protein 140 - Homo sapiens (Human) - ZNF140 gene May be involved in transcriptional regulation as a repressor. Indicus|evm.model.CM009507.1.206 A8MT65 ZN891_HUMAN 72.894 0.996337 1.00368 ZNF891 - Zinc finger protein 891 - Homo sapiens (Human) - ZNF891 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009507.1.207 P21506 ZNF10_HUMAN 86.213 0.92233 1.07853 ZNF10 - Zinc finger protein 10 - Homo sapiens (Human) - ZNF10 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009507.1.208 Q14587 ZN268_HUMAN 81.033 0.969104 1.02534 ZNF268 - Zinc finger protein 268 - Homo sapiens (Human) - ZNF268 gene Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression. Indicus|evm.model.CM009507.1.209 Q8WWY6 MB3L1_HUMAN 62.827 0.964286 1.01031 MBD3L1 - Methyl-CpG-binding domain protein 3-like 1 - Homo sapiens (Human) - MBD3L1 gene Transcriptional repressor. Indicus|evm.model.CM009507.1.210 Q9GKM4 BCAT1_SHEEP 86.979 0.956757 0.961039 BCAT1 - Branched-chain-amino-acid aminotransferase, cytosolic - Ovis aries (Sheep) - BCAT1 gene Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Indicus|evm.model.CM009507.1.211 E9PGG2 ANHX_HUMAN 70.251 0.571134 1.27968 ANHX - Anomalous homeobox protein - Homo sapiens (Human) - ANHX gene nucleus, transcription regulator complex, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, eye development, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009507.1.212 Q5RF77 CHFR_PONAB 89.474 0.170181 1.16287 CHFR - E3 ubiquitin-protein ligase CHFR - Pongo abelii (Sumatran orangutan) - CHFR gene E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. Indicus|evm.model.CM009507.1.213 Q08378 GOGA3_HUMAN 80.987 0.990391 0.97263 GOLGA3 - Golgin subfamily A member 3 - Homo sapiens (Human) - GOLGA3 gene Golgi auto-antigen; probably involved in maintaining Golgi structure. Indicus|evm.model.CM009507.1.214 Q86XL3 ANKL2_HUMAN 74.174 0.997925 1.02772 ANKLE2 - Ankyrin repeat and LEM domain-containing protein 2 - Homo sapiens (Human) - ANKLE2 gene Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). Indicus|evm.model.CM009507.1.215 Q96HS1 PGAM5_HUMAN 93.080 0.993103 1.00346 PGAM5 - Serine/threonine-protein phosphatase PGAM5, mitochondrial - Homo sapiens (Human) - PGAM5 gene Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. Indicus|evm.model.CM009507.1.216 Q2KIY1 PXMP2_BOVIN 100.000 0.989848 1.0051 PXMP2 - Peroxisomal membrane protein 2 - Bos taurus (Bovine) - PXMP2 gene Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane. Indicus|evm.model.CM009507.1.217 Q07864 DPOE1_HUMAN 90.495 0.993955 1.01312 POLE - DNA polymerase epsilon catalytic subunit A - Homo sapiens (Human) - POLE gene Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Indicus|evm.model.CM009507.1.218 Q9UBL9 P2RX2_HUMAN 88.220 0.915865 0.883227 P2RX2 - P2X purinoceptor 2 - Homo sapiens (Human) - P2RX2 gene Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. Indicus|evm.model.CM009507.1.219 A6NCL2 LRCL1_HUMAN 58.824 0.364964 0.861635 LRCOL1 - Leucine-rich colipase-like protein 1 precursor - Homo sapiens (Human) - LRCOL1 gene response to food Indicus|evm.model.CM009507.1.220 Q9HCM7 FBSL_HUMAN 90.000 0.0802721 0.703349 FBRSL1 - Fibrosin-1-like protein - Homo sapiens (Human) - FBRSL1 gene RNA binding Indicus|evm.model.CM009507.1.221 Q9HCM7 FBSL_HUMAN 82.558 0.134707 0.603828 FBRSL1 - Fibrosin-1-like protein - Homo sapiens (Human) - FBRSL1 gene RNA binding Indicus|evm.model.CM009507.1.224 Q9HCQ5 GALT9_HUMAN 91.136 0.724346 0.824212 GALNT9 - Polypeptide N-acetylgalactosaminyltransferase 9 - Homo sapiens (Human) - GALNT9 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3. Indicus|evm.model.CM009507.1.225 Q9BVI4 NOC4L_HUMAN 84.890 0.935567 0.751938 NOC4L - Nucleolar complex protein 4 homolog - Homo sapiens (Human) - NOC4L gene Noc4p-Nop14p complex, nucleolus, nucleoplasm, small-subunit processome, RNA binding, rRNA processing Indicus|evm.model.CM009507.1.226 Q8N8A6 DDX51_HUMAN 82.482 0.968142 0.848348 DDX51 - ATP-dependent RNA helicase DDX51 - Homo sapiens (Human) - DDX51 gene ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Indicus|evm.model.CM009507.1.227 Q9UET6 TRM7_HUMAN 89.189 0.992308 0.790274 FTSJ1 - Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase - Homo sapiens (Human) - FTSJ1 gene Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. Indicus|evm.model.CM009507.1.228 Q8CHI8 EP400_MOUSE 83.871 0.306175 1.00684 Ep400 - E1A-binding protein p400 - Mus musculus (Mouse) - Ep400 gene Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Regulates transcriptional activity of ZNF42. Indicus|evm.model.CM009507.1.229 Q9Y606 TRUA_HUMAN 81.754 0.970046 1.01639 PUS1 - tRNA pseudouridine synthase A precursor - Homo sapiens (Human) - PUS1 gene Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 RNA. Indicus|evm.model.CM009507.1.230 O75385 ULK1_HUMAN 90.341 0.998106 1.00571 ULK1 - Serine/threonine-protein kinase ULK1 - Homo sapiens (Human) - ULK1 gene Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Indicus|evm.model.CM009507.1.231 Q12872 SFSWA_HUMAN 90.491 0.555156 1.75394 SFSWAP - Splicing factor, suppressor of white-apricot homolog - Homo sapiens (Human) - SFSWAP gene Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. Indicus|evm.model.CM009507.1.233 A6QLU6 AGRD1_BOVIN 99.424 0.987472 0.973392 ADGRD1 - Adhesion G-protein coupled receptor D1 precursor - Bos taurus (Bovine) - ADGRD1 gene Orphan receptor. Signals via G(s)-alpha family of G-proteins. Indicus|evm.model.CM009507.1.236 P62828 RAN_RAT 100.000 0.755682 0.814815 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Indicus|evm.model.CM009507.1.237 Q00262 STX2_MOUSE 90.909 0.909722 0.99654 Stx2 - Syntaxin-2 - Mus musculus (Mouse) - Stx2 gene Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Indicus|evm.model.CM009507.1.238 O15034 RIMB2_HUMAN 91.538 0.173826 1.41635 RIMBP2 - RIMS-binding protein 2 - Homo sapiens (Human) - RIMBP2 gene Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. Indicus|evm.model.CM009507.1.239 Q9JMB7 PIWL1_MOUSE 98.028 0.99768 1 Piwil1 - Piwi-like protein 1 - Mus musculus (Mouse) - Piwil1 gene Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:11578866, PubMed:22121019, PubMed:21237665). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:11578866, PubMed:22121019, PubMed:21237665). Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:11578866, PubMed:22121019, PubMed:21237665). Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias) (PubMed:24757166). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle (PubMed:22121019). Acts as an endoribonuclease that cleaves transposon messenger RNAs (PubMed:22121019). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (PubMed:16938833). Probable component of some RISC complex, which mediates RNA cleavage and translational silencing (PubMed:16938833). Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (PubMed:16787948). Required to sequester RNF8 in the cytoplasm until late spermatogenesis; RNF8 being released upon ubiquitination and degradation of PIWIL1 (PubMed:28552346). Indicus|evm.model.CM009507.1.240 Q9ULW2 FZD10_HUMAN 95.181 0.996564 1.00172 FZD10 - Frizzled-10 precursor - Homo sapiens (Human) - FZD10 gene Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Indicus|evm.model.CM009507.1.244 Q76HP3 T132D_MOUSE 84.483 0.662791 0.0783956 Tmem132d - Transmembrane protein 132D precursor - Mus musculus (Mouse) - Tmem132d gene May serve as a cell-surface marker for oligodendrocyte differentiation. Indicus|evm.model.CM009507.1.245 Q14C87 T132D_HUMAN 84.906 0.593023 0.078253 TMEM132D - Transmembrane protein 132D precursor - Homo sapiens (Human) - TMEM132D gene May serve as a cell-surface marker for oligodendrocyte differentiation. Indicus|evm.model.CM009507.1.246 Q14C87 T132D_HUMAN 85.185 0.991987 0.567789 TMEM132D - Transmembrane protein 132D precursor - Homo sapiens (Human) - TMEM132D gene May serve as a cell-surface marker for oligodendrocyte differentiation. Indicus|evm.model.CM009507.1.247 Q5RAF1 GL1D1_PONAB 68.944 0.906355 0.864162 GLT1D1 - Glycosyltransferase 1 domain-containing protein 1 precursor - Pongo abelii (Sumatran orangutan) - GLT1D1 gene Indicus|evm.model.CM009507.1.248 A6QQL0 S15A4_BOVIN 100.000 0.995671 0.816254 SLC15A4 - Solute carrier family 15 member 4 - Bos taurus (Bovine) - SLC15A4 gene Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (By similarity). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (By similarity). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation. Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). Indicus|evm.model.CM009507.1.249 Q8N3T6 T132C_HUMAN 84.580 0.993856 0.587545 TMEM132C - Transmembrane protein 132C precursor - Homo sapiens (Human) - TMEM132C gene Indicus|evm.model.CM009507.1.250 Q5R893 H2B1_PONAB 95.050 0.917431 0.865079 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009507.1.252 Q8CEF9 T132C_MOUSE 81.319 0.671642 0.121929 Tmem132c - Transmembrane protein 132C precursor - Mus musculus (Mouse) - Tmem132c gene negative regulation of phosphatase activity Indicus|evm.model.CM009507.1.253 Q8N3T6 T132C_HUMAN 81.145 0.976898 0.273466 TMEM132C - Transmembrane protein 132C precursor - Homo sapiens (Human) - TMEM132C gene Indicus|evm.model.CM009507.1.254 Q14DG7 T132B_HUMAN 88.889 0.981651 0.101113 TMEM132B - Transmembrane protein 132B - Homo sapiens (Human) - TMEM132B gene Indicus|evm.model.CM009507.1.255 Q14DG7 T132B_HUMAN 59.756 0.91954 0.080705 TMEM132B - Transmembrane protein 132B - Homo sapiens (Human) - TMEM132B gene Indicus|evm.model.CM009507.1.257 O19110 TSPY1_BOVIN 59.322 0.664671 0.526814 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.258 O19110 TSPY1_BOVIN 66.667 0.564103 0.246057 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.259 P78395 PRAME_HUMAN 66.667 0.9625 0.157171 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009507.1.261 O19110 TSPY1_BOVIN 75.000 0.565476 0.529968 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.262 P61078 UB2D3_RAT 96.599 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009507.1.263 O19110 TSPY1_BOVIN 68.896 0.958904 0.921136 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.264 Q86YH2 Z280B_HUMAN 72.629 0.96817 0.694291 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Indicus|evm.model.CM009507.1.265 O19110 TSPY1_BOVIN 55.396 0.932432 0.466877 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.266 O19110 TSPY1_BOVIN 64.539 0.608696 0.725552 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.267 O19110 TSPY1_BOVIN 70.769 0.438356 0.460568 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.268 Q96LI6 HSFY1_HUMAN 60.234 0.505952 0.837905 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009507.1.269 P78395 PRAME_HUMAN 62.327 0.96374 1.02947 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009507.1.270 P78395 PRAME_HUMAN 65.445 0.974359 0.383104 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009507.1.271 O19110 TSPY1_BOVIN 68.421 0.0829596 1.40694 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.272 O19110 TSPY1_BOVIN 59.459 0.901639 0.384858 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.273 O19110 TSPY1_BOVIN 69.231 0.42953 0.470032 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.274 O19110 TSPY1_BOVIN 55.714 0.939189 0.466877 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009507.1.275 Q86YH2 Z280B_HUMAN 69.547 0.926357 0.475138 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Indicus|evm.model.CM009507.1.276 Q86YH2 Z280B_HUMAN 80.769 0.202756 0.935543 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Indicus|evm.model.CM009507.1.277 P62264 RS14_MOUSE 91.429 0.914474 1.00662 Rps14 - 40S ribosomal protein S14 - Mus musculus (Mouse) - Rps14 gene cytosol, cytosolic small ribosomal subunit, mitochondrion, nucleolus, postsynaptic density, mRNA 5'-UTR binding, RNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, translation regulator activity Indicus|evm.model.CM009507.1.278 P78395 PRAME_HUMAN 50.376 0.984962 0.261297 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009507.1.279 O95522 PRA12_HUMAN 56.452 0.243028 0.519669 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Indicus|evm.model.CM009507.1.280 Q86YH2 Z280B_HUMAN 59.744 0.874286 0.644567 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Indicus|evm.model.CM009507.1.281 Q13796 SHRM2_HUMAN 57.732 0.220779 0.238243 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Indicus|evm.model.CM009507.1.286 Q14DG7 T132B_HUMAN 90.199 0.553011 1.09369 TMEM132B - Transmembrane protein 132B - Homo sapiens (Human) - TMEM132B gene Indicus|evm.model.CM009507.1.287 Q9N0E1 AACS_MACFA 91.815 0.997028 1.00149 AACS - Acetoacetyl-CoA synthetase - Macaca fascicularis (Crab-eating macaque) - AACS gene Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). Indicus|evm.model.CM009507.1.288 Q8WY22 BRI3B_HUMAN 85.657 0.99177 0.968127 BRI3BP - BRI3-binding protein - Homo sapiens (Human) - BRI3BP gene Involved in tumorigenesis and may function by stabilizing p53/TP53. Indicus|evm.model.CM009507.1.289 Q8IY37 DHX37_HUMAN 85.233 0.99827 0.999136 DHX37 - Probable ATP-dependent RNA helicase DHX37 - Homo sapiens (Human) - DHX37 gene ATP-binding RNA helicase that plays a role in maturation of the small ribosomal subunit in ribosome biogenesis (PubMed:30582406). Required for the release of the U3 snoRNP from pre-ribosomal particles (PubMed:30582406). Plays a role in early testis development (PubMed:31287541, PubMed:31337883). Probably plays also a role in brain development (PubMed:31256877). Indicus|evm.model.CM009507.1.291 P0CH28 UBC_BOVIN 99.672 0.977492 0.450725 UBC - Polyubiquitin-C precursor - Bos taurus (Bovine) - UBC gene Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). Indicus|evm.model.CM009507.1.292 O18824 SCRB1_BOVIN 99.786 0.919132 0.996071 SCARB1 - Scavenger receptor class B member 1 - Bos taurus (Bovine) - SCARB1 gene Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Indicus|evm.model.CM009507.1.294 Q9WU42 NCOR2_MOUSE 87.406 0.212706 1.00607 Ncor2 - Nuclear receptor corepressor 2 - Mus musculus (Mouse) - Ncor2 gene Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Indicus|evm.model.CM009507.1.295 Q6ZTI6 RFLA_HUMAN 85.135 0.696682 0.976852 RFLNA - Refilin-A - Homo sapiens (Human) - RFLNA gene Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. Indicus|evm.model.CM009507.1.297 Q8N3J9 ZN664_HUMAN 100.000 0.909091 1.09579 ZNF664 - Zinc finger protein 664 - Homo sapiens (Human) - ZNF664 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009507.1.299 Q53HC0 CCD92_HUMAN 88.615 0.975904 1.00302 CCDC92 - Coiled-coil domain-containing protein 92 - Homo sapiens (Human) - CCDC92 gene centriole, centrosome, intracellular membrane-bounded organelle, nucleoplasm, identical protein binding Indicus|evm.model.CM009507.1.300 Q8IVF4 DYH10_HUMAN 90.664 0.89617 1.01029 DNAH10 - Dynein axonemal heavy chain 10 - Homo sapiens (Human) - DNAH10 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain. Indicus|evm.model.CM009507.1.301 O97681 VPP2_BOVIN 94.537 0.997773 1.05152 ATP6V0A2 - V-type proton ATPase 116 kDa subunit a2 - Bos taurus (Bovine) - ATP6V0A2 gene Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). Indicus|evm.model.CM009507.1.302 Q96GX1 TECT2_HUMAN 78.849 0.997114 0.994261 TCTN2 - Tectonic-2 precursor - Homo sapiens (Human) - TCTN2 gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity). Indicus|evm.model.CM009507.1.303 Q05B56 TF2H3_BOVIN 99.676 0.993548 1.00324 GTF2H3 - General transcription factor IIH subunit 3 - Bos taurus (Bovine) - GTF2H3 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Indicus|evm.model.CM009507.1.304 Q0IIF2 EI2BA_BOVIN 100.000 0.993464 1.00328 EIF2B1 - Translation initiation factor eIF-2B subunit alpha - Bos taurus (Bovine) - EIF2B1 gene Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Indicus|evm.model.CM009507.1.305 Q2NL08 DDX55_BOVIN 99.168 0.996678 1.00166 DDX55 - ATP-dependent RNA helicase DDX55 - Bos taurus (Bovine) - DDX55 gene Probable ATP-binding RNA helicase. Indicus|evm.model.CM009507.1.306 Q63524 TMED2_RAT 100.000 0.990099 1.00498 Tmed2 - Transmembrane emp24 domain-containing protein 2 precursor - Rattus norvegicus (Rat) - Tmed2 gene Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity). Indicus|evm.model.CM009507.1.307 Q17QG3 RIPL1_BOVIN 97.567 0.995146 1.02233 RILPL1 - RILP-like protein 1 - Bos taurus (Bovine) - RILPL1 gene Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (By similarity). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity). Indicus|evm.model.CM009507.1.308 Q1LZH0 U1SBP_BOVIN 100.000 0.99187 1.00408 SNRNP35 - U11/U12 small nuclear ribonucleoprotein 35 kDa protein - Bos taurus (Bovine) - SNRNP35 gene U12-type spliceosomal complex, mRNA binding, snRNA binding, mRNA splicing, via spliceosome Indicus|evm.model.CM009507.1.309 A4IFK7 RIPL2_BOVIN 100.000 0.990338 1.00485 RILPL2 - RILP-like protein 2 - Bos taurus (Bovine) - RILPL2 gene Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity). Indicus|evm.model.CM009507.1.310 Q2YDJ8 KMT5A_BOVIN 100.000 0.993243 0.840909 KMT5A - N-lysine methyltransferase KMT5A - Bos taurus (Bovine) - KMT5A gene Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. Indicus|evm.model.CM009507.1.311 A3KN83 SBNO1_HUMAN 98.132 0.955357 1.04523 SBNO1 - Protein strawberry notch homolog 1 - Homo sapiens (Human) - SBNO1 gene nucleus, chromatin DNA binding, histone binding, regulation of transcription, DNA-templated Indicus|evm.model.CM009507.1.312 O14519 CDKA1_HUMAN 100.000 0.977273 0.765217 CDK2AP1 - Cyclin-dependent kinase 2-associated protein 1 - Homo sapiens (Human) - CDK2AP1 gene specific inhibitor of the cell-cycle kinase CDK2. Indicus|evm.model.CM009507.1.313 Q9H3J6 CL065_HUMAN 85.455 0.982036 1.00602 MTRFR - Mitochondrial translation release factor in rescue precursor - Homo sapiens (Human) - MTRFR gene Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:33243891). As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891). Indicus|evm.model.CM009507.1.314 Q99550 MPP9_HUMAN 82.715 0.998309 1 MPHOSPH9 - M-phase phosphoprotein 9 - Homo sapiens (Human) - MPHOSPH9 gene centriole, Golgi apparatus, membrane Indicus|evm.model.CM009507.1.315 Q9BZ72 PITM2_HUMAN 87.704 0.998431 0.945145 PITPNM2 - Membrane-associated phosphatidylinositol transfer protein 2 - Homo sapiens (Human) - PITPNM2 gene Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. Indicus|evm.model.CM009507.1.316 Q66PJ3 AR6P4_HUMAN 84.167 0.991379 0.551069 ARL6IP4 - ADP-ribosylation factor-like protein 6-interacting protein 4 - Homo sapiens (Human) - ARL6IP4 gene Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA. Indicus|evm.model.CM009507.1.317 Q6N063 OGFD2_HUMAN 89.429 0.994302 1.00286 OGFOD2 - 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 - Homo sapiens (Human) - OGFOD2 gene Indicus|evm.model.CM009507.1.319 Q9NP78 ABCB9_HUMAN 92.857 0.997406 1.00653 ABCB9 - ABC-type oligopeptide transporter ABCB9 - Homo sapiens (Human) - ABCB9 gene ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation (PubMed:15863492, PubMed:17977821, PubMed:18434309, PubMed:22641697, PubMed:25646430, PubMed:30877195, PubMed:31417173, PubMed:30353140). Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers (PubMed:15863492, PubMed:25646430). Binds and transports smaller and larger peptides with the same affinity (PubMed:31417173). Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (PubMed:15863492, PubMed:17977821, PubMed:18434309). Indicus|evm.model.CM009507.1.320 Q8R0J7 VP37B_MOUSE 90.260 0.642857 0.835088 Vps37b - Vacuolar protein sorting-associated protein 37B - Mus musculus (Mouse) - Vps37b gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity). Indicus|evm.model.CM009507.1.321 O75146 HIP1R_HUMAN 91.284 0.998126 0.999064 HIP1R - Huntingtin-interacting protein 1-related protein - Homo sapiens (Human) - HIP1R gene Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. Indicus|evm.model.CM009507.1.322 Q6P9F0 CCD62_HUMAN 81.460 0.991163 0.99269 CCDC62 - Coiled-coil domain-containing protein 62 - Homo sapiens (Human) - CCDC62 gene Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. Indicus|evm.model.CM009507.1.323 Q2HJ47 DENR_BOVIN 99.495 0.98995 1.00505 DENR - Density-regulated protein - Bos taurus (Bovine) - DENR gene May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity). Indicus|evm.model.CM009507.1.324 P62975 UBIQ_RABIT 98.684 0.210674 4.68421 Ubiquitin - Oryctolagus cuniculus (Rabbit) Indicus|evm.model.CM009507.1.325 Q8TDS4 HCAR2_HUMAN 82.873 0.991758 1.00275 HCAR2 - Hydroxycarboxylic acid receptor 2 - Homo sapiens (Human) - HCAR2 gene Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Indicus|evm.model.CM009507.1.326 P50748 KNTC1_HUMAN 88.411 0.998189 1 KNTC1 - Kinetochore-associated protein 1 - Homo sapiens (Human) - KNTC1 gene Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Indicus|evm.model.CM009507.1.327 A6QLS2 RSRC2_BOVIN 100.000 0.328383 2.78621 RSRC2 - Arginine/serine-rich coiled-coil protein 2 - Bos taurus (Bovine) - RSRC2 gene Indicus|evm.model.CM009507.1.329 P30622 CLIP1_HUMAN 92.142 0.99861 1.0007 CLIP1 - CAP-Gly domain-containing linker protein 1 - Homo sapiens (Human) - CLIP1 gene Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Indicus|evm.model.CM009507.1.330 Q96AX1 VP33A_HUMAN 97.800 0.921875 1.07383 VPS33A - Vacuolar protein sorting-associated protein 33A - Homo sapiens (Human) - VPS33A gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770). Indicus|evm.model.CM009507.1.331 Q5RBH2 DBLOH_PONAB 89.167 0.991632 1 DIABLO - Diablo homolog, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - DIABLO gene Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity). inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity). Indicus|evm.model.CM009507.1.332 Q9C0J1 B3GN4_HUMAN 85.511 0.980447 0.94709 B3GNT4 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 - Homo sapiens (Human) - B3GNT4 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. Indicus|evm.model.CM009507.1.333 Q8N309 LRC43_HUMAN 68.976 0.9872 0.952744 LRRC43 - Leucine-rich repeat-containing protein 43 - Homo sapiens (Human) - LRRC43 gene Indicus|evm.model.CM009507.1.335 Q9HAP2 MLXIP_HUMAN 84.302 0.997669 0.933624 MLXIP - MLX-interacting protein - Homo sapiens (Human) - MLXIP gene Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. Indicus|evm.model.CM009507.1.336 Q4VC05 BCL7A_HUMAN 84.000 0.921296 1.02857 BCL7A - B-cell CLL/lymphoma 7 protein family member A - Homo sapiens (Human) - BCL7A gene negative regulation of transcription, DNA-templated Indicus|evm.model.CM009507.1.337 Q5RE88 CF251_PONAB 80.000 0.872289 1.07792 CFAP251 - Cilia- and flagella-associated protein 251 - Pongo abelii (Sumatran orangutan) - CFAP251 gene Involved in spermatozoa motility (By similarity). May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). Indicus|evm.model.CM009507.1.338 Q3SZ19 PSMD9_BOVIN 100.000 0.990991 1.00452 PSMD9 - 26S proteasome non-ATPase regulatory subunit 9 - Bos taurus (Bovine) - PSMD9 gene Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. Indicus|evm.model.CM009507.1.339 Q5EA20 HPPD_BOVIN 100.000 0.994924 1.00254 HPD - 4-hydroxyphenylpyruvate dioxygenase - Bos taurus (Bovine) - HPD gene Key enzyme in the degradation of tyrosine. Indicus|evm.model.CM009507.1.340 Q9UPS6 SET1B_HUMAN 95.113 0.308689 0.942523 SETD1B - Histone-lysine N-methyltransferase SETD1B - Homo sapiens (Human) - SETD1B gene Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro. Indicus|evm.model.CM009507.1.341 Q3SZA1 RHOF_BOVIN 99.078 0.990826 1.01395 RHOF - Rho-related GTP-binding protein RhoF precursor - Bos taurus (Bovine) - RHOF gene Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology (By similarity). Indicus|evm.model.CM009507.1.342 A6QPF8 T120B_BOVIN 100.000 0.994118 1.00295 TMEM120B - Transmembrane protein 120B - Bos taurus (Bovine) - TMEM120B gene Necessary for efficient adipogenesis. Does not show ion channel activity. Indicus|evm.model.CM009507.1.344 Q32KM6 MORN3_BOVIN 100.000 0.991736 1.00415 MORN3 - MORN repeat-containing protein 3 - Bos taurus (Bovine) - MORN3 gene Indicus|evm.model.CM009507.1.345 Q96D31 CRCM1_HUMAN 96.040 0.993421 1.00997 ORAI1 - Calcium release-activated calcium channel protein 1 - Homo sapiens (Human) - ORAI1 gene Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928, PubMed:20354224, PubMed:26956484). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901). Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion. Indicus|evm.model.CM009507.1.346 Q8NHM5 KDM2B_HUMAN 96.382 0.99084 0.980539 KDM2B - Lysine-specific demethylase 2B - Homo sapiens (Human) - KDM2B gene Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). Indicus|evm.model.CM009507.1.347 Q5E9J6 RNF34_BOVIN 100.000 0.994681 1.00267 RNF34 - E3 ubiquitin-protein ligase RNF34 - Bos taurus (Bovine) - RNF34 gene E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation. Indicus|evm.model.CM009507.1.348 Q5RE52 APC5_PONAB 97.086 0.997354 1.00132 ANAPC5 - Anaphase-promoting complex subunit 5 - Pongo abelii (Sumatran orangutan) - ANAPC5 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Indicus|evm.model.CM009507.1.349 Q96RR4 KKCC2_HUMAN 90.799 0.977586 0.986395 CAMKK2 - Calcium/calmodulin-dependent protein kinase kinase 2 - Homo sapiens (Human) - CAMKK2 gene Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. Indicus|evm.model.CM009507.1.350 Q5E9U1 P2RX4_BOVIN 98.969 0.994859 1.00258 P2RX4 - P2X purinoceptor 4 - Bos taurus (Bovine) - P2RX4 gene Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin (By similarity). Indicus|evm.model.CM009507.1.351 Q99572 P2RX7_HUMAN 80.168 0.996644 1.00168 P2RX7 - P2X purinoceptor 7 - Homo sapiens (Human) - P2RX7 gene Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206). Indicus|evm.model.CM009507.1.352 O35594 IFT81_MOUSE 89.941 0.996909 0.957101 Ift81 - Intraflagellar transport protein 81 homolog - Mus musculus (Mouse) - Ift81 gene Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Indicus|evm.model.CM009507.1.353 P11607 AT2A2_PIG 98.944 0.998082 1.00096 ATP2A2 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 - Sus scrofa (Pig) - ATP2A2 gene This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. Indicus|evm.model.CM009507.1.354 Q9WVM3 APC7_MOUSE 98.143 0.786611 0.846018 Anapc7 - Anaphase-promoting complex subunit 7 - Mus musculus (Mouse) - Anapc7 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Indicus|evm.model.CM009507.1.355 O15145 ARPC3_HUMAN 100.000 0.988827 1.00562 ARPC3 - Actin-related protein 2/3 complex subunit 3 - Homo sapiens (Human) - ARPC3 gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Indicus|evm.model.CM009507.1.356 Q0P5E2 GPN3_BOVIN 99.648 0.992982 1.00352 GPN3 - GPN-loop GTPase 3 - Bos taurus (Bovine) - GPN3 gene Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Indicus|evm.model.CM009507.1.357 Q3SZW6 F216A_BOVIN 98.805 0.992063 1.00398 FAM216A - Protein FAM216A - Bos taurus (Bovine) - FAM216A gene Indicus|evm.model.CM009507.1.358 Q9QZ88 VPS29_MOUSE 100.000 0.989071 1.00549 Vps29 - Vacuolar protein sorting-associated protein 29 - Mus musculus (Mouse) - Vps29 gene Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (By similarity). Acts also as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates or a phosphorylated peptide derived from retromer cargo (in vitro) (PubMed:21629666, PubMed:15965486). Indicus|evm.model.CM009507.1.359 Q5E9X8 RAD9B_BOVIN 98.321 0.978824 0.961538 RAD9B - Cell cycle checkpoint control protein RAD9B - Bos taurus (Bovine) - RAD9B gene checkpoint clamp complex, 3'-5' exonuclease activity, cellular response to ionizing radiation, DNA repair, DNA replication checkpoint, intra-S DNA damage checkpoint Indicus|evm.model.CM009507.1.360 Q8NI37 PPTC7_HUMAN 99.023 0.993506 1.01316 PPTC7 - Protein phosphatase PTC7 homolog precursor - Homo sapiens (Human) - PPTC7 gene Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:30267671). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (PubMed:30267671). Indicus|evm.model.CM009507.1.361 Q2MV58 TECT1_HUMAN 77.333 0.996661 1.02044 TCTN1 - Tectonic-1 precursor - Homo sapiens (Human) - TCTN1 gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity). Indicus|evm.model.CM009507.1.362 Q96D96 HVCN1_HUMAN 86.275 0.992095 0.92674 HVCN1 - Voltage-gated hydrogen channel 1 - Homo sapiens (Human) - HVCN1 gene Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. Indicus|evm.model.CM009507.1.363 P63088 PP1G_RAT 100.000 0.926036 1.04644 Ppp1cc - Serine/threonine-protein phosphatase PP1-gamma catalytic subunit - Rattus norvegicus (Rat) - Ppp1cc gene Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Indicus|evm.model.CM009507.1.364 Q2T9W3 CCD63_BOVIN 99.640 0.80786 1.23118 CCDC63 - Coiled-coil domain-containing protein 63 - Bos taurus (Bovine) - CCDC63 gene Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. Indicus|evm.model.CM009507.1.365 Q3SZE5 MLRV_BOVIN 99.394 0.841026 1.1747 MYL2 - Myosin regulatory light chain 2, ventricular/cardiac muscle isoform - Bos taurus (Bovine) - MYL2 gene Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). Indicus|evm.model.CM009507.1.366 O14529 CUX2_HUMAN 88.647 0.998675 1.01615 CUX2 - Homeobox protein cut-like 2 - Homo sapiens (Human) - CUX2 gene Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner. Indicus|evm.model.CM009507.1.367 Q8N4B1 SESQ1_HUMAN 57.212 0.905473 0.807229 PHETA1 - Sesquipedalian-1 - Homo sapiens (Human) - PHETA1 gene Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. Indicus|evm.model.CM009507.1.368 Q9UQQ2 SH2B3_HUMAN 89.320 0.993377 0.525217 SH2B3 - SH2B adapter protein 3 - Homo sapiens (Human) - SH2B3 gene Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. Indicus|evm.model.CM009507.1.369 Q99700 ATX2_HUMAN 93.333 0.998217 0.854532 ATXN2 - Ataxin-2 - Homo sapiens (Human) - ATXN2 gene Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. Indicus|evm.model.CM009507.1.370 Q7Z569 BRAP_HUMAN 96.284 0.996627 1.00169 BRAP - BRCA1-associated protein - Homo sapiens (Human) - BRAP gene Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. Indicus|evm.model.CM009507.1.371 Q6JQN1 ACD10_HUMAN 80.482 0.474713 0.82153 ACAD10 - Acyl-CoA dehydrogenase family member 10 - Homo sapiens (Human) - ACAD10 gene Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA. Indicus|evm.model.CM009507.1.372 Q6JQN1 ACD10_HUMAN 85.241 0.996212 0.997167 ACAD10 - Acyl-CoA dehydrogenase family member 10 - Homo sapiens (Human) - ACAD10 gene Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA. Indicus|evm.model.CM009507.1.373 P49025 CTRO_MOUSE 90.743 0.999023 0.996594 Cit - Citron Rho-interacting kinase - Mus musculus (Mouse) - Cit gene Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Probable RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. Indicus|evm.model.CM009507.1.374 Q5BIS9 AAKB1_BOVIN 100.000 0.99262 1.0037 PRKAB1 - 5'-AMP-activated protein kinase subunit beta-1 - Bos taurus (Bovine) - PRKAB1 gene Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). Indicus|evm.model.CM009507.1.375 B4DJY2 TM233_HUMAN 83.962 0.963303 1 TMEM233 - Transmembrane protein 233 - Homo sapiens (Human) - TMEM233 gene membrane Indicus|evm.model.CM009507.1.376 Q8IWA6 CCD60_HUMAN 82.299 0.992701 0.996364 CCDC60 - Coiled-coil domain-containing protein 60 - Homo sapiens (Human) - CCDC60 gene Indicus|evm.model.CM009507.1.377 Q5EAC9 HSPB8_BOVIN 100.000 0.989848 1.0051 HSPB8 - Heat shock protein beta-8 - Bos taurus (Bovine) - HSPB8 gene Displays temperature-dependent chaperone activity. Indicus|evm.model.CM009507.1.378 A7MD48 SRRM4_HUMAN 89.770 0.786184 0.99509 SRRM4 - Serine/arginine repetitive matrix protein 4 - Homo sapiens (Human) - SRRM4 gene Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:30684677). Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity). Indicus|evm.model.CM009507.1.379 A6H6W9 SDS3_BOVIN 98.476 0.98494 1.0122 SUDS3 - Sin3 histone deacetylase corepressor complex component SDS3 - Bos taurus (Bovine) - SUDS3 gene Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Indicus|evm.model.CM009507.1.380 Q9H2K8 TAOK3_HUMAN 97.884 0.997775 1.00111 TAOK3 - Serine/threonine-protein kinase TAO3 - Homo sapiens (Human) - TAOK3 gene Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Indicus|evm.model.CM009507.1.381 P13696 PEBP1_BOVIN 100.000 0.989362 1.00535 PEBP1 - Phosphatidylethanolamine-binding protein 1 - Bos taurus (Bovine) - PEBP1 gene Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Indicus|evm.model.CM009507.1.382 Q8N0Z9 VSI10_HUMAN 77.306 0.996296 1 VSIG10 - V-set and immunoglobulin domain-containing protein 10 precursor - Homo sapiens (Human) - VSIG10 gene cell-cell junction, integral component of plasma membrane, cell adhesion molecule binding, cell-cell adhesion Indicus|evm.model.CM009507.1.383 Q0V8J1 WSB2_BOVIN 100.000 0.995086 1.00246 WSB2 - WD repeat and SOCS box-containing protein 2 - Bos taurus (Bovine) - WSB2 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009507.1.384 P40937 RFC5_HUMAN 90.358 0.99449 1.06765 RFC5 - Replication factor C subunit 5 - Homo sapiens (Human) - RFC5 gene The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Indicus|evm.model.CM009507.1.385 Q6VAB6 KSR2_HUMAN 91.304 0.299559 0.238947 KSR2 - Kinase suppressor of Ras 2 - Homo sapiens (Human) - KSR2 gene Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Indicus|evm.model.CM009507.1.386 Q6VAB6 KSR2_HUMAN 97.959 0.617834 0.165263 KSR2 - Kinase suppressor of Ras 2 - Homo sapiens (Human) - KSR2 gene Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Indicus|evm.model.CM009507.1.387 Q6VAB6 KSR2_HUMAN 96.552 0.977401 0.186316 KSR2 - Kinase suppressor of Ras 2 - Homo sapiens (Human) - KSR2 gene Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Indicus|evm.model.CM009507.1.388 Q3UVC0 KSR2_MOUSE 91.803 0.342857 0.182482 Ksr2 - Kinase suppressor of Ras 2 - Mus musculus (Mouse) - Ksr2 gene Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Indicus|evm.model.CM009507.1.389 Q6VAB6 KSR2_HUMAN 100.000 0.185501 0.493684 KSR2 - Kinase suppressor of Ras 2 - Homo sapiens (Human) - KSR2 gene Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Indicus|evm.model.CM009507.1.390 P29475 NOS1_HUMAN 89.262 0.996241 0.927476 NOS1 - Nitric oxide synthase, brain - Homo sapiens (Human) - NOS1 gene Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Indicus|evm.model.CM009507.1.391 P0DL28 FBXW8_RAT 72.125 0.913738 0.525168 Fbxw8 - F-box/WD repeat-containing protein 8 - Rattus norvegicus (Rat) - Fbxw8 gene Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Indicus|evm.model.CM009507.1.392 P29475 NOS1_HUMAN 93.478 0.505618 0.0620642 NOS1 - Nitric oxide synthase, brain - Homo sapiens (Human) - NOS1 gene Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Indicus|evm.model.CM009507.1.393 O94952 FBX21_HUMAN 98.246 0.996815 1 FBXO21 - F-box only protein 21 - Homo sapiens (Human) - FBXO21 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009507.1.394 Q96BS2 CHP3_HUMAN 97.196 0.990698 1.00467 TESC - Calcineurin B homologous protein 3 - Homo sapiens (Human) - TESC gene Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. Indicus|evm.model.CM009507.1.395 Q8N3Y1 FBXW8_HUMAN 79.167 0.910326 0.615385 FBXW8 - F-box/WD repeat-containing protein 8 - Homo sapiens (Human) - FBXW8 gene Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). Indicus|evm.model.CM009507.1.396 Q96EX2 RNFT2_HUMAN 93.987 0.995556 1.01351 RNFT2 - RING finger and transmembrane domain-containing protein 2 - Homo sapiens (Human) - RNFT2 gene ubiquitin protein ligase activity Indicus|evm.model.CM009507.1.397 Q17QN8 SPRNG_BOVIN 100.000 0.990291 1.00488 SPRING - SREBP regulating gene protein - Bos taurus (Bovine) - SPRING gene Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP. Indicus|evm.model.CM009507.1.400 Q71F56 MD13L_HUMAN 96.342 0.965517 1.02353 MED13L - Mediator of RNA polymerase II transcription subunit 13-like - Homo sapiens (Human) - MED13L gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Indicus|evm.model.CM009507.1.405 O15119 TBX3_HUMAN 95.623 0.948636 0.838493 TBX3 - T-box transcription factor TBX3 - Homo sapiens (Human) - TBX3 gene Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. Indicus|evm.model.CM009507.1.406 Q99593 TBX5_HUMAN 97.495 0.996154 1.00386 TBX5 - T-box transcription factor TBX5 - Homo sapiens (Human) - TBX5 gene DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:25725155, PubMed:25963046, PubMed:29174768, PubMed:26917986, PubMed:27035640, PubMed:8988164). Binds to the core DNA motif of NPPA promoter (PubMed:26926761). Indicus|evm.model.CM009507.1.407 Q9Y4C8 RBM19_HUMAN 85.593 0.124072 0.982292 RBM19 - Probable RNA-binding protein 19 - Homo sapiens (Human) - RBM19 gene Plays a role in embryo pre-implantation development. Indicus|evm.model.CM009507.1.408 Q9H2C1 LHX5_HUMAN 99.005 0.995037 1.00249 LHX5 - LIM/homeobox protein Lhx5 - Homo sapiens (Human) - LHX5 gene Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system. Indicus|evm.model.CM009507.1.409 Q96GA7 SDSL_HUMAN 83.232 0.886179 1.12158 SDSL - Serine dehydratase-like - Homo sapiens (Human) - SDSL gene Has low serine dehydratase and threonine dehydratase activity. Indicus|evm.model.CM009507.1.410 Q0VCW4 SDHL_BOVIN 99.388 0.993902 1.00306 SDS - L-serine dehydratase/L-threonine deaminase - Bos taurus (Bovine) - SDS gene L-serine ammonia-lyase activity, L-threonine ammonia-lyase activity, protein homodimerization activity, pyridoxal phosphate binding, isoleucine biosynthetic process, L-serine catabolic process, pyruvate biosynthetic process, threonine catabolic process Indicus|evm.model.CM009507.1.411 Q2KIY5 PLBL2_BOVIN 99.830 0.99661 1.0017 PLBD2 - Putative phospholipase B-like 2 precursor - Bos taurus (Bovine) - PLBD2 gene Putative phospholipase. Indicus|evm.model.CM009507.1.412 Q61010 DTX1_MOUSE 98.953 0.383065 0.791069 Dtx1 - E3 ubiquitin-protein ligase DTX1 - Mus musculus (Mouse) - Dtx1 gene Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Indicus|evm.model.CM009507.1.413 O95294 RASL1_HUMAN 87.946 0.968974 1.04229 RASAL1 - RasGAP-activating-like protein 1 - Homo sapiens (Human) - RASAL1 gene Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Indicus|evm.model.CM009507.1.414 A6NFT4 CFA73_HUMAN 79.931 0.947368 0.987013 CFAP73 - Cilia- and flagella-associated protein 73 - Homo sapiens (Human) - CFAP73 gene May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. Indicus|evm.model.CM009507.1.415 Q8TDD1 DDX54_HUMAN 89.784 0.997719 0.99546 DDX54 - ATP-dependent RNA helicase DDX54 - Homo sapiens (Human) - DDX54 gene Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. Indicus|evm.model.CM009507.1.416 Q2HJ75 RITA1_BOVIN 100.000 0.5671 0.858736 RITA1 - RBPJ-interacting and tubulin-associated protein 1 - Bos taurus (Bovine) - RITA1 gene Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity). Indicus|evm.model.CM009507.1.417 Q17QH9 DRC10_BOVIN 99.324 0.995506 1.00225 IQCD - Dynein regulatory complex protein 10 - Bos taurus (Bovine) - IQCD gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Indicus|evm.model.CM009507.1.418 Q9ULQ1 TPC1_HUMAN 91.922 0.997552 1.00123 TPCN1 - Two pore calcium channel protein 1 - Homo sapiens (Human) - TPCN1 gene Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. Indicus|evm.model.CM009507.1.419 Q6J4K2 NCLX_HUMAN 79.459 0.99682 1.07705 SLC8B1 - Mitochondrial sodium/calcium exchanger protein precursor - Homo sapiens (Human) - SLC8B1 gene Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K(+) (PubMed:15060069). Indicus|evm.model.CM009507.1.420 F1N3B8 OAS2_BOVIN 98.605 0.858667 1.05042 OAS2 - 2'-5'-oligoadenylate synthase 2 - Bos taurus (Bovine) - OAS2 gene Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (By similarity). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity). Indicus|evm.model.CM009507.1.421 Q29599 OAS1_PIG 73.913 0.882051 1.11748 OAS1 - 2'-5'-oligoadenylate synthase 1 - Sus scrofa (Pig) - OAS1 gene Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. Indicus|evm.model.CM009507.1.422 P00973 OAS1_HUMAN 72.318 0.446512 1.6125 OAS1 - 2'-5'-oligoadenylate synthase 1 - Homo sapiens (Human) - OAS1 gene Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. Indicus|evm.model.CM009507.1.423 Q06846 RP3A_BOVIN 98.864 0.997147 0.995739 RPH3A - Rabphilin-3A - Bos taurus (Bovine) - RPH3A gene Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (PubMed:9450942). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone (By similarity). Indicus|evm.model.CM009507.1.424 Q06124 PTN11_HUMAN 98.988 0.996633 1.00169 PTPN11 - Tyrosine-protein phosphatase non-receptor type 11 - Homo sapiens (Human) - PTPN11 gene Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Indicus|evm.model.CM009507.1.425 Q58DQ3 RL6_BOVIN 99.652 0.993056 1.00348 RPL6 - 60S ribosomal protein L6 - Bos taurus (Bovine) - RPL6 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009507.1.426 Q9Y4D8 HECD4_HUMAN 96.933 0.910569 1.10811 HECTD4 - Probable E3 ubiquitin-protein ligase HECTD4 - Homo sapiens (Human) - HECTD4 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Indicus|evm.model.CM009507.1.427 Q58D05 TRAD1_BOVIN 99.457 0.857477 0.737931 TRAFD1 - TRAF-type zinc finger domain-containing protein 1 - Bos taurus (Bovine) - TRAFD1 gene Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). Indicus|evm.model.CM009507.1.428 P56747 CLD6_HUMAN 70.755 0.84 0.568182 CLDN6 - Claudin-6 - Homo sapiens (Human) - CLDN6 gene Plays a major role in tight junction-specific obliteration of the intercellular space. Indicus|evm.model.CM009507.1.429 Q14CX7 NAA25_HUMAN 96.744 0.985492 0.992798 NAA25 - N-alpha-acetyltransferase 25, NatB auxiliary subunit - Homo sapiens (Human) - NAA25 gene Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression. Indicus|evm.model.CM009507.1.430 P81623 ERP29_BOVIN 100.000 0.992278 1.00388 ERP29 - Endoplasmic reticulum resident protein 29 precursor - Bos taurus (Bovine) - ERP29 gene Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the ER (By similarity). Indicus|evm.model.CM009507.1.431 Q8NCL8 TM116_HUMAN 81.557 0.612091 1.62041 TMEM116 - Transmembrane protein 116 - Homo sapiens (Human) - TMEM116 gene Indicus|evm.model.CM009507.1.432 P24049 RL17_RAT 91.473 0.984615 0.706522 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009507.1.433 Q60813 ADM1A_MOUSE 59.889 0.876528 1.03413 Adam1a - Disintegrin and metalloproteinase domain-containing protein 1a precursor - Mus musculus (Mouse) - Adam1a gene May be involved in sperm-egg fusion. Indicus|evm.model.CM009507.1.434 Q60813 ADM1A_MOUSE 61.918 0.764768 1.19848 Adam1a - Disintegrin and metalloproteinase domain-containing protein 1a precursor - Mus musculus (Mouse) - Adam1a gene May be involved in sperm-egg fusion. Indicus|evm.model.CM009507.1.435 Q8IW41 MAPK5_HUMAN 97.447 0.991507 0.995772 MAPKAPK5 - MAP kinase-activated protein kinase 5 - Homo sapiens (Human) - MAPKAPK5 gene Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. Indicus|evm.model.CM009507.1.436 P20000 ALDH2_BOVIN 100.000 0.996161 1.00192 ALDH2 - Aldehyde dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ALDH2 gene aldehyde dehydrogenase (NAD+) activity, NAD binding Indicus|evm.model.CM009507.1.438 Q6ZP65 BICL1_HUMAN 86.356 0.996678 1.05061 BICDL1 - BICD family-like cargo adapter 1 - Homo sapiens (Human) - BICDL1 gene Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity). Indicus|evm.model.CM009507.1.439 Q5U316 RAB35_RAT 85.027 0.829897 0.965174 Rab35 - Ras-related protein Rab-35 - Rattus norvegicus (Rat) - Rab35 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (By similarity). Indicus|evm.model.CM009507.1.440 Q92616 GCN1_HUMAN 96.181 0.999251 1.00037 GCN1 - eIF-2-alpha kinase activator GCN1 - Homo sapiens (Human) - GCN1 gene Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Indicus|evm.model.CM009507.1.441 Q95140 RLA0_BOVIN 99.686 0.99373 1.00314 RPLP0 - 60S acidic ribosomal protein P0 - Bos taurus (Bovine) - RPLP0 gene Ribosomal protein P0 is the functional equivalent of E.coli protein L10. Indicus|evm.model.CM009507.1.442 P49023 PAXI_HUMAN 89.138 0.964539 0.954315 PXN - Paxillin - Homo sapiens (Human) - PXN gene Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Indicus|evm.model.CM009507.1.443 Q1JQC6 SIR4_BOVIN 99.683 0.993671 1.00317 SIRT4 - NAD-dependent protein lipoamidase sirtuin-4, mitochondrial precursor - Bos taurus (Bovine) - SIRT4 gene Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion (By similarity). Indicus|evm.model.CM009507.1.444 O43347 MSI1H_HUMAN 97.638 0.735465 0.950276 MSI1 - RNA-binding protein Musashi homolog 1 - Homo sapiens (Human) - MSI1 gene RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). Indicus|evm.model.CM009507.1.445 P13182 CX6A1_BOVIN 99.083 0.603352 1.6422 COX6A1 - Cytochrome c oxidase subunit 6A1, mitochondrial precursor - Bos taurus (Bovine) - COX6A1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009507.1.446 Q9D8Z2 TRIA1_MOUSE 98.684 0.824176 1.19737 Triap1 - TP53-regulated inhibitor of apoptosis 1 - Mus musculus (Mouse) - Triap1 gene Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. Indicus|evm.model.CM009507.1.447 Q2KIF1 GATC_BOVIN 100.000 0.985401 1.00735 GATC - Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial precursor - Bos taurus (Bovine) - GATC gene Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Indicus|evm.model.CM009507.1.448 Q9D0B0 SRSF9_MOUSE 98.182 0.986486 1 Srsf9 - Serine/arginine-rich splicing factor 9 - Mus musculus (Mouse) - Srsf9 gene Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 (By similarity). Indicus|evm.model.CM009507.1.449 P63170 DYL1_RAT 100.000 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Indicus|evm.model.CM009507.1.450 Q0P5A2 COQ5_BOVIN 99.697 0.950867 1.04848 COQ5 - 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor - Bos taurus (Bovine) - COQ5 gene Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). Indicus|evm.model.CM009507.1.451 Q08E13 RNF10_BOVIN 99.877 0.997534 1.00123 RNF10 - RING finger protein 10 - Bos taurus (Bovine) - RNF10 gene Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination. Indicus|evm.model.CM009507.1.452 Q1JQ92 POP5_BOVIN 100.000 0.988304 1.00588 POP5 - Ribonuclease P/MRP protein subunit POP5 - Bos taurus (Bovine) - POP5 gene Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Indicus|evm.model.CM009507.1.453 Q9NZU7 CABP1_HUMAN 100.000 0.583012 0.7 CABP1 - Calcium-binding protein 1 - Homo sapiens (Human) - CABP1 gene Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity). Indicus|evm.model.CM009507.1.454 Q14165 MLEC_HUMAN 94.178 0.992958 0.972603 MLEC - Malectin precursor - Homo sapiens (Human) - MLEC gene Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity). Indicus|evm.model.CM009507.1.455 A6NIH7 U119B_HUMAN 92.520 0.992157 1.01594 UNC119B - Protein unc-119 homolog B - Homo sapiens (Human) - UNC119B gene Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells. Indicus|evm.model.CM009507.1.456 Q3ZBF6 ACADS_BOVIN 98.544 0.995122 0.995146 ACADS - Short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACADS gene Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:6712627). Indicus|evm.model.CM009507.1.457 Q9CUS9 SPPL3_MOUSE 99.740 0.994805 1.0026 Sppl3 - Signal peptide peptidase-like 3 - Mus musculus (Mouse) - Sppl3 gene Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971). Indicus|evm.model.CM009507.1.458 P20823 HNF1A_HUMAN 95.261 0.996845 1.00475 HNF1A - Hepatocyte nuclear factor 1-alpha - Homo sapiens (Human) - HNF1A gene Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:12453420, PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). Indicus|evm.model.CM009507.1.459 Q58CQ0 CSTOS_BOVIN 98.444 0.992248 1.00389 CUSTOS - Protein CUSTOS - Bos taurus (Bovine) - CUSTOS gene Plays a role in the regulation of Wnt signaling pathway during early development. Indicus|evm.model.CM009507.1.460 Q15646 OASL_HUMAN 59.557 0.995798 0.92607 OASL - 2'-5'-oligoadenylate synthase-like protein - Homo sapiens (Human) - OASL gene Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. Indicus|evm.model.CM009507.1.461 Q3SYA9 P12L1_HUMAN 48.182 0.170886 1.47664 POM121L1P - Putative POM121-like protein 1 - Homo sapiens (Human) - POM121L1P gene Indicus|evm.model.CM009507.1.464 Q8IZ07 AN13A_HUMAN 93.559 0.996616 1.00169 ANKRD13A - Ankyrin repeat domain-containing protein 13A - Homo sapiens (Human) - ANKRD13A gene Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. Indicus|evm.model.CM009507.1.465 Q14161 GIT2_HUMAN 95.916 0.997368 1.00132 GIT2 - ARF GTPase-activating protein GIT2 - Homo sapiens (Human) - GIT2 gene GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Indicus|evm.model.CM009507.1.467 Q5RE49 TCHP_PONAB 84.800 0.996008 1.00602 TCHP - Trichoplein keratin filament-binding protein - Pongo abelii (Sumatran orangutan) - TCHP gene Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Indicus|evm.model.CM009507.1.468 P68266 GLTP_PIG 99.522 0.990476 1.00478 GLTP - Glycolipid transfer protein - Sus scrofa (Pig) - GLTP gene Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides (By similarity). Indicus|evm.model.CM009507.1.469 Q9HBA0 TRPV4_HUMAN 96.785 0.997706 1.00115 TRPV4 - Transient receptor potential cation channel subfamily V member 4 - Homo sapiens (Human) - TRPV4 gene Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501). Indicus|evm.model.CM009507.1.470 Q5U5X8 F222A_HUMAN 93.846 0.53527 0.533186 FAM222A - Protein FAM222A - Homo sapiens (Human) - FAM222A gene Indicus|evm.model.CM009507.1.472 Q5E9T8 KIME_BOVIN 99.495 0.873894 1.14141 MVK - Mevalonate kinase - Bos taurus (Bovine) - MVK gene Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis. Indicus|evm.model.CM009507.1.473 Q58D49 MMAB_BOVIN 85.714 0.8583 1.0249 MMAB - Corrinoid adenosyltransferase precursor - Bos taurus (Bovine) - MMAB gene Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA. Indicus|evm.model.CM009507.1.474 Q7Z3V4 UBE3B_HUMAN 95.693 0.987049 1.01217 UBE3B - Ubiquitin-protein ligase E3B - Homo sapiens (Human) - UBE3B gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Indicus|evm.model.CM009507.1.475 Q9H3F6 BACD3_HUMAN 99.051 0.993691 1.01278 KCTD10 - BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 - Homo sapiens (Human) - KCTD10 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity). Indicus|evm.model.CM009507.1.476 Q8N1T3 MYO1H_HUMAN 89.389 0.90146 1.06202 MYO1H - Unconventional myosin-Ih - Homo sapiens (Human) - MYO1H gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Indicus|evm.model.CM009507.1.477 Q96NZ1 FOXN4_HUMAN 90.347 0.968165 1.03288 FOXN4 - Forkhead box protein N4 - Homo sapiens (Human) - FOXN4 gene Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity). Indicus|evm.model.CM009507.1.478 O00763 ACACB_HUMAN 89.875 0.992911 0.918226 ACACB - Acetyl-CoA carboxylase 2 precursor - Homo sapiens (Human) - ACACB gene Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:19900410, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). Indicus|evm.model.CM009507.1.479 O00763 ACACB_HUMAN 60.104 0.989583 0.0781123 ACACB - Acetyl-CoA carboxylase 2 precursor - Homo sapiens (Human) - ACACB gene Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:19900410, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). Indicus|evm.model.CM009507.1.480 P13051 UNG_HUMAN 91.720 0.993631 1.00319 UNG - Uracil-DNA glycosylase - Homo sapiens (Human) - UNG gene Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Indicus|evm.model.CM009507.1.481 Q58DM4 ALKB2_BOVIN 99.640 0.992832 1.0036 ALKBH2 - DNA oxidative demethylase ALKBH2 - Bos taurus (Bovine) - ALKBH2 gene Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Indicus|evm.model.CM009507.1.482 Q70CQ3 UBP30_HUMAN 91.296 0.996139 1.00193 USP30 - Ubiquitin carboxyl-terminal hydrolase 30 - Homo sapiens (Human) - USP30 gene Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). Indicus|evm.model.CM009507.1.483 Q1JP63 SVOP_BOVIN 99.818 0.996357 1.00182 SVOP - Synaptic vesicle 2-related protein - Bos taurus (Bovine) - SVOP gene Indicus|evm.model.CM009507.1.484 P00371 OXDA_PIG 90.490 0.994253 1.00288 DAO - D-amino-acid oxidase - Sus scrofa (Pig) - DAO gene Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. Indicus|evm.model.CM009507.1.485 Q8WYL5 SSH1_HUMAN 81.660 0.988235 0.972355 SSH1 - Protein phosphatase Slingshot homolog 1 - Homo sapiens (Human) - SSH1 gene Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. Indicus|evm.model.CM009507.1.486 Q9ULV4 COR1C_HUMAN 98.734 0.925636 1.07806 CORO1C - Coronin-1C - Homo sapiens (Human) - CORO1C gene Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). Indicus|evm.model.CM009507.1.487 Q14242 SELPL_HUMAN 44.548 0.96729 1.03883 SELPLG - P-selectin glycoprotein ligand 1 precursor - Homo sapiens (Human) - SELPLG gene A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. Indicus|evm.model.CM009507.1.488 Q4V9L6 TM119_HUMAN 73.702 0.993056 1.01767 TMEM119 - Transmembrane protein 119 precursor - Homo sapiens (Human) - TMEM119 gene Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). Indicus|evm.model.CM009507.1.489 Q15020 SART3_HUMAN 84.866 0.962319 0.716511 SART3 - Squamous cell carcinoma antigen recognized by T-cells 3 - Homo sapiens (Human) - SART3 gene U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). Indicus|evm.model.CM009507.1.490 Q9BVA6 FICD_HUMAN 90.611 0.851024 1.17249 FICD - Protein adenylyltransferase FICD - Homo sapiens (Human) - FICD gene Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083). Indicus|evm.model.CM009507.1.491 Q5REG1 SART3_PONAB 94.081 0.963746 0.337411 SART3 - Squamous cell carcinoma antigen recognized by T-cells 3 - Pongo abelii (Sumatran orangutan) - SART3 gene U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair. May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC. Indicus|evm.model.CM009507.1.492 Q9H1K1 ISCU_HUMAN 97.605 0.988095 1.00599 ISCU - Iron-sulfur cluster assembly enzyme ISCU, mitochondrial precursor - Homo sapiens (Human) - ISCU gene Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity). Indicus|evm.model.CM009507.1.493 B9VR26 CML1_BOVIN 99.448 0.99449 1.00276 CMLKR1 - Chemokine-like receptor 1 - Bos taurus (Bovine) - CMLKR1 gene Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity). Indicus|evm.model.CM009507.1.494 Q2TBF2 WSCD2_HUMAN 95.044 0.99646 1 WSCD2 - WSC domain-containing protein 2 - Homo sapiens (Human) - WSCD2 gene Indicus|evm.model.CM009507.1.495 Q3SYA9 P12L1_HUMAN 45.902 0.542601 1.04206 POM121L1P - Putative POM121-like protein 1 - Homo sapiens (Human) - POM121L1P gene Indicus|evm.model.CM009507.1.496 Q7Z3Z3 PIWL3_HUMAN 54.657 0.934732 0.972789 PIWIL3 - Piwi-like protein 3 - Homo sapiens (Human) - PIWIL3 gene May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indicus|evm.model.CM009507.1.497 Q8BPQ7 SGSM1_MOUSE 93.482 0.97192 1.01006 Sgsm1 - Small G protein signaling modulator 1 - Mus musculus (Mouse) - Sgsm1 gene Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B. Indicus|evm.model.CM009507.1.498 Q6ICI0 TM211_HUMAN 77.000 0.99005 1.005 TMEM211 - Transmembrane protein 211 - Homo sapiens (Human) - TMEM211 gene membrane Indicus|evm.model.CM009507.1.499 Q9BY89 K1671_HUMAN 56.282 0.979791 0.849391 KIAA1671 - Uncharacterized protein KIAA1671 - Homo sapiens (Human) - KIAA1671 gene Indicus|evm.model.CM009507.1.500 Q9BY89 K1671_HUMAN 81.395 0.760204 0.217054 KIAA1671 - Uncharacterized protein KIAA1671 - Homo sapiens (Human) - KIAA1671 gene Indicus|evm.model.CM009507.1.501 P19141 CRBB3_BOVIN 100.000 0.990566 1.00474 CRYBB3 - Beta-crystallin B3 - Bos taurus (Bovine) - CRYBB3 gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009507.1.502 P02522 CRBB2_BOVIN 100.000 0.990291 1.00488 CRYBB2 - Beta-crystallin B2 - Bos taurus (Bovine) - CRYBB2 gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009507.1.503 P26818 ARBK2_BOVIN 100.000 0.996909 0.940407 GRK3 - Beta-adrenergic receptor kinase 2 - Bos taurus (Bovine) - GRK3 gene Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Indicus|evm.model.CM009507.1.504 Q8IUG5 MY18B_HUMAN 66.614 0.98473 0.943903 MYO18B - Unconventional myosin-XVIIIb - Homo sapiens (Human) - MYO18B gene May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. Indicus|evm.model.CM009507.1.505 Q9BYH1 SE6L1_HUMAN 85.277 0.862628 1.14453 SEZ6L - Seizure 6-like protein precursor - Homo sapiens (Human) - SEZ6L gene May contribute to specialized endoplasmic reticulum functions in neurons. Indicus|evm.model.CM009507.1.506 Q6ICH7 ASPH2_HUMAN 91.837 0.994186 0.932249 ASPHD2 - Aspartate beta-hydroxylase domain-containing protein 2 - Homo sapiens (Human) - ASPHD2 gene May function as 2-oxoglutarate-dependent dioxygenase. Indicus|evm.model.CM009507.1.507 Q9NQG7 HPS4_HUMAN 65.120 0.997067 0.963277 HPS4 - Hermansky-Pudlak syndrome 4 protein - Homo sapiens (Human) - HPS4 gene Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991). Indicus|evm.model.CM009507.1.508 Q9UH36 SRR1L_HUMAN 68.153 0.930931 0.982301 SRRD - SRR1-like protein - Homo sapiens (Human) - SRRD gene Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. Indicus|evm.model.CM009507.1.509 Q29RR5 TFP11_BOVIN 99.881 0.997613 1.00119 TFIP11 - Tuftelin-interacting protein 11 - Bos taurus (Bovine) - TFIP11 gene Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity). Indicus|evm.model.CM009507.1.510 Q3SYY2 TPST2_BOVIN 89.563 0.89738 1.21485 TPST2 - Protein-tyrosine sulfotransferase 2 - Bos taurus (Bovine) - TPST2 gene Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. Indicus|evm.model.CM009507.1.512 P07318 CRBB1_BOVIN 99.482 0.872727 0.869565 CRYBB1 - Beta-crystallin B1 - Bos taurus (Bovine) - CRYBB1 gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009507.1.513 P11842 CRBA4_BOVIN 100.000 0.989848 0.938095 CRYBA4 - Beta-crystallin A4 - Bos taurus (Bovine) - CRYBA4 gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009507.1.515 Q4FZT6 H2A3_RAT 98.462 0.984733 1.00769 Histone H2A type 3 - Rattus norvegicus (Rat) Indicus|evm.model.CM009507.1.518 Q10571 MN1_HUMAN 91.755 0.329505 0.857576 MN1 - Transcriptional activator MN1 - Homo sapiens (Human) - MN1 gene Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). Indicus|evm.model.CM009507.1.519 Q9TR36 PIPNB_BOVIN 100.000 0.992647 1.00369 PITPNB - Phosphatidylinositol transfer protein beta isoform - Bos taurus (Bovine) - PITPNB gene Catalyzes the transfer of phosphatidylinositol, phosphatidylcholine and sphingomyelin between membranes (PubMed:7654206). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity). Indicus|evm.model.CM009507.1.521 Q96AY4 TTC28_HUMAN 93.951 0.998299 0.948005 TTC28 - Tetratricopeptide repeat protein 28 - Homo sapiens (Human) - TTC28 gene During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. Indicus|evm.model.CM009507.1.522 Q96AY4 TTC28_HUMAN 97.849 0.989247 0.0374849 TTC28 - Tetratricopeptide repeat protein 28 - Homo sapiens (Human) - TTC28 gene During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. Indicus|evm.model.CM009507.1.523 O96017 CHK2_HUMAN 82.288 0.994393 0.985267 CHEK2 - Serine/threonine-protein kinase Chk2 - Homo sapiens (Human) - CHEK2 gene Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Indicus|evm.model.CM009507.1.524 Q8IWL3 HSC20_HUMAN 83.830 0.991525 1.00426 HSCB - Iron-sulfur cluster co-chaperone protein HscB - Homo sapiens (Human) - HSCB gene Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm (PubMed:20668094, PubMed:29309586). Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain (PubMed:26749241). Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (PubMed:26749241). Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1 (PubMed:29309586). This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT (PubMed:29309586). Indicus|evm.model.CM009507.1.525 Q8IWD4 CC117_HUMAN 88.172 0.992832 1 CCDC117 - Coiled-coil domain-containing protein 117 - Homo sapiens (Human) - CCDC117 gene Indicus|evm.model.CM009507.1.526 Q3SZZ2 XBP1_BOVIN 100.000 0.446809 1.44061 XBP1 - X-box-binding protein 1 - Bos taurus (Bovine) - XBP1 gene Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes. Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention. Indicus|evm.model.CM009507.1.528 Q9ULT6 ZNRF3_HUMAN 99.170 0.385233 0.665598 ZNRF3 - E3 ubiquitin-protein ligase ZNRF3 precursor - Homo sapiens (Human) - ZNRF3 gene E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity). Indicus|evm.model.CM009507.1.529 O95567 CV031_HUMAN 73.684 0.898413 1.08621 C22orf31 - Uncharacterized protein C22orf31 - Homo sapiens (Human) - C22orf31 gene Indicus|evm.model.CM009507.1.530 Q96MU8 KREM1_HUMAN 87.982 0.779006 1.14799 KREMEN1 - Kremen protein 1 precursor - Homo sapiens (Human) - KREMEN1 gene Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification. Indicus|evm.model.CM009507.1.531 Q96A84 EMID1_HUMAN 76.134 0.994094 1.15193 EMID1 - EMI domain-containing protein 1 precursor - Homo sapiens (Human) - EMID1 gene Indicus|evm.model.CM009507.1.532 Q9Y3P4 RHBD3_HUMAN 83.420 0.912322 1.09326 RHBDD3 - Rhomboid domain-containing protein 3 - Homo sapiens (Human) - RHBDD3 gene serine-type endopeptidase activity Indicus|evm.model.CM009507.1.533 Q01844 EWS_HUMAN 98.628 0.996951 1 EWSR1 - RNA-binding protein EWS - Homo sapiens (Human) - EWSR1 gene Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. Indicus|evm.model.CM009507.1.534 Q99501 GA2L1_HUMAN 89.883 0.997059 0.998532 GAS2L1 - GAS2-like protein 1 - Homo sapiens (Human) - GAS2L1 gene Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Indicus|evm.model.CM009507.1.535 Q92737 RSLAA_HUMAN 98.030 0.990196 1.00493 RASL10A - Ras-like protein family member 10A precursor - Homo sapiens (Human) - RASL10A gene Potent inhibitor of cellular proliferation. Indicus|evm.model.CM009507.1.536 Q10567 AP1B1_HUMAN 96.207 0.997872 0.990516 AP1B1 - AP-1 complex subunit beta-1 - Homo sapiens (Human) - AP1B1 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed:31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Indicus|evm.model.CM009507.1.538 P12036 NFH_HUMAN 80.054 0.996255 1.04094 NEFH - Neurofilament heavy polypeptide - Homo sapiens (Human) - NEFH gene Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). Indicus|evm.model.CM009507.1.539 A4IFQ0 THOC5_BOVIN 99.707 0.997076 1.00146 THOC5 - THO complex subunit 5 homolog - Bos taurus (Bovine) - THOC5 gene Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (By similarity). Indicus|evm.model.CM009507.1.540 Q9BPW8 NIPS1_HUMAN 95.775 0.992982 1.00352 NIPSNAP1 - Protein NipSnap homolog 1 - Homo sapiens (Human) - NIPSNAP1 gene mitochondrion, sensory perception of pain Indicus|evm.model.CM009507.1.541 P59750 MERL_PAPAN 98.154 0.99665 1.00336 NF2 - Merlin - Papio anubis (Olive baboon) - NF2 gene Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Indicus|evm.model.CM009507.1.543 Q66H96 CABP7_RAT 100.000 0.987097 0.72093 Cabp7 - Calcium-binding protein 7 - Rattus norvegicus (Rat) - Cabp7 gene Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Indicus|evm.model.CM009507.1.544 Q2TA39 ZMAT5_BOVIN 99.412 0.988304 1.00588 ZMAT5 - Zinc finger matrin-type protein 5 - Bos taurus (Bovine) - ZMAT5 gene U12-type spliceosomal complex Indicus|evm.model.CM009507.1.545 P00130 QCR9_BOVIN 98.438 0.969231 1.01562 UQCR10 - Cytochrome b-c1 complex subunit 9 - Bos taurus (Bovine) - UQCR10 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Indicus|evm.model.CM009507.1.546 Q9H1I8 ASCC2_HUMAN 87.583 0.997326 0.988111 ASCC2 - Activating signal cointegrator 1 complex subunit 2 - Homo sapiens (Human) - ASCC2 gene Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Indicus|evm.model.CM009507.1.547 Q13615 MTMR3_HUMAN 89.268 0.998324 0.995826 MTMR3 - Myotubularin-related protein 3 - Homo sapiens (Human) - MTMR3 gene Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:11676921). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11676921). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931). Indicus|evm.model.CM009507.1.548 A6QQY4 HORM2_BOVIN 99.020 0.993485 1.00327 HORMAD2 - HORMA domain-containing protein 2 - Bos taurus (Bovine) - HORMAD2 gene Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity). Indicus|evm.model.CM009507.1.549 Q27956 LIF_BOVIN 99.497 0.965854 1.01485 LIF - Leukemia inhibitory factor precursor - Bos taurus (Bovine) - LIF gene LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes (By similarity). Indicus|evm.model.CM009507.1.550 P53346 ONCM_BOVIN 97.881 0.987395 0.971429 OSM - Oncostatin-M precursor - Bos taurus (Bovine) - OSM gene Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST) (By similarity). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). Indicus|evm.model.CM009507.1.551 Q0V8A3 CAST1_BOVIN 100.000 0.993939 1.00304 CASTOR1 - Cytosolic arginine sensor for mTORC1 subunit 1 - Bos taurus (Bovine) - CASTOR1 gene Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. Indicus|evm.model.CM009507.1.552 Q9BXI6 TB10A_HUMAN 89.749 0.975391 0.879921 TBC1D10A - TBC1 domain family member 10A - Homo sapiens (Human) - TBC1D10A gene Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A. Indicus|evm.model.CM009507.1.553 A2VDN6 SF3A1_BOVIN 100.000 0.997481 1.00126 SF3A1 - Splicing factor 3A subunit 1 - Bos taurus (Bovine) - SF3A1 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. Indicus|evm.model.CM009507.1.555 A4IFI1 CC157_BOVIN 95.080 0.997054 0.986919 CCDC157 - Coiled-coil domain-containing protein 157 - Bos taurus (Bovine) - CCDC157 gene Indicus|evm.model.CM009507.1.556 Q9Y6U7 RN215_HUMAN 93.617 0.992933 0.750663 RNF215 - RING finger protein 215 - Homo sapiens (Human) - RNF215 gene endosome, Golgi transport complex, membrane, trans-Golgi network, ubiquitin protein ligase activity, Golgi to vacuole transport, protein targeting to vacuole, ubiquitin-dependent protein catabolic process Indicus|evm.model.CM009507.1.558 P58875 S14L2_BOVIN 99.752 0.99505 1.00248 SEC14L2 - SEC14-like protein 2 - Bos taurus (Bovine) - SEC14L2 gene Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (By similarity). Indicus|evm.model.CM009507.1.559 Q9UDX5 MTFP1_HUMAN 90.964 0.988024 1.00602 MTFP1 - Mitochondrial fission process protein 1 - Homo sapiens (Human) - MTFP1 gene Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis. Indicus|evm.model.CM009507.1.560 Q9Z1J8 S14L3_RAT 96.250 0.995012 1.0025 Sec14l3 - SEC14-like protein 3 - Rattus norvegicus (Rat) - Sec14l3 gene Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids. Indicus|evm.model.CM009507.1.561 Q9UDX3 S14L4_HUMAN 82.759 0.467128 2.13547 SEC14L4 - SEC14-like protein 4 - Homo sapiens (Human) - SEC14L4 gene Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids. Indicus|evm.model.CM009507.1.562 A6QNK1 G3ST1_BOVIN 95.161 0.968254 0.148936 GAL3ST1 - Galactosylceramide sulfotransferase - Bos taurus (Bovine) - GAL3ST1 gene Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates to the biosynthesis of sulfoglycolipids. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). Indicus|evm.model.CM009507.1.563 A6QNK1 G3ST1_BOVIN 99.527 0.995283 1.00236 GAL3ST1 - Galactosylceramide sulfotransferase - Bos taurus (Bovine) - GAL3ST1 gene Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates to the biosynthesis of sulfoglycolipids. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). Indicus|evm.model.CM009507.1.564 O00541 PESC_HUMAN 77.508 0.993162 0.994898 PES1 - Pescadillo homolog - Homo sapiens (Human) - PES1 gene Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Indicus|evm.model.CM009507.1.565 Q9XSC9 TCO2_BOVIN 99.306 0.995381 1.00231 TCN2 - Transcobalamin-2 precursor - Bos taurus (Bovine) - TCN2 gene Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Indicus|evm.model.CM009507.1.566 Q6ICL7 S35E4_HUMAN 88.571 0.994302 1.00286 SLC35E4 - Solute carrier family 35 member E4 - Homo sapiens (Human) - SLC35E4 gene Putative transporter. Indicus|evm.model.CM009507.1.567 Q5BIP9 DUS18_BOVIN 100.000 0.989418 1.00532 DUSP18 - Dual specificity protein phosphatase 18 - Bos taurus (Bovine) - DUSP18 gene Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). Indicus|evm.model.CM009507.1.568 A6NGY3 CE052_HUMAN 63.333 0.764103 1.22642 C5orf52 - Uncharacterized protein C5orf52 - Homo sapiens (Human) - C5orf52 gene Indicus|evm.model.CM009507.1.569 Q3B7Z2 OSBP1_MOUSE 72.165 0.310458 0.380124 Osbp - Oxysterol-binding protein 1 - Mus musculus (Mouse) - Osbp gene Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. Indicus|evm.model.CM009507.1.570 Q969R2 OSBP2_HUMAN 87.046 0.993661 0.688865 OSBP2 - Oxysterol-binding protein 2 - Homo sapiens (Human) - OSBP2 gene Binds 7-ketocholesterol. Indicus|evm.model.CM009507.1.571 Q9Y6X9 MORC2_HUMAN 92.219 0.998077 1.00775 MORC2 - ATPase MORC2 - Homo sapiens (Human) - MORC2 gene Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20225202, PubMed:20110259). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). Indicus|evm.model.CM009507.1.572 P53814 SMTN_HUMAN 85.948 0.997795 0.989095 SMTN - Smoothelin - Homo sapiens (Human) - SMTN gene Structural protein of the cytoskeleton. Indicus|evm.model.CM009507.1.573 Q8WWX9 SELM_HUMAN 74.790 0.80916 0.903448 SELENOM - Selenoprotein M precursor - Homo sapiens (Human) - SELENOM gene May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation. Indicus|evm.model.CM009507.1.574 Q15735 PI5PA_HUMAN 93.409 0.497186 1.05964 INPP5J - Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A - Homo sapiens (Human) - INPP5J gene Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity). Indicus|evm.model.CM009507.1.575 Q1JPB9 PA2G3_BOVIN 79.592 0.945841 1.03194 PLA2G3 - Group 3 secretory phospholipase A2 precursor - Bos taurus (Bovine) - PLA2G3 gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids without apparent head group selectivity (By similarity). Contributes to phospholipid remodeling of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (By similarity). May act in an autocrine and paracrine manner. Secreted by immature mast cells, acts on nearby fibroblasts upstream to PTDGS to synthesize prostaglandin D2 (PGD2), which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). Secreted by epididymal epithelium, acts on immature sperm cells within the duct, modulating the degree of unsaturation of the fatty acyl components of phosphatidylcholines required for acrosome assembly and sperm cell motility. Facilitates the replacement of fatty acyl chains in phosphatidylcholines in sperm membranes from omega-6 and omega-9 to omega-3 polyunsaturated fatty acids (PUFAs). Coupled to lipoxygenase pathway, may process omega-6 PUFAs to generate oxygenated lipid mediators in the male reproductive tract (By similarity). At pericentrosomal preciliary compartment, negatively regulates ciliogenesis likely by regulating endocytotic recycling of ciliary membrane protein (By similarity). Coupled to cyclooxygenase pathway provides arachidonate to generate prostaglandin E2 (PGE2), a potent immunomodulatory lipid in inflammation and tumorigenesis (By similarity). At colonic epithelial barrier, preferentially hydrolyzes phospholipids having arachidonate and docosahexaenoate at sn-2 position, contributing to the generation of oxygenated metabolites involved in colonic stem cell homeostasis (By similarity). Releases C16:0 and C18:0 lysophosphatidylcholine subclasses from neuron plasma membranes and promotes neurite outgrowth and neuron survival (By similarity). Indicus|evm.model.CM009507.1.576 Q96GF1 RN185_HUMAN 98.438 0.989637 1.00521 RNF185 - E3 ubiquitin-protein ligase RNF185 - Homo sapiens (Human) - RNF185 gene E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036). Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521). Indicus|evm.model.CM009507.1.577 Q32L23 LIMK2_BOVIN 99.843 0.99687 1.00157 LIMK2 - LIM domain kinase 2 - Bos taurus (Bovine) - LIMK2 gene Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity). Indicus|evm.model.CM009507.1.578 Q1RMT9 P3IP1_BOVIN 100.000 0.973783 1.02299 PIK3IP1 - Phosphoinositide-3-kinase-interacting protein 1 precursor - Bos taurus (Bovine) - PIK3IP1 gene Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity. Indicus|evm.model.CM009507.1.579 Q9HBE1 PATZ1_HUMAN 92.576 0.996885 0.934498 PATZ1 - POZ-, AT hook-, and zinc finger-containing protein 1 - Homo sapiens (Human) - PATZ1 gene Transcriptional repressor. Indicus|evm.model.CM009507.1.580 Q9Y295 DRG1_HUMAN 100.000 0.994565 1.00272 DRG1 - Developmentally-regulated GTP-binding protein 1 - Homo sapiens (Human) - DRG1 gene Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). Indicus|evm.model.CM009507.1.581 Q9NRA8 4ET_HUMAN 95.533 0.99797 1 EIF4ENIF1 - Eukaryotic translation initiation factor 4E transporter - Homo sapiens (Human) - EIF4ENIF1 gene EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). Indicus|evm.model.CM009507.1.582 A8K8P3 SFI1_HUMAN 64.313 0.998441 1.03301 SFI1 - Protein SFI1 homolog - Homo sapiens (Human) - SFI1 gene Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2. Indicus|evm.model.CM009507.1.583 Q58DH2 PISD_BOVIN 100.000 0.735941 0.983173 PISD - Phosphatidylserine decarboxylase proenzyme, mitochondrial precursor - Bos taurus (Bovine) - PISD gene Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Indicus|evm.model.CM009507.1.584 Q5THK1 PR14L_HUMAN 60.028 0.999057 0.986518 PRR14L - Protein PRR14L - Homo sapiens (Human) - PRR14L gene Indicus|evm.model.CM009507.1.585 O75140 DEPD5_HUMAN 94.198 0.998745 0.994386 DEPDC5 - GATOR complex protein DEPDC5 - Homo sapiens (Human) - DEPDC5 gene As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. Indicus|evm.model.CM009507.1.586 P68511 1433F_RAT 99.091 0.99095 0.898374 Ywhah - 14-3-3 protein eta - Rattus norvegicus (Rat) - Ywhah gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). Indicus|evm.model.CM009507.1.587 P53791 SC5A1_SHEEP 94.127 0.99688 0.965361 SLC5A1 - Sodium/glucose cotransporter 1 - Ovis aries (Sheep) - SLC5A1 gene Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Indicus|evm.model.CM009507.1.588 P31636 SC5A4_PIG 92.643 0.997001 1.01061 SLC5A4 - Solute carrier family 5 member 4 - Sus scrofa (Pig) - SLC5A4 gene Has electrogenic activity in response to glucose, and may function as a glucose sensor (PubMed:8077195). Also has low-affinity sodium/glucose cotransporter activity; sugar transport activity is tightly coupled to ion transport at neutral pH but is reduced under more acidic conditions (PubMed:8077195, PubMed:13130073). Indicus|evm.model.CM009507.1.589 A0A075B6I7 LV548_HUMAN 79.048 0.350168 2.82857 IGLV5-48 - Probable non-functional immunoglobulin lambda variable 5-48 precursor - Homo sapiens (Human) - IGLV5-48 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Indicus|evm.model.CM009507.1.590 P01703 LV140_HUMAN 74.359 0.338192 2.90678 IGLV1-40 - Immunoglobulin lambda variable 1-40 precursor - Homo sapiens (Human) - IGLV1-40 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.591 A0A075B6I0 LV861_HUMAN 76.923 0.905512 1.04098 IGLV8-61 - Immunoglobulin lambda variable 8-61 precursor - Homo sapiens (Human) - IGLV8-61 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.592 P01706 LV211_HUMAN 70.408 0.208155 3.91597 IGLV2-11 - Immunoglobulin lambda variable 2-11 precursor - Homo sapiens (Human) - IGLV2-11 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.593 A0A075B6I0 LV861_HUMAN 78.218 0.535135 1.51639 IGLV8-61 - Immunoglobulin lambda variable 8-61 precursor - Homo sapiens (Human) - IGLV8-61 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.594 A0A0B4J1Y8 LV949_HUMAN 62.037 0.563536 1.47154 IGLV9-49 - Immunoglobulin lambda variable 9-49 precursor - Homo sapiens (Human) - IGLV9-49 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.595 A0A075B6I0 LV861_HUMAN 76.087 0.411215 0.877049 IGLV8-61 - Immunoglobulin lambda variable 8-61 precursor - Homo sapiens (Human) - IGLV8-61 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.596 P01703 LV140_HUMAN 69.565 0.726115 1.33051 IGLV1-40 - Immunoglobulin lambda variable 1-40 precursor - Homo sapiens (Human) - IGLV1-40 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.598 P01703 LV140_HUMAN 73.636 0.477876 1.91525 IGLV1-40 - Immunoglobulin lambda variable 1-40 precursor - Homo sapiens (Human) - IGLV1-40 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.599 Q86YH2 Z280B_HUMAN 78.077 0.945055 1.00552 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Indicus|evm.model.CM009507.1.600 P78395 PRAME_HUMAN 51.304 0.885312 0.976424 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Indicus|evm.model.CM009507.1.601 P01706 LV211_HUMAN 77.778 0.727891 1.23529 IGLV2-11 - Immunoglobulin lambda variable 2-11 precursor - Homo sapiens (Human) - IGLV2-11 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.602 P0DOY3 IGLC3_HUMAN 85.000 0.0397959 9.24528 IGLC3 - Immunoglobulin lambda constant 3 - Homo sapiens (Human) - IGLC3 gene Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.604 Q9UC06 ZNF70_HUMAN 78.125 0.984581 1.01794 ZNF70 - Zinc finger protein 70 - Homo sapiens (Human) - ZNF70 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009507.1.605 Q9UKI3 VPRE3_HUMAN 70.339 0.959016 0.99187 VPREB3 - Pre-B lymphocyte protein 3 precursor - Homo sapiens (Human) - VPREB3 gene Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. Indicus|evm.model.CM009507.1.606 Q8WYQ4 CV015_HUMAN 61.111 0.642424 1.11486 C22orf15 - Uncharacterized protein C22orf15 - Homo sapiens (Human) - C22orf15 gene Indicus|evm.model.CM009507.1.607 Q8WYQ3 CHC10_HUMAN 92.857 0.979798 0.697183 CHCHD10 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial precursor - Homo sapiens (Human) - CHCHD10 gene May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. Indicus|evm.model.CM009507.1.608 P24347 MMP11_HUMAN 85.809 0.935551 0.985656 MMP11 - Stromelysin-3 precursor - Homo sapiens (Human) - MMP11 gene May play an important role in the progression of epithelial malignancies. Indicus|evm.model.CM009507.1.609 Q5BIN2 SNF5_BOVIN 100.000 0.994819 1.0026 SMARCB1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 - Bos taurus (Bovine) - SMARCB1 gene Core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Indicus|evm.model.CM009507.1.610 Q0P5E4 DERL3_BOVIN 99.134 0.991379 1.00433 DERL3 - Derlin-3 - Bos taurus (Bovine) - DERL3 gene Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins. May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Indicus|evm.model.CM009507.1.611 Q9BYW1 GTR11_HUMAN 83.197 0.925856 1.06048 SLC2A11 - Solute carrier family 2, facilitated glucose transporter member 11 - Homo sapiens (Human) - SLC2A11 gene Facilitative glucose transporter. Indicus|evm.model.CM009507.1.612 Q1ZZU7 MIF_SHEEP 96.875 0.753968 1.09565 MIF - Macrophage migration inhibitory factor - Ovis aries (Sheep) - MIF gene Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity). Indicus|evm.model.CM009507.1.613 P0CG29 GST2_HUMAN 43.575 0.541806 1.22541 GSTT2 - Glutathione S-transferase theta-2 - Homo sapiens (Human) - GSTT2 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity. Indicus|evm.model.CM009507.1.614 Q9D4P7 GSTT4_MOUSE 85.477 0.991736 1.00833 Gstt4 - Glutathione S-transferase theta-4 - Mus musculus (Mouse) - Gstt4 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Indicus|evm.model.CM009507.1.615 Q2NL00 GSTT1_BOVIN 99.167 0.991701 1.00417 GSTT1 - Glutathione S-transferase theta-1 - Bos taurus (Bovine) - GSTT1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity. Indicus|evm.model.CM009507.1.616 Q99L20 GSTT3_MOUSE 79.583 0.843972 1.17012 Gstt3 - Glutathione S-transferase theta-3 - Mus musculus (Mouse) - Gstt3 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows high activity towards 4-nitrobenzyl chloride (4-NBC). Also has lower activity towards 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP), cumene hydroperoxide, 1-chloro-2,4-dinitrobenzene (CDNB), 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl), and ethacrynic acid. Indicus|evm.model.CM009507.1.617 A5PK65 DOPD_BOVIN 84.348 0.0501761 19.2542 DDT - D-dopachrome decarboxylase - Bos taurus (Bovine) - DDT gene Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Indicus|evm.model.CM009507.1.618 Q9UGT4 SUSD2_HUMAN 77.737 0.997567 1 SUSD2 - Sushi domain-containing protein 2 precursor - Homo sapiens (Human) - SUSD2 gene May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994). Indicus|evm.model.CM009507.1.619 P36269 GGT5_HUMAN 79.010 0.996497 0.974403 GGT5 - Glutathione hydrolase 5 proenzyme precursor - Homo sapiens (Human) - GGT5 gene Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318). Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318). May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318). Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656). Indicus|evm.model.CM009507.1.620 P20735 GGT1_PIG 88.192 0.592552 1.60739 GGT1 - Glutathione hydrolase 1 proenzyme precursor - Sus scrofa (Pig) - GGT1 gene Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates and other gamma-glutamyl compounds, such as leukotriene C4 (LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4. Indicus|evm.model.CM009507.1.621 P62323 SMD3_XENLA 100.000 0.984252 1.00794 snrpd3 - Small nuclear ribonucleoprotein Sm D3 - Xenopus laevis (African clawed frog) - snrpd3 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). Indicus|evm.model.CM009507.1.622 Q8BZI6 GUCD1_MOUSE 90.871 0.991736 1.01255 Gucd1 - Protein GUCD1 - Mus musculus (Mouse) - Gucd1 gene Indicus|evm.model.CM009507.1.624 Q9UBR1 BUP1_HUMAN 86.719 0.994805 1.0026 UPB1 - Beta-ureidopropionase - Homo sapiens (Human) - UPB1 gene Catalyzes a late step in pyrimidine degradation (PubMed:22525402, PubMed:24526388). Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide (PubMed:10542323, PubMed:11508704, PubMed:10415095, PubMed:29976570, PubMed:22525402, PubMed:24526388). Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable). Indicus|evm.model.CM009507.1.625 Q6TLI7 AA2AR_HORSE 87.234 0.34985 1.6165 ADORA2A - Adenosine receptor A2a - Equus caballus (Horse) - ADORA2A gene Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Indicus|evm.model.CM009507.1.626 Q69YQ0 CYTSA_HUMAN 93.029 0.998214 1.00269 SPECC1L - Cytospin-A - Homo sapiens (Human) - SPECC1L gene Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. Indicus|evm.model.CM009507.1.627 P11274 BCR_HUMAN 92.374 0.763482 0.831629 BCR - Breakpoint cluster region protein - Homo sapiens (Human) - BCR gene Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). Indicus|evm.model.CM009507.1.628 F1LXF1 BCR_RAT 95.775 0.5 0.131827 Bcr - Breakpoint cluster region protein - Rattus norvegicus (Rat) - Bcr gene Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity. Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (By similarity). Indicus|evm.model.CM009507.1.630 O95755 RAB36_HUMAN 87.266 0.992537 0.804805 RAB36 - Ras-related protein Rab-36 - Homo sapiens (Human) - RAB36 gene Protein transport. Probably involved in vesicular traffic (By similarity). Indicus|evm.model.CM009507.1.632 Q9D3W1 RSP14_MOUSE 72.667 0.908537 0.480938 Rsph14 - Radial spoke head 14 homolog - Mus musculus (Mouse) - Rsph14 gene Indicus|evm.model.CM009507.1.633 P19627 GNAZ_RAT 96.207 0.960133 0.847887 Gnaz - Guanine nucleotide-binding protein G(z) subunit alpha - Rattus norvegicus (Rat) - Gnaz gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Indicus|evm.model.CM009507.1.634 Q9D3W1 RSP14_MOUSE 70.936 0.736264 0.800587 Rsph14 - Radial spoke head 14 homolog - Mus musculus (Mouse) - Rsph14 gene Indicus|evm.model.CM009507.1.635 P53791 SC5A1_SHEEP 56.079 0.968843 1.01506 SLC5A1 - Sodium/glucose cotransporter 1 - Ovis aries (Sheep) - SLC5A1 gene Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Indicus|evm.model.CM009507.1.636 P0CG04 IGLC1_HUMAN 70.476 0.492891 1.99057 IGLC1 - Immunoglobulin lambda constant 1 - Homo sapiens (Human) - IGLC1 gene Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.637 O95985 TOP3B_HUMAN 91.250 0.897727 0.204176 TOP3B - DNA topoisomerase 3-beta-1 - Homo sapiens (Human) - TOP3B gene Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity. Indicus|evm.model.CM009507.1.638 P12018 VPREB_HUMAN 70.339 0.764706 1.05517 VPREB1 - Immunoglobulin iota chain precursor - Homo sapiens (Human) - VPREB1 gene Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation. Indicus|evm.model.CM009507.1.639 O95985 TOP3B_HUMAN 93.908 0.573868 1.35847 TOP3B - DNA topoisomerase 3-beta-1 - Homo sapiens (Human) - TOP3B gene Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity. Indicus|evm.model.CM009507.1.640 P46196 MK01_BOVIN 95.575 0.768879 1.21389 MAPK1 - Mitogen-activated protein kinase 1 - Bos taurus (Bovine) - MAPK1 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint (By similarity). Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2. Indicus|evm.model.CM009507.1.644 Q14129 DGCR6_HUMAN 87.417 0.842697 0.809091 DGCR6 - Protein DGCR6 - Homo sapiens (Human) - DGCR6 gene May play a role in neural crest cell migration into the third and fourth pharyngeal pouches. Indicus|evm.model.CM009507.1.645 O60688 YPEL1_HUMAN 99.160 0.791946 1.2521 YPEL1 - Protein yippee-like 1 - Homo sapiens (Human) - YPEL1 gene May play a role in epithelioid conversion of fibroblasts. Indicus|evm.model.CM009507.1.646 Q13356 PPIL2_HUMAN 90.805 0.996176 1.00577 PPIL2 - RING-type E3 ubiquitin-protein ligase PPIL2 - Homo sapiens (Human) - PPIL2 gene Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). Indicus|evm.model.CM009507.1.648 Q3T083 SDF2L_BOVIN 99.548 0.990991 1.00452 SDF2L1 - Stromal cell-derived factor 2-like protein 1 precursor - Bos taurus (Bovine) - SDF2L1 gene Indicus|evm.model.CM009507.1.649 Q95LR6 CC116_MACFA 63.196 0.60597 1.26894 CCDC116 - Coiled-coil domain-containing protein 116 - Macaca fascicularis (Crab-eating macaque) - CCDC116 gene centrosome Indicus|evm.model.CM009507.1.650 Q14BV6 YDJC_MOUSE 85.342 0.944444 1.04516 Ydjc - Carbohydrate deacetylase - Mus musculus (Mouse) - Ydjc gene Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. Indicus|evm.model.CM009507.1.651 P68037 UB2L3_MOUSE 100.000 0.985401 0.88961 Ube2l3 - Ubiquitin-conjugating enzyme E2 L3 - Mus musculus (Mouse) - Ube2l3 gene Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. Indicus|evm.model.CM009507.1.652 Q80U40 RIMB2_MOUSE 60.563 0.0435323 1.5 Rimbp2 - RIMS-binding protein 2 - Mus musculus (Mouse) - Rimbp2 gene Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. Indicus|evm.model.CM009507.1.653 Q96JB3 HIC2_HUMAN 82.267 0.945804 0.930081 HIC2 - Hypermethylated in cancer 2 protein - Homo sapiens (Human) - HIC2 gene Transcriptional repressor. Indicus|evm.model.CM009507.1.654 Q9JJB1 T191C_MOUSE 68.690 0.993311 0.990066 Tmem191c - Transmembrane protein 191C - Mus musculus (Mouse) - Tmem191c gene Indicus|evm.model.CM009507.1.655 O02811 PI4KA_BOVIN 99.951 0.984623 0.99001 PI4KA - Phosphatidylinositol 4-kinase alpha - Bos taurus (Bovine) - PI4KA gene Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. Indicus|evm.model.CM009507.1.656 Q0II86 SNP29_BOVIN 100.000 0.803175 1.22093 SNAP29 - Synaptosomal-associated protein 29 - Bos taurus (Bovine) - SNAP29 gene SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. Indicus|evm.model.CM009507.1.657 P46109 CRKL_HUMAN 75.578 0.992032 0.828383 CRKL - Crk-like protein - Homo sapiens (Human) - CRKL gene May mediate the transduction of intracellular signals. Indicus|evm.model.CM009507.1.659 Q96NN9 AIFM3_HUMAN 93.388 0.996661 0.990083 AIFM3 - Apoptosis-inducing factor 3 - Homo sapiens (Human) - AIFM3 gene Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. Indicus|evm.model.CM009507.1.660 Q8N653 LZTR1_HUMAN 93.333 0.510078 0.767857 LZTR1 - Leucine-zipper-like transcriptional regulator 1 - Homo sapiens (Human) - LZTR1 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304). Indicus|evm.model.CM009507.1.661 Q9BT49 THAP7_HUMAN 72.168 0.992218 0.831715 THAP7 - THAP domain-containing protein 7 - Homo sapiens (Human) - THAP7 gene Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors. Indicus|evm.model.CM009507.1.662 Q68FR8 TBA3_RAT 100.000 0.995565 1.00222 Tuba3a - Tubulin alpha-3 chain - Rattus norvegicus (Rat) - Tuba3a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009507.1.663 Q6ZQY2 LR74B_HUMAN 79.319 0.984496 0.987245 LRRC74B - Leucine-rich repeat-containing protein 74B - Homo sapiens (Human) - LRRC74B gene Indicus|evm.model.CM009507.1.664 O15547 P2RX6_HUMAN 83.607 0.883777 0.936508 P2RX6 - P2X purinoceptor 6 - Homo sapiens (Human) - P2RX6 gene Receptor for ATP that acts as a ligand-gated ion channel. Indicus|evm.model.CM009507.1.665 O43246 CTR4_HUMAN 74.525 0.993651 0.992126 SLC7A4 - Cationic amino acid transporter 4 - Homo sapiens (Human) - SLC7A4 gene Involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Indicus|evm.model.CM009507.1.666 Q68FR8 TBA3_RAT 100.000 0.955224 1.04222 Tuba3a - Tubulin alpha-3 chain - Rattus norvegicus (Rat) - Tuba3a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009507.1.667 A5PJV8 MZT2_BOVIN 100.000 0.983607 0.772152 MZT2 - Mitotic-spindle organizing protein 2 - Bos taurus (Bovine) - MZT2 gene centrosome, gamma-tubulin ring complex, spindle Indicus|evm.model.CM009507.1.668 Q9NXE4 NSMA3_HUMAN 87.544 0.991755 0.98037 SMPD4 - Sphingomyelin phosphodiesterase 4 - Homo sapiens (Human) - SMPD4 gene Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function (PubMed:31495489). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924). In skeletal muscle, mediates TNF-stimulated oxidant production (By similarity). Indicus|evm.model.CM009507.1.669 Q96LY2 CC74B_HUMAN 46.569 0.99373 0.839474 CCDC74B - Coiled-coil domain-containing protein 74B - Homo sapiens (Human) - CCDC74B gene Indicus|evm.model.CM009507.1.670 Q6NS15 MED15_XENLA 84.932 0.511236 0.916345 med15 - Mediator of RNA polymerase II transcription subunit 15 - Xenopus laevis (African clawed frog) - med15 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation (By similarity). Positively regulates the Nodal signaling pathway. Indicus|evm.model.CM009507.1.671 Q53GT1 KLH22_HUMAN 94.164 0.99685 1.00158 KLHL22 - Kelch-like protein 22 - Homo sapiens (Human) - KLHL22 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (PubMed:19995937, PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy (PubMed:29769719). Indicus|evm.model.CM009507.1.673 Q96GP6 SREC2_HUMAN 94.912 0.971154 0.597015 SCARF2 - Scavenger receptor class F member 2 precursor - Homo sapiens (Human) - SCARF2 gene Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity). Indicus|evm.model.CM009507.1.674 Q96GP6 SREC2_HUMAN 81.579 0.961538 0.0895522 SCARF2 - Scavenger receptor class F member 2 precursor - Homo sapiens (Human) - SCARF2 gene Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity). Indicus|evm.model.CM009507.1.675 Q16587 ZNF74_HUMAN 77.188 0.594937 0.981366 ZNF74 - Zinc finger protein 74 - Homo sapiens (Human) - ZNF74 gene May play a role in RNA metabolism. Indicus|evm.model.CM009507.1.676 P98153 IDD_HUMAN 82.443 0.894831 1.02 DGCR2 - Integral membrane protein DGCR2/IDD precursor - Homo sapiens (Human) - DGCR2 gene Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration. Indicus|evm.model.CM009507.1.677 Q3SZW1 TSSK1_BOVIN 99.728 0.994565 1.00272 TSSK1B - Testis-specific serine/threonine-protein kinase 1 - Bos taurus (Bovine) - TSSK1B gene Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body (By similarity). Indicus|evm.model.CM009507.1.678 O54863 TSSK2_MOUSE 94.693 0.994429 1.00279 Tssk2 - Testis-specific serine/threonine-protein kinase 2 - Mus musculus (Mouse) - Tssk2 gene Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-281' of TSKS and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. Indicus|evm.model.CM009507.1.679 Q96DF8 ESS2_HUMAN 89.958 0.995825 1.0063 ESS2 - Splicing factor ESS-2 homolog - Homo sapiens (Human) - ESS2 gene May be involved in pre-mRNA splicing. Indicus|evm.model.CM009507.1.680 P79110 TXTP_BOVIN 98.208 0.557114 1.6045 SLC25A1 - Tricarboxylate transport protein, mitochondrial precursor - Bos taurus (Bovine) - SLC25A1 gene Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Indicus|evm.model.CM009507.1.681 P54198 HIRA_HUMAN 90.297 0.914623 1.0826 HIRA - Protein HIRA - Homo sapiens (Human) - HIRA gene Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Indicus|evm.model.CM009507.1.682 Q9NQ50 RM40_HUMAN 74.359 0.869955 1.08252 MRPL40 - 39S ribosomal protein L40, mitochondrial precursor - Homo sapiens (Human) - MRPL40 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, nucleolus, nucleus, RNA binding, anatomical structure morphogenesis, mitochondrial translational elongation, mitochondrial translational termination Indicus|evm.model.CM009507.1.683 Q3SZ70 CV039_BOVIN 100.000 0.236842 2.55769 UPF0545 protein C22orf39 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009507.1.684 Q92890 UFD1_HUMAN 97.720 0.993506 1.00326 UFD1 - Ubiquitin recognition factor in ER-associated degradation protein 1 - Homo sapiens (Human) - UFD1 gene Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). Indicus|evm.model.CM009507.1.685 O75419 CDC45_HUMAN 90.829 0.996473 1.00177 CDC45 - Cell division control protein 45 homolog - Homo sapiens (Human) - CDC45 gene Required for initiation of chromosomal DNA replication. Indicus|evm.model.CM009507.1.686 Q2HJ22 CLD5_BOVIN 100.000 0.653614 1.52294 CLDN5 - Claudin-5 - Bos taurus (Bovine) - CLDN5 gene Plays a major role in tight junction-specific obliteration of the intercellular space. Indicus|evm.model.CM009507.1.689 Q0VC68 SEPT5_BOVIN 99.716 0.926121 1.0271 SEPTIN5 - Septin-5 - Bos taurus (Bovine) - SEPTIN5 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). Indicus|evm.model.CM009507.1.690 O43435 TBX1_HUMAN 98.095 0.137384 1.90201 TBX1 - T-box transcription factor TBX1 - Homo sapiens (Human) - TBX1 gene Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity). Indicus|evm.model.CM009507.1.692 Q9N2I8 TRXR2_BOVIN 92.798 0.991228 0.892368 TXNRD2 - Thioredoxin reductase 2, mitochondrial precursor - Bos taurus (Bovine) - TXNRD2 gene Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. Indicus|evm.model.CM009507.1.693 A7MBI7 COMT_BOVIN 98.980 0.850877 0.419118 COMT - Catechol O-methyltransferase - Bos taurus (Bovine) - COMT gene Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Indicus|evm.model.CM009507.1.695 O00192 ARVC_HUMAN 90.185 0.558115 0.992723 ARVCF - Armadillo repeat protein deleted in velo-cardio-facial syndrome - Homo sapiens (Human) - ARVCF gene Involved in protein-protein interactions at adherens junctions. Indicus|evm.model.CM009507.1.696 Q29RZ5 TNG2_BOVIN 100.000 0.620833 0.869565 TANGO2 - Transport and Golgi organization protein 2 homolog - Bos taurus (Bovine) - TANGO2 gene Golgi apparatus, Golgi organization, protein secretion Indicus|evm.model.CM009507.1.697 Q29RZ5 TNG2_BOVIN 96.970 0.942446 0.503623 TANGO2 - Transport and Golgi organization protein 2 homolog - Bos taurus (Bovine) - TANGO2 gene Golgi apparatus, Golgi organization, protein secretion Indicus|evm.model.CM009507.1.698 A6QR44 DGCR8_BOVIN 94.757 0.997506 1.05526 DGCR8 - Microprocessor complex subunit DGCR8 - Bos taurus (Bovine) - DGCR8 gene Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (By similarity). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Indicus|evm.model.CM009507.1.699 Q8IZ69 TRM2A_HUMAN 78.956 0.932007 0.9648 TRMT2A - tRNA (uracil-5-)-methyltransferase homolog A - Homo sapiens (Human) - TRMT2A gene May be involved in nucleic acid metabolism and/or modifications. Indicus|evm.model.CM009507.1.700 Q3T0M7 RANG_BOVIN 97.059 0.776923 0.631068 RANBP1 - Ran-specific GTPase-activating protein - Bos taurus (Bovine) - RANBP1 gene Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity). Indicus|evm.model.CM009507.1.701 Q3T0M7 RANG_BOVIN 99.029 0.927273 0.533981 RANBP1 - Ran-specific GTPase-activating protein - Bos taurus (Bovine) - RANBP1 gene Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity). Indicus|evm.model.CM009507.1.702 Q9ULC8 ZDHC8_HUMAN 100.000 0.049635 0.895425 ZDHHC8 - Palmitoyltransferase ZDHHC8 - Homo sapiens (Human) - ZDHHC8 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). Indicus|evm.model.CM009507.1.703 H7C350 CC188_HUMAN 68.458 0.85743 1.23881 CCDC188 - Coiled-coil domain-containing protein 188 - Homo sapiens (Human) - CCDC188 gene Indicus|evm.model.CM009507.1.705 Q9N0E3 RTN4R_MACFA 87.738 0.995781 1.00211 RTN4R - Reticulon-4 receptor precursor - Macaca fascicularis (Crab-eating macaque) - RTN4R gene Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (By similarity). Interacts with OMG (By similarity). Indicus|evm.model.CM009507.1.706 P01703 LV140_HUMAN 76.522 0.797203 1.21186 IGLV1-40 - Immunoglobulin lambda variable 1-40 precursor - Homo sapiens (Human) - IGLV1-40 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Indicus|evm.model.CM009507.1.707 Q9BXQ6 T121B_HUMAN 79.821 0.990741 0.373702 TMEM121B - Transmembrane protein 121B - Homo sapiens (Human) - TMEM121B gene Indicus|evm.model.CM009508.1.1 Q8IYA2 C144C_HUMAN 55.000 0.477966 0.47696 CCDC144CP - Putative coiled-coil domain-containing protein 144C - Homo sapiens (Human) - CCDC144CP gene Indicus|evm.model.CM009508.1.2 A6H7B5 CSN3_BOVIN 55.645 0.979167 0.22695 COPS3 - COP9 signalosome complex subunit 3 - Bos taurus (Bovine) - COPS3 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (By similarity). Indicus|evm.model.CM009508.1.4 P13272 UCRI_BOVIN 100.000 0.992727 1.00365 UQCRFS1 - Cytochrome b-c1 complex subunit Rieske, mitochondrial precursor - Bos taurus (Bovine) - UQCRFS1 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity). Indicus|evm.model.CM009508.1.5 A6NLU5 VTM2B_HUMAN 93.919 0.370277 1.39298 VSTM2B - V-set and transmembrane domain-containing protein 2B precursor - Homo sapiens (Human) - VSTM2B gene integral component of membrane Indicus|evm.model.CM009508.1.7 A2VE70 VAC14_BOVIN 100.000 0.36616 1.93231 VAC14 - Protein VAC14 homolog - Bos taurus (Bovine) - VAC14 gene The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (By similarity). Indicus|evm.model.CM009508.1.8 A6QL48 IL34_BOVIN 100.000 0.991489 1.00427 IL34 - Interleukin-34 precursor - Bos taurus (Bovine) - IL34 gene Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity). Indicus|evm.model.CM009508.1.9 Q64LC9 RBM4B_RAT 58.140 0.950739 0.568627 Rbm4b - RNA-binding protein 4B - Rattus norvegicus (Rat) - Rbm4b gene Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity). Indicus|evm.model.CM009508.1.10 Q15393 SF3B3_HUMAN 100.000 0.998358 1.00082 SF3B3 - Splicing factor 3B subunit 3 - Homo sapiens (Human) - SF3B3 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). Indicus|evm.model.CM009508.1.11 Q3MHG0 COG4_BOVIN 99.873 0.992405 1.00637 COG4 - Conserved oligomeric Golgi complex subunit 4 - Bos taurus (Bovine) - COG4 gene Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Indicus|evm.model.CM009508.1.12 Q8N0W3 FCSK_HUMAN 87.396 0.998148 0.99631 FCSK - L-fucose kinase - Homo sapiens (Human) - FCSK gene Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides. Indicus|evm.model.CM009508.1.13 Q16842 SIA4B_HUMAN 96.000 0.994302 1.00286 ST3GAL2 - CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 - Homo sapiens (Human) - ST3GAL2 gene A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8920913, PubMed:9266697, PubMed:25916169). Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (PubMed:12716912). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:9266697, PubMed:25916169). Indicus|evm.model.CM009508.1.14 Q3ZBV2 DD19A_BOVIN 100.000 0.995825 1.00209 DDX19A - ATP-dependent RNA helicase DDX19A - Bos taurus (Bovine) - DDX19A gene ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. Indicus|evm.model.CM009508.1.15 Q9UMR2 DD19B_HUMAN 98.121 0.995833 1.00209 DDX19B - ATP-dependent RNA helicase DDX19B - Homo sapiens (Human) - DDX19B gene ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). Indicus|evm.model.CM009508.1.16 P49588 SYAC_HUMAN 95.455 0.997936 1.00103 AARS1 - Alanine--tRNA ligase, cytoplasmic - Homo sapiens (Human) - AARS1 gene Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438). Indicus|evm.model.CM009508.1.17 A5D8T8 CL18A_HUMAN 90.909 0.550193 1.16143 CLEC18A - C-type lectin domain family 18 member A precursor - Homo sapiens (Human) - CLEC18A gene Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455). Indicus|evm.model.CM009508.1.18 Q6UXF7 CL18B_HUMAN 68.939 0.64532 0.446154 CLEC18B - C-type lectin domain family 18 member B precursor - Homo sapiens (Human) - CLEC18B gene Binds polysaccharides in a Ca(2+)-independent manner (By similarity). Indicus|evm.model.CM009508.1.19 O46504 PDPR_BOVIN 99.658 0.997725 1.00114 PDPR - Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial precursor - Bos taurus (Bovine) - PDPR gene Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine. Indicus|evm.model.CM009508.1.20 Q92896 GSLG1_HUMAN 98.318 0.898319 1.00933 GLG1 - Golgi apparatus protein 1 precursor - Homo sapiens (Human) - GLG1 gene Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). Indicus|evm.model.CM009508.1.21 Q7L5A8 FA2H_HUMAN 81.138 0.208516 4.29301 FA2H - Fatty acid 2-hydroxylase - Homo sapiens (Human) - FA2H gene Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15337768, PubMed:15863841, PubMed:17355976, PubMed:22517924). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (PubMed:17355976). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (By similarity). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity). Indicus|evm.model.CM009508.1.22 Q6PJI9 WDR59_HUMAN 97.331 0.997949 1.00103 WDR59 - GATOR complex protein WDR59 - Homo sapiens (Human) - WDR59 gene As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). Indicus|evm.model.CM009508.1.23 F1MM41 ZNRF1_BOVIN 97.357 0.991228 1.00441 ZNRF1 - E3 ubiquitin-protein ligase ZNRF1 - Bos taurus (Bovine) - ZNRF1 gene E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes degeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (By similarity). Indicus|evm.model.CM009508.1.24 Q7TNG8 LDHD_MOUSE 84.504 0.995876 1.00207 Ldhd - Probable D-lactate dehydrogenase, mitochondrial precursor - Mus musculus (Mouse) - Ldhd gene Involved in D-lactate, but not L-lactate catabolic process. Indicus|evm.model.CM009508.1.25 Q6P2D0 ZFP1_HUMAN 91.912 0.99511 1.00491 ZFP1 - Zinc finger protein 1 homolog - Homo sapiens (Human) - ZFP1 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.27 P00767 CTRB_BOVIN 98.367 0.924242 1.07755 Chymotrypsinogen B precursor - Bos taurus (Bovine) Indicus|evm.model.CM009508.1.28 P00766 CTRA_BOVIN 100.000 0.924242 1.07755 Chymotrypsinogen A precursor - Bos taurus (Bovine) Indicus|evm.model.CM009508.1.29 P00767 CTRB_BOVIN 68.571 0.918033 0.995918 Chymotrypsinogen B precursor - Bos taurus (Bovine) Indicus|evm.model.CM009508.1.30 P56945 BCAR1_HUMAN 85.845 0.973472 0.996552 BCAR1 - Breast cancer anti-estrogen resistance protein 1 - Homo sapiens (Human) - BCAR1 gene Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12832404, PubMed:12432078). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). Indicus|evm.model.CM009508.1.31 Q8HXY9 CFDP1_BOVIN 99.663 0.993289 1.00337 CFDP1 - Craniofacial development protein 1 - Bos taurus (Bovine) - CFDP1 gene May play a role during embryogenesis. Indicus|evm.model.CM009508.1.32 O02751 CFDP2_BOVIN 99.493 0.876855 1.13851 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Indicus|evm.model.CM009508.1.33 Q32L59 TMC5B_BOVIN 88.636 0.0677165 1.80912 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Indicus|evm.model.CM009508.1.34 Q8WVE7 T170A_HUMAN 97.917 0.986207 1.00694 TMEM170A - Transmembrane protein 170A - Homo sapiens (Human) - TMEM170A gene Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). Indicus|evm.model.CM009508.1.36 A7MB75 TM231_BOVIN 100.000 0.293725 2.37025 TMEM231 - Transmembrane protein 231 - Bos taurus (Bovine) - TMEM231 gene Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). Indicus|evm.model.CM009508.1.37 P60522 GBRL2_RAT 100.000 0.686391 1.44444 Gabarapl2 - Gamma-aminobutyric acid receptor-associated protein-like 2 precursor - Rattus norvegicus (Rat) - Gabarapl2 gene Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). Indicus|evm.model.CM009508.1.38 Q9BUB4 ADAT1_HUMAN 80.645 0.869318 1.05179 ADAT1 - tRNA-specific adenosine deaminase 1 - Homo sapiens (Human) - ADAT1 gene Specifically deaminates adenosine-37 to inosine in tRNA-Ala. Indicus|evm.model.CM009508.1.39 Q15046 SYK_HUMAN 93.300 0.996644 0.998325 KARS1 - Lysine--tRNA ligase - Homo sapiens (Human) - KARS1 gene Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739). Indicus|evm.model.CM009508.1.40 Q0VCT3 TE2IP_BOVIN 100.000 0.995 1.00251 TERF2IP - Telomeric repeat-binding factor 2-interacting protein 1 - Bos taurus (Bovine) - TERF2IP gene Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity). Indicus|evm.model.CM009508.1.45 Q7L1V2 MON1B_HUMAN 88.525 0.994536 1.00366 MON1B - Vacuolar fusion protein MON1 homolog B - Homo sapiens (Human) - MON1B gene cytoplasm, Mon1-Ccz1 complex, early viral transcription, late viral transcription Indicus|evm.model.CM009508.1.46 Q8N0S2 SYCE1_HUMAN 58.673 0.691756 0.794872 SYCE1 - Synaptonemal complex central element protein 1 - Homo sapiens (Human) - SYCE1 gene Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. Indicus|evm.model.CM009508.1.47 Q8TE60 ATS18_HUMAN 83.791 0.973373 0.830467 ADAMTS18 - A disintegrin and metalloproteinase with thrombospondin motifs 18 precursor - Homo sapiens (Human) - ADAMTS18 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization, eye development, negative regulation of platelet aggregation Indicus|evm.model.CM009508.1.48 Q8TE60 ATS18_HUMAN 90.226 0.589286 0.183456 ADAMTS18 - A disintegrin and metalloproteinase with thrombospondin motifs 18 precursor - Homo sapiens (Human) - ADAMTS18 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization, eye development, negative regulation of platelet aggregation Indicus|evm.model.CM009508.1.49 P0C024 NUDT7_HUMAN 68.067 0.911538 1.09244 NUDT7 - Peroxisomal coenzyme A diphosphatase NUDT7 - Homo sapiens (Human) - NUDT7 gene Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Indicus|evm.model.CM009508.1.50 Q9HCJ6 VAT1L_HUMAN 97.375 0.995238 1.00239 VAT1L - Synaptic vesicle membrane protein VAT-1 homolog-like - Homo sapiens (Human) - VAT1L gene Indicus|evm.model.CM009508.1.51 Q28008 CLC3A_BOVIN 100.000 0.989899 1.00508 CLEC3A - C-type lectin domain family 3 member A precursor - Bos taurus (Bovine) - CLEC3A gene Promotes cell adhesion to laminin and fibronectin. Indicus|evm.model.CM009508.1.53 Q9NZC7 WWOX_HUMAN 95.930 0.994186 0.415459 WWOX - WW domain-containing oxidoreductase - Homo sapiens (Human) - WWOX gene Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. Indicus|evm.model.CM009508.1.56 Q9NZC7 WWOX_HUMAN 93.889 0.937173 0.461353 WWOX - WW domain-containing oxidoreductase - Homo sapiens (Human) - WWOX gene Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. Indicus|evm.model.CM009508.1.61 Q5R9W5 WWOX_PONAB 82.143 0.416667 0.318841 WWOX - WW domain-containing oxidoreductase - Pongo abelii (Sumatran orangutan) - WWOX gene Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). Indicus|evm.model.CM009508.1.66 O75444 MAF_HUMAN 100.000 0.365079 1.0134 MAF - Transcription factor Maf - Homo sapiens (Human) - MAF gene Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Indicus|evm.model.CM009508.1.71 Q32P85 DLRB2_BOVIN 100.000 0.862385 1.13542 DYNLRB2 - Dynein light chain roadblock-type 2 - Bos taurus (Bovine) - DYNLRB2 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Indicus|evm.model.CM009508.1.72 Q8N8U2 CDYL2_HUMAN 86.347 0.81571 1.3083 CDYL2 - Chromodomain Y-like protein 2 - Homo sapiens (Human) - CDYL2 gene nucleus, transcription corepressor activity Indicus|evm.model.CM009508.1.73 Q2NKR3 COXM2_BOVIN 100.000 0.182796 3.53165 CMC2 - COX assembly mitochondrial protein 2 homolog - Bos taurus (Bovine) - CMC2 gene May be involved in cytochrome c oxidase biogenesis. Indicus|evm.model.CM009508.1.74 Q32LL9 CENPN_BOVIN 99.705 0.994118 1.00295 CENPN - Centromere protein N - Bos taurus (Bovine) - CENPN gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. Indicus|evm.model.CM009508.1.75 O43313 ATMIN_HUMAN 83.400 0.984064 0.914945 ATMIN - ATM interactor - Homo sapiens (Human) - ATMIN gene Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. Indicus|evm.model.CM009508.1.76 Q4R912 CP046_MACFA 62.312 0.984887 1.03655 QtsA-10979 - Uncharacterized protein C16orf46 homolog - Macaca fascicularis (Crab-eating macaque) - QtsA-10979 gene Indicus|evm.model.CM009508.1.77 P20821 GCSH_BOVIN 100.000 0.988506 1.00578 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Indicus|evm.model.CM009508.1.78 Q7Z442 PK1L2_HUMAN 74.537 0.990791 0.971533 PKD1L2 - Polycystic kidney disease protein 1-like 2 precursor - Homo sapiens (Human) - PKD1L2 gene May function as an ion-channel regulator. May function as a G-protein-coupled receptor. Indicus|evm.model.CM009508.1.79 Q91XT5 BCDO1_RAT 83.647 0.968978 0.968198 Bco1 - Beta,beta-carotene 15,15'-dioxygenase - Rattus norvegicus (Rat) - Bco1 gene Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. Indicus|evm.model.CM009508.1.80 Q9H2C0 GAN_HUMAN 98.492 0.996656 1.00168 GAN - Gigaxonin - Homo sapiens (Human) - GAN gene Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. Indicus|evm.model.CM009508.1.81 Q8IY22 CMIP_HUMAN 99.257 0.997033 0.871928 CMIP - C-Maf-inducing protein - Homo sapiens (Human) - CMIP gene Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. Indicus|evm.model.CM009508.1.82 P16885 PLCG2_HUMAN 94.075 0.92513 1.0664 PLCG2 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 - Homo sapiens (Human) - PLCG2 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Indicus|evm.model.CM009508.1.83 Q8CIH5 PLCG2_MOUSE 90.476 0.584906 0.0837945 Plcg2 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 - Mus musculus (Mouse) - Plcg2 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Indicus|evm.model.CM009508.1.84 Q32L94 D42E1_BOVIN 100.000 0.994924 1.00254 SDR42E1 - Short-chain dehydrogenase/reductase family 42E member 1 - Bos taurus (Bovine) - SDR42E1 gene oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Indicus|evm.model.CM009508.1.86 P37059 DHB2_HUMAN 65.116 0.992288 1.00517 HSD17B2 - 17-beta-hydroxysteroid dehydrogenase type 2 - Homo sapiens (Human) - HSD17B2 gene Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH. Indicus|evm.model.CM009508.1.87 Q99547 MPH6_HUMAN 93.750 0.987578 1.00625 MPHOSPH6 - M-phase phosphoprotein 6 - Homo sapiens (Human) - MPHOSPH6 gene RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. Indicus|evm.model.CM009508.1.88 Q28FN6 OTX2_XENTR 100.000 0.162921 0.615917 otx2 - Homeobox protein OTX2 - Xenopus tropicalis (Western clawed frog) - otx2 gene May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer gene cer1 by acting synergistically with siamois and mix-A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and ldb1 to the gsc promoter to stimulate expression (By similarity). Indicus|evm.model.CM009508.1.89 Q3B7N0 CAD13_BOVIN 99.627 0.967391 0.387097 CDH13 - Cadherin-13 precursor - Bos taurus (Bovine) - CDH13 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth (By similarity). Indicus|evm.model.CM009508.1.90 O95822 DCMC_HUMAN 84.536 0.71072 1.38134 MLYCD - Malonyl-CoA decarboxylase, mitochondrial precursor - Homo sapiens (Human) - MLYCD gene Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. Indicus|evm.model.CM009508.1.91 Q9UJX0 OSGI1_HUMAN 86.192 0.856373 1.16771 OSGIN1 - Oxidative stress-induced growth inhibitor 1 - Homo sapiens (Human) - OSGIN1 gene Regulates the differentiation and proliferation through the regulation of cell death. Indicus|evm.model.CM009508.1.92 Q7Z6G3 NECA2_HUMAN 87.781 0.782828 1.02591 NECAB2 - N-terminal EF-hand calcium-binding protein 2 - Homo sapiens (Human) - NECAB2 gene May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. Indicus|evm.model.CM009508.1.93 A6NNN8 S38A8_HUMAN 82.759 0.995413 1.0023 SLC38A8 - Putative sodium-coupled neutral amino acid transporter 8 - Homo sapiens (Human) - SLC38A8 gene Putative sodium-dependent amino acid/proton antiporter. Indicus|evm.model.CM009508.1.94 Q14703 MBTP1_HUMAN 95.627 0.998101 1.00095 MBTPS1 - Membrane-bound transcription factor site-1 protease precursor - Homo sapiens (Human) - MBTPS1 gene Serine protease that cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4: known substrates are SREBF1/SREBP1, SREBF2/SREBP2, BDNF, GNPTAB, ATF6 and ATF6B (PubMed:10644685, PubMed:12782636, PubMed:21719679). Cleaves substrates after Arg-Ser-Val-Leu (SREBP2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu (PubMed:10644685, PubMed:21719679). Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12782636). Also mediates the first step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:12782636). Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes (PubMed:21719679). Involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes (PubMed:21719679, PubMed:30046013). It is required for the activation of CREB3L2/BBF2H7, a transcriptional activator of MIA3/TANGO and other genes controlling mega vesicle formation (PubMed:30046013). Therefore, it plays a key role in the regulation of mega vesicle-mediated collagen trafficking (PubMed:30046013). Indicus|evm.model.CM009508.1.95 A5PJF6 HSDL1_BOVIN 100.000 0.993958 1.00303 HSDL1 - Inactive hydroxysteroid dehydrogenase-like protein 1 - Bos taurus (Bovine) - HSDL1 gene mitochondrion Indicus|evm.model.CM009508.1.96 Q3SYS4 DAAF1_BOVIN 100.000 0.19893 1.45412 DNAAF1 - Dynein axonemal assembly factor 1 - Bos taurus (Bovine) - DNAAF1 gene Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity). Indicus|evm.model.CM009508.1.97 Q15572 TAF1C_HUMAN 69.906 0.90604 1.02877 TAF1C - TATA box-binding protein-associated factor RNA polymerase I subunit C - Homo sapiens (Human) - TAF1C gene Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. Indicus|evm.model.CM009508.1.98 Q9D5P4 ADAD2_MOUSE 76.618 0.847518 1.17992 Adad2 - Adenosine deaminase domain-containing protein 2 - Mus musculus (Mouse) - Adad2 gene cytoplasm, nucleolus, double-stranded RNA adenosine deaminase activity, double-stranded RNA binding, tRNA-specific adenosine deaminase activity, adenosine to inosine editing, RNA processing Indicus|evm.model.CM009508.1.99 Q8TDN1 KCNG4_HUMAN 83.398 0.99604 0.973025 KCNG4 - Potassium voltage-gated channel subfamily G member 4 - Homo sapiens (Human) - KCNG4 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135). Indicus|evm.model.CM009508.1.100 O70280 WFDC1_RAT 82.979 0.714286 1.2217 Wfdc1 - WAP four-disulfide core domain protein 1 precursor - Rattus norvegicus (Rat) - Wfdc1 gene Has growth inhibitory activity. Indicus|evm.model.CM009508.1.101 O75185 AT2C2_HUMAN 84.270 0.997959 1.03594 ATP2C2 - Calcium-transporting ATPase type 2C member 2 - Homo sapiens (Human) - ATP2C2 gene ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:15831496, PubMed:16332677, PubMed:30923126, PubMed:15677451). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:15831496, PubMed:16332677). Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus (PubMed:23840669, PubMed:20887894). Indicus|evm.model.CM009508.1.102 Q6P9B6 MEAK7_HUMAN 72.429 0.993464 1.00658 MEAK7 - MTOR-associated protein MEAK7 - Homo sapiens (Human) - MEAK7 gene Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193). Indicus|evm.model.CM009508.1.103 Q2HJ57 COTL1_BOVIN 100.000 0.986014 1.00704 COTL1 - Coactosin-like protein - Bos taurus (Bovine) - COTL1 gene Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity). Indicus|evm.model.CM009508.1.104 Q3B7M1 KLH36_BOVIN 100.000 0.913819 1.09253 KLHL36 - Kelch-like protein 36 - Bos taurus (Bovine) - KLHL36 gene Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009508.1.105 A5PJS6 UBP10_BOVIN 99.875 0.997503 1.00125 USP10 - Ubiquitin carboxyl-terminal hydrolase 10 - Bos taurus (Bovine) - USP10 gene Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Deubiquitinates TBX21 leading to its stabilization. Indicus|evm.model.CM009508.1.106 A6QLZ7 CRLD2_BOVIN 100.000 0.995976 1.00202 CRISPLD2 - Cysteine-rich secretory protein LCCL domain-containing 2 precursor - Bos taurus (Bovine) - CRISPLD2 gene Promotes matrix assembly. Indicus|evm.model.CM009508.1.107 P83917 CBX1_MOUSE 91.406 0.769697 0.891892 Cbx1 - Chromobox protein homolog 1 - Mus musculus (Mouse) - Cbx1 gene Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Indicus|evm.model.CM009508.1.108 Q9NXF8 ZDHC7_HUMAN 93.831 0.993528 1.00325 ZDHHC7 - Palmitoyltransferase ZDHHC7 - Homo sapiens (Human) - ZDHHC7 gene Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095). Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068). In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321). Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity). Indicus|evm.model.CM009508.1.111 O60268 K0513_HUMAN 89.051 0.995134 1 KIAA0513 - Uncharacterized protein KIAA0513 - Homo sapiens (Human) - KIAA0513 gene Indicus|evm.model.CM009508.1.112 Q1RMK1 CBAR2_BOVIN 99.306 0.99308 1.00347 CIBAR2 - CBY1-interacting BAR domain-containing protein 2 - Bos taurus (Bovine) - CIBAR2 gene May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis. Indicus|evm.model.CM009508.1.116 Q14687 GSE1_HUMAN 85.726 0.990123 0.998357 GSE1 - Genetic suppressor element 1 - Homo sapiens (Human) - GSE1 gene Indicus|evm.model.CM009508.1.117 Q9Y248 PSF2_HUMAN 94.595 0.989247 1.00541 GINS2 - DNA replication complex GINS protein PSF2 - Homo sapiens (Human) - GINS2 gene The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. Indicus|evm.model.CM009508.1.118 Q96GX8 CP074_HUMAN 68.675 0.975904 1.09211 C16orf74 - Uncharacterized protein C16orf74 - Homo sapiens (Human) - C16orf74 gene Indicus|evm.model.CM009508.1.119 Q32KL5 EMC8_BOVIN 99.524 0.990521 1.00476 EMC8 - ER membrane protein complex subunit 8 - Bos taurus (Bovine) - EMC8 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Indicus|evm.model.CM009508.1.120 P00423 COX41_BOVIN 100.000 0.988235 1.00592 COX4I1 - Cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor - Bos taurus (Bovine) - COX4I1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009508.1.121 Q02556 IRF8_HUMAN 90.141 0.995316 1.00235 IRF8 - Interferon regulatory factor 8 - Homo sapiens (Human) - IRF8 gene Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:25122610). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed:29434592). Indicus|evm.model.CM009508.1.125 Q12946 FOXF1_HUMAN 96.073 0.994778 1.01055 FOXF1 - Forkhead box protein F1 - Homo sapiens (Human) - FOXF1 gene Probable transcription activator for a number of lung-specific genes. Indicus|evm.model.CM009508.1.126 Q2KI24 MTHSD_BOVIN 92.895 0.994751 1.00263 MTHFSD - Methenyltetrahydrofolate synthase domain-containing protein - Bos taurus (Bovine) - MTHFSD gene cytoplasm Indicus|evm.model.CM009508.1.127 Q99958 FOXC2_HUMAN 95.973 0.590457 1.00399 FOXC2 - Forkhead box protein C2 - Homo sapiens (Human) - FOXC2 gene Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. Indicus|evm.model.CM009508.1.128 Q12952 FOXL1_HUMAN 83.526 0.994236 1.0058 FOXL1 - Forkhead box protein L1 - Homo sapiens (Human) - FOXL1 gene Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity). Indicus|evm.model.CM009508.1.133 Q9H693 CP095_HUMAN 56.338 0.301724 1.46835 C16orf95 - Uncharacterized protein C16orf95 - Homo sapiens (Human) - C16orf95 gene Indicus|evm.model.CM009508.1.134 Q5XUX0 FBX31_HUMAN 82.463 0.974684 0.879406 FBXO31 - F-box only protein 31 - Homo sapiens (Human) - FBXO31 gene Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Indicus|evm.model.CM009508.1.135 O41515 MLP3B_BOVIN 100.000 0.984127 1.008 MAP1LC3B - Microtubule-associated proteins 1A/1B light chain 3B precursor - Bos taurus (Bovine) - MAP1LC3B gene Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Indicus|evm.model.CM009508.1.136 Q8WYQ9 ZCH14_HUMAN 85.535 0.99789 0.998946 ZCCHC14 - Zinc finger CCHC domain-containing protein 14 - Homo sapiens (Human) - ZCCHC14 gene Indicus|evm.model.CM009508.1.139 Q9ET77 JPH3_MOUSE 97.933 0.994845 0.521505 Jph3 - Junctophilin-3 - Mus musculus (Mouse) - Jph3 gene Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory. Indicus|evm.model.CM009508.1.140 Q9ET77 JPH3_MOUSE 83.924 0.899263 0.547043 Jph3 - Junctophilin-3 - Mus musculus (Mouse) - Jph3 gene Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory. Indicus|evm.model.CM009508.1.141 Q5R8W1 KLDC4_PONAB 84.000 0.795302 1.14176 KLHDC4 - Kelch domain-containing protein 4 - Pongo abelii (Sumatran orangutan) - KLHDC4 gene Indicus|evm.model.CM009508.1.142 Q01650 LAT1_HUMAN 91.373 0.996047 0.998028 SLC7A5 - Large neutral amino acids transporter small subunit 1 - Homo sapiens (Human) - SLC7A5 gene The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744). Indicus|evm.model.CM009508.1.143 Q9Y6G9 DC1L1_HUMAN 94.444 0.984252 0.24283 DYNC1LI1 - Cytoplasmic dynein 1 light intermediate chain 1 - Homo sapiens (Human) - DYNC1LI1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Indicus|evm.model.CM009508.1.144 P35218 CAH5A_HUMAN 73.684 0.974277 1.01967 CA5A - Carbonic anhydrase 5A, mitochondrial precursor - Homo sapiens (Human) - CA5A gene Reversible hydration of carbon dioxide. Low activity. Indicus|evm.model.CM009508.1.146 Q0VCW3 BANP_BOVIN 97.550 0.935282 0.952286 BANP - Protein BANP - Bos taurus (Bovine) - BANP gene Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity). Indicus|evm.model.CM009508.1.147 Q0VCW3 BANP_BOVIN 100.000 0.259459 0.367793 BANP - Protein BANP - Bos taurus (Bovine) - BANP gene Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity). Indicus|evm.model.CM009508.1.151 Q96JG9 ZN469_HUMAN 54.593 0.467395 0.863439 ZNF469 - Zinc finger protein 469 - Homo sapiens (Human) - ZNF469 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.153 Q9I9K0 FOG1_XENLA 67.925 0.0754148 0.624882 zfpm1 - Zinc finger protein ZFPM1 - Xenopus laevis (African clawed frog) - zfpm1 gene Transcription regulator that plays an central role in red blood cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1 and GATA2. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Acts as a repressor of red blood cells, probably by modulating activity of GATA1. Indicus|evm.model.CM009508.1.155 Q01717 TRFR_RAT 50.416 0.856061 0.961165 Trhr - Thyrotropin-releasing hormone receptor - Rattus norvegicus (Rat) - Trhr gene Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. Indicus|evm.model.CM009508.1.156 Q86VM9 ZCH18_HUMAN 86.972 0.435897 1.26863 ZC3H18 - Zinc finger CCCH domain-containing protein 18 - Homo sapiens (Human) - ZC3H18 gene nuclear speck, protein-containing complex, ribonucleoprotein complex, mRNA cap binding complex binding, protein-macromolecule adaptor activity, RNA binding, RNA destabilization Indicus|evm.model.CM009508.1.157 O46521 CY24A_BOVIN 100.000 0.989583 1.00524 CYBA - Cytochrome b-245 light chain - Bos taurus (Bovine) - CYBA gene Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Indicus|evm.model.CM009508.1.158 Q0P570 MVD1_BOVIN 99.500 0.995012 1.0025 MVD - Diphosphomevalonate decarboxylase - Bos taurus (Bovine) - MVD gene Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. Indicus|evm.model.CM009508.1.159 O95863 SNAI1_HUMAN 78.571 0.380137 1.10606 SNAI1 - Zinc finger protein SNAI1 - Homo sapiens (Human) - SNAI1 gene Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. Indicus|evm.model.CM009508.1.160 Q96A37 RN166_HUMAN 94.515 0.991597 1.00422 RNF166 - E3 ubiquitin-protein ligase RNF166 - Homo sapiens (Human) - RNF166 gene E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896). In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896). Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228). Plays also a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896). Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896). Indicus|evm.model.CM009508.1.161 Q3SZG9 CTU2_BOVIN 99.800 0.996016 1.002 CTU2 - Cytoplasmic tRNA 2-thiolation protein 2 - Bos taurus (Bovine) - CTU2 gene Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Indicus|evm.model.CM009508.1.162 Q92508 PIEZ1_HUMAN 81.020 0.989483 0.94288 PIEZO1 - Piezo-type mechanosensitive ion channel component 1 - Homo sapiens (Human) - PIEZO1 gene Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation. Indicus|evm.model.CM009508.1.163 Q92508 PIEZ1_HUMAN 73.585 0.820312 0.0507735 PIEZO1 - Piezo-type mechanosensitive ion channel component 1 - Homo sapiens (Human) - PIEZO1 gene Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation. Indicus|evm.model.CM009508.1.164 Q0KL00 PIEZ1_RAT 86.538 0.447368 0.0449704 Piezo1 - Piezo-type mechanosensitive ion channel component 1 - Rattus norvegicus (Rat) - Piezo1 gene Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation. Indicus|evm.model.CM009508.1.165 Q9H211 CDT1_HUMAN 76.492 0.99639 1.01465 CDT1 - DNA replication factor Cdt1 - Homo sapiens (Human) - CDT1 gene Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). Indicus|evm.model.CM009508.1.166 Q56JW4 APT_BOVIN 99.444 0.98895 1.00556 APRT - Adenine phosphoribosyltransferase - Bos taurus (Bovine) - APRT gene Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Indicus|evm.model.CM009508.1.167 Q8WNQ7 GALNS_PIG 91.762 0.996176 1.00192 GALNS - N-acetylgalactosamine-6-sulfatase precursor - Sus scrofa (Pig) - GALNS gene Indicus|evm.model.CM009508.1.168 A6H7F7 TPC2L_BOVIN 100.000 0.900709 1.01439 TRAPPC2L - Trafficking protein particle complex subunit 2-like protein - Bos taurus (Bovine) - TRAPPC2L gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Indicus|evm.model.CM009508.1.169 Q8CCS6 PABP2_MOUSE 69.620 0.343612 0.751656 Pabpn1 - Polyadenylate-binding protein 2 - Mus musculus (Mouse) - Pabpn1 gene Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (By similarity). Indicus|evm.model.CM009508.1.170 O54972 MTG16_MOUSE 88.360 0.977431 0.929032 Cbfa2t3 - Protein CBFA2T3 - Mus musculus (Mouse) - Cbfa2t3 gene Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (By similarity). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:16407974). Plays a role in granulocyte differentiation (PubMed:15231665). Indicus|evm.model.CM009508.1.171 Q58DN7 ACSF3_BOVIN 99.829 0.996593 1.00171 ACSF3 - Malonate--CoA ligase ACSF3, mitochondrial precursor - Bos taurus (Bovine) - ACSF3 gene Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates. Indicus|evm.model.CM009508.1.172 P55291 CAD15_HUMAN 85.878 0.997455 0.965602 CDH15 - Cadherin-15 precursor - Homo sapiens (Human) - CDH15 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. Indicus|evm.model.CM009508.1.173 A6NKX4 S22AV_HUMAN 79.059 0.952809 0.80036 SLC22A31 - Putative solute carrier family 22 member 31 - Homo sapiens (Human) - SLC22A31 gene Organic anion transporter that mediates the uptake of ions. Indicus|evm.model.CM009508.1.175 Q6UB99 ANR11_HUMAN 76.403 0.999231 0.977094 ANKRD11 - Ankyrin repeat domain-containing protein 11 - Homo sapiens (Human) - ANKRD11 gene Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). Indicus|evm.model.CM009508.1.177 Q9UQ90 SPG7_HUMAN 89.544 0.955128 0.981132 SPG7 - Paraplegin precursor - Homo sapiens (Human) - SPG7 gene ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (PubMed:26387735). Indicus|evm.model.CM009508.1.179 Q56JZ1 RL13_BOVIN 100.000 0.990566 1.00474 RPL13 - 60S ribosomal protein L13 - Bos taurus (Bovine) - RPL13 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development. Indicus|evm.model.CM009508.1.180 Q9UBL6 CPNE7_HUMAN 91.183 0.781818 0.868878 CPNE7 - Copine-7 - Homo sapiens (Human) - CPNE7 gene Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Indicus|evm.model.CM009508.1.181 Q3SZM7 DPEP1_BOVIN 99.756 0.855649 1.16585 DPEP1 - Dipeptidase 1 precursor - Bos taurus (Bovine) - DPEP1 gene Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics. Indicus|evm.model.CM009508.1.182 Q5R605 CHM1A_PONAB 97.959 0.989848 1.0051 CHMP1A - Charged multivesicular body protein 1a - Pongo abelii (Sumatran orangutan) - CHMP1A gene Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing (By similarity). Indicus|evm.model.CM009508.1.183 Q8C624 SPT33_MOUSE 47.101 0.985401 1.03788 Spata33 - Spermatogenesis-associated protein 33 - Mus musculus (Mouse) - Spata33 gene cytoplasm, nucleus Indicus|evm.model.CM009508.1.184 Q2TBL8 CDK10_BOVIN 99.723 0.994475 1.00277 CDK10 - Cyclin-dependent kinase 10 - Bos taurus (Bovine) - CDK10 gene Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. Indicus|evm.model.CM009508.1.185 Q0IIA6 SPA2L_BOVIN 100.000 0.995122 1.00244 SPATA2L - Spermatogenesis-associated protein 2-like protein - Bos taurus (Bovine) - SPATA2L gene cytoplasm Indicus|evm.model.CM009508.1.186 Q9Y2B5 VP9D1_HUMAN 80.462 0.99685 1.00634 VPS9D1 - VPS9 domain-containing protein 1 - Homo sapiens (Human) - VPS9D1 gene identical protein binding, transporter activity, ATP synthesis coupled proton transport Indicus|evm.model.CM009508.1.187 Q8N554 ZN276_HUMAN 78.675 0.996689 0.983713 ZNF276 - Zinc finger protein 276 - Homo sapiens (Human) - ZNF276 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.188 O15360 FANCA_HUMAN 66.874 0.992963 0.976632 FANCA - Fanconi anemia group A protein - Homo sapiens (Human) - FANCA gene DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Indicus|evm.model.CM009508.1.189 Q8K1S6 SPIR2_MOUSE 80.000 0.817114 0.830084 Spire2 - Protein spire homolog 2 - Mus musculus (Mouse) - Spire2 gene Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703, PubMed:21983562). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:21983562). Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (By similarity). Indicus|evm.model.CM009508.1.190 Q8WWL2 SPIR2_HUMAN 86.772 0.878505 0.29972 SPIRE2 - Protein spire homolog 2 - Homo sapiens (Human) - SPIRE2 gene Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Indicus|evm.model.CM009508.1.191 Q8R3L2 TCF25_MOUSE 82.055 0.97054 0.903846 Tcf25 - Transcription factor 25 - Mus musculus (Mouse) - Tcf25 gene May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development (By similarity). Indicus|evm.model.CM009508.1.192 P47798 MSHR_BOVIN 99.685 0.993711 1.00315 MC1R - Melanocyte-stimulating hormone receptor - Bos taurus (Bovine) - MC1R gene Receptor for MSH (alpha, beta) and ACTH (PubMed:8034052). Does not seem to be active with gamma-MSH (PubMed:8034052). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:8034052). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity). Indicus|evm.model.CM009508.1.193 Q60HC2 TBB3_MACFA 100.000 0.995565 1.00222 TUBB3 - Tubulin beta-3 chain - Macaca fascicularis (Crab-eating macaque) - TUBB3 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and maintenance (By similarity). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity). Indicus|evm.model.CM009508.1.194 A5PJM7 DEFI8_BOVIN 94.725 0.995604 1.0179 DEF8 - Differentially expressed in FDCP 8 homolog - Bos taurus (Bovine) - DEF8 gene Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. Indicus|evm.model.CM009508.1.195 B2RD01 CENP1_HUMAN 79.412 0.348958 1.02674 CENPBD1 - CENPB DNA-binding domain-containing protein 1 - Homo sapiens (Human) - CENPBD1 gene Indicus|evm.model.CM009508.1.196 Q920A7 AFG31_MOUSE 81.234 0.972938 0.983523 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Indicus|evm.model.CM009508.1.197 A6H7B4 DBND1_BOVIN 100.000 0.985915 0.898734 DBNDD1 - Dysbindin domain-containing protein 1 - Bos taurus (Bovine) - DBNDD1 gene negative regulation of protein kinase activity Indicus|evm.model.CM009508.1.198 A5D7M3 DRC4_BOVIN 99.582 0.924419 1.0795 GAS8 - Dynein regulatory complex subunit 4 - Bos taurus (Bovine) - GAS8 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner. Indicus|evm.model.CM009508.1.199 Q9CRB3 HIUH_MOUSE 79.661 0.823944 1.20339 Urah - 5-hydroxyisourate hydrolase - Mus musculus (Mouse) - Urah gene Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). Indicus|evm.model.CM009508.1.200 Q8NEM2 SHCBP_HUMAN 89.911 0.997037 1.00446 SHCBP1 - SHC SH2 domain-binding protein 1 - Homo sapiens (Human) - SHCBP1 gene May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. Indicus|evm.model.CM009508.1.201 Q3SZV2 KXDL1_BOVIN 97.727 0.988701 1.00568 KXD1 - KxDL motif-containing protein 1 - Bos taurus (Bovine) - KXD1 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May also be involved in the biogenesis of lysosome-related organelles such as melanosomes. Indicus|evm.model.CM009508.1.202 Q2HJG5 VPS35_BOVIN 100.000 0.997491 1.00126 VPS35 - Vacuolar protein sorting-associated protein 35 - Bos taurus (Bovine) - VPS35 gene Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for endosomal localization of WASHC2. Mediates the association of the CSC with the WASH complex via WASHC2. Required for the endosomal localization of TBC1D5 (By similarity). Indicus|evm.model.CM009508.1.203 Q2HJF3 ORC6_BOVIN 100.000 0.992095 1.00397 ORC6 - Origin recognition complex subunit 6 - Bos taurus (Bovine) - ORC6 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Indicus|evm.model.CM009508.1.204 Q32MK0 MYLK3_HUMAN 73.138 0.997459 0.960928 MYLK3 - Myosin light chain kinase 3 - Homo sapiens (Human) - MYLK3 gene Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). Indicus|evm.model.CM009508.1.205 Q32KT0 CP087_BOVIN 98.507 0.551867 1.56494 UPF0547 protein C16orf87 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009508.1.206 Q5EA40 BCAT2_BOVIN 60.625 0.77193 0.435115 BCAT2 - Branched-chain-amino-acid aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - BCAT2 gene Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). Indicus|evm.model.CM009508.1.207 Q8TD30 ALAT2_HUMAN 96.750 0.996183 1.00191 GPT2 - Alanine aminotransferase 2 - Homo sapiens (Human) - GPT2 gene Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Indicus|evm.model.CM009508.1.208 Q2HJ94 DNJA2_BOVIN 100.000 0.995157 1.00243 DNAJA2 - DnaJ homolog subfamily A member 2 precursor - Bos taurus (Bovine) - DNAJA2 gene Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Indicus|evm.model.CM009508.1.209 P24049 RL17_RAT 80.978 0.987013 0.836957 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009508.1.210 Q8NC67 NETO2_HUMAN 95.810 0.996146 0.988571 NETO2 - Neuropilin and tolloid-like protein 2 precursor - Homo sapiens (Human) - NETO2 gene Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity). Indicus|evm.model.CM009508.1.211 Q95KC8 TIP_MACFA 96.141 0.506536 1.96785 ITFG1 - T-cell immunomodulatory protein - Macaca fascicularis (Crab-eating macaque) - ITFG1 gene Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity). Indicus|evm.model.CM009508.1.212 P12798 KPBB_RABIT 87.569 0.984157 0.981702 PHKB - Phosphorylase b kinase regulatory subunit beta - Oryctolagus cuniculus (Rabbit) - PHKB gene Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. Indicus|evm.model.CM009508.1.213 Q5RFL9 NONO_PONAB 94.512 0.733032 0.469214 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009508.1.214 Q96J65 MRP9_HUMAN 87.482 0.994883 1.00662 ABCC12 - ATP-binding cassette sub-family C member 12 - Homo sapiens (Human) - ABCC12 gene Probable transporter, its substrate specificity is unknown. Indicus|evm.model.CM009508.1.215 Q96J66 MRP8_HUMAN 76.052 0.230712 0.965991 ABCC11 - ATP-binding cassette sub-family C member 11 - Homo sapiens (Human) - ABCC11 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Enhances also the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate (PubMed:25896536, PubMed:15537867, PubMed:12764137). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689, PubMed:12764137, PubMed:15537867, PubMed:16444273, PubMed:19383836, PubMed:25896536). Indicus|evm.model.CM009508.1.216 Q3SX23 LONP2_BOVIN 99.648 0.997655 1.00117 LONP2 - Lon protease homolog 2, peroxisomal - Bos taurus (Bovine) - LONP2 gene ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. Indicus|evm.model.CM009508.1.217 Q8IUQ4 SIAH1_HUMAN 99.645 0.894904 1.11348 SIAH1 - E3 ubiquitin-protein ligase SIAH1 - Homo sapiens (Human) - SIAH1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:10747903, PubMed:11146551, PubMed:11389839, PubMed:11389840, PubMed:11483517, PubMed:11483518, PubMed:11752454, PubMed:12072443). Confers constitutive instability to HIPK2 through proteasomal degradation (PubMed:18536714). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Has some overlapping function with SIAH2 (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (By similarity). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Indicus|evm.model.CM009508.1.219 O75113 N4BP1_HUMAN 88.876 0.997732 0.984375 N4BP1 - NEDD4-binding protein 1 - Homo sapiens (Human) - N4BP1 gene Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). Indicus|evm.model.CM009508.1.220 P63182 CBLN1_RAT 100.000 0.989691 1.00518 Cbln1 - Cerebellin-1 precursor - Rattus norvegicus (Rat) - Cbln1 gene Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (By similarity). Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (By similarity). Indicus|evm.model.CM009508.1.221 Q8WTQ4 CP078_HUMAN 60.650 0.992754 1.04151 C16orf78 - Uncharacterized protein C16orf78 - Homo sapiens (Human) - C16orf78 gene nucleus Indicus|evm.model.CM009508.1.223 Q2M1K9 ZN423_HUMAN 98.594 0.989172 1.00701 ZNF423 - Zinc finger protein 423 - Homo sapiens (Human) - ZNF423 gene Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. Indicus|evm.model.CM009508.1.224 Q6A058 ARMX2_MOUSE 79.100 0.653277 0.603316 Armcx2 - Armadillo repeat-containing X-linked protein 2 - Mus musculus (Mouse) - Armcx2 gene May regulate the dynamics and distribution of mitochondria in neural cells. Indicus|evm.model.CM009508.1.225 Q5R7J7 NEPR1_PONAB 100.000 0.984127 1.008 CNEP1R1 - Nuclear envelope phosphatase-regulatory subunit 1 - Pongo abelii (Sumatran orangutan) - CNEP1R1 gene Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity). Indicus|evm.model.CM009508.1.226 Q7Z4Q2 HEAT3_HUMAN 89.706 0.997059 1 HEATR3 - HEAT repeat-containing protein 3 - Homo sapiens (Human) - HEATR3 gene unfolded protein binding, protein import into nucleus, ribosomal large subunit biogenesis Indicus|evm.model.CM009508.1.227 Q68ED3 PAPD5_MOUSE 95.706 0.995918 0.774092 Tent4b - Terminal nucleotidyltransferase 4B - Mus musculus (Mouse) - Tent4b gene Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (By similarity). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (By similarity). Indicus|evm.model.CM009508.1.228 Q29450 ADCY7_BOVIN 98.888 0.980874 1.01855 ADCY7 - Adenylate cyclase type 7 - Bos taurus (Bovine) - ADCY7 gene Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors. Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (By similarity). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (By similarity). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity). Indicus|evm.model.CM009508.1.229 Q9NPI1 BRD7_HUMAN 92.154 0.995399 1.00154 BRD7 - Bromodomain-containing protein 7 - Homo sapiens (Human) - BRD7 gene Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. Indicus|evm.model.CM009508.1.230 Q969G9 NKD1_HUMAN 89.378 0.871041 0.940426 NKD1 - Protein naked cuticle homolog 1 - Homo sapiens (Human) - NKD1 gene Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Indicus|evm.model.CM009508.1.231 Q2T9W1 SNX20_BOVIN 99.618 0.992395 0.832278 SNX20 - Sorting nexin-20 - Bos taurus (Bovine) - SNX20 gene May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. Indicus|evm.model.CM009508.1.232 Q6E804 NOD2_BOVIN 99.506 0.998028 1.00099 NOD2 - Nucleotide-binding oligomerization domain-containing protein 2 - Bos taurus (Bovine) - NOD2 gene Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages. Component of an autophagy-mediated antibacterial pathway together with ATG16L1. Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon. Indicus|evm.model.CM009508.1.233 Q1RMU2 CYLD_BOVIN 99.895 0.997904 1.00105 CYLD - Ubiquitin carboxyl-terminal hydrolase CYLD - Bos taurus (Bovine) - CYLD gene Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (By similarity). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins. Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (By similarity). Indicus|evm.model.CM009508.1.234 Q9NSC2 SALL1_HUMAN 92.151 0.998481 0.994713 SALL1 - Sal-like protein 1 - Homo sapiens (Human) - SALL1 gene Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development. Indicus|evm.model.CM009508.1.235 Q9C056 NKX62_HUMAN 92.405 0.615686 0.920578 NKX6-2 - Homeobox protein Nkx-6.2 - Homo sapiens (Human) - NKX6-2 gene Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions. Indicus|evm.model.CM009508.1.236 O15405 TOX3_HUMAN 94.667 0.625 0.819444 TOX3 - TOX high mobility group box family member 3 - Homo sapiens (Human) - TOX3 gene Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. Indicus|evm.model.CM009508.1.238 Q3L8U1 CHD9_HUMAN 96.438 0.81983 0.933034 CHD9 - Chromodomain-helicase-DNA-binding protein 9 - Homo sapiens (Human) - CHD9 gene Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). Indicus|evm.model.CM009508.1.239 Q08999 RBL2_HUMAN 96.053 0.998247 1.00176 RBL2 - Retinoblastoma-like protein 2 - Homo sapiens (Human) - RBL2 gene Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. Indicus|evm.model.CM009508.1.240 Q5RE48 AKTIP_PONAB 98.294 0.993197 1.00341 AKTIP - AKT-interacting protein - Pongo abelii (Sumatran orangutan) - AKTIP gene Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. Indicus|evm.model.CM009508.1.242 Q68CZ1 FTM_HUMAN 87.092 0.99842 0.962738 RPGRIP1L - Protein fantom - Homo sapiens (Human) - RPGRIP1L gene Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (PubMed:19464661). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (PubMed:19464661). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (By similarity). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (By similarity). Indicus|evm.model.CM009508.1.244 P78415 IRX3_HUMAN 90.079 0.996024 1.00399 IRX3 - Iroquois-class homeodomain protein IRX-3 - Homo sapiens (Human) - IRX3 gene Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. Indicus|evm.model.CM009508.1.247 P78411 IRX5_HUMAN 98.344 0.995868 1.00207 IRX5 - Iroquois-class homeodomain protein IRX-5 - Homo sapiens (Human) - IRX5 gene Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. Indicus|evm.model.CM009508.1.249 P78412 IRX6_HUMAN 83.482 0.995516 1 IRX6 - Iroquois-class homeodomain protein IRX-6 - Homo sapiens (Human) - IRX6 gene chromatin, nucleus, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cell development, neuron differentiation, positive regulation of transcription, DNA-templated, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009508.1.250 Q9GLE5 MMP2_BOVIN 99.546 0.996979 1.00151 MMP2 - 72 kDa type IV collagenase precursor - Bos taurus (Bovine) - MMP2 gene Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity). Indicus|evm.model.CM009508.1.251 Q7L5N7 PCAT2_HUMAN 83.088 0.996094 0.941176 LPCAT2 - Lysophosphatidylcholine acyltransferase 2 - Homo sapiens (Human) - LPCAT2 gene Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:20363836). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198). Indicus|evm.model.CM009508.1.252 P51143 SC6A2_BOVIN 99.837 0.996753 1.00163 SLC6A2 - Sodium-dependent noradrenaline transporter - Bos taurus (Bovine) - SLC6A2 gene Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. Indicus|evm.model.CM009508.1.253 Q56JZ1 RL13_BOVIN 92.417 0.990521 1 RPL13 - 60S ribosomal protein L13 - Bos taurus (Bovine) - RPL13 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development. Indicus|evm.model.CM009508.1.254 Q29550 EST1_PIG 81.625 0.996473 1.00177 Liver carboxylesterase precursor - Sus scrofa (Pig) Indicus|evm.model.CM009508.1.256 Q29550 EST1_PIG 79.682 0.996473 1.00177 Liver carboxylesterase precursor - Sus scrofa (Pig) Indicus|evm.model.CM009508.1.260 Q9BXC9 BBS2_HUMAN 91.678 0.99723 1.00139 BBS2 - Bardet-Biedl syndrome 2 protein - Homo sapiens (Human) - BBS2 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Indicus|evm.model.CM009508.1.261 Q3MI03 OGFD1_BOVIN 100.000 0.996317 1.00185 OGFOD1 - Prolyl 3-hydroxylase OGFOD1 - Bos taurus (Bovine) - OGFOD1 gene Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation. Indicus|evm.model.CM009508.1.262 Q5RAI8 CPSF5_PONAB 100.000 0.991228 1.00441 NUDT21 - Cleavage and polyadenylation specificity factor subunit 5 - Pongo abelii (Sumatran orangutan) - NUDT21 gene Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7. Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function. Binds to chromatin. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. Indicus|evm.model.CM009508.1.263 Q9UKV5 AMFR_HUMAN 95.341 0.945671 0.916019 AMFR - E3 ubiquitin-protein ligase AMFR - Homo sapiens (Human) - AMFR gene E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Indicus|evm.model.CM009508.1.264 P08239 GNAO_BOVIN 100.000 0.982143 0.316384 GNAO1 - Guanine nucleotide-binding protein G(o) subunit alpha - Bos taurus (Bovine) - GNAO1 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity). Indicus|evm.model.CM009508.1.265 P09471 GNAO_HUMAN 92.938 0.994286 0.988701 GNAO1 - Guanine nucleotide-binding protein G(o) subunit alpha - Homo sapiens (Human) - GNAO1 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Indicus|evm.model.CM009508.1.266 Q3T930 EST5A_SHEEP 95.276 0.758483 1.31496 CES5A - Carboxylesterase 5A - Ovis aries (Sheep) - CES5A gene Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Indicus|evm.model.CM009508.1.267 Q29550 EST1_PIG 78.269 0.996466 1 Liver carboxylesterase precursor - Sus scrofa (Pig) Indicus|evm.model.CM009508.1.268 Q86U42 PABP2_HUMAN 98.876 0.988827 0.584967 PABPN1 - Polyadenylate-binding protein 2 - Homo sapiens (Human) - PABPN1 gene Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Indicus|evm.model.CM009508.1.269 A5PJZ5 NUP93_BOVIN 100.000 0.887202 1.12576 NUP93 - Nuclear pore complex protein Nup93 - Bos taurus (Bovine) - NUP93 gene Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling. Indicus|evm.model.CM009508.1.270 P55017 S12A3_HUMAN 92.039 0.99806 1.00979 SLC12A3 - Solute carrier family 12 member 3 - Homo sapiens (Human) - SLC12A3 gene Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:21613606, PubMed:22009145). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (By similarity). Indicus|evm.model.CM009508.1.271 Q15011 HERP1_HUMAN 88.918 0.992188 0.982097 HERPUD1 - Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein - Homo sapiens (Human) - HERPUD1 gene Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405). Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982). Indicus|evm.model.CM009508.1.273 Q86WI3 NLRC5_HUMAN 72.320 0.998929 1.00107 NLRC5 - Protein NLRC5 - Homo sapiens (Human) - NLRC5 gene Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. Indicus|evm.model.CM009508.1.274 Q96FN4 CPNE2_HUMAN 96.715 0.949653 1.05109 CPNE2 - Copine-2 - Homo sapiens (Human) - CPNE2 gene Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties. Indicus|evm.model.CM009508.1.275 Q9GZU8 PIP30_HUMAN 94.094 0.992063 0.992126 PSME3IP1 - PSME3-interacting protein - Homo sapiens (Human) - PSME3IP1 gene Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus. Indicus|evm.model.CM009508.1.277 Q95LP3 RSPRY_MACFA 97.049 0.996534 1.00174 RSPRY1 - RING finger and SPRY domain-containing protein 1 precursor - Macaca fascicularis (Crab-eating macaque) - RSPRY1 gene Indicus|evm.model.CM009508.1.278 Q32PC9 AR2BP_BOVIN 100.000 0.987805 1.00613 ARL2BP - ADP-ribosylation factor-like protein 2-binding protein - Bos taurus (Bovine) - ARL2BP gene Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). Indicus|evm.model.CM009508.1.279 A6H7B0 PLLP_BOVIN 100.000 0.814371 0.917582 PLLP - Plasmolipin - Bos taurus (Bovine) - PLLP gene Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). Indicus|evm.model.CM009508.1.280 A6H7B0 PLLP_BOVIN 100.000 0.294574 0.708791 PLLP - Plasmolipin - Bos taurus (Bovine) - PLLP gene Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). Indicus|evm.model.CM009508.1.281 O00626 CCL22_HUMAN 76.389 0.755319 1.01075 CCL22 - C-C motif chemokine 22 precursor - Homo sapiens (Human) - CCL22 gene May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Indicus|evm.model.CM009508.1.282 O55145 X3CL1_RAT 57.419 0.328976 1.16794 Cx3cl1 - Fractalkine precursor - Rattus norvegicus (Rat) - Cx3cl1 gene Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. Indicus|evm.model.CM009508.1.283 Q8I021 CCL17_FELCA 61.333 0.718447 1.0404 CCL17 - C-C motif chemokine 17 precursor - Felis catus (Cat) - CCL17 gene Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). Indicus|evm.model.CM009508.1.284 Q5EAC7 CPIN1_BOVIN 99.357 0.99359 1.00645 CIAPIN1 - Anamorsin - Bos taurus (Bovine) - CIAPIN1 gene Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. Indicus|evm.model.CM009508.1.285 Q2NL34 COQ9_BOVIN 99.687 0.99375 1.00313 COQ9 - Ubiquinone biosynthesis protein COQ9, mitochondrial precursor - Bos taurus (Bovine) - COQ9 gene Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7. Indicus|evm.model.CM009508.1.286 Q3T0Q3 RPB3_BOVIN 100.000 0.992754 1.00364 POLR2C - DNA-directed RNA polymerase II subunit RPB3 - Bos taurus (Bovine) - POLR2C gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). Indicus|evm.model.CM009508.1.287 Q8TEW6 DOK4_HUMAN 98.466 0.993884 1.00307 DOK4 - Docking protein 4 - Homo sapiens (Human) - DOK4 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. Indicus|evm.model.CM009508.1.288 A0JNH6 C102A_BOVIN 100.000 0.996403 1.0018 CCDC102A - Coiled-coil domain-containing protein 102A - Bos taurus (Bovine) - CCDC102A gene Indicus|evm.model.CM009508.1.289 Q8IZF4 AGRG5_HUMAN 75.394 0.976654 0.973485 ADGRG5 - Adhesion G-protein coupled receptor G5 precursor - Homo sapiens (Human) - ADGRG5 gene Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). Indicus|evm.model.CM009508.1.290 Q50DM6 AGRG1_GORGO 82.439 0.836401 0.71179 ADGRG1 - Adhesion G-protein coupled receptor G1 precursor - Gorilla gorilla gorilla (Western lowland gorilla) - ADGRG1 gene Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity).Plays an essential role in testis development. Plays a critical role in tumourigenesis. Indicus|evm.model.CM009508.1.291 Q8K209 AGRG1_MOUSE 91.163 0.699346 0.445415 Adgrg1 - Adhesion G-protein coupled receptor G1 precursor - Mus musculus (Mouse) - Adgrg1 gene Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (PubMed:21768377). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (By similarity). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (PubMed:23478665). Plays a critical role in tumourigenesis (By similarity). Plays essential role in testis development (PubMed:20981830). Indicus|evm.model.CM009508.1.292 Q86Y34 AGRG3_HUMAN 66.126 0.99635 0.998179 ADGRG3 - Adhesion G protein-coupled receptor G3 precursor - Homo sapiens (Human) - ADGRG3 gene Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658). Indicus|evm.model.CM009508.1.293 Q2T9M4 DRC7_BOVIN 99.771 0.997709 1.00115 DRC7 - Dynein regulatory complex subunit 7 - Bos taurus (Bovine) - DRC7 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility. Indicus|evm.model.CM009508.1.294 Q9BVA0 KTNB1_HUMAN 95.626 0.996988 1.01374 KATNB1 - Katanin p80 WD40 repeat-containing subunit B1 - Homo sapiens (Human) - KATNB1 gene Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. Indicus|evm.model.CM009508.1.295 Q9BVG8 KIFC3_HUMAN 96.982 0.754404 1.15846 KIFC3 - Kinesin-like protein KIFC3 - Homo sapiens (Human) - KIFC3 gene Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. Indicus|evm.model.CM009508.1.297 Q28181 CNGB1_BOVIN 98.853 0.998558 0.994978 CNGB1 - Cyclic nucleotide-gated cation channel beta-1 - Bos taurus (Bovine) - CNGB1 gene Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP (By similarity). Indicus|evm.model.CM009508.1.298 Q2YDM5 TEPP_BOVIN 99.359 0.714286 1.39103 TEPP - Testis, prostate and placenta-expressed protein - Bos taurus (Bovine) - TEPP gene Indicus|evm.model.CM009508.1.299 Q9P2F9 ZN319_HUMAN 96.758 0.996593 1.00859 ZNF319 - Zinc finger protein 319 - Homo sapiens (Human) - ZNF319 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.300 Q0II50 USB1_BOVIN 99.623 0.992481 1.00377 USB1 - U6 snRNA phosphodiesterase - Bos taurus (Bovine) - USB1 gene Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Indicus|evm.model.CM009508.1.301 P51511 MMP15_HUMAN 89.778 0.997041 1.01046 MMP15 - Matrix metalloproteinase-15 precursor - Homo sapiens (Human) - MMP15 gene Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. Indicus|evm.model.CM009508.1.302 Q8BTU1 CFA20_MOUSE 100.000 0.989691 1.00518 Cfap20 - Cilia- and flagella-associated protein 20 - Mus musculus (Mouse) - Cfap20 gene Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Indicus|evm.model.CM009508.1.303 P20427 CSK22_BOVIN 99.684 0.990566 0.908571 CSNK2A2 - Casein kinase II subunit alpha' - Bos taurus (Bovine) - CSNK2A2 gene Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins (By similarity). Indicus|evm.model.CM009508.1.304 Q3SZX9 CC113_BOVIN 99.744 0.994898 1.00256 CCDC113 - Coiled-coil domain-containing protein 113 - Bos taurus (Bovine) - CCDC113 gene Component of centriolar satellites contributing to primary cilium formation. Indicus|evm.model.CM009508.1.305 Q6PEW0 PRS54_HUMAN 58.869 0.846325 1.13671 PRSS54 - Inactive serine protease 54 precursor - Homo sapiens (Human) - PRSS54 gene extracellular space, serine-type endopeptidase activity, proteolysis Indicus|evm.model.CM009508.1.306 Q08E12 PSF3_BOVIN 100.000 0.990783 1.00463 GINS3 - DNA replication complex GINS protein PSF3 - Bos taurus (Bovine) - GINS3 gene The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. Indicus|evm.model.CM009508.1.307 Q9ULP0 NDRG4_HUMAN 94.493 0.844388 1.11364 NDRG4 - Protein NDRG4 - Homo sapiens (Human) - NDRG4 gene Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. Indicus|evm.model.CM009508.1.308 E1BI64 SETD6_BOVIN 99.333 0.995565 1.00222 SETD6 - N-lysine methyltransferase SETD6 - Bos taurus (Bovine) - SETD6 gene Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). Indicus|evm.model.CM009508.1.309 A5YKK6 CNOT1_HUMAN 99.747 0.999159 1.00042 CNOT1 - CCR4-NOT transcription complex subunit 1 - Homo sapiens (Human) - CNOT1 gene Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Indicus|evm.model.CM009508.1.311 A7E3U5 S38A7_BOVIN 100.000 0.99569 1.00216 SLC38A7 - Putative sodium-coupled neutral amino acid transporter 7 - Bos taurus (Bovine) - SLC38A7 gene Mediates sodium-dependent transport of amino acids, preferentially L-glutamine. Indicus|evm.model.CM009508.1.312 P12344 AATM_BOVIN 99.767 0.99536 1.00233 GOT2 - Aspartate aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - GOT2 gene Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. Indicus|evm.model.CM009508.1.314 P62936 PPIA_PIG 81.319 0.947368 0.579268 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009508.1.318 P55286 CADH8_HUMAN 99.595 0.921348 0.334168 CDH8 - Cadherin-8 precursor - Homo sapiens (Human) - CDH8 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009508.1.319 P55286 CADH8_HUMAN 72.170 0.686667 0.375469 CDH8 - Cadherin-8 precursor - Homo sapiens (Human) - CDH8 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009508.1.320 O54800 CADH8_RAT 98.974 0.552707 0.439299 Cdh8 - Cadherin-8 precursor - Rattus norvegicus (Rat) - Cdh8 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009508.1.321 P55286 CADH8_HUMAN 95.238 0.988095 0.105131 CDH8 - Cadherin-8 precursor - Homo sapiens (Human) - CDH8 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009508.1.322 Q3SZ90 RL13A_BOVIN 76.068 0.982906 0.576355 RPL13A - 60S ribosomal protein L13a - Bos taurus (Bovine) - RPL13A gene Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). Indicus|evm.model.CM009508.1.324 P55287 CAD11_HUMAN 98.744 0.997491 1.00126 CDH11 - Cadherin-11 precursor - Homo sapiens (Human) - CDH11 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009508.1.325 Q6URK6 CADH5_BOVIN 97.110 0.610108 0.353768 CDH5 - Cadherin-5 precursor - Bos taurus (Bovine) - CDH5 gene Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (By similarity). Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity). Indicus|evm.model.CM009508.1.326 Q6URK6 CADH5_BOVIN 99.672 0.996727 0.780332 CDH5 - Cadherin-5 precursor - Bos taurus (Bovine) - CDH5 gene Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (By similarity). Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity). Indicus|evm.model.CM009508.1.327 Q3B7T3 BEAN1_HUMAN 81.673 0.811258 1.16602 BEAN1 - Protein BEAN1 - Homo sapiens (Human) - BEAN1 gene Indicus|evm.model.CM009508.1.329 Q9N0C5 KITM_MACFA 82.772 0.952899 1.04151 TK2 - Thymidine kinase 2, mitochondrial precursor - Macaca fascicularis (Crab-eating macaque) - TK2 gene Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents. Indicus|evm.model.CM009508.1.330 Q9UBR5 CKLF_HUMAN 73.649 0.98 0.986842 CKLF - Chemokine-like factor - Homo sapiens (Human) - CKLF gene May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10. Indicus|evm.model.CM009508.1.331 Q8IZ96 CKLF1_HUMAN 59.006 0.423913 2.17751 CMTM1 - CKLF-like MARVEL transmembrane domain-containing protein 1 - Homo sapiens (Human) - CMTM1 gene integral component of membrane Indicus|evm.model.CM009508.1.332 Q8TAZ6 CKLF2_HUMAN 59.375 0.803419 0.943548 CMTM2 - CKLF-like MARVEL transmembrane domain-containing protein 2 - Homo sapiens (Human) - CMTM2 gene integral component of membrane Indicus|evm.model.CM009508.1.333 Q96MX0 CKLF3_HUMAN 90.977 0.804878 0.901099 CMTM3 - CKLF-like MARVEL transmembrane domain-containing protein 3 - Homo sapiens (Human) - CMTM3 gene cytoplasmic vesicle, cytosol, integral component of membrane Indicus|evm.model.CM009508.1.334 Q8CJ61 CKLF4_MOUSE 97.115 0.990431 1.00481 Cmtm4 - CKLF-like MARVEL transmembrane domain-containing protein 4 - Mus musculus (Mouse) - Cmtm4 gene Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation. Indicus|evm.model.CM009508.1.335 O43237 DC1L2_HUMAN 98.374 0.995943 1.00203 DYNC1LI2 - Cytoplasmic dynein 1 light intermediate chain 2 - Homo sapiens (Human) - DYNC1LI2 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Indicus|evm.model.CM009508.1.336 Q13564 ULA1_HUMAN 97.211 0.456284 2.05618 NAE1 - NEDD8-activating enzyme E1 regulatory subunit - Homo sapiens (Human) - NAE1 gene Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. Indicus|evm.model.CM009508.1.337 P43166 CAH7_HUMAN 95.076 0.992453 1.00379 CA7 - Carbonic anhydrase 7 - Homo sapiens (Human) - CA7 gene Reversible hydration of carbon dioxide. Indicus|evm.model.CM009508.1.338 Q9P2J9 PDP2_HUMAN 87.170 0.994361 1.00567 PDP2 - [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor - Homo sapiens (Human) - PDP2 gene Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. Indicus|evm.model.CM009508.1.339 O75309 CAD16_HUMAN 80.700 0.99759 1.00121 CDH16 - Cadherin-16 precursor - Homo sapiens (Human) - CDH16 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009508.1.340 P55042 RAD_HUMAN 95.455 0.993528 1.00325 RRAD - GTP-binding protein RAD - Homo sapiens (Human) - RRAD gene May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. Indicus|evm.model.CM009508.1.341 Q9Y3D0 CIA2B_HUMAN 87.363 0.989071 1.1227 CIAO2B - Cytosolic iron-sulfur assembly component 2B - Homo sapiens (Human) - CIAO2B gene Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004, PubMed:22678362, PubMed:22678361, PubMed:29848660). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004, PubMed:29848660). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660). Indicus|evm.model.CM009508.1.342 O00748 EST2_HUMAN 72.333 0.98556 0.991055 CES2 - Cocaine esterase precursor - Homo sapiens (Human) - CES2 gene Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984). Indicus|evm.model.CM009508.1.343 Q5RCL7 EST3_PONAB 71.250 0.977233 1.00351 CES3 - Carboxylesterase 3 precursor - Pongo abelii (Sumatran orangutan) - CES3 gene Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Indicus|evm.model.CM009508.1.344 P0C6R3 EST4A_BOVIN 98.701 0.981752 0.996364 CES4A - Carboxylesterase 4A precursor - Bos taurus (Bovine) - CES4A gene Probable carboxylesterase. Indicus|evm.model.CM009508.1.345 Q13951 PEBB_HUMAN 99.451 0.989071 1.00549 CBFB - Core-binding factor subunit beta - Homo sapiens (Human) - CBFB gene Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. Indicus|evm.model.CM009508.1.346 Q9BSU1 CP070_HUMAN 97.393 0.995272 1.00237 PHAF1 - Phagosome assembly factor 1 - Homo sapiens (Human) - PHAF1 gene Plays a regulatory role in autophagic activity. In complex with BCAS3, associates with the autophagosome formation site during both non-selective and selective autophagy. Indicus|evm.model.CM009508.1.347 Q17QZ8 B3GN9_BOVIN 100.000 0.995025 1.00249 B3GNT9 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 - Bos taurus (Bovine) - B3GNT9 gene Golgi apparatus, acetylgalactosaminyltransferase activity, acetylglucosaminyltransferase activity, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity, poly-N-acetyllactosamine biosynthetic process, protein glycosylation Indicus|evm.model.CM009508.1.348 Q2KI74 TRADD_BOVIN 100.000 0.99361 1.00321 TRADD - Tumor necrosis factor receptor type 1-associated DEATH domain protein - Bos taurus (Bovine) - TRADD gene Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Indicus|evm.model.CM009508.1.349 Q08DG4 FBXL8_BOVIN 99.733 0.994667 1.00267 FBXL8 - F-box/LRR-repeat protein 8 - Bos taurus (Bovine) - FBXL8 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009508.1.350 Q1HGE8 HSF4_CANLF 92.886 0.995927 0.997967 HSF4 - Heat shock factor protein 4 - Canis lupus familiaris (Dog) - HSF4 gene DNA-binding protein that specifically binds heat shock promoter elements (HSE). Indicus|evm.model.CM009508.1.351 O60936 NOL3_HUMAN 87.919 0.714976 0.995192 NOL3 - Nucleolar protein 3 - Homo sapiens (Human) - NOL3 gene May be involved in RNA splicing. Indicus|evm.model.CM009508.1.352 Q0VCR8 EX3L1_BOVIN 99.852 0.517638 1.76455 EXOC3L1 - Exocyst complex component 3-like protein - Bos taurus (Bovine) - EXOC3L1 gene As part of the exocyst, may play a role in regulated exocytosis of insulin granules. Indicus|evm.model.CM009508.1.353 Q16254 E2F4_HUMAN 86.605 0.995283 1.02663 E2F4 - Transcription factor E2F4 - Homo sapiens (Human) - E2F4 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Indicus|evm.model.CM009508.1.354 A6QR40 ELMO3_BOVIN 99.846 0.901526 1.10583 ELMO3 - Engulfment and cell motility protein 3 - Bos taurus (Bovine) - ELMO3 gene Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). Indicus|evm.model.CM009508.1.355 Q8WV35 LRC29_HUMAN 82.659 0.276527 2.78924 LRRC29 - Leucine-rich repeat-containing protein 29 - Homo sapiens (Human) - LRRC29 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Indicus|evm.model.CM009508.1.356 Q3SZZ5 TM208_BOVIN 100.000 0.988506 1.00578 TMEM208 - Transmembrane protein 208 - Bos taurus (Bovine) - TMEM208 gene May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. Indicus|evm.model.CM009508.1.357 Q9Y613 FHOD1_HUMAN 92.559 0.529355 0.892612 FHOD1 - FH1/FH2 domain-containing protein 1 - Homo sapiens (Human) - FHOD1 gene Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. Indicus|evm.model.CM009508.1.358 Q9Z0X2 SL9A5_RAT 96.041 0.980022 1.00334 Slc9a5 - Sodium/hydrogen exchanger 5 - Rattus norvegicus (Rat) - Slc9a5 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity). Indicus|evm.model.CM009508.1.359 Q58EX7 PKHG4_HUMAN 80.535 0.998329 1.00504 PLEKHG4 - Puratrophin-1 - Homo sapiens (Human) - PLEKHG4 gene Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. Indicus|evm.model.CM009508.1.360 A7YWH3 KCD19_BOVIN 100.000 0.997845 1.00108 KCTD19 - BTB/POZ domain-containing protein KCTD19 - Bos taurus (Bovine) - KCTD19 gene Indicus|evm.model.CM009508.1.361 Q1X8D7 LRC36_HUMAN 85.960 0.994702 1.00133 LRRC36 - Leucine-rich repeat-containing protein 36 - Homo sapiens (Human) - LRRC36 gene Indicus|evm.model.CM009508.1.362 Q3ZCC8 TPPP3_BOVIN 100.000 0.988701 1.00568 TPPP3 - Tubulin polymerization-promoting protein family member 3 - Bos taurus (Bovine) - TPPP3 gene Regulator of microtubule dynamic that has microtubule bundling activity (By similarity). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin (By similarity). Indicus|evm.model.CM009508.1.363 Q8WTX9 ZDHC1_HUMAN 96.765 0.701863 0.995876 ZDHHC1 - Palmitoyltransferase ZDHHC1 - Homo sapiens (Human) - ZDHHC1 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (By similarity). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation. Indicus|evm.model.CM009508.1.364 P50168 DHI2_SHEEP 99.160 0.879012 0.948478 HSD11B2 - Corticosteroid 11-beta-dehydrogenase isozyme 2 - Ovis aries (Sheep) - HSD11B2 gene Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Indicus|evm.model.CM009508.1.365 Q5R6I1 VA0D1_PONAB 100.000 0.994318 1.00285 ATP6V0D1 - V-type proton ATPase subunit d 1 - Pongo abelii (Sumatran orangutan) - ATP6V0D1 gene Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). Indicus|evm.model.CM009508.1.366 P56413 AGRP_BOVIN 98.507 0.985185 1.00746 AGRP - Agouti-related protein precursor - Bos taurus (Bovine) - AGRP gene Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. Indicus|evm.model.CM009508.1.368 Q68FE6 RIPR1_MOUSE 95.522 0.638756 0.341783 Ripor1 - Rho family-interacting cell polarization regulator 1 - Mus musculus (Mouse) - Ripor1 gene Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation. Indicus|evm.model.CM009508.1.369 P49711 CTCF_HUMAN 99.450 0.997253 1.00138 CTCF - Transcriptional repressor CTCF - Homo sapiens (Human) - CTCF gene Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays an important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X- inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19. Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640). Indicus|evm.model.CM009508.1.370 Q6F5E8 CARL2_HUMAN 87.786 0.290419 0.93101 CARMIL2 - Capping protein, Arp2/3 and myosin-I linker protein 2 - Homo sapiens (Human) - CARMIL2 gene Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647349, PubMed:27647348, PubMed:28112205). Indicus|evm.model.CM009508.1.371 Q96AP0 ACD_HUMAN 71.616 0.866412 1.1441 ACD - Adrenocortical dysplasia protein homolog - Homo sapiens (Human) - ACD gene Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. Indicus|evm.model.CM009508.1.372 Q9NPB6 PAR6A_HUMAN 95.954 0.994203 0.99711 PARD6A - Partitioning defective 6 homolog alpha - Homo sapiens (Human) - PARD6A gene Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). Indicus|evm.model.CM009508.1.373 Q3T078 ENKD1_BOVIN 99.425 0.994269 1.00287 ENKD1 - Enkurin domain-containing protein 1 - Bos taurus (Bovine) - ENKD1 gene cytoplasmic microtubule Indicus|evm.model.CM009508.1.374 Q6ZW13 CP086_HUMAN 70.717 0.99375 1.00946 C16orf86 - Uncharacterized protein C16orf86 - Homo sapiens (Human) - C16orf86 gene Indicus|evm.model.CM009508.1.375 Q5BIP5 GFOD2_BOVIN 100.000 0.994819 1.0026 GFOD2 - Glucose-fructose oxidoreductase domain-containing protein 2 precursor - Bos taurus (Bovine) - GFOD2 gene Promotes matrix assembly. Indicus|evm.model.CM009508.1.376 A3KMV8 RBP10_BOVIN 99.839 0.996779 1.00161 RANBP10 - Ran-binding protein 10 - Bos taurus (Bovine) - RANBP10 gene May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). Indicus|evm.model.CM009508.1.377 Q2TAA8 TXIP1_HUMAN 84.043 0.878179 1.13526 TSNAXIP1 - Translin-associated factor X-interacting protein 1 - Homo sapiens (Human) - TSNAXIP1 gene Possible role in spermatogenesis. Indicus|evm.model.CM009508.1.378 Q4R5U8 CENPT_MACFA 68.687 0.860927 0.807487 CENPT - Centromere protein T - Macaca fascicularis (Crab-eating macaque) - CENPT gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. Indicus|evm.model.CM009508.1.379 A5PKF5 THA11_BOVIN 100.000 0.993421 1.0033 THAP11 - THAP domain-containing protein 11 - Bos taurus (Bovine) - THAP11 gene Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity). Indicus|evm.model.CM009508.1.380 P61972 NTF2_RAT 100.000 0.984375 1.00787 Nutf2 - Nuclear transport factor 2 - Rattus norvegicus (Rat) - Nutf2 gene Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. Indicus|evm.model.CM009508.1.381 Q6P2E9 EDC4_HUMAN 95.357 0.997145 1 EDC4 - Enhancer of mRNA-decapping protein 4 - Homo sapiens (Human) - EDC4 gene In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). Indicus|evm.model.CM009508.1.382 Q496H8 NRN1L_HUMAN 83.838 0.576471 1.0303 NRN1L - Neuritin-like protein precursor - Homo sapiens (Human) - NRN1L gene extracellular region, plasma membrane Indicus|evm.model.CM009508.1.384 Q0V7M1 KPSH1_BOVIN 100.000 0.995294 1.00236 PSKH1 - Serine/threonine-protein kinase H1 - Bos taurus (Bovine) - PSKH1 gene May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. Indicus|evm.model.CM009508.1.385 Q3T0T1 PSB10_BOVIN 100.000 0.984496 0.945055 PSMB10 - Proteasome subunit beta type-10 precursor - Bos taurus (Bovine) - PSMB10 gene The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity). Indicus|evm.model.CM009508.1.386 P04180 LCAT_HUMAN 91.224 0.979592 1.00227 LCAT - Phosphatidylcholine-sterol acyltransferase precursor - Homo sapiens (Human) - LCAT gene Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:8016111). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (PubMed:8016111). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (PubMed:24620755). Indicus|evm.model.CM009508.1.387 Q28677 S12A4_RABIT 96.679 0.544186 1.78341 SLC12A4 - Solute carrier family 12 member 4 - Oryctolagus cuniculus (Rabbit) - SLC12A4 gene Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Indicus|evm.model.CM009508.1.388 Q9NUL7 DDX28_HUMAN 85.000 0.987179 1.01111 DDX28 - Probable ATP-dependent RNA helicase DDX28 - Homo sapiens (Human) - DDX28 gene Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955). Indicus|evm.model.CM009508.1.389 Q9NX74 DUS2L_HUMAN 91.684 0.995951 1.00203 DUS2 - tRNA-dihydrouridine(20) synthase [NAD(P)+]-like - Homo sapiens (Human) - DUS2 gene Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616). Indicus|evm.model.CM009508.1.390 Q12968 NFAC3_HUMAN 93.581 0.998138 0.99907 NFATC3 - Nuclear factor of activated T-cells, cytoplasmic 3 - Homo sapiens (Human) - NFATC3 gene Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Along with NFATC4, involved in embryonic heart development (By similarity). Indicus|evm.model.CM009508.1.391 Q8K0G8 ESRP2_MOUSE 94.286 0.973538 1.00139 Esrp2 - Epithelial splicing regulatory protein 2 - Mus musculus (Mouse) - Esrp2 gene mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Indicus|evm.model.CM009508.1.392 Q8WMP9 PAG15_BOVIN 100.000 0.995098 1.00246 PLA2G15 - Phospholipase A2 group XV precursor - Bos taurus (Bovine) - PLA2G15 gene Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:11790796, PubMed:9525960). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:11790796, PubMed:9525960). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (By similarity). Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (By similarity). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress. Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity). Indicus|evm.model.CM009508.1.393 Q92536 YLAT2_HUMAN 89.903 0.996124 1.00194 SLC7A6 - Y+L amino acid transporter 2 - Homo sapiens (Human) - SLC7A6 gene Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells. Indicus|evm.model.CM009508.1.394 Q1JQE2 S7A6O_BOVIN 99.674 0.993506 1.00326 SLC7A6OS - Probable RNA polymerase II nuclear localization protein SLC7A6OS - Bos taurus (Bovine) - SLC7A6OS gene Directs RNA polymerase II nuclear import. Indicus|evm.model.CM009508.1.395 A6QQV6 ANM7_BOVIN 99.424 0.988588 1.00863 PRMT7 - Protein arginine N-methyltransferase 7 - Bos taurus (Bovine) - PRMT7 gene Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. Indicus|evm.model.CM009508.1.396 O35049 NSMA2_RAT 89.650 0.996956 1.00305 Smpd3 - Sphingomyelin phosphodiesterase 3 - Rattus norvegicus (Rat) - Smpd3 gene Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location (By similarity). Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions. Indicus|evm.model.CM009508.1.397 Q8TF47 ZFP90_HUMAN 90.267 0.996855 1 ZFP90 - Zinc finger protein 90 homolog - Homo sapiens (Human) - ZFP90 gene Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. Indicus|evm.model.CM009508.1.398 P19535 CADH3_BOVIN 100.000 0.49445 2.01833 CDH3 - Cadherin-3 - Bos taurus (Bovine) - CDH3 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009508.1.399 Q6R8F2 CADH1_BOVIN 98.673 0.969555 0.968254 CDH1 - Cadherin-1 precursor - Bos taurus (Bovine) - CDH1 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. Indicus|evm.model.CM009508.1.400 Q9C0B7 TNG6_HUMAN 86.106 0.985375 1 TANGO6 - Transport and Golgi organization protein 6 homolog - Homo sapiens (Human) - TANGO6 gene protein secretion Indicus|evm.model.CM009508.1.401 O00219 HYAS3_HUMAN 98.915 0.900489 1.1085 HAS3 - Hyaluronan synthase 3 - Homo sapiens (Human) - HAS3 gene Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity). Indicus|evm.model.CM009508.1.402 P0CG10 DERPC_BOVIN 99.815 0.996303 1.00185 DERPC - Decreased expression in renal and prostate cancer protein - Bos taurus (Bovine) - DERPC gene Potential tumor suppressor. Indicus|evm.model.CM009508.1.403 Q969X6 UTP4_HUMAN 91.837 0.997089 1.00146 UTP4 - U3 small nucleolar RNA-associated protein 4 homolog - Homo sapiens (Human) - UTP4 gene Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766). May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (PubMed:19732766). Indicus|evm.model.CM009508.1.404 Q13425 SNTB2_HUMAN 94.073 0.992395 0.974074 SNTB2 - Beta-2-syntrophin - Homo sapiens (Human) - SNTB2 gene Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. Indicus|evm.model.CM009508.1.405 Q793F9 VPS4A_RAT 98.856 0.995434 1.00229 Vps4a - Vacuolar protein sorting-associated protein 4A - Rattus norvegicus (Rat) - Vps4a gene Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Indicus|evm.model.CM009508.1.406 Q9HBH1 DEFM_HUMAN 82.174 0.912351 1.03292 PDF - Peptide deformylase, mitochondrial precursor - Homo sapiens (Human) - PDF gene Removes the formyl group from the N-terminal Met of newly synthesized proteins. Indicus|evm.model.CM009508.1.407 Q2TBH9 COG8_BOVIN 99.681 0.99681 1.0016 COG8 - Conserved oligomeric Golgi complex subunit 8 - Bos taurus (Bovine) - COG8 gene Required for normal Golgi function. Indicus|evm.model.CM009508.1.408 Q56P27 NIP7_PIG 98.889 0.98895 1.00556 NIP7 - 60S ribosome subunit biogenesis protein NIP7 homolog - Sus scrofa (Pig) - NIP7 gene Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly. Indicus|evm.model.CM009508.1.409 Q0VCA9 TMED6_BOVIN 99.583 0.788779 1.2625 TMED6 - Transmembrane emp24 domain-containing protein 6 precursor - Bos taurus (Bovine) - TMED6 gene COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, Golgi apparatus, endoplasmic reticulum to Golgi vesicle-mediated transport, Golgi organization, intracellular protein transport Indicus|evm.model.CM009508.1.410 Q15554 TERF2_HUMAN 91.321 0.972426 1.00369 TERF2 - Telomeric repeat-binding factor 2 - Homo sapiens (Human) - TERF2 gene Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length. Indicus|evm.model.CM009508.1.412 O43169 CYB5B_HUMAN 80.822 0.986395 0.98 CYB5B - Cytochrome b5 type B precursor - Homo sapiens (Human) - CYB5B gene Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. Indicus|evm.model.CM009508.1.413 O94916 NFAT5_HUMAN 94.137 0.998691 0.99804 NFAT5 - Nuclear factor of activated T-cells 5 - Homo sapiens (Human) - NFAT5 gene Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Indicus|evm.model.CM009508.1.414 P15559 NQO1_HUMAN 90.876 0.992727 1.00365 NQO1 - NAD(P)H dehydrogenase [quinone] 1 - Homo sapiens (Human) - NQO1 gene The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Indicus|evm.model.CM009508.1.415 Q3T042 NOB1_BOVIN 99.758 0.895652 1.1138 NOB1 - RNA-binding protein NOB1 - Bos taurus (Bovine) - NOB1 gene May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). Indicus|evm.model.CM009508.1.416 O00308 WWP2_HUMAN 95.287 0.989749 1.0092 WWP2 - NEDD4-like E3 ubiquitin-protein ligase WWP2 - Homo sapiens (Human) - WWP2 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. Indicus|evm.model.CM009508.1.417 Q3ZBD0 PSMD7_BOVIN 100.000 0.993808 1.00311 PSMD7 - 26S proteasome non-ATPase regulatory subunit 7 - Bos taurus (Bovine) - PSMD7 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Indicus|evm.model.CM009508.1.420 Q15911 ZFHX3_HUMAN 93.106 0.99946 1.00054 ZFHX3 - Zinc finger homeobox protein 3 - Homo sapiens (Human) - ZFHX3 gene Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). Indicus|evm.model.CM009508.1.421 Q8TBY8 PMFBP_HUMAN 75.470 0.922936 1.08242 PMFBP1 - Polyamine-modulated factor 1-binding protein 1 - Homo sapiens (Human) - PMFBP1 gene Required for normal spermatogenesis (PubMed:1770140, PubMed:30032984, PubMed:30298696). It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity (PubMed:30032984). May also be involved in the general organization of cellular cytoskeleton (By similarity). Indicus|evm.model.CM009508.1.422 Q17R09 PRP16_BOVIN 97.148 0.987624 0.987775 DHX38 - Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 - Bos taurus (Bovine) - DHX38 gene Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Indicus|evm.model.CM009508.1.423 Q9NX01 TXN4B_HUMAN 97.315 0.986667 1.00671 TXNL4B - Thioredoxin-like protein 4B - Homo sapiens (Human) - TXNL4B gene Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition. Indicus|evm.model.CM009508.1.424 Q2TBU0 HPT_BOVIN 99.750 0.586765 1.69576 HP - Haptoglobin precursor - Bos taurus (Bovine) - HP gene As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity). Indicus|evm.model.CM009508.1.425 Q5E9W3 PYRD_BOVIN 100.000 0.980952 0.265823 DHODH - Dihydroorotate dehydrogenase (quinone), mitochondrial precursor - Bos taurus (Bovine) - DHODH gene Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Indicus|evm.model.CM009508.1.426 Q7Z443 PK1L3_HUMAN 72.378 0.163678 0.998268 PKD1L3 - Polycystic kidney disease protein 1-like 3 precursor - Homo sapiens (Human) - PKD1L3 gene Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. Indicus|evm.model.CM009508.1.427 Q3ZBV1 IST1_BOVIN 99.451 0.994521 1.00275 IST1 - IST1 homolog - Bos taurus (Bovine) - IST1 gene ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST. Indicus|evm.model.CM009508.1.429 Q32KS7 ZN821_BOVIN 100.000 0.995157 1.00243 ZNF821 - Zinc finger protein 821 - Bos taurus (Bovine) - ZNF821 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.430 P0C7T5 ATX1L_HUMAN 92.743 0.997093 0.998549 ATXN1L - Ataxin-1-like - Homo sapiens (Human) - ATXN1L gene Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). Indicus|evm.model.CM009508.1.431 P62246 RS15A_RAT 99.231 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Indicus|evm.model.CM009508.1.432 O43747 AP1G1_HUMAN 96.305 0.997619 1.0219 AP1G1 - AP-1 complex subunit gamma-1 - Homo sapiens (Human) - AP1G1 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). Indicus|evm.model.CM009508.1.433 Q6ZVD8 PHLP2_HUMAN 93.348 0.972694 1.02419 PHLPP2 - PH domain leucine-rich repeat-containing protein phosphatase 2 - Homo sapiens (Human) - PHLPP2 gene Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). Indicus|evm.model.CM009508.1.435 Q58CZ9 ATTY_BOVIN 99.776 0.897384 1.11186 TAT - Tyrosine aminotransferase - Bos taurus (Bovine) - TAT gene Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine (By similarity). Indicus|evm.model.CM009508.1.436 Q8NCG5 CHST4_HUMAN 79.144 0.951531 1.01554 CHST4 - Carbohydrate sulfotransferase 4 - Homo sapiens (Human) - CHST4 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location. Indicus|evm.model.CM009508.1.437 P17027 ZNF23_HUMAN 84.424 0.890278 1.11975 ZNF23 - Zinc finger protein 23 - Homo sapiens (Human) - ZNF23 gene May be involved in transcriptional regulation. May have a role in embryonic development. Indicus|evm.model.CM009508.1.439 A0A1W2PR48 TLE7_HUMAN 66.140 0.995455 0.997732 TLE7 - Transducin-like enhancer protein 7 - Homo sapiens (Human) - TLE7 gene nucleus, transcription regulator complex, repressing transcription factor binding, transcription corepressor activity, negative regulation of canonical Wnt signaling pathway Indicus|evm.model.CM009508.1.440 Q3ZBY3 CALB2_BOVIN 99.631 0.992647 1.00369 CALB2 - Calretinin - Bos taurus (Bovine) - CALB2 gene Calretinin is a calcium-binding protein which is abundant in auditory neurons. Indicus|evm.model.CM009508.1.441 Q5RAY7 CMTR2_PONAB 87.139 0.992157 0.994798 CMTR2 - Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 - Pongo abelii (Sumatran orangutan) - CMTR2 gene S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs. Indicus|evm.model.CM009508.1.442 Q4G0P3 HYDIN_HUMAN 76.487 0.999385 0.953134 HYDIN - Hydrocephalus-inducing protein homolog - Homo sapiens (Human) - HYDIN gene Required for ciliary motility. Indicus|evm.model.CM009508.1.443 P59045 NAL11_HUMAN 45.745 0.547059 0.164569 NLRP11 - NACHT, LRR and PYD domains-containing protein 11 - Homo sapiens (Human) - NLRP11 gene Involved in inflammation. Indicus|evm.model.CM009508.1.444 Q2KIB9 RPP29_BOVIN 99.545 0.99095 1.00455 POP4 - Ribonuclease P protein subunit p29 - Bos taurus (Bovine) - POP4 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Indicus|evm.model.CM009508.1.445 Q96S99 PKHF1_HUMAN 91.756 0.992857 1.00358 PLEKHF1 - Pleckstrin homology domain-containing family F member 1 - Homo sapiens (Human) - PLEKHF1 gene May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. Indicus|evm.model.CM009508.1.446 Q08DM5 CS012_BOVIN 99.291 0.985915 1.00709 Protein C19orf12 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009508.1.447 P24864 CCNE1_HUMAN 86.450 0.936387 0.958537 CCNE1 - G1/S-specific cyclin-E1 - Homo sapiens (Human) - CCNE1 gene Essential for the control of the cell cycle at the G1/S (start) transition. Indicus|evm.model.CM009508.1.449 Q3B7M7 RMP_BOVIN 99.809 0.99619 1.00191 URI1 - Unconventional prefoldin RPB5 interactor - Bos taurus (Bovine) - URI1 gene Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region (By similarity). Indicus|evm.model.CM009508.1.450 O15090 ZN536_HUMAN 92.610 0.940537 1.06077 ZNF536 - Zinc finger protein 536 - Homo sapiens (Human) - ZNF536 gene May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'. Indicus|evm.model.CM009508.1.452 Q63HK5 TSH3_HUMAN 95.463 0.998071 0.959297 TSHZ3 - Teashirt homolog 3 - Homo sapiens (Human) - TSHZ3 gene Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). Indicus|evm.model.CM009508.1.454 P11309 PIM1_HUMAN 72.770 0.626263 0.948882 PIM1 - Serine/threonine-protein kinase pim-1 - Homo sapiens (Human) - PIM1 gene Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (PubMed:18056989). Promotes brown adipocyte differentiation (By similarity). Indicus|evm.model.CM009508.1.455 Q8NBZ7 UXS1_HUMAN 87.705 0.751553 0.383333 UXS1 - UDP-glucuronic acid decarboxylase 1 - Homo sapiens (Human) - UXS1 gene Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. Indicus|evm.model.CM009508.1.456 Q5R885 UXS1_PONAB 81.675 0.989583 0.457143 UXS1 - UDP-glucuronic acid decarboxylase 1 - Pongo abelii (Sumatran orangutan) - UXS1 gene Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). Indicus|evm.model.CM009508.1.457 Q8TCN5 ZN507_HUMAN 88.297 0.986528 1.01259 ZNF507 - Zinc finger protein 507 - Homo sapiens (Human) - ZNF507 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.458 Q6ZPD9 D19L3_HUMAN 92.318 0.997211 1.0014 DPY19L3 - Probable C-mannosyltransferase DPY19L3 - Homo sapiens (Human) - DPY19L3 gene Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Indicus|evm.model.CM009508.1.459 Q2HJH9 PDCD5_BOVIN 100.000 0.984127 1.008 PDCD5 - Programmed cell death protein 5 - Bos taurus (Bovine) - PDCD5 gene May function in the process of apoptosis. Indicus|evm.model.CM009508.1.460 Q96NW4 ANR27_HUMAN 88.762 0.998093 0.999048 ANKRD27 - Ankyrin repeat domain-containing protein 27 - Homo sapiens (Human) - ANKRD27 gene May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Indicus|evm.model.CM009508.1.461 Q8MJG0 R9BP_BOVIN 100.000 0.991597 1.00422 RGS9BP - Regulator of G-protein signaling 9-binding protein - Bos taurus (Bovine) - RGS9BP gene Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity). Indicus|evm.model.CM009508.1.462 A8MXV4 NUD19_HUMAN 70.681 0.994764 1.01867 NUDT19 - Nucleoside diphosphate-linked moiety X motif 19 - Homo sapiens (Human) - NUDT19 gene Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). Indicus|evm.model.CM009508.1.463 Q587J7 TDR12_HUMAN 80.961 0.870869 1.10535 TDRD12 - Putative ATP-dependent RNA helicase TDRD12 - Homo sapiens (Human) - TDRD12 gene Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. Indicus|evm.model.CM009508.1.464 P82251 BAT1_HUMAN 88.501 0.995902 1.00205 SLC7A9 - b(0,+)-type amino acid transporter 1 - Homo sapiens (Human) - SLC7A9 gene Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule. Indicus|evm.model.CM009508.1.465 Q96ST8 CEP89_HUMAN 75.325 0.996114 0.985951 CEP89 - Centrosomal protein of 89 kDa - Homo sapiens (Human) - CEP89 gene Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. Indicus|evm.model.CM009508.1.466 Q2KHY5 FAP24_BOVIN 100.000 0.990741 1.00465 FAAP24 - Fanconi anemia core complex-associated protein 24 - Bos taurus (Bovine) - FAAP24 gene Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA (By similarity). Indicus|evm.model.CM009508.1.467 A4FUC9 RHPN2_BOVIN 88.338 0.9968 0.911079 RHPN2 - Rhophilin-2 - Bos taurus (Bovine) - RHPN2 gene Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity). Indicus|evm.model.CM009508.1.468 Q24K12 GPTC1_BOVIN 99.678 0.997854 1.00107 GPATCH1 - G patch domain-containing protein 1 - Bos taurus (Bovine) - GPATCH1 gene Indicus|evm.model.CM009508.1.469 Q6ZMY6 WDR88_HUMAN 71.429 0.909836 1.0339 WDR88 - WD repeat-containing protein 88 - Homo sapiens (Human) - WDR88 gene Indicus|evm.model.CM009508.1.470 O75074 LRP3_HUMAN 90.909 0.97426 1.00909 LRP3 - Low-density lipoprotein receptor-related protein 3 precursor - Homo sapiens (Human) - LRP3 gene Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro. Indicus|evm.model.CM009508.1.471 P63116 AAA1_RAT 94.340 0.601831 1.64906 Slc7a10 - Asc-type amino acid transporter 1 - Rattus norvegicus (Rat) - Slc7a10 gene Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse (By similarity). Indicus|evm.model.CM009508.1.472 O02754 CEBPA_BOVIN 87.252 0.99435 1.00283 CEBPA - CCAAT/enhancer-binding protein alpha - Bos taurus (Bovine) - CEBPA gene Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung. Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage. To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex. In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites. Indicus|evm.model.CM009508.1.473 Q3T0B9 CEBPG_BOVIN 100.000 0.986667 1.00671 CEBPG - CCAAT/enhancer-binding protein gamma - Bos taurus (Bovine) - CEBPG gene Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. Indicus|evm.model.CM009508.1.474 P12955 PEPD_HUMAN 91.684 0.995951 1.00203 PEPD - Xaa-Pro dipeptidase - Homo sapiens (Human) - PEPD gene Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen. Indicus|evm.model.CM009508.1.476 Q9H2A9 CHST8_HUMAN 90.909 0.98209 0.790094 CHST8 - Carbohydrate sulfotransferase 8 - Homo sapiens (Human) - CHST8 gene Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. Indicus|evm.model.CM009508.1.478 Q0VD00 KCD15_BOVIN 100.000 0.992958 1.00353 KCTD15 - BTB/POZ domain-containing protein KCTD15 - Bos taurus (Bovine) - KCTD15 gene During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity). Indicus|evm.model.CM009508.1.479 Q3MHF8 LS14A_BOVIN 99.781 0.978495 1.00432 LSM14A - Protein LSM14 homolog A - Bos taurus (Bovine) - LSM14A gene Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly. Indicus|evm.model.CM009508.1.480 O15063 GRRE1_HUMAN 94.958 0.998134 1.00187 GARRE1 - Granule associated Rac and RHOG effector protein 1 - Homo sapiens (Human) - GARRE1 gene Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). Indicus|evm.model.CM009508.1.482 Q3ZBD7 G6PI_BOVIN 100.000 0.996416 1.0018 GPI - Glucose-6-phosphate isomerase - Bos taurus (Bovine) - GPI gene In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). Indicus|evm.model.CM009508.1.483 Q9BRP1 PDD2L_HUMAN 80.055 0.99455 1.02514 PDCD2L - Programmed cell death protein 2-like - Homo sapiens (Human) - PDCD2L gene Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. Indicus|evm.model.CM009508.1.484 Q9UBT2 SAE2_HUMAN 97.969 0.99688 1.00156 UBA2 - SUMO-activating enzyme subunit 2 - Homo sapiens (Human) - UBA2 gene The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Indicus|evm.model.CM009508.1.485 A6NIX2 WTIP_HUMAN 94.400 0.882979 0.655814 WTIP - Wilms tumor protein 1-interacting protein - Homo sapiens (Human) - WTIP gene Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Indicus|evm.model.CM009508.1.486 P30438 FEL1A_FELCA 49.275 0.581197 1.27174 CH1 - Major allergen I polypeptide chain 1 precursor - Felis catus (Cat) - CH1 gene extracellular region, steroid binding Indicus|evm.model.CM009508.1.487 Q0PGP2 ABP_MESAU 47.368 0.924731 0.808696 Androgen-binding protein homolog precursor - Mesocricetus auratus (Golden hamster) Indicus|evm.model.CM009508.1.488 Q61187 TS101_MOUSE 87.179 0.870787 0.455243 Tsg101 - Tumor susceptibility gene 101 protein - Mus musculus (Mouse) - Tsg101 gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity). Indicus|evm.model.CM009508.1.489 Q6UGQ3 SG2B2_MOUSE 50.000 0.537975 1.38596 Scgb2b2 - Secretoglobin family 2B member 2 precursor - Mus musculus (Mouse) - Scgb2b2 gene Indicus|evm.model.CM009508.1.490 P30438 FEL1A_FELCA 51.471 0.443709 1.6413 CH1 - Major allergen I polypeptide chain 1 precursor - Felis catus (Cat) - CH1 gene extracellular region, steroid binding Indicus|evm.model.CM009508.1.491 P30438 FEL1A_FELCA 52.941 0.531746 1.36957 CH1 - Major allergen I polypeptide chain 1 precursor - Felis catus (Cat) - CH1 gene extracellular region, steroid binding Indicus|evm.model.CM009508.1.493 P30438 FEL1A_FELCA 52.941 0.57265 1.27174 CH1 - Major allergen I polypeptide chain 1 precursor - Felis catus (Cat) - CH1 gene extracellular region, steroid binding Indicus|evm.model.CM009508.1.494 Q2KI58 ZN181_BOVIN 99.825 0.831871 1.2 ZNF181 - Zinc finger protein 181 - Bos taurus (Bovine) - ZNF181 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.495 Q96NL3 ZN599_HUMAN 84.694 0.996604 1.0017 ZNF599 - Zinc finger protein 599 - Homo sapiens (Human) - ZNF599 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.496 Q7Z398 ZN550_HUMAN 71.831 0.380435 0.436019 ZNF550 - Zinc finger protein 550 - Homo sapiens (Human) - ZNF550 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.498 Q8CFC4 BGAT2_RAT 51.613 0.836283 0.676647 Abo2 - Histo-blood group ABO system transferase 2 - Rattus norvegicus (Rat) - Abo2 gene Posseses strong B transferase activity and a weak A transferase activity. Indicus|evm.model.CM009508.1.499 Q3KQV3 ZN792_HUMAN 62.401 0.991364 0.916139 ZNF792 - Zinc finger protein 792 - Homo sapiens (Human) - ZNF792 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.500 P0DP31 CALM3_RAT 95.973 0.986667 1.00671 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Indicus|evm.model.CM009508.1.501 Q96CP6 ASTRA_HUMAN 95.839 0.83939 1.17818 GRAMD1A - Protein Aster-A - Homo sapiens (Human) - GRAMD1A gene Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). Indicus|evm.model.CM009508.1.502 Q17QN4 SCN1B_BOVIN 100.000 0.990868 1.00459 SCN1B - Sodium channel subunit beta-1 precursor - Bos taurus (Bovine) - SCN1B gene Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. Indicus|evm.model.CM009508.1.503 P05981 HEPS_HUMAN 93.525 0.995215 1.0024 HPN - Serine protease hepsin - Homo sapiens (Human) - HPN gene Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890). Indicus|evm.model.CM009508.1.505 P59645 FXYD3_RAT 89.855 0.8 0.965909 Fxyd3 - FXYD domain-containing ion transport regulator 3 precursor - Rattus norvegicus (Rat) - Fxyd3 gene Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. Indicus|evm.model.CM009508.1.506 Q8N135 LGI4_HUMAN 92.471 0.959184 1.00372 LGI4 - Leucine-rich repeat LGI family member 4 precursor - Homo sapiens (Human) - LGI4 gene Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity). Indicus|evm.model.CM009508.1.507 W5P3P0 PLM_SHEEP 100.000 0.442105 2.06522 FXYD1 - Phospholemman precursor - Ovis aries (Sheep) - FXYD1 gene Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Indicus|evm.model.CM009508.1.508 I3LMB3 PLM_PIG 52.632 0.212644 2 FXYD1 - Phospholemman precursor - Sus scrofa (Pig) - FXYD1 gene Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Indicus|evm.model.CM009508.1.509 Q17R55 F187B_HUMAN 56.640 0.994536 0.99187 FAM187B - Protein FAM187B precursor - Homo sapiens (Human) - FAM187B gene Indicus|evm.model.CM009508.1.510 Q0VAY3 F187B_MOUSE 56.723 0.991632 0.667598 Fam187b - Protein FAM187B precursor - Mus musculus (Mouse) - Fam187b gene Indicus|evm.model.CM009508.1.511 Q86X29 LSR_HUMAN 85.177 0.973856 0.707242 LSR - Lipolysis-stimulated lipoprotein receptor - Homo sapiens (Human) - LSR gene Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Indicus|evm.model.CM009508.1.512 Q63665 USF2_RAT 97.846 0.920455 1.01734 Usf2 - Upstream stimulatory factor 2 - Rattus norvegicus (Rat) - Usf2 gene Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Indicus|evm.model.CM009508.1.513 Q8MJ80 HEPC_PIG 79.592 0.827586 0.707317 HAMP - Hepcidin precursor - Sus scrofa (Pig) - HAMP gene Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Indicus|evm.model.CM009508.1.514 P20916 MAG_HUMAN 94.409 0.99681 1.0016 MAG - Myelin-associated glycoprotein precursor - Homo sapiens (Human) - MAG gene Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity). Indicus|evm.model.CM009508.1.515 Q9WU74 LSR_RAT 89.844 0.47037 0.455312 Lsr - Lipolysis-stimulated lipoprotein receptor precursor - Rattus norvegicus (Rat) - Lsr gene Probable role in the clearance of triglyceride-rich lipoprotein from plasma. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells. Indicus|evm.model.CM009508.1.516 P20273 CD22_HUMAN 58.473 0.981043 0.996458 CD22 - B-cell receptor CD22 precursor - Homo sapiens (Human) - CD22 gene Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Indicus|evm.model.CM009508.1.517 O14842 FFAR1_HUMAN 84.333 0.993355 1.00333 FFAR1 - Free fatty acid receptor 1 - Homo sapiens (Human) - FFAR1 gene G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. Indicus|evm.model.CM009508.1.518 O14843 FFAR3_HUMAN 79.808 0.859116 1.04624 FFAR3 - Free fatty acid receptor 3 - Homo sapiens (Human) - FFAR3 gene G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604). Indicus|evm.model.CM009508.1.519 Q8VCK6 FFAR2_MOUSE 55.517 0.886598 0.881818 Ffar2 - Free fatty acid receptor 2 - Mus musculus (Mouse) - Ffar2 gene G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine (PubMed:22190648, PubMed:23589301). May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake (PubMed:20399779). Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes (PubMed:16123168, PubMed:23589301). In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines (PubMed:23665276). May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils (PubMed:19917676, PubMed:19865172). In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes. Indicus|evm.model.CM009508.1.520 O15552 FFAR2_HUMAN 76.900 0.993939 1 FFAR2 - Free fatty acid receptor 2 - Homo sapiens (Human) - FFAR2 gene G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604). Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016). Indicus|evm.model.CM009508.1.521 Q52MQ7 KTDAP_CANLF 92.929 0.98 1.0101 KRTDAP - Keratinocyte differentiation-associated protein precursor - Canis lupus familiaris (Dog) - KRTDAP gene May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity). Indicus|evm.model.CM009508.1.522 A6QQF6 SBSN_BOVIN 99.282 0.996416 1.0018 SBSN - Suprabasin precursor - Bos taurus (Bovine) - SBSN gene Indicus|evm.model.CM009508.1.523 Q2KJE5 G3PT_BOVIN 97.767 0.550685 1.8481 GAPDHS - Glyceraldehyde-3-phosphate dehydrogenase, testis-specific - Bos taurus (Bovine) - GAPDHS gene May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity). Indicus|evm.model.CM009508.1.524 I6VSD2 TM147_CAPHI 100.000 0.991111 1.00446 TMEM147 - Transmembrane protein 147 - Capra hircus (Goat) - TMEM147 gene Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Together with SEC61 and TMCO1, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity. Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Indicus|evm.model.CM009508.1.525 P19156 ATP4A_PIG 99.122 0.992722 0.66441 ATP4A - Potassium-transporting ATPase alpha chain 1 - Sus scrofa (Pig) - ATP4A gene The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (PubMed:29618813, PubMed:31436534, PubMed:30143663, PubMed:19387495). Indicus|evm.model.CM009508.1.526 P19156 ATP4A_PIG 99.582 0.955823 0.240812 ATP4A - Potassium-transporting ATPase alpha chain 1 - Sus scrofa (Pig) - ATP4A gene The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (PubMed:29618813, PubMed:31436534, PubMed:30143663, PubMed:19387495). Indicus|evm.model.CM009508.1.527 Q45FY6 HPRT_PIG 68.912 0.476923 1.49083 HPRT1 - Hypoxanthine-guanine phosphoribosyltransferase - Sus scrofa (Pig) - HPRT1 gene Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). Indicus|evm.model.CM009508.1.528 A7YY46 PNKD_BOVIN 80.198 0.699301 0.371429 PNKD - Probable hydrolase PNKD - Bos taurus (Bovine) - PNKD gene Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. Indicus|evm.model.CM009508.1.529 O94927 HAUS5_HUMAN 80.854 0.995268 1.00158 HAUS5 - HAUS augmin-like complex subunit 5 - Homo sapiens (Human) - HAUS5 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Indicus|evm.model.CM009508.1.530 Q9BTD8 RBM42_HUMAN 98.125 0.995816 0.995833 RBM42 - RNA-binding protein 42 - Homo sapiens (Human) - RBM42 gene Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. Indicus|evm.model.CM009508.1.531 O00321 ETV2_HUMAN 67.241 0.9941 0.991228 ETV2 - ETS translocation variant 2 - Homo sapiens (Human) - ETV2 gene Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. Indicus|evm.model.CM009508.1.532 P38572 UPK1A_BOVIN 99.225 0.529897 1.87984 UPK1A - Uroplakin-1a - Bos taurus (Bovine) - UPK1A gene Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. Indicus|evm.model.CM009508.1.533 Q9UMN6 KMT2B_HUMAN 90.554 0.824311 1.16354 KMT2B - Histone-lysine N-methyltransferase 2B - Homo sapiens (Human) - KMT2B gene Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:17707229). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:17707229). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). Indicus|evm.model.CM009508.1.534 A5PJC7 IGFR1_BOVIN 98.883 0.899244 1.11204 IGFLR1 - IGF-like family receptor 1 precursor - Bos taurus (Bovine) - IGFLR1 gene Probable cell membrane receptor for the IGF-like family protein IGFL. Indicus|evm.model.CM009508.1.535 Q3T127 U2AF4_BOVIN 100.000 0.908714 1.09545 U2AF1L4 - Splicing factor U2AF 26 kDa subunit - Bos taurus (Bovine) - U2AF1L4 gene RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). Indicus|evm.model.CM009508.1.536 Q5G235 PEN2_BOVIN 100.000 0.980392 1.0099 PSENEN - Gamma-secretase subunit PEN-2 - Bos taurus (Bovine) - PSENEN gene Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. Indicus|evm.model.CM009508.1.537 Q1RMQ5 LIN37_BOVIN 100.000 0.991903 1.00407 LIN37 - Protein lin-37 homolog - Bos taurus (Bovine) - LIN37 gene Myb complex, negative regulation of transcription by RNA polymerase II Indicus|evm.model.CM009508.1.538 Q148F8 HSPB6_BOVIN 99.390 0.987879 1.0061 HSPB6 - Heat shock protein beta-6 - Bos taurus (Bovine) - HSPB6 gene Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. Indicus|evm.model.CM009508.1.539 Q2NL68 PRSR3_HUMAN 75.352 0.435055 1.33125 PROSER3 - Proline and serine-rich protein 3 - Homo sapiens (Human) - PROSER3 gene Indicus|evm.model.CM009508.1.540 O14559 RHG33_HUMAN 91.022 0.998415 0.980575 ARHGAP33 - Rho GTPase-activating protein 33 - Homo sapiens (Human) - ARHGAP33 gene May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). Indicus|evm.model.CM009508.1.542 A6QQ74 HYPDH_BOVIN 98.482 0.268849 3.7115 PRODH2 - Hydroxyproline dehydrogenase - Bos taurus (Bovine) - PRODH2 gene Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis. Indicus|evm.model.CM009508.1.543 Q6UWL6 KIRR2_HUMAN 87.977 0.864699 1.14831 KIRREL2 - Kin of IRRE-like protein 2 precursor - Homo sapiens (Human) - KIRREL2 gene May regulate basal insulin secretion. Indicus|evm.model.CM009508.1.544 P51693 APLP1_HUMAN 90.015 0.99689 0.989231 APLP1 - Amyloid-like protein 1 precursor - Homo sapiens (Human) - APLP1 gene May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. Indicus|evm.model.CM009508.1.545 Q95J79 TYOBP_BOVIN 91.463 0.153992 4.87037 TYROBP - TYRO protein tyrosine kinase-binding protein precursor - Bos taurus (Bovine) - TYROBP gene Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity). Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity). Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (By similarity). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes proinflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). Positively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allosimulatory ability (By similarity). Negatively regulates B cell proliferation (By similarity). Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity). Indicus|evm.model.CM009508.1.546 Q1RMS4 LRFN3_BOVIN 100.000 0.99682 1.00159 LRFN3 - Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor - Bos taurus (Bovine) - LRFN3 gene Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity). Indicus|evm.model.CM009508.1.548 A8PU71 SDHF1_BOVIN 100.000 0.983193 1.00847 SDHAF1 - Succinate dehydrogenase assembly factor 1, mitochondrial - Bos taurus (Bovine) - SDHAF1 gene Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Indicus|evm.model.CM009508.1.549 Q3KRA9 ALKB6_HUMAN 93.697 0.388525 2.56303 ALKBH6 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 - Homo sapiens (Human) - ALKBH6 gene Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. Indicus|evm.model.CM009508.1.550 Q96DZ5 CLIP3_HUMAN 98.172 0.99635 1.00183 CLIP3 - CAP-Gly domain-containing linker protein 3 - Homo sapiens (Human) - CLIP3 gene Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. Indicus|evm.model.CM009508.1.551 Q8NA92 THAP8_HUMAN 77.863 0.472868 0.941606 THAP8 - THAP domain-containing protein 8 - Homo sapiens (Human) - THAP8 gene Indicus|evm.model.CM009508.1.552 D3YYM0 OVOL3_MOUSE 90.977 0.078478 8.89947 Ovol3 - Putative transcription factor ovo-like protein 3 - Mus musculus (Mouse) - Ovol3 gene May act as a transcription regulator. Indicus|evm.model.CM009508.1.553 P60899 RPB9_PIG 100.000 0.984127 1.008 POLR2I - DNA-directed RNA polymerase II subunit RPB9 - Sus scrofa (Pig) - POLR2I gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). Indicus|evm.model.CM009508.1.554 Q5E951 TBCB_BOVIN 99.590 0.991837 1.0041 TBCB - Tubulin-folding cofactor B - Bos taurus (Bovine) - TBCB gene Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. Indicus|evm.model.CM009508.1.555 P13135 CPNS1_BOVIN 100.000 0.992424 1.0038 CAPNS1 - Calpain small subunit 1 - Bos taurus (Bovine) - CAPNS1 gene Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Indicus|evm.model.CM009508.1.556 P07470 CX7A1_BOVIN 98.750 0.975309 1.0125 COX7A1 - Cytochrome c oxidase subunit 7A1, mitochondrial precursor - Bos taurus (Bovine) - COX7A1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009508.1.557 Q8N9K5 ZN565_HUMAN 88.337 0.913121 1.04638 ZNF565 - Zinc finger protein 565 - Homo sapiens (Human) - ZNF565 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.558 Q28151 OZF_BOVIN 99.658 0.993174 1.00342 ZNF146 - Zinc finger protein OZF - Bos taurus (Bovine) - ZNF146 gene Indicus|evm.model.CM009508.1.559 A2VDP4 ZN567_BOVIN 99.536 0.996914 1.00155 ZNF567 - Zinc finger protein 567 - Bos taurus (Bovine) - ZNF567 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.560 Q8TAF7 ZN461_HUMAN 77.403 0.59472 1.14387 ZNF461 - Zinc finger protein 461 - Homo sapiens (Human) - ZNF461 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.561 Q96SR6 ZN382_HUMAN 88.385 0.994575 1.00545 ZNF382 - Zinc finger protein 382 - Homo sapiens (Human) - ZNF382 gene Functions as a sequence-specific transcriptional repressor. Indicus|evm.model.CM009508.1.562 Q6P280 ZN529_HUMAN 79.691 0.996124 0.916519 ZNF529 - Zinc finger protein 529 - Homo sapiens (Human) - ZNF529 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.563 Q3ZCT1 ZN260_HUMAN 91.748 0.995146 1 ZNF260 - Zinc finger protein 260 - Homo sapiens (Human) - ZNF260 gene Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity). Indicus|evm.model.CM009508.1.564 Q6J6I6 ZN566_PANTR 89.286 0.995249 1.00718 ZNF566 - Zinc finger protein 566 - Pan troglodytes (Chimpanzee) - ZNF566 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.565 Q8N141 ZFP82_HUMAN 91.165 0.996219 0.994361 ZFP82 - Zinc finger protein 82 homolog - Homo sapiens (Human) - ZFP82 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.566 Q9HCL3 ZFP14_HUMAN 93.996 0.996248 1 ZFP14 - Zinc finger protein 14 homolog - Homo sapiens (Human) - ZFP14 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.567 Q3ZCX4 ZN568_HUMAN 79.787 0.638225 0.454969 ZNF568 - Zinc finger protein 568 - Homo sapiens (Human) - ZNF568 gene Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells. Indicus|evm.model.CM009508.1.569 Q6P3V2 Z585A_HUMAN 91.964 0.763367 1.14304 ZNF585A - Zinc finger protein 585A - Homo sapiens (Human) - ZNF585A gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.570 Q8NA42 ZN383_HUMAN 93.474 0.995789 1 ZNF383 - Zinc finger protein 383 - Homo sapiens (Human) - ZNF383 gene May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways. Indicus|evm.model.CM009508.1.571 Q3ZCX4 ZN568_HUMAN 49.196 0.713626 0.67236 ZNF568 - Zinc finger protein 568 - Homo sapiens (Human) - ZNF568 gene Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells. Indicus|evm.model.CM009508.1.572 P10072 ZN875_HUMAN 63.944 0.807692 0.591806 ZNF875 - Zinc finger protein 875 - Homo sapiens (Human) - ZNF875 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.573 Q8NB42 ZN527_HUMAN 87.192 0.996721 1.00164 ZNF527 - Zinc finger protein 527 - Homo sapiens (Human) - ZNF527 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.574 Q5MCW4 ZN569_HUMAN 91.545 0.997085 1 ZNF569 - Zinc finger protein 569 - Homo sapiens (Human) - ZNF569 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.575 Q96NI8 ZN570_HUMAN 90.503 0.996276 1.00187 ZNF570 - Zinc finger protein 570 - Homo sapiens (Human) - ZNF570 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.576 A2VDQ7 ZN420_BOVIN 99.709 0.997093 1.00146 ZNF420 - Zinc finger protein 420 - Bos taurus (Bovine) - ZNF420 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.580 Q9Y2G7 ZFP30_HUMAN 89.869 0.994393 1.03083 ZFP30 - Zinc finger protein 30 homolog - Homo sapiens (Human) - ZFP30 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.581 Q8NA42 ZN383_HUMAN 66.540 0.491557 1.12211 ZNF383 - Zinc finger protein 383 - Homo sapiens (Human) - ZNF383 gene May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways. Indicus|evm.model.CM009508.1.582 Q6ZQQ6 WDR87_HUMAN 57.877 0.0985117 0.982249 WDR87 - WD repeat-containing protein 87 - Homo sapiens (Human) - WDR87 gene Indicus|evm.model.CM009508.1.583 Q6ZQQ6 WDR87_HUMAN 68.910 0.99537 0.150365 WDR87 - WD repeat-containing protein 87 - Homo sapiens (Human) - WDR87 gene Indicus|evm.model.CM009508.1.584 Q6ZQQ6 WDR87_HUMAN 60.756 0.899139 0.848938 WDR87 - WD repeat-containing protein 87 - Homo sapiens (Human) - WDR87 gene Indicus|evm.model.CM009508.1.585 O60292 SI1L3_HUMAN 91.173 0.998872 0.995508 SIPA1L3 - Signal-induced proliferation-associated 1-like protein 3 - Homo sapiens (Human) - SIPA1L3 gene Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). Indicus|evm.model.CM009508.1.586 P56163 DPF1_RAT 90.777 0.934091 1.10831 Dpf1 - Zinc finger protein neuro-d4 - Rattus norvegicus (Rat) - Dpf1 gene May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Indicus|evm.model.CM009508.1.587 O18734 PP14A_PIG 97.260 0.97973 1.0068 CPI17 - Protein phosphatase 1 regulatory subunit 14A - Sus scrofa (Pig) - CPI17 gene Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Indicus|evm.model.CM009508.1.588 O43291 SPIT2_HUMAN 74.206 0.992032 0.996032 SPINT2 - Kunitz-type protease inhibitor 2 precursor - Homo sapiens (Human) - SPINT2 gene Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. Indicus|evm.model.CM009508.1.590 Q5BJH7 YIF1B_HUMAN 92.715 0.96129 0.987261 YIF1B - Protein YIF1B - Homo sapiens (Human) - YIF1B gene Involved in the anterograde traffic pathway from the endoplasmic reticulum to the plasma membrane and the organization of the Golgi architecture (By similarity). Plays a key role in targeting to neuronal dendrites receptors such as HTR1A (By similarity). Indicus|evm.model.CM009508.1.591 Q9Y257 KCNK6_HUMAN 88.179 0.99361 1 KCNK6 - Potassium channel subfamily K member 6 - Homo sapiens (Human) - KCNK6 gene Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions. Indicus|evm.model.CM009508.1.592 Q6ZRH7 CTSRG_HUMAN 72.483 0.997389 0.991372 CATSPERG - Cation channel sperm-associated protein subunit gamma precursor - Homo sapiens (Human) - CATSPERG gene Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Indicus|evm.model.CM009508.1.593 Q3SYT7 PSMD8_BOVIN 99.303 0.993056 1.00348 PSMD8 - 26S proteasome non-ATPase regulatory subunit 8 - Bos taurus (Bovine) - PSMD8 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Indicus|evm.model.CM009508.1.594 Q66HC8 GGN_RAT 73.785 0.997033 1.02432 Ggn - Gametogenetin - Rattus norvegicus (Rat) - Ggn gene May be involved in spermatogenesis. Indicus|evm.model.CM009508.1.595 Q2MJR0 SPRE3_HUMAN 96.396 0.499248 1.62195 SPRED3 - Sprouty-related, EVH1 domain-containing protein 3 - Homo sapiens (Human) - SPRED3 gene Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Indicus|evm.model.CM009508.1.596 Q1LZ97 GRP4_BOVIN 98.420 0.996845 0.942051 RASGRP4 - RAS guanyl-releasing protein 4 - Bos taurus (Bovine) - RASGRP4 gene Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation (By similarity). Indicus|evm.model.CM009508.1.597 P16960 RYR1_PIG 98.240 0.845742 1.0004 RYR1 - Ryanodine receptor 1 - Sus scrofa (Pig) - RYR1 gene Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (By similarity). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). Indicus|evm.model.CM009508.1.598 Q92918 M4K1_HUMAN 92.509 0.973203 0.985594 MAP4K1 - Mitogen-activated protein kinase kinase kinase kinase 1 - Homo sapiens (Human) - MAP4K1 gene Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). Indicus|evm.model.CM009508.1.599 Q3T0V3 EIF3K_BOVIN 100.000 0.990868 1.00459 EIF3K - Eukaryotic translation initiation factor 3 subunit K - Bos taurus (Bovine) - EIF3K gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Indicus|evm.model.CM009508.1.600 A5D7D1 ACTN4_BOVIN 99.661 0.99774 0.97146 ACTN4 - Alpha-actinin-4 - Bos taurus (Bovine) - ACTN4 gene F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA. Indicus|evm.model.CM009508.1.601 Q6ZSI9 CAN12_HUMAN 83.657 0.99723 1.00417 CAPN12 - Calpain-12 - Homo sapiens (Human) - CAPN12 gene Calcium-regulated non-lysosomal thiol-protease. Indicus|evm.model.CM009508.1.602 O54974 LEG7_MOUSE 76.336 0.928571 1.02941 Lgals7 - Galectin-7 - Mus musculus (Mouse) - Lgals7 gene Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity). Indicus|evm.model.CM009508.1.603 Q2KJD3 CWC15_BOVIN 93.182 0.747826 0.497835 CWC15 - Spliceosome-associated protein CWC15 homolog - Bos taurus (Bovine) - CWC15 gene Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Indicus|evm.model.CM009508.1.604 O54974 LEG7_MOUSE 74.809 0.928571 1.02941 Lgals7 - Galectin-7 - Mus musculus (Mouse) - Lgals7 gene Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity). Indicus|evm.model.CM009508.1.605 Q3T0D6 LEG4_BOVIN 98.193 0.993994 1.00301 LGALS4 - Galectin-4 - Bos taurus (Bovine) - LGALS4 gene Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions (By similarity). Indicus|evm.model.CM009508.1.606 Q5RFG0 ECH1_PONAB 80.464 0.920489 0.996951 ECH1 - Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - ECH1 gene Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. Indicus|evm.model.CM009508.1.607 P14866 HNRPL_HUMAN 98.132 0.996564 0.988115 HNRNPL - Heterogeneous nuclear ribonucleoprotein L - Homo sapiens (Human) - HNRNPL gene Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). Indicus|evm.model.CM009508.1.608 Q6ZS11 RINL_HUMAN 73.451 0.992895 0.9947 RINL - Ras and Rab interactor-like protein - Homo sapiens (Human) - RINL gene Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity). Indicus|evm.model.CM009508.1.609 Q5RJQ4 SIR2_RAT 89.174 0.895141 1.11714 Sirt2 - NAD-dependent protein deacetylase sirtuin-2 - Rattus norvegicus (Rat) - Sirt2 gene NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:17344398). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response. Deacetylates also histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition. During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis. Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells. Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity. Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells. Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy (By similarity). Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation (By similarity). Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Deacetylates also EIF5A. Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor (By similarity). Indicus|evm.model.CM009508.1.610 Q15653 IKBB_HUMAN 86.034 0.991643 1.00843 NFKBIB - NF-kappa-B inhibitor beta - Homo sapiens (Human) - NFKBIB gene Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. Indicus|evm.model.CM009508.1.611 I3L3R5 CCER2_HUMAN 68.487 0.865169 1.00376 CCER2 - Coiled-coil domain-containing glutamate-rich protein 2 precursor - Homo sapiens (Human) - CCER2 gene Indicus|evm.model.CM009508.1.612 Q9N0F3 SYSM_BOVIN 99.421 0.996146 1.00193 SARS2 - Serine--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - SARS2 gene Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). Indicus|evm.model.CM009508.1.613 Q29RU1 RT12_BOVIN 100.000 0.985714 1.00719 MRPS12 - 28S ribosomal protein S12, mitochondrial precursor - Bos taurus (Bovine) - MRPS12 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, ribosome, structural constituent of ribosome, mitochondrial translation, translation Indicus|evm.model.CM009508.1.614 Q96EF6 FBX17_HUMAN 80.287 0.992857 1.00719 FBXO17 - F-box only protein 17 - Homo sapiens (Human) - FBXO17 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins. Indicus|evm.model.CM009508.1.615 Q8NI29 FBX27_HUMAN 51.163 0.898917 0.978799 FBXO27 - F-box only protein 27 - Homo sapiens (Human) - FBXO27 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Indicus|evm.model.CM009508.1.616 Q9N0C8 FBX27_MACFA 53.571 0.107404 3.425 FBXO27 - F-box only protein 27 - Macaca fascicularis (Crab-eating macaque) - FBXO27 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides. Indicus|evm.model.CM009508.1.617 Q8NI29 FBX27_HUMAN 49.466 0.916968 0.978799 FBXO27 - F-box only protein 27 - Homo sapiens (Human) - FBXO27 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Indicus|evm.model.CM009508.1.618 Q5R8M9 RS19_PONAB 98.592 0.972222 0.496552 RPS19 - 40S ribosomal protein S19 - Pongo abelii (Sumatran orangutan) - RPS19 gene Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Indicus|evm.model.CM009508.1.619 Q6ZNF0 ACP7_HUMAN 90.955 0.97543 0.929224 ACP7 - Acid phosphatase type 7 precursor - Homo sapiens (Human) - ACP7 gene Indicus|evm.model.CM009508.1.620 O96013 PAK4_HUMAN 92.941 0.996633 1.00508 PAK4 - Serine/threonine-protein kinase PAK 4 - Homo sapiens (Human) - PAK4 gene Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Indicus|evm.model.CM009508.1.621 Q6ZVX7 FBX50_HUMAN 80.364 0.992337 0.949091 NCCRP1 - F-box only protein 50 - Homo sapiens (Human) - NCCRP1 gene Promotes cell proliferation. Indicus|evm.model.CM009508.1.622 Q0VAF6 SYCN_HUMAN 77.444 0.862745 1.14179 SYCN - Syncollin precursor - Homo sapiens (Human) - SYCN gene Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity). Indicus|evm.model.CM009508.1.623 Q8IZI9 IFNL3_HUMAN 68.783 0.943878 1 IFNL3 - Interferon lambda-3 precursor - Homo sapiens (Human) - IFNL3 gene Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. Indicus|evm.model.CM009508.1.624 K9M1U5 IFNL4_HUMAN 68.156 0.956989 1.03911 IFNL4 - Interferon lambda-4 precursor - Homo sapiens (Human) - IFNL4 gene Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes. Indicus|evm.model.CM009508.1.625 K9M1U5 IFNL4_HUMAN 67.442 0.876712 0.815642 IFNL4 - Interferon lambda-4 precursor - Homo sapiens (Human) - IFNL4 gene Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes. Indicus|evm.model.CM009508.1.626 Q8IZJ0 IFNL2_HUMAN 66.129 0.406667 0.75 IFNL2 - Interferon lambda-2 precursor - Homo sapiens (Human) - IFNL2 gene Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. Indicus|evm.model.CM009508.1.627 Q2WF71 LRFN1_MOUSE 95.325 0.997406 1.00653 Lrfn1 - Leucine-rich repeat and fibronectin type III domain-containing protein 1 precursor - Mus musculus (Mouse) - Lrfn1 gene Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1. Indicus|evm.model.CM009508.1.628 Q56JZ9 GMFG_BOVIN 100.000 0.679612 1.4507 GMFG - Glia maturation factor gamma - Bos taurus (Bovine) - GMFG gene Arp2/3 complex binding, actin filament debranching, negative regulation of Arp2/3 complex-mediated actin nucleation Indicus|evm.model.CM009508.1.630 Q5PRF9 SMAG2_HUMAN 97.285 0.92827 0.341499 SAMD4B - Protein Smaug homolog 2 - Homo sapiens (Human) - SAMD4B gene Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. Indicus|evm.model.CM009508.1.631 Q4V886 PAF1_RAT 100.000 0.987952 0.620561 Paf1 - RNA polymerase II-associated factor 1 homolog - Rattus norvegicus (Rat) - Paf1 gene Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors (By similarity). Indicus|evm.model.CM009508.1.632 A1A4Q8 MED29_BOVIN 100.000 0.99005 1.005 MED29 - Mediator of RNA polymerase II transcription subunit 29 - Bos taurus (Bovine) - MED29 gene Component of the mediator complex, a complex that can either repress or activate transcription. Mediator complexes are essential for basal and regulated expression of nearly all RNA polymerase II-dependent genes. They may act as a bridge, conveying regulatory information from enhancers and other control elements to the promoter (By similarity). Indicus|evm.model.CM009508.1.633 Q5PRF9 SMAG2_HUMAN 96.829 0.981289 0.693084 SAMD4B - Protein Smaug homolog 2 - Homo sapiens (Human) - SAMD4B gene Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. Indicus|evm.model.CM009508.1.634 Q9H7P9 PKHG2_HUMAN 74.756 0.998596 1.02742 PLEKHG2 - Pleckstrin homology domain-containing family G member 2 - Homo sapiens (Human) - PLEKHG2 gene May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). Indicus|evm.model.CM009508.1.635 P62250 RS16_RAT 100.000 0.986395 1.00685 Rps16 - 40S ribosomal protein S16 - Rattus norvegicus (Rat) - Rps16 gene cytosolic small ribosomal subunit, small ribosomal subunit, RNA binding, structural constituent of ribosome, cellular response to leukemia inhibitory factor, liver regeneration, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit biogenesis, rRNA processing, translation Indicus|evm.model.CM009508.1.636 Q5R405 SPT5H_PONAB 95.383 0.998075 0.959372 SUPT5H - Transcription elongation factor SPT5 - Pongo abelii (Sumatran orangutan) - SUPT5H gene Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity). Indicus|evm.model.CM009508.1.637 Q3SZB3 TIM50_BOVIN 99.718 0.994382 1.00282 TIMM50 - Mitochondrial import inner membrane translocase subunit TIM50 precursor - Bos taurus (Bovine) - TIMM50 gene Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Indicus|evm.model.CM009508.1.638 Q9NYJ7 DLL3_HUMAN 89.228 0.994633 0.904531 DLL3 - Delta-like protein 3 precursor - Homo sapiens (Human) - DLL3 gene Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). Indicus|evm.model.CM009508.1.640 Q17QW4 EID2_BOVIN 100.000 0.990909 1.00457 EID2 - EP300-interacting inhibitor of differentiation 2 - Bos taurus (Bovine) - EID2 gene Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex (By similarity). Indicus|evm.model.CM009508.1.641 Q8TCE9 PPL13_HUMAN 47.328 0.928571 1.00719 LGALS14 - Placental protein 13-like - Homo sapiens (Human) - LGALS14 gene Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Indicus|evm.model.CM009508.1.642 A8MUM7 LEG16_HUMAN 48.148 0.964029 0.978873 LGALS16 - Galectin-16 - Homo sapiens (Human) - LGALS16 gene Binds lactose with high affinity. Strong inducer of T-cell apoptosis. Indicus|evm.model.CM009508.1.643 Q9Y463 DYR1B_HUMAN 98.728 0.911466 1.09539 DYRK1B - Dual specificity tyrosine-phosphorylation-regulated kinase 1B - Homo sapiens (Human) - DYRK1B gene Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). Indicus|evm.model.CM009508.1.644 P22087 FBRL_HUMAN 98.077 0.81962 0.984424 FBL - rRNA 2'-O-methyltransferase fibrillarin - Homo sapiens (Human) - FBL gene S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:24352239, PubMed:30540930, PubMed:32017898). Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:30540930). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239, PubMed:30540930). Indicus|evm.model.CM009508.1.645 Q5RET3 AAGAB_PONAB 82.888 0.798283 0.739683 AAGAB - Alpha- and gamma-adaptin-binding protein p34 - Pongo abelii (Sumatran orangutan) - AAGAB gene May be involved in endocytic recycling of growth factor receptors such as EGFR. Indicus|evm.model.CM009508.1.646 Q4R7L3 PRS6B_MACFA 100.000 0.995227 1.00239 PSMC4 - 26S proteasome regulatory subunit 6B - Macaca fascicularis (Crab-eating macaque) - PSMC4 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Indicus|evm.model.CM009508.1.647 Q9Y6R7 FCGBP_HUMAN 70.384 0.932542 0.592414 FCGBP - IgGFc-binding protein precursor - Homo sapiens (Human) - FCGBP gene May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa. Indicus|evm.model.CM009508.1.648 Q02779 M3K10_HUMAN 97.912 0.706056 0.709644 MAP3K10 - Mitogen-activated protein kinase kinase kinase 10 - Homo sapiens (Human) - MAP3K10 gene Activates the JUN N-terminal pathway. Indicus|evm.model.CM009508.1.649 Q8N6N2 TTC9B_HUMAN 92.050 0.991525 0.987448 TTC9B - Tetratricopeptide repeat protein 9B - Homo sapiens (Human) - TTC9B gene Indicus|evm.model.CM009508.1.650 Q9H8S5 CCNP_HUMAN 81.496 0.81877 1.00651 CCNP - Cyclin-P - Homo sapiens (Human) - CCNP gene Seems to be involved in the regulation of proliferation and migration. Indicus|evm.model.CM009508.1.651 P31751 AKT2_HUMAN 98.753 0.995851 1.00208 AKT2 - RAC-beta serine/threonine-protein kinase - Homo sapiens (Human) - AKT2 gene AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Indicus|evm.model.CM009508.1.652 Q8N9M1 CS047_HUMAN 91.471 0.911051 0.879147 C19orf47 - Uncharacterized protein C19orf47 - Homo sapiens (Human) - C19orf47 gene nucleoplasm, nucleus Indicus|evm.model.CM009508.1.653 Q2KJJ8 PLD3_BOVIN 100.000 0.995927 1.00204 PLD3 - 5'-3' exonuclease PLD3 - Bos taurus (Bovine) - PLD3 gene 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). Indicus|evm.model.CM009508.1.654 Q8WP28 HIPK4_MACFA 88.493 0.996759 1.00162 HIPK4 - Homeodomain-interacting protein kinase 4 - Macaca fascicularis (Crab-eating macaque) - HIPK4 gene Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). Indicus|evm.model.CM009508.1.655 E1BM58 PRAX_BOVIN 99.926 0.905306 1.10378 PRX - Periaxin - Bos taurus (Bovine) - PRX gene Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology. Indicus|evm.model.CM009508.1.656 Q9UHV2 SRTD1_HUMAN 89.873 0.987448 1.01271 SERTAD1 - SERTA domain-containing protein 1 - Homo sapiens (Human) - SERTAD1 gene Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A. Indicus|evm.model.CM009508.1.657 Q9UJW9 SRTD3_HUMAN 91.414 0.732342 1.37245 SERTAD3 - SERTA domain-containing protein 3 - Homo sapiens (Human) - SERTAD3 gene Strong transcriptional coactivator. Indicus|evm.model.CM009508.1.658 P52556 BLVRB_BOVIN 99.515 0.990338 1.00485 BLVRB - Flavin reductase (NADPH) - Bos taurus (Bovine) - BLVRB gene Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. Indicus|evm.model.CM009508.1.659 Q9H254 SPTN4_HUMAN 97.881 0.274464 1.00039 SPTBN4 - Spectrin beta chain, non-erythrocytic 4 - Homo sapiens (Human) - SPTBN4 gene actin filament, axon hillock, axon initial segment, cell body fiber, cytoplasm, cytosol, extracellular exosome, membrane, neuronal cell body, node of Ranvier Indicus|evm.model.CM009508.1.660 A3KMV1 SHKB1_BOVIN 99.858 0.997163 1.00142 SHKBP1 - SH3KBP1-binding protein 1 - Bos taurus (Bovine) - SHKBP1 gene Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. Indicus|evm.model.CM009508.1.661 Q8N2S1 LTBP4_HUMAN 86.839 0.998691 0.940887 LTBP4 - Latent-transforming growth factor beta-binding protein 4 precursor - Homo sapiens (Human) - LTBP4 gene Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Indicus|evm.model.CM009508.1.662 Q9Y6R0 NUMBL_HUMAN 93.924 0.996644 0.978654 NUMBL - Numb-like protein - Homo sapiens (Human) - NUMBL gene Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Indicus|evm.model.CM009508.1.663 Q96D53 COQ8B_HUMAN 90.649 0.994297 0.966912 COQ8B - Atypical kinase COQ8B, mitochondrial - Homo sapiens (Human) - COQ8B gene Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration (PubMed:24270420). Indicus|evm.model.CM009508.1.664 Q96DU7 IP3KC_HUMAN 80.758 0.997041 0.989751 ITPKC - Inositol-trisphosphate 3-kinase C - Homo sapiens (Human) - ITPKC gene Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. Indicus|evm.model.CM009508.1.665 A6QQD2 CS054_BOVIN 100.000 0.994269 1.00287 UPF0692 protein C19orf54 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009508.1.666 Q2KIR1 SNRPA_BOVIN 100.000 0.992933 1.00355 SNRPA - U1 small nuclear ribonucleoprotein A - Bos taurus (Bovine) - SNRPA gene Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity). Indicus|evm.model.CM009508.1.667 Q28038 MIA_BOVIN 100.000 0.984733 1.00769 MIA - Melanoma-derived growth regulatory protein precursor - Bos taurus (Bovine) - MIA gene May function during cartilage development and maintenance. Indicus|evm.model.CM009508.1.668 P61018 RAB4B_HUMAN 71.946 0.990991 1.04225 RAB4B - Ras-related protein Rab-4B - Homo sapiens (Human) - RAB4B gene Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Protein transport. Probably involved in vesicular traffic (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). Indicus|evm.model.CM009508.1.669 Q96KS0 EGLN2_HUMAN 93.120 0.995 0.982801 EGLN2 - Prolyl hydroxylase EGLN2 - Homo sapiens (Human) - EGLN2 gene Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). Indicus|evm.model.CM009508.1.671 Q96FX8 PERP_HUMAN 87.565 0.989189 0.958549 PERP - p53 apoptosis effector related to PMP-22 - Homo sapiens (Human) - PERP gene Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). Indicus|evm.model.CM009508.1.672 O18809 CP2F3_CAPHI 97.632 0.840355 0.918534 CYP2F3 - Cytochrome P450 2F3 - Capra hircus (Goat) - CYP2F3 gene Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. Stereoselectively catalyzes the formation of the 1R,2S-oxide from naphthalene. Lack activity with other common P450 substrates including 7-ethoxycoumarin. Indicus|evm.model.CM009508.1.673 Q0P594 PP2AB_BOVIN 99.676 0.993548 1.00324 PPP2CB - Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform - Bos taurus (Bovine) - PPP2CB gene PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Indicus|evm.model.CM009508.1.674 Q16696 CP2AD_HUMAN 90.826 0.953947 0.923077 CYP2A13 - Cytochrome P450 2A13 - Homo sapiens (Human) - CYP2A13 gene Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. Indicus|evm.model.CM009508.1.675 P24461 CP2G1_RABIT 91.296 0.99596 1.00202 CYP2G1 - Cytochrome P450 2G1 - Oryctolagus cuniculus (Rabbit) - CYP2G1 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction. Indicus|evm.model.CM009508.1.676 P00178 CP2B4_RABIT 69.307 0.17094 1.19145 CYP2B4 - Cytochrome P450 2B4 - Oryctolagus cuniculus (Rabbit) - CYP2B4 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin. Indicus|evm.model.CM009508.1.678 P00178 CP2B4_RABIT 81.953 0.949495 1.00815 CYP2B4 - Cytochrome P450 2B4 - Oryctolagus cuniculus (Rabbit) - CYP2B4 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin. Indicus|evm.model.CM009508.1.679 Q8N6M6 AMPO_HUMAN 77.647 0.603571 0.34188 AOPEP - Aminopeptidase O - Homo sapiens (Human) - AOPEP gene Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Indicus|evm.model.CM009508.1.680 P62856 RS26_RAT 95.455 0.486034 1.55652 Rps26 - 40S ribosomal protein S26 - Rattus norvegicus (Rat) - Rps26 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, mRNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009508.1.681 Q96SQ9 CP2S1_HUMAN 79.954 0.966887 0.89881 CYP2S1 - Cytochrome P450 2S1 - Homo sapiens (Human) - CYP2S1 gene A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195). Indicus|evm.model.CM009508.1.682 P30530 UFO_HUMAN 95.186 0.55407 0.920582 AXL - Tyrosine-protein kinase receptor UFO precursor - Homo sapiens (Human) - AXL gene Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. Indicus|evm.model.CM009508.1.683 Q9BUJ2 HNRL1_HUMAN 97.669 0.997672 1.0035 HNRNPUL1 - Heterogeneous nuclear ribonucleoprotein U-like protein 1 - Homo sapiens (Human) - HNRNPUL1 gene Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. Indicus|evm.model.CM009508.1.684 Q96F63 CCD97_HUMAN 89.504 0.994152 0.997085 CCDC97 - Coiled-coil domain-containing protein 97 - Homo sapiens (Human) - CCDC97 gene Indicus|evm.model.CM009508.1.685 P18341 TGFB1_BOVIN 99.410 0.936288 0.925641 TGFB1 - Transforming growth factor beta-1 proprotein precursor - Bos taurus (Bovine) - TGFB1 gene Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Indicus|evm.model.CM009508.1.686 Q56JY9 B9D2_BOVIN 100.000 0.988636 1.00571 B9D2 - B9 domain-containing protein 2 - Bos taurus (Bovine) - B9D2 gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Indicus|evm.model.CM009508.1.687 Q6ZNR0 TMM91_HUMAN 83.721 0.928571 1.05814 TMEM91 - Transmembrane protein 91 - Homo sapiens (Human) - TMEM91 gene Indicus|evm.model.CM009508.1.688 Q9NQT4 EXOS5_HUMAN 88.843 0.99177 1.03404 EXOSC5 - Exosome complex component RRP46 - Homo sapiens (Human) - EXOSC5 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Indicus|evm.model.CM009508.1.689 P11178 ODBA_BOVIN 99.777 0.995556 0.989011 BCKDHA - 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - BCKDHA gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Indicus|evm.model.CM009508.1.690 A6QNS9 DMAC2_BOVIN 100.000 0.367378 2.1794 DMAC2 - Distal membrane-arm assembly complex protein 2 - Bos taurus (Bovine) - DMAC2 gene Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. Indicus|evm.model.CM009508.1.691 A6NGS2 ERIC4_HUMAN 69.466 0.984848 1.01538 ERICH4 - Glutamate-rich protein 4 - Homo sapiens (Human) - ERICH4 gene Indicus|evm.model.CM009508.1.692 Q3SYY2 TPST2_BOVIN 51.579 0.98125 0.424403 TPST2 - Protein-tyrosine sulfotransferase 2 - Bos taurus (Bovine) - TPST2 gene Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. Indicus|evm.model.CM009508.1.694 Q14002 CEAM7_HUMAN 53.719 0.529412 1.60377 CEACAM7 - Carcinoembryonic antigen-related cell adhesion molecule 7 precursor - Homo sapiens (Human) - CEACAM7 gene apical plasma membrane, extracellular region, plasma membrane Indicus|evm.model.CM009508.1.696 P16386 LIPS_BOVIN 99.206 0.723873 1.37963 LIPE - Hormone-sensitive lipase - Bos taurus (Bovine) - LIPE gene Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (By similarity). Shows a preferential hydrolysis of DAGs over TAGs and MAGs (By similarity). Preferentially hydrolyzes fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs and FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity). Indicus|evm.model.CM009508.1.697 Q0VBW2 CNFN_BOVIN 100.000 0.88 1.12613 CNFN - Cornifelin - Bos taurus (Bovine) - CNFN gene Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Indicus|evm.model.CM009508.1.698 Q9QYP0 MEGF8_RAT 95.493 0.99886 0.629125 Megf8 - Multiple epidermal growth factor-like domains protein 8 precursor - Rattus norvegicus (Rat) - Megf8 gene Acts as a negative regulator of hedgehog signaling. Indicus|evm.model.CM009508.1.699 P60882 MEGF8_MOUSE 94.629 0.984848 0.141986 Megf8 - Multiple epidermal growth factor-like domains protein 8 precursor - Mus musculus (Mouse) - Megf8 gene Acts as a negative regulator of hedgehog signaling (PubMed:29290584). Indicus|evm.model.CM009508.1.700 Q7Z7M0 MEGF8_HUMAN 93.716 0.978873 0.199649 MEGF8 - Multiple epidermal growth factor-like domains protein 8 precursor - Homo sapiens (Human) - MEGF8 gene Acts as a negative regulator of hedgehog signaling. Indicus|evm.model.CM009508.1.701 Q8NBT3 TM145_HUMAN 94.792 0.849291 1.14402 TMEM145 - Transmembrane protein 145 - Homo sapiens (Human) - TMEM145 gene Indicus|evm.model.CM009508.1.702 Q0P5M0 PRR19_BOVIN 100.000 0.94026 1.06061 PRR19 - Proline-rich protein 19 - Bos taurus (Bovine) - PRR19 gene Indicus|evm.model.CM009508.1.703 Q29460 PA1B3_BOVIN 100.000 0.991416 1.00431 PAFAH1B3 - Platelet-activating factor acetylhydrolase IB subunit alpha1 - Bos taurus (Bovine) - PAFAH1B3 gene Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF (PubMed:10542206). The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition (PubMed:10542206). Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) (PubMed:10542206). Plays an important role during the development of brain. Indicus|evm.model.CM009508.1.705 Q96RK0 CIC_HUMAN 92.322 0.624013 1.57463 CIC - Protein capicua homolog - Homo sapiens (Human) - CIC gene Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. Indicus|evm.model.CM009508.1.706 P50548 ERF_HUMAN 96.390 0.996383 1.00912 ERF - ETS domain-containing transcription factor ERF - Homo sapiens (Human) - ERF gene Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). Indicus|evm.model.CM009508.1.707 P49840 GSK3A_HUMAN 96.495 0.995338 0.888199 GSK3A - Glycogen synthase kinase-3 alpha - Homo sapiens (Human) - GSK3A gene Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Indicus|evm.model.CM009508.1.708 A6QR00 ZN526_BOVIN 100.000 0.99705 1.00148 ZNF526 - Zinc finger protein 526 - Bos taurus (Bovine) - ZNF526 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.709 Q8WXF8 DEDD2_HUMAN 93.884 0.993902 1.00613 DEDD2 - DNA-binding death effector domain-containing protein 2 - Homo sapiens (Human) - DEDD2 gene May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Indicus|evm.model.CM009508.1.710 P09086 PO2F2_HUMAN 99.317 0.490756 1.24217 POU2F2 - POU domain, class 2, transcription factor 2 - Homo sapiens (Human) - POU2F2 gene Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874). Indicus|evm.model.CM009508.1.711 Q29RK0 ZN574_BOVIN 100.000 0.997537 0.90625 ZNF574 - Zinc finger protein 574 - Bos taurus (Bovine) - ZNF574 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.712 Q63273 GRIK5_RAT 86.528 0.89641 0.995914 Grik5 - Glutamate receptor ionotropic, kainate 5 precursor - Rattus norvegicus (Rat) - Grik5 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA. Indicus|evm.model.CM009508.1.713 P13637 AT1A3_HUMAN 99.385 0.997951 0.963475 ATP1A3 - Sodium/potassium-transporting ATPase subunit alpha-3 - Homo sapiens (Human) - ATP1A3 gene This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Indicus|evm.model.CM009508.1.714 Q1RMH4 PRAF1_BOVIN 99.459 0.736 1.35135 RABAC1 - Prenylated Rab acceptor protein 1 - Bos taurus (Bovine) - RABAC1 gene General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1. Indicus|evm.model.CM009508.1.715 A0A1W2PQ73 ERFL_HUMAN 94.350 0.948925 1.05085 ERFL - ETS domain-containing transcription factor ERF-like - Homo sapiens (Human) - ERFL gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, cell differentiation, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009508.1.716 Q92888 ARHG1_HUMAN 79.300 0.82862 1.27961 ARHGEF1 - Rho guanine nucleotide exchange factor 1 - Homo sapiens (Human) - ARHGEF1 gene Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:9641915, PubMed:9641916, PubMed:8810315, PubMed:30521495). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). Indicus|evm.model.CM009508.1.717 P40293 CD79A_BOVIN 100.000 0.991071 1.00448 CD79A - B-cell antigen receptor complex-associated protein alpha chain precursor - Bos taurus (Bovine) - CD79A gene Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells (By similarity). Indicus|evm.model.CM009508.1.718 Q5R8M9 RS19_PONAB 100.000 0.986301 1.0069 RPS19 - 40S ribosomal protein S19 - Pongo abelii (Sumatran orangutan) - RPS19 gene Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Indicus|evm.model.CM009508.1.719 Q32LE6 DMRTD_BOVIN 99.730 0.994609 1.0027 DMRTC2 - Doublesex- and mab-3-related transcription factor C2 - Bos taurus (Bovine) - DMRTC2 gene May be involved in sexual development. Indicus|evm.model.CM009508.1.721 Q32LD3 LYPD4_BOVIN 100.000 0.991903 1.00407 LYPD4 - Ly6/PLAUR domain-containing protein 4 precursor - Bos taurus (Bovine) - LYPD4 gene anchored component of plasma membrane, plasma membrane raft Indicus|evm.model.CM009508.1.722 P13688 CEAM1_HUMAN 54.113 0.326676 1.3327 CEACAM1 - Carcinoembryonic antigen-related cell adhesion molecule 1 precursor - Homo sapiens (Human) - CEACAM1 gene Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). Indicus|evm.model.CM009508.1.723 P13688 CEAM1_HUMAN 49.141 0.501736 1.09506 CEACAM1 - Carcinoembryonic antigen-related cell adhesion molecule 1 precursor - Homo sapiens (Human) - CEACAM1 gene Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). Indicus|evm.model.CM009508.1.725 A4IFR0 CXL17_BOVIN 99.153 0.983193 1.00847 CXCL17 - C-X-C motif chemokine 17 precursor - Bos taurus (Bovine) - CXCL17 gene Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions. Indicus|evm.model.CM009508.1.726 Q8N6Q3 CD177_HUMAN 53.318 0.963883 1.01373 CD177 - CD177 antigen precursor - Homo sapiens (Human) - CD177 gene In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369). Indicus|evm.model.CM009508.1.727 Q9BY14 TX101_HUMAN 54.274 0.913386 1.02008 TEX101 - Testis-expressed protein 101 precursor - Homo sapiens (Human) - TEX101 gene Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity). Indicus|evm.model.CM009508.1.728 P04557 SFP3_BOVIN 96.154 0.286517 1.27143 Seminal plasma protein A3 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009508.1.729 O95274 LYPD3_HUMAN 75.652 0.947075 1.03757 LYPD3 - Ly6/PLAUR domain-containing protein 3 precursor - Homo sapiens (Human) - LYPD3 gene Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression. Indicus|evm.model.CM009508.1.730 Q6NSJ2 PHLB3_HUMAN 80.247 0.996795 0.975 PHLDB3 - Pleckstrin homology-like domain family B member 3 - Homo sapiens (Human) - PHLDB3 gene enzyme binding Indicus|evm.model.CM009508.1.732 Q3T094 ETHE1_BOVIN 100.000 0.992157 1.00394 ETHE1 - Persulfide dioxygenase ETHE1, mitochondrial precursor - Bos taurus (Bovine) - ETHE1 gene Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus. Indicus|evm.model.CM009508.1.733 Q9GM03 ZN575_MACFA 93.151 0.688889 1.21154 ZNF575 - Zinc finger protein 575 - Macaca fascicularis (Crab-eating macaque) - ZNF575 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.734 P18887 XRCC1_HUMAN 84.977 0.99696 1.03949 XRCC1 - DNA repair protein XRCC1 - Homo sapiens (Human) - XRCC1 gene Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity. Indicus|evm.model.CM009508.1.735 Q9CQD7 PINLY_MOUSE 48.731 0.965174 0.948113 Pinlyp - phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein precursor - Mus musculus (Mouse) - Pinlyp gene Indicus|evm.model.CM009508.1.736 Q9CQD7 PINLY_MOUSE 50.314 0.48318 1.54245 Pinlyp - phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein precursor - Mus musculus (Mouse) - Pinlyp gene Indicus|evm.model.CM009508.1.737 Q8WZA9 IRGQ_HUMAN 78.535 0.935561 0.672552 IRGQ - Immunity-related GTPase family Q protein - Homo sapiens (Human) - IRGQ gene Indicus|evm.model.CM009508.1.738 Q9H609 ZN576_HUMAN 82.941 0.908602 1.09412 ZNF576 - Zinc finger protein 576 - Homo sapiens (Human) - ZNF576 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.739 Q96B54 ZN428_HUMAN 91.753 0.989744 1.03723 ZNF428 - Zinc finger protein 428 - Homo sapiens (Human) - ZNF428 gene Indicus|evm.model.CM009508.1.740 Q05588 UPAR_BOVIN 100.000 0.450599 2.02424 PLAUR - Urokinase plasminogen activator surface receptor precursor - Bos taurus (Bovine) - PLAUR gene Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. Indicus|evm.model.CM009508.1.742 Q5R893 H2B1_PONAB 91.150 0.949153 0.936508 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009508.1.743 Q32KW9 IIGP5_BOVIN 99.785 0.995708 1.00215 IRGC - Interferon-inducible GTPase 5 - Bos taurus (Bovine) - IRGC gene Indicus|evm.model.CM009508.1.744 Q6AYF9 IIGP5_RAT 45.013 0.92381 0.907127 Irgc - Interferon-inducible GTPase 5 - Rattus norvegicus (Rat) - Irgc gene endoplasmic reticulum membrane, GTPase activity, cellular response to interferon-beta, defense response Indicus|evm.model.CM009508.1.745 Q2YDD2 SMG9_BOVIN 99.808 0.996161 1.00192 SMG9 - Protein SMG9 - Bos taurus (Bovine) - SMG9 gene Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development. Indicus|evm.model.CM009508.1.746 O15554 KCNN4_HUMAN 89.930 0.993007 1.00468 KCNN4 - Intermediate conductance calcium-activated potassium channel protein 4 - Homo sapiens (Human) - KCNN4 gene Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). Indicus|evm.model.CM009508.1.747 Q6UWN5 LYPD5_HUMAN 73.729 0.625668 0.74502 LYPD5 - Ly6/PLAUR domain-containing protein 5 precursor - Homo sapiens (Human) - LYPD5 gene extracellular region, plasma membrane, laminin binding, cell-matrix adhesion Indicus|evm.model.CM009508.1.748 Q8N7M2 ZN283_HUMAN 86.623 0.996737 0.902798 ZNF283 - Zinc finger protein 283 - Homo sapiens (Human) - ZNF283 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.749 Q494X3 ZN404_HUMAN 81.670 0.981891 0.900362 ZNF404 - Zinc finger protein 404 - Homo sapiens (Human) - ZNF404 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.750 Q02386 ZNF45_HUMAN 83.650 0.992733 1.0088 ZNF45 - Zinc finger protein 45 - Homo sapiens (Human) - ZNF45 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.751 Q14588 ZN234_HUMAN 84.024 0.994109 0.97 ZNF234 - Zinc finger protein 234 - Homo sapiens (Human) - ZNF234 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.752 Q9NYT6 ZN226_HUMAN 83.149 0.875152 1.0274 ZNF226 - Zinc finger protein 226 - Homo sapiens (Human) - ZNF226 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.753 A0JNB1 ZN227_BOVIN 98.985 0.942515 1.06099 ZNF227 - Zinc finger protein 227 - Bos taurus (Bovine) - ZNF227 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.754 Q14590 ZN235_HUMAN 45.536 0.776224 0.193767 ZNF235 - Zinc finger protein 235 - Homo sapiens (Human) - ZNF235 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.755 Q14590 ZN235_HUMAN 80.785 0.997275 0.99458 ZNF235 - Zinc finger protein 235 - Homo sapiens (Human) - ZNF235 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.756 Q9UJU3 ZN112_HUMAN 79.912 0.936788 1.05696 ZNF112 - Zinc finger protein 112 - Homo sapiens (Human) - ZNF112 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.757 Q6UY09 CEA20_HUMAN 52.727 0.77381 1.12752 CEACAM20 - Carcinoembryonic antigen-related cell adhesion molecule 20 precursor - Homo sapiens (Human) - CEACAM20 gene Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response. Indicus|evm.model.CM009508.1.758 D3ZQE1 CEA16_RAT 90.291 0.263969 3.68085 Ceacam16 - Carcinoembryonic antigen-related cell adhesion molecule 16 precursor - Rattus norvegicus (Rat) - Ceacam16 gene Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane. Indicus|evm.model.CM009508.1.759 P20749 BCL3_HUMAN 91.281 0.926582 0.870044 BCL3 - B-cell lymphoma 3 protein - Homo sapiens (Human) - BCL3 gene Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). Indicus|evm.model.CM009508.1.760 Q9ULV8 CBLC_HUMAN 84.524 0.851626 1.03797 CBLC - E3 ubiquitin-protein ligase CBL-C - Homo sapiens (Human) - CBLC gene Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. Indicus|evm.model.CM009508.1.761 Q9MZ08 BCAM_BOVIN 99.841 0.99682 1.00159 BCAM - Basal cell adhesion molecule precursor - Bos taurus (Bovine) - BCAM gene Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity). Indicus|evm.model.CM009508.1.762 Q92692 NECT2_HUMAN 78.189 0.996296 1.00372 NECTIN2 - Nectin-2 precursor - Homo sapiens (Human) - NECTIN2 gene Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). Indicus|evm.model.CM009508.1.763 Q1LZB5 TOM40_BOVIN 100.000 0.994475 1.00277 TOMM40 - Mitochondrial import receptor subunit TOM40 homolog - Bos taurus (Bovine) - TOMM40 gene Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria. Indicus|evm.model.CM009508.1.764 P0DN41 APOE_BOSMU 99.684 0.9 1.10759 APOE - Apolipoprotein E precursor - Bos mutus grunniens (Wild yak) - APOE gene APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells. Indicus|evm.model.CM009508.1.765 Q3SYR5 APOC4_BOVIN 64.567 0.977273 0.692913 APOC4 - Apolipoprotein C-IV precursor - Bos taurus (Bovine) - APOC4 gene May participate in lipoprotein metabolism. Indicus|evm.model.CM009508.1.766 P19034 APOC2_BOVIN 100.000 0.980392 1.0099 APOC2 - Apolipoprotein C-II precursor - Bos taurus (Bovine) - APOC2 gene Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. Indicus|evm.model.CM009508.1.767 Q2NL17 CLPT1_BOVIN 100.000 0.768049 0.971642 CLPTM1 - Cleft lip and palate transmembrane protein 1 homolog - Bos taurus (Bovine) - CLPTM1 gene May play a role in T-cell development. Indicus|evm.model.CM009508.1.768 Q01201 RELB_HUMAN 91.038 0.703827 1.038 RELB - Transcription factor RelB - Homo sapiens (Human) - RELB gene NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). Indicus|evm.model.CM009508.1.769 A0JNI5 CLASR_BOVIN 99.407 0.997037 1.00746 CLASRP - CLK4-associating serine/arginine rich protein - Bos taurus (Bovine) - CLASRP gene Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). Indicus|evm.model.CM009508.1.770 Q8WUU4 ZN296_HUMAN 78.197 0.995789 1 ZNF296 - Zinc finger protein 296 - Homo sapiens (Human) - ZNF296 gene May be a transcriptional corepressor with KLF4. Indicus|evm.model.CM009508.1.771 Q17QA0 GEMI7_BOVIN 100.000 0.984127 1.008 GEMIN7 - Gem-associated protein 7 - Bos taurus (Bovine) - GEMIN7 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity). Indicus|evm.model.CM009508.1.772 A7Z026 PPR37_BOVIN 100.000 0.997143 1.00143 PPP1R37 - Protein phosphatase 1 regulatory subunit 37 - Bos taurus (Bovine) - PPP1R37 gene Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Indicus|evm.model.CM009508.1.773 Q17RQ9 NKPD1_HUMAN 85.572 0.723764 1.35902 NKPD1 - NTPase KAP family P-loop domain-containing protein 1 - Homo sapiens (Human) - NKPD1 gene Indicus|evm.model.CM009508.1.774 Q3T086 TPC6A_BOVIN 100.000 0.9875 1.00629 TRAPPC6A - Trafficking protein particle complex subunit 6A - Bos taurus (Bovine) - TRAPPC6A gene May play a role in vesicular transport during the biogenesis of melanosomes. Indicus|evm.model.CM009508.1.775 A5PJP1 BL1S3_BOVIN 100.000 0.99005 1.005 BLOC1S3 - Biogenesis of lysosome-related organelles complex 1 subunit 3 - Bos taurus (Bovine) - BLOC1S3 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (By similarity). Indicus|evm.model.CM009508.1.776 Q5XG41 DH12A_XENLA 51.037 0.756329 0.993711 hsd17b12-a - Very-long-chain 3-oxoacyl-CoA reductase-A - Xenopus laevis (African clawed frog) - hsd17b12-a gene Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. Indicus|evm.model.CM009508.1.777 Q2M3D2 EX3L2_HUMAN 87.864 0.918552 1.08068 EXOC3L2 - Exocyst complex component 3-like protein 2 - Homo sapiens (Human) - EXOC3L2 gene exocyst, SNARE binding, exocyst localization, exocytosis Indicus|evm.model.CM009508.1.778 Q96L34 MARK4_HUMAN 91.837 0.843787 1.12367 MARK4 - MAP/microtubule affinity-regulating kinase 4 - Homo sapiens (Human) - MARK4 gene Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Indicus|evm.model.CM009508.1.779 Q9XSC6 KCRM_BOVIN 100.000 0.994764 1.00262 CKM - Creatine kinase M-type - Bos taurus (Bovine) - CKM gene Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). Indicus|evm.model.CM009508.1.780 Q2TBQ9 KLC3_BOVIN 99.604 0.865979 1.15248 KLC3 - Kinesin light chain 3 - Bos taurus (Bovine) - KLC3 gene Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Indicus|evm.model.CM009508.1.781 A6QLJ0 ERCC2_BOVIN 100.000 0.997372 1.00132 ERCC2 - General transcription and DNA repair factor IIH helicase subunit XPD - Bos taurus (Bovine) - ERCC2 gene ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. Indicus|evm.model.CM009508.1.782 Q8WUF5 IASPP_HUMAN 86.174 0.901515 1.11594 PPP1R13L - RelA-associated inhibitor - Homo sapiens (Human) - PPP1R13L gene Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Indicus|evm.model.CM009508.1.783 O15446 RPA34_HUMAN 66.160 0.971857 1.0451 POLR1G - DNA-directed RNA polymerase I subunit RPA34 - Homo sapiens (Human) - POLR1G gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Indicus|evm.model.CM009508.1.784 Q1LZ75 ERCC1_BOVIN 100.000 0.755155 1.31973 ERCC1 - DNA excision repair protein ERCC-1 - Bos taurus (Bovine) - ERCC1 gene Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). Indicus|evm.model.CM009508.1.785 P53539 FOSB_HUMAN 97.947 0.994152 1.01183 FOSB - Protein fosB - Homo sapiens (Human) - FOSB gene FosB interacts with Jun proteins enhancing their DNA binding activity. Indicus|evm.model.CM009508.1.786 O70622 RTN2_MOUSE 81.607 0.995754 1 Rtn2 - Reticulon-2 - Mus musculus (Mouse) - Rtn2 gene Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity (By similarity). Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface (By similarity). Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell (PubMed:19720795). Indicus|evm.model.CM009508.1.787 Q8N819 PPM1N_HUMAN 79.767 0.995272 0.983721 PPM1N - Probable protein phosphatase 1N - Homo sapiens (Human) - PPM1N gene cytosol, nucleus, negative regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of canonical Wnt signaling pathway Indicus|evm.model.CM009508.1.788 Q2TA49 VASP_BOVIN 99.739 0.994792 1.00261 VASP - Vasodilator-stimulated phosphoprotein - Bos taurus (Bovine) - VASP gene Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity). Indicus|evm.model.CM009508.1.789 Q05B66 OPA3_BOVIN 100.000 0.985612 0.727749 OPA3 - Optic atrophy 3 protein homolog - Bos taurus (Bovine) - OPA3 gene May play some role in mitochondrial processes. Indicus|evm.model.CM009508.1.791 Q9H6K4 OPA3_HUMAN 84.324 0.983957 1.04469 OPA3 - Optic atrophy 3 protein - Homo sapiens (Human) - OPA3 gene May play some role in mitochondrial processes. Indicus|evm.model.CM009508.1.792 Q1JQB3 GPR4_BOVIN 100.000 0.99449 1.00276 GPR4 - G-protein coupled receptor 4 - Bos taurus (Bovine) - GPR4 gene Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2)/H(+). Indicus|evm.model.CM009508.1.793 O95834 EMAL2_HUMAN 95.963 0.755582 1.31125 EML2 - Echinoderm microtubule-associated protein-like 2 - Homo sapiens (Human) - EML2 gene Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules. Indicus|evm.model.CM009508.1.794 P48546 GIPR_HUMAN 87.387 0.948608 1.00215 GIPR - Gastric inhibitory polypeptide receptor precursor - Homo sapiens (Human) - GIPR gene This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Indicus|evm.model.CM009508.1.795 P62317 SMD2_MOUSE 100.000 0.981651 0.923729 Snrpd2 - Small nuclear ribonucleoprotein Sm D2 - Mus musculus (Mouse) - Snrpd2 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. Indicus|evm.model.CM009508.1.796 Q0V8G3 QPCTL_BOVIN 100.000 0.994792 1.00261 QPCTL - Glutaminyl-peptide cyclotransferase-like protein - Bos taurus (Bovine) - QPCTL gene Responsible for the biosynthesis of pyroglutamyl peptides. Indicus|evm.model.CM009508.1.797 Q86VE0 MYPOP_HUMAN 95.484 0.192982 2 MYPOP - Myb-related transcription factor, partner of profilin - Homo sapiens (Human) - MYPOP gene Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity). Indicus|evm.model.CM009508.1.798 C9JSJ3 MEIOS_HUMAN 66.102 0.843902 0.96395 MEIOSIN - Meiosis initiator protein - Homo sapiens (Human) - MEIOSIN gene Gatekeeper of meiotic initiation in both male and female germ cells. In complex with STRA8, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. Temporal expression of MEIOSIN is required for meiotic entry decision. Indicus|evm.model.CM009508.1.799 Q8N196 SIX5_HUMAN 90.013 0.997294 1 SIX5 - Homeobox protein SIX5 - Homo sapiens (Human) - SIX5 gene Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). Indicus|evm.model.CM009508.1.800 Q09013 DMPK_HUMAN 90.909 0.869841 1.00159 DMPK - Myotonin-protein kinase - Homo sapiens (Human) - DMPK gene Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. Indicus|evm.model.CM009508.1.801 Q09019 DMWD_HUMAN 98.246 0.0833333 0.997033 DMWD - Dystrophia myotonica WD repeat-containing protein - Homo sapiens (Human) - DMWD gene Indicus|evm.model.CM009508.1.802 Q9H0K4 RSH6A_HUMAN 75.923 0.997207 0.998605 RSPH6A - Radial spoke head protein 6 homolog A - Homo sapiens (Human) - RSPH6A gene Essential for sperm flagellar assembly and male fertility. Indicus|evm.model.CM009508.1.803 Q92797 SYMPK_HUMAN 96.546 0.998429 0.999215 SYMPK - Symplekin - Homo sapiens (Human) - SYMPK gene Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. Indicus|evm.model.CM009508.1.805 Q3Y598 FOXA3_BOVIN 100.000 0.994318 1.00285 FOXA3 - Hepatocyte nuclear factor 3-gamma - Bos taurus (Bovine) - FOXA3 gene Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes (By similarity). Indicus|evm.model.CM009508.1.806 P60321 NANO2_HUMAN 86.957 0.985612 1.00725 NANOS2 - Nanos homolog 2 - Homo sapiens (Human) - NANOS2 gene Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity). Indicus|evm.model.CM009508.1.807 Q9UNW9 NOVA2_HUMAN 99.415 0.529595 0.652439 NOVA2 - RNA-binding protein Nova-2 - Homo sapiens (Human) - NOVA2 gene May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA. Indicus|evm.model.CM009508.1.808 Q9Y6R9 CCD61_HUMAN 85.798 0.996101 1.00195 CCDC61 - Centrosomal protein CCDC61 - Homo sapiens (Human) - CCDC61 gene Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). Indicus|evm.model.CM009508.1.809 B5T255 PGRP1_BOSIN 100.000 0.989529 1.00526 PGLYRP1 - Peptidoglycan recognition protein 1 precursor - Bos indicus (Zebu) - PGLYRP1 gene Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor. Indicus|evm.model.CM009508.1.810 P13696 PEBP1_BOVIN 94.118 0.989362 1.00535 PEBP1 - Phosphatidylethanolamine-binding protein 1 - Bos taurus (Bovine) - PEBP1 gene Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Indicus|evm.model.CM009508.1.811 Q6UW32 IGFL1_HUMAN 64.103 0.983051 1.07273 IGFL1 - Insulin growth factor-like family member 1 precursor - Homo sapiens (Human) - IGFL1 gene Probable ligand of the IGFLR1 cell membrane receptor. Indicus|evm.model.CM009508.1.812 Q9Y2N7 HIF3A_HUMAN 88.640 0.997015 1.00149 HIF3A - Hypoxia-inducible factor 3-alpha - Homo sapiens (Human) - HIF3A gene Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity). Indicus|evm.model.CM009508.1.813 P53041 PPP5_HUMAN 97.395 0.996 1.002 PPP5C - Serine/threonine-protein phosphatase 5 - Homo sapiens (Human) - PPP5C gene Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PubMed:14871926, PubMed:16260606, PubMed:21144835). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (PubMed:23102700). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (By similarity). Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (PubMed:16790549). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (PubMed:22781750). Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed:15546861). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (By similarity). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (PubMed:30699359). Indicus|evm.model.CM009508.1.814 A7E321 PNM8A_BOVIN 98.726 0.995754 1 PNMA8A - Paraneoplastic antigen-like protein 8A - Bos taurus (Bovine) - PNMA8A gene Indicus|evm.model.CM009508.1.815 O15145 ARPC3_HUMAN 84.932 0.947368 0.426966 ARPC3 - Actin-related protein 2/3 complex subunit 3 - Homo sapiens (Human) - ARPC3 gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Indicus|evm.model.CM009508.1.816 Q9H0W5 CCDC8_HUMAN 71.639 0.996086 0.949814 CCDC8 - Coiled-coil domain-containing protein 8 - Homo sapiens (Human) - CCDC8 gene Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). Indicus|evm.model.CM009508.1.817 Q9ULN7 PNM8B_HUMAN 62.264 0.351351 0.233071 PNMA8B - Paraneoplastic antigen-like protein 8B - Homo sapiens (Human) - PNMA8B gene Indicus|evm.model.CM009508.1.818 P0DP31 CALM3_RAT 100.000 0.986667 1.00671 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Indicus|evm.model.CM009508.1.819 P79393 PI2R_BOVIN 97.409 0.994805 1 PTGIR - Prostacyclin receptor precursor - Bos taurus (Bovine) - PTGIR gene Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Indicus|evm.model.CM009508.1.820 Q9UK08 GBG8_HUMAN 100.000 0.971831 1.01429 GNG8 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 precursor - Homo sapiens (Human) - GNG8 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009508.1.821 Q96B18 DACT3_HUMAN 97.333 0.57732 0.616852 DACT3 - Dapper homolog 3 - Homo sapiens (Human) - DACT3 gene May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Indicus|evm.model.CM009508.1.822 Q9BZL6 KPCD2_HUMAN 96.113 0.996475 0.969248 PRKD2 - Serine/threonine-protein kinase D2 - Homo sapiens (Human) - PRKD2 gene Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). Indicus|evm.model.CM009508.1.823 P58404 STRN4_MOUSE 93.292 0.996885 0.844737 Strn4 - Striatin-4 - Mus musculus (Mouse) - Strn4 gene Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. Indicus|evm.model.CM009508.1.825 Q9H9S5 FKRP_HUMAN 93.725 0.993952 1.00202 FKRP - Fukutin-related protein - Homo sapiens (Human) - FKRP gene Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:25279699, PubMed:26923585, PubMed:29477842). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:25279699, PubMed:26923585, PubMed:29477842). Indicus|evm.model.CM009508.1.826 Q95JC7 AAAT_BOVIN 100.000 0.996296 1.00186 SLC1A5 - Neutral amino acid transporter B(0) - Bos taurus (Bovine) - SLC1A5 gene Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. Indicus|evm.model.CM009508.1.827 P62744 AP2S1_RAT 100.000 0.986014 1.00704 Ap2s1 - AP-2 complex subunit sigma - Rattus norvegicus (Rat) - Ap2s1 gene Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. May also play a role in extracellular calcium homeostasis (By similarity). Indicus|evm.model.CM009508.1.828 P83509 RHG35_CANLF 98.533 0.998668 1.00067 ARHGAP35 - Rho GTPase-activating protein 35 - Canis lupus familiaris (Dog) - ARHGAP35 gene Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (By similarity). Indicus|evm.model.CM009508.1.829 Q99742 NPAS1_HUMAN 87.710 0.931638 1.0661 NPAS1 - Neuronal PAS domain-containing protein 1 - Homo sapiens (Human) - NPAS1 gene May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity). Indicus|evm.model.CM009508.1.830 Q24JY6 TM160_BOVIN 100.000 0.989418 1.00532 TMEM160 - Transmembrane protein 160 - Bos taurus (Bovine) - TMEM160 gene Indicus|evm.model.CM009508.1.831 Q9UPT8 ZC3H4_HUMAN 91.546 0.3702 0.999233 ZC3H4 - Zinc finger CCCH domain-containing protein 4 - Homo sapiens (Human) - ZC3H4 gene cytosol, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA binding Indicus|evm.model.CM009508.1.832 A2VE14 SAE1_BOVIN 100.000 0.95122 0.947977 SAE1 - SUMO-activating enzyme subunit 1 - Bos taurus (Bovine) - SAE1 gene The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity). Indicus|evm.model.CM009508.1.833 Q9BXH1 BBC3_HUMAN 92.079 0.833333 0.621762 BBC3 - Bcl-2-binding component 3, isoforms 1/2 - Homo sapiens (Human) - BBC3 gene Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338). Indicus|evm.model.CM009508.1.834 Q9Y3X0 CCDC9_HUMAN 79.511 0.90625 1.08475 CCDC9 - Coiled-coil domain-containing protein 9 - Homo sapiens (Human) - CCDC9 gene RNA binding Indicus|evm.model.CM009508.1.835 P79175 C5AR1_GORGO 72.046 0.985714 1 C5AR1 - C5a anaphylatoxin chemotactic receptor 1 - Gorilla gorilla gorilla (Western lowland gorilla) - C5AR1 gene Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Indicus|evm.model.CM009508.1.836 Q9P296 C5AR2_HUMAN 76.261 0.994083 1.00297 C5AR2 - C5a anaphylatoxin chemotactic receptor 2 - Homo sapiens (Human) - C5AR2 gene Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Indicus|evm.model.CM009508.1.837 Q14147 DHX34_HUMAN 88.743 0.998256 1.0035 DHX34 - Probable ATP-dependent RNA helicase DHX34 - Homo sapiens (Human) - DHX34 gene Probable ATP-binding RNA helicase. Indicus|evm.model.CM009508.1.838 Q99687 MEIS3_HUMAN 92.857 0.994695 1.00533 MEIS3 - Homeobox protein Meis3 - Homo sapiens (Human) - MEIS3 gene Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1. Indicus|evm.model.CM009508.1.839 Q9UPR5 NAC2_HUMAN 97.831 0.68071 1.46906 SLC8A2 - Sodium/calcium exchanger 2 precursor - Homo sapiens (Human) - SLC8A2 gene Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion. Indicus|evm.model.CM009508.1.840 P54920 SNAA_HUMAN 98.983 0.993243 1.00339 NAPA - Alpha-soluble NSF attachment protein - Homo sapiens (Human) - NAPA gene Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). Indicus|evm.model.CM009508.1.841 Q4R2Z8 ZN541_MACFA 81.158 0.598513 1.67289 ZNF541 - Zinc finger protein 541 - Macaca fascicularis (Crab-eating macaque) - ZNF541 gene Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis. Indicus|evm.model.CM009508.1.844 Q9NZM4 BICRA_HUMAN 92.938 0.593277 0.762821 BICRA - BRD4-interacting chromatin-remodeling complex-associated protein - Homo sapiens (Human) - BICRA gene Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). Indicus|evm.model.CM009508.1.845 Q9NZN4 EHD2_HUMAN 98.711 0.996324 1.00184 EHD2 - EH domain-containing protein 2 - Homo sapiens (Human) - EHD2 gene ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833). Indicus|evm.model.CM009508.1.846 Q9NZM5 NOP53_HUMAN 84.091 0.928846 1.08787 NOP53 - Ribosome biogenesis protein NOP53 - Homo sapiens (Human) - NOP53 gene Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1 (PubMed:27824081). Indicus|evm.model.CM009508.1.847 O19097 SELW_SHEEP 87.356 0.974026 0.885057 SELENOW - Selenoprotein W - Ovis aries (Sheep) - SELENOW gene Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity). Indicus|evm.model.CM009508.1.848 O15499 GSC2_HUMAN 54.386 0.216216 1.26341 GSC2 - Homeobox protein goosecoid-2 - Homo sapiens (Human) - GSC2 gene May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC. Indicus|evm.model.CM009508.1.849 Q9XSK0 CRX_BOVIN 100.000 0.993333 1.00334 CRX - Cone-rod homeobox protein - Bos taurus (Bovine) - CRX gene Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (By similarity). Indicus|evm.model.CM009508.1.850 O15499 GSC2_HUMAN 54.386 0.243478 1.12195 GSC2 - Homeobox protein goosecoid-2 - Homo sapiens (Human) - GSC2 gene May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC. Indicus|evm.model.CM009508.1.851 P52842 ST2A1_MACFA 74.035 0.993007 1.00351 SULT2A1 - Sulfotransferase 2A1 - Macaca fascicularis (Crab-eating macaque) - SULT2A1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:31100221). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity). Indicus|evm.model.CM009508.1.852 P52842 ST2A1_MACFA 73.333 0.99262 0.950877 SULT2A1 - Sulfotransferase 2A1 - Macaca fascicularis (Crab-eating macaque) - SULT2A1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:31100221). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity). Indicus|evm.model.CM009508.1.853 Q0Q236 BSPH2_MOUSE 42.424 0.907407 0.824427 Bsph2 - Binder of sperm protein homolog 2 precursor - Mus musculus (Mouse) - Bsph2 gene Binds sperm in vitro but has no effect on sperm capacitation. Also binds gelatin and heparin, but not chondroitin sulfate B or phospholipid liposomes. Indicus|evm.model.CM009508.1.854 Q7YR83 ESPB1_PIG 83.408 0.991071 1.00448 ELSPBP1 - Epididymal sperm-binding protein 1 precursor - Sus scrofa (Pig) - ELSPBP1 gene Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity. Indicus|evm.model.CM009508.1.855 Q9N1Q8 CABP5_BOVIN 95.954 0.886598 1.12139 CABP5 - Calcium-binding protein 5 - Bos taurus (Bovine) - CABP5 gene Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (By similarity). Involved in the transmission of light signals (By similarity). May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (By similarity). May play a role in the extension and network organization of neurites (By similarity). Indicus|evm.model.CM009508.1.856 P18858 DNLI1_HUMAN 84.130 0.954119 1.04353 LIG1 - DNA ligase 1 - Homo sapiens (Human) - LIG1 gene DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Indicus|evm.model.CM009508.1.857 Q86XI8 ZSWM9_HUMAN 99.517 0.350937 0.936204 ZSWIM9 - Uncharacterized protein ZSWIM9 - Homo sapiens (Human) - ZSWIM9 gene Indicus|evm.model.CM009508.1.861 Q96M63 ODAD1_HUMAN 60.058 0.940426 1.05224 ODAD1 - Outer dynein arm-docking complex subunit 1 - Homo sapiens (Human) - ODAD1 gene Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Indicus|evm.model.CM009508.1.862 Q58DR6 EMP3_BOVIN 100.000 0.987805 1.00613 EMP3 - Epithelial membrane protein 3 - Bos taurus (Bovine) - EMP3 gene Probably involved in cell proliferation and cell-cell interactions. Indicus|evm.model.CM009508.1.863 Q32PH2 TM143_BOVIN 99.782 0.995643 1.00438 TMEM143 - Transmembrane protein 143 - Bos taurus (Bovine) - TMEM143 gene mitochondrion Indicus|evm.model.CM009508.1.864 Q2YDD6 SNG4_BOVIN 99.145 0.991489 1.00427 SYNGR4 - Synaptogyrin-4 - Bos taurus (Bovine) - SYNGR4 gene Indicus|evm.model.CM009508.1.865 P33946 ERD21_BOVIN 100.000 0.99061 1.00472 KDELR1 - ER lumen protein-retaining receptor 1 - Bos taurus (Bovine) - KDELR1 gene Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. Indicus|evm.model.CM009508.1.866 O15399 NMDE4_HUMAN 93.000 0.942217 0.634731 GRIN2D - Glutamate receptor ionotropic, NMDA 2D precursor - Homo sapiens (Human) - GRIN2D gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750). Indicus|evm.model.CM009508.1.867 Q1JQD2 GRWD1_BOVIN 99.327 0.995526 1.00224 GRWD1 - Glutamate-rich WD repeat-containing protein 1 - Bos taurus (Bovine) - GRWD1 gene Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness. Indicus|evm.model.CM009508.1.869 Q9UNX9 KCJ14_HUMAN 94.495 0.995402 0.997706 KCNJ14 - ATP-sensitive inward rectifier potassium channel 14 - Homo sapiens (Human) - KCNJ14 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity). Indicus|evm.model.CM009508.1.870 Q76MY7 CYH2_CHLAE 99.749 0.995 1.00251 CYTH2 - Cytohesin-2 - Chlorocebus aethiops (Green monkey) - CYTH2 gene Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). Indicus|evm.model.CM009508.1.871 Q96Q04 LMTK3_HUMAN 97.297 0.110443 0.911644 LMTK3 - Serine/threonine-protein kinase LMTK3 precursor - Homo sapiens (Human) - LMTK3 gene Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity). Indicus|evm.model.CM009508.1.872 O00204 ST2B1_HUMAN 71.111 0.96587 0.80274 SULT2B1 - Sulfotransferase 2B1 - Homo sapiens (Human) - SULT2B1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:19589875, PubMed:12145317). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:9799594, PubMed:12145317, PubMed:21855633, PubMed:16855051). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). Indicus|evm.model.CM009508.1.873 Q2M2I3 FA83E_HUMAN 76.411 0.99 1.04603 FAM83E - Protein FAM83E - Homo sapiens (Human) - FAM83E gene May play a role in MAPK signaling. Indicus|evm.model.CM009508.1.874 Q5E973 RL18_BOVIN 100.000 0.989418 1.00532 RPL18 - 60S ribosomal protein L18 - Bos taurus (Bovine) - RPL18 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009508.1.875 Q9NRA0 SPHK2_HUMAN 86.341 0.994774 0.877676 SPHK2 - Sphingosine kinase 2 - Homo sapiens (Human) - SPHK2 gene Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:19168031, PubMed:12954646). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Upregulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). Indicus|evm.model.CM009508.1.876 Q32PF6 DBP_BOVIN 100.000 0.993865 1.00308 DBP - D site-binding protein - Bos taurus (Bovine) - DBP gene This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation (By similarity). Indicus|evm.model.CM009508.1.877 Q866X7 CAH11_BOVIN 85.976 0.993399 0.92378 CA11 - Carbonic anhydrase-related protein 11 precursor - Bos taurus (Bovine) - CA11 gene Does not have a catalytic activity. Indicus|evm.model.CM009508.1.878 Q8WTR8 NET5_HUMAN 79.098 0.878846 1.06339 NTN5 - Netrin-5 precursor - Homo sapiens (Human) - NTN5 gene Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. Indicus|evm.model.CM009508.1.879 Q9TTY3 SEC1_BOVIN 100.000 0.99458 1.00272 SEC1 - Galactoside 2-alpha-L-fucosyltransferase SEC1 - Bos taurus (Bovine) - SEC1 gene Catalyzes the transfer of alpha 1,2-linked fucose to ganglioside GM1 and galacto-N-biose. Indicus|evm.model.CM009508.1.880 Q28113 FUT2_BOVIN 99.128 0.994203 1.00291 FUT2 - Galactoside alpha-(1,2)-fucosyltransferase 2 - Bos taurus (Bovine) - FUT2 gene Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:10814703). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (By similarity). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:20506485). Indicus|evm.model.CM009508.1.881 A7E346 MASTR_BOVIN 100.000 0.99536 1.00233 MAMSTR - MEF2-activating motif and SAP domain-containing transcriptional regulator - Bos taurus (Bovine) - MAMSTR gene Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity). Indicus|evm.model.CM009508.1.882 Q5U651 RAIN_HUMAN 98.148 0.258903 1.07892 RASIP1 - Ras-interacting protein 1 - Homo sapiens (Human) - RASIP1 gene Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. Indicus|evm.model.CM009508.1.883 Q8IYV9 IZUM1_HUMAN 65.130 0.994236 0.991429 IZUMO1 - Izumo sperm-egg fusion protein 1 precursor - Homo sapiens (Human) - IZUMO1 gene Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg (PubMed:15759005). The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:15759005). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:15759005). Indicus|evm.model.CM009508.1.884 F6Q1T7 FUT1_BOVIN 99.167 0.860911 1.15833 FUT1 - Galactoside alpha-(1,2)-fucosyltransferase 1 - Bos taurus (Bovine) - FUT1 gene Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:10814703). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent, fucosylates glycolipids gangliosides GA1 and GM1a (PubMed:10814703). Indicus|evm.model.CM009508.1.885 Q9NSA1 FGF21_HUMAN 84.689 0.990476 1.00478 FGF21 - Fibroblast growth factor 21 precursor - Homo sapiens (Human) - FGF21 gene Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Indicus|evm.model.CM009508.1.886 Q5EA40 BCAT2_BOVIN 100.000 0.994924 1.00254 BCAT2 - Branched-chain-amino-acid aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - BCAT2 gene Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). Indicus|evm.model.CM009508.1.887 Q9MYP6 DHB14_BOVIN 99.630 0.99262 1.0037 HSD17B14 - 17-beta-hydroxysteroid dehydrogenase 14 - Bos taurus (Bovine) - HSD17B14 gene Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro). Indicus|evm.model.CM009508.1.888 Q9H4M7 PKHA4_HUMAN 87.179 0.997439 1.00257 PLEKHA4 - Pleckstrin homology domain-containing family A member 4 - Homo sapiens (Human) - PLEKHA4 gene Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. Indicus|evm.model.CM009508.1.889 Q2KI51 PR15A_BOVIN 98.657 0.997019 1.00149 PPP1R15A - Protein phosphatase 1 regulatory subunit 15A - Bos taurus (Bovine) - PPP1R15A gene Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15' (By similarity). Indicus|evm.model.CM009508.1.890 O00294 TULP1_HUMAN 63.396 0.515686 0.940959 TULP1 - Tubby-related protein 1 - Homo sapiens (Human) - TULP1 gene Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. Indicus|evm.model.CM009508.1.891 Q0P569 NUCB1_BOVIN 96.414 0.995633 0.966245 NUCB1 - Nucleobindin-1 precursor - Bos taurus (Bovine) - NUCB1 gene Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (PubMed:7890746). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). Indicus|evm.model.CM009508.1.892 Q148L6 DHDH_BOVIN 99.701 0.994048 1.00299 DHDH - Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase - Bos taurus (Bovine) - DHDH gene D-xylose 1-dehydrogenase (NADP+) activity, D-xylose catabolic process Indicus|evm.model.CM009508.1.893 O02703 BAX_BOVIN 100.000 0.989637 1.00521 BAX - Apoptosis regulator BAX - Bos taurus (Bovine) - BAX gene Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production (By similarity). Interacts (via a C-terminal 33 residues) with NOL3 (via CARD domain); inhibits BAX activation and translocation and consequently cytochrome c release from mitochondria (By similarity). Indicus|evm.model.CM009508.1.894 O46415 FRIL_BOVIN 100.000 0.988636 1.00571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009508.1.895 A7MB78 GYS1_BOVIN 100.000 0.997286 1.00136 GYS1 - Glycogen [starch] synthase, muscle - Bos taurus (Bovine) - GYS1 gene Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Indicus|evm.model.CM009508.1.896 Q9Y230 RUVB2_HUMAN 99.784 0.99569 1.00216 RUVBL2 - RuvB-like 2 - Homo sapiens (Human) - RUVBL2 gene Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). Indicus|evm.model.CM009508.1.897 P04651 LSHB_BOVIN 100.000 0.985915 1.00709 LHB - Lutropin subunit beta precursor - Bos taurus (Bovine) - LHB gene Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. Indicus|evm.model.CM009508.1.899 Q80VU4 NTF4_MOUSE 92.746 0.909953 1.00957 Ntf4 - Neurotrophin-4 precursor - Mus musculus (Mouse) - Ntf4 gene Could serve as a target-derived trophic factor for sensory and sympathetic neurons. Indicus|evm.model.CM009508.1.900 Q17ST2 KCNA7_MOUSE 93.002 0.952484 0.94683 Kcna7 - Potassium voltage-gated channel subfamily A member 7 - Mus musculus (Mouse) - Kcna7 gene Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channels formed by isoform 1 inactivate faster than channels formed by isoform 2. Indicus|evm.model.CM009508.1.901 Q1RMR2 RU17_BOVIN 100.000 0.728477 0.687927 SNRNP70 - U1 small nuclear ribonucleoprotein 70 kDa - Bos taurus (Bovine) - SNRNP70 gene Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. Indicus|evm.model.CM009508.1.902 Q2KIB6 LIN7B_BOVIN 100.000 0.961538 1.03483 LIN7B - Protein lin-7 homolog B - Bos taurus (Bovine) - LIN7B gene Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). Indicus|evm.model.CM009508.1.903 O75145 LIPA3_HUMAN 99.162 0.998326 1.00084 PPFIA3 - Liprin-alpha-3 - Homo sapiens (Human) - PPFIA3 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009508.1.904 P23327 SRCH_HUMAN 58.788 0.724771 1.2475 HRC - Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor - Homo sapiens (Human) - HRC gene May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. Indicus|evm.model.CM009508.1.905 Q7TN37 TRPM4_MOUSE 81.750 0.983444 0.995878 Trpm4 - Transient receptor potential cation channel subfamily M member 4 - Mus musculus (Mouse) - Trpm4 gene Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:17188667, PubMed:29211714). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway (By similarity). Essential for the migration but not the maturation of dendritic cells (PubMed:18758465). Plays a role in keratinocyte differentiation (By similarity). Indicus|evm.model.CM009508.1.907 Q9GZN6 S6A16_HUMAN 45.619 0.976257 0.972826 SLC6A16 - Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 - Homo sapiens (Human) - SLC6A16 gene integral component of plasma membrane, neurotransmitter transmembrane transporter activity, neurotransmitter transport, sodium ion transmembrane transport Indicus|evm.model.CM009508.1.908 Q9GZN6 S6A16_HUMAN 57.902 0.908864 1.08832 SLC6A16 - Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 - Homo sapiens (Human) - SLC6A16 gene integral component of plasma membrane, neurotransmitter transmembrane transporter activity, neurotransmitter transport, sodium ion transmembrane transport Indicus|evm.model.CM009508.1.909 P62828 RAN_RAT 90.517 0.982906 0.541667 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Indicus|evm.model.CM009508.1.910 Q2KHY8 CD37_BOVIN 100.000 0.917763 1.08571 CD37 - Leukocyte antigen CD37 - Bos taurus (Bovine) - CD37 gene integral component of plasma membrane Indicus|evm.model.CM009508.1.911 Q15562 TEAD2_HUMAN 96.026 0.995575 1.01119 TEAD2 - Transcriptional enhancer factor TEF-4 - Homo sapiens (Human) - TEAD2 gene Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. Indicus|evm.model.CM009508.1.912 Q9UK85 DKKL1_HUMAN 77.778 0.918803 0.966942 DKKL1 - Dickkopf-like protein 1 precursor - Homo sapiens (Human) - DKKL1 gene Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility. Indicus|evm.model.CM009508.1.913 Q2T9R2 KASH5_BOVIN 92.226 0.996473 1.08 KASH5 - Protein KASH5 - Bos taurus (Bovine) - KASH5 gene As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation. Indicus|evm.model.CM009508.1.914 Q96A98 TIP39_HUMAN 85.000 0.746154 1.3 PTH2 - Tuberoinfundibular peptide of 39 residues precursor - Homo sapiens (Human) - PTH2 gene Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. Indicus|evm.model.CM009508.1.915 I3L273 GFY_HUMAN 61.376 0.996448 1.08687 GFY - Golgi-associated olfactory signaling regulator precursor - Homo sapiens (Human) - GFY gene Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling (By similarity). Indicus|evm.model.CM009508.1.916 A4FV52 VGLU1_BOVIN 100.000 0.996435 1.00179 SLC17A7 - Vesicular glutamate transporter 1 - Bos taurus (Bovine) - SLC17A7 gene Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate (By similarity). Indicus|evm.model.CM009508.1.917 Q0VCI6 PIHD1_BOVIN 100.000 0.993127 1.00345 PIH1D1 - PIH1 domain-containing protein 1 - Bos taurus (Bovine) - PIH1D1 gene Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity). Indicus|evm.model.CM009508.1.918 A6QR56 A16A1_BOVIN 94.250 0.997365 0.94875 ALDH16A1 - Aldehyde dehydrogenase family 16 member A1 - Bos taurus (Bovine) - ALDH16A1 gene Indicus|evm.model.CM009508.1.919 P49771 FLT3L_HUMAN 78.771 0.607509 1.24681 FLT3LG - Fms-related tyrosine kinase 3 ligand precursor - Homo sapiens (Human) - FLT3LG gene Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Indicus|evm.model.CM009508.1.920 Q3SZ90 RL13A_BOVIN 99.507 0.990196 1.00493 RPL13A - 60S ribosomal protein L13a - Bos taurus (Bovine) - RPL13A gene Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). Indicus|evm.model.CM009508.1.921 P62282 RS11_RAT 100.000 0.987421 1.00633 Rps11 - 40S ribosomal protein S11 - Rattus norvegicus (Rat) - Rps11 gene cytosolic small ribosomal subunit, membrane, structural constituent of ribosome, osteoblast differentiation Indicus|evm.model.CM009508.1.922 Q2KN22 FCGRN_CAMDR 83.708 0.994366 1 FCGRT - IgG receptor FcRn large subunit p51 precursor - Camelus dromedarius (Dromedary) - FCGRT gene Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB. Indicus|evm.model.CM009508.1.923 Q2KJ39 RCN3_BOVIN 99.587 0.99177 0.740854 RCN3 - Reticulocalbin-3 precursor - Bos taurus (Bovine) - RCN3 gene Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (By similarity). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity). Indicus|evm.model.CM009508.1.924 Q3SWY5 NOSIP_BOVIN 100.000 0.993399 1.00331 NOSIP - Nitric oxide synthase-interacting protein - Bos taurus (Bovine) - NOSIP gene E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity). Indicus|evm.model.CM009508.1.925 Q9ULL5 PRR12_HUMAN 97.167 0.669444 1.0609 PRR12 - Proline-rich protein 12 - Homo sapiens (Human) - PRR12 gene Indicus|evm.model.CM009508.1.926 P10301 RRAS_HUMAN 96.789 0.990868 1.00459 RRAS - Ras-related protein R-Ras precursor - Homo sapiens (Human) - RRAS gene Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). Indicus|evm.model.CM009508.1.927 Q9H7N4 SFR19_HUMAN 93.684 0.625954 0.79878 SCAF1 - Splicing factor, arginine/serine-rich 19 - Homo sapiens (Human) - SCAF1 gene May function in pre-mRNA splicing. Indicus|evm.model.CM009508.1.928 Q4JF28 IRF3_BOVIN 99.760 0.995215 1.0024 IRF3 - Interferon regulatory factor 3 - Bos taurus (Bovine) - IRF3 gene Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. Indicus|evm.model.CM009508.1.929 Q9HB09 B2L12_HUMAN 88.716 0.966038 0.793413 BCL2L12 - Bcl-2-like protein 12 - Homo sapiens (Human) - BCL2L12 gene membrane, nucleus, inhibition of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of transcription by RNA polymerase II, regulation of extrinsic apoptotic signaling pathway Indicus|evm.model.CM009508.1.930 Q63009 ANM1_RAT 99.717 0.99435 1.00283 Prmt1 - Protein arginine N-methyltransferase 1 - Rattus norvegicus (Rat) - Prmt1 gene Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:12737817, PubMed:15837430, PubMed:18492485). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation (By similarity). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (By similarity). May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway (By similarity). Methylates RBM15, promoting ubiquitination and degradation of RBM15 (By similarity). Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (By similarity). Indicus|evm.model.CM009508.1.931 A5LHG2 ADM5_PIG 79.048 0.916667 1 ADM5 - ADM5 precursor - Sus scrofa (Pig) - ADM5 gene Seems to have a peripheral vasodepressor effect and a central vasopressor effect. Indicus|evm.model.CM009508.1.932 Q8TCG5 CPT1C_HUMAN 90.769 0.996154 0.971357 CPT1C - Carnitine O-palmitoyltransferase 1, brain isoform - Homo sapiens (Human) - CPT1C gene May play a role in lipid metabolic process. Indicus|evm.model.CM009508.1.933 Q7TP54 RIPR2_RAT 50.000 0.926316 0.0725191 Ripor2 - Rho family-interacting cell polarization regulator 2 - Rattus norvegicus (Rat) - Ripor2 gene Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (By similarity). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing (By similarity). Indicus|evm.model.CM009508.1.934 P60531 TSKS_RAT 90.273 0.99654 0.988034 Tsks - Testis-specific serine kinase substrate - Rattus norvegicus (Rat) - Tsks gene May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development. Indicus|evm.model.CM009508.1.935 O95782 AP2A1_HUMAN 95.603 0.99789 0.970317 AP2A1 - AP-2 complex subunit alpha-1 - Homo sapiens (Human) - AP2A1 gene Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). Indicus|evm.model.CM009508.1.936 Q9BT04 FUZZY_HUMAN 89.976 0.995238 1.00478 FUZ - Protein fuzzy homolog - Homo sapiens (Human) - FUZ gene Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity). Indicus|evm.model.CM009508.1.937 Q71SY5 MED25_HUMAN 94.632 0.910364 0.955823 MED25 - Mediator of RNA polymerase II transcription subunit 25 - Homo sapiens (Human) - MED25 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. Indicus|evm.model.CM009508.1.938 A4IFC9 PTOV1_BOVIN 100.000 0.994444 0.86747 PTOV1 - Prostate tumor-overexpressed gene 1 protein homolog - Bos taurus (Bovine) - PTOV1 gene May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation (By similarity). Indicus|evm.model.CM009508.1.939 Q96T60 PNKP_HUMAN 85.249 0.977486 1.02303 PNKP - Bifunctional polynucleotide phosphatase/kinase - Homo sapiens (Human) - PNKP gene Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. Indicus|evm.model.CM009508.1.941 Q96B36 AKTS1_HUMAN 95.745 0.8 0.683594 AKT1S1 - Proline-rich AKT1 substrate 1 - Homo sapiens (Human) - AKT1S1 gene Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection. Indicus|evm.model.CM009508.1.942 Q9HA65 TBC17_HUMAN 92.025 0.996937 1.00772 TBC1D17 - TBC1 domain family member 17 - Homo sapiens (Human) - TBC1D17 gene Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known. Indicus|evm.model.CM009508.1.943 O09046 OXLA_MOUSE 73.458 0.90971 0.931746 Il4i1 - L-amino-acid oxidase precursor - Mus musculus (Mouse) - Il4i1 gene Secreted L-amino-acid oxidase that acts as a key immunoregulator (PubMed:32818467). Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively (PubMed:15383589). Also has weak L-arginine oxidase activity (By similarity). Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR (PubMed:21469114, PubMed:28405502, PubMed:32818467). IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer (By similarity). AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Also has an immunoregulatory function in some immune cell, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells (PubMed:25778793, PubMed:29288206). Also regulates M2 macrophage polarization by inhibiting T-cell activation (PubMed:26599209). Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2 (By similarity). Indicus|evm.model.CM009508.1.944 P37198 NUP62_HUMAN 78.707 0.996161 0.998084 NUP62 - Nuclear pore glycoprotein p62 - Homo sapiens (Human) - NUP62 gene Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). Indicus|evm.model.CM009508.1.945 O70191 ATF5_MOUSE 77.663 0.993007 1.0106 Atf5 - Cyclic AMP-dependent transcription factor ATF-5 - Mus musculus (Mouse) - Atf5 gene Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (By similarity). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate. Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (PubMed:22095825). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (PubMed:23090999). May be involved in osteogenic differentiation. Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (By similarity). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity) (PubMed:12130540). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver. In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase. May act as a negative regulator of IL1B transduction pathway in liver. Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members. Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation. Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (By similarity). Indicus|evm.model.CM009508.1.946 Q96RL6 SIG11_HUMAN 57.868 0.687612 0.797994 SIGLEC11 - Sialic acid-binding Ig-like lectin 11 precursor - Homo sapiens (Human) - SIGLEC11 gene Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Indicus|evm.model.CM009508.1.947 Q2YDN8 VRK3_BOVIN 99.778 0.995575 1.00222 VRK3 - Inactive serine/threonine-protein kinase VRK3 - Bos taurus (Bovine) - VRK3 gene Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. Indicus|evm.model.CM009508.1.949 Q6UXV1 IZUM2_HUMAN 71.667 0.472296 1.71493 IZUMO2 - Izumo sperm-egg fusion protein 2 precursor - Homo sapiens (Human) - IZUMO2 gene Indicus|evm.model.CM009508.1.950 Q7Z406 MYH14_HUMAN 95.236 0.988999 0.956892 MYH14 - Myosin-14 - Homo sapiens (Human) - MYH14 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Indicus|evm.model.CM009508.1.951 Q14003 KCNC3_HUMAN 95.812 0.47037 1.07001 KCNC3 - Potassium voltage-gated channel subfamily C member 3 - Homo sapiens (Human) - KCNC3 gene Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484). Indicus|evm.model.CM009508.1.952 P28339 DPOD1_BOVIN 94.854 0.560093 1.54973 POLD1 - DNA polymerase delta catalytic subunit - Bos taurus (Bovine) - POLD1 gene As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites. Indicus|evm.model.CM009508.1.953 Q01892 SPIB_HUMAN 86.641 0.992366 1 SPIB - Transcription factor Spi-B - Homo sapiens (Human) - SPIB gene Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. Indicus|evm.model.CM009508.1.954 P28339 DPOD1_BOVIN 100.000 0.954545 0.079566 POLD1 - DNA polymerase delta catalytic subunit - Bos taurus (Bovine) - POLD1 gene As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites. Indicus|evm.model.CM009508.1.955 Q14324 MYPC2_HUMAN 85.395 0.982051 1.02542 MYBPC2 - Myosin-binding protein C, fast-type - Homo sapiens (Human) - MYBPC2 gene Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Indicus|evm.model.CM009508.1.956 Q32L49 F71E1_BOVIN 99.535 0.990741 1.00465 FAM71E1 - Protein FAM71E1 - Bos taurus (Bovine) - FAM71E1 gene Indicus|evm.model.CM009508.1.957 A1A4M2 EMC10_BOVIN 99.558 0.855513 1.00382 EMC10 - ER membrane protein complex subunit 10 precursor - Bos taurus (Bovine) - EMC10 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways. Indicus|evm.model.CM009508.1.959 Q8TAC2 JOS2_HUMAN 96.277 0.989418 1.00532 JOSD2 - Josephin-2 - Homo sapiens (Human) - JOSD2 gene Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme. Indicus|evm.model.CM009508.1.960 A6ND91 ASPD_HUMAN 86.477 0.754717 1.31095 ASPDH - Putative L-aspartate dehydrogenase - Homo sapiens (Human) - ASPDH gene Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. Indicus|evm.model.CM009508.1.961 Q9NT99 LRC4B_HUMAN 100.000 0.113131 0.69425 LRRC4B - Leucine-rich repeat-containing protein 4B precursor - Homo sapiens (Human) - LRRC4B gene Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity). Indicus|evm.model.CM009508.1.962 Q9BQG1 SYT3_HUMAN 97.800 0.996622 1.00339 SYT3 - Synaptotagmin-3 - Homo sapiens (Human) - SYT3 gene Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Indicus|evm.model.CM009508.1.963 C9J6K1 CS081_HUMAN 84.772 0.984925 1.00505 C19orf81 - Putative uncharacterized protein C19orf81 - Homo sapiens (Human) - C19orf81 gene Indicus|evm.model.CM009508.1.964 Q9Y566 SHAN1_HUMAN 95.769 0.436504 1.01666 SHANK1 - SH3 and multiple ankyrin repeat domains protein 1 - Homo sapiens (Human) - SHANK1 gene Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Indicus|evm.model.CM009508.1.965 Q9Y240 CLC11_HUMAN 87.037 0.993846 1.00619 CLEC11A - C-type lectin domain family 11 member A precursor - Homo sapiens (Human) - CLEC11A gene Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed:27976999). Important for repair and maintenance of adult bone (By similarity). Indicus|evm.model.CM009508.1.966 Q8NGA4 G32P1_HUMAN 52.863 0.506849 1.61029 GPR32P1 - Putative G-protein coupled receptor GPR32P1 - Homo sapiens (Human) - GPR32P1 gene Orphan receptor. Indicus|evm.model.CM009508.1.967 Q9BZG2 PPAT_HUMAN 82.080 0.995575 1.06103 ACP4 - Testicular acid phosphatase precursor - Homo sapiens (Human) - ACP4 gene May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage (PubMed:15219672). May play a role in odontogenesis (PubMed:27843125). Indicus|evm.model.CM009508.1.970 P00752 KLK_PIG 73.361 0.528509 1.85366 Glandular kallikrein precursor - Sus scrofa (Pig) Indicus|evm.model.CM009508.1.971 Q9Y5K2 KLK4_HUMAN 78.571 0.918605 1.01575 KLK4 - Kallikrein-4 precursor - Homo sapiens (Human) - KLK4 gene Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). Indicus|evm.model.CM009508.1.972 Q9Y337 KLK5_HUMAN 75.427 0.993197 1.00341 KLK5 - Kallikrein-5 precursor - Homo sapiens (Human) - KLK5 gene May be involved in desquamation. Indicus|evm.model.CM009508.1.973 Q92876 KLK6_HUMAN 79.918 0.983806 1.0123 KLK6 - Kallikrein-6 precursor - Homo sapiens (Human) - KLK6 gene Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Indicus|evm.model.CM009508.1.974 P49862 KLK7_HUMAN 77.974 0.888889 0.996047 KLK7 - Kallikrein-7 precursor - Homo sapiens (Human) - KLK7 gene May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Indicus|evm.model.CM009508.1.975 O60259 KLK8_HUMAN 71.538 0.992308 1 KLK8 - Kallikrein-8 precursor - Homo sapiens (Human) - KLK8 gene Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. Indicus|evm.model.CM009508.1.976 Q9UKQ9 KLK9_HUMAN 88.511 0.928571 1.008 KLK9 - Kallikrein-9 precursor - Homo sapiens (Human) - KLK9 gene secretory granule, serine-type endopeptidase activity Indicus|evm.model.CM009508.1.977 O43240 KLK10_HUMAN 82.500 0.992883 1.01812 KLK10 - Kallikrein-10 precursor - Homo sapiens (Human) - KLK10 gene Has a tumor-suppressor role for NES1 in breast and prostate cancer. Indicus|evm.model.CM009508.1.978 Q9UBX7 KLK11_HUMAN 82.773 0.944223 0.890071 KLK11 - Kallikrein-11 precursor - Homo sapiens (Human) - KLK11 gene Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. Indicus|evm.model.CM009508.1.979 Q9UKR0 KLK12_HUMAN 78.629 0.991968 1.00403 KLK12 - Kallikrein-12 precursor - Homo sapiens (Human) - KLK12 gene extracellular region, extracellular space, secretory granule, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity, cornification, proteolysis Indicus|evm.model.CM009508.1.980 Q9UKR3 KLK13_HUMAN 80.576 0.992832 1.00722 KLK13 - Kallikrein-13 precursor - Homo sapiens (Human) - KLK13 gene cytoplasm, extracellular region, secretory granule, hydrolase activity, serine-type endopeptidase activity, cornification, proteolysis Indicus|evm.model.CM009508.1.981 Q9P0G3 KLK14_HUMAN 76.953 0.732759 1.30337 KLK14 - Kallikrein-14 precursor - Homo sapiens (Human) - KLK14 gene Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. Indicus|evm.model.CM009508.1.982 A8MTB9 CEA18_HUMAN 58.140 0.479936 1.6224 CEACAM18 - Carcinoembryonic antigen-related cell adhesion molecule 18 precursor - Homo sapiens (Human) - CEACAM18 gene Indicus|evm.model.CM009508.1.983 O43699 SIGL6_HUMAN 59.292 0.614325 0.801325 SIGLEC6 - Sialic acid-binding Ig-like lectin 6 precursor - Homo sapiens (Human) - SIGLEC6 gene Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Indicus|evm.model.CM009508.1.984 Q9NYZ4 SIGL8_HUMAN 58.255 0.557726 1.12826 SIGLEC8 - Sialic acid-binding Ig-like lectin 8 precursor - Homo sapiens (Human) - SIGLEC8 gene Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658). Indicus|evm.model.CM009508.1.985 A8MUV8 ZN727_HUMAN 68.493 0.336449 0.428858 ZNF727 - Putative zinc finger protein 727 - Homo sapiens (Human) - ZNF727 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.987 Q96JC4 ZN479_HUMAN 47.573 0.525773 0.370229 ZNF479 - Zinc finger protein 479 - Homo sapiens (Human) - ZNF479 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.988 Q8N7X8 SIGL1_HUMAN 57.988 0.649606 1.28934 SIGLECL1 - SIGLEC family-like protein 1 - Homo sapiens (Human) - SIGLECL1 gene plasma membrane, sialic acid binding, cell adhesion Indicus|evm.model.CM009508.1.989 Q8N7X8 SIGL1_HUMAN 55.285 0.600985 1.03046 SIGLECL1 - SIGLEC family-like protein 1 - Homo sapiens (Human) - SIGLECL1 gene plasma membrane, sialic acid binding, cell adhesion Indicus|evm.model.CM009508.1.990 Q8HW98 IGLO5_MOUSE 97.917 0.994065 1.00298 Iglon5 - IgLON family member 5 precursor - Mus musculus (Mouse) - Iglon5 gene Indicus|evm.model.CM009508.1.991 Q86VR7 VS10L_HUMAN 72.759 0.977011 1.00346 VSIG10L - V-set and immunoglobulin domain-containing protein 10-like precursor - Homo sapiens (Human) - VSIG10L gene nucleoplasm Indicus|evm.model.CM009508.1.992 Q2TBV3 ETFB_BOVIN 100.000 0.992188 1.00392 ETFB - Electron transfer flavoprotein subunit beta - Bos taurus (Bovine) - ETFB gene Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. Indicus|evm.model.CM009508.1.993 Q8NHS1 CLDN2_HUMAN 76.048 0.988024 1 CLDND2 - Claudin domain-containing protein 2 - Homo sapiens (Human) - CLDND2 gene plasma membrane Indicus|evm.model.CM009508.1.994 Q2KJ11 NKG7_BOVIN 99.394 0.987952 1.00606 NKG7 - Protein NKG7 - Bos taurus (Bovine) - NKG7 gene plasma membrane Indicus|evm.model.CM009508.1.995 P20274 LMIP_BOVIN 100.000 0.988506 1.00578 LIM2 - Lens fiber membrane intrinsic protein - Bos taurus (Bovine) - LIM2 gene Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. Indicus|evm.model.CM009508.1.996 Q96LC7 SIG10_HUMAN 62.283 0.972896 1.00574 SIGLEC10 - Sialic acid-binding Ig-like lectin 10 precursor - Homo sapiens (Human) - SIGLEC10 gene Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity). Indicus|evm.model.CM009508.1.997 Q9NYZ4 SIGL8_HUMAN 67.529 0.436129 1.55311 SIGLEC8 - Sialic acid-binding Ig-like lectin 8 precursor - Homo sapiens (Human) - SIGLEC8 gene Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658). Indicus|evm.model.CM009508.1.998 O43699 SIGL6_HUMAN 62.080 0.591497 1.19426 SIGLEC6 - Sialic acid-binding Ig-like lectin 6 precursor - Homo sapiens (Human) - SIGLEC6 gene Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Indicus|evm.model.CM009508.1.999 Q9Y473 ZN175_HUMAN 78.348 0.911573 1.08158 ZNF175 - Zinc finger protein 175 - Homo sapiens (Human) - ZNF175 gene Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity. Indicus|evm.model.CM009508.1.1000 Q5NVN3 B4GT3_PONAB 46.512 0.758929 0.284987 B4GALT3 - Beta-1,4-galactosyltransferase 3 - Pongo abelii (Sumatran orangutan) - B4GALT3 gene Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Indicus|evm.model.CM009508.1.1001 Q0VC66 CTU1_BOVIN 88.095 0.892857 0.403458 CTU1 - Cytoplasmic tRNA 2-thiolation protein 1 - Bos taurus (Bovine) - CTU1 gene Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Indicus|evm.model.CM009508.1.1002 O15389 SIGL5_HUMAN 63.686 0.978142 0.99637 SIGLEC5 - Sialic acid-binding Ig-like lectin 5 precursor - Homo sapiens (Human) - SIGLEC5 gene Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Indicus|evm.model.CM009508.1.1003 Q08ET2 SIG14_HUMAN 64.628 0.963255 0.962121 SIGLEC14 - Sialic acid-binding Ig-like lectin 14 precursor - Homo sapiens (Human) - SIGLEC14 gene Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. Indicus|evm.model.CM009508.1.1004 Q08ET2 SIG14_HUMAN 62.766 0.964187 0.916667 SIGLEC14 - Sialic acid-binding Ig-like lectin 14 precursor - Homo sapiens (Human) - SIGLEC14 gene Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. Indicus|evm.model.CM009508.1.1005 O43699 SIGL6_HUMAN 59.829 0.920635 0.278146 SIGLEC6 - Sialic acid-binding Ig-like lectin 6 precursor - Homo sapiens (Human) - SIGLEC6 gene Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Indicus|evm.model.CM009508.1.1006 Q08ET2 SIG14_HUMAN 61.214 0.966146 0.969697 SIGLEC14 - Sialic acid-binding Ig-like lectin 14 precursor - Homo sapiens (Human) - SIGLEC14 gene Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. Indicus|evm.model.CM009508.1.1007 Q92839 HYAS1_HUMAN 94.531 0.401899 0.546713 HAS1 - Hyaluronan synthase 1 - Homo sapiens (Human) - HAS1 gene Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity). Indicus|evm.model.CM009508.1.1008 Q61647 HYAS1_MOUSE 89.356 0.883085 0.689537 Has1 - Hyaluronan synthase 1 - Mus musculus (Mouse) - Has1 gene Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate. Indicus|evm.model.CM009508.1.1009 P51523 ZNF84_HUMAN 57.323 0.730129 0.733062 ZNF84 - Zinc finger protein 84 - Homo sapiens (Human) - ZNF84 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1010 Q6PF04 ZN613_HUMAN 53.081 0.889952 0.338736 ZNF613 - Zinc finger protein 613 - Homo sapiens (Human) - ZNF613 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1011 Q6PF04 ZN613_HUMAN 75.244 0.903988 1.09724 ZNF613 - Zinc finger protein 613 - Homo sapiens (Human) - ZNF613 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1012 O94892 ZN432_HUMAN 79.908 0.992378 1.00613 ZNF432 - Zinc finger protein 432 - Homo sapiens (Human) - ZNF432 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1013 Q95K49 ZN614_MACFA 74.567 0.984615 1.00515 ZNF614 - Zinc finger protein 614 - Macaca fascicularis (Crab-eating macaque) - ZNF614 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1014 Q0VCB0 ZN350_BOVIN 99.097 0.995495 0.872299 ZNF350 - Zinc finger protein 350 - Bos taurus (Bovine) - ZNF350 gene Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). Indicus|evm.model.CM009508.1.1015 Q7Z5H5 VN1R4_HUMAN 50.000 0.370518 2.50166 VN1R4 - Vomeronasal type-1 receptor 4 - Homo sapiens (Human) - VN1R4 gene Putative pheromone receptor. Indicus|evm.model.CM009508.1.1016 Q32PI5 2AAA_BOVIN 99.830 0.99661 1.0017 PPP2R1A - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform - Bos taurus (Bovine) - PPP2R1A gene The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Indicus|evm.model.CM009508.1.1017 Q8NFZ6 VN1R2_HUMAN 58.712 0.929329 0.716456 VN1R2 - Vomeronasal type-1 receptor 2 - Homo sapiens (Human) - VN1R2 gene Putative pheromone receptor. Indicus|evm.model.CM009508.1.1020 Q7Z5H5 VN1R4_HUMAN 46.980 0.993289 0.495017 VN1R4 - Vomeronasal type-1 receptor 4 - Homo sapiens (Human) - VN1R4 gene Putative pheromone receptor. Indicus|evm.model.CM009508.1.1022 Q96SE7 ZN347_HUMAN 58.352 0.483243 1.1025 ZNF347 - Zinc finger protein 347 - Homo sapiens (Human) - ZNF347 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1023 Q9HCG1 ZN160_HUMAN 65.714 0.212308 0.397311 ZNF160 - Zinc finger protein 160 - Homo sapiens (Human) - ZNF160 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1024 Q9HCG1 ZN160_HUMAN 60.394 0.545187 1.2445 ZNF160 - Zinc finger protein 160 - Homo sapiens (Human) - ZNF160 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1025 B2MVY4 CDK4_SHEEP 93.443 0.98913 0.607261 Cyclin-dependent kinase 4 - Ovis aries (Sheep) Indicus|evm.model.CM009508.1.1026 B2MVY4 CDK4_SHEEP 92.453 0.452174 0.379538 Cyclin-dependent kinase 4 - Ovis aries (Sheep) Indicus|evm.model.CM009508.1.1027 Q8IW36 ZN695_HUMAN 61.224 0.372093 0.250485 ZNF695 - Zinc finger protein 695 - Homo sapiens (Human) - ZNF695 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1028 P10575 GLRX1_BOVIN 85.714 0.978261 0.867925 GLRX - Glutaredoxin-1 - Bos taurus (Bovine) - GLRX gene Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Indicus|evm.model.CM009508.1.1029 P56383 AT5G2_MOUSE 75.862 0.934426 0.417808 Atp5mc2 - ATP synthase F(0) complex subunit C2, mitochondrial precursor - Mus musculus (Mouse) - Atp5mc2 gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. Indicus|evm.model.CM009508.1.1031 Q8N5G0 SIM20_HUMAN 95.522 0.970588 1.01493 SMIM20 - Small integral membrane protein 20 - Homo sapiens (Human) - SMIM20 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (PubMed:26321642). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (PubMed:26321642). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (PubMed:26321642). Indicus|evm.model.CM009508.1.1032 Q9HCG1 ZN160_HUMAN 56.461 0.392699 1.10513 ZNF160 - Zinc finger protein 160 - Homo sapiens (Human) - ZNF160 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1033 P61161 ARP2_MOUSE 95.178 0.994937 1.00254 Actr2 - Actin-related protein 2 - Mus musculus (Mouse) - Actr2 gene ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Indicus|evm.model.CM009508.1.1035 Q9H7R5 ZN665_HUMAN 47.531 0.558304 0.417404 ZNF665 - Zinc finger protein 665 - Homo sapiens (Human) - ZNF665 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1037 Q9H7R5 ZN665_HUMAN 63.265 0.303797 0.233038 ZNF665 - Zinc finger protein 665 - Homo sapiens (Human) - ZNF665 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1038 Q96SE7 ZN347_HUMAN 60.143 0.473326 1.05006 ZNF347 - Zinc finger protein 347 - Homo sapiens (Human) - ZNF347 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1039 A6NN14 ZN729_HUMAN 58.406 0.770437 0.713259 ZNF729 - Zinc finger protein 729 - Homo sapiens (Human) - ZNF729 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1040 Q86XU0 ZN677_HUMAN 65.217 0.362903 0.212329 ZNF677 - Zinc finger protein 677 - Homo sapiens (Human) - ZNF677 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1043 Q96SE7 ZN347_HUMAN 59.338 0.687908 0.72944 ZNF347 - Zinc finger protein 347 - Homo sapiens (Human) - ZNF347 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1045 Q96SE7 ZN347_HUMAN 63.158 0.626459 0.612634 ZNF347 - Zinc finger protein 347 - Homo sapiens (Human) - ZNF347 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1048 Q7Z2F6 ZN720_HUMAN 64.865 0.192105 3.01587 ZNF720 - Putative protein ZNF720 - Homo sapiens (Human) - ZNF720 gene Indicus|evm.model.CM009508.1.1049 P63174 RL38_RAT 78.571 0.971831 1.01429 Rpl38 - 60S ribosomal protein L38 - Rattus norvegicus (Rat) - Rpl38 gene cytosolic large ribosomal subunit, eukaryotic 80S initiation complex, polysomal ribosome, postsynaptic density, synapse, structural constituent of ribosome, 90S preribosome assembly, axial mesoderm development, cytoplasmic translation, middle ear morphogenesis Indicus|evm.model.CM009508.1.1050 Q96IR2 ZN845_HUMAN 76.596 0.567901 0.0835052 ZNF845 - Zinc finger protein 845 - Homo sapiens (Human) - ZNF845 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1052 Q5R5Q6 ZN571_PONAB 77.500 0.342105 0.1875 ZNF571 - Zinc finger protein 571 - Pongo abelii (Sumatran orangutan) - ZNF571 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1053 Q28918 STAR_BOVIN 98.131 0.497653 0.747368 STAR - Steroidogenic acute regulatory protein, mitochondrial precursor - Bos taurus (Bovine) - STAR gene Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). Indicus|evm.model.CM009508.1.1054 P30050 RL12_HUMAN 77.576 0.985401 0.830303 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Indicus|evm.model.CM009508.1.1055 Q8TAQ5 ZN420_HUMAN 71.739 0.0310559 2.1061 ZNF420 - Zinc finger protein 420 - Homo sapiens (Human) - ZNF420 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1056 Q5REA0 ZN331_PONAB 93.227 0.690608 0.781857 ZNF331 - Zinc finger protein 331 - Pongo abelii (Sumatran orangutan) - ZNF331 gene May be involved in transcriptional regulation. May play a role in spermatogenesis (By similarity). Indicus|evm.model.CM009508.1.1057 Q8WY07 CTR3_HUMAN 70.178 0.979266 1.01292 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1058 Q8WY07 CTR3_HUMAN 68.908 0.36875 0.516963 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1059 P59046 NAL12_HUMAN 78.889 0.320048 0.780396 NLRP12 - NACHT, LRR and PYD domains-containing protein 12 - Homo sapiens (Human) - NLRP12 gene Plays an essential role as an potent mitigator of inflammation (PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (PubMed:30902577). Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity). Indicus|evm.model.CM009508.1.1061 Q8WY07 CTR3_HUMAN 54.937 0.571723 1.56543 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1063 Q8WY07 CTR3_HUMAN 55.408 0.985222 0.983845 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1064 Q8WY07 CTR3_HUMAN 55.465 0.979066 1.00323 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1065 P70423 CTR3_MOUSE 55.504 0.377917 1.80259 Slc7a3 - Cationic amino acid transporter 3 - Mus musculus (Mouse) - Slc7a3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1066 Q8WY07 CTR3_HUMAN 61.051 0.63847 1.39418 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1067 Q8WY07 CTR3_HUMAN 64.842 0.341657 2.84653 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1068 Q8WY07 CTR3_HUMAN 56.301 0.980707 1.00485 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1069 Q8WY07 CTR3_HUMAN 59.032 0.980952 1.01777 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1070 O08812 CTR3_RAT 58.084 0.887701 0.3021 Slc7a3 - Cationic amino acid transporter 3 - Rattus norvegicus (Rat) - Slc7a3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1071 O08812 CTR3_RAT 59.740 0.77261 1.2504 Slc7a3 - Cationic amino acid transporter 3 - Rattus norvegicus (Rat) - Slc7a3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1072 Q8WY07 CTR3_HUMAN 64.887 0.980892 1.01454 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1073 P30825 SL7A1_HUMAN 66.667 0.0814332 0.976153 SLC7A1 - High affinity cationic amino acid transporter 1 - Homo sapiens (Human) - SLC7A1 gene High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. Indicus|evm.model.CM009508.1.1074 Q8WY07 CTR3_HUMAN 54.202 0.680115 0.560582 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1075 Q8WY07 CTR3_HUMAN 64.640 0.992038 1.01454 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1076 P13619 AT5F1_BOVIN 95.610 0.755556 1.05469 ATP5PB - ATP synthase F(0) complex subunit B1, mitochondrial precursor - Bos taurus (Bovine) - ATP5PB gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Indicus|evm.model.CM009508.1.1077 P47843 GTR3_SHEEP 88.865 0.333333 2.82996 SLC2A3 - Solute carrier family 2, facilitated glucose transporter member 3 - Ovis aries (Sheep) - SLC2A3 gene Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Indicus|evm.model.CM009508.1.1078 Q8WY07 CTR3_HUMAN 51.753 0.973404 0.911147 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009508.1.1079 Q96S97 MYADM_HUMAN 89.441 0.993808 1.00311 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009508.1.1080 P05128 KPCG_BOVIN 100.000 0.975645 1.02346 PRKCG - Protein kinase C gamma type - Bos taurus (Bovine) - PRKCG gene Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock. Indicus|evm.model.CM009508.1.1081 P62957 CCG7_RAT 100.000 0.992754 1.00364 Cacng7 - Voltage-dependent calcium channel gamma-7 subunit - Rattus norvegicus (Rat) - Cacng7 gene Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:18817736, PubMed:19234459). Shows specificity only for GRIA1 and GRIA2 (By similarity). Indicus|evm.model.CM009508.1.1082 Q8WXS5 CCG8_HUMAN 96.992 0.456897 1.36471 CACNG8 - Voltage-dependent calcium channel gamma-8 subunit - Homo sapiens (Human) - CACNG8 gene Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Indicus|evm.model.CM009508.1.1083 Q6UX27 VSTM1_HUMAN 56.757 0.764286 0.59322 VSTM1 - V-set and transmembrane domain-containing protein 1 precursor - Homo sapiens (Human) - VSTM1 gene Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17). Indicus|evm.model.CM009508.1.1086 Q288C4 NLRP9_BOVIN 99.197 0.997994 1.001 NLRP9 - NACHT, LRR and PYD domains-containing protein 9 - Bos taurus (Bovine) - NLRP9 gene As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments. Indicus|evm.model.CM009508.1.1088 D4ABM4 RFPLA_RAT 58.442 0.367647 0.715789 Rfpl4a - Ret finger protein-like 4A - Rattus norvegicus (Rat) - Rfpl4a gene chromatin, cytoplasm, nucleoplasm, nucleus, ubiquitin-protein transferase activity, positive regulation of transcription, DNA-templated Indicus|evm.model.CM009508.1.1089 Q9Y6I3 EPN1_HUMAN 89.410 0.996377 0.958333 EPN1 - Epsin-1 - Homo sapiens (Human) - EPN1 gene Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10557078, PubMed:10393179). Indicus|evm.model.CM009508.1.1090 P26369 U2AF2_MOUSE 86.947 0.995283 0.892632 U2af2 - Splicing factor U2AF 65 kDa subunit - Mus musculus (Mouse) - U2af2 gene Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals. Indicus|evm.model.CM009508.1.1091 Q1LZ89 CC106_BOVIN 100.000 0.992832 1.0036 CCDC106 - Coiled-coil domain-containing protein 106 - Bos taurus (Bovine) - CCDC106 gene Promotes the degradation of p53/TP53 protein and inhibits its transactivity. Indicus|evm.model.CM009508.1.1092 Q9P0T4 ZN581_HUMAN 85.859 0.98995 1.01015 ZNF581 - Zinc finger protein 581 - Homo sapiens (Human) - ZNF581 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1093 Q9UK33 ZN580_HUMAN 94.231 0.895954 1.00581 ZNF580 - Zinc finger protein 580 - Homo sapiens (Human) - ZNF580 gene Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1095 Q8NCA9 ZN784_HUMAN 82.748 0.980952 0.975232 ZNF784 - Zinc finger protein 784 - Homo sapiens (Human) - ZNF784 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1096 P0CJ78 ZN865_HUMAN 96.296 0.200758 0.249292 ZNF865 - Zinc finger protein 865 - Homo sapiens (Human) - ZNF865 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1097 Q96C55 ZN524_HUMAN 85.542 0.924812 1.00758 ZNF524 - Zinc finger protein 524 - Homo sapiens (Human) - ZNF524 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1098 Q96SL8 FIZ1_HUMAN 94.565 0.340824 0.538306 FIZ1 - Flt3-interacting zinc finger protein 1 - Homo sapiens (Human) - FIZ1 gene May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). Indicus|evm.model.CM009508.1.1099 Q80VM4 ZN579_MOUSE 94.958 0.556604 0.377224 Znf579 - Zinc finger protein 579 - Mus musculus (Mouse) - Znf579 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1100 P0C5K0 SBK3_MOUSE 84.416 0.841096 1.01108 Sbk3 - Uncharacterized serine/threonine-protein kinase SBK3 - Mus musculus (Mouse) - Sbk3 gene protein serine/threonine kinase activity Indicus|evm.model.CM009508.1.1101 P0C263 SBK2_HUMAN 77.364 0.90625 1.10345 SBK2 - Serine/threonine-protein kinase SBK2 - Homo sapiens (Human) - SBK2 gene MAP kinase kinase activity, activation of MAPK activity Indicus|evm.model.CM009508.1.1103 A1L4H1 SRCRL_HUMAN 75.501 0.75978 0.926256 SSC5D - Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D precursor - Homo sapiens (Human) - SSC5D gene Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity). Indicus|evm.model.CM009508.1.1104 Q3MHZ1 NAT14_BOVIN 100.000 0.990338 1.00485 NAT14 - N-acetyltransferase 14 - Bos taurus (Bovine) - NAT14 gene Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro (By similarity). Indicus|evm.model.CM009508.1.1105 Q5EBL2 ZN628_HUMAN 70.391 0.953191 0.665722 ZNF628 - Zinc finger protein 628 - Homo sapiens (Human) - ZNF628 gene Transcriptional activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3'. Plays a role in spermiogenesis. Indicus|evm.model.CM009508.1.1107 Q32KX0 ISOC2_BOVIN 100.000 0.387405 2.56863 ISOC2 - Isochorismatase domain-containing protein 2 - Bos taurus (Bovine) - ISOC2 gene cytoplasm Indicus|evm.model.CM009508.1.1108 A6NL88 SHSA7_HUMAN 88.312 0.171171 0.825279 SHISA7 - Protein shisa-7 precursor - Homo sapiens (Human) - SHISA7 gene Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses. Indicus|evm.model.CM009508.1.1109 Q1RML1 UBE2S_BOVIN 100.000 0.991071 1.00448 UBE2S - Ubiquitin-conjugating enzyme E2 S - Bos taurus (Bovine) - UBE2S gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. Indicus|evm.model.CM009508.1.1110 Q3T0L7 RL28_BOVIN 100.000 0.819277 1.21168 RPL28 - 60S ribosomal protein L28 - Bos taurus (Bovine) - RPL28 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009508.1.1112 E1BJD3 TM190_BOVIN 100.000 0.98895 1.00556 TMEM190 - Transmembrane protein 190 precursor - Bos taurus (Bovine) - TMEM190 gene inner acrosomal membrane, hematopoietic progenitor cell differentiation Indicus|evm.model.CM009508.1.1113 P20809 IL11_HUMAN 77.387 0.988304 0.859296 IL11 - Interleukin-11 precursor - Homo sapiens (Human) - IL11 gene Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168). Indicus|evm.model.CM009508.1.1114 Q8N5Q1 F71E2_HUMAN 50.811 0.997658 0.926247 FAM71E2 - Protein FAM71E2 - Homo sapiens (Human) - FAM71E2 gene Indicus|evm.model.CM009508.1.1115 Q6YFP9 CX6B2_BOVIN 100.000 0.977528 1.01136 COX6B2 - Cytochrome c oxidase subunit 6B2 - Bos taurus (Bovine) - COX6B2 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009508.1.1116 Q86Y97 KMT5C_HUMAN 85.345 0.991266 0.991342 KMT5C - Histone-lysine N-methyltransferase KMT5C - Homo sapiens (Human) - KMT5C gene Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). Indicus|evm.model.CM009508.1.1118 A7MBB3 T150B_BOVIN 99.574 0.991525 1.00426 TMEM150B - Modulator of macroautophagy TMEM150B - Bos taurus (Bovine) - TMEM150B gene Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (By similarity). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (By similarity). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (By similarity). Indicus|evm.model.CM009508.1.1119 Q8TDC3 BRSK1_HUMAN 99.429 0.880353 1.02057 BRSK1 - Serine/threonine-protein kinase BRSK1 - Homo sapiens (Human) - BRSK1 gene Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. Indicus|evm.model.CM009508.1.1120 Q99P31 HPBP1_MOUSE 94.958 0.994413 1.0028 Hspbp1 - Hsp70-binding protein 1 - Mus musculus (Mouse) - Hspbp1 gene Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity). Indicus|evm.model.CM009508.1.1121 Q3T0W0 TM86B_BOVIN 99.107 0.208606 4.77232 TMEM86B - Lysoplasmalogenase - Bos taurus (Bovine) - TMEM86B gene Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties. Indicus|evm.model.CM009508.1.1122 Q9HD43 PTPRH_HUMAN 65.934 0.948563 0.592825 PTPRH - Receptor-type tyrosine-protein phosphatase H precursor - Homo sapiens (Human) - PTPRH gene Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity). Indicus|evm.model.CM009508.1.1123 O00445 SYT5_HUMAN 95.337 0.994832 1.00259 SYT5 - Synaptotagmin-5 - Homo sapiens (Human) - SYT5 gene May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity). Indicus|evm.model.CM009508.1.1124 F1MLB4 DAAF3_BOVIN 99.816 0.918782 1.0864 DNAAF3 - Dynein axonemal assembly factor 3 - Bos taurus (Bovine) - DNAAF3 gene Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia (By similarity). Indicus|evm.model.CM009508.1.1125 P08057 TNNI3_BOVIN 100.000 0.99061 1.00472 TNNI3 - Troponin I, cardiac muscle - Bos taurus (Bovine) - TNNI3 gene Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Indicus|evm.model.CM009508.1.1126 Q8MKH6 TNNT1_BOVIN 100.000 0.992424 1.0038 TNNT1 - Troponin T, slow skeletal muscle - Bos taurus (Bovine) - TNNT1 gene Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Indicus|evm.model.CM009508.1.1127 Q9BZL4 PP12C_HUMAN 88.071 0.854356 0.983376 PPP1R12C - Protein phosphatase 1 regulatory subunit 12C - Homo sapiens (Human) - PPP1R12C gene Regulates myosin phosphatase activity. Indicus|evm.model.CM009508.1.1128 Q8TE68 ES8L1_HUMAN 72.244 0.99734 1.04011 EPS8L1 - Epidermal growth factor receptor kinase substrate 8-like protein 1 - Homo sapiens (Human) - EPS8L1 gene Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Indicus|evm.model.CM009508.1.1129 Q8NBN7 RDH13_HUMAN 85.075 0.994048 1.01511 RDH13 - Retinol dehydrogenase 13 - Homo sapiens (Human) - RDH13 gene Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency (PubMed:18039331). Has no activity toward steroids (PubMed:18039331). Indicus|evm.model.CM009508.1.1130 Q14954 KI2S1_HUMAN 52.941 0.521008 1.17434 KIR2DS1 - Killer cell immunoglobulin-like receptor 2DS1 precursor - Homo sapiens (Human) - KIR2DS1 gene Receptor on natural killer (NK) cells for some HLA-C alleles such as w6. Does not inhibit the activity of NK cells. Indicus|evm.model.CM009508.1.1131 P24071 FCAR_HUMAN 55.598 0.917563 0.972125 FCAR - Immunoglobulin alpha Fc receptor precursor - Homo sapiens (Human) - FCAR gene Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. Indicus|evm.model.CM009508.1.1132 Q863H2 NCTR1_BOVIN 85.776 0.877953 0.824675 NCR1 - Natural cytotoxicity triggering receptor 1 precursor - Bos taurus (Bovine) - NCR1 gene Cytotoxicity activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Indicus|evm.model.CM009508.1.1133 Q8WX94 NALP7_HUMAN 60.610 0.889011 0.928571 NLRP7 - NACHT, LRR and PYD domains-containing protein 7 - Homo sapiens (Human) - NLRP7 gene Inhibits CASP1/caspase-1-dependent IL1B secretion. Indicus|evm.model.CM009508.1.1135 Q8N423 LIRB2_HUMAN 46.491 0.418519 0.451505 LILRB2 - Leukocyte immunoglobulin-like receptor subfamily B member 2 precursor - Homo sapiens (Human) - LILRB2 gene Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885). Indicus|evm.model.CM009508.1.1136 Q9NX02 NALP2_HUMAN 64.024 0.997564 0.77307 NLRP2 - NACHT, LRR and PYD domains-containing protein 2 - Homo sapiens (Human) - NLRP2 gene Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Indicus|evm.model.CM009508.1.1137 Q9HCN6 GPVI_HUMAN 72.314 0.983673 0.722714 GP6 - Platelet glycoprotein VI precursor - Homo sapiens (Human) - GP6 gene Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. Indicus|evm.model.CM009508.1.1138 Q8WX94 NALP7_HUMAN 62.628 0.929254 0.533673 NLRP7 - NACHT, LRR and PYD domains-containing protein 7 - Homo sapiens (Human) - NLRP7 gene Inhibits CASP1/caspase-1-dependent IL1B secretion. Indicus|evm.model.CM009508.1.1139 Q9H7L2 KI3X1_HUMAN 50.820 0.675 1.25 KIR3DX1 - Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 precursor - Homo sapiens (Human) - KIR3DX1 gene Indicus|evm.model.CM009508.1.1140 Q8N149 LIRA2_HUMAN 49.688 0.614654 1.52588 LILRA2 - Leukocyte immunoglobulin-like receptor subfamily A member 2 precursor - Homo sapiens (Human) - LILRA2 gene Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061). Indicus|evm.model.CM009508.1.1141 O75022 LIRB3_HUMAN 56.872 0.906475 0.660856 LILRB3 - Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor - Homo sapiens (Human) - LILRB3 gene May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). Indicus|evm.model.CM009508.1.1142 Q6ISS4 LAIR2_HUMAN 52.632 0.370518 1.65132 LAIR2 - Leukocyte-associated immunoglobulin-like receptor 2 precursor - Homo sapiens (Human) - LAIR2 gene extracellular region, regulation of immune response Indicus|evm.model.CM009508.1.1143 Q2KJ98 TTYH1_BOVIN 99.778 0.995565 1.00222 TTYH1 - Protein tweety homolog 1 - Bos taurus (Bovine) - TTYH1 gene Probable chloride channel. May be involved in cell adhesion (By similarity). Indicus|evm.model.CM009508.1.1144 Q96PV6 LENG8_HUMAN 91.995 0.835129 1.16 LENG8 - Leukocyte receptor cluster member 8 - Homo sapiens (Human) - LENG8 gene nucleus Indicus|evm.model.CM009508.1.1145 Q8BTN6 LENG9_MOUSE 56.371 0.944134 1.10722 Leng9 - Leukocyte receptor cluster member 9 - Mus musculus (Mouse) - Leng9 gene Indicus|evm.model.CM009508.1.1146 Q6NZY7 BORG3_HUMAN 71.429 0.518987 0.533784 CDC42EP5 - Cdc42 effector protein 5 - Homo sapiens (Human) - CDC42EP5 gene Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity). Indicus|evm.model.CM009508.1.1147 Q8MJZ2 LIRA6_PANTR 62.927 0.652313 1.30353 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Pan troglodytes (Chimpanzee) - LILRA6 gene May act as receptor for class I MHC antigens. Indicus|evm.model.CM009508.1.1148 Q6PI73 LIRA6_HUMAN 66.452 0.44206 1.45322 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Homo sapiens (Human) - LILRA6 gene May act as receptor for class I MHC antigens. Indicus|evm.model.CM009508.1.1149 Q6PI73 LIRA6_HUMAN 67.217 0.438342 2.00624 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Homo sapiens (Human) - LILRA6 gene May act as receptor for class I MHC antigens. Indicus|evm.model.CM009508.1.1150 O75022 LIRB3_HUMAN 65.147 0.497561 0.974643 LILRB3 - Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor - Homo sapiens (Human) - LILRB3 gene May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). Indicus|evm.model.CM009508.1.1151 Q8MJZ2 LIRA6_PANTR 52.258 0.482759 0.663202 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Pan troglodytes (Chimpanzee) - LILRA6 gene May act as receptor for class I MHC antigens. Indicus|evm.model.CM009508.1.1152 O75022 LIRB3_HUMAN 59.036 0.792608 0.771791 LILRB3 - Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor - Homo sapiens (Human) - LILRB3 gene May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). Indicus|evm.model.CM009508.1.1153 Q8MJZ2 LIRA6_PANTR 64.792 0.541833 1.56549 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Pan troglodytes (Chimpanzee) - LILRA6 gene May act as receptor for class I MHC antigens. Indicus|evm.model.CM009508.1.1154 Q6PI73 LIRA6_HUMAN 62.893 0.822102 0.77131 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Homo sapiens (Human) - LILRA6 gene May act as receptor for class I MHC antigens. Indicus|evm.model.CM009508.1.1155 P59901 LIRA4_HUMAN 72.381 0.0863787 2.41283 LILRA4 - Leukocyte immunoglobulin-like receptor subfamily A member 4 precursor - Homo sapiens (Human) - LILRA4 gene Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760). Indicus|evm.model.CM009508.1.1156 P29314 RS9_RAT 100.000 0.989744 1.00515 Rps9 - 40S ribosomal protein S9 - Rattus norvegicus (Rat) - Rps9 gene cytoplasm, cytosolic small ribosomal subunit, nucleolus, ribonucleoprotein complex, small ribosomal subunit, synapse, 5.8S rRNA binding, rRNA binding, structural constituent of ribosome, translation regulator activity Indicus|evm.model.CM009508.1.1157 Q9BSV6 SEN34_HUMAN 90.997 0.817942 1.22258 TSEN34 - tRNA-splicing endonuclease subunit Sen34 - Homo sapiens (Human) - TSEN34 gene Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Indicus|evm.model.CM009508.1.1158 Q0VCY6 MBOA7_BOVIN 100.000 0.995772 1.00212 MBOAT7 - Lysophospholipid acyltransferase 7 - Bos taurus (Bovine) - MBOAT7 gene Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell. In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation. Indicus|evm.model.CM009508.1.1159 Q7Z404 TMC4_HUMAN 80.899 0.997167 0.991573 TMC4 - Transmembrane channel-like protein 4 - Homo sapiens (Human) - TMC4 gene Probable ion channel. Indicus|evm.model.CM009508.1.1160 Q3T0Z5 LENG1_BOVIN 99.620 0.992424 1.0038 LENG1 - Leukocyte receptor cluster member 1 homolog - Bos taurus (Bovine) - LENG1 gene Indicus|evm.model.CM009508.1.1161 O75175 CNOT3_HUMAN 94.785 0.479351 0.900398 CNOT3 - CCR4-NOT transcription complex subunit 3 - Homo sapiens (Human) - CNOT3 gene Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. Indicus|evm.model.CM009508.1.1162 Q8WWY3 PRP31_HUMAN 99.399 0.996 1.002 PRPF31 - U4/U6 small nuclear ribonucleoprotein Prp31 - Homo sapiens (Human) - PRPF31 gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). Indicus|evm.model.CM009508.1.1163 Q17QH7 TFPT_BOVIN 100.000 0.992063 1.00398 TFPT - TCF3 fusion partner homolog - Bos taurus (Bovine) - TFPT gene Appears to promote apoptosis in a p53/TP53-independent manner. Indicus|evm.model.CM009508.1.1164 Q02371 NDUA3_BOVIN 100.000 0.976471 1.0119 NDUFA3 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 - Bos taurus (Bovine) - NDUFA3 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009508.1.1165 Q8IYS5 OSCAR_HUMAN 69.835 0.84507 1.00709 OSCAR - Osteoclast-associated immunoglobulin-like receptor precursor - Homo sapiens (Human) - OSCAR gene Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Indicus|evm.model.CM009508.1.1166 B6A8C7 TARM1_HUMAN 54.726 0.27983 2.59779 TARM1 - T-cell-interacting, activating receptor on myeloid cells protein 1 precursor - Homo sapiens (Human) - TARM1 gene May act as receptor (By similarity). Negatively regulates TCR-mediated CD4(+) T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface (PubMed:26311901). Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils (By similarity). Indicus|evm.model.CM009508.1.1170 Q86W28 NALP8_HUMAN 53.620 0.937557 1.03912 NLRP8 - NACHT, LRR and PYD domains-containing protein 8 - Homo sapiens (Human) - NLRP8 gene Involved in inflammation. Indicus|evm.model.CM009508.1.1171 Q647I9 NALP5_BOVIN 99.362 0.99818 1.00091 NLRP5 - NACHT, LRR and PYD domains-containing protein 5 - Bos taurus (Bovine) - NLRP5 gene As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum (ER) storage via regulation of ER cellular localization (By similarity). May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (By similarity). Indicus|evm.model.CM009508.1.1172 Q6DD87 ZN787_HUMAN 97.253 0.85782 0.552356 ZNF787 - Zinc finger protein 787 - Homo sapiens (Human) - ZNF787 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1173 Q96S97 MYADM_HUMAN 61.011 0.851852 1.00621 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009508.1.1174 Q9TT95 GALP_PIG 66.372 0.347003 2.64167 GALP - Galanin-like peptide precursor - Sus scrofa (Pig) - GALP gene Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion (By similarity). Indicus|evm.model.CM009508.1.1176 B0JZ89 FA32A_XENTR 93.103 0.77027 0.660714 fam32a - Protein FAM32A - Xenopus tropicalis (Western clawed frog) - fam32a gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Indicus|evm.model.CM009508.1.1177 Q5R9E5 FA32A_PONAB 78.761 0.955752 1.00893 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Indicus|evm.model.CM009508.1.1178 A6NJL1 ZSA5B_HUMAN 68.000 0.209632 0.713131 ZSCAN5B - Zinc finger and SCAN domain-containing protein 5B - Homo sapiens (Human) - ZSCAN5B gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1180 A6NJL1 ZSA5B_HUMAN 52.381 0.97093 0.347475 ZSCAN5B - Zinc finger and SCAN domain-containing protein 5B - Homo sapiens (Human) - ZSCAN5B gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1181 A6NJL1 ZSA5B_HUMAN 62.832 0.191781 1.1798 ZSCAN5B - Zinc finger and SCAN domain-containing protein 5B - Homo sapiens (Human) - ZSCAN5B gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1183 Q5R9E5 FA32A_PONAB 78.761 0.828358 1.19643 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Indicus|evm.model.CM009508.1.1186 Q5R9E5 FA32A_PONAB 75.000 0.933333 0.669643 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Indicus|evm.model.CM009508.1.1188 Q5HYK9 ZN667_HUMAN 86.393 0.915789 1.09016 ZNF667 - Zinc finger protein 667 - Homo sapiens (Human) - ZNF667 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1189 Q96ND8 ZN583_HUMAN 89.399 0.980702 1.00176 ZNF583 - Zinc finger protein 583 - Homo sapiens (Human) - ZNF583 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1190 Q5R9E5 FA32A_PONAB 83.186 0.956897 1.03571 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Indicus|evm.model.CM009508.1.1191 Q5R9E5 FA32A_PONAB 75.806 0.923077 0.580357 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Indicus|evm.model.CM009508.1.1192 Q96NG8 ZN582_HUMAN 87.427 0.652339 1.52998 ZNF582 - Zinc finger protein 582 - Homo sapiens (Human) - ZNF582 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1193 Q9BX82 ZN471_HUMAN 79.585 0.496431 2.01438 ZNF471 - Zinc finger protein 471 - Homo sapiens (Human) - ZNF471 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1194 P0DL12 SIM17_HUMAN 78.814 0.982906 0.991525 SMIM17 - Small integral membrane protein 17 - Homo sapiens (Human) - SMIM17 gene Indicus|evm.model.CM009508.1.1195 Q6ZN57 ZFP2_HUMAN 72.751 0.530055 1.58785 ZFP2 - Zinc finger protein 2 homolog - Homo sapiens (Human) - ZFP2 gene Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance. Indicus|evm.model.CM009508.1.1196 Q9BX82 ZN471_HUMAN 77.159 0.47861 1.19489 ZNF471 - Zinc finger protein 471 - Homo sapiens (Human) - ZNF471 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1200 Q9HBT7 ZN287_HUMAN 53.271 0.646341 0.215506 ZNF287 - Zinc finger protein 287 - Homo sapiens (Human) - ZNF287 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1203 Q6H236 PEG3_BOVIN 89.258 0.975236 0.930457 PEG3 - Paternally-expressed gene 3 protein - Bos taurus (Bovine) - PEG3 gene Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Indicus|evm.model.CM009508.1.1206 A6NLW8 DUXA_HUMAN 73.134 0.358696 0.901961 DUXA - Double homeobox protein A - Homo sapiens (Human) - DUXA gene Putative transcription factor. Indicus|evm.model.CM009508.1.1207 Q9UQB9 AURKC_HUMAN 87.179 0.971429 0.906149 AURKC - Aurora kinase C - Homo sapiens (Human) - AURKC gene Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. Indicus|evm.model.CM009508.1.1208 Q5CZA5 ZN805_HUMAN 86.284 0.995231 1.00319 ZNF805 - Zinc finger protein 805 - Homo sapiens (Human) - ZNF805 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1209 O43296 ZN264_HUMAN 83.522 0.939117 1.04785 ZNF264 - Zinc finger protein 264 - Homo sapiens (Human) - ZNF264 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1210 Q9HCX3 ZN304_HUMAN 81.571 0.560169 1.79059 ZNF304 - Zinc finger protein 304 - Homo sapiens (Human) - ZNF304 gene Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979). Indicus|evm.model.CM009508.1.1213 Q8NEK5 ZN548_HUMAN 60.590 0.984536 1.09193 ZNF548 - Zinc finger protein 548 - Homo sapiens (Human) - ZNF548 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1214 Q6AW86 Z324B_HUMAN 66.176 0.328431 0.375 ZNF324B - Zinc finger protein 324B - Homo sapiens (Human) - ZNF324B gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1216 Q9HCX3 ZN304_HUMAN 67.308 0.893258 0.540212 ZNF304 - Zinc finger protein 304 - Homo sapiens (Human) - ZNF304 gene Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979). Indicus|evm.model.CM009508.1.1217 Q8NEK5 ZN548_HUMAN 51.243 0.975701 1.00375 ZNF548 - Zinc finger protein 548 - Homo sapiens (Human) - ZNF548 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1218 Q6PK81 ZN773_HUMAN 72.907 0.887526 1.10633 ZNF773 - Zinc finger protein 773 - Homo sapiens (Human) - ZNF773 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1219 Q7Z398 ZN550_HUMAN 73.966 0.62212 1.54265 ZNF550 - Zinc finger protein 550 - Homo sapiens (Human) - ZNF550 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1220 Q9HCX3 ZN304_HUMAN 52.586 0.621864 0.846737 ZNF304 - Zinc finger protein 304 - Homo sapiens (Human) - ZNF304 gene Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979). Indicus|evm.model.CM009508.1.1221 Q9BWM5 ZN416_HUMAN 57.841 0.99661 0.993266 ZNF416 - Zinc finger protein 416 - Homo sapiens (Human) - ZNF416 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1223 D2HQI1 ZSCA4_AILME 60.372 0.81039 0.895349 ZSCAN4 - Zinc finger and SCAN domain-containing protein 4 - Ailuropoda melanoleuca (Giant panda) - ZSCAN4 gene Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). Indicus|evm.model.CM009508.1.1224 Q3KQV3 ZN792_HUMAN 74.242 0.305164 0.337025 ZNF792 - Zinc finger protein 792 - Homo sapiens (Human) - ZNF792 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1225 P52741 ZN134_HUMAN 83.684 0.994737 0.88993 ZNF134 - Zinc finger protein 134 - Homo sapiens (Human) - ZNF134 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1226 Q13398 ZN211_HUMAN 51.220 0.5141 0.817376 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1227 Q8TAW3 ZN671_HUMAN 43.678 0.477778 0.337079 ZNF671 - Zinc finger protein 671 - Homo sapiens (Human) - ZNF671 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1228 A8MQ14 ZN850_HUMAN 55.452 0.879346 0.448624 ZNF850 - Zinc finger protein 850 - Homo sapiens (Human) - ZNF850 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1229 Q9Y2P7 ZN256_HUMAN 50.350 0.762735 1.18979 ZNF256 - Zinc finger protein 256 - Homo sapiens (Human) - ZNF256 gene Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity. Indicus|evm.model.CM009508.1.1231 Q13398 ZN211_HUMAN 71.233 0.923077 0.138298 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1232 Q7Z340 ZN551_HUMAN 60.526 0.487132 0.81194 ZNF551 - Zinc finger protein 551 - Homo sapiens (Human) - ZNF551 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1234 Q13398 ZN211_HUMAN 54.516 0.524618 1.04433 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1235 Q13398 ZN211_HUMAN 77.821 0.988327 0.911348 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1237 Q13398 ZN211_HUMAN 59.779 0.955307 0.952128 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1238 P24049 RL17_RAT 93.407 0.978261 0.5 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009508.1.1239 Q13106 ZN154_HUMAN 66.397 0.993939 1.13272 ZNF154 - Zinc finger protein 154 - Homo sapiens (Human) - ZNF154 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1240 Q7Z340 ZN551_HUMAN 53.943 0.62423 0.726866 ZNF551 - Zinc finger protein 551 - Homo sapiens (Human) - ZNF551 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1241 P02301 H3C_MOUSE 94.074 0.748603 1.31618 H3-5 - Histone H3.3C - Mus musculus (Mouse) - H3-5 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009508.1.1242 A8MQ14 ZN850_HUMAN 56.129 0.750754 0.912844 ZNF850 - Zinc finger protein 850 - Homo sapiens (Human) - ZNF850 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1243 Q68DI1 ZN776_HUMAN 73.585 0.641975 0.156371 ZNF776 - Zinc finger protein 776 - Homo sapiens (Human) - ZNF776 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1244 P05386 RLA1_HUMAN 67.544 0.86 0.877193 RPLP1 - 60S acidic ribosomal protein P1 - Homo sapiens (Human) - RPLP1 gene Plays an important role in the elongation step of protein synthesis. Indicus|evm.model.CM009508.1.1245 Q9Y2P7 ZN256_HUMAN 56.550 0.947853 1.03987 ZNF256 - Zinc finger protein 256 - Homo sapiens (Human) - ZNF256 gene Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity. Indicus|evm.model.CM009508.1.1246 A8MQ14 ZN850_HUMAN 54.785 0.698068 0.759633 ZNF850 - Zinc finger protein 850 - Homo sapiens (Human) - ZNF850 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1247 E7ETH6 Z587B_HUMAN 51.515 0.427083 0.955224 ZNF587B - Zinc finger protein 587B - Homo sapiens (Human) - ZNF587B gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1248 Q15370 ELOB_HUMAN 96.610 0.983193 1.00847 ELOB - Elongin-B - Homo sapiens (Human) - ELOB gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). Indicus|evm.model.CM009508.1.1249 Q8NEA5 CS018_HUMAN 59.259 0.526316 1.14884 C19orf18 - Uncharacterized protein C19orf18 precursor - Homo sapiens (Human) - C19orf18 gene extracellular exosome Indicus|evm.model.CM009508.1.1250 Q8WXB4 ZN606_HUMAN 91.035 0.992462 1.00505 ZNF606 - Zinc finger protein 606 - Homo sapiens (Human) - ZNF606 gene May act as a transcriptional repressor. Indicus|evm.model.CM009508.1.1252 Q86UD4 ZN329_HUMAN 78.545 0.992579 0.996303 ZNF329 - Zinc finger protein 329 - Homo sapiens (Human) - ZNF329 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1253 A6QPT6 ZN274_BOVIN 99.839 0.859722 1.16129 ZNF274 - Neurotrophin receptor-interacting factor homolog - Bos taurus (Bovine) - ZNF274 gene Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity). Indicus|evm.model.CM009508.1.1255 Q08DG8 ZN135_BOVIN 65.244 0.336777 0.736682 ZNF135 - Zinc finger protein 135 - Bos taurus (Bovine) - ZNF135 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1257 Q2KJF1 A1BG_BOVIN 98.737 0.686957 1.37177 A1BG - Alpha-1B-glycoprotein precursor - Bos taurus (Bovine) - A1BG gene Indicus|evm.model.CM009508.1.1258 P46782 RS5_HUMAN 100.000 0.990244 1.0049 RPS5 - 40S ribosomal protein S5 - Homo sapiens (Human) - RPS5 gene cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleoplasm, ribonucleoprotein complex, ribosome, mRNA binding Indicus|evm.model.CM009508.1.1260 Q8IVC4 ZN584_HUMAN 62.312 0.853273 1.05226 ZNF584 - Zinc finger protein 584 - Homo sapiens (Human) - ZNF584 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1261 P52740 ZN132_HUMAN 71.650 0.967123 1.03399 ZNF132 - Zinc finger protein 132 - Homo sapiens (Human) - ZNF132 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1262 O75467 Z324A_HUMAN 72.014 0.906355 1.08137 ZNF324 - Zinc finger protein 324A - Homo sapiens (Human) - ZNF324 gene May be involved in transcriptional regulation. May be involved in regulation of cell proliferation. Indicus|evm.model.CM009508.1.1263 Q9NWS9 ZN446_HUMAN 78.788 0.144766 0.997778 ZNF446 - Zinc finger protein 446 - Homo sapiens (Human) - ZNF446 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009508.1.1264 Q9Y2P5 S27A5_HUMAN 77.027 0.842839 1.14348 SLC27A5 - Bile acyl-CoA synthetase - Homo sapiens (Human) - SLC27A5 gene Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:10749848, PubMed:11980911). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed:10749848, PubMed:11980911). Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed:10479480). In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Exhibits long-chain fatty acids (LCFA) transport activity (PubMed:20530735). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity). Indicus|evm.model.CM009508.1.1265 Q13263 TIF1B_HUMAN 95.851 0.98632 0.875449 TRIM28 - Transcription intermediary factor 1-beta - Homo sapiens (Human) - TRIM28 gene Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity). Indicus|evm.model.CM009508.1.1266 Q9DB34 CHM2A_MOUSE 98.649 0.991031 1.0045 Chmp2a - Charged multivesicular body protein 2a - Mus musculus (Mouse) - Chmp2a gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Indicus|evm.model.CM009508.1.1267 P61082 UBC12_MOUSE 100.000 0.98913 1.00546 Ube2m - NEDD8-conjugating enzyme Ubc12 - Mus musculus (Mouse) - Ube2m gene Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. Indicus|evm.model.CM009508.1.1269 P28698 MZF1_HUMAN 96.970 0.268027 1.00136 MZF1 - Myeloid zinc finger 1 - Homo sapiens (Human) - MZF1 gene Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development. Indicus|evm.model.CM009509.1.1 Q8NH37 OR4C3_HUMAN 64.324 0.963351 0.63245 OR4C3 - Olfactory receptor 4C3 - Homo sapiens (Human) - OR4C3 gene Odorant receptor. Indicus|evm.model.CM009509.1.3 A0JN41 CAH10_BOVIN 99.574 0.826855 0.862805 CA10 - Carbonic anhydrase-related protein 10 - Bos taurus (Bovine) - CA10 gene Does not have a catalytic activity. Indicus|evm.model.CM009509.1.4 A0JN41 CAH10_BOVIN 100.000 0.989247 0.283537 CA10 - Carbonic anhydrase-related protein 10 - Bos taurus (Bovine) - CA10 gene Does not have a catalytic activity. Indicus|evm.model.CM009509.1.5 P23588 IF4B_HUMAN 76.378 0.568182 0.360065 EIF4B - Eukaryotic translation initiation factor 4B - Homo sapiens (Human) - EIF4B gene Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. Indicus|evm.model.CM009509.1.7 Q32L59 TMC5B_BOVIN 100.000 0.0725126 1.68946 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Indicus|evm.model.CM009509.1.8 P19419 ELK1_HUMAN 87.500 0.88806 0.313084 ELK1 - ETS domain-containing protein Elk-1 - Homo sapiens (Human) - ELK1 gene Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity). Indicus|evm.model.CM009509.1.10 A0A075B6I7 LV548_HUMAN 76.190 0.722222 1.37143 IGLV5-48 - Probable non-functional immunoglobulin lambda variable 5-48 precursor - Homo sapiens (Human) - IGLV5-48 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Indicus|evm.model.CM009509.1.13 A6H750 KIF2B_BOVIN 98.829 0.997076 1.00146 KIF2B - Kinesin-like protein KIF2B - Bos taurus (Bovine) - KIF2B gene Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement during mitosis. Has microtubule depolymerization activity. Plays a role in chromosome congression. Indicus|evm.model.CM009509.1.15 P39872 RL3_BOVIN 71.111 0.927083 0.238213 RPL3 - 60S ribosomal protein L3 - Bos taurus (Bovine) - RPL3 gene The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Indicus|evm.model.CM009509.1.17 Q0ZQK3 PPIA_SAGOE 80.531 0.760274 0.890244 PPIA - Peptidyl-prolyl cis-trans isomerase A - Saguinus oedipus (Cotton-top tamarin) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009509.1.18 O75674 TM1L1_HUMAN 84.778 0.987342 0.995798 TOM1L1 - TOM1-like protein 1 - Homo sapiens (Human) - TOM1L1 gene Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). Indicus|evm.model.CM009509.1.19 A3KMZ6 COX11_BOVIN 99.645 0.992933 1.00355 COX11 - Cytochrome c oxidase assembly protein COX11, mitochondrial precursor - Bos taurus (Bovine) - COX11 gene Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. Indicus|evm.model.CM009509.1.22 Q90830 CRTAP_CHICK 71.839 0.426065 1.47232 CRTAP - Cartilage-associated protein precursor - Gallus gallus (Chicken) - CRTAP gene Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. Indicus|evm.model.CM009509.1.23 Q16534 HLF_HUMAN 97.966 0.993243 1.00339 HLF - Hepatic leukemia factor - Homo sapiens (Human) - HLF gene chromatin, nucleoplasm, nucleus, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding Indicus|evm.model.CM009509.1.24 Q15546 PAQRB_HUMAN 98.246 0.991266 0.962185 MMD - Monocyte to macrophage differentiation factor - Homo sapiens (Human) - MMD gene Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion. Indicus|evm.model.CM009509.1.25 A0A1B0GRQ0 SIM36_MOUSE 77.419 0.978723 1.01075 SMIM36 - Small integral membrane protein 36 - Mus musculus (Mouse) - SMIM36 gene Indicus|evm.model.CM009509.1.26 Q2KIC8 TM100_BOVIN 99.254 0.985185 1.00746 TMEM100 - Transmembrane protein 100 - Bos taurus (Bovine) - TMEM100 gene Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. Indicus|evm.model.CM009509.1.27 P02720 PPCT_BOVIN 87.234 0.666667 0.323944 PCTP - Phosphatidylcholine transfer protein - Bos taurus (Bovine) - PCTP gene Catalyzes the transfer of phosphatidylcholine between membranes. Binds phosphatidylcholine in a tight 1:1 stoichiometric complex. Indicus|evm.model.CM009509.1.28 P02720 PPCT_BOVIN 61.792 0.981308 1.00469 PCTP - Phosphatidylcholine transfer protein - Bos taurus (Bovine) - PCTP gene Catalyzes the transfer of phosphatidylcholine between membranes. Binds phosphatidylcholine in a tight 1:1 stoichiometric complex. Indicus|evm.model.CM009509.1.29 P02720 PPCT_BOVIN 99.061 0.990654 1.00469 PCTP - Phosphatidylcholine transfer protein - Bos taurus (Bovine) - PCTP gene Catalyzes the transfer of phosphatidylcholine between membranes. Binds phosphatidylcholine in a tight 1:1 stoichiometric complex. Indicus|evm.model.CM009509.1.30 O43422 P52K_HUMAN 92.632 0.65942 0.362681 THAP12 - 52 kDa repressor of the inhibitor of the protein kinase - Homo sapiens (Human) - THAP12 gene Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. Indicus|evm.model.CM009509.1.31 O43422 P52K_HUMAN 95.318 0.993333 0.394218 THAP12 - 52 kDa repressor of the inhibitor of the protein kinase - Homo sapiens (Human) - THAP12 gene Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. Indicus|evm.model.CM009509.1.32 P02720 PPCT_BOVIN 64.943 0.928571 0.85446 PCTP - Phosphatidylcholine transfer protein - Bos taurus (Bovine) - PCTP gene Catalyzes the transfer of phosphatidylcholine between membranes. Binds phosphatidylcholine in a tight 1:1 stoichiometric complex. Indicus|evm.model.CM009509.1.33 Q9UKL6 PPCT_HUMAN 54.930 0.986014 0.668224 PCTP - Phosphatidylcholine transfer protein - Homo sapiens (Human) - PCTP gene Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule. Indicus|evm.model.CM009509.1.34 D3ZDK2 UB2D1_RAT 84.000 0.890909 0.37415 Ube2d1 - Ubiquitin-conjugating enzyme E2 D1 - Rattus norvegicus (Rat) - Ube2d1 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 (By similarity). Mediates ubiquitination of PEX5. Indicus|evm.model.CM009509.1.35 Q8N957 ANKF1_HUMAN 92.121 0.616464 1.40105 ANKFN1 - Ankyrin repeat and fibronectin type-III domain-containing protein 1 - Homo sapiens (Human) - ANKFN1 gene Indicus|evm.model.CM009509.1.36 Q13253 NOGG_HUMAN 97.845 0.991416 1.00431 NOG - Noggin precursor - Homo sapiens (Human) - NOG gene Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732). Indicus|evm.model.CM009509.1.39 Q0P5P2 CQ067_HUMAN 90.541 0.802198 1.01111 C17orf67 - Uncharacterized protein C17orf67 precursor - Homo sapiens (Human) - C17orf67 gene Indicus|evm.model.CM009509.1.40 P52429 DGKE_HUMAN 93.474 0.99646 0.996473 DGKE - Diacylglycerol kinase epsilon - Homo sapiens (Human) - DGKE gene Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:19744926, PubMed:22108654, PubMed:21477596, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:8626589, PubMed:15544348). Also plays an important role in the biosynthesis of complex lipids (PubMed:8626589). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:19744926, PubMed:22108654, PubMed:23274426). Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (PubMed:22108654). Indicus|evm.model.CM009509.1.41 Q14258 TRI25_HUMAN 74.646 0.996835 1.00317 TRIM25 - E3 ubiquitin/ISG15 ligase TRIM25 - Homo sapiens (Human) - TRIM25 gene Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1 (PubMed:17392790, PubMed:30193849). Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Indicus|evm.model.CM009509.1.42 P38432 COIL_HUMAN 72.008 0.966403 0.878472 COIL - Coilin - Homo sapiens (Human) - COIL gene Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. Indicus|evm.model.CM009509.1.43 Q9HB40 RISC_HUMAN 79.646 0.995546 0.993363 SCPEP1 - Retinoid-inducible serine carboxypeptidase precursor - Homo sapiens (Human) - SCPEP1 gene May be involved in vascular wall and kidney homeostasis. Indicus|evm.model.CM009509.1.45 Q93079 H2B1H_HUMAN 91.270 0.984252 1.00794 H2BC9 - Histone H2B type 1-H - Homo sapiens (Human) - H2BC9 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009509.1.46 Q92667 AKAP1_HUMAN 68.467 0.99763 0.934662 AKAP1 - A-kinase anchor protein 1, mitochondrial precursor - Homo sapiens (Human) - AKAP1 gene Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). Indicus|evm.model.CM009509.1.47 Q96DH6 MSI2H_HUMAN 94.796 0.943662 0.865854 MSI2 - RNA-binding protein Musashi homolog 2 - Homo sapiens (Human) - MSI2 gene RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). Indicus|evm.model.CM009509.1.48 Q43083 H4_PYRSA 80.702 0.597826 0.893204 Histone H4 - Pyrenomonas salina Indicus|evm.model.CM009509.1.49 A6NF36 CC182_HUMAN 84.211 0.980519 1.00654 CCDC182 - Coiled-coil domain-containing protein 182 - Homo sapiens (Human) - CCDC182 gene female gonad development Indicus|evm.model.CM009509.1.50 Q2KID7 OSTC_BOVIN 88.158 0.974026 0.516779 OSTC - Oligosaccharyltransferase complex subunit OSTC - Bos taurus (Bovine) - OSTC gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. Indicus|evm.model.CM009509.1.51 Q2NL27 RT23_BOVIN 99.474 0.989529 1.00526 MRPS23 - 28S ribosomal protein S23, mitochondrial - Bos taurus (Bovine) - MRPS23 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009509.1.52 Q9NWM3 CUED1_HUMAN 89.286 0.99403 0.867876 CUEDC1 - CUE domain-containing protein 1 - Homo sapiens (Human) - CUEDC1 gene Indicus|evm.model.CM009509.1.53 Q14119 VEZF1_HUMAN 98.627 0.992141 0.976967 VEZF1 - Vascular endothelial zinc finger 1 - Homo sapiens (Human) - VEZF1 gene Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3. Indicus|evm.model.CM009509.1.54 Q3YLA6 SRSF1_PIG 100.000 0.991968 1.00403 SRSF1 - Serine/arginine-rich splicing factor 1 - Sus scrofa (Pig) - SRSF1 gene Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway (By similarity). Indicus|evm.model.CM009509.1.55 Q78P75 DYL2_RAT 100.000 0.290429 3.40449 Dynll2 - Dynein light chain 2, cytoplasmic - Rattus norvegicus (Rat) - Dynll2 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). Indicus|evm.model.CM009509.1.56 Q15615 OR4D1_HUMAN 80.357 0.973684 0.367742 OR4D1 - Olfactory receptor 4D1 - Homo sapiens (Human) - OR4D1 gene Odorant receptor. Indicus|evm.model.CM009509.1.57 P49290 PERE_MOUSE 77.778 0.315315 0.155028 Epx - Eosinophil peroxidase precursor - Mus musculus (Mouse) - Epx gene Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Indicus|evm.model.CM009509.1.58 P11678 PERE_HUMAN 54.839 0.86747 0.58042 EPX - Eosinophil peroxidase precursor - Homo sapiens (Human) - EPX gene Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. Indicus|evm.model.CM009509.1.59 Q9NXB0 MKS1_HUMAN 91.592 0.996422 1 MKS1 - Meckel syndrome type 1 protein - Homo sapiens (Human) - MKS1 gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Indicus|evm.model.CM009509.1.60 P80025 PERL_BOVIN 100.000 0.997195 1.0014 LPO - Lactoperoxidase precursor - Bos taurus (Bovine) - LPO gene Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae. Indicus|evm.model.CM009509.1.61 P05164 PERM_HUMAN 86.429 0.970833 0.966443 MPO - Myeloperoxidase precursor - Homo sapiens (Human) - MPO gene Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Indicus|evm.model.CM009509.1.62 O95153 RIMB1_HUMAN 83.675 0.609742 0.939688 TSPOAP1 - Peripheral-type benzodiazepine receptor-associated protein 1 - Homo sapiens (Human) - TSPOAP1 gene cytoplasm, cytosol, mitochondrion, benzodiazepine receptor binding, C21-steroid hormone biosynthetic process, neurotransmitter transport Indicus|evm.model.CM009509.1.63 Q4R941 SPT4H_MACFA 100.000 0.983051 1.00855 SUPT4H1 - Transcription elongation factor SPT4 - Macaca fascicularis (Crab-eating macaque) - SUPT4H1 gene Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity). Indicus|evm.model.CM009509.1.64 Q68DV7 RNF43_HUMAN 83.653 0.997449 1.00128 RNF43 - E3 ubiquitin-protein ligase RNF43 precursor - Homo sapiens (Human) - RNF43 gene E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity). Indicus|evm.model.CM009509.1.65 Q5ND04 HSF5_MOUSE 89.144 0.288146 2.63622 Hsf5 - Heat shock factor protein 5 - Mus musculus (Mouse) - Hsf5 gene May act as a transcriptional factor. Indicus|evm.model.CM009509.1.66 P28661 SEPT4_MOUSE 93.231 0.455544 2.09414 Septin4 - Septin-4 - Mus musculus (Mouse) - Septin4 gene Filament-forming cytoskeletal GTPase (By similarity). Plays an important role in male fertility and sperm motility (PubMed:15737930, PubMed:15737931). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (PubMed:15737930, PubMed:15737931). Indicus|evm.model.CM009509.1.67 F1MJR8 TEX14_BOVIN 94.148 0.998663 1.00201 TEX14 - Inactive serine/threonine-protein kinase TEX14 - Bos taurus (Bovine) - TEX14 gene Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity). Indicus|evm.model.CM009509.1.68 Q5RD86 DDA1_PONAB 75.258 0.914286 1.02941 DDA1 - DET1- and DDB1-associated protein 1 - Pongo abelii (Sumatran orangutan) - DDA1 gene Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex. Indicus|evm.model.CM009509.1.69 O43502 RA51C_HUMAN 89.946 0.830317 1.17553 RAD51C - DNA repair protein RAD51 homolog 3 - Homo sapiens (Human) - RAD51C gene Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. Indicus|evm.model.CM009509.1.71 Q8WY54 PPM1E_HUMAN 93.682 0.810284 0.74702 PPM1E - Protein phosphatase 1E - Homo sapiens (Human) - PPM1E gene Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity). Indicus|evm.model.CM009509.1.72 Q2TBY0 SKA2_BOVIN 98.990 0.0921919 8.78512 SKA2 - Spindle and kinetochore-associated protein 2 - Bos taurus (Bovine) - SKA2 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Indicus|evm.model.CM009509.1.73 Q96HE9 PRR11_HUMAN 78.363 0.837838 1.13056 PRR11 - Proline-rich protein 11 - Homo sapiens (Human) - PRR11 gene Plays a critical role in cell cycle progression. Indicus|evm.model.CM009509.1.74 A1A4J7 SMG8_BOVIN 99.900 0.998 1.001 SMG8 - Protein SMG8 - Bos taurus (Bovine) - SMG8 gene Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity). Indicus|evm.model.CM009509.1.75 Q8N9F7 GDPD1_HUMAN 95.527 0.990476 1.00318 GDPD1 - Lysophospholipase D GDPD1 - Homo sapiens (Human) - GDPD1 gene Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550, PubMed:25596343). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC) (PubMed:27637550, PubMed:25596343). May be involved in bioactive N-acylethanolamine biosynthesis from both N-acyl-lysoplasmenylethanolamin (N-acyl-lysoPlsEt) and N-acyl-lysophosphatidylethanolamin (N-acyl-lysoPE) (PubMed:27637550, PubMed:25596343). In addition, hydrolyzes glycerophospho-N-acylethanolamine to N-acylethanolamine (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine (By similarity). Indicus|evm.model.CM009509.1.77 Q5RDN9 YPEL2_PONAB 100.000 0.983333 1.0084 YPEL2 - Protein yippee-like 2 - Pongo abelii (Sumatran orangutan) - YPEL2 gene Indicus|evm.model.CM009509.1.78 Q0VCP1 KAD4_BOVIN 97.309 0.991071 1.00448 AK4 - Adenylate kinase 4, mitochondrial - Bos taurus (Bovine) - AK4 gene Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular response to oxidative stress (By similarity). Indicus|evm.model.CM009509.1.79 Q5R864 DHX40_PONAB 98.588 0.997436 1.00128 DHX40 - Probable ATP-dependent RNA helicase DHX40 - Pongo abelii (Sumatran orangutan) - DHX40 gene Probable ATP-dependent RNA helicase. Indicus|evm.model.CM009509.1.80 P49951 CLH1_BOVIN 97.552 0.998777 0.976119 CLTC - Clathrin heavy chain 1 - Bos taurus (Bovine) - CLTC gene Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Indicus|evm.model.CM009509.1.81 Q3ZBL5 PTH2_BOVIN 100.000 0.847619 1.17318 PTRH2 - Peptidyl-tRNA hydrolase 2, mitochondrial precursor - Bos taurus (Bovine) - PTRH2 gene The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Indicus|evm.model.CM009509.1.82 Q0VCK9 VMP1_BOVIN 100.000 0.995086 1.00246 VMP1 - Vacuole membrane protein 1 - Bos taurus (Bovine) - VMP1 gene Multispanning membrane protein in the endoplasmic reticulum (ER) required for autophagosome formation. Controls the disassociation of autophagosomes from the ER through its interaction with BECN1 and ATP2A2. Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. Required for lipoprotein secretion, involved in the release of lipoproteins from the ER membrane to the ER lumen. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (By similarity). Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death. Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity). Indicus|evm.model.CM009509.1.83 Q4R7T7 TBD_MACFA 90.508 0.995595 1.00221 TUBD1 - Tubulin delta chain - Macaca fascicularis (Crab-eating macaque) - TUBD1 gene Acts as a positive regulator of hedgehog signaling and regulates ciliary function. Indicus|evm.model.CM009509.1.84 Q6TJY3 KS6B1_BOVIN 99.810 0.996198 0.998102 RPS6KB1 - Ribosomal protein S6 kinase beta-1 - Bos taurus (Bovine) - RPS6KB1 gene Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR. Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition. Indicus|evm.model.CM009509.1.85 Q5M7Z0 RNFT1_HUMAN 89.196 0.994987 0.917241 RNFT1 - E3 ubiquitin-protein ligase RNFT1 - Homo sapiens (Human) - RNFT1 gene E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Indicus|evm.model.CM009509.1.86 Q9UHV7 MED13_HUMAN 95.771 0.98264 1.0069 MED13 - Mediator of RNA polymerase II transcription subunit 13 - Homo sapiens (Human) - MED13 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Indicus|evm.model.CM009509.1.87 Q9H0H0 INT2_HUMAN 97.012 0.998342 1.00166 INTS2 - Integrator complex subunit 2 - Homo sapiens (Human) - INTS2 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Indicus|evm.model.CM009509.1.88 Q9BX63 FANCJ_HUMAN 89.203 0.385842 0.803042 BRIP1 - Fanconi anemia group J protein - Homo sapiens (Human) - BRIP1 gene DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Indicus|evm.model.CM009509.1.89 Q9JIX0 ENY2_MOUSE 68.116 0.982759 0.574257 Eny2 - Transcription and mRNA export factor ENY2 - Mus musculus (Mouse) - Eny2 gene Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Indicus|evm.model.CM009509.1.90 P70325 TBX4_MOUSE 94.877 0.755039 1.16848 Tbx4 - T-box transcription factor TBX4 - Mus musculus (Mouse) - Tbx4 gene Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs. Indicus|evm.model.CM009509.1.91 Q863A2 TBX2_CANLF 95.932 0.996616 0.830056 TBX2 - T-box transcription factor TBX2 - Canis lupus familiaris (Dog) - TBX2 gene Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be Required for cardiac atrioventricular canal formation (By similarity). Indicus|evm.model.CM009509.1.92 Q9H6U6 BCAS3_HUMAN 96.861 0.997802 0.980603 BCAS3 - BCAS3 microtubule associated cell migration factor - Homo sapiens (Human) - BCAS3 gene Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). Indicus|evm.model.CM009509.1.93 O15297 PPM1D_HUMAN 92.401 0.961877 0.563636 PPM1D - Protein phosphatase 1D - Homo sapiens (Human) - PPM1D gene Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). Indicus|evm.model.CM009509.1.94 Q71SV0 LAP4B_BOVIN 77.876 0.98895 0.800885 LAPTM4B - Lysosomal-associated transmembrane protein 4B - Bos taurus (Bovine) - LAPTM4B gene Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. Indicus|evm.model.CM009509.1.95 O15297 PPM1D_HUMAN 78.623 0.843558 0.538843 PPM1D - Protein phosphatase 1D - Homo sapiens (Human) - PPM1D gene Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). Indicus|evm.model.CM009509.1.96 Q92624 APBP2_HUMAN 98.803 0.88351 1.12991 APPBP2 - Amyloid protein-binding protein 2 - Homo sapiens (Human) - APPBP2 gene May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. Indicus|evm.model.CM009509.1.97 Q32KP7 CQ064_BOVIN 99.573 0.954918 1.04274 Uncharacterized protein C17orf64 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009509.1.98 Q8NFA0 UBP32_HUMAN 98.462 0.941176 0.042394 USP32 - Ubiquitin carboxyl-terminal hydrolase 32 precursor - Homo sapiens (Human) - USP32 gene cytosol, Golgi apparatus, thiol-dependent deubiquitinase, protein deubiquitination Indicus|evm.model.CM009509.1.99 Q8NFA0 UBP32_HUMAN 92.950 0.865781 0.938279 USP32 - Ubiquitin carboxyl-terminal hydrolase 32 precursor - Homo sapiens (Human) - USP32 gene cytosol, Golgi apparatus, thiol-dependent deubiquitinase, protein deubiquitination Indicus|evm.model.CM009509.1.100 Q95323 CAH4_BOVIN 99.679 0.99361 1.00321 CA4 - Carbonic anhydrase 4 precursor - Bos taurus (Bovine) - CA4 gene Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity). Indicus|evm.model.CM009509.1.102 Q2KIH1 ZNHI3_BOVIN 87.709 0.987421 0.888268 ZNHIT3 - Zinc finger HIT domain-containing protein 3 - Bos taurus (Bovine) - ZNHIT3 gene cytoplasm, nucleus, pre-snoRNP complex, box C/D snoRNP assembly, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), snoRNA localization Indicus|evm.model.CM009509.1.103 Q96H55 MYO19_HUMAN 80.498 0.99789 0.97732 MYO19 - Unconventional myosin-XIX - Homo sapiens (Human) - MYO19 gene Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824). Indicus|evm.model.CM009509.1.104 Q1LZA4 PIGW_BOVIN 99.602 0.996032 1.00199 PIGW - Phosphatidylinositol-glycan biosynthesis class W protein - Bos taurus (Bovine) - PIGW gene Required for the transport of GPI-anchored proteins to the plasma membrane. Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins. Indicus|evm.model.CM009509.1.105 Q9H3C7 GGNB2_HUMAN 92.558 0.997294 1.06026 GGNBP2 - Gametogenetin-binding protein 2 - Homo sapiens (Human) - GGNBP2 gene May be involved in spermatogenesis. Indicus|evm.model.CM009509.1.106 Q3ZBV9 DHR11_BOVIN 100.000 0.767372 1.29804 DHRS11 - Dehydrogenase/reductase SDR family member 11 precursor - Bos taurus (Bovine) - DHRS11 gene Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. Indicus|evm.model.CM009509.1.107 Q99J25 MRM1_MOUSE 77.429 0.880886 1.12813 Mrm1 - rRNA methyltransferase 1, mitochondrial precursor - Mus musculus (Mouse) - Mrm1 gene S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Indicus|evm.model.CM009509.1.108 Q58DW0 RL4_BOVIN 96.445 0.995272 1.00237 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Indicus|evm.model.CM009509.1.109 Q5IS89 LHX1_SAIBB 99.754 0.995086 1.00246 LHX1 - LIM/homeobox protein Lhx1 - Saimiri boliviensis boliviensis (Bolivian squirrel monkey) - LHX1 gene Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). Indicus|evm.model.CM009509.1.110 Q9NY61 AATF_HUMAN 86.772 0.994709 1.0125 AATF - Protein AATF - Homo sapiens (Human) - AATF gene May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Indicus|evm.model.CM009509.1.112 Q9TTS3 ACACA_BOVIN 99.744 0.999148 1.00043 ACACA - Acetyl-CoA carboxylase 1 - Bos taurus (Bovine) - ACACA gene Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. Indicus|evm.model.CM009509.1.113 A6H7F9 CQ078_BOVIN 98.611 0.99308 1.01049 Uncharacterized protein C17orf78 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009509.1.114 Q3SZP8 TAD2A_BOVIN 100.000 0.995495 1.00226 TADA2A - Transcriptional adapter 2-alpha - Bos taurus (Bovine) - TADA2A gene Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. Indicus|evm.model.CM009509.1.115 Q17QM8 DUS14_BOVIN 100.000 0.98995 1.00505 DUSP14 - Dual specificity protein phosphatase 14 - Bos taurus (Bovine) - DUSP14 gene Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases (By similarity). Indicus|evm.model.CM009509.1.116 Q5SV85 SYNRG_MOUSE 92.899 0.121212 1.06126 Synrg - Synergin gamma - Mus musculus (Mouse) - Synrg gene Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (By similarity). May act by linking the adapter protein complex AP-1 to other proteins (By similarity). Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity). Indicus|evm.model.CM009509.1.117 A5D7C1 DDX52_BOVIN 100.000 0.99665 1.00168 DDX52 - Probable ATP-dependent RNA helicase DDX52 - Bos taurus (Bovine) - DDX52 gene maturation of SSU-rRNA Indicus|evm.model.CM009509.1.119 Q03365 HNF1B_PIG 97.674 0.996422 1 HNF1B - Hepatocyte nuclear factor 1-beta - Sus scrofa (Pig) - HNF1B gene Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the PFC element in the UPA gene. Indicus|evm.model.CM009509.1.121 Q5R5R2 HEAT6_PONAB 87.130 0.998308 1.00085 HEATR6 - HEAT repeat-containing protein 6 - Pongo abelii (Sumatran orangutan) - HEATR6 gene Indicus|evm.model.CM009509.1.122 P56928 ENA2_HORSE 71.429 0.0742358 9.95652 Antimicrobial peptide eNAP-2 - Equus caballus (Horse) Indicus|evm.model.CM009509.1.123 Q8SQA6 CCL3_BOVIN 69.014 0.56 1.34409 CCL3 - C-C motif chemokine 3 precursor - Bos taurus (Bovine) - CCL3 gene Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity). Indicus|evm.model.CM009509.1.124 P00993 IBP_CARCR 56.863 0.454545 1 Chelonianin - Caretta caretta (Loggerhead sea turtle) Indicus|evm.model.CM009509.1.126 Q14AE4 WFDC3_MOUSE 60.000 0.197279 1.13077 Wfdc3 - WAP four-disulfide core domain protein 3 precursor - Mus musculus (Mouse) - Wfdc3 gene extracellular space, serine-type endopeptidase inhibitor activity, antibacterial humoral response, innate immune response Indicus|evm.model.CM009509.1.127 Q17QA1 CCL4_BOVIN 100.000 0.978495 1.01087 CCL4 - C-C motif chemokine 4 precursor - Bos taurus (Bovine) - CCL4 gene Monokine with inflammatory and chemokinetic properties. Indicus|evm.model.CM009509.1.128 Q7L099 RUFY3_HUMAN 98.374 0.740181 0.705757 RUFY3 - Protein RUFY3 - Homo sapiens (Human) - RUFY3 gene Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321). Indicus|evm.model.CM009509.1.129 Q8SQA6 CCL3_BOVIN 97.826 0.968085 1.01075 CCL3 - C-C motif chemokine 3 precursor - Bos taurus (Bovine) - CCL3 gene Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity). Indicus|evm.model.CM009509.1.130 Q8SQA6 CCL3_BOVIN 78.571 0.734043 1.01075 CCL3 - C-C motif chemokine 3 precursor - Bos taurus (Bovine) - CCL3 gene Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity). Indicus|evm.model.CM009509.1.131 Q8NHW4 CC4L_HUMAN 57.377 0.655556 0.978261 CCL4L1 - C-C motif chemokine 4-like precursor - Homo sapiens (Human) - CCL4L1 gene Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. Indicus|evm.model.CM009509.1.132 P82943 REG1_BOVIN 97.826 0.978495 1.01087 Regakine-1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009509.1.133 P16619 CL3L1_HUMAN 57.143 0.421769 1.58065 CCL3L1 - C-C motif chemokine 3-like 1 precursor - Homo sapiens (Human) - CCL3L1 gene Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Indicus|evm.model.CM009509.1.134 Q16627 CCL14_HUMAN 64.894 0.978947 1.02151 CCL14 - C-C motif chemokine 14 precursor - Homo sapiens (Human) - CCL14 gene Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. Indicus|evm.model.CM009509.1.135 O15467 CCL16_HUMAN 74.194 0.891089 0.841667 CCL16 - C-C motif chemokine 16 precursor - Homo sapiens (Human) - CCL16 gene Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. Indicus|evm.model.CM009509.1.136 O97919 CCL5_BOVIN 98.901 0.978261 1.01099 CCL5 - C-C motif chemokine 5 precursor - Bos taurus (Bovine) - CCL5 gene Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Indicus|evm.model.CM009509.1.137 Q4R744 HEAT9_MACFA 67.535 0.991087 0.984211 HEATR9 - Protein HEATR9 - Macaca fascicularis (Crab-eating macaque) - HEATR9 gene Indicus|evm.model.CM009509.1.138 Q92804 RBP56_HUMAN 96.193 0.629213 1.05236 TAF15 - TATA-binding protein-associated factor 2N - Homo sapiens (Human) - TAF15 gene RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). Indicus|evm.model.CM009509.1.139 Q9H239 MMP28_HUMAN 71.702 0.99591 0.940385 MMP28 - Matrix metalloproteinase-28 precursor - Homo sapiens (Human) - MMP28 gene Can degrade casein. Could play a role in tissues homeostasis and repair. Indicus|evm.model.CM009509.1.140 Q8WW18 CQ050_HUMAN 74.269 0.944444 1.03448 C17orf50 - Uncharacterized protein C17orf50 - Homo sapiens (Human) - C17orf50 gene Indicus|evm.model.CM009509.1.141 Q8NHY3 GA2L2_HUMAN 73.182 0.997717 0.995455 GAS2L2 - GAS2-like protein 2 - Homo sapiens (Human) - GAS2L2 gene Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704). Indicus|evm.model.CM009509.1.142 Q96S79 RSLAB_HUMAN 99.507 0.990196 1.00493 RASL10B - Ras-like protein family member 10B precursor - Homo sapiens (Human) - RASL10B gene May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure. Indicus|evm.model.CM009509.1.143 Q08DS7 AP1B1_BOVIN 100.000 0.91906 0.402734 AP2B1 - AP-1 complex subunit beta-1 - Bos taurus (Bovine) - AP2B1 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). Indicus|evm.model.CM009509.1.144 P63009 AP2B1_BOVIN 100.000 0.995 0.640342 AP2B1 - AP-2 complex subunit beta - Bos taurus (Bovine) - AP2B1 gene Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly (By similarity). Indicus|evm.model.CM009509.1.145 A4FUD4 PEX12_BOVIN 100.000 0.994444 1.00279 PEX12 - Peroxisome assembly protein 12 - Bos taurus (Bovine) - PEX12 gene Required for protein import into peroxisomes. Indicus|evm.model.CM009509.1.146 P0C7P3 SLN14_HUMAN 76.586 0.997775 0.985746 SLFN14 - Protein SLFN14 - Homo sapiens (Human) - SLFN14 gene Shows no ribosome-associated and endoribonuclease activities. Indicus|evm.model.CM009509.1.147 Q7Z7L1 SLN11_HUMAN 67.964 0.982359 1.00666 SLFN11 - Schlafen family member 11 - Homo sapiens (Human) - SLFN11 gene Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900). Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900). Indicus|evm.model.CM009509.1.148 Q8IYM2 SLN12_HUMAN 61.939 0.954545 0.989619 SLFN12 - Schlafen family member 12 - Homo sapiens (Human) - SLFN12 gene Indicus|evm.model.CM009509.1.150 Q8IWX7 UN45B_HUMAN 93.770 0.997849 0.998926 UNC45B - Protein unc-45 homolog B - Homo sapiens (Human) - UNC45B gene Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development. Indicus|evm.model.CM009509.1.151 Q58D20 NLE1_BOVIN 99.588 0.995893 1.00206 NLE1 - Notchless protein homolog 1 - Bos taurus (Bovine) - NLE1 gene Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). Indicus|evm.model.CM009509.1.152 Q2YDH8 FNDC8_BOVIN 99.688 0.993789 1.00312 FNDC8 - Fibronectin type III domain-containing protein 8 - Bos taurus (Bovine) - FNDC8 gene Indicus|evm.model.CM009509.1.153 Q2HJ51 RA51D_BOVIN 99.693 0.993884 1.00307 RAD51D - DNA repair protein RAD51 homolog 4 - Bos taurus (Bovine) - RAD51D gene Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM (By similarity). Indicus|evm.model.CM009509.1.154 Q8WZ73 RFFL_HUMAN 87.052 0.96206 1.01653 RFFL - E3 ubiquitin-protein ligase rififylin - Homo sapiens (Human) - RFFL gene E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. Indicus|evm.model.CM009509.1.155 P49916 DNLI3_HUMAN 87.697 0.998006 0.994054 LIG3 - DNA ligase 3 precursor - Homo sapiens (Human) - LIG3 gene Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). Indicus|evm.model.CM009509.1.156 Q96NB3 ZN830_HUMAN 86.327 0.994652 1.00538 ZNF830 - Zinc finger protein 830 - Homo sapiens (Human) - ZNF830 gene May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity). Indicus|evm.model.CM009509.1.157 Q3T084 TCPW_BOVIN 99.435 0.996241 1.00188 CCT6B - T-complex protein 1 subunit zeta-2 - Bos taurus (Bovine) - CCT6B gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. Indicus|evm.model.CM009509.1.158 Q6IEE7 T132E_HUMAN 95.338 0.984977 0.99162 TMEM132E - Transmembrane protein 132E precursor - Homo sapiens (Human) - TMEM132E gene Required for normal inner ear hair cell function and hearing. Indicus|evm.model.CM009509.1.161 P22362 CCL1_HUMAN 58.621 0.876923 0.677083 CCL1 - C-C motif chemokine 1 precursor - Homo sapiens (Human) - CCL1 gene Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Indicus|evm.model.CM009509.1.162 Q09141 CCL8_BOVIN 100.000 0.98 1.0101 CCL8 - C-C motif chemokine 8 precursor - Bos taurus (Bovine) - CCL8 gene Chemotactic factor that attracts monocytes. This protein can bind heparin. Indicus|evm.model.CM009509.1.163 Q9TTS6 CCL11_BOVIN 100.000 0.979592 1.01031 CCL11 - Eotaxin precursor - Bos taurus (Bovine) - CCL11 gene In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils (Probable). Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary (PubMed:15916812). Binds to CCR3 (By similarity). Indicus|evm.model.CM009509.1.164 P28291 CCL2_BOVIN 98.990 0.98 1.0101 CCL2 - C-C motif chemokine 2 precursor - Bos taurus (Bovine) - CCL2 gene Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Indicus|evm.model.CM009509.1.165 Q62962 ASIC2_RAT 96.335 0.974093 0.376953 Asic2 - Acid-sensing ion channel 2 - Rattus norvegicus (Rat) - Asic2 gene Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Activation by an extracellular pH drop is followed by a rapid pH-independent inactivation. Heteromeric channel assembly seems to modulate channel properties. Indicus|evm.model.CM009509.1.168 Q925H0 ASIC2_MOUSE 92.966 0.958861 0.617188 Asic2 - Acid-sensing ion channel 2 - Mus musculus (Mouse) - Asic2 gene Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Indicus|evm.model.CM009509.1.169 A6QQ77 SACA3_BOVIN 100.000 0.838983 0.723926 SPACA3 - Sperm acrosome membrane-associated protein 3 precursor - Bos taurus (Bovine) - SPACA3 gene Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro (By similarity). Indicus|evm.model.CM009509.1.170 Q2HJB9 TMM98_BOVIN 99.558 0.991189 1.00442 TMEM98 - Transmembrane protein 98 - Bos taurus (Bovine) - TMEM98 gene Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). Indicus|evm.model.CM009509.1.171 Q17R14 MYO1D_BOVIN 99.705 0.774857 0.869781 MYO1D - Unconventional myosin-Id - Bos taurus (Bovine) - MYO1D gene Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). Indicus|evm.model.CM009509.1.173 Q17R14 MYO1D_BOVIN 100.000 0.689189 0.0735586 MYO1D - Unconventional myosin-Id - Bos taurus (Bovine) - MYO1D gene Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). Indicus|evm.model.CM009509.1.174 Q28199 CD5R1_BOVIN 100.000 0.993506 1.00326 CDK5R1 - Cyclin-dependent kinase 5 activator 1 precursor - Bos taurus (Bovine) - CDK5R1 gene p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity). Indicus|evm.model.CM009509.1.175 F1LMZ8 PSD11_RAT 100.000 0.995272 1.00237 Psmd11 - 26S proteasome non-ATPase regulatory subunit 11 - Rattus norvegicus (Rat) - Psmd11 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Indicus|evm.model.CM009509.1.176 Q5R8K4 ZN207_PONAB 98.785 0.99596 1.00202 ZNF207 - BUB3-interacting and GLEBS motif-containing protein ZNF207 - Pongo abelii (Sumatran orangutan) - ZNF207 gene Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome. Indicus|evm.model.CM009509.1.177 Q9HAS0 NJMU_HUMAN 88.957 0.942029 0.871212 C17orf75 - Protein Njmu-R1 - Homo sapiens (Human) - C17orf75 gene As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. Indicus|evm.model.CM009509.1.178 P58872 RHBL3_HUMAN 97.493 0.99169 0.893564 RHBDL3 - Rhomboid-related protein 3 - Homo sapiens (Human) - RHBDL3 gene May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Indicus|evm.model.CM009509.1.179 Q2HJF8 MIRO1_BOVIN 93.778 0.99697 1.04596 RHOT1 - Mitochondrial Rho GTPase 1 - Bos taurus (Bovine) - RHOT1 gene Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). Indicus|evm.model.CM009509.1.180 Q8IUD6 RN135_HUMAN 64.368 0.995294 0.983796 RNF135 - E3 ubiquitin-protein ligase RNF135 - Homo sapiens (Human) - RNF135 gene E2-dependent E3 ubiquitin-protein ligase that functions as a RIG-I/DDX58 coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIG-I/DDX58 filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (PubMed:28469175, PubMed:31006531). Indicus|evm.model.CM009509.1.181 Q9NPF8 ADAP2_HUMAN 86.614 0.994667 0.984252 ADAP2 - Arf-GAP with dual PH domain-containing protein 2 - Homo sapiens (Human) - ADAP2 gene GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. Indicus|evm.model.CM009509.1.182 A6QPR9 TEFM_BOVIN 100.000 0.98338 1.01404 TEFM - Transcription elongation factor, mitochondrial precursor - Bos taurus (Bovine) - TEFM gene Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery (By similarity). Indicus|evm.model.CM009509.1.183 Q96QE3 ATAD5_HUMAN 74.974 0.998944 1.02711 ATAD5 - ATPase family AAA domain-containing protein 5 - Homo sapiens (Human) - ATAD5 gene Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis. Indicus|evm.model.CM009509.1.184 Q8IUI8 CRLF3_HUMAN 95.785 0.970387 0.993213 CRLF3 - Cytokine receptor-like factor 3 - Homo sapiens (Human) - CRLF3 gene May play a role in the negative regulation of cell cycle progression. Indicus|evm.model.CM009509.1.185 Q15022 SUZ12_HUMAN 99.188 0.997297 1.00135 SUZ12 - Polycomb protein SUZ12 - Homo sapiens (Human) - SUZ12 gene Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). Indicus|evm.model.CM009509.1.186 Q8VCY6 UTP6_MOUSE 75.168 0.993322 1.00335 Utp6 - U3 small nucleolar RNA-associated protein 6 homolog - Mus musculus (Mouse) - Utp6 gene Involved in nucleolar processing of pre-18S ribosomal RNA. Indicus|evm.model.CM009509.1.187 A5PJD3 COPRS_BOVIN 100.000 0.989247 1.00541 COPRS - Coordinator of PRMT5 and differentiation stimulator - Bos taurus (Bovine) - COPRS gene Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). Indicus|evm.model.CM009509.1.188 Q86YS3 RFIP4_HUMAN 94.692 0.925397 0.989011 RAB11FIP4 - Rab11 family-interacting protein 4 - Homo sapiens (Human) - RAB11FIP4 gene Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. Indicus|evm.model.CM009509.1.189 P21359 NF1_HUMAN 99.261 0.41219 0.924621 NF1 - Neurofibromin - Homo sapiens (Human) - NF1 gene Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. Indicus|evm.model.CM009509.1.190 Q9Y6I7 WSB1_HUMAN 97.862 0.995261 1.00238 WSB1 - WD repeat and SOCS box-containing protein 1 - Homo sapiens (Human) - WSB1 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. Indicus|evm.model.CM009509.1.191 Q61097 KSR1_MOUSE 89.157 0.491018 0.191294 Ksr1 - Kinase suppressor of Ras 1 - Mus musculus (Mouse) - Ksr1 gene Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (PubMed:10409742, PubMed:12932319, PubMed:21102438, PubMed:21441104). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (By similarity). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (PubMed:21102438). Its kinase activity is unsure (PubMed:21441104). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (PubMed:21441104). Indicus|evm.model.CM009509.1.192 Q8IVT5 KSR1_HUMAN 87.234 0.326241 0.152763 KSR1 - Kinase suppressor of Ras 1 - Homo sapiens (Human) - KSR1 gene Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). Indicus|evm.model.CM009509.1.193 Q8IVT5 KSR1_HUMAN 90.683 0.95716 0.885157 KSR1 - Kinase suppressor of Ras 1 - Homo sapiens (Human) - KSR1 gene Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). Indicus|evm.model.CM009509.1.195 Q3MHZ8 LEG9_BOVIN 99.718 0.994382 1.00282 LGALS9 - Galectin-9 - Bos taurus (Bovine) - LGALS9 gene Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth. Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function. Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation. Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection. Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells. Inhibits degranulation and induces apoptosis of mast cells. Induces maturation and migration of dendritic cells. Inhibits natural killer (NK) cell function. Can transform NK cell phenotype from peripheral to decidual during pregnancy. Astrocyte derived galectin-9 enhances microglial TNF production. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Highly selective to the anion urate. Indicus|evm.model.CM009509.1.196 Q27995 NOS2_BOVIN 99.911 0.968858 1 NOS2 - Nitric oxide synthase, inducible - Bos taurus (Bovine) - NOS2 gene Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8. Indicus|evm.model.CM009509.1.198 Q9BZM4 ULBP3_HUMAN 48.515 0.813008 0.504098 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Indicus|evm.model.CM009509.1.201 Q9BZM5 ULBP2_HUMAN 48.913 0.618243 1.20325 ULBP2 - UL16-binding protein 2 precursor - Homo sapiens (Human) - ULBP2 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Indicus|evm.model.CM009509.1.202 A5D7J1 LYRM9_BOVIN 98.630 0.808989 1.14103 LYRM9 - LYR motif-containing protein 9 - Bos taurus (Bovine) - LYRM9 gene Indicus|evm.model.CM009509.1.204 Q98TF8 RL22_CHICK 82.759 0.924731 0.726562 RPL22 - 60S ribosomal protein L22 - Gallus gallus (Chicken) - RPL22 gene RNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009509.1.205 Q9UBE8 NLK_HUMAN 100.000 0.996212 1.0019 NLK - Serine/threonine-protein kinase NLK - Homo sapiens (Human) - NLK gene Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613). Indicus|evm.model.CM009509.1.207 Q3MHW7 SGMR2_BOVIN 100.000 0.988701 1.00568 TMEM97 - Sigma intracellular receptor 2 - Bos taurus (Bovine) - TMEM97 gene Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. Indicus|evm.model.CM009509.1.208 Q58CS6 IFT20_BOVIN 99.359 0.987261 1.00641 IFT20 - Intraflagellar transport protein 20 homolog - Bos taurus (Bovine) - IFT20 gene Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling. Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. Indicus|evm.model.CM009509.1.209 Q13829 BACD2_HUMAN 98.101 0.993691 1.00316 TNFAIP1 - BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 - Homo sapiens (Human) - TNFAIP1 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Indicus|evm.model.CM009509.1.210 Q9Y2S7 PDIP2_HUMAN 97.283 0.99458 1.00272 POLDIP2 - Polymerase delta-interacting protein 2 precursor - Homo sapiens (Human) - POLDIP2 gene Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527). Indicus|evm.model.CM009509.1.211 Q8N511 TM199_HUMAN 92.788 0.990291 0.990385 TMEM199 - Transmembrane protein 199 - Homo sapiens (Human) - TMEM199 gene Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833330). Indicus|evm.model.CM009509.1.212 Q9HB31 SEBOX_HUMAN 71.579 0.989529 1.00526 SEBOX - Homeobox protein SEBOX - Homo sapiens (Human) - SEBOX gene Probable transcription factor involved in the control of specification of mesoderm and endoderm. Indicus|evm.model.CM009509.1.213 P04004 VTNC_HUMAN 71.800 0.953878 0.997908 VTN - Vitronectin precursor - Homo sapiens (Human) - VTN gene Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Indicus|evm.model.CM009509.1.214 Q6SZW1 SARM1_HUMAN 93.776 0.990398 1.00691 SARM1 - NAD(+) hydrolase SARM1 precursor - Homo sapiens (Human) - SARM1 gene NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:32049506, PubMed:32828421, PubMed:31439792, PubMed:33053563). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). Indicus|evm.model.CM009509.1.215 Q05B81 PCFT_BOVIN 99.564 0.995652 1.00218 SLC46A1 - Proton-coupled folate transporter - Bos taurus (Bovine) - SLC46A1 gene Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. Indicus|evm.model.CM009509.1.216 A8D8X1 RL10_SHEEP 76.712 0.972973 0.345794 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009509.1.217 Q9ES88 S13A2_MOUSE 77.414 0.971332 1.01195 Slc13a2 - Solute carrier family 13 member 2 - Mus musculus (Mouse) - Slc13a2 gene Cotransport of sodium ions and dicarboxylates such as succinate and citrate. Indicus|evm.model.CM009509.1.218 O15353 FOXN1_HUMAN 90.293 0.92 1.08025 FOXN1 - Forkhead box protein N1 - Homo sapiens (Human) - FOXN1 gene Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891). Indicus|evm.model.CM009509.1.219 Q3SYR2 U119A_BOVIN 100.000 0.991701 1.00417 UNC119 - Protein unc-119 homolog A - Bos taurus (Bovine) - UNC119 gene Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A (By similarity). Indicus|evm.model.CM009509.1.220 Q3SZL5 PIGS_BOVIN 100.000 0.996403 1.0018 PIGS - GPI transamidase component PIG-S - Bos taurus (Bovine) - PIGS gene Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (By similarity). Indicus|evm.model.CM009509.1.221 Q9GKW3 ALDOC_MACFA 98.901 0.994521 1.00275 ALDOC - Fructose-bisphosphate aldolase C - Macaca fascicularis (Crab-eating macaque) - ALDOC gene fructose-bisphosphate aldolase activity, fructose 1,6-bisphosphate metabolic process Indicus|evm.model.CM009509.1.222 Q96R06 SPAG5_HUMAN 77.926 0.998325 1.00084 SPAG5 - Sperm-associated antigen 5 - Homo sapiens (Human) - SPAG5 gene Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). Indicus|evm.model.CM009509.1.223 Q96LW2 KS6R_HUMAN 85.539 0.987685 0.990244 RSKR - Ribosomal protein S6 kinase-related protein - Homo sapiens (Human) - RSKR gene Indicus|evm.model.CM009509.1.224 Q3SZ45 SDF2_BOVIN 99.497 0.0818182 11.4692 SDF2 - Stromal cell-derived factor 2 precursor - Bos taurus (Bovine) - SDF2 gene Indicus|evm.model.CM009509.1.225 Q7KZ85 SPT6H_HUMAN 98.899 0.998842 1.00058 SUPT6H - Transcription elongation factor SPT6 - Homo sapiens (Human) - SUPT6H gene Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. Indicus|evm.model.CM009509.1.226 A7E371 PRCA1_BOVIN 100.000 0.994695 1.00266 PROCA1 - Protein PROCA1 - Bos taurus (Bovine) - PROCA1 gene Indicus|evm.model.CM009509.1.227 Q9BZG1 RAB34_HUMAN 75.290 0.990476 0.810811 RAB34 - Ras-related protein Rab-34 - Homo sapiens (Human) - RAB34 gene Transport protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:27113757). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity). Indicus|evm.model.CM009509.1.228 P62752 RL23A_RAT 100.000 0.987261 1.00641 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009509.1.229 Q96CP7 TLCD1_HUMAN 89.316 0.939516 1.00405 TLCD1 - TLC domain-containing protein 1 precursor - Homo sapiens (Human) - TLCD1 gene Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349). Indicus|evm.model.CM009509.1.230 Q86SG6 NEK8_HUMAN 94.126 0.997139 1.01012 NEK8 - Serine/threonine-protein kinase Nek8 - Homo sapiens (Human) - NEK8 gene Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. Indicus|evm.model.CM009509.1.231 Q9BUZ4 TRAF4_HUMAN 98.085 0.995754 1.00213 TRAF4 - TNF receptor-associated factor 4 - Homo sapiens (Human) - TRAF4 gene Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Indicus|evm.model.CM009509.1.232 Q8WU58 F222B_HUMAN 95.915 0.996454 1.00356 FAM222B - Protein FAM222B - Homo sapiens (Human) - FAM222B gene nucleoplasm Indicus|evm.model.CM009509.1.233 A5PK43 ERAL1_BOVIN 100.000 0.995434 1.00229 ERAL1 - GTPase Era, mitochondrial precursor - Bos taurus (Bovine) - ERAL1 gene Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity). Indicus|evm.model.CM009509.1.234 A6QLR4 FLOT2_BOVIN 100.000 0.487277 1.83645 FLOT2 - Flotillin-2 - Bos taurus (Bovine) - FLOT2 gene May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function (By similarity). Indicus|evm.model.CM009509.1.235 Q96QT6 PHF12_HUMAN 97.211 0.99801 1.001 PHF12 - PHD finger protein 12 - Homo sapiens (Human) - PHF12 gene Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA. Indicus|evm.model.CM009509.1.236 A0JNA2 SEZ6_BOVIN 99.486 0.98881 1 SEZ6 - Seizure protein 6 homolog precursor - Bos taurus (Bovine) - SEZ6 gene May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity). Indicus|evm.model.CM009509.1.237 Q29RU9 SOX_BOVIN 98.469 0.994911 1.00255 PIPOX - Peroxisomal sarcosine oxidase - Bos taurus (Bovine) - PIPOX gene Metabolizes sarcosine, L-pipecolic acid and L-proline. Indicus|evm.model.CM009509.1.238 Q92614 MY18A_HUMAN 82.143 0.639535 0.0418695 MYO18A - Unconventional myosin-XVIIIa - Homo sapiens (Human) - MYO18A gene May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). Indicus|evm.model.CM009509.1.239 Q92614 MY18A_HUMAN 97.433 0.351394 1.24002 MYO18A - Unconventional myosin-XVIIIa - Homo sapiens (Human) - MYO18A gene May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). Indicus|evm.model.CM009509.1.240 P11843 CRBA1_BOVIN 100.000 0.990741 1.00465 CRYBA1 - Beta-crystallin A3 - Bos taurus (Bovine) - CRYBA1 gene Crystallins are the dominant structural components of the vertebrate eye lens. Indicus|evm.model.CM009509.1.241 Q7Z417 NUFP2_HUMAN 95.455 0.944126 1.00432 NUFIP2 - Nuclear fragile X mental retardation-interacting protein 2 - Homo sapiens (Human) - NUFIP2 gene Binds RNA. Indicus|evm.model.CM009509.1.242 Q7L7X3 TAOK1_HUMAN 99.700 0.998004 1.001 TAOK1 - Serine/threonine-protein kinase TAO1 - Homo sapiens (Human) - TAOK1 gene Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Indicus|evm.model.CM009509.1.243 Q6UXT9 ABH15_HUMAN 89.744 0.956967 1.04274 ABHD15 - Protein ABHD15 precursor - Homo sapiens (Human) - ABHD15 gene membrane, acylglycerol lipase activity, short-chain carboxylesterase activity, cellular lipid metabolic process Indicus|evm.model.CM009509.1.244 Q8NBR0 P5I13_HUMAN 76.267 0.944444 1.00763 TP53I13 - Tumor protein p53-inducible protein 13 precursor - Homo sapiens (Human) - TP53I13 gene May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed. Indicus|evm.model.CM009509.1.245 Q9Y2X7 GIT1_HUMAN 98.387 0.991989 0.984231 GIT1 - ARF GTPase-activating protein GIT1 - Homo sapiens (Human) - GIT1 gene GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). Indicus|evm.model.CM009509.1.246 Q86YJ7 AN13B_HUMAN 97.129 0.973561 1.02716 ANKRD13B - Ankyrin repeat domain-containing protein 13B - Homo sapiens (Human) - ANKRD13B gene Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. Indicus|evm.model.CM009509.1.247 Q920J3 CORO6_RAT 95.551 0.241397 4.125 Coro6 - Coronin-6 - Rattus norvegicus (Rat) - Coro6 gene actin filament binding, actin filament organization, cell migration Indicus|evm.model.CM009509.1.249 A4FU69 EFCB5_HUMAN 69.830 0.998675 1.00466 EFCAB5 - EF-hand calcium-binding domain-containing protein 5 - Homo sapiens (Human) - EFCAB5 gene Indicus|evm.model.CM009509.1.250 Q2KIC0 NSRP1_BOVIN 99.642 0.996429 1.00179 NSRP1 - Nuclear speckle splicing regulatory protein 1 - Bos taurus (Bovine) - NSRP1 gene RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Indicus|evm.model.CM009509.1.251 Q9XT49 SC6A4_BOVIN 100.000 0.99683 1.00159 SLC6A4 - Sodium-dependent serotonin transporter - Bos taurus (Bovine) - SLC6A4 gene Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Indicus|evm.model.CM009509.1.252 P70645 BLMH_RAT 94.457 0.978261 1.01322 Blmh - Bleomycin hydrolase - Rattus norvegicus (Rat) - Blmh gene The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics. Indicus|evm.model.CM009509.1.253 Q3T113 TMIG1_BOVIN 99.617 0.992366 1.00383 TMIGD1 - Transmembrane and immunoglobulin domain-containing protein 1 precursor - Bos taurus (Bovine) - TMIGD1 gene May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival. Indicus|evm.model.CM009509.1.254 O75976 CBPD_HUMAN 86.661 0.902813 0.85 CPD - Carboxypeptidase D precursor - Homo sapiens (Human) - CPD gene extracellular exosome, extracellular space, membrane, metallocarboxypeptidase activity, serine-type carboxypeptidase activity, peptide metabolic process, protein processing Indicus|evm.model.CM009509.1.255 Q9JHW1 CBPD_RAT 97.561 0.991903 0.179245 Cpd - Carboxypeptidase D precursor - Rattus norvegicus (Rat) - Cpd gene extracellular space, integral component of membrane, intracellular membrane-bounded organelle, nucleus, perinuclear region of cytoplasm, trans-Golgi network, metallocarboxypeptidase activity, protein phosphatase 2A binding, protein-containing complex binding, zinc ion binding Indicus|evm.model.CM009509.1.256 Q2TBU3 GOSR1_BOVIN 99.583 0.929961 1.028 GOSR1 - Golgi SNAP receptor complex member 1 - Bos taurus (Bovine) - GOSR1 gene Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity). Indicus|evm.model.CM009509.1.257 Q2MHH0 TARG1_RAT 77.457 0.966292 1.0289 Trarg1 - Trafficking regulator of GLUT4 1 - Rattus norvegicus (Rat) - Trarg1 gene Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. Indicus|evm.model.CM009509.1.258 Q7RTU4 BHA09_HUMAN 76.923 0.515556 0.957447 BHLHA9 - Class A basic helix-loop-helix protein 9 - Homo sapiens (Human) - BHLHA9 gene Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis. Indicus|evm.model.CM009509.1.259 Q6PAJ1 BCR_MOUSE 46.154 0.16285 0.309449 Bcr - Breakpoint cluster region protein - Mus musculus (Mouse) - Bcr gene Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (PubMed:20962234). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (By similarity). Indicus|evm.model.CM009509.1.260 A6QNS3 ABR_BOVIN 100.000 0.997674 1.00116 ABR - Active breakpoint cluster region-related protein - Bos taurus (Bovine) - ABR gene Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). Indicus|evm.model.CM009509.1.261 Q5BIN4 TIM22_BOVIN 100.000 0.989744 1.00515 TIMM22 - Mitochondrial import inner membrane translocase subunit Tim22 - Bos taurus (Bovine) - TIMM22 gene Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). Indicus|evm.model.CM009509.1.262 A6QLU8 NXN_BOVIN 100.000 0.813472 0.887356 NXN - Nucleoredoxin - Bos taurus (Bovine) - NXN gene Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). Indicus|evm.model.CM009509.1.263 Q9HC36 MRM3_HUMAN 84.915 0.987923 0.985714 MRM3 - rRNA methyltransferase 3, mitochondrial precursor - Homo sapiens (Human) - MRM3 gene S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Indicus|evm.model.CM009509.1.264 Q9CPV4 GLOD4_MOUSE 83.221 0.993311 1.00336 Glod4 - Glyoxalase domain-containing protein 4 - Mus musculus (Mouse) - Glod4 gene mitochondrion Indicus|evm.model.CM009509.1.265 P57678 GEMI4_HUMAN 85.038 0.978664 1.0189 GEMIN4 - Gem-associated protein 4 - Homo sapiens (Human) - GEMIN4 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Indicus|evm.model.CM009509.1.266 Q8TBR7 TLC3A_HUMAN 80.620 0.992278 1.00778 TLCD3A - TLC domain-containing protein 3A - Homo sapiens (Human) - TLCD3A gene endoplasmic reticulum, plasma membrane, lipid homeostasis Indicus|evm.model.CM009509.1.267 Q5R5J4 VPS53_PONAB 97.837 0.997599 1.0012 VPS53 - Vacuolar protein sorting-associated protein 53 homolog - Pongo abelii (Sumatran orangutan) - VPS53 gene Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Indicus|evm.model.CM009509.1.269 Q8N5W9 RFLB_HUMAN 84.783 0.769663 0.831776 RFLNB - Refilin-B - Homo sapiens (Human) - RFLNB gene Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. Indicus|evm.model.CM009509.1.270 Q6ZQX7 LIAT1_HUMAN 64.319 0.825911 0.545254 LIAT1 - Protein LIAT1 - Homo sapiens (Human) - LIAT1 gene May be involved in ATE1-mediated N-terminal arginylation. Indicus|evm.model.CM009509.1.271 Q58D79 RPH3L_BOVIN 100.000 0.481788 2.06849 RPH3AL - Rab effector Noc2 - Bos taurus (Bovine) - RPH3AL gene Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Indicus|evm.model.CM009509.1.272 P62262 1433E_SHEEP 100.000 0.992188 1.00392 YWHAE - 14-3-3 protein epsilon - Ovis aries (Sheep) - YWHAE gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Indicus|evm.model.CM009509.1.273 P46108 CRK_HUMAN 100.000 0.993443 1.00329 CRK - Adapter molecule crk - Homo sapiens (Human) - CRK gene Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Indicus|evm.model.CM009509.1.274 Q27966 MYO1C_BOVIN 100.000 0.99812 1.00094 MYO1C - Unconventional myosin-Ic - Bos taurus (Bovine) - MYO1C gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity). Indicus|evm.model.CM009509.1.275 Q9BT40 INP5K_HUMAN 78.619 0.988889 1.00446 INPP5K - Inositol polyphosphate 5-phosphatase K - Homo sapiens (Human) - INPP5K gene Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PubMed:10753883, PubMed:16824732). Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity). Indicus|evm.model.CM009509.1.276 Q2HJ54 PIPNA_BOVIN 100.000 0.99262 1.0037 PITPNA - Phosphatidylinositol transfer protein alpha isoform - Bos taurus (Bovine) - PITPNA gene Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:7654206). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity). Indicus|evm.model.CM009509.1.277 Q0VCM6 LAT4_BOVIN 99.824 0.815827 1.22359 SLC43A2 - Large neutral amino acids transporter small subunit 4 - Bos taurus (Bovine) - SLC43A2 gene Sodium-, chloride, pH-independent high affinity transport of large neutral amino acids. Indicus|evm.model.CM009509.1.278 Q14162 SREC_HUMAN 71.446 0.979543 1.0012 SCARF1 - Scavenger receptor class F member 1 precursor - Homo sapiens (Human) - SCARF1 gene Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). Indicus|evm.model.CM009509.1.279 Q96NA2 RILP_HUMAN 78.307 0.959288 0.98005 RILP - Rab-interacting lysosomal protein - Homo sapiens (Human) - RILP gene Rab effector playing a role in late endocytic transport to degradative compartments (PubMed:11696325, PubMed:14668488, PubMed:27113757, PubMed:11179213, PubMed:12944476). Involved in the regulation of lysosomal morphology and distribution (PubMed:14668488, PubMed:27113757). Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments (PubMed:11179213, PubMed:11696325). Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (PubMed:12944476). Indicus|evm.model.CM009509.1.280 Q6P2Q9 PRP8_HUMAN 100.000 0.901506 1.10878 PRPF8 - Pre-mRNA-processing-splicing factor 8 - Homo sapiens (Human) - PRPF8 gene Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. Indicus|evm.model.CM009509.1.281 Q562E7 WDR81_HUMAN 89.134 0.998973 1.00361 WDR81 - WD repeat-containing protein 81 - Homo sapiens (Human) - WDR81 gene Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). Indicus|evm.model.CM009509.1.282 P28800 A2AP_BOVIN 99.593 0.995943 1.00203 SERPINF2 - Alpha-2-antiplasmin precursor - Bos taurus (Bovine) - SERPINF2 gene Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity). Indicus|evm.model.CM009509.1.283 Q95121 PEDF_BOVIN 100.000 0.995204 1.0024 SERPINF1 - Pigment epithelium-derived factor precursor - Bos taurus (Bovine) - SERPINF1 gene Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Indicus|evm.model.CM009509.1.284 Q8IYR2 SMYD4_HUMAN 74.595 0.995019 0.998756 SMYD4 - SET and MYND domain-containing protein 4 - Homo sapiens (Human) - SMYD4 gene Indicus|evm.model.CM009509.1.285 P27694 RFA1_HUMAN 90.097 0.996759 1.00162 RPA1 - Replication protein A 70 kDa DNA-binding subunit - Homo sapiens (Human) - RPA1 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:27723720, PubMed:27723717). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance (PubMed:17959650). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). Indicus|evm.model.CM009509.1.286 Q8K0S5 R4RL1_MOUSE 90.807 0.995526 1.00449 Rtn4rl1 - Reticulon-4 receptor-like 1 precursor - Mus musculus (Mouse) - Rtn4rl1 gene Cell surface receptor that plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system (PubMed:22406547, PubMed:27339102). Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans (PubMed:22406547). Binds heparin (PubMed:22406547). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Indicus|evm.model.CM009509.1.287 Q3SYT1 DPH1_BOVIN 100.000 0.995444 1.00228 DPH1 - 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 - Bos taurus (Bovine) - DPH1 gene Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. Indicus|evm.model.CM009509.1.288 Q3SZ07 OVCA2_BOVIN 100.000 0.991228 1.00441 OVCA2 - Esterase OVCA2 - Bos taurus (Bovine) - OVCA2 gene cytoplasm, nucleus, response to retinoic acid Indicus|evm.model.CM009509.1.289 Q14526 HIC1_HUMAN 99.296 0.198592 0.968622 HIC1 - Hypermethylated in cancer 1 protein - Homo sapiens (Human) - HIC1 gene Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). Indicus|evm.model.CM009509.1.290 Q5RAK6 EST1A_PONAB 92.898 0.980184 0.995772 SMG6 - Telomerase-binding protein EST1A - Pongo abelii (Sumatran orangutan) - SMG6 gene Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). Indicus|evm.model.CM009509.1.291 A0JNI4 SRR_BOVIN 99.701 0.99403 1.00299 SRR - Serine racemase - Bos taurus (Bovine) - SRR gene Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity). Indicus|evm.model.CM009509.1.292 Q2NL82 TSR1_HUMAN 89.950 0.997516 1.00124 TSR1 - Pre-rRNA-processing protein TSR1 homolog - Homo sapiens (Human) - TSR1 gene Required during maturation of the 40S ribosomal subunit in the nucleolus. Indicus|evm.model.CM009509.1.293 O43147 SGSM2_HUMAN 87.167 0.998095 1.04374 SGSM2 - Small G protein signaling modulator 2 - Homo sapiens (Human) - SGSM2 gene Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560). Indicus|evm.model.CM009509.1.294 Q99583 MNT_HUMAN 87.331 0.99654 0.993127 MNT - Max-binding protein MNT - Homo sapiens (Human) - MNT gene Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. Indicus|evm.model.CM009509.1.295 Q86W50 MET16_HUMAN 91.071 0.852134 1.16726 METTL16 - RNA N6-adenosine-methyltransferase METTL16 - Homo sapiens (Human) - METTL16 gene RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). Indicus|evm.model.CM009509.1.296 P63004 LIS1_RAT 100.000 0.940898 1.03171 Pafah1b1 - Platelet-activating factor acetylhydrolase IB subunit alpha - Rattus norvegicus (Rat) - Pafah1b1 gene Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates to the PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (By similarity). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). Indicus|evm.model.CM009509.1.297 O75153 CLU_HUMAN 95.271 0.97037 1.03132 CLUH - Clustered mitochondria protein homolog - Homo sapiens (Human) - CLUH gene mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. Indicus|evm.model.CM009509.1.299 Q684P5 RPGP2_HUMAN 97.436 0.405263 0.260274 RAP1GAP2 - Rap1 GTPase-activating protein 2 - Homo sapiens (Human) - RAP1GAP2 gene GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. Indicus|evm.model.CM009509.1.300 Q9TU84 OR1D2_PONPY 72.727 0.970297 0.322684 OR1D2 - Olfactory receptor 1D2 - Pongo pygmaeus (Bornean orangutan) - OR1D2 gene Odorant receptor. Indicus|evm.model.CM009509.1.301 Q5E983 EF1B_BOVIN 58.667 0.933333 0.8 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Indicus|evm.model.CM009509.1.302 Q8NGR3 OR1K1_HUMAN 50.549 0.638298 0.446203 OR1K1 - Olfactory receptor 1K1 - Homo sapiens (Human) - OR1K1 gene Odorant receptor. Indicus|evm.model.CM009509.1.304 Q2TA20 SPT22_BOVIN 99.451 0.994521 1.00275 SPATA22 - Spermatogenesis-associated protein 22 - Bos taurus (Bovine) - SPATA22 gene Meiosis-specific protein required for homologous recombination in meiosis I. Indicus|evm.model.CM009509.1.305 P46446 ACY2_BOVIN 99.361 0.993631 1.00319 ASPA - Aspartoacylase - Bos taurus (Bovine) - ASPA gene Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity). Indicus|evm.model.CM009509.1.306 Q8NET8 TRPV3_HUMAN 94.058 0.480828 2.07975 TRPV3 - Transient receptor potential cation channel subfamily V member 3 - Homo sapiens (Human) - TRPV3 gene Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). Indicus|evm.model.CM009509.1.307 Q9UHJ6 SHPK_HUMAN 87.029 0.995825 1.00209 SHPK - Sedoheptulokinase - Homo sapiens (Human) - SHPK gene Acts as a modulator of macrophage activation through control of glucose metabolism. Indicus|evm.model.CM009509.1.308 A7MB63 CTNS_BOVIN 99.455 0.994565 1.00272 CTNS - Cystinosin precursor - Bos taurus (Bovine) - CTNS gene Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity. Indicus|evm.model.CM009509.1.309 O14907 TX1B3_HUMAN 99.194 0.984 1.00806 TAX1BP3 - Tax1-binding protein 3 - Homo sapiens (Human) - TAX1BP3 gene May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. Indicus|evm.model.CM009509.1.310 Q9CQW0 EMC6_MOUSE 99.091 0.981982 1.00909 Emc6 - ER membrane protein complex subunit 6 - Mus musculus (Mouse) - Emc6 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Indicus|evm.model.CM009509.1.311 Q93086 P2RX5_HUMAN 67.202 0.736014 1.35545 P2RX5 - P2X purinoceptor 5 - Homo sapiens (Human) - P2RX5 gene Receptor for ATP that acts as a ligand-gated ion channel. Indicus|evm.model.CM009509.1.312 Q2KIP2 HASP_BOVIN 98.976 0.997442 1.00128 HASPIN - Serine/threonine-protein kinase haspin - Bos taurus (Bovine) - HASPIN gene Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. Indicus|evm.model.CM009509.1.313 P38570 ITAE_HUMAN 71.973 0.962818 0.866836 ITGAE - Integrin alpha-E precursor - Homo sapiens (Human) - ITGAE gene Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Indicus|evm.model.CM009509.1.314 Q53F19 NCBP3_HUMAN 93.069 0.973813 0.985484 NCBP3 - Nuclear cap-binding protein subunit 3 - Homo sapiens (Human) - NCBP3 gene Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). Indicus|evm.model.CM009509.1.316 Q8N5S9 KKCC1_HUMAN 90.099 0.550741 1.73663 CAMKK1 - Calcium/calmodulin-dependent protein kinase kinase 1 - Homo sapiens (Human) - CAMKK1 gene Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. Indicus|evm.model.CM009509.1.317 O77696 AT2A3_PIG 96.096 0.998 1.001 ATP2A3 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 - Sus scrofa (Pig) - ATP2A3 gene This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Indicus|evm.model.CM009509.1.320 O43149 ZZEF1_HUMAN 90.702 0.993414 0.974333 ZZEF1 - Zinc finger ZZ-type and EF-hand domain-containing protein 1 - Homo sapiens (Human) - ZZEF1 gene Indicus|evm.model.CM009509.1.321 Q8WUJ1 NEUFC_HUMAN 83.613 0.887218 1.00758 CYB5D2 - Neuferricin precursor - Homo sapiens (Human) - CYB5D2 gene Heme-binding protein which promotes neuronal but not astrocyte differentiation. Indicus|evm.model.CM009509.1.322 Q9P2R3 ANFY1_HUMAN 91.590 0.998336 1.02823 ANKFY1 - Rabankyrin-5 - Homo sapiens (Human) - ANKFY1 gene Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. Indicus|evm.model.CM009509.1.323 P62255 UB2G1_RAT 100.000 0.988304 1.00588 Ube2g1 - Ubiquitin-conjugating enzyme E2 G1 - Rattus norvegicus (Rat) - Ube2g1 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. Indicus|evm.model.CM009509.1.325 Q6ZMD2 SPNS3_HUMAN 84.310 0.850267 1.0957 SPNS3 - Protein spinster homolog 3 - Homo sapiens (Human) - SPNS3 gene Sphingolipid transporter. Indicus|evm.model.CM009509.1.326 Q91VM4 SPNS2_MOUSE 97.863 0.935872 0.908925 Spns2 - Protein spinster homolog 2 - Mus musculus (Mouse) - Spns2 gene Acts a a crucial lysosphingolipid sphingosine 1-phosphate (S1P) transporter involved in S1P secretion and function (PubMed:22664872, PubMed:23180825). S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system. Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:22664872, PubMed:23180825). Indicus|evm.model.CM009509.1.327 Q9BQG0 MBB1A_HUMAN 75.407 0.994092 1.01958 MYBBP1A - Myb-binding protein 1A - Homo sapiens (Human) - MYBBP1A gene May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). Indicus|evm.model.CM009509.1.328 A7YWM1 GGT6_BOVIN 99.592 0.995927 1.00204 GGT6 - Glutathione hydrolase 6 precursor - Bos taurus (Bovine) - GGT6 gene Cleaves glutathione conjugates. Indicus|evm.model.CM009509.1.329 Q32KZ9 TEKT1_BOVIN 100.000 0.995227 1.00239 TEKT1 - Tektin-1 - Bos taurus (Bovine) - TEKT1 gene Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Indicus|evm.model.CM009509.1.330 Q2KI85 SMTL2_BOVIN 100.000 0.995643 1.00218 SMTNL2 - Smoothelin-like protein 2 - Bos taurus (Bovine) - SMTNL2 gene filamentous actin, I band, M band, microtubule organizing center, protein phosphatase 1 binding, tropomyosin binding, actin cytoskeleton organization, positive regulation of vasoconstriction Indicus|evm.model.CM009509.1.331 Q32LM4 FBX39_BOVIN 100.000 0.995495 1.00226 FBXO39 - F-box only protein 39 - Bos taurus (Bovine) - FBXO39 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009509.1.332 Q58DH1 XAF1_BOVIN 98.653 0.993289 1.00337 XAF1 - XIAP-associated factor 1 - Bos taurus (Bovine) - XAF1 gene Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity). Indicus|evm.model.CM009509.1.333 Q86YT5 S13A5_HUMAN 82.363 0.992945 0.998239 SLC13A5 - Solute carrier family 13 member 5 - Homo sapiens (Human) - SLC13A5 gene High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol. Indicus|evm.model.CM009509.1.335 A0JNN3 MED31_BOVIN 100.000 0.984848 1.00763 MED31 - Mediator of RNA polymerase II transcription subunit 31 - Bos taurus (Bovine) - MED31 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009509.1.336 Q9BRA2 TXD17_HUMAN 90.244 0.983871 1.00813 TXNDC17 - Thioredoxin domain-containing protein 17 - Homo sapiens (Human) - TXNDC17 gene Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. Indicus|evm.model.CM009509.1.338 Q2KHM9 MOONR_HUMAN 75.155 0.997875 0.973113 KIAA0753 - Protein moonraker - Homo sapiens (Human) - KIAA0753 gene Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). Indicus|evm.model.CM009509.1.339 Q9BZ71 PITM3_HUMAN 94.271 0.965691 1.01745 PITPNM3 - Membrane-associated phosphatidylinositol transfer protein 3 - Homo sapiens (Human) - PITPNM3 gene Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. Indicus|evm.model.CM009509.1.340 Q9BSJ6 PIMRE_HUMAN 82.895 0.945833 0.967742 PIMREG - Protein PIMREG - Homo sapiens (Human) - PIMREG gene During mitosis, may play a role in the control of metaphase-to-anaphase transition. Indicus|evm.model.CM009509.1.341 Q95MP1 AIPL1_BOVIN 99.695 0.993921 1.00305 AIPL1 - Aryl-hydrocarbon-interacting protein-like 1 - Bos taurus (Bovine) - AIPL1 gene May be important in protein trafficking and/or protein folding and stabilization. Indicus|evm.model.CM009509.1.343 Q658N2 WSCD1_HUMAN 92.870 0.996528 1.00174 WSCD1 - WSC domain-containing protein 1 - Homo sapiens (Human) - WSCD1 gene Indicus|evm.model.CM009509.1.344 Q9C000 NLRP1_HUMAN 58.840 0.984408 0.957909 NLRP1 - NACHT, LRR and PYD domains-containing protein 1 - Homo sapiens (Human) - NLRP1 gene Acts as the sensor component of the NLRP1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis (PubMed:22665479, PubMed:12191486, PubMed:17349957, PubMed:27662089, PubMed:31484767, PubMed:33093214). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:22665479, PubMed:12191486, PubMed:17349957). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, such as cleavage by human rhinoviruses 14 and 16 (HRV-14 and HRV-16), double-stranded RNA or Val-boroPro inhibitor, and mediates the formation of the inflammasome polymeric complex composed of NLRP1, CASP1 and PYCARD/ASC (PubMed:22665479, PubMed:12191486, PubMed:17349957, PubMed:30291141, PubMed:33243852, PubMed:33093214). In response to pathogen-associated signals, the N-terminal part of NLRP1 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1, C-terminus), which polymerizes and associates with PYCARD/ASC to initiate the formation of the inflammasome complex: the NLRP1 inflammasome recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (PubMed:22665479, PubMed:12191486, PubMed:17349957, PubMed:32051255, PubMed:33093214). Activation of NLRP1 inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses (PubMed:22801494). Binds ATP and shows ATPase activity (PubMed:11113115, PubMed:15212762, PubMed:33243852). Plays an important role in antiviral immunity and inflammation in the human airway epithelium (PubMed:33093214). Specifically recognizes a number of pathogen-associated signals: upon infection by human rhinoviruses 14 and 16 (HRV-14 and HRV-16), NLRP1 is cleaved and activated which triggers NLRP1-dependent inflammasome activation and IL18 secretion (PubMed:33093214). Positive-strand RNA viruses such as. Semliki forest virus and long dsRNA activate the NLRP1 inflammasome, triggering IL1B release in a NLRP1-dependent fashion (PubMed:33243852). Acts as a direct sensor for long dsRNA and thus RNA virus infection (PubMed:33243852). May also be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Indicus|evm.model.CM009509.1.346 Q5EA49 MIS12_BOVIN 100.000 0.990338 1.00485 MIS12 - Protein MIS12 homolog - Bos taurus (Bovine) - MIS12 gene Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Essential for proper kinetochore microtubule attachments. Indicus|evm.model.CM009509.1.347 Q5RC74 DERL2_PONAB 100.000 0.922481 1.0795 DERL2 - Derlin-2 - Pongo abelii (Sumatran orangutan) - DERL2 gene Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Indicus|evm.model.CM009509.1.348 Q9H6R0 DHX33_HUMAN 91.513 0.997167 0.998586 DHX33 - ATP-dependent RNA helicase DHX33 - Homo sapiens (Human) - DHX33 gene Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity). Indicus|evm.model.CM009509.1.349 Q3T0B6 C1QBP_BOVIN 100.000 0.992832 1.0036 C1QBP - Complement component 1 Q subcomponent-binding protein, mitochondrial precursor - Bos taurus (Bovine) - C1QBP gene Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense. Indicus|evm.model.CM009509.1.350 Q86UA6 RIP_HUMAN 82.192 0.990909 1.00457 RPAIN - RPA-interacting protein - Homo sapiens (Human) - RPAIN gene Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. Indicus|evm.model.CM009509.1.351 Q99567 NUP88_HUMAN 93.261 0.997308 1.0027 NUP88 - Nuclear pore complex protein Nup88 - Homo sapiens (Human) - NUP88 gene Component of nuclear pore complex. Indicus|evm.model.CM009509.1.352 Q15276 RABE1_HUMAN 97.216 0.997683 1.00116 RABEP1 - Rab GTPase-binding effector protein 1 - Homo sapiens (Human) - RABEP1 gene Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). Indicus|evm.model.CM009509.1.353 Q6UWF3 SCIMP_HUMAN 63.830 0.813953 1.18621 SCIMP - SLP adapter and CSK-interacting membrane protein - Homo sapiens (Human) - SCIMP gene Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity). Indicus|evm.model.CM009509.1.355 Q96NJ6 ZFP3_HUMAN 92.110 0.996063 1.01195 ZFP3 - Zinc finger protein 3 homolog - Homo sapiens (Human) - ZFP3 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009509.1.356 O43896 KIF1C_HUMAN 95.467 0.998187 1 KIF1C - Kinesin-like protein KIF1C - Homo sapiens (Human) - KIF1C gene Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. Indicus|evm.model.CM009509.1.357 Q0VD86 INCA1_HUMAN 74.468 0.939516 1.05085 INCA1 - Protein INCA1 - Homo sapiens (Human) - INCA1 gene Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity). Indicus|evm.model.CM009509.1.358 O94983 CMTA2_HUMAN 94.514 0.943606 1.04742 CAMTA2 - Calmodulin-binding transcription activator 2 - Homo sapiens (Human) - CAMTA2 gene Transcription activator. May act as tumor suppressor. Indicus|evm.model.CM009509.1.359 O75391 SPAG7_HUMAN 98.238 0.991228 1.00441 SPAG7 - Sperm-associated antigen 7 - Homo sapiens (Human) - SPAG7 gene Indicus|evm.model.CM009509.1.360 Q3ZC09 ENOB_BOVIN 100.000 0.981859 1.01613 ENO3 - Beta-enolase - Bos taurus (Bovine) - ENO3 gene Appears to have a function in striated muscle development and regeneration. Indicus|evm.model.CM009509.1.361 P02584 PROF1_BOVIN 100.000 0.985816 1.00714 PFN1 - Profilin-1 - Bos taurus (Bovine) - PFN1 gene Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). Indicus|evm.model.CM009509.1.362 Q9H6Y7 RN167_HUMAN 95.683 0.926421 0.854286 RNF167 - E3 ubiquitin-protein ligase RNF167 precursor - Homo sapiens (Human) - RNF167 gene May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition. Indicus|evm.model.CM009509.1.363 P22292 M2OM_BOVIN 100.000 0.993651 1.00318 SLC25A11 - Mitochondrial 2-oxoglutarate/malate carrier protein - Bos taurus (Bovine) - SLC25A11 gene Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis. Indicus|evm.model.CM009509.1.364 Q9JM99 PRG4_MOUSE 72.381 0.159754 0.617647 Prg4 - Proteoglycan 4 precursor - Mus musculus (Mouse) - Prg4 gene Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Indicus|evm.model.CM009509.1.365 P02715 ACHE_BOVIN 97.206 0.996016 1.0224 CHRNE - Acetylcholine receptor subunit epsilon precursor - Bos taurus (Bovine) - CHRNE gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Indicus|evm.model.CM009509.1.366 Q8N4C8 MINK1_HUMAN 97.017 0.998507 1.00601 MINK1 - Misshapen-like kinase 1 - Homo sapiens (Human) - MINK1 gene Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Indicus|evm.model.CM009509.1.367 Q0V8L6 PLD2_BOVIN 99.890 0.954593 1.01501 PLD2 - Phospholipase D2 - Bos taurus (Bovine) - PLD2 gene Function as phospholipase selective for phosphatidylcholine. May have a role in signal-induced cytoskeletal regulation and/or endocytosis. Indicus|evm.model.CM009509.1.368 Q3MHN0 PSB6_BOVIN 100.000 0.991667 1.00418 PSMB6 - Proteasome subunit beta type-6 precursor - Bos taurus (Bovine) - PSMB6 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues. Indicus|evm.model.CM009509.1.369 A6NH11 GLTD2_HUMAN 67.354 0.992857 0.962199 GLTPD2 - Glycolipid transfer protein domain-containing protein 2 - Homo sapiens (Human) - GLTPD2 gene cytosol, membrane, ceramide 1-phosphate binding, ceramide 1-phosphate transfer activity, ceramide transport, intermembrane lipid transfer Indicus|evm.model.CM009509.1.370 Q7Z5L0 VMO1_HUMAN 77.723 0.99 0.990099 VMO1 - Vitelline membrane outer layer protein 1 homolog precursor - Homo sapiens (Human) - VMO1 gene extracellular exosome, extracellular space Indicus|evm.model.CM009509.1.371 Q2KIG8 T4S5_BOVIN 99.490 0.989848 1.0051 TM4SF5 - Transmembrane 4 L6 family member 5 - Bos taurus (Bovine) - TM4SF5 gene Acts as a lysosomal membrane arginine sensor (By similarity). Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations (By similarity). Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus (By similarity). CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression (By similarity). Indicus|evm.model.CM009509.1.372 Q9H091 ZMY15_HUMAN 88.005 0.997301 0.998652 ZMYND15 - Zinc finger MYND domain-containing protein 15 - Homo sapiens (Human) - ZMYND15 gene Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis. Indicus|evm.model.CM009509.1.373 Q29RT9 CXL16_BOVIN 98.413 0.992095 1.00397 CXCL16 - C-X-C motif chemokine 16 precursor - Bos taurus (Bovine) - CXCL16 gene Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Indicus|evm.model.CM009509.1.374 Q9P086 MED11_HUMAN 99.145 0.983051 1.00855 MED11 - Mediator of RNA polymerase II transcription subunit 11 - Homo sapiens (Human) - MED11 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Indicus|evm.model.CM009509.1.375 P32120 ARRB2_BOVIN 97.381 0.995122 0.97619 ARRB2 - Beta-arrestin-2 - Bos taurus (Bovine) - ARRB2 gene Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Acts as an adapter protein coupling FFAR4 receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis. During the activation step of NLRP3 inflammasome, directly associates with NLRP3 leading to inhibition of proinflammatory cytokine release and inhibition of inflammation. Indicus|evm.model.CM009509.1.376 Q8IZL8 PELP1_HUMAN 88.388 0.785139 0.988496 PELP1 - Proline-, glutamic acid- and leucine-rich protein 1 - Homo sapiens (Human) - PELP1 gene Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Indicus|evm.model.CM009509.1.377 P27479 LOX15_BOVIN 100.000 0.996988 1.00151 ALOX15 - Polyunsaturated fatty acid lipoxygenase ALOX15 - Bos taurus (Bovine) - ALOX15 gene Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:1539676). It may then act on 12-HPETE to produce hepoxilins, which may show proinflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively downregulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (By similarity). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (By similarity). Indicus|evm.model.CM009509.1.378 D3ZQF9 LX12E_RAT 82.175 0.996983 1.00151 Alox12e - Polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type - Rattus norvegicus (Rat) - Alox12e gene Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:23382512). Shows increasing catalytic activity within the series arachidonic acid Indicus|evm.model.CM009509.1.379 Q3ZBN4 CUED2_BOVIN 98.936 0.570552 0.575972 CUEDC2 - CUE domain-containing protein 2 - Bos taurus (Bovine) - CUEDC2 gene Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Indicus|evm.model.CM009509.1.380 Q3ZBN4 CUED2_BOVIN 96.855 0.981366 0.568905 CUEDC2 - CUE domain-containing protein 2 - Bos taurus (Bovine) - CUEDC2 gene Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Indicus|evm.model.CM009509.1.381 P18054 LOX12_HUMAN 87.330 0.996988 1.00151 ALOX12 - Polyunsaturated fatty acid lipoxygenase ALOX12 - Homo sapiens (Human) - ALOX12 gene Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:17493578, PubMed:1851637, PubMed:8319693, PubMed:8500694, PubMed:18311922, PubMed:32404334). Mainly converts arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to the specific bioactive lipid (12S)-hydroperoxyeicosatetraenoate/(12S)-HPETE (PubMed:17493578, PubMed:22984144, PubMed:24282679, PubMed:8319693, PubMed:8500694). Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:8319693, PubMed:8500694). It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA (PubMed:23504711). Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively downregulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). An additional function involves a multistep process by which it transforms leukotriene A4/LTA4 into the bioactive lipids lipoxin A4/LXA4 and lipoxin B4/LXB4, both are vasoactive and LXA4 may regulate neutrophil function via occupancy of specific recognition sites (PubMed:8250832). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to (13S)-hydroperoxyoctadecadienoate/ (13S-HPODE) (By similarity). Due to its role in regulating both the expression of the vascular endothelial growth factor (VEGF, an angiogenic factor involved in the survival and metastasis of solid tumors) and the expression of integrin beta-1 (known to affect tumor cell migration and proliferation), it can be regarded as protumorigenic (PubMed:9751607, PubMed:16638750, PubMed:22237009). Important for cell survival, as it may play a role not only in proliferation but also in the prevention of apoptosis in vascular smooth muscle cells (PubMed:23578768). Indicus|evm.model.CM009509.1.382 Q3ZC23 RNK_BOVIN 100.000 0.633987 1.56122 RNASEK - Ribonuclease kappa - Bos taurus (Bovine) - RNASEK gene Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate (By similarity). Indicus|evm.model.CM009509.1.383 Q32LD1 BAP18_BOVIN 100.000 0.988439 1.00581 BAP18 - Chromatin complexes subunit BAP18 - Bos taurus (Bovine) - BAP18 gene Component of chromatin complexes such as the MLL1/MLL and NURF complexes. Indicus|evm.model.CM009509.1.384 Q8N143 BCL6B_HUMAN 91.858 0.995781 0.989562 BCL6B - B-cell CLL/lymphoma 6 member B protein - Homo sapiens (Human) - BCL6B gene Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development. Indicus|evm.model.CM009509.1.385 Q17QR6 MOT13_BOVIN 99.765 0.995316 1.00235 SLC16A13 - Monocarboxylate transporter 13 - Bos taurus (Bovine) - SLC16A13 gene Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Indicus|evm.model.CM009509.1.386 Q8NCK7 MOT11_HUMAN 72.345 0.995283 0.900212 SLC16A11 - Monocarboxylate transporter 11 - Homo sapiens (Human) - SLC16A11 gene Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345). Indicus|evm.model.CM009509.1.387 Q8IUN9 CLC10_HUMAN 58.065 0.987055 0.977848 CLEC10A - C-type lectin domain family 10 member A - Homo sapiens (Human) - CLEC10A gene Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. Indicus|evm.model.CM009509.1.388 P07307 ASGR2_HUMAN 70.455 0.990066 0.971061 ASGR2 - Asialoglycoprotein receptor 2 - Homo sapiens (Human) - ASGR2 gene Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Indicus|evm.model.CM009509.1.389 P07306 ASGR1_HUMAN 80.851 0.97561 0.986254 ASGR1 - Asialoglycoprotein receptor 1 - Homo sapiens (Human) - ASGR1 gene Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Indicus|evm.model.CM009509.1.390 P78352 DLG4_HUMAN 94.980 0.997351 1.04282 DLG4 - Disks large homolog 4 - Homo sapiens (Human) - DLG4 gene Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. Indicus|evm.model.CM009509.1.391 P48818 ACADV_BOVIN 100.000 0.996951 1.00153 ACADVL - Very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACADVL gene Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains. Indicus|evm.model.CM009509.1.392 O14641 DVL2_HUMAN 97.690 0.997286 1.00136 DVL2 - Segment polarity protein dishevelled homolog DVL-2 - Homo sapiens (Human) - DVL2 gene Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Indicus|evm.model.CM009509.1.393 A5D962 PHF23_BOVIN 96.269 0.994962 0.9925 PHF23 - PHD finger protein 23 - Bos taurus (Bovine) - PHF23 gene Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. Indicus|evm.model.CM009509.1.394 P60517 GBRAP_RAT 100.000 0.983051 1.00855 Gabarap - Gamma-aminobutyric acid receptor-associated protein precursor - Rattus norvegicus (Rat) - Gabarap gene Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:11461150). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (By similarity). Also required for the local activition of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination a nd degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (By similarity). Involved in apoptosis (By similarity). Indicus|evm.model.CM009509.1.395 Q1RMV9 CNEP1_BOVIN 100.000 0.991837 1.0041 CTDNEP1 - CTD nuclear envelope phosphatase 1 - Bos taurus (Bovine) - CTDNEP1 gene Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity). Indicus|evm.model.CM009509.1.396 Q8TE02 ELP5_HUMAN 83.566 0.946844 0.952532 ELP5 - Elongator complex protein 5 - Homo sapiens (Human) - ELP5 gene Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:22854966). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation (PubMed:16850183). Indicus|evm.model.CM009509.1.397 Q3B7N4 CLD7_BOVIN 100.000 0.990566 1.00474 CLDN7 - Claudin-7 - Bos taurus (Bovine) - CLDN7 gene Plays a major role in tight junction-specific obliteration of the intercellular space. Indicus|evm.model.CM009509.1.398 Q27994 GLUT4_BOVIN 100.000 0.996078 1.00196 SLC2A4 - Solute carrier family 2, facilitated glucose transporter member 4 - Bos taurus (Bovine) - SLC2A4 gene Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. Indicus|evm.model.CM009509.1.399 Q9Z2C8 YBOX2_MOUSE 97.000 0.828255 1.00278 Ybx2 - Y-box-binding protein 2 - Mus musculus (Mouse) - Ybx2 gene Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay. Indicus|evm.model.CM009509.1.400 Q3T1J1 IF5A1_RAT 100.000 0.987097 1.00649 Eif5a - Eukaryotic translation initiation factor 5A-1 - Rattus norvegicus (Rat) - Eif5a gene mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Indicus|evm.model.CM009509.1.401 Q13227 GPS2_HUMAN 98.777 0.17086 5.83486 GPS2 - G protein pathway suppressor 2 - Homo sapiens (Human) - GPS2 gene Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:19858209, PubMed:24943844). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (PubMed:20159957). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (By similarity). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the proinflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity (By similarity). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (By similarity). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). Acts as a tumor-suppressor in liposarcoma (PubMed:27460081). Indicus|evm.model.CM009509.1.402 Q3SZX2 IPP2_BOVIN 45.638 0.247601 2.51691 PPP1R2 - Protein phosphatase inhibitor 2 - Bos taurus (Bovine) - PPP1R2 gene Inhibitor of protein-phosphatase 1. Indicus|evm.model.CM009509.1.403 A5PK26 ACAP1_BOVIN 97.616 0.99734 1.0094 ACAP1 - Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 - Bos taurus (Bovine) - ACAP1 gene GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity). Indicus|evm.model.CM009509.1.404 Q58DF7 KCD11_BOVIN 99.569 0.991416 1.00431 KCTD11 - BTB/POZ domain-containing protein KCTD11 - Bos taurus (Bovine) - KCTD11 gene Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive (By similarity). Indicus|evm.model.CM009509.1.405 A0A3Q1LRJ2 TMM95_BOVIN 100.000 0.942857 1.05422 TMEM95 - Sperm-egg fusion protein TMEM95 precursor - Bos taurus (Bovine) - TMEM95 gene Sperm protein required for fusion of sperm with the egg membrane during fertilization. Indicus|evm.model.CM009509.1.406 Q13470 TNK1_HUMAN 82.459 0.996956 0.986486 TNK1 - Non-receptor tyrosine-protein kinase TNK1 - Homo sapiens (Human) - TNK1 gene Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. Indicus|evm.model.CM009509.1.407 Q9NRY6 PLS3_HUMAN 92.409 0.993421 1.03051 PLSCR3 - Phospholipid scramblase 3 - Homo sapiens (Human) - PLSCR3 gene Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:29337693, PubMed:31769662). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:12649167). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (PubMed:14573790, PubMed:17226776, PubMed:18358005). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (PubMed:18491232). Regulates cardiolipin de novo biosynthesis and its resynthesis (PubMed:16939411). Indicus|evm.model.CM009509.1.408 Q2KI29 TM256_BOVIN 100.000 0.982456 1.00885 TMEM256 - Transmembrane protein 256 precursor - Bos taurus (Bovine) - TMEM256 gene Indicus|evm.model.CM009509.1.409 Q8NFZ4 NLGN2_HUMAN 99.766 0.951002 0.537725 NLGN2 - Neuroligin-2 precursor - Homo sapiens (Human) - NLGN2 gene Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). Indicus|evm.model.CM009509.1.410 Q0P670 SPEM2_HUMAN 65.310 0.918 0.998004 SPEM2 - Uncharacterized protein SPEM2 - Homo sapiens (Human) - SPEM2 gene Indicus|evm.model.CM009509.1.411 Q1LZD1 TM102_BOVIN 100.000 0.287376 3.35742 TMEM102 - Transmembrane protein 102 - Bos taurus (Bovine) - TMEM102 gene Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. Indicus|evm.model.CM009509.1.412 P70378 FGF11_MOUSE 99.107 0.986726 1.00444 Fgf11 - Fibroblast growth factor 11 - Mus musculus (Mouse) - Fgf11 gene Probably involved in nervous system development and function. Indicus|evm.model.CM009509.1.413 P04758 ACHB_BOVIN 100.000 0.996047 1.00198 CHRNB1 - Acetylcholine receptor subunit beta precursor - Bos taurus (Bovine) - CHRNB1 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Indicus|evm.model.CM009509.1.414 Q9P1Z0 ZBTB4_HUMAN 88.889 0.99802 0.997038 ZBTB4 - Zinc finger and BTB domain-containing protein 4 - Homo sapiens (Human) - ZBTB4 gene Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). Indicus|evm.model.CM009509.1.415 Q5F297 S35G3_MOUSE 89.706 0.951977 1.04118 Slc35g3 - Solute carrier family 35 member G3 - Mus musculus (Mouse) - Slc35g3 gene integral component of membrane Indicus|evm.model.CM009509.1.416 P08775 RPB1_MOUSE 94.521 0.984111 0.990355 Polr2a - DNA-directed RNA polymerase II subunit RPB1 - Mus musculus (Mouse) - Polr2a gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates (By similarity). Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity). Regulation of gene expression levels depends on the balance between methylation and acetylation levels of tha CTD-lysines (PubMed:26687004). Initiation or early elongation steps of transcription of growth-factors-induced immediate early genes are regulated by the acetylation status of the CTD (PubMed:24207025). Methylation and dimethylation have a repressive effect on target genes expression (PubMed:26687004). Indicus|evm.model.CM009509.1.417 O43508 TNF12_HUMAN 84.255 0.624665 1.49799 TNFSF12 - Tumor necrosis factor ligand superfamily member 12 - Homo sapiens (Human) - TNFSF12 gene Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. Indicus|evm.model.CM009509.1.418 Q9H4L4 SENP3_HUMAN 96.167 0.738402 1.35192 SENP3 - Sentrin-specific protease 3 - Homo sapiens (Human) - SENP3 gene Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Indicus|evm.model.CM009509.1.419 P60843 IF4A1_MOUSE 100.000 0.995086 1.00246 Eif4a1 - Eukaryotic initiation factor 4A-I - Mus musculus (Mouse) - Eif4a1 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Indicus|evm.model.CM009509.1.420 P34810 CD68_HUMAN 72.067 0.994048 0.949153 CD68 - Macrosialin precursor - Homo sapiens (Human) - CD68 gene Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Indicus|evm.model.CM009509.1.421 O75352 MPU1_HUMAN 93.469 0.987854 1 MPDU1 - Mannose-P-dolichol utilization defect 1 protein - Homo sapiens (Human) - MPDU1 gene Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. Indicus|evm.model.CM009509.1.422 O60248 SOX15_HUMAN 81.116 0.991453 1.00429 SOX15 - Protein SOX-15 - Homo sapiens (Human) - SOX15 gene Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity). Regulates transcription of HRC via binding to it proximal enhancer region (By similarity). Involved in skeletal muscle regeneration (By similarity). Also plays a role in the development of myogenic precursor cells (By similarity). Indicus|evm.model.CM009509.1.423 P51116 FXR2_HUMAN 98.410 0.785982 1.18722 FXR2 - Fragile X mental retardation syndrome-related protein 2 - Homo sapiens (Human) - FXR2 gene RNA-binding protein. Indicus|evm.model.CM009509.1.424 P04278 SHBG_HUMAN 74.876 0.938967 1.0597 SHBG - Sex hormone-binding globulin precursor - Homo sapiens (Human) - SHBG gene Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. Indicus|evm.model.CM009509.1.425 Q5J583 AT1B2_OCHCU 99.310 0.993127 1.00345 ATP1B2 - Sodium/potassium-transporting ATPase subunit beta-2 - Ochotona curzoniae (Black-lipped pika) - ATP1B2 gene This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (By similarity). Indicus|evm.model.CM009509.1.426 P67939 P53_BOVIN 100.000 0.994832 1.00259 TP53 - Cellular tumor antigen p53 - Bos taurus (Bovine) - TP53 gene Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2. Indicus|evm.model.CM009509.1.427 Q3SWZ7 TCAB1_BOVIN 100.000 0.996303 1.00185 WRAP53 - Telomerase Cajal body protein 1 - Bos taurus (Bovine) - WRAP53 gene RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity. In addition, also controls telomerase holoenzyme complex localization to Cajal body. During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity. In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies. Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks. Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ). Indicus|evm.model.CM009509.1.428 Q15768 EFNB3_HUMAN 97.059 0.994135 1.00294 EFNB3 - Ephrin-B3 precursor - Homo sapiens (Human) - EFNB3 gene Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). Indicus|evm.model.CM009509.1.429 Q9P225 DYH2_HUMAN 93.314 0.895718 1.01807 DNAH2 - Dynein axonemal heavy chain 2 - Homo sapiens (Human) - DNAH2 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Indicus|evm.model.CM009509.1.430 Q5NCY0 KDM6B_MOUSE 93.564 0.493268 0.995734 Kdm6b - Lysine-specific demethylase 6B - Mus musculus (Mouse) - Kdm6b gene Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (PubMed:21095589). Indicus|evm.model.CM009509.1.431 A5D7M7 TMM88_BOVIN 100.000 0.9875 1.00629 TMEM88 - Transmembrane protein 88 - Bos taurus (Bovine) - TMEM88 gene Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity). Indicus|evm.model.CM009509.1.432 Q9BRA0 LSMD1_HUMAN 96.825 0.984252 1.016 NAA38 - N-alpha-acetyltransferase 38, NatC auxiliary subunit - Homo sapiens (Human) - NAA38 gene Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Indicus|evm.model.CM009509.1.434 Q12873 CHD3_HUMAN 97.693 0.990065 1.0065 CHD3 - Chromodomain-helicase-DNA-binding protein 3 - Homo sapiens (Human) - CHD3 gene Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones (PubMed:9804427, PubMed:30397230). Involved in transcriptional repressiobn as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). Indicus|evm.model.CM009509.1.435 Q9DCB3 RN227_MOUSE 50.265 0.983696 0.968421 Rnf227 - RING finger protein 227 - Mus musculus (Mouse) - Rnf227 gene Indicus|evm.model.CM009509.1.436 O43448 KCAB3_HUMAN 96.782 0.995062 1.00248 KCNAB3 - Voltage-gated potassium channel subunit beta-3 - Homo sapiens (Human) - KCNAB3 gene Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5. Indicus|evm.model.CM009509.1.437 Q9Y5R8 TPPC1_HUMAN 100.000 0.986301 1.0069 TRAPPC1 - Trafficking protein particle complex subunit 1 - Homo sapiens (Human) - TRAPPC1 gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Indicus|evm.model.CM009509.1.438 Q8N137 CNTRB_HUMAN 88.442 0.90411 0.242525 CNTROB - Centrobin - Homo sapiens (Human) - CNTROB gene Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. Indicus|evm.model.CM009509.1.439 Q8N137 CNTRB_HUMAN 87.500 0.971545 0.272425 CNTROB - Centrobin - Homo sapiens (Human) - CNTROB gene Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. Indicus|evm.model.CM009509.1.440 Q8N137 CNTRB_HUMAN 83.514 0.995671 0.511628 CNTROB - Centrobin - Homo sapiens (Human) - CNTROB gene Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. Indicus|evm.model.CM009509.1.441 P55203 GUC2D_BOVIN 99.820 0.9982 1.0009 GUCY2D - Retinal guanylyl cyclase 1 precursor - Bos taurus (Bovine) - GUCY2D gene Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:8102054). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). Indicus|evm.model.CM009509.1.442 O15296 LX15B_HUMAN 82.493 0.634906 1.56805 ALOX15B - Polyunsaturated fatty acid lipoxygenase ALOX15B - Homo sapiens (Human) - ALOX15B gene Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (PubMed:9177185, PubMed:10625675, PubMed:12704195, PubMed:17493578, PubMed:18311922, PubMed:24282679, PubMed:10542053, PubMed:24497644, PubMed:32404334) (Probable). It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (PubMed:17493578, PubMed:12704195, PubMed:24282679, PubMed:9177185, PubMed:11956198, PubMed:10625675, PubMed:24497644) (Probable). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (Probable) (PubMed:10542053, PubMed:27435673). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist (PubMed:18311922, PubMed:17493578, PubMed:11956198). Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates (PubMed:27145229). Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively downregulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids (PubMed:27435673). Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation (PubMed:12704195, PubMed:11839751). May also regulate cytokine secretion by macrophages and therefore play a role in the immune response (PubMed:18067895). May also regulate macrophage differentiation into proatherogenic foam cells (PubMed:22912809). Indicus|evm.model.CM009509.1.443 O75342 LX12B_HUMAN 88.160 0.997143 0.998573 ALOX12B - Arachidonate 12-lipoxygenase, 12R-type - Homo sapiens (Human) - ALOX12B gene Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:9837935, PubMed:9618483, PubMed:21558561). In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PubMed:21558561). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:21558561). May also play a role in the regulation of the expression of airway mucins (PubMed:22441738). Indicus|evm.model.CM009509.1.444 Q9BYJ1 LOXE3_HUMAN 89.170 0.771739 1.29395 ALOXE3 - Hydroperoxide isomerase ALOXE3 - Homo sapiens (Human) - ALOXE3 gene Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity (PubMed:12881489, PubMed:17045234, PubMed:20921226, PubMed:20923767). The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones (PubMed:12881489, PubMed:17045234, PubMed:20923767). In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides (PubMed:20921226). In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PubMed:21558561). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:21558561). In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (PubMed:21558561). Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity). Indicus|evm.model.CM009509.1.445 O15534 PER1_HUMAN 90.310 0.996109 0.996124 PER1 - Period circadian protein homolog 1 - Homo sapiens (Human) - PER1 gene Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Indicus|evm.model.CM009509.1.446 P63026 VAMP2_BOVIN 98.684 0.619835 1.0431 VAMP2 - Vesicle-associated membrane protein 2 - Bos taurus (Bovine) - VAMP2 gene Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity). Indicus|evm.model.CM009509.1.447 Q642C0 DNJC8_RAT 94.619 0.917355 0.956522 Dnajc8 - DnaJ homolog subfamily C member 8 - Rattus norvegicus (Rat) - Dnajc8 gene Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells. Indicus|evm.model.CM009509.1.448 Q6UX40 TM107_HUMAN 92.143 0.985816 1.00714 TMEM107 - Transmembrane protein 107 - Homo sapiens (Human) - TMEM107 gene Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474). Indicus|evm.model.CM009509.1.449 Q3SX20 BORC6_BOVIN 99.150 0.99435 1.00283 BORCS6 - BLOC-1-related complex subunit 6 - Bos taurus (Bovine) - BORCS6 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Indicus|evm.model.CM009509.1.450 Q7YRC6 AURKB_BOVIN 99.709 0.994203 1.00291 AURKB - Aurora kinase B - Bos taurus (Bovine) - AURKB gene Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Indicus|evm.model.CM009509.1.451 Q2NKJ3 CTC1_HUMAN 76.639 0.998348 0.99507 CTC1 - CST complex subunit CTC1 - Homo sapiens (Human) - CTC1 gene Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Involved in telomere maintenance (PubMed:19854131, PubMed:22863775). Involved in genome stability (PubMed:22863775). May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity). Indicus|evm.model.CM009509.1.452 O15067 PUR4_HUMAN 89.013 0.977339 1.02242 PFAS - Phosphoribosylformylglycinamidine synthase - Homo sapiens (Human) - PFAS gene Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity). Indicus|evm.model.CM009509.1.453 Q32PE2 MOG1_BOVIN 98.387 0.989305 1.00538 RANGRF - Ran guanine nucleotide release factor - Bos taurus (Bovine) - RANGRF gene May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes. Indicus|evm.model.CM009509.1.454 Q3KQZ1 S2535_HUMAN 92.667 0.993355 1.00333 SLC25A35 - Solute carrier family 25 member 35 - Homo sapiens (Human) - SLC25A35 gene Indicus|evm.model.CM009509.1.455 O94989 ARHGF_HUMAN 89.231 0.993046 0.854935 ARHGEF15 - Rho guanine nucleotide exchange factor 15 - Homo sapiens (Human) - ARHGEF15 gene Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. Indicus|evm.model.CM009509.1.456 Q0II41 ODFP4_BOVIN 98.477 0.566474 1.73869 ODF4 - Outer dense fiber protein 4 - Bos taurus (Bovine) - ODF4 gene Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton. Indicus|evm.model.CM009509.1.457 Q6ZNG9 KRBA2_HUMAN 86.792 0.898089 0.957317 KRBA2 - KRAB-A domain-containing protein 2 - Homo sapiens (Human) - KRBA2 gene Indicus|evm.model.CM009509.1.458 P61255 RL26_MOUSE 100.000 0.386059 2.57241 Rpl26 - 60S ribosomal protein L26 - Mus musculus (Mouse) - Rpl26 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009509.1.459 O46480 NDEL1_RABIT 99.130 0.99422 1.0029 NDEL1 - Nuclear distribution protein nudE-like 1 - Oryctolagus cuniculus (Rabbit) - NDEL1 gene Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Indicus|evm.model.CM009509.1.460 Q27991 MYH10_BOVIN 100.000 0.987994 1.01164 MYH10 - Myosin-10 - Bos taurus (Bovine) - MYH10 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Indicus|evm.model.CM009509.1.461 A6QQM8 CCD42_BOVIN 100.000 0.993691 1.00316 CCDC42 - Coiled-coil domain-containing protein 42 - Bos taurus (Bovine) - CCDC42 gene Required for sperm development. Indicus|evm.model.CM009509.1.462 Q8IWD5 MFS6L_HUMAN 70.370 0.991639 1.02048 MFSD6L - Major facilitator superfamily domain-containing protein 6-like - Homo sapiens (Human) - MFSD6L gene membrane Indicus|evm.model.CM009509.1.463 Q5UE93 PI3R6_HUMAN 82.446 0.871698 1.05438 PIK3R6 - Phosphoinositide 3-kinase regulatory subunit 6 - Homo sapiens (Human) - PIK3R6 gene Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. Indicus|evm.model.CM009509.1.464 O02696 PI3R5_PIG 89.201 0.997743 1.01026 PIK3R5 - Phosphoinositide 3-kinase regulatory subunit 5 - Sus scrofa (Pig) - PIK3R5 gene Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG. Indicus|evm.model.CM009509.1.465 O95631 NET1_HUMAN 99.666 0.973941 1.01656 NTN1 - Netrin-1 precursor - Homo sapiens (Human) - NTN1 gene Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335). Indicus|evm.model.CM009509.1.466 Q3T075 STX8_BOVIN 100.000 0.991561 1.00424 STX8 - Syntaxin-8 - Bos taurus (Bovine) - STX8 gene Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. Indicus|evm.model.CM009509.1.467 Q8N1V2 CFA52_HUMAN 90.805 0.987013 0.993548 CFAP52 - Cilia- and flagella-associated protein 52 - Homo sapiens (Human) - CFAP52 gene May play a role in cell growth and/or survival. Indicus|evm.model.CM009509.1.468 Q70EL4 UBP43_HUMAN 79.372 0.969271 1.01425 USP43 - Ubiquitin carboxyl-terminal hydrolase 43 - Homo sapiens (Human) - USP43 gene May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Indicus|evm.model.CM009509.1.469 Q1RMJ5 DRS7C_BOVIN 99.359 0.99361 1.00643 DHRS7C - Dehydrogenase/reductase SDR family member 7C precursor - Bos taurus (Bovine) - DHRS7C gene Putative oxidoreductase. Indicus|evm.model.CM009509.1.470 A8MUP6 GS1L2_HUMAN 72.789 0.99308 0.986348 GSG1L2 - Germ cell-specific gene 1-like protein 2 - Homo sapiens (Human) - GSG1L2 gene plasma membrane Indicus|evm.model.CM009509.1.471 O95838 GLP2R_HUMAN 78.958 0.766154 1.17541 GLP2R - Glucagon-like peptide 2 receptor - Homo sapiens (Human) - GLP2R gene This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Indicus|evm.model.CM009509.1.472 P21457 RECO_BOVIN 99.502 0.985222 1.00495 RCVRN - Recoverin - Bos taurus (Bovine) - RCVRN gene Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (PubMed:1672047, PubMed:1672637). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (PubMed:1672047, PubMed:1672637, PubMed:8392055, PubMed:16675451, PubMed:21299498, PubMed:12686556, PubMed:17015448). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity). Indicus|evm.model.CM009509.1.473 O60861 GAS7_HUMAN 97.143 0.809302 0.451681 GAS7 - Growth arrest-specific protein 7 - Homo sapiens (Human) - GAS7 gene May play a role in promoting maturation and morphological differentiation of cerebellar neurons. Indicus|evm.model.CM009509.1.474 Q076A3 MYH13_CANLF 94.611 0.951135 1.04433 MYH13 - Myosin-13 - Canis lupus familiaris (Dog) - MYH13 gene Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. Indicus|evm.model.CM009509.1.475 Q076A4 MYH8_CANLF 97.370 0.998968 0.999484 MYH8 - Myosin-8 - Canis lupus familiaris (Dog) - MYH8 gene Muscle contraction. Indicus|evm.model.CM009509.1.476 Q9TV62 MYH4_PIG 97.007 0.998969 1.00103 MYH4 - Myosin-4 - Sus scrofa (Pig) - MYH4 gene Muscle contraction. Indicus|evm.model.CM009509.1.477 Q9BE40 MYH1_BOVIN 100.000 0.998969 1.00052 MYH1 - Myosin-1 - Bos taurus (Bovine) - MYH1 gene Muscle contraction. Indicus|evm.model.CM009509.1.478 Q9BE41 MYH2_BOVIN 99.948 0.976826 1.0232 MYH2 - Myosin-2 - Bos taurus (Bovine) - MYH2 gene Muscle contraction. Required for cytoskeleton organization (By similarity). Indicus|evm.model.CM009509.1.479 P11055 MYH3_HUMAN 95.582 0.979592 1.03557 MYH3 - Myosin-3 - Homo sapiens (Human) - MYH3 gene Muscle contraction. Indicus|evm.model.CM009509.1.480 A1A4J8 SCO1_BOVIN 100.000 0.62423 1.59672 SCO1 - Protein SCO1 homolog, mitochondrial precursor - Bos taurus (Bovine) - SCO1 gene Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1. Indicus|evm.model.CM009509.1.481 A7YY53 ADPRM_BOVIN 99.703 0.994083 1.00297 ADPRM - Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase - Bos taurus (Bovine) - ADPRM gene Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity). Indicus|evm.model.CM009509.1.482 Q8BP07 TM220_MOUSE 75.449 0.988095 1.00599 Tmem220 - Transmembrane protein 220 - Mus musculus (Mouse) - Tmem220 gene Indicus|evm.model.CM009509.1.483 A6NJY4 T238L_HUMAN 72.152 0.678261 1.4557 TMEM238L - Transmembrane protein 238-like - Homo sapiens (Human) - TMEM238L gene Indicus|evm.model.CM009509.1.484 P0C851 PIRT_HUMAN 85.185 0.985294 0.992701 PIRT - Phosphoinositide-interacting protein - Homo sapiens (Human) - PIRT gene Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity). Indicus|evm.model.CM009509.1.485 Q6ZSJ9 SHSA6_HUMAN 98.295 0.680934 0.514 SHISA6 - Protein shisa-6 precursor - Homo sapiens (Human) - SHISA6 gene Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway. Indicus|evm.model.CM009509.1.486 Q3UH99 SHSA6_MOUSE 94.894 0.89313 0.499048 Shisa6 - Protein shisa-6 precursor - Mus musculus (Mouse) - Shisa6 gene Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed:26931375). May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway (PubMed:28196692). Indicus|evm.model.CM009509.1.487 Q9NYC9 DYH9_HUMAN 85.401 0.996609 0.985956 DNAH9 - Dynein axonemal heavy chain 9 - Homo sapiens (Human) - DNAH9 gene Force generating protein required for cilia beating in respiratory epithelia (PubMed:30471717, PubMed:30471718). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Indicus|evm.model.CM009509.1.488 P17022 ZNF18_HUMAN 74.701 0.991984 0.908925 ZNF18 - Zinc finger protein 18 - Homo sapiens (Human) - ZNF18 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009509.1.490 P45985 MP2K4_HUMAN 99.448 0.916244 0.987469 MAP2K4 - Dual specificity mitogen-activated protein kinase kinase 4 - Homo sapiens (Human) - MAP2K4 gene Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. Indicus|evm.model.CM009509.1.492 Q7YR76 MYCD_PIG 83.247 0.997925 1.03323 MYOCD - Myocardin - Sus scrofa (Pig) - MYOCD gene Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Indicus|evm.model.CM009509.1.493 Q17R89 RHG44_HUMAN 91.697 0.997525 0.987775 ARHGAP44 - Rho GTPase-activating protein 44 - Homo sapiens (Human) - ARHGAP44 gene GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). Indicus|evm.model.CM009509.1.494 Q8HY87 RNZ2_MACFA 82.228 0.424 1.05932 ELAC2 - Zinc phosphodiesterase ELAC protein 2 precursor - Macaca fascicularis (Crab-eating macaque) - ELAC2 gene Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. Indicus|evm.model.CM009509.1.495 Q8BKN6 HS3SA_MOUSE 89.143 0.988636 0.447837 Hs3st3a1 - Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 - Mus musculus (Mouse) - Hs3st3a1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Indicus|evm.model.CM009509.1.496 Q9QZS6 HS3SB_MOUSE 98.113 0.361111 0.369231 Hs3st3b1 - Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 - Mus musculus (Mouse) - Hs3st3b1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Indicus|evm.model.CM009509.1.499 Q12887 COX10_HUMAN 85.553 0.995495 1.00226 COX10 - Protoheme IX farnesyltransferase, mitochondrial precursor - Homo sapiens (Human) - COX10 gene Converts protoheme IX and farnesyl diphosphate to heme O. Indicus|evm.model.CM009509.1.500 Q9Y663 HS3SA_HUMAN 98.148 0.288043 0.453202 HS3ST3A1 - Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 - Homo sapiens (Human) - HS3ST3A1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Indicus|evm.model.CM009509.1.501 Q9QZS6 HS3SB_MOUSE 90.148 0.990196 0.523077 Hs3st3b1 - Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 - Mus musculus (Mouse) - Hs3st3b1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Indicus|evm.model.CM009509.1.502 Q9TQZ3 PMP22_BOVIN 100.000 0.987578 1.00625 PMP22 - Peripheral myelin protein 22 - Bos taurus (Bovine) - PMP22 gene Might be involved in growth regulation, and in myelinization in the peripheral nervous system. Indicus|evm.model.CM009509.1.503 A6H782 TEKT3_BOVIN 99.592 0.995927 1.00204 TEKT3 - Tektin-3 - Bos taurus (Bovine) - TEKT3 gene May be a structural component of the sperm flagellum. Required for normal sperm mobility (By similarity). Indicus|evm.model.CM009509.1.505 Q2YDL7 CDRT4_BOVIN 98.780 0.815 1.21951 CDRT4 - CMT1A duplicated region transcript 4 protein homolog - Bos taurus (Bovine) - CDRT4 gene Indicus|evm.model.CM009509.1.506 Q29S14 TV23B_BOVIN 100.000 0.990431 1.00481 TVP23B - Golgi apparatus membrane protein TVP23 homolog B - Bos taurus (Bovine) - TVP23B gene integral component of Golgi membrane, protein secretion, vesicle-mediated transport Indicus|evm.model.CM009509.1.507 O95170 CDRT1_HUMAN 75.332 0.623041 1.44282 CDRT1 - CMT1A duplicated region transcript 1 protein - Homo sapiens (Human) - CDRT1 gene Indicus|evm.model.CM009509.1.508 Q309B1 TR16L_HUMAN 75.434 0.616071 1.6092 TRIM16L - Tripartite motif-containing protein 16-like protein - Homo sapiens (Human) - TRIM16L gene cytosol, plasma membrane Indicus|evm.model.CM009509.1.509 Q9HBT8 Z286A_HUMAN 87.716 0.88586 1.12668 ZNF286A - Zinc finger protein 286A - Homo sapiens (Human) - ZNF286A gene May be involved in transcriptional regulation. Indicus|evm.model.CM009509.1.510 Q9P2J8 ZN624_HUMAN 88.679 0.997644 0.981503 ZNF624 - Zinc finger protein 624 - Homo sapiens (Human) - ZNF624 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009509.1.511 Q9HBT7 ZN287_HUMAN 86.894 0.997361 0.996058 ZNF287 - Zinc finger protein 287 - Homo sapiens (Human) - ZNF287 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009509.1.512 Q8NAA5 LR75A_HUMAN 80.312 0.901163 1 LRRC75A - Leucine-rich repeat-containing protein 75A - Homo sapiens (Human) - LRRC75A gene cytoplasm Indicus|evm.model.CM009509.1.513 Q9WTR1 TRPV2_MOUSE 77.064 0.997347 0.997354 Trpv2 - Transient receptor potential cation channel subfamily V member 2 - Mus musculus (Mouse) - Trpv2 gene Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Indicus|evm.model.CM009509.1.514 P0CG53 UBB_BOVIN 100.000 0.993464 1.00328 UBB - Polyubiquitin-B precursor - Bos taurus (Bovine) - UBB gene Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Indicus|evm.model.CM009509.1.515 P84089 ERH_MOUSE 80.769 0.902655 1.08654 Erh - Enhancer of rudimentary homolog - Mus musculus (Mouse) - Erh gene May have a role in the cell cycle. Indicus|evm.model.CM009509.1.516 Q9CXS4 CENPV_MOUSE 96.296 0.893333 0.595238 Cenpv - Centromere protein V - Mus musculus (Mouse) - Cenpv gene Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis. Indicus|evm.model.CM009509.1.517 A6QQ24 PIGL_BOVIN 99.209 0.992126 1.00395 PIGL - N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase - Bos taurus (Bovine) - PIGL gene Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity). Indicus|evm.model.CM009509.1.518 O75376 NCOR1_HUMAN 89.923 0.999185 1.00615 NCOR1 - Nuclear receptor corepressor 1 - Homo sapiens (Human) - NCOR1 gene Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Indicus|evm.model.CM009509.1.519 Q6DKK2 TTC19_HUMAN 81.071 0.894231 0.821053 TTC19 - Tetratricopeptide repeat protein 19, mitochondrial precursor - Homo sapiens (Human) - TTC19 gene Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1 (PubMed:21278747, PubMed:28673544). Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity (PubMed:28673544). Indicus|evm.model.CM009509.1.520 Q19AV6 ZSWM7_HUMAN 86.232 0.938356 1.04286 ZSWIM7 - Zinc finger SWIM domain-containing protein 7 - Homo sapiens (Human) - ZSWIM7 gene Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Indicus|evm.model.CM009509.1.521 Q1LZD0 AA2BR_BOVIN 90.934 0.994521 1.0994 ADORA2B - Adenosine receptor A2b - Bos taurus (Bovine) - ADORA2B gene Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Indicus|evm.model.CM009509.1.522 Q5M775 CYTSB_HUMAN 79.794 0.978723 1.01217 SPECC1 - Cytospin-B - Homo sapiens (Human) - SPECC1 gene cytosol, fibrillar center, filamentous actin, intracellular membrane-bounded organelle, microtubule organizing center, nucleoplasm, actin cytoskeleton organization Indicus|evm.model.CM009509.1.524 O43572 AKA10_HUMAN 92.587 0.385251 2.56042 AKAP10 - A-kinase anchor protein 10, mitochondrial precursor - Homo sapiens (Human) - AKAP10 gene Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). Indicus|evm.model.CM009509.1.525 P30838 AL3A1_HUMAN 87.333 0.412684 2.40177 ALDH3A1 - Aldehyde dehydrogenase, dimeric NADP-preferring - Homo sapiens (Human) - ALDH3A1 gene ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). Indicus|evm.model.CM009509.1.526 P51648 AL3A2_HUMAN 85.655 0.950495 1.04124 ALDH3A2 - Aldehyde dehydrogenase family 3 member A2 - Homo sapiens (Human) - ALDH3A2 gene Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). Indicus|evm.model.CM009509.1.527 Q96FL8 S47A1_HUMAN 78.629 0.736215 1.17719 SLC47A1 - Multidrug and toxin extrusion protein 1 - Homo sapiens (Human) - SLC47A1 gene Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. Indicus|evm.model.CM009509.1.528 Q08DF2 RN112_BOVIN 97.297 0.575663 1.0207 RNF112 - RING finger protein 112 - Bos taurus (Bovine) - RNF112 gene E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density. Indicus|evm.model.CM009509.1.529 P55918 MFAP4_BOVIN 100.000 0.992188 1.00392 MFAP4 - Microfibril-associated glycoprotein 4 precursor - Bos taurus (Bovine) - MFAP4 gene Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. Indicus|evm.model.CM009509.1.530 A5PKJ4 MK07_BOVIN 99.872 0.997442 1.00128 MAPK7 - Mitogen-activated protein kinase 7 - Bos taurus (Bovine) - MAPK7 gene Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity). Indicus|evm.model.CM009509.1.531 Q9UPM9 B9D1_HUMAN 94.608 0.990244 1.0049 B9D1 - B9 domain-containing protein 1 - Homo sapiens (Human) - B9D1 gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). Indicus|evm.model.CM009509.1.532 Q9Z1Z3 EPN2_RAT 81.987 0.996599 1.00858 Epn2 - Epsin-2 - Rattus norvegicus (Rat) - Epn2 gene Plays a role in the formation of clathrin-coated invaginations and endocytosis. Indicus|evm.model.CM009509.1.534 A6QLK6 GRAP_BOVIN 99.539 0.990826 1.00461 GRAP - GRB2-related adapter protein - Bos taurus (Bovine) - GRAP gene Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. Indicus|evm.model.CM009509.1.535 Q6R4Q5 SC5AA_BOVIN 99.628 0.890365 0.504188 SLC5A10 - Sodium/glucose cotransporter 5 - Bos taurus (Bovine) - SLC5A10 gene High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose. Indicus|evm.model.CM009509.1.536 A6ND36 FA83G_HUMAN 79.880 0.997555 0.993925 FAM83G - Protein FAM83G - Homo sapiens (Human) - FAM83G gene May regulate the bone morphogenetic proteins (BMP) pathway. Indicus|evm.model.CM009509.1.537 Q6R4Q5 SC5AA_BOVIN 100.000 0.946309 0.499162 SLC5A10 - Sodium/glucose cotransporter 5 - Bos taurus (Bovine) - SLC5A10 gene High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose. Indicus|evm.model.CM009509.1.538 A2VDS0 KPRB_BOVIN 100.000 0.994595 1.00271 PRPSAP2 - Phosphoribosyl pyrophosphate synthase-associated protein 2 - Bos taurus (Bovine) - PRPSAP2 gene Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. Indicus|evm.model.CM009509.1.539 Q91ZK5 ACTB_SIGHI 57.547 0.628049 0.437333 ACTB - Actin, cytoplasmic 1 - Sigmodon hispidus (Hispid cotton rat) - ACTB gene Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Indicus|evm.model.CM009509.1.540 Q5E9P9 GLYC_BOVIN 99.793 0.995876 1.00207 SHMT1 - Serine hydroxymethyltransferase, cytosolic - Bos taurus (Bovine) - SHMT1 gene Interconversion of serine and glycine. Indicus|evm.model.CM009509.1.541 Q8TEV9 SMCR8_HUMAN 81.130 0.997735 0.942369 SMCR8 - Guanine nucleotide exchange protein SMCR8 - Homo sapiens (Human) - SMCR8 gene Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27193190, PubMed:27103069, PubMed:27559131, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). Indicus|evm.model.CM009509.1.542 Q13472 TOP3A_HUMAN 85.373 0.998006 1.002 TOP3A - DNA topoisomerase 3-alpha - Homo sapiens (Human) - TOP3A gene Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity (PubMed:30057030). It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2 (PubMed:29290614). Indicus|evm.model.CM009509.1.543 Q96C03 MID49_HUMAN 80.088 0.970149 1.03304 MIEF2 - Mitochondrial dynamics protein MID49 - Homo sapiens (Human) - MIEF2 gene Mitochondrial outer membrane protein which regulates mitochondrial organization (PubMed:29361167). It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. Indicus|evm.model.CM009509.1.544 Q13045 FLII_HUMAN 95.073 0.998384 0.975571 FLII - Protein flightless-1 homolog - Homo sapiens (Human) - FLII gene May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. Indicus|evm.model.CM009509.1.545 Q15334 L2GL1_HUMAN 90.453 0.984762 0.986842 LLGL1 - Lethal(2) giant larvae protein homolog 1 - Homo sapiens (Human) - LLGL1 gene Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. Indicus|evm.model.CM009509.1.546 E1BH29 ALKB5_BOVIN 100.000 0.993421 0.771574 ALKBH5 - RNA demethylase ALKBH5 - Bos taurus (Bovine) - ALKBH5 gene Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Indicus|evm.model.CM009509.1.547 Q9UKN7 MYO15_HUMAN 82.148 0.993687 0.987252 MYO15A - Unconventional myosin-XV - Homo sapiens (Human) - MYO15A gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity). Indicus|evm.model.CM009509.1.548 Q58D56 DRG2_BOVIN 100.000 0.994521 1.00275 DRG2 - Developmentally-regulated GTP-binding protein 2 - Bos taurus (Bovine) - DRG2 gene Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Indicus|evm.model.CM009509.1.549 Q8IVV7 GID4_HUMAN 99.078 0.990826 0.726667 GID4 - Glucose-induced degradation protein 4 homolog - Homo sapiens (Human) - GID4 gene Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (Probable) (PubMed:29911972). Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp (PubMed:29632410). Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue (PubMed:29632410). Indicus|evm.model.CM009509.1.550 Q1LZ96 ATPF2_BOVIN 100.000 0.993103 1.00346 ATPAF2 - ATP synthase mitochondrial F1 complex assembly factor 2 precursor - Bos taurus (Bovine) - ATPAF2 gene May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase). Indicus|evm.model.CM009509.1.551 Q9H069 DRC3_HUMAN 82.103 0.985428 1.04971 DRC3 - Dynein regulatory complex subunit 3 - Homo sapiens (Human) - DRC3 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Indicus|evm.model.CM009509.1.552 Q6ZVM7 TM1L2_HUMAN 88.372 0.996071 1.00394 TOM1L2 - TOM1-like protein 2 - Homo sapiens (Human) - TOM1L2 gene Probable role in protein transport. May regulate growth factor-induced mitogenic signaling. Indicus|evm.model.CM009509.1.553 O97676 SRBP1_PIG 86.990 0.998256 0.996525 SREBF1 - Sterol regulatory element-binding protein 1 - Sus scrofa (Pig) - SREBF1 gene Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (By similarity). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). Indicus|evm.model.CM009509.1.554 Q7Z5J4 RAI1_HUMAN 85.804 0.99841 0.990031 RAI1 - Retinoic acid-induced protein 1 - Homo sapiens (Human) - RAI1 gene Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. Indicus|evm.model.CM009509.1.556 Q7YRH6 PEMT_BOVIN 78.894 0.722222 1.08543 PEMT - Phosphatidylethanolamine N-methyltransferase - Bos taurus (Bovine) - PEMT gene Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC). Indicus|evm.model.CM009509.1.557 O35626 RASD1_MOUSE 86.071 0.99278 0.989286 Rasd1 - Dexamethasone-induced Ras-related protein 1 precursor - Mus musculus (Mouse) - Rasd1 gene Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity). Indicus|evm.model.CM009509.1.558 Q2KHX9 MED9_BOVIN 100.000 0.986301 1.0069 MED9 - Mediator of RNA polymerase II transcription subunit 9 - Bos taurus (Bovine) - MED9 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009509.1.559 Q9NPB1 NT5M_HUMAN 91.398 0.984043 0.824561 NT5M - 5'(3')-deoxyribonucleotidase, mitochondrial precursor - Homo sapiens (Human) - NT5M gene Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. Indicus|evm.model.CM009509.1.560 A6H7B5 CSN3_BOVIN 100.000 0.995283 1.00236 COPS3 - COP9 signalosome complex subunit 3 - Bos taurus (Bovine) - COPS3 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (By similarity). Indicus|evm.model.CM009509.1.561 Q3B7L5 FLCN_BOVIN 100.000 0.996552 1.00173 FLCN - Folliculin - Bos taurus (Bovine) - FLCN gene GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3. Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RRAGC/RagC or RRAGD/RagD, promoting the conversion to the GDP-bound state of RRAGC/RagC or RRAGD/RagD, and thereby activating the kinase activity of mTORC1. The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients. Acts as a key component for mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1. In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3. Upon amino acid restimulation, RRAGA/RagA (or RRAGB/RagB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3. Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3. Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (By similarity). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation. Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy. Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (By similarity). Indicus|evm.model.CM009509.1.562 E1BE10 PLD6_BOVIN 99.545 0.99095 1.00455 PLD6 - Mitochondrial cardiolipin hydrolase - Bos taurus (Bovine) - PLD6 gene Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low. In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (By similarity). Indicus|evm.model.CM009509.1.565 Q6WCQ1 MPRIP_HUMAN 90.612 0.209507 1.10829 MPRIP - Myosin phosphatase Rho-interacting protein - Homo sapiens (Human) - MPRIP gene Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. Indicus|evm.model.CM009509.1.566 O14836 TR13B_HUMAN 61.463 0.871795 0.798635 TNFRSF13B - Tumor necrosis factor receptor superfamily member 13B - Homo sapiens (Human) - TNFRSF13B gene Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. Indicus|evm.model.CM009509.1.567 P0C8Z3 UBP22_BOVIN 100.000 0.996117 1.00195 USP22 - Ubiquitin carboxyl-terminal hydrolase 22 - Bos taurus (Bovine) - USP22 gene Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity). Indicus|evm.model.CM009509.1.568 Q3T0R4 DRS7B_BOVIN 99.686 0.794486 1.22769 DHRS7B - Dehydrogenase/reductase SDR family member 7B - Bos taurus (Bovine) - DHRS7B gene Putative oxidoreductase. Indicus|evm.model.CM009509.1.569 A5D7N3 TMM11_BOVIN 100.000 0.989637 1.00521 TMEM11 - Transmembrane protein 11, mitochondrial - Bos taurus (Bovine) - TMEM11 gene Plays a role in mitochondrial morphogenesis. Indicus|evm.model.CM009509.1.571 A6QL79 NATD1_BOVIN 100.000 0.631148 1.07965 NATD1 - Protein NATD1 - Bos taurus (Bovine) - NATD1 gene Indicus|evm.model.CM009509.1.572 P46734 MP2K3_HUMAN 96.542 0.994253 1.00288 MAP2K3 - Dual specificity mitogen-activated protein kinase kinase 3 - Homo sapiens (Human) - MAP2K3 gene Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Indicus|evm.model.CM009509.1.573 O19110 TSPY1_BOVIN 75.342 0.857143 0.264984 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009509.1.574 O19110 TSPY1_BOVIN 60.000 0.407407 0.340694 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009509.1.575 Q4TZY1 KCJ12_BOVIN 99.532 0.995327 1.00234 KCNJ12 - ATP-sensitive inward rectifier potassium channel 12 - Bos taurus (Bovine) - KCNJ12 gene Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). Indicus|evm.model.CM009509.1.576 A8PUI7 SKA3_BOVIN 83.908 0.247126 0.863524 SKA3 - Spindle and kinetochore-associated protein 3 - Bos taurus (Bovine) - SKA3 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Indicus|evm.model.CM009509.1.577 Q9Y5J1 UTP18_HUMAN 85.072 0.966372 1.01619 UTP18 - U3 small nucleolar RNA-associated protein 18 homolog - Homo sapiens (Human) - UTP18 gene Involved in nucleolar processing of pre-18S ribosomal RNA. Indicus|evm.model.CM009509.1.578 Q05BQ5 MBTD1_HUMAN 98.089 0.99682 1.00159 MBTD1 - MBT domain-containing protein 1 - Homo sapiens (Human) - MBTD1 gene Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. Indicus|evm.model.CM009509.1.579 Q3T0Q4 NDKB_BOVIN 100.000 0.982609 0.756579 NME2 - Nucleoside diphosphate kinase B - Bos taurus (Bovine) - NME2 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (By similarity). Exhibits histidine protein kinase activity (PubMed:12486123). Indicus|evm.model.CM009509.1.580 P52175 NDKA2_BOVIN 100.000 0.947826 0.756579 NME1-2 - Nucleoside diphosphate kinase A 2 - Bos taurus (Bovine) - NME1-2 gene Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. Indicus|evm.model.CM009509.1.581 P52175 NDKA2_BOVIN 97.727 0.589041 0.480263 NME1-2 - Nucleoside diphosphate kinase A 2 - Bos taurus (Bovine) - NME1-2 gene Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. Indicus|evm.model.CM009509.1.582 O60271 JIP4_HUMAN 94.378 0.998486 1 SPAG9 - C-Jun-amino-terminal kinase-interacting protein 4 - Homo sapiens (Human) - SPAG9 gene The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). Indicus|evm.model.CM009509.1.583 P50616 TOB1_HUMAN 97.681 0.994152 0.991304 TOB1 - Protein Tob1 - Homo sapiens (Human) - TOB1 gene Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). Indicus|evm.model.CM009509.1.584 Q08E66 WFKN2_BOVIN 99.826 0.996522 1.00174 WFIKKN2 - WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 precursor - Bos taurus (Bovine) - WFIKKN2 gene Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity). Indicus|evm.model.CM009509.1.585 Q53H64 AK40L_HUMAN 83.168 0.684932 1.2807 ANKRD40CL - Putative ANKRD40 C-terminal-like protein - Homo sapiens (Human) - ANKRD40CL gene Indicus|evm.model.CM009509.1.586 Q3SX41 LC7L3_BOVIN 100.000 0.913978 1.07639 LUC7L3 - Luc7-like protein 3 - Bos taurus (Bovine) - LUC7L3 gene Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity). Indicus|evm.model.CM009509.1.587 Q6AI12 ANR40_HUMAN 95.380 0.994536 0.994565 ANKRD40 - Ankyrin repeat domain-containing protein 40 - Homo sapiens (Human) - ANKRD40 gene Indicus|evm.model.CM009509.1.588 O15438 MRP3_HUMAN 84.957 0.998693 1.00196 ABCC3 - ATP-binding cassette sub-family C member 3 - Homo sapiens (Human) - ABCC3 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813). Indicus|evm.model.CM009509.1.589 O43497 CAC1G_HUMAN 94.304 0.994103 0.998738 CACNA1G - Voltage-dependent T-type calcium channel subunit alpha-1G - Homo sapiens (Human) - CACNA1G gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Indicus|evm.model.CM009509.1.590 Q8TB22 SPT20_HUMAN 93.020 0.996203 1.00509 SPATA20 - Spermatogenesis-associated protein 20 precursor - Homo sapiens (Human) - SPATA20 gene May play a role in fertility regulation. Indicus|evm.model.CM009509.1.591 Q9H201 EPN3_HUMAN 83.851 0.99686 1.00791 EPN3 - Epsin-3 - Homo sapiens (Human) - EPN3 gene clathrin vesicle coat, clathrin-coated vesicle, endosome, extracellular exosome, extrinsic component of plasma membrane, intracellular membrane-bounded organelle, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane Indicus|evm.model.CM009509.1.592 Q8TBZ2 MYBPP_HUMAN 74.153 0.982273 1.01267 MYCBPAP - MYCBP-associated protein - Homo sapiens (Human) - MYCBPAP gene May play a role in spermatogenesis. May be involved in synaptic processes (By similarity). Indicus|evm.model.CM009509.1.593 A5D7B1 RSAD1_BOVIN 100.000 0.995485 1.00226 RSAD1 - Radical S-adenosyl methionine domain-containing protein 1, mitochondrial precursor - Bos taurus (Bovine) - RSAD1 gene May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity). Indicus|evm.model.CM009509.1.594 Q17QJ1 ACSF2_BOVIN 100.000 0.996753 1.00163 ACSF2 - Medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor - Bos taurus (Bovine) - ACSF2 gene Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation. Indicus|evm.model.CM009509.1.595 Q5E9X4 LRC59_BOVIN 100.000 0.993485 1.00327 LRRC59 - Leucine-rich repeat-containing protein 59 - Bos taurus (Bovine) - LRRC59 gene Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity). Indicus|evm.model.CM009509.1.596 Q5NVA9 EME1_PONAB 72.806 0.996522 1 EME1 - Crossover junction endonuclease EME1 - Pongo abelii (Sumatran orangutan) - EME1 gene Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity). Indicus|evm.model.CM009509.1.597 Q32PC3 RM27_BOVIN 99.324 0.986577 1.00676 MRPL27 - 39S ribosomal protein L27, mitochondrial precursor - Bos taurus (Bovine) - MRPL27 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009509.1.598 Q5QQ50 XYLT2_CANLF 95.260 0.997688 1 XYLT2 - Xylosyltransferase 2 - Canis lupus familiaris (Dog) - XYLT2 gene Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN (By similarity). Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity). Indicus|evm.model.CM009509.1.599 Q6UXU6 TMM92_HUMAN 56.098 0.419355 2.33962 TMEM92 - Transmembrane protein 92 precursor - Homo sapiens (Human) - TMEM92 gene nucleoplasm Indicus|evm.model.CM009509.1.600 Q99880 H2B1L_HUMAN 93.651 0.984252 1.00794 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009509.1.601 P02453 CO1A1_BOVIN 98.975 0.99862 0.990431 COL1A1 - Collagen alpha-1(I) chain precursor - Bos taurus (Bovine) - COL1A1 gene Type I collagen is a member of group I collagen (fibrillar forming collagen). Indicus|evm.model.CM009509.1.602 Q16586 SGCA_HUMAN 88.918 0.994859 1.00517 SGCA - Alpha-sarcoglycan precursor - Homo sapiens (Human) - SGCA gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Indicus|evm.model.CM009509.1.603 Q96SB3 NEB2_HUMAN 96.276 0.505671 1.29498 PPP1R9B - Neurabin-2 - Homo sapiens (Human) - PPP1R9B gene Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration. Indicus|evm.model.CM009509.1.604 Q15119 PDK2_HUMAN 98.034 0.995098 1.00246 PDK2 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial precursor - Homo sapiens (Human) - PDK2 gene Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. Indicus|evm.model.CM009509.1.606 F1MMS9 ITA3_BOVIN 100.000 0.998097 1.00095 ITGA3 - Integrin alpha-3 precursor - Bos taurus (Bovine) - ITGA3 gene Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Indicus|evm.model.CM009509.1.607 O60479 DLX3_HUMAN 99.303 0.993056 1.00348 DLX3 - Homeobox protein DLX-3 - Homo sapiens (Human) - DLX3 gene Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Indicus|evm.model.CM009509.1.608 Q92988 DLX4_HUMAN 83.750 0.991489 0.979167 DLX4 - Homeobox protein DLX-4 - Homo sapiens (Human) - DLX4 gene May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis. Indicus|evm.model.CM009509.1.610 Q6ECK6 TKN4_RABIT 61.429 0.663366 1.01 TAC4 - Tachykinin-4 precursor - Oryctolagus cuniculus (Rabbit) - TAC4 gene Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Indicus|evm.model.CM009509.1.611 O95251 KAT7_HUMAN 99.673 0.996732 1.00164 KAT7 - Histone acetyltransferase KAT7 - Homo sapiens (Human) - KAT7 gene Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). Indicus|evm.model.CM009509.1.612 Q9C073 F117A_HUMAN 92.784 0.962687 0.887417 FAM117A - Protein FAM117A - Homo sapiens (Human) - FAM117A gene Indicus|evm.model.CM009509.1.613 Q8MII5 S35B1_BOVIN 100.000 0.901685 1.10559 SLC35B1 - Solute carrier family 35 member B1 - Bos taurus (Bovine) - SLC35B1 gene Probable sugar transporter. Indicus|evm.model.CM009509.1.614 Q5NVK7 SPOP_PONAB 100.000 0.994667 1.00267 SPOP - Speckle-type POZ protein - Pongo abelii (Sumatran orangutan) - SPOP gene Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability. Indicus|evm.model.CM009509.1.615 O95157 NXPH3_HUMAN 94.872 0.924603 1 NXPH3 - Neurexophilin-3 precursor - Homo sapiens (Human) - NXPH3 gene May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity). Indicus|evm.model.CM009509.1.616 P08138 TNR16_HUMAN 95.571 0.995349 1.00703 NGFR - Tumor necrosis factor receptor superfamily member 16 precursor - Homo sapiens (Human) - NGFR gene Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Indicus|evm.model.CM009509.1.617 P35232 PHB_HUMAN 100.000 0.992674 1.00368 PHB - Prohibitin - Homo sapiens (Human) - PHB gene Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). Indicus|evm.model.CM009509.1.618 Q9Y2D9 ZN652_HUMAN 96.382 0.996716 1.00495 ZNF652 - Zinc finger protein 652 - Homo sapiens (Human) - ZNF652 gene Functions as a transcriptional repressor. Indicus|evm.model.CM009509.1.620 Q8TCT1 PHOP1_HUMAN 90.769 0.739255 1.30712 PHOSPHO1 - Phosphoethanolamine/phosphocholine phosphatase - Homo sapiens (Human) - PHOSPHO1 gene Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Indicus|evm.model.CM009509.1.621 Q9P2A4 ABI3_HUMAN 82.466 0.988889 0.983607 ABI3 - ABI gene family member 3 - Homo sapiens (Human) - ABI3 gene May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. Indicus|evm.model.CM009509.1.622 P50154 GBGT2_BOVIN 100.000 0.971429 1.01449 GNGT2 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 precursor - Bos taurus (Bovine) - GNGT2 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009509.1.624 Q8NHY0 B4GN2_HUMAN 84.106 0.993407 0.803887 B4GALNT2 - Beta-1,4 N-acetylgalactosaminyltransferase 2 - Homo sapiens (Human) - B4GALNT2 gene Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. Indicus|evm.model.CM009509.1.625 Q9NZI8 IF2B1_HUMAN 97.054 0.996491 0.987868 IGF2BP1 - Insulin-like growth factor 2 mRNA-binding protein 1 - Homo sapiens (Human) - IGF2BP1 gene RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. Indicus|evm.model.CM009509.1.626 P09680 GIP_BOVIN 100.000 0.230337 4.2381 GIP - Gastric inhibitory polypeptide - Bos taurus (Bovine) - GIP gene Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. Indicus|evm.model.CM009509.1.627 Q96H20 SNF8_HUMAN 99.225 0.992278 1.00388 SNF8 - Vacuolar-sorting protein SNF8 - Homo sapiens (Human) - SNF8 gene Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Indicus|evm.model.CM009509.1.628 P32876 AT5G1_BOVIN 100.000 0.350649 2.83088 ATP5MC1 - ATP synthase F(0) complex subunit C1, mitochondrial precursor - Bos taurus (Bovine) - ATP5MC1 gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. Indicus|evm.model.CM009509.1.629 O18737 CACO2_BOVIN 100.000 0.995565 1.00222 CALCOCO2 - Calcium-binding and coiled-coil domain-containing protein 2 - Bos taurus (Bovine) - CALCOCO2 gene Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity). Indicus|evm.model.CM009509.1.630 Q8N841 TTLL6_HUMAN 76.860 0.997622 0.997628 TTLL6 - Tubulin polyglutamylase TTLL6 - Homo sapiens (Human) - TTLL6 gene Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS. Indicus|evm.model.CM009509.1.631 Q92826 HXB13_HUMAN 93.333 0.993007 1.00704 HOXB13 - Homeobox protein Hox-B13 - Homo sapiens (Human) - HOXB13 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536). Indicus|evm.model.CM009509.1.632 P17482 HXB9_HUMAN 99.600 0.992032 1.004 HOXB9 - Homeobox protein Hox-B9 - Homo sapiens (Human) - HOXB9 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009509.1.633 P09632 HXB8_MOUSE 99.296 0.615721 0.942387 Hoxb8 - Homeobox protein Hox-B8 - Mus musculus (Mouse) - Hoxb8 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009509.1.634 Q9TT89 HXB7_BOVIN 97.696 0.86747 1.14747 HOXB7 - Homeobox protein Hox-B7 - Bos taurus (Bovine) - HOXB7 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009509.1.635 P09023 HXB6_MOUSE 97.842 0.978723 0.629464 Hoxb6 - Homeobox protein Hox-B6 - Mus musculus (Mouse) - Hoxb6 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009509.1.636 P09067 HXB5_HUMAN 99.194 0.908088 1.01115 HOXB5 - Homeobox protein Hox-B5 - Homo sapiens (Human) - HOXB5 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009509.1.637 Q08DG5 HXB4_BOVIN 99.602 0.992063 1.00398 HOXB4 - Homeobox protein Hox-B4 - Bos taurus (Bovine) - HOXB4 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009509.1.638 P14651 HXB3_HUMAN 93.968 0.995316 0.990719 HOXB3 - Homeobox protein Hox-B3 - Homo sapiens (Human) - HOXB3 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009509.1.639 P14652 HXB2_HUMAN 85.714 0.994366 0.997191 HOXB2 - Homeobox protein Hox-B2 - Homo sapiens (Human) - HOXB2 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Indicus|evm.model.CM009509.1.640 A2T7J2 HXB1_PONPY 88.742 0.993399 1.00664 HOXB1 - Homeobox protein Hox-B1 - Pongo pygmaeus (Bornean orangutan) - HOXB1 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (By similarity). Indicus|evm.model.CM009509.1.641 Q2HJ94 DNJA2_BOVIN 88.754 0.993865 0.791262 DNAJA2 - DnaJ homolog subfamily A member 2 precursor - Bos taurus (Bovine) - DNAJA2 gene Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Indicus|evm.model.CM009509.1.642 Q86WV1 SKAP1_HUMAN 83.051 0.99435 0.986072 SKAP1 - Src kinase-associated phosphoprotein 1 - Homo sapiens (Human) - SKAP1 gene Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. Indicus|evm.model.CM009509.1.643 Q08DD7 SNX11_BOVIN 100.000 0.99262 1.0037 SNX11 - Sorting nexin-11 - Bos taurus (Bovine) - SNX11 gene Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Indicus|evm.model.CM009509.1.644 P83917 CBX1_MOUSE 100.000 0.989247 1.00541 Cbx1 - Chromobox protein homolog 1 - Mus musculus (Mouse) - Cbx1 gene Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Indicus|evm.model.CM009509.1.645 A5D7E9 NF2L1_BOVIN 98.579 0.997419 1.01573 NFE2L1 - Endoplasmic reticulum membrane sensor NFE2L1 - Bos taurus (Bovine) - NFE2L1 gene Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (By similarity). Indicus|evm.model.CM009509.1.646 Q9P299 COPZ2_HUMAN 95.402 0.856436 0.961905 COPZ2 - Coatomer subunit zeta-2 - Homo sapiens (Human) - COPZ2 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. Indicus|evm.model.CM009509.1.647 Q96JB5 CK5P3_HUMAN 90.316 0.996047 1 CDK5RAP3 - CDK5 regulatory subunit-associated protein 3 - Homo sapiens (Human) - CDK5RAP3 gene Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PubMed:23152784, PubMed:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). Required for liver development (By similarity). Indicus|evm.model.CM009509.1.648 Q3T183 PR15L_BOVIN 100.000 0.980198 1.01 PRR15L - Proline-rich protein 15-like protein - Bos taurus (Bovine) - PRR15L gene Indicus|evm.model.CM009509.1.649 Q5E9K3 PNPO_BOVIN 100.000 0.992366 1.00383 PNPO - Pyridoxine-5'-phosphate oxidase - Bos taurus (Bovine) - PNPO gene Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). Indicus|evm.model.CM009509.1.650 Q5E9U0 SP2_BOVIN 100.000 0.972843 1.02121 SP2 - Transcription factor Sp2 - Bos taurus (Bovine) - SP2 gene Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Indicus|evm.model.CM009509.1.651 Q3SY56 SP6_HUMAN 96.011 0.994681 1 SP6 - Transcription factor Sp6 - Homo sapiens (Human) - SP6 gene Promotes cell proliferation. Indicus|evm.model.CM009509.1.652 Q96FV2 SCRN2_HUMAN 87.591 0.962441 1.00235 SCRN2 - Secernin-2 - Homo sapiens (Human) - SCRN2 gene extracellular exosome Indicus|evm.model.CM009509.1.653 Q96FV0 LRC46_HUMAN 79.630 0.993846 1.01246 LRRC46 - Leucine-rich repeat-containing protein 46 - Homo sapiens (Human) - LRRC46 gene Indicus|evm.model.CM009509.1.654 Q3MHY7 RM10_BOVIN 100.000 0.992395 1.00382 MRPL10 - 39S ribosomal protein L10, mitochondrial precursor - Bos taurus (Bovine) - MRPL10 gene large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, ribonucleoprotein complex, structural constituent of ribosome, translation Indicus|evm.model.CM009509.1.655 Q9BZF2 OSBL7_HUMAN 92.874 0.997613 0.995249 OSBPL7 - Oxysterol-binding protein-related protein 7 - Homo sapiens (Human) - OSBPL7 gene autophagosome, cytosol, intracellular membrane-bounded organelle, membrane, nucleoplasm, perinuclear endoplasmic reticulum, plasma membrane, cholesterol binding, sterol binding, sterol transporter activity Indicus|evm.model.CM009509.1.657 Q9UL17 TBX21_HUMAN 90.093 0.996248 0.996262 TBX21 - T-box transcription factor TBX21 - Homo sapiens (Human) - TBX21 gene Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity). Indicus|evm.model.CM009509.1.658 Q14974 IMB1_HUMAN 99.429 0.631313 1.58219 KPNB1 - Importin subunit beta-1 - Homo sapiens (Human) - KPNB1 gene Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus. Indicus|evm.model.CM009509.1.659 P30050 RL12_HUMAN 65.278 0.592391 1.11515 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Indicus|evm.model.CM009509.1.660 P55786 PSA_HUMAN 98.441 0.96748 0.936888 NPEPPS - Puromycin-sensitive aminopeptidase - Homo sapiens (Human) - NPEPPS gene Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. Indicus|evm.model.CM009509.1.661 Q3T142 RM45_BOVIN 99.346 0.993485 1.00327 MRPL45 - 39S ribosomal protein L45, mitochondrial precursor - Bos taurus (Bovine) - MRPL45 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Indicus|evm.model.CM009509.1.662 Q6PRD1 GP179_HUMAN 72.575 0.982874 1.01141 GPR179 - Probable G-protein coupled receptor 179 precursor - Homo sapiens (Human) - GPR179 gene Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. Indicus|evm.model.CM009509.1.663 O14512 SOCS7_HUMAN 97.423 0.897356 1.10671 SOCS7 - Suppressor of cytokine signaling 7 - Homo sapiens (Human) - SOCS7 gene Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Indicus|evm.model.CM009509.1.664 Q9P227 RHG23_HUMAN 93.065 0.612871 0.677398 ARHGAP23 - Rho GTPase-activating protein 23 - Homo sapiens (Human) - ARHGAP23 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009509.1.666 Q9C0H9 SRCN1_HUMAN 94.132 0.965517 1.0541 SRCIN1 - SRC kinase signaling inhibitor 1 - Homo sapiens (Human) - SRCIN1 gene Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. Indicus|evm.model.CM009509.1.667 A6NHQ4 EPOP_HUMAN 81.217 0.992105 1.00264 EPOP - Elongin BC and Polycomb repressive complex 2-associated protein - Homo sapiens (Human) - EPOP gene Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. Indicus|evm.model.CM009509.1.668 P55198 AF17_HUMAN 96.660 0.94635 1.04026 MLLT6 - Protein AF-17 - Homo sapiens (Human) - MLLT6 gene nucleus, histone binding, nucleosome binding, positive regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated Indicus|evm.model.CM009509.1.669 B1AR13 CISD3_MOUSE 85.217 0.890625 0.934307 Cisd3 - CDGSH iron-sulfur domain-containing protein 3, mitochondrial precursor - Mus musculus (Mouse) - Cisd3 gene Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function. Indicus|evm.model.CM009509.1.670 P35227 PCGF2_HUMAN 96.512 0.994203 1.00291 PCGF2 - Polycomb group RING finger protein 2 - Homo sapiens (Human) - PCGF2 gene Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Indicus|evm.model.CM009509.1.671 P33672 PSB3_BOVIN 100.000 0.990291 1.00488 PSMB3 - Proteasome subunit beta type-3 - Bos taurus (Bovine) - PSMB3 gene Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Indicus|evm.model.CM009509.1.672 Q80XI4 PI42B_MOUSE 99.519 0.995204 1.0024 Pip4k2b - Phosphatidylinositol 5-phosphate 4-kinase type-2 beta - Mus musculus (Mouse) - Pip4k2b gene Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. In collaboration with PIP4K2A, has a role in mediating autophagy in times of nutrient stress (PubMed:29727621). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:29727621). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (By similarity). Indicus|evm.model.CM009509.1.673 Q9NXE8 CWC25_HUMAN 93.176 0.995305 1.00235 CWC25 - Pre-mRNA-splicing factor CWC25 homolog - Homo sapiens (Human) - CWC25 gene Involved in pre-mRNA splicing as component of the spliceosome. Indicus|evm.model.CM009509.1.674 A8MV24 CQ098_HUMAN 81.818 0.987097 1.00649 C17orf98 - Uncharacterized protein C17orf98 - Homo sapiens (Human) - C17orf98 gene Indicus|evm.model.CM009509.1.675 P62832 RL23_RAT 100.000 0.985816 1.00714 Rpl23 - 60S ribosomal protein L23 - Rattus norvegicus (Rat) - Rpl23 gene cytoplasm, cytosolic large ribosomal subunit, nucleolus, nucleoplasm, postsynaptic density, protein-containing complex, ribosome, large ribosomal subunit rRNA binding, structural constituent of ribosome, transcription coactivator binding Indicus|evm.model.CM009509.1.676 Q3B7M5 LASP1_BOVIN 100.000 0.992337 1.00385 LASP1 - LIM and SH3 domain protein 1 - Bos taurus (Bovine) - LASP1 gene Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). Indicus|evm.model.CM009509.1.678 Q8IUK5 PLDX1_HUMAN 89.400 0.996008 1.002 PLXDC1 - Plexin domain-containing protein 1 precursor - Homo sapiens (Human) - PLXDC1 gene Plays a critical role in endothelial cell capillary morphogenesis. Indicus|evm.model.CM009509.1.679 P19517 CACB1_RABIT 96.008 0.756369 1.19847 CACNB1 - Voltage-dependent L-type calcium channel subunit beta-1 - Oryctolagus cuniculus (Rabbit) - CACNB1 gene Regulatory subunit of L-type calcium channels (PubMed:7509046). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (PubMed:7509046). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity). Indicus|evm.model.CM009509.1.680 Q6P068 ARL5C_MOUSE 64.029 0.948276 0.648045 Arl5c - ADP-ribosylation factor-like protein 5C - Mus musculus (Mouse) - Arl5c gene Binds and exchanges GTP and GDP. Indicus|evm.model.CM009509.1.681 P84100 RL19_RAT 100.000 0.840426 0.959184 Rpl19 - 60S ribosomal protein L19 - Rattus norvegicus (Rat) - Rpl19 gene cytosolic large ribosomal subunit, polysomal ribosome, synapse, 5.8S rRNA binding, large ribosomal subunit rRNA binding, RNA binding, structural constituent of ribosome, cytoplasmic translation, liver regeneration Indicus|evm.model.CM009509.1.682 Q8R1B0 STAC2_MOUSE 95.588 0.99511 1.00245 Stac2 - SH3 and cysteine-rich domain-containing protein 2 - Mus musculus (Mouse) - Stac2 gene Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity (PubMed:29467163). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:25548159, PubMed:29363593). Indicus|evm.model.CM009509.1.683 Q7T2U9 TFCP2_CHICK 49.556 0.91886 0.919355 TFCP2 - Transcription factor CP2 - Gallus gallus (Chicken) - TFCP2 gene Binds the B-response element 5'-CAAGTCCAGGCAAGT-3' of the ENS1/ERNI promoter. May be the major transcription activator thus being essential for its expression. Indicus|evm.model.CM009509.1.684 Q96IG2 FXL20_HUMAN 100.000 0.995423 1.00229 FBXL20 - F-box/LRR-repeat protein 20 - Homo sapiens (Human) - FBXL20 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). Indicus|evm.model.CM009509.1.685 Q15648 MED1_HUMAN 97.217 0.998731 0.996837 MED1 - Mediator of RNA polymerase II transcription subunit 1 - Homo sapiens (Human) - MED1 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Indicus|evm.model.CM009509.1.686 E1BB50 CDK12_BOVIN 99.602 0.991297 1 CDK12 - Cyclin-dependent kinase 12 - Bos taurus (Bovine) - CDK12 gene Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors (By similarity). Indicus|evm.model.CM009509.1.689 Q15784 NDF2_HUMAN 97.644 0.994778 1.00262 NEUROD2 - Neurogenic differentiation factor 2 - Homo sapiens (Human) - NEUROD2 gene Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity). Indicus|evm.model.CM009509.1.690 P07516 PPR1B_BOVIN 100.000 0.990148 1.00495 PPP1R1B - Protein phosphatase 1 regulatory subunit 1B - Bos taurus (Bovine) - PPP1R1B gene Inhibitor of protein-phosphatase 1. Indicus|evm.model.CM009509.1.691 Q14849 STAR3_HUMAN 94.643 0.995546 1.00899 STARD3 - StAR-related lipid transfer protein 3 - Homo sapiens (Human) - STARD3 gene Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544). Indicus|evm.model.CM009509.1.692 Q6T8D8 TELT_BOVIN 100.000 0.988024 1.00602 TCAP - Telethonin - Bos taurus (Bovine) - TCAP gene Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (By similarity). Indicus|evm.model.CM009509.1.693 P10938 PNMT_BOVIN 95.406 0.992958 1.00353 PNMT - Phenylethanolamine N-methyltransferase - Bos taurus (Bovine) - PNMT gene Converts noradrenaline to adrenaline. Indicus|evm.model.CM009509.1.694 A7YWP2 PGAP3_BOVIN 100.000 0.99375 1.00313 PGAP3 - Post-GPI attachment to proteins factor 3 precursor - Bos taurus (Bovine) - PGAP3 gene Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (By similarity). Indicus|evm.model.CM009509.1.695 O18735 ERBB2_CANLF 93.175 0.998408 0.997617 ERBB2 - Receptor tyrosine-protein kinase erbB-2 precursor - Canis lupus familiaris (Dog) - ERBB2 gene Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Indicus|evm.model.CM009509.1.696 Q148C8 MIEN1_BOVIN 100.000 0.982759 1.0087 MIEN1 - Migration and invasion enhancer 1 precursor - Bos taurus (Bovine) - MIEN1 gene Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity). Indicus|evm.model.CM009509.1.697 Q1RMW5 GRB7_BOVIN 99.624 0.996248 1.00188 GRB7 - Growth factor receptor-bound protein 7 - Bos taurus (Bovine) - GRB7 gene Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). Indicus|evm.model.CM009509.1.698 A2VDW9 IKZF3_BOVIN 99.803 0.945794 1.05108 IKZF3 - Zinc finger protein Aiolos - Bos taurus (Bovine) - IKZF3 gene Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner (By similarity). Indicus|evm.model.CM009509.1.699 Q6X784 ZPBP2_HUMAN 79.692 0.990826 0.967456 ZPBP2 - Zona pellucida-binding protein 2 precursor - Homo sapiens (Human) - ZPBP2 gene Is implicated in sperm-oocyte interaction during fertilization. Indicus|evm.model.CM009509.1.700 Q8TAX9 GSDMB_HUMAN 50.889 0.995495 1.08029 GSDMB - Gasdermin-B - Homo sapiens (Human) - GSDMB gene Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death (PubMed:32299851). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:32299851). Indicus|evm.model.CM009509.1.701 Q0VD15 ORML3_BOVIN 100.000 0.899408 1.10458 ORMDL3 - ORM1-like protein 3 - Bos taurus (Bovine) - ORMDL3 gene Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). Indicus|evm.model.CM009509.1.702 A6NJW4 LRR3C_HUMAN 85.827 0.992157 0.927273 LRRC3C - Leucine-rich repeat-containing protein 3C precursor - Homo sapiens (Human) - LRRC3C gene extracellular matrix, extracellular space Indicus|evm.model.CM009509.1.703 Q96QA5 GSDMA_HUMAN 89.013 0.995526 1.00449 GSDMA - Gasdermin-A - Homo sapiens (Human) - GSDMA gene This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death. Indicus|evm.model.CM009509.1.704 Q2KJ46 PSMD3_BOVIN 100.000 0.996262 1.00187 PSMD3 - 26S proteasome non-ATPase regulatory subunit 3 - Bos taurus (Bovine) - PSMD3 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Indicus|evm.model.CM009509.1.705 P35833 CSF3_BOVIN 100.000 0.989796 1.00513 CSF3 - Granulocyte colony-stimulating factor precursor - Bos taurus (Bovine) - CSF3 gene Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Indicus|evm.model.CM009509.1.706 O75448 MED24_HUMAN 96.562 0.99798 1.00101 MED24 - Mediator of RNA polymerase II transcription subunit 24 - Homo sapiens (Human) - MED24 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Indicus|evm.model.CM009509.1.707 Q28570 THA_SHEEP 100.000 0.720703 1.24878 THRA - Thyroid hormone receptor alpha - Ovis aries (Sheep) - THRA gene Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Indicus|evm.model.CM009509.1.708 Q08E02 NR1D1_BOVIN 98.214 0.970486 0.939641 NR1D1 - Nuclear receptor subfamily 1 group D member 1 - Bos taurus (Bovine) - NR1D1 gene Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner (By similarity). Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). Indicus|evm.model.CM009509.1.709 Q68DK7 MSL1_HUMAN 99.023 0.996748 1.00163 MSL1 - Male-specific lethal 1 homolog - Homo sapiens (Human) - MSL1 gene Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Indicus|evm.model.CM009509.1.710 A5D7H5 CASC3_BOVIN 99.858 0.997159 1.00142 CASC3 - Protein CASC3 - Bos taurus (Bovine) - CASC3 gene Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. Indicus|evm.model.CM009509.1.711 Q5R9B2 RPGFL_PONPY 97.588 0.687311 1.45175 RAPGEFL1 - Rap guanine nucleotide exchange factor-like 1 - Pongo pygmaeus (Bornean orangutan) - RAPGEFL1 gene Probable guanine nucleotide exchange factor (GEF). Indicus|evm.model.CM009509.1.712 Q8TF74 WIPF2_HUMAN 93.721 0.426295 2.28182 WIPF2 - WAS/WASL-interacting protein family member 2 - Homo sapiens (Human) - WIPF2 gene Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. Indicus|evm.model.CM009509.1.713 P10276 RARA_HUMAN 99.567 0.99568 1.00216 RARA - Retinoic acid receptor alpha - Homo sapiens (Human) - RARA gene Receptor for retinoic acid (PubMed:19850744, PubMed:16417524, PubMed:20215566). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:9267036, PubMed:19850744, PubMed:20215566). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). Indicus|evm.model.CM009509.1.714 Q8N144 CXD3_HUMAN 79.333 0.992982 0.969388 GJD3 - Gap junction delta-3 protein - Homo sapiens (Human) - GJD3 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009509.1.715 O46374 TOP2A_PIG 94.847 0.998695 1 TOP2A - DNA topoisomerase 2-alpha - Sus scrofa (Pig) - TOP2A gene Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (By similarity). May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity). Indicus|evm.model.CM009509.1.716 Q05716 IBP4_BOVIN 99.612 0.992278 1.00388 IGFBP4 - Insulin-like growth factor-binding protein 4 precursor - Bos taurus (Bovine) - IGFBP4 gene IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Indicus|evm.model.CM009509.1.717 Q32PJ7 TENS4_BOVIN 99.721 0.997211 1.0014 TNS4 - Tensin-4 precursor - Bos taurus (Bovine) - TNS4 gene May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton May promote apoptosis, via its cleavage by caspase-3. Cytoplasm, cytoskeleton. Indicus|evm.model.CM009509.1.718 Q5MD62 CCR7_BOVIN 99.196 0.994652 0.986807 CCR7 - C-C chemokine receptor type 7 precursor - Bos taurus (Bovine) - CCR7 gene Receptor for the MIP-3-beta chemokine. Indicus|evm.model.CM009509.1.719 Q969G3 SMCE1_HUMAN 96.594 0.995146 1.00243 SMARCE1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 - Homo sapiens (Human) - SMARCE1 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. Indicus|evm.model.CM009509.1.720 Q2KI75 KT222_BOVIN 100.000 0.993243 1.00339 KRT222 - Keratin-like protein KRT222 - Bos taurus (Bovine) - KRT222 gene Indicus|evm.model.CM009509.1.721 Q2M2I5 K1C24_HUMAN 78.450 0.753906 0.975238 KRT24 - Keratin, type I cytoskeletal 24 - Homo sapiens (Human) - KRT24 gene cytosol, extracellular exosome, cornification, keratinization Indicus|evm.model.CM009509.1.722 Q0P5J4 K1C25_BOVIN 100.000 0.995169 0.92 KRT25 - Keratin, type I cytoskeletal 25 - Bos taurus (Bovine) - KRT25 gene Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity). Indicus|evm.model.CM009509.1.723 A6H712 K1C26_BOVIN 100.000 0.995745 1.00213 KRT26 - Keratin, type I cytoskeletal 26 - Bos taurus (Bovine) - KRT26 gene Indicus|evm.model.CM009509.1.724 Q0P5J6 K1C27_BOVIN 100.000 0.995662 1.00217 KRT27 - Keratin, type I cytoskeletal 27 - Bos taurus (Bovine) - KRT27 gene Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). Indicus|evm.model.CM009509.1.725 P06394 K1C10_BOVIN 99.809 0.532045 1.86882 KRT10 - Keratin, type I cytoskeletal 10 - Bos taurus (Bovine) - KRT10 gene Plays a role in the establishment of the epidermal barrier on plantar skin. Indicus|evm.model.CM009509.1.726 Q28706 K1C12_RABIT 85.012 0.820202 1.20438 KRT12 - Keratin, type I cytoskeletal 12 - Oryctolagus cuniculus (Rabbit) - KRT12 gene Involved in corneal epithelium organization, integrity and corneal keratin expression. Indicus|evm.model.CM009509.1.727 A6QQQ9 K1C20_BOVIN 95.161 0.968586 0.452607 KRT20 - Keratin, type I cytoskeletal 20 - Bos taurus (Bovine) - KRT20 gene Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). Indicus|evm.model.CM009509.1.728 A6QQQ9 K1C20_BOVIN 88.971 0.918367 0.348341 KRT20 - Keratin, type I cytoskeletal 20 - Bos taurus (Bovine) - KRT20 gene Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). Indicus|evm.model.CM009509.1.729 Q9C075 K1C23_HUMAN 75.472 0.995238 0.995261 KRT23 - Keratin, type I cytoskeletal 23 - Homo sapiens (Human) - KRT23 gene cytosol, cornification, keratinization Indicus|evm.model.CM009509.1.730 Q6A163 K1C39_HUMAN 75.934 0.993802 0.985743 KRT39 - Keratin, type I cytoskeletal 39 - Homo sapiens (Human) - KRT39 gene May play a role in late hair differentiation. Indicus|evm.model.CM009509.1.731 A7YWM2 K1C40_BOVIN 98.083 0.990476 0.730858 KRT40 - Keratin, type I cytoskeletal 40 - Bos taurus (Bovine) - KRT40 gene May play a role in late hair differentiation. Indicus|evm.model.CM009509.1.732 Q24JX8 KRA31_BOVIN 98.980 0.979798 1.0102 KRTAP3-1 - Keratin-associated protein 3-1 - Bos taurus (Bovine) - KRTAP3-1 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). Indicus|evm.model.CM009509.1.733 P02440 KRB2C_SHEEP 81.410 0.986395 0.967105 Keratin, high-sulfur matrix protein, B2C - Ovis aries (Sheep) Indicus|evm.model.CM009509.1.734 P02440 KRB2C_SHEEP 87.179 0.987261 1.03289 Keratin, high-sulfur matrix protein, B2C - Ovis aries (Sheep) Indicus|evm.model.CM009509.1.735 P02439 KRB2B_SHEEP 92.500 0.952096 1.07051 Keratin, high-sulfur matrix protein, B2B - Ovis aries (Sheep) Indicus|evm.model.CM009509.1.736 P02442 KRA3_CAPHI 90.400 0.968504 0.962121 Keratin, high-sulfur matrix protein, IIIA3 - Capra hircus (Goat) Indicus|evm.model.CM009509.1.737 P02442 KRA3_CAPHI 90.152 0.977444 1.00758 Keratin, high-sulfur matrix protein, IIIA3 - Capra hircus (Goat) Indicus|evm.model.CM009509.1.738 P02442 KRA3_CAPHI 90.909 0.977444 1.00758 Keratin, high-sulfur matrix protein, IIIA3 - Capra hircus (Goat) Indicus|evm.model.CM009509.1.739 P18621 RL17_HUMAN 95.604 0.978261 0.5 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009509.1.740 P02442 KRA3_CAPHI 91.667 0.977444 1.00758 Keratin, high-sulfur matrix protein, IIIA3 - Capra hircus (Goat) Indicus|evm.model.CM009509.1.752 A8MUX0 KR161_HUMAN 64.522 0.621483 1.51257 KRTAP16-1 - Keratin-associated protein 16-1 - Homo sapiens (Human) - KRTAP16-1 gene cytosol, keratinization Indicus|evm.model.CM009509.1.753 P25690 K1M2_SHEEP 94.802 0.995025 0.99505 Keratin, type I microfibrillar, 47.6 kDa - Ovis aries (Sheep) Indicus|evm.model.CM009509.1.754 P02534 K1M1_SHEEP 91.176 0.519531 1.86408 Keratin, type I microfibrillar 48 kDa, component 8C-1 - Ovis aries (Sheep) Indicus|evm.model.CM009509.1.755 P02534 K1M1_SHEEP 97.349 0.992806 1.01214 Keratin, type I microfibrillar 48 kDa, component 8C-1 - Ovis aries (Sheep) Indicus|evm.model.CM009509.1.756 O76015 KRT38_HUMAN 77.953 0.957179 0.870614 KRT38 - Keratin, type I cuticular Ha8 - Homo sapiens (Human) - KRT38 gene cytosol, extracellular exosome, structural molecule activity, cornification, keratinization Indicus|evm.model.CM009509.1.757 O76015 KRT38_HUMAN 80.387 0.983651 0.804825 KRT38 - Keratin, type I cuticular Ha8 - Homo sapiens (Human) - KRT38 gene cytosol, extracellular exosome, structural molecule activity, cornification, keratinization Indicus|evm.model.CM009509.1.758 B0LKP1 KRT35_SHEEP 91.892 0.561224 1.72308 KRT35 - Keratin, type I cuticular Ha5 - Ovis aries (Sheep) - KRT35 gene Indicus|evm.model.CM009509.1.759 O76013 KRT36_HUMAN 84.665 0.991247 0.978587 KRT36 - Keratin, type I cuticular Ha6 - Homo sapiens (Human) - KRT36 gene cytosol, extracellular exosome, structural constituent of skin epidermis, cornification, keratinization Indicus|evm.model.CM009509.1.760 P13646 K1C13_HUMAN 89.227 0.970115 0.949782 KRT13 - Keratin, type I cytoskeletal 13 - Homo sapiens (Human) - KRT13 gene cytosol, extracellular exosome, intermediate filament cytoskeleton, keratin filament, nucleus, cornification, cytoskeleton organization, keratinization Indicus|evm.model.CM009509.1.761 O77727 K1C15_SHEEP 96.542 0.994253 0.768212 KRT15 - Keratin, type I cytoskeletal 15 - Ovis aries (Sheep) - KRT15 gene Indicus|evm.model.CM009509.1.762 P08728 K1C19_BOVIN 100.000 0.995 1.00251 KRT19 - Keratin, type I cytoskeletal 19 - Bos taurus (Bovine) - KRT19 gene Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity). Indicus|evm.model.CM009509.1.763 O18740 K1C9_CANLF 75.076 0.620038 0.673028 KRT9 - Keratin, type I cytoskeletal 9 - Canis lupus familiaris (Dog) - KRT9 gene May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly (By similarity). Indicus|evm.model.CM009509.1.764 P02533 K1C14_HUMAN 95.845 0.751046 1.01271 KRT14 - Keratin, type I cytoskeletal 14 - Homo sapiens (Human) - KRT14 gene The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. Indicus|evm.model.CM009509.1.765 P08779 K1C16_HUMAN 77.231 0.732227 0.892178 KRT16 - Keratin, type I cytoskeletal 16 - Homo sapiens (Human) - KRT16 gene Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. Indicus|evm.model.CM009509.1.766 A1L595 K1C17_BOVIN 99.546 0.995475 1.00227 KRT17 - Keratin, type I cytoskeletal 17 - Bos taurus (Bovine) - KRT17 gene Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Indicus|evm.model.CM009509.1.767 Q6IFX2 K1C42_MOUSE 91.574 0.991189 1.00442 Krt42 - Keratin, type I cytoskeletal 42 - Mus musculus (Mouse) - Krt42 gene Indicus|evm.model.CM009509.1.768 Q5RFF4 EIF1_PONAB 100.000 0.982456 1.00885 EIF1 - Eukaryotic translation initiation factor 1 - Pongo abelii (Sumatran orangutan) - EIF1 gene Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (By similarity). Indicus|evm.model.CM009509.1.769 P04564 GAST_CAPHI 100.000 0.314286 3.08824 GAST - Gastrin precursor - Capra hircus (Goat) - GAST gene Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Indicus|evm.model.CM009509.1.770 P54257 HAP1_HUMAN 62.500 0.988372 0.897168 HAP1 - Huntingtin-associated protein 1 - Homo sapiens (Human) - HAP1 gene Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17). Indicus|evm.model.CM009509.1.771 Q8SPJ1 PLAK_BOVIN 100.000 0.939394 1.06309 JUP - Junction plakoglobin - Bos taurus (Bovine) - JUP gene Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). Indicus|evm.model.CM009509.1.772 Q2HJ89 FKB10_BOVIN 100.000 0.208226 0.667238 FKBP10 - Peptidyl-prolyl cis-trans isomerase FKBP10 precursor - Bos taurus (Bovine) - FKBP10 gene PPIases accelerate the folding of proteins during protein synthesis. Indicus|evm.model.CM009509.1.773 Q2HJ89 FKB10_BOVIN 99.800 0.968992 0.885077 FKBP10 - Peptidyl-prolyl cis-trans isomerase FKBP10 precursor - Bos taurus (Bovine) - FKBP10 gene PPIases accelerate the folding of proteins during protein synthesis. Indicus|evm.model.CM009509.1.774 Q969T7 5NT3B_HUMAN 90.301 0.990033 1.00333 NT5C3B - 7-methylguanosine phosphate-specific 5'-nucleotidase - Homo sapiens (Human) - NT5C3B gene Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233). Indicus|evm.model.CM009509.1.775 Q6JEL3 KLH10_RAT 99.671 0.996716 1.00164 Klhl10 - Kelch-like protein 10 - Rattus norvegicus (Rat) - Klhl10 gene May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. Indicus|evm.model.CM009509.1.776 Q9NVR0 KLH11_HUMAN 99.153 0.997179 1.00141 KLHL11 - Kelch-like protein 11 precursor - Homo sapiens (Human) - KLHL11 gene Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. Indicus|evm.model.CM009509.1.777 Q2TCH3 ACLY_SHEEP 99.364 0.998185 1.00091 ACLY - ATP-citrate synthase - Ovis aries (Sheep) - ACLY gene Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. Indicus|evm.model.CM009509.1.778 Q96NG3 ODAD4_HUMAN 78.987 0.975146 1.01786 ODAD4 - Outer dynein arm-docking complex subunit 4 - Homo sapiens (Human) - ODAD4 gene Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Plays an essential role for the assembly of ODA-DC and for the docking of ODA in ciliary axoneme. Indicus|evm.model.CM009509.1.779 P06623 CN37_BOVIN 100.000 0.947743 1.0525 CNP - 2',3'-cyclic-nucleotide 3'-phosphodiesterase precursor - Bos taurus (Bovine) - CNP gene May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Indicus|evm.model.CM009509.1.780 Q99615 DNJC7_HUMAN 80.868 0.996008 1.01417 DNAJC7 - DnaJ homolog subfamily C member 7 - Homo sapiens (Human) - DNAJC7 gene Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). Indicus|evm.model.CM009509.1.781 Q9NYR9 KBRS2_HUMAN 100.000 0.989583 1.00524 NKIRAS2 - NF-kappa-B inhibitor-interacting Ras-like protein 2 - Homo sapiens (Human) - NKIRAS2 gene Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). Indicus|evm.model.CM009509.1.782 Q66K41 Z385C_HUMAN 89.021 0.947846 1.04502 ZNF385C - Zinc finger protein 385C - Homo sapiens (Human) - ZNF385C gene nucleus Indicus|evm.model.CM009509.1.783 A0A1B0GUU1 CQ113_HUMAN 89.926 0.997041 1.00148 C17orf113 - Transmembrane protein C17orf113 - Homo sapiens (Human) - C17orf113 gene Indicus|evm.model.CM009509.1.784 Q6PBT9 Z385B_DANRE 59.524 0.369369 0.22561 znf385b - Zinc finger protein 385B - Danio rerio (Zebrafish) - znf385b gene May play a role in p53/TP53-mediated apoptosis. Indicus|evm.model.CM009509.1.785 Q96C10 DHX58_HUMAN 83.407 0.997063 1.00442 DHX58 - Probable ATP-dependent RNA helicase DHX58 - Homo sapiens (Human) - DHX58 gene Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes (PubMed:31256877). Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. Indicus|evm.model.CM009509.1.786 Q9JHD2 KAT2A_MOUSE 99.737 0.437644 1.04337 Kat2a - Histone acetyltransferase KAT2A - Mus musculus (Mouse) - Kat2a gene Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:28424240). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (By similarity). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (By similarity). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:28424240). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (By similarity). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (PubMed:25024434). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (PubMed:28424240). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (PubMed:30424580). Regulates embryonic stem cell (ESC) pluripotency and differentiation (PubMed:30270482). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (By similarity). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (By similarity). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (By similarity). Indicus|evm.model.CM009509.1.787 Q2TBQ6 HSPB9_BOVIN 100.000 0.987342 1.00637 HSPB9 - Heat shock protein beta-9 - Bos taurus (Bovine) - HSPB9 gene cytoplasm, nucleus Indicus|evm.model.CM009509.1.788 Q58DS9 RAB5C_BOVIN 100.000 0.990783 1.00463 RAB5C - Ras-related protein Rab-5C - Bos taurus (Bovine) - RAB5C gene Protein transport. Probably involved in vesicular traffic. Indicus|evm.model.CM009509.1.789 Q9R1T9 KCNH4_RAT 93.582 0.94772 0.883972 Kcnh4 - Potassium voltage-gated channel subfamily H member 4 - Rattus norvegicus (Rat) - Kcnh4 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly. Indicus|evm.model.CM009509.1.790 P56717 OREX_BOVIN 100.000 0.242424 4 HCRT - Orexin-A - Bos taurus (Bovine) - HCRT gene Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity). Indicus|evm.model.CM009509.1.791 Q8N2G8 GHDC_HUMAN 83.465 0.956604 1 GHDC - GH3 domain-containing protein precursor - Homo sapiens (Human) - GHDC gene cytoplasm, extracellular region, membrane, secretory granule lumen, specific granule lumen, acid-amino acid ligase activity, neutrophil degranulation Indicus|evm.model.CM009509.1.792 Q9TUM3 STA5B_BOVIN 99.619 0.997462 1.00127 STAT5B - Signal transducer and activator of transcription 5B - Bos taurus (Bovine) - STAT5B gene Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. Indicus|evm.model.CM009509.1.793 Q95115 STA5A_BOVIN 97.619 0.997472 0.996222 STAT5A - Signal transducer and activator of transcription 5A - Bos taurus (Bovine) - STAT5A gene Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). Indicus|evm.model.CM009509.1.794 P40763 STAT3_HUMAN 99.740 0.997406 1.0013 STAT3 - Signal transducer and activator of transcription 3 - Homo sapiens (Human) - STAT3 gene Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Indicus|evm.model.CM009509.1.795 Q6NZI2 CAVN1_HUMAN 93.077 0.994885 1.00256 CAVIN1 - Caveolae-associated protein 1 - Homo sapiens (Human) - CAVIN1 gene Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). Indicus|evm.model.CM009509.1.796 Q5E9I1 CCNG1_BOVIN 97.398 0.943662 0.962712 CCNG1 - Cyclin-G1 - Bos taurus (Bovine) - CCNG1 gene May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). Indicus|evm.model.CM009509.1.797 Q29466 VPP1_BOVIN 98.343 0.997619 1.00239 ATP6V0A1 - V-type proton ATPase 116 kDa subunit a1 - Bos taurus (Bovine) - ATP6V0A1 gene Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). Indicus|evm.model.CM009509.1.798 P54802 ANAG_HUMAN 86.591 0.943396 0.998654 NAGLU - Alpha-N-acetylglucosaminidase precursor - Homo sapiens (Human) - NAGLU gene Involved in the degradation of heparan sulfate. Indicus|evm.model.CM009509.1.799 P14061 DHB1_HUMAN 73.540 0.91195 0.969512 HSD17B1 - 17-beta-hydroxysteroid dehydrogenase type 1 - Homo sapiens (Human) - HSD17B1 gene Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH. Indicus|evm.model.CM009509.1.801 Q8MIR4 COASY_PIG 93.772 0.996448 1.00178 COASY - Bifunctional coenzyme A synthase - Sus scrofa (Pig) - COASY gene Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. Indicus|evm.model.CM009509.1.802 Q9UH92 MLX_HUMAN 95.302 0.993311 1.00336 MLX - Max-like protein X - Homo sapiens (Human) - MLX gene Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. Indicus|evm.model.CM009509.1.803 Q9P2W1 HOP2_HUMAN 91.244 0.990826 1.00461 PSMC3IP - Homologous-pairing protein 2 homolog - Homo sapiens (Human) - PSMC3IP gene Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. Indicus|evm.model.CM009509.1.804 Q86VR2 RETR3_HUMAN 93.562 0.995717 1.00215 RETREG3 - Reticulophagy regulator 3 - Homo sapiens (Human) - RETREG3 gene Mediates NRF1-enhanced neurite outgrowth. Indicus|evm.model.CM009509.1.805 Q0VCD2 TBG1_BOVIN 100.000 0.995575 1.00222 TUBG1 - Tubulin gamma-1 chain - Bos taurus (Bovine) - TUBG1 gene Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity). Indicus|evm.model.CM009509.1.806 Q32KM1 TBG2_BOVIN 100.000 0.995575 1.00222 TUBG2 - Tubulin gamma-2 chain - Bos taurus (Bovine) - TUBG2 gene Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity). Indicus|evm.model.CM009509.1.807 Q7Z736 PKHH3_HUMAN 95.825 0.663304 1 PLEKHH3 - Pleckstrin homology domain-containing family H member 3 precursor - Homo sapiens (Human) - PLEKHH3 gene extracellular space Indicus|evm.model.CM009509.1.808 P46092 CCR10_HUMAN 91.530 0.994536 1.01105 CCR10 - C-C chemokine receptor type 10 - Homo sapiens (Human) - CCR10 gene Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. Indicus|evm.model.CM009509.1.809 P78357 CNTP1_HUMAN 95.821 0.99856 1.00361 CNTNAP1 - Contactin-associated protein 1 precursor - Homo sapiens (Human) - CNTNAP1 gene Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. Indicus|evm.model.CM009509.1.810 A7E2Z2 EZH1_BOVIN 100.000 0.967575 1.03213 EZH1 - Histone-lysine N-methyltransferase EZH1 - Bos taurus (Bovine) - EZH1 gene Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Indicus|evm.model.CM009509.1.811 Q5E9A6 VPS25_BOVIN 100.000 0.519288 1.91477 VPS25 - Vacuolar protein-sorting-associated protein 25 - Bos taurus (Bovine) - VPS25 gene Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL (By similarity). Indicus|evm.model.CM009509.1.812 Q96J92 WNK4_HUMAN 87.862 0.998381 0.993564 WNK4 - Serine/threonine-protein kinase WNK4 - Homo sapiens (Human) - WNK4 gene Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity). Indicus|evm.model.CM009509.1.813 Q3T0E3 COA3_BOVIN 100.000 0.981308 1.00943 COA3 - Cytochrome c oxidase assembly factor 3 homolog, mitochondrial - Bos taurus (Bovine) - COA3 gene Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. Indicus|evm.model.CM009509.1.814 Q9D995 CNTD1_MOUSE 89.172 0.923077 1.01198 Cntd1 - Cyclin N-terminal domain-containing protein 1 - Mus musculus (Mouse) - Cntd1 gene site of double-strand break, reciprocal meiotic recombination, spermatogenesis Indicus|evm.model.CM009509.1.815 Q4A1L4 BECN1_BOVIN 100.000 0.833955 1.19643 BECN1 - Beclin-1 - Bos taurus (Bovine) - BECN1 gene Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity). Indicus|evm.model.CM009509.1.816 P61291 PSME3_PIG 100.000 0.992157 1.00394 PSME3 - Proteasome activator complex subunit 3 - Sus scrofa (Pig) - PSME3 gene Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity). Indicus|evm.model.CM009509.1.817 O75106 AOC2_HUMAN 88.594 0.994716 1.00132 AOC2 - Retina-specific copper amine oxidase precursor - Homo sapiens (Human) - AOC2 gene Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina. Indicus|evm.model.CM009509.1.818 Q9TTK6 AOC3_BOVIN 99.607 0.997382 1.00131 AOC3 - Membrane primary amine oxidase - Bos taurus (Bovine) - AOC3 gene Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity (By similarity). Indicus|evm.model.CM009509.1.819 Q16853 AOC3_HUMAN 88.785 0.0983302 1.41284 AOC3 - Membrane primary amine oxidase - Homo sapiens (Human) - AOC3 gene Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. Indicus|evm.model.CM009509.1.820 Q29437 AOCX_BOVIN 99.584 0.921995 1.02625 Primary amine oxidase, liver isozyme precursor - Bos taurus (Bovine) Indicus|evm.model.CM009509.1.821 O46406 AOCY_BOVIN 89.723 0.961929 1.03412 Primary amine oxidase, lung isozyme precursor - Bos taurus (Bovine) Indicus|evm.model.CM009509.1.822 Q29RU6 G6PC1_BOVIN 99.160 0.994413 1.0028 G6PC1 - Glucose-6-phosphatase catalytic subunit 1 - Bos taurus (Bovine) - G6PC1 gene Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Indicus|evm.model.CM009509.1.823 Q32LK1 AASD1_BOVIN 92.130 0.733456 1.22523 AARSD1 - Alanyl-tRNA editing protein Aarsd1 - Bos taurus (Bovine) - AARSD1 gene Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). Indicus|evm.model.CM009509.1.824 Q96C34 RUND1_HUMAN 93.023 0.978827 1.00163 RUNDC1 - RUN domain-containing protein 1 - Homo sapiens (Human) - RUNDC1 gene May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. Indicus|evm.model.CM009509.1.825 P61354 RL27_RAT 100.000 0.985401 1.00735 Rpl27 - 60S ribosomal protein L27 - Rattus norvegicus (Rat) - Rpl27 gene Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity). Indicus|evm.model.CM009509.1.826 P80217 IN35_HUMAN 72.982 0.933555 1.05245 IFI35 - Interferon-induced 35 kDa protein - Homo sapiens (Human) - IFI35 gene Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines (PubMed:29038465). Indicus|evm.model.CM009509.1.827 Q62465 VAT1_MOUSE 90.691 0.930521 0.992611 Vat1 - Synaptic vesicle membrane protein VAT-1 homolog - Mus musculus (Mouse) - Vat1 gene Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity). Indicus|evm.model.CM009509.1.828 P52198 RND2_HUMAN 95.477 0.933962 0.933921 RND2 - Rho-related GTP-binding protein RhoN precursor - Homo sapiens (Human) - RND2 gene May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity). Indicus|evm.model.CM009509.1.829 Q864U1 BRCA1_BOVIN 99.676 0.99892 1.00108 BRCA1 - Breast cancer type 1 susceptibility protein homolog - Bos taurus (Bovine) - BRCA1 gene E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator. Indicus|evm.model.CM009509.1.830 Q5RC94 NBR1_PONAB 88.235 0.291793 1.10403 NBR1 - Next to BRCA1 gene 1 protein - Pongo abelii (Sumatran orangutan) - NBR1 gene Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. Indicus|evm.model.CM009509.1.831 Q5EA90 T106A_BOVIN 100.000 0.992366 1.00383 TMEM106A - Transmembrane protein 106A - Bos taurus (Bovine) - TMEM106A gene Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (By similarity). Indicus|evm.model.CM009509.1.832 P62305 RUXE_MOUSE 94.565 0.978495 1.01087 Snrpe - Small nuclear ribonucleoprotein E - Mus musculus (Mouse) - Snrpe gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. Indicus|evm.model.CM009509.1.833 Q0VC18 ARL4D_BOVIN 100.000 0.99005 1.005 ARL4D - ADP-ribosylation factor-like protein 4D - Bos taurus (Bovine) - ARL4D gene Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity). Indicus|evm.model.CM009509.1.834 Q14562 DHX8_HUMAN 98.525 0.998362 1.00082 DHX8 - ATP-dependent RNA helicase DHX8 - Homo sapiens (Human) - DHX8 gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). Indicus|evm.model.CM009509.1.835 P43268 ETV4_HUMAN 95.258 0.995885 1.00413 ETV4 - ETS translocation variant 4 - Homo sapiens (Human) - ETV4 gene Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). Indicus|evm.model.CM009509.1.836 A2T7T2 MEOX1_PONPY 89.764 0.992157 1.00394 MEOX1 - Homeobox protein MOX-1 - Pongo pygmaeus (Bornean orangutan) - MEOX1 gene Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Indicus|evm.model.CM009509.1.837 Q9BG79 SOST_BOVIN 99.528 0.99061 1.00472 SOST - Sclerostin precursor - Bos taurus (Bovine) - SOST gene Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. Indicus|evm.model.CM009509.1.838 Q5RD73 DUS3_PONAB 98.370 0.983871 1.00541 DUSP3 - Dual specificity protein phosphatase 3 - Pongo abelii (Sumatran orangutan) - DUSP3 gene Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity). Indicus|evm.model.CM009509.1.839 B2RV13 CF97D_HUMAN 90.244 0.987879 1.0061 CFAP97D1 - Sperm axonemal maintenance protein CFAP97D1 - Homo sapiens (Human) - CFAP97D1 gene Required for male fertility through its role in axonemal doublet stabilization which is essential for sperm motility and fertilization. Indicus|evm.model.CM009509.1.840 Q13368 MPP3_HUMAN 93.333 0.996587 1.00171 MPP3 - MAGUK p55 subfamily member 3 - Homo sapiens (Human) - MPP3 gene Indicus|evm.model.CM009509.1.841 A5D7B2 CLM9_BOVIN 94.510 0.991803 0.956863 CD300LG - CMRF35-like molecule 9 precursor - Bos taurus (Bovine) - CD300LG gene Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity). Indicus|evm.model.CM009509.1.842 D3ZAA9 MPP2_RAT 98.188 0.909241 1.09783 Mpp2 - MAGUK p55 subfamily member 2 - Rattus norvegicus (Rat) - Mpp2 gene Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (PubMed:27756895). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (By similarity). Indicus|evm.model.CM009509.1.843 P01302 PAHO_BOVIN 100.000 0.90625 0.732824 PPY - Pancreatic prohormone precursor - Bos taurus (Bovine) - PPY gene Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. Indicus|evm.model.CM009509.1.844 P51694 PYY_BOVIN 100.000 0.977273 0.907216 PYY - Peptide YY precursor - Bos taurus (Bovine) - PYY gene This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. Indicus|evm.model.CM009509.1.845 P06833 PYY2_BOVIN 90.476 0.632653 1.225 PYY2 - Caltrin precursor - Bos taurus (Bovine) - PYY2 gene Inhibits calcium transport into spermatozoa; it does not bind directly to calcium. Binds to calmodulin. Inhibits the growth of microorganisms. Seem to act as an antibiotic by permeabilizing the bacterial membrane. Indicus|evm.model.CM009509.1.846 Q8N159 NAGS_HUMAN 88.889 0.940187 1.00187 NAGS - N-acetylglutamate synthase, mitochondrial precursor - Homo sapiens (Human) - NAGS gene Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. Indicus|evm.model.CM009509.1.847 Q2KIB3 TM101_BOVIN 100.000 0.992248 1.00389 TMEM101 - Transmembrane protein 101 - Bos taurus (Bovine) - TMEM101 gene May activate NF-kappa-B signaling pathways. Indicus|evm.model.CM009509.1.848 Q5RAT5 LSM12_PONAB 100.000 0.989796 1.00513 LSM12 - Protein LSM12 homolog - Pongo abelii (Sumatran orangutan) - LSM12 gene Indicus|evm.model.CM009509.1.849 Q148G2 G6PC3_BOVIN 100.000 0.994236 1.00289 G6PC3 - Glucose-6-phosphatase 3 - Bos taurus (Bovine) - G6PC3 gene Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function (By similarity). Indicus|evm.model.CM009509.1.850 Q80ZH1 HDAC5_CRIGR 95.613 0.998211 1.0063 HDAC5 - Histone deacetylase 5 - Cricetulus griseus (Chinese hamster) - HDAC5 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). Serves as a corepressor of RARA and causes its deacetylation (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity). Indicus|evm.model.CM009509.1.852 Q8N3J3 HROB_HUMAN 72.409 0.981679 1.01236 HROB - Homologous recombination OB-fold protein - Homo sapiens (Human) - HROB gene DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. Indicus|evm.model.CM009509.1.853 Q96NS5 ASB16_HUMAN 76.380 0.995595 1.00221 ASB16 - Ankyrin repeat and SOCS box protein 16 - Homo sapiens (Human) - ASB16 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009509.1.854 Q2HJA8 TMUB2_BOVIN 99.379 0.993808 1.00311 TMUB2 - Transmembrane and ubiquitin-like domain-containing protein 2 - Bos taurus (Bovine) - TMUB2 gene ubiquitin-dependent ERAD pathway Indicus|evm.model.CM009509.1.855 Q14CW9 AT7L3_HUMAN 99.424 0.862843 1.15562 ATXN7L3 - Ataxin-7-like protein 3 - Homo sapiens (Human) - ATXN7L3 gene Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583). Indicus|evm.model.CM009509.1.856 P17480 UBF1_HUMAN 91.433 0.87656 0.943717 UBTF - Nucleolar transcription factor 1 - Homo sapiens (Human) - UBTF gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Indicus|evm.model.CM009509.1.857 P02730 B3AT_HUMAN 76.591 0.993555 1.02195 SLC4A1 - Band 3 anion transport protein - Homo sapiens (Human) - SLC4A1 gene Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. Indicus|evm.model.CM009509.1.858 Q17QK1 RUN3A_BOVIN 100.000 0.995475 1.00227 RUNDC3A - RUN domain-containing protein 3A - Bos taurus (Bovine) - RUNDC3A gene May act as an effector of RAP2A in neuronal cells. Indicus|evm.model.CM009509.1.859 Q17QI7 S2539_BOVIN 100.000 0.994444 1.00279 SLC25A39 - Solute carrier family 25 member 39 - Bos taurus (Bovine) - SLC25A39 gene Required for normal heme biosynthesis. Indicus|evm.model.CM009509.1.860 P28799 GRN_HUMAN 76.728 0.996599 0.991568 GRN - Progranulin precursor - Homo sapiens (Human) - GRN gene Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28541286, PubMed:28073925, PubMed:18378771, PubMed:28453791, PubMed:12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771). Indicus|evm.model.CM009509.1.861 A2A699 F1712_MOUSE 97.611 0.95114 0.373479 Fam171a2 - Protein FAM171A2 precursor - Mus musculus (Mouse) - Fam171a2 gene Indicus|evm.model.CM009509.1.862 P08514 ITA2B_HUMAN 78.420 0.99705 0.978826 ITGA2B - Integrin alpha-IIb precursor - Homo sapiens (Human) - ITGA2B gene Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Indicus|evm.model.CM009509.1.863 Q9UKJ3 GPTC8_HUMAN 92.185 0.998675 1.00533 GPATCH8 - G patch domain-containing protein 8 - Homo sapiens (Human) - GPATCH8 gene nucleus, RNA binding Indicus|evm.model.CM009509.1.864 Q14332 FZD2_HUMAN 99.823 0.996466 1.00177 FZD2 - Frizzled-2 precursor - Homo sapiens (Human) - FZD2 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Indicus|evm.model.CM009509.1.865 A2AG06 MEIOC_MOUSE 90.784 0.996812 0.97513 Meioc - Meiosis-specific coiled-coil domain-containing protein MEIOC - Mus musculus (Mouse) - Meioc gene Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle (PubMed:28380054). Indicus|evm.model.CM009509.1.866 Q96MW1 CCD43_HUMAN 92.070 0.991228 1.01786 CCDC43 - Coiled-coil domain-containing protein 43 - Homo sapiens (Human) - CCDC43 gene cytosol Indicus|evm.model.CM009509.1.867 O75078 ADA11_HUMAN 95.728 0.5984 1.62549 ADAM11 - Disintegrin and metalloproteinase domain-containing protein 11 precursor - Homo sapiens (Human) - ADAM11 gene Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Indicus|evm.model.CM009509.1.868 Q2HJ66 CXG1_BOVIN 99.747 0.994962 1.00253 GJC1 - Gap junction gamma-1 protein - Bos taurus (Bovine) - GJC1 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009509.1.869 Q9P298 HIG1B_HUMAN 85.859 0.98 1.0101 HIGD1B - HIG1 domain family member 1B - Homo sapiens (Human) - HIGD1B gene mitochondrion, mitochondrial respirasome assembly Indicus|evm.model.CM009509.1.870 A4FUD3 U5S1_BOVIN 99.897 0.914313 1.09259 EFTUD2 - 116 kDa U5 small nuclear ribonucleoprotein component - Bos taurus (Bovine) - EFTUD2 gene Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). Indicus|evm.model.CM009509.1.871 Q8IW40 CC103_HUMAN 80.717 0.940678 0.975207 CCDC103 - Coiled-coil domain-containing protein 103 - Homo sapiens (Human) - CCDC103 gene Dynein-attachment factor required for cilia motility. Indicus|evm.model.CM009509.1.872 A7E3C4 F187A_BOVIN 99.525 0.995249 1 FAM187A - Ig-like V-type domain-containing protein FAM187A precursor - Bos taurus (Bovine) - FAM187A gene Indicus|evm.model.CM009509.1.873 Q28115 GFAP_BOVIN 100.000 0.995338 1.00234 GFAP - Glial fibrillary acidic protein - Bos taurus (Bovine) - GFAP gene GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Indicus|evm.model.CM009509.1.874 Q86Y91 KI18B_HUMAN 77.471 0.99537 1.01408 KIF18B - Kinesin-like protein KIF18B - Homo sapiens (Human) - KIF18B gene In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. Indicus|evm.model.CM009509.1.875 O75973 C1QRF_HUMAN 98.374 0.865724 1.0969 C1QL1 - C1q-related factor precursor - Homo sapiens (Human) - C1QL1 gene May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Indicus|evm.model.CM009509.1.876 Q3ZBS0 DCAKD_BOVIN 99.134 0.991379 1.00433 DCAKD - Dephospho-CoA kinase domain-containing protein - Bos taurus (Bovine) - DCAKD gene dephospho-CoA kinase activity, coenzyme A biosynthetic process Indicus|evm.model.CM009509.1.877 P31717 NMT1_BOVIN 92.308 0.996154 1.04628 NMT1 - Glycylpeptide N-tetradecanoyltransferase 1 - Bos taurus (Bovine) - NMT1 gene Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Indicus|evm.model.CM009509.1.878 Q8N3E9 PLCD3_HUMAN 86.918 0.957524 1.04436 PLCD3 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 - Homo sapiens (Human) - PLCD3 gene Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). Indicus|evm.model.CM009509.1.879 Q2KHT9 ACBD4_BOVIN 99.670 0.934985 1.06601 ACBD4 - Acyl-CoA-binding domain-containing protein 4 - Bos taurus (Bovine) - ACBD4 gene Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters. Indicus|evm.model.CM009509.1.880 Q0X0C4 HEXI1_BOVIN 100.000 0.993769 1.00313 HEXIM1 - Protein HEXIM1 - Bos taurus (Bovine) - HEXIM1 gene Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009509.1.881 Q0X0E2 HEXI2_BOVIN 99.653 0.99308 1.00697 HEXIM2 - Protein HEXIM2 - Bos taurus (Bovine) - HEXIM2 gene Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Indicus|evm.model.CM009509.1.882 O95466 FMNL1_HUMAN 93.962 0.461203 1.04273 FMNL1 - Formin-like protein 1 - Homo sapiens (Human) - FMNL1 gene May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Indicus|evm.model.CM009509.1.885 Q99558 M3K14_HUMAN 88.180 0.997904 1.00739 MAP3K14 - Mitogen-activated protein kinase kinase kinase 14 - Homo sapiens (Human) - MAP3K14 gene Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner. Indicus|evm.model.CM009509.1.886 A2AB59 RHG27_MOUSE 81.729 0.911278 0.765247 Arhgap27 - Rho GTPase-activating protein 27 - Mus musculus (Mouse) - Arhgap27 gene Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). Indicus|evm.model.CM009509.1.887 Q9Y4G2 PKHM1_HUMAN 81.038 0.473233 0.88447 PLEKHM1 - Pleckstrin homology domain-containing family M member 1 - Homo sapiens (Human) - PLEKHM1 gene Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). Indicus|evm.model.CM009509.1.888 Q49AS3 L37A5_HUMAN 80.822 0.0277778 24.1132 LRRC37A5P - Putative protein LRRC37A5P - Homo sapiens (Human) - LRRC37A5P gene Indicus|evm.model.CM009509.1.889 Q4R856 RDM1_MACFA 80.702 0.993007 1.00704 RDM1 - RAD52 motif-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - RDM1 gene May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA (By similarity). Indicus|evm.model.CM009509.1.890 Q29RT1 LYZL6_BOVIN 99.324 0.986577 1.00676 LYZL6 - Lysozyme-like protein 6 precursor - Bos taurus (Bovine) - LYZL6 gene May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (By similarity). Indicus|evm.model.CM009509.1.892 Q8N4K4 RPRML_HUMAN 90.083 0.983607 1.01667 RPRML - Reprimo-like protein - Homo sapiens (Human) - RPRML gene Indicus|evm.model.CM009509.1.893 O35165 GOSR2_RAT 94.340 0.99061 1.00472 Gosr2 - Golgi SNAP receptor complex member 2 - Rattus norvegicus (Rat) - Gosr2 gene Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. Indicus|evm.model.CM009509.1.894 O14905 WNT9B_HUMAN 94.328 0.930168 1.0028 WNT9B - Protein Wnt-9b precursor - Homo sapiens (Human) - WNT9B gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity). Indicus|evm.model.CM009509.1.895 P56703 WNT3_HUMAN 99.155 0.994382 1.00282 WNT3 - Proto-oncogene Wnt-3 precursor - Homo sapiens (Human) - WNT3 gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406). Indicus|evm.model.CM009509.1.896 P46459 NSF_HUMAN 99.059 0.98672 1.0121 NSF - Vesicle-fusing ATPase - Homo sapiens (Human) - NSF gene Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). Indicus|evm.model.CM009509.1.897 P84082 ARF2_RAT 100.000 0.837209 1.18785 Arf2 - ADP-ribosylation factor 2 - Rattus norvegicus (Rat) - Arf2 gene GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Indicus|evm.model.CM009509.1.898 Q76LL8 CRFR1_MACMU 90.580 0.915888 1.03133 CRHR1 - Corticotropin-releasing factor receptor 1 precursor - Macaca mulatta (Rhesus macaque) - CRHR1 gene G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. Indicus|evm.model.CM009509.1.899 Q8IUH8 SPP2C_HUMAN 73.055 0.997106 1.01023 SPPL2C - Signal peptide peptidase-like 2C precursor - Homo sapiens (Human) - SPPL2C gene Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane. Indicus|evm.model.CM009509.1.901 O02828 TAU_CAPHI 97.411 0.503289 1.50868 MAPT - Microtubule-associated protein tau - Capra hircus (Goat) - MAPT gene Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Indicus|evm.model.CM009509.1.904 Q7Z3B3 KANL1_HUMAN 94.304 0.998188 0.999095 KANSL1 - KAT8 regulatory NSL complex subunit 1 - Homo sapiens (Human) - KANSL1 gene As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. Indicus|evm.model.CM009509.1.905 A7Z061 CDC27_BOVIN 99.879 0.997576 1 CDC27 - Cell division cycle protein 27 homolog - Bos taurus (Bovine) - CDC27 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Indicus|evm.model.CM009509.1.907 P12829 MYL4_HUMAN 91.411 0.817259 1 MYL4 - Myosin light chain 4 - Homo sapiens (Human) - MYL4 gene Regulatory light chain of myosin. Does not bind calcium. Indicus|evm.model.CM009509.1.908 Q7Z417 NUFP2_HUMAN 86.902 0.994565 0.529496 NUFIP2 - Nuclear fragile X mental retardation-interacting protein 2 - Homo sapiens (Human) - NUFIP2 gene Binds RNA. Indicus|evm.model.CM009509.1.909 Q7Z417 NUFP2_HUMAN 90.391 0.992883 0.404317 NUFIP2 - Nuclear fragile X mental retardation-interacting protein 2 - Homo sapiens (Human) - NUFIP2 gene Binds RNA. Indicus|evm.model.CM009509.1.910 P05106 ITB3_HUMAN 94.889 0.559061 1.7297 ITGB3 - Integrin beta-3 precursor - Homo sapiens (Human) - ITGB3 gene Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). Indicus|evm.model.CM009509.1.911 Q99880 H2B1L_HUMAN 89.683 0.984252 1.00794 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009509.1.912 Q2T9P0 EFCB3_BOVIN 99.543 0.136435 7.31279 EFCAB3 - EF-hand calcium-binding domain-containing protein 3 - Bos taurus (Bovine) - EFCAB3 gene Indicus|evm.model.CM009509.1.913 Q0P5B2 METL2_BOVIN 99.735 0.994723 1.00265 METTL2 - tRNA N(3)-methylcytidine methyltransferase METTL2 - Bos taurus (Bovine) - METTL2 gene S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Indicus|evm.model.CM009509.1.915 Q86UE8 TLK2_HUMAN 96.632 0.939774 1.03238 TLK2 - Serine/threonine-protein kinase tousled-like 2 - Homo sapiens (Human) - TLK2 gene Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Indicus|evm.model.CM009509.1.916 Q9UBG0 MRC2_HUMAN 92.485 0.989262 1.00744 MRC2 - C-type mannose receptor 2 precursor - Homo sapiens (Human) - MRC2 gene May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). Indicus|evm.model.CM009509.1.917 Q8NA82 MARHA_HUMAN 70.581 0.975816 1.02351 MARCHF10 - Probable E3 ubiquitin-protein ligase MARCHF10 - Homo sapiens (Human) - MARCHF10 gene E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Indicus|evm.model.CM009509.1.918 Q9HCD6 TANC2_HUMAN 100.000 0.0339147 1.03719 TANC2 - Protein TANC2 - Homo sapiens (Human) - TANC2 gene Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. Indicus|evm.model.CM009509.1.919 P10897 CY561_BOVIN 100.000 0.569161 1.75 CYB561 - Transmembrane ascorbate-dependent reductase CYB561 - Bos taurus (Bovine) - CYB561 gene Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles (PubMed:3597367, PubMed:1623014, PubMed:18501187). It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes (Probable). Indicus|evm.model.CM009509.1.920 P12822 ACE_RABIT 83.170 0.986566 0.90916 ACE - Angiotensin-converting enzyme precursor - Oryctolagus cuniculus (Rabbit) - ACE gene Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity). Indicus|evm.model.CM009509.1.921 D0G895 ACE3_MOUSE 68.493 0.938224 1.05427 Ace3 - Angiotensin-converting enzyme-like protein Ace3 precursor - Mus musculus (Mouse) - Ace3 gene acrosomal vesicle, plasma membrane, metallopeptidase activity, peptidyl-dipeptidase activity, positive regulation of systemic arterial blood pressure, regulation of systemic arterial blood pressure by renin-angiotensin Indicus|evm.model.CM009509.1.922 O54853 KCNH6_RAT 97.810 0.134653 1.06316 Kcnh6 - Potassium voltage-gated channel subfamily H member 6 - Rattus norvegicus (Rat) - Kcnh6 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Indicus|evm.model.CM009509.1.923 P61963 DCAF7_MOUSE 100.000 0.994169 1.00292 Dcaf7 - DDB1- and CUL4-associated factor 7 - Mus musculus (Mouse) - Dcaf7 gene Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). Indicus|evm.model.CM009509.1.924 Q9BSH4 TACO1_HUMAN 84.099 0.946309 1.00337 TACO1 - Translational activator of cytochrome c oxidase 1 - Homo sapiens (Human) - TACO1 gene Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Indicus|evm.model.CM009509.1.925 Q99759 M3K3_HUMAN 92.530 0.893588 1.17093 MAP3K3 - Mitogen-activated protein kinase kinase kinase 3 - Homo sapiens (Human) - MAP3K3 gene Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. Indicus|evm.model.CM009509.1.926 Q1LZA7 LIMD2_BOVIN 100.000 0.984496 1.00781 LIMD2 - LIM domain-containing protein 2 - Bos taurus (Bovine) - LIMD2 gene Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. Indicus|evm.model.CM009509.1.927 Q5E9J9 STRAA_BOVIN 100.000 0.861111 1.15818 STRADA - STE20-related kinase adapter protein alpha - Bos taurus (Bovine) - STRADA gene Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). Indicus|evm.model.CM009509.1.928 P0C204 CCD47_MACFA 97.414 0.737179 0.322981 CCDC47 - PAT complex subunit CCDC47 precursor - Macaca fascicularis (Crab-eating macaque) - CCDC47 gene Component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity). Has an essential role in the maintenance of ER organization during embryogenesis (By similarity). Indicus|evm.model.CM009509.1.929 Q3ZC50 CCD47_BOVIN 100.000 0.988506 0.720497 CCDC47 - PAT complex subunit CCDC47 precursor - Bos taurus (Bovine) - CCDC47 gene Component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity). Has an essential role in the maintenance of ER organization during embryogenesis (By similarity). Indicus|evm.model.CM009509.1.930 Q86XP3 DDX42_HUMAN 95.058 0.959432 1.05117 DDX42 - ATP-dependent RNA helicase DDX42 - Homo sapiens (Human) - DDX42 gene ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. Indicus|evm.model.CM009509.1.931 Q9DBE9 SPB1_MOUSE 85.680 0.982143 1.00239 Ftsj3 - pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 - Mus musculus (Mouse) - Ftsj3 gene RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Indicus|evm.model.CM009509.1.932 P62198 PRS8_RAT 100.000 0.995086 1.00246 Psmc5 - 26S proteasome regulatory subunit 8 - Rattus norvegicus (Rat) - Psmc5 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Indicus|evm.model.CM009509.1.933 E1BJD1 SMRD2_BOVIN 100.000 0.996241 1.00188 SMARCD2 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 - Bos taurus (Bovine) - SMARCD2 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation. Indicus|evm.model.CM009509.1.935 P01246 SOMA_BOVIN 99.539 0.881633 1.12903 GH1 - Somatotropin precursor - Bos taurus (Bovine) - GH1 gene Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Indicus|evm.model.CM009509.1.936 P40259 CD79B_HUMAN 69.264 0.991342 1.00873 CD79B - B-cell antigen receptor complex-associated protein beta chain precursor - Homo sapiens (Human) - CD79B gene Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Indicus|evm.model.CM009509.1.937 P35499 SCN4A_HUMAN 90.620 0.998937 1.02451 SCN4A - Sodium channel protein type 4 subunit alpha - Homo sapiens (Human) - SCN4A gene Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states (PubMed:12766226, PubMed:29992740, PubMed:30190309, PubMed:15318338, PubMed:16890191, PubMed:18690054, PubMed:17898326, PubMed:19347921, PubMed:25707578, PubMed:26700687). Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels (PubMed:12766226, PubMed:15318338, PubMed:16890191, PubMed:19347921, PubMed:25707578, PubMed:26700687, PubMed:26659129). Indicus|evm.model.CM009509.1.938 Q5NKV1 ICAM2_GORGO 52.245 0.300874 2.91273 ICAM2 - Intercellular adhesion molecule 2 precursor - Gorilla gorilla gorilla (Western lowland gorilla) - ICAM2 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). Indicus|evm.model.CM009509.1.939 Q5NKV1 ICAM2_GORGO 49.160 0.979253 0.876364 ICAM2 - Intercellular adhesion molecule 2 precursor - Gorilla gorilla gorilla (Western lowland gorilla) - ICAM2 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). Indicus|evm.model.CM009509.1.940 O75460 ERN1_HUMAN 94.259 0.977459 0.998976 ERN1 - Serine/threonine-protein kinase/endoribonuclease IRE1 precursor - Homo sapiens (Human) - ERN1 gene Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875, PubMed:28128204). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). Indicus|evm.model.CM009509.1.941 Q8IWB9 TEX2_HUMAN 88.952 0.996226 0.94055 TEX2 - Testis-expressed protein 2 - Homo sapiens (Human) - TEX2 gene During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. Indicus|evm.model.CM009509.1.942 Q8IWB9 TEX2_HUMAN 94.937 0.886364 0.0780834 TEX2 - Testis-expressed protein 2 - Homo sapiens (Human) - TEX2 gene During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. Indicus|evm.model.CM009509.1.943 P51866 PECA1_BOVIN 98.784 0.997294 1 PECAM1 - Platelet endothelial cell adhesion molecule precursor - Bos taurus (Bovine) - PECAM1 gene Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-689 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis. Indicus|evm.model.CM009509.1.944 Q7Z6M3 MILR1_HUMAN 63.063 0.973607 0.994169 MILR1 - Allergin-1 precursor - Homo sapiens (Human) - MILR1 gene Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity). Indicus|evm.model.CM009509.1.945 Q0VC30 DPOG2_BOVIN 100.000 0.995885 1.00206 POLG2 - DNA polymerase subunit gamma-2, mitochondrial precursor - Bos taurus (Bovine) - POLG2 gene Mitochondrial polymerase processivity subunit. It regulates the polymerase and exonuclease activities promoting processive DNA synthesis. Binds to ss-DNA. Indicus|evm.model.CM009509.1.946 P17844 DDX5_HUMAN 100.000 0.996748 1.00163 DDX5 - Probable ATP-dependent RNA helicase DDX5 - Homo sapiens (Human) - DDX5 gene Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Indicus|evm.model.CM009509.1.947 Q96GE4 CEP95_HUMAN 82.614 0.894118 1.03532 CEP95 - Centrosomal protein of 95 kDa - Homo sapiens (Human) - CEP95 gene centrosome, spindle pole Indicus|evm.model.CM009509.1.948 Q9HAU4 SMUF2_HUMAN 99.442 0.993056 0.962567 SMURF2 - E3 ubiquitin-protein ligase SMURF2 - Homo sapiens (Human) - SMURF2 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11016919). Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling (PubMed:11163210, PubMed:12717440). In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1 (PubMed:18448069). Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation (PubMed:11016919, PubMed:11158580, PubMed:11389444). SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation (PubMed:11389444). Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation (PubMed:30696809). Indicus|evm.model.CM009509.1.949 P52292 IMA1_HUMAN 95.274 0.996226 1.00189 KPNA2 - Importin subunit alpha-1 - Homo sapiens (Human) - KPNA2 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Indicus|evm.model.CM009509.1.950 Q2M2W7 CQ058_HUMAN 93.814 0.690647 1.43299 C17orf58 - UPF0450 protein C17orf58 - Homo sapiens (Human) - C17orf58 gene collagen-containing extracellular matrix Indicus|evm.model.CM009509.1.951 Q12830 BPTF_HUMAN 89.148 0.832493 0.911359 BPTF - Nucleosome-remodeling factor subunit BPTF - Homo sapiens (Human) - BPTF gene Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. Indicus|evm.model.CM009509.1.952 Q3MHH2 NOL11_BOVIN 99.582 0.997218 1.00139 NOL11 - Nucleolar protein 11 - Bos taurus (Bovine) - NOL11 gene Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b (By similarity). Indicus|evm.model.CM009509.1.953 Q9UKF7 PITC1_HUMAN 97.785 0.990566 0.957831 PITPNC1 - Cytoplasmic phosphatidylinositol transfer protein 1 - Homo sapiens (Human) - PITPNC1 gene Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). Indicus|evm.model.CM009509.1.954 Q9Y6H1 CHCH2_HUMAN 86.928 0.95 1.0596 CHCHD2 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 - Homo sapiens (Human) - CHCHD2 gene Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). Indicus|evm.model.CM009509.1.955 Q2KJ25 PSD12_BOVIN 100.000 0.995624 1.00219 PSMD12 - 26S proteasome non-ATPase regulatory subunit 12 - Bos taurus (Bovine) - PSMD12 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Indicus|evm.model.CM009509.1.957 Q641Q3 METRL_HUMAN 82.745 0.930403 0.877814 METRNL - Meteorin-like protein precursor - Homo sapiens (Human) - METRNL gene Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity). Indicus|evm.model.CM009509.1.958 Q6GV29 B3GNL_RAT 82.432 0.321586 0.635854 B3gntl1 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 - Rattus norvegicus (Rat) - B3gntl1 gene Putative glycosyltransferase. Indicus|evm.model.CM009509.1.959 Q67FW5 B3GNL_HUMAN 89.712 0.991803 0.6759 B3GNTL1 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 - Homo sapiens (Human) - B3GNTL1 gene Putative glycosyltransferase. Indicus|evm.model.CM009509.1.962 Q9H479 FN3K_HUMAN 90.939 0.993548 1.00324 FN3K - Fructosamine-3-kinase - Homo sapiens (Human) - FN3K gene Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848). Indicus|evm.model.CM009509.1.963 Q8K274 KT3K_MOUSE 87.948 0.987097 1.00324 Fn3krp - Ketosamine-3-kinase - Mus musculus (Mouse) - Fn3krp gene Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively (PubMed:14633848). Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:14633848). Not able to phosphorylate fructoselysine (PubMed:14633848). Indicus|evm.model.CM009509.1.964 Q12829 RB40B_HUMAN 89.568 0.992832 1.0036 RAB40B - Ras-related protein Rab-40B - Homo sapiens (Human) - RAB40B gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009509.1.965 Q8MIK9 PP14B_PIG 88.889 0.507772 1.31293 PPP1R14B - Protein phosphatase 1 regulatory subunit 14B - Sus scrofa (Pig) - PPP1R14B gene Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). Indicus|evm.model.CM009509.1.966 Q5MNZ6 WIPI3_HUMAN 99.128 0.994203 1.00291 WDR45B - WD repeat domain phosphoinositide-interacting protein 3 - Homo sapiens (Human) - WDR45B gene Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735). Indicus|evm.model.CM009509.1.967 Q3UCQ1 FOXK2_MOUSE 83.779 0.969325 0.751152 Foxk2 - Forkhead box protein K2 - Mus musculus (Mouse) - Foxk2 gene Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (PubMed:25402684, PubMed:29861159, PubMed:30700909). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:25402684, PubMed:29861159, PubMed:30700909). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (PubMed:30700909). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (PubMed:30700909). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (PubMed:30700909). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (PubMed:25402684). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (By similarity). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (By similarity). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (By similarity). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (By similarity). Indicus|evm.model.CM009509.1.968 Q3T114 RIDA_BOVIN 95.620 0.985507 1.0073 RIDA - 2-iminobutanoate/2-iminopropanoate deaminase - Bos taurus (Bovine) - RIDA gene Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. Indicus|evm.model.CM009509.1.969 Q9UHQ1 NARF_HUMAN 83.772 0.995624 1.00219 NARF - Nuclear prelamin A recognition factor - Homo sapiens (Human) - NARF gene lamin filament, nuclear lamina, nuclear lumen, nucleolus, nucleoplasm, lamin binding Indicus|evm.model.CM009509.1.970 Q3SZM3 CYBC1_BOVIN 100.000 0.989362 1.00535 CYBC1 - Cytochrome b-245 chaperone 1 - Bos taurus (Bovine) - CYBC1 gene Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (By similarity). Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity). Indicus|evm.model.CM009509.1.971 A6QNR0 HEXD_BOVIN 100.000 0.716667 1.38728 HEXD - Hexosaminidase D - Bos taurus (Bovine) - HEXD gene Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates. Indicus|evm.model.CM009509.1.972 Q6PK18 OGFD3_HUMAN 83.648 0.990506 0.990596 OGFOD3 - 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 - Homo sapiens (Human) - OGFOD3 gene membrane Indicus|evm.model.CM009509.1.973 P49220 UR2R_BOVIN 99.740 0.994805 1.0026 UTS2R - Urotensin-2 receptor - Bos taurus (Bovine) - UTS2R gene High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity). Indicus|evm.model.CM009509.1.974 Q8NA77 TEX19_HUMAN 65.625 0.451705 2.14634 TEX19 - Testis-expressed protein 19 - Homo sapiens (Human) - TEX19 gene Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172). Indicus|evm.model.CM009509.1.976 Q8NA77 TEX19_HUMAN 70.552 0.460227 2.14634 TEX19 - Testis-expressed protein 19 - Homo sapiens (Human) - TEX19 gene Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172). Indicus|evm.model.CM009509.1.977 Q8WVN6 SCTM1_HUMAN 45.455 0.492462 0.802419 SECTM1 - Secreted and transmembrane protein 1 precursor - Homo sapiens (Human) - SECTM1 gene May be involved in thymocyte signaling. Indicus|evm.model.CM009509.1.982 Q8WVN6 SCTM1_HUMAN 55.556 0.319277 0.669355 SECTM1 - Secreted and transmembrane protein 1 precursor - Homo sapiens (Human) - SECTM1 gene May be involved in thymocyte signaling. Indicus|evm.model.CM009509.1.983 Q8WVN6 SCTM1_HUMAN 52.101 0.797297 0.596774 SECTM1 - Secreted and transmembrane protein 1 precursor - Homo sapiens (Human) - SECTM1 gene May be involved in thymocyte signaling. Indicus|evm.model.CM009509.1.984 Q8WVN6 SCTM1_HUMAN 51.163 0.514286 0.987903 SECTM1 - Secreted and transmembrane protein 1 precursor - Homo sapiens (Human) - SECTM1 gene May be involved in thymocyte signaling. Indicus|evm.model.CM009509.1.985 P50283 CD7_MOUSE 54.787 0.916256 0.966667 Cd7 - T-cell antigen CD7 precursor - Mus musculus (Mouse) - Cd7 gene Not yet known. Indicus|evm.model.CM009509.1.987 P48730 KC1D_HUMAN 97.816 0.958042 1.03373 CSNK1D - Casein kinase I isoform delta - Homo sapiens (Human) - CSNK1D gene Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. Indicus|evm.model.CM009509.1.988 O35910 MOT4_RAT 89.384 0.934959 1.04459 Slc16a3 - Monocarboxylate transporter 4 - Rattus norvegicus (Rat) - Slc16a3 gene Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). Indicus|evm.model.CM009509.1.989 Q2TAC2 CCD57_HUMAN 68.449 0.712329 1.11694 CCDC57 - Coiled-coil domain-containing protein 57 - Homo sapiens (Human) - CCDC57 gene Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis. Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression. Indicus|evm.model.CM009509.1.990 Q71SP7 FAS_BOVIN 98.449 0.994856 1.00557 FASN - Fatty acid synthase - Bos taurus (Bovine) - FASN gene Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. Indicus|evm.model.CM009509.1.991 Q8C2P3 DUS1L_MOUSE 97.744 0.198496 1.4 Dus1l - tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like - Mus musculus (Mouse) - Dus1l gene Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Indicus|evm.model.CM009509.1.992 Q99LD4 CSN1_MOUSE 98.938 0.967078 1.03185 Gps1 - COP9 signalosome complex subunit 1 - Mus musculus (Mouse) - Gps1 gene Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity). Indicus|evm.model.CM009509.1.993 Q9Y644 RFNG_HUMAN 90.377 0.775244 0.927492 RFNG - Beta-1,3-N-acetylglucosaminyltransferase radical fringe - Homo sapiens (Human) - RFNG gene Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis. Indicus|evm.model.CM009509.1.994 Q1JP75 DCXR_BOVIN 96.596 0.502146 1.90984 DCXR - L-xylulose reductase - Bos taurus (Bovine) - DCXR gene Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules (By similarity). Indicus|evm.model.CM009509.1.995 P60764 RAC3_MOUSE 100.000 0.986577 0.776042 Rac3 - Ras-related C3 botulinum toxin substrate 3 precursor - Mus musculus (Mouse) - Rac3 gene Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. Indicus|evm.model.CM009509.1.996 Q96CN5 LRC45_HUMAN 90.351 0.15522 1.08657 LRRC45 - Leucine-rich repeat-containing protein 45 - Homo sapiens (Human) - LRRC45 gene Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. Indicus|evm.model.CM009509.1.997 Q2NKU0 CENPX_BOVIN 89.744 0.77 1.26582 CENPX - Centromere protein X - Bos taurus (Bovine) - CENPX gene DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own. Indicus|evm.model.CM009509.1.998 Q8VBT9 ASPC1_MOUSE 87.783 0.609418 0.656364 Aspscr1 - Tether containing UBX domain for GLUT4 - Mus musculus (Mouse) - Aspscr1 gene Enhances VCP methylation catalyzed by VCPKMT (By similarity). Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Indicus|evm.model.CM009509.1.999 Q6P988 NOTUM_HUMAN 93.651 0.753012 0.334677 NOTUM - Palmitoleoyl-protein carboxylesterase NOTUM precursor - Homo sapiens (Human) - NOTUM gene Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175). Indicus|evm.model.CM009509.1.1000 Q8R116 NOTUM_MOUSE 93.373 0.863874 0.379722 Notum - Palmitoleoyl-protein carboxylesterase NOTUM precursor - Mus musculus (Mouse) - Notum gene Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Indicus|evm.model.CM009509.1.1001 Q08DL4 MADL2_BOVIN 99.674 0.993506 1.00326 MYADML2 - Myeloid-associated differentiation marker-like protein 2 - Bos taurus (Bovine) - MYADML2 gene Indicus|evm.model.CM009509.1.1002 Q58DT4 P5CR1_BOVIN 100.000 0.993769 1.00313 PYCR1 - Pyrroline-5-carboxylate reductase 1, mitochondrial - Bos taurus (Bovine) - PYCR1 gene Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. Indicus|evm.model.CM009509.1.1003 O54790 MAFG_MOUSE 100.000 0.98773 1.00617 Mafg - Transcription factor MafG - Mus musculus (Mouse) - Mafg gene Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:16738329, PubMed:9679061). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:16738329, PubMed:9679061). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin gene expression when associated with NFE2L2 (By similarity). May be involved in signal transduction of extracellular H(+) (By similarity). Indicus|evm.model.CM009509.1.1004 Q0P595 SIR7_BOVIN 100.000 0.947743 1.0525 SIRT7 - NAD-dependent protein deacetylase sirtuin-7 - Bos taurus (Bovine) - SIRT7 gene NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on the context. Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. Also able to mediate deacetylation of histone H3 at 'Lys-36' (H3K36Ac) in the context of nucleosomes. Also mediates deacetylation of non-histone proteins, such as ATM, CDK9, DDX21, DDB1, FBL, FKBP5/FKBP51, GABPB1, RAN, RRP9/U3-55K and POLR1E/PAF53. Enriched in nucleolus where it stimulates transcription activity of the RNA polymerase I complex. Acts by mediating the deacetylation of the RNA polymerase I subunit POLR1E/PAF53, thereby promoting the association of RNA polymerase I with the rDNA promoter region and coding region. In response to metabolic stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased RNA polymerase I transcription. Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes pre-ribosomal RNA (pre-rRNA) cleavage at the 5'-terminal processing site by mediating deacetylation of RRP9/U3-55K, a core subunit of the U3 snoRNP complex. Mediates 'Lys-37' deacetylation of Ran, thereby regulating the nuclear export of NF-kappa-B subunit RELA/p65. Acts as a regulator of DNA damage repair by mediating deacetylation of ATM during the late stages of DNA damage response, promoting ATM dephosphorylation and deactivation. Suppresses the activity of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes by mediating deacetylation of DDB1, which prevents the interaction between DDB1 and CUL4 (CUL4A or CUL4B). Activates RNA polymerase II transcription by mediating deacetylation of CDK9, thereby promoting 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II. Deacetylates FBL, promoting histone-glutamine methyltransferase activity of FBL (By similarity). Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (By similarity). Regulates Akt/AKT1 activity by mediating deacetylation of FKBP5/FKBP51. Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability by mediating deacetylation and subsequent activation of DDX21, thereby overcoming R-loop-mediated stalling of RNA polymerases. In addition to protein deacetylase activity, also acts as protein-lysine deacylase (By similarity). Acts as a protein depropionylase by mediating depropionylation of Osterix (SP7), thereby regulating bone formation by osteoblasts (By similarity). Acts as a histone deglutarylase by mediating deglutarylation of histone H4 on 'Lys-91' (H4K91glu); a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Acts as a histone desuccinylase: in response to DNA damage, recruited to DNA double-strand breaks (DSBs) and catalyzes desuccinylation of histone H3 on 'Lys-122' (H3K122succ), thereby promoting chromatin condensation and DSB repair (By similarity). Also promotes DSB repair by promoting H3K18Ac deacetylation, regulating non-homologous end joining (NHEJ). Along with its role in DNA repair, required for chromosome synapsis during prophase I of female meiosis by catalyzing H3K18Ac deacetylation (By similarity). Involved in transcriptional repression of LINE-1 retrotransposon via H3K18Ac deacetylation, and promotes their association with the nuclear lamina. Required to stabilize ribosomal DNA (rDNA) heterochromatin and prevent cellular senescence induced by rDNA instability (By similarity). Acts as a negative regulator of SIRT1 by preventing autodeacetylation of SIRT1, restricting SIRT1 deacetylase activity (By similarity). Indicus|evm.model.CM009509.1.1005 Q5EA75 PCY2_BOVIN 95.577 0.995098 1.04884 PCYT2 - Ethanolamine-phosphate cytidylyltransferase - Bos taurus (Bovine) - PCYT2 gene Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway. Phosphatidylethanolamine is a dominant inner-leaflet phospholipid in cell membranes, where it plays a role in membrane function by structurally stabilizing membrane-anchored proteins, and participates in important cellular processes such as cell division, cell fusion, blood coagulation, and apoptosis. Indicus|evm.model.CM009509.1.1006 Q8MJV4 NPB_BOVIN 100.000 0.98374 1.0082 NPB - Neuropeptide B precursor - Bos taurus (Bovine) - NPB gene May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Indicus|evm.model.CM009509.1.1007 Q3ZCF6 APC11_BOVIN 100.000 0.976471 1.0119 ANAPC11 - Anaphase-promoting complex subunit 11 - Bos taurus (Bovine) - ANAPC11 gene Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). Indicus|evm.model.CM009509.1.1008 P19803 GDIR1_BOVIN 100.000 0.394175 2.52451 ARHGDIA - Rho GDP-dissociation inhibitor 1 - Bos taurus (Bovine) - ARHGDIA gene Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. Indicus|evm.model.CM009509.1.1009 Q2NKS3 PSMG3_BOVIN 87.912 0.909091 0.811475 PSMG3 - Proteasome assembly chaperone 3 - Bos taurus (Bovine) - PSMG3 gene Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes. Indicus|evm.model.CM009509.1.1010 P05307 PDIA1_BOVIN 99.412 0.899293 1.1098 P4HB - Protein disulfide-isomerase precursor - Bos taurus (Bovine) - P4HB gene This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Indicus|evm.model.CM009509.1.1011 Q9D119 PPR27_MOUSE 95.455 0.987097 1.00649 Ppp1r27 - Protein phosphatase 1 regulatory subunit 27 - Mus musculus (Mouse) - Ppp1r27 gene Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Indicus|evm.model.CM009509.1.1012 A8E4M4 MCRI1_BOVIN 97.938 0.979592 1.01031 MCRIP1 - Mapk-regulated corepressor-interacting protein 1 - Bos taurus (Bovine) - MCRIP1 gene The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. Indicus|evm.model.CM009509.1.1013 P47871 GLR_HUMAN 84.583 0.99375 1.00629 GCGR - Glucagon receptor precursor - Homo sapiens (Human) - GCGR gene G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009509.1.1014 P62907 RL10A_RAT 80.000 0.8625 0.368664 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Indicus|evm.model.CM009509.1.1015 Q9UBX3 DIC_HUMAN 90.592 0.993056 1.00348 SLC25A10 - Mitochondrial dicarboxylate carrier - Homo sapiens (Human) - SLC25A10 gene Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane. Indicus|evm.model.CM009509.1.1016 Q7YR75 RM12_BOVIN 100.000 0.98995 1.00505 MRPL12 - 39S ribosomal protein L12, mitochondrial precursor - Bos taurus (Bovine) - MRPL12 gene As a component of the mitochondrial large ribosomal subunit, it plays a role in mitochondrial translation. Associates with mitochondrial RNA polymerase to activate transcription. Indicus|evm.model.CM009509.1.1017 Q0V8S0 HGS_BOVIN 100.000 0.997429 1.00129 HGS - Hepatocyte growth factor-regulated tyrosine kinase substrate - Bos taurus (Bovine) - HGS gene Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). Indicus|evm.model.CM009509.1.1018 Q0P5N6 ARL16_HUMAN 85.065 0.665217 1.16751 ARL16 - ADP-ribosylation factor-like protein 16 - Homo sapiens (Human) - ARL16 gene Indicus|evm.model.CM009509.1.1019 Q17QR4 CC137_BOVIN 100.000 0.993174 1.00342 CCDC137 - Coiled-coil domain-containing protein 137 - Bos taurus (Bovine) - CCDC137 gene chromosome Indicus|evm.model.CM009509.1.1020 A7YVI8 OXLD1_BOVIN 98.693 0.987013 1.00654 OXLD1 - Oxidoreductase-like domain-containing protein 1 - Bos taurus (Bovine) - OXLD1 gene Indicus|evm.model.CM009509.1.1021 P04972 CNRG_BOVIN 100.000 0.977273 1.01149 PDE6G - Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma - Bos taurus (Bovine) - PDE6G gene Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Indicus|evm.model.CM009509.1.1022 Q9H1Z9 TSN10_HUMAN 70.000 0.796143 1.02254 TSPAN10 - Tetraspanin-10 - Homo sapiens (Human) - TSPAN10 gene Regulates maturation of the transmembrane metalloprotease ADAM10. Indicus|evm.model.CM009509.1.1023 P60670 NPL4_MOUSE 97.533 0.996716 1.00164 Nploc4 - Nuclear protein localization protein 4 homolog - Mus musculus (Mouse) - Nploc4 gene The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity). Indicus|evm.model.CM009509.1.1024 Q0VG06 FP100_HUMAN 72.778 0.997727 0.998865 FAAP100 - Fanconi anemia core complex-associated protein 100 - Homo sapiens (Human) - FAAP100 gene Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Indicus|evm.model.CM009509.1.1025 O18728 FSCN2_BOVIN 100.000 0.995943 1.00203 FSCN2 - Fascin-2 - Bos taurus (Bovine) - FSCN2 gene Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Indicus|evm.model.CM009509.1.1027 A2BDB0 ACTG_XENLA 100.000 0.994681 1.00267 actg1 - Actin, cytoplasmic 2 - Xenopus laevis (African clawed frog) - actg1 gene Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Indicus|evm.model.CM009509.1.1028 Q9P281 BAHC1_HUMAN 86.966 0.995699 0.176203 BAHCC1 - BAH and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - BAHCC1 gene Indicus|evm.model.CM009509.1.1029 Q9P281 BAHC1_HUMAN 81.520 0.940828 0.192118 BAHCC1 - BAH and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - BAHCC1 gene Indicus|evm.model.CM009509.1.1030 Q9P281 BAHC1_HUMAN 84.462 0.166781 0.552103 BAHCC1 - BAH and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - BAHCC1 gene Indicus|evm.model.CM009509.1.1032 Q5RC98 S38AA_PONAB 71.543 0.997227 0.96521 SLC38A10 - Putative sodium-coupled neutral amino acid transporter 10 - Pongo abelii (Sumatran orangutan) - SLC38A10 gene Putative sodium-dependent amino acid/proton antiporter. Indicus|evm.model.CM009509.1.1033 A1L188 NDUF8_HUMAN 90.769 0.48855 1.77027 NDUFAF8 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 - Homo sapiens (Human) - NDUFAF8 gene Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) (PubMed:27499296). Required to stabilize NDUFAF5 (PubMed:27499296). Indicus|evm.model.CM009509.1.1034 Q96N21 AP4AT_HUMAN 82.857 0.0977528 3.39048 TEPSIN - AP-4 complex accessory subunit Tepsin - Homo sapiens (Human) - TEPSIN gene Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Indicus|evm.model.CM009509.1.1035 Q6ZMQ8 LMTK1_HUMAN 74.126 0.998588 1.03057 AATK - Serine/threonine-protein kinase LMTK1 - Homo sapiens (Human) - AATK gene May be involved in neuronal differentiation. Indicus|evm.model.CM009509.1.1036 Q5EAD0 BAIP2_BOVIN 100.000 0.953358 1.02879 BAIAP2 - Brain-specific angiogenesis inhibitor 1-associated protein 2 - Bos taurus (Bovine) - BAIAP2 gene Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity). Indicus|evm.model.CM009509.1.1037 Q96FZ7 CHMP6_HUMAN 92.537 0.990099 1.00498 CHMP6 - Charged multivesicular body protein 6 - Homo sapiens (Human) - CHMP6 gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes. Indicus|evm.model.CM009509.1.1039 Q8K4Q0 RPTOR_MOUSE 97.004 0.998503 1.00075 Rptor - Regulatory-associated protein of mTOR - Mus musculus (Mouse) - Rptor gene Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis. mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (PubMed:33495318). Indicus|evm.model.CM009509.1.1041 P47971 NPTX1_RAT 97.704 0.994911 0.909722 Nptx1 - Neuronal pentraxin-1 precursor - Rattus norvegicus (Rat) - Nptx1 gene May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Indicus|evm.model.CM009509.1.1042 Q8C9A2 ENDOV_MOUSE 79.783 0.919732 0.884615 Endov - Endonuclease V - Mus musculus (Mouse) - Endov gene Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures. Indicus|evm.model.CM009509.1.1043 Q63HN8 RN213_HUMAN 69.235 0.997514 1.00442 RNF213 - E3 ubiquitin-protein ligase RNF213 - Homo sapiens (Human) - RNF213 gene E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892, PubMed:26278786, PubMed:26766444, PubMed:26126547). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity (PubMed:24658080, PubMed:26126547). Indicus|evm.model.CM009509.1.1045 Q63HN8 RN213_HUMAN 70.508 0.981196 0.960054 RNF213 - E3 ubiquitin-protein ligase RNF213 - Homo sapiens (Human) - RNF213 gene E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892, PubMed:26278786, PubMed:26766444, PubMed:26126547). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity (PubMed:24658080, PubMed:26126547). Indicus|evm.model.CM009509.1.1046 Q58DD2 S2611_BOVIN 100.000 0.996683 1.00166 SLC26A11 - Sodium-independent sulfate anion transporter - Bos taurus (Bovine) - SLC26A11 gene Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC). Indicus|evm.model.CM009509.1.1047 P51688 SPHM_HUMAN 87.776 0.98419 1.00797 SGSH - N-sulphoglucosamine sulphohydrolase precursor - Homo sapiens (Human) - SGSH gene Catalyzes a step in lysosomal heparan sulfate degradation. Indicus|evm.model.CM009509.1.1048 Q9BXL6 CAR14_HUMAN 78.465 0.997998 0.99502 CARD14 - Caspase recruitment domain-containing protein 14 - Homo sapiens (Human) - CARD14 gene Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Indicus|evm.model.CM009509.1.1049 Q3B8Q2 IF4A3_RAT 100.000 0.995146 1.00243 Eif4a3 - Eukaryotic initiation factor 4A-III - Rattus norvegicus (Rat) - Eif4a3 gene ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development. Indicus|evm.model.CM009509.1.1050 Q9MYM4 LYAG_BOVIN 99.787 0.455696 2.1921 GAA - Lysosomal alpha-glucosidase precursor - Bos taurus (Bovine) - GAA gene Essential for the degradation of glycogen in lysosomes (PubMed:10723725). Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans. Indicus|evm.model.CM009509.1.1051 Q8TBP0 TBC16_HUMAN 95.690 0.576412 0.784876 TBC1D16 - TBC1 domain family member 16 - Homo sapiens (Human) - TBC1D16 gene May act as a GTPase-activating protein for Rab family protein(s). Indicus|evm.model.CM009509.1.1052 O55187 CBX4_MOUSE 94.231 0.438559 0.856624 Cbx4 - E3 SUMO-protein ligase CBX4 - Mus musculus (Mouse) - Cbx4 gene E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Indicus|evm.model.CM009509.1.1053 Q9HC52 CBX8_HUMAN 90.659 0.994334 0.907455 CBX8 - Chromobox protein homolog 8 - Homo sapiens (Human) - CBX8 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Indicus|evm.model.CM009509.1.1054 Q14781 CBX2_HUMAN 86.090 0.996234 0.99812 CBX2 - Chromobox protein homolog 2 - Homo sapiens (Human) - CBX2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). Indicus|evm.model.CM009509.1.1055 Q5EZ72 ENPP7_RAT 79.529 0.944321 1.02278 Enpp7 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor - Rattus norvegicus (Rat) - Enpp7 gene Choline-specific phosphodiesterase that hydrolyzes sphingomyelin (SM) releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:16255717, PubMed:15708357). Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity (PubMed:16255717). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity). Indicus|evm.model.CM009509.1.1059 A6NFN3 RFOX3_HUMAN 97.436 0.95107 1.04808 RBFOX3 - RNA binding protein fox-1 homolog 3 - Homo sapiens (Human) - RBFOX3 gene Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). Indicus|evm.model.CM009509.1.1060 Q8NFI3 ENASE_HUMAN 78.976 0.994565 0.990579 ENGASE - Cytosolic endo-beta-N-acetylglucosaminidase - Homo sapiens (Human) - ENGASE gene Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol. Indicus|evm.model.CM009509.1.1061 Q9BXJ1 C1QT1_HUMAN 84.698 0.992857 0.996441 C1QTNF1 - Complement C1q tumor necrosis factor-related protein 1 precursor - Homo sapiens (Human) - C1QTNF1 gene extracellular space, integral component of plasma membrane, collagen binding, negative regulation of platelet activation, negative regulation of platelet aggregation, positive regulation of aldosterone secretion, positive regulation of cytosolic calcium ion concentration, positive regulation of gene expression Indicus|evm.model.CM009509.1.1062 Q8WVQ1 CANT1_HUMAN 88.279 0.811359 1.22943 CANT1 - Soluble calcium-activated nucleotidase 1 - Homo sapiens (Human) - CANT1 gene Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336). Indicus|evm.model.CM009509.1.1063 A7E3W2 LG3BP_BOVIN 99.279 0.996403 1.0018 LGALS3BP - Galectin-3-binding protein precursor - Bos taurus (Bovine) - LGALS3BP gene Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity). Indicus|evm.model.CM009509.1.1064 Q9TRZ7 TIMP2_RABIT 99.485 0.873303 1.13918 TIMP2 - Metalloproteinase inhibitor 2 - Oryctolagus cuniculus (Rabbit) - TIMP2 gene Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Indicus|evm.model.CM009509.1.1065 Q9P275 UBP36_HUMAN 71.290 0.998185 0.9813 USP36 - Ubiquitin carboxyl-terminal hydrolase 36 - Homo sapiens (Human) - USP36 gene Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Indicus|evm.model.CM009509.1.1066 Q15438 CYH1_HUMAN 98.489 0.9825 1.00503 CYTH1 - Cytohesin-1 - Homo sapiens (Human) - CYTH1 gene Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. Indicus|evm.model.CM009509.1.1067 Q9UFH2 DYH17_HUMAN 92.203 0.999552 1.00045 DNAH17 - Dynein axonemal heavy chain 17 - Homo sapiens (Human) - DNAH17 gene Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (Probable). Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating (PubMed:31178125). Indicus|evm.model.CM009509.1.1068 Q2KJ28 PGPS1_BOVIN 100.000 0.996409 1.0018 PGS1 - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial precursor - Bos taurus (Bovine) - PGS1 gene Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. Indicus|evm.model.CM009509.1.1069 Q9BEG9 SOCS3_BOVIN 100.000 0.991304 1.00437 SOCS3 - Suppressor of cytokine signaling 3 - Bos taurus (Bovine) - SOCS3 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Indicus|evm.model.CM009509.1.1070 O07051 LTAA_AERJA 47.603 0.740458 1.16272 ltaA - L-allo-threonine aldolase - Aeromonas jandaei - ltaA gene Stereospecifically catalyzes the interconversion of L-allo-threonine and glycine. Indicus|evm.model.CM009509.1.1071 A6NFC5 TM235_HUMAN 80.226 0.807512 0.955157 TMEM235 - Transmembrane protein 235 precursor - Homo sapiens (Human) - TMEM235 gene apical plasma membrane Indicus|evm.model.CM009509.1.1072 Q6J1J1 BIRC5_BOVIN 100.000 0.986014 1.00704 BIRC5 - Baculoviral IAP repeat-containing protein 5 - Bos taurus (Bovine) - BIRC5 gene Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity). Indicus|evm.model.CM009509.1.1073 Q63HM1 KFA_HUMAN 78.289 0.986971 1.0132 AFMID - Kynurenine formamidase - Homo sapiens (Human) - AFMID gene Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. Indicus|evm.model.CM009509.1.1074 A5D7R8 KITH_BOVIN 100.000 0.843416 1.18067 TK1 - Thymidine kinase, cytosolic - Bos taurus (Bovine) - TK1 gene thymidine kinase activity, zinc ion binding, thymidine metabolic process Indicus|evm.model.CM009509.1.1075 A7E3W5 SNG2_BOVIN 99.107 0.991111 1.00446 SYNGR2 - Synaptogyrin-2 - Bos taurus (Bovine) - SYNGR2 gene May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. Indicus|evm.model.CM009509.1.1076 Q8IU68 TMC8_HUMAN 81.881 0.990305 0.99449 TMC8 - Transmembrane channel-like protein 8 - Homo sapiens (Human) - TMC8 gene Probable ion channel. Indicus|evm.model.CM009509.1.1077 Q7Z403 TMC6_HUMAN 76.904 0.996305 1.0087 TMC6 - Transmembrane channel-like protein 6 - Homo sapiens (Human) - TMC6 gene Probable ion channel. Indicus|evm.model.CM009509.1.1078 Q9HCJ0 TNR6C_HUMAN 86.308 0.890326 1.14379 TNRC6C - Trinucleotide repeat-containing gene 6C protein - Homo sapiens (Human) - TNRC6C gene Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Indicus|evm.model.CM009509.1.1079 Q9UHD8 SEPT9_HUMAN 93.405 0.965458 0.988055 SEPTIN9 - Septin-9 - Homo sapiens (Human) - SEPTIN9 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. Indicus|evm.model.CM009509.1.1080 Q92503 S14L1_HUMAN 94.556 0.972067 1.0014 SEC14L1 - SEC14-like protein 1 - Homo sapiens (Human) - SEC14L1 gene May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608). Indicus|evm.model.CM009509.1.1081 Q3V5L5 MGT5B_HUMAN 93.238 0.934146 1.03535 MGAT5B - Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B - Homo sapiens (Human) - MGAT5B gene Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. Indicus|evm.model.CM009509.1.1082 Q4R495 MFS11_MACFA 95.991 0.995556 1.00223 MFSD11 - UNC93-like protein MFSD11 - Macaca fascicularis (Crab-eating macaque) - MFSD11 gene Indicus|evm.model.CM009509.1.1083 Q6PDU1 SRSF2_RAT 100.000 0.990991 1.00452 Srsf2 - Serine/arginine-rich splicing factor 2 - Rattus norvegicus (Rat) - Srsf2 gene Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity). Indicus|evm.model.CM009509.1.1084 Q86XA0 MET23_HUMAN 78.440 0.977477 1.16842 METTL23 - Methyltransferase-like protein 23 - Homo sapiens (Human) - METTL23 gene Probable methyltransferase. Indicus|evm.model.CM009509.1.1086 Q58DS6 JMJD6_BOVIN 100.000 0.730419 1.36228 JMJD6 - Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 - Bos taurus (Bovine) - JMJD6 gene Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (By similarity). Indicus|evm.model.CM009509.1.1087 Q9QZ39 SIA7A_MOUSE 71.462 0.716194 1.13878 St6galnac1 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 - Mus musculus (Mouse) - St6galnac1 gene Transfers CMP-NeuAc with an alpha-2,6-linkage to the GalNAc residues of GalNAc-O-Ser/Thr, Gal-beta-1,3-GalNAc-O-Ser/Thr and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-O-Ser/Thr are substrates. Higher activity towards GalNAc-O-Ser/Thr. Indicus|evm.model.CM009509.1.1088 Q9UJ37 SIA7B_HUMAN 81.067 0.994681 1.00535 ST6GALNAC2 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 - Homo sapiens (Human) - ST6GALNAC2 gene Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins. Indicus|evm.model.CM009509.1.1089 Q8WWM9 CYGB_HUMAN 96.667 0.98895 0.952632 CYGB - Cytoglobin - Homo sapiens (Human) - CYGB gene May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. Indicus|evm.model.CM009509.1.1090 Q00M95 RHDF2_CANLF 93.630 0.997593 1.00484 RHBDF2 - Inactive rhomboid protein 2 - Canis lupus familiaris (Dog) - RHBDF2 gene Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Indicus|evm.model.CM009509.1.1091 O02785 SNAT_BOVIN 98.551 0.990385 1.00483 AANAT - Serotonin N-acetyltransferase - Bos taurus (Bovine) - AANAT gene Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. Indicus|evm.model.CM009509.1.1092 O02785 SNAT_BOVIN 99.034 0.990385 1.00483 AANAT - Serotonin N-acetyltransferase - Bos taurus (Bovine) - AANAT gene Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. Indicus|evm.model.CM009509.1.1093 Q9C0C9 UBE2O_HUMAN 95.375 0.96972 0.996904 UBE2O - (E3-independent) E2 ubiquitin-conjugating enzyme - Homo sapiens (Human) - UBE2O gene E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Indicus|evm.model.CM009509.1.1094 Q9NYA1 SPHK1_HUMAN 83.110 0.781513 1.23958 SPHK1 - Sphingosine kinase 1 - Homo sapiens (Human) - SPHK1 gene Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (PubMed:20577214, PubMed:23602659, PubMed:29662056, PubMed:24929359, PubMed:11923095). In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis (PubMed:16118219). Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion (PubMed:20577214). In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway (PubMed:23935096). Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity (PubMed:28049734, PubMed:24929359). In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA (PubMed:25417698). Indicus|evm.model.CM009509.1.1095 Q08DW2 KPRA_BOVIN 100.000 0.919689 1.08427 PRPSAP1 - Phosphoribosyl pyrophosphate synthase-associated protein 1 - Bos taurus (Bovine) - PRPSAP1 gene Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. Indicus|evm.model.CM009509.1.1096 Q3V2A7 QRIC2_MOUSE 74.457 0.344053 2.78378 Qrich2 - Glutamine-rich protein 2 - Mus musculus (Mouse) - Qrich2 gene Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility. Indicus|evm.model.CM009509.1.1097 Q8IYN6 UBAD2_HUMAN 93.506 0.987097 0.945122 UBALD2 - UBA-like domain-containing protein 2 - Homo sapiens (Human) - UBALD2 gene Indicus|evm.model.CM009509.1.1098 Q96PX1 RN157_HUMAN 91.933 0.952104 1.01473 RNF157 - E3 ubiquitin ligase RNF157 - Homo sapiens (Human) - RNF157 gene E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764). Indicus|evm.model.CM009509.1.1099 Q92949 FOXJ1_HUMAN 95.724 0.995261 1.00238 FOXJ1 - Forkhead box protein J1 - Homo sapiens (Human) - FOXJ1 gene Transcription factor specifically required for the formation of motile cilia (PubMed:31630787). Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung. Indicus|evm.model.CM009509.1.1100 Q9UPT5 EXOC7_HUMAN 92.653 0.997175 0.963265 EXOC7 - Exocyst complex component 7 - Homo sapiens (Human) - EXOC7 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). Indicus|evm.model.CM009509.1.1101 O43603 GALR2_HUMAN 83.103 0.316027 2.28941 GALR2 - Galanin receptor type 2 - Homo sapiens (Human) - GALR2 gene Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). Indicus|evm.model.CM009509.1.1102 Q00004 SRP68_CANLF 96.308 0.996795 1.00322 SRP68 - Signal recognition particle subunit SRP68 - Canis lupus familiaris (Dog) - SRP68 gene Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. Indicus|evm.model.CM009509.1.1103 Q92817 EVPL_HUMAN 83.866 0.999017 1.00049 EVPL - Envoplakin - Homo sapiens (Human) - EVPL gene Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. Indicus|evm.model.CM009509.1.1104 Q00526 CDK3_HUMAN 89.109 0.986928 1.00328 CDK3 - Cyclin-dependent kinase 3 - Homo sapiens (Human) - CDK3 gene Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. Indicus|evm.model.CM009509.1.1105 Q86WV5 TEN1L_HUMAN 81.148 0.98374 1 TEN1 - CST complex subunit TEN1 - Homo sapiens (Human) - TEN1 gene Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Indicus|evm.model.CM009509.1.1106 Q3SZP5 ACOX1_BOVIN 90.405 0.996965 0.998485 ACOX1 - Peroxisomal acyl-coenzyme A oxidase 1 - Bos taurus (Bovine) - ACOX1 gene Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Indicus|evm.model.CM009509.1.1107 Q8TES7 FBF1_HUMAN 73.529 0.998214 0.988526 FBF1 - Fas-binding factor 1 - Homo sapiens (Human) - FBF1 gene Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. Indicus|evm.model.CM009509.1.1108 Q3ZBF3 RM38_BOVIN 99.474 0.994751 1.00263 MRPL38 - 39S ribosomal protein L38, mitochondrial precursor - Bos taurus (Bovine) - MRPL38 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Indicus|evm.model.CM009509.1.1109 Q6PJ69 TRI65_HUMAN 74.951 0.925319 1.0619 TRIM65 - Tripartite motif-containing protein 65 - Homo sapiens (Human) - TRIM65 gene cytosol, nucleoplasm, positive regulation of autophagy Indicus|evm.model.CM009509.1.1110 Q96LD4 TRI47_HUMAN 97.500 0.0714286 0.855799 TRIM47 - E3 ubiquitin-protein ligase TRIM47 - Homo sapiens (Human) - TRIM47 gene E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD. Indicus|evm.model.CM009509.1.1111 Q969T9 WBP2_HUMAN 96.169 0.992366 1.00383 WBP2 - WW domain-binding protein 2 - Homo sapiens (Human) - WBP2 gene Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Required for YAP1 coactivation function on PGR activity (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity). Indicus|evm.model.CM009509.1.1112 Q70J99 UN13D_HUMAN 87.879 0.99725 1.00092 UNC13D - Protein unc-13 homolog D - Homo sapiens (Human) - UNC13D gene Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. Indicus|evm.model.CM009509.1.1113 Q9C0B0 UNK_HUMAN 97.531 0.997534 1.00123 UNK - RING finger protein unkempt homolog - Homo sapiens (Human) - UNK gene Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). Indicus|evm.model.CM009509.1.1114 P84246 H33_RABIT 100.000 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009509.1.1115 A6H768 GALK1_BOVIN 99.745 0.994911 1.00255 GALK1 - Galactokinase - Bos taurus (Bovine) - GALK1 gene Major enzyme for galactose metabolism. Indicus|evm.model.CM009509.1.1116 P16144 ITB4_HUMAN 86.331 0.998901 0.998902 ITGB4 - Integrin beta-4 precursor - Homo sapiens (Human) - ITGB4 gene Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). Indicus|evm.model.CM009509.1.1117 Q9UHR5 S30BP_HUMAN 95.455 0.993528 1.00325 SAP30BP - SAP30-binding protein - Homo sapiens (Human) - SAP30BP gene Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes. Indicus|evm.model.CM009509.1.1118 O94762 RECQ5_HUMAN 80.343 0.996964 0.996973 RECQL5 - ATP-dependent DNA helicase Q5 - Homo sapiens (Human) - RECQL5 gene Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. Indicus|evm.model.CM009509.1.1119 Q96JP2 MY15B_HUMAN 70.421 0.492699 1.92484 MYO15B - Unconventional myosin-XVB - Homo sapiens (Human) - MYO15B gene Unknown, due to the absence of a functional motor domain. Indicus|evm.model.CM009509.1.1120 Q6P1M3 L2GL2_HUMAN 90.900 0.998045 1.00294 LLGL2 - LLGL scribble cell polarity complex component 2 - Homo sapiens (Human) - LLGL2 gene Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. Indicus|evm.model.CM009509.1.1121 Q7Z6J9 SEN54_HUMAN 83.239 0.996219 1.0057 TSEN54 - tRNA-splicing endonuclease subunit Sen54 - Homo sapiens (Human) - TSEN54 gene Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Indicus|evm.model.CM009509.1.1122 Q8WXE0 CSKI2_HUMAN 94.683 0.852856 0.859401 CASKIN2 - Caskin-2 - Homo sapiens (Human) - CASKIN2 gene cytoplasm, membrane Indicus|evm.model.CM009509.1.1123 Q12767 TMM94_HUMAN 94.053 0.998533 1.00516 TMEM94 - Transmembrane protein 94 - Homo sapiens (Human) - TMEM94 gene Indicus|evm.model.CM009509.1.1124 P62994 GRB2_RAT 100.000 0.990826 1.00461 Grb2 - Growth factor receptor-bound protein 2 - Rattus norvegicus (Rat) - Grb2 gene Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Indicus|evm.model.CM009509.1.1125 Q29RM1 TPC_BOVIN 100.000 0.99373 1.00314 SLC25A19 - Mitochondrial thiamine pyrophosphate carrier - Bos taurus (Bovine) - SLC25A19 gene Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria. Indicus|evm.model.CM009509.1.1126 Q3ZC21 MI4GD_BOVIN 100.000 0.991031 1.0045 MIF4GD - MIF4G domain-containing protein - Bos taurus (Bovine) - MIF4GD gene Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity). Indicus|evm.model.CM009509.1.1127 Q3T040 RT07_BOVIN 100.000 0.99177 1.00413 MRPS7 - 28S ribosomal protein S7, mitochondrial precursor - Bos taurus (Bovine) - MRPS7 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, ribosome, mRNA binding, rRNA binding, structural constituent of ribosome, mitochondrial translation, ribosomal small subunit assembly, translation Indicus|evm.model.CM009509.1.1128 Q8BMI3 GGA3_MOUSE 81.843 0.997195 0.993036 Gga3 - ADP-ribosylation factor-binding protein GGA3 - Mus musculus (Mouse) - Gga3 gene Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (By similarity). Indicus|evm.model.CM009509.1.1129 Q3ZC98 NUP85_BOVIN 99.848 0.996956 1.00152 NUP85 - Nuclear pore complex protein Nup85 - Bos taurus (Bovine) - NUP85 gene Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. Involved in nephrogenesis. Indicus|evm.model.CM009509.1.1130 P61959 SUMO2_RAT 98.876 0.733333 1.26316 Sumo2 - Small ubiquitin-related modifier 2 precursor - Rattus norvegicus (Rat) - Sumo2 gene Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). Indicus|evm.model.CM009509.1.1131 Q3T0T5 JUPI1_BOVIN 100.000 0.987097 1.00649 JPT1 - Jupiter microtubule associated homolog 1 - Bos taurus (Bovine) - JPT1 gene Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation. Indicus|evm.model.CM009509.1.1132 Q8TCD5 NT5C_HUMAN 84.184 0.898618 1.0796 NT5C - 5'(3')-deoxyribonucleotidase, cytosolic type - Homo sapiens (Human) - NT5C gene Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. Indicus|evm.model.CM009509.1.1133 Q9H6L4 ARMC7_HUMAN 86.294 0.984925 1.00505 ARMC7 - Armadillo repeat-containing protein 7 - Homo sapiens (Human) - ARMC7 gene Indicus|evm.model.CM009509.1.1134 O15375 MOT6_HUMAN 75.914 0.993576 0.924752 SLC16A5 - Monocarboxylate transporter 6 - Homo sapiens (Human) - SLC16A5 gene Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). Indicus|evm.model.CM009509.1.1135 Q14681 KCTD2_HUMAN 100.000 0.181598 3.14068 KCTD2 - BTB/POZ domain-containing protein KCTD2 - Homo sapiens (Human) - KCTD2 gene Cul3-RING ubiquitin ligase complex, cytoplasm, cullin family protein binding, protein-containing complex binding, proteasome-mediated ubiquitin-dependent protein catabolic process Indicus|evm.model.CM009509.1.1136 P13620 ATP5H_BOVIN 100.000 0.987654 1.00621 ATP5PD - ATP synthase subunit d, mitochondrial - Bos taurus (Bovine) - ATP5PD gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Indicus|evm.model.CM009509.1.1137 Q3T116 ICT1_BOVIN 99.515 0.990338 1.00485 MRPL58 - Peptidyl-tRNA hydrolase ICT1, mitochondrial precursor - Bos taurus (Bovine) - MRPL58 gene Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. Indicus|evm.model.CM009509.1.1138 Q86X02 CDR2L_HUMAN 94.409 0.995699 1 CDR2L - Cerebellar degeneration-related protein 2-like - Homo sapiens (Human) - CDR2L gene identical protein binding Indicus|evm.model.CM009509.1.1139 Q8IV36 HID1_HUMAN 91.656 0.857647 1.07868 HID1 - Protein HID1 - Homo sapiens (Human) - HID1 gene May play an important role in the development of cancers in a broad range of tissues. Indicus|evm.model.CM009509.1.1140 Q7RTS5 OTOP3_HUMAN 84.043 0.9947 0.949664 OTOP3 - Proton channel OTOP3 - Homo sapiens (Human) - OTOP3 gene Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Indicus|evm.model.CM009509.1.1141 Q7RTS6 OTOP2_HUMAN 86.702 0.996454 1.00356 OTOP2 - Proton channel OTOP2 - Homo sapiens (Human) - OTOP2 gene Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Indicus|evm.model.CM009509.1.1142 Q495M9 USH1G_HUMAN 94.805 0.99568 1.00434 USH1G - Usher syndrome type-1G protein - Homo sapiens (Human) - USH1G gene Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Indicus|evm.model.CM009509.1.1143 Q6Q311 RS25_SHEEP 89.600 0.983871 0.992 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Indicus|evm.model.CM009509.1.1144 A2VE15 FADS6_BOVIN 100.000 0.994169 1.00292 FADS6 - Fatty acid desaturase 6 - Bos taurus (Bovine) - FADS6 gene Indicus|evm.model.CM009509.1.1145 P08165 ADRO_BOVIN 99.390 0.995943 1.00203 FDXR - NADPH:adrenodoxin oxidoreductase, mitochondrial precursor - Bos taurus (Bovine) - FDXR gene Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Indicus|evm.model.CM009509.1.1146 Q01098 NMDE3_MOUSE 94.928 0.811101 0.901533 Grin2c - Glutamate receptor ionotropic, NMDA 2C precursor - Mus musculus (Mouse) - Grin2c gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1377365). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:1377365). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex (PubMed:27922130). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:8987814). Indicus|evm.model.CM009509.1.1147 Q5RCV1 TM104_PONAB 86.089 0.995624 0.921371 TMEM104 - Transmembrane protein 104 - Pongo abelii (Sumatran orangutan) - TMEM104 gene Indicus|evm.model.CM009509.1.1148 Q9BTE0 NAT9_HUMAN 87.923 0.990338 1 NAT9 - N-acetyltransferase 9 - Homo sapiens (Human) - NAT9 gene protein-containing complex, protein acetylation Indicus|evm.model.CM009509.1.1149 Q3SZK8 NHRF1_BOVIN 100.000 0.99458 1.00272 SLC9A3R1 - Na(+)/H(+) exchange regulatory cofactor NHE-RF1 - Bos taurus (Bovine) - SLC9A3R1 gene Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Indicus|evm.model.CM009509.1.1150 Q96AX2 RAB37_HUMAN 93.274 0.991071 1.00448 RAB37 - Ras-related protein Rab-37 precursor - Homo sapiens (Human) - RAB37 gene azurophil granule membrane, endoplasmic reticulum-Golgi intermediate compartment, endosome, Golgi apparatus, plasma membrane, specific granule membrane, neutrophil degranulation Indicus|evm.model.CM009509.1.1151 Q29RR0 RAB26_BOVIN 62.162 0.473684 0.296875 RAB26 - Ras-related protein Rab-26 - Bos taurus (Bovine) - RAB26 gene Participates in exocrine secretion: regulates the secretion of acinar granules in the parotid gland. Indicus|evm.model.CM009509.1.1152 Q6UXZ3 CLM5_HUMAN 55.556 0.357333 1.93299 CD300LD - CMRF35-like molecule 5 precursor - Homo sapiens (Human) - CD300LD gene plasma membrane, transmembrane signaling receptor activity, regulation of immune response Indicus|evm.model.CM009509.1.1153 Q496F6 CLM2_HUMAN 61.333 0.532847 1.33659 CD300E - CMRF35-like molecule 2 precursor - Homo sapiens (Human) - CD300E gene Probably acts as an activating receptor. Indicus|evm.model.CM009509.1.1154 Q8TDQ1 CLM1_HUMAN 62.931 0.281863 1.4069 CD300LF - CMRF35-like molecule 1 precursor - Homo sapiens (Human) - CD300LF gene Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). Indicus|evm.model.CM009509.1.1155 A0A0K2S4Q6 CD3CH_HUMAN 58.252 0.919283 1.10945 CD300H - Protein CD300H precursor - Homo sapiens (Human) - CD300H gene May play an important role in innate immunity by mediating a signal for the production of a neutrophil chemoattractant. Indicus|evm.model.CM009509.1.1156 Q08708 CLM6_HUMAN 51.339 0.986425 0.986607 CD300C - CMRF35-like molecule 6 precursor - Homo sapiens (Human) - CD300C gene integral component of plasma membrane, plasma membrane, transmembrane signaling receptor activity, cellular defense response, regulation of immune response Indicus|evm.model.CM009509.1.1157 Q9UGN4 CLM8_HUMAN 54.310 0.506787 0.73913 CD300A - CMRF35-like molecule 8 precursor - Homo sapiens (Human) - CD300A gene Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). Indicus|evm.model.CM009509.1.1158 Q8TDQ1 CLM1_HUMAN 56.716 0.328358 0.693103 CD300LF - CMRF35-like molecule 1 precursor - Homo sapiens (Human) - CD300LF gene Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). Indicus|evm.model.CM009509.1.1159 Q08708 CLM6_HUMAN 54.688 0.413333 1.33929 CD300C - CMRF35-like molecule 6 precursor - Homo sapiens (Human) - CD300C gene integral component of plasma membrane, plasma membrane, transmembrane signaling receptor activity, cellular defense response, regulation of immune response Indicus|evm.model.CM009509.1.1160 Q2YDG0 GPC5C_BOVIN 100.000 0.892713 1.11765 GPRC5C - G-protein coupled receptor family C group 5 member C precursor - Bos taurus (Bovine) - GPRC5C gene This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Indicus|evm.model.CM009509.1.1161 Q7Z601 GP142_HUMAN 81.395 0.974432 0.761905 GPR142 - Probable G-protein coupled receptor 142 - Homo sapiens (Human) - GPR142 gene Orphan receptor. Indicus|evm.model.CM009509.1.1162 Q9DB72 BTBDH_MOUSE 93.096 0.995825 1.00209 Btbd17 - BTB/POZ domain-containing protein 17 precursor - Mus musculus (Mouse) - Btbd17 gene Indicus|evm.model.CM009509.1.1163 Q9GZS0 DNAI2_HUMAN 89.249 0.36 2.68595 DNAI2 - Dynein axonemal intermediate chain 2 - Homo sapiens (Human) - DNAI2 gene Part of the dynein complex of respiratory cilia. Indicus|evm.model.CM009509.1.1164 Q9BSA4 TTYH2_HUMAN 82.772 0.996255 1 TTYH2 - Protein tweety homolog 2 - Homo sapiens (Human) - TTYH2 gene Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation. Indicus|evm.model.CM009509.1.1165 P63174 RL38_RAT 100.000 0.971831 1.01429 Rpl38 - 60S ribosomal protein L38 - Rattus norvegicus (Rat) - Rpl38 gene cytosolic large ribosomal subunit, eukaryotic 80S initiation complex, polysomal ribosome, postsynaptic density, synapse, structural constituent of ribosome, 90S preribosome assembly, axial mesoderm development, cytoplasmic translation, middle ear morphogenesis Indicus|evm.model.CM009509.1.1169 Q6V4S5 SDK2_MOUSE 96.226 0.553191 0.0431985 Sdk2 - Protein sidekick-2 precursor - Mus musculus (Mouse) - Sdk2 gene Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion (PubMed:26287463). Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion (PubMed:26287463). Promotes synaptic connectivity via homophilic interactions (PubMed:26287463). Indicus|evm.model.CM009509.1.1170 Q58EX2 SDK2_HUMAN 91.572 0.454721 0.955801 SDK2 - Protein sidekick-2 precursor - Homo sapiens (Human) - SDK2 gene Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. Indicus|evm.model.CM009509.1.1172 Q9H3Q1 BORG4_HUMAN 77.686 0.994253 0.977528 CDC42EP4 - Cdc42 effector protein 4 - Homo sapiens (Human) - CDC42EP4 gene Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. Indicus|evm.model.CM009509.1.1173 Q59T36 YTH1_CANAL 58.621 0.28866 0.451163 YTH1 - mRNA 3'-end-processing protein YTH1 - Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) - YTH1 gene Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing. Indicus|evm.model.CM009509.1.1174 Q9BSJ5 CQ080_HUMAN 54.355 0.982111 0.917898 C17orf80 - Uncharacterized protein C17orf80 - Homo sapiens (Human) - C17orf80 gene extracellular exosome Indicus|evm.model.CM009509.1.1175 Q969W3 F104A_HUMAN 82.065 0.978261 0.989247 FAM104A - Protein FAM104A - Homo sapiens (Human) - FAM104A gene Indicus|evm.model.CM009509.1.1176 Q8WTW3 COG1_HUMAN 81.180 0.997901 0.972449 COG1 - Conserved oligomeric Golgi complex subunit 1 - Homo sapiens (Human) - COG1 gene Required for normal Golgi function. Indicus|evm.model.CM009509.1.1178 P34993 SSR2_BOVIN 99.728 0.99458 1.00272 SSTR2 - Somatostatin receptor type 2 - Bos taurus (Bovine) - SSTR2 gene Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization (By similarity). Indicus|evm.model.CM009509.1.1179 Q2YDD4 S39AB_BOVIN 97.654 0.99403 0.982405 SLC39A11 - Zinc transporter ZIP11 - Bos taurus (Bovine) - SLC39A11 gene Functions as a cellular zinc transporter. Indicus|evm.model.CM009509.1.1182 F1LYL9 SOX9_RAT 85.965 0.5 0.77712 Sox9 - Transcription factor SOX-9 - Rattus norvegicus (Rat) - Sox9 gene Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (By similarity). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:26150426). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). Indicus|evm.model.CM009509.1.1191 O19182 KCNJ2_BOVIN 100.000 0.995327 1.00234 KCNJ2 - Inward rectifier potassium channel 2 - Bos taurus (Bovine) - KCNJ2 gene Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). Indicus|evm.model.CM009509.1.1192 Q9NPI9 KCJ16_HUMAN 89.286 0.995249 1.00718 KCNJ16 - Inward rectifier potassium channel 16 - Homo sapiens (Human) - KCNJ16 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201). Indicus|evm.model.CM009509.1.1196 Q5E9X2 MP2K6_BOVIN 100.000 0.99403 1.00299 MAP2K6 - Dual specificity mitogen-activated protein kinase kinase 6 - Bos taurus (Bovine) - MAP2K6 gene Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases (By similarity). Indicus|evm.model.CM009509.1.1197 Q8WWZ7 ABCA5_HUMAN 87.444 0.998081 0.951888 ABCA5 - Cholesterol transporter ABCA5 - Homo sapiens (Human) - ABCA5 gene Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity). Indicus|evm.model.CM009509.1.1198 Q8WWZ4 ABCAA_HUMAN 69.171 0.963659 1.03435 ABCA10 - ATP-binding cassette sub-family A member 10 - Homo sapiens (Human) - ABCA10 gene Probable transporter which may play a role in macrophage lipid transport and homeostasis. Indicus|evm.model.CM009509.1.1199 Q8N139 ABCA6_HUMAN 71.869 0.988542 0.971552 ABCA6 - ATP-binding cassette sub-family A member 6 - Homo sapiens (Human) - ABCA6 gene Probable transporter which may play a role in macrophage lipid transport and homeostasis. Indicus|evm.model.CM009509.1.1200 Q8IUA7 ABCA9_HUMAN 77.228 0.948326 1.04865 ABCA9 - ATP-binding cassette sub-family A member 9 - Homo sapiens (Human) - ABCA9 gene Transporter that may play a role in monocyte differentiation and lipid transport and homeostasis. Indicus|evm.model.CM009509.1.1202 Q96MK3 FA20A_HUMAN 90.878 0.64693 0.842884 FAM20A - Pseudokinase FAM20A precursor - Homo sapiens (Human) - FAM20A gene Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. Indicus|evm.model.CM009509.1.1203 P00514 KAP0_BOVIN 100.000 0.994751 1.00263 PRKAR1A - cAMP-dependent protein kinase type I-alpha regulatory subunit - Bos taurus (Bovine) - PRKAR1A gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Indicus|evm.model.CM009509.1.1205 Q32KH9 ARSG_CANLF 85.455 0.449454 1.36822 ARSG - Arylsulfatase G precursor - Canis lupus familiaris (Dog) - ARSG gene Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Indicus|evm.model.CM009509.1.1206 Q96EG1 ARSG_HUMAN 80.303 0.831224 0.451429 ARSG - Arylsulfatase G precursor - Homo sapiens (Human) - ARSG gene Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Indicus|evm.model.CM009509.1.1207 B1AT66 MOT7_MOUSE 78.131 0.794562 1.09061 Slc16a6 - Monocarboxylate transporter 7 - Mus musculus (Mouse) - Slc16a6 gene Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). Indicus|evm.model.CM009509.1.1208 Q86W34 AMZ2_HUMAN 80.278 0.962466 1.03611 AMZ2 - Archaemetzincin-2 - Homo sapiens (Human) - AMZ2 gene Probable zinc metalloprotease. Indicus|evm.model.CM009509.1.1209 Q14344 GNA13_HUMAN 99.034 0.844262 0.647215 GNA13 - Guanine nucleotide-binding protein subunit alpha-13 - Homo sapiens (Human) - GNA13 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). Indicus|evm.model.CM009509.1.1210 P27601 GNA13_MOUSE 89.474 0.551471 0.360743 Gna13 - Guanine nucleotide-binding protein subunit alpha-13 - Mus musculus (Mouse) - Gna13 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:21212405, PubMed:19151758, PubMed:16388592). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:16388592). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (PubMed:19151758, PubMed:21212405). Promotes tumor cell invasion and metastasis by activating Rho/ROCK signaling pathway (By similarity). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity). Indicus|evm.model.CM009509.1.1212 O46469 RGS9_BOVIN 94.480 0.696124 1.33264 RGS9 - Regulator of G-protein signaling 9 - Bos taurus (Bovine) - RGS9 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction. Indicus|evm.model.CM009509.1.1214 Q9Y2T1 AXIN2_HUMAN 80.969 0.997613 0.994069 AXIN2 - Axin-2 - Homo sapiens (Human) - AXIN2 gene Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. Indicus|evm.model.CM009509.1.1216 P17690 APOH_BOVIN 98.261 0.99422 1.0029 APOH - Beta-2-glycoprotein 1 precursor - Bos taurus (Bovine) - APOH gene Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. Indicus|evm.model.CM009509.1.1219 P04409 KPCA_BOVIN 92.174 0.667085 1.18452 PRKCA - Protein kinase C alpha type - Bos taurus (Bovine) - PRKCA gene Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation. In cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Depending on the cell type, exhibits anti-apoptotic function and protects cells from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, or mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity). Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteosomal degradation (By similarity). Indicus|evm.model.CM009509.1.1221 Q8VHW4 CCG5_MOUSE 92.000 0.992754 1.00364 Cacng5 - Voltage-dependent calcium channel gamma-5 subunit - Mus musculus (Mouse) - Cacng5 gene Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). Indicus|evm.model.CM009509.1.1222 Q9UBN1 CCG4_HUMAN 73.684 0.193717 0.584098 CACNG4 - Voltage-dependent calcium channel gamma-4 subunit - Homo sapiens (Human) - CACNG4 gene Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:21172611). Indicus|evm.model.CM009509.1.1223 Q8VHW9 CCG4_RAT 94.882 0.914815 0.825688 Cacng4 - Voltage-dependent calcium channel gamma-4 subunit - Rattus norvegicus (Rat) - Cacng4 gene Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:17880894, PubMed:19234459). Indicus|evm.model.CM009509.1.1224 Q08DE1 CCG1_BOVIN 100.000 0.991071 1.00448 CACNG1 - Voltage-dependent calcium channel gamma-1 subunit - Bos taurus (Bovine) - CACNG1 gene Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. Indicus|evm.model.CM009509.1.1225 P42694 HELZ_HUMAN 89.887 0.858642 0.735839 HELZ - Probable helicase with zinc finger domain - Homo sapiens (Human) - HELZ gene May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. Indicus|evm.model.CM009509.1.1226 P42694 HELZ_HUMAN 92.576 0.863636 0.135942 HELZ - Probable helicase with zinc finger domain - Homo sapiens (Human) - HELZ gene May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. Indicus|evm.model.CM009509.1.1227 P42694 HELZ_HUMAN 95.349 0.987212 0.201339 HELZ - Probable helicase with zinc finger domain - Homo sapiens (Human) - HELZ gene May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. Indicus|evm.model.CM009510.1.1 Q8NGL1 OR5DI_HUMAN 60.000 0.958333 0.383387 OR5D18 - Olfactory receptor 5D18 - Homo sapiens (Human) - OR5D18 gene Odorant receptor. Indicus|evm.model.CM009510.1.4 Q8NH69 OR5W2_HUMAN 58.209 0.628571 0.33871 OR5W2 - Olfactory receptor 5W2 - Homo sapiens (Human) - OR5W2 gene Odorant receptor. Indicus|evm.model.CM009510.1.5 Q13606 OR5I1_HUMAN 84.052 0.995455 0.700637 OR5I1 - Olfactory receptor 5I1 - Homo sapiens (Human) - OR5I1 gene Odorant receptor. Indicus|evm.model.CM009510.1.8 Q32L17 SPZ1_BOVIN 98.383 0.994624 1.0027 SPZ1 - Spermatogenic leucine zipper protein 1 - Bos taurus (Bovine) - SPZ1 gene Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity). Indicus|evm.model.CM009510.1.9 Q08DA5 PANK3_BOVIN 100.000 0.994609 1.0027 PANK3 - Pantothenate kinase 3 - Bos taurus (Bovine) - PANK3 gene Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Indicus|evm.model.CM009510.1.10 O75094 SLIT3_HUMAN 86.570 0.938964 0.925148 SLIT3 - Slit homolog 3 protein precursor - Homo sapiens (Human) - SLIT3 gene May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors. Indicus|evm.model.CM009510.1.12 O88280 SLIT3_RAT 95.652 0.688442 0.130663 Slit3 - Slit homolog 3 protein precursor - Rattus norvegicus (Rat) - Slit3 gene May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors. Indicus|evm.model.CM009510.1.13 Q08DR9 SPDLY_BOVIN 99.502 0.969404 1.02985 SPDL1 - Protein Spindly - Bos taurus (Bovine) - SPDL1 gene Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Plays a role in cell migration (By similarity). Indicus|evm.model.CM009510.1.14 Q92608 DOCK2_HUMAN 94.105 0.987912 0.497268 DOCK2 - Dedicator of cytokinesis protein 2 - Homo sapiens (Human) - DOCK2 gene Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. Indicus|evm.model.CM009510.1.15 A6NMK8 INY2B_HUMAN 79.626 0.996071 0.951402 INSYN2B - Protein INSYN2B - Homo sapiens (Human) - INSYN2B gene Indicus|evm.model.CM009510.1.16 Q92608 DOCK2_HUMAN 92.511 0.862944 0.430601 DOCK2 - Dedicator of cytokinesis protein 2 - Homo sapiens (Human) - DOCK2 gene Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. Indicus|evm.model.CM009510.1.17 Q92608 DOCK2_HUMAN 79.412 0.563025 0.0650273 DOCK2 - Dedicator of cytokinesis protein 2 - Homo sapiens (Human) - DOCK2 gene Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. Indicus|evm.model.CM009510.1.18 Q12951 FOXI1_HUMAN 81.675 0.994737 1.00529 FOXI1 - Forkhead box protein I1 - Homo sapiens (Human) - FOXI1 gene Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity). Indicus|evm.model.CM009510.1.19 Q8BUR4 DOCK1_MOUSE 66.667 0.126984 0.270241 Dock1 - Dedicator of cytokinesis protein 1 - Mus musculus (Mouse) - Dock1 gene Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Indicus|evm.model.CM009510.1.20 C9J3I9 CE058_HUMAN 70.000 0.632 1.22549 C5orf58 - Putative uncharacterized protein C5orf58 - Homo sapiens (Human) - C5orf58 gene Indicus|evm.model.CM009510.1.21 Q13094 LCP2_HUMAN 83.333 0.996255 1.00188 LCP2 - Lymphocyte cytosolic protein 2 - Homo sapiens (Human) - LCP2 gene Involved in T-cell antigen receptor mediated signaling. Indicus|evm.model.CM009510.1.22 Q28067 KCMB1_BOVIN 100.000 0.989583 1.00524 KCNMB1 - Calcium-activated potassium channel subunit beta-1 - Bos taurus (Bovine) - KCNMB1 gene Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity). Indicus|evm.model.CM009510.1.25 Q9JJ57 KCIP1_MOUSE 98.469 0.955882 0.898678 Kcnip1 - Kv channel-interacting protein 1 - Mus musculus (Mouse) - Kcnip1 gene Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND2/Kv4.2 currents (PubMed:14572458). In vitro, modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface. Indicus|evm.model.CM009510.1.26 Q5EA06 GBRP_BOVIN 100.000 0.995465 1.00227 GABRP - Gamma-aminobutyric acid receptor subunit pi precursor - Bos taurus (Bovine) - GABRP gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone (By similarity). Indicus|evm.model.CM009510.1.27 Q9H2T7 RBP17_HUMAN 94.124 0.997861 0.859375 RANBP17 - Ran-binding protein 17 - Homo sapiens (Human) - RANBP17 gene May function as a nuclear transport receptor. Indicus|evm.model.CM009510.1.28 O43711 TLX3_HUMAN 98.969 0.993151 1.00344 TLX3 - T-cell leukemia homeobox protein 3 - Homo sapiens (Human) - TLX3 gene chromatin, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, animal organ development, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009510.1.29 Q3T160 NPM_BOVIN 98.596 0.690998 1.39796 NPM1 - Nucleophosmin - Bos taurus (Bovine) - NPM1 gene Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Indicus|evm.model.CM009510.1.30 P62246 RS15A_RAT 100.000 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Indicus|evm.model.CM009510.1.31 O89101 FGF18_MOUSE 99.194 0.97619 0.608696 Fgf18 - Fibroblast growth factor 18 precursor - Mus musculus (Mouse) - Fgf18 gene Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity). Indicus|evm.model.CM009510.1.33 Q9DAL0 SIM23_MOUSE 63.971 0.948905 1.00735 Smim23 - Small integral membrane protein 23 - Mus musculus (Mouse) - Smim23 gene Indicus|evm.model.CM009510.1.34 Q15120 PDK3_HUMAN 82.039 0.97619 0.517241 PDK3 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial precursor - Homo sapiens (Human) - PDK3 gene Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. Indicus|evm.model.CM009510.1.37 E1BK52 STK10_BOVIN 99.896 0.996901 1.00207 STK10 - Serine/threonine-protein kinase 10 - Bos taurus (Bovine) - STK10 gene Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo (By similarity). Indicus|evm.model.CM009510.1.38 A8MZ26 EFCB9_HUMAN 69.474 0.847534 1.13198 EFCAB9 - EF-hand calcium-binding domain-containing protein 9 - Homo sapiens (Human) - EFCAB9 gene pH-dependent Ca(2+) sensor required to activate the CatSper channel, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel. Indicus|evm.model.CM009510.1.39 Q5EAE3 UBTD2_BOVIN 100.000 0.991489 1.00427 UBTD2 - Ubiquitin domain-containing protein 2 - Bos taurus (Bovine) - UBTD2 gene Indicus|evm.model.CM009510.1.40 A1X283 SPD2B_HUMAN 85.905 0.993341 0.989023 SH3PXD2B - SH3 and PX domain-containing protein 2B - Homo sapiens (Human) - SH3PXD2B gene Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). Indicus|evm.model.CM009510.1.41 A8MQ27 NEU1B_HUMAN 93.450 0.539007 0.762162 NEURL1B - E3 ubiquitin-protein ligase NEURL1B - Homo sapiens (Human) - NEURL1B gene E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands. Indicus|evm.model.CM009510.1.42 P28562 DUS1_HUMAN 96.730 0.994565 1.00272 DUSP1 - Dual specificity protein phosphatase 1 - Homo sapiens (Human) - DUSP1 gene Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. Indicus|evm.model.CM009510.1.44 Q969X5 ERGI1_HUMAN 97.586 0.993127 1.00345 ERGIC1 - Endoplasmic reticulum-Golgi intermediate compartment protein 1 - Homo sapiens (Human) - ERGIC1 gene Possible role in transport between endoplasmic reticulum and Golgi. Indicus|evm.model.CM009510.1.45 Q9UNX3 RL26L_HUMAN 93.377 0.802139 1.28966 RPL26L1 - 60S ribosomal protein L26-like 1 - Homo sapiens (Human) - RPL26L1 gene cytosolic large ribosomal subunit, extracellular exosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, ribosomal large subunit biogenesis Indicus|evm.model.CM009510.1.46 Q8IUR6 CRERF_HUMAN 97.966 0.996875 1.00156 CREBRF - CREB3 regulatory factor - Homo sapiens (Human) - CREBRF gene Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. Indicus|evm.model.CM009510.1.47 Q12981 SEC20_HUMAN 94.737 0.991266 1.00439 BNIP1 - Vesicle transport protein SEC20 - Homo sapiens (Human) - BNIP1 gene As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311). Plays also a role in apoptosis (PubMed:7954800, PubMed:15272311, PubMed:23896122). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable). Indicus|evm.model.CM009510.1.50 P52952 NKX25_HUMAN 94.753 0.993827 1 NKX2-5 - Homeobox protein Nkx-2.5 - Homo sapiens (Human) - NKX2-5 gene Transcription factor required for the development of the heart and the spleen (PubMed:22560297). During heart development, acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). Indicus|evm.model.CM009510.1.51 O97561 STC2_MACNE 91.722 0.993399 1.00331 STC2 - Stanniocalcin-2 precursor - Macaca nemestrina (Pig-tailed macaque) - STC2 gene Has an anti-hypocalcemic action on calcium and phosphate homeostasis. Indicus|evm.model.CM009510.1.52 Q5SQY2 BOD1_MOUSE 97.794 0.597345 1.30636 Bod1 - Biorientation of chromosomes in cell division protein 1 - Mus musculus (Mouse) - Bod1 gene Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Indicus|evm.model.CM009510.1.53 Q3ZBH3 CD151_BOVIN 52.510 0.987069 0.916996 CD151 - CD151 antigen - Bos taurus (Bovine) - CD151 gene Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Indicus|evm.model.CM009510.1.54 Q17RY0 CPEB4_HUMAN 98.491 0.99723 0.990398 CPEB4 - Cytoplasmic polyadenylation element-binding protein 4 - Homo sapiens (Human) - CPEB4 gene Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). Indicus|evm.model.CM009510.1.55 Q569G3 CE047_HUMAN 63.889 0.415663 0.943182 C5orf47 - Uncharacterized protein C5orf47 - Homo sapiens (Human) - C5orf47 gene Indicus|evm.model.CM009510.1.56 Q569G3 CE047_HUMAN 70.270 0.73 0.568182 C5orf47 - Uncharacterized protein C5orf47 - Homo sapiens (Human) - C5orf47 gene Indicus|evm.model.CM009510.1.57 Q0VCZ0 NSG2_BOVIN 100.000 0.518072 0.48538 NSG2 - Neuronal vesicle trafficking-associated protein 2 - Bos taurus (Bovine) - NSG2 gene cytoplasmic vesicle membrane, dendrite, early endosome, endosome, Golgi cis cisterna membrane, integral component of membrane, late endosome, multivesicular body membrane, trans-Golgi network membrane, clathrin light chain binding Indicus|evm.model.CM009510.1.58 Q3ZBZ8 STIP1_BOVIN 80.712 0.94081 0.59116 STIP1 - Stress-induced-phosphoprotein 1 - Bos taurus (Bovine) - STIP1 gene Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Indicus|evm.model.CM009510.1.59 Q3ZBZ8 STIP1_BOVIN 91.908 0.988506 0.320442 STIP1 - Stress-induced-phosphoprotein 1 - Bos taurus (Bovine) - STIP1 gene Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Indicus|evm.model.CM009510.1.60 P02316 HMGN1_BOVIN 96.040 0.980198 1 HMGN1 - Non-histone chromosomal protein HMG-14 - Bos taurus (Bovine) - HMGN1 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). Indicus|evm.model.CM009510.1.61 Q0VCZ0 NSG2_BOVIN 95.283 0.860656 0.71345 NSG2 - Neuronal vesicle trafficking-associated protein 2 - Bos taurus (Bovine) - NSG2 gene cytoplasmic vesicle membrane, dendrite, early endosome, endosome, Golgi cis cisterna membrane, integral component of membrane, late endosome, multivesicular body membrane, trans-Golgi network membrane, clathrin light chain binding Indicus|evm.model.CM009510.1.62 Q4R4U3 PRPS1_MACFA 76.812 0.731183 0.292453 PRPS1 - Ribose-phosphate pyrophosphokinase 1 - Macaca fascicularis (Crab-eating macaque) - PRPS1 gene Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Indicus|evm.model.CM009510.1.63 O95476 CNEP1_HUMAN 88.288 0.982143 0.459016 CTDNEP1 - CTD nuclear envelope phosphatase 1 - Homo sapiens (Human) - CTDNEP1 gene Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. Indicus|evm.model.CM009510.1.64 Q0P5C3 MSX2_BOVIN 100.000 0.992537 1.00375 MSX2 - Homeobox protein MSX-2 - Bos taurus (Bovine) - MSX2 gene Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). Indicus|evm.model.CM009510.1.65 Q9Y6X4 F169A_HUMAN 78.358 0.996727 0.91194 FAM169A - Soluble lamin-associated protein of 75 kDa - Homo sapiens (Human) - FAM169A gene Indicus|evm.model.CM009510.1.66 Q3SX11 NSA2_BOVIN 100.000 0.992337 1.00385 NSA2 - Ribosome biogenesis protein NSA2 homolog - Bos taurus (Bovine) - NSA2 gene Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). Indicus|evm.model.CM009510.1.67 A6QNM2 RRF2M_BOVIN 100.000 0.997429 1.00129 GFM2 - Ribosome-releasing factor 2, mitochondrial - Bos taurus (Bovine) - GFM2 gene Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. Indicus|evm.model.CM009510.1.68 P49614 HEXB_FELCA 74.853 0.944238 1.01318 HEXB - Beta-hexosaminidase subunit beta precursor - Felis catus (Cat) - HEXB gene Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). Indicus|evm.model.CM009510.1.69 P49614 HEXB_FELCA 66.148 0.927239 1.00942 HEXB - Beta-hexosaminidase subunit beta precursor - Felis catus (Cat) - HEXB gene Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). Indicus|evm.model.CM009510.1.70 O14682 ENC1_HUMAN 99.660 0.99661 1.0017 ENC1 - Ectoderm-neural cortex protein 1 - Homo sapiens (Human) - ENC1 gene Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism. Indicus|evm.model.CM009510.1.71 Q8N1W1 ARG28_HUMAN 81.641 0.998797 0.97478 ARHGEF28 - Rho guanine nucleotide exchange factor 28 - Homo sapiens (Human) - ARHGEF28 gene Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). Indicus|evm.model.CM009510.1.72 Q93104 ERH_AEDAE 85.106 0.11138 4.00971 Enhancer of rudimentary homolog - Aedes aegypti (Yellowfever mosquito) Indicus|evm.model.CM009510.1.73 A7MB12 UTP15_BOVIN 100.000 0.996154 1.00193 UTP15 - U3 small nucleolar RNA-associated protein 15 homolog - Bos taurus (Bovine) - UTP15 gene Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Indicus|evm.model.CM009510.1.74 Q2KI79 ANRA2_BOVIN 100.000 0.993631 1.00319 ANKRA2 - Ankyrin repeat family A protein 2 - Bos taurus (Bovine) - ANKRA2 gene May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (By similarity). May also regulate LRP2/megalin (By similarity). Indicus|evm.model.CM009510.1.75 Q95339 ATPK_PIG 78.409 0.9 1.02273 ATP5MF - ATP synthase subunit f, mitochondrial - Sus scrofa (Pig) - ATP5MF gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Indicus|evm.model.CM009510.1.76 P20290 BTF3_HUMAN 97.087 0.990338 1.00485 BTF3 - Transcription factor BTF3 - Homo sapiens (Human) - BTF3 gene When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. Indicus|evm.model.CM009510.1.77 P0DP31 CALM3_RAT 98.658 0.986667 1.00671 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Indicus|evm.model.CM009510.1.80 Q8WUU8 TM174_HUMAN 81.780 0.991561 0.975309 TMEM174 - Transmembrane protein 174 - Homo sapiens (Human) - TMEM174 gene Indicus|evm.model.CM009510.1.81 Q58DS4 TM171_BOVIN 99.693 0.993884 1.00307 TMEM171 - Transmembrane protein 171 - Bos taurus (Bovine) - TMEM171 gene Indicus|evm.model.CM009510.1.82 Q0JRZ9 FCHO2_HUMAN 94.111 0.997599 1.0284 FCHO2 - F-BAR domain only protein 2 - Homo sapiens (Human) - FCHO2 gene Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. Indicus|evm.model.CM009510.1.83 Q3SYU7 TNPO1_BOVIN 100.000 0.360262 1.02004 TNPO1 - Transportin-1 - Bos taurus (Bovine) - TNPO1 gene Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. Mediates nuclear import of ADAR/ADAR1 in a RanGTP-dependent manner (By similarity). Indicus|evm.model.CM009510.1.84 Q8WNR4 H2BV_BOVIN 100.000 0.98374 1.0082 SUBH2BV - Histone H2B subacrosomal variant - Bos taurus (Bovine) - SUBH2BV gene May act as an acrosome-nuclear docking protein in sperm. Indicus|evm.model.CM009510.1.86 Q8N895 ZN366_HUMAN 87.399 0.997308 0.998656 ZNF366 - Zinc finger protein 366 - Homo sapiens (Human) - ZNF366 gene Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases. Indicus|evm.model.CM009510.1.87 Q3SZ55 PTCD2_BOVIN 100.000 0.994805 1.0026 PTCD2 - Pentatricopeptide repeat-containing protein 2, mitochondrial - Bos taurus (Bovine) - PTCD2 gene Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function. Indicus|evm.model.CM009510.1.88 Q6WV90 H4_MYTGA 99.029 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009510.1.89 Q32PI8 RT27_BOVIN 98.916 0.986595 0.898795 MRPS27 - 28S ribosomal protein S27, mitochondrial precursor - Bos taurus (Bovine) - MRPS27 gene RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues. Indicus|evm.model.CM009510.1.90 P46821 MAP1B_HUMAN 89.068 0.701299 0.998379 MAP1B - Microtubule-associated protein 1B - Homo sapiens (Human) - MAP1B gene Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. Indicus|evm.model.CM009510.1.92 Q68RJ9 CART_BOVIN 100.000 0.982906 1.00862 CARTPT - Cocaine- and amphetamine-regulated transcript protein precursor - Bos taurus (Bovine) - CARTPT gene Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. Indicus|evm.model.CM009510.1.93 Q3ULD5 MCCB_MOUSE 91.474 0.996454 1.00178 Mccc2 - Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor - Mus musculus (Mouse) - Mccc2 gene Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. Indicus|evm.model.CM009510.1.94 A6H8Y1 BDP1_HUMAN 61.715 0.472655 1.05221 BDP1 - Transcription factor TFIIIB component B'' homolog - Homo sapiens (Human) - BDP1 gene General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. Indicus|evm.model.CM009510.1.95 Q32P76 SERF1_BOVIN 98.361 0.237154 4.08065 SERF1 - Small EDRK-rich factor 1 - Bos taurus (Bovine) - SERF1 gene Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (By similarity). Indicus|evm.model.CM009510.1.96 O18870 SMN_BOVIN 100.000 0.986207 1.01045 SMN1 - Survival motor neuron protein - Bos taurus (Bovine) - SMN1 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). Indicus|evm.model.CM009510.1.97 Q13075 BIRC1_HUMAN 71.590 0.996232 0.94583 NAIP - Baculoviral IAP repeat-containing protein 1 - Homo sapiens (Human) - NAIP gene Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. Indicus|evm.model.CM009510.1.98 Q2TBV5 TF2H2_BOVIN 100.000 0.42015 2.36203 GTF2H2 - General transcription factor IIH subunit 2 - Bos taurus (Bovine) - GTF2H2 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. Indicus|evm.model.CM009510.1.99 Q8N4S9 MALD2_HUMAN 88.869 0.992857 1.00358 MARVELD2 - MARVEL domain-containing protein 2 - Homo sapiens (Human) - MARVELD2 gene Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). Indicus|evm.model.CM009510.1.100 O75943 RAD17_HUMAN 88.873 0.960508 1.04112 RAD17 - Cell cycle checkpoint protein RAD17 - Homo sapiens (Human) - RAD17 gene Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. Indicus|evm.model.CM009510.1.101 A5PJA1 KAD6_BOVIN 99.419 0.988439 1.00581 AK6 - Adenylate kinase isoenzyme 6 - Bos taurus (Bovine) - AK6 gene Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. Indicus|evm.model.CM009510.1.102 Q86Z20 CC125_HUMAN 76.608 0.994163 1.00587 CCDC125 - Coiled-coil domain-containing protein 125 - Homo sapiens (Human) - CCDC125 gene May be involved in the regulation of cell migration. Indicus|evm.model.CM009510.1.103 P51952 CDK7_RAT 96.960 0.945245 1.05471 Cdk7 - Cyclin-dependent kinase 7 - Rattus norvegicus (Rat) - Cdk7 gene Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition (By similarity). Indicus|evm.model.CM009510.1.104 P82908 RT36_BOVIN 100.000 0.980769 1.00971 MRPS36 - 28S ribosomal protein S36, mitochondrial - Bos taurus (Bovine) - MRPS36 gene May be necessary to recruit DLD/E3 to the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDC) core composed of OGDH/E1-DLST/E2, hence stabilizes the complex. Indicus|evm.model.CM009510.1.105 Q3T0L1 CENPH_BOVIN 100.000 0.991837 1.0041 CENPH - Centromere protein H - Bos taurus (Bovine) - CENPH gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Indicus|evm.model.CM009510.1.106 Q1LZG6 CCNB1_BOVIN 99.766 0.343548 2.90398 CCNB1 - G2/mitotic-specific cyclin-B1 - Bos taurus (Bovine) - CCNB1 gene Essential for the control of the cell cycle at the G2/M (mitosis) transition. Indicus|evm.model.CM009510.1.107 P23727 P85A_BOVIN 100.000 0.997241 1.00138 PIK3R1 - Phosphatidylinositol 3-kinase regulatory subunit alpha - Bos taurus (Bovine) - PIK3R1 gene Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). Indicus|evm.model.CM009510.1.110 P63170 DYL1_RAT 100.000 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Indicus|evm.model.CM009510.1.113 Q99467 CD180_HUMAN 78.064 0.996979 1.00151 CD180 - CD180 antigen precursor - Homo sapiens (Human) - CD180 gene May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). Indicus|evm.model.CM009510.1.114 O15021 MAST4_HUMAN 85.435 0.63888 1.15707 MAST4 - Microtubule-associated serine/threonine-protein kinase 4 - Homo sapiens (Human) - MAST4 gene protein serine/threonine kinase activity, cytoskeleton organization, intracellular signal transduction, peptidyl-serine phosphorylation Indicus|evm.model.CM009510.1.116 O15021 MAST4_HUMAN 74.590 0.581633 0.0747236 MAST4 - Microtubule-associated serine/threonine-protein kinase 4 - Homo sapiens (Human) - MAST4 gene protein serine/threonine kinase activity, cytoskeleton organization, intracellular signal transduction, peptidyl-serine phosphorylation Indicus|evm.model.CM009510.1.119 Q8WXA9 SREK1_HUMAN 85.098 0.951311 0.525591 SREK1 - Splicing regulatory glutamine/lysine-rich protein 1 - Homo sapiens (Human) - SREK1 gene Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). Indicus|evm.model.CM009510.1.120 Q8WXA9 SREK1_HUMAN 99.541 0.990868 0.431102 SREK1 - Splicing regulatory glutamine/lysine-rich protein 1 - Homo sapiens (Human) - SREK1 gene Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). Indicus|evm.model.CM009510.1.121 Q96RT1 ERBIN_HUMAN 89.459 0.985811 1.04816 ERBIN - Erbin - Homo sapiens (Human) - ERBIN gene Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728). Indicus|evm.model.CM009510.1.122 A2VDQ5 NEUL_BOVIN 99.625 0.996255 0.758523 NLN - Neurolysin, mitochondrial precursor - Bos taurus (Bovine) - NLN gene Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Indicus|evm.model.CM009510.1.123 A2VDQ5 NEUL_BOVIN 99.213 0.828947 0.215909 NLN - Neurolysin, mitochondrial precursor - Bos taurus (Bovine) - NLN gene Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Indicus|evm.model.CM009510.1.124 Q8VD33 SGTB_MOUSE 83.516 0.544828 1.43092 Sgtb - Small glutamine-rich tetratricopeptide repeat-containing protein beta - Mus musculus (Mouse) - Sgtb gene Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. Indicus|evm.model.CM009510.1.125 A7MB76 TPC13_BOVIN 99.761 0.995227 1.0048 TRAPPC13 - Trafficking protein particle complex subunit 13 - Bos taurus (Bovine) - TRAPPC13 gene TRAPPIII protein complex Indicus|evm.model.CM009510.1.126 Q8BGX0 TRI23_MOUSE 97.909 0.996522 1.00174 Trim23 - E3 ubiquitin-protein ligase TRIM23 - Mus musculus (Mouse) - Trim23 gene Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. Indicus|evm.model.CM009510.1.127 Q29RZ2 PPWD1_BOVIN 99.689 0.996899 1.00155 PPWD1 - Peptidylprolyl isomerase domain and WD repeat-containing protein 1 - Bos taurus (Bovine) - PPWD1 gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing. Indicus|evm.model.CM009510.1.128 Q5XGL1 CENPK_XENLA 69.388 0.231884 0.755474 cenpk - Centromere protein K - Xenopus laevis (African clawed frog) - cenpk gene Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Indicus|evm.model.CM009510.1.129 Q9UKP5 ATS6_HUMAN 98.117 0.995064 0.906893 ADAMTS6 - A disintegrin and metalloproteinase with thrombospondin motifs 6 precursor - Homo sapiens (Human) - ADAMTS6 gene extracellular matrix, metalloendopeptidase activity, metallopeptidase activity, extracellular matrix organization Indicus|evm.model.CM009510.1.130 Q17QX9 CWC27_BOVIN 99.366 0.995781 1.00211 CWC27 - Spliceosome-associated protein CWC27 homolog - Bos taurus (Bovine) - CWC27 gene As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. Indicus|evm.model.CM009510.1.131 Q8N9Q2 SR1IP_HUMAN 95.312 0.396226 1.02581 SREK1IP1 - Protein SREK1IP1 - Homo sapiens (Human) - SREK1IP1 gene Possible splicing regulator involved in the control of cellular survival. Indicus|evm.model.CM009510.1.132 A6QQ93 SHL2B_BOVIN 100.000 0.987654 1.00621 SHISAL2B - Protein shisa-like-2B - Bos taurus (Bovine) - SHISAL2B gene Indicus|evm.model.CM009510.1.133 Q08DH5 R7BP_BOVIN 99.611 0.992248 1.00389 RGS7BP - Regulator of G-protein signaling 7-binding protein - Bos taurus (Bovine) - RGS7BP gene Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. Indicus|evm.model.CM009510.1.134 Q86T96 RN180_HUMAN 85.642 0.996558 0.981419 RNF180 - E3 ubiquitin-protein ligase RNF180 - Homo sapiens (Human) - RNF180 gene E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. Indicus|evm.model.CM009510.1.135 Q0EAB6 5HT1A_HORSE 92.417 0.995272 1.00237 HTR1A - 5-hydroxytryptamine receptor 1A - Equus caballus (Horse) - HTR1A gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli (By similarity). Indicus|evm.model.CM009510.1.137 Q9UI26 IPO11_HUMAN 94.051 0.997886 0.970256 IPO11 - Importin-11 - Homo sapiens (Human) - IPO11 gene Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). Indicus|evm.model.CM009510.1.138 Q2KHT8 DIM1_BOVIN 100.000 0.993631 1.00319 DIMT1 - Probable dimethyladenosine transferase - Bos taurus (Bovine) - DIMT1 gene Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Indicus|evm.model.CM009510.1.139 O00139 KIF2A_HUMAN 99.150 0.997171 1.00142 KIF2A - Kinesin-like protein KIF2A - Homo sapiens (Human) - KIF2A gene Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. Indicus|evm.model.CM009510.1.140 Q99933 BAG1_HUMAN 85.778 0.99115 0.655072 BAG1 - BAG family molecular chaperone regulator 1 - Homo sapiens (Human) - BAG1 gene Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). Indicus|evm.model.CM009510.1.142 Q9HCJ5 ZSWM6_HUMAN 98.888 0.98998 0.821399 ZSWIM6 - Zinc finger SWIM domain-containing protein 6 - Homo sapiens (Human) - ZSWIM6 gene involved in nervous system development, important for striatal morphology and motor regulation. Indicus|evm.model.CM009510.1.143 Q32P65 NDUF2_BOVIN 99.405 0.988166 1.00595 NDUFAF2 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 precursor - Bos taurus (Bovine) - NDUFAF2 gene Acts as a molecular chaperone for mitochondrial complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009510.1.144 Q5BIM8 ERCC8_BOVIN 100.000 0.994975 1.00252 ERCC8 - DNA excision repair protein ERCC-8 - Bos taurus (Bovine) - ERCC8 gene Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (By similarity). The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair (By similarity). It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (By similarity). Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair; involved in repair of DSSBs by non-homologous end joining (NHEJ) (By similarity). Indicus|evm.model.CM009510.1.145 A0JNC4 ELOV7_BOVIN 100.000 0.988235 0.604982 ELOVL7 - Elongation of very long chain fatty acids protein 7 - Bos taurus (Bovine) - ELOVL7 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Indicus|evm.model.CM009510.1.146 Q4R623 DEP1B_MACFA 98.077 0.233032 0.835539 DEPDC1B - DEP domain-containing protein 1B - Macaca fascicularis (Crab-eating macaque) - DEPDC1B gene Indicus|evm.model.CM009510.1.151 Q08499 PDE4D_HUMAN 98.630 0.983483 0.823239 PDE4D - cAMP-specific 3',5'-cyclic phosphodiesterase 4D - Homo sapiens (Human) - PDE4D gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Indicus|evm.model.CM009510.1.152 P10949 RAB3C_BOVIN 100.000 0.990909 0.969163 RAB3C - Ras-related protein Rab-3C - Bos taurus (Bovine) - RAB3C gene Protein transport. Probably involved in vesicular traffic (By similarity). Indicus|evm.model.CM009510.1.153 Q8N292 GAPT_HUMAN 69.620 0.987421 1.01274 GAPT - Protein GAPT - Homo sapiens (Human) - GAPT gene Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity). Indicus|evm.model.CM009510.1.154 Q9NYY3 PLK2_HUMAN 97.956 0.997085 1.00146 PLK2 - Serine/threonine-protein kinase PLK2 - Homo sapiens (Human) - PLK2 gene Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. Indicus|evm.model.CM009510.1.155 Q8BFZ3 ACTBL_MOUSE 96.543 0.994695 1.00266 Actbl2 - Beta-actin-like protein 2 - Mus musculus (Mouse) - Actbl2 gene Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Indicus|evm.model.CM009510.1.156 P13668 STMN1_RAT 89.933 0.985915 0.95302 Stmn1 - Stathmin - Rattus norvegicus (Rat) - Stmn1 gene Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). Indicus|evm.model.CM009510.1.157 Q0P5K1 GPBP1_BOVIN 95.740 0.995951 1.0444 GPBP1 - Vasculin - Bos taurus (Bovine) - GPBP1 gene Functions as a GC-rich promoter-specific transactivating transcription factor. Indicus|evm.model.CM009510.1.158 P62246 RS15A_RAT 92.308 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Indicus|evm.model.CM009510.1.159 Q4R3R9 MIER3_MACFA 97.774 0.988971 0.989091 MIER3 - Mesoderm induction early response protein 3 - Macaca fascicularis (Crab-eating macaque) - MIER3 gene Transcriptional repressor. Indicus|evm.model.CM009510.1.160 Q8NE22 SETD9_HUMAN 91.973 0.993333 1.00334 SETD9 - SET domain-containing protein 9 - Homo sapiens (Human) - SETD9 gene nucleoplasm, regulation of signal transduction by p53 class mediator Indicus|evm.model.CM009510.1.161 Q13233 M3K1_HUMAN 94.231 0.893165 0.996693 MAP3K1 - Mitogen-activated protein kinase kinase kinase 1 - Homo sapiens (Human) - MAP3K1 gene Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). Indicus|evm.model.CM009510.1.163 Q3KP44 ANR55_HUMAN 89.394 0.996633 0.967427 ANKRD55 - Ankyrin repeat domain-containing protein 55 - Homo sapiens (Human) - ANKRD55 gene Indicus|evm.model.CM009510.1.164 P40189 IL6RB_HUMAN 87.486 0.997824 1.00109 IL6ST - Interleukin-6 receptor subunit beta precursor - Homo sapiens (Human) - IL6ST gene Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activate the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:2261637, PubMed:19915009, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). Indicus|evm.model.CM009510.1.165 Q5W5U4 DDX4_BOVIN 99.715 0.497516 1.93278 DDX4 - Probable ATP-dependent RNA helicase DDX4 - Bos taurus (Bovine) - DDX4 gene ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs. Indicus|evm.model.CM009510.1.166 Q8NBW4 S38A9_HUMAN 91.087 0.996441 1.00178 SLC38A9 - Sodium-coupled neutral amino acid transporter 9 - Homo sapiens (Human) - SLC38A9 gene Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906, PubMed:29053970). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids (PubMed:25561175, PubMed:25567906). Acts as an arginine sensor (PubMed:25567906, PubMed:29053970). Following activation by arginine binding, mediates transport of leucine, tyrosine and phenylalanine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation (PubMed:29053970). Indicus|evm.model.CM009510.1.167 P60588 PLPP1_PIG 97.895 0.993007 1.00351 PLPP1 - Phospholipid phosphatase 1 - Sus scrofa (Pig) - PLPP1 gene Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (Ref.1, PubMed:8702556, PubMed:1334090). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (By similarity). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (By similarity). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (By similarity). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity). Indicus|evm.model.CM009510.1.168 P42285 MTREX_HUMAN 91.887 0.832849 0.660269 MTREX - Exosome RNA helicase MTR4 - Homo sapiens (Human) - MTREX gene Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension (PubMed:27871484, PubMed:29844170, PubMed:29906447). Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) (PubMed:27871484, PubMed:29844170, PubMed:21855801). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484, PubMed:29844170). PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand (PubMed:29844170). Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (PubMed:29906447). Plays a role in DNA damage response (PubMed:29902117). Indicus|evm.model.CM009510.1.169 Q7Z478 DHX29_HUMAN 93.864 0.997805 0.998539 DHX29 - ATP-dependent RNA helicase DHX29 - Homo sapiens (Human) - DHX29 gene ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. Indicus|evm.model.CM009510.1.170 P22674 CCNO_HUMAN 86.969 0.821596 1.21714 CCNO - Cyclin-O - Homo sapiens (Human) - CCNO gene Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking. Indicus|evm.model.CM009510.1.171 G3N1S4 MCIN_BOVIN 99.733 0.994667 1.00267 MCIDAS - Multicilin - Bos taurus (Bovine) - MCIDAS gene Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1. Indicus|evm.model.CM009510.1.172 Q2NL01 GPX8_BOVIN 100.000 0.990476 1.00478 GPX8 - Probable glutathione peroxidase 8 - Bos taurus (Bovine) - GPX8 gene peroxidase activity Indicus|evm.model.CM009510.1.173 P12544 GRAA_HUMAN 70.992 0.992308 0.992366 GZMA - Granzyme A precursor - Homo sapiens (Human) - GZMA gene Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3257574, PubMed:3262682, PubMed:3263427, PubMed:32299851, PubMed:12819770). It cleaves after Lys or Arg (PubMed:32299851, PubMed:12819770). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death (PubMed:32299851). Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity (PubMed:12524539). Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (PubMed:11555662, PubMed:12628186, PubMed:16818237). Indicus|evm.model.CM009510.1.174 Q7YRZ7 GRAA_BOVIN 99.574 0.860294 1.05426 GZMA - Granzyme A precursor - Bos taurus (Bovine) - GZMA gene Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Indicus|evm.model.CM009510.1.175 P49863 GRAK_HUMAN 72.917 0.991701 0.912879 GZMK - Granzyme K precursor - Homo sapiens (Human) - GZMK gene serine-type peptidase activity Indicus|evm.model.CM009510.1.176 Q9NQ30 ESM1_HUMAN 80.000 0.989189 1.00543 ESM1 - Endothelial cell-specific molecule 1 precursor - Homo sapiens (Human) - ESM1 gene Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions. Indicus|evm.model.CM009510.1.178 P14622 COX8A_BOVIN 97.101 0.971429 1.01449 COX8A - Cytochrome c oxidase subunit 8A, mitochondrial precursor - Bos taurus (Bovine) - COX8A gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009510.1.179 Q32LC7 G3BP1_BOVIN 93.525 0.985714 0.301075 G3BP1 - Ras GTPase-activating protein-binding protein 1 - Bos taurus (Bovine) - G3BP1 gene ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. Indicus|evm.model.CM009510.1.180 Q96RF0 SNX18_HUMAN 96.709 0.99635 0.872611 SNX18 - Sorting nexin-18 - Homo sapiens (Human) - SNX18 gene Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. Indicus|evm.model.CM009510.1.181 Q2KHU9 HSPB3_BOVIN 100.000 0.986667 1.00671 HSPB3 - Heat shock protein beta-3 - Bos taurus (Bovine) - HSPB3 gene Inhibitor of actin polymerization. Indicus|evm.model.CM009510.1.182 Q5EA19 ARL15_BOVIN 99.020 0.990244 1.01485 ARL15 - ADP-ribosylation factor-like protein 15 - Bos taurus (Bovine) - ARL15 gene Indicus|evm.model.CM009510.1.184 P50291 FST_BOVIN 100.000 0.994203 1.00291 FST - Follistatin precursor - Bos taurus (Bovine) - FST gene Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). Indicus|evm.model.CM009510.1.185 P24049 RL17_RAT 81.522 0.988024 0.907609 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009510.1.186 A4FUY7 MOC2B_BOVIN 98.148 0.657143 1.2963 MOCS2 - Molybdopterin synthase catalytic subunit - Bos taurus (Bovine) - MOCS2 gene Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. Indicus|evm.model.CM009510.1.187 P53710 ITA2_BOVIN 99.829 0.990678 1.00855 ITGA2 - Integrin alpha-2 precursor - Bos taurus (Bovine) - ITGA2 gene Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Indicus|evm.model.CM009510.1.188 P56199 ITA1_HUMAN 91.017 0.998305 1.00085 ITGA1 - Integrin alpha-1 precursor - Homo sapiens (Human) - ITGA1 gene Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Indicus|evm.model.CM009510.1.189 P61374 ISL1_RAT 100.000 0.994286 1.00287 Isl1 - Insulin gene enhancer protein ISL-1 - Rattus norvegicus (Rat) - Isl1 gene DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequences (PubMed:1691825). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity). Indicus|evm.model.CM009510.1.192 Q8N3A8 PARP8_HUMAN 97.541 0.893194 1.11827 PARP8 - Protein mono-ADP-ribosyltransferase PARP8 - Homo sapiens (Human) - PARP8 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Indicus|evm.model.CM009510.1.193 Q6PCB8 EMB_HUMAN 72.297 0.75641 1.19266 EMB - Embigin precursor - Homo sapiens (Human) - EMB gene Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). Indicus|evm.model.CM009510.1.195 Q3SZP8 TAD2A_BOVIN 82.812 0.933333 0.30474 TADA2A - Transcriptional adapter 2-alpha - Bos taurus (Bovine) - TADA2A gene Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. Indicus|evm.model.CM009510.1.196 Q9MZS1 HCN1_RABIT 98.413 0.3875 0.194647 HCN1 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 - Oryctolagus cuniculus (Rabbit) - HCN1 gene Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. Indicus|evm.model.CM009510.1.197 O88704 HCN1_MOUSE 98.861 0.732441 0.657143 Hcn1 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 - Mus musculus (Mouse) - Hcn1 gene Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. Indicus|evm.model.CM009510.1.200 P82924 RT30_BOVIN 100.000 0.995413 1.0023 MRPS30 - 28S ribosomal protein S30, mitochondrial - Bos taurus (Bovine) - MRPS30 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Indicus|evm.model.CM009510.1.201 Q3SZB5 CC115_BOVIN 96.970 0.984962 0.738889 CCDC115 - Coiled-coil domain-containing protein 115 - Bos taurus (Bovine) - CCDC115 gene Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity). Indicus|evm.model.CM009510.1.202 P70492 FGF10_RAT 93.913 0.965517 0.539535 Fgf10 - Fibroblast growth factor 10 precursor - Rattus norvegicus (Rat) - Fgf10 gene Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Indicus|evm.model.CM009510.1.203 P70492 FGF10_RAT 100.000 0.809917 0.562791 Fgf10 - Fibroblast growth factor 10 precursor - Rattus norvegicus (Rat) - Fgf10 gene Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Indicus|evm.model.CM009510.1.204 Q5R893 H2B1_PONAB 90.476 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009510.1.205 P11024 NNTM_BOVIN 99.908 0.99816 1.00092 NNT - NAD(P) transhydrogenase, mitochondrial precursor - Bos taurus (Bovine) - NNT gene The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity). Indicus|evm.model.CM009510.1.206 Q8VE62 PAIP1_MOUSE 96.429 0.807851 1.21 Paip1 - Polyadenylate-binding protein-interacting protein 1 - Mus musculus (Mouse) - Paip1 gene Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Indicus|evm.model.CM009510.1.207 A4FUB0 CE034_BOVIN 100.000 0.99687 1.00157 Uncharacterized protein C5orf34 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009510.1.208 Q17QJ2 TM267_BOVIN 100.000 0.990741 1.00465 TMEM267 - Transmembrane protein 267 - Bos taurus (Bovine) - TMEM267 gene Indicus|evm.model.CM009510.1.209 Q68A91 CCL28_CANLF 79.845 0.969231 1.01562 CCL28 - C-C motif chemokine 28 precursor - Canis lupus familiaris (Dog) - CCL28 gene Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner (By similarity). Indicus|evm.model.CM009510.1.210 Q01581 HMCS1_HUMAN 95.962 0.925134 1.07885 HMGCS1 - Hydroxymethylglutaryl-CoA synthase, cytoplasmic - Homo sapiens (Human) - HMGCS1 gene Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. Indicus|evm.model.CM009510.1.211 Q8IY84 NIM1_HUMAN 94.266 0.995423 1.00229 NIM1K - Serine/threonine-protein kinase NIM1 - Homo sapiens (Human) - NIM1K gene cytoplasm, nucleus, ATP binding, magnesium ion binding, protein serine/threonine kinase activity, cellular response to glucose starvation, intracellular signal transduction, protein phosphorylation Indicus|evm.model.CM009510.1.212 Q5RAU9 ZN131_PONAB 95.064 0.859519 0.918506 ZNF131 - Zinc finger protein 131 - Pongo abelii (Sumatran orangutan) - ZNF131 gene May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). Indicus|evm.model.CM009510.1.213 Q5RAU9 ZN131_PONAB 84.416 0.980769 0.264856 ZNF131 - Zinc finger protein 131 - Pongo abelii (Sumatran orangutan) - ZNF131 gene May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). Indicus|evm.model.CM009510.1.215 A6QM04 ZWILC_BOVIN 99.156 0.473896 0.845501 ZWILCH - Protein zwilch homolog - Bos taurus (Bovine) - ZWILCH gene Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity). Indicus|evm.model.CM009510.1.220 P79103 RS4_BOVIN 84.791 0.991453 0.889734 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009510.1.221 Q02543 RL18A_HUMAN 82.727 0.981818 0.625 RPL18A - 60S ribosomal protein L18a - Homo sapiens (Human) - RPL18A gene cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing Indicus|evm.model.CM009510.1.222 P49908 SEPP1_HUMAN 88.991 0.635294 0.446194 SELENOP - Selenoprotein P precursor - Homo sapiens (Human) - SELENOP gene Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis. Indicus|evm.model.CM009510.1.223 Q32LM7 CC152_BOVIN 90.875 0.992424 1.1 CCDC152 - Coiled-coil domain-containing protein 152 - Bos taurus (Bovine) - CCDC152 gene Indicus|evm.model.CM009510.1.224 O46600 GHR_BOVIN 99.527 0.99685 1.00158 GHR - Growth hormone receptor precursor - Bos taurus (Bovine) - GHR gene Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). Indicus|evm.model.CM009510.1.226 Q3T0J1 FBX4_BOVIN 100.000 0.994845 1.00258 FBXO4 - F-box only protein 4 - Bos taurus (Bovine) - FBXO4 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). Indicus|evm.model.CM009510.1.227 A6NDU8 CE051_HUMAN 90.816 0.993197 1 C5orf51 - UPF0600 protein C5orf51 - Homo sapiens (Human) - C5orf51 gene cytosol, nucleoplasm Indicus|evm.model.CM009510.1.228 Q29551 SCOT1_PIG 94.595 0.207977 0.675 OXCT1 - Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor - Sus scrofa (Pig) - OXCT1 gene Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. Indicus|evm.model.CM009510.1.229 Q8BLJ3 PLCX3_MOUSE 92.105 0.385417 0.299065 Plcxd3 - PI-PLC X domain-containing protein 3 - Mus musculus (Mouse) - Plcxd3 gene glutamatergic synapse, synapse Indicus|evm.model.CM009510.1.230 Q63HM9 PLCX3_HUMAN 99.652 0.972789 0.915888 PLCXD3 - PI-PLC X domain-containing protein 3 - Homo sapiens (Human) - PLCXD3 gene Indicus|evm.model.CM009510.1.231 Q29RU4 CO6_BOVIN 99.142 0.997856 1.00107 C6 - Complement component C6 precursor - Bos taurus (Bovine) - C6 gene Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Indicus|evm.model.CM009510.1.232 Q7Z745 MRO2B_HUMAN 85.624 0.99874 1.00126 MROH2B - Maestro heat-like repeat-containing protein family member 2B - Homo sapiens (Human) - MROH2B gene May play a role in the process of sperm capacitation. Indicus|evm.model.CM009510.1.233 Q29RQ1 CO7_BOVIN 99.288 0.99763 1.00119 C7 - Complement component C7 precursor - Bos taurus (Bovine) - C7 gene Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor (By similarity). Indicus|evm.model.CM009510.1.234 Q9BX69 CARD6_HUMAN 68.708 0.998069 0.999036 CARD6 - Caspase recruitment domain-containing protein 6 - Homo sapiens (Human) - CARD6 gene May be involved in apoptosis. Indicus|evm.model.CM009510.1.235 P61928 RL37_RAT 100.000 0.979592 1.01031 Rpl37 - 60S ribosomal protein L37 - Rattus norvegicus (Rat) - Rpl37 gene Binds to the 23S rRNA. Indicus|evm.model.CM009510.1.236 Q13131 AAPK1_HUMAN 99.273 0.99637 0.985689 PRKAA1 - 5'-AMP-activated protein kinase catalytic subunit alpha-1 - Homo sapiens (Human) - PRKAA1 gene Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. In that process also activates WDR45 (PubMed:28561066). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1. Indicus|evm.model.CM009510.1.237 Q6PID6 TTC33_HUMAN 93.893 0.992395 1.00382 TTC33 - Tetratricopeptide repeat protein 33 - Homo sapiens (Human) - TTC33 gene Indicus|evm.model.CM009510.1.238 Q8MJ08 PE2R4_BOVIN 99.187 0.995943 1.00203 PTGER4 - Prostaglandin E2 receptor EP4 subtype - Bos taurus (Bovine) - PTGER4 gene Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity). Indicus|evm.model.CM009510.1.242 P98082 DAB2_HUMAN 86.364 0.997399 0.998701 DAB2 - Disabled homolog 2 - Homo sapiens (Human) - DAB2 gene Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. Indicus|evm.model.CM009510.1.243 Q3MHN2 CO9_BOVIN 99.453 0.996357 1.00182 C9 - Complement component C9 precursor - Bos taurus (Bovine) - C9 gene Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. Indicus|evm.model.CM009510.1.244 O15117 FYB1_HUMAN 79.873 0.923077 1.07918 FYB1 - FYN-binding protein 1 - Homo sapiens (Human) - FYB1 gene Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). Indicus|evm.model.CM009510.1.245 Q6R327 RICTR_HUMAN 97.892 0.99883 1.00059 RICTOR - Rapamycin-insensitive companion of mTOR - Homo sapiens (Human) - RICTOR gene Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. Indicus|evm.model.CM009510.1.246 Q99650 OSMR_HUMAN 69.082 0.995893 0.994893 OSMR - Oncostatin-M-specific receptor subunit beta precursor - Homo sapiens (Human) - OSMR gene Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Indicus|evm.model.CM009510.1.247 A3KN33 EGFLA_BOVIN 98.305 0.0953545 1.2053 EGFLAM - Pikachurin precursor - Bos taurus (Bovine) - EGFLAM gene Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity). Indicus|evm.model.CM009510.1.249 P39905 GDNF_HUMAN 83.264 0.991667 1.13744 GDNF - Glial cell line-derived neurotrophic factor precursor - Homo sapiens (Human) - GDNF gene Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Indicus|evm.model.CM009510.1.250 Q32LB0 WDR70_BOVIN 99.847 0.996937 1.00153 WDR70 - WD repeat-containing protein 70 - Bos taurus (Bovine) - WDR70 gene Indicus|evm.model.CM009510.1.251 O75694 NU155_HUMAN 96.454 0.998554 0.994249 NUP155 - Nuclear pore complex protein Nup155 - Homo sapiens (Human) - NUP155 gene Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Indicus|evm.model.CM009510.1.252 Q9H799 CPLN1_HUMAN 74.651 0.999387 1.02033 CPLANE1 - Ciliogenesis and planar polarity effector 1 - Homo sapiens (Human) - CPLANE1 gene Involved in ciliogenesis (PubMed:25877302). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). Indicus|evm.model.CM009510.1.253 Q6KC79 NIPBL_HUMAN 97.646 0.999287 1.00036 NIPBL - Nipped-B-like protein - Homo sapiens (Human) - NIPBL gene Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). Indicus|evm.model.CM009510.1.254 A6QLR3 ABRX2_BOVIN 98.746 0.848 0.91687 ABRAXAS2 - BRISC complex subunit Abraxas 2 - Bos taurus (Bovine) - ABRAXAS2 gene Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (By similarity). Indicus|evm.model.CM009510.1.255 P46411 EAA1_BOVIN 99.815 0.996317 1.00185 SLC1A3 - Excitatory amino acid transporter 1 - Bos taurus (Bovine) - SLC1A3 gene Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7723632). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Indicus|evm.model.CM009510.1.256 Q3SZ63 NOP56_BOVIN 52.500 0.854167 0.241611 NOP56 - Nucleolar protein 56 - Bos taurus (Bovine) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Indicus|evm.model.CM009510.1.258 Q86VV4 RNB3L_HUMAN 75.534 0.841683 1.07312 RANBP3L - Ran-binding protein 3-like - Homo sapiens (Human) - RANBP3L gene Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner. Indicus|evm.model.CM009510.1.259 Q4G0N4 NAKD2_HUMAN 91.164 0.995699 1.05204 NADK2 - NAD kinase 2, mitochondrial precursor - Homo sapiens (Human) - NADK2 gene Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. Indicus|evm.model.CM009510.1.260 Q13309 SKP2_HUMAN 90.566 0.967963 1.03066 SKP2 - S-phase kinase-associated protein 2 - Homo sapiens (Human) - SKP2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Indicus|evm.model.CM009510.1.261 Q68DH5 LMBD2_HUMAN 95.827 0.997126 1.00144 LMBRD2 - G-protein coupled receptor-associated protein LMBRD2 - Homo sapiens (Human) - LMBRD2 gene Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway (PubMed:28388415). May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable). Indicus|evm.model.CM009510.1.262 Q1LZI1 UD3A1_BOVIN 100.000 0.996183 1.00191 UGT3A1 - UDP-glucuronosyltransferase 3A1 precursor - Bos taurus (Bovine) - UGT3A1 gene UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). Indicus|evm.model.CM009510.1.263 Q1LZI1 UD3A1_BOVIN 69.216 0.995918 0.936902 UGT3A1 - UDP-glucuronosyltransferase 3A1 precursor - Bos taurus (Bovine) - UGT3A1 gene UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). Indicus|evm.model.CM009510.1.264 Q8WWF8 CAPSL_HUMAN 96.635 0.990431 1.00481 CAPSL - Calcyphosin-like protein - Homo sapiens (Human) - CAPSL gene Indicus|evm.model.CM009510.1.265 A0MSX9 IL7RA_HORSE 77.778 0.995652 1.00437 IL7R - Interleukin-7 receptor subunit alpha precursor - Equus caballus (Horse) - IL7R gene Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP) (By similarity). Indicus|evm.model.CM009510.1.266 Q2IA00 SPEF2_PIG 83.215 0.998872 0.978477 SPEF2 - Sperm flagellar protein 2 - Sus scrofa (Pig) - SPEF2 gene Required for correct axoneme development in spermatozoa (PubMed:16549801, PubMed:19889948). Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation (By similarity). Indicus|evm.model.CM009510.1.269 Q28172 PRLR_BOVIN 99.312 0.996564 1.00172 PRLR - Prolactin receptor precursor - Bos taurus (Bovine) - PRLR gene This is a receptor for the anterior pituitary hormone prolactin. Indicus|evm.model.CM009510.1.270 Q17QF0 AGT2_BOVIN 100.000 0.996117 1.00195 AGXT2 - Alanine--glyoxylate aminotransferase 2, mitochondrial precursor - Bos taurus (Bovine) - AGXT2 gene Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity). Indicus|evm.model.CM009510.1.271 Q0II91 DJC21_BOVIN 100.000 0.996255 1.00188 DNAJC21 - DnaJ homolog subfamily C member 21 - Bos taurus (Bovine) - DNAJC21 gene May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. Indicus|evm.model.CM009510.1.272 Q3SZZ0 BRX1_BOVIN 99.717 0.99435 1.00283 BRIX1 - Ribosome biogenesis protein BRX1 homolog - Bos taurus (Bovine) - BRIX1 gene Required for biogenesis of the 60S ribosomal subunit. Indicus|evm.model.CM009510.1.273 Q5R7X9 RAD1_PONAB 96.071 0.992857 0.992908 RAD1 - Cell cycle checkpoint protein RAD1 - Pongo abelii (Sumatran orangutan) - RAD1 gene Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Possesses 3'->5' double-stranded DNA exonuclease activity (By similarity). Indicus|evm.model.CM009510.1.274 A6H7D1 TT23L_BOVIN 80.198 0.673378 1.41905 TTC23L - Tetratricopeptide repeat protein 23-like - Bos taurus (Bovine) - TTC23L gene Indicus|evm.model.CM009510.1.275 Q9P0K7 RAI14_HUMAN 92.449 0.997961 1.00102 RAI14 - Ankycorbin - Homo sapiens (Human) - RAI14 gene Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. Indicus|evm.model.CM009510.1.277 O00370 LORF2_HUMAN 72.852 0.935897 0.428235 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Indicus|evm.model.CM009510.1.278 Q9BXJ4 C1QT3_HUMAN 98.630 0.68125 1.30081 C1QTNF3 - Complement C1q tumor necrosis factor-related protein 3 precursor - Homo sapiens (Human) - C1QTNF3 gene extracellular exosome, membrane, identical protein binding, cellular triglyceride homeostasis, fat cell differentiation, negative regulation of gene expression, negative regulation of gluconeogenesis, negative regulation of inflammatory response, negative regulation of interleukin-6 production, negative regulation of monocyte chemotactic protein-1 production Indicus|evm.model.CM009510.1.279 Q9UHK6 AMACR_HUMAN 84.031 0.994778 1.00262 AMACR - Alpha-methylacyl-CoA racemase - Homo sapiens (Human) - AMACR gene Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). Indicus|evm.model.CM009510.1.280 P58355 S45A2_MOUSE 81.538 0.274468 0.886792 Slc45a2 - Membrane-associated transporter protein - Mus musculus (Mouse) - Slc45a2 gene Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity). Indicus|evm.model.CM009510.1.281 Q9NSD7 RL3R1_HUMAN 89.956 0.995643 0.978678 RXFP3 - Relaxin-3 receptor 1 - Homo sapiens (Human) - RXFP3 gene Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation. Indicus|evm.model.CM009510.1.283 P58397 ATS12_HUMAN 82.317 0.88587 0.115433 ADAMTS12 - A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor - Homo sapiens (Human) - ADAMTS12 gene Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. Indicus|evm.model.CM009510.1.284 Q6XXL8 DYLT3_SHEEP 96.552 0.982906 1.00862 DYNLT3 - Dynein light chain Tctex-type 3 - Ovis aries (Sheep) - DYNLT3 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity). Indicus|evm.model.CM009510.1.285 P58397 ATS12_HUMAN 71.589 0.9861 0.767252 ADAMTS12 - A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor - Homo sapiens (Human) - ADAMTS12 gene Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. Indicus|evm.model.CM009510.1.286 Q3ZBV8 SYTC_BOVIN 100.000 0.997238 1.00138 TARS1 - Threonine--tRNA ligase 1, cytoplasmic - Bos taurus (Bovine) - TARS1 gene Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage. Indicus|evm.model.CM009510.1.287 P10730 ANPRC_BOVIN 99.441 0.996276 1 NPR3 - Atrial natriuretic peptide receptor 3 precursor - Bos taurus (Bovine) - NPR3 gene Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. Indicus|evm.model.CM009510.1.288 Q5R6D0 TCP4_PONAB 99.213 0.984375 1.00787 SUB1 - Activated RNA polymerase II transcriptional coactivator p15 - Pongo abelii (Sumatran orangutan) - SUB1 gene General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity). Indicus|evm.model.CM009510.1.290 Q96KR1 ZFR_HUMAN 98.541 0.992263 0.962756 ZFR - Zinc finger RNA-binding protein - Homo sapiens (Human) - ZFR gene Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). Indicus|evm.model.CM009510.1.291 Q9C0I1 MTMRC_HUMAN 89.524 0.944659 1.04016 MTMR12 - Myotubularin-related protein 12 - Homo sapiens (Human) - MTMR12 gene Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity). Indicus|evm.model.CM009510.1.292 P32394 HMOX1_PIG 48.333 0.856061 0.458333 HMOX1 - Heme oxygenase 1 - Sus scrofa (Pig) - HMOX1 gene Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. Indicus|evm.model.CM009510.1.293 Q9ERE4 GOLP3_RAT 97.987 0.993311 1.00336 Golph3 - Golgi phosphoprotein 3 - Rattus norvegicus (Rat) - Golph3 gene Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. Indicus|evm.model.CM009510.1.294 O15018 PDZD2_HUMAN 67.784 0.983072 0.853117 PDZD2 - PDZ domain-containing protein 2 - Homo sapiens (Human) - PDZD2 gene cell-cell junction, centriolar satellite, cytoplasm, cytosol, endoplasmic reticulum, extracellular region, intracellular membrane-bounded organelle, nucleus, plasma membrane Indicus|evm.model.CM009510.1.295 O15018 PDZD2_HUMAN 90.107 0.994667 0.132089 PDZD2 - PDZ domain-containing protein 2 - Homo sapiens (Human) - PDZD2 gene cell-cell junction, centriolar satellite, cytoplasm, cytosol, endoplasmic reticulum, extracellular region, intracellular membrane-bounded organelle, nucleus, plasma membrane Indicus|evm.model.CM009510.1.296 Q9CRA5 GOLP3_MOUSE 96.454 0.915033 0.513423 Golph3 - Golgi phosphoprotein 3 - Mus musculus (Mouse) - Golph3 gene Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis (By similarity). Indicus|evm.model.CM009510.1.297 Q49AR2 CE022_HUMAN 86.818 0.988739 1.00452 C5orf22 - UPF0489 protein C5orf22 - Homo sapiens (Human) - C5orf22 gene Indicus|evm.model.CM009510.1.298 Q9NRR4 RNC_HUMAN 94.836 0.998506 0.974527 DROSHA - Ribonuclease 3 - Homo sapiens (Human) - DROSHA gene Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Indicus|evm.model.CM009510.1.299 Q3SWX5 CADH6_BOVIN 100.000 0.418994 0.226582 CDH6 - Cadherin-6 precursor - Bos taurus (Bovine) - CDH6 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). Indicus|evm.model.CM009510.1.300 Q13813 SPTN1_HUMAN 94.643 0.956897 0.0469256 SPTAN1 - Spectrin alpha chain, non-erythrocytic 1 - Homo sapiens (Human) - SPTAN1 gene Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Indicus|evm.model.CM009510.1.301 Q5R893 H2B1_PONAB 89.381 0.982456 0.904762 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009510.1.302 Q641Z6 EHD1_RAT 61.111 0.297753 0.333333 Ehd1 - EH domain-containing protein 1 - Rattus norvegicus (Rat) - Ehd1 gene ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (By similarity). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (By similarity). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (PubMed:23572513). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (By similarity). Indicus|evm.model.CM009510.1.303 Q5E947 PRDX1_BOVIN 93.617 0.775 0.603015 PRDX1 - Peroxiredoxin-1 - Bos taurus (Bovine) - PRDX1 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). Indicus|evm.model.CM009510.1.304 Q9ULB4 CADH9_HUMAN 95.806 0.985669 0.795944 CDH9 - Cadherin-9 precursor - Homo sapiens (Human) - CDH9 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009510.1.305 Q9Y6N8 CAD10_HUMAN 98.350 0.997465 1.00127 CDH10 - Cadherin-10 precursor - Homo sapiens (Human) - CDH10 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009510.1.306 O02751 CFDP2_BOVIN 68.033 0.235867 0.866554 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Indicus|evm.model.CM009510.1.307 Q08E20 ESTD_BOVIN 88.506 0.634328 0.475177 ESD - S-formylglutathione hydrolase - Bos taurus (Bovine) - ESD gene Serine hydrolase involved in the detoxification of formaldehyde. Indicus|evm.model.CM009510.1.308 P55289 CAD12_HUMAN 95.549 0.994342 0.890428 CDH12 - Cadherin-12 precursor - Homo sapiens (Human) - CDH12 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009510.1.309 A4FUH0 RL22L_BOVIN 86.486 0.894309 1.0082 RPL22L1 - 60S ribosomal protein L22-like 1 - Bos taurus (Bovine) - RPL22L1 gene RNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009510.1.310 Q08DJ5 CAD18_BOVIN 99.747 0.997472 1.00127 CDH18 - Cadherin-18 precursor - Bos taurus (Bovine) - CDH18 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). Indicus|evm.model.CM009510.1.312 Q9N0X0 AURKB_PIG 58.537 0.79 0.290698 AURKB - Aurora kinase B - Sus scrofa (Pig) - AURKB gene Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Indicus|evm.model.CM009510.1.313 Q9Y597 KCTD3_HUMAN 89.048 0.889362 0.288344 KCTD3 - BTB/POZ domain-containing protein KCTD3 - Homo sapiens (Human) - KCTD3 gene Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. Indicus|evm.model.CM009510.1.314 Q9H6Y7 RN167_HUMAN 75.075 0.937853 1.01143 RNF167 - E3 ubiquitin-protein ligase RNF167 precursor - Homo sapiens (Human) - RNF167 gene May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition. Indicus|evm.model.CM009510.1.315 A6NLC8 YE016_HUMAN 57.558 0.818182 1.05556 Putative TAF11-like protein ENSP00000332601 - Homo sapiens (Human) Indicus|evm.model.CM009510.1.316 P62909 RS3_RAT 47.396 0.985915 0.584362 Rps3 - 40S ribosomal protein S3 - Rattus norvegicus (Rat) - Rps3 gene Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). Stimulates the N-glycosylase activity of the base excision protein OGG1 (By similarity). Enhances the uracil excision activity of UNG1 (By similarity). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (By similarity). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (By similarity). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (By similarity). Represses its own translation by binding to its cognate mRNA (By similarity). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (By similarity). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (By similarity). Involved in induction of apoptosis through its role in activation of CASP8 (By similarity). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (By similarity). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (By similarity). Indicus|evm.model.CM009510.1.317 P80724 BASP1_BOVIN 100.000 0.991228 1.00441 BASP1 - Brain acid soluble protein 1 - Bos taurus (Bovine) - BASP1 gene cytoplasm, nuclear speck, nucleus, transcription corepressor activity, transcription regulatory region sequence-specific DNA binding, negative regulation of transcription, DNA-templated Indicus|evm.model.CM009510.1.319 P79114 MYO10_BOVIN 99.903 0.999026 1.00049 MYO10 - Unconventional myosin-X - Bos taurus (Bovine) - MYO10 gene In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation (By similarity). Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate, which are then moved relative to actin filaments. Stimulates the formation and elongation of filopodia. Regulates cell shape, cell spreading and cell adhesion. Plays a role in formation of the podosome belt in osteoclasts. Indicus|evm.model.CM009510.1.320 Q5E9K8 RETR1_BOVIN 100.000 0.994681 0.762677 RETREG1 - Reticulophagy regulator 1 - Bos taurus (Bovine) - RETREG1 gene Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons. Indicus|evm.model.CM009510.1.321 Q969S3 ZN622_HUMAN 82.600 0.925049 1.06289 ZNF622 - Zinc finger protein 622 - Homo sapiens (Human) - ZNF622 gene May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development. Indicus|evm.model.CM009510.1.322 A6NNE9 MARHB_HUMAN 99.057 0.621302 0.420398 MARCHF11 - E3 ubiquitin-protein ligase MARCHF11 - Homo sapiens (Human) - MARCHF11 gene E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids. Indicus|evm.model.CM009510.1.323 Q9UJT9 FBXL7_HUMAN 97.699 0.995825 0.97556 FBXL7 - F-box/LRR-repeat protein 7 - Homo sapiens (Human) - FBXL7 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:25778398). During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398, PubMed:28218735). Indicus|evm.model.CM009510.1.324 Q5RD81 GHC1_PONAB 88.350 0.573034 0.551084 SLC25A22 - Mitochondrial glutamate carrier 1 - Pongo abelii (Sumatran orangutan) - SLC25A22 gene Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+) (By similarity). Indicus|evm.model.CM009510.1.325 Q9HCJ1 ANKH_HUMAN 97.222 0.983158 0.965447 ANKH - Progressive ankylosis protein homolog - Homo sapiens (Human) - ANKH gene Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. Indicus|evm.model.CM009510.1.326 Q96BN8 OTUL_HUMAN 88.636 0.994334 1.00284 OTULIN - Ubiquitin thioesterase otulin - Homo sapiens (Human) - OTULIN gene Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:26997266, PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327, PubMed:28919039). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling (PubMed:23806334). Indicus|evm.model.CM009510.1.327 Q9NUU6 OTULL_HUMAN 93.103 0.993127 0.817416 OTULINL - Inactive ubiquitin thioesterase OTULINL - Homo sapiens (Human) - OTULINL gene Lacks deubiquitinase activity. Indicus|evm.model.CM009510.1.328 F1M0Z1 TRIO_RAT 97.493 0.126551 0.91 Trio - Triple functional domain protein - Rattus norvegicus (Rat) - Trio gene Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth (By similarity). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (By similarity). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (PubMed:26721934). May act as a regulator of adipogenesis (By similarity). Indicus|evm.model.CM009510.1.331 Q8TE73 DYH5_HUMAN 89.724 0.999729 0.797145 DNAH5 - Dynein axonemal heavy chain 5 - Homo sapiens (Human) - DNAH5 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. Indicus|evm.model.CM009510.1.333 Q8WU90 ZC3HF_HUMAN 78.916 0.584416 0.542254 ZC3H15 - Zinc finger CCCH domain-containing protein 15 - Homo sapiens (Human) - ZC3H15 gene Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). Indicus|evm.model.CM009510.1.336 Q5EAE6 DAP1_BOVIN 98.077 0.515152 0.970588 DAP - Death-associated protein 1 - Bos taurus (Bovine) - DAP gene Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). Indicus|evm.model.CM009510.1.337 Q5EAE6 DAP1_BOVIN 100.000 0.847458 0.578431 DAP - Death-associated protein 1 - Bos taurus (Bovine) - DAP gene Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). Indicus|evm.model.CM009510.1.338 Q3U0L2 AN33B_MOUSE 79.091 0.988688 0.909465 Ankrd33b - Ankyrin repeat domain-containing protein 33B - Mus musculus (Mouse) - Ankrd33b gene Indicus|evm.model.CM009510.1.339 Q3T024 ROP1L_BOVIN 99.541 0.990868 1.00459 ROPN1L - Ropporin-1-like protein - Bos taurus (Bovine) - ROPN1L gene Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. Indicus|evm.model.CM009510.1.340 O60337 MARH6_HUMAN 98.343 0.979415 1.01429 MARCHF6 - E3 ubiquitin-protein ligase MARCHF6 - Homo sapiens (Human) - MARCHF6 gene E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (PubMed:15673284). Promotes ubiquitination of DIO2, leading to its degradation (PubMed:19651899). Promotes ubiquitination of SQLE, leading to its degradation (PubMed:24449766). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 (PubMed:15673284). Indicus|evm.model.CM009510.1.341 Q96DG6 CMBL_HUMAN 86.939 0.99187 1.00408 CMBL - Carboxymethylenebutenolidase homolog - Homo sapiens (Human) - CMBL gene Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. Indicus|evm.model.CM009510.1.342 Q4R6V2 TCPE_MACFA 97.412 0.99631 1.00185 CCT5 - T-complex protein 1 subunit epsilon - Macaca fascicularis (Crab-eating macaque) - CCT5 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.CM009510.1.343 Q6P4H8 ACKMT_HUMAN 83.258 0.990991 0.95279 ATPSCKMT - ATP synthase subunit C lysine N-methyltransferase - Homo sapiens (Human) - ATPSCKMT gene Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090). Indicus|evm.model.CM009510.1.347 Q13591 SEM5A_HUMAN 100.000 0.270718 0.168529 SEMA5A - Semaphorin-5A precursor - Homo sapiens (Human) - SEMA5A gene Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. Indicus|evm.model.CM009510.1.348 P0C1H5 H2B7_CHICK 92.188 0.875 0.571429 H2B-VII - Histone H2B 7 - Gallus gallus (Chicken) - H2B-VII gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009510.1.349 Q13591 SEM5A_HUMAN 88.801 0.779557 0.756052 SEMA5A - Semaphorin-5A precursor - Homo sapiens (Human) - SEMA5A gene Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. Indicus|evm.model.CM009510.1.351 Q4JIJ2 MTRR_BOVIN 99.568 0.997126 1.00144 MTRR - Methionine synthase reductase - Bos taurus (Bovine) - MTRR gene Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin. Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (By similarity). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme. Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (By similarity). Indicus|evm.model.CM009510.1.352 Q58CX2 FAKD3_BOVIN 99.545 0.996974 1.00152 FASTKD3 - FAST kinase domain-containing protein 3, mitochondrial precursor - Bos taurus (Bovine) - FASTKD3 gene Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity. Indicus|evm.model.CM009510.1.354 A4QMS7 CE049_HUMAN 76.136 0.956044 0.619048 C5orf49 - Uncharacterized protein C5orf49 - Homo sapiens (Human) - C5orf49 gene ciliary basal body Indicus|evm.model.CM009510.1.355 Q08462 ADCY2_HUMAN 98.830 0.880829 0.176902 ADCY2 - Adenylate cyclase type 2 - Homo sapiens (Human) - ADCY2 gene Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). Indicus|evm.model.CM009510.1.356 P07435 OBP_BOVIN 51.613 0.777778 1.24528 Odorant-binding protein - Bos taurus (Bovine) Indicus|evm.model.CM009510.1.358 Q5XG87 PAPD7_HUMAN 90.958 0.721569 0.990933 TENT4A - Terminal nucleotidyltransferase 4A - Homo sapiens (Human) - TENT4A gene Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078). Indicus|evm.model.CM009510.1.359 A5PJS2 S5A1_BOVIN 99.611 0.992248 1.00389 SRD5A1 - 3-oxo-5-alpha-steroid 4-dehydrogenase 1 - Bos taurus (Bovine) - SRD5A1 gene Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Indicus|evm.model.CM009510.1.360 Q08J23 NSUN2_HUMAN 88.529 0.855164 1.0352 NSUN2 - RNA cytosine C(5)-methyltransferase NSUN2 - Homo sapiens (Human) - NSUN2 gene RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31358969, PubMed:31199786). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). Indicus|evm.model.CM009510.1.361 Q5R6P5 MED10_PONAB 100.000 0.985294 1.00741 MED10 - Mediator of RNA polymerase II transcription subunit 10 - Pongo abelii (Sumatran orangutan) - MED10 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009510.1.362 Q86SX6 GLRX5_HUMAN 77.922 0.95 0.509554 GLRX5 - Glutaredoxin-related protein 5, mitochondrial precursor - Homo sapiens (Human) - GLRX5 gene Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:20364084, PubMed:23615440). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:20364084, PubMed:23615440, PubMed:24334290). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). Indicus|evm.model.CM009510.1.363 O15439 MRP4_HUMAN 78.261 0.978495 0.0701887 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009510.1.365 Q9Y2F5 ICE1_HUMAN 58.612 0.99909 0.96955 ICE1 - Little elongation complex subunit 1 - Homo sapiens (Human) - ICE1 gene Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). Indicus|evm.model.CM009510.1.367 Q8TE57 ATS16_HUMAN 75.328 0.954874 0.905229 ADAMTS16 - A disintegrin and metalloproteinase with thrombospondin motifs 16 precursor - Homo sapiens (Human) - ADAMTS16 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization Indicus|evm.model.CM009510.1.372 P78414 IRX1_HUMAN 86.027 0.798658 0.93125 IRX1 - Iroquois-class homeodomain protein IRX-1 - Homo sapiens (Human) - IRX1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, cell development, negative regulation of transcription by RNA polymerase II, neuron differentiation Indicus|evm.model.CM009510.1.380 Q9BZI1 IRX2_HUMAN 95.946 0.477124 0.324841 IRX2 - Iroquois-class homeodomain protein IRX-2 - Homo sapiens (Human) - IRX2 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, cell development, negative regulation of transcription by RNA polymerase II, neuron differentiation, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009510.1.394 P78413 IRX4_HUMAN 96.522 0.191597 1.14644 IRX4 - Iroquois-class homeodomain protein IRX-4 - Homo sapiens (Human) - IRX4 gene Likely to be an important mediator of ventricular differentiation during cardiac development. Indicus|evm.model.CM009510.1.395 P23934 NDUS6_BOVIN 100.000 0.984 1.00806 NDUFS6 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor - Bos taurus (Bovine) - NDUFS6 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009510.1.396 Q1LWG3 RM36_DANRE 57.778 0.435644 0.87069 mrpl36 - 39S ribosomal protein L36, mitochondrial precursor - Danio rerio (Zebrafish) - mrpl36 gene mitochondrial large ribosomal subunit, ribosome biogenesis Indicus|evm.model.CM009510.1.398 Q8NF37 PCAT1_HUMAN 83.690 0.52766 1.32022 LPCAT1 - Lysophosphatidylcholine acyltransferase 1 - Homo sapiens (Human) - LPCAT1 gene Exhibits acyltransferase activity (PubMed:21498505, PubMed:18156367). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198). Indicus|evm.model.CM009510.1.399 P27922 SC6A3_BOVIN 83.221 0.881818 0.47619 SLC6A3 - Sodium-dependent dopamine transporter - Bos taurus (Bovine) - SLC6A3 gene Amine transporter (PubMed:1722321). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). Indicus|evm.model.CM009510.1.400 P23977 SC6A3_RAT 91.057 0.638743 0.308562 Slc6a3 - Sodium-dependent dopamine transporter - Rattus norvegicus (Rat) - Slc6a3 gene Amine transporter (PubMed:1948035, PubMed:1948034, PubMed:1765147, PubMed:1502198). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (Probable) (PubMed:1765147). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). Indicus|evm.model.CM009510.1.401 P27922 SC6A3_BOVIN 98.592 0.501779 0.405483 SLC6A3 - Sodium-dependent dopamine transporter - Bos taurus (Bovine) - SLC6A3 gene Amine transporter (PubMed:1722321). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). Indicus|evm.model.CM009510.1.402 A2VE61 CLP1L_BOVIN 99.805 0.996101 0.953532 CLPTM1L - Cleft lip and palate transmembrane protein 1-like protein - Bos taurus (Bovine) - CLPTM1L gene Enhances cisplatin-mediated apoptosis, when overexpressed. Indicus|evm.model.CM009510.1.403 Q27ID4 TERT_BOVIN 99.676 0.249393 1.09778 TERT - Telomerase reverse transcriptase - Bos taurus (Bovine) - TERT gene Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis (By similarity). Indicus|evm.model.CM009510.1.404 Q96N87 S6A18_HUMAN 77.027 0.957861 0.982484 SLC6A18 - Inactive sodium-dependent neutral amino acid transporter B(0)AT3 - Homo sapiens (Human) - SLC6A18 gene Does not show neutral amino acid transporter activity. Indicus|evm.model.CM009510.1.405 Q2A865 S6A19_RAT 77.287 0.993421 0.958991 Slc6a19 - Sodium-dependent neutral amino acid transporter B(0)AT1 - Rattus norvegicus (Rat) - Slc6a19 gene Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity. Indicus|evm.model.CM009510.1.406 Q5RK27 S12A7_RAT 80.707 0.967456 0.936288 Slc12a7 - Solute carrier family 12 member 7 - Rattus norvegicus (Rat) - Slc12a7 gene Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). Indicus|evm.model.CM009510.1.407 Q969F2 NKD2_HUMAN 80.275 0.725753 0.662971 NKD2 - Protein naked cuticle homolog 2 - Homo sapiens (Human) - NKD2 gene Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. Indicus|evm.model.CM009510.1.411 D3K5L7 PCH2_PIG 95.370 0.995381 1.00464 TRIP13 - Pachytene checkpoint protein 2 homolog - Sus scrofa (Pig) - TRIP13 gene Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation (By similarity). Indicus|evm.model.CM009510.1.412 Q9H8M2 BRD9_HUMAN 88.312 0.995138 1.0335 BRD9 - Bromodomain-containing protein 9 - Homo sapiens (Human) - BRD9 gene Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Orchestrates also the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). Indicus|evm.model.CM009510.1.414 Q27957 TPPP_BOVIN 100.000 0.333846 2.98165 TPPP - Tubulin polymerization-promoting protein - Bos taurus (Bovine) - TPPP gene Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (By similarity). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (By similarity). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (By similarity). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (By similarity). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:14623963). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (By similarity). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (By similarity). Plays a role in cell proliferation by regulating the G1/S-phase transition (By similarity). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (By similarity). Indicus|evm.model.CM009510.1.415 Q9P209 CEP72_HUMAN 64.286 0.75 1.12519 CEP72 - Centrosomal protein of 72 kDa - Homo sapiens (Human) - CEP72 gene Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Indicus|evm.model.CM009510.1.417 P48764 SL9A3_HUMAN 88.738 0.962919 1.0024 SLC9A3 - Sodium/hydrogen exchanger 3 - Homo sapiens (Human) - SLC9A3 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction. Indicus|evm.model.CM009510.1.418 Q0V8C2 EXOC3_BOVIN 99.866 0.997319 1.00134 EXOC3 - Exocyst complex component 3 - Bos taurus (Bovine) - EXOC3 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Indicus|evm.model.CM009510.1.419 A9YTQ3 AHRR_HUMAN 46.450 0.938416 0.486448 AHRR - Aryl hydrocarbon receptor repressor - Homo sapiens (Human) - AHRR gene Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. Indicus|evm.model.CM009510.1.420 A9YTQ3 AHRR_HUMAN 64.571 0.801843 0.309558 AHRR - Aryl hydrocarbon receptor repressor - Homo sapiens (Human) - AHRR gene Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. Indicus|evm.model.CM009510.1.421 Q3U1U7 AHRR_MOUSE 88.525 0.227273 0.376605 Ahrr - Aryl hydrocarbon receptor repressor - Mus musculus (Mouse) - Ahrr gene Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. Indicus|evm.model.CM009510.1.422 P01865 GCAM_MOUSE 64.838 0.922535 1.07035 Igh-1a - Ig gamma-2A chain C region, membrane-bound form - Mus musculus (Mouse) - Igh-1a gene external side of plasma membrane, immunoglobulin complex, circulating, multivesicular body, antigen binding, immunoglobulin receptor binding, antibody-dependent cellular cytotoxicity, antigen processing and presentation, B cell receptor signaling pathway, complement activation, classical pathway, defense response to bacterium Indicus|evm.model.CM009510.1.423 P12815 PDCD6_MOUSE 97.906 0.632997 1.55497 Pdcd6 - Programmed cell death protein 6 - Mus musculus (Mouse) - Pdcd6 gene Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair (PubMed:10744743, PubMed:11525164, PubMed:27541325). Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:10744743, PubMed:11525164, PubMed:27541325). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:10744743, PubMed:11525164, PubMed:27541325). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (By similarity). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (By similarity). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (By similarity). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (By similarity). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (PubMed:8560270). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (By similarity). Its role in apoptosis may however be indirect, as suggested by knockout experiments (PubMed:12024023). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (By similarity). Indicus|evm.model.CM009510.1.424 P31039 SDHA_BOVIN 99.098 0.996997 1.0015 SDHA - Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor - Bos taurus (Bovine) - SDHA gene Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity). Indicus|evm.model.CM009510.1.426 P0C267 CC127_PIG 89.535 0.992278 1.00388 CCDC127 - Coiled-coil domain-containing protein 127 - Sus scrofa (Pig) - CCDC127 gene Indicus|evm.model.CM009510.1.427 A6NHZ5 LR14B_HUMAN 79.843 0.996094 0.996109 LRRC14B - Leucine-rich repeat-containing protein 14B - Homo sapiens (Human) - LRRC14B gene cytoplasm Indicus|evm.model.CM009511.1.1 Q17QN3 RSMN_BOVIN 100.000 0.991701 1.00417 SNRPN - Small nuclear ribonucleoprotein-associated protein N - Bos taurus (Bovine) - SNRPN gene May be involved in tissue-specific alternative RNA processing events. Indicus|evm.model.CM009511.1.2 Q9XS96 SNURF_BOVIN 96.970 0.970149 0.943662 SNURF - SNRPN upstream reading frame protein - Bos taurus (Bovine) - SNURF gene nuclear speck Indicus|evm.model.CM009511.1.3 Q99608 NECD_HUMAN 87.730 0.993865 1.01558 NDN - Necdin - Homo sapiens (Human) - NDN gene Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity). Indicus|evm.model.CM009511.1.4 Q9UJ55 MAGL2_HUMAN 72.178 0.998311 0.947958 MAGEL2 - MAGE-like protein 2 - Homo sapiens (Human) - MAGEL2 gene Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (PubMed:23452853). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (By similarity). Indicus|evm.model.CM009511.1.5 Q13064 MKRN3_HUMAN 65.053 0.9869 0.903353 MKRN3 - Probable E3 ubiquitin-protein ligase makorin-3 - Homo sapiens (Human) - MKRN3 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Indicus|evm.model.CM009511.1.11 Q9UPS8 ANR26_HUMAN 51.252 0.992172 0.29883 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009511.1.13 Q13136 LIPA1_HUMAN 52.083 0.476667 0.249584 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009511.1.14 Q13136 LIPA1_HUMAN 75.000 0.410526 0.0790349 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009511.1.15 Q13136 LIPA1_HUMAN 67.213 0.535714 0.093178 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009511.1.16 Q9NPG1 FZD3_HUMAN 89.080 0.97191 0.267267 FZD3 - Frizzled-3 precursor - Homo sapiens (Human) - FZD3 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity). Indicus|evm.model.CM009511.1.17 Q13136 LIPA1_HUMAN 68.235 0.473054 0.138935 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009511.1.19 Q9UPS8 ANR26_HUMAN 80.159 0.142045 0.51462 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009511.1.20 Q9UPS8 ANR26_HUMAN 64.286 0.987654 0.0947368 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009511.1.21 Q9D6Y1 CCDC3_MOUSE 82.353 0.808 0.457875 Ccdc3 - Coiled-coil domain-containing protein 3 precursor - Mus musculus (Mouse) - Ccdc3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells (PubMed:25605713). Indicus|evm.model.CM009511.1.22 Q9UPS8 ANR26_HUMAN 81.287 0.965909 0.102924 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009511.1.23 Q21049 LIPA_CAEEL 70.130 0.107955 0.618086 syd-2 - Liprin-alpha - Caenorhabditis elegans - syd-2 gene May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse (PubMed:10517634, PubMed:19290026). This may be in association with the liprin-beta protein hlb-1 (PubMed:19290026). Indicus|evm.model.CM009511.1.24 Q13136 LIPA1_HUMAN 66.234 0.77551 0.0815308 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009511.1.25 Q13136 LIPA1_HUMAN 80.882 0.271255 0.205491 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009511.1.26 Q13136 LIPA1_HUMAN 48.148 0.497118 0.577371 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009511.1.27 Q13136 LIPA1_HUMAN 68.085 0.0691824 0.529118 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009511.1.30 Q05086 UBE3A_HUMAN 97.133 0.993151 1.00114 UBE3A - Ubiquitin-protein ligase E3A - Homo sapiens (Human) - UBE3A gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990). Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Indicus|evm.model.CM009511.1.33 O60312 AT10A_HUMAN 80.492 0.895983 0.929953 ATP10A - Phospholipid-transporting ATPase VA - Homo sapiens (Human) - ATP10A gene Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane (PubMed:25947375, PubMed:29599178, PubMed:30530492). Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking (PubMed:29599178). Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix (PubMed:29599178, PubMed:25947375). Has low flippase activity toward glucosylceramide (GlcCer) (PubMed:30530492). Indicus|evm.model.CM009511.1.34 O54827 AT10A_MOUSE 74.737 0.404444 0.149204 Atp10a - Phospholipid-transporting ATPase VA - Mus musculus (Mouse) - Atp10a gene Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer). Indicus|evm.model.CM009511.1.35 O60312 AT10A_HUMAN 88.983 0.375817 0.204136 ATP10A - Phospholipid-transporting ATPase VA - Homo sapiens (Human) - ATP10A gene Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane (PubMed:25947375, PubMed:29599178, PubMed:30530492). Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking (PubMed:29599178). Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix (PubMed:29599178, PubMed:25947375). Has low flippase activity toward glucosylceramide (GlcCer) (PubMed:30530492). Indicus|evm.model.CM009511.1.41 P28472 GBRB3_HUMAN 97.215 0.827368 1.00423 GABRB3 - Gamma-aminobutyric acid receptor subunit beta-3 precursor - Homo sapiens (Human) - GABRB3 gene Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Plays an important role in somatosensation and in the production of antinociception (By similarity). Indicus|evm.model.CM009511.1.42 Q08E50 GBRA5_BOVIN 99.784 0.99568 1.00216 GABRA5 - Gamma-aminobutyric acid receptor subunit alpha-5 precursor - Bos taurus (Bovine) - GABRA5 gene Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse. Indicus|evm.model.CM009511.1.43 P61247 RS3A_HUMAN 91.089 0.952381 0.397727 RPS3A - 40S ribosomal protein S3a - Homo sapiens (Human) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009511.1.44 Q5R893 H2B1_PONAB 92.857 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009511.1.45 Q99928 GBRG3_HUMAN 72.727 0.981982 0.237687 GABRG3 - Gamma-aminobutyric acid receptor subunit gamma-3 precursor - Homo sapiens (Human) - GABRG3 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Indicus|evm.model.CM009511.1.47 Q2TBY0 SKA2_BOVIN 93.388 0.983607 1.00826 SKA2 - Spindle and kinetochore-associated protein 2 - Bos taurus (Bovine) - SKA2 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Indicus|evm.model.CM009511.1.48 Q2KI76 SELS_BOVIN 100.000 0.989418 0.994737 SELENOS - Selenoprotein S - Bos taurus (Bovine) - SELENOS gene Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). Indicus|evm.model.CM009511.1.49 Q86X52 CHSS1_HUMAN 97.468 0.997191 0.887781 CHSY1 - Chondroitin sulfate synthase 1 - Homo sapiens (Human) - CHSY1 gene Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. Indicus|evm.model.CM009511.1.50 Q38SD2 LRRK1_HUMAN 89.087 0.999008 1.0005 LRRK1 - Leucine-rich repeat serine/threonine-protein kinase 1 - Homo sapiens (Human) - LRRK1 gene cytoplasm, cytosol, intracellular membrane-bounded organelle, mitochondrion, identical protein binding, protein serine/threonine phosphatase activity, positive regulation of canonical Wnt signaling pathway, signal transduction Indicus|evm.model.CM009511.1.51 P47895 AL1A3_HUMAN 94.154 0.931774 1.00195 ALDH1A3 - Aldehyde dehydrogenase family 1 member A3 - Homo sapiens (Human) - ALDH1A3 gene NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity). Indicus|evm.model.CM009511.1.52 P01819 HVM43_MOUSE 66.364 0.631579 1.1875 Ig heavy chain V region MOPC 141 precursor - Mus musculus (Mouse) Indicus|evm.model.CM009511.1.53 Q9H672 ASB7_HUMAN 100.000 0.99373 1.00314 ASB7 - Ankyrin repeat and SOCS box protein 7 - Homo sapiens (Human) - ASB7 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009511.1.54 Q8NG48 LINES_HUMAN 72.619 0.993412 1.00264 LINS1 - Protein Lines homolog 1 - Homo sapiens (Human) - LINS1 gene cognition Indicus|evm.model.CM009511.1.55 Q8IU89 CERS3_HUMAN 72.449 0.992593 0.704961 CERS3 - Ceramide synthase 3 - Homo sapiens (Human) - CERS3 gene Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960). Indicus|evm.model.CM009511.1.56 Q8TE56 ATS17_HUMAN 82.084 0.960282 1.0347 ADAMTS17 - A disintegrin and metalloproteinase with thrombospondin motifs 17 precursor - Homo sapiens (Human) - ADAMTS17 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization Indicus|evm.model.CM009511.1.57 Q5REP3 LYSM4_PONAB 78.351 0.864865 0.375 LYSMD4 - LysM and putative peptidoglycan-binding domain-containing protein 4 - Pongo abelii (Sumatran orangutan) - LYSMD4 gene Indicus|evm.model.CM009511.1.58 Q5REP3 LYSM4_PONAB 75.962 0.873418 0.800676 LYSMD4 - LysM and putative peptidoglycan-binding domain-containing protein 4 - Pongo abelii (Sumatran orangutan) - LYSMD4 gene Indicus|evm.model.CM009511.1.59 Q5REW7 MEF2A_PONAB 93.648 0.936047 1.04453 MEF2A - Myocyte-specific enhancer factor 2A - Pongo abelii (Sumatran orangutan) - MEF2A gene Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.Associates with chromatin to the ZNF16 promoter (By similarity). Indicus|evm.model.CM009511.1.60 Q32KX5 LRC28_BOVIN 99.728 0.994565 1.00272 LRRC28 - Leucine-rich repeat-containing protein 28 - Bos taurus (Bovine) - LRRC28 gene Indicus|evm.model.CM009511.1.61 Q2KHY7 TTC23_BOVIN 99.022 0.995122 0.919283 TTC23 - Tetratricopeptide repeat protein 23 - Bos taurus (Bovine) - TTC23 gene Partcipates positively in the ciliary Hedgehog (Hh) signaling. Indicus|evm.model.CM009511.1.62 O15061 SYNEM_HUMAN 87.129 0.0615385 1.03834 SYNM - Synemin - Homo sapiens (Human) - SYNM gene Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. Indicus|evm.model.CM009511.1.63 P08069 IGF1R_HUMAN 97.814 0.467866 0.284565 IGF1R - Insulin-like growth factor 1 receptor precursor - Homo sapiens (Human) - IGF1R gene Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R. Indicus|evm.model.CM009511.1.65 Q05688 IGF1R_BOVIN 100.000 0.534728 1.86719 IGF1R - Insulin-like growth factor 1 receptor precursor - Bos taurus (Bovine) - IGF1R gene Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R (By similarity). When present in a hybrid receptor with INSR, binds IGF1 (By similarity). Indicus|evm.model.CM009511.1.66 Q9CWB5 PGPIL_MOUSE 74.016 0.642857 1.50769 Pgpep1l - Pyroglutamyl-peptidase 1-like protein - Mus musculus (Mouse) - Pgpep1l gene proteolysis Indicus|evm.model.CM009511.1.67 Q8N8A8 F169B_HUMAN 78.195 0.392857 1.75 FAM169B - Protein FAM169B - Homo sapiens (Human) - FAM169B gene Indicus|evm.model.CM009511.1.70 Q8NCT1 ARRD4_HUMAN 90.933 0.994595 0.885167 ARRDC4 - Arrestin domain-containing protein 4 - Homo sapiens (Human) - ARRDC4 gene Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake (PubMed:19605364). Indicus|evm.model.CM009511.1.74 Q9TTR7 COT2_BOVIN 97.818 0.971631 0.681159 NR2F2 - COUP transcription factor 2 - Bos taurus (Bovine) - NR2F2 gene Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development. Indicus|evm.model.CM009511.1.78 Q6DN12 MCTP2_HUMAN 90.557 0.961665 1.03986 MCTP2 - Multiple C2 and transmembrane domain-containing protein 2 - Homo sapiens (Human) - MCTP2 gene Might play a role in the development of cardiac outflow tract. Indicus|evm.model.CM009511.1.79 P48305 NDUB4_BOVIN 92.248 0.984615 1.00775 NDUFB4 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 - Bos taurus (Bovine) - NDUFB4 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009511.1.80 Q3MHM7 RL35_BOVIN 98.374 0.983871 1.00813 RPL35 - 60S ribosomal protein L35 - Bos taurus (Bovine) - RPL35 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009511.1.81 Q96B86 RGMA_HUMAN 91.954 0.951754 1.01333 RGMA - Repulsive guidance molecule A precursor - Homo sapiens (Human) - RGMA gene Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. Indicus|evm.model.CM009511.1.83 Q1RMK9 F174B_BOVIN 98.684 0.681818 0.691824 FAM174B - Membrane protein FAM174B precursor - Bos taurus (Bovine) - FAM174B gene Essential for Golgi structural integrity. Indicus|evm.model.CM009511.1.84 Q92186 SIA8B_HUMAN 98.447 0.922414 0.928 ST8SIA2 - Alpha-2,8-sialyltransferase 8B - Homo sapiens (Human) - ST8SIA2 gene May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression. Indicus|evm.model.CM009511.1.85 Q07977 SIA8B_RAT 94.286 0.390805 0.232 St8sia2 - Alpha-2,8-sialyltransferase 8B - Rattus norvegicus (Rat) - St8sia2 gene May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression. Indicus|evm.model.CM009511.1.86 Q8HYW2 SO3A1_BOVIN 100.000 0.978175 0.709859 SLCO3A1 - Solute carrier organic anion transporter family member 3A1 - Bos taurus (Bovine) - SLCO3A1 gene Mediates the Na(+)-independent transport of organic anions. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin. Indicus|evm.model.CM009511.1.87 Q8HYW2 SO3A1_BOVIN 100.000 0.873469 0.34507 SLCO3A1 - Solute carrier organic anion transporter family member 3A1 - Bos taurus (Bovine) - SLCO3A1 gene Mediates the Na(+)-independent transport of organic anions. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin. Indicus|evm.model.CM009511.1.88 Q12802 AKP13_HUMAN 94.416 0.975124 0.071454 AKAP13 - A-kinase anchor protein 13 - Homo sapiens (Human) - AKAP13 gene Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). Indicus|evm.model.CM009511.1.89 Q7L1I2 SV2B_HUMAN 94.876 0.997076 1.00146 SV2B - Synaptic vesicle glycoprotein 2B - Homo sapiens (Human) - SV2B gene Probably plays a role in the control of regulated secretion in neural and endocrine cells. Indicus|evm.model.CM009511.1.90 F1M3G7 AKP13_RAT 80.266 0.161101 0.987319 Akap13 - A-kinase anchor protein 13 - Rattus norvegicus (Rat) - Akap13 gene Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:17537920). May also activate other Rho family members. Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (By similarity). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (PubMed:20139090). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (By similarity). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (By similarity). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (By similarity). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920). Required for normal adaptive cardiac hypertrophy in response to pressure overload (By similarity). Plays a role in osteogenesis (By similarity). Indicus|evm.model.CM009511.1.93 Q9H0H3 KLH25_HUMAN 95.586 0.99661 1.0017 KLHL25 - Kelch-like protein 25 - Homo sapiens (Human) - KLHL25 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. Indicus|evm.model.CM009511.1.97 Q96MI9 CBPC4_HUMAN 56.452 0.822917 0.0863309 AGBL1 - Cytosolic carboxypeptidase 4 - Homo sapiens (Human) - AGBL1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Indicus|evm.model.CM009511.1.98 Q96MI9 CBPC4_HUMAN 71.611 0.981191 0.573741 AGBL1 - Cytosolic carboxypeptidase 4 - Homo sapiens (Human) - AGBL1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Indicus|evm.model.CM009511.1.99 Q96MI9 CBPC4_HUMAN 95.082 0.810811 0.0665468 AGBL1 - Cytosolic carboxypeptidase 4 - Homo sapiens (Human) - AGBL1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Indicus|evm.model.CM009511.1.100 P21327 INPP_BOVIN 82.418 0.687023 0.3275 INPP1 - Inositol polyphosphate 1-phosphatase - Bos taurus (Bovine) - INPP1 gene inositol-1,4-bisphosphate 1-phosphatase activity, inositol phosphate dephosphorylation Indicus|evm.model.CM009511.1.101 Q09M05 CBPC4_MOUSE 95.745 0.479167 0.0855615 Agbl1 - Cytosolic carboxypeptidase 4 - Mus musculus (Mouse) - Agbl1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Indicus|evm.model.CM009511.1.103 Q09M05 CBPC4_MOUSE 57.377 0.536364 0.0980392 Agbl1 - Cytosolic carboxypeptidase 4 - Mus musculus (Mouse) - Agbl1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Indicus|evm.model.CM009511.1.105 Q5IS37 NTRK3_PANTR 100.000 0.973597 0.367273 NTRK3 - NT-3 growth factor receptor precursor - Pan troglodytes (Chimpanzee) - NTRK3 gene Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Indicus|evm.model.CM009511.1.106 Q16288 NTRK3_HUMAN 97.625 0.895522 0.558999 NTRK3 - NT-3 growth factor receptor precursor - Homo sapiens (Human) - NTRK3 gene Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Indicus|evm.model.CM009511.1.107 P24786 NTRK3_PIG 98.810 0.674797 0.149091 NTRK3 - NT-3 growth factor receptor precursor - Sus scrofa (Pig) - NTRK3 gene Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Indicus|evm.model.CM009511.1.109 Q3SZ22 RM46_BOVIN 99.639 0.992806 1.00361 MRPL46 - 39S ribosomal protein L46, mitochondrial precursor - Bos taurus (Bovine) - MRPL46 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009511.1.110 P82911 RT11_BOVIN 99.492 0.989899 1.00508 MRPS11 - 28S ribosomal protein S11, mitochondrial precursor - Bos taurus (Bovine) - MRPS11 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation, peptide biosynthetic process Indicus|evm.model.CM009511.1.111 Q9D0A0 DET1_MOUSE 98.909 0.915 1.09091 Det1 - DET1 homolog - Mus musculus (Mouse) - Det1 gene Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation (By similarity). Indicus|evm.model.CM009511.1.112 Q5REE2 AEN_PONAB 82.540 0.718535 1.34462 AEN - Apoptosis-enhancing nuclease - Pongo abelii (Sumatran orangutan) - AEN gene Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity). Indicus|evm.model.CM009511.1.113 Q96AZ6 ISG20_HUMAN 79.290 0.976744 0.950276 ISG20 - Interferon-stimulated gene 20 kDa protein - Homo sapiens (Human) - ISG20 gene Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. Indicus|evm.model.CM009511.1.114 Q5R6H1 MYADM_PONAB 49.286 0.505435 1.71429 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.115 Q96S97 MYADM_HUMAN 60.791 0.882166 0.975155 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.116 Q5R6H1 MYADM_PONAB 61.818 0.832827 1.02174 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.117 O35682 MYADM_MOUSE 48.544 0.761194 0.41875 Myadm - Myeloid-associated differentiation marker - Mus musculus (Mouse) - Myadm gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.118 Q5R6H1 MYADM_PONAB 46.575 0.822581 0.385093 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.119 Q5R6H1 MYADM_PONAB 56.250 0.303226 0.481366 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.120 Q5R6H1 MYADM_PONAB 61.733 0.592275 1.4472 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.122 Q5R6H1 MYADM_PONAB 55.804 0.43301 1.59938 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.124 Q96S97 MYADM_HUMAN 52.174 0.182186 0.767081 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.126 Q5R6H1 MYADM_PONAB 56.343 0.723757 1.12422 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.128 Q5R6H1 MYADM_PONAB 61.011 0.932432 0.919255 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.129 Q5R6H1 MYADM_PONAB 53.957 0.829341 1.03727 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.131 Q5R6H1 MYADM_PONAB 48.594 0.669697 1.02484 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.132 Q6VBQ5 MYADM_RAT 54.762 0.721739 0.361635 Myadm - Myeloid-associated differentiation marker - Rattus norvegicus (Rat) - Myadm gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.133 Q96S97 MYADM_HUMAN 62.130 0.933333 0.559006 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.135 Q96S97 MYADM_HUMAN 60.791 0.92953 0.925466 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.136 Q96S97 MYADM_HUMAN 56.039 0.672131 0.947205 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.137 Q5R6H1 MYADM_PONAB 54.167 0.826733 0.627329 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.140 Q96S97 MYADM_HUMAN 63.370 0.896667 0.931677 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.141 Q5R6H1 MYADM_PONAB 60.432 0.92953 0.925466 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.142 Q5R6H1 MYADM_PONAB 61.649 0.86014 0.888199 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.143 Q5R6H1 MYADM_PONAB 60.584 0.873786 0.959627 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.144 Q5R6H1 MYADM_PONAB 60.145 0.854037 1 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.145 Q5R6H1 MYADM_PONAB 61.056 0.973244 0.928571 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.146 Q96S97 MYADM_HUMAN 65.343 0.896104 0.956522 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.147 Q96S97 MYADM_HUMAN 60.932 0.901639 0.947205 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.148 Q5R6H1 MYADM_PONAB 46.061 0.947059 0.52795 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.150 Q5R6H1 MYADM_PONAB 57.196 0.945848 0.860248 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.151 Q5R6H1 MYADM_PONAB 62.687 0.852564 0.968944 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.153 Q96S97 MYADM_HUMAN 61.871 0.882166 0.975155 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.154 Q96S97 MYADM_HUMAN 60.289 0.881789 0.97205 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.155 Q96S97 MYADM_HUMAN 60.650 0.881789 0.97205 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.156 Q96S97 MYADM_HUMAN 60.289 0.881789 0.97205 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Indicus|evm.model.CM009511.1.157 Q5R6H1 MYADM_PONAB 66.423 0.944637 0.897516 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Indicus|evm.model.CM009511.1.158 P13608 PGCA_BOVIN 99.408 0.999155 1.00127 ACAN - Aggrecan core protein precursor - Bos taurus (Bovine) - ACAN gene This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. Indicus|evm.model.CM009511.1.159 Q96S86 HPLN3_HUMAN 82.164 0.944598 1.00278 HAPLN3 - Hyaluronan and proteoglycan link protein 3 precursor - Homo sapiens (Human) - HAPLN3 gene May function in hyaluronic acid binding. Indicus|evm.model.CM009511.1.160 Q95114 MFGM_BOVIN 98.608 0.99537 1.01171 MFGE8 - Lactadherin precursor - Bos taurus (Bovine) - MFGE8 gene Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Indicus|evm.model.CM009511.1.162 Q5EA42 ABHD2_BOVIN 100.000 0.995305 1.00235 ABHD2 - Monoacylglycerol lipase ABHD2 - Bos taurus (Bovine) - ABHD2 gene Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). May also play a role in smooth muscle cells migration (By similarity). Indicus|evm.model.CM009511.1.163 P10123 RLBP1_BOVIN 93.590 0.981013 0.498423 RLBP1 - Retinaldehyde-binding protein 1 - Bos taurus (Bovine) - RLBP1 gene Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. Indicus|evm.model.CM009511.1.164 Q9NVI1 FANCI_HUMAN 84.807 0.989458 1 FANCI - Fanconi anemia group I protein - Homo sapiens (Human) - FANCI gene Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. Indicus|evm.model.CM009511.1.165 P54098 DPOG1_HUMAN 87.844 0.998358 0.983051 POLG - DNA polymerase subunit gamma-1 - Homo sapiens (Human) - POLG gene Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA. Indicus|evm.model.CM009511.1.166 P10123 RLBP1_BOVIN 100.000 0.820755 0.66877 RLBP1 - Retinaldehyde-binding protein 1 - Bos taurus (Bovine) - RLBP1 gene Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. Indicus|evm.model.CM009511.1.167 Q2T9S6 RHCG_BOVIN 99.348 0.995662 1.00217 RHCG - Ammonium transporter Rh type C - Bos taurus (Bovine) - RHCG gene Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion (By similarity). Indicus|evm.model.CM009511.1.168 Q7Z2Z1 TICRR_HUMAN 71.904 0.998424 0.996335 TICRR - Treslin - Homo sapiens (Human) - TICRR gene Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. Indicus|evm.model.CM009511.1.169 Q2M1P5 KIF7_HUMAN 95.052 0.276335 1.03202 KIF7 - Kinesin-like protein KIF7 - Homo sapiens (Human) - KIF7 gene Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). Indicus|evm.model.CM009511.1.170 O60240 PLIN1_HUMAN 84.483 0.996132 0.990421 PLIN1 - Perilipin-1 - Homo sapiens (Human) - PLIN1 gene Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. Indicus|evm.model.CM009511.1.171 Q0VCP2 PX11A_BOVIN 100.000 0.991935 1.00405 PEX11A - Peroxisomal membrane protein 11A - Bos taurus (Bovine) - PEX11A gene May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface. Indicus|evm.model.CM009511.1.172 Q6P2C0 WDR93_HUMAN 72.542 0.556818 0.769679 WDR93 - WD repeat-containing protein 93 - Homo sapiens (Human) - WDR93 gene mitochondrial respiratory chain complex I Indicus|evm.model.CM009511.1.173 Q0VG99 MESP2_HUMAN 63.333 0.994872 0.982368 MESP2 - Mesoderm posterior protein 2 - Homo sapiens (Human) - MESP2 gene Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Indicus|evm.model.CM009511.1.174 P79098 AMPN_BOVIN 99.275 0.99793 1.00104 ANPEP - Aminopeptidase N - Bos taurus (Bovine) - ANPEP gene Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). Indicus|evm.model.CM009511.1.176 Q1JQA3 AP3S2_BOVIN 100.000 0.989691 1.00518 AP3S2 - AP-3 complex subunit sigma-2 - Bos taurus (Bovine) - AP3S2 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). Indicus|evm.model.CM009511.1.177 Q17QU3 ARPIN_BOVIN 99.115 0.991189 1.00442 ARPIN - Arpin - Bos taurus (Bovine) - ARPIN gene Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity). Indicus|evm.model.CM009511.1.178 Q8N1W2 ZN710_HUMAN 94.578 0.96087 1.03916 ZNF710 - Zinc finger protein 710 - Homo sapiens (Human) - ZNF710 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009511.1.179 Q04467 IDHP_BOVIN 100.000 0.995585 1.00221 IDH2 - Isocitrate dehydrogenase [NADP], mitochondrial precursor - Bos taurus (Bovine) - IDH2 gene Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. Indicus|evm.model.CM009511.1.180 Q9NPR2 SEM4B_HUMAN 81.407 0.957524 0.984468 SEMA4B - Semaphorin-4B precursor - Homo sapiens (Human) - SEMA4B gene Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Indicus|evm.model.CM009511.1.181 B1A8Z2 CIB1_SHEEP 100.000 0.989583 1.00524 CIB1 - Calcium and integrin-binding protein 1 - Ovis aries (Sheep) - CIB1 gene Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells (By similarity). Indicus|evm.model.CM009511.1.182 Q5E9T1 GDPP1_BOVIN 99.740 0.994819 1.0026 GDPGP1 - GDP-D-glucose phosphorylase 1 - Bos taurus (Bovine) - GDPGP1 gene Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. Indicus|evm.model.CM009511.1.183 A4Q9F6 TTL13_MOUSE 60.606 0.560345 0.144279 Ttll13 - Tubulin polyglutamylase TTLL13 - Mus musculus (Mouse) - Ttll13 gene Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Indicus|evm.model.CM009511.1.184 Q2HJC0 NGRN_BOVIN 99.652 0.993056 1.00348 NGRN - Neugrin precursor - Bos taurus (Bovine) - NGRN gene Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. Indicus|evm.model.CM009511.1.185 Q2HJ18 VP33B_BOVIN 99.838 0.996764 1.00162 VPS33B - Vacuolar protein sorting-associated protein 33B - Bos taurus (Bovine) - VPS33B gene May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity). Indicus|evm.model.CM009511.1.186 O43663 PRC1_HUMAN 83.871 0.996491 0.919355 PRC1 - Protein regulator of cytokinesis 1 - Homo sapiens (Human) - PRC1 gene Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). Indicus|evm.model.CM009511.1.187 Q4R828 RCCD1_MACFA 79.947 0.994709 1.00532 RCCD1 - RCC1 domain-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - RCCD1 gene Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8. Indicus|evm.model.CM009511.1.188 Q9H3U1 UN45A_HUMAN 94.280 0.997884 1.00106 UNC45A - Protein unc-45 homolog A - Homo sapiens (Human) - UNC45A gene Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). Indicus|evm.model.CM009511.1.190 Q8N4P3 MESH1_HUMAN 93.855 0.988889 1.00559 HDDC3 - Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 - Homo sapiens (Human) - HDDC3 gene ppGpp hydrolyzing enzyme involved in starvation response. Indicus|evm.model.CM009511.1.191 P49641 MA2A2_HUMAN 92.000 0.566289 1.76435 MAN2A2 - Alpha-mannosidase 2x - Homo sapiens (Human) - MAN2A2 gene Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Indicus|evm.model.CM009511.1.192 Q28193 FURIN_BOVIN 99.749 0.862405 1.15809 FURIN - Furin precursor - Bos taurus (Bovine) - FURIN gene Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:7806563). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). Indicus|evm.model.CM009511.1.193 P54132 BLM_HUMAN 81.704 0.998602 1.00988 BLM - Bloom syndrome protein - Homo sapiens (Human) - BLM gene ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9388193, PubMed:24816114, PubMed:25901030). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (PubMed:20639533, PubMed:24257077, PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). Indicus|evm.model.CM009511.1.194 Q6UUV7 CRTC3_HUMAN 87.500 0.962649 0.951535 CRTC3 - CREB-regulated transcription coactivator 3 - Homo sapiens (Human) - CRTC3 gene Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). Indicus|evm.model.CM009511.1.195 P46940 IQGA1_HUMAN 96.435 0.998771 0.982498 IQGAP1 - Ras GTPase-activating-like protein IQGAP1 - Homo sapiens (Human) - IQGAP1 gene Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). Indicus|evm.model.CM009511.1.196 Q6NX45 ZN774_HUMAN 93.089 0.782748 0.648033 ZNF774 - Zinc finger protein 774 - Homo sapiens (Human) - ZNF774 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009511.1.197 Q7Z7L9 ZSCA2_HUMAN 88.293 0.8734 1.14495 ZSCAN2 - Zinc finger and SCAN domain-containing protein 2 - Homo sapiens (Human) - ZSCAN2 gene May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. Indicus|evm.model.CM009511.1.198 Q6P4I2 WDR73_HUMAN 73.810 0.994083 0.89418 WDR73 - WD repeat-containing protein 73 - Homo sapiens (Human) - WDR73 gene May play a role in the regulation of microtubule organization and dynamics (PubMed:25466283). Indicus|evm.model.CM009511.1.199 Q2T9U8 NMB_BOVIN 98.198 0.859375 1.05785 NMB - Neuromedin-B precursor - Bos taurus (Bovine) - NMB gene Stimulates smooth muscle contraction in a manner similar to that of bombesin. Indicus|evm.model.CM009511.1.200 Q5R9C7 SC11A_PONAB 100.000 0.988889 1.00559 SEC11A - Signal peptidase complex catalytic subunit SEC11A - Pongo abelii (Sumatran orangutan) - SEC11A gene Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Indicus|evm.model.CM009511.1.201 Q92610 ZN592_HUMAN 86.824 0.975309 1.02289 ZNF592 - Zinc finger protein 592 - Homo sapiens (Human) - ZNF592 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009511.1.202 Q96L96 ALPK3_HUMAN 75.796 0.986111 0.86838 ALPK3 - Alpha-protein kinase 3 - Homo sapiens (Human) - ALPK3 gene Involved in cardiomyocyte differentiation. Indicus|evm.model.CM009511.1.203 O62667 S28A1_PIG 89.669 0.50104 0.743431 SLC28A1 - Sodium/nucleoside cotransporter 1 - Sus scrofa (Pig) - SLC28A1 gene Sodium-dependent and pyrimidine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs. Transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). Indicus|evm.model.CM009511.1.204 P52732 KIF11_HUMAN 72.381 0.762332 0.211174 KIF11 - Kinesin-like protein KIF11 - Homo sapiens (Human) - KIF11 gene Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). Indicus|evm.model.CM009511.1.205 O60658 PDE8A_HUMAN 60.274 0.972973 0.0892642 PDE8A - High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A - Homo sapiens (Human) - PDE8A gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). Indicus|evm.model.CM009511.1.206 O60658 PDE8A_HUMAN 88.507 0.997347 0.90953 PDE8A - High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A - Homo sapiens (Human) - PDE8A gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). Indicus|evm.model.CM009511.1.208 Q6QAP7 RS17_PIG 100.000 0.650485 1.52593 RPS17 - 40S ribosomal protein S17 - Sus scrofa (Pig) - RPS17 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit Indicus|evm.model.CM009511.1.209 Q5R733 CPEB1_PONAB 98.354 0.782258 1.27572 CPEB1 - Cytoplasmic polyadenylation element-binding protein 1 - Pongo abelii (Sumatran orangutan) - CPEB1 gene Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry. Indicus|evm.model.CM009511.1.210 Q9JME5 AP3B2_MOUSE 98.837 0.632597 1.0037 Ap3b2 - AP-3 complex subunit beta-2 - Mus musculus (Mouse) - Ap3b2 gene Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Indicus|evm.model.CM009511.1.212 A1L4K1 FSD2_HUMAN 85.306 0.974633 1 FSD2 - Fibronectin type III and SPRY domain-containing protein 2 - Homo sapiens (Human) - FSD2 gene nucleus, perinuclear region of cytoplasm, sarcoplasmic reticulum Indicus|evm.model.CM009511.1.213 Q1A5X7 WHAL1_HUMAN 82.301 0.143774 5.0915 WHAMMP3 - Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1 - Homo sapiens (Human) - WHAMMP3 gene cytoplasm, endoplasmic reticulum-Golgi intermediate compartment membrane, Arp2/3 complex binding, Arp2/3 complex-mediated actin nucleation, cell cycle arrest, endoplasmic reticulum to Golgi vesicle-mediated transport Indicus|evm.model.CM009511.1.214 Q9NSB8 HOME2_HUMAN 93.182 0.790698 1.21469 HOMER2 - Homer protein homolog 2 - Homo sapiens (Human) - HOMER2 gene Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). Indicus|evm.model.CM009511.1.216 Q5R9Q6 RAMAC_PONAB 93.220 0.983193 1.00847 RAMAC - RNA guanine-N7 methyltransferase activating subunit - Pongo abelii (Sumatran orangutan) - RAMAC gene Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT. Regulates RNMT expression by a post-transcriptional stabilizing mechanism. Binds RNA. Indicus|evm.model.CM009511.1.217 Q3ZBP8 CO040_BOVIN 92.647 0.762712 1.40476 UPF0235 protein C15orf40 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009511.1.221 Q9NR30 DDX21_HUMAN 68.060 0.907937 0.402299 DDX21 - Nucleolar RNA helicase 2 - Homo sapiens (Human) - DDX21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Indicus|evm.model.CM009511.1.222 Q6ZN04 MEX3B_HUMAN 94.771 0.995652 0.808436 MEX3B - RNA-binding protein MEX3B - Homo sapiens (Human) - MEX3B gene RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms. Indicus|evm.model.CM009511.1.223 Q3UE17 MEX3D_MOUSE 100.000 0.130208 0.2986 Mex3d - RNA-binding protein MEX3D - Mus musculus (Mouse) - Mex3d gene RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. Indicus|evm.model.CM009511.1.224 Q7Z2Z2 EFL1_HUMAN 92.028 0.99823 1.00893 EFL1 - Elongation factor-like GTPase 1 - Homo sapiens (Human) - EFL1 gene Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits. Indicus|evm.model.CM009511.1.225 Q658L1 SAXO2_HUMAN 75.907 0.846154 1.14322 SAXO2 - Stabilizer of axonemal microtubules 2 - Homo sapiens (Human) - SAXO2 gene axonemal microtubule, centriole, ciliary basal body, cytoskeleton, sperm flagellum, microtubule binding, microtubule anchoring Indicus|evm.model.CM009511.1.226 P82987 ATL3_HUMAN 77.419 0.648936 0.0555884 ADAMTSL3 - ADAMTS-like protein 3 precursor - Homo sapiens (Human) - ADAMTSL3 gene extracellular matrix, intracellular membrane-bounded organelle, metalloendopeptidase activity, extracellular matrix organization Indicus|evm.model.CM009511.1.227 P82987 ATL3_HUMAN 79.183 0.975873 0.931402 ADAMTSL3 - ADAMTS-like protein 3 precursor - Homo sapiens (Human) - ADAMTSL3 gene extracellular matrix, intracellular membrane-bounded organelle, metalloendopeptidase activity, extracellular matrix organization Indicus|evm.model.CM009511.1.228 Q99963 SH3G3_HUMAN 94.306 0.915033 0.881844 SH3GL3 - Endophilin-A3 - Homo sapiens (Human) - SH3GL3 gene Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Indicus|evm.model.CM009511.1.229 Q01954 BNC1_HUMAN 83.663 0.997919 0.966801 BNC1 - Zinc finger protein basonuclin-1 - Homo sapiens (Human) - BNC1 gene Transcriptional activator (By similarity). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (PubMed:30010909). May also play a role in the early development of embryos (By similarity). Indicus|evm.model.CM009511.1.230 Q9Y3E1 HDGR3_HUMAN 99.507 0.990196 1.00493 HDGFL3 - Hepatoma-derived growth factor-related protein 3 - Homo sapiens (Human) - HDGFL3 gene Enhances DNA synthesis and may play a role in cell proliferation. Indicus|evm.model.CM009511.1.231 A6QL84 TM6S1_BOVIN 99.412 0.94958 0.964865 TM6SF1 - Transmembrane 6 superfamily member 1 - Bos taurus (Bovine) - TM6SF1 gene May function as sterol isomerase. Indicus|evm.model.CM009511.1.232 Q9H0C5 BTBD1_HUMAN 96.074 0.995868 1.00415 BTBD1 - BTB/POZ domain-containing protein 1 - Homo sapiens (Human) - BTBD1 gene Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). Indicus|evm.model.CM009511.1.233 P68370 TBA1A_RAT 91.106 0.994885 0.866962 Tuba1a - Tubulin alpha-1A chain - Rattus norvegicus (Rat) - Tuba1a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009511.1.234 Q5NVP9 MO4L1_PONAB 98.762 0.993827 1.0031 MORF4L1 - Mortality factor 4-like protein 1 - Pongo abelii (Sumatran orangutan) - MORF4L1 gene Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci (By similarity). Indicus|evm.model.CM009511.1.235 Q3T0I2 CATH_BOVIN 99.701 0.994048 1.00299 CTSH - Pro-cathepsin H precursor - Bos taurus (Bovine) - CTSH gene Important for the overall degradation of proteins in lysosomes. Indicus|evm.model.CM009511.1.236 Q13972 RGRF1_HUMAN 94.266 0.998386 0.973291 RASGRF1 - Ras-specific guanine nucleotide-releasing factor 1 - Homo sapiens (Human) - RASGRF1 gene Promotes the exchange of Ras-bound GDP by GTP. Indicus|evm.model.CM009511.1.237 P0C6C1 AN34C_HUMAN 87.873 0.996269 1.00187 ANKRD34C - Ankyrin repeat domain-containing protein 34C - Homo sapiens (Human) - ANKRD34C gene Indicus|evm.model.CM009511.1.238 Q78IS1 TMED3_MOUSE 90.404 0.899543 0.99095 Tmed3 - Transmembrane emp24 domain-containing protein 3 precursor - Mus musculus (Mouse) - Tmed3 gene Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network (By similarity). Indicus|evm.model.CM009511.1.240 Q9UPX6 MNAR1_HUMAN 90.076 0.997821 1.00218 MINAR1 - Major intrinsically disordered Notch2-binding receptor 1 - Homo sapiens (Human) - MINAR1 gene Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR (PubMed:30080879). Negatively regulates angiogenesis (PubMed:29329397). Negatively regulates cell growth (PubMed:29329397, PubMed:30080879). Negatively regulates neurite outgrowth in hippocampal neurons (By similarity). Indicus|evm.model.CM009511.1.241 Q13309 SKP2_HUMAN 67.123 0.731959 0.457547 SKP2 - S-phase kinase-associated protein 2 - Homo sapiens (Human) - SKP2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Indicus|evm.model.CM009511.1.242 P49914 MTHFS_HUMAN 82.915 0.980198 0.995074 MTHFS - 5-formyltetrahydrofolate cyclo-ligase - Homo sapiens (Human) - MTHFS gene Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. Indicus|evm.model.CM009511.1.243 Q3C2I0 B2LA1_BOVIN 100.000 0.988636 1.00571 BCL2A1 - Bcl-2-related protein A1 - Bos taurus (Bovine) - BCL2A1 gene Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity). Indicus|evm.model.CM009511.1.244 Q0II44 S2541_BOVIN 93.333 0.502825 0.507163 SLC25A41 - Mitochondrial carrier protein SCaMC-3L - Bos taurus (Bovine) - SLC25A41 gene Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane. Indicus|evm.model.CM009511.1.245 Q3SZY7 ZFAN6_BOVIN 99.180 0.952756 0.610577 ZFAND6 - AN1-type zinc finger protein 6 - Bos taurus (Bovine) - ZFAND6 gene polyubiquitin modification-dependent protein binding, protein targeting to peroxisome Indicus|evm.model.CM009511.1.246 A5PKH3 FAAA_BOVIN 100.000 0.995238 1.00239 FAH - Fumarylacetoacetase - Bos taurus (Bovine) - FAH gene fumarylacetoacetase activity, homogentisate catabolic process, L-phenylalanine catabolic process, tyrosine catabolic process Indicus|evm.model.CM009511.1.247 A0A1B0GST9 CTXD1_MOUSE 98.305 0.966667 1.01695 Ctxnd1 - Cortexin domain-containing 1 - Mus musculus (Mouse) - Ctxnd1 gene Indicus|evm.model.CM009511.1.248 Q9HBZ2 ARNT2_HUMAN 95.072 0.586621 0.81311 ARNT2 - Aryl hydrocarbon receptor nuclear translocator 2 - Homo sapiens (Human) - ARNT2 gene Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE). Indicus|evm.model.CM009511.1.249 B5DFK7 AB17C_RAT 97.273 0.60221 0.565625 Abhd17c - Alpha/beta hydrolase domain-containing protein 17C - Rattus norvegicus (Rat) - Abhd17c gene Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Indicus|evm.model.CM009511.1.250 Q5ZJX1 AB17C_CHICK 99.254 0.904762 0.474194 ABHD17C - Alpha/beta hydrolase domain-containing protein 17C - Gallus gallus (Chicken) - ABHD17C gene Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Indicus|evm.model.CM009511.1.251 Q8WUJ3 CEMIP_HUMAN 91.403 0.998532 1.00073 CEMIP - Cell migration-inducing and hyaluronan-binding protein precursor - Homo sapiens (Human) - CEMIP gene Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. Indicus|evm.model.CM009511.1.252 Q3T0U1 MESD_BOVIN 99.569 0.991416 1.00431 MESD - LRP chaperone MESD precursor - Bos taurus (Bovine) - MESD gene Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells. Indicus|evm.model.CM009511.1.253 Q9H1K6 TLRN1_HUMAN 86.726 0.30854 1.00276 TLNRD1 - Talin rod domain-containing protein 1 - Homo sapiens (Human) - TLNRD1 gene Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. Indicus|evm.model.CM009511.1.254 Q6P656 CF161_HUMAN 81.293 0.909938 1.06977 CFAP161 - Cilia- and flagella-associated protein 161 - Homo sapiens (Human) - CFAP161 gene May play a role in motile cilia function, possibly by acting on dynein arm assembly. Indicus|evm.model.CM009511.1.255 Q8WUJ3 CEMIP_HUMAN 44.545 0.854839 0.0911095 CEMIP - Cell migration-inducing and hyaluronan-binding protein precursor - Homo sapiens (Human) - CEMIP gene Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. Indicus|evm.model.CM009511.1.256 Q0V8R5 IL16_BOVIN 100.000 0.464047 2.15152 IL16 - Pro-interleukin-16 - Bos taurus (Bovine) - IL16 gene Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 (By similarity). Indicus|evm.model.CM009511.1.257 A1A4M6 STAR5_BOVIN 100.000 0.990654 1.00469 STARD5 - StAR-related lipid transfer protein 5 - Bos taurus (Bovine) - STARD5 gene May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity). Indicus|evm.model.CM009511.1.258 Q7Z5M5 TMC3_HUMAN 82.636 0.998167 0.991818 TMC3 - Transmembrane channel-like protein 3 - Homo sapiens (Human) - TMC3 gene Probable ion channel. Indicus|evm.model.CM009511.1.259 Q2KIZ3 MCEE_BOVIN 100.000 0.966667 1.02857 MCEE - Methylmalonyl-CoA epimerase, mitochondrial precursor - Bos taurus (Bovine) - MCEE gene Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism. Indicus|evm.model.CM009511.1.260 O00566 MPP10_HUMAN 81.792 0.997089 1.00881 MPHOSPH10 - U3 small nucleolar ribonucleoprotein protein MPP10 - Homo sapiens (Human) - MPHOSPH10 gene Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Indicus|evm.model.CM009511.1.261 D2HNY3 FAN1_AILME 74.316 0.994141 0.999024 FAN1 - Fanconi-associated nuclease 1 - Ailuropoda melanoleuca (Giant panda) - FAN1 gene Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps. Indicus|evm.model.CM009511.1.262 Q9NXD2 MTMRA_HUMAN 87.773 0.997386 0.984556 MTMR10 - Myotubularin-related protein 10 - Homo sapiens (Human) - MTMR10 gene cytoplasm, cytosol, phosphatidylinositol-3-phosphatase activity, phosphatidylinositol dephosphorylation Indicus|evm.model.CM009511.1.263 Q7Z4N2 TRPM1_HUMAN 87.562 0.980344 1.0156 TRPM1 - Transient receptor potential cation channel subfamily M member 1 - Homo sapiens (Human) - TRPM1 gene Forms nonselective divalent cation-conducting channels which mediate the influx of Na(2+), Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization (PubMed:19436059, PubMed:21278253). Impermeable to zinc ions (PubMed:21278253). In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions (PubMed:21278253). Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel. Indicus|evm.model.CM009511.1.265 Q9Y2Y9 KLF13_HUMAN 96.907 0.96 0.347222 KLF13 - Krueppel-like factor 13 - Homo sapiens (Human) - KLF13 gene Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. Indicus|evm.model.CM009511.1.267 P18621 RL17_HUMAN 96.739 0.989189 1.00543 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009511.1.268 Q99767 APBA2_HUMAN 88.845 0.923362 1.08011 APBA2 - Amyloid-beta A4 precursor protein-binding family A member 2 - Homo sapiens (Human) - APBA2 gene Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Indicus|evm.model.CM009511.1.269 O60320 F1891_HUMAN 71.429 0.822581 0.920223 FAM189A1 - Protein FAM189A1 - Homo sapiens (Human) - FAM189A1 gene Indicus|evm.model.CM009511.1.270 Q9CPR8 NSE3_MOUSE 79.570 0.961538 1.02509 Nsmce3 - Non-structural maintenance of chromosomes element 3 homolog - Mus musculus (Mouse) - Nsmce3 gene Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (PubMed:14593116). Indicus|evm.model.CM009511.1.272 O97758 ZO1_CANLF 81.890 0.998828 0.964952 TJP1 - Tight junction protein ZO-1 - Canis lupus familiaris (Dog) - TJP1 gene TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:9792688, PubMed:10575001, PubMed:27802160). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (PubMed:27802160). Plays a role in the regulation of cell migration by targeting CDC42BPBb to the leading edge of migrating cells (By similarity). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (PubMed:24986862). Indicus|evm.model.CM009511.1.276 A6QNM8 SYTC2_BOVIN 99.860 0.888889 1.10635 TARS3 - Threonine--tRNA ligase 2, cytoplasmic - Bos taurus (Bovine) - TARS3 gene Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage. Indicus|evm.model.CM009511.1.277 Q9BRN9 TM2D3_HUMAN 86.111 0.992095 1.02429 TM2D3 - TM2 domain-containing protein 3 precursor - Homo sapiens (Human) - TM2D3 gene spanning component of plasma membrane, lateral inhibition, positive regulation of Notch signaling pathway Indicus|evm.model.CM009511.1.278 Q63415 PCSK6_RAT 90.194 0.997582 0.882604 Pcsk6 - Proprotein convertase subtilisin/kexin type 6 precursor - Rattus norvegicus (Rat) - Pcsk6 gene Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. Indicus|evm.model.CM009511.1.279 Q4R8Y8 RU2A_MACFA 99.216 0.992188 1.00392 SNRPA1 - U2 small nuclear ribonucleoprotein A' - Macaca fascicularis (Crab-eating macaque) - SNRPA1 gene Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. Indicus|evm.model.CM009511.1.280 Q9NQV7 PRDM9_HUMAN 69.751 0.669118 0.456376 PRDM9 - Histone-lysine N-methyltransferase PRDM9 - Homo sapiens (Human) - PRDM9 gene Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:24634223, PubMed:24095733, PubMed:26833727). Also can methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24095733, PubMed:24634223, PubMed:26833727). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (By similarity). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:26833727). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (By similarity). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (By similarity). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (By similarity). In addition performs automethylation (By similarity). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (By similarity). Indicus|evm.model.CM009511.1.281 P54131 ACHA7_BOVIN 97.959 0.992386 0.789579 CHRNA7 - Neuronal acetylcholine receptor subunit alpha-7 precursor - Bos taurus (Bovine) - CHRNA7 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Indicus|evm.model.CM009511.1.282 P54131 ACHA7_BOVIN 100.000 0.655914 0.186373 CHRNA7 - Neuronal acetylcholine receptor subunit alpha-7 precursor - Bos taurus (Bovine) - CHRNA7 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Indicus|evm.model.CM009511.1.284 Q5RBN9 TAD2B_PONAB 76.190 0.957746 0.338095 TADA2B - Transcriptional adapter 2-beta - Pongo abelii (Sumatran orangutan) - TADA2B gene Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. Indicus|evm.model.CM009511.1.286 P82915 RT16_BOVIN 73.636 0.981982 0.822222 MRPS16 - 28S ribosomal protein S16, mitochondrial precursor - Bos taurus (Bovine) - MRPS16 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009511.1.287 Q8TE49 OTU7A_HUMAN 76.749 0.986198 0.860691 OTUD7A - OTU domain-containing protein 7A - Homo sapiens (Human) - OTUD7A gene Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains. Indicus|evm.model.CM009511.1.288 Q8BGE9 RL3R1_MOUSE 49.560 0.784974 0.817797 Rxfp3 - Relaxin-3 receptor 1 - Mus musculus (Mouse) - Rxfp3 gene Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity). Indicus|evm.model.CM009511.1.289 Q9UKP4 ATS7_HUMAN 78.153 0.946497 0.931198 ADAMTS7 - A disintegrin and metalloproteinase with thrombospondin motifs 7 precursor - Homo sapiens (Human) - ADAMTS7 gene Metalloprotease that may play a role in the degradation of COMP. Indicus|evm.model.CM009511.1.290 Q9UPU7 TBD2B_HUMAN 89.387 0.979118 0.895119 TBC1D2B - TBC1 domain family member 2B - Homo sapiens (Human) - TBC1D2B gene May act as a GTPase-activating protein. Indicus|evm.model.CM009511.1.291 A6NKC9 SH2D7_HUMAN 69.414 0.959574 1.04213 SH2D7 - SH2 domain-containing protein 7 - Homo sapiens (Human) - SH2D7 gene Indicus|evm.model.CM009511.1.292 C7A276 CIB2_SHEEP 99.338 0.700935 1.21591 CIB2 - Calcium and integrin-binding family member 2 - Ovis aries (Sheep) - CIB2 gene Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. May be involved in the mechanotransduction process. Indicus|evm.model.CM009511.1.293 P41563 IDH3A_BOVIN 99.727 0.99455 1.00273 IDH3A - Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - IDH3A gene Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Indicus|evm.model.CM009511.1.294 Q2KHW5 ACBG1_BOVIN 99.717 0.95788 1.01377 ACSBG1 - Long-chain-fatty-acid--CoA ligase ACSBG1 - Bos taurus (Bovine) - ACSBG1 gene Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. Indicus|evm.model.CM009511.1.295 Q8WW22 DNJA4_HUMAN 95.184 0.832151 1.06549 DNAJA4 - DnaJ homolog subfamily A member 4 precursor - Homo sapiens (Human) - DNAJA4 gene cytosol, membrane, chaperone binding, unfolded protein binding, negative regulation of endothelial cell migration, negative regulation of inclusion body assembly, positive regulation of gene expression, protein refolding Indicus|evm.model.CM009511.1.296 Q32LN7 WDR61_BOVIN 100.000 0.886297 1.12459 WDR61 - WD repeat-containing protein 61 - Bos taurus (Bovine) - WDR61 gene Cdc73/Paf1 complex, cytoplasm, nucleus, Ski complex, transcriptionally active chromatin, histone H3-K4 trimethylation, negative regulation of myeloid cell differentiation, positive regulation of histone H3-K4 methylation, positive regulation of histone H3-K79 methylation, transcription elongation from RNA polymerase II promoter Indicus|evm.model.CM009511.1.297 P62966 RABP1_RAT 100.000 0.985507 1.0073 Crabp1 - Cellular retinoic acid-binding protein 1 - Rattus norvegicus (Rat) - Crabp1 gene Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. Indicus|evm.model.CM009511.1.298 Q9TSV5 PO5F1_PIG 76.923 0.786207 0.402778 POU5F1 - POU domain, class 5, transcription factor 1 - Sus scrofa (Pig) - POU5F1 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Indicus|evm.model.CM009511.1.299 B3VKQ2 IREB2_PIG 84.751 0.997704 0.903527 IREB2 - Iron-responsive element-binding protein 2 - Sus scrofa (Pig) - IREB2 gene RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. Indicus|evm.model.CM009511.1.300 A5PJU6 HYKK_BOVIN 100.000 0.994695 1.00266 HYKK - Hydroxylysine kinase - Bos taurus (Bovine) - HYKK gene Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine. Indicus|evm.model.CM009511.1.302 P25789 PSA4_HUMAN 100.000 0.992366 1.00383 PSMA4 - Proteasome subunit alpha type-4 - Homo sapiens (Human) - PSMA4 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Indicus|evm.model.CM009511.1.303 Q8SPU7 ACHA5_BOVIN 99.769 0.89605 1.01263 CHRNA5 - Neuronal acetylcholine receptor subunit alpha-5 precursor - Bos taurus (Bovine) - CHRNA5 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Indicus|evm.model.CM009511.1.304 Q07263 ACHA3_BOVIN 99.582 0.915547 1.05253 CHRNA3 - Neuronal acetylcholine receptor subunit alpha-3 precursor - Bos taurus (Bovine) - CHRNA3 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Indicus|evm.model.CM009511.1.305 Q8SPU6 ACHB4_BOVIN 98.387 0.995976 1.00202 CHRNB4 - Neuronal acetylcholine receptor subunit beta-4 precursor - Bos taurus (Bovine) - CHRNB4 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Indicus|evm.model.CM009511.1.306 Q8WVN8 UB2Q2_HUMAN 97.354 0.994709 1.008 UBE2Q2 - Ubiquitin-conjugating enzyme E2 Q2 - Homo sapiens (Human) - UBE2Q2 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Indicus|evm.model.CM009511.1.307 Q78JE5 FBX22_MOUSE 89.031 0.965432 1.00746 Fbxo22 - F-box only protein 22 - Mus musculus (Mouse) - Fbxo22 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Indicus|evm.model.CM009511.1.308 Q2M3C6 TM266_HUMAN 79.406 0.995885 0.915254 TMEM266 - Transmembrane protein 266 - Homo sapiens (Human) - TMEM266 gene Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529). Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529). Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529). Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529). Indicus|evm.model.CM009511.1.309 Q2KJE4 ETFA_BOVIN 99.399 0.994012 1.003 ETFA - Electron transfer flavoprotein subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - ETFA gene Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. Indicus|evm.model.CM009511.1.310 Q96A47 ISL2_HUMAN 98.607 0.994444 1.00279 ISL2 - Insulin gene enhancer protein ISL-2 - Homo sapiens (Human) - ISL2 gene Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Indicus|evm.model.CM009511.1.311 Q9BY12 SCAPE_HUMAN 91.841 0.989607 0.962143 SCAPER - S phase cyclin A-associated protein in the endoplasmic reticulum - Homo sapiens (Human) - SCAPER gene CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. Indicus|evm.model.CM009511.1.312 Q14257 RCN2_HUMAN 88.959 0.993711 1.00315 RCN2 - Reticulocalbin-2 precursor - Homo sapiens (Human) - RCN2 gene Not known. Binds calcium. Indicus|evm.model.CM009511.1.313 O43586 PPIP1_HUMAN 91.106 0.995204 1.0024 PSTPIP1 - Proline-serine-threonine phosphatase-interacting protein 1 - Homo sapiens (Human) - PSTPIP1 gene Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. Indicus|evm.model.CM009511.1.314 Q3SZR9 TSN3_BOVIN 98.729 0.732087 1.26877 TSPAN3 - Tetraspanin-3 - Bos taurus (Bovine) - TSPAN3 gene Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. Indicus|evm.model.CM009511.1.315 Q9H792 PEAK1_HUMAN 90.566 0.998856 1.00115 PEAK1 - Inactive tyrosine-protein kinase PEAK1 - Homo sapiens (Human) - PEAK1 gene Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:23105102, PubMed:20534451). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). Indicus|evm.model.CM009511.1.316 Q9NP66 HM20A_HUMAN 97.983 0.994253 1.00288 HMG20A - High mobility group protein 20A - Homo sapiens (Human) - HMG20A gene Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). Indicus|evm.model.CM009511.1.317 Q96FE5 LIGO1_HUMAN 99.674 0.996748 0.991935 LINGO1 - Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 precursor - Homo sapiens (Human) - LINGO1 gene Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). Indicus|evm.model.CM009511.1.318 Q2KIH8 OD3L1_BOVIN 84.615 0.498182 1.36816 ODF3L1 - Outer dense fiber protein 3-like protein 1 - Bos taurus (Bovine) - ODF3L1 gene cytoskeleton Indicus|evm.model.CM009511.1.319 Q6UVK1 CSPG4_HUMAN 87.037 0.999138 0.999139 CSPG4 - Chondroitin sulfate proteoglycan 4 precursor - Homo sapiens (Human) - CSPG4 gene Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. Indicus|evm.model.CM009511.1.320 Q8WV41 SNX33_HUMAN 94.774 0.996503 0.996516 SNX33 - Sorting nexin-33 - Homo sapiens (Human) - SNX33 gene Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. Indicus|evm.model.CM009511.1.321 Q3T0M3 IMP3_BOVIN 99.457 0.989189 1.00543 IMP3 - U3 small nucleolar ribonucleoprotein protein IMP3 - Bos taurus (Bovine) - IMP3 gene Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). Indicus|evm.model.CM009511.1.322 Q2TBK8 SPN1_BOVIN 99.724 0.935233 1.0663 SNUPN - Snurportin-1 - Bos taurus (Bovine) - SNUPN gene Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Indicus|evm.model.CM009511.1.323 P43378 PTN9_HUMAN 95.819 0.82446 1.17201 PTPN9 - Tyrosine-protein phosphatase non-receptor type 9 - Homo sapiens (Human) - PTPN9 gene Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus. Indicus|evm.model.CM009511.1.324 Q96ST3 SIN3A_HUMAN 98.744 0.998431 1.00157 SIN3A - Paired amphipathic helix protein Sin3a - Homo sapiens (Human) - SIN3A gene Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). Indicus|evm.model.CM009511.1.325 Q9NTJ4 MA2C1_HUMAN 92.690 0.98463 1.00096 MAN2C1 - Alpha-mannosidase 2C1 - Homo sapiens (Human) - MAN2C1 gene Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm. Indicus|evm.model.CM009511.1.326 Q96FI4 NEIL1_HUMAN 86.667 0.994885 1.00256 NEIL1 - Endonuclease 8-like 1 - Homo sapiens (Human) - NEIL1 gene Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Indicus|evm.model.CM009511.1.327 Q5E9V6 COMD4_BOVIN 100.000 0.804082 1.23116 COMMD4 - COMM domain-containing protein 4 - Bos taurus (Bovine) - COMMD4 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Indicus|evm.model.CM009511.1.328 P31948 STIP1_HUMAN 65.487 0.530303 0.364641 STIP1 - Stress-induced-phosphoprotein 1 - Homo sapiens (Human) - STIP1 gene Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). Indicus|evm.model.CM009511.1.329 Q58Y74 TRCG1_MOUSE 51.923 0.719907 0.523636 Trcg1 - Taste receptor cell protein 1 precursor - Mus musculus (Mouse) - Trcg1 gene Indicus|evm.model.CM009511.1.330 Q6ZRI6 CO039_HUMAN 73.265 0.953069 1.05826 C15orf39 - Uncharacterized protein C15orf39 - Homo sapiens (Human) - C15orf39 gene cytosol Indicus|evm.model.CM009511.1.331 Q96CD2 COAC_HUMAN 88.384 0.848485 1.13235 PPCDC - Phosphopantothenoylcysteine decarboxylase - Homo sapiens (Human) - PPCDC gene Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine. Indicus|evm.model.CM009511.1.332 Q17QF8 SCAM5_BOVIN 96.916 0.729032 1.31915 SCAMP5 - Secretory carrier-associated membrane protein 5 - Bos taurus (Bovine) - SCAMP5 gene Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity). Indicus|evm.model.CM009511.1.334 Q9BUL9 RPP25_HUMAN 90.955 0.938389 1.0603 RPP25 - Ribonuclease P protein subunit p25 - Homo sapiens (Human) - RPP25 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). Indicus|evm.model.CM009511.1.335 P00426 COX5A_BOVIN 100.000 0.986928 1.00658 COX5A - Cytochrome c oxidase subunit 5A, mitochondrial precursor - Bos taurus (Bovine) - COX5A gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009511.1.336 Q5XKK7 F219B_HUMAN 86.364 0.989583 0.969697 FAM219B - Protein FAM219B - Homo sapiens (Human) - FAM219B gene Indicus|evm.model.CM009511.1.337 Q3SZI0 MPI_BOVIN 100.000 0.501129 1.04728 MPI - Mannose-6-phosphate isomerase - Bos taurus (Bovine) - MPI gene Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. Indicus|evm.model.CM009511.1.338 O15127 SCAM2_HUMAN 81.720 0.994624 1.1307 SCAMP2 - Secretory carrier-associated membrane protein 2 - Homo sapiens (Human) - SCAMP2 gene Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. Indicus|evm.model.CM009511.1.339 Q6PHR2 ULK3_HUMAN 97.246 0.995772 1.00212 ULK3 - Serine/threonine-protein kinase ULK3 - Homo sapiens (Human) - ULK3 gene Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. Indicus|evm.model.CM009511.1.340 Q0IIE0 CPLX3_BOVIN 99.367 0.987421 1.00633 CPLX3 - Complexin-3 precursor - Bos taurus (Bovine) - CPLX3 gene Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). Indicus|evm.model.CM009511.1.341 Q9HAT1 LMA1L_HUMAN 70.076 0.99604 0.960076 LMAN1L - Protein ERGIC-53-like precursor - Homo sapiens (Human) - LMAN1L gene collagen-containing extracellular matrix, COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, Golgi membrane, mannose binding, endoplasmic reticulum organization, endoplasmic reticulum to Golgi vesicle-mediated transport, Golgi organization Indicus|evm.model.CM009511.1.342 Q0VBZ0 CSK_BOVIN 100.000 0.995565 1.00222 CSK - Tyrosine-protein kinase CSK - Bos taurus (Bovine) - CSK gene Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). Indicus|evm.model.CM009511.1.343 Q3LFT9 CP1A2_BALAC 85.465 0.996132 1.00194 CYP1A2 - Cytochrome P450 1A2 - Balaenoptera acutorostrata (Common minke whale) - CYP1A2 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation. Indicus|evm.model.CM009511.1.344 P56591 CP1A1_SHEEP 94.186 0.996132 0.996146 CYP1A1 - Cytochrome P450 1A1 - Ovis aries (Sheep) - CYP1A1 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Indicus|evm.model.CM009511.1.345 Q5RDU9 EDC3_PONAB 97.441 0.996071 1.00197 EDC3 - Enhancer of mRNA-decapping protein 3 - Pongo abelii (Sumatran orangutan) - EDC3 gene Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity). Indicus|evm.model.CM009511.1.346 Q3SX21 CLK3_BOVIN 100.000 0.995927 1.00204 CLK3 - Dual specificity protein kinase CLK3 - Bos taurus (Bovine) - CLK3 gene Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity). Indicus|evm.model.CM009511.1.347 Q8IVW6 ARI3B_HUMAN 89.890 0.967568 0.989305 ARID3B - AT-rich interactive domain-containing protein 3B - Homo sapiens (Human) - ARID3B gene Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. Indicus|evm.model.CM009511.1.348 Q01105 SET_HUMAN 86.047 0.193548 0.748276 SET - Protein SET - Homo sapiens (Human) - SET gene Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Indicus|evm.model.CM009511.1.349 Q2KIS3 UBL7_BOVIN 99.737 0.938119 1.06316 UBL7 - Ubiquitin-like protein 7 - Bos taurus (Bovine) - UBL7 gene cytosol, polyubiquitin modification-dependent protein binding, ubiquitin-dependent protein catabolic process Indicus|evm.model.CM009511.1.350 O75326 SEM7A_HUMAN 82.883 0.996992 0.998498 SEMA7A - Semaphorin-7A precursor - Homo sapiens (Human) - SEMA7A gene Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. Indicus|evm.model.CM009511.1.352 P00189 CP11A_BOVIN 99.535 0.964045 0.855769 CYP11A1 - Cholesterol side-chain cleavage enzyme, mitochondrial precursor - Bos taurus (Bovine) - CYP11A1 gene A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:11412116). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:11412116). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:11412116). Indicus|evm.model.CM009511.1.353 Q8N5R6 CCD33_HUMAN 77.899 0.907285 0.31524 CCDC33 - Coiled-coil domain-containing protein 33 - Homo sapiens (Human) - CCDC33 gene peroxisome Indicus|evm.model.CM009511.1.354 Q8N5R6 CCD33_HUMAN 52.500 0.721612 0.284969 CCDC33 - Coiled-coil domain-containing protein 33 - Homo sapiens (Human) - CCDC33 gene peroxisome Indicus|evm.model.CM009511.1.355 Q0V8E7 STRA6_BOVIN 100.000 0.99701 1.0015 STRA6 - Receptor for retinol uptake STRA6 - Bos taurus (Bovine) - STRA6 gene Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:17255476, PubMed:18419130). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid (By similarity). Indicus|evm.model.CM009511.1.356 A4IFA6 ISLR_BOVIN 100.000 0.995338 1.00234 ISLR - Immunoglobulin superfamily containing leucine-rich repeat protein precursor - Bos taurus (Bovine) - ISLR gene Indicus|evm.model.CM009511.1.357 Q6UXK2 ISLR2_HUMAN 90.000 0.997337 1.00805 ISLR2 - Immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor - Homo sapiens (Human) - ISLR2 gene Required for axon extension during neural development. Indicus|evm.model.CM009511.1.358 P29590 PML_HUMAN 75.596 0.994266 0.988662 PML - Protein PML - Homo sapiens (Human) - PML gene Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. Indicus|evm.model.CM009511.1.359 Q9UBI4 STML1_HUMAN 91.206 0.994987 1.00251 STOML1 - Stomatin-like protein 1 - Homo sapiens (Human) - STOML1 gene May play a role in cholesterol transfer to late endosomes (PubMed:19696025). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation (PubMed:23082202). Indicus|evm.model.CM009511.1.360 Q95L39 LOXL1_BOVIN 99.493 0.996627 1.00338 LOXL1 - Lysyl oxidase homolog 1 precursor - Bos taurus (Bovine) - LOXL1 gene Active on elastin and collagen substrates. Indicus|evm.model.CM009511.1.361 P79204 MCPT2_SHEEP 87.554 0.935484 1.00813 Mast cell protease 2 precursor - Ovis aries (Sheep) Indicus|evm.model.CM009511.1.362 P79204 MCPT2_SHEEP 90.043 0.839416 1.11382 Mast cell protease 2 precursor - Ovis aries (Sheep) Indicus|evm.model.CM009511.1.363 P80219 DDN1_BOVIN 99.602 0.992063 1.00398 BDMD1 - Duodenase-1 precursor - Bos taurus (Bovine) - BDMD1 gene Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues. Indicus|evm.model.CM009511.1.364 P80219 DDN1_BOVIN 75.269 0.494624 1.48207 BDMD1 - Duodenase-1 precursor - Bos taurus (Bovine) - BDMD1 gene Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues. Indicus|evm.model.CM009511.1.365 P28293 CATG_MOUSE 68.122 0.904762 0.965517 Ctsg - Cathepsin G precursor - Mus musculus (Mouse) - Ctsg gene This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. Indicus|evm.model.CM009511.1.366 P28293 CATG_MOUSE 65.351 0.900794 0.965517 Ctsg - Cathepsin G precursor - Mus musculus (Mouse) - Ctsg gene This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. Indicus|evm.model.CM009511.1.367 Q63610 TPM3_RAT 81.743 0.985646 0.842742 Tpm3 - Tropomyosin alpha-3 chain - Rattus norvegicus (Rat) - Tpm3 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Indicus|evm.model.CM009511.1.368 P20718 GRAH_HUMAN 76.793 0.940239 1.02033 GZMH - Granzyme H precursor - Homo sapiens (Human) - GZMH gene Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. Indicus|evm.model.CM009511.1.370 O46683 MCPT3_SHEEP 61.181 0.92887 0.952191 Mast cell protease 3 precursor - Ovis aries (Sheep) Indicus|evm.model.CM009511.1.371 P10144 GRAB_HUMAN 73.061 0.983806 1 GZMB - Granzyme B precursor - Homo sapiens (Human) - GZMB gene Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3262682, PubMed:3263427, PubMed:1985927). It cleaves after Asp (PubMed:8258716, PubMed:1985927). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed:32188940, PubMed:31953257). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (PubMed:9852092). Indicus|evm.model.CM009511.1.372 Q8R3T5 STXB6_MOUSE 99.524 0.990521 1.00476 Stxbp6 - Syntaxin-binding protein 6 - Mus musculus (Mouse) - Stxbp6 gene Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis. Indicus|evm.model.CM009511.1.375 P51513 NOVA1_HUMAN 99.803 0.996063 1.00197 NOVA1 - RNA-binding protein Nova-1 - Homo sapiens (Human) - NOVA1 gene May regulate RNA splicing or metabolism in a specific subset of developing neurons. Indicus|evm.model.CM009511.1.377 P02552 TBA1_CHICK 75.105 0.818182 0.614078 Tubulin alpha-1 chain - Gallus gallus (Chicken) Indicus|evm.model.CM009511.1.379 P55316 FOXG1_HUMAN 100.000 0.933718 0.709611 FOXG1 - Forkhead box protein G1 - Homo sapiens (Human) - FOXG1 gene Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. Indicus|evm.model.CM009511.1.380 Q15139 KPCD1_HUMAN 92.271 0.997561 0.899123 PRKD1 - Serine/threonine-protein kinase D1 - Homo sapiens (Human) - PRKD1 gene Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). Indicus|evm.model.CM009511.1.381 Q5R4D4 NP1L1_PONAB 94.340 0.972222 0.276215 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Pongo abelii (Sumatran orangutan) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009511.1.382 A6H767 NP1L1_BOVIN 95.513 0.987179 0.398977 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009511.1.383 O02751 CFDP2_BOVIN 79.688 0.561947 0.381757 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Indicus|evm.model.CM009511.1.384 Q7L622 G2E3_HUMAN 86.648 0.962963 1.03258 G2E3 - G2/M phase-specific E3 ubiquitin-protein ligase - Homo sapiens (Human) - G2E3 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death. Indicus|evm.model.CM009511.1.385 Q8WVM8 SCFD1_HUMAN 97.809 0.993769 1 SCFD1 - Sec1 family domain-containing protein 1 - Homo sapiens (Human) - SCFD1 gene Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). Indicus|evm.model.CM009511.1.387 Q5EA64 COCH_BOVIN 99.818 0.99637 1.00182 COCH - Cochlin precursor - Bos taurus (Bovine) - COCH gene Plays a role in the control of cell shape and motility in the trabecular meshwork. Indicus|evm.model.CM009511.1.388 A5D7H2 STRN3_BOVIN 100.000 0.997494 1.00125 STRN3 - Striatin-3 - Bos taurus (Bovine) - STRN3 gene Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity). Indicus|evm.model.CM009511.1.389 Q3ZBB6 AP4S1_BOVIN 98.095 0.852459 0.847222 AP4S1 - AP-4 complex subunit sigma-1 - Bos taurus (Bovine) - AP4S1 gene Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal. Indicus|evm.model.CM009511.1.390 Q9ULT8 HECD1_HUMAN 99.655 0.999234 1.00038 HECTD1 - E3 ubiquitin-protein ligase HECTD1 - Homo sapiens (Human) - HECTD1 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure. Indicus|evm.model.CM009511.1.391 Q86XA9 HTR5A_HUMAN 92.473 0.999022 1.00294 HEATR5A - HEAT repeat-containing protein 5A - Homo sapiens (Human) - HEATR5A gene endocytic vesicle, endocytosis, protein localization, retrograde transport, endosome to Golgi Indicus|evm.model.CM009511.1.392 Q96FN9 DTD2_HUMAN 89.286 0.988166 1.00595 DTD2 - D-aminoacyl-tRNA deacylase 2 - Homo sapiens (Human) - DTD2 gene Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity). Indicus|evm.model.CM009511.1.393 Q49SQ3 GPR33_PANTR 78.733 0.956522 0.690691 GPR33 - Probable G-protein coupled receptor 33 - Pan troglodytes (Chimpanzee) - GPR33 gene Orphan receptor; could be a chemoattractant receptor. Indicus|evm.model.CM009511.1.394 Q8TB37 NUBPL_HUMAN 90.596 0.957831 1.04075 NUBPL - Iron-sulfur protein NUBPL precursor - Homo sapiens (Human) - NUBPL gene Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits. Indicus|evm.model.CM009511.1.395 Q13017 RHG05_HUMAN 98.868 0.503926 0.932756 ARHGAP5 - Rho GTPase-activating protein 5 - Homo sapiens (Human) - ARHGAP5 gene GTPase-activating protein for Rho family members (PubMed:8537347). Indicus|evm.model.CM009511.1.397 Q13023 AKAP6_HUMAN 87.037 0.999138 1.00043 AKAP6 - A-kinase anchor protein 6 - Homo sapiens (Human) - AKAP6 gene Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. Indicus|evm.model.CM009511.1.398 Q8IXF0 NPAS3_HUMAN 94.588 0.997509 0.860665 NPAS3 - Neuronal PAS domain-containing protein 3 - Homo sapiens (Human) - NPAS3 gene May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). Indicus|evm.model.CM009511.1.399 Q9H6Z9 EGLN3_HUMAN 97.500 0.85 0.585774 EGLN3 - Prolyl hydroxylase EGLN3 - Homo sapiens (Human) - EGLN3 gene Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as PKM, TELO2, ATF4 and HIF1A (PubMed:19584355, PubMed:21620138, PubMed:21483450, PubMed:22797300, PubMed:20978507, PubMed:21575608). Target proteins are preferentially recognized via a LXXLAP motif. Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12181324). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12181324). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12181324). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12181324). Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site (PubMed:11595184, PubMed:12181324). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12181324). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12181324). ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis (PubMed:21620138, PubMed:21483450). Under normoxia, hydroxylates and regulates the stability of ADRB2 (PubMed:19584355). Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex (PubMed:20849813). In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity (PubMed:16098468). Also essential for hypoxic regulation of neutrophilic inflammation (PubMed:21317538). Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway (PubMed:22797300). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (Probable). Indicus|evm.model.CM009511.1.400 Q2TBQ5 RL7A_BOVIN 79.681 0.930328 0.917293 RPL7A - 60S ribosomal protein L7a - Bos taurus (Bovine) - RPL7A gene cytosolic large ribosomal subunit, RNA binding, maturation of LSU-rRNA Indicus|evm.model.CM009511.1.401 Q969W0 SPTSA_HUMAN 100.000 0.971014 0.971831 SPTSSA - Serine palmitoyltransferase small subunit A - Homo sapiens (Human) - SPTSSA gene Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19416851). Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI) (PubMed:23510452). Indicus|evm.model.CM009511.1.402 P62752 RL23A_RAT 98.810 0.976471 0.544872 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009511.1.403 Q56P03 EAPP_HUMAN 90.526 0.96587 1.02807 EAPP - E2F-associated phosphoprotein - Homo sapiens (Human) - EAPP gene May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. Indicus|evm.model.CM009511.1.404 P10301 RRAS_HUMAN 94.872 0.22619 0.770642 RRAS - Ras-related protein R-Ras precursor - Homo sapiens (Human) - RRAS gene Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). Indicus|evm.model.CM009511.1.406 Q5R613 SNX6_PONAB 99.742 0.93932 1.01478 SNX6 - Sorting nexin-6 - Pongo abelii (Sumatran orangutan) - SNX6 gene Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation. In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B. May contribute to transcription regulation (By similarity). Indicus|evm.model.CM009511.1.407 Q5RAI8 CPSF5_PONAB 87.356 0.664062 0.563877 NUDT21 - Cleavage and polyadenylation specificity factor subunit 5 - Pongo abelii (Sumatran orangutan) - NUDT21 gene Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7. Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function. Binds to chromatin. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. Indicus|evm.model.CM009511.1.408 Q5G6V9 COF2_PIG 100.000 0.988024 1.00602 CFL2 - Cofilin-2 - Sus scrofa (Pig) - CFL2 gene Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). Indicus|evm.model.CM009511.1.409 Q9NRL2 BAZ1A_HUMAN 93.553 0.997203 0.919023 BAZ1A - Bromodomain adjacent to zinc finger domain protein 1A - Homo sapiens (Human) - BAZ1A gene Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. Indicus|evm.model.CM009511.1.410 Q9NRL2 BAZ1A_HUMAN 96.947 0.984848 0.0848329 BAZ1A - Bromodomain adjacent to zinc finger domain protein 1A - Homo sapiens (Human) - BAZ1A gene Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. Indicus|evm.model.CM009511.1.412 Q5R4R6 SRP54_PONAB 100.000 0.99604 1.00198 SRP54 - Signal recognition particle 54 kDa protein - Pongo abelii (Sumatran orangutan) - SRP54 gene Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development. Indicus|evm.model.CM009511.1.413 P24049 RL17_RAT 77.174 0.987179 0.847826 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009511.1.414 A6QLZ5 F177A_BOVIN 100.000 0.894068 1.11321 FAM177A1 - Protein FAM177A1 - Bos taurus (Bovine) - FAM177A1 gene Indicus|evm.model.CM009511.1.415 Q5E9G1 P2R3C_BOVIN 100.000 0.995595 1.00221 PPP2R3C - Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma - Bos taurus (Bovine) - PPP2R3C gene May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells. Indicus|evm.model.CM009511.1.416 Q4R366 MRPP3_MACFA 80.137 0.960461 1.04475 PRORP - Mitochondrial ribonuclease P catalytic subunit precursor - Macaca fascicularis (Crab-eating macaque) - PRORP gene Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends. Indicus|evm.model.CM009511.1.417 P60901 PSA6_RAT 100.000 0.964912 0.926829 Psma6 - Proteasome subunit alpha type-6 - Rattus norvegicus (Rat) - Psma6 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Indicus|evm.model.CM009511.1.418 Q08353 IKBA_PIG 99.045 0.993651 1.00318 NFKBIA - NF-kappa-B inhibitor alpha - Sus scrofa (Pig) - NFKBIA gene Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. Indicus|evm.model.CM009511.1.419 Q96T92 INSM2_HUMAN 84.656 0.996396 0.980565 INSM2 - Insulinoma-associated protein 2 - Homo sapiens (Human) - INSM2 gene May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. Indicus|evm.model.CM009511.1.420 P86409 RGPA1_PIG 99.703 0.12973 7.68546 RALGAPA1 - Ral GTPase-activating protein subunit alpha-1 - Sus scrofa (Pig) - RALGAPA1 gene Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. Indicus|evm.model.CM009511.1.421 Q5PSV4 BRM1L_HUMAN 93.064 0.994236 1.0743 BRMS1L - Breast cancer metastasis-suppressor 1-like protein - Homo sapiens (Human) - BRMS1L gene Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth. Indicus|evm.model.CM009511.1.422 Q9NS73 MBIP1_HUMAN 89.535 0.994203 1.00291 MBIP - MAP3K12-binding inhibitory protein 1 - Homo sapiens (Human) - MBIP gene Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Indicus|evm.model.CM009511.1.423 P19133 FRIL_PIG 67.949 0.539007 1.80769 FTL - Ferritin light chain - Sus scrofa (Pig) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009511.1.424 P43698 TITF1_CANLF 97.849 0.994609 1 TITF1 - Thyroid transcription factor 1 - Canis lupus familiaris (Dog) - TITF1 gene Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Indicus|evm.model.CM009511.1.425 O15522 NKX28_HUMAN 89.024 0.519108 1.31381 NKX2-8 - Homeobox protein Nkx-2.8 - Homo sapiens (Human) - NKX2-8 gene chromatin, nucleus, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, cell differentiation Indicus|evm.model.CM009511.1.426 Q9GZP4 PITH1_HUMAN 74.026 0.95 0.379147 PITHD1 - PITH domain-containing protein 1 - Homo sapiens (Human) - PITHD1 gene Promotes megakaryocyte differentiation by up-regulating RUNX1 expression (PubMed:25134913). Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene (PubMed:25134913). Indicus|evm.model.CM009511.1.428 Q2VL51 PAX9_LEPED 98.830 0.994169 1.00587 PAX9 - Paired box protein Pax-9 - Lepilemur edwardsi (Milne-Edwards's sportive lemur) - PAX9 gene Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. Indicus|evm.model.CM009511.1.429 A0JN87 ODC_BOVIN 99.167 0.901887 0.886288 SLC25A21 - Mitochondrial 2-oxodicarboxylate carrier - Bos taurus (Bovine) - SLC25A21 gene Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate. Indicus|evm.model.CM009511.1.431 Q8TD10 MIPO1_HUMAN 85.520 0.995485 1.00226 MIPOL1 - Mirror-image polydactyly gene 1 protein - Homo sapiens (Human) - MIPOL1 gene nucleus, identical protein binding Indicus|evm.model.CM009511.1.432 P35582 FOXA1_MOUSE 93.584 0.786713 1.22222 Foxa1 - Hepatocyte nuclear factor 3-alpha - Mus musculus (Mouse) - Foxa1 gene Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, lungs and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles. Plays a role in prostate morphogenesis and epithelial cell differentiation. FOXA1 and FOXA2 are essential for hepatic specification. FOXA1 and FOXA2 are required for morphogenesis and cell differentiation during formation of the lung. FOXA1 and FOXA2 are involved in bile duct formation; they positively regulate the binding of glucocorticoid receptor/NR3C1 to the IL6 promoter. FOXA1 and FOXA2 regulate multiple phases of midbrain dopaminergic neuron development; they regulate expression of NEUROG2 at the beginning of mDA neurogenesis and of NR4A2 and EN1 in immature mDA neurons. Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription. Inhibits NKX2-1-mediated transcription from the SFTPC promoter in lung epithel independently from DNA-binding. Involved in regulation of apoptosis. Involved in cell cycle regulation. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates the GCG promoter. Indicus|evm.model.CM009511.1.433 Q86TZ1 TTC6_HUMAN 84.500 0.207058 3.70577 TTC6 - Tetratricopeptide repeat protein 6 - Homo sapiens (Human) - TTC6 gene Indicus|evm.model.CM009511.1.435 P30872 SSR1_HUMAN 99.744 0.994885 1 SSTR1 - Somatostatin receptor type 1 - Homo sapiens (Human) - SSTR1 gene Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Indicus|evm.model.CM009511.1.436 Q86T13 CLC14_HUMAN 74.082 0.99389 1.00204 CLEC14A - C-type lectin domain family 14 member A precursor - Homo sapiens (Human) - CLEC14A gene collagen-containing extracellular matrix, external side of plasma membrane, extracellular matrix binding, extracellular matrix protein binding, cell migration, vascular endothelial growth factor receptor-2 signaling pathway, vascular endothelial growth factor receptor-3 signaling pathway Indicus|evm.model.CM009511.1.438 A2VDL8 SC23A_BOVIN 100.000 0.988251 0.997396 SEC23A - Protein transport protein Sec23A - Bos taurus (Bovine) - SEC23A gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane. Indicus|evm.model.CM009511.1.439 O14893 GEMI2_HUMAN 93.929 0.992883 1.00357 GEMIN2 - Gem-associated protein 2 - Homo sapiens (Human) - GEMIN2 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Indicus|evm.model.CM009511.1.440 Q86SZ2 TPC6B_HUMAN 100.000 0.987421 1.00633 TRAPPC6B - Trafficking protein particle complex subunit 6B - Homo sapiens (Human) - TRAPPC6B gene Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (PubMed:16025134, PubMed:16828797). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable). Indicus|evm.model.CM009511.1.441 Q5R5X0 PININ_PONAB 93.075 0.99723 1.00417 PNN - Pinin - Pongo abelii (Sumatran orangutan) - PNN gene Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion (By similarity). Indicus|evm.model.CM009511.1.442 Q96PC5 MIA2_HUMAN 71.677 0.979751 0.454674 MIA2 - Melanoma inhibitory activity protein 2 precursor - Homo sapiens (Human) - MIA2 gene Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:27138255, PubMed:21525241, PubMed:25202031, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). Indicus|evm.model.CM009511.1.443 Q96PC5 MIA2_HUMAN 86.445 0.970075 0.567989 MIA2 - Melanoma inhibitory activity protein 2 precursor - Homo sapiens (Human) - MIA2 gene Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:27138255, PubMed:21525241, PubMed:25202031, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). Indicus|evm.model.CM009511.1.444 Q7Z6M2 FBX33_HUMAN 95.179 0.996435 1.01081 FBXO33 - F-box only protein 33 - Homo sapiens (Human) - FBXO33 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity). Indicus|evm.model.CM009511.1.445 P27117 DCOR_BOVIN 74.400 0.473684 0.535792 ODC1 - Ornithine decarboxylase - Bos taurus (Bovine) - ODC1 gene Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Indicus|evm.model.CM009511.1.447 P61291 PSME3_PIG 74.000 0.960784 0.200787 PSME3 - Proteasome activator complex subunit 3 - Sus scrofa (Pig) - PSME3 gene Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity). Indicus|evm.model.CM009511.1.448 Q96NI6 LRFN5_HUMAN 96.662 0.997214 0.998609 LRFN5 - Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor - Homo sapiens (Human) - LRFN5 gene Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons. Indicus|evm.model.CM009511.1.449 Q6UVY6 MOXD1_HUMAN 89.841 0.948767 0.859706 MOXD1 - DBH-like monooxygenase protein 1 precursor - Homo sapiens (Human) - MOXD1 gene endoplasmic reticulum membrane, extracellular space, secretory granule membrane, copper ion binding, dopamine beta-monooxygenase activity, dopamine catabolic process, norepinephrine biosynthetic process, octopamine biosynthetic process Indicus|evm.model.CM009511.1.450 O75928 PIAS2_HUMAN 69.620 0.997462 0.634461 PIAS2 - E3 SUMO-protein ligase PIAS2 - Homo sapiens (Human) - PIAS2 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'. Indicus|evm.model.CM009511.1.451 Q8C5D8 PIAS2_MOUSE 87.879 0.633663 0.162641 Pias2 - E3 SUMO-protein ligase PIAS2 - Mus musculus (Mouse) - Pias2 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIASx-beta, but not isoform PIASx-alpha, promotes MDM2 sumoylation. Isoform PIASx-alpha promotes PARK7 sumoylation. Isoform PIASx-beta promotes NCOA2 sumoylation more efficiently than isoform PIASx-alpha (By similarity). Sumoylates PML at'Lys-65' and 'Lys-160' (By similarity). Indicus|evm.model.CM009511.1.453 P63170 DYL1_RAT 98.876 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Indicus|evm.model.CM009511.1.454 Q2T9N0 FSCB_BOVIN 99.389 0.997558 1.00122 FSCB - Fibrous sheath CABYR-binding protein - Bos taurus (Bovine) - FSCB gene May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium. Indicus|evm.model.CM009511.1.455 A4FUH0 RL22L_BOVIN 79.508 0.72 1.22951 RPL22L1 - 60S ribosomal protein L22-like 1 - Bos taurus (Bovine) - RPL22L1 gene RNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009511.1.457 Q4W4Y0 CN028_HUMAN 98.065 0.993569 1.00323 C14orf28 - Uncharacterized protein C14orf28 - Homo sapiens (Human) - C14orf28 gene Indicus|evm.model.CM009511.1.458 Q9NXS3 KLH28_HUMAN 98.949 0.996503 1.00175 KLHL28 - Kelch-like protein 28 - Homo sapiens (Human) - KLHL28 gene Indicus|evm.model.CM009511.1.459 P49401 RS4_XENLA 87.500 0.166667 0.524715 rps4 - 40S ribosomal protein S4 - Xenopus laevis (African clawed frog) - rps4 gene Indicus|evm.model.CM009511.1.460 Q9Y4F4 TGRM1_HUMAN 84.126 0.990104 1.05756 TOGARAM1 - TOG array regulator of axonemal microtubules protein 1 - Homo sapiens (Human) - TOGARAM1 gene Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). Indicus|evm.model.CM009511.1.461 Q86UA1 PRP39_HUMAN 95.516 0.997006 0.998505 PRPF39 - Pre-mRNA-processing factor 39 - Homo sapiens (Human) - PRPF39 gene Involved in pre-mRNA splicing. Indicus|evm.model.CM009511.1.462 P26884 FKBP3_BOVIN 100.000 0.906504 1.09821 FKBP3 - Peptidyl-prolyl cis-trans isomerase FKBP3 - Bos taurus (Bovine) - FKBP3 gene FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two dinstinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. Indicus|evm.model.CM009511.1.463 Q8IYD8 FANCM_HUMAN 74.490 0.998509 0.982422 FANCM - Fanconi anemia group M protein - Homo sapiens (Human) - FANCM gene DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). Indicus|evm.model.CM009511.1.464 Q6P0N0 M18BP_HUMAN 74.107 0.248009 0.776502 MIS18BP1 - Mis18-binding protein 1 - Homo sapiens (Human) - MIS18BP1 gene Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Indicus|evm.model.CM009511.1.465 Q32KN9 PRLD1_BOVIN 56.872 0.948148 0.616438 PRELID1 - PRELI domain-containing protein 1, mitochondrial precursor - Bos taurus (Bovine) - PRELID1 gene Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs (By similarity). Indicus|evm.model.CM009511.1.466 O43548 TGM5_HUMAN 85.615 0.994413 0.994444 TGM5 - Protein-glutamine gamma-glutamyltransferase 5 - Homo sapiens (Human) - TGM5 gene Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes. Indicus|evm.model.CM009511.1.467 Q96PF1 TGM7_HUMAN 82.320 0.950202 1.04648 TGM7 - Protein-glutamine gamma-glutamyltransferase Z - Homo sapiens (Human) - TGM7 gene Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Indicus|evm.model.CM009511.1.468 O60294 TYW4_HUMAN 81.633 0.997085 1 LCMT2 - tRNA wybutosine-synthesizing protein 4 - Homo sapiens (Human) - LCMT2 gene Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. Indicus|evm.model.CM009511.1.469 P24049 RL17_RAT 100.000 0.989189 1.00543 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009511.1.470 Q0VC13 ADAL_BOVIN 100.000 0.994318 1.00285 ADAL - Adenosine deaminase-like protein - Bos taurus (Bovine) - ADAL gene Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A). Indicus|evm.model.CM009511.1.471 Q8IWY8 ZSC29_HUMAN 87.222 0.997647 0.997653 ZSCAN29 - Zinc finger and SCAN domain-containing protein 29 - Homo sapiens (Human) - ZSCAN29 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009511.1.472 Q9UGJ1 GCP4_HUMAN 98.801 0.997001 1 TUBGCP4 - Gamma-tubulin complex component 4 - Homo sapiens (Human) - TUBGCP4 gene Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Indicus|evm.model.CM009511.1.473 Q12888 TP53B_HUMAN 87.278 0.996441 0.997465 TP53BP1 - TP53-binding protein 1 - Homo sapiens (Human) - TP53BP1 gene Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). Indicus|evm.model.CM009511.1.474 P14401 ENP2_TETCF 80.240 0.106628 8.92286 Electromotor neuron-associated protein 2 - Tetronarce californica (Pacific electric ray) Indicus|evm.model.CM009511.1.475 A7Z050 VIP1_BOVIN 99.932 0.998647 1.00068 PPIP5K1 - Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 - Bos taurus (Bovine) - PPIP5K1 gene Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. Indicus|evm.model.CM009511.1.476 Q9TTK8 KCRU_BOVIN 100.000 0.995204 1.0024 CKMT1 - Creatine kinase U-type, mitochondrial precursor - Bos taurus (Bovine) - CKMT1 gene Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). Indicus|evm.model.CM009511.1.477 Q7RTU9 STRC_HUMAN 90.479 0.998867 0.994366 STRC - Stereocilin precursor - Homo sapiens (Human) - STRC gene Essential to the formation of horizontal top connectors between outer hair cell stereocilia. Indicus|evm.model.CM009511.1.478 A2ARP9 CTSR2_MOUSE 80.109 0.653571 0.952381 Catsper2 - Cation channel sperm-associated protein 2 - Mus musculus (Mouse) - Catsper2 gene Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Indicus|evm.model.CM009511.1.479 P38657 PDIA3_BOVIN 99.802 0.996047 1.00198 PDIA3 - Protein disulfide-isomerase A3 precursor - Bos taurus (Bovine) - PDIA3 gene endoplasmic reticulum, positive regulation of apoptotic process Indicus|evm.model.CM009511.1.480 F1MGG3 ELL3_BOVIN 100.000 0.994949 1.00253 ELL3 - RNA polymerase II elongation factor ELL3 - Bos taurus (Bovine) - ELL3 gene Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Indicus|evm.model.CM009511.1.481 Q5R7C4 SERF2_PONAB 94.915 0.865672 1.13559 SERF2 - Small EDRK-rich factor 2 - Pongo abelii (Sumatran orangutan) - SERF2 gene Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (By similarity). Indicus|evm.model.CM009511.1.482 A6NH21 SERC4_HUMAN 85.656 0.979839 0.957529 SERINC4 - Serine incorporator 4 - Homo sapiens (Human) - SERINC4 gene Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. Indicus|evm.model.CM009511.1.483 Q9CR41 HYPK_MOUSE 100.000 0.983607 0.945736 Hypk - Huntingtin-interacting protein K - Mus musculus (Mouse) - Hypk gene Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N-terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity). Indicus|evm.model.CM009511.1.484 Q5EA98 MFAP1_BOVIN 100.000 0.995455 1.00228 MFAP1 - Microfibrillar-associated protein 1 - Bos taurus (Bovine) - MFAP1 gene Involved in pre-mRNA splicing as a component of the spliceosome. Indicus|evm.model.CM009511.1.485 B2KIQ4 WDR76_RHIFE 80.476 0.996815 0.996825 WDR76 - WD repeat-containing protein 76 - Rhinolophus ferrumequinum (Greater horseshoe bat) - WDR76 gene Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Indicus|evm.model.CM009511.1.486 Q7Z6J6 FRMD5_HUMAN 98.246 0.996497 1.00175 FRMD5 - FERM domain-containing protein 5 - Homo sapiens (Human) - FRMD5 gene May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). Indicus|evm.model.CM009511.1.488 O46685 OGR1_BOVIN 100.000 0.994475 1.00277 GPR68 - Ovarian cancer G-protein coupled receptor 1 - Bos taurus (Bovine) - GPR68 gene Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Also functions as a metastasis suppressor gene in prostate cancer (By similarity). Indicus|evm.model.CM009511.1.489 Q9P219 DAPLE_HUMAN 84.079 0.999014 1.00049 CCDC88C - Protein Daple - Homo sapiens (Human) - CCDC88C gene Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). Indicus|evm.model.CM009511.1.490 Q6P2K6 P4R3A_MOUSE 98.780 0.997564 1.00122 Ppp4r3a - Serine/threonine-protein phosphatase 4 regulatory subunit 3A - Mus musculus (Mouse) - Ppp4r3a gene Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair (By similarity). Indicus|evm.model.CM009511.1.492 Q3T0Q8 UT14A_BOVIN 95.255 0.961268 0.368831 UTP14A - U3 small nucleolar RNA-associated protein 14 homolog A - Bos taurus (Bovine) - UTP14A gene May be required for ribosome biogenesis. Indicus|evm.model.CM009511.1.493 Q3T0Q8 UT14A_BOVIN 93.319 0.995833 0.623377 UTP14A - U3 small nucleolar RNA-associated protein 14 homolog A - Bos taurus (Bovine) - UTP14A gene May be required for ribosome biogenesis. Indicus|evm.model.CM009511.1.494 Q9H7T0 CTSRB_HUMAN 71.892 0.934144 0.884409 CATSPERB - Cation channel sperm-associated protein subunit beta - Homo sapiens (Human) - CATSPERB gene Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Indicus|evm.model.CM009511.1.495 Q8N9U0 TAC2N_HUMAN 91.020 0.995927 1.00204 TC2N - Tandem C2 domains nuclear protein - Homo sapiens (Human) - TC2N gene nucleus Indicus|evm.model.CM009511.1.496 Q5EA62 FBLN5_BOVIN 99.330 0.995546 1.00223 FBLN5 - Fibulin-5 precursor - Bos taurus (Bovine) - FBLN5 gene Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Indicus|evm.model.CM009511.1.497 Q15643 TRIPB_HUMAN 84.741 0.98978 0.988883 TRIP11 - Thyroid receptor-interacting protein 11 - Homo sapiens (Human) - TRIP11 gene Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Indicus|evm.model.CM009511.1.498 Q3SZ63 NOP56_BOVIN 96.364 0.381786 0.958054 NOP56 - Nucleolar protein 56 - Bos taurus (Bovine) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Indicus|evm.model.CM009511.1.499 Q10568 CPSF2_BOVIN 100.000 0.997446 1.00128 CPSF2 - Cleavage and polyadenylation specificity factor subunit 2 - Bos taurus (Bovine) - CPSF2 gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing (By similarity). Indicus|evm.model.CM009511.1.501 Q8CGQ8 NCKX4_MOUSE 91.328 0.960924 0.905145 Slc24a4 - Sodium/potassium/calcium exchanger 4 precursor - Mus musculus (Mouse) - Slc24a4 gene Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis. Indicus|evm.model.CM009511.1.503 Q8TB24 RIN3_HUMAN 76.692 0.741573 0.361421 RIN3 - Ras and Rab interactor 3 - Homo sapiens (Human) - RIN3 gene Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. Indicus|evm.model.CM009511.1.504 Q8TB24 RIN3_HUMAN 74.455 0.996716 0.618274 RIN3 - Ras and Rab interactor 3 - Homo sapiens (Human) - RIN3 gene Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. Indicus|evm.model.CM009511.1.505 Q95M12 LGMN_BOVIN 99.307 0.995392 1.00231 LGMN - Legumain precursor - Bos taurus (Bovine) - LGMN gene Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Indicus|evm.model.CM009511.1.506 Q8TBA6 GOGA5_HUMAN 89.071 0.997271 1.00274 GOLGA5 - Golgin subfamily A member 5 - Homo sapiens (Human) - GOLGA5 gene Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. Indicus|evm.model.CM009511.1.507 P05059 CMGA_BOVIN 98.886 0.995556 1.00223 CHGA - Chromogranin-A precursor - Bos taurus (Bovine) - CHGA gene Strongly inhibits glucose induced insulin release from the pancreas. Indicus|evm.model.CM009511.1.508 P0C0T1 ITPK1_BOVIN 100.000 0.995238 1.00239 ITPK1 - Inositol-tetrakisphosphate 1-kinase - Bos taurus (Bovine) - ITPK1 gene Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity). Indicus|evm.model.CM009511.1.509 Q863G4 COX8A_CARSF 62.500 0.514286 1.01449 COX8A - Cytochrome c oxidase subunit 8A, mitochondrial precursor - Carlito syrichta (Philippine tarsier) - COX8A gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009511.1.510 P0C8B3 GON7_BOVIN 100.000 0.980198 1.01 GON7 - EKC/KEOPS complex subunit GON7 - Bos taurus (Bovine) - GON7 gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex. Indicus|evm.model.CM009511.1.511 Q8N806 UBR7_HUMAN 90.824 0.995305 1.00235 UBR7 - Putative E3 ubiquitin-protein ligase UBR7 - Homo sapiens (Human) - UBR7 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Indicus|evm.model.CM009511.1.512 Q9P203 BTBD7_HUMAN 95.671 0.998224 0.9947 BTBD7 - BTB/POZ domain-containing protein 7 - Homo sapiens (Human) - BTBD7 gene Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). Indicus|evm.model.CM009511.1.513 Q7Z4L0 COX8C_HUMAN 62.069 0.504425 1.56944 COX8C - Cytochrome c oxidase subunit 8C, mitochondrial precursor - Homo sapiens (Human) - COX8C gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009511.1.514 Q9P2D8 UNC79_HUMAN 92.738 0.997043 1.02657 UNC79 - Protein unc-79 homolog - Homo sapiens (Human) - UNC79 gene Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability. Indicus|evm.model.CM009511.1.515 Q86XR5 PRIMA_HUMAN 92.157 0.620408 1.60131 PRIMA1 - Proline-rich membrane anchor 1 precursor - Homo sapiens (Human) - PRIMA1 gene Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity). Indicus|evm.model.CM009511.1.516 Q8N9Y4 F181A_HUMAN 82.462 0.873315 1.04802 FAM181A - Protein FAM181A - Homo sapiens (Human) - FAM181A gene Indicus|evm.model.CM009511.1.517 Q3SX45 ASB2_BOVIN 99.842 0.996845 1.00158 ASB2 - Ankyrin repeat and SOCS box protein 2 - Bos taurus (Bovine) - ASB2 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009511.1.518 Q8NCU1 CC197_HUMAN 71.074 0.412371 2.03497 CCDC197 - Uncharacterized protein CCDC197 - Homo sapiens (Human) - CCDC197 gene Indicus|evm.model.CM009511.1.519 Q9CQX0 OTUB2_MOUSE 96.137 0.659091 1.50427 Otub2 - Ubiquitin thioesterase OTUB2 - Mus musculus (Mouse) - Otub2 gene Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains (By similarity). Indicus|evm.model.CM009511.1.520 Q9GZR7 DDX24_HUMAN 81.034 0.991841 0.998836 DDX24 - ATP-dependent RNA helicase DDX24 - Homo sapiens (Human) - DDX24 gene ATP-dependent RNA helicase. Indicus|evm.model.CM009511.1.521 Q8R412 IF27A_MOUSE 82.090 0.305556 2.4 Ifi27l2a - Interferon alpha-inducible protein 27-like protein 2A precursor - Mus musculus (Mouse) - Ifi27l2a gene May be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). Through the regulation of NR4A1 transcriptional activity, may play a role in the vascular response to injury (PubMed:22427340). Indicus|evm.model.CM009511.1.522 Q24JY7 I27L2_BOVIN 75.000 0.166197 2.66917 IFI27L2 - Interferon alpha-inducible protein 27-like protein 2 - Bos taurus (Bovine) - IFI27L2 gene Plays a role in the apoptotic process and has a pro-apoptotic activity. Indicus|evm.model.CM009511.1.523 Q24JY7 I27L2_BOVIN 100.000 0.985075 1.00752 IFI27L2 - Interferon alpha-inducible protein 27-like protein 2 - Bos taurus (Bovine) - IFI27L2 gene Plays a role in the apoptotic process and has a pro-apoptotic activity. Indicus|evm.model.CM009511.1.524 Q6NUP7 PP4R4_HUMAN 97.346 0.993056 0.824742 PPP4R4 - Serine/threonine-protein phosphatase 4 regulatory subunit 4 - Homo sapiens (Human) - PPP4R4 gene Putative regulatory subunit of serine/threonine-protein phosphatase 4. Indicus|evm.model.CM009511.1.525 Q9UK55 ZPI_HUMAN 66.444 0.966887 1.02027 SERPINA10 - Protein Z-dependent protease inhibitor precursor - Homo sapiens (Human) - SERPINA10 gene Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors. Indicus|evm.model.CM009511.1.526 E1BF81 CBG_BOVIN 99.752 0.995062 1.00248 SERPINA6 - Corticosteroid-binding globulin precursor - Bos taurus (Bovine) - SERPINA6 gene Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Indicus|evm.model.CM009511.1.527 P34955 A1AT_BOVIN 100.000 0.995204 1.0024 SERPINA1 - Alpha-1-antiproteinase precursor - Bos taurus (Bovine) - SERPINA1 gene Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity). Indicus|evm.model.CM009511.1.528 Q86U17 SPA11_HUMAN 79.384 0.995272 1.00237 SERPINA11 - Serpin A11 precursor - Homo sapiens (Human) - SERPINA11 gene extracellular space, serine-type endopeptidase inhibitor activity, negative regulation of endopeptidase activity Indicus|evm.model.CM009511.1.529 P46201 UTMP_BOVIN 96.514 0.995526 0.973856 Uterine milk protein precursor - Bos taurus (Bovine) Indicus|evm.model.CM009511.1.530 Q86WD7 SPA9_HUMAN 65.254 0.866667 0.323741 SERPINA9 - Serpin A9 precursor - Homo sapiens (Human) - SERPINA9 gene Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro). Indicus|evm.model.CM009511.1.531 Q8IW75 SPA12_HUMAN 66.425 0.995181 1.00242 SERPINA12 - Serpin A12 precursor - Homo sapiens (Human) - SERPINA12 gene Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. Indicus|evm.model.CM009511.1.533 Q5RCR2 KAIN_PONAB 58.824 0.990476 0.491803 SERPINA4 - Kallistatin precursor - Pongo abelii (Sumatran orangutan) - SERPINA4 gene Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Indicus|evm.model.CM009511.1.534 Q9N2I2 IPSP_BOVIN 100.000 0.995062 1.00248 SERPINA5 - Plasma serine protease inhibitor precursor - Bos taurus (Bovine) - SERPINA5 gene Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue- and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid (By similarity). Indicus|evm.model.CM009511.1.535 Q9TTE1 SPA31_BOVIN 100.000 0.85595 1.16545 SERPINA3-1 - Serpin A3-1 precursor - Bos taurus (Bovine) - SERPINA3-1 gene Potent inhibitor of the serine proteases elastase and trypsin. Moderately inhibits the serine proteases plasmin and chymotrypsin, and the thiol protease proenkephalin-processing enzyme. Does not inhibit the serine proteases cathepsin G, furin, kallikrein, thrombin, tissue plasminogen activator and urokinase, or the cysteine proteases cathepsin B, cathepsin L and papain. Indicus|evm.model.CM009511.1.536 Q9P1A6 DLGP2_HUMAN 76.417 0.726471 0.645161 DLGAP2 - Disks large-associated protein 2 - Homo sapiens (Human) - DLGAP2 gene May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Indicus|evm.model.CM009511.1.540 P97837 DLGP2_RAT 100.000 0.18239 0.150142 Dlgap2 - Disks large-associated protein 2 - Rattus norvegicus (Rat) - Dlgap2 gene May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Indicus|evm.model.CM009511.1.542 Q86X53 ERIC1_HUMAN 46.411 0.788969 0.941309 ERICH1 - Glutamate-rich protein 1 - Homo sapiens (Human) - ERICH1 gene Indicus|evm.model.CM009511.1.543 Q13136 LIPA1_HUMAN 74.766 0.301994 0.292013 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009511.1.544 Q3ZEJ6 SPA33_BOVIN 99.737 0.945137 0.975669 SERPINA3-3 - Serpin A3-3 precursor - Bos taurus (Bovine) - SERPINA3-3 gene Serine protease inhibitor. Strongly inhibits elastase and trypsin stoichiometrically at the molar ratio of 1:1. Acts as a moderate inhibitor of plasmin and chymotrypsin. Does not inhibit thrombin, urokinase, kallikrein, tissue plasminogen activator, cathepsin G or the cysteine proteases papain, cathepsin B or cathepsin L. Indicus|evm.model.CM009511.1.545 A2I7N3 SPA37_BOVIN 98.801 0.995215 1.0024 SERPINA3-7 - Serpin A3-7 precursor - Bos taurus (Bovine) - SERPINA3-7 gene Serine protease inhibitor. Indicus|evm.model.CM009511.1.546 A2I7N1 SPA35_BOVIN 95.631 0.995157 1.00487 SERPINA3-5 - Serpin A3-5 precursor - Bos taurus (Bovine) - SERPINA3-5 gene Serine protease inhibitor. Indicus|evm.model.CM009511.1.547 A6QPQ2 SPA38_BOVIN 99.761 0.995227 1.00239 SERPINA3-8 - Serpin A3-8 precursor - Bos taurus (Bovine) - SERPINA3-8 gene Serine protease inhibitor. Indicus|evm.model.CM009511.1.548 Q9TTE1 SPA31_BOVIN 69.257 0.871069 0.773723 SERPINA3-1 - Serpin A3-1 precursor - Bos taurus (Bovine) - SERPINA3-1 gene Potent inhibitor of the serine proteases elastase and trypsin. Moderately inhibits the serine proteases plasmin and chymotrypsin, and the thiol protease proenkephalin-processing enzyme. Does not inhibit the serine proteases cathepsin G, furin, kallikrein, thrombin, tissue plasminogen activator and urokinase, or the cysteine proteases cathepsin B, cathepsin L and papain. Indicus|evm.model.CM009511.1.549 A2T733 GSC_PANTR 94.094 0.752239 1.3035 GSC - Homeobox protein goosecoid - Pan troglodytes (Chimpanzee) - GSC gene Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity). Indicus|evm.model.CM009511.1.550 Q6TUI4 DICER_BOVIN 99.376 0.99896 1 DICER1 - Endoribonuclease Dicer - Bos taurus (Bovine) - DICER1 gene Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity). Indicus|evm.model.CM009511.1.551 Q96JQ2 CLMN_HUMAN 95.455 0.184599 0.946108 CLMN - Calmin - Homo sapiens (Human) - CLMN gene cytoplasm, meiotic nuclear membrane microtubule tethering complex, nuclear outer membrane, actin filament binding, negative regulation of cell population proliferation, nuclear migration Indicus|evm.model.CM009511.1.552 A2I7N3 SPA37_BOVIN 91.367 0.995215 1.0024 SERPINA3-7 - Serpin A3-7 precursor - Bos taurus (Bovine) - SERPINA3-7 gene Serine protease inhibitor. Indicus|evm.model.CM009511.1.553 Q9TTE1 SPA31_BOVIN 92.784 0.631579 0.36983 SERPINA3-1 - Serpin A3-1 precursor - Bos taurus (Bovine) - SERPINA3-1 gene Potent inhibitor of the serine proteases elastase and trypsin. Moderately inhibits the serine proteases plasmin and chymotrypsin, and the thiol protease proenkephalin-processing enzyme. Does not inhibit the serine proteases cathepsin G, furin, kallikrein, thrombin, tissue plasminogen activator and urokinase, or the cysteine proteases cathepsin B, cathepsin L and papain. Indicus|evm.model.CM009511.1.554 Q6ZMZ3 SYNE3_HUMAN 77.459 0.997925 0.988718 SYNE3 - Nesprin-3 - Homo sapiens (Human) - SYNE3 gene As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. Indicus|evm.model.CM009511.1.555 Q80Y14 GLRX5_MOUSE 94.068 0.735849 1.04605 Glrx5 - Glutaredoxin-related protein 5, mitochondrial precursor - Mus musculus (Mouse) - Glrx5 gene Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:19442627). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (By similarity). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (By similarity). Indicus|evm.model.CM009511.1.556 O95988 TCL1B_HUMAN 48.387 0.952756 0.992188 TCL1B - T-cell leukemia/lymphoma protein 1B - Homo sapiens (Human) - TCL1B gene Enhances the phosphorylation and activation of AKT1 and AKT2. Indicus|evm.model.CM009511.1.557 P56279 TCL1A_HUMAN 61.062 0.948276 1.01754 TCL1A - T-cell leukemia/lymphoma protein 1A - Homo sapiens (Human) - TCL1A gene Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Indicus|evm.model.CM009511.1.558 Q9NPU4 CN132_HUMAN 96.386 0.40796 2.42169 C14orf132 - Uncharacterized protein C14orf132 - Homo sapiens (Human) - C14orf132 gene Indicus|evm.model.CM009511.1.559 Q9GLX8 BKRB2_PIG 86.704 0.944882 1.03815 BDKRB2 - B2 bradykinin receptor - Sus scrofa (Pig) - BDKRB2 gene Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Indicus|evm.model.CM009511.1.560 Q8HZP2 BKRB1_MACMU 77.841 0.994334 1.00284 BDKRB1 - B1 bradykinin receptor - Macaca mulatta (Rhesus macaque) - BDKRB1 gene This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation (By similarity). Indicus|evm.model.CM009511.1.561 Q96BY7 ATG2B_HUMAN 93.455 0.999038 1.00048 ATG2B - Autophagy-related protein 2 homolog B - Homo sapiens (Human) - ATG2B gene Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:31721365). Indicus|evm.model.CM009511.1.562 Q0P5A3 GSKIP_BOVIN 100.000 0.985714 1.00719 GSKIP - GSK3B-interacting protein - Bos taurus (Bovine) - GSKIP gene A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity). Indicus|evm.model.CM009511.1.563 Q9D2H2 KAD7_MOUSE 88.130 0.846897 1.18078 Ak7 - Adenylate kinase 7 - Mus musculus (Mouse) - Ak7 gene Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function. Indicus|evm.model.CM009511.1.564 P25500 PAPOA_BOVIN 100.000 0.997297 1.00135 PAPOLA - Poly(A) polymerase alpha - Bos taurus (Bovine) - PAPOLA gene Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. Indicus|evm.model.CM009511.1.566 Q9NR30 DDX21_HUMAN 75.410 0.962162 0.236271 DDX21 - Nucleolar RNA helicase 2 - Homo sapiens (Human) - DDX21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Indicus|evm.model.CM009511.1.567 Q32PI1 VRK1_BOVIN 91.667 0.922535 1.07576 VRK1 - Serine/threonine-protein kinase VRK1 - Bos taurus (Bovine) - VRK1 gene Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity (By similarity). Indicus|evm.model.CM009511.1.571 Q9C0K0 BC11B_HUMAN 97.708 0.707317 0.550336 BCL11B - B-cell lymphoma/leukemia 11B - Homo sapiens (Human) - BCL11B gene Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). Indicus|evm.model.CM009511.1.572 Q9C0K0 BC11B_HUMAN 93.007 0.561265 0.282998 BCL11B - B-cell lymphoma/leukemia 11B - Homo sapiens (Human) - BCL11B gene Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). Indicus|evm.model.CM009511.1.575 B2KI88 SETD3_RHIFE 93.255 0.981728 1.01347 SETD3 - Actin-histidine N-methyltransferase - Rhinolophus ferrumequinum (Greater horseshoe bat) - SETD3 gene Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin. Indicus|evm.model.CM009511.1.576 O88874 CCNK_MOUSE 93.792 0.955319 0.848375 Ccnk - Cyclin-K - Mus musculus (Mouse) - Ccnk gene Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). Indicus|evm.model.CM009511.1.577 A6NKD9 CC85C_HUMAN 93.548 0.709677 0.5179 CCDC85C - Coiled-coil domain-containing protein 85C - Homo sapiens (Human) - CCDC85C gene May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). Indicus|evm.model.CM009511.1.578 A6NKD9 CC85C_HUMAN 97.727 0.308511 0.673031 CCDC85C - Coiled-coil domain-containing protein 85C - Homo sapiens (Human) - CCDC85C gene May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). Indicus|evm.model.CM009511.1.579 Q14DK5 HIPL1_MOUSE 79.261 0.903394 0.968394 Hhipl1 - HHIP-like protein 1 precursor - Mus musculus (Mouse) - Hhipl1 gene Indicus|evm.model.CM009511.1.580 Q9Y6A2 CP46A_HUMAN 80.000 0.933333 0.99 CYP46A1 - Cholesterol 24-hydroxylase - Homo sapiens (Human) - CYP46A1 gene P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697, PubMed:25017465, PubMed:18621681). By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning (By similarity). Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis (PubMed:12077124, PubMed:14640697, PubMed:28190002). Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain (PubMed:25017465). May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole (PubMed:20667828). Indicus|evm.model.CM009511.1.581 O00423 EMAL1_HUMAN 92.160 0.995215 0.769325 EML1 - Echinoderm microtubule-associated protein-like 1 - Homo sapiens (Human) - EML1 gene Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. Indicus|evm.model.CM009511.1.582 O00423 EMAL1_HUMAN 98.969 0.518919 0.226994 EML1 - Echinoderm microtubule-associated protein-like 1 - Homo sapiens (Human) - EML1 gene Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. Indicus|evm.model.CM009511.1.583 Q5R896 EVL_PONAB 94.458 0.985714 0.995261 EVL - Ena/VASP-like protein - Pongo abelii (Sumatran orangutan) - EVL gene Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization (By similarity). Indicus|evm.model.CM009511.1.584 Q0II71 DEGS2_BOVIN 97.059 0.64346 1.46749 DEGS2 - Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 - Bos taurus (Bovine) - DEGS2 gene Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. Indicus|evm.model.CM009511.1.585 Q28029 VATF_BOVIN 100.000 0.964912 0.957983 ATP6V1F - V-type proton ATPase subunit F - Bos taurus (Bovine) - ATP6V1F gene Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Indicus|evm.model.CM009511.1.586 P25490 TYY1_HUMAN 97.904 0.993994 0.804348 YY1 - Transcriptional repressor protein YY1 - Homo sapiens (Human) - YY1 gene Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Indicus|evm.model.CM009511.1.587 Q08DK7 MCATL_BOVIN 100.000 0.848571 1.1745 SLC25A29 - Mitochondrial basic amino acids transporter - Bos taurus (Bovine) - SLC25A29 gene Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms. Indicus|evm.model.CM009511.1.588 Q6Q0C1 S2547_HUMAN 86.901 0.99361 1.01623 SLC25A47 - Solute carrier family 25 member 47 - Homo sapiens (Human) - SLC25A47 gene Uncoupling protein which may catalyze the physiological 'proton leak' in liver. Overexpression induces the dissipation of mitochondrial membrane potential. Indicus|evm.model.CM009511.1.589 P17248 SYWC_BOVIN 99.370 0.995807 1.0021 WARS1 - Tryptophan--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - WARS1 gene T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). Indicus|evm.model.CM009511.1.590 Q64LD2 WDR25_HUMAN 76.252 0.996296 0.992647 WDR25 - WD repeat-containing protein 25 - Homo sapiens (Human) - WDR25 gene Indicus|evm.model.CM009511.1.591 Q6R6L0 BEGIN_SHEEP 97.950 0.996845 0.970904 BEGAIN - Brain-enriched guanylate kinase-associated protein - Ovis aries (Sheep) - BEGAIN gene May sustain the structure of the postsynaptic density (PSD). Indicus|evm.model.CM009511.1.595 P80370 DLK1_HUMAN 83.029 0.994792 1.00261 DLK1 - Protein delta homolog 1 precursor - Homo sapiens (Human) - DLK1 gene May have a role in neuroendocrine differentiation. Indicus|evm.model.CM009511.1.598 Q52QI2 RTL1_BOVIN 99.925 0.998498 1.00075 RTL1 - Retrotransposon-like protein 1 - Bos taurus (Bovine) - RTL1 gene Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta. Indicus|evm.model.CM009511.1.602 Q5I3B1 IOD3_BOVIN 91.007 0.992126 0.843854 DIO3 - Thyroxine 5-deiodinase - Bos taurus (Bovine) - DIO3 gene Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. Indicus|evm.model.CM009511.1.603 Q13362 2A5G_HUMAN 94.902 0.889474 1.08779 PPP2R5C - Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform - Homo sapiens (Human) - PPP2R5C gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. Indicus|evm.model.CM009511.1.605 Q14204 DYHC1_HUMAN 99.031 0.99957 1 DYNC1H1 - Cytoplasmic dynein 1 heavy chain 1 - Homo sapiens (Human) - DYNC1H1 gene Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). Indicus|evm.model.CM009511.1.608 Q76LV2 HS90A_BOVIN 100.000 0.997275 1.00136 HSP90AA1 - Heat shock protein HSP 90-alpha - Bos taurus (Bovine) - HSP90AA1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response. Indicus|evm.model.CM009511.1.609 Q8TBZ3 WDR20_HUMAN 97.012 0.996491 1.00176 WDR20 - WD repeat-containing protein 20 - Homo sapiens (Human) - WDR20 gene Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Indicus|evm.model.CM009511.1.610 Q9WVS4 MOK_MOUSE 81.235 0.990453 0.997619 Mok - MAPK/MAK/MRK overlapping kinase - Mus musculus (Mouse) - Mok gene Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (PubMed:10421840). Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner (PubMed:25243405). Indicus|evm.model.CM009511.1.612 A8K0R7 ZN839_HUMAN 59.785 0.802752 0.806412 ZNF839 - Zinc finger protein 839 - Homo sapiens (Human) - ZNF839 gene Indicus|evm.model.CM009511.1.613 A6H7E2 CINP_BOVIN 100.000 0.696667 1.41509 CINP - Cyclin-dependent kinase 2-interacting protein - Bos taurus (Bovine) - CINP gene Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling (By similarity). Indicus|evm.model.CM009511.1.614 O15040 TCPR2_HUMAN 78.407 0.901057 0.938342 TECPR2 - Tectonin beta-propeller repeat-containing protein 2 - Homo sapiens (Human) - TECPR2 gene Probably plays a role as positive regulator of autophagy. Indicus|evm.model.CM009511.1.615 O15040 TCPR2_HUMAN 80.702 0.694561 0.169383 TECPR2 - Tectonin beta-propeller repeat-containing protein 2 - Homo sapiens (Human) - TECPR2 gene Probably plays a role as positive regulator of autophagy. Indicus|evm.model.CM009511.1.616 Q96BM1 ANKR9_HUMAN 91.667 0.821782 0.318612 ANKRD9 - Ankyrin repeat domain-containing protein 9 - Homo sapiens (Human) - ANKRD9 gene Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:30293565). Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly (PubMed:30293565, PubMed:31337707). Implicated in different cellular processes, like copper homeostasis and cell proliferation (PubMed:24522796, PubMed:30293565). Indicus|evm.model.CM009511.1.617 Q9UKL0 RCOR1_HUMAN 96.448 0.983784 0.762887 RCOR1 - REST corepressor 1 - Homo sapiens (Human) - RCOR1 gene Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Indicus|evm.model.CM009511.1.619 O46415 FRIL_BOVIN 95.429 0.988636 1.00571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009511.1.620 Q60803 TRAF3_MOUSE 95.599 0.974227 1.02646 Traf3 - TNF receptor-associated factor 3 - Mus musculus (Mouse) - Traf3 gene Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. Indicus|evm.model.CM009511.1.621 F1SAM7 AMNLS_PIG 84.058 0.176166 0.743738 AMN - Protein amnionless precursor - Sus scrofa (Pig) - AMN gene Membrane-bound component of the endocytic receptor formed by AMN and CUBN (PubMed:30523278). Required for normal CUBN glycosylation and trafficking to the cell surface. The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12. Required for normal CUBN-mediated protein transport in the kidney (By similarity). Indicus|evm.model.CM009511.1.622 Q9Y5S2 MRCKB_HUMAN 90.882 0.968403 0.998831 CDC42BPB - Serine/threonine-protein kinase MRCK beta - Homo sapiens (Human) - CDC42BPB gene Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Indicus|evm.model.CM009511.1.624 Q5ZM46 LBH_CHICK 78.571 0.27 0.943396 LBH - Protein LBH - Gallus gallus (Chicken) - LBH gene Transcriptional activator. Indicus|evm.model.CM009511.1.625 Q17RC7 EX3L4_HUMAN 70.274 0.997245 1.00554 EXOC3L4 - Exocyst complex component 3-like protein 4 - Homo sapiens (Human) - EXOC3L4 gene exocyst, SNARE binding, exocyst localization, exocytosis Indicus|evm.model.CM009511.1.626 Q6DIA2 EX3L4_MOUSE 53.435 0.882576 0.366158 Exoc3l4 - Exocyst complex component 3-like protein 4 - Mus musculus (Mouse) - Exoc3l4 gene exocyst, SNARE binding, exocyst localization, exocytosis Indicus|evm.model.CM009511.1.627 Q03169 TNAP2_HUMAN 79.545 0.325409 1.02905 TNFAIP2 - Tumor necrosis factor alpha-induced protein 2 - Homo sapiens (Human) - TNFAIP2 gene May play a role as a mediator of inflammation and angiogenesis. Indicus|evm.model.CM009511.1.629 Q8BU31 RAP2C_MOUSE 45.390 0.147679 5.18033 Rap2c - Ras-related protein Rap-2c precursor - Mus musculus (Mouse) - Rap2c gene Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. Indicus|evm.model.CM009511.1.630 Q5R4L0 IF5_PONAB 97.680 0.995349 0.99768 EIF5 - Eukaryotic translation initiation factor 5 - Pongo abelii (Sumatran orangutan) - EIF5 gene Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity). Indicus|evm.model.CM009511.1.631 P27448 MARK3_HUMAN 97.372 0.996914 0.860558 MARK3 - MAP/microtubule affinity-regulating kinase 3 - Homo sapiens (Human) - MARK3 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Indicus|evm.model.CM009511.1.632 Q5EA61 KCRB_BOVIN 100.000 0.994764 1.00262 CKB - Creatine kinase B-type - Bos taurus (Bovine) - CKB gene Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). Indicus|evm.model.CM009511.1.633 A6H791 TRM61_BOVIN 100.000 0.993007 1.00351 TRMT61A - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A - Bos taurus (Bovine) - TRMT61A gene Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. Indicus|evm.model.CM009511.1.634 Q2TA08 BAG5_BOVIN 100.000 0.995536 1.00224 BAG5 - BAG family molecular chaperone regulator 5 - Bos taurus (Bovine) - BAG5 gene May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). Indicus|evm.model.CM009511.1.635 Q148E1 COA8_BOVIN 100.000 0.989637 1.00521 COA8 - Cytochrome c oxidase assembly factor 8 precursor - Bos taurus (Bovine) - COA8 gene Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain. Indicus|evm.model.CM009511.1.636 Q5R581 KLC1_PONAB 98.909 0.840735 1.16607 KLC1 - Kinesin light chain 1 - Pongo abelii (Sumatran orangutan) - KLC1 gene Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). Indicus|evm.model.CM009511.1.638 Q08DH8 XRCC3_BOVIN 99.465 0.704545 0.774194 XRCC3 - DNA repair protein XRCC3 - Bos taurus (Bovine) - XRCC3 gene Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C (By similarity). Indicus|evm.model.CM009511.1.639 Q05B78 ZFY21_BOVIN 100.000 0.990244 0.807087 ZFYVE21 - Zinc finger FYVE domain-containing protein 21 - Bos taurus (Bovine) - ZFYVE21 gene Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression (By similarity). Indicus|evm.model.CM009511.1.640 Q96KQ4 ASPP1_HUMAN 90.064 0.998152 0.992661 PPP1R13B - Apoptosis-stimulating of p53 protein 1 - Homo sapiens (Human) - PPP1R13B gene Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Indicus|evm.model.CM009511.1.642 P14790 ATP68_BOVIN 96.226 0.353741 2.45 ATP5MJ - ATP synthase subunit ATP5MJ, mitochondrial - Bos taurus (Bovine) - ATP5MJ gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Minor subunit required to maintain the ATP synthase population in the mitochondria. Indicus|evm.model.CM009511.1.643 Q8NDG6 TDRD9_HUMAN 82.507 0.998585 1.02243 TDRD9 - ATP-dependent RNA helicase TDRD9 - Homo sapiens (Human) - TDRD9 gene ATP-binding RNA helicase required during spermatogenesis (PubMed:28536242). Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4. Indicus|evm.model.CM009511.1.644 Q86U10 LPP60_HUMAN 80.977 0.996503 0.998255 ASPG - 60 kDa lysophospholipase - Homo sapiens (Human) - ASPG gene Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity). Indicus|evm.model.CM009511.1.645 Q9ULI4 KI26A_HUMAN 74.815 0.478689 0.97237 KIF26A - Kinesin-like protein KIF26A - Homo sapiens (Human) - KIF26A gene Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Indicus|evm.model.CM009511.1.649 Q29RM6 NRAC_BOVIN 96.855 0.9875 1.00629 NRAC - Nutritionally-regulated adipose and cardiac-enriched protein homolog - Bos taurus (Bovine) - NRAC gene plasma membrane Indicus|evm.model.CM009511.1.650 Q6ZVK1 T179A_HUMAN 94.850 0.991416 1 TMEM179 - Transmembrane protein 179 - Homo sapiens (Human) - TMEM179 gene Indicus|evm.model.CM009511.1.653 Q0GNC1 INF2_MOUSE 85.678 0.381232 0.803614 Inf2 - Inverted formin-2 - Mus musculus (Mouse) - Inf2 gene Severs actin filaments and accelerates their polymerization and depolymerization. Indicus|evm.model.CM009511.1.654 A5PJR4 PURA1_BOVIN 99.562 0.995633 1.00219 ADSS1 - Adenylosuccinate synthetase isozyme 1 - Bos taurus (Bovine) - ADSS1 gene Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Indicus|evm.model.CM009511.1.655 O15304 SIVA_HUMAN 76.571 0.983051 1.01143 SIVA1 - Apoptosis regulatory protein Siva - Homo sapiens (Human) - SIVA1 gene Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. Indicus|evm.model.CM009511.1.656 Q01314 AKT1_BOVIN 88.958 0.826923 1.08333 AKT1 - RAC-alpha serine/threonine-protein kinase - Bos taurus (Bovine) - AKT1 gene AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (By similarity). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (By similarity). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (By similarity). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) (By similarity). AKT mediates the antiapoptotic effects of IGF-I (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (By similarity). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53. Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility. Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation. Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (By similarity). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (By similarity). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (By similarity). Indicus|evm.model.CM009511.1.657 Q7ZWZ4 ZB182_XENLA 92.593 0.232558 0.728814 zbtb18.2 - Zinc finger and BTB domain-containing protein 18.2 - Xenopus laevis (African clawed frog) - zbtb18.2 gene Transcriptional repressor that plays a role in various developmental processes. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes (By similarity). Indicus|evm.model.CM009511.1.658 Q80U49 C170B_MOUSE 90.244 0.243902 0.104193 Cep170b - Centrosomal protein of 170 kDa protein B - Mus musculus (Mouse) - Cep170b gene Plays a role in microtubule organization. Indicus|evm.model.CM009511.1.659 Q9Y4F5 C170B_HUMAN 74.104 0.988889 1.01951 CEP170B - Centrosomal protein of 170 kDa protein B - Homo sapiens (Human) - CEP170B gene Plays a role in microtubule organization. Indicus|evm.model.CM009511.1.660 Q96BZ4 PLD4_HUMAN 72.141 0.878788 0.978261 PLD4 - 5'-3' exonuclease PLD4 - Homo sapiens (Human) - PLD4 gene 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia. Indicus|evm.model.CM009511.1.661 Q8IVF2 AHNK2_HUMAN 55.263 0.105539 0.295945 AHNAK2 - Protein AHNAK2 - Homo sapiens (Human) - AHNAK2 gene costamere, cytoplasm, cytoplasmic vesicle membrane, cytosol, nucleus, plasma membrane, sarcolemma, T-tubule, Z disc, regulation of RNA splicing Indicus|evm.model.CM009511.1.662 Q17QP7 CLBA1_BOVIN 96.581 0.983051 0.35119 CLBA1 - Uncharacterized protein CLBA1 - Bos taurus (Bovine) - CLBA1 gene AP-1 adaptor complex, trans-Golgi network membrane, clathrin binding, intracellular transport Indicus|evm.model.CM009511.1.664 Q9BXL8 CDCA4_HUMAN 61.570 0.991031 0.925311 CDCA4 - Cell division cycle-associated protein 4 - Homo sapiens (Human) - CDCA4 gene May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity). Indicus|evm.model.CM009511.1.665 Q9UNW8 GP132_HUMAN 66.576 0.581876 1.65526 GPR132 - Probable G-protein coupled receptor 132 - Homo sapiens (Human) - GPR132 gene May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity. Indicus|evm.model.CM009511.1.668 Q9Y219 JAG2_HUMAN 89.835 0.90893 0.91357 JAG2 - Protein jagged-2 precursor - Homo sapiens (Human) - JAG2 gene Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). Indicus|evm.model.CM009511.1.669 Q05B60 NUD14_BOVIN 100.000 0.894495 0.981982 NUDT14 - Uridine diphosphate glucose pyrophosphatase NUDT14 - Bos taurus (Bovine) - NUDT14 gene Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose (By similarity). Indicus|evm.model.CM009511.1.670 Q92994 TF3B_HUMAN 80.908 0.84543 1.09897 BRF1 - Transcription factor IIIB 90 kDa subunit - Homo sapiens (Human) - BRF1 gene General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. Indicus|evm.model.CM009511.1.671 Q86VP3 PACS2_HUMAN 84.579 0.955241 0.955006 PACS2 - Phosphofurin acidic cluster sorting protein 2 - Homo sapiens (Human) - PACS2 gene Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. Indicus|evm.model.CM009511.1.672 C9J3V5 TEX22_HUMAN 57.647 0.982558 1.14667 TEX22 - Testis-expressed protein 22 - Homo sapiens (Human) - TEX22 gene Indicus|evm.model.CM009511.1.673 Q62599 MTA1_RAT 76.791 0.729761 1.24751 Mta1 - Metastasis-associated protein MTA1 - Rattus norvegicus (Rat) - Mta1 gene Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). Isoform 2 may be involved in the sorting of amylase during zymogen granule formation in the pancreas. With Tfcp2l1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). Indicus|evm.model.CM009511.1.674 Q86SX3 TEDC1_HUMAN 76.316 0.548872 0.268687 TEDC1 - Tubulin epsilon and delta complex protein 1 - Homo sapiens (Human) - TEDC1 gene Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability (By similarity). May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F (PubMed:28796488). Indicus|evm.model.CM009511.1.675 Q8WMY2 FPPS_BOVIN 75.831 0.436137 1.8187 FDPS - Farnesyl pyrophosphate synthase - Bos taurus (Bovine) - FDPS gene Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). Indicus|evm.model.CM009511.1.676 Q80XA0 TM121_MOUSE 99.259 0.755618 1.1195 Tmem121 - Transmembrane protein 121 - Mus musculus (Mouse) - Tmem121 gene May play a role in MAPK signaling. Indicus|evm.model.CM009511.1.677 P01877 IGHA2_HUMAN 64.400 0.283257 2.56471 IGHA2 - Immunoglobulin heavy constant alpha 2 - Homo sapiens (Human) - IGHA2 gene Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915). Indicus|evm.model.CM009511.1.679 P01820 HVM44_MOUSE 69.091 0.670807 1.4 Ig heavy chain V region PJ14 precursor - Mus musculus (Mouse) Indicus|evm.model.CM009511.1.680 P0DP08 HVD82_HUMAN 65.812 0.537383 1.82906 IGHV4-38-2 - Immunoglobulin heavy variable 4-38-2 precursor - Homo sapiens (Human) - IGHV4-38-2 gene V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Indicus|evm.model.CM009511.1.681 Q9JI76 ADA21_MOUSE 47.581 0.535398 0.310014 Adam21 - Disintegrin and metalloproteinase domain-containing protein 21 precursor - Mus musculus (Mouse) - Adam21 gene May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. Indicus|evm.model.CM009511.1.682 P01820 HVM44_MOUSE 66.055 0.877049 1.06087 Ig heavy chain V region PJ14 precursor - Mus musculus (Mouse) Indicus|evm.model.CM009512.1.1 Q13136 LIPA1_HUMAN 59.155 0.507194 0.231281 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009512.1.2 Q9UPS8 ANR26_HUMAN 71.351 0.549254 0.195906 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009512.1.3 Q6RFH8 DUX4C_HUMAN 64.286 0.146667 1.00267 DUX4L9 - Double homeobox protein 4C - Homo sapiens (Human) - DUX4L9 gene May be involved in transcriptional regulation (By similarity). Down-regulates MYOD1 expression and may up-regulate MYF5 expression. May regulate microRNA (miRNA) transcription, upregulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206. Impairs the differentiation of myoblasts and may be involved in muscle regeneration. Indicus|evm.model.CM009512.1.6 Q2M2T7 RT24_BOVIN 99.401 0.988095 1.00599 MRPS24 - 28S ribosomal protein S24, mitochondrial precursor - Bos taurus (Bovine) - MRPS24 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009512.1.7 A0JN92 URGCP_BOVIN 100.000 0.997833 1.00108 URGCP - Up-regulator of cell proliferation - Bos taurus (Bovine) - URGCP gene May be involved in cell cycle progression through the regulation of cyclin D1 expression. Indicus|evm.model.CM009512.1.8 Q9Y2X8 UB2D4_HUMAN 99.320 0.935897 1.06122 UBE2D4 - Ubiquitin-conjugating enzyme E2 D4 - Homo sapiens (Human) - UBE2D4 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination. Indicus|evm.model.CM009512.1.9 A6H7G2 DBNL_BOVIN 100.000 0.995283 1.00236 DBNL - Drebrin-like protein - Bos taurus (Bovine) - DBNL gene Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes (By similarity). Indicus|evm.model.CM009512.1.10 Q32KV0 PGAM2_BOVIN 99.209 0.992126 1.00395 PGAM2 - Phosphoglycerate mutase 2 - Bos taurus (Bovine) - PGAM2 gene Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. Indicus|evm.model.CM009512.1.11 A6QNZ8 VOPP1_BOVIN 100.000 0.875 0.883721 VOPP1 - Vesicular, overexpressed in cancer, prosurvival protein 1 precursor - Bos taurus (Bovine) - VOPP1 gene Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. Indicus|evm.model.CM009512.1.13 Q9NS86 LANC2_HUMAN 87.556 0.982301 1.00444 LANCL2 - LanC-like protein 2 - Homo sapiens (Human) - LANCL2 gene Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Indicus|evm.model.CM009512.1.16 P24049 RL17_RAT 90.761 0.989189 1.00543 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009512.1.17 P60060 SC61G_MOUSE 100.000 0.62037 1.58824 Sec61g - Protein transport protein Sec61 subunit gamma - Mus musculus (Mouse) - Sec61g gene Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (By similarity). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). Indicus|evm.model.CM009512.1.18 Q6ZWH5 NEK10_HUMAN 90.367 0.998282 0.993174 NEK10 - Serine/threonine-protein kinase Nek10 - Homo sapiens (Human) - NEK10 gene Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport (PubMed:31959991). Indicus|evm.model.CM009512.1.19 Q9Y6M7 S4A7_HUMAN 99.167 0.212823 0.925041 SLC4A7 - Sodium bicarbonate cotransporter 3 - Homo sapiens (Human) - SLC4A7 gene Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. Indicus|evm.model.CM009512.1.21 O95936 EOMES_HUMAN 92.340 0.997151 1.02332 EOMES - Eomesodermin homolog - Homo sapiens (Human) - EOMES gene Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. Indicus|evm.model.CM009512.1.22 Q3SZM6 COXM1_BOVIN 100.000 0.981308 1.00943 CMC1 - COX assembly mitochondrial protein homolog - Bos taurus (Bovine) - CMC1 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Indicus|evm.model.CM009512.1.23 Q3SYW5 AZI2_BOVIN 100.000 0.994924 1.00254 AZI2 - 5-azacytidine-induced protein 2 - Bos taurus (Bovine) - AZI2 gene Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity). Indicus|evm.model.CM009512.1.25 Q504Y3 ZCPW2_HUMAN 85.135 0.885542 0.466292 ZCWPW2 - Zinc finger CW-type PWWP domain protein 2 - Homo sapiens (Human) - ZCWPW2 gene Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). Indicus|evm.model.CM009512.1.26 Q504Y3 ZCPW2_HUMAN 60.000 0.765957 0.52809 ZCWPW2 - Zinc finger CW-type PWWP domain protein 2 - Homo sapiens (Human) - ZCWPW2 gene Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). Indicus|evm.model.CM009512.1.29 Q6XE24 RBMS3_HUMAN 99.361 0.996805 0.716247 RBMS3 - RNA-binding motif, single-stranded-interacting protein 3 - Homo sapiens (Human) - RBMS3 gene Binds poly(A) and poly(U) oligoribonucleotides. Indicus|evm.model.CM009512.1.30 P38438 TGFR2_RAT 93.548 0.0560748 0.943563 Tgfbr2 - TGF-beta receptor type-2 precursor - Rattus norvegicus (Rat) - Tgfbr2 gene Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity). Indicus|evm.model.CM009512.1.31 A6QM00 GADL1_BOVIN 89.544 0.995816 0.917466 GADL1 - Acidic amino acid decarboxylase GADL1 - Bos taurus (Bovine) - GADL1 gene Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is L-aspartate. Does not exhibit any decarboxylation activity toward glutamate. Indicus|evm.model.CM009512.1.32 A2SW69 ANXA2_SHEEP 82.822 0.987805 0.483776 ANXA2 - Annexin A2 - Ovis aries (Sheep) - ANXA2 gene Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Indicus|evm.model.CM009512.1.33 A2SW69 ANXA2_SHEEP 85.484 0.616162 0.292035 ANXA2 - Annexin A2 - Ovis aries (Sheep) - ANXA2 gene Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Indicus|evm.model.CM009512.1.35 E2RG47 STT3B_CANLF 98.789 0.99757 0.996368 STT3B - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B - Canis lupus familiaris (Dog) - STT3B gene Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation (PubMed:12887896). Indicus|evm.model.CM009512.1.36 Q9BXB5 OSB10_HUMAN 92.481 0.92757 0.560209 OSBPL10 - Oxysterol-binding protein-related protein 10 - Homo sapiens (Human) - OSBPL10 gene Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). Indicus|evm.model.CM009512.1.37 Q9BXB5 OSB10_HUMAN 91.358 0.995885 0.318063 OSBPL10 - Oxysterol-binding protein-related protein 10 - Homo sapiens (Human) - OSBPL10 gene Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). Indicus|evm.model.CM009512.1.38 Q8N335 GPD1L_HUMAN 97.305 0.930168 1.01994 GPD1L - Glycerol-3-phosphate dehydrogenase 1-like protein - Homo sapiens (Human) - GPD1L gene Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. Indicus|evm.model.CM009512.1.39 Q1RMP9 CKLF8_BOVIN 100.000 0.597087 1.19075 CMTM8 - CKLF-like MARVEL transmembrane domain-containing protein 8 - Bos taurus (Bovine) - CMTM8 gene integral component of membrane, structural constituent of myelin sheath, myelination Indicus|evm.model.CM009512.1.40 Q96FZ5 CKLF7_HUMAN 83.908 0.988571 1 CMTM7 - CKLF-like MARVEL transmembrane domain-containing protein 7 - Homo sapiens (Human) - CMTM7 gene integral component of membrane, membrane Indicus|evm.model.CM009512.1.41 Q5RFC1 CKLF6_PONAB 71.585 0.989071 1 CMTM6 - CKLF-like MARVEL transmembrane domain-containing protein 6 - Pongo abelii (Sumatran orangutan) - CMTM6 gene Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. Indicus|evm.model.CM009512.1.42 Q9Y6G9 DC1L1_HUMAN 95.038 0.996183 1.00191 DYNC1LI1 - Cytoplasmic dynein 1 light intermediate chain 1 - Homo sapiens (Human) - DYNC1LI1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Indicus|evm.model.CM009512.1.43 A4IFB6 CNO10_BOVIN 100.000 0.997312 1.00135 CNOT10 - CCR4-NOT transcription complex subunit 10 - Bos taurus (Bovine) - CNOT10 gene CCR4-NOT complex, mRNA catabolic process, negative regulation of translation Indicus|evm.model.CM009512.1.45 E1BJS7 LIN41_BOVIN 100.000 0.971667 0.691244 TRIM71 - E3 ubiquitin-protein ligase TRIM71 - Bos taurus (Bovine) - TRIM71 gene E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (By similarity). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (By similarity). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity). Indicus|evm.model.CM009512.1.47 Q8MJW8 CCR4_CANLF 91.389 0.994444 1 CCR4 - C-C chemokine receptor type 4 - Canis lupus familiaris (Dog) - CCR4 gene High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival (By similarity). Indicus|evm.model.CM009512.1.48 Q58D55 BGAL_BOVIN 99.387 0.996942 1.00153 GLB1 - Beta-galactosidase precursor - Bos taurus (Bovine) - GLB1 gene Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Indicus|evm.model.CM009512.1.49 Q3ZBM5 SNX5_BOVIN 98.049 0.832653 0.606436 SNX5 - Sorting nexin-5 - Bos taurus (Bovine) - SNX5 gene Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin. Plays a role in the internalization of EGFR after EGF stimulation. Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C and is retromer-independent. Together with PIP5K1C facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation. Plays a role in macropinocytosis (By similarity). Indicus|evm.model.CM009512.1.50 O75718 CRTAP_HUMAN 95.262 0.995025 1.00249 CRTAP - Cartilage-associated protein precursor - Homo sapiens (Human) - CRTAP gene Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. Indicus|evm.model.CM009512.1.51 O60279 SUSD5_HUMAN 74.961 0.9968 0.993641 SUSD5 - Sushi domain-containing protein 5 precursor - Homo sapiens (Human) - SUSD5 gene Notch signaling pathway Indicus|evm.model.CM009512.1.52 A6H779 FBXL2_BOVIN 100.000 0.995283 1.00236 FBXL2 - F-box/LRR-repeat protein 2 - Bos taurus (Bovine) - FBXL2 gene Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy. PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant. Indicus|evm.model.CM009512.1.53 Q9NZI7 UBIP1_HUMAN 92.963 0.996276 0.994444 UBP1 - Upstream-binding protein 1 - Homo sapiens (Human) - UBP1 gene Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. Indicus|evm.model.CM009512.1.54 O75122 CLAP2_HUMAN 96.354 0.840924 1.17079 CLASP2 - CLIP-associating protein 2 - Homo sapiens (Human) - CLASP2 gene Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Indicus|evm.model.CM009512.1.55 Q8WUM4 PDC6I_HUMAN 95.429 0.997717 1.00922 PDCD6IP - Programmed cell death 6-interacting protein - Homo sapiens (Human) - PDCD6IP gene Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). Indicus|evm.model.CM009512.1.60 Q7M2N1 ARP21_BOVIN 100.000 0.102503 9.42697 ARPP21 - cAMP-regulated phosphoprotein 21 - Bos taurus (Bovine) - ARPP21 gene May act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. Indicus|evm.model.CM009512.1.62 A0JNJ1 STAC_BOVIN 85.360 0.99422 0.858561 STAC - SH3 and cysteine-rich domain-containing protein - Bos taurus (Bovine) - STAC gene Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. Indicus|evm.model.CM009512.1.63 Q2T9W6 LRRF2_BOVIN 99.500 0.995012 1.0025 LRRFIP2 - Leucine-rich repeat flightless-interacting protein 2 - Bos taurus (Bovine) - LRRFIP2 gene May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity). Indicus|evm.model.CM009512.1.64 P40692 MLH1_HUMAN 91.029 0.997365 1.00397 MLH1 - DNA mismatch repair protein Mlh1 - Homo sapiens (Human) - MLH1 gene Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. Indicus|evm.model.CM009512.1.65 Q7L775 EPMIP_HUMAN 83.882 0.996716 1.00329 EPM2AIP1 - EPM2A-interacting protein 1 - Homo sapiens (Human) - EPM2AIP1 gene identical protein binding, positive regulation of glycogen (starch) synthase activity, positive regulation of glycogen biosynthetic process, response to insulin Indicus|evm.model.CM009512.1.66 O15050 TRNK1_HUMAN 81.263 0.97596 1.02393 TRANK1 - TPR and ankyrin repeat-containing protein 1 - Homo sapiens (Human) - TRANK1 gene Indicus|evm.model.CM009512.1.67 Q9C098 DCLK3_HUMAN 77.414 0.808729 1.20216 DCLK3 - Serine/threonine-protein kinase DCLK3 - Homo sapiens (Human) - DCLK3 gene cytoplasm, nucleus, protein kinase activity, peptidyl-serine phosphorylation Indicus|evm.model.CM009512.1.69 Q13439 GOGA4_HUMAN 82.808 0.999111 1.00897 GOLGA4 - Golgin subfamily A member 4 - Homo sapiens (Human) - GOLGA4 gene Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). Indicus|evm.model.CM009512.1.70 Q13797 ITA9_HUMAN 87.479 0.96563 0.590338 ITGA9 - Integrin alpha-9 precursor - Homo sapiens (Human) - ITGA9 gene Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Indicus|evm.model.CM009512.1.71 Q13797 ITA9_HUMAN 92.157 0.34965 0.138164 ITGA9 - Integrin alpha-9 precursor - Homo sapiens (Human) - ITGA9 gene Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Indicus|evm.model.CM009512.1.72 P13620 ATP5H_BOVIN 84.821 0.982301 0.701863 ATP5PD - ATP synthase subunit d, mitochondrial - Bos taurus (Bovine) - ATP5PD gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Indicus|evm.model.CM009512.1.73 Q13797 ITA9_HUMAN 93.233 0.995 0.386473 ITGA9 - Integrin alpha-9 precursor - Homo sapiens (Human) - ITGA9 gene Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Indicus|evm.model.CM009512.1.75 O15194 CTDSL_HUMAN 97.211 0.961538 0.942029 CTDSPL - CTD small phosphatase-like protein - Homo sapiens (Human) - CTDSPL gene Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Indicus|evm.model.CM009512.1.76 O15195 VILL_HUMAN 74.048 0.997693 1.01285 VILL - Villin-like protein - Homo sapiens (Human) - VILL gene Possible tumor suppressor. Indicus|evm.model.CM009512.1.77 P10895 PLCD1_BOVIN 99.868 0.997358 1.00132 PLCD1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 - Bos taurus (Bovine) - PLCD1 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (By similarity). Indicus|evm.model.CM009512.1.78 Q9Y238 DLEC1_HUMAN 77.361 0.998283 0.995442 DLEC1 - Deleted in lung and esophageal cancer protein 1 - Homo sapiens (Human) - DLEC1 gene Essential for spermatogenesis and male fertility (By similarity). May play an important role in sperm head and tail formation (By similarity). May act as a tumor suppressor by inhibiting cell proliferation. Indicus|evm.model.CM009512.1.79 P09110 THIK_HUMAN 91.509 0.995294 1.00236 ACAA1 - 3-ketoacyl-CoA thiolase, peroxisomal precursor - Homo sapiens (Human) - ACAA1 gene Responsible for the thiolytic cleavage of straight chain 3-oxoacyl-CoAs. Catalyzes the cleavage of short, medium and long straight chain 3-oxoacyl-CoAs, medium chain 3-oxoacyl-CoAs being the best substrates. Indicus|evm.model.CM009512.1.80 Q599T9 MYD88_BOVIN 100.000 0.993266 1.00338 MYD88 - Myeloid differentiation primary response protein MyD88 - Bos taurus (Bovine) - MYD88 gene Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (PubMed:17936907, PubMed:18760477). Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). Indicus|evm.model.CM009512.1.81 Q5R495 OXSR1_PONAB 97.533 0.996212 1.0019 OXSR1 - Serine/threonine-protein kinase OSR1 - Pongo abelii (Sumatran orangutan) - OXSR1 gene Phosphorylates RELL1, RELL2, RELT and PAK1. Phosphorylates PLSCR1 in the presence of RELT. Indicus|evm.model.CM009512.1.82 Q9Y226 S22AD_HUMAN 76.190 0.244706 0.771325 SLC22A13 - Solute carrier family 22 member 13 - Homo sapiens (Human) - SLC22A13 gene apical plasma membrane, endoplasmic reticulum, extracellular exosome, Golgi apparatus, plasma membrane, nicotinate transmembrane transporter activity, NAD biosynthesis via nicotinamide riboside salvage pathway, negative regulation of fatty acid metabolic process, nicotinate transport, positive regulation of T cell mediated cytotoxicity directed against tumor cell target Indicus|evm.model.CM009512.1.83 Q9Y267 S22AE_HUMAN 60.924 0.930153 0.988215 SLC22A14 - Solute carrier family 22 member 14 - Homo sapiens (Human) - SLC22A14 gene Essential for male fertility, sperm motility and normal sperm flagellar structure. Indicus|evm.model.CM009512.1.84 Q3SYZ6 XYLB_BOVIN 99.583 0.891993 1.09592 XYLB - Xylulose kinase - Bos taurus (Bovine) - XYLB gene Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. Indicus|evm.model.CM009512.1.85 Q13705 AVR2B_HUMAN 98.394 0.925512 1.04883 ACVR2B - Activin receptor type-2B precursor - Homo sapiens (Human) - ACVR2B gene Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. Indicus|evm.model.CM009512.1.86 Q9Y2C4 EXOG_HUMAN 85.326 0.99458 1.00272 EXOG - Nuclease EXOG, mitochondrial precursor - Homo sapiens (Human) - EXOG gene Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity. Indicus|evm.model.CM009512.1.87 Q9JJV9 SCN5A_MOUSE 93.281 0.892763 1.12234 Scn5a - Sodium channel protein type 5 subunit alpha - Mus musculus (Mouse) - Scn5a gene This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:11834499, PubMed:23420830). It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (By similarity). Indicus|evm.model.CM009512.1.88 O46669 SCNAA_CANLF 84.275 0.991816 0.996432 SCN10A - Sodium channel protein type 10 subunit alpha - Canis lupus familiaris (Dog) - SCN10A gene Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity). Indicus|evm.model.CM009512.1.89 Q9UI33 SCNBA_HUMAN 76.442 0.998893 1.00838 SCN11A - Sodium channel protein type 11 subunit alpha - Homo sapiens (Human) - SCN11A gene This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Indicus|evm.model.CM009512.1.90 Q8TAF3 WDR48_HUMAN 99.852 0.99705 1.00148 WDR48 - WD repeat-containing protein 48 - Homo sapiens (Human) - WDR48 gene Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:31253762, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27650958, PubMed:27373336). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27650958, PubMed:27373336). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27463890, PubMed:27239033, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Indicus|evm.model.CM009512.1.91 Q9BQQ3 GORS1_HUMAN 81.236 0.957778 1.02273 GORASP1 - Golgi reassembly-stacking protein 1 - Homo sapiens (Human) - GORASP1 gene Plays an important role in assembly and membrane stacking of the Golgi cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (PubMed:26363069). Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). Indicus|evm.model.CM009512.1.92 Q8NDW8 TT21A_HUMAN 79.334 0.998445 0.974242 TTC21A - Tetratricopeptide repeat protein 21A - Homo sapiens (Human) - TTC21A gene Intraflagellar transport (IFT)-associated protein required for spermatogenesis (PubMed:30929735). Required for sperm flagellar formation and intraflagellar transport (PubMed:30929735). Indicus|evm.model.CM009512.1.93 Q96S65 CSRN1_HUMAN 82.939 0.996604 1 CSRNP1 - Cysteine/serine-rich nuclear protein 1 - Homo sapiens (Human) - CSRNP1 gene Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis. Indicus|evm.model.CM009512.1.94 O70373 XIRP1_MOUSE 74.582 0.611752 1.61293 Xirp1 - Xin actin-binding repeat-containing protein 1 - Mus musculus (Mouse) - Xirp1 gene Protects actin filaments from depolymerization. Indicus|evm.model.CM009512.1.95 A6QNL7 CX3C1_BOVIN 100.000 0.994429 1.00279 CX3CR1 - CX3C chemokine receptor 1 - Bos taurus (Bovine) - CX3CR1 gene Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung. Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells. Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis. Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation. Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli. Involved in brain development by participating to synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development. Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development. Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi. Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria. Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (By similarity). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity). Indicus|evm.model.CM009512.1.96 Q9JM95 SIA7F_MOUSE 78.846 0.189723 0.75976 St6galnac6 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 - Mus musculus (Mouse) - St6galnac6 gene Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (PubMed:10702226). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (By similarity). Indicus|evm.model.CM009512.1.97 O97665 CCR8_MACMU 81.461 0.994334 0.991573 CCR8 - C-C chemokine receptor type 8 - Macaca mulatta (Rhesus macaque) - CCR8 gene Receptor for the chemokines CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis (By similarity). Indicus|evm.model.CM009512.1.98 Q5EAC0 S2538_BOVIN 99.346 0.585413 1.70261 SLC25A38 - Mitochondrial glycine transporter - Bos taurus (Bovine) - SLC25A38 gene Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. Indicus|evm.model.CM009512.1.100 P26452 RSSA_BOVIN 100.000 0.993243 1.00339 RPSA - 40S ribosomal protein SA - Bos taurus (Bovine) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. Indicus|evm.model.CM009512.1.102 Q63327 MOBP_RAT 98.551 0.596491 0.670588 Mobp - Myelin-associated oligodendrocyte basic protein - Rattus norvegicus (Rat) - Mobp gene May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane. Indicus|evm.model.CM009512.1.104 Q8NFW9 MYRIP_HUMAN 83.628 0.907427 1.08149 MYRIP - Rab effector MyRIP - Homo sapiens (Human) - MYRIP gene Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). Indicus|evm.model.CM009512.1.105 P61220 EIF1B_PIG 100.000 0.982456 1.00885 EIF1B - Eukaryotic translation initiation factor 1b - Sus scrofa (Pig) - EIF1B gene Probably involved in translation. Indicus|evm.model.CM009512.1.106 O75355 ENTP3_HUMAN 79.584 0.996226 1.00189 ENTPD3 - Ectonucleoside triphosphate diphosphohydrolase 3 - Homo sapiens (Human) - ENTPD3 gene Has a threefold preference for the hydrolysis of ATP over ADP. Indicus|evm.model.CM009512.1.107 Q3T0U2 RL14_BOVIN 99.533 0.990654 1 RPL14 - 60S ribosomal protein L14 - Bos taurus (Bovine) - RPL14 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009512.1.108 Q8N2I2 ZN619_HUMAN 78.351 0.994859 0.694643 ZNF619 - Zinc finger protein 619 - Homo sapiens (Human) - ZNF619 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009512.1.109 Q6ZSS3 ZN621_HUMAN 70.481 0.957143 0.95672 ZNF621 - Zinc finger protein 621 - Homo sapiens (Human) - ZNF621 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009512.1.110 Q6ZSS3 ZN621_HUMAN 82.380 0.96 1.02506 ZNF621 - Zinc finger protein 621 - Homo sapiens (Human) - ZNF621 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009512.1.111 P31081 CH60_BOVIN 100.000 0.996516 1.00175 HSPD1 - 60 kDa heat shock protein, mitochondrial precursor - Bos taurus (Bovine) - HSPD1 gene Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. Indicus|evm.model.CM009512.1.113 B6V8E6 CTNB1_CANLF 100.000 0.997442 1.00128 CTNNB1 - Catenin beta-1 - Canis lupus familiaris (Dog) - CTNNB1 gene Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Indicus|evm.model.CM009512.1.114 Q5R4M2 ULK4_PONAB 85.577 0.920327 0.767843 ULK4 - Serine/threonine-protein kinase ULK4 - Pongo abelii (Sumatran orangutan) - ULK4 gene May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility. Indicus|evm.model.CM009512.1.115 Q5RBI4 ABHD5_PONAB 95.129 0.994269 1 ABHD5 - 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 - Pongo abelii (Sumatran orangutan) - ABHD5 gene Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (By similarity). Involved in keratinocyte differentiation (By similarity). Regulates lipid droplet fusion (By similarity). Indicus|evm.model.CM009512.1.116 P49914 MTHFS_HUMAN 65.500 0.938889 0.8867 MTHFS - 5-formyltetrahydrofolate cyclo-ligase - Homo sapiens (Human) - MTHFS gene Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. Indicus|evm.model.CM009512.1.117 Q8N6M0 OTU6B_HUMAN 88.737 0.993174 1 OTUD6B - Deubiquitinase OTUD6B - Homo sapiens (Human) - OTUD6B gene Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629). Indicus|evm.model.CM009512.1.118 Q96C45 ULK4_HUMAN 91.322 0.979675 0.192941 ULK4 - Serine/threonine-protein kinase ULK4 - Homo sapiens (Human) - ULK4 gene May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility. Indicus|evm.model.CM009512.1.119 Q6PD31 TRAK1_MOUSE 91.549 0.351759 0.211928 Trak1 - Trafficking kinesin-binding protein 1 - Mus musculus (Mouse) - Trak1 gene Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (By similarity). Involved in mitochondrial motility (PubMed:24995978). When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (By similarity). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). Indicus|evm.model.CM009512.1.120 Q9UPV9 TRAK1_HUMAN 85.897 0.985961 0.971668 TRAK1 - Trafficking kinesin-binding protein 1 - Homo sapiens (Human) - TRAK1 gene Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). Indicus|evm.model.CM009512.1.121 P41520 CCKN_BOVIN 100.000 0.982759 1.0087 CCK - Cholecystokinin precursor - Bos taurus (Bovine) - CCK gene This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. Indicus|evm.model.CM009512.1.122 Q2T9N7 LYZL4_BOVIN 100.000 0.986301 1.0069 LYZL4 - Lysozyme-like protein 4 precursor - Bos taurus (Bovine) - LYZL4 gene May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity). Indicus|evm.model.CM009512.1.123 Q28992 VIPR1_PIG 89.107 0.995652 1.00437 VIPR1 - Vasoactive intestinal polypeptide receptor 1 precursor - Sus scrofa (Pig) - VIPR1 gene This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Indicus|evm.model.CM009512.1.124 Q2YDJ2 SC22C_BOVIN 100.000 0.993421 1.0033 SEC22C - Vesicle-trafficking protein SEC22c - Bos taurus (Bovine) - SEC22C gene May be involved in vesicle transport between the ER and the Golgi complex. Indicus|evm.model.CM009512.1.125 Q9UFB7 ZBT47_HUMAN 93.931 0.152271 3.00669 ZBTB47 - Zinc finger and BTB domain-containing protein 47 - Homo sapiens (Human) - ZBTB47 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009512.1.126 Q2TBA0 KLH40_HUMAN 86.328 0.99681 1.00966 KLHL40 - Kelch-like protein 40 - Homo sapiens (Human) - KLHL40 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity). Indicus|evm.model.CM009512.1.127 Q9HCP6 HHATL_HUMAN 81.746 0.995565 0.894841 HHATL - Protein-cysteine N-palmitoyltransferase HHAT-like protein - Homo sapiens (Human) - HHATL gene Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN. Indicus|evm.model.CM009512.1.128 Q8IYE1 CCD13_HUMAN 85.994 0.995804 1 CCDC13 - Coiled-coil domain-containing protein 13 - Homo sapiens (Human) - CCDC13 gene Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia. Indicus|evm.model.CM009512.1.129 Q8VH49 HIG1A_RAT 87.097 0.867925 1.13978 Higd1a - HIG1 domain family member 1A, mitochondrial - Rattus norvegicus (Rat) - Higd1a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Indicus|evm.model.CM009512.1.130 O00590 ACKR2_HUMAN 79.112 0.976623 1.0026 ACKR2 - Atypical chemokine receptor 2 - Homo sapiens (Human) - ACKR2 gene Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs. Indicus|evm.model.CM009512.1.132 Q7YRB2 CP8B1_PIG 86.228 0.996 0.998004 CYP8B1 - 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase - Sus scrofa (Pig) - CYP8B1 gene A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis (PubMed:14643796). Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (By similarity). Indicus|evm.model.CM009512.1.134 Q9UFP1 GAK1A_HUMAN 86.986 0.960265 0.262609 GASK1A - Golgi-associated kinase 1A precursor - Homo sapiens (Human) - GASK1A gene endoplasmic reticulum, extracellular region, Golgi apparatus, intracellular membrane-bounded organelle Indicus|evm.model.CM009512.1.135 Q5NDF2 PMGT2_BOVIN 100.000 0.996558 1.00172 POMGNT2 - Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 - Bos taurus (Bovine) - POMGNT2 gene O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Indicus|evm.model.CM009512.1.136 Q9NRH2 SNRK_HUMAN 93.594 0.746667 0.980392 SNRK - SNF-related serine/threonine-protein kinase - Homo sapiens (Human) - SNRK gene May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. Indicus|evm.model.CM009512.1.137 Q9NW15 ANO10_HUMAN 85.452 0.953674 0.948485 ANO10 - Anoctamin-10 - Homo sapiens (Human) - ANO10 gene Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. Indicus|evm.model.CM009512.1.138 G7H7V7 TOPZ1_BOVIN 99.879 0.998791 1.0006 TOPAZ1 - Protein TOPAZ1 - Bos taurus (Bovine) - TOPAZ1 gene Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear. Indicus|evm.model.CM009512.1.139 Q8N3R3 TCAIM_HUMAN 92.339 0.995976 1.00202 TCAIM - T-cell activation inhibitor, mitochondrial - Homo sapiens (Human) - TCAIM gene May regulate T-cell apoptosis. Indicus|evm.model.CM009512.1.140 P0DN24 CC086_HUMAN 53.333 0.509901 2 C3orf86 - Uncharacterized protein C3orf86 - Homo sapiens (Human) - C3orf86 gene Indicus|evm.model.CM009512.1.141 Q2HJI3 F136A_BOVIN 88.406 0.985612 1.00725 FAM136A - Protein FAM136A - Bos taurus (Bovine) - FAM136A gene cytoplasm Indicus|evm.model.CM009512.1.142 P59923 ZN445_HUMAN 76.864 0.998054 0.99709 ZNF445 - Zinc finger protein 445 - Homo sapiens (Human) - ZNF445 gene Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). Indicus|evm.model.CM009512.1.143 Q9P0L1 ZKSC7_HUMAN 81.675 0.703704 0.35809 ZKSCAN7 - Zinc finger protein with KRAB and SCAN domains 7 - Homo sapiens (Human) - ZKSCAN7 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009512.1.144 Q9P0L1 ZKSC7_HUMAN 84.342 0.995833 0.636605 ZKSCAN7 - Zinc finger protein with KRAB and SCAN domains 7 - Homo sapiens (Human) - ZKSCAN7 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009512.1.145 Q6AZW8 ZN660_HUMAN 93.353 0.993884 0.987915 ZNF660 - Zinc finger protein 660 - Homo sapiens (Human) - ZNF660 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009512.1.146 O14709 ZN197_HUMAN 91.338 0.995202 1.01263 ZNF197 - Zinc finger protein 197 - Homo sapiens (Human) - ZNF197 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009512.1.147 P13682 ZNF35_HUMAN 88.994 0.992453 1.00569 ZNF35 - Zinc finger protein 35 - Homo sapiens (Human) - ZNF35 gene May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation. Indicus|evm.model.CM009512.1.148 Q8TBZ5 ZN502_HUMAN 87.908 0.994231 0.955882 ZNF502 - Zinc finger protein 502 - Homo sapiens (Human) - ZNF502 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009512.1.149 Q3MHJ0 K1143_BOVIN 99.359 0.987261 1.00641 Uncharacterized protein KIAA1143 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009512.1.150 Q9NS87 KIF15_HUMAN 88.180 0.950345 1.04467 KIF15 - Kinesin-like protein KIF15 - Homo sapiens (Human) - KIF15 gene Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. Indicus|evm.model.CM009512.1.152 Q93075 TATD2_HUMAN 76.554 0.997326 0.982917 TATDN2 - Putative deoxyribonuclease TATDN2 - Homo sapiens (Human) - TATDN2 gene Putative deoxyribonuclease. Indicus|evm.model.CM009512.1.153 Q0P5I2 IRAK2_BOVIN 99.839 0.996785 1.00161 IRAK2 - Interleukin-1 receptor-associated kinase-like 2 - Bos taurus (Bovine) - IRAK2 gene Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Indicus|evm.model.CM009512.1.154 Q5Q9Z2 VHL_CANLF 84.974 0.979381 0.885845 VHL - von Hippel-Lindau disease tumor suppressor - Canis lupus familiaris (Dog) - VHL gene Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (By similarity). Indicus|evm.model.CM009512.1.155 Q6IQ86 BRK1_DANRE 100.000 0.973684 1.01333 brk1 - Probable protein BRICK1 - Danio rerio (Zebrafish) - brk1 gene Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity). Indicus|evm.model.CM009512.1.156 Q32KZ5 FACOS_BOVIN 99.438 0.988827 1.00562 FANCD2OS - FANCD2 opposite strand protein - Bos taurus (Bovine) - FANCD2OS gene Indicus|evm.model.CM009512.1.157 Q9BXW9 FACD2_HUMAN 80.929 0.991655 0.991041 FANCD2 - Fanconi anemia group D2 protein - Homo sapiens (Human) - FANCD2 gene Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. Indicus|evm.model.CM009512.1.158 Q3ZCB8 EMC3_BOVIN 93.487 0.992366 1.00383 EMC3 - ER membrane protein complex subunit 3 - Bos taurus (Bovine) - EMC3 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Indicus|evm.model.CM009512.1.159 Q5FWE3 PRRT3_HUMAN 80.366 0.956863 1.03976 PRRT3 - Proline-rich transmembrane protein 3 precursor - Homo sapiens (Human) - PRRT3 gene Indicus|evm.model.CM009512.1.160 Q5EA46 CREL1_BOVIN 99.762 0.995249 1.00238 CRELD1 - Protein disulfide isomerase CRELD1 precursor - Bos taurus (Bovine) - CRELD1 gene Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity). Indicus|evm.model.CM009512.1.161 Q8NAC3 I17RC_HUMAN 85.714 0.0474198 0.906448 IL17RC - Interleukin-17 receptor C precursor - Homo sapiens (Human) - IL17RC gene Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:16785495, PubMed:32187518). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:18684971, PubMed:17911633). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Indicus|evm.model.CM009512.1.162 Q8NFR9 I17RE_HUMAN 77.083 0.995208 0.938531 IL17RE - Interleukin-17 receptor E precursor - Homo sapiens (Human) - IL17RE gene Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. Indicus|evm.model.CM009512.1.163 Q2NKY9 JAGN1_BOVIN 100.000 0.98913 1.00546 JAGN1 - Protein jagunal homolog 1 - Bos taurus (Bovine) - JAGN1 gene Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. Indicus|evm.model.CM009512.1.164 F1MN90 CIDEC_BOVIN 98.649 0.928571 1.07207 CIDEC - Cell death activator CIDE-3 - Bos taurus (Bovine) - CIDEC gene Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. The physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression (By similarity). Indicus|evm.model.CM009512.1.165 Q2TBK7 RUSD3_BOVIN 99.709 0.994203 1.00291 RPUSD3 - Mitochondrial mRNA pseudouridine synthase RPUSD3 precursor - Bos taurus (Bovine) - RPUSD3 gene Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis. Indicus|evm.model.CM009512.1.166 A4Q9E5 TTLL3_MOUSE 85.197 0.9 0.755124 Ttll3 - Tubulin monoglycylase TTLL3 - Mus musculus (Mouse) - Ttll3 gene Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction. Indicus|evm.model.CM009512.1.167 P59999 ARPC4_MOUSE 100.000 0.988166 1.00595 Arpc4 - Actin-related protein 2/3 complex subunit 4 - Mus musculus (Mouse) - Arpc4 gene Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Indicus|evm.model.CM009512.1.168 O75528 TADA3_HUMAN 98.182 0.995465 1.02083 TADA3 - Transcriptional adapter 3 - Homo sapiens (Human) - TADA3 gene Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Indicus|evm.model.CM009512.1.169 Q63450 KCC1A_RAT 96.961 0.973046 0.991979 Camk1 - Calcium/calmodulin-dependent protein kinase type 1 - Rattus norvegicus (Rat) - Camk1 gene Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-516', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation (By similarity). Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-275' and 'Ser-294'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. Indicus|evm.model.CM009512.1.170 O15527 OGG1_HUMAN 86.377 0.988506 1.0087 OGG1 - N-glycosylase/DNA lyase - Homo sapiens (Human) - OGG1 gene DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Indicus|evm.model.CM009512.1.171 P55201 BRPF1_HUMAN 98.847 0.991006 1.00741 BRPF1 - Peregrin - Homo sapiens (Human) - BRPF1 gene Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). Indicus|evm.model.CM009512.1.173 Q8IYJ1 CPNE9_HUMAN 98.553 0.996383 1 CPNE9 - Copine-9 - Homo sapiens (Human) - CPNE9 gene Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Indicus|evm.model.CM009512.1.174 Q8NCE2 MTMRE_HUMAN 93.301 0.963077 1 MTMR14 - Myotubularin-related protein 14 - Homo sapiens (Human) - MTMR14 gene Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Indicus|evm.model.CM009512.1.175 Q17R16 LHPL4_BOVIN 100.000 0.772727 0.623482 LHFPL4 - LHFPL tetraspan subfamily member 4 protein - Bos taurus (Bovine) - LHFPL4 gene Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. Indicus|evm.model.CM009512.1.176 Q9C0A6 SETD5_HUMAN 93.952 0.998624 1.00763 SETD5 - Histone-lysine N-methyltransferase SETD5 - Homo sapiens (Human) - SETD5 gene Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. Indicus|evm.model.CM009512.1.177 Q2T9W2 THUM3_BOVIN 99.801 0.994048 0.996047 THUMPD3 - THUMP domain-containing protein 3 - Bos taurus (Bovine) - THUMPD3 gene Indicus|evm.model.CM009512.1.178 O43295 SRGP3_HUMAN 99.181 0.998182 1.00091 SRGAP3 - SLIT-ROBO Rho GTPase-activating protein 3 - Homo sapiens (Human) - SRGAP3 gene GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. Indicus|evm.model.CM009512.1.179 Q9NS91 RAD18_HUMAN 81.710 0.996016 1.01414 RAD18 - E3 ubiquitin-protein ligase RAD18 - Homo sapiens (Human) - RAD18 gene E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. Indicus|evm.model.CM009512.1.180 P56449 OXYR_BOVIN 100.000 0.994898 1.00256 OXTR - Oxytocin receptor - Bos taurus (Bovine) - OXTR gene Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009512.1.181 Q2KI43 CAV3_BOVIN 100.000 0.986842 1.00662 CAV3 - Caveolin-3 - Bos taurus (Bovine) - CAV3 gene May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. Indicus|evm.model.CM009512.1.182 Q9Y2M2 SSUH2_HUMAN 84.049 0.771971 1.19263 SSUH2 - Protein SSUH2 homolog - Homo sapiens (Human) - SSUH2 gene Plays a role in odontogenesis. Indicus|evm.model.CM009512.1.183 Q17QE2 LMCD1_BOVIN 99.725 0.994505 1.00275 LMCD1 - LIM and cysteine-rich domains protein 1 - Bos taurus (Bovine) - LMCD1 gene Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway (By similarity). Indicus|evm.model.CM009512.1.186 Q5RDQ8 GRM7_PONAB 98.795 0.427083 0.208243 GRM7 - Metabotropic glutamate receptor 7 precursor - Pongo abelii (Sumatran orangutan) - GRM7 gene G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (By similarity). Indicus|evm.model.CM009512.1.187 Q14831 GRM7_HUMAN 99.320 0.915625 0.349727 GRM7 - Metabotropic glutamate receptor 7 precursor - Homo sapiens (Human) - GRM7 gene G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed:9473604). Indicus|evm.model.CM009512.1.188 Q68ED2 GRM7_MOUSE 99.383 0.636364 0.276503 Grm7 - Metabotropic glutamate receptor 7 precursor - Mus musculus (Mouse) - Grm7 gene G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (By similarity). Indicus|evm.model.CM009512.1.189 P35400 GRM7_RAT 97.959 0.740458 0.143169 Grm7 - Metabotropic glutamate receptor 7 precursor - Rattus norvegicus (Rat) - Grm7 gene G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits. Indicus|evm.model.CM009512.1.190 P35400 GRM7_RAT 98.851 0.961111 0.196721 Grm7 - Metabotropic glutamate receptor 7 precursor - Rattus norvegicus (Rat) - Grm7 gene G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits. Indicus|evm.model.CM009512.1.192 Q92611 EDEM1_HUMAN 95.137 0.996965 1.00304 EDEM1 - ER degradation-enhancing alpha-mannosidase-like protein 1 - Homo sapiens (Human) - EDEM1 gene Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. Indicus|evm.model.CM009512.1.193 Q66HA6 ARL8B_RAT 100.000 0.748988 1.32796 Arl8b - ADP-ribosylation factor-like protein 8B - Rattus norvegicus (Rat) - Arl8b gene Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion. Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense. Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes. Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (By similarity). Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity). May play a role in chromosome segregation (By similarity). Indicus|evm.model.CM009512.1.194 Q5EA15 BHE40_BOVIN 100.000 0.995157 1.00243 BHLHE40 - Class E basic helix-loop-helix protein 40 - Bos taurus (Bovine) - BHLHE40 gene Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (By similarity). Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-ARNTL/BMAL1 complex (By similarity). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (By similarity). Indicus|evm.model.CM009512.1.195 Q9TU34 ITPR1_BOVIN 98.931 0.999263 1.00221 ITPR1 - Inositol 1,4,5-trisphosphate receptor type 1 - Bos taurus (Bovine) - ITPR1 gene Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Indicus|evm.model.CM009512.1.196 Q0P5L5 SUMF1_BOVIN 99.733 0.994667 1.00267 SUMF1 - Formylglycine-generating enzyme precursor - Bos taurus (Bovine) - SUMF1 gene Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. Indicus|evm.model.CM009512.1.197 P60897 SEM1_MOUSE 100.000 0.971831 1.01429 Sem1 - 26S proteasome complex subunit SEM1 - Mus musculus (Mouse) - Sem1 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells. Indicus|evm.model.CM009512.1.198 Q0VD24 SETMR_BOVIN 99.673 0.993485 1.00327 SETMAR - Histone-lysine N-methyltransferase SETMAR - Bos taurus (Bovine) - SETMAR gene Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Indicus|evm.model.CM009512.1.199 A0N0X6 LRRN1_BOVIN 100.000 0.997211 1.0014 LRRN1 - Leucine-rich repeat neuronal protein 1 precursor - Bos taurus (Bovine) - LRRN1 gene extracellular matrix, extracellular space Indicus|evm.model.CM009512.1.200 Q0P564 CRBN_BOVIN 100.000 0.995506 1.00225 CRBN - Protein cereblon - Bos taurus (Bovine) - CRBN gene Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity). Indicus|evm.model.CM009512.1.201 Q8K1J6 TRNT1_MOUSE 91.475 0.995402 1.0023 Trnt1 - CCA tRNA nucleotidyltransferase 1, mitochondrial precursor - Mus musculus (Mouse) - Trnt1 gene Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. Indicus|evm.model.CM009512.1.202 Q01344 IL5RA_HUMAN 74.745 0.946731 0.983333 IL5RA - Interleukin-5 receptor subunit alpha precursor - Homo sapiens (Human) - IL5RA gene This is the receptor for interleukin-5. The alpha chain binds to IL5. Indicus|evm.model.CM009512.1.204 Q9UQ52 CNTN6_HUMAN 64.678 0.89083 0.891051 CNTN6 - Contactin-6 precursor - Homo sapiens (Human) - CNTN6 gene Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity). Indicus|evm.model.CM009512.1.205 A6NDY0 EPAB2_HUMAN 69.504 0.992674 0.982014 PABPN1L - Embryonic polyadenylate-binding protein 2 - Homo sapiens (Human) - PABPN1L gene Binds the poly(A) tail of mRNA. Indicus|evm.model.CM009512.1.206 O00533 NCHL1_HUMAN 88.408 0.998369 1.0149 CHL1 - Neural cell adhesion molecule L1-like protein precursor - Homo sapiens (Human) - CHL1 gene Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). Indicus|evm.model.CM009512.1.207 Q9P232 CNTN3_HUMAN 89.952 0.526718 0.764591 CNTN3 - Contactin-3 precursor - Homo sapiens (Human) - CNTN3 gene Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity). Indicus|evm.model.CM009512.1.208 Q9UPQ7 PZRN3_HUMAN 92.710 0.998117 0.996248 PDZRN3 - E3 ubiquitin-protein ligase PDZRN3 - Homo sapiens (Human) - PDZRN3 gene E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. Indicus|evm.model.CM009512.1.209 Q9NY27 PP4R2_HUMAN 92.326 0.995157 0.990408 PPP4R2 - Serine/threonine-protein phosphatase 4 regulatory subunit 2 - Homo sapiens (Human) - PPP4R2 gene Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. Indicus|evm.model.CM009512.1.210 A0PJZ3 GXLT2_HUMAN 96.338 0.934037 0.85553 GXYLT2 - Glucoside xylosyltransferase 2 - Homo sapiens (Human) - GXYLT2 gene Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose. Indicus|evm.model.CM009512.1.211 Q3MHH1 SHQ1_BOVIN 92.480 0.996805 1.08117 SHQ1 - Protein SHQ1 homolog - Bos taurus (Bovine) - SHQ1 gene Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. Indicus|evm.model.CM009512.1.212 Q8N488 RYBP_HUMAN 94.149 0.781116 1.02193 RYBP - RING1 and YY1-binding protein - Homo sapiens (Human) - RYBP gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). Indicus|evm.model.CM009512.1.216 Q8N5X7 IF4E3_HUMAN 98.795 0.887097 0.830357 EIF4E3 - Eukaryotic translation initiation factor 4E type 3 - Homo sapiens (Human) - EIF4E3 gene Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity). Indicus|evm.model.CM009512.1.217 A4IFD2 FOXP1_BOVIN 99.838 0.923423 0.988131 FOXP1 - Forkhead box protein P1 - Bos taurus (Bovine) - FOXP1 gene Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (By similarity). Indicus|evm.model.CM009512.1.218 A0A1B0GVS7 MDFI2_HUMAN 81.287 0.982456 0.904762 MDFIC2 - MyoD family inhibitor domain-containing protein 2 - Homo sapiens (Human) - MDFIC2 gene Indicus|evm.model.CM009512.1.219 O75030 MITF_HUMAN 96.578 0.996161 0.990494 MITF - Microphthalmia-associated transcription factor - Homo sapiens (Human) - MITF gene Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Indicus|evm.model.CM009512.1.220 Q8WUD1 RAB2B_HUMAN 67.910 0.891892 0.685185 RAB2B - Ras-related protein Rab-2B - Homo sapiens (Human) - RAB2B gene Required for protein transport from the endoplasmic reticulum to the Golgi complex. Indicus|evm.model.CM009512.1.221 Q9Y2L6 FRM4B_HUMAN 93.816 0.998069 1.00193 FRMD4B - FERM domain-containing protein 4B - Homo sapiens (Human) - FRMD4B gene Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. Indicus|evm.model.CM009512.1.222 Q0VAK6 LMOD3_HUMAN 83.957 0.984155 1.01429 LMOD3 - Leiomodin-3 - Homo sapiens (Human) - LMOD3 gene Essential for the organization of sarcomeric actin thin filaments in skeletal muscle (PubMed:25250574). Increases the rate of actin polymerization (PubMed:25250574). Indicus|evm.model.CM009512.1.223 Q5E9M1 PRAF3_BOVIN 100.000 0.989418 1.00532 ARL6IP5 - PRA1 family protein 3 - Bos taurus (Bovine) - ARL6IP5 gene Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum. Indicus|evm.model.CM009512.1.224 Q8TBC4 UBA3_HUMAN 98.920 0.99569 1.00216 UBA3 - NEDD8-activating enzyme E1 catalytic subunit - Homo sapiens (Human) - UBA3 gene Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. Indicus|evm.model.CM009512.1.225 P82094 TMF1_HUMAN 92.681 0.99817 1 TMF1 - TATA element modulatory factor - Homo sapiens (Human) - TMF1 gene Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). Indicus|evm.model.CM009512.1.226 A0JND3 EOGT_BOVIN 100.000 0.996212 1.0019 EOGT - EGF domain-specific O-linked N-acetylglucosamine transferase precursor - Bos taurus (Bovine) - EOGT gene Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Indicus|evm.model.CM009512.1.227 Q7TPG8 TAFA1_MOUSE 100.000 0.839286 0.842105 Tafa1 - Chemokine-like protein TAFA-1 precursor - Mus musculus (Mouse) - Tafa1 gene Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Indicus|evm.model.CM009512.1.228 Q8NHQ8 RASF8_HUMAN 93.137 0.89823 0.539379 RASSF8 - Ras association domain-containing protein 8 - Homo sapiens (Human) - RASSF8 gene Indicus|evm.model.CM009512.1.229 Q3MHX5 SUCB2_BOVIN 99.752 0.995062 0.9375 SUCLG2 - Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial precursor - Bos taurus (Bovine) - SUCLG2 gene GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Indicus|evm.model.CM009512.1.230 Q8NFY9 KBTB8_HUMAN 98.170 0.996678 1.00166 KBTBD8 - Kelch repeat and BTB domain-containing protein 8 - Homo sapiens (Human) - KBTBD8 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Indicus|evm.model.CM009512.1.231 Q96JA1 LRIG1_HUMAN 82.188 0.998167 0.99817 LRIG1 - Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor - Homo sapiens (Human) - LRIG1 gene Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. Indicus|evm.model.CM009512.1.232 A6QR09 SAMC_BOVIN 99.270 0.992727 1.00365 SLC25A26 - S-adenosylmethionine mitochondrial carrier protein - Bos taurus (Bovine) - SLC25A26 gene Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity). Indicus|evm.model.CM009512.1.233 Q920A7 AFG31_MOUSE 77.848 0.844086 0.235741 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Indicus|evm.model.CM009512.1.236 Q2TBN4 MED28_BOVIN 92.763 0.877907 0.966292 MED28 - Mediator of RNA polymerase II transcription subunit 28 - Bos taurus (Bovine) - MED28 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity). Indicus|evm.model.CM009512.1.238 Q9P2N4 ATS9_HUMAN 92.458 0.998813 0.870801 ADAMTS9 - A disintegrin and metalloproteinase with thrombospondin motifs 9 precursor - Homo sapiens (Human) - ADAMTS9 gene Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. Indicus|evm.model.CM009512.1.240 Q7Z3G6 PRIC2_HUMAN 95.379 0.9547 1.04621 PRICKLE2 - Prickle-like protein 2 precursor - Homo sapiens (Human) - PRICKLE2 gene cytoplasm, Wnt signaling pathway, planar cell polarity pathway Indicus|evm.model.CM009512.1.241 Q3T0B2 PSMD6_BOVIN 99.743 0.994872 1.00257 PSMD6 - 26S proteasome non-ATPase regulatory subunit 6 - Bos taurus (Bovine) - PSMD6 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Indicus|evm.model.CM009512.1.242 O15265 ATX7_HUMAN 88.933 0.976774 0.868834 ATXN7 - Ataxin-7 - Homo sapiens (Human) - ATXN7 gene Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization. Indicus|evm.model.CM009512.1.243 Q6I9Y2 THOC7_HUMAN 99.495 0.9801 0.985294 THOC7 - THO complex subunit 7 homolog - Homo sapiens (Human) - THOC7 gene Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Indicus|evm.model.CM009512.1.244 Q96BT1 CC049_HUMAN 70.280 0.964413 0.962329 C3orf49 - Putative uncharacterized protein C3orf49 - Homo sapiens (Human) - C3orf49 gene Indicus|evm.model.CM009512.1.246 Q0P561 SNTAN_BOVIN 89.815 0.492823 1.42177 SNTN - Sentan - Bos taurus (Bovine) - SNTN gene May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules. Indicus|evm.model.CM009512.1.247 Q8TBG9 SYNPR_HUMAN 93.774 0.870748 1.10943 SYNPR - Synaptoporin - Homo sapiens (Human) - SYNPR gene Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity). Indicus|evm.model.CM009512.1.249 Q80TJ1 CAPS1_MOUSE 98.246 0.8 0.0516605 Cadps - Calcium-dependent secretion activator 1 - Mus musculus (Mouse) - Cadps gene Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). Indicus|evm.model.CM009512.1.250 Q9ULU8 CAPS1_HUMAN 96.944 0.992593 0.798226 CADPS - Calcium-dependent secretion activator 1 - Homo sapiens (Human) - CADPS gene Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). Indicus|evm.model.CM009512.1.251 Q2VWH6 FEZF2_BOVIN 99.564 0.995652 1.00437 FEZF2 - Fez family zinc finger protein 2 - Bos taurus (Bovine) - FEZF2 gene Transcription repressor. Binds to 5'GCAG-3' core sequence. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons (By similarity). May be responsible for mastitis resistance and innate immunity. Indicus|evm.model.CM009512.1.252 Q29S20 CC014_BOVIN 99.219 0.984496 1.00781 Uncharacterized protein C3orf14 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009512.1.253 P23470 PTPRG_HUMAN 86.874 0.996476 0.785467 PTPRG - Receptor-type tyrosine-protein phosphatase gamma precursor - Homo sapiens (Human) - PTPRG gene Possesses tyrosine phosphatase activity. Indicus|evm.model.CM009512.1.254 P23470 PTPRG_HUMAN 88.793 0.583756 0.136332 PTPRG - Receptor-type tyrosine-protein phosphatase gamma precursor - Homo sapiens (Human) - PTPRG gene Possesses tyrosine phosphatase activity. Indicus|evm.model.CM009512.1.255 Q9NUJ7 PLCX1_HUMAN 50.336 0.98 0.773994 PLCXD1 - PI-PLC X domain-containing protein 1 - Homo sapiens (Human) - PLCXD1 gene Indicus|evm.model.CM009512.1.256 Q13796 SHRM2_HUMAN 65.591 0.884615 0.0643564 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Indicus|evm.model.CM009512.1.258 Q98936 PTPRG_CHICK 73.333 0.173913 0.177918 PTPRG - Receptor-type tyrosine-protein phosphatase gamma precursor - Gallus gallus (Chicken) - PTPRG gene Indicus|evm.model.CM009512.1.261 Q1KZG4 FHIT_BOVIN 100.000 0.860215 0.624161 FHIT - Bis(5'-adenosyl)-triphosphatase - Bos taurus (Bovine) - FHIT gene Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity. Functions as tumor suppressor (By similarity). Indicus|evm.model.CM009512.1.262 Q95JY0 CF20D_MACFA 78.261 0.84398 1.18142 CFAP20DC - Protein CFAP20DC - Macaca fascicularis (Crab-eating macaque) - CFAP20DC gene Indicus|evm.model.CM009512.1.264 Q96BQ1 FAM3D_HUMAN 73.423 0.986607 1 FAM3D - Protein FAM3D precursor - Homo sapiens (Human) - FAM3D gene extracellular region, extracellular space, cytokine activity, negative regulation of insulin secretion Indicus|evm.model.CM009512.1.267 Q5NVP3 F107A_PONAB 95.833 0.986207 1.00694 FAM107A - Actin-associated protein FAM107A - Pongo abelii (Sumatran orangutan) - FAM107A gene Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development (By similarity). Indicus|evm.model.CM009512.1.268 Q99424 ACOX2_HUMAN 80.147 0.994143 1.00294 ACOX2 - Peroxisomal acyl-coenzyme A oxidase 2 - Homo sapiens (Human) - ACOX2 gene Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids (PubMed:27884763). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). Indicus|evm.model.CM009512.1.269 Q8NC69 KCTD6_HUMAN 99.578 0.991597 1.00422 KCTD6 - BTB/POZ domain-containing protein KCTD6 - Homo sapiens (Human) - KCTD6 gene Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887). Indicus|evm.model.CM009512.1.270 P11966 ODPB_BOVIN 100.000 0.994444 1.00279 PDHB - Pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor - Bos taurus (Bovine) - PDHB gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Indicus|evm.model.CM009512.1.271 Q7Z7A4 PXK_HUMAN 96.386 0.996564 1.00692 PXK - PX domain-containing protein kinase-like protein - Homo sapiens (Human) - PXK gene Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. Indicus|evm.model.CM009512.1.272 P86397 HTD2_HUMAN 84.524 0.988166 1.00595 HTD2 - Hydroxyacyl-thioester dehydratase type 2, mitochondrial precursor - Homo sapiens (Human) - HTD2 gene Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis. Indicus|evm.model.CM009512.1.273 Q5RB79 RPP14_PONAB 92.742 0.984 1.00806 RPP14 - Ribonuclease P protein subunit p14 - Pongo abelii (Sumatran orangutan) - RPP14 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Indicus|evm.model.CM009512.1.274 Q1LZ86 ABHD6_BOVIN 100.000 0.994083 1.00297 ABHD6 - Monoacylglycerol lipase ABHD6 - Bos taurus (Bovine) - ABHD6 gene Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (By similarity). Indicus|evm.model.CM009512.1.275 O89107 DNSL3_RAT 85.965 0.928105 0.987097 Dnase1l3 - Deoxyribonuclease gamma precursor - Rattus norvegicus (Rat) - Dnase1l3 gene Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (PubMed:7957253). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (By similarity). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). Indicus|evm.model.CM009512.1.276 A0A1B0GUX0 VAFNB_HUMAN 49.206 0.28972 1.21591 ATP6V1FNB - Protein ATP6V1FNB - Homo sapiens (Human) - ATP6V1FNB gene Indicus|evm.model.CM009512.1.277 Q9MZD2 FLNB_RABIT 97.945 0.112834 8.77211 FLNB - Filamin-B - Oryctolagus cuniculus (Rabbit) - FLNB gene Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity). Indicus|evm.model.CM009512.1.278 Q14BN4 SLMAP_HUMAN 95.503 0.997636 1.02174 SLMAP - Sarcolemmal membrane-associated protein - Homo sapiens (Human) - SLMAP gene May play a role during myoblast fusion. Indicus|evm.model.CM009512.1.279 Q8IWF6 DEN6A_HUMAN 95.888 0.996716 1.00164 DENND6A - Protein DENND6A - Homo sapiens (Human) - DENND6A gene Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes. Indicus|evm.model.CM009512.1.280 Q3SZF2 ARF4_BOVIN 100.000 0.98895 1.00556 ARF4 - ADP-ribosylation factor 4 - Bos taurus (Bovine) - ARF4 gene GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Indicus|evm.model.CM009512.1.281 Q08DF7 PDE12_BOVIN 100.000 0.996721 1.00164 PDE12 - 2',5'-phosphodiesterase 12 precursor - Bos taurus (Bovine) - PDE12 gene Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells. Indicus|evm.model.CM009512.1.282 Q6ZR08 DYH12_HUMAN 94.416 0.198687 1.28105 DNAH12 - Dynein axonemal heavy chain 12 - Homo sapiens (Human) - DNAH12 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Indicus|evm.model.CM009512.1.283 Q58CT0 DYH12_BOVIN 100.000 0.608919 1.63764 DNAH12 - Dynein axonemal heavy chain 12 - Bos taurus (Bovine) - DNAH12 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Indicus|evm.model.CM009512.1.284 Q9UKG1 DP13A_HUMAN 97.743 0.997179 1 APPL1 - DCC-interacting protein 13-alpha - Homo sapiens (Human) - APPL1 gene Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:26073777, PubMed:19661063, PubMed:10490823). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:26073777, PubMed:19661063, PubMed:24879834). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). Indicus|evm.model.CM009512.1.285 Q8NFM7 I17RD_HUMAN 90.000 0.997294 1 IL17RD - Interleukin-17 receptor D precursor - Homo sapiens (Human) - IL17RD gene Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12958313, PubMed:12807873). Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK (PubMed:15239952). Mediates JNK activation and may be involved in apoptosis (By similarity). May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Indicus|evm.model.CM009512.1.286 Q9NR81 ARHG3_HUMAN 96.579 0.896926 1.05133 ARHGEF3 - Rho guanine nucleotide exchange factor 3 - Homo sapiens (Human) - ARHGEF3 gene Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. Indicus|evm.model.CM009512.1.287 Q9UK61 TASOR_HUMAN 88.796 0.945136 1.05868 TASOR - Protein TASOR - Homo sapiens (Human) - TASOR gene Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). Indicus|evm.model.CM009512.1.288 F1PZQ5 CCD66_CANLF 76.495 0.96319 1.0642 CCDC66 - Coiled-coil domain-containing protein 66 - Canis lupus familiaris (Dog) - CCDC66 gene Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (By similarity). Plays a role in retina morphogenesis and/or homeostasis (PubMed:19777273). Indicus|evm.model.CM009512.1.289 O15083 ERC2_HUMAN 98.955 0.997904 0.996865 ERC2 - ERC protein 2 - Homo sapiens (Human) - ERC2 gene Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. Indicus|evm.model.CM009512.1.290 Q27Q52 WNT5A_RABIT 98.421 0.994751 1.00263 WNT5A - Protein Wnt-5a precursor - Oryctolagus cuniculus (Rabbit) - WNT5A gene Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur (PubMed:16754689). Inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells (By similarity). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle (By similarity). Inhibits type II collagen expression in chondrocytes (PubMed:16754689). Indicus|evm.model.CM009512.1.292 Q9Z1L5 CA2D3_MOUSE 90.749 0.585938 0.351971 Cacna2d3 - Voltage-dependent calcium channel subunit alpha-2/delta-3 precursor - Mus musculus (Mouse) - Cacna2d3 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G). Indicus|evm.model.CM009512.1.293 Q9HBL6 LRTM1_HUMAN 76.418 0.994048 0.973913 LRTM1 - Leucine-rich repeat and transmembrane domain-containing protein 1 precursor - Homo sapiens (Human) - LRTM1 gene heparin binding, Roundabout binding, axon guidance, negative chemotaxis Indicus|evm.model.CM009512.1.294 Q8CFG5 CA2D3_RAT 99.052 0.880753 0.440553 Cacna2d3 - Voltage-dependent calcium channel subunit alpha-2/delta-3 precursor - Rattus norvegicus (Rat) - Cacna2d3 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). Indicus|evm.model.CM009512.1.296 Q8IZS8 CA2D3_HUMAN 99.242 0.876667 0.274977 CACNA2D3 - Voltage-dependent calcium channel subunit alpha-2/delta-3 precursor - Homo sapiens (Human) - CACNA2D3 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). Indicus|evm.model.CM009512.1.297 Q8CFG5 CA2D3_RAT 95.122 0.43956 0.083871 Cacna2d3 - Voltage-dependent calcium channel subunit alpha-2/delta-3 precursor - Rattus norvegicus (Rat) - Cacna2d3 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). Indicus|evm.model.CM009512.1.298 Q8IZS8 CA2D3_HUMAN 91.176 0.326829 0.187901 CACNA2D3 - Voltage-dependent calcium channel subunit alpha-2/delta-3 precursor - Homo sapiens (Human) - CACNA2D3 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). Indicus|evm.model.CM009512.1.299 P62630 EF1A1_RAT 97.861 0.989362 0.406926 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009512.1.300 Q1LZF2 ARP8_BOVIN 100.000 0.9968 1.0016 ACTR8 - Actin-related protein 8 - Bos taurus (Bovine) - ACTR8 gene Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity). Indicus|evm.model.CM009512.1.301 Q9NRM6 I17RB_HUMAN 78.208 0.973948 0.994024 IL17RB - Interleukin-17 receptor B precursor - Homo sapiens (Human) - IL17RB gene Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. Indicus|evm.model.CM009512.1.302 Q8NE62 CHDH_HUMAN 81.726 0.717526 0.816498 CHDH - Choline dehydrogenase, mitochondrial precursor - Homo sapiens (Human) - CHDH gene mitochondrial inner membrane, choline dehydrogenase activity, oxidoreductase activity, choline catabolic process Indicus|evm.model.CM009512.1.303 Q99244 CAC1D_MESAU 96.590 0.711567 1.24037 CACNA1D - Voltage-dependent L-type calcium channel subunit alpha-1D - Mesocricetus auratus (Golden hamster) - CACNA1D gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Indicus|evm.model.CM009512.1.304 O41515 MLP3B_BOVIN 65.600 0.975904 0.664 MAP1LC3B - Microtubule-associated proteins 1A/1B light chain 3B precursor - Bos taurus (Bovine) - MAP1LC3B gene Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Indicus|evm.model.CM009512.1.305 I3LHS8 DCP1A_PIG 89.483 0.996422 0.963793 DCP1A - mRNA-decapping enzyme 1A - Sus scrofa (Pig) - DCP1A gene Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Indicus|evm.model.CM009512.1.306 Q6B855 TKT_BOVIN 99.197 0.996795 1.00161 TKT - Transketolase - Bos taurus (Bovine) - TKT gene Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Indicus|evm.model.CM009512.1.307 Q5PU49 KPCD_CANLF 91.407 0.995556 1.00148 PRKCD - Protein kinase C delta type - Canis lupus familiaris (Dog) - PRKCD gene Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (By similarity). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion. Phosphorylates ELAVL1 in response to angiotensin-2 treatment (By similarity). Phosphorylates mitochondrial phospolipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (By similarity). Phosphorylates SMPD1 which induces SMPD1 secretion (By similarity). Indicus|evm.model.CM009512.1.309 Q96AA3 RFT1_HUMAN 90.943 0.99631 1.00185 RFT1 - Protein RFT1 homolog - Homo sapiens (Human) - RFT1 gene May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane. Indicus|evm.model.CM009512.1.310 Q9UHJ3 SMBT1_HUMAN 96.536 0.997691 1 SFMBT1 - Scm-like with four MBT domains protein 1 - Homo sapiens (Human) - SFMBT1 gene Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis. Indicus|evm.model.CM009512.1.311 Q86TL2 STIMA_HUMAN 97.619 0.99322 1.0034 STIMATE - Store-operated calcium entry regulator STIMATE - Homo sapiens (Human) - STIMATE gene Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574). Indicus|evm.model.CM009512.1.312 Q32KU9 MSTN1_BOVIN 96.341 0.931034 1.06098 MUSTN1 - Musculoskeletal embryonic nuclear protein 1 - Bos taurus (Bovine) - MUSTN1 gene May be involved in the development and regeneration of the musculoskeletal system. Indicus|evm.model.CM009512.1.313 Q3T052 ITIH4_BOVIN 99.454 0.997819 1.00109 ITIH4 - Inter-alpha-trypsin inhibitor heavy chain H4 precursor - Bos taurus (Bovine) - ITIH4 gene Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. Indicus|evm.model.CM009512.1.314 P56652 ITIH3_BOVIN 99.776 0.997758 1.00112 ITIH3 - Inter-alpha-trypsin inhibitor heavy chain H3 precursor - Bos taurus (Bovine) - ITIH3 gene May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Indicus|evm.model.CM009512.1.315 Q0VCM5 ITIH1_BOVIN 99.338 0.997795 1.0011 ITIH1 - Inter-alpha-trypsin inhibitor heavy chain H1 precursor - Bos taurus (Bovine) - ITIH1 gene May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Indicus|evm.model.CM009512.1.316 P51957 NEK4_HUMAN 77.106 0.997462 0.93698 NEK4 - Serine/threonine-protein kinase Nek4 - Homo sapiens (Human) - NEK4 gene Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. Indicus|evm.model.CM009512.1.317 Q3T134 SPCS1_BOVIN 100.000 0.265789 3.72549 SPCS1 - Signal peptidase complex subunit 1 - Bos taurus (Bovine) - SPCS1 gene Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Indicus|evm.model.CM009512.1.318 Q5E9E7 GL8D1_BOVIN 100.000 0.994624 1.0027 GLT8D1 - Glycosyltransferase 8 domain-containing protein 1 - Bos taurus (Bovine) - GLT8D1 gene Golgi apparatus Indicus|evm.model.CM009512.1.319 Q9BVP2 GNL3_HUMAN 78.909 0.996337 0.994536 GNL3 - Guanine nucleotide-binding protein-like 3 - Homo sapiens (Human) - GNL3 gene May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). Indicus|evm.model.CM009512.1.320 Q86U86 PB1_HUMAN 98.638 0.998816 1 PBRM1 - Protein polybromo-1 - Homo sapiens (Human) - PBRM1 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. Indicus|evm.model.CM009512.1.321 Q8WVI0 SMIM4_HUMAN 92.754 0.839506 1.15714 SMIM4 - Small integral membrane protein 4 - Homo sapiens (Human) - SMIM4 gene Indicus|evm.model.CM009512.1.322 Q9H857 NT5D2_HUMAN 97.297 0.973631 0.948077 NT5DC2 - 5'-nucleotidase domain-containing protein 2 - Homo sapiens (Human) - NT5DC2 gene 5'-nucleotidase activity Indicus|evm.model.CM009512.1.323 Q9NY15 STAB1_HUMAN 84.215 0.999221 0.999611 STAB1 - Stabilin-1 precursor - Homo sapiens (Human) - STAB1 gene Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. Indicus|evm.model.CM009512.1.324 Q9Y2I1 NISCH_HUMAN 90.749 0.992598 0.988032 NISCH - Nischarin - Homo sapiens (Human) - NISCH gene Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures. Indicus|evm.model.CM009512.1.325 P63317 TNNC1_PIG 100.000 0.987654 1.00621 TNNC1 - Troponin C, slow skeletal and cardiac muscles - Sus scrofa (Pig) - TNNC1 gene Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Indicus|evm.model.CM009512.1.326 Q9NS98 SEM3G_HUMAN 86.154 0.997406 0.985934 SEMA3G - Semaphorin-3G precursor - Homo sapiens (Human) - SEMA3G gene Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity). Indicus|evm.model.CM009512.1.327 Q9BWX1 PHF7_HUMAN 84.856 0.994792 1.00787 PHF7 - PHD finger protein 7 - Homo sapiens (Human) - PHF7 gene May play a role in spermatogenesis. Indicus|evm.model.CM009512.1.328 A2VDM8 BAP1_BOVIN 95.376 0.98984 0.969058 BAP1 - Ubiquitin carboxyl-terminal hydrolase BAP1 - Bos taurus (Bovine) - BAP1 gene Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor. Indicus|evm.model.CM009512.1.329 Q9P2D7 DYH1_HUMAN 91.122 0.612285 0.965768 DNAH1 - Dynein axonemal heavy chain 1 - Homo sapiens (Human) - DNAH1 gene Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805). Indicus|evm.model.CM009512.1.330 Q2KJF7 GLCTK_BOVIN 93.117 0.995902 0.933078 GLYCTK - Glycerate kinase - Bos taurus (Bovine) - GLYCTK gene cytoplasm, glycerate kinase activity, protein phosphorylation Indicus|evm.model.CM009512.1.331 Q8BFQ4 WDR82_MOUSE 99.675 0.962382 1.01917 Wdr82 - WD repeat-containing protein 82 - Mus musculus (Mouse) - Wdr82 gene Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Possible role in telomere length maintenance and in mRNA processing (By similarity). Indicus|evm.model.CM009512.1.332 Q96MI6 PPM1M_HUMAN 92.857 0.587822 1.58148 PPM1M - Protein phosphatase 1M - Homo sapiens (Human) - PPM1M gene nucleus, manganese ion binding, protein serine/threonine phosphatase activity, protein dephosphorylation Indicus|evm.model.CM009512.1.333 Q6IBS0 TWF2_HUMAN 95.129 0.994286 1.00287 TWF2 - Twinfilin-2 - Homo sapiens (Human) - TWF2 gene Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). Indicus|evm.model.CM009512.1.334 Q5I2M5 TLR9_BOVIN 99.604 0.821806 1.19436 TLR9 - Toll-like receptor 9 precursor - Bos taurus (Bovine) - TLR9 gene Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). Indicus|evm.model.CM009512.1.335 A6QLI6 HEM1_BOVIN 100.000 0.920228 1.08501 ALAS1 - 5-aminolevulinate synthase, nonspecific, mitochondrial precursor - Bos taurus (Bovine) - ALAS1 gene mitochondrion, 5-aminolevulinate synthase activity, erythrocyte development, heme biosynthetic process, hemoglobin biosynthetic process, response to hypoxia Indicus|evm.model.CM009512.1.336 Q2TBP4 POC1A_BOVIN 100.000 0.995098 1.00246 POC1A - POC1 centriolar protein homolog A - Bos taurus (Bovine) - POC1A gene Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity). Indicus|evm.model.CM009512.1.337 Q63340 DUS7_RAT 99.728 0.99458 0.880668 Dusp7 - Dual specificity protein phosphatase 7 - Rattus norvegicus (Rat) - Dusp7 gene Dual specificity protein phosphatase (By similarity). Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex. Indicus|evm.model.CM009512.1.338 Q58DW3 RL29_BOVIN 100.000 0.986928 1.00658 RPL29 - 60S ribosomal protein L29 - Bos taurus (Bovine) - RPL29 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009512.1.339 P37111 ACY1_PIG 88.971 0.99511 1.00491 ACY1 - Aminoacylase-1 - Sus scrofa (Pig) - ACY1 gene Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). Indicus|evm.model.CM009512.1.340 Q9BUJ0 ABHEA_HUMAN 85.597 0.987755 0.904059 ABHD14A - Protein ABHD14A - Homo sapiens (Human) - ABHD14A gene Possible role in granule neuron development. Indicus|evm.model.CM009512.1.341 A7YY28 ABHEB_BOVIN 100.000 0.990521 1.00476 ABHD14B - Protein ABHD14B - Bos taurus (Bovine) - ABHD14B gene Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription (By similarity). Indicus|evm.model.CM009512.1.342 Q0VCU0 PCBP4_BOVIN 100.000 0.99505 1.00248 PCBP4 - Poly(rC)-binding protein 4 - Bos taurus (Bovine) - PCBP4 gene Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Indicus|evm.model.CM009512.1.343 Q9BZJ7 GPR62_HUMAN 83.951 0.71875 0.608696 GPR62 - G-protein coupled receptor 62 - Homo sapiens (Human) - GPR62 gene Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). Indicus|evm.model.CM009512.1.344 Q9Y6F1 PARP3_HUMAN 70.182 0.945255 1.02814 PARP3 - Protein mono-ADP-ribosyltransferase PARP3 - Homo sapiens (Human) - PARP3 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:16924674, PubMed:20064938, PubMed:21211721, PubMed:21270334, PubMed:25043379, PubMed:24598253). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (PubMed:20064938, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ (PubMed:24598253). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6 (PubMed:16924674, PubMed:24598253). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (PubMed:16924674). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (PubMed:29361132, PubMed:29520010). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity). Indicus|evm.model.CM009512.1.345 O43818 U3IP2_HUMAN 93.263 0.995798 1.00211 RRP9 - U3 small nucleolar RNA-interacting protein 2 - Homo sapiens (Human) - RRP9 gene Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Indicus|evm.model.CM009512.1.346 Q3SYS7 IQCF1_BOVIN 100.000 0.990476 1.00478 IQCF1 - IQ domain-containing protein F1 - Bos taurus (Bovine) - IQCF1 gene Involved in sperm capacitation and acrosome reaction. Indicus|evm.model.CM009512.1.347 Q32KU4 IQCF5_BOVIN 100.000 0.88024 1.12081 IQCF5 - IQ domain-containing protein F5 - Bos taurus (Bovine) - IQCF5 gene calmodulin binding Indicus|evm.model.CM009512.1.348 Q2M2U5 IQCF2_BOVIN 99.387 0.987805 1.00613 IQCF2 - IQ domain-containing protein F2 - Bos taurus (Bovine) - IQCF2 gene calmodulin binding Indicus|evm.model.CM009512.1.349 P0C7M6 IQCF3_HUMAN 59.494 0.817708 1.24675 IQCF3 - IQ domain-containing protein F3 - Homo sapiens (Human) - IQCF3 gene calmodulin binding Indicus|evm.model.CM009512.1.350 Q32KU4 IQCF5_BOVIN 66.667 0.732323 1.32886 IQCF5 - IQ domain-containing protein F5 - Bos taurus (Bovine) - IQCF5 gene calmodulin binding Indicus|evm.model.CM009512.1.351 A8MYZ5 IQCF6_HUMAN 98.131 0.981481 1.00935 IQCF6 - IQ domain-containing protein F6 - Homo sapiens (Human) - IQCF6 gene calmodulin binding Indicus|evm.model.CM009512.1.353 Q148C9 HEBP1_BOVIN 97.382 0.989583 1.00524 HEBP1 - Heme-binding protein 1 - Bos taurus (Bovine) - HEBP1 gene May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity). Indicus|evm.model.CM009512.1.354 Q14416 GRM2_HUMAN 98.624 0.997709 1.00115 GRM2 - Metabotropic glutamate receptor 2 precursor - Homo sapiens (Human) - GRM2 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Indicus|evm.model.CM009512.1.355 Q9Y6I9 TX264_HUMAN 86.598 0.923567 1.00319 TEX264 - Testis-expressed protein 264 - Homo sapiens (Human) - TEX264 gene Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270). Indicus|evm.model.CM009512.1.356 Q9Y4B4 ARIP4_HUMAN 92.643 0.998596 0.970688 RAD54L2 - Helicase ARIP4 - Homo sapiens (Human) - RAD54L2 gene DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). Indicus|evm.model.CM009512.1.357 Q9Y4B6 DCAF1_HUMAN 98.275 0.998674 1.00066 DCAF1 - DDB1- and CUL4-associated factor 1 - Homo sapiens (Human) - DCAF1 gene Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). Indicus|evm.model.CM009512.1.358 Q8NDT2 RB15B_HUMAN 94.397 0.947917 0.970787 RBM15B - Putative RNA-binding protein 15B - Homo sapiens (Human) - RBM15B gene RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). Indicus|evm.model.CM009512.1.359 P80513 MANF_BOVIN 100.000 0.988889 1.00559 MANF - Mesencephalic astrocyte-derived neurotrophic factor precursor - Bos taurus (Bovine) - MANF gene Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions. Indicus|evm.model.CM009512.1.360 Q8IZD9 DOCK3_HUMAN 96.505 0.991334 1.02315 DOCK3 - Dedicator of cytokinesis protein 3 - Homo sapiens (Human) - DOCK3 gene Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity). Indicus|evm.model.CM009512.1.361 Q3SYZ2 MAPK3_BOVIN 100.000 0.994805 1.0026 MAPKAPK3 - MAP kinase-activated protein kinase 3 - Bos taurus (Bovine) - MAPKAPK3 gene Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression (By similarity). Indicus|evm.model.CM009512.1.362 Q2HJ53 CISH_BOVIN 100.000 0.992157 1.00394 CISH - Cytokine-inducible SH2-containing protein - Bos taurus (Bovine) - CISH gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Indicus|evm.model.CM009512.1.363 Q9Y5R4 HEMK1_HUMAN 81.677 0.818414 1.1568 HEMK1 - MTRF1L release factor glutamine methyltransferase - Homo sapiens (Human) - HEMK1 gene N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L. Indicus|evm.model.CM009512.1.364 Q9UK00 CC018_HUMAN 91.975 0.98773 1.00617 C3orf18 - Uncharacterized protein C3orf18 - Homo sapiens (Human) - C3orf18 gene Indicus|evm.model.CM009512.1.365 Q6PHS9 CA2D2_MOUSE 94.816 0.935194 0.962738 Cacna2d2 - Voltage-dependent calcium channel subunit alpha-2/delta-2 precursor - Mus musculus (Mouse) - Cacna2d2 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Indicus|evm.model.CM009512.1.366 A4FUB8 TM115_BOVIN 100.000 0.994318 1.00285 TMEM115 - Transmembrane protein 115 - Bos taurus (Bovine) - TMEM115 gene May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. Indicus|evm.model.CM009512.1.367 Q5E965 C56D2_BOVIN 100.000 0.991031 1.0045 CYB561D2 - Transmembrane reductase CYB561D2 - Bos taurus (Bovine) - CYB561D2 gene Transmembrane reductase that may use ascorbate as an electron donor in the cytoplasm and transfer electrons across endoplasmic reticulum membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in the lumen of that compartment. Indicus|evm.model.CM009512.1.368 Q5E9U9 NPRL2_BOVIN 100.000 0.994751 1.00263 NPRL2 - GATOR complex protein NPRL2 - Bos taurus (Bovine) - NPRL2 gene As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. Indicus|evm.model.CM009512.1.369 O75800 ZMY10_HUMAN 93.182 0.995455 1 ZMYND10 - Zinc finger MYND domain-containing protein 10 - Homo sapiens (Human) - ZMYND10 gene Plays a role in axonemal structure organization and motility (PubMed:23891469, PubMed:23891471). Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity). Indicus|evm.model.CM009512.1.370 Q9NS23 RASF1_HUMAN 93.314 0.994135 0.991279 RASSF1 - Ras association domain-containing protein 1 - Homo sapiens (Human) - RASSF1 gene Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. Indicus|evm.model.CM009512.1.371 O75896 TUSC2_HUMAN 94.545 0.981982 1.00909 TUSC2 - Tumor suppressor candidate 2 - Homo sapiens (Human) - TUSC2 gene May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells. Indicus|evm.model.CM009512.1.372 Q8SQG8 HYAL2_BOVIN 100.000 0.995781 1.00211 HYAL2 - Hyaluronidase-2 precursor - Bos taurus (Bovine) - HYAL2 gene Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity). Indicus|evm.model.CM009512.1.373 Q5E985 HYAL1_BOVIN 99.563 0.609626 0.831111 HYAL1 - Hyaluronidase-1 precursor - Bos taurus (Bovine) - HYAL1 gene May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Indicus|evm.model.CM009512.1.374 Q12894 IFRD2_HUMAN 87.330 0.995465 0.871542 IFRD2 - Interferon-related developmental regulator 2 - Homo sapiens (Human) - IFRD2 gene nucleus Indicus|evm.model.CM009512.1.375 Q8N112 LSME2_HUMAN 77.778 0.781915 1.14634 LSMEM2 - Leucine-rich single-pass membrane protein 2 - Homo sapiens (Human) - LSMEM2 gene Indicus|evm.model.CM009512.1.376 Q13214 SEM3B_HUMAN 89.867 0.997333 1.00134 SEMA3B - Semaphorin-3B precursor - Homo sapiens (Human) - SEMA3B gene Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Indicus|evm.model.CM009512.1.378 P04899 GNAI2_HUMAN 99.437 0.994382 1.00282 GNAI2 - Guanine nucleotide-binding protein G(i) subunit alpha-2 - Homo sapiens (Human) - GNAI2 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Indicus|evm.model.CM009512.1.379 Q99624 S38A3_HUMAN 89.881 0.99604 1.00198 SLC38A3 - Sodium-coupled neutral amino acid transporter 3 - Homo sapiens (Human) - SLC38A3 gene Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission. Indicus|evm.model.CM009512.1.380 P04695 GNAT1_BOVIN 100.000 0.938172 1.06286 GNAT1 - Guanine nucleotide-binding protein G(t) subunit alpha-1 - Bos taurus (Bovine) - GNAT1 gene Functions as signal transducer for the rod photoreceptor RHO (PubMed:21285355, PubMed:23303210, PubMed:28655769, PubMed:8259210). Required for normal RHO-mediated light perception by the retina (By similarity). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:21285355, PubMed:28655769, PubMed:8259210, PubMed:8208289, PubMed:7969474). Activated RHO promotes GDP release and GTP binding (PubMed:21285355, PubMed:28655769). Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (PubMed:21285355). Indicus|evm.model.CM009512.1.381 Q13275 SEM3F_HUMAN 92.298 0.997478 1.01019 SEMA3F - Semaphorin-3F precursor - Homo sapiens (Human) - SEMA3F gene May play a role in cell motility and cell adhesion. Indicus|evm.model.CM009512.1.382 Q1RMU5 RBM5_BOVIN 100.000 0.997549 1.00123 RBM5 - RNA-binding protein 5 - Bos taurus (Bovine) - RBM5 gene Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity). Indicus|evm.model.CM009512.1.383 P78332 RBM6_HUMAN 90.917 0.998216 0.998219 RBM6 - RNA-binding protein 6 - Homo sapiens (Human) - RBM6 gene Specifically binds poly(G) RNA homopolymers in vitro. Indicus|evm.model.CM009512.1.384 Q17QV2 MON1A_BOVIN 100.000 0.996403 1.0018 MON1A - Vacuolar fusion protein MON1 homolog A - Bos taurus (Bovine) - MON1A gene Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Indicus|evm.model.CM009512.1.385 Q04912 RON_HUMAN 80.866 0.982882 1.00143 MST1R - Macrophage-stimulating protein receptor precursor - Homo sapiens (Human) - MST1R gene Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. Indicus|evm.model.CM009512.1.386 Q4QR76 ACL7B_RAT 42.507 0.287967 2.88969 Actl7b - Actin-like protein 7B - Rattus norvegicus (Rat) - Actl7b gene cytoplasm, dynactin complex, nucleus Indicus|evm.model.CM009512.1.387 Q8NCB2 CAMKV_HUMAN 93.254 0.99604 1.00798 CAMKV - CaM kinase-like vesicle-associated protein - Homo sapiens (Human) - CAMKV gene Does not appear to have detectable kinase activity. Indicus|evm.model.CM009512.1.388 Q9BWF2 TRAIP_HUMAN 81.953 0.993658 1.00853 TRAIP - E3 ubiquitin-protein ligase TRAIP - Homo sapiens (Human) - TRAIP gene E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26781088, PubMed:27462463, PubMed:26711499, PubMed:26595769, PubMed:31545170). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is however controversial (PubMed:26595769). Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920). Indicus|evm.model.CM009512.1.389 P41226 UBA7_HUMAN 75.988 0.997998 0.987154 UBA7 - Ubiquitin-like modifier-activating enzyme 7 - Homo sapiens (Human) - UBA7 gene Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein. Indicus|evm.model.CM009512.1.390 Q96EL1 INKA1_HUMAN 82.168 0.992958 0.989547 INKA1 - PAK4-inhibitor INKA1 - Homo sapiens (Human) - INKA1 gene Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847). Indicus|evm.model.CM009512.1.391 A6H8M9 CDHR4_HUMAN 74.380 0.920716 0.992386 CDHR4 - Cadherin-related family member 4 precursor - Homo sapiens (Human) - CDHR4 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). Indicus|evm.model.CM009512.1.392 Q92551 IP6K1_HUMAN 96.145 0.995475 1.00227 IP6K1 - Inositol hexakisphosphate kinase 1 - Homo sapiens (Human) - IP6K1 gene Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Indicus|evm.model.CM009512.1.393 Q2YDJ9 GMPPB_BOVIN 98.611 0.99446 1.00278 GMPPB - Mannose-1-phosphate guanyltransferase beta - Bos taurus (Bovine) - GMPPB gene Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. Indicus|evm.model.CM009512.1.394 Q5XPI3 RN123_MOUSE 91.918 0.998488 1.00685 Rnf123 - E3 ubiquitin-protein ligase RNF123 - Mus musculus (Mouse) - Rnf123 gene Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS. Indicus|evm.model.CM009512.1.395 Q24K22 HGFL_BOVIN 94.250 0.977961 1.01966 MST1 - Hepatocyte growth factor-like protein precursor - Bos taurus (Bovine) - MST1 gene extracellular space, receptor tyrosine kinase binding, serine-type endopeptidase activity, negative regulation of gluconeogenesis, positive regulation of mammary gland epithelial cell proliferation, regulation of cAMP-dependent protein kinase activity, regulation of macrophage chemotaxis Indicus|evm.model.CM009512.1.396 P80227 ACPH_BOVIN 100.000 0.997264 1.00137 APEH - Acylamino-acid-releasing enzyme - Bos taurus (Bovine) - APEH gene This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. Indicus|evm.model.CM009512.1.398 Q9UPA5 BSN_HUMAN 87.431 0.799164 0.914417 BSN - Protein bassoon - Homo sapiens (Human) - BSN gene Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Indicus|evm.model.CM009512.1.399 O18738 DAG1_BOVIN 99.106 0.997768 1.00112 DAG1 - Dystroglycan precursor - Bos taurus (Bovine) - DAG1 gene The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Indicus|evm.model.CM009512.1.400 Q5EAA5 TCTA_BOVIN 100.000 0.981308 1.00943 TCTA - T-cell leukemia translocation-altered gene protein homolog - Bos taurus (Bovine) - TCTA gene May be required for cellular fusion during osteoclastogenesis. Indicus|evm.model.CM009512.1.401 P25285 GCST_BOVIN 100.000 0.980198 1.01763 AMT - Aminomethyltransferase, mitochondrial precursor - Bos taurus (Bovine) - AMT gene The glycine cleavage system catalyzes the degradation of glycine. Indicus|evm.model.CM009512.1.402 Q861Y6 NICN1_CANLF 97.183 0.990654 1.00469 NICN1 - Nicolin-1 - Canis lupus familiaris (Dog) - NICN1 gene nucleoplasm Indicus|evm.model.CM009512.1.403 Q5REY6 RHOA_PONAB 100.000 0.989691 1.00518 RHOA - Transforming protein RhoA precursor - Pongo abelii (Sumatran orangutan) - RHOA gene Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis. Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center. May be an activator of PLCE1. In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). Indicus|evm.model.CM009512.1.404 P00435 GPX1_BOVIN 100.000 0.485437 0.502439 GPX1 - Glutathione peroxidase 1 - Bos taurus (Bovine) - GPX1 gene Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism. Indicus|evm.model.CM009512.1.405 P00435 GPX1_BOVIN 100.000 0.986207 0.707317 GPX1 - Glutathione peroxidase 1 - Bos taurus (Bovine) - GPX1 gene Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism. Indicus|evm.model.CM009512.1.406 A6QR55 UBP4_BOVIN 100.000 0.997925 1.00104 USP4 - Ubiquitin carboxyl-terminal hydrolase 4 - Bos taurus (Bovine) - USP4 gene Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER. Indicus|evm.model.CM009512.1.407 Q6ZUJ4 CC062_HUMAN 80.827 0.89527 1.10861 C3orf62 - Uncharacterized protein C3orf62 - Homo sapiens (Human) - C3orf62 gene Indicus|evm.model.CM009512.1.408 Q8IYA8 IHO1_HUMAN 67.384 0.996656 1.00673 IHO1 - Interactor of HORMAD1 protein 1 - Homo sapiens (Human) - IHO1 gene Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. Indicus|evm.model.CM009512.1.409 H3BNL1 CC084_HUMAN 80.296 0.984848 0.970588 C3orf84 - Uncharacterized protein C3orf84 - Homo sapiens (Human) - C3orf84 gene Indicus|evm.model.CM009512.1.410 Q5E9V5 KLD8B_BOVIN 99.718 0.994366 1.00282 KLHDC8B - Kelch domain-containing protein 8B - Bos taurus (Bovine) - KLHDC8B gene Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. Indicus|evm.model.CM009512.1.411 Q2HJ91 CCD71_BOVIN 99.779 0.995585 1.00221 CCDC71 - Coiled-coil domain-containing protein 71 - Bos taurus (Bovine) - CCDC71 gene Indicus|evm.model.CM009512.1.412 O94966 UBP19_HUMAN 93.768 0.21209 3.72762 USP19 - Ubiquitin carboxyl-terminal hydrolase 19 - Homo sapiens (Human) - USP19 gene Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. Indicus|evm.model.CM009512.1.413 Q3MHH4 SYQ_BOVIN 95.484 0.997301 0.956129 QARS1 - Glutamine--tRNA ligase - Bos taurus (Bovine) - QARS1 gene Glutamine--tRNA ligase. Plays a critical role in brain development. Indicus|evm.model.CM009512.1.414 Q0P5J0 QRIC1_BOVIN 100.000 0.997436 1.00128 QRICH1 - Transcriptional regulator QRICH1 - Bos taurus (Bovine) - QRICH1 gene Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress. Controls the outcome of the unfolded protein response (UPR), an ER-stress response pathway that either promotes recovery of ER homeostasis and cell survival, or triggers the terminal UPR which elicits programmed cell death when ER stress is prolonged and unresolved. ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR. May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability. Upregulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver. Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth. Indicus|evm.model.CM009512.1.415 Q3SWY3 IMDH2_BOVIN 100.000 0.996117 1.00195 IMPDH2 - Inosine-5'-monophosphate dehydrogenase 2 - Bos taurus (Bovine) - IMPDH2 gene Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Indicus|evm.model.CM009512.1.416 Q2HJI2 NDUF3_BOVIN 100.000 0.989189 1.00543 NDUFAF3 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 - Bos taurus (Bovine) - NDUFAF3 gene Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Indicus|evm.model.CM009512.1.418 Q5D0E6 DALD3_HUMAN 77.449 0.994465 0.998158 DALRD3 - DALR anticodon-binding domain-containing protein 3 - Homo sapiens (Human) - DALRD3 gene Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2A and METTL2B. Indicus|evm.model.CM009512.1.419 A7Z052 WDR6_BOVIN 99.822 0.950085 1.0516 WDR6 - WD repeat-containing protein 6 - Bos taurus (Bovine) - WDR6 gene Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy. Indicus|evm.model.CM009512.1.420 Q9NXG6 P4HTM_HUMAN 91.434 0.99596 0.986056 P4HTM - Transmembrane prolyl 4-hydroxylase - Homo sapiens (Human) - P4HTM gene Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Indicus|evm.model.CM009512.1.421 O95376 ARI2_HUMAN 98.174 0.995935 0.997972 ARIH2 - E3 ubiquitin-protein ligase ARIH2 - Homo sapiens (Human) - ARIH2 gene E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). Indicus|evm.model.CM009512.1.422 O43772 MCAT_HUMAN 83.056 0.992565 0.893688 SLC25A20 - Mitochondrial carnitine/acylcarnitine carrier protein - Homo sapiens (Human) - SLC25A20 gene Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Indicus|evm.model.CM009512.1.423 P00515 KAP2_BOVIN 99.751 0.995025 1.00249 PRKAR2A - cAMP-dependent protein kinase type II-alpha regulatory subunit - Bos taurus (Bovine) - PRKAR2A gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase (By similarity). Indicus|evm.model.CM009512.1.424 Q9UHH9 IP6K2_HUMAN 95.305 0.876033 1.13615 IP6K2 - Inositol hexakisphosphate kinase 2 - Homo sapiens (Human) - IP6K2 gene Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Indicus|evm.model.CM009512.1.425 Q9NZQ3 SPN90_HUMAN 90.234 0.997226 0.998615 NCKIPSD - NCK-interacting protein with SH3 domain - Homo sapiens (Human) - NCKIPSD gene Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. Indicus|evm.model.CM009512.1.426 Q9NYQ7 CELR3_HUMAN 92.827 0.999397 1.00151 CELSR3 - Cadherin EGF LAG seven-pass G-type receptor 3 precursor - Homo sapiens (Human) - CELSR3 gene Receptor that may have an important role in cell/cell signaling during nervous system formation. Indicus|evm.model.CM009512.1.427 Q9BXS9 S26A6_HUMAN 78.824 0.997382 1.00659 SLC26A6 - Solute carrier family 26 member 6 - Homo sapiens (Human) - SLC26A6 gene Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH. Indicus|evm.model.CM009512.1.428 A2RUT3 TMM89_HUMAN 64.151 0.692982 1.43396 TMEM89 - Transmembrane protein 89 precursor - Homo sapiens (Human) - TMEM89 gene nucleus Indicus|evm.model.CM009512.1.429 P31800 QCR1_BOVIN 99.792 0.995842 1.00208 UQCRC1 - Cytochrome b-c1 complex subunit 1, mitochondrial precursor - Bos taurus (Bovine) - UQCRC1 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (PubMed:9694818, PubMed:11073949). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Indicus|evm.model.CM009512.1.430 Q02388 CO7A1_HUMAN 87.020 0.998976 0.995584 COL7A1 - Collagen alpha-1(VII) chain precursor - Homo sapiens (Human) - COL7A1 gene Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. Indicus|evm.model.CM009512.1.431 Q4R8B6 F264_MACFA 98.294 0.995745 1.00213 PFKFB4 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 - Macaca fascicularis (Crab-eating macaque) - PFKFB4 gene Synthesis and degradation of fructose 2,6-bisphosphate. Indicus|evm.model.CM009512.1.432 Q3T0A9 SHSA5_BOVIN 91.667 0.99 0.925926 SHISA5 - Protein shisa-5 precursor - Bos taurus (Bovine) - SHISA5 gene Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. Indicus|evm.model.CM009512.1.433 Q9BG99 TREX1_BOVIN 99.683 0.993671 1.00317 TREX1 - Three-prime repair exonuclease 1 - Bos taurus (Bovine) - TREX1 gene Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity). Indicus|evm.model.CM009512.1.434 Q9N077 ATRIP_MACFA 81.942 0.83038 1.20611 ATRIP - ATR-interacting protein - Macaca fascicularis (Crab-eating macaque) - ATRIP gene Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein (By similarity). Indicus|evm.model.CM009512.1.435 Q8K003 TMA7_MOUSE 100.000 0.969231 1.01562 Tma7 - Translation machinery-associated protein 7 - Mus musculus (Mouse) - Tma7 gene cytoplasmic translation Indicus|evm.model.CM009512.1.436 O43157 PLXB1_HUMAN 89.808 0.840488 1.18923 PLXNB1 - Plexin-B1 precursor - Homo sapiens (Human) - PLXNB1 gene Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496). Indicus|evm.model.CM009512.1.438 P08548 LIN1_NYCCO 59.524 0.251534 0.129365 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Indicus|evm.model.CM009512.1.439 O75414 NDK6_HUMAN 94.624 0.989305 1.00538 NME6 - Nucleoside diphosphate kinase 6 - Homo sapiens (Human) - NME6 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis. Indicus|evm.model.CM009512.1.440 P56425 CTHL7_BOVIN 100.000 0.987952 1.00606 CATHL7 - Cathelicidin-7 precursor - Bos taurus (Bovine) - CATHL7 gene Exerts a potent antimicrobial activity. Indicus|evm.model.CM009512.1.441 P22226 CTHL1_BOVIN 99.355 0.987179 1.00645 CATHL1 - Cathelicidin-1 precursor - Bos taurus (Bovine) - CATHL1 gene Potent microbicidal activity; active against S.aureus and E.coli. Indicus|evm.model.CM009512.1.442 P56425 CTHL7_BOVIN 67.347 0.196507 1.38788 CATHL7 - Cathelicidin-7 precursor - Bos taurus (Bovine) - CATHL7 gene Exerts a potent antimicrobial activity. Indicus|evm.model.CM009512.1.443 P19661 CTHL3_BOVIN 100.000 0.988701 0.931579 CATHL3 - Cathelicidin-3 precursor - Bos taurus (Bovine) - CATHL3 gene Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms. Indicus|evm.model.CM009512.1.444 P19660 CTHL2_BOVIN 99.432 0.988701 1.00568 CATHL2 - Cathelicidin-2 precursor - Bos taurus (Bovine) - CATHL2 gene Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms. Indicus|evm.model.CM009512.1.445 P19661 CTHL3_BOVIN 77.869 0.975806 0.652632 CATHL3 - Cathelicidin-3 precursor - Bos taurus (Bovine) - CATHL3 gene Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms. Indicus|evm.model.CM009512.1.446 P54228 CTHL6_BOVIN 100.000 0.987421 1.00633 CATHL6 - Cathelicidin-6 precursor - Bos taurus (Bovine) - CATHL6 gene Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. Indicus|evm.model.CM009512.1.447 P54229 CTHL5_BOVIN 100.000 0.9875 1.00629 CATHL5 - Cathelicidin-5 precursor - Bos taurus (Bovine) - CATHL5 gene Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. Indicus|evm.model.CM009512.1.448 A7MBD1 MPIP1_BOVIN 100.000 0.996198 1.0019 CDC25A - M-phase inducer phosphatase 1 - Bos taurus (Bovine) - CDC25A gene Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro (By similarity). Indicus|evm.model.CM009512.1.449 P36225 MAP4_BOVIN 93.989 0.921783 1.10914 MAP4 - Microtubule-associated protein 4 - Bos taurus (Bovine) - MAP4 gene Non-neuronal microtubule-associated protein. Promotes microtubule assembly. Indicus|evm.model.CM009512.1.450 Q2NKY8 DHX30_BOVIN 98.886 0.891622 1.06639 DHX30 - ATP-dependent RNA helicase DHX30 - Bos taurus (Bovine) - DHX30 gene RNA dependent helicase. Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1. Associates with mitochondrial DNA. Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD. Indicus|evm.model.CM009512.1.451 Q92922 SMRC1_HUMAN 97.164 0.627309 1.37195 SMARCC1 - SWI/SNF complex subunit SMARCC1 - Homo sapiens (Human) - SMARCC1 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Indicus|evm.model.CM009512.1.452 Q0PNE2 ELP6_HUMAN 84.211 0.81362 1.04887 ELP6 - Elongator complex protein 6 - Homo sapiens (Human) - ELP6 gene Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:22854966). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity). Indicus|evm.model.CM009512.1.453 A6QM06 SCAP_BOVIN 99.765 0.998436 1.00078 SCAP - Sterol regulatory element-binding protein cleavage-activating protein - Bos taurus (Bovine) - SCAP gene Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain. Indicus|evm.model.CM009512.1.454 Q9H3S7 PTN23_HUMAN 88.347 0.998738 0.968826 PTPN23 - Tyrosine-protein phosphatase non-receptor type 23 - Homo sapiens (Human) - PTPN23 gene Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). Indicus|evm.model.CM009512.1.455 P26202 P15A_RABIT 54.762 0.716763 1.26277 15 kDa protein A precursor - Oryctolagus cuniculus (Rabbit) Indicus|evm.model.CM009512.1.456 E9Q4F2 KLH18_MOUSE 97.387 0.996522 1.00174 Klhl18 - Kelch-like protein 18 - Mus musculus (Mouse) - Klhl18 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis (By similarity). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). Regulates light- and dark-dependent alpha-transducin localization changes in rod photoreceptors through UNC119 ubiquitination and degradation (PubMed:31696965). Preferentially ubiquitinates the unphosphorylated form of UNC119 over the phosphorylated form (PubMed:31696965). In the presence of UNC119, under dark-adapted conditions alpha-transducin mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light (PubMed:31696965). Indicus|evm.model.CM009512.1.457 Q9HAQ2 KIF9_HUMAN 91.013 0.921637 1.08228 KIF9 - Kinesin-like protein KIF9 - Homo sapiens (Human) - KIF9 gene kinesin complex, microtubule, podosome, vesicle, ATPase activity, identical protein binding, microtubule binding, microtubule motor activity, extracellular matrix disassembly, microtubule-based movement Indicus|evm.model.CM009512.1.458 Q9BYW2 SETD2_HUMAN 89.567 0.964571 1.02379 SETD2 - Histone-lysine N-methyltransferase SETD2 - Homo sapiens (Human) - SETD2 gene Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). Indicus|evm.model.CM009512.1.459 Q8K5A9 NRADD_RAT 74.459 0.991304 1.00877 Nradd - Death domain-containing membrane protein NRADD - Rattus norvegicus (Rat) - Nradd gene Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR (By similarity). Both isoform 1 and isoform 2 promote apoptosis. Indicus|evm.model.CM009512.1.460 Q6ZNJ1 NBEL2_HUMAN 88.214 0.998874 0.96732 NBEAL2 - Neurobeachin-like protein 2 - Homo sapiens (Human) - NBEAL2 gene Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. Indicus|evm.model.CM009512.1.461 Q8WUD4 CCD12_HUMAN 90.476 0.988166 1.01807 CCDC12 - Coiled-coil domain-containing protein 12 - Homo sapiens (Human) - CCDC12 gene post-mRNA release spliceosomal complex, U2-type spliceosomal complex Indicus|evm.model.CM009512.1.462 Q1LZF7 PTH1R_BOVIN 99.830 0.99661 1.0017 PTH1R - Parathyroid hormone/parathyroid hormone-related peptide receptor precursor - Bos taurus (Bovine) - PTH1R gene Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009512.1.463 P85100 MYL3_BOVIN 100.000 0.99 1.00503 MYL3 - Myosin light chain 3 - Bos taurus (Bovine) - MYL3 gene Regulatory light chain of myosin. Does not bind calcium. Indicus|evm.model.CM009512.1.464 Q7Z5A4 PRS42_HUMAN 55.102 0.852507 1.157 PRSS42P - Putative serine protease 42 precursor - Homo sapiens (Human) - PRSS42P gene Plays a role in spermatogenesis. Involved in germ cell survival during meiosis. Indicus|evm.model.CM009512.1.465 Q402U7 PRS44_MOUSE 55.280 0.668058 1.28763 Prss44 - Serine protease 44 precursor - Mus musculus (Mouse) - Prss44 gene cytoplasm, extracellular space, serine-type endopeptidase activity, germ cell development, proteolysis, spermatogenesis Indicus|evm.model.CM009512.1.466 Q402U7 PRS44_MOUSE 51.613 0.836858 0.889785 Prss44 - Serine protease 44 precursor - Mus musculus (Mouse) - Prss44 gene cytoplasm, extracellular space, serine-type endopeptidase activity, germ cell development, proteolysis, spermatogenesis Indicus|evm.model.CM009512.1.467 Q7Z5A4 PRS42_HUMAN 74.419 0.451613 0.317406 PRSS42P - Putative serine protease 42 precursor - Homo sapiens (Human) - PRSS42P gene Plays a role in spermatogenesis. Involved in germ cell survival during meiosis. Indicus|evm.model.CM009512.1.468 A2VE36 PRS45_BOVIN 99.684 0.993691 1.00316 PRSS45 - Serine protease 45 precursor - Bos taurus (Bovine) - PRSS45 gene extracellular space, serine-type endopeptidase activity, proteolysis Indicus|evm.model.CM009512.1.469 E5RG02 PRS46_HUMAN 69.643 0.532051 1.7931 PRSS46P - Putative serine protease 46 - Homo sapiens (Human) - PRSS46P gene extracellular space, serine-type endopeptidase activity, proteolysis Indicus|evm.model.CM009512.1.470 Q9UI38 TSP50_HUMAN 61.930 0.953368 1.0026 PRSS50 - Probable threonine protease PRSS50 precursor - Homo sapiens (Human) - PRSS50 gene May be involved in proteolysis through its threonine endopeptidase activity. Indicus|evm.model.CM009512.1.471 Q8K467 TMIE_MOUSE 94.531 0.962121 0.862745 Tmie - Transmembrane inner ear expressed protein precursor - Mus musculus (Mouse) - Tmie gene Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain. Indicus|evm.model.CM009512.1.472 A6QP75 AL2CL_BOVIN 99.370 0.996855 1.00105 ALS2CL - ALS2 C-terminal-like protein - Bos taurus (Bovine) - ALS2CL gene Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics (By similarity). Indicus|evm.model.CM009512.1.473 A0A1B0GVK7 F240A_HUMAN 87.013 0.926829 1.06494 FAM240A - Protein FAM240A - Homo sapiens (Human) - FAM240A gene Indicus|evm.model.CM009512.1.474 Q9BYS8 LRRC2_HUMAN 87.360 0.994398 0.962264 LRRC2 - Leucine-rich repeat-containing protein 2 - Homo sapiens (Human) - LRRC2 gene cytoplasm, intracellular membrane-bounded organelle, protein serine/threonine phosphatase activity, signal transduction Indicus|evm.model.CM009512.1.475 Q9BQQ7 RTP3_HUMAN 72.393 0.7 0.991379 RTP3 - Receptor-transporting protein 3 - Homo sapiens (Human) - RTP3 gene Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43. Indicus|evm.model.CM009512.1.476 P24627 TRFL_BOVIN 99.139 0.883249 1.11299 LTF - Lactotransferrin precursor - Bos taurus (Bovine) - LTF gene Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Indicus|evm.model.CM009512.1.477 Q0II78 CCRL2_BOVIN 99.713 0.994269 1.00287 CCRL2 - Chemokine C-C motif receptor-like 2 - Bos taurus (Bovine) - CCRL2 gene Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity). Indicus|evm.model.CM009512.1.478 Q2HJ17 CCR5_BOVIN 99.716 0.994334 1.00284 CCR5 - C-C chemokine receptor type 5 - Bos taurus (Bovine) - CCR5 gene Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. Indicus|evm.model.CM009512.1.479 Q2HJ17 CCR5_BOVIN 80.000 0.916442 1.05398 CCR5 - C-C chemokine receptor type 5 - Bos taurus (Bovine) - CCR5 gene Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. Indicus|evm.model.CM009512.1.481 Q64H34 CCR3_CANLF 79.609 0.991643 1 CCR3 - C-C chemokine receptor type 3 - Canis lupus familiaris (Dog) - CCR3 gene Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. Indicus|evm.model.CM009512.1.482 P32246 CCR1_HUMAN 64.486 0.859599 0.983099 CCR1 - C-C chemokine receptor type 1 - Homo sapiens (Human) - CCR1 gene Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Indicus|evm.model.CM009512.1.483 P32246 CCR1_HUMAN 84.507 0.994382 1.00282 CCR1 - C-C chemokine receptor type 1 - Homo sapiens (Human) - CCR1 gene Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Indicus|evm.model.CM009512.1.484 Q99567 NUP88_HUMAN 88.288 0.982143 0.151147 NUP88 - Nuclear pore complex protein Nup88 - Homo sapiens (Human) - NUP88 gene Component of nuclear pore complex. Indicus|evm.model.CM009512.1.485 P46094 XCR1_HUMAN 78.378 0.994012 1.003 XCR1 - Chemokine XC receptor 1 - Homo sapiens (Human) - XCR1 gene Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin. Indicus|evm.model.CM009512.1.486 Q9BQS8 FYCO1_HUMAN 77.417 0.997892 0.962788 FYCO1 - FYVE and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - FYCO1 gene May mediate microtubule plus end-directed vesicle transport. Indicus|evm.model.CM009512.1.487 Q1WLP9 CCR9_SHEEP 95.556 0.734151 1.33243 CCR9 - C-C chemokine receptor type 9 - Ovis aries (Sheep) - CCR9 gene Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level (By similarity). Indicus|evm.model.CM009512.1.488 Q3ZBL4 LZTL1_BOVIN 100.000 0.951673 0.899666 LZTFL1 - Leucine zipper transcription factor-like protein 1 - Bos taurus (Bovine) - LZTFL1 gene Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function (By similarity). Indicus|evm.model.CM009512.1.489 Q9NP91 S6A20_HUMAN 90.372 0.996627 1.00169 SLC6A20 - Sodium- and chloride-dependent transporter XTRP3 - Homo sapiens (Human) - SLC6A20 gene Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Involved in the transport of glycine. Indicus|evm.model.CM009512.1.490 A6QL88 SAC1_BOVIN 99.830 0.996599 1.0017 SACM1L - Phosphatidylinositol-3-phosphatase SAC1 - Bos taurus (Bovine) - SACM1L gene Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (By similarity). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (By similarity). Indicus|evm.model.CM009512.1.491 G5E5X0 LIMD1_BOVIN 99.703 0.997037 1.00148 LIMD1 - LIM domain-containing protein 1 - Bos taurus (Bovine) - LIMD1 gene Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation (By similarity). Indicus|evm.model.CM009512.1.492 Q5RDP4 SYLM_PONAB 86.489 0.99774 0.980066 LARS2 - Probable leucine--tRNA ligase, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - LARS2 gene Indicus|evm.model.CM009512.1.493 Q7YRK6 CX6B1_CARSF 91.860 0.977011 1.01163 COX6B1 - Cytochrome c oxidase subunit 6B1 - Carlito syrichta (Philippine tarsier) - COX6B1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.CM009512.1.494 Q9H5V8 CDCP1_HUMAN 77.871 0.773655 1.28947 CDCP1 - CUB domain-containing protein 1 precursor - Homo sapiens (Human) - CDCP1 gene May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Indicus|evm.model.CM009512.1.495 Q2KIS7 TETN_BOVIN 100.000 0.990148 1.00495 CLEC3B - Tetranectin precursor - Bos taurus (Bovine) - CLEC3B gene Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis (By similarity). Indicus|evm.model.CM009512.1.497 Q15024 EXOS7_HUMAN 96.907 0.993151 1.00344 EXOSC7 - Exosome complex component RRP42 - Homo sapiens (Human) - EXOSC7 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Indicus|evm.model.CM009512.1.498 Q9NYG2 ZDHC3_HUMAN 88.850 0.848665 1.12709 ZDHHC3 - Palmitoyltransferase ZDHHC3 - Homo sapiens (Human) - ZDHHC3 gene Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19001095, PubMed:21926431, PubMed:22240897, PubMed:23034182, PubMed:22314500). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (PubMed:22314500). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (PubMed:22240897). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes. Also constitutively palmitoylates DLG4. May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2 (PubMed:26535572). Indicus|evm.model.CM009512.1.499 Q2KIX3 TMM42_BOVIN 100.000 0.9875 1.00629 TMEM42 - Transmembrane protein 42 - Bos taurus (Bovine) - TMEM42 gene Indicus|evm.model.CM009512.1.500 Q93075 TATD2_HUMAN 58.333 0.62963 0.177398 TATDN2 - Putative deoxyribonuclease TATDN2 - Homo sapiens (Human) - TATDN2 gene Putative deoxyribonuclease. Indicus|evm.model.CM009512.1.501 Q3ZCC9 SEC13_BOVIN 100.000 0.651731 1.52484 SEC13 - Protein SEC13 homolog - Bos taurus (Bovine) - SEC13 gene Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum. Indicus|evm.model.CM009512.1.502 Q9R0K7 AT2B2_MOUSE 93.388 0.998339 1.00501 Atp2b2 - Plasma membrane calcium-transporting ATPase 2 - Mus musculus (Mouse) - Atp2b2 gene ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:9668038). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics (PubMed:17409239, PubMed:20083513). At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (PubMed:17409239, PubMed:20083513). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:9668038) (By similarity). Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (PubMed:15302868). Indicus|evm.model.CM009512.1.504 P31650 S6A11_MOUSE 94.622 0.954286 0.837321 Slc6a11 - Sodium- and chloride-dependent GABA transporter 3 - Mus musculus (Mouse) - Slc6a11 gene Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Can also transport beta-alanine and taurine. Indicus|evm.model.CM009512.1.505 P30531 SC6A1_HUMAN 97.663 0.996667 1.00167 SLC6A1 - Sodium- and chloride-dependent GABA transporter 1 - Homo sapiens (Human) - SLC6A1 gene Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Indicus|evm.model.CM009512.1.506 P30546 HRH1_BOVIN 98.778 0.995935 1.00204 HRH1 - Histamine H1 receptor - Bos taurus (Bovine) - HRH1 gene In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Indicus|evm.model.CM009512.1.507 O95352 ATG7_HUMAN 94.452 0.997159 1.00142 ATG7 - Ubiquitin-like modifier-activating enzyme ATG7 - Homo sapiens (Human) - ATG7 gene E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity). Indicus|evm.model.CM009512.1.508 Q14135 VGLL4_HUMAN 89.883 0.860544 1.01379 VGLL4 - Transcription cofactor vestigial-like protein 4 - Homo sapiens (Human) - VGLL4 gene May act as a specific coactivator for the mammalian TEFs. Indicus|evm.model.CM009512.1.509 Q32L81 TAM41_BOVIN 99.110 0.994083 1.00896 TAMM41 - Phosphatidate cytidylyltransferase, mitochondrial - Bos taurus (Bovine) - TAMM41 gene Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol. Indicus|evm.model.CM009512.1.510 P20396 TRH_HUMAN 71.605 0.460653 2.15289 TRH - Pro-thyrotropin-releasing hormone precursor - Homo sapiens (Human) - TRH gene As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes. Indicus|evm.model.CM009512.1.511 O94876 TMCC1_HUMAN 96.018 0.996937 1 TMCC1 - Transmembrane and coiled-coil domains protein 1 - Homo sapiens (Human) - TMCC1 gene Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Indicus|evm.model.CM009512.1.512 Q9Y4D7 PLXD1_HUMAN 90.682 0.942842 1.00883 PLXND1 - Plexin-D1 precursor - Homo sapiens (Human) - PLXND1 gene Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. Indicus|evm.model.CM009512.1.513 Q3HNG7 H18_BOVIN 83.860 0.991903 0.720117 H1-8 - Histone H1.8 - Bos taurus (Bovine) - H1-8 gene May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). Indicus|evm.model.CM009512.1.515 P02699 OPSD_BOVIN 100.000 0.994269 1.00287 RHO - Rhodopsin - Bos taurus (Bovine) - RHO gene Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins (PubMed:10926528, PubMed:12044163, PubMed:11972040, PubMed:16908857, PubMed:16586416, PubMed:17060607, PubMed:17449675, PubMed:18818650, PubMed:21389983, PubMed:22198838, PubMed:23579341, PubMed:25205354, PubMed:27458239). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:1396673, PubMed:15111114). Indicus|evm.model.CM009512.1.516 Q9HBG6 IF122_HUMAN 90.250 0.99839 1.00081 IFT122 - Intraflagellar transport protein 122 homolog - Homo sapiens (Human) - IFT122 gene As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (PubMed:27932497, PubMed:29220510). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). Indicus|evm.model.CM009512.1.517 O95243 MBD4_HUMAN 73.260 0.937388 0.963793 MBD4 - Methyl-CpG-binding domain protein 4 - Homo sapiens (Human) - MBD4 gene Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. Indicus|evm.model.CM009512.1.518 Q95LL8 EFC12_MACFA 64.645 0.996534 1.01406 EFCAB12 - EF-hand calcium-binding domain-containing protein 12 - Macaca fascicularis (Crab-eating macaque) - EFCAB12 gene Indicus|evm.model.CM009512.1.519 Q3SZQ6 RL32_BOVIN 100.000 0.985294 1.00741 RPL32 - 60S ribosomal protein L32 - Bos taurus (Bovine) - RPL32 gene cytosolic large ribosomal subunit Indicus|evm.model.CM009512.1.520 O75155 CAND2_HUMAN 91.019 0.99834 0.974919 CAND2 - Cullin-associated NEDD8-dissociated protein 2 - Homo sapiens (Human) - CAND2 gene Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Indicus|evm.model.CM009512.1.521 Q8WWA1 TMM40_HUMAN 82.075 0.96789 0.935622 TMEM40 - Transmembrane protein 40 - Homo sapiens (Human) - TMEM40 gene Indicus|evm.model.CM009512.1.522 A7E3S4 RAF1_BOVIN 97.770 0.85623 0.483025 RAF1 - RAF proto-oncogene serine/threonine-protein kinase - Bos taurus (Bovine) - RAF1 gene Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity). Indicus|evm.model.CM009512.1.523 Q9ERV1 MKRN2_MOUSE 95.349 0.831169 0.370192 Mkrn2 - Probable E3 ubiquitin-protein ligase makorin-2 - Mus musculus (Mouse) - Mkrn2 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Indicus|evm.model.CM009512.1.524 A7E3S4 RAF1_BOVIN 100.000 0.723837 0.530864 RAF1 - RAF proto-oncogene serine/threonine-protein kinase - Bos taurus (Bovine) - RAF1 gene Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity). Indicus|evm.model.CM009512.1.525 A7E3S4 RAF1_BOVIN 100.000 0.942177 0.453704 RAF1 - RAF proto-oncogene serine/threonine-protein kinase - Bos taurus (Bovine) - RAF1 gene Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity). Indicus|evm.model.CM009512.1.526 Q9H000 MKRN2_HUMAN 84.211 0.662005 1.03125 MKRN2 - Probable E3 ubiquitin-protein ligase makorin-2 - Homo sapiens (Human) - MKRN2 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Indicus|evm.model.CM009512.1.527 H3BPM6 MKROS_HUMAN 76.190 0.981221 0.955157 MKRN2OS - MKRN2 opposite strand protein - Homo sapiens (Human) - MKRN2OS gene Indicus|evm.model.CM009512.1.528 Q8NCE0 SEN2_HUMAN 71.459 0.995652 0.989247 TSEN2 - tRNA-splicing endonuclease subunit Sen2 - Homo sapiens (Human) - TSEN2 gene Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity. Indicus|evm.model.CM009512.1.530 O18971 PPARG_BOVIN 100.000 0.995798 0.942574 PPARG - Peroxisome proliferator-activated receptor gamma - Bos taurus (Bovine) - PPARG gene Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels. Indicus|evm.model.CM009512.1.531 Q92777 SYN2_HUMAN 97.162 0.952083 0.824742 SYN2 - Synapsin-2 - Homo sapiens (Human) - SYN2 gene Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity). Indicus|evm.model.CM009512.1.532 Q32L81 TAM41_BOVIN 79.574 0.532995 1.17612 TAMM41 - Phosphatidate cytidylyltransferase, mitochondrial - Bos taurus (Bovine) - TAMM41 gene Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol. Indicus|evm.model.CM009512.1.533 Q9H1K0 RBNS5_HUMAN 87.023 0.997449 1 RBSN - Rabenosyn-5 - Homo sapiens (Human) - RBSN gene Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). Indicus|evm.model.CM009512.1.534 P82669 RT25_BOVIN 100.000 0.988506 1.00578 MRPS25 - 28S ribosomal protein S25, mitochondrial - Bos taurus (Bovine) - MRPS25 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009512.1.535 P49116 NR2C2_HUMAN 97.819 0.944444 1.05705 NR2C2 - Nuclear receptor subfamily 2 group C member 2 - Homo sapiens (Human) - NR2C2 gene Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. Indicus|evm.model.CM009512.1.536 Q6ZNL6 FGD5_HUMAN 72.270 0.998641 1.00684 FGD5 - FYVE, RhoGEF and PH domain-containing protein 5 - Homo sapiens (Human) - FGD5 gene Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. Indicus|evm.model.CM009512.1.537 Q8ND61 CC020_HUMAN 68.668 0.997802 1.00664 C3orf20 - Uncharacterized protein C3orf20 - Homo sapiens (Human) - C3orf20 gene cytoplasm Indicus|evm.model.CM009512.1.538 Q6PII3 CC174_HUMAN 89.722 0.995726 1.00214 CCDC174 - Coiled-coil domain-containing protein 174 - Homo sapiens (Human) - CCDC174 gene Probably involved in neuronal development. Indicus|evm.model.CM009512.1.539 Q9C0E4 GRIP2_HUMAN 89.423 0.988539 1.00384 GRIP2 - Glutamate receptor-interacting protein 2 - Homo sapiens (Human) - GRIP2 gene May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Indicus|evm.model.CM009512.1.540 Q9MZ34 SC6A6_BOVIN 99.839 0.968701 1.03065 SLC6A6 - Sodium- and chloride-dependent taurine transporter - Bos taurus (Bovine) - SLC6A6 gene Sodium-dependent taurine and beta-alanine transporter. Indicus|evm.model.CM009512.1.543 P62311 LSM3_MOUSE 100.000 0.980583 1.0098 Lsm3 - U6 snRNA-associated Sm-like protein LSm3 - Mus musculus (Mouse) - Lsm3 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Indicus|evm.model.CM009512.1.544 Q01831 XPC_HUMAN 73.517 0.997856 0.992553 XPC - DNA repair protein complementing XP-C cells - Homo sapiens (Human) - XPC gene Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:19609301, PubMed:20649465, PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). Indicus|evm.model.CM009512.1.545 Q9DBS1 TMM43_MOUSE 93.250 0.995012 1.0025 Tmem43 - Transmembrane protein 43 - Mus musculus (Mouse) - Tmem43 gene May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. Indicus|evm.model.CM009512.1.546 Q2KHZ4 MIA40_BOVIN 100.000 0.985507 1.0073 CHCHD4 - Mitochondrial intermembrane space import and assembly protein 40 - Bos taurus (Bovine) - CHCHD4 gene Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes. Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake. Indicus|evm.model.CM009512.1.547 Q5J3L6 VR100_RAT 48.899 0.349462 1.71166 Vom1r100 - Vomeronasal type-1 receptor 100 - Rattus norvegicus (Rat) - Vom1r100 gene Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior. Indicus|evm.model.CM009512.1.548 Q1KYK5 WNT7A_PONPY 98.551 0.790805 1.24642 WNT7A - Protein Wnt-7a precursor - Pongo pygmaeus (Bornean orangutan) - WNT7A gene Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity). Indicus|evm.model.CM009512.1.551 P37889 FBLN2_MOUSE 80.131 0.995033 0.989353 Fbln2 - Fibulin-2 precursor - Mus musculus (Mouse) - Fbln2 gene Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN. Indicus|evm.model.CM009512.1.553 Q9GKU5 HDA11_MACFA 91.884 0.849383 1.16715 HDAC11 - Histone deacetylase 11 - Macaca fascicularis (Crab-eating macaque) - HDAC11 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Indicus|evm.model.CM009512.1.554 Q8TEM1 PO210_HUMAN 84.044 0.964154 1.0053 NUP210 - Nuclear pore membrane glycoprotein 210 precursor - Homo sapiens (Human) - NUP210 gene Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. Indicus|evm.model.CM009512.1.558 A0A0G2JUG7 IQEC1_RAT 95.789 0.662005 0.891892 Iqsec1 - IQ motif and SEC7 domain-containing protein 1 - Rattus norvegicus (Rat) - Iqsec1 gene Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. Involved in neuronal development (By similarity). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (PubMed:20547133). Indicus|evm.model.CM009512.1.559 Q9H845 ACAD9_HUMAN 85.323 0.995169 1 ACAD9 - Complex I assembly factor ACAD9, mitochondrial precursor - Homo sapiens (Human) - ACAD9 gene As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852). This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852). Indicus|evm.model.CM009512.1.560 Q6ZUG5 YC006_HUMAN 66.818 0.388393 1.95804 Uncharacterized protein FLJ43738 - Homo sapiens (Human) Indicus|evm.model.CM009512.1.561 P0CG25 EFCC1_BOVIN 92.544 0.945833 0.40201 EFCC1 - EF-hand and coiled-coil domain-containing protein 1 - Bos taurus (Bovine) - EFCC1 gene cytosol Indicus|evm.model.CM009512.1.562 P0CG25 EFCC1_BOVIN 99.541 0.939394 0.386935 EFCC1 - EF-hand and coiled-coil domain-containing protein 1 - Bos taurus (Bovine) - EFCC1 gene cytosol Indicus|evm.model.CM009512.1.563 P14770 GPIX_HUMAN 68.212 0.828729 1.0226 GP9 - Platelet glycoprotein IX precursor - Homo sapiens (Human) - GP9 gene The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. Indicus|evm.model.CM009512.1.564 Q53B90 RAB43_RAT 86.747 0.911111 0.428571 Rab43 - Ras-related protein Rab-43 - Rattus norvegicus (Rat) - Rab43 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Indicus|evm.model.CM009512.1.565 Q86YS6 RAB43_HUMAN 82.667 0.578125 0.603774 RAB43 - Ras-related protein Rab-43 - Homo sapiens (Human) - RAB43 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Indicus|evm.model.CM009512.1.566 Q6AYB3 ISY1_RAT 95.406 0.989474 1.00352 Isy1 - Pre-mRNA-splicing factor ISY1 homolog - Rattus norvegicus (Rat) - Isy1 gene Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome. Indicus|evm.model.CM009512.1.567 P62634 CNBP_RAT 100.000 0.988764 1.00565 Cnbp - Cellular nucleic acid-binding protein - Rattus norvegicus (Rat) - Cnbp gene Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression. Indicus|evm.model.CM009512.1.568 P53620 COPG1_BOVIN 99.886 0.997714 1.00114 COPG1 - Coatomer subunit gamma-1 - Bos taurus (Bovine) - COPG1 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). Indicus|evm.model.CM009512.1.569 Q96FZ2 HMCES_HUMAN 80.508 0.994366 1.00282 HMCES - Abasic site processing protein HMCES - Homo sapiens (Human) - HMCES gene Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235915, PubMed:31235913). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913). The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). Indicus|evm.model.CM009512.1.570 Q92522 H1X_HUMAN 90.643 0.515152 1.5493 H1-10 - Histone H1.10 - Homo sapiens (Human) - H1-10 gene Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. Indicus|evm.model.CM009512.1.571 Q3T0F5 RAB7A_BOVIN 99.517 0.990385 1.00483 RAB7A - Ras-related protein Rab-7a - Bos taurus (Bovine) - RAB7A gene Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By similarity). Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes (By similarity). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses (By similarity). Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium) (By similarity). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (By similarity). Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (By similarity). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Required for vesicular trafficking and cell surface expression of ACE2 (By similarity). May play a role in PRPH neuronal intermediate filament assembly (By similarity). Indicus|evm.model.CM009512.1.573 Q9CPR4 RL17_MOUSE 95.758 0.901099 0.98913 Rpl17 - 60S ribosomal protein L17 - Mus musculus (Mouse) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009512.1.574 E2RQ08 RPN1_CANLF 95.402 0.77071 1.11367 RPN1 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor - Canis lupus familiaris (Dog) - RPN1 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Indicus|evm.model.CM009512.1.576 P23769 GATA2_HUMAN 95.010 0.995842 1.00208 GATA2 - Endothelial transcription factor GATA-2 - Homo sapiens (Human) - GATA2 gene Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Indicus|evm.model.CM009512.1.578 Q8NHS0 DNJB8_HUMAN 86.638 0.991379 1 DNAJB8 - DnaJ homolog subfamily B member 8 - Homo sapiens (Human) - DNAJB8 gene Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins. Indicus|evm.model.CM009512.1.579 Q9JHW4 SELB_MOUSE 86.318 0.860908 1.17153 Eefsec - Selenocysteine-specific elongation factor - Mus musculus (Mouse) - Eefsec gene Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP. Indicus|evm.model.CM009512.1.580 P60123 RUVB1_RAT 99.342 0.995624 1.00219 Ruvbl1 - RuvB-like 1 - Rattus norvegicus (Rat) - Ruvbl1 gene Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (By similarity). Essential for cell proliferation (By similarity). May be able to bind plasminogen at cell surface and enhance plasminogen activation (By similarity). Indicus|evm.model.CM009512.1.581 Q5EA68 S61A1_BOVIN 100.000 0.995807 1.0021 SEC61A1 - Protein transport protein Sec61 subunit alpha isoform 1 - Bos taurus (Bovine) - SEC61A1 gene Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity). Indicus|evm.model.CM009512.1.583 Q3ZCT8 KBTBC_HUMAN 88.406 0.99359 1.00161 KBTBD12 - Kelch repeat and BTB domain-containing protein 12 - Homo sapiens (Human) - KBTBD12 gene Indicus|evm.model.CM009512.1.584 Q99685 MGLL_HUMAN 85.809 0.961783 1.0363 MGLL - Monoglyceride lipase - Homo sapiens (Human) - MGLL gene Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). Indicus|evm.model.CM009512.1.585 Q5XIU1 ABTB1_RAT 83.054 0.995754 0.985356 Abtb1 - Ankyrin repeat and BTB/POZ domain-containing protein 1 - Rattus norvegicus (Rat) - Abtb1 gene May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity). Indicus|evm.model.CM009512.1.586 Q9NZ53 PDXL2_HUMAN 68.995 0.975779 0.955372 PODXL2 - Podocalyxin-like protein 2 precursor - Homo sapiens (Human) - PODXL2 gene Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. Indicus|evm.model.CM009512.1.587 P49736 MCM2_HUMAN 96.074 0.438069 1.2146 MCM2 - DNA replication licensing factor MCM2 - Homo sapiens (Human) - MCM2 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis. Indicus|evm.model.CM009512.1.588 Q791F6 TPRA1_RAT 78.090 0.895522 0.907859 Tpra1 - Transmembrane protein adipocyte-associated 1 - Rattus norvegicus (Rat) - Tpra1 gene plasma membrane, embryonic cleavage, negative regulation of mitotic cell cycle phase transition Indicus|evm.model.CM009512.1.594 Q9UIW2 PLXA1_HUMAN 95.584 0.630279 1.17405 PLXNA1 - Plexin-A1 precursor - Homo sapiens (Human) - PLXNA1 gene Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). Indicus|evm.model.CM009512.1.595 Q86VQ6 TRXR3_HUMAN 83.394 0.726428 1.17107 TXNRD3 - Thioredoxin reductase 3 - Homo sapiens (Human) - TXNRD3 gene Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). Indicus|evm.model.CM009512.1.596 Q32PB5 CC022_BOVIN 94.667 0.72549 0.761194 Uncharacterized protein C3orf22 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009512.1.597 Q8VC12 HUTU_MOUSE 88.889 0.507159 1.96302 Uroc1 - Urocanate hydratase - Mus musculus (Mouse) - Uroc1 gene cytosol, urocanate hydratase activity, histidine catabolic process Indicus|evm.model.CM009512.1.598 Q5RFM9 AL1L1_PONAB 90.980 0.64209 1.54878 ALDH1L1 - Cytosolic 10-formyltetrahydrofolate dehydrogenase - Pongo abelii (Sumatran orangutan) - ALDH1L1 gene Indicus|evm.model.CM009512.1.599 Q9UIH9 KLF15_HUMAN 78.935 0.91762 1.05048 KLF15 - Krueppel-like factor 15 - Homo sapiens (Human) - KLF15 gene Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. Indicus|evm.model.CM009512.1.600 Q494V2 CP100_HUMAN 68.301 0.975806 1.01473 CFAP100 - Cilia- and flagella-associated protein 100 - Homo sapiens (Human) - CFAP100 gene May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. Indicus|evm.model.CM009512.1.601 Q9NQV7 PRDM9_HUMAN 78.846 0.579545 0.098434 PRDM9 - Histone-lysine N-methyltransferase PRDM9 - Homo sapiens (Human) - PRDM9 gene Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:24634223, PubMed:24095733, PubMed:26833727). Also can methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24095733, PubMed:24634223, PubMed:26833727). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (By similarity). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:26833727). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (By similarity). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (By similarity). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (By similarity). In addition performs automethylation (By similarity). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (By similarity). Indicus|evm.model.CM009513.1.3 A1A4L5 ALKB8_BOVIN 94.340 0.9875 0.240964 ALKBH8 - Alkylated DNA repair protein alkB homolog 8 - Bos taurus (Bovine) - ALKBH8 gene Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity). Indicus|evm.model.CM009513.1.4 A1A4L5 ALKB8_BOVIN 91.057 0.897059 0.204819 ALKBH8 - Alkylated DNA repair protein alkB homolog 8 - Bos taurus (Bovine) - ALKBH8 gene Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity). Indicus|evm.model.CM009513.1.5 P33610 PRI2_MOUSE 86.111 0.483622 1.02772 Prim2 - DNA primase large subunit - Mus musculus (Mouse) - Prim2 gene Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:8026492, PubMed:8253737). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:8253737). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:8253737). Stabilizes and modulates the activity of the catalytic subunit (PubMed:8253737). Indicus|evm.model.CM009513.1.7 Q9ULC3 RAB23_HUMAN 94.937 0.991597 1.00422 RAB23 - Ras-related protein Rab-23 precursor - Homo sapiens (Human) - RAB23 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. Indicus|evm.model.CM009513.1.8 Q91YN9 BAG2_MOUSE 90.751 0.830918 0.985714 Bag2 - BAG family molecular chaperone regulator 2 - Mus musculus (Mouse) - Bag2 gene Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Indicus|evm.model.CM009513.1.9 Q9HCI6 K1586_HUMAN 84.211 0.0531814 1.33799 KIAA1586 - E3 SUMO-protein ligase KIAA1586 - Homo sapiens (Human) - KIAA1586 gene E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493). Indicus|evm.model.CM009513.1.10 Q9HCI6 K1586_HUMAN 78.947 0.405914 0.472681 KIAA1586 - E3 SUMO-protein ligase KIAA1586 - Homo sapiens (Human) - KIAA1586 gene E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493). Indicus|evm.model.CM009513.1.11 Q5SZJ8 BEND6_HUMAN 91.398 0.992857 1.00358 BEND6 - BEN domain-containing protein 6 - Homo sapiens (Human) - BEND6 gene Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214). Indicus|evm.model.CM009513.1.12 Q03001 DYST_HUMAN 82.630 0.976383 1.02919 DST - Dystonin - Homo sapiens (Human) - DST gene Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). Indicus|evm.model.CM009513.1.13 Q96P44 COLA1_HUMAN 72.470 0.997636 0.884013 COL21A1 - Collagen alpha-1(XXI) chain precursor - Homo sapiens (Human) - COL21A1 gene collagen-containing extracellular matrix, cytosol, endoplasmic reticulum lumen, extracellular region, extracellular space, collagen fibril organization Indicus|evm.model.CM009513.1.14 P22003 BMP5_HUMAN 95.187 0.994667 0.825991 BMP5 - Bone morphogenetic protein 5 precursor - Homo sapiens (Human) - BMP5 gene Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:29321139, PubMed:11580864). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566). Indicus|evm.model.CM009513.1.15 D4A5C3 HMGC2_RAT 88.889 0.583333 0.489796 Hmgcll1 - 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic - Rattus norvegicus (Rat) - Hmgcll1 gene Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. Indicus|evm.model.CM009513.1.16 Q8TB92 HMGC2_HUMAN 86.722 0.990783 0.586486 HMGCLL1 - 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic - Homo sapiens (Human) - HMGCLL1 gene Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. Indicus|evm.model.CM009513.1.17 Q6UXV0 GFRAL_HUMAN 68.954 0.704388 1.09898 GFRAL - GDNF family receptor alpha-like precursor - Homo sapiens (Human) - GFRAL gene Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. Indicus|evm.model.CM009513.1.18 Q9TUP7 OX2R_CANLF 98.333 0.99446 0.813063 HCRTR2 - Orexin receptor type 2 - Canis lupus familiaris (Dog) - HCRTR2 gene Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Indicus|evm.model.CM009513.1.19 O62809 OX2R_PIG 100.000 0.663636 0.247748 HCRTR2 - Orexin receptor type 2 - Sus scrofa (Pig) - HCRTR2 gene Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Indicus|evm.model.CM009513.1.20 Q5T0W9 FA83B_HUMAN 82.966 0.99768 0.852621 FAM83B - Protein FAM83B - Homo sapiens (Human) - FAM83B gene Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. Indicus|evm.model.CM009513.1.21 Q5T0W9 FA83B_HUMAN 89.262 0.919255 0.159248 FAM83B - Protein FAM83B - Homo sapiens (Human) - FAM83B gene Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. Indicus|evm.model.CM009513.1.22 Q3SZI1 TINAG_BOVIN 100.000 0.890547 0.844538 TINAG - Tubulointerstitial nephritis antigen - Bos taurus (Bovine) - TINAG gene Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein (By similarity). Indicus|evm.model.CM009513.1.24 Q5VWP3 MLIP_HUMAN 86.286 0.212195 1.79039 MLIP - Muscular LMNA-interacting protein - Homo sapiens (Human) - MLIP gene Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD. Indicus|evm.model.CM009513.1.25 Q9BTT6 LRRC1_HUMAN 94.851 0.984375 0.977099 LRRC1 - Leucine-rich repeat-containing protein 1 - Homo sapiens (Human) - LRRC1 gene cytosol Indicus|evm.model.CM009513.1.26 Q9H511 KLH31_HUMAN 91.987 0.981102 1.00158 KLHL31 - Kelch-like protein 31 - Homo sapiens (Human) - KLHL31 gene Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). Indicus|evm.model.CM009513.1.27 P48506 GSH1_HUMAN 94.035 0.995305 1.00314 GCLC - Glutamate--cysteine ligase catalytic subunit - Homo sapiens (Human) - GCLC gene cytosol, glutamate-cysteine ligase complex, ADP binding, glutamate binding, glutamate-cysteine ligase activity, magnesium ion binding, blood vessel diameter maintenance, cell redox homeostasis, cysteine metabolic process, glutamate metabolic process Indicus|evm.model.CM009513.1.28 P01911 DRB1_HUMAN 67.117 0.638728 1.30075 HLA-DRB1 - HLA class II histocompatibility antigen, DRB1 beta chain precursor - Homo sapiens (Human) - HLA-DRB1 gene A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:22327072, PubMed:27591323, PubMed:8642306, PubMed:15265931, PubMed:31495665, PubMed:16148104). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819). Indicus|evm.model.CM009513.1.29 P15981 HA2D_PIG 66.135 0.984252 0.996078 SLA class II histocompatibility antigen, DQ haplotype D alpha chain precursor - Sus scrofa (Pig) Indicus|evm.model.CM009513.1.30 P05538 DQB2_HUMAN 67.391 0.656069 1.29104 HLA-DQB2 - HLA class II histocompatibility antigen, DQ beta 2 chain precursor - Homo sapiens (Human) - HLA-DQB2 gene Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. Indicus|evm.model.CM009513.1.31 P13765 DOB_HUMAN 76.296 0.988971 0.996337 HLA-DOB - HLA class II histocompatibility antigen, DO beta chain precursor - Homo sapiens (Human) - HLA-DOB gene Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. Indicus|evm.model.CM009513.1.32 Q03519 TAP2_HUMAN 77.289 0.876006 0.905248 TAP2 - Antigen peptide transporter 2 - Homo sapiens (Human) - TAP2 gene ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules (PubMed:25656091, PubMed:25377891). Uses the chemical energy of ATP to export peptides against the concentration gradient (PubMed:25377891). During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle (PubMed:25377891, PubMed:25656091, PubMed:11274390). Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Proline at position 2 has the most destabilizing effect (PubMed:7500034, PubMed:9256420, PubMed:11274390). As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation (PubMed:26611325, PubMed:1538751, PubMed:25377891). Indicus|evm.model.CM009513.1.33 P36371 TAP2_MOUSE 78.648 0.960616 0.831909 Tap2 - Antigen peptide transporter 2 - Mus musculus (Mouse) - Tap2 gene ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules. Uses the chemical energy of ATP to export peptides against the concentration gradient. During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle. As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation. Indicus|evm.model.CM009513.1.34 Q3T112 PSB8_BOVIN 97.101 0.99278 1.00362 PSMB8 - Proteasome subunit beta type-8 precursor - Bos taurus (Bovine) - PSMB8 gene The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity). May participate in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity). Required for adipocyte differentiation (By similarity). Indicus|evm.model.CM009513.1.35 Q28433 TAP1_GORGO 76.267 0.997337 1.00401 TAP1 - Antigen peptide transporter 1 - Gorilla gorilla gorilla (Western lowland gorilla) - TAP1 gene ABC transporter associated with antigen processing. In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules. Uses the chemical energy of ATP to export peptides against the concentration gradient. During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle. As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation. Indicus|evm.model.CM009513.1.36 Q3SZC2 PSB9_BOVIN 100.000 0.990909 1.00457 PSMB9 - Proteasome subunit beta type-9 precursor - Bos taurus (Bovine) - PSMB9 gene The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity). Indicus|evm.model.CM009513.1.37 Q5R893 H2B1_PONAB 96.032 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009513.1.38 P28068 DMB_HUMAN 75.304 0.935361 1 HLA-DMB - HLA class II histocompatibility antigen, DM beta chain precursor - Homo sapiens (Human) - HLA-DMB gene Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Indicus|evm.model.CM009513.1.39 P28067 DMA_HUMAN 74.178 0.985981 0.819923 HLA-DMA - HLA class II histocompatibility antigen, DM alpha chain precursor - Homo sapiens (Human) - HLA-DMA gene Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Indicus|evm.model.CM009513.1.40 P06340 DOA_HUMAN 74.545 0.99095 0.884 HLA-DOA - HLA class II histocompatibility antigen, DO alpha chain precursor - Homo sapiens (Human) - HLA-DOA gene Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. Indicus|evm.model.CM009513.1.43 Q32S26 BRD2_BOVIN 100.000 0.997512 1.00125 BRD2 - Bromodomain-containing protein 2 - Bos taurus (Bovine) - BRD2 gene Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis (By similarity). Indicus|evm.model.CM009513.1.44 Q32S24 COBA2_BOVIN 97.350 0.998819 0.97523 COL11A2 - Collagen alpha-2(XI) chain precursor - Bos taurus (Bovine) - COL11A2 gene May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. Indicus|evm.model.CM009513.1.45 P28702 RXRB_HUMAN 97.765 0.996276 1.0075 RXRB - Retinoic acid receptor RXR-beta - Homo sapiens (Human) - RXRB gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE). Indicus|evm.model.CM009513.1.46 Q5TJF6 S39A7_CANLF 93.603 0.995745 1.00213 SLC39A7 - Zinc transporter SLC39A7 - Canis lupus familiaris (Dog) - SLC39A7 gene Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). Indicus|evm.model.CM009513.1.47 Q9XT00 DHB8_PIG 90.347 0.992308 1.00386 HSD17B8 - (3R)-3-hydroxyacyl-CoA dehydrogenase - Sus scrofa (Pig) - HSD17B8 gene Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex, acts as scaffold protein, required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference, this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD+(H). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters. NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol. Indicus|evm.model.CM009513.1.48 A2T6X5 RING1_PANTR 98.677 0.891253 1.12202 RING1 - E3 ubiquitin-protein ligase RING1 - Pan troglodytes (Chimpanzee) - RING1 gene Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity). Indicus|evm.model.CM009513.1.49 Q2T9M4 DRC7_BOVIN 92.453 0.702703 0.0848624 DRC7 - Dynein regulatory complex subunit 7 - Bos taurus (Bovine) - DRC7 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility. Indicus|evm.model.CM009513.1.50 Q8N1B4 VPS52_HUMAN 91.120 0.997429 1.07607 VPS52 - Vacuolar protein sorting-associated protein 52 homolog - Homo sapiens (Human) - VPS52 gene Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). Indicus|evm.model.CM009513.1.51 P62271 RS18_RAT 100.000 0.986928 1.00658 Rps18 - 40S ribosomal protein S18 - Rattus norvegicus (Rat) - Rps18 gene Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. Indicus|evm.model.CM009513.1.52 Q5TJE8 B3GT4_CANLF 82.289 0.952507 0.989556 B3GALT4 - Beta-1,3-galactosyltransferase 4 - Canis lupus familiaris (Dog) - B3GALT4 gene Involved in GM1/GD1B/GA1 ganglioside biosynthesis. Indicus|evm.model.CM009513.1.53 O15213 WDR46_HUMAN 87.725 0.9967 0.993443 WDR46 - WD repeat-containing protein 46 - Homo sapiens (Human) - WDR46 gene Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. Indicus|evm.model.CM009513.1.54 Q17Q89 PFD6_BOVIN 100.000 0.984615 1.00775 PFDN6 - Prefoldin subunit 6 - Bos taurus (Bovine) - PFDN6 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Indicus|evm.model.CM009513.1.55 Q5TJE5 RGL2_CANLF 91.933 0.997436 1 RGL2 - Ral guanine nucleotide dissociation stimulator-like 2 - Canis lupus familiaris (Dog) - RGL2 gene Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). Indicus|evm.model.CM009513.1.56 O15533 TPSN_HUMAN 82.367 0.957589 1 TAPBP - Tapasin precursor - Homo sapiens (Human) - TAPBP gene Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). Indicus|evm.model.CM009513.1.57 Q5TJE2 ZBT22_CANLF 90.981 0.982677 0.992188 ZBTB22 - Zinc finger and BTB domain-containing protein 22 - Canis lupus familiaris (Dog) - ZBTB22 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.58 Q5TJE1 DAXX_CANLF 86.916 0.997312 1.0095 DAXX - Death domain-associated protein 6 - Canis lupus familiaris (Dog) - DAXX gene Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX (By similarity). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (By similarity). Indicus|evm.model.CM009513.1.59 Q5STR5 SIM40_HUMAN 79.221 0.938272 1.02532 SMIM40 - Small integral membrane protein 40 - Homo sapiens (Human) - SMIM40 gene Indicus|evm.model.CM009513.1.61 Q9BW19 KIFC1_HUMAN 86.181 0.997019 0.997028 KIFC1 - Kinesin-like protein KIFC1 - Homo sapiens (Human) - KIFC1 gene Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). Indicus|evm.model.CM009513.1.62 O43189 PHF1_HUMAN 96.649 0.996479 1.00176 PHF1 - PHD finger protein 1 - Homo sapiens (Human) - PHF1 gene Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. Indicus|evm.model.CM009513.1.63 P69678 CUTA_BOVIN 98.305 0.988764 1.01136 CUTA - Protein CutA precursor - Bos taurus (Bovine) - CUTA gene May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE). Indicus|evm.model.CM009513.1.64 Q96PV0 SYGP1_HUMAN 99.090 0.998484 0.98213 SYNGAP1 - Ras/Rap GTPase-activating protein SynGAP - Homo sapiens (Human) - SYNGAP1 gene Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). Indicus|evm.model.CM009513.1.65 Q96C00 ZBTB9_HUMAN 85.021 0.995671 0.976744 ZBTB9 - Zinc finger and BTB domain-containing protein 9 - Homo sapiens (Human) - ZBTB9 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.66 Q16611 BAK_HUMAN 86.256 0.990566 1.00474 BAK1 - Bcl-2 homologous antagonist/killer - Homo sapiens (Human) - BAK1 gene Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. Indicus|evm.model.CM009513.1.67 Q5YKI7 GGNB1_HUMAN 63.551 0.27381 3.08257 GGNBP1 - Putative gametogenetin-binding protein 1 - Homo sapiens (Human) - GGNBP1 gene May be involved in spermatogenesis. Indicus|evm.model.CM009513.1.68 Q8WN95 ITPR3_BOVIN 99.700 0.99925 1.00038 ITPR3 - Inositol 1,4,5-trisphosphate receptor type 3 - Bos taurus (Bovine) - ITPR3 gene Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Indicus|evm.model.CM009513.1.69 Q3SZ13 UQCC2_BOVIN 81.618 0.982143 0.823529 UQCC2 - Ubiquinol-cytochrome-c reductase complex assembly factor 2 precursor - Bos taurus (Bovine) - UQCC2 gene Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability. Indicus|evm.model.CM009513.1.70 Q96PC2 IP6K3_HUMAN 79.024 0.994859 0.94878 IP6K3 - Inositol hexakisphosphate kinase 3 - Homo sapiens (Human) - IP6K3 gene Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Indicus|evm.model.CM009513.1.71 Q8NC56 LEMD2_HUMAN 96.516 0.913738 0.622266 LEMD2 - LEM domain-containing protein 2 - Homo sapiens (Human) - LEMD2 gene Involved in nuclear structure organization (PubMed:16339967). Required for maintaining the integrity of the nuclear envelope (PubMed:17097643). Indicus|evm.model.CM009513.1.72 O62820 MOTI_BOVIN 98.246 0.660819 1.48696 MLN - Promotilin precursor - Bos taurus (Bovine) - MLN gene Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle. Indicus|evm.model.CM009513.1.73 Q14833 GRM4_HUMAN 93.311 0.997699 0.952851 GRM4 - Metabotropic glutamate receptor 4 precursor - Homo sapiens (Human) - GRM4 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. Indicus|evm.model.CM009513.1.76 P17096 HMGA1_HUMAN 88.785 0.979381 0.906542 HMGA1 - High mobility group protein HMG-I/HMG-Y - Homo sapiens (Human) - HMGA1 gene HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Indicus|evm.model.CM009513.1.77 A2VE79 NUDT3_BOVIN 100.000 0.297521 2.11047 NUDT3 - Diphosphoinositol polyphosphate phosphohydrolase 1 - Bos taurus (Bovine) - NUDT3 gene Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity). Indicus|evm.model.CM009513.1.78 P46783 RS10_HUMAN 100.000 0.987952 1.00606 RPS10 - 40S ribosomal protein S10 - Homo sapiens (Human) - RPS10 gene Component of the 40S ribosomal subunit. Indicus|evm.model.CM009513.1.79 A7MBI0 PACN1_BOVIN 100.000 0.963043 1.03604 PACSIN1 - Protein kinase C and casein kinase substrate in neurons protein 1 - Bos taurus (Bovine) - PACSIN1 gene Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Indicus|evm.model.CM009513.1.80 O95238 SPDEF_HUMAN 92.239 0.826733 1.20597 SPDEF - SAM pointed domain-containing Ets transcription factor - Homo sapiens (Human) - SPDEF gene May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. Indicus|evm.model.CM009513.1.81 Q3TT38 ILRUN_MOUSE 100.000 0.940092 0.745704 Ilrun - Protein ILRUN - Mus musculus (Mouse) - Ilrun gene Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP. Indicus|evm.model.CM009513.1.82 F6TFD9 RU1C_MACMU 100.000 0.9875 1.00629 SNRPC - U1 small nuclear ribonucleoprotein C - Macaca mulatta (Rhesus macaque) - SNRPC gene Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Indicus|evm.model.CM009513.1.83 Q6BDS2 URFB1_HUMAN 88.435 0.998614 1.00208 UHRF1BP1 - UHRF1-binding protein 1 - Homo sapiens (Human) - UHRF1BP1 gene May act as a negative regulator of cell growth. Indicus|evm.model.CM009513.1.84 Q5RA91 TAF11_PONAB 92.417 0.990521 1 TAF11 - Transcription initiation factor TFIID subunit 11 - Pongo abelii (Sumatran orangutan) - TAF11 gene Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). Indicus|evm.model.CM009513.1.85 Q92625 ANS1A_HUMAN 88.190 0.998276 1.02293 ANKS1A - Ankyrin repeat and SAM domain-containing protein 1A - Homo sapiens (Human) - ANKS1A gene Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). Indicus|evm.model.CM009513.1.87 Q8WWU5 TCP11_HUMAN 79.365 0.996 0.994036 TCP11 - T-complex protein 11 homolog - Homo sapiens (Human) - TCP11 gene Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway. Indicus|evm.model.CM009513.1.88 Q8IX30 SCUB3_HUMAN 96.878 0.997988 1.00101 SCUBE3 - Signal peptide, CUB and EGF-like domain-containing protein 3 precursor - Homo sapiens (Human) - SCUBE3 gene Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. Indicus|evm.model.CM009513.1.89 P36508 ZNF76_HUMAN 93.684 0.996497 1.00175 ZNF76 - Zinc finger protein 76 - Homo sapiens (Human) - ZNF76 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.90 Q9H4E7 DEFI6_HUMAN 93.502 0.996835 1.00158 DEF6 - Differentially expressed in FDCP 6 homolog - Homo sapiens (Human) - DEF6 gene Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). Indicus|evm.model.CM009513.1.91 Q03181 PPARD_HUMAN 95.000 0.518913 1.91837 PPARD - Peroxisome proliferator-activated receptor delta - Homo sapiens (Human) - PPARD gene Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Indicus|evm.model.CM009513.1.92 Q9HB96 FANCE_HUMAN 78.343 0.977819 1.00933 FANCE - Fanconi anemia group E protein - Homo sapiens (Human) - FANCE gene As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Indicus|evm.model.CM009513.1.93 P62907 RL10A_RAT 100.000 0.990826 1.00461 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Indicus|evm.model.CM009513.1.94 Q99594 TEAD3_HUMAN 92.763 0.91 1.14943 TEAD3 - Transcriptional enhancer factor TEF-5 - Homo sapiens (Human) - TEAD3 gene Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. Indicus|evm.model.CM009513.1.95 O00294 TULP1_HUMAN 74.234 0.996344 1.00923 TULP1 - Tubby-related protein 1 - Homo sapiens (Human) - TULP1 gene Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. Indicus|evm.model.CM009513.1.96 Q13451 FKBP5_HUMAN 95.186 0.995633 1.00219 FKBP5 - Peptidyl-prolyl cis-trans isomerase FKBP5 - Homo sapiens (Human) - FKBP5 gene Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277). Indicus|evm.model.CM009513.1.97 Q5T9G4 ARM12_HUMAN 87.273 0.967552 0.997059 ARMC12 - Armadillo repeat-containing protein 12 - Homo sapiens (Human) - ARMC12 gene nucleus Indicus|evm.model.CM009513.1.98 Q6UWE3 COLL2_HUMAN 64.130 0.892157 1.02 CLPSL2 - Colipase-like protein 2 precursor - Homo sapiens (Human) - CLPSL2 gene response to food Indicus|evm.model.CM009513.1.99 A0JNQ7 COL_BOVIN 97.321 0.982301 1.00893 CLPS - Colipase precursor - Bos taurus (Bovine) - CLPS gene Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Indicus|evm.model.CM009513.1.100 Q5PPI7 LHPL5_RAT 98.624 0.780576 1.26941 Lhfpl5 - LHFPL tetraspan subfamily member 5 protein - Rattus norvegicus (Rat) - Lhfpl5 gene In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity). Indicus|evm.model.CM009513.1.101 Q96SB4 SRPK1_HUMAN 89.942 0.997089 1.04885 SRPK1 - SRSF protein kinase 1 - Homo sapiens (Human) - SRPK1 gene Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. Indicus|evm.model.CM009513.1.102 A6QNW6 S26A8_BOVIN 99.896 0.923003 1.08229 SLC26A8 - Testis anion transporter 1 - Bos taurus (Bovine) - SLC26A8 gene Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility (By similarity). Indicus|evm.model.CM009513.1.103 Q16539 MK14_HUMAN 100.000 0.99446 1.00278 MAPK14 - Mitogen-activated protein kinase 14 - Homo sapiens (Human) - MAPK14 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'. Indicus|evm.model.CM009513.1.104 Q3T0N5 MK13_BOVIN 99.727 0.99455 1.00273 MAPK13 - Mitogen-activated protein kinase 13 - Bos taurus (Bovine) - MAPK13 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells (By similarity). Indicus|evm.model.CM009513.1.105 Q9ULD4 BRPF3_HUMAN 94.283 0.998344 1.00249 BRPF3 - Bromodomain and PHD finger-containing protein 3 - Homo sapiens (Human) - BRPF3 gene Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Indicus|evm.model.CM009513.1.106 Q8N8W4 PLPL1_HUMAN 70.962 0.992982 1.07143 PNPLA1 - Omega-hydroxyceramide transacylase - Homo sapiens (Human) - PNPLA1 gene Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation (PubMed:27751867, PubMed:28248318). Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide (PubMed:27751867, PubMed:28248318). Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function (PubMed:22246504, PubMed:27751867, PubMed:28248318). These lipids also play a role in keratinocyte differentiation (By similarity). May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS) (By similarity). Indicus|evm.model.CM009513.1.107 P0C671 BNIP5_HUMAN 55.489 0.996732 0.93865 BNIP5 - Protein BNIP5 - Homo sapiens (Human) - BNIP5 gene Indicus|evm.model.CM009513.1.108 P09651 ROA1_HUMAN 98.095 0.753623 0.741935 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Homo sapiens (Human) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). Indicus|evm.model.CM009513.1.109 Q8NFP0 PXT1_HUMAN 72.180 0.970588 1.01493 PXT1 - Peroxisomal testis-specific protein 1 - Homo sapiens (Human) - PXT1 gene nucleus, peroxisome, positive regulation of apoptotic process Indicus|evm.model.CM009513.1.110 Q7Z5Y7 KCD20_HUMAN 93.556 0.995238 1.00239 KCTD20 - BTB/POZ domain-containing protein KCTD20 - Homo sapiens (Human) - KCTD20 gene Promotes the phosphorylation of AKT family members. Indicus|evm.model.CM009513.1.111 A2VDV2 STK38_BOVIN 99.140 0.995671 0.993548 STK38 - Serine/threonine-protein kinase 38 - Bos taurus (Bovine) - STK38 gene Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). Indicus|evm.model.CM009513.1.112 P61354 RL27_RAT 71.171 0.982143 0.823529 Rpl27 - 60S ribosomal protein L27 - Rattus norvegicus (Rat) - Rpl27 gene Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity). Indicus|evm.model.CM009513.1.113 P84104 SRSF3_MOUSE 100.000 0.987879 1.0061 Srsf3 - Serine/arginine-rich splicing factor 3 - Mus musculus (Mouse) - Srsf3 gene Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. RNA-binding is semi-sequence specific. Indicus|evm.model.CM009513.1.114 P79103 RS4_BOVIN 99.240 0.992424 1.0038 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009513.1.115 O19002 CDN1A_FELCA 85.366 0.737327 1.32317 CDKN1A - Cyclin-dependent kinase inhibitor 1 - Felis catus (Cat) - CDKN1A gene May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity). Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity). Indicus|evm.model.CM009513.1.116 Q96FH0 BORC8_HUMAN 94.643 0.808824 0.571429 BORCS8 - BLOC-1-related complex subunit 8 - Homo sapiens (Human) - BORCS8 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Indicus|evm.model.CM009513.1.117 Q7Z6P3 RAB44_HUMAN 80.175 0.375412 0.892262 RAB44 - Ras-related protein Rab-44 - Homo sapiens (Human) - RAB44 gene azurophil granule membrane, plasma membrane, specific granule membrane, neutrophil degranulation Indicus|evm.model.CM009513.1.119 Q9HCH3 CPNE5_HUMAN 95.574 0.996727 1.03035 CPNE5 - Copine-5 - Homo sapiens (Human) - CPNE5 gene Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Indicus|evm.model.CM009513.1.120 Q9Y3C6 PPIL1_HUMAN 100.000 0.988024 1.00602 PPIL1 - Peptidyl-prolyl cis-trans isomerase-like 1 - Homo sapiens (Human) - PPIL1 gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688). Indicus|evm.model.CM009513.1.121 Q5R9Q8 CF089_PONAB 84.770 0.994269 1.00576 Bombesin receptor-activated protein C6orf89 homolog - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009513.1.122 Q58D34 PI16_BOVIN 100.000 0.995699 1.00216 PI16 - Peptidase inhibitor 16 precursor - Bos taurus (Bovine) - PI16 gene May inhibit cardiomyocyte growth. Indicus|evm.model.CM009513.1.123 Q9NZJ7 MTCH1_HUMAN 99.278 0.992806 0.714653 MTCH1 - Mitochondrial carrier homolog 1 - Homo sapiens (Human) - MTCH1 gene Potential mitochondrial transporter. May play a role in apoptosis. Indicus|evm.model.CM009513.1.125 Q7Z6J4 FGD2_HUMAN 88.262 0.996956 1.00305 FGD2 - FYVE, RhoGEF and PH domain-containing protein 2 - Homo sapiens (Human) - FGD2 gene Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Indicus|evm.model.CM009513.1.126 Q9N0P9 PIM1_BOVIN 100.000 0.696429 1.43131 PIM1 - Serine/threonine-protein kinase pim-1 - Bos taurus (Bovine) - PIM1 gene Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 protein binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells. Promotes brown adipocyte differentiation (By similarity). Indicus|evm.model.CM009513.1.128 Q8N7C4 TM217_HUMAN 64.398 0.984456 0.842795 TMEM217 - Transmembrane protein 217 - Homo sapiens (Human) - TMEM217 gene Indicus|evm.model.CM009513.1.129 Q95LL3 TB22B_MACFA 98.812 0.996047 1.00198 TBC1D22B - TBC1 domain family member 22B - Macaca fascicularis (Crab-eating macaque) - TBC1D22B gene May act as a GTPase-activating protein for Rab family protein(s). Indicus|evm.model.CM009513.1.130 Q2HJ46 RNF8_BOVIN 99.795 0.995902 1.00205 RNF8 - E3 ubiquitin-protein ligase RNF8 - Bos taurus (Bovine) - RNF8 gene E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (By similarity). Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (By similarity). In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2 (By similarity). Indicus|evm.model.CM009513.1.131 A2VE39 CMTR1_BOVIN 100.000 0.684729 1.45868 CMTR1 - Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 - Bos taurus (Bovine) - CMTR1 gene S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. Indicus|evm.model.CM009513.1.132 A1A4P9 CC167_BOVIN 100.000 0.979592 1.01031 CCDC167 - Coiled-coil domain-containing protein 167 - Bos taurus (Bovine) - CCDC167 gene Indicus|evm.model.CM009513.1.134 Q8NFP4 MDGA1_HUMAN 97.192 0.997843 0.970681 MDGA1 - MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor - Homo sapiens (Human) - MDGA1 gene Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. Indicus|evm.model.CM009513.1.135 Q9H8U3 ZFAN3_HUMAN 97.797 0.991228 1.00441 ZFAND3 - AN1-type zinc finger protein 3 - Homo sapiens (Human) - ZFAND3 gene Indicus|evm.model.CM009513.1.137 A4IFG2 BTBD9_BOVIN 99.836 0.848401 1.17676 BTBD9 - BTB/POZ domain-containing protein 9 - Bos taurus (Bovine) - BTBD9 gene adult locomotory behavior, circadian behavior, modulation of chemical synaptic transmission Indicus|evm.model.CM009513.1.138 Q6P7Q4 LGUL_RAT 92.391 0.989189 1.00543 Glo1 - Lactoylglutathione lyase - Rattus norvegicus (Rat) - Glo1 gene Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Indicus|evm.model.CM009513.1.139 Q96JB1 DYH8_HUMAN 95.225 0.881462 0.999555 DNAH8 - Dynein axonemal heavy chain 8 - Homo sapiens (Human) - DNAH8 gene Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Indicus|evm.model.CM009513.1.140 Q32L85 SMDC1_BOVIN 98.454 0.989744 1.00515 SAYSD1 - SAYSvFN domain-containing protein 1 - Bos taurus (Bovine) - SAYSD1 gene Indicus|evm.model.CM009513.1.141 O95279 KCNK5_HUMAN 88.778 0.995984 0.997996 KCNK5 - Potassium channel subfamily K member 5 - Homo sapiens (Human) - KCNK5 gene pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations. Indicus|evm.model.CM009513.1.142 Q96T54 KCNKH_HUMAN 74.545 0.947368 1.03012 KCNK17 - Potassium channel subfamily K member 17 - Homo sapiens (Human) - KCNK17 gene Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Indicus|evm.model.CM009513.1.143 Q96T55 KCNKG_HUMAN 83.498 0.989831 0.954693 KCNK16 - Potassium channel subfamily K member 16 - Homo sapiens (Human) - KCNK16 gene Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Indicus|evm.model.CM009513.1.144 Q6ZMV9 KIF6_HUMAN 75.336 0.847107 0.297297 KIF6 - Kinesin-like protein KIF6 - Homo sapiens (Human) - KIF6 gene kinesin complex, microtubule, ATPase activity, microtubule binding, microtubule motor activity, microtubule-based movement Indicus|evm.model.CM009513.1.145 Q6ZMV9 KIF6_HUMAN 93.805 0.823529 0.167076 KIF6 - Kinesin-like protein KIF6 - Homo sapiens (Human) - KIF6 gene kinesin complex, microtubule, ATPase activity, microtubule binding, microtubule motor activity, microtubule-based movement Indicus|evm.model.CM009513.1.146 Q6ZMV9 KIF6_HUMAN 86.184 0.867816 0.213759 KIF6 - Kinesin-like protein KIF6 - Homo sapiens (Human) - KIF6 gene kinesin complex, microtubule, ATPase activity, microtubule binding, microtubule motor activity, microtubule-based movement Indicus|evm.model.CM009513.1.147 Q6ZMV9 KIF6_HUMAN 92.683 0.663934 0.149877 KIF6 - Kinesin-like protein KIF6 - Homo sapiens (Human) - KIF6 gene kinesin complex, microtubule, ATPase activity, microtubule binding, microtubule motor activity, microtubule-based movement Indicus|evm.model.CM009513.1.148 Q86T65 DAAM2_HUMAN 96.629 0.998127 1 DAAM2 - Disheveled-associated activator of morphogenesis 2 - Homo sapiens (Human) - DAAM2 gene Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Indicus|evm.model.CM009513.1.149 Q1JQD7 MOCS1_BOVIN 99.684 0.996845 1.00158 MOCS1 - Molybdenum cofactor biosynthesis protein 1 - Bos taurus (Bovine) - MOCS1 gene Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP. Indicus|evm.model.CM009513.1.151 Q9BE71 LRFN2_MACFA 90.683 0.993769 0.406844 LRFN2 - Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor - Macaca fascicularis (Crab-eating macaque) - LRFN2 gene Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity). Indicus|evm.model.CM009513.1.152 Q9ULH4 LRFN2_HUMAN 98.073 0.978992 0.603295 LRFN2 - Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor - Homo sapiens (Human) - LRFN2 gene Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity). Indicus|evm.model.CM009513.1.154 Q8IV45 UN5CL_HUMAN 87.259 0.996146 1.00193 UNC5CL - UNC5C-like protein - Homo sapiens (Human) - UNC5CL gene Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets. Indicus|evm.model.CM009513.1.155 E2RDM9 TSPO2_CANLF 54.217 0.96875 0.930233 TSPO2 - Translocator protein 2 - Canis lupus familiaris (Dog) - TSPO2 gene Cholesterol-binding protein involved in the redistribution of cholesterol from lipid droplets to the endoplasmic reticulum (PubMed:32358067). Required to meet cholesterol demands during erythropoietic differentiation (PubMed:32358067). May play a role in transport processes at the plasma membrane of erythrocytes, including regulating VDAC-mediated ATP export, and import of the heme precursors protoporphyrin IX and 5-aminolevulinic acid (By similarity). Indicus|evm.model.CM009513.1.156 Q3SYR3 ABEC2_BOVIN 100.000 0.991111 1.00446 APOBEC2 - Probable C->U-editing enzyme APOBEC-2 - Bos taurus (Bovine) - APOBEC2 gene Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Indicus|evm.model.CM009513.1.157 Q1LZ74 OARD1_BOVIN 100.000 0.986928 1.00658 OARD1 - ADP-ribose glycohydrolase OARD1 - Bos taurus (Bovine) - OARD1 gene ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively. Indicus|evm.model.CM009513.1.158 P23511 NFYA_HUMAN 91.066 0.99373 0.919308 NFYA - Nuclear transcription factor Y subunit alpha - Homo sapiens (Human) - NFYA gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. Indicus|evm.model.CM009513.1.160 Q86YW5 TRML1_HUMAN 65.781 0.949206 1.01286 TREML1 - Trem-like transcript 1 protein precursor - Homo sapiens (Human) - TREML1 gene Cell surface receptor that may play a role in the innate and adaptive immune response. Indicus|evm.model.CM009513.1.161 Q9NZC2 TREM2_HUMAN 80.000 0.991342 1.00435 TREM2 - Triggering receptor expressed on myeloid cells 2 precursor - Homo sapiens (Human) - TREM2 gene Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia (PubMed:27477018, PubMed:29518356). Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (By similarity). Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia (PubMed:27477018). Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin (PubMed:29794134). Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (By similarity). Required for microglial phagocytosis of apoptotic neurons (PubMed:24990881). Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (By similarity). Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (By similarity). It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (By similarity). During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (By similarity). Plays a role in microglial MTOR activation and metabolism (By similarity). Regulates age-related changes in microglial numbers (PubMed:29752066). Triggers activation of the immune responses in macrophages and dendritic cells (PubMed:10799849). Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). Involved in the positive regulation of osteoclast differentiation (PubMed:12925681). Indicus|evm.model.CM009513.1.162 Q5T2D2 TRML2_HUMAN 61.468 0.73913 1.36137 TREML2 - Trem-like transcript 2 protein precursor - Homo sapiens (Human) - TREML2 gene Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Indicus|evm.model.CM009513.1.163 Q6QUN5 TREM1_BOVIN 99.138 0.991416 1.00431 TREM1 - Triggering receptor expressed on myeloid cells 1 precursor - Bos taurus (Bovine) - TREM1 gene Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of proinflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis. Indicus|evm.model.CM009513.1.167 Q8IVH2 FOXP4_HUMAN 93.723 0.997033 0.991176 FOXP4 - Forkhead box protein P4 - Homo sapiens (Human) - FOXP4 gene Transcriptional repressor that represses lung-specific expression. Indicus|evm.model.CM009513.1.168 Q99750 MDFI_HUMAN 89.069 0.991935 1.00813 MDFI - MyoD family inhibitor - Homo sapiens (Human) - MDFI gene Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity). Indicus|evm.model.CM009513.1.169 P19484 TFEB_HUMAN 94.154 0.995825 1.0063 TFEB - Transcription factor EB - Homo sapiens (Human) - TFEB gene Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:30120233, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22576015, PubMed:22343943, PubMed:22692423). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus or S.enterica, acting downstream of protein kinase D (PKD), probably by regulating cytokine and chemokine expression (By similarity). Indicus|evm.model.CM009513.1.170 Q9GMY3 PEPC_RHIFE 84.365 0.701835 1.12082 PGC - Gastricsin precursor - Rhinolophus ferrumequinum (Greater horseshoe bat) - PGC gene Hydrolyzes a variety of proteins. Indicus|evm.model.CM009513.1.171 O43559 FRS3_HUMAN 93.737 0.995968 1.00813 FRS3 - Fibroblast growth factor receptor substrate 3 - Homo sapiens (Human) - FRS3 gene Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. Indicus|evm.model.CM009513.1.172 Q2TBC4 PRIC4_HUMAN 72.543 0.880102 1.13953 PRICKLE4 - Prickle-like protein 4 - Homo sapiens (Human) - PRICKLE4 gene adherens junction, filamentous actin, nucleus, stress fiber, Z disc, actin binding, muscle alpha-actinin binding, actin cytoskeleton organization, heart development, muscle structure development Indicus|evm.model.CM009513.1.173 Q56JY4 TOM6_BOVIN 95.556 0.611111 0.972973 TOMM6 - Mitochondrial import receptor subunit TOM6 homolog - Bos taurus (Bovine) - TOMM6 gene mitochondrion Indicus|evm.model.CM009513.1.174 Q70CQ1 UBP49_HUMAN 94.470 0.633041 0.994186 USP49 - Ubiquitin carboxyl-terminal hydrolase 49 - Homo sapiens (Human) - USP49 gene Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons. Indicus|evm.model.CM009513.1.175 Q9H944 MED20_HUMAN 98.529 0.860169 1.11321 MED20 - Mediator of RNA polymerase II transcription subunit 20 - Homo sapiens (Human) - MED20 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Indicus|evm.model.CM009513.1.176 Q5E9N0 BYST_BOVIN 99.770 0.995413 1.0023 BYSL - Bystin - Bos taurus (Bovine) - BYSL gene Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. Indicus|evm.model.CM009513.1.177 Q3MHH5 CCND3_BOVIN 99.658 0.993174 1.00342 CCND3 - G1/S-specific cyclin-D3 - Bos taurus (Bovine) - CCND3 gene Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). Indicus|evm.model.CM009513.1.178 A7MAZ4 TAF8_BOVIN 99.353 0.740385 1.34194 TAF8 - Transcription initiation factor TFIID subunit 8 - Bos taurus (Bovine) - TAF8 gene Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). Indicus|evm.model.CM009513.1.179 Q5T0Z8 CF132_HUMAN 67.575 0.311755 0.988215 C6orf132 - Uncharacterized protein C6orf132 - Homo sapiens (Human) - C6orf132 gene Indicus|evm.model.CM009513.1.180 X6R8D5 GUCNB_HUMAN 86.239 0.830769 1.02362 GUCA1ANB - Putative uncharacterized protein GUCA1ANB - Homo sapiens (Human) - GUCA1ANB gene Indicus|evm.model.CM009513.1.181 P46065 GUC1A_BOVIN 100.000 0.990291 1.00488 GUCA1A - Guanylyl cyclase-activating protein 1 - Bos taurus (Bovine) - GUCA1A gene Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:7520254, PubMed:8626484, PubMed:9651312, PubMed:26703466). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:7520254, PubMed:8626484). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity). Indicus|evm.model.CM009513.1.182 P51177 GUC1B_BOVIN 99.510 0.990244 1.0049 GUCA1B - Guanylyl cyclase-activating protein 2 - Bos taurus (Bovine) - GUCA1B gene Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (PubMed:7665624). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:9651312). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). Indicus|evm.model.CM009513.1.183 P82670 RT10_BOVIN 100.000 0.990099 1.00498 MRPS10 - 28S ribosomal protein S10, mitochondrial - Bos taurus (Bovine) - MRPS10 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion Indicus|evm.model.CM009513.1.184 Q96PN7 TREF1_HUMAN 87.469 0.998347 1.00833 TRERF1 - Transcriptional-regulating factor 1 - Homo sapiens (Human) - TRERF1 gene Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. Indicus|evm.model.CM009513.1.186 Q8IWV8 UBR2_HUMAN 92.426 0.998862 1.00114 UBR2 - E3 ubiquitin-protein ligase UBR2 - Homo sapiens (Human) - UBR2 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:20835242). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (By similarity). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity). Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis (By similarity). Indicus|evm.model.CM009513.1.187 P17810 PRPH2_BOVIN 99.711 0.994236 1.00289 PRPH2 - Peripherin-2 - Bos taurus (Bovine) - PRPH2 gene Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (PubMed:24196967). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Indicus|evm.model.CM009513.1.188 Q3SZE9 TBCC_BOVIN 100.000 0.99422 1.0029 TBCC - Tubulin-specific chaperone C - Bos taurus (Bovine) - TBCC gene Tubulin-folding protein; involved in the final step of the tubulin folding pathway. Indicus|evm.model.CM009513.1.189 Q6AI39 BICRL_HUMAN 92.315 0.987025 1 BICRAL - BRD4-interacting chromatin-remodeling complex-associated protein-like - Homo sapiens (Human) - BICRAL gene Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Indicus|evm.model.CM009513.1.190 A5GFQ0 RL7L_PIG 92.713 0.957198 1.04049 RPL7L1 - 60S ribosomal protein L7-like 1 - Sus scrofa (Pig) - RPL7L1 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009513.1.191 Q9D727 CF226_MOUSE 66.667 0.517544 1 Uncharacterized protein C6orf226 homolog - Mus musculus (Mouse) Indicus|evm.model.CM009513.1.192 Q0P5N1 CNPY3_BOVIN 97.034 0.456863 1.80851 CNPY3 - Protein canopy homolog 3 precursor - Bos taurus (Bovine) - CNPY3 gene Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Indicus|evm.model.CM009513.1.193 Q14749 GNMT_HUMAN 92.857 0.936102 1.06102 GNMT - Glycine N-methyltransferase - Homo sapiens (Human) - GNMT gene Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. Indicus|evm.model.CM009513.1.194 Q13608 PEX6_HUMAN 91.224 0.997961 1.00102 PEX6 - Peroxisome assembly factor 2 - Homo sapiens (Human) - PEX6 gene Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Indicus|evm.model.CM009513.1.195 Q28653 2A5D_RABIT 99.141 0.963394 1.0256 PPP2R5D - Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform - Oryctolagus cuniculus (Rabbit) - PPP2R5D gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Indicus|evm.model.CM009513.1.196 Q29407 MEA1_BOVIN 100.000 0.988571 1.00575 MEA1 - Male-enhanced antigen 1 - Bos taurus (Bovine) - MEA1 gene May play an important role in spermatogenesis and/or testis development. Indicus|evm.model.CM009513.1.197 Q58CV6 KLDC3_BOVIN 100.000 0.994778 1.00262 KLHDC3 - Kelch domain-containing protein 3 - Bos taurus (Bovine) - KLHDC3 gene May be involved in meiotic recombination process. Indicus|evm.model.CM009513.1.198 A6QNR1 RRP36_BOVIN 99.187 0.991903 1.00407 RRP36 - Ribosomal RNA processing protein 36 homolog - Bos taurus (Bovine) - RRP36 gene Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Indicus|evm.model.CM009513.1.199 Q14999 CUL7_HUMAN 86.425 0.998824 1.00118 CUL7 - Cullin-7 - Homo sapiens (Human) - CUL7 gene Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions. Indicus|evm.model.CM009513.1.200 Q2TA12 RM02_BOVIN 100.000 0.993485 1.00327 MRPL2 - 39S ribosomal protein L2, mitochondrial precursor - Bos taurus (Bovine) - MRPL2 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, RNA binding, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009513.1.201 Q2HJJ0 KLC4_BOVIN 94.050 0.977625 0.943182 KLC4 - Kinesin light chain 4 - Bos taurus (Bovine) - KLC4 gene Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). Indicus|evm.model.CM009513.1.202 Q13308 PTK7_HUMAN 94.112 0.998133 1.00093 PTK7 - Inactive tyrosine-protein kinase 7 precursor - Homo sapiens (Human) - PTK7 gene Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Indicus|evm.model.CM009513.1.203 P11831 SRF_HUMAN 97.839 0.996078 1.00394 SRF - Serum response factor - Homo sapiens (Human) - SRF gene SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. Indicus|evm.model.CM009513.1.204 Q8IWT3 CUL9_HUMAN 88.619 0.994045 1.00079 CUL9 - Cullin-9 - Homo sapiens (Human) - CUL9 gene Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328). Indicus|evm.model.CM009513.1.205 O43598 DNPH1_HUMAN 84.713 0.934132 0.95977 DNPH1 - 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 - Homo sapiens (Human) - DNPH1 gene Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. Indicus|evm.model.CM009513.1.206 Q6PCN3 TTBK1_MOUSE 94.181 0.515695 0.681957 Ttbk1 - Tau-tubulin kinase 1 - Mus musculus (Mouse) - Ttbk1 gene Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (By similarity). Indicus|evm.model.CM009513.1.207 A6QLW8 S22A7_BOVIN 99.817 0.99635 1.00183 SLC22A7 - Solute carrier family 22 member 7 - Bos taurus (Bovine) - SLC22A7 gene Mediates sodium-independent multispecific organic anion transport. Indicus|evm.model.CM009513.1.208 Q6Q6R5 CRIP3_HUMAN 92.432 0.897561 0.9447 CRIP3 - Cysteine-rich protein 3 - Homo sapiens (Human) - CRIP3 gene Indicus|evm.model.CM009513.1.209 Q5VUA4 ZN318_HUMAN 83.128 0.991736 0.955682 ZNF318 - Zinc finger protein 318 - Homo sapiens (Human) - ZNF318 gene Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. Indicus|evm.model.CM009513.1.210 Q5T3U5 MRP7_HUMAN 89.725 0.963107 1.03552 ABCC10 - ATP-binding cassette sub-family C member 10 - Homo sapiens (Human) - ABCC10 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:12527806, PubMed:15256465). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel (PubMed:15256465, PubMed:23087055). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP (PubMed:12527806). Indicus|evm.model.CM009513.1.211 A4FV93 DLK2_BOVIN 99.478 0.994792 1.00261 DLK2 - Protein delta homolog 2 precursor - Bos taurus (Bovine) - DLK2 gene Regulates adipogenesis. Indicus|evm.model.CM009513.1.212 Q5JTD0 TJAP1_HUMAN 89.088 0.835115 1.17594 TJAP1 - Tight junction-associated protein 1 - Homo sapiens (Human) - TJAP1 gene Plays a role in regulating the structure of the Golgi apparatus. Indicus|evm.model.CM009513.1.213 Q5JTD7 LRC73_HUMAN 98.101 0.993691 1.00316 LRRC73 - Leucine-rich repeat-containing protein 73 - Homo sapiens (Human) - LRRC73 gene Indicus|evm.model.CM009513.1.214 Q9GZM5 YIPF3_HUMAN 97.429 0.994253 0.994286 YIPF3 - Protein YIPF3 - Homo sapiens (Human) - YIPF3 gene Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis. Indicus|evm.model.CM009513.1.215 Q32L22 RPAC1_BOVIN 99.711 0.994236 1.00289 POLR1C - DNA-directed RNA polymerases I and III subunit RPAC1 - Bos taurus (Bovine) - POLR1C gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Indicus|evm.model.CM009513.1.216 Q9HAV4 XPO5_HUMAN 94.212 0.998213 0.929402 XPO5 - Exportin-5 - Homo sapiens (Human) - XPO5 gene Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner. Indicus|evm.model.CM009513.1.217 Q9Y253 POLH_HUMAN 82.889 0.997191 0.998597 POLH - DNA polymerase eta - Homo sapiens (Human) - POLH gene DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906, PubMed:24553286, PubMed:16357261). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). Indicus|evm.model.CM009513.1.218 Q9BX10 GTPB2_HUMAN 98.505 0.996683 1.00166 GTPBP2 - GTP-binding protein 2 - Homo sapiens (Human) - GTPBP2 gene extracellular region, platelet alpha granule lumen, identical protein binding, translation elongation factor activity, platelet degranulation, translational elongation Indicus|evm.model.CM009513.1.219 Q15013 MD2BP_HUMAN 86.131 0.964664 1.03285 MAD2L1BP - MAD2L1-binding protein - Homo sapiens (Human) - MAD2L1BP gene May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. Indicus|evm.model.CM009513.1.220 Q2KIU7 RSPH9_BOVIN 100.000 0.99278 1.00362 RSPH9 - Radial spoke head protein 9 homolog - Bos taurus (Bovine) - RSPH9 gene Component of the axonemal radial spoke head which plays an important role in ciliary motility (By similarity). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (By similarity). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (By similarity). Indicus|evm.model.CM009513.1.221 P82919 RT18A_BOVIN 99.490 0.989848 1.0051 MRPS18A - 28S ribosomal protein S18a, mitochondrial precursor - Bos taurus (Bovine) - MRPS18A gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit rRNA binding, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009513.1.223 P15691 VEGFA_BOVIN 98.701 0.684685 0.584211 VEGFA - Vascular endothelial growth factor A precursor - Bos taurus (Bovine) - VEGFA gene Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Indicus|evm.model.CM009513.1.224 Q9MYV3 VEGFA_CANLF 94.495 0.981818 0.514019 VEGFA - Vascular endothelial growth factor A precursor - Canis lupus familiaris (Dog) - VEGFA gene Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Indicus|evm.model.CM009513.1.225 Q4R642 DRC5_MACFA 76.531 0.764706 0.508982 TCTE1 - Dynein regulatory complex subunit 5 - Macaca fascicularis (Crab-eating macaque) - TCTE1 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility. Indicus|evm.model.CM009513.1.226 Q14CH7 SYAM_MOUSE 87.342 0.962963 0.0826531 Aars2 - Alanine--tRNA ligase, mitochondrial precursor - Mus musculus (Mouse) - Aars2 gene Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Indicus|evm.model.CM009513.1.227 Q1JQ99 RM14_BOVIN 100.000 0.986301 1.0069 MRPL14 - 39S ribosomal protein L14, mitochondrial precursor - Bos taurus (Bovine) - MRPL14 gene May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation. Indicus|evm.model.CM009513.1.228 Q5T3F8 CSCL2_HUMAN 97.957 0.937783 1.0625 TMEM63B - CSC1-like protein 2 - Homo sapiens (Human) - TMEM63B gene Acts as an osmosensitive calcium-permeable cation channel (By similarity). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (By similarity). Indicus|evm.model.CM009513.1.229 Q9UMQ6 CAN11_HUMAN 79.743 0.925631 1.01894 CAPN11 - Calpain-11 - Homo sapiens (Human) - CAPN11 gene Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Indicus|evm.model.CM009513.1.230 A0A1B0GTQ4 MYMX_HUMAN 87.500 0.741176 1.0119 MYMX - Protein myomixer - Homo sapiens (Human) - MYMX gene Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK. Acts by generating membrane stresses via its extracellular C-terminus, leading to drive fusion pore formation. Acts independently of MYMK. Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers. Indicus|evm.model.CM009513.1.231 Q99808 S29A1_HUMAN 86.842 0.837937 1.19079 SLC29A1 - Equilibrative nucleoside transporter 1 - Homo sapiens (Human) - SLC29A1 gene Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). Indicus|evm.model.CM009513.1.232 P46633 HS90A_CRIGR 71.760 0.957971 0.941337 HSP90AA1 - Heat shock protein HSP 90-alpha - Cricetulus griseus (Chinese hamster) - HSP90AA1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response. Indicus|evm.model.CM009513.1.233 Q8TB61 S35B2_HUMAN 93.764 0.995392 1.00463 SLC35B2 - Adenosine 3'-phospho 5'-phosphosulfate transporter 1 - Homo sapiens (Human) - SLC35B2 gene Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Indicus|evm.model.CM009513.1.234 O00221 IKBE_HUMAN 87.845 0.99449 0.726 NFKBIE - NF-kappa-B inhibitor epsilon - Homo sapiens (Human) - NFKBIE gene Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Indicus|evm.model.CM009513.1.235 Q8IW70 T151B_HUMAN 97.913 0.583796 1.59187 TMEM151B - Transmembrane protein 151B - Homo sapiens (Human) - TMEM151B gene Indicus|evm.model.CM009513.1.237 O75486 SUPT3_HUMAN 77.901 0.940104 1.21136 SUPT3H - Transcription initiation protein SPT3 homolog - Homo sapiens (Human) - SUPT3H gene Probable transcriptional activator. Indicus|evm.model.CM009513.1.238 Q9Z2J9 RUNX2_RAT 100.000 0.304945 1.66972 Runx2 - Runt-related transcription factor 2 - Rattus norvegicus (Rat) - Runx2 gene Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Indicus|evm.model.CM009513.1.240 P35526 CLIC5_BOVIN 99.163 0.940711 0.578947 CLIC5 - Chloride intracellular channel protein 5 - Bos taurus (Bovine) - CLIC5 gene Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Indicus|evm.model.CM009513.1.241 P35526 CLIC5_BOVIN 96.618 0.927928 0.508009 CLIC5 - Chloride intracellular channel protein 5 - Bos taurus (Bovine) - CLIC5 gene Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Indicus|evm.model.CM009513.1.242 A2VDP5 ENPP4_BOVIN 99.779 0.995595 1.00221 ENPP4 - Bis(5'-adenosyl)-triphosphatase ENPP4 precursor - Bos taurus (Bovine) - ENPP4 gene Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors (By similarity). Indicus|evm.model.CM009513.1.243 Q9UJA9 ENPP5_HUMAN 85.535 0.995816 1.0021 ENPP5 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 precursor - Homo sapiens (Human) - ENPP5 gene Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication. Indicus|evm.model.CM009513.1.244 Q3ZC15 RCAN2_BOVIN 100.000 0.989899 1.00508 RCAN2 - Calcipressin-2 - Bos taurus (Bovine) - RCAN2 gene Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity). Indicus|evm.model.CM009513.1.245 Q9NYL5 CP39A_HUMAN 79.701 0.993617 1.00213 CYP39A1 - 24-hydroxycholesterol 7-alpha-hydroxylase precursor - Homo sapiens (Human) - CYP39A1 gene A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis (PubMed:25201972, PubMed:10748047). Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:25201972, PubMed:10748047). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25201972, PubMed:10748047). Indicus|evm.model.CM009513.1.246 O95847 UCP4_HUMAN 94.737 0.993827 1.0031 SLC25A27 - Mitochondrial uncoupling protein 4 - Homo sapiens (Human) - SLC25A27 gene UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain. Indicus|evm.model.CM009513.1.247 O60522 TDRD6_HUMAN 76.283 0.999044 0.998569 TDRD6 - Tudor domain-containing protein 6 - Homo sapiens (Human) - TDRD6 gene Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (By similarity). Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein) (By similarity). Indicus|evm.model.CM009513.1.248 Q28017 PAFA_BOVIN 99.550 0.995506 1.00225 PLA2G7 - Platelet-activating factor acetylhydrolase precursor - Bos taurus (Bovine) - PLA2G7 gene Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (By similarity). At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (By similarity). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (By similarity). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent proinflammatory signaling lipid that acts through PTAFR on various innate immune cells (By similarity). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled proinflammatory effects (By similarity). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (By similarity). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (By similarity). Indicus|evm.model.CM009513.1.249 B4E2M5 ANR66_HUMAN 81.538 0.979798 0.788845 ANKRD66 - Ankyrin repeat domain-containing protein 66 - Homo sapiens (Human) - ANKRD66 gene Indicus|evm.model.CM009513.1.250 Q16819 MEP1A_HUMAN 82.911 0.997333 1.00536 MEP1A - Meprin A subunit alpha precursor - Homo sapiens (Human) - MEP1A gene extracellular exosome, extracellular space, integral component of plasma membrane, meprin A complex, metalloendopeptidase activity Indicus|evm.model.CM009513.1.251 Q8IZF2 AGRF5_HUMAN 72.376 0.987717 1.02823 ADGRF5 - Adhesion G protein-coupled receptor F5 precursor - Homo sapiens (Human) - ADGRF5 gene Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function. Indicus|evm.model.CM009513.1.252 Q5T601 AGRF1_HUMAN 69.408 0.952681 1.04505 ADGRF1 - Adhesion G-protein coupled receptor F1 precursor - Homo sapiens (Human) - ADGRF1 gene Orphan receptor. Indicus|evm.model.CM009513.1.253 Q5R8S7 PPIA_PONPY 81.034 0.857143 0.806061 PPIA - Peptidyl-prolyl cis-trans isomerase A - Pongo pygmaeus (Bornean orangutan) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009513.1.254 O75509 TNR21_HUMAN 90.687 0.996937 0.996947 TNFRSF21 - Tumor necrosis factor receptor superfamily member 21 precursor - Homo sapiens (Human) - TNFRSF21 gene Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Indicus|evm.model.CM009513.1.255 Q9Y5K6 CD2AP_HUMAN 86.936 0.996865 0.998435 CD2AP - CD2-associated protein - Homo sapiens (Human) - CD2AP gene Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). Indicus|evm.model.CM009513.1.256 Q8IZF7 AGRF2_HUMAN 79.856 0.801449 0.974576 ADGRF2 - Adhesion G-protein coupled receptor F2 - Homo sapiens (Human) - ADGRF2 gene Orphan receptor. Indicus|evm.model.CM009513.1.257 Q8IZF3 AGRF4_HUMAN 80.897 0.99711 0.995683 ADGRF4 - Adhesion G protein-coupled receptor F4 precursor - Homo sapiens (Human) - ADGRF4 gene Orphan receptor. Indicus|evm.model.CM009513.1.258 Q6U736 OPN5_HUMAN 94.163 0.850498 0.850282 OPN5 - Opsin-5 - Homo sapiens (Human) - OPN5 gene G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (By similarity). Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed:22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (By similarity). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (By similarity). Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (By similarity). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (By similarity). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (By similarity). Indicus|evm.model.CM009513.1.259 Q6ZW05 PTHD4_HUMAN 98.039 0.996086 0.604019 PTCHD4 - Patched domain-containing protein 4 - Homo sapiens (Human) - PTCHD4 gene Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells. Indicus|evm.model.CM009513.1.260 Q6ZW05 PTHD4_HUMAN 96.296 0.952663 0.199764 PTCHD4 - Patched domain-containing protein 4 - Homo sapiens (Human) - PTCHD4 gene Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells. Indicus|evm.model.CM009513.1.261 Q6ZW05 PTHD4_HUMAN 98.400 0.610837 0.239953 PTCHD4 - Patched domain-containing protein 4 - Homo sapiens (Human) - PTCHD4 gene Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells. Indicus|evm.model.CM009513.1.262 Q58DB0 PLD3B_BOVIN 97.196 0.773723 0.706186 PRELID3B - PRELI domain containing protein 3B - Bos taurus (Bovine) - PRELID3B gene mitochondrial intermembrane space, phosphatidic acid transfer activity, phospholipid transport Indicus|evm.model.CM009513.1.263 Q9GK13 MUTA_BOVIN 98.133 0.997337 1.00133 MMUT - Methylmalonyl-CoA mutase, mitochondrial precursor - Bos taurus (Bovine) - MMUT gene Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. Indicus|evm.model.CM009513.1.264 Q7L2Z9 CENPQ_HUMAN 73.704 0.992593 1.00746 CENPQ - Centromere protein Q - Homo sapiens (Human) - CENPQ gene Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). Indicus|evm.model.CM009513.1.265 Q5SZD4 GLYL3_HUMAN 82.230 0.989583 1 GLYATL3 - Glycine N-acyltransferase-like protein 3 - Homo sapiens (Human) - GLYATL3 gene Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway. Indicus|evm.model.CM009513.1.266 Q5SZD1 CF141_HUMAN 56.219 0.989418 0.77459 C6orf141 - Uncharacterized protein C6orf141 - Homo sapiens (Human) - C6orf141 gene blastocyst hatching Indicus|evm.model.CM009513.1.268 Q9GKN7 RHAG_BOVIN 99.061 0.995316 1.00235 RHAG - Ammonium transporter Rh type A - Bos taurus (Bovine) - RHAG gene May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act as a monovalent cation transport. Indicus|evm.model.CM009513.1.269 P16562 CRIS2_HUMAN 81.557 0.991837 1.00823 CRISP2 - Cysteine-rich secretory protein 2 precursor - Homo sapiens (Human) - CRISP2 gene May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. Indicus|evm.model.CM009513.1.270 O19010 CRIS3_HORSE 70.588 0.584158 0.82449 CRISP3 - Cysteine-rich secretory protein 3 precursor - Equus caballus (Horse) - CRISP3 gene extracellular region, extracellular space, specific granule, cell-cell adhesion, fertilization, spermatogenesis Indicus|evm.model.CM009513.1.271 P68105 EF1A1_RABIT 96.104 0.99568 1.00216 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009513.1.272 Q8MIF7 PGK2_HORSE 93.285 0.995215 1.0024 PGK2 - Phosphoglycerate kinase 2 - Equus caballus (Horse) - PGK2 gene Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis. Indicus|evm.model.CM009513.1.273 P54107 CRIS1_HUMAN 64.246 0.838095 0.843373 CRISP1 - Cysteine-rich secretory protein 1 precursor - Homo sapiens (Human) - CRISP1 gene May have a role in sperm-egg fusion and maturation. Indicus|evm.model.CM009513.1.274 Q30KL5 DB112_PANTR 47.561 0.663934 1.07965 DEFB112 - Beta-defensin 112 precursor - Pan troglodytes (Chimpanzee) - DEFB112 gene Has antibacterial activity. Indicus|evm.model.CM009513.1.275 Q7Z6R9 AP2D_HUMAN 81.195 0.994609 0.820796 TFAP2D - Transcription factor AP-2-delta - Homo sapiens (Human) - TFAP2D gene Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). Indicus|evm.model.CM009513.1.276 Q92481 AP2B_HUMAN 100.000 0.995556 0.978261 TFAP2B - Transcription factor AP-2-beta - Homo sapiens (Human) - TFAP2B gene Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Indicus|evm.model.CM009513.1.277 E2RK30 PKHD1_CANLF 80.119 0.407606 1.00687 PKHD1 - Fibrocystin precursor - Canis lupus familiaris (Dog) - PKHD1 gene Promotes ciliogenesis in renal epithelial cells and therefore participates in the tubules formation and/ or ensures the maintenance of the architecture of the lumen of the kidney (By similarity). Has an impact on cellular symmetry by ensuring correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly and by maintaining oriented cell division (OCD) during tubular elongation through planar cell polarity (PCP) pathway (By similarity). During epithelial cell morphogenesis regulates also cell-cell and cell-matrix adhesion and participates in cell motility (PubMed:32698519, PubMed:31398719). Promotes cell-cell contact through the positive regulation of PTK2 kinase activity leading to either positive regulation of epithelial cell proliferation through the HRAS/RAF1 pathways, or negative regulation of apoptosis through the PDK1/AKT1 pathway (By similarity). May act in collecting-duct and biliary differentiation (By similarity). May participate in the regulation of the cholangiocytes proliferation and the CCN2 production in an CXCL8-dependent manner (By similarity). Indicus|evm.model.CM009513.1.278 Q6WV90 H4_MYTGA 99.029 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009513.1.279 Q687Y7 IL17_BOVIN 100.000 0.987013 1.00654 IL17A - Interleukin-17A precursor - Bos taurus (Bovine) - IL17A gene Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines. In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance. Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation. Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis. As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release. In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung. Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense. Indicus|evm.model.CM009513.1.280 Q7TNI7 IL17F_MOUSE 64.474 0.853801 1.06211 Il17f - Interleukin-17F precursor - Mus musculus (Mouse) - Il17f gene Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:23255360, PubMed:18025225, PubMed:19144317). IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:17911633, PubMed:15477493, PubMed:18025225). IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (PubMed:18025225, PubMed:23255360). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:18025225). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:28813677). Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (PubMed:28813677). Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (PubMed:32076265). Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (PubMed:29915298). Indicus|evm.model.CM009513.1.281 A4FUD9 MCM3_BOVIN 99.629 0.997528 1.00124 MCM3 - DNA replication licensing factor MCM3 - Bos taurus (Bovine) - MCM3 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation (By similarity). Indicus|evm.model.CM009513.1.282 O46415 FRIL_BOVIN 68.333 0.982456 0.651429 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009513.1.283 Q8K003 TMA7_MOUSE 98.438 0.7875 1.25 Tma7 - Translation machinery-associated protein 7 - Mus musculus (Mouse) - Tma7 gene cytoplasmic translation Indicus|evm.model.CM009513.1.284 Q865K9 MPRB_PIG 90.960 0.994366 1.00282 PAQR8 - Membrane progestin receptor beta - Sus scrofa (Pig) - PAQR8 gene Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity). Indicus|evm.model.CM009513.1.285 Q5JVL4 EFHC1_HUMAN 89.688 0.99688 1.00156 EFHC1 - EF-hand domain-containing protein 1 - Homo sapiens (Human) - EFHC1 gene Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization (PubMed:19734894, PubMed:28370826). Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142). May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581). Indicus|evm.model.CM009513.1.286 Q15035 TRAM2_HUMAN 95.405 0.994609 1.0027 TRAM2 - Translocating chain-associated membrane protein 2 - Homo sapiens (Human) - TRAM2 gene Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293). Indicus|evm.model.CM009513.1.288 P56982 TM14A_BOVIN 98.990 0.98 1.0101 TMEM14A - Transmembrane protein 14A - Bos taurus (Bovine) - TMEM14A gene Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Indicus|evm.model.CM009513.1.289 O18879 GSTA2_BOVIN 100.000 0.991071 1.00448 GSTA2 - Glutathione S-transferase A2 - Bos taurus (Bovine) - GSTA2 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Indicus|evm.model.CM009513.1.290 Q28035 GSTA1_BOVIN 88.406 0.990291 0.927928 GSTA1 - Glutathione S-transferase A1 - Bos taurus (Bovine) - GSTA1 gene Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid. Indicus|evm.model.CM009513.1.291 Q28035 GSTA1_BOVIN 100.000 0.991031 1.0045 GSTA1 - Glutathione S-transferase A1 - Bos taurus (Bovine) - GSTA1 gene Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid. Indicus|evm.model.CM009513.1.292 O18879 GSTA2_BOVIN 86.957 0.980952 0.941704 GSTA2 - Glutathione S-transferase A2 - Bos taurus (Bovine) - GSTA2 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Indicus|evm.model.CM009513.1.293 P24472 GSTA4_MOUSE 84.234 0.824627 1.20721 Gsta4 - Glutathione S-transferase A4 - Mus musculus (Mouse) - Gsta4 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Indicus|evm.model.CM009513.1.294 Q5E9G0 GSTA4_BOVIN 100.000 0.991031 1.0045 GSTA4 - Glutathione S-transferase A4 - Bos taurus (Bovine) - GSTA4 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Indicus|evm.model.CM009513.1.295 Q9UPZ9 CILK1_HUMAN 91.456 0.99682 0.995253 CILK1 - Serine/threonine-protein kinase ICK - Homo sapiens (Human) - CILK1 gene Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity). Indicus|evm.model.CM009513.1.297 Q3ZBT2 FBX9_BOVIN 99.544 0.995455 1.00686 FBXO9 - F-box only protein 9 - Bos taurus (Bovine) - FBXO9 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity). Indicus|evm.model.CM009513.1.298 Q9NP62 GCM1_HUMAN 74.312 0.995392 0.995413 GCM1 - Chorion-specific transcription factor GCMa - Homo sapiens (Human) - GCM1 gene Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). Indicus|evm.model.CM009513.1.299 Q2KJD9 ELOV5_BOVIN 100.000 0.993333 1.00334 ELOVL5 - Elongation of very long chain fatty acids protein 5 - Bos taurus (Bovine) - ELOVL5 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity). Indicus|evm.model.CM009513.1.300 P01909 DQA1_HUMAN 65.455 0.900826 0.476378 HLA-DQA1 - HLA class II histocompatibility antigen, DQ alpha 1 chain precursor - Homo sapiens (Human) - HLA-DQA1 gene Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. Indicus|evm.model.CM009513.1.301 P15981 HA2D_PIG 83.158 0.61039 0.603922 SLA class II histocompatibility antigen, DQ haplotype D alpha chain precursor - Sus scrofa (Pig) Indicus|evm.model.CM009513.1.302 Q9TVC8 HB21_BOVIN 88.660 0.461538 0.796935 BoLA-DQB - BoLa class II histocompatibility antigen, DQB*0101 beta chain precursor - Bos taurus (Bovine) - BoLA-DQB gene Indicus|evm.model.CM009513.1.303 P15981 HA2D_PIG 81.569 0.992188 1.00392 SLA class II histocompatibility antigen, DQ haplotype D alpha chain precursor - Sus scrofa (Pig) Indicus|evm.model.CM009513.1.304 P18470 HB2D_CANLF 80.682 0.419458 2.35714 DLA class II histocompatibility antigen, DR-1 beta chain precursor - Canis lupus familiaris (Dog) Indicus|evm.model.CM009513.1.305 P18470 HB2D_CANLF 76.768 0.255875 1.43985 DLA class II histocompatibility antigen, DR-1 beta chain precursor - Canis lupus familiaris (Dog) Indicus|evm.model.CM009513.1.306 Q30631 DRA_MACMU 80.709 0.992126 1 Mamu-DRA - Mamu class II histocompatibility antigen, DR alpha chain precursor - Macaca mulatta (Rhesus macaque) - Mamu-DRA gene Indicus|evm.model.CM009513.1.307 Q9UIR0 BTNL2_HUMAN 71.359 0.850427 1.02857 BTNL2 - Butyrophilin-like protein 2 - Homo sapiens (Human) - BTNL2 gene Negative regulator of T-cell proliferation. Indicus|evm.model.CM009513.1.309 Q7TST0 BTNL1_MOUSE 55.063 0.993534 0.911591 Btnl1 - Butyrophilin-like protein 1 precursor - Mus musculus (Mouse) - Btnl1 gene cell surface, external side of plasma membrane, signaling receptor binding, extrathymic T cell selection, regulation of cytokine production, T cell receptor signaling pathway Indicus|evm.model.CM009513.1.311 Q9TVC8 HB21_BOVIN 90.805 0.992366 1.00383 BoLA-DQB - BoLa class II histocompatibility antigen, DQB*0101 beta chain precursor - Bos taurus (Bovine) - BoLA-DQB gene Indicus|evm.model.CM009513.1.312 Q9UIR0 BTNL2_HUMAN 61.266 0.655678 1.2 BTNL2 - Butyrophilin-like protein 2 - Homo sapiens (Human) - BTNL2 gene Negative regulator of T-cell proliferation. Indicus|evm.model.CM009513.1.314 P18892 BT1A1_BOVIN 53.039 0.614334 0.557034 BTN1A1 - Butyrophilin subfamily 1 member A1 precursor - Bos taurus (Bovine) - BTN1A1 gene May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Indicus|evm.model.CM009513.1.315 Q5SRN2 TSBP1_HUMAN 49.754 0.353765 1.01421 TSBP1 - Testis-expressed basic protein 1 - Homo sapiens (Human) - TSBP1 gene nucleus Indicus|evm.model.CM009513.1.319 P18892 BT1A1_BOVIN 56.522 0.844444 0.256654 BTN1A1 - Butyrophilin subfamily 1 member A1 precursor - Bos taurus (Bovine) - BTN1A1 gene May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Indicus|evm.model.CM009513.1.320 Q99466 NOTC4_HUMAN 86.021 0.998995 0.99351 NOTCH4 - Neurogenic locus notch homolog protein 4 precursor - Homo sapiens (Human) - NOTCH4 gene Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). Indicus|evm.model.CM009513.1.321 Q9Y4H4 GPSM3_HUMAN 90.123 0.98773 1.01875 GPSM3 - G-protein-signaling modulator 3 - Homo sapiens (Human) - GPSM3 gene Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins. Indicus|evm.model.CM009513.1.322 P40425 PBX2_HUMAN 99.302 0.99536 1.00233 PBX2 - Pre-B-cell leukemia transcription factor 2 - Homo sapiens (Human) - PBX2 gene Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. Indicus|evm.model.CM009513.1.323 Q28173 RAGE_BOVIN 99.494 0.992443 0.954327 AGER - Advanced glycosylation end product-specific receptor precursor - Bos taurus (Bovine) - AGER gene Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Indicus|evm.model.CM009513.1.324 Q99942 RNF5_HUMAN 98.889 0.98895 1.00556 RNF5 - E3 ubiquitin-protein ligase RNF5 - Homo sapiens (Human) - RNF5 gene Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. Indicus|evm.model.CM009513.1.325 Q95JH2 PLCA_BOVIN 100.000 0.993056 1.00348 AGPAT1 - 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha precursor - Bos taurus (Bovine) - AGPAT1 gene Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Indicus|evm.model.CM009513.1.326 A5A8Y8 EGFL8_PIG 90.508 0.993243 1.00339 EGFL8 - Epidermal growth factor-like protein 8 precursor - Sus scrofa (Pig) - EGFL8 gene cell surface, extracellular region, signaling receptor binding, anatomical structure development Indicus|evm.model.CM009513.1.327 Q1JQA0 PPT2_BOVIN 100.000 0.974359 1.02295 PPT2 - Lysosomal thioesterase PPT2 precursor - Bos taurus (Bovine) - PPT2 gene Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). Indicus|evm.model.CM009513.1.328 Q99946 PRRT1_HUMAN 82.857 0.994286 1.14379 PRRT1 - Proline-rich transmembrane protein 1 - Homo sapiens (Human) - PRRT1 gene Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression. Indicus|evm.model.CM009513.1.329 Q9UIM3 FKBPL_HUMAN 83.668 0.891192 1.10602 FKBPL - FK506-binding protein-like - Homo sapiens (Human) - FKBPL gene May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. Indicus|evm.model.CM009513.1.330 Q99941 ATF6B_HUMAN 85.915 0.997175 1.00711 ATF6B - Cyclic AMP-dependent transcription factor ATF-6 beta - Homo sapiens (Human) - ATF6B gene Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944). Indicus|evm.model.CM009513.1.331 P01030 CO4_BOVIN 80.258 0.911215 0.232609 C4 - Complement C4 precursor - Bos taurus (Bovine) - C4 gene Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). Indicus|evm.model.CM009513.1.332 P00191 CP21A_BOVIN 89.100 0.534351 0.792339 CYP21 - Steroid 21-hydroxylase - Bos taurus (Bovine) - CYP21 gene A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:22262854). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791, PubMed:22262854). Indicus|evm.model.CM009513.1.333 P01030 CO4_BOVIN 96.970 0.0129379 5.46087 C4 - Complement C4 precursor - Bos taurus (Bovine) - C4 gene Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). Indicus|evm.model.CM009513.1.334 P01030 CO4_BOVIN 96.104 0.0413493 1.99783 C4 - Complement C4 precursor - Bos taurus (Bovine) - C4 gene Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). Indicus|evm.model.CM009513.1.335 P00191 CP21A_BOVIN 98.485 0.755814 0.173387 CYP21 - Steroid 21-hydroxylase - Bos taurus (Bovine) - CYP21 gene A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:22262854). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791, PubMed:22262854). Indicus|evm.model.CM009513.1.336 P00191 CP21A_BOVIN 96.364 0.8327 0.530242 CYP21 - Steroid 21-hydroxylase - Bos taurus (Bovine) - CYP21 gene A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:22262854). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791, PubMed:22262854). Indicus|evm.model.CM009513.1.337 P01030 CO4_BOVIN 98.701 0.0379431 2.17717 C4 - Complement C4 precursor - Bos taurus (Bovine) - C4 gene Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). Indicus|evm.model.CM009513.1.338 P49842 STK19_HUMAN 87.984 0.992157 0.692935 STK19 - Serine/threonine-protein kinase 19 - Homo sapiens (Human) - STK19 gene Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding to its downstream effectors. Indicus|evm.model.CM009513.1.339 Q5E9Y5 DXO_BOVIN 99.748 0.994975 1.00252 DXO - Decapping and exoribonuclease protein - Bos taurus (Bovine) - DXO gene Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Preferentially acts on NAD-capped transcripts in response to environmental stress (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA. Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Indicus|evm.model.CM009513.1.340 Q15477 SKIV2_HUMAN 94.783 0.998396 1.0008 SKIV2L - Helicase SKI2W - Homo sapiens (Human) - SKIV2L gene Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Indicus|evm.model.CM009513.1.341 Q0V898 NELFE_BOVIN 100.000 0.994667 1.00267 NELFE - Negative elongation factor E - Bos taurus (Bovine) - NELFE gene Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (By similarity). Indicus|evm.model.CM009513.1.342 P81187 CFAB_BOVIN 100.000 0.997375 1.00131 CFB - Complement factor B precursor - Bos taurus (Bovine) - CFB gene Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. Indicus|evm.model.CM009513.1.343 Q3SYW2 CO2_BOVIN 99.867 0.997337 1.00133 C2 - Complement C2 precursor - Bos taurus (Bovine) - C2 gene Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Indicus|evm.model.CM009513.1.344 Q9Y330 ZBT12_HUMAN 98.911 0.995652 1.00218 ZBTB12 - Zinc finger and BTB domain-containing protein 12 - Homo sapiens (Human) - ZBTB12 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.345 Q96KQ7 EHMT2_HUMAN 97.983 0.997483 0.985124 EHMT2 - Histone-lysine N-methyltransferase EHMT2 - Homo sapiens (Human) - EHMT2 gene Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. Indicus|evm.model.CM009513.1.346 A3KMY4 CTL4_BOVIN 92.504 0.99705 0.958982 SLC44A4 - Choline transporter-like protein 4 - Bos taurus (Bovine) - SLC44A4 gene Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (By similarity). Indicus|evm.model.CM009513.1.347 A6BMK7 NEUR1_BOVIN 99.759 0.995192 1.00241 NEU1 - Sialidase-1 precursor - Bos taurus (Bovine) - NEU1 gene Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage (By similarity). Indicus|evm.model.CM009513.1.348 Q27965 HS71B_BOVIN 100.000 0.996885 1.00156 HSPA1B - Heat shock 70 kDa protein 1B - Bos taurus (Bovine) - HSPA1B gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. Indicus|evm.model.CM009513.1.349 P0CB32 HS71L_BOVIN 99.844 0.996885 1.00156 HSPA1L - Heat shock 70 kDa protein 1-like - Bos taurus (Bovine) - HSPA1L gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria. Indicus|evm.model.CM009513.1.350 O35900 LSM2_MOUSE 100.000 0.979167 1.01053 Lsm2 - U6 snRNA-associated Sm-like protein LSm2 - Mus musculus (Mouse) - Lsm2 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Indicus|evm.model.CM009513.1.351 P26640 SYVC_HUMAN 94.570 0.894309 0.19462 VARS1 - Valine--tRNA ligase - Homo sapiens (Human) - VARS1 gene cytosol, valine-tRNA ligase activity, tRNA aminoacylation for protein translation, valyl-tRNA aminoacylation Indicus|evm.model.CM009513.1.352 Q0V8J4 VWA7_BOVIN 98.583 0.982578 0.96633 VWA7 - von Willebrand factor A domain-containing protein 7 precursor - Bos taurus (Bovine) - VWA7 gene Indicus|evm.model.CM009513.1.353 P26640 SYVC_HUMAN 95.253 0.997938 0.767405 VARS1 - Valine--tRNA ligase - Homo sapiens (Human) - VARS1 gene cytosol, valine-tRNA ligase activity, tRNA aminoacylation for protein translation, valyl-tRNA aminoacylation Indicus|evm.model.CM009513.1.354 O43196 MSH5_HUMAN 92.446 0.997596 0.997602 MSH5 - MutS protein homolog 5 - Homo sapiens (Human) - MSH5 gene Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity). Indicus|evm.model.CM009513.1.355 Q5E9B7 CLIC1_BOVIN 100.000 0.991736 1.00415 CLIC1 - Chloride intracellular channel protein 1 - Bos taurus (Bovine) - CLIC1 gene Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). Indicus|evm.model.CM009513.1.356 Q3SX44 DDAH2_BOVIN 100.000 0.993007 1.00351 DDAH2 - N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 - Bos taurus (Bovine) - DDAH2 gene Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity). Indicus|evm.model.CM009513.1.357 O95866 G6B_HUMAN 77.293 0.937238 0.991701 MPIG6B - Megakaryocyte and platelet inhibitory receptor G6b precursor - Homo sapiens (Human) - MPIG6B gene Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801). Indicus|evm.model.CM009513.1.358 A0JNL5 LY66C_BOVIN 100.000 0.984127 1.008 LY6G6C - Lymphocyte antigen 6 complex locus protein G6c precursor - Bos taurus (Bovine) - LY6G6C gene protein-containing complex Indicus|evm.model.CM009513.1.359 O95868 LY66D_HUMAN 65.248 0.984848 0.992481 LY6G6D - Lymphocyte antigen 6 complex locus protein G6d precursor - Homo sapiens (Human) - LY6G6D gene extracellular region, plasma membrane, protein-containing complex, acetylcholine receptor inhibitor activity, identical protein binding, acetylcholine receptor signaling pathway Indicus|evm.model.CM009513.1.360 Q8K1T6 LY66E_MOUSE 51.515 0.81761 0.957831 Ly6g6e - Lymphocyte antigen 6G6e precursor - Mus musculus (Mouse) - Ly6g6e gene Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro potentiates alpha-3:beta-4-containing nAChRs maximum response by increasing peak current and slowing down receptor desensitization; the activity is dependent on its cell surface localization. Indicus|evm.model.CM009513.1.361 Q0V881 LY66F_BOVIN 98.282 0.989761 0.979933 LY6G6F - Lymphocyte antigen 6 complex locus protein G6f precursor - Bos taurus (Bovine) - LY6G6F gene May play a role in the downstream signal transduction pathways involving GRB2 and GRB7. Indicus|evm.model.CM009513.1.362 Q1JPD2 ABHGA_BOVIN 100.000 0.996422 1.00179 ABHD16A - Phosphatidylserine lipase ABHD16A - Bos taurus (Bovine) - ABHD16A gene Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (By similarity). Indicus|evm.model.CM009513.1.363 Q8NDX9 LY65B_HUMAN 73.333 0.979798 0.985075 LY6G5B - Lymphocyte antigen 6 complex locus protein G5b precursor - Homo sapiens (Human) - LY6G5B gene protein-containing complex, identical protein binding Indicus|evm.model.CM009513.1.364 P67874 CSK2B_RAT 100.000 0.90678 1.09767 Csnk2b - Casein kinase II subunit beta - Rattus norvegicus (Rat) - Csnk2b gene Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:16818610). Participates in Wnt signaling (By similarity). Indicus|evm.model.CM009513.1.365 O95872 GPAN1_HUMAN 82.584 0.994318 0.988764 GPANK1 - G patch domain and ankyrin repeat-containing protein 1 - Homo sapiens (Human) - GPANK1 gene Indicus|evm.model.CM009513.1.366 O95873 CF047_HUMAN 79.866 0.993289 1.01361 C6orf47 - Uncharacterized protein C6orf47 - Homo sapiens (Human) - C6orf47 gene Indicus|evm.model.CM009513.1.367 Q2LE37 APOM_PIG 94.681 0.989418 1.00532 APOM - Apolipoprotein M - Sus scrofa (Pig) - APOM gene Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid (By similarity). Indicus|evm.model.CM009513.1.368 A5D9M6 BAG6_PIG 96.365 0.929101 1.07535 BAG6 - Large proline-rich protein BAG6 - Sus scrofa (Pig) - BAG6 gene ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response. BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress. By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis. Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Indicus|evm.model.CM009513.1.369 Q5TM26 PRC2A_MACMU 91.429 0.999072 0.997685 PRRC2A - Protein PRRC2A - Macaca mulatta (Rhesus macaque) - PRRC2A gene May play a role in the regulation of pre-mRNA splicing. Indicus|evm.model.CM009513.1.370 Q9BDK2 AIF1_BOVIN 100.000 0.791908 1.17687 AIF1 - Allograft inflammatory factor 1 - Bos taurus (Bovine) - AIF1 gene May play a role in macrophage activation and function. Indicus|evm.model.CM009513.1.371 P61483 NCTR3_MACFA 80.682 0.821596 1.21023 NCR3 - Natural cytotoxicity triggering receptor 3 precursor - Macaca fascicularis (Crab-eating macaque) - NCR3 gene Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation. Indicus|evm.model.CM009513.1.372 O00453 LST1_HUMAN 72.059 0.62 1.03093 LST1 - Leukocyte-specific transcript 1 protein - Homo sapiens (Human) - LST1 gene Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. Indicus|evm.model.CM009513.1.373 Q9TSV8 TNFC_PIG 92.667 0.603239 1.64667 LTB - Lymphotoxin-beta - Sus scrofa (Pig) - LTB gene Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Indicus|evm.model.CM009513.1.374 Q2MH05 TNFA_BUBCA 100.000 0.991489 1.00427 TNF - Tumor necrosis factor precursor - Bubalus carabanensis (Swamp type water buffalo) - TNF gene Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Indicus|evm.model.CM009513.1.375 Q06600 TNFB_BOVIN 100.000 0.852941 1.16667 LTA - Lymphotoxin-alpha precursor - Bos taurus (Bovine) - LTA gene Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. Indicus|evm.model.CM009513.1.376 Q9TSV7 IKBL1_PIG 97.375 0.994764 1.00526 NFKBIL1 - NF-kappa-B inhibitor-like protein 1 - Sus scrofa (Pig) - NFKBIL1 gene Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). Indicus|evm.model.CM009513.1.377 Q9TSV6 VATG2_PIG 91.549 0.522727 1.11864 ATP6V1G2 - V-type proton ATPase subunit G 2 - Sus scrofa (Pig) - ATP6V1G2 gene Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Indicus|evm.model.CM009513.1.378 Q3T147 DX39B_BOVIN 100.000 0.995338 1.00234 DDX39B - Spliceosome RNA helicase DDX39B - Bos taurus (Bovine) - DDX39B gene Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. Indicus|evm.model.CM009513.1.379 P59942 MCCD1_HUMAN 66.372 0.692308 1.31092 MCCD1 - Mitochondrial coiled-coil domain protein 1 precursor - Homo sapiens (Human) - MCCD1 gene Indicus|evm.model.CM009513.1.380 P30387 1C04_GORGO 59.498 0.822485 0.923497 Class I histocompatibility antigen, Gogo-C*0203 alpha chain precursor - Gorilla gorilla gorilla (Western lowland gorilla) Indicus|evm.model.CM009513.1.381 P23004 QCR2_BOVIN 98.234 0.995595 1.00221 UQCRC2 - Cytochrome b-c1 complex subunit 2, mitochondrial precursor - Bos taurus (Bovine) - UQCRC2 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (PubMed:9694818, PubMed:11073949). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Indicus|evm.model.CM009513.1.382 Q01628 IFM3_HUMAN 69.355 0.836735 1.10526 IFITM3 - Interferon-induced transmembrane protein 3 - Homo sapiens (Human) - IFITM3 gene IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33270927). Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). Exerts opposing activities on SARS-CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane (PubMed:33270927). Indicus|evm.model.CM009513.1.383 P13752 HA1A_BOVIN 82.216 0.936813 1.01111 BOLA class I histocompatibility antigen, alpha chain BL3-6 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009513.1.389 Q767M3 SYVM_PIG 91.981 0.924084 1.0791 VARS2 - Valine--tRNA ligase, mitochondrial precursor - Sus scrofa (Pig) - VARS2 gene cytosol, valine-tRNA ligase activity, valyl-tRNA aminoacylation Indicus|evm.model.CM009513.1.390 P60027 TF2H4_PANTR 98.704 0.99569 1.00433 GTF2H4 - General transcription factor IIH subunit 4 - Pan troglodytes (Chimpanzee) - GTF2H4 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Indicus|evm.model.CM009513.1.391 Q08345 DDR1_HUMAN 92.123 0.99776 0.978094 DDR1 - Epithelial discoidin domain-containing receptor 1 precursor - Homo sapiens (Human) - DDR1 gene Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Indicus|evm.model.CM009513.1.394 Q7YR42 IEX1_PANTR 82.051 0.987261 1.00641 IER3 - Radiation-inducible immediate-early gene IEX-1 - Pan troglodytes (Chimpanzee) - IER3 gene May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment (By similarity). Indicus|evm.model.CM009513.1.395 Q08DN8 FLOT1_BOVIN 100.000 0.995327 1.00234 FLOT1 - Flotillin-1 - Bos taurus (Bovine) - FLOT1 gene May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. Indicus|evm.model.CM009513.1.396 P09244 TBB7_CHICK 100.000 0.995506 1.00225 Tubulin beta-7 chain - Gallus gallus (Chicken) Indicus|evm.model.CM009513.1.397 Q32LM8 NRM_BOVIN 100.000 0.992395 1.00382 NRM - Nurim - Bos taurus (Bovine) - NRM gene nuclear envelope, nuclear membrane Indicus|evm.model.CM009513.1.398 Q14676 MDC1_HUMAN 65.517 0.469516 0.840115 MDC1 - Mediator of DNA damage checkpoint protein 1 - Homo sapiens (Human) - MDC1 gene Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. Indicus|evm.model.CM009513.1.399 Q767M0 PPR18_PIG 84.244 0.996716 0.985437 PPP1R18 - Phostensin - Sus scrofa (Pig) - PPP1R18 gene May target protein phosphatase 1 to F-actin cytoskeleton. Indicus|evm.model.CM009513.1.400 Q7YR39 DHX16_PANTR 97.799 0.998088 1.00192 DHX16 - Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 - Pan troglodytes (Chimpanzee) - DHX16 gene Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. Indicus|evm.model.CM009513.1.401 Q32KT5 CF136_BOVIN 99.683 0.418667 2.38095 Uncharacterized protein C6orf136 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009513.1.402 P82918 RT18B_BOVIN 99.225 0.992278 1.00388 MRPS18B - 28S ribosomal protein S18b, mitochondrial precursor - Bos taurus (Bovine) - MRPS18B gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009513.1.403 Q767K9 PP1RA_PIG 97.946 0.997838 1 PPP1R10 - Serine/threonine-protein phosphatase 1 regulatory subunit 10 - Sus scrofa (Pig) - PPP1R10 gene Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). Indicus|evm.model.CM009513.1.404 Q8NE71 ABCF1_HUMAN 96.938 0.997636 1.00118 ABCF1 - ATP-binding cassette sub-family F member 1 - Homo sapiens (Human) - ABCF1 gene Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. Indicus|evm.model.CM009513.1.405 Q767L1 PRR3_PIG 97.710 0.691489 1.43511 PRR3 - Proline-rich protein 3 - Sus scrofa (Pig) - PRR3 gene Indicus|evm.model.CM009513.1.406 Q5RA07 GNL1_PONAB 97.336 0.945631 0.848435 GNL1 - Guanine nucleotide-binding protein-like 1 - Pongo abelii (Sumatran orangutan) - GNL1 gene Possible regulatory or functional link with the histocompatibility cluster. Indicus|evm.model.CM009513.1.407 Q5RA07 GNL1_PONAB 96.341 0.399015 0.334432 GNL1 - Guanine nucleotide-binding protein-like 1 - Pongo abelii (Sumatran orangutan) - GNL1 gene Possible regulatory or functional link with the histocompatibility cluster. Indicus|evm.model.CM009513.1.408 Q9ESN2 TRI39_MOUSE 97.541 0.99591 1.00205 Trim39 - E3 ubiquitin-protein ligase TRIM39 - Mus musculus (Mouse) - Trim39 gene E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similarity). Indicus|evm.model.CM009513.1.409 Q5RA31 TOM20_PONAB 98.990 0.796748 0.848276 TOMM20 - Mitochondrial import receptor subunit TOM20 homolog - Pongo abelii (Sumatran orangutan) - TOMM20 gene Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. Indicus|evm.model.CM009513.1.410 P13753 HA1B_BOVIN 53.209 0.705996 1.42033 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009513.1.411 P13753 HA1B_BOVIN 78.711 0.926136 0.967033 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009513.1.412 P13753 HA1B_BOVIN 82.353 0.803612 1.21703 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009513.1.413 P13753 HA1B_BOVIN 90.385 0.91716 0.464286 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009513.1.414 D4A615 TONSL_RAT 66.667 0.308943 0.0899781 Tonsl - Tonsoku-like protein - Rattus norvegicus (Rat) - Tonsl gene Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). Indicus|evm.model.CM009513.1.415 P13753 HA1B_BOVIN 87.773 0.621253 1.00824 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009513.1.416 Q56JY1 RL35A_BOVIN 96.364 0.95614 1.03636 RPL35A - 60S ribosomal protein L35a - Bos taurus (Bovine) - RPL35A gene Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation (By similarity). The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (By similarity). Indicus|evm.model.CM009513.1.417 P13753 HA1B_BOVIN 90.582 0.802299 1.19505 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009513.1.418 Q12899 TRI26_HUMAN 57.552 0.837719 0.846011 TRIM26 - Tripartite motif-containing protein 26 - Homo sapiens (Human) - TRIM26 gene E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Indicus|evm.model.CM009513.1.419 Q12899 TRI26_HUMAN 94.249 0.996296 1.00186 TRIM26 - Tripartite motif-containing protein 26 - Homo sapiens (Human) - TRIM26 gene E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Indicus|evm.model.CM009513.1.420 Q9TSW0 TRI15_PIG 90.672 0.995671 1.00217 TRIM15 - Tripartite motif-containing protein 15 - Sus scrofa (Pig) - TRIM15 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, positive regulation of NF-kappaB transcription factor activity, protein ubiquitination, regulation of gene expression Indicus|evm.model.CM009513.1.421 Q5E9G4 TRI10_BOVIN 100.000 0.995918 1.00204 TRIM10 - Tripartite motif-containing protein 10 - Bos taurus (Bovine) - TRIM10 gene Seems to play an important role in erythropoiesis. Indicus|evm.model.CM009513.1.422 Q6P9F5 TRI40_HUMAN 67.717 0.812298 1.19767 TRIM40 - E3 ubiquitin ligase TRIM40 - Homo sapiens (Human) - TRIM40 gene E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response (PubMed:21474709, PubMed:29117565). Mediates inhibition of the RLR signaling pathway by ubiquitinating DDX58 and IFIH1 receptors, leading to their proteasomal degradation (PubMed:21474709). Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation (PubMed:21474709). Indicus|evm.model.CM009513.1.423 Q9BZY9 TRI31_HUMAN 62.717 0.6 1.35294 TRIM31 - E3 ubiquitin-protein ligase TRIM31 - Homo sapiens (Human) - TRIM31 gene Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity. Indicus|evm.model.CM009513.1.424 Q7YR31 RNF39_PANTR 90.045 0.88 0.595238 RNF39 - RING finger protein 39 - Pan troglodytes (Chimpanzee) - RNF39 gene May play a role in prolonged long term-potentiation (LTP) maintenance. Indicus|evm.model.CM009513.1.425 Q7YR30 PP1RB_PANTR 96.032 0.984252 1.00794 PPP1R11 - E3 ubiquitin-protein ligase PPP1R11 - Pan troglodytes (Chimpanzee) - PPP1R11 gene Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1. Indicus|evm.model.CM009513.1.426 Q1RMP0 RPA12_BOVIN 100.000 0.983871 1.00813 POLR1H - DNA-directed RNA polymerase I subunit RPA12 - Bos taurus (Bovine) - POLR1H gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Indicus|evm.model.CM009513.1.427 Q8R0E5 ZRAS1_MOUSE 59.116 0.497238 1.69953 Znrd1-as - Putative uncharacterized protein ZNRD1-AS1 - Mus musculus (Mouse) - Znrd1-as gene May be involved in male sterility. Indicus|evm.model.CM009513.1.428 Q9NU63 ZFP57_HUMAN 48.473 0.924354 1.19912 ZFP57 - Zinc finger protein 57 homolog - Homo sapiens (Human) - ZFP57 gene Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:18622393, PubMed:30602440). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Indicus|evm.model.CM009513.1.429 P55803 MOG_BOVIN 100.000 0.991903 1.00407 MOG - Myelin-oligodendrocyte glycoprotein precursor - Bos taurus (Bovine) - MOG gene Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Indicus|evm.model.CM009513.1.430 Q9UBS5 GABR1_HUMAN 99.596 0.748485 1.03018 GABBR1 - Gamma-aminobutyric acid type B receptor subunit 1 precursor - Homo sapiens (Human) - GABBR1 gene Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9844003, PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:9844003, PubMed:9872316, PubMed:24305054). Indicus|evm.model.CM009513.1.431 Q8NGU4 OR2I1_HUMAN 63.441 0.75 0.35443 OR2I1P - Putative olfactory receptor 2I1 - Homo sapiens (Human) - OR2I1P gene Odorant receptor. Indicus|evm.model.CM009513.1.432 O15205 UBD_HUMAN 71.605 0.332645 2.93333 UBD - Ubiquitin D - Homo sapiens (Human) - UBD gene Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). Indicus|evm.model.CM009513.1.433 Q8NGU4 OR2I1_HUMAN 67.227 0.405498 0.920886 OR2I1P - Putative olfactory receptor 2I1 - Homo sapiens (Human) - OR2I1P gene Odorant receptor. Indicus|evm.model.CM009513.1.434 Q921A3 UBD_RAT 70.000 0.97546 1.01242 Ubd - Ubiquitin D - Rattus norvegicus (Rat) - Ubd gene Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases (By similarity). Indicus|evm.model.CM009513.1.435 O95918 OR2H2_HUMAN 82.051 0.987179 0.25 OR2H2 - Olfactory receptor 2H2 - Homo sapiens (Human) - OR2H2 gene Odorant receptor. Indicus|evm.model.CM009513.1.436 Q9GZK4 OR2H1_HUMAN 85.965 0.896825 0.398734 OR2H1 - Olfactory receptor 2H1 - Homo sapiens (Human) - OR2H1 gene Odorant receptor. Indicus|evm.model.CM009513.1.437 O15205 UBD_HUMAN 71.429 0.981595 0.987879 UBD - Ubiquitin D - Homo sapiens (Human) - UBD gene Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). Indicus|evm.model.CM009513.1.438 Q9GZK7 O11A1_HUMAN 76.433 0.939759 0.526984 OR11A1 - Olfactory receptor 11A1 - Homo sapiens (Human) - OR11A1 gene Odorant receptor. Indicus|evm.model.CM009513.1.439 P58182 O12D2_HUMAN 83.007 0.987055 1.00651 OR12D2 - Olfactory receptor 12D2 - Homo sapiens (Human) - OR12D2 gene Odorant receptor. Indicus|evm.model.CM009513.1.440 P58182 O12D2_HUMAN 82.026 0.987055 1.00651 OR12D2 - Olfactory receptor 12D2 - Homo sapiens (Human) - OR12D2 gene Odorant receptor. Indicus|evm.model.CM009513.1.441 Q9UGF7 O12D3_HUMAN 80.696 0.993691 1.00316 OR12D3 - Olfactory receptor 12D3 - Homo sapiens (Human) - OR12D3 gene Odorant receptor. Indicus|evm.model.CM009513.1.442 Q9UGF5 O14J1_HUMAN 73.653 0.706383 0.732087 OR14J1 - Olfactory receptor 14J1 - Homo sapiens (Human) - OR14J1 gene Odorant receptor. Indicus|evm.model.CM009513.1.443 Q9UGF5 O14J1_HUMAN 87.539 0.993789 1.00312 OR14J1 - Olfactory receptor 14J1 - Homo sapiens (Human) - OR14J1 gene Odorant receptor. Indicus|evm.model.CM009513.1.444 O95918 OR2H2_HUMAN 64.626 0.930159 1.00962 OR2H2 - Olfactory receptor 2H2 - Homo sapiens (Human) - OR2H2 gene Odorant receptor. Indicus|evm.model.CM009513.1.445 Q8NHA6 OR2W6_HUMAN 59.341 0.75 0.377358 OR2W6P - Putative olfactory receptor 2W6 - Homo sapiens (Human) - OR2W6P gene Odorant receptor. Indicus|evm.model.CM009513.1.447 A6QLZ5 F177A_BOVIN 94.393 0.990698 1.01415 FAM177A1 - Protein FAM177A1 - Bos taurus (Bovine) - FAM177A1 gene Indicus|evm.model.CM009513.1.448 Q5RFL9 NONO_PONAB 98.291 0.983051 0.250531 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009513.1.449 Q5RFL9 NONO_PONAB 97.073 0.990148 0.430998 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009513.1.450 Q5RFL9 NONO_PONAB 78.689 0.915966 0.252654 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009513.1.451 Q9Y3N9 OR2W1_HUMAN 86.782 0.988571 0.546875 OR2W1 - Olfactory receptor 2W1 - Homo sapiens (Human) - OR2W1 gene Odorant receptor. Indicus|evm.model.CM009513.1.452 Q9Y3N9 OR2W1_HUMAN 86.667 0.809524 0.459375 OR2W1 - Olfactory receptor 2W1 - Homo sapiens (Human) - OR2W1 gene Odorant receptor. Indicus|evm.model.CM009513.1.455 Q5JNZ3 ZN311_HUMAN 76.579 0.99537 0.972973 ZNF311 - Zinc finger protein 311 - Homo sapiens (Human) - ZNF311 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.456 P14373 TRI27_HUMAN 99.415 0.996109 1.00195 TRIM27 - Zinc finger protein RFP - Homo sapiens (Human) - TRIM27 gene E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. Indicus|evm.model.CM009513.1.457 P68105 EF1A1_RABIT 98.380 0.930886 1.00216 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009513.1.458 A1YEP8 ZSC12_GORGO 84.743 0.808108 1.22517 ZSCAN12 - Zinc finger and SCAN domain-containing protein 12 - Gorilla gorilla gorilla (Western lowland gorilla) - ZSCAN12 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.459 Q96LW9 ZSC31_HUMAN 78.325 0.928899 1.07389 ZSCAN31 - Zinc finger and SCAN domain-containing protein 31 - Homo sapiens (Human) - ZSCAN31 gene May function as a transcription factor. May be involved in the development of multiple embryonic organs. Indicus|evm.model.CM009513.1.460 Q96JS3 PGBD1_HUMAN 76.010 0.997522 0.997528 PGBD1 - PiggyBac transposable element-derived protein 1 - Homo sapiens (Human) - PGBD1 gene DNA-binding transcription factor activity, RNA polymerase II-specific, identical protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009513.1.461 A6QNZ0 ZSC26_BOVIN 99.791 0.995833 1.00209 ZSCAN26 - Zinc finger and SCAN domain-containing protein 26 - Bos taurus (Bovine) - ZSCAN26 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.462 Q8N5F7 NKAP_HUMAN 86.713 0.355 0.963855 NKAP - NF-kappa-B-activating protein - Homo sapiens (Human) - NKAP gene Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. Indicus|evm.model.CM009513.1.463 Q969J2 ZKSC4_HUMAN 81.835 0.994485 0.998165 ZKSCAN4 - Zinc finger protein with KRAB and SCAN domains 4 - Homo sapiens (Human) - ZKSCAN4 gene May be involved in the transcriptional activation of MDM2 and EP300 genes. Indicus|evm.model.CM009513.1.464 O15535 ZSC9_HUMAN 75.381 0.994565 0.93401 ZSCAN9 - Zinc finger and SCAN domain-containing protein 9 - Homo sapiens (Human) - ZSCAN9 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.465 Q15007 FL2D_HUMAN 95.926 0.817629 0.830808 WTAP - Pre-mRNA-splicing regulator WTAP - Homo sapiens (Human) - WTAP gene Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724). Indicus|evm.model.CM009513.1.466 A1YEP8 ZSC12_GORGO 52.258 0.191906 1.26821 ZSCAN12 - Zinc finger and SCAN domain-containing protein 12 - Gorilla gorilla gorilla (Western lowland gorilla) - ZSCAN12 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.467 Q1LZ87 ZN397_BOVIN 68.718 0.713235 0.509363 ZNF397 - Zinc finger protein 397 - Bos taurus (Bovine) - ZNF397 gene DNA-dependent transcriptional repressor. Indicus|evm.model.CM009513.1.468 A2T736 ZKSC8_PANTR 92.907 0.996546 1.00173 ZKSCAN8 - Zinc finger protein with KRAB and SCAN domains 8 - Pan troglodytes (Chimpanzee) - ZKSCAN8 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.469 Q9H4T2 ZSC16_HUMAN 80.180 0.794964 0.798851 ZSCAN16 - Zinc finger and SCAN domain-containing protein 16 - Homo sapiens (Human) - ZSCAN16 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.471 P49910 ZN165_HUMAN 80.412 0.995885 1.00206 ZNF165 - Zinc finger protein 165 - Homo sapiens (Human) - ZNF165 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.473 P13753 HA1B_BOVIN 63.354 0.740741 0.593407 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009513.1.474 P13752 HA1A_BOVIN 82.609 0.446078 0.566667 BOLA class I histocompatibility antigen, alpha chain BL3-6 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009513.1.475 Q8NHA6 OR2W6_HUMAN 72.483 0.973684 0.477987 OR2W6P - Putative olfactory receptor 2W6 - Homo sapiens (Human) - OR2W6P gene Odorant receptor. Indicus|evm.model.CM009513.1.476 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009513.1.477 P0C0S8 H2A1_HUMAN 100.000 0.984733 1.00769 H2AC11 - Histone H2A type 1 - Homo sapiens (Human) - H2AC11 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.478 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Indicus|evm.model.CM009513.1.479 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009513.1.480 Q99877 H2B1N_HUMAN 100.000 0.984252 1.00794 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.481 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009513.1.482 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009513.1.483 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Indicus|evm.model.CM009513.1.484 Q99878 H2A1J_HUMAN 100.000 0.984496 1.00781 H2AC14 - Histone H2A type 1-J - Homo sapiens (Human) - H2AC14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.485 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009513.1.486 A2Q0Z0 EF1A1_HORSE 99.419 0.534375 0.692641 EEF1A1 - Elongation factor 1-alpha 1 - Equus caballus (Horse) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009513.1.489 A6QLU5 ZN184_BOVIN 100.000 0.997344 1.00133 ZNF184 - Zinc finger protein 184 - Bos taurus (Bovine) - ZNF184 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009513.1.490 Q96KW2 P12L2_HUMAN 63.916 0.99806 0.996135 POM121L2 - POM121-like protein 2 - Homo sapiens (Human) - POM121L2 gene nuclear pore, nuclear localization sequence binding, structural constituent of nuclear pore, protein import into nucleus, RNA export from nucleus Indicus|evm.model.CM009513.1.491 Q9NQE7 TSSP_HUMAN 81.818 0.855186 0.994163 PRSS16 - Thymus-specific serine protease precursor - Homo sapiens (Human) - PRSS16 gene Protease that may play a role in T-cell development. Indicus|evm.model.CM009513.1.492 Q96KK5 H2A1H_HUMAN 100.000 0.984496 1.00781 H2AC12 - Histone H2A type 1-H - Homo sapiens (Human) - H2AC12 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.493 O60814 H2B1K_HUMAN 100.000 0.984252 1.00794 H2BC12 - Histone H2B type 1-K - Homo sapiens (Human) - H2BC12 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.494 P0C0S8 H2A1_HUMAN 100.000 0.565789 1.75385 H2AC11 - Histone H2A type 1 - Homo sapiens (Human) - H2AC11 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.495 P06899 H2B1J_HUMAN 99.206 0.984252 1.00794 H2BC11 - Histone H2B type 1-J - Homo sapiens (Human) - H2BC11 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.497 Q4R7X8 ZN322_MACFA 94.776 0.995037 1.00249 ZNF322 - Zinc finger protein 322 - Macaca fascicularis (Crab-eating macaque) - ZNF322 gene Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation. Indicus|evm.model.CM009513.1.498 Q148M8 ABT1_BOVIN 99.636 0.992754 1.00364 ABT1 - Activator of basal transcription 1 - Bos taurus (Bovine) - ABT1 gene Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). Indicus|evm.model.CM009513.1.500 Q2YDK4 HMGN4_BOVIN 98.889 0.978022 1.01111 HMGN4 - High mobility group nucleosome-binding domain-containing protein 4 - Bos taurus (Bovine) - HMGN4 gene nucleus, chromatin binding, chromatin organization Indicus|evm.model.CM009513.1.502 P18892 BT1A1_BOVIN 98.195 0.514925 1.01901 BTN1A1 - Butyrophilin subfamily 1 member A1 precursor - Bos taurus (Bovine) - BTN1A1 gene May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Indicus|evm.model.CM009513.1.503 Q7KYR7 BT2A1_HUMAN 70.432 0.659341 0.863378 BTN2A1 - Butyrophilin subfamily 2 member A1 precursor - Homo sapiens (Human) - BTN2A1 gene external side of plasma membrane, integral component of plasma membrane, plasma membrane, signaling receptor binding, adaptive immune response, lipid metabolic process, regulation of cytokine production, T cell receptor signaling pathway Indicus|evm.model.CM009513.1.504 Q13410 BT1A1_HUMAN 54.622 0.695522 0.636882 BTN1A1 - Butyrophilin subfamily 1 member A1 precursor - Homo sapiens (Human) - BTN1A1 gene May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Indicus|evm.model.CM009513.1.505 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009513.1.506 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009513.1.507 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Indicus|evm.model.CM009513.1.508 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009513.1.509 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Indicus|evm.model.CM009513.1.510 Q6WV90 H4_MYTGA 97.959 0.484848 0.961165 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009513.1.511 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009513.1.512 A7MAZ5 H13_BOVIN 99.548 0.990991 1.00452 H1-3 - Histone H1.3 - Bos taurus (Bovine) - H1-3 gene H1 histones bind to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. H1 histones are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Indicus|evm.model.CM009513.1.513 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Indicus|evm.model.CM009513.1.514 Q6WV90 H4_MYTGA 100.000 0.380597 2.60194 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009513.1.515 C0HKE9 H2A1P_MOUSE 100.000 0.984733 1.00769 Hist1h2ap - Histone H2A type 1-P - Mus musculus (Mouse) - Hist1h2ap gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.516 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009513.1.517 P0C0S8 H2A1_HUMAN 100.000 0.984733 1.00769 H2AC11 - Histone H2A type 1 - Homo sapiens (Human) - H2AC11 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.518 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Indicus|evm.model.CM009513.1.519 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009513.1.520 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009513.1.521 P10854 H2B1M_MOUSE 100.000 0.984252 1.00794 H2bc14 - Histone H2B type 1-M - Mus musculus (Mouse) - H2bc14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.522 P10412 H14_HUMAN 98.630 0.990909 1.00457 H1-4 - Histone H1.4 - Homo sapiens (Human) - H1-4 gene Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Indicus|evm.model.CM009513.1.523 P0C169 H2A1C_RAT 100.000 0.984733 1.00769 Histone H2A type 1-C - Rattus norvegicus (Rat) Indicus|evm.model.CM009513.1.524 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009513.1.525 P06348 H1T_PIG 79.006 0.918367 0.92891 H1-6 - Histone H1t - Sus scrofa (Pig) - H1-6 gene Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration. Indicus|evm.model.CM009513.1.526 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009513.1.527 Q9GL42 HFE_DICSU 81.180 0.994398 1.02586 HFE - Hereditary hemochromatosis protein homolog precursor - Dicerorhinus sumatrensis (Sumatran rhinoceros) - HFE gene Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. Indicus|evm.model.CM009513.1.528 P02253 H12_BOVIN 100.000 0.990654 1.00469 H1-2 - Histone H1.2 - Bos taurus (Bovine) - H1-2 gene Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Indicus|evm.model.CM009513.1.529 Q6LED0 H31_RAT 100.000 0.762712 1.30147 Histone H3.1 - Rattus norvegicus (Rat) Indicus|evm.model.CM009513.1.530 P0CC09 H2A2A_RAT 97.101 0.918919 0.569231 H2ac18 - Histone H2A type 2-A - Rattus norvegicus (Rat) - H2ac18 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Indicus|evm.model.CM009513.1.531 P33778 H2B1B_HUMAN 99.206 0.984252 1.00794 H2BC3 - Histone H2B type 1-B - Homo sapiens (Human) - H2BC3 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.532 C0HKE9 H2A1P_MOUSE 100.000 0.984733 1.00769 Hist1h2ap - Histone H2A type 1-P - Mus musculus (Mouse) - Hist1h2ap gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.533 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Indicus|evm.model.CM009513.1.534 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009513.1.535 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009513.1.536 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Indicus|evm.model.CM009513.1.537 G3N131 H11_BOVIN 100.000 0.990868 1.00459 H1-1 - Histone H1.1 - Bos taurus (Bovine) - H1-1 gene H1 histones bind to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. H1 histones are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling (By similarity). Indicus|evm.model.CM009513.1.539 Q58DK8 TRI38_BOVIN 100.000 0.995662 1.00217 TRIM38 - E3 ubiquitin-protein ligase TRIM38 - Bos taurus (Bovine) - TRIM38 gene E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Indicus|evm.model.CM009513.1.540 Q32LF0 NPT3_BOVIN 99.791 0.995833 1.00209 SLC17A2 - Sodium-dependent phosphate transport protein 3 - Bos taurus (Bovine) - SLC17A2 gene Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (By similarity). Indicus|evm.model.CM009513.1.541 O00476 NPT4_HUMAN 72.063 0.635628 1.17619 SLC17A3 - Sodium-dependent phosphate transport protein 4 - Homo sapiens (Human) - SLC17A3 gene voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport. Indicus|evm.model.CM009513.1.542 Q28722 NPT1_RABIT 62.446 0.991471 1.0086 SLC17A1 - Sodium-dependent phosphate transport protein 1 - Oryctolagus cuniculus (Rabbit) - SLC17A1 gene Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney. Indicus|evm.model.CM009513.1.543 Q9Y2C5 S17A4_HUMAN 70.737 0.970852 0.897384 SLC17A4 - Probable small intestine urate exporter - Homo sapiens (Human) - SLC17A4 gene Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro). Indicus|evm.model.CM009513.1.544 Q99878 H2A1J_HUMAN 80.800 0.933884 0.945312 H2AC14 - Histone H2A type 1-J - Homo sapiens (Human) - H2AC14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.545 Q00729 H2B1A_RAT 95.276 0.984375 1.00787 H2bc1 - Histone H2B type 1-A - Rattus norvegicus (Rat) - H2bc1 gene Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.546 Q00729 H2B1A_RAT 94.488 0.684783 1.44882 H2bc1 - Histone H2B type 1-A - Rattus norvegicus (Rat) - H2bc1 gene Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.547 Q96QV6 H2A1A_HUMAN 80.153 0.703297 1.38931 H2AC1 - Histone H2A type 1-A - Homo sapiens (Human) - H2AC1 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009513.1.548 A5PJN0 SEGN_BOVIN 99.638 0.99278 1.00362 SCGN - Secretagogin - Bos taurus (Bovine) - SCGN gene cytosol, dendrite, neuron projection, nucleus, synapse, terminal bouton, calcium ion binding, regulation of cytosolic calcium ion concentration, regulation of long-term synaptic potentiation, regulation of presynaptic cytosolic calcium ion concentration Indicus|evm.model.CM009513.1.549 Q5VZK9 CARL1_HUMAN 91.061 0.998543 1.00146 CARMIL1 - F-actin-uncapping protein LRRC16A - Homo sapiens (Human) - CARMIL1 gene Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). Indicus|evm.model.CM009513.1.550 A2VDZ9 VAPB_BOVIN 95.169 0.795367 1.06584 VAPB - Vesicle-associated membrane protein-associated protein B - Bos taurus (Bovine) - VAPB gene Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. Indicus|evm.model.CM009513.1.551 O19074 CMAH_PIG 95.172 0.750865 1.32874 Cytidine monophosphate-N-acetylneuraminic acid hydroxylase - Sus scrofa (Pig) Indicus|evm.model.CM009513.1.552 Q3B7M3 RIPR2_BOVIN 99.606 0.970363 1.02953 RIPOR2 - Rho family-interacting cell polarization regulator 2 - Bos taurus (Bovine) - RIPOR2 gene Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing. Indicus|evm.model.CM009513.1.553 H3BNL8 ARMD2_HUMAN 68.261 0.991304 1 ARMH2 - Armadillo-like helical domain-containing protein 2 - Homo sapiens (Human) - ARMH2 gene Indicus|evm.model.CM009513.1.554 O75496 GEMI_HUMAN 75.676 0.983957 0.894737 GMNN - Geminin - Homo sapiens (Human) - GMNN gene Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:9635433, PubMed:14993212, PubMed:20129055, PubMed:24064211). It is degraded during the mitotic phase of the cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). Indicus|evm.model.CM009513.1.555 Q99LU8 CF062_MOUSE 99.127 0.991304 1.00437 Uncharacterized protein C6orf62 homolog - Mus musculus (Mouse) Indicus|evm.model.CM009513.1.556 Q9CQR4 ACO13_MOUSE 79.839 0.518987 1.69286 Acot13 - Acyl-coenzyme A thioesterase 13 - Mus musculus (Mouse) - Acot13 gene Catalyzes the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:19405909). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (PubMed:19405909). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity). May play a role in controlling adaptive thermogenesis (PubMed:24072708). Indicus|evm.model.CM009513.1.557 A7YWI9 TYDP2_BOVIN 99.725 0.994521 1.00275 TDP2 - Tyrosyl-DNA phosphodiesterase 2 - Bos taurus (Bovine) - TDP2 gene DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress. Indicus|evm.model.CM009513.1.558 Q5VV43 K0319_HUMAN 83.877 0.998126 0.995336 KIAA0319 - Dyslexia-associated protein KIAA0319 precursor - Homo sapiens (Human) - KIAA0319 gene Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. Indicus|evm.model.CM009513.1.559 Q3MSM3 SSDH_HYLLA 84.860 0.996205 0.985047 ALDH5A1 - Succinate-semialdehyde dehydrogenase, mitochondrial precursor - Hylobates lar (Common gibbon) - ALDH5A1 gene Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Indicus|evm.model.CM009513.1.560 P80109 PHLD_BOVIN 99.404 0.997619 1.00119 GPLD1 - Phosphatidylinositol-glycan-specific phospholipase D precursor - Bos taurus (Bovine) - GPLD1 gene This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. Indicus|evm.model.CM009513.1.561 Q4R4M1 MRS2_MACFA 89.951 0.916667 1.08824 MRS2 - Magnesium transporter MRS2 homolog, mitochondrial precursor - Macaca fascicularis (Crab-eating macaque) - MRS2 gene Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. Indicus|evm.model.CM009513.1.562 Q9UHG0 DCDC2_HUMAN 85.227 0.99095 0.928571 DCDC2 - Doublecortin domain-containing protein 2 - Homo sapiens (Human) - DCDC2 gene Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). Indicus|evm.model.CM009513.1.563 Q8IZ57 NRSN1_HUMAN 92.308 0.989796 1.00513 NRSN1 - Neurensin-1 - Homo sapiens (Human) - NRSN1 gene May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory consolidation (By similarity). Indicus|evm.model.CM009513.1.564 Q5R931 RL10_PONAB 65.909 0.713115 0.570093 RPL10 - 60S ribosomal protein L10 - Pongo abelii (Sumatran orangutan) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009513.1.565 O08989 RASM_MOUSE 81.373 0.943925 0.514423 Mras - Ras-related protein M-Ras precursor - Mus musculus (Mouse) - Mras gene Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway (By similarity). Indicus|evm.model.CM009513.1.566 O46415 FRIL_BOVIN 100.000 0.988636 1.00571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009513.1.568 P18917 PLRP4_BOVIN 96.818 0.948052 0.966527 PRP4 - Placental prolactin-related protein 4 precursor - Bos taurus (Bovine) - PRP4 gene Placental prolactin-related proteins may play a specific role during gestation. Indicus|evm.model.CM009513.1.569 P12402 PLRP3_BOVIN 68.545 0.84 1.17371 PRP3 - Placental prolactin-related protein 3 precursor - Bos taurus (Bovine) - PRP3 gene Placental prolactin-related proteins may play a specific role during gestation. Indicus|evm.model.CM009513.1.570 P12402 PLRP3_BOVIN 68.217 0.977099 0.615023 PRP3 - Placental prolactin-related protein 3 precursor - Bos taurus (Bovine) - PRP3 gene Placental prolactin-related proteins may play a specific role during gestation. Indicus|evm.model.CM009513.1.571 P05402 PLRP1_BOVIN 100.000 0.904959 1.01681 PRP1 - Placental prolactin-related protein 1 precursor - Bos taurus (Bovine) - PRP1 gene Placental prolactin-related proteins may play a specific role during gestation. Indicus|evm.model.CM009513.1.572 P05402 PLRP1_BOVIN 83.636 0.904959 1.01681 PRP1 - Placental prolactin-related protein 1 precursor - Bos taurus (Bovine) - PRP1 gene Placental prolactin-related proteins may play a specific role during gestation. Indicus|evm.model.CM009513.1.573 P19159 CSH2_BOVIN 99.087 0.848249 1.07983 CSH2 - Chorionic somatomammotropin hormone 2 precursor - Bos taurus (Bovine) - CSH2 gene extracellular space, hormone activity, prolactin receptor binding, female pregnancy, mammary gland development, positive regulation of cell population proliferation, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels Indicus|evm.model.CM009513.1.574 P19159 CSH2_BOVIN 96.296 0.249221 1.34874 CSH2 - Chorionic somatomammotropin hormone 2 precursor - Bos taurus (Bovine) - CSH2 gene extracellular space, hormone activity, prolactin receptor binding, female pregnancy, mammary gland development, positive regulation of cell population proliferation, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels Indicus|evm.model.CM009513.1.575 P19159 CSH2_BOVIN 76.842 0.979167 0.403361 CSH2 - Chorionic somatomammotropin hormone 2 precursor - Bos taurus (Bovine) - CSH2 gene extracellular space, hormone activity, prolactin receptor binding, female pregnancy, mammary gland development, positive regulation of cell population proliferation, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels Indicus|evm.model.CM009513.1.576 P12402 PLRP3_BOVIN 69.780 0.84186 1.00939 PRP3 - Placental prolactin-related protein 3 precursor - Bos taurus (Bovine) - PRP3 gene Placental prolactin-related proteins may play a specific role during gestation. Indicus|evm.model.CM009513.1.577 P12402 PLRP3_BOVIN 99.531 0.84127 1.1831 PRP3 - Placental prolactin-related protein 3 precursor - Bos taurus (Bovine) - PRP3 gene Placental prolactin-related proteins may play a specific role during gestation. Indicus|evm.model.CM009513.1.578 P09611 CSH1_BOVIN 100.000 0.987654 0.686441 CSH1 - Chorionic somatomammotropin hormone 1 precursor - Bos taurus (Bovine) - CSH1 gene extracellular space, hormone activity, prolactin receptor binding, female pregnancy, mammary gland development, positive regulation of cell population proliferation, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels Indicus|evm.model.CM009513.1.579 P01239 PRL_BOVIN 100.000 0.991304 1.00437 PRL - Prolactin precursor - Bos taurus (Bovine) - PRL gene Prolactin acts primarily on the mammary gland by promoting lactation. Indicus|evm.model.CM009513.1.581 P51859 HDGF_MOUSE 64.423 0.838983 0.995781 Hdgf - Hepatoma-derived growth factor - Mus musculus (Mouse) - Hdgf gene Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity). Indicus|evm.model.CM009513.1.583 Q06831 SOX4_MOUSE 100.000 0.253906 0.581818 Sox4 - Transcription factor SOX-4 - Mus musculus (Mouse) - Sox4 gene Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:8404853). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (PubMed:23562159). Indicus|evm.model.CM009513.1.585 Q5VV42 CDKAL_HUMAN 91.626 0.995086 0.702936 CDKAL1 - Threonylcarbamoyladenosine tRNA methylthiotransferase - Homo sapiens (Human) - CDKAL1 gene Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Indicus|evm.model.CM009513.1.587 O00716 E2F3_HUMAN 95.918 0.914439 0.804301 E2F3 - Transcription factor E2F3 - Homo sapiens (Human) - E2F3 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). Indicus|evm.model.CM009513.1.588 O00716 E2F3_HUMAN 92.929 0.592593 0.348387 E2F3 - Transcription factor E2F3 - Homo sapiens (Human) - E2F3 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). Indicus|evm.model.CM009513.1.589 Q6ZNC8 MBOA1_HUMAN 90.554 0.989817 0.991919 MBOAT1 - Lysophospholipid acyltransferase 1 - Homo sapiens (Human) - MBOAT1 gene Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor (PubMed:18772128). May play a role in neurite outgrowth during neuronal differentiation (By similarity). Indicus|evm.model.CM009513.1.593 A5PK27 R144B_BOVIN 99.013 0.993443 1.00329 RNF144B - E3 ubiquitin-protein ligase RNF144B - Bos taurus (Bovine) - RNF144B gene E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se (By similarity). Indicus|evm.model.CM009513.1.595 P35659 DEK_HUMAN 94.133 0.994681 1.00267 DEK - Protein DEK - Homo sapiens (Human) - DEK gene Involved in chromatin organization. Indicus|evm.model.CM009513.1.596 Q8NB78 KDM1B_HUMAN 95.377 0.997564 0.998783 KDM1B - Lysine-specific histone demethylase 1B - Homo sapiens (Human) - KDM1B gene Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Indicus|evm.model.CM009513.1.597 Q17QQ2 TPMT_BOVIN 100.000 0.99187 1.00408 TPMT - Thiopurine S-methyltransferase - Bos taurus (Bovine) - TPMT gene thiopurine S-methyltransferase activity Indicus|evm.model.CM009513.1.598 Q6VVB1 NHLC1_HUMAN 87.374 0.994937 1 NHLRC1 - E3 ubiquitin-protein ligase NHLRC1 - Homo sapiens (Human) - NHLRC1 gene E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. Indicus|evm.model.CM009513.1.599 Q9H1H9 KI13A_HUMAN 95.139 0.995389 0.961219 KIF13A - Kinesin-like protein KIF13A - Homo sapiens (Human) - KIF13A gene Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. Indicus|evm.model.CM009513.1.600 P49790 NU153_HUMAN 84.790 0.931278 1.05559 NUP153 - Nuclear pore complex protein Nup153 - Homo sapiens (Human) - NUP153 gene Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). Indicus|evm.model.CM009513.1.601 Q9UBU6 FA8A1_HUMAN 82.857 0.995227 1.01453 FAM8A1 - Protein FAM8A1 - Homo sapiens (Human) - FAM8A1 gene Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). Indicus|evm.model.CM009513.1.602 Q5R5X8 CAP2_PONAB 91.597 0.975359 1.02096 CAP2 - Adenylyl cyclase-associated protein 2 - Pongo abelii (Sumatran orangutan) - CAP2 gene May have a regulatory bifunctional role. Indicus|evm.model.CM009513.1.603 Q9BX46 RBM24_HUMAN 99.438 0.988827 0.758475 RBM24 - RNA-binding protein 24 - Homo sapiens (Human) - RBM24 gene Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29358667, PubMed:29104163). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed:29104163). Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (PubMed:20977548, PubMed:24356969). Involved in myogenic differentiation by regulating MYOG levels (PubMed:20977548). Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization (PubMed:24375645). Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (PubMed:29104163). Plays a role in the regulation of mRNA translation (PubMed:29358667). Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (PubMed:29358667). Binds to a huge amount of mRNAs (PubMed:29104163). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity). Indicus|evm.model.CM009513.1.604 H3BQB6 STMD1_HUMAN 68.841 0.992647 0.985507 STMND1 - Stathmin domain-containing protein 1 - Homo sapiens (Human) - STMND1 gene cytoplasm, neuron projection, tubulin binding, microtubule depolymerization, neuron projection development, regulation of microtubule polymerization or depolymerization Indicus|evm.model.CM009513.1.607 Q63540 ATX1_RAT 81.863 0.961039 1.07351 Atxn1 - Ataxin-1 - Rattus norvegicus (Rat) - Atxn1 gene Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved brain development. Indicus|evm.model.CM009513.1.608 Q9Z244 GMPR1_RAT 95.640 0.991329 1.0029 Gmpr - GMP reductase 1 - Rattus norvegicus (Rat) - Gmpr gene Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Indicus|evm.model.CM009513.1.609 Q8WY64 MYLIP_HUMAN 95.281 0.995516 1.00225 MYLIP - E3 ubiquitin-protein ligase MYLIP - Homo sapiens (Human) - MYLIP gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. Indicus|evm.model.CM009513.1.610 Q2HJA5 DTBP1_BOVIN 99.692 0.835052 1.1345 DTNBP1 - Dysbindin - Bos taurus (Bovine) - DTNBP1 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway (By similarity). Indicus|evm.model.CM009513.1.611 Q92833 JARD2_HUMAN 92.817 0.995958 0.992777 JARID2 - Protein Jumonji - Homo sapiens (Human) - JARID2 gene Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). Indicus|evm.model.CM009513.1.612 Q9WVF8 TUSC2_MOUSE 52.055 0.742268 0.881818 Tusc2 - Tumor suppressor candidate 2 - Mus musculus (Mouse) - Tusc2 gene mitochondrion, cell maturation, defense response to Gram-negative bacterium, inflammatory response, natural killer cell differentiation, negative regulation of interleukin-17 production, neutrophil-mediated killing of gram-negative bacterium, phagocytosis, positive regulation of interleukin-10 production, regulation of mitochondrial membrane potential Indicus|evm.model.CM009513.1.613 Q01151 CD83_HUMAN 74.146 0.99 0.97561 CD83 - CD83 antigen precursor - Homo sapiens (Human) - CD83 gene May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. Indicus|evm.model.CM009513.1.614 D3ZBM4 RN182_RAT 93.496 0.98 1.01215 Rnf182 - E3 ubiquitin-protein ligase RNF182 - Rattus norvegicus (Rat) - Rnf182 gene E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. Indicus|evm.model.CM009513.1.616 Q96AQ8 MCUR1_HUMAN 88.235 0.932203 0.657382 MCUR1 - Mitochondrial calcium uniporter regulator 1 - Homo sapiens (Human) - MCUR1 gene Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883). Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846). Indicus|evm.model.CM009513.1.617 Q96S59 RANB9_HUMAN 95.273 0.969912 0.775034 RANBP9 - Ran-binding protein 9 - Homo sapiens (Human) - RANBP9 gene May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. Indicus|evm.model.CM009513.1.618 Q9UMY1 NOL7_HUMAN 87.160 0.988372 1.00389 NOL7 - Nucleolar protein 7 - Homo sapiens (Human) - NOL7 gene chromosome, mitochondrion, nucleolus, RNA binding Indicus|evm.model.CM009513.1.619 Q3ZBQ0 SIR5_BOVIN 99.677 0.993569 1.00323 SIRT5 - NAD-dependent protein deacylase sirtuin-5, mitochondrial precursor - Bos taurus (Bovine) - SIRT5 gene NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. Indicus|evm.model.CM009513.1.620 Q3UHD2 GFOD1_MOUSE 100.000 0.965517 0.223077 Gfod1 - Glucose-fructose oxidoreductase domain-containing protein 1 precursor - Mus musculus (Mouse) - Gfod1 gene Indicus|evm.model.CM009513.1.621 Q9NXC2 GFOD1_HUMAN 99.552 0.991071 0.574359 GFOD1 - Glucose-fructose oxidoreductase domain-containing protein 1 precursor - Homo sapiens (Human) - GFOD1 gene Indicus|evm.model.CM009513.1.622 Q5E9C4 TBCD7_BOVIN 99.317 0.993197 1.00341 TBC1D7 - TBC1 domain family member 7 - Bos taurus (Bovine) - TBC1D7 gene Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question (By similarity). Indicus|evm.model.CM009513.1.623 Q9C0D0 PHAR1_HUMAN 83.951 0.927869 1.05172 PHACTR1 - Phosphatase and actin regulator 1 - Homo sapiens (Human) - PHACTR1 gene Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). Indicus|evm.model.CM009513.1.624 O15439 MRP4_HUMAN 77.711 0.987952 0.125283 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Indicus|evm.model.CM009513.1.625 P17322 EDN1_BOVIN 100.000 0.990148 1.00495 EDN1 - Endothelin-1 precursor - Bos taurus (Bovine) - EDN1 gene Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Indicus|evm.model.CM009513.1.626 Q1JQB5 FBLI1_BOVIN 100.000 0.216561 0.415344 FBLIM1 - Filamin-binding LIM protein 1 - Bos taurus (Bovine) - FBLIM1 gene Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). Indicus|evm.model.CM009513.1.627 Q5T1R4 ZEP3_HUMAN 80.000 0.0256983 1.11596 HIVEP3 - Transcription factor HIVEP3 - Homo sapiens (Human) - HIVEP3 gene Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. Indicus|evm.model.CM009513.1.629 Q96IZ2 ADTRP_HUMAN 63.478 0.989848 0.856522 ADTRP - Androgen-dependent TFPI-regulating protein - Homo sapiens (Human) - ADTRP gene Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574). Indicus|evm.model.CM009513.1.630 Q5T4T1 T170B_HUMAN 88.235 0.92126 0.962121 TMEM170B - Transmembrane protein 170B - Homo sapiens (Human) - TMEM170B gene Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets (PubMed:29367600). Indicus|evm.model.CM009513.1.631 Q14511 CASL_HUMAN 83.952 0.997585 0.992806 NEDD9 - Enhancer of filamentation 1 - Homo sapiens (Human) - NEDD9 gene Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Required for correct adhesion and migration of T-cells (PubMed:17174122). Indicus|evm.model.CM009513.1.632 Q9NXB9 ELOV2_HUMAN 91.398 0.992806 0.939189 ELOVL2 - Elongation of very long chain fatty acids protein 2 - Homo sapiens (Human) - ELOVL2 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Indicus|evm.model.CM009513.1.633 Q5T4T6 SYC2L_HUMAN 62.676 0.884013 1.17857 SYCP2L - Synaptonemal complex protein 2-like - Homo sapiens (Human) - SYCP2L gene Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes. Indicus|evm.model.CM009513.1.634 O75603 GCM2_HUMAN 72.781 0.996063 1.00395 GCM2 - Chorion-specific transcription factor GCMb - Homo sapiens (Human) - GCM2 gene Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development. Indicus|evm.model.CM009513.1.635 P20794 MAK_HUMAN 83.642 0.996918 1.04173 MAK - Serine/threonine-protein kinase MAK - Homo sapiens (Human) - MAK gene Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. Indicus|evm.model.CM009513.1.636 Q3ZCI1 TM14C_BOVIN 99.123 0.982609 1.00877 TMEM14C - Transmembrane protein 14C - Bos taurus (Bovine) - TMEM14C gene Required for normal heme biosynthesis. Indicus|evm.model.CM009513.1.637 Q5EA99 PK1IP_BOVIN 98.715 0.994872 0.994898 PAK1IP1 - p21-activated protein kinase-interacting protein 1 - Bos taurus (Bovine) - PAK1IP1 gene Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. Indicus|evm.model.CM009513.1.638 Q5T4I8 CF052_HUMAN 48.571 0.646667 0.986842 C6orf52 - Putative uncharacterized protein C6orf52 - Homo sapiens (Human) - C6orf52 gene Indicus|evm.model.CM009513.1.639 P97402 GCNT2_MOUSE 78.485 0.970414 0.842893 Gcnt2 - N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase - Mus musculus (Mouse) - Gcnt2 gene Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. Indicus|evm.model.CM009513.1.640 P97402 GCNT2_MOUSE 79.808 0.965839 0.802993 Gcnt2 - N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase - Mus musculus (Mouse) - Gcnt2 gene Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. Indicus|evm.model.CM009513.1.641 Q8N0V5 GNT2A_HUMAN 84.470 0.431148 1.51741 GCNT2 - N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase - Homo sapiens (Human) - GCNT2 gene Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. Indicus|evm.model.CM009513.1.643 A1A4R9 AP2A_BOVIN 100.000 0.990909 1.00686 TFAP2A - Transcription factor AP-2-alpha - Bos taurus (Bovine) - TFAP2A gene Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region (By similarity). Indicus|evm.model.CM009513.1.644 B0BK70 OFCC1_CHICK 76.543 0.467836 0.730769 OFCC1 - Orofacial cleft 1 candidate gene 1 protein homolog - Gallus gallus (Chicken) - OFCC1 gene perinuclear region of cytoplasm Indicus|evm.model.CM009513.1.647 Q5R831 S35B3_PONAB 91.022 0.925754 1.07481 SLC35B3 - Adenosine 3'-phospho 5'-phosphosulfate transporter 2 - Pongo abelii (Sumatran orangutan) - SLC35B3 gene Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon (By similarity). Indicus|evm.model.CM009513.1.649 O43324 MCA3_HUMAN 96.532 0.982857 1.00575 EEF1E1 - Eukaryotic translation elongation factor 1 epsilon-1 - Homo sapiens (Human) - EEF1E1 gene Positive modulator of ATM response to DNA damage. Indicus|evm.model.CM009513.1.650 A5A777 BL1S5_PIG 86.387 0.989529 1 BLOC1S5 - Biogenesis of lysosome-related organelles complex 1 subunit 5 - Sus scrofa (Pig) - BLOC1S5 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (By similarity). Indicus|evm.model.CM009513.1.651 Q91W90 TXND5_MOUSE 87.037 0.697368 0.182254 Txndc5 - Thioredoxin domain-containing protein 5 precursor - Mus musculus (Mouse) - Txndc5 gene Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast. Indicus|evm.model.CM009513.1.652 Q8NBS9 TXND5_HUMAN 87.826 0.991342 0.534722 TXNDC5 - Thioredoxin domain-containing protein 5 precursor - Homo sapiens (Human) - TXNDC5 gene Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). Indicus|evm.model.CM009513.1.653 Q04906 BMP6_RAT 85.149 0.993976 0.98419 Bmp6 - Bone morphogenetic protein 6 precursor - Rattus norvegicus (Rat) - Bmp6 gene Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (By similarity). Plays also an important role in the regulation of iron metabolism by acting as a ligand for hemojuvelin/HJV (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (By similarity). Indicus|evm.model.CM009513.1.654 Q6B860 RT14_BOVIN 90.625 0.984496 1.00781 MRPS14 - 28S ribosomal protein S14, mitochondrial - Bos taurus (Bovine) - MRPS14 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit, structural constituent of ribosome, mitochondrial translation, translation Indicus|evm.model.CM009513.1.655 Q6IEG0 SNR48_HUMAN 86.471 0.994135 1.0059 SNRNP48 - U11/U12 small nuclear ribonucleoprotein 48 kDa protein - Homo sapiens (Human) - SNRNP48 gene Likely involved in U12-type 5' splice site recognition. Indicus|evm.model.CM009513.1.656 P15924 DESP_HUMAN 93.977 0.999308 1.00662 DSP - Desmoplakin - Homo sapiens (Human) - DSP gene Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Indicus|evm.model.CM009513.1.657 Q9BRS2 RIOK1_HUMAN 88.732 0.996485 1.00176 RIOK1 - Serine/threonine-protein kinase RIO1 - Homo sapiens (Human) - RIOK1 gene Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). Indicus|evm.model.CM009513.1.658 Q8TC20 CAGE1_HUMAN 66.279 0.10111 1.04376 CAGE1 - Cancer-associated gene 1 protein - Homo sapiens (Human) - CAGE1 gene Indicus|evm.model.CM009513.1.659 A6QLP7 SSRA_BOVIN 100.000 0.969388 1.02797 SSR1 - Translocon-associated protein subunit alpha precursor - Bos taurus (Bovine) - SSR1 gene TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins (By similarity). Indicus|evm.model.CM009513.1.660 Q92766 RREB1_HUMAN 74.579 0.927594 1.03972 RREB1 - Ras-responsive element-binding protein 1 - Homo sapiens (Human) - RREB1 gene Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:9305772, PubMed:15067362, PubMed:8816445, PubMed:10390538, PubMed:17550981). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). Indicus|evm.model.CM009513.1.665 O95711 LY86_HUMAN 69.136 0.9875 0.987654 LY86 - Lymphocyte antigen 86 precursor - Homo sapiens (Human) - LY86 gene May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity). Indicus|evm.model.CM009513.1.666 P12260 F13A_BOVIN 100.000 0.25853 3.84848 F13A1 - Coagulation factor XIII A chain precursor - Bos taurus (Bovine) - F13A1 gene Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Indicus|evm.model.CM009513.1.668 Q7ZUB2 RS17_COTJA 53.571 0.490909 0.814815 RPS17 - 40S ribosomal protein S17 - Coturnix japonica (Japanese quail) - RPS17 gene Indicus|evm.model.CM009513.1.669 Q2KIC6 NRN1_BOVIN 100.000 0.986014 1.00704 NRN1 - Neuritin precursor - Bos taurus (Bovine) - NRN1 gene Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. Indicus|evm.model.CM009513.1.670 Q96KB5 TOPK_HUMAN 80.925 0.813397 0.649068 PBK - Lymphokine-activated killer T-cell-originated protein kinase - Homo sapiens (Human) - PBK gene Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Indicus|evm.model.CM009513.1.671 O95363 SYFM_HUMAN 84.922 0.995526 0.991131 FARS2 - Phenylalanine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - FARS2 gene Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. Indicus|evm.model.CM009513.1.672 Q0VCG0 LYRM4_BOVIN 96.875 0.212329 1.6044 LYRM4 - LYR motif-containing protein 4 - Bos taurus (Bovine) - LYRM4 gene Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. Indicus|evm.model.CM009513.1.673 O00560 SDCB1_HUMAN 90.659 0.978378 0.620805 SDCBP - Syntenin-1 - Homo sapiens (Human) - SDCBP gene Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). Indicus|evm.model.CM009513.1.674 Q0VCG0 LYRM4_BOVIN 95.556 0.229947 2.05495 LYRM4 - LYR motif-containing protein 4 - Bos taurus (Bovine) - LYRM4 gene Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. Indicus|evm.model.CM009513.1.677 A7YWU3 RPP40_BOVIN 99.010 0.82967 1.20132 RPP40 - Ribonuclease P protein subunit p40 - Bos taurus (Bovine) - RPP40 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Indicus|evm.model.CM009513.1.679 Q9Y232 CDYL_HUMAN 95.631 0.995157 0.690635 CDYL - Chromodomain Y-like protein - Homo sapiens (Human) - CDYL gene Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). Indicus|evm.model.CM009513.1.680 Q9Y232 CDYL_HUMAN 94.318 0.798165 0.182274 CDYL - Chromodomain Y-like protein - Homo sapiens (Human) - CDYL gene Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). Indicus|evm.model.CM009513.1.682 A6QLH5 ERI3_BOVIN 57.812 0.977273 0.261128 ERI3 - ERI1 exoribonuclease 3 - Bos taurus (Bovine) - ERI3 gene 3'-5'-exoribonuclease activity, DNA catabolic process, exonucleolytic, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009513.1.686 O75521 ECI2_HUMAN 76.602 0.994444 0.913706 ECI2 - Enoyl-CoA delta isomerase 2 precursor - Homo sapiens (Human) - ECI2 gene Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates. Indicus|evm.model.CM009513.1.687 Q95JI7 CF201_MACFA 71.707 0.918919 0.956897 QtsA-17053 - Uncharacterized protein C6orf201 homolog - Macaca fascicularis (Crab-eating macaque) - QtsA-17053 gene Indicus|evm.model.CM009513.1.688 Q8IXS0 F217A_HUMAN 61.010 0.844021 1.13583 FAM217A - Protein FAM217A - Homo sapiens (Human) - FAM217A gene Indicus|evm.model.CM009513.1.689 Q08DZ2 PRP4B_BOVIN 99.901 0.941121 1.06151 PRPF4B - Serine/threonine-protein kinase PRP4 homolog - Bos taurus (Bovine) - PRPF4B gene Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (By similarity). Indicus|evm.model.CM009513.1.693 Q08D85 PXDC1_BOVIN 99.567 0.991379 1.00433 PXDC1 - PX domain-containing protein 1 - Bos taurus (Bovine) - PXDC1 gene Indicus|evm.model.CM009513.1.698 Q9QZG1 S22AN_RAT 92.222 0.42381 0.30479 Slc22a23 - Solute carrier family 22 member 23 - Rattus norvegicus (Rat) - Slc22a23 gene Indicus|evm.model.CM009513.1.699 A1A5C7 S22AN_HUMAN 90.551 0.909091 0.609329 SLC22A23 - Solute carrier family 22 member 23 - Homo sapiens (Human) - SLC22A23 gene Indicus|evm.model.CM009513.1.701 Q5JS54 PSMG4_HUMAN 86.992 0.983871 1.00813 PSMG4 - Proteasome assembly chaperone 4 - Homo sapiens (Human) - PSMG4 gene Chaperone protein which promotes assembly of the 20S proteasome. Indicus|evm.model.CM009513.1.702 Q3KRE8 TBB2B_RAT 100.000 0.995516 1.00225 Tubb2b - Tubulin beta-2B chain - Rattus norvegicus (Rat) - Tubb2b gene Tubulin is the major constituent of microtubules (PubMed:19465910). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration (By similarity). Indicus|evm.model.CM009513.1.703 P09203 TBB1_CHICK 83.696 0.352713 0.579775 Tubulin beta-1 chain - Gallus gallus (Chicken) Indicus|evm.model.CM009513.1.704 P85108 TBB2A_RAT 100.000 0.995516 1.00225 Tubb2a - Tubulin beta-2A chain - Rattus norvegicus (Rat) - Tubb2a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Indicus|evm.model.CM009513.1.705 Q86WA6 BPHL_HUMAN 36.111 0.54386 0.979381 BPHL - Valacyclovir hydrolase precursor - Homo sapiens (Human) - BPHL gene Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Indicus|evm.model.CM009513.1.706 Q13546 RIPK1_HUMAN 74.813 0.996997 0.992548 RIPK1 - Receptor-interacting serine/threonine-protein kinase 1 - Homo sapiens (Human) - RIPK1 gene Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:31827280, PubMed:31827281). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591, PubMed:15310755). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). Indicus|evm.model.CM009513.1.707 Q5RBB9 NQO2_PONAB 81.385 0.991379 1.00433 NQO2 - Ribosyldihydronicotinamide dehydrogenase [quinone] - Pongo abelii (Sumatran orangutan) - NQO2 gene The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Indicus|evm.model.CM009513.1.709 O02739 SPB6_BOVIN 88.624 0.994723 1.00265 SERPINB6 - Serpin B6 - Bos taurus (Bovine) - SERPINB6 gene Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress (By similarity). May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Indicus|evm.model.CM009513.1.710 O02739 SPB6_BOVIN 83.862 0.994723 1.00265 SERPINB6 - Serpin B6 - Bos taurus (Bovine) - SERPINB6 gene Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress (By similarity). May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Indicus|evm.model.CM009513.1.711 O02739 SPB6_BOVIN 80.688 0.994709 1 SERPINB6 - Serpin B6 - Bos taurus (Bovine) - SERPINB6 gene Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress (By similarity). May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Indicus|evm.model.CM009513.1.712 O02739 SPB6_BOVIN 100.000 0.32439 1.08466 SERPINB6 - Serpin B6 - Bos taurus (Bovine) - SERPINB6 gene Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress (By similarity). May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Indicus|evm.model.CM009513.1.713 P50453 SPB9_HUMAN 67.819 0.994667 0.99734 SERPINB9 - Serpin B9 - Homo sapiens (Human) - SERPINB9 gene Granzyme B inhibitor. Indicus|evm.model.CM009513.1.714 Q1JPB0 ILEU_BOVIN 99.187 0.768025 0.846154 SERPINB1 - Leukocyte elastase inhibitor - Bos taurus (Bovine) - SERPINB1 gene Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function. Indicus|evm.model.CM009513.1.715 Q1JPB0 ILEU_BOVIN 97.143 0.827381 0.445623 SERPINB1 - Leukocyte elastase inhibitor - Bos taurus (Bovine) - SERPINB1 gene Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function. Indicus|evm.model.CM009513.1.716 Q91XU0 WRIP1_MOUSE 89.655 0.995413 0.660606 Wrnip1 - ATPase WRNIP1 - Mus musculus (Mouse) - Wrnip1 gene Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS. Indicus|evm.model.CM009513.1.717 Q86YV6 MYLK4_HUMAN 43.243 0.635294 0.438144 MYLK4 - Myosin light chain kinase family member 4 - Homo sapiens (Human) - MYLK4 gene myosin light chain kinase activity Indicus|evm.model.CM009513.1.718 Q86YV6 MYLK4_HUMAN 92.203 0.431718 1.75515 MYLK4 - Myosin light chain kinase family member 4 - Homo sapiens (Human) - MYLK4 gene myosin light chain kinase activity Indicus|evm.model.CM009513.1.723 O60547 GMDS_HUMAN 97.865 0.877743 0.857527 GMDS - GDP-mannose 4,6 dehydratase - Homo sapiens (Human) - GMDS gene Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. Indicus|evm.model.CM009513.1.727 Q61572 FOXC1_MOUSE 92.784 0.231527 0.734177 Foxc1 - Forkhead box protein C1 - Mus musculus (Mouse) - Foxc1 gene DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:9635428, PubMed:9106663, PubMed:10479458, PubMed:10395790, PubMed:11562355, PubMed:18187037, PubMed:19668217, PubMed:22493429, PubMed:24590069, PubMed:25808752, PubMed:28223138). Acts either as a transcriptional activator or repressor (PubMed:28223138). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:25808752). Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator (PubMed:25808752). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (PubMed:25808752). Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (PubMed:28223138). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (By similarity). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (PubMed:18187037). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (By similarity). Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage (PubMed:9106663, PubMed:10479458, PubMed:10395790, PubMed:10704385, PubMed:11562355, PubMed:15196959). Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC) (PubMed:24590069). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner (PubMed:22171010). May function as a tumor suppressor (By similarity). Indicus|evm.model.CM009513.1.728 Q61080 FOXF1_MOUSE 94.231 0.276882 0.984127 Foxf1 - Forkhead box protein F1 - Mus musculus (Mouse) - Foxf1 gene Probable transcription activator for a number of lung-specific genes. Indicus|evm.model.CM009513.1.735 Q96KP1 EXOC2_HUMAN 90.801 0.997838 1.00108 EXOC2 - Exocyst complex component 2 - Homo sapiens (Human) - EXOC2 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Indicus|evm.model.CM009513.1.736 Q15306 IRF4_HUMAN 93.570 0.995565 1 IRF4 - Interferon regulatory factor 4 - Homo sapiens (Human) - IRF4 gene Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). Indicus|evm.model.CM009513.1.737 Q9NRW4 DUS22_HUMAN 83.784 0.867925 1.15217 DUSP22 - Dual specificity protein phosphatase 22 - Homo sapiens (Human) - DUSP22 gene Activates the Jnk signaling pathway. Indicus|evm.model.CM009513.1.740 Q13136 LIPA1_HUMAN 58.763 0.849112 0.281198 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009513.1.741 Q8NGL7 OR4P4_HUMAN 66.272 0.933333 0.576923 OR4P4 - Olfactory receptor 4P4 - Homo sapiens (Human) - OR4P4 gene Odorant receptor. Indicus|evm.model.CM009514.1.1 Q9UPS8 ANR26_HUMAN 50.000 0.928115 0.366082 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009514.1.2 Q13136 LIPA1_HUMAN 80.882 0.462069 0.120632 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009514.1.3 Q8VFK7 O1020_MOUSE 56.502 0.96087 0.725552 Olfr1020 - Olfactory receptor 1020 - Mus musculus (Mouse) - Olfr1020 gene Potential odorant receptor. Indicus|evm.model.CM009514.1.5 Q9BYG4 PAR6G_HUMAN 80.737 0.983003 0.93883 PARD6G - Partitioning defective 6 homolog gamma - Homo sapiens (Human) - PARD6G gene Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Indicus|evm.model.CM009514.1.6 Q6IQ32 ADNP2_HUMAN 84.522 0.995641 1.01415 ADNP2 - Activity-dependent neuroprotector homeobox protein 2 - Homo sapiens (Human) - ADNP2 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009514.1.8 Q8N0V3 RBFA_HUMAN 65.033 0.993174 0.854227 RBFA - Putative ribosome-binding factor A, mitochondrial precursor - Homo sapiens (Human) - RBFA gene Indicus|evm.model.CM009514.1.9 Q9C4M5 GYAR_THELN 45.522 0.706199 1.12085 gyaR - Glyoxylate reductase - Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) - gyaR gene Indicus|evm.model.CM009514.1.10 P83877 TXN4A_MOUSE 99.296 0.723077 1.37324 Txnl4a - Thioredoxin-like protein 4A - Mus musculus (Mouse) - Txnl4a gene Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). Indicus|evm.model.CM009514.1.11 C9JCN9 HSBPL_HUMAN 56.436 0.561798 2.40541 HSBP1L1 - Heat shock factor-binding protein 1-like protein 1 - Homo sapiens (Human) - HSBP1L1 gene cytosol, nucleus, cellular heat acclimation Indicus|evm.model.CM009514.1.12 Q0VCC1 S66A2_BOVIN 73.408 0.992424 1.04348 SLC66A2 - Solute carrier family 66 member 2 - Bos taurus (Bovine) - SLC66A2 gene endosome, trans-Golgi network, phospholipid translocation, retrograde transport, endosome to Golgi Indicus|evm.model.CM009514.1.13 Q9UJ96 KCNG2_HUMAN 91.584 0.851695 0.506438 KCNG2 - Potassium voltage-gated channel subfamily G member 2 - Homo sapiens (Human) - KCNG2 gene Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Indicus|evm.model.CM009514.1.14 Q7TSG2 CTDP1_MOUSE 68.191 0.997863 0.975 Ctdp1 - RNA polymerase II subunit A C-terminal domain phosphatase - Mus musculus (Mouse) - Ctdp1 gene Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation (By similarity). Indicus|evm.model.CM009514.1.18 P98201 NFAC1_BOVIN 100.000 0.876503 1.13948 NFATC1 - Nuclear factor of activated T-cells, cytoplasmic 1 - Bos taurus (Bovine) - NFATC1 gene Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). Indicus|evm.model.CM009514.1.19 A1A4J6 ATP9B_BOVIN 100.000 0.998241 1.00088 ATP9B - Probable phospholipid-transporting ATPase IIB - Bos taurus (Bovine) - ATP9B gene endosome, plasma membrane, trans-Golgi network, ATPase-coupled intramembrane lipid transporter activity, endocytosis, phospholipid translocation, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Indicus|evm.model.CM009514.1.20 Q62255 SALL3_MOUSE 84.494 0.894687 0.798485 Sall3 - Sal-like protein 3 - Mus musculus (Mouse) - Sall3 gene Probable transcription factor. Indicus|evm.model.CM009514.1.30 P47211 GALR1_HUMAN 92.837 0.994286 1.00287 GALR1 - Galanin receptor type 1 - Homo sapiens (Human) - GALR1 gene Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Indicus|evm.model.CM009514.1.31 P02688 MBP_RAT 82.412 0.484211 1.94872 Mbp - Myelin basic protein - Rattus norvegicus (Rat) - Mbp gene Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). Indicus|evm.model.CM009514.1.32 Q9UL36 ZN236_HUMAN 77.392 0.998922 1.00596 ZNF236 - Zinc finger protein 236 - Homo sapiens (Human) - ZNF236 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009514.1.34 Q7TSH3 ZN516_MOUSE 79.167 0.449795 0.843561 Znf516 - Zinc finger protein 516 - Mus musculus (Mouse) - Znf516 gene Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress (By similarity). Indicus|evm.model.CM009514.1.39 Q6ZSZ6 TSH1_HUMAN 85.834 0.998117 0.986072 TSHZ1 - Teashirt homolog 1 - Homo sapiens (Human) - TSHZ1 gene Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Indicus|evm.model.CM009514.1.41 Q24K16 PTGR3_BOVIN 100.000 0.910714 0.891247 ZADH2 - Prostaglandin reductase-3 - Bos taurus (Bovine) - ZADH2 gene Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Indicus|evm.model.CM009514.1.43 Q9C0G0 ZN407_HUMAN 77.027 0.915433 0.210409 ZNF407 - Zinc finger protein 407 - Homo sapiens (Human) - ZNF407 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009514.1.44 Q9C0G0 ZN407_HUMAN 71.366 0.998313 0.790925 ZNF407 - Zinc finger protein 407 - Homo sapiens (Human) - ZNF407 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009514.1.45 Q96KN2 CNDP1_HUMAN 82.073 0.847706 1.07495 CNDP1 - Beta-Ala-His dipeptidase precursor - Homo sapiens (Human) - CNDP1 gene cytosol, dipeptidase activity, peptidase activity, proteolysis, regulation of cellular protein metabolic process Indicus|evm.model.CM009514.1.46 Q3ZC84 CNDP2_BOVIN 99.789 0.995798 1.00211 CNDP2 - Cytosolic non-specific dipeptidase - Bos taurus (Bovine) - CNDP2 gene Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis. Indicus|evm.model.CM009514.1.47 Q0P6D2 DIK1C_HUMAN 69.291 0.542986 0.527446 DIPK1C - Divergent protein kinase domain 1C - Homo sapiens (Human) - DIPK1C gene Indicus|evm.model.CM009514.1.48 Q68DL7 CR063_HUMAN 61.325 0.914286 1.0219 C18orf63 - Uncharacterized protein C18orf63 - Homo sapiens (Human) - C18orf63 gene Indicus|evm.model.CM009514.1.49 P00171 CYB5_BOVIN 100.000 0.985185 1.00746 CYB5A - Cytochrome b5 - Bos taurus (Bovine) - CYB5A gene Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. Indicus|evm.model.CM009514.1.51 Q3SZV6 TIM21_BOVIN 98.770 0.991837 1.0041 TIMM21 - Mitochondrial import inner membrane translocase subunit Tim21 precursor - Bos taurus (Bovine) - TIMM21 gene Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. Indicus|evm.model.CM009514.1.52 Q3SYW0 FBX15_BOVIN 90.773 0.895397 1.02575 FBXO15 - F-box only protein 15 - Bos taurus (Bovine) - FBXO15 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009514.1.54 Q8TDF5 NETO1_HUMAN 96.755 0.960227 0.660413 NETO1 - Neuropilin and tolloid-like protein 1 precursor - Homo sapiens (Human) - NETO1 gene Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity). Indicus|evm.model.CM009514.1.55 Q8IUK8 CBLN2_HUMAN 97.126 0.940217 0.821429 CBLN2 - Cerebellin-2 precursor - Homo sapiens (Human) - CBLN2 gene Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (By similarity). Indicus|evm.model.CM009514.1.57 Q5RCM6 SOCS6_PONAB 97.462 0.606811 0.603738 SOCS6 - Suppressor of cytokine signaling 6 - Pongo abelii (Sumatran orangutan) - SOCS6 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity). Indicus|evm.model.CM009514.1.58 Q86VV8 RTTN_HUMAN 83.453 0.999103 1.0018 RTTN - Rotatin - Homo sapiens (Human) - RTTN gene Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2. Indicus|evm.model.CM009514.1.59 O18906 CD226_MACMU 52.367 0.993377 0.89881 CD226 - CD226 antigen precursor - Macaca mulatta (Rhesus macaque) - CD226 gene Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding. Indicus|evm.model.CM009514.1.60 Q2MHE5 DOK6_MOUSE 91.304 0.381356 0.356495 Dok6 - Docking protein 6 - Mus musculus (Mouse) - Dok6 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance (By similarity). Indicus|evm.model.CM009514.1.62 Q6PKX4 DOK6_HUMAN 99.474 0.670213 0.851964 DOK6 - Docking protein 6 - Homo sapiens (Human) - DOK6 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. Indicus|evm.model.CM009514.1.64 Q5R875 TMX3_PONAB 88.987 0.995604 1.0022 TMX3 - Protein disulfide-isomerase TMX3 precursor - Pongo abelii (Sumatran orangutan) - TMX3 gene Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase (By similarity). Indicus|evm.model.CM009514.1.67 Q8IZU8 DSEL_HUMAN 90.017 0.998351 1.00083 DSEL - Dermatan-sulfate epimerase-like protein precursor - Homo sapiens (Human) - DSEL gene Golgi membrane, chondroitin-glucuronate 5-epimerase activity, chondroitin sulfate metabolic process, dermatan sulfate biosynthetic process, dermatan sulfate metabolic process Indicus|evm.model.CM009514.1.68 Q9H159 CAD19_HUMAN 85.695 0.997245 0.940415 CDH19 - Cadherin-19 precursor - Homo sapiens (Human) - CDH19 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009514.1.69 Q9ULB5 CADH7_HUMAN 98.089 0.997455 1.00127 CDH7 - Cadherin-7 precursor - Homo sapiens (Human) - CDH7 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009514.1.71 Q5BIR5 SPB8_BOVIN 100.000 0.994667 1.00267 SERPINB8 - Serpin B8 - Bos taurus (Bovine) - SERPINB8 gene Has an important role in epithelial desmosome-mediated cell-cell adhesion. Indicus|evm.model.CM009514.1.72 A5PJK0 SPB10_BOVIN 90.598 0.983051 0.297229 SERPINB10 - Serpin B10 - Bos taurus (Bovine) - SERPINB10 gene Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). Indicus|evm.model.CM009514.1.73 P05120 PAI2_HUMAN 79.087 0.995204 1.00482 SERPINB2 - Plasminogen activator inhibitor 2 precursor - Homo sapiens (Human) - SERPINB2 gene Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Indicus|evm.model.CM009514.1.74 P62246 RS15A_RAT 97.692 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Indicus|evm.model.CM009514.1.75 Q9H2B2 SYT4_HUMAN 92.471 0.995305 1.00235 SYT4 - Synaptotagmin-4 - Homo sapiens (Human) - SYT4 gene Synaptotagmin family member which does not bind Ca(2+) (PubMed:23999003) (By similarity). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Indicus|evm.model.CM009514.1.76 Q58DQ3 RL6_BOVIN 99.652 0.993056 1.00348 RPL6 - 60S ribosomal protein L6 - Bos taurus (Bovine) - RPL6 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009514.1.77 Q9H446 RWDD1_HUMAN 72.321 0.866667 0.864198 RWDD1 - RWD domain-containing protein 1 - Homo sapiens (Human) - RWDD1 gene Protects DRG2 from proteolytic degradation. Indicus|evm.model.CM009514.1.78 Q8NEB9 PK3C3_HUMAN 99.098 0.997748 1.00113 PIK3C3 - Phosphatidylinositol 3-kinase catalytic subunit type 3 - Homo sapiens (Human) - PIK3C3 gene Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity). Indicus|evm.model.CM009514.1.79 Q9GMB0 RPN1_PIG 74.194 0.859155 0.116776 RPN1 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor - Sus scrofa (Pig) - RPN1 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (Probable). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Indicus|evm.model.CM009514.1.80 Q9Z222 B3GN2_MOUSE 91.228 0.982609 0.289673 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Mus musculus (Mouse) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains (PubMed:9892646). Probably constitutes the main polylactosamine synthase (PubMed:17890318). Indicus|evm.model.CM009514.1.83 Q96I25 SPF45_HUMAN 97.333 0.968912 0.962594 RBM17 - Splicing factor 45 - Homo sapiens (Human) - RBM17 gene Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. Indicus|evm.model.CM009514.1.86 Q4R535 CELF4_MACFA 83.193 0.936508 0.265823 CELF4 - CUGBP Elav-like family member 4 - Macaca fascicularis (Crab-eating macaque) - CELF4 gene RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Indicus|evm.model.CM009514.1.88 Q4R535 CELF4_MACFA 99.678 0.769231 0.850211 CELF4 - CUGBP Elav-like family member 4 - Macaca fascicularis (Crab-eating macaque) - CELF4 gene RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Indicus|evm.model.CM009514.1.89 Q86T90 K1328_HUMAN 64.120 0.995381 0.750433 KIAA1328 - Protein hinderin - Homo sapiens (Human) - KIAA1328 gene Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. Indicus|evm.model.CM009514.1.90 Q86T90 K1328_HUMAN 85.455 0.947826 0.199307 KIAA1328 - Protein hinderin - Homo sapiens (Human) - KIAA1328 gene Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. Indicus|evm.model.CM009514.1.91 Q68CL5 TPGS2_HUMAN 91.513 0.915254 0.983333 TPGS2 - Tubulin polyglutamylase complex subunit 2 - Homo sapiens (Human) - TPGS2 gene Indicus|evm.model.CM009514.1.92 Q2V2M9 FHOD3_HUMAN 94.500 0.336993 0.83263 FHOD3 - FH1/FH2 domain-containing protein 3 - Homo sapiens (Human) - FHOD3 gene Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. Indicus|evm.model.CM009514.1.93 Q9N0E7 MOCOS_BOVIN 100.000 0.997735 1.00113 MOCOS - Molybdenum cofactor sulfurase - Bos taurus (Bovine) - MOCOS gene Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. Indicus|evm.model.CM009514.1.94 Q6IA86 ELP2_HUMAN 87.923 0.990385 0.251816 ELP2 - Elongator complex protein 2 - Homo sapiens (Human) - ELP2 gene Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Indicus|evm.model.CM009514.1.95 Q6IA86 ELP2_HUMAN 86.654 0.893617 0.739709 ELP2 - Elongator complex protein 2 - Homo sapiens (Human) - ELP2 gene Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Indicus|evm.model.CM009514.1.96 Q5R9M9 S39A6_PONAB 91.700 0.997305 0.998654 SLC39A6 - Zinc transporter ZIP6 precursor - Pongo abelii (Sumatran orangutan) - SLC39A6 gene May act as a zinc-influx transporter. Indicus|evm.model.CM009514.1.97 Q5R8Y3 RPR1A_PONAB 100.000 0.99361 1.00321 RPRD1A - Regulation of nuclear pre-mRNA domain-containing protein 1A - Pongo abelii (Sumatran orangutan) - RPRD1A gene Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. Indicus|evm.model.CM009514.1.98 Q05B49 CR021_BOVIN 99.074 0.990783 1.00463 UPF0711 protein C18orf21 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009514.1.99 Q07537 GALT1_BOVIN 100.000 0.996429 1.00179 GALNT1 - Polypeptide N-acetylgalactosaminyltransferase 1 - Bos taurus (Bovine) - GALNT1 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. Indicus|evm.model.CM009514.1.100 Q6PI98 IN80C_HUMAN 94.271 0.989637 1.00521 INO80C - INO80 complex subunit C - Homo sapiens (Human) - INO80C gene Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Indicus|evm.model.CM009514.1.101 Q86W11 ZSC30_HUMAN 87.879 0.405063 0.159919 ZSCAN30 - Zinc finger and SCAN domain-containing protein 30 - Homo sapiens (Human) - ZSCAN30 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009514.1.102 Q5RAE6 ZNF24_PONAB 97.534 0.879227 1.125 ZNF24 - Zinc finger protein 24 - Pongo abelii (Sumatran orangutan) - ZNF24 gene Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro (By similarity). Indicus|evm.model.CM009514.1.103 Q5R5U3 ZN271_PONAB 87.132 0.975647 0.977679 ZNF271 - Zinc finger protein 271 - Pongo abelii (Sumatran orangutan) - ZNF271 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009514.1.104 Q86W11 ZSC30_HUMAN 68.231 0.886731 0.625506 ZSCAN30 - Zinc finger and SCAN domain-containing protein 30 - Homo sapiens (Human) - ZSCAN30 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009514.1.105 Q1LZ87 ZN397_BOVIN 100.000 0.996262 1.00187 ZNF397 - Zinc finger protein 397 - Bos taurus (Bovine) - ZNF397 gene DNA-dependent transcriptional repressor. Indicus|evm.model.CM009514.1.106 O15347 HMGB3_HUMAN 83.929 0.891892 0.925 HMGB3 - High mobility group protein B3 - Homo sapiens (Human) - HMGB3 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). Indicus|evm.model.CM009514.1.107 Q3SZP2 MARE2_BOVIN 100.000 0.905063 0.969325 MAPRE2 - Microtubule-associated protein RP/EB family member 2 - Bos taurus (Bovine) - MAPRE2 gene May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). Indicus|evm.model.CM009514.1.109 Q9Y4J8 DTNA_HUMAN 88.472 0.996974 0.889637 DTNA - Dystrobrevin alpha - Homo sapiens (Human) - DTNA gene May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. Indicus|evm.model.CM009514.1.110 Q58DE2 MSTRO_BOVIN 82.609 0.832117 0.520913 MRO - Protein maestro - Bos taurus (Bovine) - MRO gene Indicus|evm.model.CM009514.1.111 O94818 NOL4_HUMAN 97.479 0.997899 0.746082 NOL4 - Nucleolar protein 4 - Homo sapiens (Human) - NOL4 gene nucleolus, RNA binding Indicus|evm.model.CM009514.1.112 Q9C0F0 ASXL3_HUMAN 82.026 0.998971 0.864324 ASXL3 - Putative Polycomb group protein ASXL3 - Homo sapiens (Human) - ASXL3 gene Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Indicus|evm.model.CM009514.1.113 Q9C0F0 ASXL3_HUMAN 94.536 0.742739 0.107206 ASXL3 - Putative Polycomb group protein ASXL3 - Homo sapiens (Human) - ASXL3 gene Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Indicus|evm.model.CM009514.1.114 Q5BJE1 CC178_HUMAN 57.407 0.765766 1.02422 CCDC178 - Coiled-coil domain-containing protein 178 - Homo sapiens (Human) - CCDC178 gene ciliary basal body Indicus|evm.model.CM009514.1.115 Q9P2G3 KLH14_HUMAN 97.333 0.826816 0.570064 KLHL14 - Kelch-like protein 14 - Homo sapiens (Human) - KLHL14 gene actin cytoskeleton, aggresome, cytosol, endoplasmic reticulum, neuron projection, neuronal cell body Indicus|evm.model.CM009514.1.116 Q69ZK5 KLH14_MOUSE 92.256 0.960526 0.48254 Klhl14 - Kelch-like protein 14 - Mus musculus (Mouse) - Klhl14 gene actin cytoskeleton, aggresome, cytosol, endoplasmic reticulum, neuron projection, neuronal cell body Indicus|evm.model.CM009514.1.117 Q9H706 GARE1_HUMAN 90.531 0.827885 1.18721 GAREM1 - GRB2-associated and regulator of MAPK protein 1 - Homo sapiens (Human) - GAREM1 gene Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Indicus|evm.model.CM009514.1.118 Q16820 MEP1B_HUMAN 77.467 0.967143 0.998573 MEP1B - Meprin A subunit beta precursor - Homo sapiens (Human) - MEP1B gene Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Indicus|evm.model.CM009514.1.119 Q32LN5 RN138_BOVIN 100.000 0.757764 1.31429 RNF138 - E3 ubiquitin-protein ligase RNF138 - Bos taurus (Bovine) - RNF138 gene E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. Indicus|evm.model.CM009514.1.120 Q95KF1 RN125_MACFA 90.476 0.987124 1.00431 RNF125 - E3 ubiquitin-protein ligase RNF125 - Macaca fascicularis (Crab-eating macaque) - RNF125 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation. Indicus|evm.model.CM009514.1.121 Q9Y2L5 TPPC8_HUMAN 92.618 0.998571 0.97561 TRAPPC8 - Trafficking protein particle complex subunit 8 - Homo sapiens (Human) - TRAPPC8 gene Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Indicus|evm.model.CM009514.1.122 Q9UBX8 B4GT6_HUMAN 98.168 0.994778 1.00262 B4GALT6 - Beta-1,4-galactosyltransferase 6 - Homo sapiens (Human) - B4GALT6 gene Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:3099851, PubMed:1551920, PubMed:24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Indicus|evm.model.CM009514.1.123 O46375 TTHY_BOVIN 100.000 0.986486 1.0068 TTR - Transthyretin precursor - Bos taurus (Bovine) - TTR gene Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Indicus|evm.model.CM009514.1.124 Q14126 DSG2_HUMAN 75.605 0.997314 0.999106 DSG2 - Desmoglein-2 precursor - Homo sapiens (Human) - DSG2 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Indicus|evm.model.CM009514.1.125 Q7YRU7 DSG3_CANLF 79.598 0.997978 0.995972 DSG3 - Desmoglein-3 precursor - Canis lupus familiaris (Dog) - DSG3 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity). Indicus|evm.model.CM009514.1.126 Q86SJ6 DSG4_HUMAN 83.285 0.998053 0.9875 DSG4 - Desmoglein-4 precursor - Homo sapiens (Human) - DSG4 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). Indicus|evm.model.CM009514.1.127 Q03763 DSG1_BOVIN 97.699 0.998084 1.00096 DSG1 - Desmoglein-1 precursor - Bos taurus (Bovine) - DSG1 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Indicus|evm.model.CM009514.1.128 Q01107 DSC1_BOVIN 99.486 0.996154 0.87346 DSC1 - Desmocollin-1 precursor - Bos taurus (Bovine) - DSC1 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. Indicus|evm.model.CM009514.1.129 P33545 DSC2_BOVIN 99.073 0.947253 1.05446 DSC2 - Desmocollin-2 precursor - Bos taurus (Bovine) - DSC2 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Indicus|evm.model.CM009514.1.130 Q28060 DSC3_BOVIN 98.328 0.997773 1.00223 DSC3 - Desmocollin-3 precursor - Bos taurus (Bovine) - DSC3 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Indicus|evm.model.CM009514.1.131 P19534 CADH2_BOVIN 98.246 0.717949 0.0860927 CDH2 - Cadherin-2 precursor - Bos taurus (Bovine) - CDH2 gene Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Indicus|evm.model.CM009514.1.132 P19534 CADH2_BOVIN 94.346 0.99139 0.897351 CDH2 - Cadherin-2 precursor - Bos taurus (Bovine) - CDH2 gene Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Indicus|evm.model.CM009514.1.133 Q8NHP6 MSPD2_HUMAN 66.418 0.949772 0.42278 MOSPD2 - Motile sperm domain-containing protein 2 - Homo sapiens (Human) - MOSPD2 gene Endoplasmic reticulum-anchored receptor which modulates interorganelle contacts by interacting with other organelle-bound proteins via their FFAT motif (PubMed:29858488). Might have a more important role in endoplasmic reticulum and endosomes contacts (PubMed:29858488). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). Indicus|evm.model.CM009514.1.134 A5PJL1 PXMP4_BOVIN 92.925 0.946188 1.05189 PXMP4 - Peroxisomal membrane protein 4 - Bos taurus (Bovine) - PXMP4 gene peroxisomal membrane Indicus|evm.model.CM009514.1.135 Q7L1S5 CHST9_HUMAN 85.090 0.994859 0.878104 CHST9 - Carbohydrate sulfotransferase 9 - Homo sapiens (Human) - CHST9 gene Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin. Indicus|evm.model.CM009514.1.136 O77750 AQP4_BOVIN 100.000 0.978056 0.987616 AQP4 - Aquaporin-4 - Bos taurus (Bovine) - AQP4 gene Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability. Indicus|evm.model.CM009514.1.137 Q2HJ48 KCTD1_BOVIN 100.000 0.296984 3.35409 KCTD1 - BTB/POZ domain-containing protein KCTD1 - Bos taurus (Bovine) - KCTD1 gene May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. Indicus|evm.model.CM009514.1.138 Q92750 TAF4B_HUMAN 86.127 0.997688 1.00348 TAF4B - Transcription initiation factor TFIID subunit 4B - Homo sapiens (Human) - TAF4B gene Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. Indicus|evm.model.CM009514.1.139 Q4R7D9 PSA7L_MACFA 97.189 0.988048 1.004 PSMA7L - Proteasome subunit alpha type-7-like - Macaca fascicularis (Crab-eating macaque) - PSMA7L gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. Indicus|evm.model.CM009514.1.140 Q15532 SSXT_HUMAN 97.129 0.995215 1 SS18 - Protein SSXT - Homo sapiens (Human) - SS18 gene Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Indicus|evm.model.CM009514.1.141 Q28205 TBCD_BOVIN 67.816 0.924731 0.0775646 TBCD - Tubulin-specific chaperone D - Bos taurus (Bovine) - TBCD gene Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis. Indicus|evm.model.CM009514.1.143 Q96K83 ZN521_HUMAN 97.559 0.998476 1.00076 ZNF521 - Zinc finger protein 521 - Homo sapiens (Human) - ZNF521 gene Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. Indicus|evm.model.CM009514.1.144 A7YY45 IMPCT_BOVIN 99.662 0.324176 2.86164 IMPACT - Protein IMPACT - Bos taurus (Bovine) - IMPACT gene Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. Indicus|evm.model.CM009514.1.145 Q9BXW6 OSBL1_HUMAN 94.211 0.997897 1.00105 OSBPL1A - Oxysterol-binding protein-related protein 1 - Homo sapiens (Human) - OSBPL1A gene Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). Indicus|evm.model.CM009514.1.146 Q710D7 CABYR_VULVU 76.720 0.488251 0.769076 CABYR - Calcium-binding tyrosine phosphorylation-regulated protein - Vulpes vulpes (Red fox) - CABYR gene May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Binds calcium in vitro (By similarity). Indicus|evm.model.CM009514.1.147 Q8N584 TT39C_HUMAN 98.814 0.574032 0.753002 TTC39C - Tetratricopeptide repeat protein 39C - Homo sapiens (Human) - TTC39C gene cilium assembly, otolith morphogenesis Indicus|evm.model.CM009514.1.149 Q16787 LAMA3_HUMAN 83.388 0.29522 0.928893 LAMA3 - Laminin subunit alpha-3 precursor - Homo sapiens (Human) - LAMA3 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Indicus|evm.model.CM009514.1.150 Q8N6D5 ANR29_HUMAN 95.918 0.986532 0.986711 ANKRD29 - Ankyrin repeat domain-containing protein 29 - Homo sapiens (Human) - ANKRD29 gene Indicus|evm.model.CM009514.1.151 P56941 NPC1_PIG 91.073 0.998435 1.00078 NPC1 - NPC intracellular cholesterol transporter 1 precursor - Sus scrofa (Pig) - NPC1 gene Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Indicus|evm.model.CM009514.1.152 Q96DM3 RMC1_HUMAN 91.020 0.996875 0.974125 RMC1 - Regulator of MON1-CCZ1 complex - Homo sapiens (Human) - RMC1 gene Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162). Indicus|evm.model.CM009514.1.153 Q1RMT7 RIOK3_BOVIN 100.000 0.996154 1.00193 RIOK3 - Serine/threonine-protein kinase RIO3 - Bos taurus (Bovine) - RIOK3 gene Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 within the C-terminal region interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA. Indicus|evm.model.CM009514.1.154 Q24JQ0 TM241_HUMAN 71.622 0.991837 0.827703 TMEM241 - Transmembrane protein 241 - Homo sapiens (Human) - TMEM241 gene Golgi apparatus, antiporter activity Indicus|evm.model.CM009514.1.155 Q8TDN4 CABL1_HUMAN 95.413 0.977528 0.703002 CABLES1 - CDK5 and ABL1 enzyme substrate 1 - Homo sapiens (Human) - CABLES1 gene Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). Indicus|evm.model.CM009514.1.156 A6QNQ6 CTIP_BOVIN 99.469 0.846067 1.17569 RBBP8 - DNA endonuclease RBBP8 - Bos taurus (Bovine) - RBBP8 gene Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (By similarity). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Indicus|evm.model.CM009514.1.158 Q95JA5 GATA6_PIG 95.385 0.827476 0.694013 GATA6 - Transcription factor GATA-6 - Sus scrofa (Pig) - GATA6 gene Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Indicus|evm.model.CM009514.1.159 Q95JA5 GATA6_PIG 96.226 0.230088 0.501109 GATA6 - Transcription factor GATA-6 - Sus scrofa (Pig) - GATA6 gene Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Indicus|evm.model.CM009514.1.160 Q86YT6 MIB1_HUMAN 94.533 0.997908 0.950298 MIB1 - E3 ubiquitin-protein ligase MIB1 - Homo sapiens (Human) - MIB1 gene E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. Indicus|evm.model.CM009514.1.161 Q0VC00 ABHD3_BOVIN 70.283 0.99446 0.878345 ABHD3 - Phospholipase ABHD3 - Bos taurus (Bovine) - ABHD3 gene Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids. Indicus|evm.model.CM009514.1.162 P62315 SMD1_MOUSE 100.000 0.983333 1.0084 Snrpd1 - Small nuclear ribonucleoprotein Sm D1 - Mus musculus (Mouse) - Snrpd1 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. Indicus|evm.model.CM009514.1.164 Q5FWF5 ESCO1_HUMAN 83.943 0.997625 1.00238 ESCO1 - N-acetyltransferase ESCO1 - Homo sapiens (Human) - ESCO1 gene Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). Indicus|evm.model.CM009514.1.165 Q9C091 GRB1L_HUMAN 95.764 0.39807 0.862194 GREB1L - GREB1-like protein - Homo sapiens (Human) - GREB1L gene Plays a major role in early metanephros and genital development. Indicus|evm.model.CM009514.1.166 Q04941 PLP2_HUMAN 68.613 0.984733 0.861842 PLP2 - Proteolipid protein 2 - Homo sapiens (Human) - PLP2 gene May play a role in cell differentiation in the intestinal epithelium. Indicus|evm.model.CM009514.1.167 O77819 ROCK1_RABIT 97.932 0.998524 1.00074 ROCK1 - Rho-associated protein kinase 1 - Oryctolagus cuniculus (Rabbit) - ROCK1 gene Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity) (PubMed:9139666). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By similarity). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). Indicus|evm.model.CM009514.1.168 Q0IIF7 UBP14_BOVIN 92.713 0.995643 0.92915 USP14 - Ubiquitin carboxyl-terminal hydrolase 14 - Bos taurus (Bovine) - USP14 gene Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation. Indicus|evm.model.CM009514.1.169 Q96FV9 THOC1_HUMAN 97.565 0.99696 1.00152 THOC1 - THO complex subunit 1 - Homo sapiens (Human) - THOC1 gene Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. Indicus|evm.model.CM009514.1.170 A6QP79 COL12_BOVIN 100.000 0.997308 1.00135 COLEC12 - Collectin-12 - Bos taurus (Bovine) - COLEC12 gene Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) (By similarity). Indicus|evm.model.CM009514.1.171 Q32LE3 CETN1_BOVIN 100.000 0.988439 1.00581 CETN1 - Centrin-1 - Bos taurus (Bovine) - CETN1 gene Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (By similarity). Indicus|evm.model.CM009514.1.172 Q3ZRW9 CLUL1_BOVIN 99.355 0.995708 1.00215 CLUL1 - Clusterin-like protein 1 precursor - Bos taurus (Bovine) - CLUL1 gene extracellular space, nucleus, misfolded protein binding Indicus|evm.model.CM009514.1.173 P07607 TYSY_MOUSE 90.000 0.943218 1.03257 Tyms - Thymidylate synthase - Mus musculus (Mouse) - Tyms gene Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Indicus|evm.model.CM009514.1.174 Q2KIA9 ENOF1_BOVIN 99.774 0.995495 1.00226 ENOSF1 - Mitochondrial enolase superfamily member 1 - Bos taurus (Bovine) - ENOSF1 gene Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion. May down-regulate thymidylate synthase activity, possibly already at the RNA level, by promoting the degradation of TYMS mRNA via an antisense RNA-based mechanism. Indicus|evm.model.CM009514.1.175 P07947 YES_HUMAN 96.869 0.99631 0.998158 YES1 - Tyrosine-protein kinase Yes - Homo sapiens (Human) - YES1 gene Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Indicus|evm.model.CM009514.1.177 P16613 PACA_SHEEP 97.727 0.988701 1.00568 ADCYAP1 - Pituitary adenylate cyclase-activating polypeptide precursor - Ovis aries (Sheep) - ADCYAP1 gene Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). Indicus|evm.model.CM009514.1.178 P62630 EF1A1_RAT 79.233 0.992718 0.891775 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009514.1.180 Q5R538 FRIL_PONAB 47.778 0.688679 0.605714 FTL - Ferritin light chain - Pongo abelii (Sumatran orangutan) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009514.1.181 Q8N3J2 METL4_HUMAN 81.499 0.959276 0.936441 METTL4 - N(6)-adenine-specific methyltransferase METTL4 - Homo sapiens (Human) - METTL4 gene N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA (PubMed:31913360, PubMed:32183942). Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation (PubMed:31913360). Internal m6A(m) methylation of snRNAs regulates RNA splicing (PubMed:31913360). Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:32183942). The existence of N(6)-methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6)-adenine-specific DNA methyltransferase activity of METTL4 in vivo (PubMed:32203414). Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending (PubMed:32183942). N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity). Indicus|evm.model.CM009514.1.182 Q4R630 NDC80_MACFA 90.654 0.99689 1.00156 NDC80 - Kinetochore protein NDC80 homolog - Macaca fascicularis (Crab-eating macaque) - NDC80 gene Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules. Indicus|evm.model.CM009514.1.183 A8D8X1 RL10_SHEEP 77.083 0.482051 0.911215 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009514.1.184 A6NHR9 SMHD1_HUMAN 92.775 0.994494 0.996509 SMCHD1 - Structural maintenance of chromosomes flexible hinge domain-containing protein 1 - Homo sapiens (Human) - SMCHD1 gene Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:25294876, PubMed:24790221). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). Indicus|evm.model.CM009514.1.185 Q9BXX0 EMIL2_HUMAN 91.228 0.178759 0.903134 EMILIN2 - EMILIN-2 precursor - Homo sapiens (Human) - EMILIN2 gene May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. Indicus|evm.model.CM009514.1.187 Q92539 LPIN2_HUMAN 88.616 0.931651 1.06138 LPIN2 - Phosphatidate phosphatase LPIN2 - Homo sapiens (Human) - LPIN2 gene Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. Indicus|evm.model.CM009514.1.188 P52179 MYOM1_HUMAN 86.256 0.998192 0.98457 MYOM1 - Myomesin-1 - Homo sapiens (Human) - MYOM1 gene Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. Indicus|evm.model.CM009514.1.189 Q5E9E2 MYL9_BOVIN 100.000 0.655172 1.51744 MYL9 - Myosin regulatory light polypeptide 9 - Bos taurus (Bovine) - MYL9 gene Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). Indicus|evm.model.CM009514.1.190 Q15583 TGIF1_HUMAN 90.977 0.5902 1.1197 TGIF1 - Homeobox protein TGIF1 - Homo sapiens (Human) - TGIF1 gene Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. Indicus|evm.model.CM009514.1.191 O14490 DLGP1_HUMAN 96.353 0.997976 1.01126 DLGAP1 - Disks large-associated protein 1 - Homo sapiens (Human) - DLGAP1 gene Part of the postsynaptic scaffold in neuronal cells. Indicus|evm.model.CM009514.1.194 P50894 RS7_TAKRU 82.432 0.973333 0.386598 rps7 - 40S ribosomal protein S7 - Takifugu rubripes (Japanese pufferfish) - rps7 gene Indicus|evm.model.CM009514.1.195 P0CW23 AKAI1_HUMAN 66.667 0.223368 4.21739 AKAIN1 - A-kinase anchor protein inhibitor 1 - Homo sapiens (Human) - AKAIN1 gene Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177). Indicus|evm.model.CM009514.1.197 O43829 ZBT14_HUMAN 99.330 0.982418 1.01336 ZBTB14 - Zinc finger and BTB domain-containing protein 14 - Homo sapiens (Human) - ZBTB14 gene Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. Indicus|evm.model.CM009514.1.198 Q9Y2J2 E41L3_HUMAN 89.454 0.566239 0.861086 EPB41L3 - Band 4.1-like protein 3 - Homo sapiens (Human) - EPB41L3 gene Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. Indicus|evm.model.CM009514.1.199 A6NKL6 T200C_HUMAN 64.729 0.656338 0.571659 TMEM200C - Transmembrane protein 200C - Homo sapiens (Human) - TMEM200C gene Indicus|evm.model.CM009514.1.201 Q9P2N2 RHG28_HUMAN 81.028 0.973042 1.06859 ARHGAP28 - Rho GTPase-activating protein 28 - Homo sapiens (Human) - ARHGAP28 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009514.1.202 P25391 LAMA1_HUMAN 77.821 0.994069 0.986992 LAMA1 - Laminin subunit alpha-1 precursor - Homo sapiens (Human) - LAMA1 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Indicus|evm.model.CM009514.1.203 A6NM36 LRC30_HUMAN 82.450 0.993377 1.00332 LRRC30 - Leucine-rich repeat-containing protein 30 - Homo sapiens (Human) - LRRC30 gene cytoplasm, intracellular membrane-bounded organelle, protein serine/threonine phosphatase activity, signal transduction Indicus|evm.model.CM009514.1.204 P28827 PTPRM_HUMAN 97.314 0.998623 1 PTPRM - Receptor-type tyrosine-protein phosphatase mu precursor - Homo sapiens (Human) - PTPRM gene Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. Indicus|evm.model.CM009514.1.205 P35283 RAB12_MOUSE 94.318 0.0790068 9.11523 Rab12 - Ras-related protein Rab-12 - Mus musculus (Mouse) - Rab12 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy. Indicus|evm.model.CM009514.1.206 P04394 NDUV2_BOVIN 100.000 0.992 1.00402 NDUFV2 - NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor - Bos taurus (Bovine) - NDUFV2 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Indicus|evm.model.CM009514.1.207 Q6UB98 ANR12_HUMAN 86.786 0.999014 0.983511 ANKRD12 - Ankyrin repeat domain-containing protein 12 - Homo sapiens (Human) - ANKRD12 gene May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Indicus|evm.model.CM009514.1.208 Q98T89 TWSG1_CHICK 98.000 0.888393 1 TWSG1 - Twisted gastrulation protein homolog 1 precursor - Gallus gallus (Chicken) - TWSG1 gene May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). Indicus|evm.model.CM009514.1.209 Q15311 RBP1_HUMAN 90.382 0.996855 0.970992 RALBP1 - RalA-binding protein 1 - Homo sapiens (Human) - RALBP1 gene Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). Indicus|evm.model.CM009514.1.210 Q8TF05 PP4R1_HUMAN 84.171 0.987097 0.978947 PPP4R1 - Serine/threonine-protein phosphatase 4 regulatory subunit 1 - Homo sapiens (Human) - PPP4R1 gene Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Indicus|evm.model.CM009514.1.211 Q6GQP4 RAB31_RAT 96.175 0.664234 1.41237 Rab31 - Ras-related protein Rab-31 - Rattus norvegicus (Rat) - Rab31 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Indicus|evm.model.CM009514.1.212 P82460 THIO_PIG 60.577 0.158706 6.18095 TXN - Thioredoxin - Sus scrofa (Pig) - TXN gene Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). Indicus|evm.model.CM009514.1.213 Q0VCY1 VAPA_BOVIN 77.941 0.921769 1.18072 VAPA - Vesicle-associated membrane protein-associated protein A - Bos taurus (Bovine) - VAPA gene Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. Indicus|evm.model.CM009514.1.215 Q8J025 APCD1_HUMAN 87.898 0.930693 0.98249 APCDD1 - Protein APCDD1 precursor - Homo sapiens (Human) - APCDD1 gene Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis. Indicus|evm.model.CM009514.1.216 P81127 SNAG_BOVIN 100.000 0.787342 1.26603 NAPG - Gamma-soluble NSF attachment protein - Bos taurus (Bovine) - NAPG gene Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Indicus|evm.model.CM009514.1.217 Q9H5I5 PIEZ2_HUMAN 90.115 0.99927 0.995276 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Indicus|evm.model.CM009514.1.223 Q8CGK7 GNAL_MOUSE 88.976 0.994135 0.895013 Gnal - Guanine nucleotide-binding protein G(olf) subunit alpha - Mus musculus (Mouse) - Gnal gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters (By similarity). Indicus|evm.model.CM009514.1.224 D2I2M6 MPPE1_AILME 74.436 0.896163 1.1301 MPPE1 - Metallophosphoesterase 1 - Ailuropoda melanoleuca (Giant panda) - MPPE1 gene Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity). Indicus|evm.model.CM009514.1.225 O14732 IMPA2_HUMAN 80.208 0.586957 1.59722 IMPA2 - Inositol monophosphatase 2 - Homo sapiens (Human) - IMPA2 gene Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. Indicus|evm.model.CM009514.1.226 O60543 CIDEA_HUMAN 73.118 0.398268 1.05479 CIDEA - Cell death activator CIDE-A - Homo sapiens (Human) - CIDEA gene Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. Indicus|evm.model.CM009514.1.227 Q2HJ81 TBB6_BOVIN 100.000 0.93883 0.843049 TUBB6 - Tubulin beta-6 chain - Bos taurus (Bovine) - TUBB6 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.CM009514.1.228 Q2KJI7 AFG32_BOVIN 100.000 0.997519 1.00124 AFG3L2 - AFG3-like protein 2 precursor - Bos taurus (Bovine) - AFG3L2 gene ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity). Involved in the regulation of OMA1-dependent processing of OPA1 (By similarity). Indicus|evm.model.CM009514.1.229 Q96N28 PLD3A_HUMAN 89.535 0.695122 1.43023 PRELID3A - PRELI domain containing protein 3A - Homo sapiens (Human) - PRELID3A gene In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane. Indicus|evm.model.CM009514.1.230 Q4R707 SPIR1_MACFA 90.240 0.805249 1.23973 SPIRE1 - Protein spire homolog 1 - Macaca fascicularis (Crab-eating macaque) - SPIRE1 gene Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Indicus|evm.model.CM009514.1.231 Q8TAP6 CEP76_HUMAN 96.520 0.996979 1.00455 CEP76 - Centrosomal protein of 76 kDa - Homo sapiens (Human) - CEP76 gene Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. Indicus|evm.model.CM009514.1.232 Q2NL24 PSMG2_BOVIN 100.000 0.992453 1.00379 PSMG2 - Proteasome assembly chaperone 2 - Bos taurus (Bovine) - PSMG2 gene Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity). Indicus|evm.model.CM009514.1.233 P17706 PTN2_HUMAN 90.052 0.979434 0.937349 PTPN2 - Tyrosine-protein phosphatase non-receptor type 2 - Homo sapiens (Human) - PTPN2 gene Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA. Indicus|evm.model.CM009514.1.235 A7YY75 SEH1_BOVIN 100.000 0.843602 1.17222 SEH1L - Nucleoporin SEH1 - Bos taurus (Bovine) - SEH1L gene Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Indicus|evm.model.CM009514.1.236 Q9NZV8 KCND2_HUMAN 77.215 0.0304926 4.06032 KCND2 - Potassium voltage-gated channel subfamily D member 2 - Homo sapiens (Human) - KCND2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). Indicus|evm.model.CM009514.1.238 O15165 LRAD4_HUMAN 77.632 0.980519 1.00654 LDLRAD4 - Low-density lipoprotein receptor class A domain-containing protein 4 - Homo sapiens (Human) - LDLRAD4 gene Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Indicus|evm.model.CM009514.1.239 Q05B67 F210A_BOVIN 99.251 0.808511 1.20513 FAM210A - Protein FAM210A - Bos taurus (Bovine) - FAM210A gene May play a role in the structure and strength of both muscle and bone. Indicus|evm.model.CM009514.1.240 Q4R7K1 MCES_MACFA 86.402 0.995816 1.0042 RNMT - mRNA cap guanine-N7 methyltransferase - Macaca fascicularis (Crab-eating macaque) - RNMT gene Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC. Indicus|evm.model.CM009514.1.241 P56451 MC5R_BOVIN 100.000 0.993865 1.00308 MC5R - Melanocortin receptor 5 - Bos taurus (Bovine) - MC5R gene Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins (By similarity). Indicus|evm.model.CM009514.1.242 P34974 ACTHR_BOVIN 99.663 0.993289 1.00337 MC2R - Adrenocorticotropic hormone receptor - Bos taurus (Bovine) - MC2R gene Receptor for corticotropin (ACTH). This receptor is mediated by G proteins which activate adenylate cyclase (cAMP). Indicus|evm.model.CM009514.1.243 P15103 GLNA_BOVIN 95.710 0.994638 1 GLUL - Glutamine synthetase - Bos taurus (Bovine) - GLUL gene Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Indicus|evm.model.CM009514.1.244 Q9H5I5 PIEZ2_HUMAN 90.411 0.244068 0.107195 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Indicus|evm.model.CM009514.1.246 Q28614 UT2_RABIT 90.428 0.373233 2.67254 SLC14A2 - Urea transporter 2 - Oryctolagus cuniculus (Rabbit) - SLC14A2 gene Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Indicus|evm.model.CM009514.1.247 Q5QF96 UT1_BOVIN 100.000 0.870455 1.14583 SLC14A1 - Urea transporter 1 - Bos taurus (Bovine) - SLC14A1 gene Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means. Indicus|evm.model.CM009514.1.248 Q6ZMC9 SIG15_HUMAN 89.000 0.552778 1.09756 SIGLEC15 - Sialic acid-binding Ig-like lectin 15 precursor - Homo sapiens (Human) - SIGLEC15 gene Binds sialylated glycoproteins. Indicus|evm.model.CM009514.1.249 Q9HCE0 EPG5_HUMAN 90.500 0.999225 1 EPG5 - Ectopic P granules protein 5 homolog - Homo sapiens (Human) - EPG5 gene Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located (PubMed:29130391). Indicus|evm.model.CM009514.1.250 P62246 RS15A_RAT 79.070 0.976562 0.984615 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Indicus|evm.model.CM009514.1.251 Q9H939 PPIP2_HUMAN 87.463 0.99403 1.00299 PSTPIP2 - Proline-serine-threonine phosphatase-interacting protein 2 - Homo sapiens (Human) - PSTPIP2 gene Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity). Indicus|evm.model.CM009514.1.252 P19483 ATPA_BOVIN 99.819 0.99639 1.00181 ATP5F1A - ATP synthase subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1A gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). Indicus|evm.model.CM009514.1.253 Q2TBK4 HAUS1_BOVIN 99.640 0.992832 1.0036 HAUS1 - HAUS augmin-like complex subunit 1 - Bos taurus (Bovine) - HAUS1 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Indicus|evm.model.CM009514.1.254 Q5R4B7 CR025_PONAB 98.810 0.26183 1.15273 Uncharacterized protein C18orf25 homolog - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009514.1.255 Q6ZSG1 RN165_HUMAN 97.859 0.976048 0.965318 RNF165 - E3 ubiquitin-protein ligase RNF165 - Homo sapiens (Human) - RNF165 gene E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Indicus|evm.model.CM009514.1.256 Q8IVV2 LOXH1_HUMAN 86.930 0.583593 1.08515 LOXHD1 - Lipoxygenase homology domain-containing protein 1 - Homo sapiens (Human) - LOXHD1 gene Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity). Indicus|evm.model.CM009514.1.257 P61646 SIA8E_PANTR 90.534 0.995157 1.0984 ST8SIA5 - Alpha-2,8-sialyltransferase 8E - Pan troglodytes (Chimpanzee) - ST8SIA5 gene Involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, GP1c and GT3 from GD1a, GT1b, GM1b and GD3 respectively. Indicus|evm.model.CM009514.1.258 O75928 PIAS2_HUMAN 97.390 0.948837 1.03865 PIAS2 - E3 SUMO-protein ligase PIAS2 - Homo sapiens (Human) - PIAS2 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'. Indicus|evm.model.CM009514.1.259 P62268 RS23_RAT 96.324 0.77907 1.2028 Rps23 - 40S ribosomal protein S23 - Rattus norvegicus (Rat) - Rps23 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Indicus|evm.model.CM009514.1.260 Q14241 ELOA1_HUMAN 55.821 0.996909 0.810777 ELOA - Elongin-A - Homo sapiens (Human) - ELOA gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Indicus|evm.model.CM009514.1.261 Q3ZCH9 HDHD2_BOVIN 94.853 0.209302 2.49035 HDHD2 - Haloacid dehalogenase-like hydrolase domain-containing protein 2 - Bos taurus (Bovine) - HDHD2 gene enzyme binding, phosphatase activity, dephosphorylation Indicus|evm.model.CM009514.1.262 Q3ZCH9 HDHD2_BOVIN 100.000 0.873333 0.579151 HDHD2 - Haloacid dehalogenase-like hydrolase domain-containing protein 2 - Bos taurus (Bovine) - HDHD2 gene enzyme binding, phosphatase activity, dephosphorylation Indicus|evm.model.CM009514.1.263 A7M7C7 SKOR2_MOUSE 99.225 0.434856 0.58631 Skor2 - SKI family transcriptional corepressor 2 - Mus musculus (Mouse) - Skor2 gene Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. Indicus|evm.model.CM009514.1.265 Q62432 SMAD2_MOUSE 93.576 0.995434 0.937901 Smad2 - Mothers against decapentaplegic homolog 2 - Mus musculus (Mouse) - Smad2 gene Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). Indicus|evm.model.CM009514.1.266 Q8VCZ7 ZBT7C_MOUSE 100.000 0.0693241 0.932149 Zbtb7c - Zinc finger and BTB domain-containing protein 7C - Mus musculus (Mouse) - Zbtb7c gene May be a tumor suppressor gene. Indicus|evm.model.CM009514.1.270 Q78EG7 TP4A1_RAT 71.795 0.957983 0.687861 Ptp4a1 - Protein tyrosine phosphatase type IVA 1 precursor - Rattus norvegicus (Rat) - Ptp4a1 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). Indicus|evm.model.CM009514.1.271 O43310 CTIF_HUMAN 92.333 0.996672 1.00502 CTIF - CBP80/20-dependent translation initiation factor - Homo sapiens (Human) - CTIF gene Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). Indicus|evm.model.CM009514.1.273 O15105 SMAD7_HUMAN 92.254 0.995025 0.943662 SMAD7 - Mothers against decapentaplegic homolog 7 - Homo sapiens (Human) - SMAD7 gene Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Indicus|evm.model.CM009514.1.275 Q7RTS9 DYM_HUMAN 97.309 0.997015 1.00149 DYM - Dymeclin - Homo sapiens (Human) - DYM gene Necessary for correct organization of Golgi apparatus. Involved in bone development. Indicus|evm.model.CM009514.1.276 Q3ZC78 CR032_BOVIN 86.567 0.636364 1.30263 UPF0729 protein C18orf32 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009514.1.277 P24049 RL17_RAT 100.000 0.989189 1.00543 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009514.1.279 Q9Y5X9 LIPE_HUMAN 88.776 0.928571 0.42 LIPG - Endothelial lipase precursor - Homo sapiens (Human) - LIPG gene Exerts both phospholipase and triglyceride lipase activities (PubMed:12032167, PubMed:10318835, PubMed:10192396). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (PubMed:12032167). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (PubMed:12032167, PubMed:10192396). Indicus|evm.model.CM009514.1.280 Q9Y5X9 LIPE_HUMAN 79.225 0.933775 0.604 LIPG - Endothelial lipase precursor - Homo sapiens (Human) - LIPG gene Exerts both phospholipase and triglyceride lipase activities (PubMed:12032167, PubMed:10318835, PubMed:10192396). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (PubMed:12032167). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (PubMed:12032167, PubMed:10192396). Indicus|evm.model.CM009514.1.281 Q3T0R7 THIM_BOVIN 100.000 0.994975 1.00252 ACAA2 - 3-ketoacyl-CoA thiolase, mitochondrial - Bos taurus (Bovine) - ACAA2 gene In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activity on various fatty acyl-CoAs (By similarity). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (By similarity). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (By similarity). Indicus|evm.model.CM009514.1.282 Q9ULV0 MYO5B_HUMAN 90.000 0.990148 0.988636 MYO5B - Unconventional myosin-Vb - Homo sapiens (Human) - MYO5B gene May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Indicus|evm.model.CM009514.1.283 P18760 COF1_MOUSE 67.442 0.43617 0.566265 Cfl1 - Cofilin-1 - Mus musculus (Mouse) - Cfl1 gene Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11809832). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:25208553). Required for the centralization of the mitotic spindle and symmetric division of zygotes (PubMed:25208553). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (PubMed:15649475). Indicus|evm.model.CM009514.1.284 Q9UIS9 MBD1_HUMAN 86.341 0.500423 1.95537 MBD1 - Methyl-CpG-binding domain protein 1 - Homo sapiens (Human) - MBD1 gene Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. Indicus|evm.model.CM009514.1.285 Q5EA28 CXXC1_BOVIN 100.000 0.996965 1.00152 CXXC1 - CXXC-type zinc finger protein 1 - Bos taurus (Bovine) - CXXC1 gene Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. Indicus|evm.model.CM009514.1.286 Q0V7M7 SKA1_BOVIN 99.587 0.649596 1.46063 SKA1 - Spindle and kinetochore-associated protein 1 - Bos taurus (Bovine) - SKA1 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. In the complex, it mediates the interaction with microtubules. Indicus|evm.model.CM009514.1.287 Q63454 MK04_RAT 92.701 0.413011 2.41241 Mapk4 - Mitogen-activated protein kinase 4 - Rattus norvegicus (Rat) - Mapk4 gene Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). Indicus|evm.model.CM009514.1.288 Q58DE2 MSTRO_BOVIN 97.899 0.800676 1.12548 MRO - Protein maestro - Bos taurus (Bovine) - MRO gene Indicus|evm.model.CM009514.1.290 P23368 MAOM_HUMAN 91.781 0.996581 1.00171 ME2 - NAD-dependent malic enzyme, mitochondrial precursor - Homo sapiens (Human) - ME2 gene intracellular membrane-bounded organelle, mitochondrial matrix, mitochondrion, electron transfer activity, malate dehydrogenase (decarboxylating) (NAD+) activity, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, malate metabolic process, pyruvate metabolic process, regulation of NADP metabolic process Indicus|evm.model.CM009514.1.291 Q29RY4 RNZ1_BOVIN 100.000 0.994505 1.00275 ELAC1 - Zinc phosphodiesterase ELAC protein 1 - Bos taurus (Bovine) - ELAC1 gene Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity). Indicus|evm.model.CM009514.1.292 Q1HE26 SMAD4_BOVIN 99.277 0.99639 1.00181 SMAD4 - Mothers against decapentaplegic homolog 4 - Bos taurus (Bovine) - SMAD4 gene Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity). Indicus|evm.model.CM009514.1.294 Q05A36 MEX3C_MOUSE 97.260 0.788253 0.992331 Mex3c - RNA-binding E3 ubiquitin-protein ligase MEX3C - Mus musculus (Mouse) - Mex3c gene RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. Indicus|evm.model.CM009514.1.295 Q9DCR2 AP3S1_MOUSE 89.011 0.947368 0.492228 Ap3s1 - AP-3 complex subunit sigma-1 - Mus musculus (Mouse) - Ap3s1 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Indicus|evm.model.CM009514.1.296 Q5R893 H2B1_PONAB 95.575 0.973913 0.912698 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009514.1.298 P43146 DCC_HUMAN 92.135 0.871287 0.0697996 DCC - Netrin receptor DCC precursor - Homo sapiens (Human) - DCC gene Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Indicus|evm.model.CM009514.1.299 P43146 DCC_HUMAN 96.392 0.810924 0.164478 DCC - Netrin receptor DCC precursor - Homo sapiens (Human) - DCC gene Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Indicus|evm.model.CM009514.1.300 P43146 DCC_HUMAN 96.809 0.522472 0.123013 DCC - Netrin receptor DCC precursor - Homo sapiens (Human) - DCC gene Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Indicus|evm.model.CM009514.1.301 P43146 DCC_HUMAN 93.269 0.585227 0.121631 DCC - Netrin receptor DCC precursor - Homo sapiens (Human) - DCC gene Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Indicus|evm.model.CM009514.1.302 P43146 DCC_HUMAN 98.214 0.606557 0.126469 DCC - Netrin receptor DCC precursor - Homo sapiens (Human) - DCC gene Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Indicus|evm.model.CM009514.1.303 P43146 DCC_HUMAN 93.951 0.997347 0.521078 DCC - Netrin receptor DCC precursor - Homo sapiens (Human) - DCC gene Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Indicus|evm.model.CM009514.1.304 Q9UBB5 MBD2_HUMAN 96.482 0.99 0.486618 MBD2 - Methyl-CpG-binding domain protein 2 - Homo sapiens (Human) - MBD2 gene Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. Indicus|evm.model.CM009514.1.305 Q9UNA4 POLI_HUMAN 83.448 0.965241 1.01081 POLI - DNA polymerase iota - Homo sapiens (Human) - POLI gene Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunogobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940). Indicus|evm.model.CM009514.1.306 P59095 STAR6_HUMAN 75.706 0.752137 1.06364 STARD6 - StAR-related lipid transfer protein 6 - Homo sapiens (Human) - STARD6 gene May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity). Indicus|evm.model.CM009514.1.307 Q4R815 LAS2_MACFA 86.620 0.266038 1.64596 LAS2 - Lung adenoma susceptibility protein 2 homolog precursor - Macaca fascicularis (Crab-eating macaque) - LAS2 gene Might play a role in cell proliferation. Indicus|evm.model.CM009514.1.311 Q0II50 USB1_BOVIN 94.253 0.380531 0.85283 USB1 - U6 snRNA phosphodiesterase - Bos taurus (Bovine) - USB1 gene Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Indicus|evm.model.CM009514.1.313 Q8HZJ5 RB27B_BOVIN 100.000 0.875 1.13761 RAB27B - Ras-related protein Rab-27B - Bos taurus (Bovine) - RAB27B gene Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes (PubMed:14625374). Indicus|evm.model.CM009514.1.314 Q9H2F9 CCD68_HUMAN 81.646 0.872576 1.07761 CCDC68 - Coiled-coil domain-containing protein 68 - Homo sapiens (Human) - CCDC68 gene Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Indicus|evm.model.CM009514.1.315 P15881 ITF2_CANLF 97.682 0.96131 1.04673 TCF4 - Transcription factor 4 - Canis lupus familiaris (Dog) - TCF4 gene Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). Binds to the thyroglobulin promoter. Indicus|evm.model.CM009514.1.318 O43396 TXNL1_HUMAN 99.291 0.936667 1.03806 TXNL1 - Thioredoxin-like protein 1 - Homo sapiens (Human) - TXNL1 gene Active thioredoxin with a redox potential of about -250 mV. Indicus|evm.model.CM009514.1.319 Q9Y4E6 WDR7_HUMAN 96.259 0.979505 0.949664 WDR7 - WD repeat-containing protein 7 - Homo sapiens (Human) - WDR7 gene Indicus|evm.model.CM009514.1.321 O43173 SIA8C_HUMAN 93.947 0.994737 1 ST8SIA3 - Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase - Homo sapiens (Human) - ST8SIA3 gene Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid. Indicus|evm.model.CM009514.1.322 Q8JZM4 DNER_MOUSE 97.561 0.778846 0.141113 Dner - Delta and Notch-like epidermal growth factor-related receptor precursor - Mus musculus (Mouse) - Dner gene Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling. Indicus|evm.model.CM009514.1.323 O95948 ONEC2_HUMAN 97.315 0.993311 0.593254 ONECUT2 - One cut domain family member 2 - Homo sapiens (Human) - ONECUT2 gene Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B. Indicus|evm.model.CM009514.1.324 P22600 HEMH_BOVIN 99.760 0.995204 1.0024 FECH - Ferrochelatase, mitochondrial precursor - Bos taurus (Bovine) - FECH gene Catalyzes the ferrous insertion into protoporphyrin IX. Indicus|evm.model.CM009514.1.325 Q2KJG3 SYNC_BOVIN 99.821 0.996429 1.00179 NARS - Asparagine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - NARS gene Indicus|evm.model.CM009514.1.326 O43520 AT8B1_HUMAN 91.607 0.998403 1.0008 ATP8B1 - Phospholipid-transporting ATPase IC - Homo sapiens (Human) - ATP8B1 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:17948906). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (PubMed:20512993). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:25239307, PubMed:27301931). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (PubMed:20510206). Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity). Indicus|evm.model.CM009514.1.328 Q5RBF2 NED4L_PONAB 98.292 0.848595 1.15016 NEDD4L - E3 ubiquitin-protein ligase NEDD4-like - Pongo abelii (Sumatran orangutan) - NEDD4L gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes (By similarity). Involved in the regulation of TOR signaling (By similarity). Indicus|evm.model.CM009514.1.329 Q86TB3 ALPK2_HUMAN 59.468 0.978674 0.994009 ALPK2 - Alpha-protein kinase 2 - Homo sapiens (Human) - ALPK2 gene Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). Indicus|evm.model.CM009514.1.330 Q9UDY8 MALT1_HUMAN 89.659 0.964747 1.03277 MALT1 - Mucosa-associated lymphoid tissue lymphoma translocation protein 1 - Homo sapiens (Human) - MALT1 gene Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475). Indicus|evm.model.CM009514.1.333 Q5RC30 SC11C_PONAB 98.438 0.989637 1.00521 SEC11C - Signal peptidase complex catalytic subunit SEC11C - Pongo abelii (Sumatran orangutan) - SEC11C gene Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Indicus|evm.model.CM009514.1.334 Q863C3 GRP_BOVIN 100.000 0.985185 1.00746 GRP - Gastrin-releasing peptide precursor - Bos taurus (Bovine) - GRP gene Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity). Indicus|evm.model.CM009514.1.335 Q9Y2V3 RX_HUMAN 100.000 0.175732 0.690751 RAX - Retinal homeobox protein Rx - Homo sapiens (Human) - RAX gene Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter. Indicus|evm.model.CM009514.1.336 Q7Z7G2 CPLX4_HUMAN 94.375 0.987578 1.00625 CPLX4 - Complexin-4 precursor - Homo sapiens (Human) - CPLX4 gene Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). Indicus|evm.model.CM009514.1.337 P49257 LMAN1_HUMAN 92.483 0.908714 0.945098 LMAN1 - Protein ERGIC-53 precursor - Homo sapiens (Human) - LMAN1 gene Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Indicus|evm.model.CM009514.1.338 Q6UXH8 CCBE1_HUMAN 86.029 0.99511 1.00739 CCBE1 - Collagen and calcium-binding EGF domain-containing protein 1 precursor - Homo sapiens (Human) - CCBE1 gene Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Indicus|evm.model.CM009514.1.341 Q13794 APR_HUMAN 69.565 0.392857 2.07407 PMAIP1 - Phorbol-12-myristate-13-acetate-induced protein 1 - Homo sapiens (Human) - PMAIP1 gene Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Indicus|evm.model.CM009514.1.343 Q920A7 AFG31_MOUSE 72.654 0.645594 0.661597 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Indicus|evm.model.CM009514.1.344 Q9GLJ8 MC4R_BOVIN 99.699 0.993994 1.00301 MC4R - Melanocortin receptor 4 - Bos taurus (Bovine) - MC4R gene Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). Indicus|evm.model.CM009514.1.346 Q5IS68 DCE1_PANTR 65.226 0.979705 0.912458 GAD1 - Glutamate decarboxylase 1 - Pan troglodytes (Chimpanzee) - GAD1 gene Catalyzes the production of GABA. Indicus|evm.model.CM009514.1.347 Q71U00 SKP1_XENLA 100.000 0.602151 0.570552 skp1 - S-phase kinase-associated protein 1 - Xenopus laevis (African clawed frog) - skp1 gene Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). Indicus|evm.model.CM009514.1.348 O35737 HNRH1_MOUSE 79.651 0.890625 0.427617 Hnrnph1 - Heterogeneous nuclear ribonucleoprotein H - Mus musculus (Mouse) - Hnrnph1 gene This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity). Indicus|evm.model.CM009514.1.351 P62828 RAN_RAT 90.506 0.987179 0.722222 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Indicus|evm.model.CM009514.1.353 Q9HBT6 CAD20_HUMAN 96.380 0.997506 1.00125 CDH20 - Cadherin-20 precursor - Homo sapiens (Human) - CDH20 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Indicus|evm.model.CM009514.1.354 Q58EC8 RN152_DANRE 76.190 0.390476 0.530303 rnf152 - E3 ubiquitin-protein ligase rnf152 - Danio rerio (Zebrafish) - rnf152 gene E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Indicus|evm.model.CM009514.1.356 O95427 PIGN_HUMAN 80.517 0.995708 1.00107 PIGN - GPI ethanolamine phosphate transferase 1 - Homo sapiens (Human) - PIGN gene Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation. Indicus|evm.model.CM009514.1.357 Q9P260 RELCH_HUMAN 93.421 0.998351 0.997533 RELCH - RAB11-binding protein RELCH - Homo sapiens (Human) - RELCH gene Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). Indicus|evm.model.CM009514.1.358 Q9Y6Q6 TNR11_HUMAN 56.936 0.752137 0.949675 TNFRSF11A - Tumor necrosis factor receptor superfamily member 11A precursor - Homo sapiens (Human) - TNFRSF11A gene Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Indicus|evm.model.CM009514.1.359 Q9C0B9 ZCHC2_HUMAN 84.771 0.983666 0.467742 ZCCHC2 - Zinc finger CCHC domain-containing protein 2 - Homo sapiens (Human) - ZCCHC2 gene cytoplasm Indicus|evm.model.CM009514.1.362 Q9WTR8 PHLP1_RAT 72.727 0.282869 0.147995 Phlpp1 - PH domain leucine-rich repeat protein phosphatase 1 - Rattus norvegicus (Rat) - Phlpp1 gene Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:20819118). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons while isoform 1 may promote Akt and PKC activation and inhibit ERK signaling (PubMed:20819118). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (By similarity). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (By similarity). Inhibits cancer cell proliferation and may act as a tumor suppressor (By similarity). Dephosphorylates RAF1 inhibiting its kinase activity (By similarity). May act as a negative regulator of K-Ras signaling in membrane rafts (PubMed:12594205). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). Indicus|evm.model.CM009514.1.364 O60346 PHLP1_HUMAN 91.913 0.877 0.582411 PHLPP1 - PH domain leucine-rich repeat-containing protein phosphatase 1 - Homo sapiens (Human) - PHLPP1 gene Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). Indicus|evm.model.CM009514.1.365 B2KI30 SPB10_RHIFE 55.797 0.853503 0.395466 SERPINB10 - Serpin B10 - Rhinolophus ferrumequinum (Greater horseshoe bat) - SERPINB10 gene Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). Indicus|evm.model.CM009514.1.367 O02718 BCL2_BOVIN 93.013 0.991304 1.00437 BCL2 - Apoptosis regulator Bcl-2 - Bos taurus (Bovine) - BCL2 gene Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). Indicus|evm.model.CM009514.1.368 Q2KIJ5 KDSR_BOVIN 99.324 0.904908 0.984894 KDSR - 3-ketodihydrosphingosine reductase precursor - Bos taurus (Bovine) - KDSR gene Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). Indicus|evm.model.CM009514.1.369 Q0VD48 VPS4B_BOVIN 100.000 0.995506 1.00225 VPS4B - Vacuolar protein sorting-associated protein 4B - Bos taurus (Bovine) - VPS4B gene Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Involved in cytokinesis. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Indicus|evm.model.CM009514.1.370 P36952 SPB5_HUMAN 91.200 0.994681 1.00267 SERPINB5 - Serpin B5 - Homo sapiens (Human) - SERPINB5 gene Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Indicus|evm.model.CM009514.1.371 Q96P63 SPB12_HUMAN 76.235 0.995305 1.05185 SERPINB12 - Serpin B12 - Homo sapiens (Human) - SERPINB12 gene Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. Indicus|evm.model.CM009514.1.372 Q9UIV8 SPB13_HUMAN 67.008 0.994505 0.930946 SERPINB13 - Serpin B13 - Homo sapiens (Human) - SERPINB13 gene May play a role in the proliferation or differentiation of keratinocytes. Indicus|evm.model.CM009514.1.373 A9RA96 SPB10_PAPAN 55.556 0.705263 0.478589 SERPINB10 - Serpin B10 - Papio anubis (Olive baboon) - SERPINB10 gene Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). Indicus|evm.model.CM009514.1.374 P48594 SPB4_HUMAN 65.473 0.994898 1.00513 SERPINB4 - Serpin B4 - Homo sapiens (Human) - SERPINB4 gene May act as a protease inhibitor to modulate the host immune response against tumor cells. Indicus|evm.model.CM009514.1.375 P48594 SPB4_HUMAN 66.102 0.875 0.861538 SERPINB4 - Serpin B4 - Homo sapiens (Human) - SERPINB4 gene May act as a protease inhibitor to modulate the host immune response against tumor cells. Indicus|evm.model.CM009514.1.376 P48594 SPB4_HUMAN 62.404 0.994521 0.935897 SERPINB4 - Serpin B4 - Homo sapiens (Human) - SERPINB4 gene May act as a protease inhibitor to modulate the host immune response against tumor cells. Indicus|evm.model.CM009514.1.377 P48594 SPB4_HUMAN 68.106 0.990066 0.774359 SERPINB4 - Serpin B4 - Homo sapiens (Human) - SERPINB4 gene May act as a protease inhibitor to modulate the host immune response against tumor cells. Indicus|evm.model.CM009514.1.378 P48594 SPB4_HUMAN 64.450 0.994872 1 SERPINB4 - Serpin B4 - Homo sapiens (Human) - SERPINB4 gene May act as a protease inhibitor to modulate the host immune response against tumor cells. Indicus|evm.model.CM009514.1.379 Q96P15 SPB11_HUMAN 68.622 0.994269 0.890306 SERPINB11 - Serpin B11 - Homo sapiens (Human) - SERPINB11 gene Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change. Indicus|evm.model.CM009514.1.380 O75635 SPB7_HUMAN 79.528 0.994764 1.00526 SERPINB7 - Serpin B7 - Homo sapiens (Human) - SERPINB7 gene Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. Indicus|evm.model.CM009514.1.382 P05120 PAI2_HUMAN 76.923 0.995204 1.00482 SERPINB2 - Plasminogen activator inhibitor 2 precursor - Homo sapiens (Human) - SERPINB2 gene Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Indicus|evm.model.CM009514.1.383 A5PJK0 SPB10_BOVIN 99.496 0.994975 1.00252 SERPINB10 - Serpin B10 - Bos taurus (Bovine) - SERPINB10 gene Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). Indicus|evm.model.CM009515.1.1 Q13136 LIPA1_HUMAN 75.000 0.197133 0.232113 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009515.1.2 Q5E9I1 CCNG1_BOVIN 99.371 0.9875 0.542373 CCNG1 - Cyclin-G1 - Bos taurus (Bovine) - CCNG1 gene May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). Indicus|evm.model.CM009515.1.3 Q01113 IL9R_HUMAN 64.691 0.684303 1.08829 IL9R - Interleukin-9 receptor precursor - Homo sapiens (Human) - IL9R gene This is a receptor for interleukin-9. Indicus|evm.model.CM009515.1.4 Q9CQZ7 RPC10_MOUSE 99.074 0.981651 1.00926 Polr3k - DNA-directed RNA polymerase III subunit RPC10 - Mus musculus (Mouse) - Polr3k gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Indicus|evm.model.CM009515.1.5 Q3ZBQ4 SNR25_BOVIN 100.000 0.61 1.62602 SNRNP25 - U11/U12 small nuclear ribonucleoprotein 25 kDa protein - Bos taurus (Bovine) - SNRNP25 gene U12-type spliceosomal complex Indicus|evm.model.CM009515.1.6 A7YWH9 RHDF1_BOVIN 100.000 0.997666 1.00117 RHBDF1 - Inactive rhomboid protein 1 - Bos taurus (Bovine) - RHBDF1 gene Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Indicus|evm.model.CM009515.1.8 P29372 3MG_HUMAN 75.088 0.72973 1.24161 MPG - DNA-3-methyladenine glycosylase precursor - Homo sapiens (Human) - MPG gene Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. Indicus|evm.model.CM009515.1.9 Q8VIJ8 NPRL3_MOUSE 93.497 0.996491 1.00176 Nprl3 - GATOR complex protein NPRL3 - Mus musculus (Mouse) - Nprl3 gene As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. Indicus|evm.model.CM009515.1.10 P13786 HBAZ_CAPHI 95.070 0.986014 1.00704 HBZ1 - Hemoglobin subunit zeta - Capra hircus (Goat) - HBZ1 gene The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin. Indicus|evm.model.CM009515.1.11 P13786 HBAZ_CAPHI 95.775 0.792135 1.25352 HBZ1 - Hemoglobin subunit zeta - Capra hircus (Goat) - HBZ1 gene The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin. Indicus|evm.model.CM009515.1.12 A1A4Q3 HBM_BOVIN 100.000 0.985915 1.00709 HBM - Hemoglobin subunit mu - Bos taurus (Bovine) - HBM gene haptoglobin-hemoglobin complex, hemoglobin complex, heme binding, organic acid binding, oxygen binding, oxygen carrier activity, hydrogen peroxide catabolic process Indicus|evm.model.CM009515.1.13 P01966 HBA_BOVIN 100.000 0.986014 1.00704 HBA - Hemoglobin subunit alpha - Bos taurus (Bovine) - HBA gene Involved in oxygen transport from the lung to the various peripheral tissues. Indicus|evm.model.CM009515.1.14 P01966 HBA_BOVIN 99.296 0.986014 1.00704 HBA - Hemoglobin subunit alpha - Bos taurus (Bovine) - HBA gene Involved in oxygen transport from the lung to the various peripheral tissues. Indicus|evm.model.CM009515.1.15 P06890 HBAT_PONPY 74.638 0.958042 1.00704 HBQ1 - Hemoglobin subunit theta-1 - Pongo pygmaeus (Bornean orangutan) - HBQ1 gene Indicus|evm.model.CM009515.1.16 P62305 RUXE_MOUSE 89.130 0.978495 1.01087 Snrpe - Small nuclear ribonucleoprotein E - Mus musculus (Mouse) - Snrpe gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. Indicus|evm.model.CM009515.1.17 Q9NQ29 LUC7L_HUMAN 97.844 0.994624 1.0027 LUC7L - Putative RNA-binding protein Luc7-like 1 - Homo sapiens (Human) - LUC7L gene May bind to RNA via its Arg/Ser-rich domain. Indicus|evm.model.CM009515.1.18 Q2HJE5 F234A_BOVIN 99.275 0.874603 1.1413 FAM234A - Protein FAM234A - Bos taurus (Bovine) - FAM234A gene cell surface Indicus|evm.model.CM009515.1.19 O94810 RGS11_HUMAN 79.601 0.957082 0.997859 RGS11 - Regulator of G-protein signaling 11 - Homo sapiens (Human) - RGS11 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Indicus|evm.model.CM009515.1.20 Q0II80 GDIR3_BOVIN 99.502 0.77821 1.14222 ARHGDIG - Rho GDP-dissociation inhibitor 3 - Bos taurus (Bovine) - ARHGDIG gene Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP (By similarity). Indicus|evm.model.CM009515.1.21 Q5RCH2 PDIA2_PONAB 84.017 0.847706 1.0381 PDIA2 - Protein disulfide-isomerase A2 precursor - Pongo abelii (Sumatran orangutan) - PDIA2 gene Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity). Indicus|evm.model.CM009515.1.22 O35625 AXIN1_MOUSE 87.197 0.997696 1.00579 Axin1 - Axin-1 - Mus musculus (Mouse) - Axin1 gene Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Indicus|evm.model.CM009515.1.23 Q2HJJ1 RM28_BOVIN 99.609 0.923913 1.07812 MRPL28 - 39S ribosomal protein L28, mitochondrial precursor - Bos taurus (Bovine) - MRPL28 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, structural constituent of ribosome Indicus|evm.model.CM009515.1.24 Q9HCN3 PGAP6_HUMAN 74.176 0.889163 1.05318 PGAP6 - Post-GPI attachment to proteins factor 6 precursor - Homo sapiens (Human) - PGAP6 gene Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). Indicus|evm.model.CM009515.1.25 O00746 NDKM_HUMAN 83.422 0.989362 1.00535 NME4 - Nucleoside diphosphate kinase, mitochondrial precursor - Homo sapiens (Human) - NME4 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663). Indicus|evm.model.CM009515.1.26 Q5RBV3 DECR2_PONAB 88.356 0.993151 1 DECR2 - Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] - Pongo abelii (Sumatran orangutan) - DECR2 gene Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. Indicus|evm.model.CM009515.1.27 O75154 RFIP3_HUMAN 68.843 0.994932 0.783069 RAB11FIP3 - Rab11 family-interacting protein 3 - Homo sapiens (Human) - RAB11FIP3 gene Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Indicus|evm.model.CM009515.1.28 O75808 CAN15_HUMAN 84.574 0.938596 1.04972 CAPN15 - Calpain-15 - Homo sapiens (Human) - CAPN15 gene cytoplasm, calcium-dependent cysteine-type endopeptidase activity, proteolysis Indicus|evm.model.CM009515.1.29 P0CG21 NHLC4_HUMAN 76.230 0.14491 6.78862 NHLRC4 - NHL-repeat-containing protein 4 - Homo sapiens (Human) - NHLRC4 gene ubiquitin protein ligase activity, protein K48-linked ubiquitination Indicus|evm.model.CM009515.1.30 Q9BRB3 PIGQ_HUMAN 85.686 0.851171 0.786842 PIGQ - Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q - Homo sapiens (Human) - PIGQ gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Indicus|evm.model.CM009515.1.31 Q96S21 RB40C_HUMAN 82.263 0.993902 1.16726 RAB40C - Ras-related protein Rab-40C - Homo sapiens (Human) - RAB40C gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009515.1.32 Q96NZ8 WFKN1_HUMAN 86.570 0.99637 1.00547 WFIKKN1 - WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor - Homo sapiens (Human) - WFIKKN1 gene Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). Indicus|evm.model.CM009515.1.33 Q32KX8 MTL26_BOVIN 100.000 0.990244 1.0049 METTL26 - Methyltransferase-like 26 - Bos taurus (Bovine) - METTL26 gene Indicus|evm.model.CM009515.1.34 Q5E9M9 MIRO2_BOVIN 100.000 0.994898 0.951456 RHOT2 - Mitochondrial Rho GTPase 2 - Bos taurus (Bovine) - RHOT2 gene Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). Indicus|evm.model.CM009515.1.35 O88779 RHBL1_RAT 99.390 0.480826 2.06707 Rhbdl1 - Rhomboid-related protein 1 - Rattus norvegicus (Rat) - Rhbdl1 gene May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Indicus|evm.model.CM009515.1.37 Q9UNE7 CHIP_HUMAN 98.020 0.993421 1.0033 STUB1 - E3 ubiquitin-protein ligase CHIP - Homo sapiens (Human) - STUB1 gene E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Likely mediates polyubiquitination and downregulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609). Indicus|evm.model.CM009515.1.38 Q96S16 JMJD8_HUMAN 88.618 0.839041 1.10606 JMJD8 - JmjC domain-containing protein 8 precursor - Homo sapiens (Human) - JMJD8 gene Functions as a positive regulator of TNF-induced NF-kappa-B signaling (PubMed:27671354). Regulates angiogenesis and cellular metabolism through interaction with PKM (PubMed:27199445). Indicus|evm.model.CM009515.1.39 Q96S15 WDR24_HUMAN 95.949 0.997472 1.00127 WDR24 - GATOR complex protein WDR24 - Homo sapiens (Human) - WDR24 gene As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823). Indicus|evm.model.CM009515.1.40 Q8N461 FXL16_HUMAN 94.410 0.995859 1.00835 FBXL16 - F-box/LRR-repeat protein 16 - Homo sapiens (Human) - FBXL16 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009515.1.41 Q0II70 MCRI2_BOVIN 98.039 0.469767 1.3871 MCRIP2 - MAPK regulated corepressor interacting protein 2 - Bos taurus (Bovine) - MCRIP2 gene cytoplasm, cytoplasmic stress granule, nucleus Indicus|evm.model.CM009515.1.42 Q96KV7 WDR90_HUMAN 67.493 0.94856 1.11213 WDR90 - WD repeat-containing protein 90 - Homo sapiens (Human) - WDR90 gene Required for efficient primary cilium formation. Indicus|evm.model.CM009515.1.43 Q9UJH8 METRN_HUMAN 80.952 0.931507 0.996587 METRN - Meteorin precursor - Homo sapiens (Human) - METRN gene Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity). Indicus|evm.model.CM009515.1.44 Q9BQD7 ANKMT_HUMAN 84.979 0.982379 0.965957 ANTKMT - Adenine nucleotide translocase lysine N-methyltransferase - Homo sapiens (Human) - ANTKMT gene Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526). Indicus|evm.model.CM009515.1.45 A2IDD5 CCD78_HUMAN 57.065 0.82448 0.988584 CCDC78 - Coiled-coil domain-containing protein 78 - Homo sapiens (Human) - CCDC78 gene Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome. Indicus|evm.model.CM009515.1.46 Q0VBY3 HAGHL_BOVIN 95.745 0.492958 1.4715 HAGHL - Hydroxyacylglutathione hydrolase-like protein - Bos taurus (Bovine) - HAGHL gene Hydrolase acting on ester bonds. Indicus|evm.model.CM009515.1.47 A4FV58 CIAO3_BOVIN 99.790 0.995807 1.0021 CIAO3 - Cytosolic iron-sulfur assembly component 3 - Bos taurus (Bovine) - CIAO3 gene Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity). Indicus|evm.model.CM009515.1.48 Q13421 MSLN_HUMAN 61.628 0.829208 0.64127 MSLN - Mesothelin precursor - Homo sapiens (Human) - MSLN gene Membrane-anchored forms may play a role in cellular adhesion. Indicus|evm.model.CM009515.1.49 Q96KJ4 MSLNL_HUMAN 67.619 0.733572 1.19231 MSLNL - Mesothelin-like protein precursor - Homo sapiens (Human) - MSLNL gene May play a role in cellular adhesion. Indicus|evm.model.CM009515.1.50 Q17QT4 RUSD1_BOVIN 100.000 0.993528 1.00325 RPUSD1 - RNA pseudouridylate synthase domain-containing protein 1 - Bos taurus (Bovine) - RPUSD1 gene pseudouridine synthase activity, enzyme-directed rRNA pseudouridine synthesis Indicus|evm.model.CM009515.1.51 Q8WVB6 CTF18_HUMAN 76.931 0.997957 1.0041 CHTF18 - Chromosome transmission fidelity protein 18 homolog - Homo sapiens (Human) - CHTF18 gene Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). Indicus|evm.model.CM009515.1.52 Q9JMF3 GBG13_MOUSE 95.522 0.970588 1.01493 Gng13 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 precursor - Mus musculus (Mouse) - Gng13 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009515.1.55 Q0P5C0 LMF1_BOVIN 98.236 0.984348 1.02496 LMF1 - Lipase maturation factor 1 - Bos taurus (Bovine) - LMF1 gene Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL (By similarity). Indicus|evm.model.CM009515.1.56 Q04886 SOX8_MOUSE 89.079 0.861682 1.15302 Sox8 - Transcription factor SOX-8 - Mus musculus (Mouse) - Sox8 gene Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. Indicus|evm.model.CM009515.1.57 F1MV99 SSR5_BOVIN 100.000 0.99458 1.00272 SSTR5 - Somatostatin receptor type 5 - Bos taurus (Bovine) - SSTR5 gene Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization (By similarity). Indicus|evm.model.CM009515.1.58 P60827 C1QT8_HUMAN 82.305 0.940476 1 C1QTNF8 - Complement C1q tumor necrosis factor-related protein 8 precursor - Homo sapiens (Human) - C1QTNF8 gene May play a role as ligand of RXFP1. Indicus|evm.model.CM009515.1.59 Q2TA38 TEKT4_BOVIN 100.000 0.995536 1.00224 TEKT4 - Tektin-4 - Bos taurus (Bovine) - TEKT4 gene May be a structural component of the sperm flagellum. Contributes to normal sperm motility. Indicus|evm.model.CM009515.1.62 Q9EQ60 CAC1H_RAT 81.449 0.9991 0.941925 Cacna1h - Voltage-dependent T-type calcium channel subunit alpha-1H - Rattus norvegicus (Rat) - Cacna1h gene Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:11073957). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (By similarity). Indicus|evm.model.CM009515.1.63 Q9XSM2 TRYT_SHEEP 83.922 0.933824 0.996337 Tryptase-2 precursor - Ovis aries (Sheep) Indicus|evm.model.CM009515.1.64 Q9XSM2 TRYT_SHEEP 87.059 0.849498 1.09524 Tryptase-2 precursor - Ovis aries (Sheep) Indicus|evm.model.CM009515.1.66 P19236 TRYM_CANLF 61.929 0.815126 0.85 Mastin precursor - Canis lupus familiaris (Dog) Indicus|evm.model.CM009515.1.67 P19236 TRYM_CANLF 61.210 0.726562 1.37143 Mastin precursor - Canis lupus familiaris (Dog) Indicus|evm.model.CM009515.1.68 Q28CQ4 UBC9_XENTR 100.000 0.987421 1.00633 ube2i - SUMO-conjugating enzyme UBC9 - Xenopus tropicalis (Western clawed frog) - ube2i gene Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation. Indicus|evm.model.CM009515.1.69 O94812 BAIP3_HUMAN 88.976 0.998265 0.971356 BAIAP3 - BAI1-associated protein 3 - Homo sapiens (Human) - BAIAP3 gene Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (PubMed:28626000). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity). Indicus|evm.model.CM009515.1.70 Q9UJK0 TSR3_HUMAN 82.857 0.993671 1.01282 TSR3 - 18S rRNA aminocarboxypropyltransferase - Homo sapiens (Human) - TSR3 gene Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable). Indicus|evm.model.CM009515.1.71 Q58CS8 GNPTG_BOVIN 99.673 0.993485 1.00327 GNPTG - N-acetylglucosamine-1-phosphotransferase subunit gamma precursor - Bos taurus (Bovine) - GNPTG gene Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors (By similarity). Indicus|evm.model.CM009515.1.72 Q5FWH2 UNKL_MOUSE 82.320 0.969739 1 Unkl - Putative E3 ubiquitin-protein ligase UNKL - Mus musculus (Mouse) - Unkl gene May participate in a protein complex showing an E3 ligase activity regulated by Rac1. Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2. Intrinsic E3 ligase activity has not been proven. Indicus|evm.model.CM009515.1.73 Q1ECT8 CSMT1_BOVIN 98.519 0.985294 1.00741 CCSMST1 - Protein CCSMST1 precursor - Bos taurus (Bovine) - CCSMST1 gene Indicus|evm.model.CM009515.1.75 A0A1W2PR82 PERC1_HUMAN 64.338 0.766764 1.28464 PERCC1 - Protein PERCC1 - Homo sapiens (Human) - PERCC1 gene Plays a critical role in intestinal function (PubMed:31217582). Acts by promoting the development of enteroendocrine cells (EECs) of the gastrointestinal tract and pancreas (By similarity). It is thereby required for normal enteroendocrine peptide hormone secretion (By similarity). Indicus|evm.model.CM009515.1.76 Q6RUT8 CC154_MOUSE 67.036 0.931852 1.01657 Ccdc154 - Coiled-coil domain-containing protein 154 - Mus musculus (Mouse) - Ccdc154 gene bone mineralization involved in bone maturation, bone resorption, odontogenesis of dentin-containing tooth, tooth eruption Indicus|evm.model.CM009515.1.77 Q4PKH3 CLCN7_BOVIN 98.577 0.932367 1.02349 CLCN7 - H(+)/Cl(-) exchange transporter 7 - Bos taurus (Bovine) - CLCN7 gene Slowly voltage-gated channel mediating the exchange of chloride ions against protons (By similarity). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). Indicus|evm.model.CM009515.1.79 Q96A99 PTX4_HUMAN 65.979 0.995736 0.981172 PTX4 - Pentraxin-4 precursor - Homo sapiens (Human) - PTX4 gene Indicus|evm.model.CM009515.1.80 Q9Y4R8 TELO2_HUMAN 74.194 0.840717 1.13262 TELO2 - Telomere length regulation protein TEL2 homolog - Homo sapiens (Human) - TELO2 gene Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. Indicus|evm.model.CM009515.1.81 E9PY46 IF140_MOUSE 80.414 0.989026 0.995902 Ift140 - Intraflagellar transport protein 140 homolog - Mus musculus (Mouse) - Ift140 gene Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (By similarity). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22282595). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (PubMed:24619649). Indicus|evm.model.CM009515.1.83 Q96RY5 CRML_HUMAN 84.338 0.970274 1.03388 CRAMP1 - Protein cramped-like - Homo sapiens (Human) - CRAMP1 gene nucleus, chromatin binding, pattern specification process Indicus|evm.model.CM009515.1.84 Q9H910 JUPI2_HUMAN 75.789 0.989071 0.963158 JPT2 - Jupiter microtubule associated homolog 2 - Homo sapiens (Human) - JPT2 gene cytosol, plasma membrane Indicus|evm.model.CM009515.1.85 Q9UPT6 JIP3_HUMAN 93.558 0.998501 0.998503 MAPK8IP3 - C-Jun-amino-terminal kinase-interacting protein 3 - Homo sapiens (Human) - MAPK8IP3 gene The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). Indicus|evm.model.CM009515.1.86 Q13232 NDK3_HUMAN 95.266 0.988235 1.00592 NME3 - Nucleoside diphosphate kinase 3 - Homo sapiens (Human) - NME3 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis. Indicus|evm.model.CM009515.1.87 P82929 RT34_BOVIN 100.000 0.990868 1.00459 MRPS34 - 28S ribosomal protein S34, mitochondrial - Bos taurus (Bovine) - MRPS34 gene Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation. Indicus|evm.model.CM009515.1.88 A4GXA9 EME2_HUMAN 73.879 0.994638 0.984169 EME2 - Probable crossover junction endonuclease EME2 - Homo sapiens (Human) - EME2 gene Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. Indicus|evm.model.CM009515.1.89 Q3MHZ2 SPSB3_BOVIN 100.000 0.99422 1.0029 SPSB3 - SPRY domain-containing SOCS box protein 3 - Bos taurus (Bovine) - SPSB3 gene May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009515.1.90 Q3MHY6 NUBP2_BOVIN 99.631 0.992647 1.00369 NUBP2 - Cytosolic Fe-S cluster assembly factor NUBP2 - Bos taurus (Bovine) - NUBP2 gene Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure. Indicus|evm.model.CM009515.1.91 P35858 ALS_HUMAN 76.481 0.964052 1.01157 IGFALS - Insulin-like growth factor-binding protein complex acid labile subunit precursor - Homo sapiens (Human) - IGFALS gene Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion. Indicus|evm.model.CM009515.1.92 Q3B7M2 GLO2_BOVIN 100.000 0.993528 1.00325 HAGH - Hydroxyacylglutathione hydrolase, mitochondrial precursor - Bos taurus (Bovine) - HAGH gene Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. Indicus|evm.model.CM009515.1.93 Q2HJ98 FAHD1_BOVIN 100.000 0.990991 1.00452 FAHD1 - Acylpyruvase FAHD1, mitochondrial precursor - Bos taurus (Bovine) - FAHD1 gene Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Also has oxaloacetate decarboxylase activity. Indicus|evm.model.CM009515.1.94 Q4R8G6 MEIOB_MACFA 86.412 0.991561 1.00637 MEIOB - Meiosis-specific with OB domain-containing protein - Macaca fascicularis (Crab-eating macaque) - MEIOB gene Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro. Indicus|evm.model.CM009515.1.95 Q5GFD5 HS3S6_MOUSE 90.093 0.938776 1.00292 Hs3st6 - Heparan sulfate glucosamine 3-O-sulfotransferase 6 - Mus musculus (Mouse) - Hs3st6 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Indicus|evm.model.CM009515.1.96 Q3MHL9 MSRB1_BOVIN 98.936 0.978947 0.818966 MSRB1 - Methionine-R-sulfoxide reductase B1 - Bos taurus (Bovine) - MSRB1 gene Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. Indicus|evm.model.CM009515.1.97 Q3SZ10 RL3L_BOVIN 100.000 0.995098 1.00246 RPL3L - 60S ribosomal protein L3-like - Bos taurus (Bovine) - RPL3L gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome, ribosomal large subunit assembly Indicus|evm.model.CM009515.1.98 Q02373 NDUBA_BOVIN 100.000 0.988701 1.00568 NDUFB10 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 - Bos taurus (Bovine) - NDUFB10 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009515.1.99 O18789 RS2_BOVIN 100.000 0.993197 1.00341 RPS2 - 40S ribosomal protein S2 - Bos taurus (Bovine) - RPS2 gene cytosolic small ribosomal subunit, structural constituent of ribosome, translation Indicus|evm.model.CM009515.1.100 Q2TBT8 RN151_BOVIN 99.567 0.207394 4.62083 RNF151 - RING finger protein 151 - Bos taurus (Bovine) - RNF151 gene ubiquitin protein ligase activity, protein ubiquitination Indicus|evm.model.CM009515.1.101 Q8NFA2 NOXO1_HUMAN 66.571 0.874036 1.03457 NOXO1 - NADPH oxidase organizer 1 - Homo sapiens (Human) - NOXO1 gene Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. Indicus|evm.model.CM009515.1.102 P55789 ALR_HUMAN 83.495 0.990291 1.00488 GFER - FAD-linked sulfhydryl oxidase ALR - Homo sapiens (Human) - GFER gene FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Indicus|evm.model.CM009515.1.103 A2VE58 SNG3_BOVIN 100.000 0.991304 1.00437 SYNGR3 - Synaptogyrin-3 - Bos taurus (Bovine) - SYNGR3 gene May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal. Indicus|evm.model.CM009515.1.104 Q86UK7 ZN598_HUMAN 80.148 0.899329 0.988938 ZNF598 - E3 ubiquitin-protein ligase ZNF598 - Homo sapiens (Human) - ZNF598 gene E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). Indicus|evm.model.CM009515.1.105 Q15599 NHRF2_HUMAN 92.881 0.493289 1.76855 SLC9A3R2 - Na(+)/H(+) exchange regulatory cofactor NHE-RF2 - Homo sapiens (Human) - SLC9A3R2 gene Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. Indicus|evm.model.CM009515.1.106 Q2KID2 NTH_BOVIN 100.000 0.993464 1.00328 NTHL1 - Endonuclease III-like protein 1 precursor - Bos taurus (Bovine) - NTHL1 gene Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Indicus|evm.model.CM009515.1.107 P49815 TSC2_HUMAN 90.094 0.998884 0.991699 TSC2 - Tuberin - Homo sapiens (Human) - TSC2 gene In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). Indicus|evm.model.CM009515.1.108 P98161 PKD1_HUMAN 79.197 0.993837 0.980479 PKD1 - Polycystin-1 precursor - Homo sapiens (Human) - PKD1 gene Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Both PKD1 and PKD2 are required for channel activity (PubMed:27214281). Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Indicus|evm.model.CM009515.1.109 Q29RR0 RAB26_BOVIN 100.000 0.992218 1.00391 RAB26 - Ras-related protein Rab-26 - Bos taurus (Bovine) - RAB26 gene Participates in exocrine secretion: regulates the secretion of acinar granules in the parotid gland. Indicus|evm.model.CM009515.1.110 Q922B6 TRAF7_MOUSE 98.653 0.885075 1.12795 Traf7 - E3 ubiquitin-protein ligase TRAF7 - Mus musculus (Mouse) - Traf7 gene E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Indicus|evm.model.CM009515.1.111 Q8WXD9 CSKI1_HUMAN 89.314 0.950683 0.921034 CASKIN1 - Caskin-1 - Homo sapiens (Human) - CASKIN1 gene May link the scaffolding protein CASK to downstream intracellular effectors. Indicus|evm.model.CM009515.1.112 Q17QU5 LST8_BOVIN 100.000 0.993884 1.00307 MLST8 - Target of rapamycin complex subunit LST8 - Bos taurus (Bovine) - MLST8 gene Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657' (By similarity). Indicus|evm.model.CM009515.1.113 Q2T9S4 PGP_BOVIN 99.262 0.453782 1.85358 PGP - Glycerol-3-phosphate phosphatase - Bos taurus (Bovine) - PGP gene Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP. Indicus|evm.model.CM009515.1.114 Q66K89 E4F1_HUMAN 88.662 0.997446 0.998724 E4F1 - Transcription factor E4F1 - Homo sapiens (Human) - E4F1 gene May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. Indicus|evm.model.CM009515.1.115 Q9D1G0 DNSL2_MOUSE 82.014 0.992832 1.0036 Dnase1l2 - Deoxyribonuclease-1-like 2 precursor - Mus musculus (Mouse) - Dnase1l2 gene Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells (By similarity). Indicus|evm.model.CM009515.1.116 P42126 ECI1_HUMAN 77.888 0.993421 1.00662 ECI1 - Enoyl-CoA delta isomerase 1, mitochondrial precursor - Homo sapiens (Human) - ECI1 gene Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Indicus|evm.model.CM009515.1.117 A6QR16 RNPS1_BOVIN 100.000 0.993464 1.00328 RNPS1 - RNA-binding protein with serine-rich domain 1 - Bos taurus (Bovine) - RNPS1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity). Indicus|evm.model.CM009515.1.118 Q99758 ABCA3_HUMAN 88.961 0.99824 1.00059 ABCA3 - Phospholipid-transporting ATPase ABCA3 - Homo sapiens (Human) - ABCA3 gene Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:28887056, PubMed:31473345, PubMed:27177387). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed:26903515, PubMed:25817392, PubMed:27177387). Indicus|evm.model.CM009515.1.119 E9PU17 ABCAH_RAT 65.940 0.952756 1.00282 Abca17 - ATP-binding cassette sub-family A member 17 - Rattus norvegicus (Rat) - Abca17 gene Promotes cholesterol efflux from sperm which renders sperm capable of fertilization. Has also been shown to decrease levels of intracellular esterified neutral lipids including cholesteryl esters, fatty acid esters and triacylglycerols. Indicus|evm.model.CM009515.1.120 A5PK16 CCNF_BOVIN 99.746 0.647204 1.54315 CCNF - Cyclin-F - Bos taurus (Bovine) - CCNF gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Indicus|evm.model.CM009515.1.121 O00634 NET3_HUMAN 95.775 0.959184 0.253448 NTN3 - Netrin-3 precursor - Homo sapiens (Human) - NTN3 gene Netrins control guidance of CNS commissural axons and peripheral motor axons. Indicus|evm.model.CM009515.1.122 Q29RJ2 TBC24_BOVIN 98.246 0.913357 1.07364 TBC1D24 - TBC1 domain family member 24 - Bos taurus (Bovine) - TBC1D24 gene May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking. Indicus|evm.model.CM009515.1.123 P23956 VATL_BOVIN 100.000 0.987179 1.00645 ATP6V0C - V-type proton ATPase 16 kDa proteolipid subunit - Bos taurus (Bovine) - ATP6V0C gene Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Indicus|evm.model.CM009515.1.124 A7MBC0 NAGA_BOVIN 100.000 0.995122 1.00244 AMDHD2 - N-acetylglucosamine-6-phosphate deacetylase - Bos taurus (Bovine) - AMDHD2 gene Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Indicus|evm.model.CM009515.1.127 O15530 PDPK1_HUMAN 95.849 0.996234 0.955036 PDPK1 - 3-phosphoinositide-dependent protein kinase 1 - Homo sapiens (Human) - PDPK1 gene Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive. Indicus|evm.model.CM009515.1.128 A5PKG7 KCTD5_BOVIN 100.000 0.721003 1.36325 KCTD5 - BTB/POZ domain-containing protein KCTD5 - Bos taurus (Bovine) - KCTD5 gene Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (By similarity). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity). Indicus|evm.model.CM009515.1.129 Q9BQR3 PRS27_HUMAN 82.156 0.858974 1.07586 PRSS27 - Serine protease 27 precursor - Homo sapiens (Human) - PRSS27 gene Indicus|evm.model.CM009515.1.130 Q9GZN4 BSSP4_HUMAN 78.808 0.923313 1.02839 PRSS22 - Brain-specific serine protease 4 precursor - Homo sapiens (Human) - PRSS22 gene Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. Indicus|evm.model.CM009515.1.131 Q96DA0 ZG16B_HUMAN 53.125 0.563636 0.264423 ZG16B - Zymogen granule protein 16 homolog B precursor - Homo sapiens (Human) - ZG16B gene extracellular exosome, extracellular space, retina homeostasis Indicus|evm.model.CM009515.1.132 Q96DA0 ZG16B_HUMAN 52.761 0.47093 1.65385 ZG16B - Zymogen granule protein 16 homolog B precursor - Homo sapiens (Human) - ZG16B gene extracellular exosome, extracellular space, retina homeostasis Indicus|evm.model.CM009515.1.133 Q96DA0 ZG16B_HUMAN 52.174 0.867089 0.759615 ZG16B - Zymogen granule protein 16 homolog B precursor - Homo sapiens (Human) - ZG16B gene extracellular exosome, extracellular space, retina homeostasis Indicus|evm.model.CM009515.1.134 P0DP42 T225B_HUMAN 71.429 0.989848 0.891403 TMEM225B - Transmembrane protein 225B - Homo sapiens (Human) - TMEM225B gene Indicus|evm.model.CM009515.1.135 Q9Y6M0 TEST_HUMAN 65.979 0.888545 1.02866 PRSS21 - Testisin precursor - Homo sapiens (Human) - PRSS21 gene Could regulate proteolytic events associated with testicular germ cell maturation. Indicus|evm.model.CM009515.1.136 Q7RTY9 PRS41_HUMAN 58.238 0.796923 1.02201 PRSS41 - Serine protease 41 precursor - Homo sapiens (Human) - PRSS41 gene extracellular region, intracellular organelle, plasma membrane, sodium channel regulator activity Indicus|evm.model.CM009515.1.137 Q15370 ELOB_HUMAN 97.222 0.305714 2.9661 ELOB - Elongin-B - Homo sapiens (Human) - ELOB gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). Indicus|evm.model.CM009515.1.138 Q9UQ35 SRRM2_HUMAN 83.916 0.434719 0.996366 SRRM2 - Serine/arginine repetitive matrix protein 2 - Homo sapiens (Human) - SRRM2 gene Required for pre-mRNA splicing as component of the spliceosome. Indicus|evm.model.CM009515.1.139 Q9CQE9 FWCH2_MOUSE 84.746 0.793103 1.04317 Flywch2 - FLYWCH family member 2 - Mus musculus (Mouse) - Flywch2 gene Indicus|evm.model.CM009515.1.140 Q4VC44 FWCH1_HUMAN 77.040 0.997211 1.0014 FLYWCH1 - FLYWCH-type zinc finger-containing protein 1 - Homo sapiens (Human) - FLYWCH1 gene cytosol, nuclear body, nucleoplasm Indicus|evm.model.CM009515.1.141 Q8K1S7 KREM2_MOUSE 97.927 0.521739 0.798265 Kremen2 - Kremen protein 2 precursor - Mus musculus (Mouse) - Kremen2 gene Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822). Indicus|evm.model.CM009515.1.142 Q8N4S7 PAQR4_HUMAN 94.139 0.992701 1.00366 PAQR4 - Progestin and adipoQ receptor family member 4 - Homo sapiens (Human) - PAQR4 gene signaling receptor activity Indicus|evm.model.CM009515.1.143 Q99640 PMYT1_HUMAN 89.336 0.995984 0.997996 PKMYT1 - Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase - Homo sapiens (Human) - PKMYT1 gene Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Indicus|evm.model.CM009515.1.146 O95484 CLD9_HUMAN 96.774 0.990826 1.00461 CLDN9 - Claudin-9 - Homo sapiens (Human) - CLDN9 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009515.1.147 P56747 CLD6_HUMAN 90.950 0.990991 1.00909 CLDN6 - Claudin-6 - Homo sapiens (Human) - CLDN6 gene Plays a major role in tight junction-specific obliteration of the intercellular space. Indicus|evm.model.CM009515.1.148 Q9NP84 TNR12_HUMAN 88.785 0.815385 1.00775 TNFRSF12A - Tumor necrosis factor receptor superfamily member 12A precursor - Homo sapiens (Human) - TNFRSF12A gene Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Indicus|evm.model.CM009515.1.149 Q9NWW0 HPIP_HUMAN 88.406 0.985612 1.00725 HCFC1R1 - Host cell factor C1 regulator 1 - Homo sapiens (Human) - HCFC1R1 gene Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. Indicus|evm.model.CM009515.1.150 Q86W42 THOC6_HUMAN 95.894 0.994152 1.00293 THOC6 - THO complex subunit 6 homolog - Homo sapiens (Human) - THOC6 gene Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. Indicus|evm.model.CM009515.1.151 A1A5D9 BICL2_HUMAN 85.265 0.996055 0.998031 BICDL2 - BICD family-like cargo adapter 2 - Homo sapiens (Human) - BICDL2 gene Golgi to secretory granule transport, vesicle transport along microtubule Indicus|evm.model.CM009515.1.152 Q9NPA2 MMP25_HUMAN 85.158 0.960644 0.994662 MMP25 - Matrix metalloproteinase-25 precursor - Homo sapiens (Human) - MMP25 gene May activate progelatinase A. Indicus|evm.model.CM009515.1.156 Q96SZ4 ZSC10_HUMAN 79.070 0.926302 1.08552 ZSCAN10 - Zinc finger and SCAN domain-containing protein 10 - Homo sapiens (Human) - ZSCAN10 gene Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4. Indicus|evm.model.CM009515.1.157 Q58DK7 ZN205_BOVIN 99.091 0.99637 1.00182 ZNF205 - Zinc finger protein 205 - Bos taurus (Bovine) - ZNF205 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.158 O14771 ZN213_HUMAN 75.180 0.305804 1.95207 ZNF213 - Zinc finger protein 213 - Homo sapiens (Human) - ZNF213 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.159 P98182 ZN200_HUMAN 85.823 0.994924 0.997468 ZNF200 - Zinc finger protein 200 - Homo sapiens (Human) - ZNF200 gene Could have a role in spermatogenesis. Indicus|evm.model.CM009515.1.160 O15553 MEFV_HUMAN 54.762 0.995522 0.857875 MEFV - Pyrin - Homo sapiens (Human) - MEFV gene Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). Indicus|evm.model.CM009515.1.161 O14978 ZN263_HUMAN 86.186 0.962319 0.505124 ZNF263 - Zinc finger protein 263 - Homo sapiens (Human) - ZNF263 gene Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). Indicus|evm.model.CM009515.1.162 Q6NT04 TIGD7_HUMAN 91.268 0.967213 0.666667 TIGD7 - Tigger transposable element-derived protein 7 - Homo sapiens (Human) - TIGD7 gene nucleus, DNA binding Indicus|evm.model.CM009515.1.163 Q96N20 ZN75A_HUMAN 82.412 0.327273 2.04392 ZNF75A - Zinc finger protein 75A - Homo sapiens (Human) - ZNF75A gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.164 Q5R4A5 SNX17_PONAB 48.659 0.990338 0.440426 SNX17 - Sorting nexin-17 - Pongo abelii (Sumatran orangutan) - SNX17 gene Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). Indicus|evm.model.CM009515.1.165 Q96N20 ZN75A_HUMAN 81.343 0.551867 1.62838 ZNF75A - Zinc finger protein 75A - Homo sapiens (Human) - ZNF75A gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.167 Q15697 ZN174_HUMAN 83.659 0.995086 1 ZNF174 - Zinc finger protein 174 - Homo sapiens (Human) - ZNF174 gene Transcriptional repressor. Indicus|evm.model.CM009515.1.168 Q17QK9 NAA60_BOVIN 87.891 0.992188 1.05785 NAA60 - N-alpha-acetyltransferase 60 - Bos taurus (Bovine) - NAA60 gene N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences. Indicus|evm.model.CM009515.1.169 Q32LI1 CP090_BOVIN 92.973 0.989247 1.06286 Uncharacterized protein C16orf90 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009515.1.170 Q6AYJ5 CLUA1_RAT 85.748 0.970387 1.09204 Cluap1 - Clusterin-associated protein 1 - Rattus norvegicus (Rat) - Cluap1 gene Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. Indicus|evm.model.CM009515.1.171 Q7RTR2 NLRC3_HUMAN 85.352 0.998124 1.00094 NLRC3 - NLR family CARD domain-containing protein 3 - Homo sapiens (Human) - NLRC3 gene Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106). Indicus|evm.model.CM009515.1.172 Q8IY92 SLX4_HUMAN 60.209 0.945464 1.00981 SLX4 - Structure-specific endonuclease subunit SLX4 - Homo sapiens (Human) - SLX4 gene Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. Indicus|evm.model.CM009515.1.173 P00639 DNAS1_BOVIN 98.936 0.479522 2.07801 DNASE1 - Deoxyribonuclease-1 precursor - Bos taurus (Bovine) - DNASE1 gene Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:4976790, PubMed:5166750, PubMed:3352748, PubMed:2395459). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:2395459). Binds specifically to G-actin and blocks actin polymerization (PubMed:2395459). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). Indicus|evm.model.CM009515.1.174 Q2TBI4 TRAP1_BOVIN 99.573 0.997155 1 TRAP1 - Heat shock protein 75 kDa, mitochondrial precursor - Bos taurus (Bovine) - TRAP1 gene Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. Indicus|evm.model.CM009515.1.175 Q92793 CBP_HUMAN 94.438 0.999179 0.997543 CREBBP - CREB-binding protein - Homo sapiens (Human) - CREBBP gene Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). Indicus|evm.model.CM009515.1.176 O60503 ADCY9_HUMAN 91.346 0.997048 1.00148 ADCY9 - Adenylate cyclase type 9 - Homo sapiens (Human) - ADCY9 gene Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). Indicus|evm.model.CM009515.1.177 Q3T0D6 LEG4_BOVIN 83.133 0.993056 0.86747 LGALS4 - Galectin-4 - Bos taurus (Bovine) - LGALS4 gene Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions (By similarity). Indicus|evm.model.CM009515.1.178 P13666 SRCA_RABIT 96.923 0.573232 1.67797 SRL - Sarcalumenin precursor - Oryctolagus cuniculus (Rabbit) - SRL gene Indicus|evm.model.CM009515.1.179 Q01664 TFAP4_HUMAN 94.970 0.994048 0.994083 TFAP4 - Transcription factor AP-4 - Homo sapiens (Human) - TFAP4 gene Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. Indicus|evm.model.CM009515.1.180 Q9BZE0 GLIS2_HUMAN 94.847 0.99619 1.00191 GLIS2 - Zinc finger protein GLIS2 - Homo sapiens (Human) - GLIS2 gene Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). Indicus|evm.model.CM009515.1.181 Q0V8F1 CORO7_BOVIN 99.131 0.879541 1.14317 CORO7 - Coronin-7 - Bos taurus (Bovine) - CORO7 gene F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity). Indicus|evm.model.CM009515.1.182 Q96EY1 DNJA3_HUMAN 90.000 0.995842 1.00208 DNAJA3 - DnaJ homolog subfamily A member 3, mitochondrial precursor - Homo sapiens (Human) - DNAJA3 gene Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Indicus|evm.model.CM009515.1.183 Q0VCN1 NMRL1_BOVIN 98.662 0.993333 1.00334 NMRAL1 - NmrA-like family domain-containing protein 1 - Bos taurus (Bovine) - NMRAL1 gene Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer (By similarity). Indicus|evm.model.CM009515.1.184 P30519 HMOX2_HUMAN 80.838 0.840909 1.25316 HMOX2 - Heme oxygenase 2 - Homo sapiens (Human) - HMOX2 gene Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Indicus|evm.model.CM009515.1.185 Q58D45 CDIP1_BOVIN 99.438 0.808219 1.05288 CDIP1 - Cell death-inducing p53-target protein 1 - Bos taurus (Bovine) - CDIP1 gene Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner. Indicus|evm.model.CM009515.1.187 A6NNT2 CP096_HUMAN 62.298 0.562956 0.960561 C16orf96 - Uncharacterized protein C16orf96 - Homo sapiens (Human) - C16orf96 gene Indicus|evm.model.CM009515.1.188 Q8TB05 UBAD1_HUMAN 81.461 0.987179 0.881356 UBALD1 - UBA-like domain-containing protein 1 - Homo sapiens (Human) - UBALD1 gene Indicus|evm.model.CM009515.1.189 O60291 MGRN1_HUMAN 86.705 0.927273 0.996377 MGRN1 - E3 ubiquitin-protein ligase MGRN1 - Homo sapiens (Human) - MGRN1 gene E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). Indicus|evm.model.CM009515.1.191 Q9BRJ7 TIRR_HUMAN 97.156 0.990566 1.00474 NUDT16L1 - Tudor-interacting repair regulator protein - Homo sapiens (Human) - NUDT16L1 gene Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299). Indicus|evm.model.CM009515.1.192 Q5M9H0 ANKS3_RAT 85.197 0.963415 0.989442 Anks3 - Ankyrin repeat and SAM domain-containing protein 3 - Rattus norvegicus (Rat) - Anks3 gene May be involved in vasopressin signaling in the kidney. Indicus|evm.model.CM009515.1.193 Q2KIS6 DAAP1_BOVIN 98.058 0.629857 1.35457 DNAAF8 - Dynein axonemal assembly factor 8 - Bos taurus (Bovine) - DNAAF8 gene In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits. Indicus|evm.model.CM009515.1.194 O60304 ZN500_HUMAN 67.063 0.799669 1.25833 ZNF500 - Zinc finger protein 500 - Homo sapiens (Human) - ZNF500 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.195 A5D7Q3 SEP12_BOVIN 99.446 0.994475 1.00277 SEPTIN12 - Septin-12 - Bos taurus (Bovine) - SEPTIN12 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Indicus|evm.model.CM009515.1.197 Q148F6 ROGDI_BOVIN 98.955 0.993056 1.00348 ROGDI - Protein rogdi homolog - Bos taurus (Bovine) - ROGDI gene RAVE complex Indicus|evm.model.CM009515.1.198 A4FUF0 GLYR1_BOVIN 100.000 0.99639 1.00181 GLYR1 - Putative oxidoreductase GLYR1 - Bos taurus (Bovine) - GLYR1 gene Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Facilitates Pol II transcription through nucleosomes. Binds DNA (in vitro). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Promotes KDM1B demethylase activity. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Putative oxidoreductase. Indicus|evm.model.CM009515.1.199 Q9NPG3 UBN1_HUMAN 85.852 0.998236 1 UBN1 - Ubinuclein-1 - Homo sapiens (Human) - UBN1 gene Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. Indicus|evm.model.CM009515.1.200 O60437 PEPL_HUMAN 84.598 0.98356 1.00456 PPL - Periplakin - Homo sapiens (Human) - PPL gene Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. Indicus|evm.model.CM009515.1.201 O43304 S14L5_HUMAN 87.519 0.965517 1 SEC14L5 - SEC14-like protein 5 - Homo sapiens (Human) - SEC14L5 gene Indicus|evm.model.CM009515.1.202 P68827 NAGPA_BOVIN 88.246 0.996491 1.08159 NAGPA - N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor - Bos taurus (Bovine) - NAGPA gene Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. Indicus|evm.model.CM009515.1.203 Q6UX73 CP089_HUMAN 73.101 0.870166 0.900498 C16orf89 - UPF0764 protein C16orf89 precursor - Homo sapiens (Human) - C16orf89 gene cytosol, extracellular exosome, membrane, protein homodimerization activity Indicus|evm.model.CM009515.1.204 Q5R7A2 ALG1_PONAB 83.521 0.950538 1.00216 ALG1 - Chitobiosyldiphosphodolichol beta-mannosyltransferase - Pongo abelii (Sumatran orangutan) - ALG1 gene Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity). Indicus|evm.model.CM009515.1.205 Q1JPJ9 EF2KT_BOVIN 98.824 0.994135 1.00294 EEF2KMT - Protein-lysine N-methyltransferase EEF2KMT - Bos taurus (Bovine) - EEF2KMT gene Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. Indicus|evm.model.CM009515.1.206 Q6UWV6 ENPP7_HUMAN 51.515 0.72 1.0917 ENPP7 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor - Homo sapiens (Human) - ENPP7 gene Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:12885774, PubMed:12671034, PubMed:15205117, PubMed:16255717, PubMed:28292932). Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation (PubMed:16255717, PubMed:12885774). Does not have nucleotide pyrophosphatase activity (PubMed:12885774). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity). Indicus|evm.model.CM009515.1.209 Q4R7Y2 RL10_MACFA 62.366 0.867925 0.495327 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009515.1.212 P62752 RL23A_RAT 67.273 0.327273 1.05769 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009515.1.215 Q9NWB1 RFOX1_HUMAN 98.454 0.934783 1.04282 RBFOX1 - RNA binding protein fox-1 homolog 1 - Homo sapiens (Human) - RBFOX1 gene RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Indicus|evm.model.CM009515.1.220 B3SHH9 TM114_HUMAN 86.996 0.991071 1.00448 TMEM114 - Transmembrane protein 114 - Homo sapiens (Human) - TMEM114 gene apical plasma membrane Indicus|evm.model.CM009515.1.221 Q8R1C6 MET22_MOUSE 78.295 0.954774 1.01272 Mettl22 - Methyltransferase-like protein 22 - Mus musculus (Mouse) - Mettl22 gene Protein N-lysine methyltransferase. In vitro methylates KIN (By similarity). Indicus|evm.model.CM009515.1.222 P80147 GABT_PIG 95.800 0.996008 1.002 ABAT - 4-aminobutyrate aminotransferase, mitochondrial precursor - Sus scrofa (Pig) - ABAT gene Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. Indicus|evm.model.CM009515.1.223 Q5EA03 TM186_BOVIN 99.528 0.99061 1.00472 TMEM186 - Transmembrane protein 186 - Bos taurus (Bovine) - TMEM186 gene mitochondrion Indicus|evm.model.CM009515.1.224 Q3SZJ9 PMM2_BOVIN 100.000 0.991903 1.00407 PMM2 - Phosphomannomutase 2 - Bos taurus (Bovine) - PMM2 gene Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. Indicus|evm.model.CM009515.1.225 Q9WU49 CHSP1_RAT 95.238 0.986486 1.0068 Carhsp1 - Calcium-regulated heat stable protein 1 - Rattus norvegicus (Rat) - Carhsp1 gene Binds mRNA and regulates the stability of target mRNA. Indicus|evm.model.CM009515.1.226 A0A1B0GVX0 LITAD_HUMAN 67.606 0.47619 2.04167 LITAFD - LITAF domain-containing protein - Homo sapiens (Human) - LITAFD gene Indicus|evm.model.CM009515.1.227 Q4VSI4 UBP7_RAT 99.052 0.998106 0.957389 Usp7 - Ubiquitin carboxyl-terminal hydrolase 7 - Rattus norvegicus (Rat) - Usp7 gene Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:16111684, PubMed:16328052). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (By similarity). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (By similarity). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (By similarity). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (By similarity). Deubiquitinates KMT2E preventing KMT2E proteasomal-mediated degradation (By similarity). Involved in cell proliferation during early embryonic development (By similarity). Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (By similarity). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (By similarity). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (By similarity). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (By similarity). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing transcription factor FOXP3 which is crucial for Treg cell function (By similarity). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (By similarity). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (By similarity). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (By similarity). Indicus|evm.model.CM009515.1.229 Q14CZ0 CP072_HUMAN 100.000 0.575145 1.25818 C16orf72 - UPF0472 protein C16orf72 - Homo sapiens (Human) - C16orf72 gene Indicus|evm.model.CM009515.1.233 P35436 NMDE1_MOUSE 94.689 0.912971 0.816257 Grin2a - Glutamate receptor ionotropic, NMDA 2A precursor - Mus musculus (Mouse) - Grin2a gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium (PubMed:1374164). Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (By similarity). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:7816096, PubMed:8987814). Indicus|evm.model.CM009515.1.234 Q5IS45 NMDE1_PANTR 92.647 0.465278 0.0983607 GRIN2A - Glutamate receptor ionotropic, NMDA 2A precursor - Pan troglodytes (Chimpanzee) - GRIN2A gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; cchannels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Indicus|evm.model.CM009515.1.235 Q00959 NMDE1_RAT 97.101 0.913333 0.102459 Grin2a - Glutamate receptor ionotropic, NMDA 2A precursor - Rattus norvegicus (Rat) - Grin2a gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed:28384476). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Indicus|evm.model.CM009515.1.239 Q5U623 MCAF2_HUMAN 69.784 0.997089 1.00733 ATF7IP2 - Activating transcription factor 7-interacting protein 2 - Homo sapiens (Human) - ATF7IP2 gene Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). Indicus|evm.model.CM009515.1.240 Q2NKU9 EMP2_BOVIN 98.802 0.988095 1.00599 EMP2 - Epithelial membrane protein 2 - Bos taurus (Bovine) - EMP2 gene Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity. Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion. Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation. Regulates cell migration and cell contraction through PTK2 and SRC activation. Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2. Positively regulates cell proliferation. Plays a role during cell death and cell blebbing. Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway. Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3. May play a role in glomerular filtration. Indicus|evm.model.CM009515.1.241 Q2YDI7 TEKT5_BOVIN 96.319 0.995781 0.969325 TEKT5 - Tektin-5 - Bos taurus (Bovine) - TEKT5 gene May be a structural component of the sperm flagellum. Indicus|evm.model.CM009515.1.242 Q24K00 NUBP1_BOVIN 95.312 0.993548 0.96875 NUBP1 - Cytosolic Fe-S cluster assembly factor NUBP1 - Bos taurus (Bovine) - NUBP1 gene Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure. Indicus|evm.model.CM009515.1.243 A6NH52 TV23A_HUMAN 90.094 0.689542 1.43662 TVP23A - Golgi apparatus membrane protein TVP23 homolog A - Homo sapiens (Human) - TVP23A gene integral component of Golgi membrane, protein secretion, vesicle-mediated transport Indicus|evm.model.CM009515.1.244 P33076 C2TA_HUMAN 77.046 0.927092 1.06814 CIITA - MHC class II transactivator - Homo sapiens (Human) - CIITA gene Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). Indicus|evm.model.CM009515.1.245 Q9WUQ7 DEXI_MOUSE 98.529 0.971014 0.726316 Dexi - Dexamethasone-induced protein - Mus musculus (Mouse) - Dexi gene Indicus|evm.model.CM009515.1.246 Q2KHT3 CL16A_HUMAN 92.395 0.99714 0.996201 CLEC16A - Protein CLEC16A - Homo sapiens (Human) - CLEC16A gene Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. Indicus|evm.model.CM009515.1.249 O15524 SOCS1_HUMAN 92.342 0.991031 1.05687 SOCS1 - Suppressor of cytokine signaling 1 - Homo sapiens (Human) - SOCS1 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through binding to JAKs and IFNGR1, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. Indicus|evm.model.CM009515.1.250 P26377 STP2_BOVIN 98.485 0.984962 1.00758 TNP2 - Nuclear transition protein 2 - Bos taurus (Bovine) - TNP2 gene Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Indicus|evm.model.CM009515.1.251 Q32PA2 PRM3_BOVIN 100.000 0.978723 1.01075 PRM3 - Protamine-3 - Bos taurus (Bovine) - PRM3 gene Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity). Indicus|evm.model.CM009515.1.252 P19782 PRM2_BOVIN 81.739 0.628378 1.28696 PRM2 - Protamine-2 - Bos taurus (Bovine) - PRM2 gene Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. Indicus|evm.model.CM009515.1.253 A5PJU7 RMI2_BOVIN 99.363 0.987342 1.00637 RMI2 - RecQ-mediated genome instability protein 2 - Bos taurus (Bovine) - RMI2 gene Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. Indicus|evm.model.CM009515.1.254 Q6ZTK2 YP015_HUMAN 73.184 0.142288 6.84909 Putative uncharacterized protein LOC400499 - Homo sapiens (Human) Indicus|evm.model.CM009515.1.255 P0C0T0 LITAF_RAT 91.925 0.987654 1.00621 Litaf - Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog - Rattus norvegicus (Rat) - Litaf gene Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines. May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10. Indicus|evm.model.CM009515.1.256 Q17Q87 SNN_BOVIN 100.000 0.693548 1.42529 SNN - Stannin - Bos taurus (Bovine) - SNN gene Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation. Indicus|evm.model.CM009515.1.257 A4FUW8 TXD11_BOVIN 96.238 0.99791 1 TXNDC11 - Thioredoxin domain-containing protein 11 - Bos taurus (Bovine) - TXNDC11 gene May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation (By similarity). Indicus|evm.model.CM009515.1.258 Q8IWR0 Z3H7A_HUMAN 93.930 0.865419 1.15551 ZC3H7A - Zinc finger CCCH domain-containing protein 7A - Homo sapiens (Human) - ZC3H7A gene May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. Indicus|evm.model.CM009515.1.260 A4FV97 RL1D1_BOVIN 99.793 0.995859 1.00207 RSL1D1 - Ribosomal L1 domain-containing protein 1 - Bos taurus (Bovine) - RSL1D1 gene Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. Indicus|evm.model.CM009515.1.261 P15170 ERF3A_HUMAN 99.198 0.780564 1.27856 GSPT1 - Eukaryotic peptide chain release factor GTP-binding subunit ERF3A - Homo sapiens (Human) - GSPT1 gene Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). Indicus|evm.model.CM009515.1.262 P49242 RS3A_RAT 47.917 0.967742 0.234848 Rps3a - 40S ribosomal protein S3a - Rattus norvegicus (Rat) - Rps3a gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009515.1.263 Q08DX0 SNX29_BOVIN 96.806 0.875761 1.0049 SNX29 - Sorting nexin-29 - Bos taurus (Bovine) - SNX29 gene Indicus|evm.model.CM009515.1.264 Q58DC0 CPPED_BOVIN 99.317 0.979866 0.952077 CPPED1 - Serine/threonine-protein phosphatase CPPED1 - Bos taurus (Bovine) - CPPED1 gene Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes (By similarity). Indicus|evm.model.CM009515.1.265 B4DS77 SHSA9_HUMAN 88.706 0.995122 0.966981 SHISA9 - Protein shisa-9 precursor - Homo sapiens (Human) - SHISA9 gene Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity). Indicus|evm.model.CM009515.1.266 Q92889 XPF_HUMAN 89.629 0.997819 1.00109 ERCC4 - DNA repair endonuclease XPF - Homo sapiens (Human) - ERCC4 gene Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. Indicus|evm.model.CM009515.1.267 Q15427 SF3B4_HUMAN 82.249 0.613971 0.641509 SF3B4 - Splicing factor 3B subunit 4 - Homo sapiens (Human) - SF3B4 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). Indicus|evm.model.CM009515.1.268 Q9ULH7 MRTFB_HUMAN 85.294 0.952734 0.991728 MRTFB - Myocardin-related transcription factor B - Homo sapiens (Human) - MRTFB gene Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. Indicus|evm.model.CM009515.1.269 P69341 PARN_BOVIN 99.721 0.994429 0.562696 PARN - Poly(A)-specific ribonuclease PARN - Bos taurus (Bovine) - PARN gene 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails (By similarity) (PubMed:10698948, PubMed:9736620). Also able to recognize poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (By similarity). Indicus|evm.model.CM009515.1.270 Q9NZS9 BFAR_HUMAN 90.444 0.995565 1.00222 BFAR - Bifunctional apoptosis regulator - Homo sapiens (Human) - BFAR gene Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Indicus|evm.model.CM009515.1.271 O15496 PA2GX_HUMAN 69.173 0.809816 0.987879 PLA2G10 - Group 10 secretory phospholipase A2 precursor - Homo sapiens (Human) - PLA2G10 gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:9188469, PubMed:12021277). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls (PubMed:12359733, PubMed:12021277). Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles (PubMed:12021277). Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (PubMed:12021277). Efficiently hydrolyzes and inactivates platelet activating factor (PAF), a potent lipid mediator present in oxidized LDL (PubMed:16962371). May act in an autocrine and paracrine manner. Secreted by lung epithelium, targets membrane phospholipids of infiltrating eosinophils, releasing arachidonate and boosting eicosanoid and cysteinyl leukotriene synthesis involved in airway inflammatory response (By similarity). Secreted by gut epithelium, hydrolyzes dietary and biliary phosphatidylcholines in the gastrointestinal lumen (By similarity). Plays a stem cell regulator role in colon epithelium. Within intracellular compartment, mediates Paneth-like cell differentiation and its stem cell supporting functions by inhibiting the Wnt signaling pathway in intestinal stem cell (ISC). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ISCs and tissue regeneration (By similarity). May participate in hair follicle morphogenesis by regulating phosphatidylethanolamines metabolism at the outermost epithelial layer and facilitating melanin synthesis (By similarity). By releasing lysophosphatidylcholines (LPCs) at sperm acrosome, controls sperm cell capacitation, acrosome reaction and overall fertility (By similarity). May promote neurite outgrowth in neuron fibers involved in nociception (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (PubMed:12359733). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). In pulmonary epithelium, may contribute to host defense response against adenoviral infection. Prevents adenovirus entry into host cells by hydrolyzing host cell plasma membrane, releasing C16:0 LPCs that inhibit virus-mediated membrane fusion and viral infection. Likely prevents adenoviral entry into the endosomes of host cells (PubMed:16146426). May play a role in maturation and activation of innate immune cells including macrophages, group 2 innate lymphoid cells and mast cells (By similarity). Indicus|evm.model.CM009515.1.273 O77768 HNRPC_RABIT 83.871 0.884058 0.22549 HNRNPC - Heterogeneous nuclear ribonucleoprotein C - Oryctolagus cuniculus (Rabbit) - HNRNPC gene Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing. Indicus|evm.model.CM009515.1.274 Q2M238 RN3P1_HUMAN 93.662 0.216258 4.28947 RRN3P1 - Putative RRN3-like protein RRN3P1 - Homo sapiens (Human) - RRN3P1 gene nucleus, RNA polymerase I core binding, RNA polymerase I general transcription initiation factor activity, transcription initiation from RNA polymerase I promoter Indicus|evm.model.CM009515.1.275 Q96AB6 NTAN1_HUMAN 94.194 0.993569 1.00323 NTAN1 - Protein N-terminal asparagine amidohydrolase - Homo sapiens (Human) - NTAN1 gene N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn. Indicus|evm.model.CM009515.1.276 A7MBC2 PDXD1_BOVIN 100.000 0.997462 1.00127 PDXDC1 - Pyridoxal-dependent decarboxylase domain-containing protein 1 - Bos taurus (Bovine) - PDXDC1 gene endoplasmic reticulum, sphinganine-1-phosphate aldolase activity, ameboidal-type cell migration, sphingolipid catabolic process Indicus|evm.model.CM009515.1.277 Q2KIK2 MP17L_BOVIN 98.469 0.989848 1.0051 MPV17L - Mpv17-like protein - Bos taurus (Bovine) - MPV17L gene Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes. Indicus|evm.model.CM009515.1.278 Q5R562 MERB1_PONAB 96.078 0.990244 1.0049 BMERB1 - bMERB domain-containing protein 1 - Pongo abelii (Sumatran orangutan) - BMERB1 gene Indicus|evm.model.CM009515.1.279 E1BP74 MARF1_BOVIN 99.254 0.998269 0.994834 MARF1 - Meiosis regulator and mRNA stability factor 1 - Bos taurus (Bovine) - MARF1 gene Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). Indicus|evm.model.CM009515.1.280 Q9NXR1 NDE1_HUMAN 92.429 0.910663 1.03582 NDE1 - Nuclear distribution protein nudE homolog 1 - Homo sapiens (Human) - NDE1 gene Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Indicus|evm.model.CM009515.1.281 P35748 MYH11_RABIT 95.081 0.998983 0.996957 MYH11 - Myosin-11 - Oryctolagus cuniculus (Rabbit) - MYH11 gene Muscle contraction. Indicus|evm.model.CM009515.1.282 Q96NB1 CEP20_HUMAN 82.184 0.988571 1.00575 CEP20 - Centrosomal protein 20 - Homo sapiens (Human) - CEP20 gene Involved in the biogenesis of cilia (PubMed:20551181). Required for the recruitment of PLK1 to centrosomes and S phase progression (PubMed:24018379). Indicus|evm.model.CM009515.1.283 Q8HXQ5 MRP1_BOVIN 98.954 0.980757 1.01895 ABCC1 - Multidrug resistance-associated protein 1 - Bos taurus (Bovine) - ABCC1 gene Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:12067707). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity). Indicus|evm.model.CM009515.1.284 O95255 MRP6_HUMAN 83.910 0.998671 1.00133 ABCC6 - ATP-binding cassette sub-family C member 6 - Homo sapiens (Human) - ABCC6 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644). Indicus|evm.model.CM009515.1.285 Q15155 NOMO1_HUMAN 94.992 0.995094 1.00082 NOMO1 - Nodal modulator 1 precursor - Homo sapiens (Human) - NOMO1 gene Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed:32820719). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN/Nicalin (By similarity). Indicus|evm.model.CM009515.1.287 O46471 RGS16_BOVIN 97.030 0.719424 0.688119 RGS16 - Regulator of G-protein signaling 16 - Bos taurus (Bovine) - RGS16 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals. Indicus|evm.model.CM009515.1.288 Q5QQ57 XYLT1_PANTR 81.768 0.586319 0.324868 XYLT1 - Xylosyltransferase 1 - Pan troglodytes (Chimpanzee) - XYLT1 gene Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal maturation of chondrocytes during bone development, normal onset of ossification and normal embryonic and postnatal skeleton development, especially of the long bones. Indicus|evm.model.CM009515.1.289 Q86Y38 XYLT1_HUMAN 97.252 0.995434 0.685089 XYLT1 - Xylosyltransferase 1 - Homo sapiens (Human) - XYLT1 gene Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (PubMed:15461586, PubMed:17189265, PubMed:24581741, PubMed:23982343). Required for normal embryonic and postnatal skeleton development, especially of the long bones (PubMed:24581741, PubMed:23982343). Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity). Indicus|evm.model.CM009515.1.290 P62246 RS15A_RAT 100.000 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Indicus|evm.model.CM009515.1.291 Q5R454 AR6P1_PONAB 97.044 0.990196 1.00493 ARL6IP1 - ADP-ribosylation factor-like protein 6-interacting protein 1 - Pongo abelii (Sumatran orangutan) - ARL6IP1 gene Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Indicus|evm.model.CM009515.1.292 Q96Q15 SMG1_HUMAN 98.907 0.999453 0.999454 SMG1 - Serine/threonine-protein kinase SMG1 - Homo sapiens (Human) - SMG1 gene Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. Indicus|evm.model.CM009515.1.293 Q6UXS0 CL19A_HUMAN 84.000 0.663102 1.375 CLEC19A - C-type lectin domain family 19 member A precursor - Homo sapiens (Human) - CLEC19A gene Indicus|evm.model.CM009515.1.294 Q5R8Q5 SYT17_PONAB 97.015 0.993631 0.993671 SYT17 - Synaptotagmin-17 - Pongo abelii (Sumatran orangutan) - SYT17 gene Plays a role in dendrite formation by melanocytes. Indicus|evm.model.CM009515.1.295 Q3MIP1 IPIL2_HUMAN 88.598 0.996248 0.996262 ITPRIPL2 - Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 precursor - Homo sapiens (Human) - ITPRIPL2 gene Indicus|evm.model.CM009515.1.296 Q2TBW2 COQ7_BOVIN 100.000 0.990826 1.00461 COQ7 - 5-demethoxyubiquinone hydroxylase, mitochondrial precursor - Bos taurus (Bovine) - COQ7 gene Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. Indicus|evm.model.CM009515.1.297 Q4R7U0 TMC7_MACFA 91.148 0.993122 1.00553 TMC7 - Transmembrane channel-like protein 7 - Macaca fascicularis (Crab-eating macaque) - TMC7 gene Probable ion channel. Indicus|evm.model.CM009515.1.298 Q6UXY8 TMC5_HUMAN 77.579 0.997988 0.988072 TMC5 - Transmembrane channel-like protein 5 - Homo sapiens (Human) - TMC5 gene Probable ion channel. Indicus|evm.model.CM009515.1.299 Q3T0T0 GDE1_BOVIN 100.000 0.993976 1.00302 GDE1 - Glycerophosphodiester phosphodiesterase 1 - Bos taurus (Bovine) - GDE1 gene Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and partipates to bioactive N-acylethanolamines biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (By similarity). Indicus|evm.model.CM009515.1.300 O43303 CP110_HUMAN 82.559 0.974773 0.979249 CCP110 - Centriolar coiled-coil protein of 110 kDa - Homo sapiens (Human) - CCP110 gene Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). Indicus|evm.model.CM009515.1.301 Q5R8N4 VP35L_PONAB 96.989 0.997925 1.00104 VPS35L - VPS35 endosomal protein-sorting factor-like - Pongo abelii (Sumatran orangutan) - VPS35L gene Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability. Indicus|evm.model.CM009515.1.302 A5D7J3 KNOP1_BOVIN 99.336 0.995585 1.00221 KNOP1 - Lysine-rich nucleolar protein 1 - Bos taurus (Bovine) - KNOP1 gene Indicus|evm.model.CM009515.1.303 Q8N0W5 IQCK_HUMAN 74.825 0.993031 1 IQCK - IQ domain-containing protein K - Homo sapiens (Human) - IQCK gene Indicus|evm.model.CM009515.1.304 Q9NZH0 GPC5B_HUMAN 88.354 0.994845 0.962779 GPRC5B - G-protein coupled receptor family C group 5 member B precursor - Homo sapiens (Human) - GPRC5B gene Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Indicus|evm.model.CM009515.1.305 Q6DWJ6 GP139_HUMAN 96.835 0.755396 1.1813 GPR139 - Probable G-protein coupled receptor 139 - Homo sapiens (Human) - GPR139 gene Orphan receptor. Seems to act through a G(q/11)-mediated pathway. Indicus|evm.model.CM009515.1.306 P55259 GP2_HUMAN 76.623 0.996262 0.996276 GP2 - Pancreatic secretory granule membrane major glycoprotein GP2 precursor - Homo sapiens (Human) - GP2 gene Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participates to the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response. Indicus|evm.model.CM009515.1.307 P48733 UROM_BOVIN 99.844 0.996894 1.00156 UMOD - Uromodulin precursor - Bos taurus (Bovine) - UMOD gene Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. Indicus|evm.model.CM009515.1.308 Q8N807 PDILT_HUMAN 76.250 0.950342 1 PDILT - Protein disulfide-isomerase-like protein of the testis precursor - Homo sapiens (Human) - PDILT gene Probable redox-inactive chaperone involved in spermatogenesis. Indicus|evm.model.CM009515.1.309 Q6NUN0 ACSM5_HUMAN 90.295 0.974619 1.02073 ACSM5 - Acyl-coenzyme A synthetase ACSM5, mitochondrial precursor - Homo sapiens (Human) - ACSM5 gene Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Indicus|evm.model.CM009515.1.310 Q68CK6 ACS2B_HUMAN 77.098 0.987296 0.954939 ACSM2B - Acyl-coenzyme A synthetase ACSM2B, mitochondrial precursor - Homo sapiens (Human) - ACSM2B gene Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065, PubMed:12616642). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10434065, PubMed:12616642). Indicus|evm.model.CM009515.1.311 Q9BEA2 ACSM1_BOVIN 99.827 0.635061 1.57192 ACSM1 - Acyl-coenzyme A synthetase ACSM1, mitochondrial precursor - Bos taurus (Bovine) - ACSM1 gene Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11382754, PubMed:10561077). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10561077, PubMed:11382754). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (PubMed:11382754). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (PubMed:11382754). Indicus|evm.model.CM009515.1.313 P0C7M7 ACSM4_HUMAN 91.367 0.991071 0.965517 ACSM4 - Acyl-coenzyme A synthetase ACSM4, mitochondrial precursor - Homo sapiens (Human) - ACSM4 gene Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids (By similarity). Indicus|evm.model.CM009515.1.314 Q24K03 THUM1_BOVIN 100.000 0.994413 1.0028 THUMPD1 - THUMP domain-containing protein 1 - Bos taurus (Bovine) - THUMPD1 gene Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation. Indicus|evm.model.CM009515.1.315 Q5REV5 ACSM3_PONAB 89.483 0.996558 0.991468 ACSM3 - Acyl-coenzyme A synthetase ACSM3, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - ACSM3 gene Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (By similarity). Indicus|evm.model.CM009515.1.316 A8K979 ERI2_HUMAN 78.468 0.997101 0.998553 ERI2 - ERI1 exoribonuclease 2 - Homo sapiens (Human) - ERI2 gene 3'-5'-exoribonuclease activity, DNA catabolic process, exonucleolytic, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Indicus|evm.model.CM009515.1.317 Q2T9U5 REXO5_BOVIN 99.872 0.997449 1.00128 REXO5 - RNA exonuclease 5 - Bos taurus (Bovine) - REXO5 gene nucleus, exonuclease activity Indicus|evm.model.CM009515.1.318 Q5E9V1 DCNL3_BOVIN 100.000 0.993443 1.00329 DCUN1D3 - DCN1-like protein 3 - Bos taurus (Bovine) - DCUN1D3 gene Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation. Indicus|evm.model.CM009515.1.319 O43615 TIM44_HUMAN 77.119 0.97479 0.263274 TIMM44 - Mitochondrial import inner membrane translocase subunit TIM44 precursor - Homo sapiens (Human) - TIMM44 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). Indicus|evm.model.CM009515.1.320 O43615 TIM44_HUMAN 59.896 0.987261 0.347345 TIMM44 - Mitochondrial import inner membrane translocase subunit TIM44 precursor - Homo sapiens (Human) - TIMM44 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). Indicus|evm.model.CM009515.1.321 O43325 LYRM1_HUMAN 92.623 0.98374 1.0082 LYRM1 - LYR motif-containing protein 1 - Homo sapiens (Human) - LYRM1 gene May promote cell proliferation and inhibition of apoptosis of preadipocytes. Indicus|evm.model.CM009515.1.322 Q8TD57 DYH3_HUMAN 88.796 0.999261 0.657434 DNAH3 - Dynein axonemal heavy chain 3 - Homo sapiens (Human) - DNAH3 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Indicus|evm.model.CM009515.1.323 Q96B96 LDAF1_HUMAN 72.671 0.987654 1.00621 TMEM159 - Lipid droplet assembly factor 1 - Homo sapiens (Human) - TMEM159 gene Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis (PubMed:31708432). In association with BSCL2/seipin, defines the sites of LD formation in the endoplasmic reticulum (PubMed:31708432). Indicus|evm.model.CM009515.1.324 Q9BH10 ZP2_BOVIN 99.424 0.919205 1.05891 ZP2 - Zona pellucida sperm-binding protein 2 precursor - Bos taurus (Bovine) - ZP2 gene Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Indicus|evm.model.CM009515.1.325 Q8N8V4 ANS4B_HUMAN 86.571 0.995157 0.990408 ANKS4B - Ankyrin repeat and SAM domain-containing protein 4B - Homo sapiens (Human) - ANKS4B gene As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed:26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity). Indicus|evm.model.CM009515.1.326 Q2KHX6 CRYM_BOVIN 100.000 0.993651 1.00318 CRYM - Ketimine reductase mu-crystallin - Bos taurus (Bovine) - CRYM gene Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity). Indicus|evm.model.CM009515.1.328 Q8R420 ABCA3_MOUSE 47.780 0.995204 0.978873 Abca3 - Phospholipid-transporting ATPase ABCA3 - Mus musculus (Mouse) - Abca3 gene Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:17577581, PubMed:17540762, PubMed:17267394, PubMed:17142808, PubMed:20190032, PubMed:28034695). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:17142808). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (By similarity). Indicus|evm.model.CM009515.1.329 P23004 QCR2_BOVIN 99.779 0.995595 1.00221 UQCRC2 - Cytochrome b-c1 complex subunit 2, mitochondrial precursor - Bos taurus (Bovine) - UQCRC2 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (PubMed:9694818, PubMed:11073949). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Indicus|evm.model.CM009515.1.330 Q32KW7 PDZD9_BOVIN 100.000 0.992424 1.0038 PDZD9 - PDZ domain-containing protein 9 - Bos taurus (Bovine) - PDZD9 gene Indicus|evm.model.CM009515.1.331 Q8C784 MOSMO_MOUSE 100.000 0.988095 1.00599 Mosmo - Modulator of smoothened protein - Mus musculus (Mouse) - Mosmo gene Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane (PubMed:29290584). Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation (PubMed:29290584). Indicus|evm.model.CM009515.1.332 A6NCI4 VWA3A_HUMAN 78.889 0.99744 0.989865 VWA3A - von Willebrand factor A domain-containing protein 3A precursor - Homo sapiens (Human) - VWA3A gene Indicus|evm.model.CM009515.1.333 A6NKP2 D42E2_HUMAN 89.610 0.843407 0.862559 SDR42E2 - Putative short-chain dehydrogenase/reductase family 42E member 2 - Homo sapiens (Human) - SDR42E2 gene oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Indicus|evm.model.CM009515.1.334 O00418 EF2K_HUMAN 90.483 0.997238 0.998621 EEF2K - Eukaryotic elongation factor 2 kinase - Homo sapiens (Human) - EEF2K gene Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. Indicus|evm.model.CM009515.1.335 Q9NVU0 RPC5_HUMAN 90.858 0.997122 0.981638 POLR3E - DNA-directed RNA polymerase III subunit RPC5 - Homo sapiens (Human) - POLR3E gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Indicus|evm.model.CM009515.1.336 Q01850 CDR2_HUMAN 90.562 0.995516 0.982379 CDR2 - Cerebellar degeneration-related protein 2 - Homo sapiens (Human) - CDR2 gene Indicus|evm.model.CM009515.1.338 Q0VCJ8 METL9_BOVIN 100.000 0.99373 1.00314 METTL9 - Protein-L-histidine N-pros-methyltransferase precursor - Bos taurus (Bovine) - METTL9 gene Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins. Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins. Constitutes the main methyltransferase for the 1-methylhistidine modification in cell. Indicus|evm.model.CM009515.1.339 Q7RTW8 OTOAN_HUMAN 82.511 0.998185 0.955768 OTOA - Otoancorin precursor - Homo sapiens (Human) - OTOA gene May act as an adhesion molecule. Indicus|evm.model.CM009515.1.340 Q5RE65 CWC15_PONAB 62.585 0.880952 0.550218 CWC15 - Spliceosome-associated protein CWC15 homolog - Pongo abelii (Sumatran orangutan) - CWC15 gene Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Indicus|evm.model.CM009515.1.341 Q9Y278 HS3S2_HUMAN 93.902 0.840206 0.52861 HS3ST2 - Heparan sulfate glucosamine 3-O-sulfotransferase 2 - Homo sapiens (Human) - HS3ST2 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Indicus|evm.model.CM009515.1.342 Q9Y278 HS3S2_HUMAN 98.522 0.990196 0.555858 HS3ST2 - Heparan sulfate glucosamine 3-O-sulfotransferase 2 - Homo sapiens (Human) - HS3ST2 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Indicus|evm.model.CM009515.1.343 Q70CQ4 UBP31_HUMAN 92.639 0.981286 0.909024 USP31 - Ubiquitin carboxyl-terminal hydrolase 31 - Homo sapiens (Human) - USP31 gene May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Indicus|evm.model.CM009515.1.344 F1MJW3 SCNNG_BOVIN 100.000 0.911142 1.08742 SCNN1G - Amiloride-sensitive sodium channel subunit gamma - Bos taurus (Bovine) - SCNN1G gene Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Indicus|evm.model.CM009515.1.346 A5D7U4 SCNNB_BOVIN 99.844 0.996885 1.00156 SCNN1B - Amiloride-sensitive sodium channel subunit beta - Bos taurus (Bovine) - SCNN1B gene Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Indicus|evm.model.CM009515.1.347 A2VDR8 COG7_BOVIN 100.000 0.997406 1.0013 COG7 - Conserved oligomeric Golgi complex subunit 7 - Bos taurus (Bovine) - COG7 gene Required for normal Golgi function. Indicus|evm.model.CM009515.1.348 Q9UJY4 GGA2_HUMAN 91.096 0.994872 0.954323 GGA2 - ADP-ribosylation factor-binding protein GGA2 - Homo sapiens (Human) - GGA2 gene Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). Indicus|evm.model.CM009515.1.349 Q5JPH6 SYEM_HUMAN 87.795 0.960227 1.00956 EARS2 - Probable glutamate--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - EARS2 gene Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). Indicus|evm.model.CM009515.1.350 O14562 UBFD1_HUMAN 85.761 0.99262 0.877023 UBFD1 - Ubiquitin domain-containing protein UBFD1 - Homo sapiens (Human) - UBFD1 gene May play a role as NF-kappa-B regulator. Indicus|evm.model.CM009515.1.351 P52505 ACPM_BOVIN 98.718 0.987261 1.00641 NDUFAB1 - Acyl carrier protein, mitochondrial precursor - Bos taurus (Bovine) - NDUFAB1 gene Carrier of the growing fatty acid chain in fatty acid biosynthesis (PubMed:1907568). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:1907568, PubMed:10852722, PubMed:18721790). Indicus|evm.model.CM009515.1.352 Q86YC2 PALB2_HUMAN 67.337 0.990803 1.00843 PALB2 - Partner and localizer of BRCA2 - Homo sapiens (Human) - PALB2 gene Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19423707, PubMed:19369211, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). Indicus|evm.model.CM009515.1.353 Q9BTE1 DCTN5_HUMAN 99.451 0.989071 1.00549 DCTN5 - Dynactin subunit 5 - Homo sapiens (Human) - DCTN5 gene centrosome, cytosol, nuclear membrane, nucleoplasm, antigen processing and presentation of exogenous peptide antigen via MHC class II, endoplasmic reticulum to Golgi vesicle-mediated transport Indicus|evm.model.CM009515.1.354 Q2TA25 PLK1_BOVIN 100.000 0.996683 1.00166 PLK1 - Serine/threonine-protein kinase PLK1 - Bos taurus (Bovine) - PLK1 gene Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis.Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning. Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Phosphorylates CEP68 and is required for its degradation. Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope. Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock. Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression. Regulates mitotic progression by phosphorylating RIOK2 (By similarity). Indicus|evm.model.CM009515.1.355 Q76MJ5 ERN2_HUMAN 85.437 0.99676 1 ERN2 - Serine/threonine-protein kinase/endoribonuclease IRE2 precursor - Homo sapiens (Human) - ERN2 gene Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. Indicus|evm.model.CM009515.1.356 O43745 CHP2_HUMAN 85.204 0.989848 1.0051 CHP2 - Calcineurin B homologous protein 2 - Homo sapiens (Human) - CHP2 gene Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. Indicus|evm.model.CM009515.1.357 P05126 KPCB_BOVIN 96.557 0.988131 1.00447 PRKCB - Protein kinase C beta type - Bos taurus (Bovine) - PRKCB gene Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity). Indicus|evm.model.CM009515.1.358 P68403 KPCB_RAT 100.000 0.415254 0.175857 Prkcb - Protein kinase C beta type - Rattus norvegicus (Rat) - Prkcb gene Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Indicus|evm.model.CM009515.1.359 Q0VD05 CCG3_BOVIN 95.785 0.938628 0.879365 CACNG3 - Voltage-dependent calcium channel gamma-3 subunit - Bos taurus (Bovine) - CACNG3 gene Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Indicus|evm.model.CM009515.1.360 Q7Z6E9 RBBP6_HUMAN 92.027 0.669077 1.00335 RBBP6 - E3 ubiquitin-protein ligase RBBP6 - Homo sapiens (Human) - RBBP6 gene E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Indicus|evm.model.CM009515.1.362 Q8NDV7 TNR6A_HUMAN 93.431 0.969405 0.899592 TNRC6A - Trinucleotide repeat-containing gene 6A protein - Homo sapiens (Human) - TNRC6A gene Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. Indicus|evm.model.CM009515.1.363 Q3ZC26 SC5AB_BOVIN 100.000 0.997037 1.00148 SLC5A11 - Sodium/myo-inositol cotransporter 2 - Bos taurus (Bovine) - SLC5A11 gene Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. Indicus|evm.model.CM009515.1.364 Q68EM7 RHG17_HUMAN 89.965 0.977117 0.992054 ARHGAP17 - Rho GTPase-activating protein 17 - Homo sapiens (Human) - ARHGAP17 gene Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. Indicus|evm.model.CM009515.1.366 Q15643 TRIPB_HUMAN 49.289 0.967568 0.0934816 TRIP11 - Thyroid receptor-interacting protein 11 - Homo sapiens (Human) - TRIP11 gene Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Indicus|evm.model.CM009515.1.367 Q15643 TRIPB_HUMAN 45.366 0.988571 0.0884285 TRIP11 - Thyroid receptor-interacting protein 11 - Homo sapiens (Human) - TRIP11 gene Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Indicus|evm.model.CM009515.1.368 Q3T0H0 LCMT1_BOVIN 99.088 0.502297 1.96687 LCMT1 - Leucine carboxyl methyltransferase 1 - Bos taurus (Bovine) - LCMT1 gene Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Indicus|evm.model.CM009515.1.369 Q63HK3 ZKSC2_HUMAN 85.759 0.997938 1.0031 ZKSCAN2 - Zinc finger protein with KRAB and SCAN domains 2 - Homo sapiens (Human) - ZKSCAN2 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.370 Q9Y661 HS3S4_HUMAN 90.722 0.768595 0.265351 HS3ST4 - Heparan sulfate glucosamine 3-O-sulfotransferase 4 - Homo sapiens (Human) - HS3ST4 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Indicus|evm.model.CM009515.1.371 Q9Y661 HS3S4_HUMAN 99.043 0.990476 0.460526 HS3ST4 - Heparan sulfate glucosamine 3-O-sulfotransferase 4 - Homo sapiens (Human) - HS3ST4 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Indicus|evm.model.CM009515.1.373 Q7Z2V1 TNT_HUMAN 48.438 0.651282 0.898618 C16orf82 - Protein TNT - Homo sapiens (Human) - C16orf82 gene Indicus|evm.model.CM009515.1.375 Q3T0X7 NSE1_BOVIN 98.222 0.986784 0.853383 NSMCE1 - Non-structural maintenance of chromosomes element 1 homolog - Bos taurus (Bovine) - NSMCE1 gene RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. Indicus|evm.model.CM009515.1.377 Q1JP61 KDM8_BOVIN 98.039 0.99511 1.00739 KDM8 - Bifunctional peptidase and arginyl-hydroxylase JMJD5 - Bos taurus (Bovine) - KDM8 gene Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage. Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established. Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation. Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition. Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation. Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (By similarity). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a catalytically-independent manner (By similarity). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (By similarity). Indicus|evm.model.CM009515.1.378 Q3T0X7 NSE1_BOVIN 92.308 0.513514 0.278195 NSMCE1 - Non-structural maintenance of chromosomes element 1 homolog - Bos taurus (Bovine) - NSMCE1 gene RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. Indicus|evm.model.CM009515.1.379 Q863Z5 IL4RA_PIG 72.850 0.953069 1.0012 IL4R - Interleukin-4 receptor subunit alpha precursor - Sus scrofa (Pig) - IL4R gene Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). Indicus|evm.model.CM009515.1.380 Q9HBE5 IL21R_HUMAN 62.821 0.996241 0.988848 IL21R - Interleukin-21 receptor precursor - Homo sapiens (Human) - IL21R gene This is a receptor for interleukin-21. Indicus|evm.model.CM009515.1.381 Q12789 TF3C1_HUMAN 79.405 0.999046 0.99431 GTF3C1 - General transcription factor 3C polypeptide 1 - Homo sapiens (Human) - GTF3C1 gene Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. Indicus|evm.model.CM009515.1.382 O60303 KATIP_HUMAN 75.904 0.996283 0.997528 KATNIP - Katanin-interacting protein - Homo sapiens (Human) - KATNIP gene May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. Indicus|evm.model.CM009515.1.383 D3ZK93 GSG1L_RAT 95.161 0.576324 0.996894 Gsg1l - Germ cell-specific gene 1-like protein - Rattus norvegicus (Rat) - Gsg1l gene As a component of the inner core of AMPAR complexes, modifies AMPA receptor (AMPAR) gating. Indicus|evm.model.CM009515.1.384 Q96QU8 XPO6_HUMAN 98.133 0.998224 1.00089 XPO6 - Exportin-6 - Homo sapiens (Human) - XPO6 gene Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. Indicus|evm.model.CM009515.1.386 Q52WX2 SBK1_HUMAN 98.712 0.935484 0.584906 SBK1 - Serine/threonine-protein kinase SBK1 - Homo sapiens (Human) - SBK1 gene May be involved in signal-transduction pathways related to the control of brain development. Indicus|evm.model.CM009515.1.387 Q3SZR9 TSN3_BOVIN 91.241 0.978417 0.549407 TSPAN3 - Tetraspanin-3 - Bos taurus (Bovine) - TSPAN3 gene Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. Indicus|evm.model.CM009515.1.388 O43561 LAT_HUMAN 65.417 0.901961 0.973282 LAT - Linker for activation of T-cells family member 1 - Homo sapiens (Human) - LAT gene Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. Indicus|evm.model.CM009515.1.389 Q08DX7 SPNS1_BOVIN 99.811 0.996219 1.00189 SPNS1 - Protein spinster homolog 1 - Bos taurus (Bovine) - SPNS1 gene Sphingolipid transporter. May be involved in necrotic or autophagic cell death (By similarity). Indicus|evm.model.CM009515.1.390 Q8NCF5 NF2IP_HUMAN 77.403 0.916268 0.997613 NFATC2IP - NFATC2-interacting protein - Homo sapiens (Human) - NFATC2IP gene In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). Indicus|evm.model.CM009515.1.391 P15391 CD19_HUMAN 63.345 0.991135 1.01439 CD19 - B-lymphocyte antigen CD19 precursor - Homo sapiens (Human) - CD19 gene Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:9382888, PubMed:9317126, PubMed:12387743, PubMed:16672701). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:2463100, PubMed:1373518). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:9317126, PubMed:12387743, PubMed:16672701). Indicus|evm.model.CM009515.1.392 A4FUG8 RABE2_BOVIN 99.658 0.996587 1.00171 RABEP2 - Rab GTPase-binding effector protein 2 - Bos taurus (Bovine) - RABEP2 gene Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis. Indicus|evm.model.CM009515.1.393 Q0VCY0 AT2A1_BOVIN 98.387 0.978916 1.00302 ATP2A1 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 - Bos taurus (Bovine) - ATP2A1 gene Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:22387132). Contributes to calcium sequestration involved in muscular excitation/contraction. Indicus|evm.model.CM009515.1.394 Q9NRF2 SH2B1_HUMAN 94.462 0.938897 0.887566 SH2B1 - SH2B adapter protein 1 - Homo sapiens (Human) - SH2B1 gene Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity). Indicus|evm.model.CM009515.1.395 P49410 EFTU_BOVIN 100.000 0.995585 1.00221 TUFM - Elongation factor Tu, mitochondrial precursor - Bos taurus (Bovine) - TUFM gene Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. Indicus|evm.model.CM009515.1.396 Q8WWM7 ATX2L_HUMAN 96.384 0.984991 0.991628 ATXN2L - Ataxin-2-like protein - Homo sapiens (Human) - ATXN2L gene Involved in the regulation of stress granule and P-body formation. Indicus|evm.model.CM009515.1.397 Q3SYW6 EIF3C_BOVIN 100.000 0.997809 1.0011 EIF3C - Eukaryotic translation initiation factor 3 subunit C - Bos taurus (Bovine) - EIF3C gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Indicus|evm.model.CM009515.1.398 Q60HH0 CLN3_MACFA 88.356 0.995444 1.00228 CLN3 - Battenin precursor - Macaca fascicularis (Crab-eating macaque) - CLN3 gene Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission. Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (By similarity). Moreover regulates CTSD activity in response to osmotic stress (By similarity). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis. At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex. Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory. Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process. Participates also in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (By similarity). Indicus|evm.model.CM009515.1.399 Q0VD83 APOBR_HUMAN 62.585 0.279138 0.93072 APOBR - Apolipoprotein B receptor - Homo sapiens (Human) - APOBR gene Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. Indicus|evm.model.CM009515.1.400 Q5S1V9 IL27A_PIG 84.519 0.991597 0.995816 IL27 - Interleukin-27 subunit alpha precursor - Sus scrofa (Pig) - IL27 gene Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II (By similarity). Indicus|evm.model.CM009515.1.401 O60356 NUPR1_HUMAN 82.716 0.963855 1.0122 NUPR1 - Nuclear protein 1 - Homo sapiens (Human) - NUPR1 gene Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:16478804, PubMed:19650074, PubMed:16300740, PubMed:19723804, PubMed:11056169, PubMed:22858377, PubMed:11940591, PubMed:18690848, PubMed:22565310, PubMed:20181828, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). Indicus|evm.model.CM009515.1.402 Q96ES7 SGF29_HUMAN 100.000 0.960526 0.259386 SGF29 - SAGA-associated factor 29 - Homo sapiens (Human) - SGF29 gene Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Indicus|evm.model.CM009515.1.403 Q96ES7 SGF29_HUMAN 89.844 0.92029 0.47099 SGF29 - SAGA-associated factor 29 - Homo sapiens (Human) - SGF29 gene Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Indicus|evm.model.CM009515.1.404 P0C606 SGF29_RAT 100.000 0.866667 0.358362 Sgf29 - SAGA-associated factor 29 - Rattus norvegicus (Rat) - Sgf29 gene Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:17334388). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (By similarity). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (By similarity). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (By similarity). May be involved in MYC-mediated oncogenic transformation (PubMed:17334388). Indicus|evm.model.CM009515.1.405 P50227 ST1A1_BOVIN 98.644 0.993243 1.00339 SULT1A1 - Sulfotransferase 1A1 - Bos taurus (Bovine) - SULT1A1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (By similarity). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil. Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). Indicus|evm.model.CM009515.1.406 Q32PI0 SLX1_BOVIN 100.000 0.992537 1.00375 SLX1A - Structure-specific endonuclease subunit SLX1 - Bos taurus (Bovine) - SLX1A gene Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Indicus|evm.model.CM009515.1.407 Q9H3K6 BOLA2_HUMAN 91.860 0.977011 1.01163 BOLA2 - BolA-like protein 2 - Homo sapiens (Human) - BOLA2 gene Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415). Indicus|evm.model.CM009515.1.408 Q92176 COR1A_BOVIN 99.566 0.936864 1.06508 CORO1A - Coronin-1A - Bos taurus (Bovine) - CORO1A gene May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected macrophages, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes (By similarity). Indicus|evm.model.CM009515.1.409 P27361 MK03_HUMAN 98.754 0.924855 0.912929 MAPK3 - Mitogen-activated protein kinase 3 - Homo sapiens (Human) - MAPK3 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Indicus|evm.model.CM009515.1.410 Q7L5L3 GDPD3_HUMAN 82.353 0.956113 1.00314 GDPD3 - Lysophospholipase D GDPD3 - Homo sapiens (Human) - GDPD3 gene Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. Indicus|evm.model.CM009515.1.411 P61237 YPEL3_MOUSE 100.000 0.983333 1.0084 Ypel3 - Protein yippee-like 3 - Mus musculus (Mouse) - Ypel3 gene Involved in proliferation and apoptosis in myeloid precursor cells. Indicus|evm.model.CM009515.1.412 E1BEA8 TBX6_BOVIN 94.955 0.751678 0.978118 TBX6 - T-box transcription factor TBX6 - Bos taurus (Bovine) - TBX6 gene T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to also play an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). Indicus|evm.model.CM009515.1.413 Q5R6K8 PP4C_PONAB 100.000 0.993506 1.00326 PPP4C - Serine/threonine-protein phosphatase 4 catalytic subunit - Pongo abelii (Sumatran orangutan) - PPP4C gene Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin (By similarity). Indicus|evm.model.CM009515.1.414 P04075 ALDOA_HUMAN 97.802 0.994521 1.00275 ALDOA - Fructose-bisphosphate aldolase A - Homo sapiens (Human) - ALDOA gene Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Indicus|evm.model.CM009515.1.416 Q14183 DOC2A_HUMAN 96.010 0.683761 1.4625 DOC2A - Double C2-like domain-containing protein alpha - Homo sapiens (Human) - DOC2A gene Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. Indicus|evm.model.CM009515.1.417 Q29RS4 IN80E_BOVIN 94.262 0.991342 0.946721 INO80E - INO80 complex subunit E - Bos taurus (Bovine) - INO80E gene Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Indicus|evm.model.CM009515.1.418 Q9BW71 HIRP3_HUMAN 66.780 0.99651 1.03058 HIRIP3 - HIRA-interacting protein 3 - Homo sapiens (Human) - HIRIP3 gene May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. Indicus|evm.model.CM009515.1.419 Q5R4F3 TAOK3_PONAB 72.222 0.583062 0.341871 TAOK3 - Serine/threonine-protein kinase TAO3 - Pongo abelii (Sumatran orangutan) - TAOK3 gene Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity). Indicus|evm.model.CM009515.1.420 Q9UL54 TAOK2_HUMAN 92.880 0.998355 0.984615 TAOK2 - Serine/threonine-protein kinase TAO2 - Homo sapiens (Human) - TAOK2 gene Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. Indicus|evm.model.CM009515.1.421 Q1JQE1 TM219_BOVIN 100.000 0.804054 1.23849 TMEM219 - Insulin-like growth factor-binding protein 3 receptor precursor - Bos taurus (Bovine) - TMEM219 gene Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding. Indicus|evm.model.CM009515.1.422 Q2T9W0 BACD1_BOVIN 99.696 0.993939 1.00304 KCTD13 - BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 - Bos taurus (Bovine) - KCTD13 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission. Indicus|evm.model.CM009515.1.423 A1L515 ASPH1_BOVIN 100.000 0.99187 0.6703 ASPHD1 - Aspartate beta-hydroxylase domain-containing protein 1 - Bos taurus (Bovine) - ASPHD1 gene Indicus|evm.model.CM009515.1.424 Q29RN8 SE6L2_BOVIN 98.592 0.997835 1.01538 SEZ6L2 - Seizure 6-like protein 2 precursor - Bos taurus (Bovine) - SEZ6L2 gene May contribute to specialized endoplasmic reticulum functions in neurons. Indicus|evm.model.CM009515.1.425 P0DO93 ENOL_RAT 68.478 0.735537 1.35955 T-enol - Putative protein T-ENOL - Rattus norvegicus (Rat) - T-enol gene Indicus|evm.model.CM009515.1.426 P70500 CDIPT_RAT 96.244 0.990654 1.00469 Cdipt - CDP-diacylglycerol--inositol 3-phosphatidyltransferase - Rattus norvegicus (Rat) - Cdipt gene Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. Indicus|evm.model.CM009515.1.427 Q3SYU9 MVP_BOVIN 99.888 0.997755 1.00112 MVP - Major vault protein - Bos taurus (Bovine) - MVP gene Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity). Indicus|evm.model.CM009515.1.428 Q1LZ80 PAGR1_BOVIN 100.000 0.992126 1.00395 PAGR1 - PAXIP1-associated glutamate-rich protein 1 - Bos taurus (Bovine) - PAGR1 gene Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent. Indicus|evm.model.CM009515.1.429 Q5RAC1 PRRT2_PONAB 80.347 0.994236 1.02059 PRRT2 - Proline-rich transmembrane protein 2 - Pongo abelii (Sumatran orangutan) - PRRT2 gene As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. Indicus|evm.model.CM009515.1.430 A6QPL4 KIF22_BOVIN 100.000 0.836788 1.16616 KIF22 - Kinesin-like protein KIF22 - Bos taurus (Bovine) - KIF22 gene Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Indicus|evm.model.CM009515.1.431 O60844 ZG16_HUMAN 80.240 0.988095 1.00599 ZG16 - Zymogen granule membrane protein 16 precursor - Homo sapiens (Human) - ZG16 gene May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN. Indicus|evm.model.CM009515.1.432 Q6UWD8 CP054_HUMAN 75.893 0.951754 1.01786 C16orf54 - Transmembrane protein C16orf54 - Homo sapiens (Human) - C16orf54 gene Indicus|evm.model.CM009515.1.433 Q3T063 NADC_BOVIN 100.000 0.189853 2.04348 QPRT - Nicotinate-nucleotide pyrophosphorylase [carboxylating] - Bos taurus (Bovine) - QPRT gene Involved in the catabolism of quinolinic acid (QA). Indicus|evm.model.CM009515.1.434 Q9CWK3 CD2B2_MOUSE 88.338 0.994152 1 Cd2bp2 - CD2 antigen cytoplasmic tail-binding protein 2 - Mus musculus (Mouse) - Cd2bp2 gene Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. Indicus|evm.model.CM009515.1.436 Q4KMP7 TB10B_HUMAN 92.722 0.98984 0.852723 TBC1D10B - TBC1 domain family member 10B - Homo sapiens (Human) - TBC1D10B gene Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A. Indicus|evm.model.CM009515.1.437 Q0P571 MLRS_BOVIN 100.000 0.988304 1.00588 MYLPF - Myosin regulatory light chain 2, skeletal muscle isoform - Bos taurus (Bovine) - MYLPF gene Indicus|evm.model.CM009515.1.438 A5PJU9 SEPT1_BOVIN 100.000 0.994565 1.00272 SEPTIN1 - Septin-1 - Bos taurus (Bovine) - SEPTIN1 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Indicus|evm.model.CM009515.1.439 Q96MX3 ZNF48_HUMAN 90.909 0.99681 1.01456 ZNF48 - Zinc finger protein 48 - Homo sapiens (Human) - ZNF48 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.440 Q7L3S4 ZN771_HUMAN 91.611 0.936306 0.990536 ZNF771 - Zinc finger protein 771 - Homo sapiens (Human) - ZNF771 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.441 Q32KY6 DCTP1_BOVIN 98.817 0.988235 1.00592 DCTPP1 - dCTP pyrophosphatase 1 - Bos taurus (Bovine) - DCTPP1 gene Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. Indicus|evm.model.CM009515.1.442 P97364 SPS2_MOUSE 96.785 0.936556 0.732301 Sephs2 - Selenide, water dikinase 2 - Mus musculus (Mouse) - Sephs2 gene Synthesizes selenophosphate from selenide and ATP. Indicus|evm.model.CM009515.1.443 P61625 ITAL_BOVIN 99.657 0.998279 0.997425 ITGAL - Integrin alpha-L precursor - Bos taurus (Bovine) - ITGAL gene Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. Indicus|evm.model.CM009515.1.444 Q9H5H4 ZN768_HUMAN 90.196 0.996441 1.04074 ZNF768 - Zinc finger protein 768 - Homo sapiens (Human) - ZNF768 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.445 Q96H86 ZN764_HUMAN 77.136 0.961165 1.0098 ZNF764 - Zinc finger protein 764 - Homo sapiens (Human) - ZNF764 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.446 P0C7X2 ZN688_HUMAN 84.411 0.945848 1.00362 ZNF688 - Zinc finger protein 688 - Homo sapiens (Human) - ZNF688 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.447 Q96CS4 ZN689_HUMAN 92.814 0.994012 1.002 ZNF689 - Zinc finger protein 689 - Homo sapiens (Human) - ZNF689 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.448 Q9HAH7 FBRS_HUMAN 97.835 0.305703 3.27826 FBRS - Probable fibrosin-1 - Homo sapiens (Human) - FBRS gene Indicus|evm.model.CM009515.1.449 Q6ZRS2 SRCAP_HUMAN 89.698 0.928697 1.05944 SRCAP - Helicase SRCAP - Homo sapiens (Human) - SRCAP gene Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Indicus|evm.model.CM009515.1.450 Q2KJ16 PHKG2_BOVIN 100.000 0.995086 1.00246 PHKG2 - Phosphorylase b kinase gamma catalytic chain, liver/testis isoform - Bos taurus (Bovine) - PHKG2 gene Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity). Indicus|evm.model.CM009515.1.451 A1A4V9 CC189_HUMAN 76.807 0.993994 1.00604 CCDC189 - Coiled-coil domain-containing protein 189 - Homo sapiens (Human) - CCDC189 gene Indicus|evm.model.CM009515.1.452 Q5RAU7 BRE1B_PONAB 95.904 0.998004 1.001 RNF40 - E3 ubiquitin-protein ligase BRE1B - Pongo abelii (Sumatran orangutan) - RNF40 gene Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Indicus|evm.model.CM009515.1.454 Q9UEG4 ZN629_HUMAN 91.484 0.997699 1 ZNF629 - Zinc finger protein 629 - Homo sapiens (Human) - ZNF629 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.455 Q8WUZ0 BCL7C_HUMAN 73.438 0.984375 0.589862 BCL7C - B-cell CLL/lymphoma 7 protein family member C - Homo sapiens (Human) - BCL7C gene May play an anti-apoptotic role. Indicus|evm.model.CM009515.1.456 Q16619 CTF1_HUMAN 81.683 0.990148 1.00995 CTF1 - Cardiotrophin-1 - Homo sapiens (Human) - CTF1 gene Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. Indicus|evm.model.CM009515.1.457 P83714 CTF2_MOUSE 57.542 0.809091 1.07843 Ctf2 - Cardiotrophin-2 precursor - Mus musculus (Mouse) - Ctf2 gene Increases the platelet count associated with splenomegaly. May have an important role in neuronal precursor development and maturation. Indicus|evm.model.CM009515.1.458 P59997 KDM2A_MOUSE 77.778 0.171233 0.125754 Kdm2a - Lysine-specific demethylase 2A - Mus musculus (Mouse) - Kdm2a gene Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis (By similarity). Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (By similarity). Indicus|evm.model.CM009515.1.459 P83714 CTF2_MOUSE 54.144 0.544025 1.55882 Ctf2 - Cardiotrophin-2 precursor - Mus musculus (Mouse) - Ctf2 gene Increases the platelet count associated with splenomegaly. May have an important role in neuronal precursor development and maturation. Indicus|evm.model.CM009515.1.460 Q6PCT2 FXL19_HUMAN 99.277 0.936314 1.0634 FBXL19 - F-box/LRR-repeat protein 19 - Homo sapiens (Human) - FBXL19 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:29276034). Indicus|evm.model.CM009515.1.461 Q6AXR8 ORAI3_RAT 89.420 0.993151 1.0069 Orai3 - Protein orai-3 - Rattus norvegicus (Rat) - Orai3 gene Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. Indicus|evm.model.CM009515.1.462 O15047 SET1A_HUMAN 92.749 0.341421 1.01406 SETD1A - Histone-lysine N-methyltransferase SETD1A - Homo sapiens (Human) - SETD1A gene Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression (PubMed:12670868). May play a role in synaptic function and the development of neurons (PubMed:31197650). Indicus|evm.model.CM009515.1.463 Q9H2F3 3BHS7_HUMAN 90.217 0.99458 1 HSD3B7 - 3 beta-hydroxysteroid dehydrogenase type 7 - Homo sapiens (Human) - HSD3B7 gene The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. Indicus|evm.model.CM009515.1.464 P61268 STX1B_SHEEP 100.000 0.99308 1.00347 STX1B - Syntaxin-1B - Ovis aries (Sheep) - STX1B gene Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). Indicus|evm.model.CM009515.1.465 Q3SWZ3 STX4_BOVIN 99.663 0.993289 1.00337 STX4 - Syntaxin-4 - Bos taurus (Bovine) - STX4 gene Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. May also play a role in docking of synaptic vesicles at presynaptic active zones (By similarity). Indicus|evm.model.CM009515.1.467 Q2TA17 ZN668_BOVIN 100.000 0.996774 1.00162 ZNF668 - Zinc finger protein 668 - Bos taurus (Bovine) - ZNF668 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.468 O15015 ZN646_HUMAN 80.076 0.998903 0.995087 ZNF646 - Zinc finger protein 646 - Homo sapiens (Human) - ZNF646 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.469 Q2L4Q9 PRS53_HUMAN 85.099 0.99639 1.00181 PRSS53 - Serine protease 53 precursor - Homo sapiens (Human) - PRSS53 gene In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator. Indicus|evm.model.CM009515.1.470 Q6B4J2 VKOR1_BOVIN 100.000 0.987805 1.00613 VKORC1 - Vitamin K epoxide reductase complex subunit 1 - Bos taurus (Bovine) - VKORC1 gene Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development (By similarity). Indicus|evm.model.CM009515.1.471 Q2KJG8 BCKD_BOVIN 100.000 0.995157 1.00243 BCKDK - [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor - Bos taurus (Bovine) - BCKDK gene Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. Indicus|evm.model.CM009515.1.472 Q9H7Z6 KAT8_HUMAN 99.345 0.995643 1.00218 KAT8 - Histone acetyltransferase KAT8 - Homo sapiens (Human) - KAT8 gene Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126). May influence the function of ATM (PubMed:15923642). As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026). That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026). Can also acetylate TP53/p53 at 'Lys-120'. Indicus|evm.model.CM009515.1.473 Q9ES87 PRSS8_RAT 75.371 0.976744 1.00585 Prss8 - Prostasin precursor - Rattus norvegicus (Rat) - Prss8 gene Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G) (By similarity). Indicus|evm.model.CM009515.1.474 Q5K4E3 POLS2_HUMAN 85.137 0.959538 1.0117 PRSS36 - Polyserase-2 precursor - Homo sapiens (Human) - PRSS36 gene Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1. Indicus|evm.model.CM009515.1.475 Q28009 FUS_BOVIN 100.000 0.996109 1.00195 FUS - RNA-binding protein FUS - Bos taurus (Bovine) - FUS gene DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (By similarity). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). Indicus|evm.model.CM009515.1.476 Q8HXK9 ASC_BOVIN 100.000 0.989796 1.00513 PYCARD - Apoptosis-associated speck-like protein containing a CARD - Bos taurus (Bovine) - PYCARD gene Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing (By similarity). Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA (By similarity). Indicus|evm.model.CM009515.1.477 Q6ZMU5 TRI72_HUMAN 92.600 0.977226 1.01258 TRIM72 - Tripartite motif-containing protein 72 - Homo sapiens (Human) - TRIM72 gene Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). Indicus|evm.model.CM009515.1.478 P11215 ITAM_HUMAN 67.601 0.981018 1.00608 ITGAM - Integrin alpha-M precursor - Homo sapiens (Human) - ITGAM gene Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Indicus|evm.model.CM009515.1.479 Q3V0T4 ITAD_MOUSE 46.809 0.75 0.106164 Itgad - Integrin alpha-D precursor - Mus musculus (Mouse) - Itgad gene Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity). Indicus|evm.model.CM009515.1.480 Q13349 ITAD_HUMAN 74.763 0.993139 1.00431 ITGAD - Integrin alpha-D precursor - Homo sapiens (Human) - ITGAD gene Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. Indicus|evm.model.CM009515.1.481 P07471 CX6A2_BOVIN 100.000 0.979592 1.01031 COX6A2 - Cytochrome c oxidase subunit 6A2, mitochondrial precursor - Bos taurus (Bovine) - COX6A2 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV (By similarity). Indicus|evm.model.CM009515.1.483 Q5EBP3 ARMC5_MOUSE 92.182 0.383459 0.861771 Armc5 - Armadillo repeat-containing protein 5 - Mus musculus (Mouse) - Armc5 gene Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:28169274). Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (By similarity). Indicus|evm.model.CM009515.1.484 Q3MHZ4 TGFI1_BOVIN 100.000 0.995624 1.00219 TGFB1I1 - Transforming growth factor beta-1-induced transcript 1 protein - Bos taurus (Bovine) - TGFB1I1 gene Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. Indicus|evm.model.CM009515.1.485 P31639 SC5A2_HUMAN 91.530 0.997033 1.00298 SLC5A2 - Sodium/glucose cotransporter 2 - Homo sapiens (Human) - SLC5A2 gene Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Indicus|evm.model.CM009515.1.486 Q5R8F6 RUSF1_PONAB 84.061 0.987041 0.989316 Rusf1 - RUS family member 1 - Pongo abelii (Sumatran orangutan) - Rusf1 gene Indicus|evm.model.CM009515.1.487 Q865F8 AHSP_BOVIN 86.420 0.769231 1.13043 AHSP - Alpha-hemoglobin-stabilizing protein - Bos taurus (Bovine) - AHSP gene Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity). Indicus|evm.model.CM009515.1.488 A6QQL3 SEP14_BOVIN 98.843 0.850099 1.17361 SEPTIN14 - Septin-14 - Bos taurus (Bovine) - SEPTIN14 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Indicus|evm.model.CM009515.1.489 Q8N859 ZN713_HUMAN 86.449 0.946548 1.04419 ZNF713 - Zinc finger protein 713 - Homo sapiens (Human) - ZNF713 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.490 P82916 RT17_BOVIN 100.000 0.984733 1.00769 MRPS17 - 28S ribosomal protein S17, mitochondrial - Bos taurus (Bovine) - MRPS17 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit Indicus|evm.model.CM009515.1.491 O75323 NIPS2_HUMAN 95.257 0.868966 1.01399 NIPSNAP2 - Protein NipSnap homolog 2 - Homo sapiens (Human) - NIPSNAP2 gene May act as a positive regulator of L-type calcium channels. Indicus|evm.model.CM009515.1.492 Q2KHU0 SERB_BOVIN 99.556 0.99115 1.00444 PSPH - Phosphoserine phosphatase - Bos taurus (Bovine) - PSPH gene Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine. Indicus|evm.model.CM009515.1.493 Q3MHL7 TCPZ_BOVIN 86.064 0.995992 0.939736 CCT6A - T-complex protein 1 subunit zeta - Bos taurus (Bovine) - CCT6A gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.CM009515.1.494 Q58CP2 SUMF2_BOVIN 100.000 0.993377 1.00332 SUMF2 - Inactive C-alpha-formylglycine-generating enzyme 2 precursor - Bos taurus (Bovine) - SUMF2 gene Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Indicus|evm.model.CM009515.1.495 P07934 PHKG1_MOUSE 94.560 0.992268 1 Phkg1 - Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform - Mus musculus (Mouse) - Phkg1 gene Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). Indicus|evm.model.CM009515.1.496 Q9Y6H1 CHCH2_HUMAN 90.850 0.987013 1.01987 CHCHD2 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 - Homo sapiens (Human) - CHCHD2 gene Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). Indicus|evm.model.CM009515.1.497 Q32PB4 NUPR2_BOVIN 98.980 0.979798 1.0102 NUPR2 - Nuclear protein 2 - Bos taurus (Bovine) - NUPR2 gene Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells. Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation. Plays a role as a negative regulator of the protumoral factor NUPR1. Indicus|evm.model.CM009515.1.498 Q15370 ELOB_HUMAN 84.746 0.983193 1.00847 ELOB - Elongin-B - Homo sapiens (Human) - ELOB gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). Indicus|evm.model.CM009515.1.499 Q8N0U8 VKORL_HUMAN 95.536 0.867188 0.727273 VKORC1L1 - Vitamin K epoxide reductase complex subunit 1-like protein 1 - Homo sapiens (Human) - VKORC1L1 gene Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. Indicus|evm.model.CM009515.1.500 Q4FAT7 BGLR_PIG 88.650 0.996937 1.00153 GUSB - Beta-glucuronidase precursor - Sus scrofa (Pig) - GUSB gene Plays an important role in the degradation of dermatan and keratan sulfates. Indicus|evm.model.CM009515.1.501 O97524 BGLR_FELCA 75.157 0.990909 0.675883 GUSB - Beta-glucuronidase precursor - Felis catus (Cat) - GUSB gene Plays an important role in the degradation of dermatan and keratan sulfates. Indicus|evm.model.CM009515.1.502 Q3SZJ0 ARLY_BOVIN 100.000 0.780165 1.27907 ASL - Argininosuccinate lyase - Bos taurus (Bovine) - ASL gene cytosol, argininosuccinate lyase activity, arginine biosynthetic process via ornithine Indicus|evm.model.CM009515.1.503 A0JN61 RPC9_BOVIN 99.324 0.686916 1.44595 CRCP - DNA-directed RNA polymerase III subunit RPC9 - Bos taurus (Bovine) - CRCP gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Indicus|evm.model.CM009515.1.504 O60507 TPST1_HUMAN 96.757 0.994609 1.0027 TPST1 - Protein-tyrosine sulfotransferase 1 - Homo sapiens (Human) - TPST1 gene Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. Indicus|evm.model.CM009515.1.505 O18973 RABX5_BOVIN 100.000 0.625478 1.59553 RABGEF1 - Rab5 GDP/GTP exchange factor - Bos taurus (Bovine) - RABGEF1 gene Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. Indicus|evm.model.CM009515.1.506 Q2YDM0 TM248_BOVIN 100.000 0.993651 1.00318 TMEM248 - Transmembrane protein 248 - Bos taurus (Bovine) - TMEM248 gene Indicus|evm.model.CM009515.1.507 Q3SWZ6 SBDS_BOVIN 100.000 0.992032 1.004 SBDS - Ribosome maturation protein SBDS - Bos taurus (Bovine) - SBDS gene Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). Indicus|evm.model.CM009515.1.508 Q5REF9 TYW1_PONAB 78.552 0.997041 0.923497 TYW1 - S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 - Pongo abelii (Sumatran orangutan) - TYW1 gene Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). Indicus|evm.model.CM009515.1.509 Q9BXU9 CABP8_HUMAN 100.000 0.990909 0.842912 CALN1 - Calcium-binding protein 8 - Homo sapiens (Human) - CALN1 gene Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning. Indicus|evm.model.CM009515.1.511 Q6IS24 GLT17_HUMAN 98.649 0.996146 0.867893 GALNT17 - Polypeptide N-acetylgalactosaminyltransferase 17 - Homo sapiens (Human) - GALNT17 gene May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Indicus|evm.model.CM009515.1.515 Q8WXX7 AUTS2_HUMAN 95.806 0.560099 0.640985 AUTS2 - Autism susceptibility gene 2 protein - Homo sapiens (Human) - AUTS2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). Indicus|evm.model.CM009515.1.520 Q8WXX7 AUTS2_HUMAN 88.806 0.984962 0.105639 AUTS2 - Autism susceptibility gene 2 protein - Homo sapiens (Human) - AUTS2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). Indicus|evm.model.CM009515.1.524 A6NHX0 CAST2_HUMAN 98.282 0.957096 0.920973 CASTOR2 - Cytosolic arginine sensor for mTORC1 subunit 2 - Homo sapiens (Human) - CASTOR2 gene Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. Indicus|evm.model.CM009515.1.525 Q96I51 RCC1L_HUMAN 92.241 0.995699 1.00216 RCC1L - RCC1-like G exchanging factor-like protein precursor - Homo sapiens (Human) - RCC1L gene Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (PubMed:27667664). Indicus|evm.model.CM009515.1.526 A4IFA3 GT2D2_BOVIN 99.684 0.997897 1.00105 GTF2IRD2 - General transcription factor II-I repeat domain-containing protein 2 - Bos taurus (Bovine) - GTF2IRD2 gene nucleus Indicus|evm.model.CM009515.1.527 O77774 NCF1_BOVIN 99.745 0.994911 1.00255 NCF1 - Neutrophil cytosol factor 1 - Bos taurus (Bovine) - NCF1 gene NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Indicus|evm.model.CM009515.1.529 Q9UHL9 GT2D1_HUMAN 93.542 0.997886 0.986444 GTF2IRD1 - General transcription factor II-I repeat domain-containing protein 1 - Homo sapiens (Human) - GTF2IRD1 gene May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). Indicus|evm.model.CM009515.1.530 Q9UDT6 CLIP2_HUMAN 93.021 0.927111 1.07553 CLIP2 - CAP-Gly domain-containing linker protein 2 - Homo sapiens (Human) - CLIP2 gene Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). Indicus|evm.model.CM009515.1.531 Q05B83 RFC2_BOVIN 99.716 0.994334 1.00284 RFC2 - Replication factor C subunit 2 - Bos taurus (Bovine) - RFC2 gene The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). Indicus|evm.model.CM009515.1.532 Q9JHL0 NTAL_MOUSE 63.033 0.976303 1.03941 Lat2 - Linker for activation of T-cells family member 2 - Mus musculus (Mouse) - Lat2 gene Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. Indicus|evm.model.CM009515.1.533 Q1JPH6 IF4H_BOVIN 100.000 0.991266 1.00439 EIF4H - Eukaryotic translation initiation factor 4H - Bos taurus (Bovine) - EIF4H gene Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity). Indicus|evm.model.CM009515.1.534 P53667 LIMK1_HUMAN 97.569 0.951987 0.933539 LIMK1 - LIM domain kinase 1 - Homo sapiens (Human) - LIMK1 gene Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). Indicus|evm.model.CM009515.1.535 P04985 ELN_BOVIN 94.891 0.178478 1.02008 ELN - Elastin precursor - Bos taurus (Bovine) - ELN gene Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). Indicus|evm.model.CM009515.1.537 Q2TBQ4 TM270_BOVIN 98.092 0.992395 1.00382 TMEM270 - Transmembrane protein 270 - Bos taurus (Bovine) - TMEM270 gene Indicus|evm.model.CM009515.1.538 Q8N6F8 MET27_HUMAN 80.288 0.841463 1.00408 METTL27 - Methyltransferase-like protein 27 - Homo sapiens (Human) - METTL27 gene methyltransferase activity Indicus|evm.model.CM009515.1.539 Q6BBL6 CLD4_BOVIN 100.000 0.990476 1.00478 CLDN4 - Claudin-4 - Bos taurus (Bovine) - CLDN4 gene Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009515.1.540 Q765N9 CLD3_BOVIN 100.000 0.990909 1.00457 CLDN3 - Claudin-3 - Bos taurus (Bovine) - CLDN3 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009515.1.541 Q3SZ73 ABHDB_BOVIN 99.340 0.993421 1.0033 ABHD11 - Protein ABHD11 - Bos taurus (Bovine) - ABHD11 gene mitochondrion Indicus|evm.model.CM009515.1.543 P32850 STX1A_BOVIN 100.000 0.99308 1.00347 STX1A - Syntaxin-1A - Bos taurus (Bovine) - STX1A gene Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion (By similarity). Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Plays also an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). Indicus|evm.model.CM009515.1.544 Q58DP0 BUD23_BOVIN 100.000 0.992908 1.00356 BUD23 - Probable 18S rRNA (guanine-N(7))-methyltransferase - Bos taurus (Bovine) - BUD23 gene S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro. Indicus|evm.model.CM009515.1.545 Q96LL9 DJC30_HUMAN 78.571 0.920705 1.00442 DNAJC30 - DnaJ homolog subfamily C member 30, mitochondrial precursor - Homo sapiens (Human) - DNAJC30 gene Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity). Indicus|evm.model.CM009515.1.546 Q86XT2 VP37D_HUMAN 96.618 0.985646 0.832669 VPS37D - Vacuolar protein sorting-associated protein 37D - Homo sapiens (Human) - VPS37D gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Indicus|evm.model.CM009515.1.547 Q9NP71 MLXPL_HUMAN 85.444 0.98133 1.00587 MLXIPL - Carbohydrate-responsive element-binding protein - Homo sapiens (Human) - MLXIPL gene Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity). Indicus|evm.model.CM009515.1.548 Q9Y4P3 TBL2_HUMAN 89.262 0.995526 1 TBL2 - Transducin beta-like protein 2 - Homo sapiens (Human) - TBL2 gene endoplasmic reticulum, integral component of endoplasmic reticulum membrane, phosphoprotein binding, protein kinase binding, RNA binding, translation initiation factor binding, cellular response to glucose starvation, cellular response to hypoxia, endoplasmic reticulum unfolded protein response Indicus|evm.model.CM009515.1.549 Q3T0A6 BCL7B_BOVIN 100.000 0.990148 1.00495 BCL7B - B-cell CLL/lymphoma 7 protein family member B - Bos taurus (Bovine) - BCL7B gene Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1. Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation. May play a role in lung tumor development or progression. Indicus|evm.model.CM009515.1.550 Q9UIG0 BAZ1B_HUMAN 94.740 0.998651 1 BAZ1B - Tyrosine-protein kinase BAZ1B - Homo sapiens (Human) - BAZ1B gene Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. Indicus|evm.model.CM009515.1.551 O00144 FZD9_HUMAN 91.392 0.99633 0.922166 FZD9 - Frizzled-9 precursor - Homo sapiens (Human) - FZD9 gene Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). Indicus|evm.model.CM009515.1.552 A6QQ71 FKBP6_BOVIN 96.308 0.987805 1.00613 FKBP6 - Inactive peptidyl-prolyl cis-trans isomerase FKBP6 - Bos taurus (Bovine) - FKBP6 gene Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). Indicus|evm.model.CM009515.1.553 Q865W2 TRI50_PIG 93.224 0.995902 1.00412 TRIM50 - E3 ubiquitin-protein ligase TRIM50 - Sus scrofa (Pig) - TRIM50 gene E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. Indicus|evm.model.CM009515.1.554 Q96P11 NSUN5_HUMAN 87.681 0.892009 1.07925 NSUN5 - 28S rRNA (cytosine-C(5))-methyltransferase - Homo sapiens (Human) - NSUN5 gene S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity). Indicus|evm.model.CM009515.1.555 Q6PJE2 POZP3_HUMAN 76.000 0.0598852 6.51872 POMZP3 - POM121 and ZP3 fusion protein - Homo sapiens (Human) - POMZP3 gene extracellular matrix, nuclear membrane, nucleoplasm, acrosin binding, binding of sperm to zona pellucida, egg coat formation, positive regulation of acrosome reaction Indicus|evm.model.CM009515.1.556 O00291 HIP1_HUMAN 86.187 0.99811 1.02025 HIP1 - Huntingtin-interacting protein 1 - Homo sapiens (Human) - HIP1 gene Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). Indicus|evm.model.CM009515.1.557 Q64H35 CCL26_CANLF 69.892 0.968421 1.01064 CCL26 - C-C motif chemokine 26 precursor - Canis lupus familiaris (Dog) - CCL26 gene Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils. Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis. Indicus|evm.model.CM009515.1.558 P79251 VATG1_BOVIN 71.429 0.837838 0.627119 ATP6V1G1 - V-type proton ATPase subunit G 1 - Bos taurus (Bovine) - ATP6V1G1 gene Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). Indicus|evm.model.CM009515.1.559 Q68Y86 CCL24_CANLF 59.664 0.982906 0.983193 CCL24 - C-C motif chemokine 24 precursor - Canis lupus familiaris (Dog) - CCL24 gene Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3. Indicus|evm.model.CM009515.1.560 Q6NTF9 RHBD2_HUMAN 85.399 0.991781 1.00275 RHBDD2 - Rhomboid domain-containing protein 2 - Homo sapiens (Human) - RHBDD2 gene Golgi apparatus, Hrd1p ubiquitin ligase ERAD-L complex, integral component of endoplasmic reticulum membrane, nucleoplasm, misfolded protein binding, ubiquitin-specific protease binding, endoplasmic reticulum unfolded protein response, ubiquitin-dependent ERAD pathway Indicus|evm.model.CM009515.1.561 Q5R9Q7 RL9_PONAB 65.979 0.979381 0.505208 RPL9 - 60S ribosomal protein L9 - Pongo abelii (Sumatran orangutan) - RPL9 gene Indicus|evm.model.CM009515.1.562 E2RQ08 RPN1_CANLF 68.571 0.853933 0.146623 RPN1 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor - Canis lupus familiaris (Dog) - RPN1 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Indicus|evm.model.CM009515.1.563 Q3SYT8 NCPR_BOVIN 97.788 0.993994 0.982301 POR - NADPH--cytochrome P450 reductase - Bos taurus (Bovine) - POR gene This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Indicus|evm.model.CM009515.1.564 Q05B45 TACAN_BOVIN 100.000 0.994186 1.00292 TMEM120A - Ion channel TACAN - Bos taurus (Bovine) - TMEM120A gene Ion channel involved in sensing mechanical pain. Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli. May also be required for efficient adipogenesis. Indicus|evm.model.CM009515.1.565 Q9Y6J8 STYL1_HUMAN 72.143 0.99278 0.884984 STYXL1 - Serine/threonine/tyrosine-interacting-like protein 1 - Homo sapiens (Human) - STYXL1 gene Catalytically inactive phosphatase (PubMed:20180778, PubMed:23163895). By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules (PubMed:20180778, PubMed:23163895). Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity (PubMed:24709986). By inhibiting PTPMT1, positively regulates intrinsic apoptosis (PubMed:21262771). May play a role in the formation of neurites during neuronal development (PubMed:29250526). Indicus|evm.model.CM009515.1.566 Q32LG3 MDHM_BOVIN 100.000 0.9941 1.00296 MDH2 - Malate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - MDH2 gene cytoplasm, mitochondrial matrix, mitochondrion, L-malate dehydrogenase activity, protein homodimerization activity, aerobic respiration, tricarboxylic acid cycle Indicus|evm.model.CM009515.1.567 A6NNA2 SRRM3_HUMAN 90.964 0.546218 0.99665 SRRM3 - Serine/arginine repetitive matrix protein 3 - Homo sapiens (Human) - SRRM3 gene May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911). Indicus|evm.model.CM009515.1.568 Q3T149 HSPB1_BOVIN 100.000 0.990099 1.00498 HSPB1 - Heat shock protein beta-1 - Bos taurus (Bovine) - HSPB1 gene Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Indicus|evm.model.CM009515.1.569 P61983 1433G_RAT 100.000 0.991935 1.00405 Ywhag - 14-3-3 protein gamma - Rattus norvegicus (Rat) - Ywhag gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Indicus|evm.model.CM009515.1.570 Q8WTU2 SRB4D_HUMAN 90.435 0.97774 1.01565 SSC4D - Scavenger receptor cysteine-rich domain-containing group B protein precursor - Homo sapiens (Human) - SSC4D gene Indicus|evm.model.CM009515.1.571 P48830 ZP3_BOVIN 99.287 0.995261 1.00238 ZP3 - Zona pellucida sperm-binding protein 3 precursor - Bos taurus (Bovine) - ZP3 gene Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. Indicus|evm.model.CM009515.1.572 Q86UW9 DTX2_HUMAN 90.514 0.996774 0.996785 DTX2 - Probable E3 ubiquitin-protein ligase DTX2 - Homo sapiens (Human) - DTX2 gene Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Indicus|evm.model.CM009515.1.573 Q864V4 UPK3B_BOVIN 100.000 0.992857 1.00358 UPK3B - Uroplakin-3b precursor - Bos taurus (Bovine) - UPK3B gene Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). Indicus|evm.model.CM009515.1.574 A6QQ85 UPK3L_BOVIN 98.814 0.992126 1.00395 UPK3BL1 - Uroplakin-3b-like protein 1 precursor - Bos taurus (Bovine) - UPK3BL1 gene integral component of membrane Indicus|evm.model.CM009515.1.575 O43374 RASL2_HUMAN 90.421 0.984868 0.987547 RASA4 - Ras GTPase-activating protein 4 - Homo sapiens (Human) - RASA4 gene Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. Indicus|evm.model.CM009515.1.576 P52435 RPB11_HUMAN 100.000 0.983051 1.00855 POLR2J - DNA-directed RNA polymerase II subunit RPB11-a - Homo sapiens (Human) - POLR2J gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). Indicus|evm.model.CM009515.1.577 Q9UFC0 LRWD1_HUMAN 79.199 0.992272 1 LRWD1 - Leucine-rich repeat and WD repeat-containing protein 1 - Homo sapiens (Human) - LRWD1 gene Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. Indicus|evm.model.CM009515.1.578 Q9NXW9 ALKB4_HUMAN 86.093 0.990132 1.00662 ALKBH4 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 - Homo sapiens (Human) - ALKBH4 gene Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity). Indicus|evm.model.CM009515.1.579 Q96SN7 ORAI2_HUMAN 97.638 0.992157 1.00394 ORAI2 - Protein orai-2 - Homo sapiens (Human) - ORAI2 gene Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. Indicus|evm.model.CM009515.1.580 Q2KIT1 PKRI1_BOVIN 98.925 0.989305 1.00538 PRKRIP1 - PRKR-interacting protein 1 - Bos taurus (Bovine) - PRKRIP1 gene Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity). Indicus|evm.model.CM009515.1.581 P62315 SMD1_MOUSE 91.209 0.576923 1.31092 Snrpd1 - Small nuclear ribonucleoprotein Sm D1 - Mus musculus (Mouse) - Snrpd1 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. Indicus|evm.model.CM009515.1.582 O14492 SH2B2_HUMAN 98.214 0.0985663 0.882911 SH2B2 - SH2B adapter protein 2 - Homo sapiens (Human) - SH2B2 gene Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. Indicus|evm.model.CM009515.1.583 Q5R8V1 CASP_PONAB 97.744 0.252378 2.32596 CUTL1 - Protein CASP - Pongo abelii (Sumatran orangutan) - CUTL1 gene May be involved in intra-Golgi retrograde transport. Indicus|evm.model.CM009515.1.584 Q62082 MYL10_MOUSE 100.000 0.978102 0.678218 Myl10 - Myosin regulatory light chain 10 - Mus musculus (Mouse) - Myl10 gene mitochondrion Indicus|evm.model.CM009515.1.585 Q96A83 COQA1_HUMAN 87.220 0.863889 0.816327 COL26A1 - Collagen alpha-1(XXVI) chain precursor - Homo sapiens (Human) - COL26A1 gene collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular region, plasma membrane, collagen fibril organization Indicus|evm.model.CM009515.1.586 Q86VF5 MOGT3_HUMAN 78.947 0.0767635 1.41349 MOGAT3 - 2-acylglycerol O-acyltransferase 3 - Homo sapiens (Human) - MOGAT3 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Indicus|evm.model.CM009515.1.587 Q5E9J4 IFT22_BOVIN 98.919 0.989247 1.00541 IFT22 - Intraflagellar transport protein 22 homolog - Bos taurus (Bovine) - IFT22 gene Small GTPase-like component of the intraflagellar transport (IFT) complex B. Indicus|evm.model.CM009515.1.588 Q3T0I5 FIS1_BOVIN 100.000 0.986928 1.00658 FIS1 - Mitochondrial fission 1 protein - Bos taurus (Bovine) - FIS1 gene Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity). Indicus|evm.model.CM009515.1.589 Q2KIY2 CLD15_BOVIN 99.574 0.991525 1.00426 CLDN15 - Claudin-15 - Bos taurus (Bovine) - CLDN15 gene Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake (By similarity). Indicus|evm.model.CM009515.1.590 O43257 ZNHI1_HUMAN 100.000 0.987097 1.00649 ZNHIT1 - Zinc finger HIT domain-containing protein 1 - Homo sapiens (Human) - ZNHIT1 gene Seems to play a role in p53-mediated apoptosis induction (PubMed:17380123). Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity (PubMed:17892483). Indicus|evm.model.CM009515.1.591 Q5R6K5 PLOD3_PONAB 94.986 0.953457 1.01897 PLOD3 - Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor - Pongo abelii (Sumatran orangutan) - PLOD3 gene Multifunctional enzyme that catalyzes a series of post-translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the ADIPOQ collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV collagens. Essential for normal formation of basement membranes (By similarity). Indicus|evm.model.CM009515.1.592 Q86VF5 MOGT3_HUMAN 72.131 0.967742 0.181818 MOGAT3 - 2-acylglycerol O-acyltransferase 3 - Homo sapiens (Human) - MOGAT3 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Indicus|evm.model.CM009515.1.593 Q86VF5 MOGT3_HUMAN 71.554 0.994152 1.00293 MOGAT3 - 2-acylglycerol O-acyltransferase 3 - Homo sapiens (Human) - MOGAT3 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Indicus|evm.model.CM009515.1.594 Q86VF5 MOGT3_HUMAN 55.114 0.877193 0.501466 MOGAT3 - 2-acylglycerol O-acyltransferase 3 - Homo sapiens (Human) - MOGAT3 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Indicus|evm.model.CM009515.1.596 Q9H195 MUC3B_HUMAN 56.623 0.164783 1.85934 MUC3B - Mucin-3B precursor - Homo sapiens (Human) - MUC3B gene Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity). Indicus|evm.model.CM009515.1.597 P86435 VGF_BOVIN 99.754 0.93318 0.702265 VGF - Neurosecretory protein VGF precursor - Bos taurus (Bovine) - VGF gene Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). Indicus|evm.model.CM009515.1.598 P61967 AP1S1_MOUSE 100.000 0.987342 1 Ap1s1 - AP-1 complex subunit sigma-1A - Mus musculus (Mouse) - Ap1s1 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Indicus|evm.model.CM009515.1.599 P13909 PAI1_BOVIN 100.000 0.783203 1.27363 SERPINE1 - Plasminogen activator inhibitor 1 precursor - Bos taurus (Bovine) - SERPINE1 gene Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity). Indicus|evm.model.CM009515.1.600 E1BD59 TRI56_BOVIN 96.821 0.997354 1.03279 TRIM56 - E3 ubiquitin-protein ligase TRIM56 - Bos taurus (Bovine) - TRIM56 gene E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (By similarity). Restricts bovine viral diarrhea virus (BVDV) replication (PubMed:21289118). Indicus|evm.model.CM009515.1.601 Q9UKN1 MUC12_HUMAN 60.837 0.790909 0.060241 MUC12 - Mucin-12 precursor - Homo sapiens (Human) - MUC12 gene Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. Indicus|evm.model.CM009515.1.604 P23795 ACES_BOVIN 99.837 0.996743 1.00163 ACHE - Acetylcholinesterase precursor - Bos taurus (Bovine) - ACHE gene Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Indicus|evm.model.CM009515.1.605 Q6NVU6 UFSP1_HUMAN 85.915 0.986014 1.00704 UFSP1 - Inactive Ufm1-specific protease 1 - Homo sapiens (Human) - UFSP1 gene Indicus|evm.model.CM009515.1.606 Q3SX26 TRIP6_BOVIN 99.777 0.331606 2.80873 TRIP6 - Thyroid receptor-interacting protein 6 - Bos taurus (Bovine) - TRIP6 gene Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity). Indicus|evm.model.CM009515.1.607 Q9BXP2 S12A9_HUMAN 93.107 0.997814 1.00109 SLC12A9 - Solute carrier family 12 member 9 - Homo sapiens (Human) - SLC12A9 gene May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function. Indicus|evm.model.CM009515.1.608 P54760 EPHB4_HUMAN 96.049 0.997976 1.00101 EPHB4 - Ephrin type-B receptor 4 precursor - Homo sapiens (Human) - EPHB4 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. Indicus|evm.model.CM009515.1.609 P48617 EPO_BOVIN 100.000 0.0633499 15.7031 EPO - Erythropoietin precursor - Bos taurus (Bovine) - EPO gene Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Indicus|evm.model.CM009515.1.610 Q0II25 POP7_BOVIN 100.000 0.985816 1.00714 POP7 - Ribonuclease P protein subunit p20 - Bos taurus (Bovine) - POP7 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Indicus|evm.model.CM009515.1.612 O75420 GGYF1_HUMAN 91.475 0.998071 1.00193 GIGYF1 - GRB10-interacting GYF protein 1 - Homo sapiens (Human) - GIGYF1 gene May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). Indicus|evm.model.CM009515.1.613 P54313 GBB2_RAT 100.000 0.994135 1.00294 Gnb2 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 - Rattus norvegicus (Rat) - Gnb2 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009515.1.614 P86173 ACL6B_RAT 100.000 0.995316 1.00235 Actl6b - Actin-like protein 6B - Rattus norvegicus (Rat) - Actl6b gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Essential for neuronal maturation and dendrite development (By similarity). Indicus|evm.model.CM009515.1.615 Q9UP52 TFR2_HUMAN 86.476 0.997512 1.00375 TFR2 - Transferrin receptor protein 2 - Homo sapiens (Human) - TFR2 gene Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Indicus|evm.model.CM009515.1.616 Q3T033 MSPD3_BOVIN 100.000 0.991525 1.00426 MOSPD3 - Motile sperm domain-containing protein 3 - Bos taurus (Bovine) - MOSPD3 gene endoplasmic reticulum membrane, plasma membrane, FFAT motif binding, endoplasmic reticulum membrane organization, endoplasmic reticulum-plasma membrane tethering Indicus|evm.model.CM009515.1.617 Q15113 PCOC1_HUMAN 83.223 0.995575 1.00668 PCOLCE - Procollagen C-endopeptidase enhancer 1 precursor - Homo sapiens (Human) - PCOLCE gene Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. Indicus|evm.model.CM009515.1.618 Q4R327 FBX24_MACFA 90.989 0.952782 1.02241 FBXO24 - F-box only protein 24 - Macaca fascicularis (Crab-eating macaque) - FBXO24 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009515.1.619 O75427 LRCH4_HUMAN 86.526 0.931715 0.964861 LRCH4 - Leucine-rich repeat and calponin homology domain-containing protein 4 - Homo sapiens (Human) - LRCH4 gene PML body, nervous system development Indicus|evm.model.CM009515.1.620 Q8TEE9 SAP25_HUMAN 65.686 0.667785 1.49749 SAP25 - Histone deacetylase complex subunit SAP25 - Homo sapiens (Human) - SAP25 gene Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex. Indicus|evm.model.CM009515.1.621 Q6P4Y6 IRS1_XENTR 50.633 0.429644 0.814985 irs1 - Insulin receptor substrate 1 - Xenopus tropicalis (Western clawed frog) - irs1 gene May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). Indicus|evm.model.CM009515.1.622 O95081 AGFG2_HUMAN 86.469 0.962887 1.00832 AGFG2 - Arf-GAP domain and FG repeat-containing protein 2 - Homo sapiens (Human) - AGFG2 gene membrane Indicus|evm.model.CM009515.1.623 Q6ZVC0 NYAP1_HUMAN 92.807 0.997636 1.00595 NYAP1 - Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 - Homo sapiens (Human) - NYAP1 gene Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. Indicus|evm.model.CM009515.1.625 Q3B8N7 T22D4_RAT 83.855 0.995192 1.07494 Tsc22d4 - TSC22 domain family protein 4 - Rattus norvegicus (Rat) - Tsc22d4 gene Transcriptional repressor. Indicus|evm.model.CM009515.1.626 Q2T9X5 CG061_BOVIN 99.510 0.990244 1.0049 Uncharacterized protein C7orf61 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009515.1.627 A6QPM6 PPR35_BOVIN 99.248 0.992509 1.00376 PPP1R35 - Protein phosphatase 1 regulatory subunit 35 - Bos taurus (Bovine) - PPP1R35 gene Inhibits PPP1CA phosphatase activity. Indicus|evm.model.CM009515.1.628 Q7L2J0 MEPCE_HUMAN 90.145 0.997093 0.998549 MEPCE - 7SK snRNA methylphosphate capping enzyme - Homo sapiens (Human) - MEPCE gene S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Indicus|evm.model.CM009515.1.629 Q9H0M4 ZCPW1_HUMAN 67.077 0.984472 0.993827 ZCWPW1 - Zinc finger CW-type PWWP domain protein 1 - Homo sapiens (Human) - ZCWPW1 gene Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3) (PubMed:32744506, PubMed:20826339). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (By similarity). Essential for male fertility and spermatogenesis (By similarity). Required for meiosis prophase I progression in male but not in female germ cells (By similarity). Indicus|evm.model.CM009515.1.630 Q9UKJ1 PILRA_HUMAN 50.903 0.893333 0.990099 PILRA - Paired immunoglobulin-like type 2 receptor alpha precursor - Homo sapiens (Human) - PILRA gene Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. Indicus|evm.model.CM009515.1.631 Q6DKI7 PVRIG_HUMAN 58.766 0.980707 0.953988 PVRIG - Transmembrane protein PVRIG - Homo sapiens (Human) - PVRIG gene Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. Indicus|evm.model.CM009515.1.632 Q9UJ98 STAG3_HUMAN 85.493 0.982272 1.01306 STAG3 - Cohesin subunit SA-3 - Homo sapiens (Human) - STAG3 gene Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Indicus|evm.model.CM009515.1.633 Q8N158 GPC2_HUMAN 74.956 0.965458 1 GPC2 - Glypican-2 precursor - Homo sapiens (Human) - GPC2 gene Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity). Indicus|evm.model.CM009515.1.634 Q5E9W5 G3ST4_BOVIN 99.793 0.995868 1.00207 GAL3ST4 - Galactose-3-O-sulfotransferase 4 - Bos taurus (Bovine) - GAL3ST4 gene Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc (By similarity). Indicus|evm.model.CM009515.1.635 Q8WVR3 TPC14_HUMAN 97.759 0.996558 1.00172 TRAPPC14 - Trafficking protein particle complex subunit 14 - Homo sapiens (Human) - TRAPPC14 gene Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (PubMed:31467083, PubMed:30715179). TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis (PubMed:31467083). Modulates YAP1 activity as transcriptional regulator (PubMed:30447097). Indicus|evm.model.CM009515.1.636 Q2M2U3 LTOR4_BOVIN 100.000 0.98 1.0101 LAMTOR4 - Ragulator complex protein LAMTOR4 - Bos taurus (Bovine) - LAMTOR4 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). Indicus|evm.model.CM009515.1.638 Q9UKJ1 PILRA_HUMAN 49.091 0.683007 1.0099 PILRA - Paired immunoglobulin-like type 2 receptor alpha precursor - Homo sapiens (Human) - PILRA gene Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. Indicus|evm.model.CM009515.1.639 Q2HJB0 MBLC1_BOVIN 100.000 0.992424 1.0038 MBLAC1 - Metallo-beta-lactamase domain-containing protein 1 - Bos taurus (Bovine) - MBLAC1 gene Indicus|evm.model.CM009515.1.640 Q3SWX1 CNPY4_BOVIN 100.000 0.991667 1.00418 CNPY4 - Protein canopy homolog 4 precursor - Bos taurus (Bovine) - CNPY4 gene Plays a role in the regulation of the cell surface expression of TLR4. Indicus|evm.model.CM009515.1.641 Q63801 TAF6_RAT 97.489 0.995582 1.00147 Taf6 - Transcription initiation factor TFIID subunit 6 - Rattus norvegicus (Rat) - Taf6 gene TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (By similarity). Indicus|evm.model.CM009515.1.642 Q29RY8 AP4M1_BOVIN 100.000 0.995585 1.00221 AP4M1 - AP-4 complex subunit mu-1 - Bos taurus (Bovine) - AP4M1 gene Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal. Indicus|evm.model.CM009515.1.643 Q3ZBH9 MCM7_BOVIN 100.000 0.997222 1.00139 MCM7 - DNA replication licensing factor MCM7 - Bos taurus (Bovine) - MCM7 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Indicus|evm.model.CM009515.1.644 A6QQ21 CSN6_BOVIN 99.691 0.993846 1.00309 COPS6 - COP9 signalosome complex subunit 6 - Bos taurus (Bovine) - COPS6 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Has some glucocorticoid receptor-responsive activity (By similarity). Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN (By similarity). Indicus|evm.model.CM009515.1.645 P17036 ZNF3_HUMAN 90.380 0.995536 1.00448 ZNF3 - Zinc finger protein 3 - Homo sapiens (Human) - ZNF3 gene Involved in cell differentiation and/or proliferation. Indicus|evm.model.CM009515.1.646 A2T7L7 ZSC21_PONPY 83.898 0.991525 0.997886 ZSCAN21 - Zinc finger and SCAN domain-containing protein 21 - Pongo pygmaeus (Bornean orangutan) - ZSCAN21 gene Strong transcriptional activator (By similarity). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity). Indicus|evm.model.CM009515.1.647 Q5R670 ZKSC1_PONAB 91.652 0.996454 1.00178 ZKSCAN1 - Zinc finger protein with KRAB and SCAN domains 1 - Pongo abelii (Sumatran orangutan) - ZKSCAN1 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.648 Q3ZCH5 ZA2G_BOVIN 99.666 0.993333 1.00334 AZGP1 - Zinc-alpha-2-glycoprotein precursor - Bos taurus (Bovine) - AZGP1 gene Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. Indicus|evm.model.CM009515.1.649 A3KN25 CXG3_BOVIN 100.000 0.992754 1.00364 GJC3 - Gap junction gamma-3 protein - Bos taurus (Bovine) - GJC3 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009515.1.650 P79102 CP3AS_BOVIN 99.252 0.581395 1.357 CYP3A28 - Cytochrome P450 3A28 - Bos taurus (Bovine) - CYP3A28 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Indicus|evm.model.CM009515.1.651 Q8NHA4 O2AE1_HUMAN 83.750 0.937313 1.03715 OR2AE1 - Olfactory receptor 2AE1 - Homo sapiens (Human) - OR2AE1 gene Odorant receptor. Indicus|evm.model.CM009515.1.652 Q9C037 TRIM4_HUMAN 76.923 0.858407 0.452 TRIM4 - E3 ubiquitin-protein ligase TRIM4 - Homo sapiens (Human) - TRIM4 gene E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction. Indicus|evm.model.CM009515.1.653 A8D8X1 RL10_SHEEP 73.750 0.669492 0.551402 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009515.1.654 Q29496 CP3AO_SHEEP 91.849 0.996032 1.00199 CYP3A24 - Cytochrome P450 3A24 - Ovis aries (Sheep) - CYP3A24 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Indicus|evm.model.CM009515.1.655 Q29496 CP3AO_SHEEP 92.843 0.996032 1.00199 CYP3A24 - Cytochrome P450 3A24 - Ovis aries (Sheep) - CYP3A24 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Indicus|evm.model.CM009515.1.656 Q29496 CP3AO_SHEEP 85.487 0.995585 0.900596 CYP3A24 - Cytochrome P450 3A24 - Ovis aries (Sheep) - CYP3A24 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Indicus|evm.model.CM009515.1.657 Q6NSZ9 ZSC25_HUMAN 83.978 0.952548 1.04596 ZSCAN25 - Zinc finger and SCAN domain-containing protein 25 - Homo sapiens (Human) - ZSCAN25 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.658 P0DP42 T225B_HUMAN 73.303 0.969163 1.02715 TMEM225B - Transmembrane protein 225B - Homo sapiens (Human) - TMEM225B gene Indicus|evm.model.CM009515.1.660 Q8N720 ZN655_HUMAN 86.667 0.0715447 1.25255 ZNF655 - Zinc finger protein 655 - Homo sapiens (Human) - ZNF655 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.661 Q8TCP9 F200A_HUMAN 88.021 0.996534 1.00698 FAM200A - Protein FAM200A - Homo sapiens (Human) - FAM200A gene Indicus|evm.model.CM009515.1.662 Q5FWF6 ZN789_HUMAN 70.353 0.961451 1.03765 ZNF789 - Zinc finger protein 789 - Homo sapiens (Human) - ZNF789 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.663 A2T7D2 ZKSC5_PANTR 85.697 0.997599 0.992849 ZKSCAN5 - Zinc finger protein with KRAB and SCAN domains 5 - Pan troglodytes (Chimpanzee) - ZKSCAN5 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.664 Q53GI3 ZN394_HUMAN 71.296 0.33437 1.14617 ZNF394 - Zinc finger protein 394 - Homo sapiens (Human) - ZNF394 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.665 Q28851 ATPK_BOVIN 100.000 0.977528 1.01136 ATP5MF - ATP synthase subunit f, mitochondrial - Bos taurus (Bovine) - ATP5MF gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Indicus|evm.model.CM009515.1.666 O95639 CPSF4_HUMAN 99.257 0.992593 1.00372 CPSF4 - Cleavage and polyadenylation specificity factor subunit 4 - Homo sapiens (Human) - CPSF4 gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). Indicus|evm.model.CM009515.1.667 O75127 PTCD1_HUMAN 77.730 0.923684 1.08571 PTCD1 - Pentatricopeptide repeat-containing protein 1, mitochondrial - Homo sapiens (Human) - PTCD1 gene Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs. Indicus|evm.model.CM009515.1.668 O70454 BUD31_RAT 100.000 0.986207 1.00694 Bud31 - Protein BUD31 homolog - Rattus norvegicus (Rat) - Bud31 gene Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. Indicus|evm.model.CM009515.1.669 Q13442 HAP28_HUMAN 98.901 0.989071 1.01105 PDAP1 - 28 kDa heat- and acid-stable phosphoprotein - Homo sapiens (Human) - PDAP1 gene Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. Indicus|evm.model.CM009515.1.670 Q58CQ2 ARC1B_BOVIN 99.731 0.994638 1.00269 ARPC1B - Actin-related protein 2/3 complex subunit 1B - Bos taurus (Bovine) - ARPC1B gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Indicus|evm.model.CM009515.1.671 Q1JP79 ARC1A_BOVIN 100.000 0.994609 1.0027 ARPC1A - Actin-related protein 2/3 complex subunit 1A - Bos taurus (Bovine) - ARPC1A gene Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). Indicus|evm.model.CM009515.1.672 F1PT61 MYH16_CANLF 77.778 0.0276899 0.654922 MYH16 - Myosin-16 - Canis lupus familiaris (Dog) - MYH16 gene May play a role in masticatory muscles contraction. Indicus|evm.model.CM009515.1.673 C1JZ66 IMA8_BOVIN 100.000 0.904673 1.0249 KPNA7 - Importin subunit alpha-8 - Bos taurus (Bovine) - KPNA7 gene Functions in nuclear protein import. Indicus|evm.model.CM009515.1.674 Q9CUN6 SMUF1_MOUSE 97.759 0.959623 1.01642 Smurf1 - E3 ubiquitin-protein ligase SMURF1 - Mus musculus (Mouse) - Smurf1 gene E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway (By similarity). Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (By similarity). Indicus|evm.model.CM009515.1.675 Q80YV3 TRRAP_MOUSE 97.730 0.663117 1.50097 Trrap - Transformation/transcription domain-associated protein - Mus musculus (Mouse) - Trrap gene Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). Indicus|evm.model.CM009515.1.676 Q8N3G9 TM130_HUMAN 85.990 0.976359 0.972414 TMEM130 - Transmembrane protein 130 precursor - Homo sapiens (Human) - TMEM130 gene Golgi apparatus, integral component of plasma membrane Indicus|evm.model.CM009515.1.678 P47972 NPTX2_HUMAN 92.519 0.995025 0.932715 NPTX2 - Neuronal pentraxin-2 precursor - Homo sapiens (Human) - NPTX2 gene Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). Indicus|evm.model.CM009515.1.679 Q9DBJ3 BI2L1_MOUSE 78.295 0.99596 0.963035 Baiap2l1 - Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 - Mus musculus (Mouse) - Baiap2l1 gene May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity). Indicus|evm.model.CM009515.1.680 E1BZR9 TCPR1_CHICK 74.380 0.473477 0.43393 TECPR1 - Tectonin beta-propeller repeat-containing protein 1 - Gallus gallus (Chicken) - TECPR1 gene Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes. Binds phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes (By similarity). Indicus|evm.model.CM009515.1.681 Q7Z6L1 TCPR1_HUMAN 83.846 0.875211 0.509013 TECPR1 - Tectonin beta-propeller repeat-containing protein 1 - Homo sapiens (Human) - TECPR1 gene Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. Indicus|evm.model.CM009515.1.682 Q8IWU2 LMTK2_HUMAN 75.136 0.863177 1.11843 LMTK2 - Serine/threonine-protein kinase LMTK2 - Homo sapiens (Human) - LMTK2 gene Phosphorylates PPP1C, phosphorylase b and CFTR. Indicus|evm.model.CM009515.1.683 O35508 ONCO_CAVPO 95.699 0.884615 0.954128 OCM - Oncomodulin - Cavia porcellus (Guinea pig) - OCM gene Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions (By similarity). Indicus|evm.model.CM009515.1.684 Q0VD30 CCZ1_BOVIN 100.000 0.995842 1.00208 CCZ1 - Vacuolar fusion protein CCZ1 homolog - Bos taurus (Bovine) - CCZ1 gene Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Indicus|evm.model.CM009515.1.685 Q1JPG1 RS10B_BOVIN 95.652 0.997368 0.904762 RSPH10B - Radial spoke head 10 homolog B - Bos taurus (Bovine) - RSPH10B gene Indicus|evm.model.CM009515.1.686 O95744 PM2P2_HUMAN 82.486 0.187432 3.10774 PMS2P2 - Putative postmeiotic segregation increased 2-like protein 2 - Homo sapiens (Human) - PMS2P2 gene mismatch repair complex, MutLalpha complex, ATPase activity, mismatch repair, somatic hypermutation of immunoglobulin genes Indicus|evm.model.CM009515.1.687 Q0II26 AIMP2_BOVIN 100.000 0.993769 1.00313 AIMP2 - Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 - Bos taurus (Bovine) - AIMP2 gene Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. Indicus|evm.model.CM009515.1.688 Q9BQI3 E2AK1_HUMAN 81.111 0.993681 1.00476 EIF2AK1 - Eukaryotic translation initiation factor 2-alpha kinase 1 - Homo sapiens (Human) - EIF2AK1 gene Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes (By similarity). May also regulate endoplasmic reticulum (ER) stress during acute heme-deficient conditions (By similarity). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Indicus|evm.model.CM009515.1.690 E1B9W9 UBP42_BOVIN 100.000 0.997738 0.994749 USP42 - Ubiquitin carboxyl-terminal hydrolase 42 - Bos taurus (Bovine) - USP42 gene Deubiquitinating enzyme which may play an important role during spermatogenesis. Indicus|evm.model.CM009515.1.691 P97696 CYH3_RAT 85.496 0.963158 0.95 Cyth3 - Cytohesin-3 - Rattus norvegicus (Rat) - Cyth3 gene Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). Indicus|evm.model.CM009515.1.692 Q14331 FRG1_HUMAN 74.432 0.80791 0.686047 FRG1 - Protein FRG1 - Homo sapiens (Human) - FRG1 gene Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Indicus|evm.model.CM009515.1.695 Q6RUV5 RAC1_RAT 100.000 0.675472 1.38021 Rac1 - Ras-related C3 botulinum toxin substrate 1 precursor - Rattus norvegicus (Rat) - Rac1 gene Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:16040606, PubMed:16549782). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (By similarity). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:16040606). In glioma cells, promotes cell migration and invasion (PubMed:20696765). In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning (PubMed:19029984). Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). In neurons, is involved in dendritic spine formation and synaptic plasticity (PubMed:25498153). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (PubMed:12695502). In synapses, may mediate the regulation of F-actin cluster formation performed by SHANK3 (PubMed:24089484). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (PubMed:25284783). Indicus|evm.model.CM009515.1.696 Q5U305 ERD22_RAT 89.552 0.20135 4.1934 Kdelr2 - ER lumen protein-retaining receptor 2 - Rattus norvegicus (Rat) - Kdelr2 gene Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity). Indicus|evm.model.CM009515.1.697 Q0QWG9 GRD2I_MOUSE 91.837 0.0375 1.06401 Grid2ip - Delphilin - Mus musculus (Mouse) - Grid2ip gene Postsynaptic scaffolding protein at the Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. Indicus|evm.model.CM009515.1.699 Q58DT3 ZDHC4_BOVIN 99.708 0.934426 1.06706 ZDHHC4 - Palmitoyltransferase ZDHHC4 - Bos taurus (Bovine) - ZDHHC4 gene Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2. Indicus|evm.model.CM009515.1.700 Q96N11 CG026_HUMAN 93.304 0.993318 1 C7orf26 - Uncharacterized protein C7orf26 - Homo sapiens (Human) - C7orf26 gene Indicus|evm.model.CM009515.1.702 A6NFI3 ZN316_HUMAN 79.926 0.795349 0.64243 ZNF316 - Zinc finger protein 316 - Homo sapiens (Human) - ZNF316 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009515.1.703 P17014 ZNF12_HUMAN 89.413 0.712821 1.39885 ZNF12 - Zinc finger protein 12 - Homo sapiens (Human) - ZNF12 gene Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity. Indicus|evm.model.CM009515.1.704 Q9NYW8 RBAK_HUMAN 86.592 0.731481 1.36134 RBAK - RB-associated KRAB zinc finger protein - Homo sapiens (Human) - RBAK gene May repress E2F-dependent transcription. May promote AR-dependent transcription. Indicus|evm.model.CM009515.1.706 Q96KK4 O10C1_HUMAN 45.659 0.95092 1.04487 OR10C1 - Olfactory receptor 10C1 - Homo sapiens (Human) - OR10C1 gene Odorant receptor. Indicus|evm.model.CM009515.1.709 Q9NWF9 RN216_HUMAN 82.632 0.997843 1.07044 RNF216 - E3 ubiquitin-protein ligase RNF216 - Homo sapiens (Human) - RNF216 gene Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. Indicus|evm.model.CM009515.1.710 Q16658 FSCN1_HUMAN 93.103 0.995951 1.00203 FSCN1 - Fascin - Homo sapiens (Human) - FSCN1 gene Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). Indicus|evm.model.CM009515.1.711 P60710 ACTB_MOUSE 100.000 0.994681 1.00267 Actb - Actin, cytoplasmic 1 - Mus musculus (Mouse) - Actb gene Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:23558171, PubMed:25759381). Indicus|evm.model.CM009515.1.712 Q96ME1 FXL18_HUMAN 84.956 0.936798 0.884472 FBXL18 - F-box/LRR-repeat protein 18 - Homo sapiens (Human) - FBXL18 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Indicus|evm.model.CM009515.1.713 O15417 TNC18_HUMAN 82.276 0.696864 0.966981 TNRC18 - Trinucleotide repeat-containing gene 18 protein - Homo sapiens (Human) - TNRC18 gene cytosol, mitochondrion, nuclear membrane, nucleoplasm Indicus|evm.model.CM009515.1.714 Q7RTT9 S29A4_HUMAN 86.629 0.996183 0.988679 SLC29A4 - Equilibrative nucleoside transporter 4 - Homo sapiens (Human) - SLC29A4 gene Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia. Indicus|evm.model.CM009515.1.715 Q5ZHN3 WIPI2_CHICK 91.514 0.995423 1.00229 WIPI2 - WD repeat domain phosphoinositide-interacting protein 2 - Gallus gallus (Chicken) - WIPI2 gene Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Indicus|evm.model.CM009515.1.716 Q8R189 PAQRA_MOUSE 81.818 0.973684 0.923077 Mmd2 - Monocyte to macrophage differentiation factor 2 - Mus musculus (Mouse) - Mmd2 gene perinuclear region of cytoplasm, protein kinase activity, positive regulation of neuron differentiation, positive regulation of protein kinase activity, positive regulation of Ras protein signal transduction, regulation of protein localization Indicus|evm.model.CM009515.1.717 Q96JH8 RADIL_HUMAN 81.250 0.223392 0.795349 RADIL - Ras-associating and dilute domain-containing protein - Homo sapiens (Human) - RADIL gene Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. Indicus|evm.model.CM009515.1.718 O43299 AP5Z1_HUMAN 74.752 0.997525 1.00124 AP5Z1 - AP-5 complex subunit zeta-1 - Homo sapiens (Human) - AP5Z1 gene As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. Indicus|evm.model.CM009515.1.719 P42128 FOXK1_MOUSE 89.815 0.907692 0.81363 Foxk1 - Forkhead box protein K1 - Mus musculus (Mouse) - Foxk1 gene Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (PubMed:25402684, PubMed:29861159, PubMed:30700909). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:25402684, PubMed:29861159, PubMed:30700909). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (PubMed:30700909). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (PubMed:30700909). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (PubMed:30700909). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (PubMed:29861159). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (PubMed:25402684). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (PubMed:8007964, PubMed:9271401, PubMed:12446708, PubMed:22956541). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (PubMed:8007964, PubMed:9271401). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (PubMed:12446708, PubMed:22956541). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (PubMed:9271401, PubMed:22956541). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (PubMed:10792059). Represses myogenic differentiation by inhibiting MEFC activity (PubMed:22956541). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (By similarity). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (By similarity). Indicus|evm.model.CM009515.1.721 P85037 FOXK1_HUMAN 98.507 0.333333 0.270123 FOXK1 - Forkhead box protein K1 - Homo sapiens (Human) - FOXK1 gene Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Indicus|evm.model.CM009515.1.722 Q7Z5N4 SDK1_HUMAN 89.699 0.282132 1.00904 SDK1 - Protein sidekick-1 precursor - Homo sapiens (Human) - SDK1 gene Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. Indicus|evm.model.CM009515.1.724 Q7Z5N4 SDK1_HUMAN 73.585 0.163522 0.143696 SDK1 - Protein sidekick-1 precursor - Homo sapiens (Human) - SDK1 gene Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. Indicus|evm.model.CM009515.1.725 Q3UH53 SDK1_MOUSE 79.333 0.792553 0.0857273 Sdk1 - Protein sidekick-1 precursor - Mus musculus (Mouse) - Sdk1 gene Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. Indicus|evm.model.CM009515.1.729 Q9BXL7 CAR11_HUMAN 93.501 0.998268 1.00087 CARD11 - Caspase recruitment domain-containing protein 11 - Homo sapiens (Human) - CARD11 gene Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). Indicus|evm.model.CM009515.1.730 Q03113 GNA12_HUMAN 91.727 0.899654 0.75853 GNA12 - Guanine nucleotide-binding protein subunit alpha-12 - Homo sapiens (Human) - GNA12 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). Indicus|evm.model.CM009515.1.732 Q400G9 AMZ1_HUMAN 76.238 0.799358 1.251 AMZ1 - Archaemetzincin-1 - Homo sapiens (Human) - AMZ1 gene Probable zinc metalloprotease. Indicus|evm.model.CM009515.1.733 D2I4M3 BRAT1_AILME 76.914 0.969011 1.01944 BRAT1 - BRCA1-associated ATM activator 1 - Ailuropoda melanoleuca (Giant panda) - BRAT1 gene Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors. Indicus|evm.model.CM009515.1.734 Q6IPM2 IQCE_HUMAN 65.303 0.918742 1.09784 IQCE - IQ domain-containing protein E - Homo sapiens (Human) - IQCE gene Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). Indicus|evm.model.CM009515.1.735 Q9C0H2 TTYH3_HUMAN 95.435 0.659483 1.33078 TTYH3 - Protein tweety homolog 3 - Homo sapiens (Human) - TTYH3 gene Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. Indicus|evm.model.CM009515.1.736 Q2KJ92 LFNG_BOVIN 100.000 0.94822 0.813158 LFNG - Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe - Bos taurus (Bovine) - LFNG gene Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning. Indicus|evm.model.CM009515.1.738 Q9D1U0 GRIFN_MOUSE 79.464 0.552239 1.39583 Grifin - Grifin - Mus musculus (Mouse) - Grifin gene cytoplasm Indicus|evm.model.CM009515.1.739 Q99LL3 CHSTC_MOUSE 80.430 0.988095 1.00239 Chst12 - Carbohydrate sulfotransferase 12 - Mus musculus (Mouse) - Chst12 gene Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity). Indicus|evm.model.CM009515.1.741 Q2TAC6 KIF19_HUMAN 53.650 0.69913 1.1523 KIF19 - Kinesin-like protein KIF19 - Homo sapiens (Human) - KIF19 gene Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips. Indicus|evm.model.CM009515.1.742 P55884 EIF3B_HUMAN 95.634 0.820212 1.04545 EIF3B - Eukaryotic translation initiation factor 3 subunit B - Homo sapiens (Human) - EIF3B gene RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Indicus|evm.model.CM009515.1.743 Q2KHV6 SNX8_BOVIN 99.559 0.995604 0.991285 SNX8 - Sorting nexin-8 - Bos taurus (Bovine) - SNX8 gene May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity). Indicus|evm.model.CM009515.1.745 F1P963 8ODP_CANLF 87.821 0.45858 2.16667 NUDT1 - 7,8-dihydro-8-oxoguanine triphosphatase precursor - Canis lupus familiaris (Dog) - NUDT1 gene Antimutagenic. Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:29281266). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (By similarity). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). Indicus|evm.model.CM009515.1.746 Q9CPY0 MRM2_MOUSE 85.000 0.16422 4.43089 Mrm2 - rRNA methyltransferase 2, mitochondrial precursor - Mus musculus (Mouse) - Mrm2 gene S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Indicus|evm.model.CM009515.1.749 P0C7U0 ELFN1_HUMAN 88.477 0.380727 0.764493 ELFN1 - Protein ELFN1 precursor - Homo sapiens (Human) - ELFN1 gene Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Indicus|evm.model.CM009515.1.751 Q2NKS3 PSMG3_BOVIN 100.000 0.98374 1.0082 PSMG3 - Proteasome assembly chaperone 3 - Bos taurus (Bovine) - PSMG3 gene Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes. Indicus|evm.model.CM009515.1.752 Q1RMW2 T184A_BOVIN 99.517 0.995181 1.00242 TMEM184A - Transmembrane protein 184A - Bos taurus (Bovine) - TMEM184A gene Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity). Indicus|evm.model.CM009515.1.753 Q61827 MAFK_MOUSE 94.268 0.987342 1.01282 Mafk - Transcription factor MafK - Mus musculus (Mouse) - Mafk gene Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9240432). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (By similarity). Indicus|evm.model.CM009515.1.754 Q8N201 INT1_HUMAN 81.441 0.999054 0.965297 INTS1 - Integrator complex subunit 1 - Homo sapiens (Human) - INTS1 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Indicus|evm.model.CM009515.1.755 Q8IY33 MILK2_HUMAN 60.529 0.986425 0.977876 MICALL2 - MICAL-like protein 2 - Homo sapiens (Human) - MICALL2 gene Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Indicus|evm.model.CM009515.1.758 Q50D79 UNC4_DANRE 96.667 0.0634409 1.97872 uncx - Homeobox protein unc-4 homolog - Danio rerio (Zebrafish) - uncx gene Transcription factor involved in somitogenesis and neurogenesis. Indicus|evm.model.CM009515.1.759 Q8N6M9 ZFN2A_HUMAN 70.345 0.83237 1.1931 ZFAND2A - AN1-type zinc finger protein 2A - Homo sapiens (Human) - ZFAND2A gene Indicus|evm.model.CM009515.1.760 Q9BRJ6 CG050_HUMAN 68.718 0.825112 1.14948 C7orf50 - Uncharacterized protein C7orf50 - Homo sapiens (Human) - C7orf50 gene RNA binding Indicus|evm.model.CM009515.1.761 Q8TAV3 CP2W1_HUMAN 81.104 0.951417 1.00816 CYP2W1 - Cytochrome P450 2W1 precursor - Homo sapiens (Human) - CYP2W1 gene A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism (PubMed:22591743, PubMed:26936974). Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates (PubMed:26936974). Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) (PubMed:22591743). Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids (PubMed:26936974, PubMed:22591743). May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:20805301, PubMed:16551781, PubMed:24278521). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22591743, PubMed:26936974). Indicus|evm.model.CM009515.1.762 A8E4L1 COX19_BOVIN 100.000 0.977778 1.01124 COX19 - Cytochrome c oxidase assembly protein COX19 - Bos taurus (Bovine) - COX19 gene Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity). Indicus|evm.model.CM009515.1.763 O75689 ADAP1_HUMAN 88.889 0.883838 1.05882 ADAP1 - Arf-GAP with dual PH domain-containing protein 1 - Homo sapiens (Human) - ADAP1 gene GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Indicus|evm.model.CM009515.1.765 O94901 SUN1_HUMAN 81.655 0.816568 0.416256 SUN1 - SUN domain-containing protein 1 - Homo sapiens (Human) - SUN1 gene As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenenis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709). Indicus|evm.model.CM009515.1.766 Q0P5I8 GET4_BOVIN 100.000 0.989848 0.606154 GET4 - Golgi to ER traffic protein 4 homolog - Bos taurus (Bovine) - GET4 gene As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. Indicus|evm.model.CM009515.1.767 O94901 SUN1_HUMAN 71.689 0.361062 0.695813 SUN1 - SUN domain-containing protein 1 - Homo sapiens (Human) - SUN1 gene As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenenis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709). Indicus|evm.model.CM009515.1.768 B9EJR8 DAAF5_MOUSE 77.778 0.049505 0.828839 Dnaaf5 - Dynein axonemal assembly factor 5 - Mus musculus (Mouse) - Dnaaf5 gene Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. Indicus|evm.model.CM009515.1.769 Q5ZM91 KAP0_CHICK 76.190 0.405941 0.264398 PRKAR1A - cAMP-dependent protein kinase type I-alpha regulatory subunit - Gallus gallus (Chicken) - PRKAR1A gene cAMP-dependent protein kinase complex, cAMP-dependent protein kinase regulator activity, regulation of cAMP-mediated signaling, regulation of protein kinase A signaling Indicus|evm.model.CM009515.1.770 P12849 KAP1_MOUSE 100.000 0.218045 0.349081 Prkar1b - cAMP-dependent protein kinase type I-beta regulatory subunit - Mus musculus (Mouse) - Prkar1b gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Indicus|evm.model.CM009515.1.772 P31321 KAP1_HUMAN 97.009 0.803448 0.761155 PRKAR1B - cAMP-dependent protein kinase type I-beta regulatory subunit - Homo sapiens (Human) - PRKAR1B gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Indicus|evm.model.CM009515.1.773 Q2KJ15 PDGFA_BOVIN 92.473 0.66787 1.3128 PDGFA - Platelet-derived growth factor subunit A precursor - Bos taurus (Bovine) - PDGFA gene Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). Indicus|evm.model.CM009515.1.775 A0A1W2PRP0 FOXL3_HUMAN 72.152 0.990868 0.939914 FOXL3 - Forkhead box protein L3 - Homo sapiens (Human) - FOXL3 gene Probable transcriptional regulator. Indicus|evm.model.CM009515.1.776 Q8IXL6 FA20C_HUMAN 89.021 0.419517 1.70205 FAM20C - Extracellular serine/threonine protein kinase FAM20C precursor - Homo sapiens (Human) - FAM20C gene Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039). Indicus|evm.model.CM009515.1.777 Q0EEE2 PTHD3_MOUSE 69.140 0.992505 1.03091 Ptchd3 - Patched domain-containing protein 3 - Mus musculus (Mouse) - Ptchd3 gene May play a role in sperm development or sperm function. Indicus|evm.model.CM009516.1.2 Q9UPS8 ANR26_HUMAN 56.173 0.756757 0.0865497 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009516.1.3 Q9BQI4 CCDC3_HUMAN 62.434 0.935135 0.685185 CCDC3 - Coiled-coil domain-containing protein 3 precursor - Homo sapiens (Human) - CCDC3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity). Indicus|evm.model.CM009516.1.4 P41224 TEF_RAT 66.667 0.44186 0.285714 Tef - Thyrotroph embryonic factor - Rattus norvegicus (Rat) - Tef gene Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'. Indicus|evm.model.CM009516.1.7 O14815 CAN9_HUMAN 76.087 0.330882 0.197101 CAPN9 - Calpain-9 - Homo sapiens (Human) - CAPN9 gene Calcium-regulated non-lysosomal thiol-protease. Indicus|evm.model.CM009516.1.8 D3ZDK2 UB2D1_RAT 100.000 0.986486 1.0068 Ube2d1 - Ubiquitin-conjugating enzyme E2 D1 - Rattus norvegicus (Rat) - Ube2d1 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 (By similarity). Mediates ubiquitination of PEX5. Indicus|evm.model.CM009516.1.9 P16116 ALDR_BOVIN 98.095 0.990536 1.00635 AKR1B1 - Aldo-keto reductase family 1 member B1 - Bos taurus (Bovine) - AKR1B1 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Indicus|evm.model.CM009516.1.10 Q3ZBU2 CISD1_BOVIN 100.000 0.981308 1.00943 CISD1 - CDGSH iron-sulfur domain-containing protein 1 - Bos taurus (Bovine) - CISD1 gene Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions (By similarity). Indicus|evm.model.CM009516.1.11 Q8NFU5 IPMK_HUMAN 91.827 0.995204 1.0024 IPMK - Inositol polyphosphate multikinase - Homo sapiens (Human) - IPMK gene Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:30420721, PubMed:28882892). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). Indicus|evm.model.CM009516.1.13 Q93008 USP9X_HUMAN 98.361 0.937984 0.050509 USP9X - Probable ubiquitin carboxyl-terminal hydrolase FAF-X - Homo sapiens (Human) - USP9X gene Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed:16322459, PubMed:18254724, PubMed:19135894, PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed:29626158). Indicus|evm.model.CM009516.1.17 Q2TBH8 ZWINT_BOVIN 99.301 0.993031 1.0035 ZWINT - ZW10 interactor - Bos taurus (Bovine) - ZWINT gene Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity). Indicus|evm.model.CM009516.1.18 Q13309 SKP2_HUMAN 89.224 0.891892 0.610849 SKP2 - S-phase kinase-associated protein 2 - Homo sapiens (Human) - SKP2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Indicus|evm.model.CM009516.1.19 Q7Z434 MAVS_HUMAN 46.789 0.923077 0.192593 MAVS - Mitochondrial antiviral-signaling protein - Homo sapiens (Human) - MAVS gene Required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:20127681, PubMed:21170385). Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:25636800, PubMed:20127681, PubMed:21170385, PubMed:20628368). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Indicus|evm.model.CM009516.1.23 Q0ZM14 PCD15_CHICK 72.492 0.289474 0.560295 Pcdh15 - Protocadherin-15 precursor - Gallus gallus (Chicken) - Pcdh15 gene Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function (By similarity). Indicus|evm.model.CM009516.1.25 O02659 MBL2_BOVIN 99.598 0.992 1.00402 MBL - Mannose-binding protein C precursor - Bos taurus (Bovine) - MBL gene Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). Indicus|evm.model.CM009516.1.27 O94907 DKK1_HUMAN 83.951 0.258065 1.16541 DKK1 - Dickkopf-related protein 1 precursor - Homo sapiens (Human) - DKK1 gene Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity). Indicus|evm.model.CM009516.1.28 Q13976 KGP1_HUMAN 99.394 0.976261 0.502235 PRKG1 - cGMP-dependent protein kinase 1 - Homo sapiens (Human) - PRKG1 gene Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. Indicus|evm.model.CM009516.1.31 Q9H0L4 CSTFT_HUMAN 89.857 0.99679 1.01136 CSTF2T - Cleavage stimulation factor subunit 2 tau variant - Homo sapiens (Human) - CSTF2T gene May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). Indicus|evm.model.CM009516.1.33 P00516 KGP1_BOVIN 100.000 0.714286 0.114754 PRKG1 - cGMP-dependent protein kinase 1 - Bos taurus (Bovine) - PRKG1 gene Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle (By similarity). Indicus|evm.model.CM009516.1.35 O77676 KGP1_RABIT 100.000 0.833333 0.125186 PRKG1 - cGMP-dependent protein kinase 1 - Oryctolagus cuniculus (Rabbit) - PRKG1 gene Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle (By similarity). Indicus|evm.model.CM009516.1.36 Q9NQ94 A1CF_HUMAN 95.966 0.996644 1.00337 A1CF - APOBEC1 complementation factor - Homo sapiens (Human) - A1CF gene Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. Indicus|evm.model.CM009516.1.37 Q9NR71 ASAH2_HUMAN 82.730 0.806998 1.1359 ASAH2 - Neutral ceramidase - Homo sapiens (Human) - ASAH2 gene Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10781606, PubMed:16229686, PubMed:26190575). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:15946935, PubMed:19345744, PubMed:24798654). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:11278489, PubMed:17475390). Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:16061940). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity). This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (By similarity). Indicus|evm.model.CM009516.1.38 A0AAS4 SMS1_PIG 96.852 0.995169 0.990431 SGMS1 - Phosphatidylcholine:ceramide cholinephosphotransferase 1 - Sus scrofa (Pig) - SGMS1 gene Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Does not use free phosphorylcholine or CDP-choline as donor. Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1. Indicus|evm.model.CM009516.1.42 Q9UNW1 MINP1_HUMAN 79.055 0.995595 0.932238 MINPP1 - Multiple inositol polyphosphate phosphatase 1 precursor - Homo sapiens (Human) - MINPP1 gene Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity). Indicus|evm.model.CM009516.1.43 O95340 PAPS2_HUMAN 93.110 0.974138 0.944625 PAPSS2 - Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 - Homo sapiens (Human) - PAPSS2 gene Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have an important role in skeletogenesis during postnatal growth (By similarity). Indicus|evm.model.CM009516.1.44 F6QV99 ATAD1_BOVIN 100.000 0.994475 1.00277 ATAD1 - Outer mitochondrial transmembrane helix translocase - Bos taurus (Bovine) - ATAD1 gene Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). Indicus|evm.model.CM009516.1.45 P60484 PTEN_HUMAN 99.752 0.99505 1.00248 PTEN - Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN - Homo sapiens (Human) - PTEN gene Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226, PubMed:16824732). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. Indicus|evm.model.CM009516.1.46 Q5VYX0 RNLS_HUMAN 84.503 0.994169 1.00292 RNLS - Renalase precursor - Homo sapiens (Human) - RNLS gene Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. Indicus|evm.model.CM009516.1.47 Q5W064 LIPJ_HUMAN 81.644 0.912281 1.09016 LIPJ - Lipase member J - Homo sapiens (Human) - LIPJ gene intracellular membrane-bounded organelle Indicus|evm.model.CM009516.1.48 P15927 RFA2_HUMAN 89.630 0.99262 1.0037 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Indicus|evm.model.CM009516.1.49 Q29458 LIPG_BOVIN 99.435 0.98324 0.450882 LIPF - Gastric triacylglycerol lipase precursor - Bos taurus (Bovine) - LIPF gene Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:8615791). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (By similarity). Indicus|evm.model.CM009516.1.50 Q5VXJ0 LIPK_HUMAN 84.635 0.994962 0.994987 LIPK - Lipase member K precursor - Homo sapiens (Human) - LIPK gene Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. Indicus|evm.model.CM009516.1.51 Q5VXI9 LIPN_HUMAN 81.566 0.992462 1 LIPN - Lipase member N precursor - Homo sapiens (Human) - LIPN gene Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. Indicus|evm.model.CM009516.1.52 Q5VYY2 LIPM_HUMAN 87.943 0.995283 1.00236 LIPM - Lipase member M precursor - Homo sapiens (Human) - LIPM gene Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. Indicus|evm.model.CM009516.1.53 Q5VYY1 ANR22_HUMAN 90.526 0.984375 1.00524 ANKRD22 - Ankyrin repeat domain-containing protein 22 - Homo sapiens (Human) - ANKRD22 gene Indicus|evm.model.CM009516.1.54 Q96FJ0 STALP_HUMAN 92.661 0.995423 1.00229 STAMBPL1 - AMSH-like protease - Homo sapiens (Human) - STAMBPL1 gene Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Indicus|evm.model.CM009516.1.55 P62738 ACTA_RAT 100.000 0.994709 1.00265 Acta2 - Actin, aortic smooth muscle precursor - Rattus norvegicus (Rat) - Acta2 gene Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Indicus|evm.model.CM009516.1.56 P51867 TNR6_BOVIN 99.690 0.993827 1.0031 FAS - Tumor necrosis factor receptor superfamily member 6 precursor - Bos taurus (Bovine) - FAS gene Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). Indicus|evm.model.CM009516.1.57 Q4G1G8 CH25H_PIG 86.296 0.99262 1.0037 CH25H - Cholesterol 25-hydroxylase - Sus scrofa (Pig) - CH25H gene Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. Indicus|evm.model.CM009516.1.58 Q4R4S5 LICH_MACFA 82.456 0.995 1.00251 LIPA - Lysosomal acid lipase/cholesteryl ester hydrolase precursor - Macaca fascicularis (Crab-eating macaque) - LIPA gene Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. Indicus|evm.model.CM009516.1.59 P09913 IFIT2_HUMAN 74.034 0.73906 1.3072 IFIT2 - Interferon-induced protein with tetratricopeptide repeats 2 - Homo sapiens (Human) - IFIT2 gene IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. Indicus|evm.model.CM009516.1.60 O14879 IFIT3_HUMAN 71.546 0.989712 0.991837 IFIT3 - Interferon-induced protein with tetratricopeptide repeats 3 - Homo sapiens (Human) - IFIT3 gene IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. Indicus|evm.model.CM009516.1.61 Q4R5F5 IFIT1_MACFA 67.511 0.985386 1.00209 IFIT1 - Interferon-induced protein with tetratricopeptide repeats 1 - Macaca fascicularis (Crab-eating macaque) - IFIT1 gene Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism) (By similarity). Indicus|evm.model.CM009516.1.62 Q13325 IFIT5_HUMAN 92.531 0.707353 1.41079 IFIT5 - Interferon-induced protein with tetratricopeptide repeats 5 - Homo sapiens (Human) - IFIT5 gene Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375). Indicus|evm.model.CM009516.1.63 Q6ZSM3 MOT12_HUMAN 91.152 0.995893 0.943798 SLC16A12 - Monocarboxylate transporter 12 - Homo sapiens (Human) - SLC16A12 gene Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane. Indicus|evm.model.CM009516.1.64 Q8TE04 PANK1_HUMAN 91.304 0.996622 0.989967 PANK1 - Pantothenate kinase 1 - Homo sapiens (Human) - PANK1 gene Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Indicus|evm.model.CM009516.1.65 Q96Q89 KI20B_HUMAN 81.793 0.994556 1.00934 KIF20B - Kinesin-like protein KIF20B - Homo sapiens (Human) - KIF20B gene Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). Indicus|evm.model.CM009516.1.69 P56602 PPOX_BOVIN 88.235 0.611399 0.404612 PPOX - Protoporphyrinogen oxidase - Bos taurus (Bovine) - PPOX gene Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Indicus|evm.model.CM009516.1.70 Q6U7Q0 ZN322_HUMAN 93.077 0.984733 0.325871 ZNF322 - Zinc finger protein 322 - Homo sapiens (Human) - ZNF322 gene Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). Indicus|evm.model.CM009516.1.71 P34969 5HT7R_HUMAN 94.037 0.995413 0.91023 HTR7 - 5-hydroxytryptamine receptor 7 - Homo sapiens (Human) - HTR7 gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Indicus|evm.model.CM009516.1.72 Q3SZ21 RPP30_BOVIN 100.000 0.992565 1.00373 RPP30 - Ribonuclease P protein subunit p30 - Bos taurus (Bovine) - RPP30 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Indicus|evm.model.CM009516.1.73 Q3ZBX7 ANKR1_BOVIN 100.000 0.99375 1.00313 ANKRD1 - Ankyrin repeat domain-containing protein 1 - Bos taurus (Bovine) - ANKRD1 gene May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). Indicus|evm.model.CM009516.1.74 Q8BVU5 NUDT9_MOUSE 75.714 0.588983 0.674286 Nudt9 - ADP-ribose pyrophosphatase, mitochondrial precursor - Mus musculus (Mouse) - Nudt9 gene Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. Indicus|evm.model.CM009516.1.75 A0JN86 PCGF5_BOVIN 99.609 0.992218 1.00784 PCGF5 - Polycomb group RING finger protein 5 - Bos taurus (Bovine) - PCGF5 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). Indicus|evm.model.CM009516.1.76 Q5RD78 HECD2_PONAB 92.397 0.915976 1.08892 HECTD2 - Probable E3 ubiquitin-protein ligase HECTD2 - Pongo abelii (Sumatran orangutan) - HECTD2 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Indicus|evm.model.CM009516.1.77 Q0VCR4 PPR3C_BOVIN 100.000 0.993631 0.987421 PPP1R3C - Protein phosphatase 1 regulatory subunit 3C - Bos taurus (Bovine) - PPP1R3C gene Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types (By similarity). Indicus|evm.model.CM009516.1.78 Q3UES3 TNKS2_MOUSE 91.710 0.863492 1.08062 Tnks2 - Poly [ADP-ribose] polymerase tankyrase-2 - Mus musculus (Mouse) - Tnks2 gene Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity. Indicus|evm.model.CM009516.1.79 Q8TAT2 FGFP3_HUMAN 72.845 0.895349 1 FGFBP3 - Fibroblast growth factor-binding protein 3 precursor - Homo sapiens (Human) - FGFBP3 gene Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability. Indicus|evm.model.CM009516.1.80 O14981 BTAF1_HUMAN 95.403 0.998918 1 BTAF1 - TATA-binding protein-associated factor 172 - Homo sapiens (Human) - BTAF1 gene Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner. Indicus|evm.model.CM009516.1.81 Q8NE35 CPEB3_HUMAN 92.938 0.997076 0.979943 CPEB3 - Cytoplasmic polyadenylation element-binding protein 3 - Homo sapiens (Human) - CPEB3 gene Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). Indicus|evm.model.CM009516.1.82 Q3KNM2 MARH5_MOUSE 100.000 0.988571 0.629496 Marchf5 - E3 ubiquitin-protein ligase MARCHF5 - Mus musculus (Mouse) - Marchf5 gene Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. Indicus|evm.model.CM009516.1.83 Q24K02 IDE_BOVIN 100.000 0.998039 1.00098 IDE - Insulin-degrading enzyme - Bos taurus (Bovine) - IDE gene Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (By similarity). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (By similarity). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP. Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (By similarity). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (By similarity). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (By similarity). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I (By similarity). Indicus|evm.model.CM009516.1.84 P52732 KIF11_HUMAN 85.701 0.998106 1 KIF11 - Kinesin-like protein KIF11 - Homo sapiens (Human) - KIF11 gene Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). Indicus|evm.model.CM009516.1.85 P46405 RS12_PIG 91.667 0.940594 0.765152 RPS12 - 40S ribosomal protein S12 - Sus scrofa (Pig) - RPS12 gene cytosolic small ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009516.1.86 O19110 TSPY1_BOVIN 57.692 0.819149 0.29653 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009516.1.87 Q03014 HHEX_HUMAN 94.485 0.992647 1.00741 HHEX - Hematopoietically-expressed homeobox protein HHEX - Homo sapiens (Human) - HHEX gene Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). May play a role in hematopoietic differentiation (PubMed:8096636). Indicus|evm.model.CM009516.1.88 E2R766 EXOC6_CANLF 95.203 0.997543 1.0137 EXOC6 - Exocyst complex component 6 - Canis lupus familiaris (Dog) - EXOC6 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (By similarity). Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Indicus|evm.model.CM009516.1.89 Q6V0L0 CP26C_HUMAN 89.231 0.990458 1.00383 CYP26C1 - Cytochrome P450 26C1 - Homo sapiens (Human) - CYP26C1 gene Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate). Indicus|evm.model.CM009516.1.90 O55127 CP26A_MOUSE 94.567 0.995984 1.00201 Cyp26a1 - Cytochrome P450 26A1 - Mus musculus (Mouse) - Cyp26a1 gene A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18 (PubMed:9250660, PubMed:9442090). Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers. May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (By similarity). Indicus|evm.model.CM009516.1.91 Q9NZM1 MYOF_HUMAN 93.207 0.99903 1 MYOF - Myoferlin - Homo sapiens (Human) - MYOF gene Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). Indicus|evm.model.CM009516.1.92 Q53EZ4 CEP55_HUMAN 85.345 0.99569 1 CEP55 - Centrosomal protein of 55 kDa - Homo sapiens (Human) - CEP55 gene Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). Indicus|evm.model.CM009516.1.93 C8YUV0 FFAR4_MACFA 85.596 0.994475 1.00277 FFAR4 - Free fatty acid receptor 4 - Macaca fascicularis (Crab-eating macaque) - FFAR4 gene G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways. LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (By similarity). In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation. Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry. Induces differentiation of brown and beige adipocytes probably via autocrine and endocrine functions of FGF21 hormone. Contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue. Activates brown adipocytes by initiating intracellular calcium signaling leading to mitochondrial depolarization and fission, and overall increased mitochondrial respiration. Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass. Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins. In response to dietary fats regulates hormone secretion and appetite. Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels. Negatively regulates glucose-induced SST secretion in pancreatic delta cells. Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone. In taste buds, contributes to sensing of dietary fatty acids by the gustatory system. During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (By similarity). Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (By similarity). In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (By similarity). Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of proinflammatory cytokine release (By similarity). Mediates LCFAs anti-apoptotic effects (By similarity). Indicus|evm.model.CM009516.1.94 P18902 RET4_BOVIN 100.000 0.90099 1.10383 RBP4 - Retinol-binding protein 4 - Bos taurus (Bovine) - RBP4 gene Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Indicus|evm.model.CM009516.1.95 P16586 PDE6C_BOVIN 99.532 0.997664 1.00117 PDE6C - Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' precursor - Bos taurus (Bovine) - PDE6C gene As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. Indicus|evm.model.CM009516.1.96 Q70Z53 F10C1_HUMAN 91.722 0.993399 0.961905 FRA10AC1 - Protein FRA10AC1 - Homo sapiens (Human) - FRA10AC1 gene phosphatase activity, dephosphorylation Indicus|evm.model.CM009516.1.97 Q5E9T6 LGI1_BOVIN 100.000 0.664804 0.335835 LGI1 - Leucine-rich glioma-inactivated protein 1 precursor - Bos taurus (Bovine) - LGI1 gene Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). Indicus|evm.model.CM009516.1.98 Q5E9T6 LGI1_BOVIN 96.011 0.824645 0.791745 LGI1 - Leucine-rich glioma-inactivated protein 1 precursor - Bos taurus (Bovine) - LGI1 gene Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). Indicus|evm.model.CM009516.1.99 Q2M3R5 S35G1_HUMAN 75.342 0.994536 1.00274 SLC35G1 - Solute carrier family 35 member G1 - Homo sapiens (Human) - SLC35G1 gene May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell. Indicus|evm.model.CM009516.1.100 Q9P212 PLCE1_HUMAN 76.675 0.915525 0.190269 PLCE1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 - Homo sapiens (Human) - PLCE1 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). Indicus|evm.model.CM009516.1.101 Q9P212 PLCE1_HUMAN 91.746 0.998946 0.824066 PLCE1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 - Homo sapiens (Human) - PLCE1 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). Indicus|evm.model.CM009516.1.102 Q8WTT2 NOC3L_HUMAN 92.991 0.99625 1 NOC3L - Nucleolar complex protein 3 homolog - Homo sapiens (Human) - NOC3L gene May be required for adipogenesis. Indicus|evm.model.CM009516.1.103 Q9NRZ9 HELLS_HUMAN 93.099 0.519948 1.82458 HELLS - Lymphoid-specific helicase - Homo sapiens (Human) - HELLS gene Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). Indicus|evm.model.CM009516.1.104 P33260 CP2CI_HUMAN 80.415 0.592339 1.49184 CYP2C18 - Cytochrome P450 2C18 precursor - Homo sapiens (Human) - CYP2C18 gene A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.CM009516.1.105 P33260 CP2CI_HUMAN 78.252 0.995943 1.00612 CYP2C18 - Cytochrome P450 2C18 precursor - Homo sapiens (Human) - CYP2C18 gene A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.CM009516.1.106 P33263 CP2CQ_MESAU 74.725 0.967742 0.189796 CYP2C26 - Cytochrome P450 2C26 - Mesocricetus auratus (Golden hamster) - CYP2C26 gene Catalyzes the hydroxylation of tolbutamide and the N-demethylation of aminopyrine and benzphetamine. Indicus|evm.model.CM009516.1.107 P11712 CP2C9_HUMAN 78.981 0.95723 1.00204 CYP2C9 - Cytochrome P450 2C9 - Homo sapiens (Human) - CYP2C9 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:7574697, PubMed:15766564, PubMed:19965576, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9866708, PubMed:9435160). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031). Indicus|evm.model.CM009516.1.108 P33262 CP2CK_MACFA 88.525 0.84507 0.144898 CYP2C20 - Cytochrome P450 2C20 - Macaca fascicularis (Crab-eating macaque) - CYP2C20 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Indicus|evm.model.CM009516.1.109 P33260 CP2CI_HUMAN 70.000 0.995465 0.9 CYP2C18 - Cytochrome P450 2C18 precursor - Homo sapiens (Human) - CYP2C18 gene A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.CM009516.1.110 P56594 CP2CL_CANLF 79.118 0.325511 2.71253 CYP2C21 - Cytochrome P450 2C21 - Canis lupus familiaris (Dog) - CYP2C21 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Showed testosterone hydrolase activity. Indicus|evm.model.CM009516.1.111 Q5E9E1 PDLI1_BOVIN 99.695 0.993921 1.00305 PDLIM1 - PDZ and LIM domain protein 1 - Bos taurus (Bovine) - PDLIM1 gene Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). Indicus|evm.model.CM009516.1.112 Q9BX66 SRBS1_HUMAN 97.500 0.0956416 0.639319 SORBS1 - Sorbin and SH3 domain-containing protein 1 - Homo sapiens (Human) - SORBS1 gene Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). Indicus|evm.model.CM009516.1.113 Q5R4M8 P5CS_PONAB 97.484 0.997487 1.00126 ALDH18A1 - Delta-1-pyrroline-5-carboxylate synthase - Pongo abelii (Sumatran orangutan) - ALDH18A1 gene Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. Indicus|evm.model.CM009516.1.114 Q6NUS6 TECT3_HUMAN 80.405 0.971667 0.988468 TCTN3 - Tectonic-3 precursor - Homo sapiens (Human) - TCTN3 gene Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway. Indicus|evm.model.CM009516.1.115 O18956 ENTP1_BOVIN 98.821 0.965779 1.02534 ENTPD1 - Ectonucleoside triphosphate diphosphohydrolase 1 - Bos taurus (Bovine) - ENTPD1 gene In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. Indicus|evm.model.CM009516.1.116 Q6DHV5 C2D2B_HUMAN 80.028 0.989503 0.994433 CC2D2B - Protein CC2D2B - Homo sapiens (Human) - CC2D2B gene Indicus|evm.model.CM009516.1.117 Q5T5M9 CCNJ_HUMAN 93.995 0.994792 1.03226 CCNJ - Cyclin-J - Homo sapiens (Human) - CCNJ gene centrosome, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus, cyclin-dependent protein serine/threonine kinase regulator activity, mitotic cell cycle phase transition, regulation of cyclin-dependent protein serine/threonine kinase activity Indicus|evm.model.CM009516.1.118 Q6AHZ1 Z518A_HUMAN 78.495 0.998651 1 ZNF518A - Zinc finger protein 518A - Homo sapiens (Human) - ZNF518A gene Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes. Indicus|evm.model.CM009516.1.119 Q8WV28 BLNK_HUMAN 88.235 0.995652 1.00877 BLNK - B-cell linker protein - Homo sapiens (Human) - BLNK gene Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. Indicus|evm.model.CM009516.1.120 P06526 TDT_BOVIN 100.000 0.996078 1.00196 DNTT - DNA nucleotidylexotransferase - Bos taurus (Bovine) - DNTT gene Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator (PubMed:3755527). One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. Indicus|evm.model.CM009516.1.121 Q29102 OPALI_PIG 85.915 0.986014 1.00704 OPALIN - Opalin - Sus scrofa (Pig) - OPALIN gene Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation. Indicus|evm.model.CM009516.1.122 Q9Y6L7 TLL2_HUMAN 87.745 0.997936 0.95468 TLL2 - Tolloid-like protein 2 precursor - Homo sapiens (Human) - TLL2 gene Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Indicus|evm.model.CM009516.1.123 Q9ET30 TM9S3_MOUSE 98.754 0.957338 0.998296 Tm9sf3 - Transmembrane 9 superfamily member 3 precursor - Mus musculus (Mouse) - Tm9sf3 gene membrane, protein localization to membrane Indicus|evm.model.CM009516.1.124 Q6ZUJ8 BCAP_HUMAN 90.447 0.997516 1 PIK3AP1 - Phosphoinositide 3-kinase adapter protein 1 - Homo sapiens (Human) - PIK3AP1 gene Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. Indicus|evm.model.CM009516.1.125 Q96JN0 LCOR_HUMAN 99.307 0.829175 1.20323 LCOR - Ligand-dependent corepressor - Homo sapiens (Human) - LCOR gene May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. Indicus|evm.model.CM009516.1.127 O75093 SLIT1_HUMAN 94.003 0.998697 1.00065 SLIT1 - Slit homolog 1 protein precursor - Homo sapiens (Human) - SLIT1 gene Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Indicus|evm.model.CM009516.1.128 Q14CB8 RHG19_HUMAN 92.683 0.995943 0.997976 ARHGAP19 - Rho GTPase-activating protein 19 - Homo sapiens (Human) - ARHGAP19 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009516.1.129 Q92837 FRAT1_HUMAN 81.071 0.992754 0.989247 FRAT1 - Proto-oncogene FRAT1 - Homo sapiens (Human) - FRAT1 gene Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. Indicus|evm.model.CM009516.1.130 O75474 FRAT2_HUMAN 79.741 0.986957 0.987124 FRAT2 - GSK-3-binding protein FRAT2 - Homo sapiens (Human) - FRAT2 gene Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. Indicus|evm.model.CM009516.1.131 Q5JTH9 RRP12_HUMAN 90.776 0.998459 1.00077 RRP12 - RRP12-like protein - Homo sapiens (Human) - RRP12 gene cytosol, intracellular membrane-bounded organelle, nucleolus, plasma membrane, RNA binding, rRNA processing Indicus|evm.model.CM009516.1.132 Q3SZ62 PGAM1_BOVIN 100.000 0.992157 1.00394 PGAM1 - Phosphoglycerate mutase 1 - Bos taurus (Bovine) - PGAM1 gene Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. Indicus|evm.model.CM009516.1.133 Q9DAA6 EXOS1_MOUSE 96.923 0.779116 1.27692 Exosc1 - Exosome complex component CSL4 - Mus musculus (Mouse) - Exosc1 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8 (By similarity). Indicus|evm.model.CM009516.1.134 Q58CU4 ZDH16_BOVIN 100.000 0.994709 1.00265 ZDHHC16 - Palmitoyltransferase ZDHHC16 - Bos taurus (Bovine) - ZDHHC16 gene Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (By similarity). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). Indicus|evm.model.CM009516.1.135 E1BP36 MMS19_BOVIN 99.806 0.998058 1 MMS19 - MMS19 nucleotide excision repair protein homolog - Bos taurus (Bovine) - MMS19 gene Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As a CIA complex component and in collaboration with CIAO1 and CIAO2, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. Indicus|evm.model.CM009516.1.137 Q3ZBQ1 UBTD1_BOVIN 100.000 0.944186 0.947137 UBTD1 - Ubiquitin domain-containing protein 1 - Bos taurus (Bovine) - UBTD1 gene May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2. Indicus|evm.model.CM009516.1.138 Q9GZV1 ANKR2_HUMAN 89.970 0.993939 0.916667 ANKRD2 - Ankyrin repeat domain-containing protein 2 - Homo sapiens (Human) - ANKRD2 gene Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. Indicus|evm.model.CM009516.1.139 Q0P5I5 HOGA1_BOVIN 100.000 0.993902 1.00306 HOGA1 - 4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor - Bos taurus (Bovine) - HOGA1 gene Catalyzes the final step in the metabolic pathway of hydroxyproline. Indicus|evm.model.CM009516.1.140 Q0VD26 MORN4_BOVIN 100.000 0.986395 1.00685 MORN4 - MORN repeat-containing protein 4 - Bos taurus (Bovine) - MORN4 gene Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. Indicus|evm.model.CM009516.1.141 Q9BTU6 P4K2A_HUMAN 97.912 0.995833 1.00209 PI4K2A - Phosphatidylinositol 4-kinase type 2-alpha - Homo sapiens (Human) - PI4K2A gene Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Indicus|evm.model.CM009516.1.142 Q3SZR0 AVPI1_BOVIN 100.000 0.986207 1.00694 AVPI1 - Arginine vasopressin-induced protein 1 - Bos taurus (Bovine) - AVPI1 gene May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. Indicus|evm.model.CM009516.1.143 Q7TQJ1 MALD1_MOUSE 87.879 0.808642 0.936416 Marveld1 - MARVEL domain-containing protein 1 - Mus musculus (Mouse) - Marveld1 gene Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration. Indicus|evm.model.CM009516.1.144 Q5BIM5 ZFY27_BOVIN 99.752 0.980535 1.01733 ZFYVE27 - Protrudin - Bos taurus (Bovine) - ZFYVE27 gene Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner. Indicus|evm.model.CM009516.1.145 Q9XSC1 SFRP5_BOVIN 100.000 0.993671 1.00317 SFRP5 - Secreted frizzled-related protein 5 precursor - Bos taurus (Bovine) - SFRP5 gene Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps other, cells in the retina. Inhibits Wnt8 signaling, in vitro. Indicus|evm.model.CM009516.1.146 Q2TAP0 GOG7B_HUMAN 98.171 0.730942 1.33533 GOLGA7B - Golgin subfamily A member 7B - Homo sapiens (Human) - GOLGA7B gene May be involved in protein transport from Golgi to cell surface. Indicus|evm.model.CM009516.1.147 Q9NQ79 CRAC1_HUMAN 96.296 0.994723 0.573374 CRTAC1 - Cartilage acidic protein 1 precursor - Homo sapiens (Human) - CRTAC1 gene extracellular exosome Indicus|evm.model.CM009516.1.148 Q7Z5L2 R3HCL_HUMAN 70.287 0.997459 0.993687 R3HCC1L - Coiled-coil domain-containing protein R3HCC1L - Homo sapiens (Human) - R3HCC1L gene Indicus|evm.model.CM009516.1.149 Q8MJ24 LOXL4_BOVIN 100.000 0.996226 0.700132 LOXL4 - Lysyl oxidase homolog 4 precursor - Bos taurus (Bovine) - LOXL4 gene May modulate the formation of a collagenous extracellular matrix. Indicus|evm.model.CM009516.1.150 Q8MJ24 LOXL4_BOVIN 99.556 0.807971 0.364597 LOXL4 - Lysyl oxidase homolog 4 precursor - Bos taurus (Bovine) - LOXL4 gene May modulate the formation of a collagenous extracellular matrix. Indicus|evm.model.CM009516.1.151 Q3MHH6 PYRD2_BOVIN 99.656 0.996564 1.00172 PYROXD2 - Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 - Bos taurus (Bovine) - PYROXD2 gene Probable oxidoreductase that may play a role as regulator of mitochondrial function. Indicus|evm.model.CM009516.1.152 Q92902 HPS1_HUMAN 82.793 0.95283 1.06 HPS1 - Hermansky-Pudlak syndrome 1 protein - Homo sapiens (Human) - HPS1 gene Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991). Indicus|evm.model.CM009516.1.153 Q8WWQ2 HPSE2_HUMAN 99.742 0.994859 0.657095 HPSE2 - Inactive heparanase-2 precursor - Homo sapiens (Human) - HPSE2 gene Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). Indicus|evm.model.CM009516.1.155 Q9NRU3 CNNM1_HUMAN 92.308 0.990635 1.01052 CNNM1 - Metal transporter CNNM1 - Homo sapiens (Human) - CNNM1 gene Probable metal transporter. Indicus|evm.model.CM009516.1.156 P33097 AATC_BOVIN 100.000 0.995169 1.00242 GOT1 - Aspartate aminotransferase, cytoplasmic - Bos taurus (Bovine) - GOT1 gene Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). Indicus|evm.model.CM009516.1.157 Q8TAU0 NKX23_HUMAN 91.826 0.994565 1.01099 NKX2-3 - Homeobox protein Nkx-2.3 - Homo sapiens (Human) - NKX2-3 gene Transcription factor. Indicus|evm.model.CM009516.1.158 Q96A46 MFRN2_HUMAN 98.352 0.994521 1.00275 SLC25A28 - Mitoferrin-2 - Homo sapiens (Human) - SLC25A28 gene Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). Indicus|evm.model.CM009516.1.160 Q9NQZ7 ENTP7_HUMAN 86.280 0.996956 1.08775 ENTPD7 - Ectonucleoside triphosphate diphosphohydrolase 7 - Homo sapiens (Human) - ENTPD7 gene Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Preferentially hydrolyzes nucleoside 5'-triphosphates, with substrate preference for UTP > GTP > CTP. Hydrolyzes ATP and nucleoside diphosphates only to a minor extent. Indicus|evm.model.CM009516.1.161 Q08DG6 COX15_BOVIN 99.758 0.995169 1.00242 COX15 - Cytochrome c oxidase assembly protein COX15 homolog - Bos taurus (Bovine) - COX15 gene May be involved in the biosynthesis of heme A. Indicus|evm.model.CM009516.1.162 Q9NTM9 CUTC_HUMAN 95.971 0.992701 1.00366 CUTC - Copper homeostasis protein cutC homolog - Homo sapiens (Human) - CUTC gene May play a role in copper homeostasis. Can bind one Cu(1+) per subunit. Indicus|evm.model.CM009516.1.163 Q92887 MRP2_HUMAN 79.417 0.998666 0.970227 ABCC2 - ATP-binding cassette sub-family C member 2 - Homo sapiens (Human) - ABCC2 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transport various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505). Indicus|evm.model.CM009516.1.164 Q6XZF7 DNMBP_HUMAN 90.832 0.679901 0.766646 DNMBP - Dynamin-binding protein - Homo sapiens (Human) - DNMBP gene Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). Indicus|evm.model.CM009516.1.165 Q6XZF7 DNMBP_HUMAN 76.943 0.920925 0.521243 DNMBP - Dynamin-binding protein - Homo sapiens (Human) - DNMBP gene Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). Indicus|evm.model.CM009516.1.167 Q2KJ83 CBPN_BOVIN 99.567 0.99568 1.00216 CPN1 - Carboxypeptidase N catalytic chain precursor - Bos taurus (Bovine) - CPN1 gene Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Indicus|evm.model.CM009516.1.168 P24470 CP2CN_RAT 74.141 0.995968 1.00405 Cyp2c23 - Cytochrome P450 2C23 - Rattus norvegicus (Rat) - Cyp2c23 gene A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonic acid (ARA, C20:4(n-6)) primarily to stereospecific products 8R,9S-, 11R,12S-, and 14S,15R-EET (PubMed:8246128, PubMed:14742258, PubMed:10491410). Plays a major role in the formation of EETs and hydroxy-EETs (HEETs) in kidney (PubMed:10491410, PubMed:14742258). Via EETs may inhibit the epithelial sodium channels (ENaCs) in nephron segments, preventing excessive sodium absorption during high dietary salt intake (By similarity). Participates in the formation of anti-inflammatory hydroxyepoxyeicosatrienoic acids (HEETs) by converting 20-hydroxyeicosatetraenoic acid (20-HETE) to 20,8,9-HEET, an activator of PPARA (PubMed:14742258). Metabolizes eicosapentaenoic acid (EPA, C20:5(n-3)) to epoxyeicosatetraenoic acid (EETeTr) regioisomers, 8,9-, 11,12-, 14,15-, and 17,18-EETeTr, preferentially producing 17R,18S enantiomer (PubMed:15766564). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8246128). Indicus|evm.model.CM009516.1.169 O75477 ERLN1_HUMAN 95.677 0.991404 1.00287 ERLIN1 - Erlin-1 - Homo sapiens (Human) - ERLIN1 gene Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618). Indicus|evm.model.CM009516.1.170 Q95KV1 IKKA_BOVIN 100.000 0.953548 1.0473 CHUK - Inhibitor of nuclear factor kappa-B kinase subunit alpha - Bos taurus (Bovine) - CHUK gene Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor. Interacts with SASH1 (By similarity). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Indicus|evm.model.CM009516.1.171 Q5R8R4 C19L1_PONAB 94.757 0.396873 2.49628 CWF19L1 - CWF19-like protein 1 - Pongo abelii (Sumatran orangutan) - CWF19L1 gene Indicus|evm.model.CM009516.1.172 Q9P0L9 PK2L1_HUMAN 83.621 0.966387 0.147826 PKD2L1 - Polycystic kidney disease 2-like 1 protein - Homo sapiens (Human) - PKD2L1 gene Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:23212381, PubMed:30004384). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336289). The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:19812697). The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:23212381). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity). Indicus|evm.model.CM009516.1.173 Q9TT94 SCD_BOVIN 84.483 0.217557 0.729805 SCD - Stearoyl-CoA desaturase - Bos taurus (Bovine) - SCD gene Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). Indicus|evm.model.CM009516.1.174 Q9TT94 SCD_BOVIN 99.609 0.913978 0.777159 SCD - Stearoyl-CoA desaturase - Bos taurus (Bovine) - SCD gene Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). Indicus|evm.model.CM009516.1.175 P31291 WNT8B_XENLA 94.737 0.151351 0.864486 wnt8b - Protein Wnt-8b precursor - Xenopus laevis (African clawed frog) - wnt8b gene Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in the initiation of dorsal axis development. May activate a Nieuwkoop center-like signaling pathway. Indicus|evm.model.CM009516.1.176 Q9NQW1 SC31B_HUMAN 83.206 0.998279 0.985581 SEC31B - Protein transport protein Sec31B - Homo sapiens (Human) - SEC31B gene As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum. Indicus|evm.model.CM009516.1.178 Q02372 NDUB8_BOVIN 100.000 0.989305 1.00538 NDUFB8 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor - Bos taurus (Bovine) - NDUFB8 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009516.1.179 Q9NWT6 HIF1N_HUMAN 97.135 0.994286 1.00287 HIF1AN - Hypoxia-inducible factor 1-alpha inhibitor - Homo sapiens (Human) - HIF1AN gene Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. Indicus|evm.model.CM009516.1.180 Q02962 PAX2_HUMAN 93.671 0.76971 1.15588 PAX2 - Paired box protein Pax-2 - Homo sapiens (Human) - PAX2 gene Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS. Indicus|evm.model.CM009516.1.181 Q8IX21 SLF2_HUMAN 88.085 0.998288 0.995737 SLF2 - SMC5-SMC6 complex localization factor protein 2 - Homo sapiens (Human) - SLF2 gene Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Indicus|evm.model.CM009516.1.182 Q9NTN9 SEM4G_HUMAN 91.943 0.997633 1.00835 SEMA4G - Semaphorin-4G precursor - Homo sapiens (Human) - SEMA4G gene Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity). Indicus|evm.model.CM009516.1.183 Q95KE5 RM43_BOVIN 100.000 0.9875 1.00629 MRPL43 - 39S ribosomal protein L43, mitochondrial precursor - Bos taurus (Bovine) - MRPL43 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009516.1.184 Q96RR1 PEO1_HUMAN 88.889 0.997076 1 TWNK - Twinkle protein, mitochondrial precursor - Homo sapiens (Human) - TWNK gene Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals. Indicus|evm.model.CM009516.1.185 A5PKL7 LZTS2_BOVIN 99.700 0.997006 1.0015 LZTS2 - Leucine zipper putative tumor suppressor 2 - Bos taurus (Bovine) - LZTS2 gene Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Indicus|evm.model.CM009516.1.186 Q9H5P4 PDZD7_HUMAN 88.163 0.997934 0.937076 PDZD7 - PDZ domain-containing protein 7 - Homo sapiens (Human) - PDZD7 gene In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. Indicus|evm.model.CM009516.1.187 A6QP55 SFXN3_BOVIN 99.682 0.899425 1.08411 SFXN3 - Sideroflexin-3 - Bos taurus (Bovine) - SFXN3 gene Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Indicus|evm.model.CM009516.1.188 Q96I82 KAZD1_HUMAN 93.478 0.901639 1.00329 KAZALD1 - Kazal-type serine protease inhibitor domain-containing protein 1 precursor - Homo sapiens (Human) - KAZALD1 gene Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly (By similarity). Indicus|evm.model.CM009516.1.189 P31314 TLX1_HUMAN 99.000 0.592262 1.01818 TLX1 - T-cell leukemia homeobox protein 1 - Homo sapiens (Human) - TLX1 gene Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. Indicus|evm.model.CM009516.1.191 P52955 LBX1_MOUSE 97.872 0.992933 1.00355 Lbx1 - Transcription factor LBX1 - Mus musculus (Mouse) - Lbx1 gene Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. Indicus|evm.model.CM009516.1.192 Q9Y297 FBW1A_HUMAN 99.669 0.9967 1.00165 BTRC - F-box/WD repeat-containing protein 1A - Homo sapiens (Human) - BTRC gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:25503564, PubMed:25704143, PubMed:9859996, PubMed:22087322). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14681206, PubMed:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:21258371, PubMed:18354482). Indicus|evm.model.CM009516.1.193 Q9UGP5 DPOLL_HUMAN 85.043 0.996528 1.00174 POLL - DNA polymerase lambda - Homo sapiens (Human) - POLL gene DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). Indicus|evm.model.CM009516.1.194 Q24K21 DPCD_BOVIN 99.015 0.990196 1.00493 DPCD - Protein DPCD - Bos taurus (Bovine) - DPCD gene May play a role in the formation or function of ciliated cells. Indicus|evm.model.CM009516.1.195 P57775 FBXW4_HUMAN 96.429 0.661591 1.43447 FBXW4 - F-box/WD repeat-containing protein 4 - Homo sapiens (Human) - FBXW4 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling. Indicus|evm.model.CM009516.1.196 P55075 FGF8_HUMAN 100.000 0.537092 1.44635 FGF8 - Fibroblast growth factor 8 precursor - Homo sapiens (Human) - FGF8 gene Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111). Indicus|evm.model.CM009516.1.197 O60502 OGA_HUMAN 99.017 0.997819 1.00109 OGA - Protein O-GlcNAcase - Homo sapiens (Human) - OGA gene Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). Indicus|evm.model.CM009516.1.198 Q9NS61 KCIP2_HUMAN 98.889 0.99262 1.0037 KCNIP2 - Kv channel-interacting protein 2 - Homo sapiens (Human) - KCNIP2 gene Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity). Indicus|evm.model.CM009516.1.199 Q5T2E6 ARMD3_HUMAN 99.637 0.996377 0.801161 ARMH3 - Armadillo-like helical domain-containing protein 3 - Homo sapiens (Human) - ARMH3 gene Involved in GBF1 recruitment, Golgi maintenance and protein secretion. Indicus|evm.model.CM009516.1.200 Q86YV9 HPS6_HUMAN 86.370 0.950125 1.03484 HPS6 - Hermansky-Pudlak syndrome 6 protein - Homo sapiens (Human) - HPS6 gene May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (PubMed:17041891). Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning (PubMed:25189619). Indicus|evm.model.CM009516.1.201 P70662 LDB1_MOUSE 100.000 0.994536 0.890511 Ldb1 - LIM domain-binding protein 1 - Mus musculus (Mouse) - Ldb1 gene Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. Indicus|evm.model.CM009516.1.202 Q5VV67 PPRC1_HUMAN 81.581 0.998797 0.999399 PPRC1 - Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 - Homo sapiens (Human) - PPRC1 gene Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. Indicus|evm.model.CM009516.1.203 Q14978 NOLC1_HUMAN 77.856 0.997143 1.00143 NOLC1 - Nucleolar and coiled-body phosphoprotein 1 - Homo sapiens (Human) - NOLC1 gene Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). Indicus|evm.model.CM009516.1.204 Q9HB03 ELOV3_HUMAN 75.556 0.99262 1.0037 ELOVL3 - Elongation of very long chain fatty acids protein 3 - Homo sapiens (Human) - ELOVL3 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Indicus|evm.model.CM009516.1.205 O35160 PITX3_MOUSE 97.020 0.993399 1.00331 Pitx3 - Pituitary homeobox 3 - Mus musculus (Mouse) - Pitx3 gene Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle. Indicus|evm.model.CM009516.1.206 Q92538 GBF1_HUMAN 95.271 0.998924 0.999462 GBF1 - Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 - Homo sapiens (Human) - GBF1 gene Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:12047556, PubMed:12808027, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adapter protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516). Indicus|evm.model.CM009516.1.207 Q00653 NFKB2_HUMAN 88.235 0.997719 0.974444 NFKB2 - Nuclear factor NF-kappa-B p100 subunit - Homo sapiens (Human) - NFKB2 gene NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Indicus|evm.model.CM009516.1.208 F1MUS9 PSD1_BOVIN 98.830 0.998053 1.00097 PSD - PH and SEC7 domain-containing protein 1 - Bos taurus (Bovine) - PSD gene Guanine nucleotide exchange factor for ARF6 (By similarity). Induces cytoskeletal remodeling (By similarity). Indicus|evm.model.CM009516.1.209 E1BNS0 FXL15_BOVIN 100.000 0.993355 1.00333 FBXL15 - F-box/LRR-repeat protein 15 - Bos taurus (Bovine) - FBXL15 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Indicus|evm.model.CM009516.1.210 Q3ZBN4 CUED2_BOVIN 82.686 0.991525 0.833922 CUEDC2 - CUE domain-containing protein 2 - Bos taurus (Bovine) - CUEDC2 gene Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Indicus|evm.model.CM009516.1.212 Q58CT4 MF13A_BOVIN 100.000 0.996139 1.00193 MFSD13A - Transmembrane protein 180 - Bos taurus (Bovine) - MFSD13A gene Indicus|evm.model.CM009516.1.213 P85515 ACTZ_RAT 100.000 0.994695 1.00266 Actr1a - Alpha-centractin - Rattus norvegicus (Rat) - Actr1a gene Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity). Indicus|evm.model.CM009516.1.215 Q9BZR9 TRIM8_HUMAN 99.274 0.996377 1.00181 TRIM8 - E3 ubiquitin-protein ligase TRIM8 - Homo sapiens (Human) - TRIM8 gene E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:27981609, PubMed:28747347). Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791, PubMed:27981609). Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148). Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347). Indicus|evm.model.CM009516.1.216 Q2TBW6 ARL3_BOVIN 100.000 0.989071 1.00549 ARL3 - ADP-ribosylation factor-like protein 3 - Bos taurus (Bovine) - ARL3 gene Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity). Indicus|evm.model.CM009516.1.217 Q5EA43 SFXN2_BOVIN 100.000 0.993808 1.00311 SFXN2 - Sideroflexin-2 - Bos taurus (Bovine) - SFXN2 gene Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. Indicus|evm.model.CM009516.1.218 Q9NX94 WBP1L_HUMAN 86.765 0.918699 1.07895 WBP1L - WW domain binding protein 1-like - Homo sapiens (Human) - WBP1L gene Indicus|evm.model.CM009516.1.219 P05185 CP17A_BOVIN 100.000 0.994118 1.00196 CYP17A1 - Steroid 17-alpha-hydroxylase/17,20 lyase - Bos taurus (Bovine) - CYP17A1 gene A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.CM009516.1.220 Q2KIB7 BORC7_BOVIN 100.000 0.195506 4.2381 BORCS7 - BLOC-1-related complex subunit 7 - Bos taurus (Bovine) - BORCS7 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Indicus|evm.model.CM009516.1.221 Q9H8M5 CNNM2_HUMAN 96.229 0.997658 0.976 CNNM2 - Metal transporter CNNM2 - Homo sapiens (Human) - CNNM2 gene Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). Indicus|evm.model.CM009516.1.222 O46411 5NTC_BOVIN 100.000 0.996435 1.00179 NT5C2 - Cytosolic purine 5'-nucleotidase - Bos taurus (Bovine) - NT5C2 gene May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. Indicus|evm.model.CM009516.1.223 Q08DH7 AINX_BOVIN 100.000 0.996 1.002 INA - Alpha-internexin - Bos taurus (Bovine) - INA gene Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges (By similarity). May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity). Indicus|evm.model.CM009516.1.224 Q9BYE7 PCGF6_HUMAN 94.017 0.994318 1.00571 PCGF6 - Polycomb group RING finger protein 6 - Homo sapiens (Human) - PCGF6 gene Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Indicus|evm.model.CM009516.1.225 Q15542 TAF5_HUMAN 96.114 0.961151 0.86875 TAF5 - Transcription initiation factor TFIID subunit 5 - Homo sapiens (Human) - TAF5 gene TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed. Indicus|evm.model.CM009516.1.226 A7MB10 RRP5_BOVIN 99.680 0.998933 1.00053 PDCD11 - Protein RRP5 homolog - Bos taurus (Bovine) - PDCD11 gene Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (By similarity). Indicus|evm.model.CM009516.1.227 Q2HJ63 CAHM2_BOVIN 99.690 0.993827 1.0031 CALHM2 - Calcium homeostasis modulator protein 2 - Bos taurus (Bovine) - CALHM2 gene Pore-forming subunit of a voltage-gated ion channel. Indicus|evm.model.CM009516.1.228 Q8IU99 CAHM1_HUMAN 93.043 0.994203 0.99711 CALHM1 - Calcium homeostasis modulator protein 1 - Homo sapiens (Human) - CALHM1 gene Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes (By similarity). Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (By similarity). Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (By similarity). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration (PubMed:22711817, PubMed:23300080). Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions (PubMed:22711817). Acts as an activator of the ERK1 and ERK2 cascade (PubMed:23345406). Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (PubMed:21574960). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner (PubMed:18585350). Indicus|evm.model.CM009516.1.229 Q86XJ0 CAHM3_HUMAN 88.372 0.994203 1.00291 CALHM3 - Calcium homeostasis modulator protein 3 - Homo sapiens (Human) - CALHM3 gene Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances. Indicus|evm.model.CM009516.1.230 Q2YGT9 RL6_PIG 66.460 0.589286 0.788732 RPL6 - 60S ribosomal protein L6 - Sus scrofa (Pig) - RPL6 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009516.1.231 O76050 NEUL1_HUMAN 89.253 0.982079 0.972125 NEURL1 - E3 ubiquitin-protein ligase NEURL1 - Homo sapiens (Human) - NEURL1 gene Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. Indicus|evm.model.CM009516.1.232 Q5TCZ1 SPD2A_HUMAN 92.111 0.983855 0.874669 SH3PXD2A - SH3 and PX domain-containing protein 2A - Homo sapiens (Human) - SH3PXD2A gene Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. Indicus|evm.model.CM009516.1.233 Q5TCZ1 SPD2A_HUMAN 100.000 0.985075 0.11827 SH3PXD2A - SH3 and PX domain-containing protein 2A - Homo sapiens (Human) - SH3PXD2A gene Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. Indicus|evm.model.CM009516.1.234 O95671 ASML_HUMAN 58.242 0.987109 0.874396 ASMTL - Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein - Homo sapiens (Human) - ASMTL gene Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). Indicus|evm.model.CM009516.1.235 Q08DB2 STN1_BOVIN 100.000 0.882775 1.12973 STN1 - CST complex subunit STN1 - Bos taurus (Bovine) - STN1 gene Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity). Indicus|evm.model.CM009516.1.236 Q9H2G2 SLK_HUMAN 88.003 0.998388 1.00486 SLK - STE20-like serine/threonine-protein kinase - Homo sapiens (Human) - SLK gene Mediates apoptosis and actin stress fiber dissolution. Indicus|evm.model.CM009516.1.237 A6QPB3 COHA1_BOVIN 98.788 0.980185 1.02783 COL17A1 - Collagen alpha-1(XVII) chain - Bos taurus (Bovine) - COL17A1 gene May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. Indicus|evm.model.CM009516.1.238 Q86XK3 SFR1_HUMAN 82.041 0.991803 0.995918 SFR1 - Swi5-dependent recombination DNA repair protein 1 homolog - Homo sapiens (Human) - SFR1 gene Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). Indicus|evm.model.CM009516.1.239 Q8NDM7 CFA43_HUMAN 79.868 0.998802 1.0024 CFAP43 - Cilia- and flagella-associated protein 43 - Homo sapiens (Human) - CFAP43 gene Flagellar protein involved in sperm flagellum axoneme organization and function (By similarity). Involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Indicus|evm.model.CM009516.1.240 P78417 GSTO1_HUMAN 82.573 0.991736 1.00415 GSTO1 - Glutathione S-transferase omega-1 - Homo sapiens (Human) - GSTO1 gene Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Indicus|evm.model.CM009516.1.241 P78417 GSTO1_HUMAN 82.988 0.991736 1.00415 GSTO1 - Glutathione S-transferase omega-1 - Homo sapiens (Human) - GSTO1 gene Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Indicus|evm.model.CM009516.1.242 Q9H4Y5 GSTO2_HUMAN 85.124 0.983673 1.00823 GSTO2 - Glutathione S-transferase omega-2 - Homo sapiens (Human) - GSTO2 gene Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). Indicus|evm.model.CM009516.1.243 A7MB64 IPRI_BOVIN 100.000 0.996409 1.0018 ITPRIP - Inositol 1,4,5-trisphosphate receptor-interacting protein precursor - Bos taurus (Bovine) - ITPRIP gene Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release. Indicus|evm.model.CM009516.1.244 Q5T655 CFA58_HUMAN 91.101 0.975973 1.00229 CFAP58 - Cilia- and flagella-associated protein 58 - Homo sapiens (Human) - CFAP58 gene cytoskeleton, extracellular space Indicus|evm.model.CM009516.1.246 Q8WY21 SORC1_HUMAN 93.548 0.11583 0.221747 SORCS1 - VPS10 domain-containing receptor SorCS1 precursor - Homo sapiens (Human) - SORCS1 gene Golgi apparatus, integral component of membrane, membrane, neuropeptide receptor activity, neuropeptide signaling pathway, post-Golgi vesicle-mediated transport Indicus|evm.model.CM009516.1.247 Q9UGM3 DMBT1_HUMAN 67.797 0.0585859 0.410278 DMBT1 - Deleted in malignant brain tumors 1 protein precursor - Homo sapiens (Human) - DMBT1 gene May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. Indicus|evm.model.CM009516.1.249 O95222 OR6A2_HUMAN 63.366 0.92236 0.984709 OR6A2 - Olfactory receptor 6A2 - Homo sapiens (Human) - OR6A2 gene Odorant receptor. Indicus|evm.model.CM009516.1.251 Q4PS77 MTG1_BOVIN 96.988 0.993921 0.990964 MTG1 - Mitochondrial ribosome-associated GTPase 1 precursor - Bos taurus (Bovine) - MTG1 gene Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity). Indicus|evm.model.CM009516.1.252 Q865R1 PAOX_BOVIN 99.609 0.781346 1.27734 PAOX - Peroxisomal N(1)-acetyl-spermine/spermidine oxidase precursor - Bos taurus (Bovine) - PAOX gene Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration. Indicus|evm.model.CM009516.1.253 Q58DM8 ECHM_BOVIN 99.310 0.993127 1.00345 ECHS1 - Enoyl-CoA hydratase, mitochondrial precursor - Bos taurus (Bovine) - ECHS1 gene Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity). Indicus|evm.model.CM009516.1.254 Q0P563 FUCM_BOVIN 98.701 0.987097 1.01307 FUOM - Fucose mutarotase - Bos taurus (Bovine) - FUOM gene Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. Indicus|evm.model.CM009516.1.255 Q80XD8 PRAP1_MOUSE 50.000 0.634703 1.4698 Prap1 - Proline-rich acidic protein 1 precursor - Mus musculus (Mouse) - Prap1 gene Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (PubMed:33168624). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (PubMed:32629119). May play an important role in maintaining normal growth homeostasis in epithelial cells (By similarity). Involved in p53/TP53-dependent cell survival after DNA damage (By similarity). Indicus|evm.model.CM009516.1.257 Q9DCA7 CALY_MOUSE 72.159 0.734783 1.0177 Caly - Neuron-specific vesicular protein calcyon - Mus musculus (Mouse) - Caly gene Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. Indicus|evm.model.CM009516.1.259 Q2VL84 MSX1_CALJA 70.192 0.559783 0.607261 MSX1 - Homeobox protein MSX-1 - Callithrix jacchus (White-tufted-ear marmoset) - MSX1 gene Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). Indicus|evm.model.CM009516.1.260 Q8NB15 ZN511_HUMAN 72.043 0.953608 0.769841 ZNF511 - Zinc finger protein 511 - Homo sapiens (Human) - ZNF511 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009516.1.261 Q921G8 GCP2_MOUSE 89.282 0.997783 0.996685 Tubgcp2 - Gamma-tubulin complex component 2 - Mus musculus (Mouse) - Tubgcp2 gene Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Plays a role in neuronal migration. Indicus|evm.model.CM009516.1.262 P78325 ADAM8_HUMAN 64.066 0.997619 1.01942 ADAM8 - Disintegrin and metalloproteinase domain-containing protein 8 precursor - Homo sapiens (Human) - ADAM8 gene Possible involvement in extravasation of leukocytes. Indicus|evm.model.CM009516.1.263 Q0IH24 SPEF1_XENLA 55.319 0.187755 1.06987 spef1 - Sperm flagellar protein 1 - Xenopus laevis (African clawed frog) - spef1 gene Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (PubMed:25070955). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities (By similarity). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (PubMed:29514918). Indicus|evm.model.CM009516.1.264 Q5T230 UTF1_HUMAN 74.375 0.709821 0.656891 UTF1 - Undifferentiated embryonic cell transcription factor 1 - Homo sapiens (Human) - UTF1 gene Acts as a transcriptional coactivator of ATF2. Indicus|evm.model.CM009516.1.265 Q76NI1 KNDC1_HUMAN 88.265 0.960591 0.116066 KNDC1 - Kinase non-catalytic C-lobe domain-containing protein 1 - Homo sapiens (Human) - KNDC1 gene RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). Indicus|evm.model.CM009516.1.266 Q9UPU3 SORC3_HUMAN 92.588 0.997672 0.702946 SORCS3 - VPS10 domain-containing receptor SorCS3 precursor - Homo sapiens (Human) - SORCS3 gene integral component of membrane, integral component of postsynaptic density membrane, membrane, neuropeptide receptor activity, neuropeptide signaling pathway Indicus|evm.model.CM009516.1.268 Q8WY21 SORC1_HUMAN 76.190 0.639566 0.631849 SORCS1 - VPS10 domain-containing receptor SorCS1 precursor - Homo sapiens (Human) - SORCS1 gene Golgi apparatus, integral component of membrane, membrane, neuropeptide receptor activity, neuropeptide signaling pathway, post-Golgi vesicle-mediated transport Indicus|evm.model.CM009516.1.269 Q8WY21 SORC1_HUMAN 100.000 0.981132 0.0453767 SORCS1 - VPS10 domain-containing receptor SorCS1 precursor - Homo sapiens (Human) - SORCS1 gene Golgi apparatus, integral component of membrane, membrane, neuropeptide receptor activity, neuropeptide signaling pathway, post-Golgi vesicle-mediated transport Indicus|evm.model.CM009516.1.270 Q8VI51 SORC3_MOUSE 90.625 0.15736 0.161608 Sorcs3 - VPS10 domain-containing receptor SorCS3 precursor - Mus musculus (Mouse) - Sorcs3 gene glutamatergic synapse, integral component of membrane, integral component of postsynaptic density membrane, postsynaptic density, learning, memory, regulation of long-term synaptic depression Indicus|evm.model.CM009516.1.274 Q9D6Z1 NOP56_MOUSE 52.439 0.148148 0.558621 Nop56 - Nucleolar protein 56 - Mus musculus (Mouse) - Nop56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Indicus|evm.model.CM009516.1.275 Q3SZ63 NOP56_BOVIN 97.619 0.984252 0.213087 NOP56 - Nucleolar protein 56 - Bos taurus (Bovine) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Indicus|evm.model.CM009516.1.277 Q1JPJ2 XPP1_BOVIN 100.000 0.932534 1.07063 XPNPEP1 - Xaa-Pro aminopeptidase 1 - Bos taurus (Bovine) - XPNPEP1 gene Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity). Indicus|evm.model.CM009516.1.278 Q9HBH7 BEX1_HUMAN 91.667 0.435185 0.864 BEX1 - Protein BEX1 - Homo sapiens (Human) - BEX1 gene Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). Indicus|evm.model.CM009516.1.280 Q9UEY8 ADDG_HUMAN 96.081 0.997101 0.977337 ADD3 - Gamma-adducin - Homo sapiens (Human) - ADD3 gene Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin. Indicus|evm.model.CM009516.1.281 O09015 MXI1_RAT 95.089 0.763699 1.2807 Mxi1 - Max-interacting protein 1 - Rattus norvegicus (Rat) - Mxi1 gene Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. Indicus|evm.model.CM009516.1.282 Q5R591 SPF30_PONAB 99.580 0.940476 1.05882 SMNDC1 - Survival of motor neuron-related-splicing factor 30 - Pongo abelii (Sumatran orangutan) - SMNDC1 gene Necessary for spliceosome assembly. Overexpression causes apoptosis (By similarity). Indicus|evm.model.CM009516.1.283 Q16690 DUS5_HUMAN 93.490 0.836245 1.19271 DUSP5 - Dual specificity protein phosphatase 5 - Homo sapiens (Human) - DUSP5 gene Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. Indicus|evm.model.CM009516.1.284 O95196 CSPG5_HUMAN 81.351 0.87619 0.742049 CSPG5 - Chondroitin sulfate proteoglycan 5 precursor - Homo sapiens (Human) - CSPG5 gene May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. Indicus|evm.model.CM009516.1.285 Q5R4K5 SMC3_PONAB 98.862 0.998375 1.0115 SMC3 - Structural maintenance of chromosomes protein 3 - Pongo abelii (Sumatran orangutan) - SMC3 gene Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity). Indicus|evm.model.CM009516.1.290 Q5T481 RBM20_HUMAN 84.642 0.984602 0.95273 RBM20 - RNA-binding protein 20 - Homo sapiens (Human) - RBM20 gene RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin). Indicus|evm.model.CM009516.1.292 Q9JID1 PDCD4_RAT 97.015 0.995745 1.00213 Pdcd4 - Programmed cell death protein 4 - Rattus norvegicus (Rat) - Pdcd4 gene Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). Indicus|evm.model.CM009516.1.293 A8MTZ0 BBIP1_HUMAN 83.117 0.174825 4.66304 BBIP1 - BBSome-interacting protein 1 - Homo sapiens (Human) - BBIP1 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for primary cilia assembly and BBSome stability. Regulates cytoplasmic microtubule stability and acetylation. Indicus|evm.model.CM009516.1.294 A6QLV3 SHOC2_BOVIN 100.000 0.996569 1.00172 SHOC2 - Leucine-rich repeat protein SHOC-2 - Bos taurus (Bovine) - SHOC2 gene Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. Indicus|evm.model.CM009516.1.295 Q28838 ADA2A_BOVIN 100.000 0.262658 0.675214 ADRA2A - Alpha-2A adrenergic receptor - Bos taurus (Bovine) - ADRA2A gene Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). Indicus|evm.model.CM009516.1.297 Q5GJ77 GPAT1_BOVIN 98.788 0.997579 1.00121 GPAM - Glycerol-3-phosphate acyltransferase 1, mitochondrial precursor - Bos taurus (Bovine) - GPAM gene Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids. Indicus|evm.model.CM009516.1.298 Q96PL2 TECTB_HUMAN 95.137 0.993939 1.00304 TECTB - Beta-tectorin precursor - Homo sapiens (Human) - TECTB gene One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Indicus|evm.model.CM009516.1.299 P55205 GUC2G_RAT 71.053 0.308424 0.669091 Gucy2g - Guanylate cyclase 2G precursor - Rattus norvegicus (Rat) - Gucy2g gene Binds to a yet not identified ligand. Indicus|evm.model.CM009516.1.300 O88813 ACSL5_RAT 81.991 0.92663 1.0776 Acsl5 - Long-chain-fatty-acid--CoA ligase 5 - Rattus norvegicus (Rat) - Acsl5 gene Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804). ACSL5 may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL at the villus tip of the crypt-villus axis of the small intestine (By similarity). May have a role in the survival of glioma cells (By similarity). May activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. It was suggested that it may also stimulate fatty acid oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. Indicus|evm.model.CM009516.1.301 Q2HJ95 ZDHC6_BOVIN 100.000 0.995169 1.00242 ZDHHC6 - Palmitoyltransferase ZDHHC6 - Bos taurus (Bovine) - ZDHHC6 gene Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (By similarity). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (By similarity). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (By similarity). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (By similarity). Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation (By similarity). Indicus|evm.model.CM009516.1.302 Q96AJ9 VTI1A_HUMAN 95.349 0.984615 0.599078 VTI1A - Vesicle transport through interaction with t-SNAREs homolog 1A - Homo sapiens (Human) - VTI1A gene V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. Indicus|evm.model.CM009516.1.303 Q924A0 TF7L2_MOUSE 98.777 0.695096 1.02179 Tcf7l2 - Transcription factor 7-like 2 - Mus musculus (Mouse) - Tcf7l2 gene Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. Indicus|evm.model.CM009516.1.305 Q5E9Z2 HABP2_BOVIN 99.642 0.996422 1.00179 HABP2 - Hyaluronan-binding protein 2 precursor - Bos taurus (Bovine) - HABP2 gene Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity). Indicus|evm.model.CM009516.1.306 Q86VF7 NRAP_HUMAN 90.809 0.998845 1.00058 NRAP - Nebulin-related-anchoring protein - Homo sapiens (Human) - NRAP gene May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. Indicus|evm.model.CM009516.1.307 P55210 CASP7_HUMAN 81.763 0.728889 1.48515 CASP7 - Caspase-7 precursor - Homo sapiens (Human) - CASP7 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. Indicus|evm.model.CM009516.1.308 Q5SXH7 PKHS1_HUMAN 56.735 0.793443 0.655914 PLEKHS1 - Pleckstrin homology domain-containing family S member 1 - Homo sapiens (Human) - PLEKHS1 gene Indicus|evm.model.CM009516.1.309 Q6PJP8 DCR1A_HUMAN 73.314 0.998099 1.01154 DCLRE1A - DNA cross-link repair 1A protein - Homo sapiens (Human) - DCLRE1A gene May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Indicus|evm.model.CM009516.1.310 A4IF69 NHLC2_BOVIN 100.000 0.997249 1.00138 NHLRC2 - NHL repeat-containing protein 2 - Bos taurus (Bovine) - NHLRC2 gene Required for normal embryonic development. Indicus|evm.model.CM009516.1.311 Q9TT96 ADRB1_BOVIN 98.715 0.995726 1.00214 ADRB1 - Beta-1 adrenergic receptor - Bos taurus (Bovine) - ADRB1 gene Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). Indicus|evm.model.CM009516.1.312 Q5R9B3 CC186_PONAB 95.100 0.69288 1.36575 CCDC186 - Coiled-coil domain-containing protein 186 - Pongo abelii (Sumatran orangutan) - CCDC186 gene Indicus|evm.model.CM009516.1.313 Q9BXT4 TDRD1_HUMAN 79.223 0.961789 1.04237 TDRD1 - Tudor domain-containing protein 1 - Homo sapiens (Human) - TDRD1 gene Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity). Indicus|evm.model.CM009516.1.314 Q5GFL6 VWA2_HUMAN 80.212 0.75502 1.31921 VWA2 - von Willebrand factor A domain-containing protein 2 precursor - Homo sapiens (Human) - VWA2 gene basement membrane, collagen-containing extracellular matrix, extracellular exosome, extracellular space, identical protein binding, calcium-independent cell-matrix adhesion, regulation of insulin receptor signaling pathway Indicus|evm.model.CM009516.1.315 Q17R10 AF1L2_BOVIN 99.753 0.964286 1.02815 AFAP1L2 - Actin filament-associated protein 1-like 2 - Bos taurus (Bovine) - AFAP1L2 gene May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation (By similarity). Indicus|evm.model.CM009516.1.316 O14639 ABLM1_HUMAN 88.136 0.989691 0.872751 ABLIM1 - Actin-binding LIM protein 1 - Homo sapiens (Human) - ABLIM1 gene May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. Indicus|evm.model.CM009516.1.317 Q68FI1 L14BA_XENLA 66.346 0.309524 0.696682 lsm14b-a - Protein LSM14 homolog B-A - Xenopus laevis (African clawed frog) - lsm14b-a gene May be involved in the storage of translationally inactive mRNAs and protect them from degradation (By similarity). Plays a role in control of mRNA translation (PubMed:18631138). Indicus|evm.model.CM009516.1.319 A0JNG7 F16B1_BOVIN 100.000 0.997389 1.00131 FHIP2A - FHF complex subunit HOOK interacting protein 2A - Bos taurus (Bovine) - FHIP2A gene May be required for proper functioning of the nervous system. Indicus|evm.model.CM009516.1.321 Q8WWH5 TRUB1_HUMAN 91.738 0.991501 1.01146 TRUB1 - Probable tRNA pseudouridine synthase 1 - Homo sapiens (Human) - TRUB1 gene Pseudouridine synthase that catalyzes pseudouridylation of mRNAs (PubMed:28073919). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Indicus|evm.model.CM009516.1.323 P56159 GFRA1_HUMAN 96.512 0.760355 0.726882 GFRA1 - GDNF family receptor alpha-1 precursor - Homo sapiens (Human) - GFRA1 gene Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity). Indicus|evm.model.CM009516.1.325 Q2YDH9 CC172_BOVIN 99.231 0.992337 1.00385 CCDC172 - Coiled-coil domain-containing protein 172 - Bos taurus (Bovine) - CCDC172 gene cytoplasm, sperm midpiece Indicus|evm.model.CM009516.1.326 Q17RR3 LIPR3_HUMAN 79.957 0.995745 1.00642 PNLIPRP3 - Pancreatic lipase-related protein 3 precursor - Homo sapiens (Human) - PNLIPRP3 gene extracellular space, lipase activity, triglyceride lipase activity, lipid catabolic process Indicus|evm.model.CM009516.1.327 Q8IXB1 DJC10_HUMAN 90.943 0.997487 1.00378 DNAJC10 - DnaJ homolog subfamily C member 10 precursor - Homo sapiens (Human) - DNAJC10 gene Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. Indicus|evm.model.CM009516.1.328 P16233 LIPP_HUMAN 84.222 0.984649 0.980645 PNLIP - Pancreatic triacylglycerol lipase precursor - Homo sapiens (Human) - PNLIP gene Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones. Indicus|evm.model.CM009516.1.329 P54315 LIPR1_HUMAN 81.884 0.568465 0.51606 PNLIPRP1 - Inactive pancreatic lipase-related protein 1 precursor - Homo sapiens (Human) - PNLIPRP1 gene May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity). Indicus|evm.model.CM009516.1.330 A5PK46 LIPR2_BOVIN 97.000 0.74812 0.567164 PNLIPRP2 - Pancreatic lipase-related protein 2 precursor - Bos taurus (Bovine) - PNLIPRP2 gene Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short- medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylates triacylglycerols. When liver matures and bile salt synthesis increases, it likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in plant-based diet releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency (By similarity). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Has also low phospholipase activity, but its physiological relevance is not clear (By similarity). Indicus|evm.model.CM009516.1.331 A6QPC0 CJ082_BOVIN 98.723 0.257993 3.85957 Uncharacterized protein C10orf82 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009516.1.333 A6NNW6 ENO4_HUMAN 82.876 0.995114 0.9824 ENO4 - Enolase 4 - Homo sapiens (Human) - ENO4 gene May be required for sperm motility and function. Indicus|evm.model.CM009516.1.334 Q5RA03 SHOT1_PONAB 91.009 0.72337 1.37939 SHTN1 - Shootin-1 - Pongo abelii (Sumatran orangutan) - SHTN1 gene Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. Indicus|evm.model.CM009516.1.335 Q2NKI2 VAX1_MOUSE 98.571 0.207207 0.985207 Vax1 - Ventral anterior homeobox 1 - Mus musculus (Mouse) - Vax1 gene Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk. Indicus|evm.model.CM009516.1.337 Q7Z418 KCNKI_HUMAN 73.177 0.994751 0.992188 KCNK18 - Potassium channel subfamily K member 18 - Homo sapiens (Human) - KCNK18 gene Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). Indicus|evm.model.CM009516.1.338 Q27963 VMAT2_BOVIN 99.807 0.996139 1.00193 SLC18A2 - Synaptic vesicular amine transporter - Bos taurus (Bovine) - SLC18A2 gene Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Indicus|evm.model.CM009516.1.339 Q8NEN9 PDZD8_HUMAN 89.974 0.998268 1.00087 PDZD8 - PDZ domain-containing protein 8 - Homo sapiens (Human) - PDZD8 gene Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). Indicus|evm.model.CM009516.1.340 Q17R00 EMX2_BOVIN 98.814 0.601918 1.64822 EMX2 - Homeobox protein EMX2 - Bos taurus (Bovine) - EMX2 gene Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system (By similarity). Indicus|evm.model.CM009516.1.342 Q7L804 RFIP2_HUMAN 92.773 0.996094 1 RAB11FIP2 - Rab11 family-interacting protein 2 - Homo sapiens (Human) - RAB11FIP2 gene A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. Indicus|evm.model.CM009516.1.343 Q3ZCI6 F204A_BOVIN 100.000 0.991453 1.00429 FAM204A - Protein FAM204A - Bos taurus (Bovine) - FAM204A gene Indicus|evm.model.CM009516.1.344 Q4EW11 PRLHR_BOVIN 100.000 0.994609 1.0027 PRLHR - Prolactin-releasing peptide receptor - Bos taurus (Bovine) - PRLHR gene Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing (By similarity). Indicus|evm.model.CM009516.1.345 Q86Y37 CACL1_HUMAN 82.031 0.991111 0.609756 CACUL1 - CDK2-associated and cullin domain-containing protein 1 - Homo sapiens (Human) - CACUL1 gene Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. Indicus|evm.model.CM009516.1.346 Q5R9I1 MTUS1_PONAB 79.365 0.632653 0.0771654 MTUS1 - Microtubule-associated tumor suppressor 1 homolog - Pongo abelii (Sumatran orangutan) - MTUS1 gene Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity). Indicus|evm.model.CM009516.1.347 Q8WY41 NANO1_HUMAN 94.828 0.66474 0.592466 NANOS1 - Nanos homolog 1 - Homo sapiens (Human) - NANOS1 gene May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. Indicus|evm.model.CM009516.1.348 Q14152 EIF3A_HUMAN 93.669 0.998548 0.996382 EIF3A - Eukaryotic translation initiation factor 3 subunit A - Homo sapiens (Human) - EIF3A gene RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). Indicus|evm.model.CM009516.1.349 Q8TCE6 DEN10_HUMAN 94.678 0.994413 1.0028 DENND10 - DENN domain-containing protein 10 - Homo sapiens (Human) - DENND10 gene Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form. Indicus|evm.model.CM009516.1.350 Q3T0M2 SFXN4_BOVIN 100.000 0.993631 1.00319 SFXN4 - Sideroflexin-4 - Bos taurus (Bovine) - SFXN4 gene Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity). Indicus|evm.model.CM009516.1.351 P35705 PRDX3_BOVIN 100.000 0.992248 1.00389 PRDX3 - Thioredoxin-dependent peroxide reductase, mitochondrial precursor - Bos taurus (Bovine) - PRDX3 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Indicus|evm.model.CM009516.1.353 P43249 GRK5_BOVIN 97.400 0.961603 1.01525 GRK5 - G protein-coupled receptor kinase 5 - Bos taurus (Bovine) - GRK5 gene Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors (Beta-2 adrenergic receptor), muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro) (By similarity). Indicus|evm.model.CM009516.1.354 Q2KHW7 RGS10_BOVIN 100.000 0.989011 1.00552 RGS10 - Regulator of G-protein signaling 10 - Bos taurus (Bovine) - RGS10 gene Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein. Indicus|evm.model.CM009516.1.355 Q01085 TIAR_HUMAN 100.000 0.994681 1.00267 TIAL1 - Nucleolysin TIAR - Homo sapiens (Human) - TIAL1 gene RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. Indicus|evm.model.CM009516.1.356 O95817 BAG3_HUMAN 82.373 0.996587 1.01913 BAG3 - BAG family molecular chaperone regulator 3 - Homo sapiens (Human) - BAG3 gene Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). Indicus|evm.model.CM009516.1.357 Q9Y2H2 SAC2_HUMAN 83.349 0.983447 0.907244 INPP5F - Phosphatidylinositide phosphatase SAC2 - Homo sapiens (Human) - INPP5F gene Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). Indicus|evm.model.CM009516.1.358 A5PJM5 MCMBP_BOVIN 96.870 0.965204 1.0296 MCMBP - Mini-chromosome maintenance complex-binding protein - Bos taurus (Bovine) - MCMBP gene Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). Indicus|evm.model.CM009516.1.359 Q9Y6Y8 S23IP_HUMAN 90.060 0.998014 1.007 SEC23IP - SEC23-interacting protein - Homo sapiens (Human) - SEC23IP gene Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). Indicus|evm.model.CM009516.1.360 Q5VZY2 PLPP4_HUMAN 99.206 0.839465 1.10332 PLPP4 - Phospholipid phosphatase 4 - Homo sapiens (Human) - PLPP4 gene Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol (PubMed:28851360). Indicus|evm.model.CM009516.1.361 Q9BZH6 WDR11_HUMAN 96.108 0.937252 1.02859 WDR11 - WD repeat-containing protein 11 - Homo sapiens (Human) - WDR11 gene Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Indicus|evm.model.CM009516.1.362 P21802 FGFR2_HUMAN 92.597 0.975 1.02314 FGFR2 - Fibroblast growth factor receptor 2 precursor - Homo sapiens (Human) - FGFR2 gene Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Indicus|evm.model.CM009516.1.363 O95260 ATE1_HUMAN 87.091 0.996146 1.00193 ATE1 - Arginyl-tRNA--protein transferase 1 - Homo sapiens (Human) - ATE1 gene Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). Indicus|evm.model.CM009516.1.364 Q8R0E5 ZRAS1_MOUSE 40.217 0.491803 1.71831 Znrd1-as - Putative uncharacterized protein ZNRD1-AS1 - Mus musculus (Mouse) - Znrd1-as gene May be involved in male sterility. Indicus|evm.model.CM009516.1.365 Q2TBI1 NSE4A_BOVIN 100.000 0.994778 1.00262 NSMCE4A - Non-structural maintenance of chromosomes element 4 homolog A - Bos taurus (Bovine) - NSMCE4A gene Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). Indicus|evm.model.CM009516.1.366 Q6Y685 TACC1_MOUSE 72.381 0.0747764 3.61111 Tacc1 - Transforming acidic coiled-coil-containing protein 1 - Mus musculus (Mouse) - Tacc1 gene Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors (By similarity). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. Indicus|evm.model.CM009516.1.367 Q32L18 BTBDG_BOVIN 98.024 0.935185 1.08216 BTBD16 - BTB/POZ domain-containing protein 16 - Bos taurus (Bovine) - BTBD16 gene Indicus|evm.model.CM009516.1.368 Q8BUL6 PKHA1_MOUSE 96.000 0.738272 1.05744 Plekha1 - Pleckstrin homology domain-containing family A member 1 - Mus musculus (Mouse) - Plekha1 gene Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). Indicus|evm.model.CM009516.1.369 F1N152 HTRA1_BOVIN 100.000 0.157598 1.09446 HTRA1 - Serine protease HTRA1 precursor - Bos taurus (Bovine) - HTRA1 gene Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By similarity). Indicus|evm.model.CM009516.1.370 Q9UGM3 DMBT1_HUMAN 75.849 0.492782 0.430584 DMBT1 - Deleted in malignant brain tumors 1 protein precursor - Homo sapiens (Human) - DMBT1 gene May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. Indicus|evm.model.CM009516.1.371 P82292 Z13_BOVIN 95.690 0.454545 2.18103 Spermadhesin Z13 - Bos taurus (Bovine) Indicus|evm.model.CM009516.1.372 P29392 SPAD1_BOVIN 100.000 0.985185 1.00746 SPADH1 - Spermadhesin-1 precursor - Bos taurus (Bovine) - SPADH1 gene Stimulates cell division and progesterone secretion of bovine granulosa cells in vitro in a potent and dose dependent manner. This protein appears to be a potent growth factor with effects on ovarian granulosa cells. Indicus|evm.model.CM009516.1.373 Q32KT7 CJ120_BOVIN 99.417 0.994186 1.00292 Uncharacterized protein C10orf120 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009516.1.374 Q9UGM3 DMBT1_HUMAN 65.094 0.0485661 0.89598 DMBT1 - Deleted in malignant brain tumors 1 protein precursor - Homo sapiens (Human) - DMBT1 gene May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. Indicus|evm.model.CM009516.1.375 A6NFZ4 FA24A_HUMAN 48.485 0.705426 1.22857 FAM24A - Protein FAM24A precursor - Homo sapiens (Human) - FAM24A gene Indicus|evm.model.CM009516.1.376 Q9H8K7 PAAT_HUMAN 74.607 0.995516 1.00225 PAAT - ATPase PAAT - Homo sapiens (Human) - PAAT gene ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). Indicus|evm.model.CM009516.1.377 A6NFZ4 FA24A_HUMAN 50.980 0.949495 0.942857 FAM24A - Protein FAM24A precursor - Homo sapiens (Human) - FAM24A gene Indicus|evm.model.CM009516.1.378 Q9H8K7 PAAT_HUMAN 74.376 0.990991 0.997753 PAAT - ATPase PAAT - Homo sapiens (Human) - PAAT gene ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). Indicus|evm.model.CM009516.1.379 Q8IV42 PSTK_HUMAN 77.966 0.818942 1.03161 PSTK - L-seryl-tRNA(Sec) kinase - Homo sapiens (Human) - PSTK gene Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. Indicus|evm.model.CM009516.1.380 A4IFJ6 IKZF5_BOVIN 100.000 0.995238 1.00239 IKZF5 - Zinc finger protein Pegasus - Bos taurus (Bovine) - IKZF5 gene DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor (By similarity). Indicus|evm.model.CM009516.1.381 Q5EAD4 ACDSB_BOVIN 100.000 0.995381 1.00231 ACADSB - Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACADSB gene Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (By similarity). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway (By similarity). Can also act on valproyl-CoA, a metabolite of the valproic acid drug (By similarity). Indicus|evm.model.CM009516.1.382 A6NHT5 HMX3_HUMAN 98.050 0.994444 1.0084 HMX3 - Homeobox protein HMX3 - Homo sapiens (Human) - HMX3 gene Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). Indicus|evm.model.CM009516.1.383 P43687 HMX2_MOUSE 94.891 0.992727 1.00733 Hmx2 - Homeobox protein HMX2 - Mus musculus (Mouse) - Hmx2 gene Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Indicus|evm.model.CM009516.1.384 O43684 BUB3_HUMAN 100.000 0.993921 1.00305 BUB3 - Mitotic checkpoint protein BUB3 - Homo sapiens (Human) - BUB3 gene Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Indicus|evm.model.CM009516.1.386 Q8NDV2 GPR26_HUMAN 98.551 0.299559 0.673591 GPR26 - G-protein coupled receptor 26 - Homo sapiens (Human) - GPR26 gene Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. Indicus|evm.model.CM009516.1.387 Q9D2L5 CPXM2_MOUSE 94.809 0.987915 0.866492 Cpxm2 - Inactive carboxypeptidase-like protein X2 precursor - Mus musculus (Mouse) - Cpxm2 gene May be involved in cell-cell interactions. Indicus|evm.model.CM009516.1.388 Q7LFX5 CHSTF_HUMAN 90.731 0.996441 1.00178 CHST15 - Carbohydrate sulfotransferase 15 - Homo sapiens (Human) - CHST15 gene Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo. Indicus|evm.model.CM009516.1.390 Q3ZCF5 OAT_BOVIN 99.772 0.995455 1.00228 OAT - Ornithine aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - OAT gene mitochondrial matrix, identical protein binding Indicus|evm.model.CM009516.1.391 P15858 EMS_APIME 92.982 0.231405 3.27027 Homeobox protein H40 - Apis mellifera (Honeybee) Indicus|evm.model.CM009516.1.392 Q0VD18 LHPP_BOVIN 100.000 0.99262 1.0037 LHPP - Phospholysine phosphohistidine inorganic pyrophosphate phosphatase - Bos taurus (Bovine) - LHPP gene Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency. Indicus|evm.model.CM009516.1.394 Q14153 FA53B_HUMAN 59.836 0.761194 0.317536 FAM53B - Protein FAM53B - Homo sapiens (Human) - FAM53B gene Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. Indicus|evm.model.CM009516.1.395 Q14153 FA53B_HUMAN 73.355 0.592213 1.1564 FAM53B - Protein FAM53B - Homo sapiens (Human) - FAM53B gene Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. Indicus|evm.model.CM009516.1.396 Q5JPI9 EFMT2_HUMAN 91.146 0.805907 0.814433 EEF1AKMT2 - EEF1A lysine methyltransferase 2 - Homo sapiens (Human) - EEF1AKMT2 gene Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. Indicus|evm.model.CM009516.1.397 A6QLR3 ABRX2_BOVIN 99.755 0.957647 1.03912 ABRAXAS2 - BRISC complex subunit Abraxas 2 - Bos taurus (Bovine) - ABRAXAS2 gene Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (By similarity). Indicus|evm.model.CM009516.1.398 A6QP16 ZRAN1_BOVIN 100.000 0.960598 1.03955 ZRANB1 - Ubiquitin thioesterase ZRANB1 - Bos taurus (Bovine) - ZRANB1 gene Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity). Indicus|evm.model.CM009516.1.399 Q0VCQ1 CTBP2_BOVIN 100.000 0.995516 1.00225 CTBP2 - C-terminal-binding protein 2 - Bos taurus (Bovine) - CTBP2 gene Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses. Indicus|evm.model.CM009516.1.401 Q4R7H5 EF1G_MACFA 72.414 0.966292 0.203661 EEF1G - Elongation factor 1-gamma - Macaca fascicularis (Crab-eating macaque) - EEF1G gene Probably plays a role in anchoring the complex to other cellular components. Indicus|evm.model.CM009516.1.402 Q5VZQ5 TEX36_HUMAN 79.891 0.958115 1.02688 TEX36 - Testis-expressed protein 36 - Homo sapiens (Human) - TEX36 gene Indicus|evm.model.CM009516.1.403 Q3B7T1 EDRF1_HUMAN 95.514 0.989499 1 EDRF1 - Erythroid differentiation-related factor 1 - Homo sapiens (Human) - EDRF1 gene Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene. Indicus|evm.model.CM009516.1.404 P10746 HEM4_HUMAN 85.985 0.755747 1.31321 UROS - Uroporphyrinogen-III synthase - Homo sapiens (Human) - UROS gene Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). Indicus|evm.model.CM009516.1.405 Q2NL37 BCCIP_BOVIN 100.000 0.993485 1.00327 BCCIP - BRCA2 and CDKN1A-interacting protein - Bos taurus (Bovine) - BCCIP gene During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). Indicus|evm.model.CM009516.1.406 Q7L7V1 DHX32_HUMAN 88.993 0.997315 1.00269 DHX32 - Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 - Homo sapiens (Human) - DHX32 gene spliceosomal complex, RNA binding Indicus|evm.model.CM009516.1.407 Q3ZC82 ZC3HE_BOVIN 96.610 0.123142 0.640816 ZC3H14 - Zinc finger CCCH domain-containing protein 14 - Bos taurus (Bovine) - ZC3H14 gene Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides. Indicus|evm.model.CM009516.1.408 Q6B858 FANK1_BOVIN 99.413 0.991254 0.994203 FANK1 - Fibronectin type 3 and ankyrin repeat domains protein 1 - Bos taurus (Bovine) - FANK1 gene Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. Indicus|evm.model.CM009516.1.409 O43184 ADA12_HUMAN 79.449 0.979823 0.872387 ADAM12 - Disintegrin and metalloproteinase domain-containing protein 12 precursor - Homo sapiens (Human) - ADAM12 gene Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). Indicus|evm.model.CM009516.1.410 Q96M02 CJ090_HUMAN 82.199 0.272206 0.998569 C10orf90 - (E2-independent) E3 ubiquitin-conjugating enzyme FATS - Homo sapiens (Human) - C10orf90 gene Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable). Indicus|evm.model.CM009516.1.411 Q14185 DOCK1_HUMAN 97.487 0.998884 0.960858 DOCK1 - Dedicator of cytokinesis protein 1 - Homo sapiens (Human) - DOCK1 gene Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). Indicus|evm.model.CM009516.1.412 Q6ZQN5 FOXI2_HUMAN 77.044 0.99361 0.984277 FOXI2 - Forkhead box protein I2 - Homo sapiens (Human) - FOXI2 gene Possible transcriptional activator. Indicus|evm.model.CM009516.1.413 Q8NCR9 CLRN3_HUMAN 73.799 0.991304 1.0177 CLRN3 - Clarin-3 - Homo sapiens (Human) - CLRN3 gene extracellular exosome Indicus|evm.model.CM009516.1.416 P23469 PTPRE_HUMAN 92.635 0.975104 1.03286 PTPRE - Receptor-type tyrosine-protein phosphatase epsilon precursor - Homo sapiens (Human) - PTPRE gene Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Indicus|evm.model.CM009516.1.420 Q5ZKH0 TF2H5_CHICK 75.000 0.314516 1.74648 GTF2H5 - General transcription factor IIH subunit 5 - Gallus gallus (Chicken) - GTF2H5 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Indicus|evm.model.CM009516.1.430 Q6TDU1 MGMT_CANLF 72.986 0.990566 0.981481 MGMT - Methylated-DNA--protein-cysteine methyltransferase - Canis lupus familiaris (Dog) - MGMT gene Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Indicus|evm.model.CM009516.1.432 O08791 COE3_MOUSE 80.942 0.881466 0.778523 Ebf3 - Transcription factor COE3 - Mus musculus (Mouse) - Ebf3 gene Transcriptional activator (PubMed:9151732). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). Indicus|evm.model.CM009516.1.434 Q9H4W6 COE3_HUMAN 95.960 0.372624 0.441275 EBF3 - Transcription factor COE3 - Homo sapiens (Human) - EBF3 gene Transcriptional activator (PubMed:28017373, PubMed:28017372, PubMed:28017370). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). Indicus|evm.model.CM009516.1.436 A0A1B0GUT2 CJ143_HUMAN 60.000 0.973214 1.03704 C10orf143 - Uncharacterized protein C10orf143 - Homo sapiens (Human) - C10orf143 gene Indicus|evm.model.CM009516.1.437 Q58DA7 GLRX3_BOVIN 99.672 0.771574 1.17964 GLRX3 - Glutaredoxin-3 - Bos taurus (Bovine) - GLRX3 gene Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). Indicus|evm.model.CM009516.1.448 Q5VWI1 TCRGL_HUMAN 98.361 0.737805 0.279863 TCERG1L - Transcription elongation regulator 1-like protein - Homo sapiens (Human) - TCERG1L gene nucleus, RNA polymerase binding, transcription coregulator activity Indicus|evm.model.CM009516.1.449 Q5BIR5 SPB8_BOVIN 80.822 0.972973 0.197861 SERPINB8 - Serpin B8 - Bos taurus (Bovine) - SERPINB8 gene Has an important role in epithelial desmosome-mediated cell-cell adhesion. Indicus|evm.model.CM009516.1.450 Q32LK9 SYCE1_BOVIN 100.000 0.993827 1.0031 SYCE1 - Synaptonemal complex central element protein 1 - Bos taurus (Bovine) - SYCE1 gene Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. Indicus|evm.model.CM009516.1.451 O18963 CP2E1_BOVIN 100.000 0.995968 1.00202 CYP2E1 - Cytochrome P450 2E1 - Bos taurus (Bovine) - CYP2E1 gene A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. Indicus|evm.model.CM009516.1.453 Q5VWI1 TCRGL_HUMAN 48.421 0.304965 0.481229 TCERG1L - Transcription elongation regulator 1-like protein - Homo sapiens (Human) - TCERG1L gene nucleus, RNA polymerase binding, transcription coregulator activity Indicus|evm.model.CM009516.1.454 Q0KK55 KNDC1_MOUSE 86.842 0.0572838 1.5132 Kndc1 - Kinase non-catalytic C-lobe domain-containing protein 1 - Mus musculus (Mouse) - Kndc1 gene RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (PubMed:17984326, PubMed:21385318). May be involved in cellular senescence (By similarity). Indicus|evm.model.CM009516.1.456 Q8IYW2 CFA46_HUMAN 68.614 0.954916 0.947698 CFAP46 - Cilia- and flagella-associated protein 46 - Homo sapiens (Human) - CFAP46 gene As part of the central apparatus of the cilium axoneme plays a role in cilium movement. Indicus|evm.model.CM009516.1.457 Q9C056 NKX62_HUMAN 89.552 0.956522 0.249097 NKX6-2 - Homeobox protein Nkx-6.2 - Homo sapiens (Human) - NKX6-2 gene Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions. Indicus|evm.model.CM009516.1.458 Q29467 I5P1_CANLF 94.286 0.29806 1.37621 INPP5A - Inositol polyphosphate-5-phosphatase A precursor - Canis lupus familiaris (Dog) - INPP5A gene Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8198557). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity). Indicus|evm.model.CM009516.1.459 Q14642 I5P1_HUMAN 93.750 0.0784558 1.94903 INPP5A - Inositol polyphosphate-5-phosphatase A precursor - Homo sapiens (Human) - INPP5A gene Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8769125, PubMed:8626616). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity). Indicus|evm.model.CM009516.1.462 Q66LE6 2ABD_HUMAN 45.690 0.318792 1.31567 PPP2R2D - Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform - Homo sapiens (Human) - PPP2R2D gene B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Indicus|evm.model.CM009516.1.463 Q32KN2 BNIP3_BOVIN 99.448 0.44226 2.07653 BNIP3 - BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 - Bos taurus (Bovine) - BNIP3 gene Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway (By similarity). Indicus|evm.model.CM009516.1.465 Q5VZ66 JKIP3_HUMAN 87.015 0.674009 1.34479 JAKMIP3 - Janus kinase and microtubule-interacting protein 3 - Homo sapiens (Human) - JAKMIP3 gene Indicus|evm.model.CM009516.1.466 Q62951 DPYL4_RAT 92.199 0.982548 1.01596 Dpysl4 - Dihydropyrimidinase-related protein 4 - Rattus norvegicus (Rat) - Dpysl4 gene Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Indicus|evm.model.CM009516.1.467 Q86UX6 ST32C_HUMAN 83.906 0.637143 1.44033 STK32C - Serine/threonine-protein kinase 32C - Homo sapiens (Human) - STK32C gene protein serine/threonine kinase activity, intracellular signal transduction, peptidyl-serine phosphorylation Indicus|evm.model.CM009516.1.468 Q9C0I9 LRC27_HUMAN 56.679 0.996047 0.954717 LRRC27 - Leucine-rich repeat-containing protein 27 - Homo sapiens (Human) - LRRC27 gene Indicus|evm.model.CM009516.1.469 Q6NUJ5 PWP2B_HUMAN 74.566 0.647173 0.869492 PWWP2B - PWWP domain-containing protein 2B - Homo sapiens (Human) - PWWP2B gene nucleoplasm Indicus|evm.model.CM009517.1.1 Q8BJ42 DLGP2_MOUSE 86.111 0.752101 0.22474 Dlgap2 - Disks large-associated protein 2 - Mus musculus (Mouse) - Dlgap2 gene May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Indicus|evm.model.CM009517.1.3 Q8BJ42 DLGP2_MOUSE 91.597 0.983333 0.113314 Dlgap2 - Disks large-associated protein 2 - Mus musculus (Mouse) - Dlgap2 gene May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Indicus|evm.model.CM009517.1.6 Q6AYM9 CLN8_RAT 77.717 0.356031 1.78472 Cln8 - Protein CLN8 - Rattus norvegicus (Rat) - Cln8 gene Could play a role in cell proliferation during neuronal differentiation and in protection against cell death. Indicus|evm.model.CM009517.1.7 Q96PZ7 CSMD1_HUMAN 85.151 0.914894 0.131874 CSMD1 - CUB and sushi domain-containing protein 1 precursor - Homo sapiens (Human) - CSMD1 gene Potential suppressor of squamous cell carcinomas. Indicus|evm.model.CM009517.1.8 O15013 ARHGA_HUMAN 77.737 0.998536 0.997809 ARHGEF10 - Rho guanine nucleotide exchange factor 10 - Homo sapiens (Human) - ARHGEF10 gene May play a role in developmental myelination of peripheral nerves. Indicus|evm.model.CM009517.1.10 O94819 KBTBB_HUMAN 79.326 0.813433 0.860353 KBTBD11 - Kelch repeat and BTB domain-containing protein 11 - Homo sapiens (Human) - KBTBD11 gene Indicus|evm.model.CM009517.1.11 P54296 MYOM2_HUMAN 88.941 0.633098 1.15904 MYOM2 - Myomesin-2 - Homo sapiens (Human) - MYOM2 gene Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. Indicus|evm.model.CM009517.1.16 Q96PZ7 CSMD1_HUMAN 78.884 0.99415 0.815376 CSMD1 - CUB and sushi domain-containing protein 1 precursor - Homo sapiens (Human) - CSMD1 gene Potential suppressor of squamous cell carcinomas. Indicus|evm.model.CM009517.1.17 Q923L3 CSMD1_MOUSE 94.595 0.811111 0.0252525 Csmd1 - CUB and sushi domain-containing protein 1 precursor - Mus musculus (Mouse) - Csmd1 gene conditioned place preference, female gonad development, glucose homeostasis, male gonad development, mammary gland branching involved in pregnancy, memory, oviduct epithelium development, startle response Indicus|evm.model.CM009517.1.19 Q96PZ7 CSMD1_HUMAN 95.714 0.599138 0.0650954 CSMD1 - CUB and sushi domain-containing protein 1 precursor - Homo sapiens (Human) - CSMD1 gene Potential suppressor of squamous cell carcinomas. Indicus|evm.model.CM009517.1.21 Q923L3 CSMD1_MOUSE 98.630 0.626087 0.0322671 Csmd1 - CUB and sushi domain-containing protein 1 precursor - Mus musculus (Mouse) - Csmd1 gene conditioned place preference, female gonad development, glucose homeostasis, male gonad development, mammary gland branching involved in pregnancy, memory, oviduct epithelium development, startle response Indicus|evm.model.CM009517.1.23 P49449 CENPA_BOVIN 97.826 0.985507 1 CENPA - Histone H3-like centromeric protein A - Bos taurus (Bovine) - CENPA gene Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis. Indicus|evm.model.CM009517.1.24 Q9JLR9 HIG1A_MOUSE 81.720 0.978723 0.989474 Higd1a - HIG1 domain family member 1A, mitochondrial - Mus musculus (Mouse) - Higd1a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Indicus|evm.model.CM009517.1.25 B2RYG6 OTUB1_RAT 75.325 0.656652 0.859779 Otub1 - Ubiquitin thioesterase OTUB1 - Rattus norvegicus (Rat) - Otub1 gene Hydrolase that can specifically remove compared to 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (By similarity). Indicus|evm.model.CM009517.1.27 P61593 MCPH1_PANTR 58.901 0.989273 1.00479 MCPH1 - Microcephalin - Pan troglodytes (Chimpanzee) - MCPH1 gene Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity). Indicus|evm.model.CM009517.1.28 Q9NUQ2 PLCE_HUMAN 84.658 0.994536 1.00549 AGPAT5 - 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon - Homo sapiens (Human) - AGPAT5 gene Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed:21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed:21173190). Indicus|evm.model.CM009517.1.29 Q6UX68 XKR5_HUMAN 65.512 0.881737 0.973761 XKR5 - XK-related protein 5 - Homo sapiens (Human) - XKR5 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Indicus|evm.model.CM009517.1.31 Q95M67 DEFB1_CERER 59.615 0.31677 2.36765 DEFB1 - Beta-defensin 1 precursor - Cercopithecus erythrogaster (Red-bellied monkey) - DEFB1 gene Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. Indicus|evm.model.CM009517.1.32 Q0W9P9 D103A_HORSE 80.597 0.970588 1.01493 DEFB103A - Beta-defensin 103A precursor - Equus caballus (Horse) - DEFB103A gene Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria. Indicus|evm.model.CM009517.1.33 Q8TC21 ZN596_HUMAN 59.204 0.696864 0.569444 ZNF596 - Zinc finger protein 596 - Homo sapiens (Human) - ZNF596 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009517.1.35 Q08050 FOXM1_HUMAN 77.536 0.728723 0.246396 FOXM1 - Forkhead box protein M1 - Homo sapiens (Human) - FOXM1 gene Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. Indicus|evm.model.CM009517.1.37 A3RJ36 LAP_BUBBU 83.721 0.375 1.75 Lingual antimicrobial peptide precursor - Bubalus bubalis (Domestic water buffalo) Indicus|evm.model.CM009517.1.41 Q95M67 DEFB1_CERER 56.716 0.942857 1.02941 DEFB1 - Beta-defensin 1 precursor - Cercopithecus erythrogaster (Red-bellied monkey) - DEFB1 gene Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. Indicus|evm.model.CM009517.1.48 Q95M67 DEFB1_CERER 56.716 0.942857 1.02941 DEFB1 - Beta-defensin 1 precursor - Cercopithecus erythrogaster (Red-bellied monkey) - DEFB1 gene Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. Indicus|evm.model.CM009517.1.51 Q5R9Q3 GPM6A_PONAB 82.642 0.78 1.07914 GPM6A - Neuronal membrane glycoprotein M6-a - Pongo abelii (Sumatran orangutan) - GPM6A gene Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor (By similarity). Indicus|evm.model.CM009517.1.52 Q95M67 DEFB1_CERER 58.209 0.942857 1.02941 DEFB1 - Beta-defensin 1 precursor - Cercopithecus erythrogaster (Red-bellied monkey) - DEFB1 gene Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. Indicus|evm.model.CM009517.1.53 Q8IZU2 WDR17_HUMAN 86.990 0.987241 0.948563 WDR17 - WD repeat-containing protein 17 - Homo sapiens (Human) - WDR17 gene Indicus|evm.model.CM009517.1.54 Q8K3V1 SPAT4_MOUSE 69.521 0.82153 1.19661 Spata4 - Spermatogenesis-associated protein 4 - Mus musculus (Mouse) - Spata4 gene May play a role in apoptosis regulation. Indicus|evm.model.CM009517.1.55 Q17QS6 ASB5_BOVIN 100.000 0.993939 1.00304 ASB5 - Ankyrin repeat and SOCS box protein 5 - Bos taurus (Bovine) - ASB5 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity). Indicus|evm.model.CM009517.1.56 Q6ZWQ7 SPCS3_MOUSE 83.942 0.98374 0.683333 Spcs3 - Signal peptidase complex subunit 3 - Mus musculus (Mouse) - Spcs3 gene Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Indicus|evm.model.CM009517.1.57 P49767 VEGFC_HUMAN 88.649 0.994609 0.885442 VEGFC - Vascular endothelial growth factor C precursor - Homo sapiens (Human) - VEGFC gene Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. Indicus|evm.model.CM009517.1.59 Q3SYW6 EIF3C_BOVIN 88.546 0.940928 0.259868 EIF3C - Eukaryotic translation initiation factor 3 subunit C - Bos taurus (Bovine) - EIF3C gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Indicus|evm.model.CM009517.1.60 Q3MHN7 NEIL3_BOVIN 98.007 0.97695 0.930693 NEIL3 - Endonuclease 8-like 3 - Bos taurus (Bovine) - NEIL3 gene DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (By similarity). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (By similarity). Indicus|evm.model.CM009517.1.61 P20933 ASPG_HUMAN 82.622 0.942363 1.00289 AGA - N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase precursor - Homo sapiens (Human) - AGA gene Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. Indicus|evm.model.CM009517.1.64 Q9P273 TEN3_HUMAN 98.378 0.943806 0.290107 TENM3 - Teneurin-3 - Homo sapiens (Human) - TENM3 gene Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. Indicus|evm.model.CM009517.1.65 P32321 DCTD_HUMAN 92.697 0.988827 1.00562 DCTD - Deoxycytidylate deaminase - Homo sapiens (Human) - DCTD gene Supplies the nucleotide substrate for thymidylate synthetase. Indicus|evm.model.CM009517.1.66 Q6AWC2 WWC2_HUMAN 85.640 0.977119 0.989933 WWC2 - Protein WWC2 - Homo sapiens (Human) - WWC2 gene cytosol, kinase binding, molecular adaptor activity, negative regulation of hippo signaling, negative regulation of organ growth, negative regulation of transcription by RNA polymerase II Indicus|evm.model.CM009517.1.67 Q8N7P3 CLD22_HUMAN 81.356 0.98324 0.813636 CLDN22 - Claudin-22 - Homo sapiens (Human) - CLDN22 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009517.1.68 A6NM45 CLD24_HUMAN 82.273 0.99095 1.00455 CLDN24 - Putative claudin-24 - Homo sapiens (Human) - CLDN24 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009517.1.69 Q3SZL8 CNDH2_BOVIN 57.210 0.991781 0.586817 NCAPH2 - Condensin-2 complex subunit H2 - Bos taurus (Bovine) - NCAPH2 gene Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (By similarity). Indicus|evm.model.CM009517.1.70 Q9NXV6 CARF_HUMAN 89.384 0.996558 1.00172 CDKN2AIP - CDKN2A-interacting protein - Homo sapiens (Human) - CDKN2AIP gene Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. Indicus|evm.model.CM009517.1.71 Q9ESK4 ING2_MOUSE 97.173 0.992958 1.01068 Ing2 - Inhibitor of growth protein 2 - Mus musculus (Mouse) - Ing2 gene Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity). Indicus|evm.model.CM009517.1.72 Q6NW29 RWDD4_HUMAN 95.213 0.989418 1.00532 RWDD4 - RWD domain-containing protein 4 - Homo sapiens (Human) - RWDD4 gene Indicus|evm.model.CM009517.1.73 A6QLC7 TPC11_BOVIN 99.735 0.998236 1.00088 TRAPPC11 - Trafficking protein particle complex subunit 11 - Bos taurus (Bovine) - TRAPPC11 gene Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Indicus|evm.model.CM009517.1.75 Q9P2F5 STOX2_HUMAN 94.708 0.997843 1.00108 STOX2 - Storkhead-box protein 2 - Homo sapiens (Human) - STOX2 gene embryo development ending in birth or egg hatching, maternal placenta development Indicus|evm.model.CM009517.1.76 F1N5C8 ENPP6_BOVIN 99.551 0.995516 1.00225 ENPP6 - Glycerophosphocholine choline phosphodiesterase ENPP6 precursor - Bos taurus (Bovine) - ENPP6 gene Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:23161088). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity). Indicus|evm.model.CM009517.1.77 P23906 IRF2_MOUSE 92.241 0.991429 1.00287 Irf2 - Interferon regulatory factor 2 - Mus musculus (Mouse) - Irf2 gene Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Indicus|evm.model.CM009517.1.79 Q08DY9 CASP3_BOVIN 99.273 0.985612 1.01091 CASP3 - Caspase-3 precursor - Bos taurus (Bovine) - CASP3 gene Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Indicus|evm.model.CM009517.1.80 Q08DZ8 PRIPO_BOVIN 99.279 0.996403 1.0018 PRIMPOL - DNA-directed primase/polymerase protein - Bos taurus (Bovine) - PRIMPOL gene DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as ultraviolet (UV) lesions, R-loops and G-quadruplexes, to allow DNA replication to continue. Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion. Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase. Also required for reinitiating stalled forks after UV damage during nuclear DNA replication. Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides (By similarity). Prevents APOBEC family-mediated DNA mutagenesis by repriming downstream of abasic site to prohibit error-prone translesion synthesis (By similarity). Has non-overlapping function with POLH. In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (By similarity). Indicus|evm.model.CM009517.1.81 Q2KIW5 CENPU_BOVIN 90.196 0.992021 0.921569 CENPU - Centromere protein U - Bos taurus (Bovine) - CENPU gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity). Indicus|evm.model.CM009517.1.82 P33121 ACSL1_HUMAN 90.258 0.995714 1.00287 ACSL1 - Long-chain-fatty-acid--CoA ligase 1 - Homo sapiens (Human) - ACSL1 gene Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity). Indicus|evm.model.CM009517.1.83 A6NFD8 HELT_HUMAN 93.388 0.99177 1.00413 HELT - Hairy and enhancer of split-related protein HELT - Homo sapiens (Human) - HELT gene Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Indicus|evm.model.CM009517.1.84 Q8VEA4 MIA40_MOUSE 54.430 0.462121 0.94964 Chchd4 - Mitochondrial intermembrane space import and assembly protein 40 - Mus musculus (Mouse) - Chchd4 gene Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (PubMed:26004228). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake. Indicus|evm.model.CM009517.1.85 P02722 ADT1_BOVIN 100.000 0.993311 1.00336 SLC25A4 - ADP/ATP translocase 1 - Bos taurus (Bovine) - SLC25A4 gene ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (PubMed:7961643). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (PubMed:7961643). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). Indicus|evm.model.CM009517.1.86 Q2KJH5 CFA97_BOVIN 99.810 0.996212 1.0019 CFAP97 - Cilia- and flagella-associated protein 97 - Bos taurus (Bovine) - CFAP97 gene Indicus|evm.model.CM009517.1.87 Q9H3E2 SNX25_HUMAN 92.157 0.911695 0.997619 SNX25 - Sorting nexin-25 - Homo sapiens (Human) - SNX25 gene May be involved in several stages of intracellular trafficking. Indicus|evm.model.CM009517.1.88 Q4R3N2 LR2BP_MACFA 91.954 0.994269 1.00287 LRP2BP - LRP2-binding protein - Macaca fascicularis (Crab-eating macaque) - LRP2BP gene May act as an adapter that regulates LRP2 function. Indicus|evm.model.CM009517.1.89 Q0VC93 ANR37_BOVIN 100.000 0.785 1.26582 ANKRD37 - Ankyrin repeat domain-containing protein 37 - Bos taurus (Bovine) - ANKRD37 gene Indicus|evm.model.CM009517.1.90 Q9NUQ7 UFSP2_HUMAN 93.390 0.995745 1.00213 UFSP2 - Ufm1-specific protease 2 - Homo sapiens (Human) - UFSP2 gene Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins (PubMed:25219498, PubMed:32160526). Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (PubMed:25219498). Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (PubMed:25219498). Indicus|evm.model.CM009517.1.91 Q2T9M0 CD047_BOVIN 99.353 0.993548 1.00324 UPF0602 protein C4orf47 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009517.1.92 Q95JS9 CC110_MACFA 77.910 0.979953 1.01801 CCDC110 - Coiled-coil domain-containing protein 110 - Macaca fascicularis (Crab-eating macaque) - CCDC110 gene Indicus|evm.model.CM009517.1.93 Q6QGC0 PDLI3_PIG 96.438 0.994521 1 PDLIM3 - PDZ and LIM domain protein 3 - Sus scrofa (Pig) - PDLIM3 gene May play a role in the organization of actin filament arrays within muscle cells. Indicus|evm.model.CM009517.1.94 O94875 SRBS2_HUMAN 92.920 0.294737 0.345455 SORBS2 - Sorbin and SH3 domain-containing protein 2 - Homo sapiens (Human) - SORBS2 gene Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. Indicus|evm.model.CM009517.1.95 P28220 SRBS2_PIG 95.683 0.252747 3.4557 SORBS2 - Sorbin and SH3 domain-containing protein 2 - Sus scrofa (Pig) - SORBS2 gene Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Increases water and sodium absorption in the intestine and gall-bladder. Indicus|evm.model.CM009517.1.96 Q5TJ59 TLR3_BOVIN 99.226 0.99779 1.00111 TLR3 - Toll-like receptor 3 precursor - Bos taurus (Bovine) - TLR3 gene Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity). Indicus|evm.model.CM009517.1.97 A5PLN7 F149A_HUMAN 62.271 0.997439 1.01035 FAM149A - Protein FAM149A - Homo sapiens (Human) - FAM149A gene Indicus|evm.model.CM009517.1.98 Q5RCN6 CP4V2_PONAB 77.947 0.994318 1.00571 CYP4V2 - Cytochrome P450 4V2 - Pongo abelii (Sumatran orangutan) - CYP4V2 gene A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.CM009517.1.99 Q2KJ63 KLKB1_BOVIN 99.686 0.967988 1.03145 KLKB1 - Plasma kallikrein precursor - Bos taurus (Bovine) - KLKB1 gene The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin (By similarity). Indicus|evm.model.CM009517.1.100 Q5NTB3 FA11_BOVIN 99.680 0.996805 1.0016 F11 - Coagulation factor XI precursor - Bos taurus (Bovine) - F11 gene Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Indicus|evm.model.CM009517.1.101 O02769 MTR1A_BOVIN 98.833 0.697548 1.42802 MTNR1A - Melatonin receptor type 1A - Bos taurus (Bovine) - MTNR1A gene High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Indicus|evm.model.CM009517.1.102 Q14517 FAT1_HUMAN 89.930 0.999564 1.00022 FAT1 - Protocadherin Fat 1 precursor - Homo sapiens (Human) - FAT1 gene Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. Indicus|evm.model.CM009517.1.103 P62859 RS28_RAT 86.957 0.967742 0.898551 Rps28 - 40S ribosomal protein S28 - Rattus norvegicus (Rat) - Rps28 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, maturation of SSU-rRNA, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis Indicus|evm.model.CM009517.1.105 Q8ST83 PHO_DROME 67.769 0.4 0.576923 pho - Polycomb protein PHO - Drosophila melanogaster (Fruit fly) - pho gene Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression. Indicus|evm.model.CM009517.1.106 Q8N7C3 TRIMM_HUMAN 61.183 0.867882 1.13437 TRIML2 - Probable E3 ubiquitin-protein ligase TRIML2 - Homo sapiens (Human) - TRIML2 gene cytoplasm, cytosol, nucleoplasm, identical protein binding, protein homodimerization activity, protein kinase binding, ubiquitin protein ligase activity, innate immune response, positive regulation of autophagy, positive regulation of I-kappaB kinase/NF-kappaB signaling Indicus|evm.model.CM009517.1.107 Q8N9V2 TRIML_HUMAN 84.188 0.983158 1.01496 TRIML1 - Probable E3 ubiquitin-protein ligase TRIML1 - Homo sapiens (Human) - TRIML1 gene Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development. Indicus|evm.model.CM009517.1.108 Q9H5H4 ZN768_HUMAN 74.251 0.882979 0.348148 ZNF768 - Zinc finger protein 768 - Homo sapiens (Human) - ZNF768 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009517.1.109 Q7Z7J5 DPPA2_HUMAN 58.885 0.89557 1.0604 DPPA2 - Developmental pluripotency-associated protein 2 - Homo sapiens (Human) - DPPA2 gene Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. Indicus|evm.model.CM009517.1.110 P83917 CBX1_MOUSE 98.256 0.988439 0.935135 Cbx1 - Chromobox protein homolog 1 - Mus musculus (Mouse) - Cbx1 gene Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Indicus|evm.model.CM009517.1.111 Q14331 FRG1_HUMAN 98.837 0.992278 1.00388 FRG1 - Protein FRG1 - Homo sapiens (Human) - FRG1 gene Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Indicus|evm.model.CM009517.1.112 Q17QB3 ASAH1_BOVIN 100.000 0.994949 1.00253 ASAH1 - Acid ceramidase precursor - Bos taurus (Bovine) - ASAH1 gene Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity). Has also an N-acylethanolamine hydrolase activity (By similarity). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity). Indicus|evm.model.CM009517.1.113 Q15154 PCM1_HUMAN 85.297 0.998582 1.04496 PCM1 - Pericentriolar material 1 protein - Homo sapiens (Human) - PCM1 gene Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Involved in the biogenesis of cilia (PubMed:20551181, PubMed:24121310). Indicus|evm.model.CM009517.1.115 Q3SZZ7 FGL1_BOVIN 100.000 0.984177 1.01282 FGL1 - Fibrinogen-like protein 1 precursor - Bos taurus (Bovine) - FGL1 gene Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes. Indicus|evm.model.CM009517.1.117 Q17QT2 MTUS1_BOVIN 95.604 0.34736 2.79872 MTUS1 - Microtubule-associated tumor suppressor 1 homolog - Bos taurus (Bovine) - MTUS1 gene Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity). Indicus|evm.model.CM009517.1.118 Q5BIP2 PGFRL_BOVIN 99.733 0.994681 1.00267 PDGFRL - Platelet-derived growth factor receptor-like protein precursor - Bos taurus (Bovine) - PDGFRL gene Indicus|evm.model.CM009517.1.119 P52569 CTR2_HUMAN 91.641 0.995455 1.00304 SLC7A2 - Cationic amino acid transporter 2 - Homo sapiens (Human) - SLC7A2 gene Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. Indicus|evm.model.CM009517.1.121 Q9Y216 MTMR7_HUMAN 94.848 0.996974 1.00152 MTMR7 - Myotubularin-related protein 7 - Homo sapiens (Human) - MTMR7 gene Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2). Indicus|evm.model.CM009517.1.122 Q8NEZ2 VP37A_HUMAN 94.458 0.994975 1.00252 VPS37A - Vacuolar protein sorting-associated protein 37A - Homo sapiens (Human) - VPS37A gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Indicus|evm.model.CM009517.1.123 Q60809 CNOT7_MOUSE 100.000 0.690418 1.42807 Cnot7 - CCR4-NOT transcription complex subunit 7 - Mus musculus (Mouse) - Cnot7 gene Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA-mediated mRNA deadenylation. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. Indicus|evm.model.CM009517.1.124 Q9UIJ5 ZDHC2_HUMAN 94.769 0.93913 0.940054 ZDHHC2 - Palmitoyltransferase ZDHHC2 - Homo sapiens (Human) - ZDHHC2 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18508921, PubMed:18296695, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). Indicus|evm.model.CM009517.1.125 Q86XE3 MICU3_HUMAN 90.244 0.955801 1.02453 MICU3 - Calcium uptake protein 3, mitochondrial - Homo sapiens (Human) - MICU3 gene May play a role in mitochondrial calcium uptake. Indicus|evm.model.CM009517.1.126 Q9NP95 FGF20_HUMAN 98.104 0.990566 1.00474 FGF20 - Fibroblast growth factor 20 - Homo sapiens (Human) - FGF20 gene Neurotrophic factor that regulates central nervous development and function. Indicus|evm.model.CM009517.1.127 Q29503 UB2R2_RABIT 66.667 0.526316 0.39916 UBE2R2 - Ubiquitin-conjugating enzyme E2 R2 - Oryctolagus cuniculus (Rabbit) - UBE2R2 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin. Indicus|evm.model.CM009517.1.128 P21758 MSRE_BOVIN 89.404 0.995074 0.896247 MSR1 - Macrophage scavenger receptor types I and II - Bos taurus (Bovine) - MSR1 gene Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Indicus|evm.model.CM009517.1.129 Q5R893 H2B1_PONAB 73.016 0.979798 0.785714 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009517.1.130 Q32L57 TUSC3_BOVIN 99.712 0.994253 1.00288 TUSC3 - Tumor suppressor candidate 3 precursor - Bos taurus (Bovine) - TUSC3 gene Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Indicus|evm.model.CM009517.1.131 Q96P11 NSUN5_HUMAN 87.600 0.832776 0.69697 NSUN5 - 28S rRNA (cytosine-C(5))-methyltransferase - Homo sapiens (Human) - NSUN5 gene S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity). Indicus|evm.model.CM009517.1.132 Q96LD1 SGCZ_HUMAN 96.923 0.984615 0.217391 SGCZ - Zeta-sarcoglycan - Homo sapiens (Human) - SGCZ gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity). Indicus|evm.model.CM009517.1.133 Q96LD1 SGCZ_HUMAN 96.923 0.984733 0.438127 SGCZ - Zeta-sarcoglycan - Homo sapiens (Human) - SGCZ gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity). Indicus|evm.model.CM009517.1.135 Q9JI44 DMAP1_MOUSE 56.757 0.688679 0.226496 Dmap1 - DNA methyltransferase 1-associated protein 1 - Mus musculus (Mouse) - Dmap1 gene Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity (By similarity). Indicus|evm.model.CM009517.1.136 Q96LL4 CH048_HUMAN 65.074 0.99262 0.84953 C8orf48 - Uncharacterized protein C8orf48 - Homo sapiens (Human) - C8orf48 gene Indicus|evm.model.CM009517.1.137 A7E300 RHG07_BOVIN 99.444 0.707349 1.3705 DLC1 - Rho GTPase-activating protein 7 - Bos taurus (Bovine) - DLC1 gene Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). Indicus|evm.model.CM009517.1.138 Q99880 H2B1L_HUMAN 70.968 0.50289 1.37302 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009517.1.139 Q08DH3 TRM9B_BOVIN 99.688 0.697168 1.01325 TRMT9B - Probable tRNA methyltransferase 9B - Bos taurus (Bovine) - TRMT9B gene May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity). Indicus|evm.model.CM009517.1.141 Q17RB8 LONF1_HUMAN 84.604 0.967311 0.870634 LONRF1 - LON peptidase N-terminal domain and RING finger protein 1 - Homo sapiens (Human) - LONRF1 gene cytosol, protein polyubiquitination Indicus|evm.model.CM009517.1.143 Q86YV5 PRAG1_HUMAN 78.273 0.990774 1.00213 PRAG1 - Inactive tyrosine-protein kinase PRAG1 - Homo sapiens (Human) - PRAG1 gene Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). Indicus|evm.model.CM009517.1.144 Q9D7D7 CLD23_MOUSE 77.365 0.993197 0.993243 Cldn23 - Claudin-23 - Mus musculus (Mouse) - Cldn23 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009517.1.146 Q9Y4C4 MFHA1_HUMAN 94.389 0.996004 0.951521 MFHAS1 - Malignant fibrous histiocytoma-amplified sequence 1 - Homo sapiens (Human) - MFHAS1 gene Probable GTP-binding protein (PubMed:24286120). Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways (PubMed:26599367, PubMed:28471450, PubMed:28609714). Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (PubMed:28609714). Both inhibits and activates the TLR2-dependent signaling pathway (PubMed:26599367). Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway (PubMed:29168081). Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway (PubMed:23327923). Indicus|evm.model.CM009517.1.147 Q8IV48 ERI1_HUMAN 89.971 0.994286 1.00287 ERI1 - 3'-5' exoribonuclease 1 - Homo sapiens (Human) - ERI1 gene RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Indicus|evm.model.CM009517.1.148 A6QNP3 PPR3B_BOVIN 100.000 0.832353 1.19718 PPP1R3B - Protein phosphatase 1 regulatory subunit 3B - Bos taurus (Bovine) - PPP1R3B gene Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). Indicus|evm.model.CM009517.1.149 O95271 TNKS1_HUMAN 98.870 0.998494 1.00075 TNKS - Poly [ADP-ribose] polymerase tankyrase-1 - Homo sapiens (Human) - TNKS gene Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). Indicus|evm.model.CM009517.1.150 Q5D006 UBP11_RAT 50.467 0.75 0.138979 Usp11 - Ubiquitin carboxyl-terminal hydrolase 11 - Rattus norvegicus (Rat) - Usp11 gene Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex. Indicus|evm.model.CM009517.1.151 Q01988 UBP11_CANLF 86.395 0.637681 1.55056 USP11 - Ubiquitin carboxyl-terminal hydrolase 11 - Canis lupus familiaris (Dog) - USP11 gene Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex. Indicus|evm.model.CM009517.1.152 Q62767 DUS4_RAT 96.962 0.994937 1 Dusp4 - Dual specificity protein phosphatase 4 - Rattus norvegicus (Rat) - Dusp4 gene Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Indicus|evm.model.CM009517.1.153 Q08E24 SARAF_BOVIN 98.209 0.994048 1.00299 SARAF - Store-operated calcium entry-associated regulatory factor precursor - Bos taurus (Bovine) - SARAF gene Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions (By similarity). Indicus|evm.model.CM009517.1.154 Q32PD8 LERL1_BOVIN 100.000 0.971831 0.541985 LEPROTL1 - Leptin receptor overlapping transcript-like 1 - Bos taurus (Bovine) - LEPROTL1 gene Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). Indicus|evm.model.CM009517.1.155 Q96T53 MBOA4_HUMAN 79.540 0.995413 1.0023 MBOAT4 - Ghrelin O-acyltransferase - Homo sapiens (Human) - MBOAT4 gene Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid. Indicus|evm.model.CM009517.1.156 Q148G7 DCTN6_BOVIN 100.000 0.989529 1.00526 DCTN6 - Dynactin subunit 6 - Bos taurus (Bovine) - DCTN6 gene dynactin complex, dynein complex binding, mitotic spindle organization Indicus|evm.model.CM009517.1.157 Q5E995 RS6_BOVIN 82.967 0.988571 0.702811 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.CM009517.1.158 Q93062 RBPMS_HUMAN 95.628 0.730924 1.27041 RBPMS - RNA-binding protein with multiple splicing - Homo sapiens (Human) - RBPMS gene Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403). Indicus|evm.model.CM009517.1.160 Q2KJF9 T2EB_BOVIN 100.000 0.751131 0.764706 GTF2E2 - General transcription factor IIE subunit 2 - Bos taurus (Bovine) - GTF2E2 gene Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Indicus|evm.model.CM009517.1.161 P47791 GSHR_MOUSE 89.762 0.967667 0.866 Gsr - Glutathione reductase, mitochondrial precursor - Mus musculus (Mouse) - Gsr gene Maintains high levels of reduced glutathione in the cytosol. Indicus|evm.model.CM009517.1.162 Q2TBH5 UBXN8_BOVIN 98.909 0.992754 1.00364 UBXN8 - UBX domain-containing protein 8 - Bos taurus (Bovine) - UBXN8 gene Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction (By similarity). Indicus|evm.model.CM009517.1.163 P62716 PP2AB_RAT 99.664 0.0944356 10.178 Ppp2cb - Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform - Rattus norvegicus (Rat) - Ppp2cb gene PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Indicus|evm.model.CM009517.1.165 Q9UJV8 PURG_HUMAN 96.857 0.994302 1.01153 PURG - Purine-rich element-binding protein gamma - Homo sapiens (Human) - PURG gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, purine-rich negative regulatory element binding, RNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009517.1.166 Q14191 WRN_HUMAN 72.361 0.998575 0.980447 WRN - Werner syndrome ATP-dependent helicase - Homo sapiens (Human) - WRN gene Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation. Indicus|evm.model.CM009517.1.167 Q02297 NRG1_HUMAN 89.904 0.9613 1.00937 NRG1 - Pro-neuregulin-1, membrane-bound isoform precursor - Homo sapiens (Human) - NRG1 gene Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). Indicus|evm.model.CM009517.1.168 P13135 CPNS1_BOVIN 70.000 0.422414 0.441065 CAPNS1 - Calpain small subunit 1 - Bos taurus (Bovine) - CAPNS1 gene Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Indicus|evm.model.CM009517.1.169 Q2HJF1 RM53_BOVIN 96.364 0.509434 0.946429 MRPL53 - 39S ribosomal protein L53, mitochondrial precursor - Bos taurus (Bovine) - MRPL53 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Indicus|evm.model.CM009517.1.170 Q6A198 FUT10_BOVIN 99.372 0.995825 1.00209 FUT10 - Alpha-(1,3)-fucosyltransferase 10 - Bos taurus (Bovine) - FUT10 gene Probable fucosyltransferase. Indicus|evm.model.CM009517.1.171 Q1RML7 MAK16_BOVIN 99.664 0.993289 1 MAK16 - Protein MAK16 homolog - Bos taurus (Bovine) - MAK16 gene nucleolus, preribosome, large subunit precursor, maturation of 5.8S rRNA, maturation of LSU-rRNA Indicus|evm.model.CM009517.1.172 Q6NXR4 TTI2_HUMAN 79.921 0.996071 1.00197 TTI2 - TELO2-interacting protein 2 - Homo sapiens (Human) - TTI2 gene Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Indicus|evm.model.CM009517.1.173 Q8BP31 RN122_MOUSE 97.710 0.984848 0.851613 Rnf122 - RING finger protein 122 - Mus musculus (Mouse) - Rnf122 gene May induce necrosis and apoptosis. May play a role in cell viability (By similarity). Indicus|evm.model.CM009517.1.174 Q17QJ3 DUS26_BOVIN 100.000 0.763636 1.30332 DUSP26 - Dual specificity protein phosphatase 26 - Bos taurus (Bovine) - DUSP26 gene Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Indicus|evm.model.CM009517.1.178 F1LW30 UNC5D_RAT 96.996 0.949032 1.02615 Unc5d - Netrin receptor UNC5D precursor - Rattus norvegicus (Rat) - Unc5d gene Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity). Indicus|evm.model.CM009517.1.182 A8MYU2 KCNU1_HUMAN 86.141 0.488008 0.834639 KCNU1 - Potassium channel subfamily U member 1 - Homo sapiens (Human) - KCNU1 gene Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. Indicus|evm.model.CM009517.1.183 Q6KAR6 EXOC3_MOUSE 60.870 0.289362 0.311258 Exoc3 - Exocyst complex component 3 - Mus musculus (Mouse) - Exoc3 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Indicus|evm.model.CM009517.1.185 Q8IXU6 S35F2_HUMAN 83.505 0.476744 0.459893 SLC35F2 - Solute carrier family 35 member F2 - Homo sapiens (Human) - SLC35F2 gene Putative solute transporter. Indicus|evm.model.CM009517.1.188 Q9H7S9 ZN703_HUMAN 93.976 0.866906 0.471186 ZNF703 - Zinc finger protein 703 - Homo sapiens (Human) - ZNF703 gene Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. Indicus|evm.model.CM009517.1.189 Q1RMU4 ERLN2_BOVIN 100.000 0.9941 1.00296 ERLIN2 - Erlin-2 - Bos taurus (Bovine) - ERLIN2 gene Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). Indicus|evm.model.CM009517.1.190 Q3T0G5 PLPHP_BOVIN 100.000 0.992701 1.00366 PLPBP - Pyridoxal phosphate homeostasis protein - Bos taurus (Bovine) - PLPBP gene Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. Indicus|evm.model.CM009517.1.192 Q96PE1 AGRA2_HUMAN 84.651 0.634586 0.49701 ADGRA2 - Adhesion G protein-coupled receptor A2 precursor - Homo sapiens (Human) - ADGRA2 gene Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). Indicus|evm.model.CM009517.1.193 Q29S07 BRF2_BOVIN 99.762 0.995261 1.00238 BRF2 - Transcription factor IIIB 50 kDa subunit - Bos taurus (Bovine) - BRF2 gene General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress. Indicus|evm.model.CM009517.1.194 Q96PE1 AGRA2_HUMAN 94.393 0.909091 0.263079 ADGRA2 - Adhesion G protein-coupled receptor A2 precursor - Homo sapiens (Human) - ADGRA2 gene Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). Indicus|evm.model.CM009517.1.195 Q3B7T9 RFIP1_RAT 84.348 0.0933661 1.88426 Rab11fip1 - Rab11 family-interacting protein 1 - Rattus norvegicus (Rat) - Rab11fip1 gene A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and phagocytosis (By similarity). Indicus|evm.model.CM009517.1.196 Q2T9S8 AATC2_BOVIN 100.000 0.995098 1.00246 GOT1L1 - Putative aspartate aminotransferase, cytoplasmic 2 - Bos taurus (Bovine) - GOT1L1 gene cytosol, L-aspartate:2-oxoglutarate aminotransferase activity, aspartate biosynthetic process Indicus|evm.model.CM009517.1.197 P46626 ADRB3_BOVIN 100.000 0.995 0.987654 ADRB3 - Beta-3 adrenergic receptor - Bos taurus (Bovine) - ADRB3 gene Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. Indicus|evm.model.CM009517.1.198 Q0P5A7 4EBP1_BOVIN 100.000 0.983193 1.00847 EIF4EBP1 - Eukaryotic translation initiation factor 4E-binding protein 1 - Bos taurus (Bovine) - EIF4EBP1 gene Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Indicus|evm.model.CM009517.1.199 Q9UBL3 ASH2L_HUMAN 96.184 0.996825 1.00318 ASH2L - Set1/Ash2 histone methyltransferase complex subunit ASH2 - Homo sapiens (Human) - ASH2L gene Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). Indicus|evm.model.CM009517.1.200 Q28918 STAR_BOVIN 99.649 0.993007 1.00351 STAR - Steroidogenic acute regulatory protein, mitochondrial precursor - Bos taurus (Bovine) - STAR gene Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). Indicus|evm.model.CM009517.1.201 Q5E9Z8 LSM1_BOVIN 100.000 0.985075 1.00752 LSM1 - U6 snRNA-associated Sm-like protein LSm1 - Bos taurus (Bovine) - LSM1 gene Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). Indicus|evm.model.CM009517.1.202 Q8NEB5 PLPP5_HUMAN 84.706 0.954887 1.00758 PLPP5 - Phospholipid phosphatase 5 - Homo sapiens (Human) - PLPP5 gene Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules (PubMed:17590538). Indicus|evm.model.CM009517.1.203 Q9BZ95 NSD3_HUMAN 95.556 0.871359 0.286708 NSD3 - Histone-lysine N-methyltransferase NSD3 - Homo sapiens (Human) - NSD3 gene Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Indicus|evm.model.CM009517.1.204 O95429 BAG4_HUMAN 85.240 0.992647 0.595186 BAG4 - BAG family molecular chaperone regulator 4 - Homo sapiens (Human) - BAG4 gene Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. Indicus|evm.model.CM009517.1.205 O94830 DDHD2_HUMAN 92.453 0.961918 0.997187 DDHD2 - Phospholipase DDHD2 - Homo sapiens (Human) - DDHD2 gene Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. Indicus|evm.model.CM009517.1.206 Q9BZ95 NSD3_HUMAN 93.532 0.982828 0.688935 NSD3 - Histone-lysine N-methyltransferase NSD3 - Homo sapiens (Human) - NSD3 gene Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Indicus|evm.model.CM009517.1.207 Q2VYF4 LETM2_HUMAN 88.288 0.907104 0.745418 LETM2 - LETM1 domain-containing protein LETM2, mitochondrial precursor - Homo sapiens (Human) - LETM2 gene cellular metal ion homeostasis Indicus|evm.model.CM009517.1.208 P11362 FGFR1_HUMAN 98.418 0.997558 0.99635 FGFR1 - Fibroblast growth factor receptor 1 precursor - Homo sapiens (Human) - FGFR1 gene Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. Indicus|evm.model.CM009517.1.212 O75410 TACC1_HUMAN 87.857 0.635812 0.818634 TACC1 - Transforming acidic coiled-coil-containing protein 1 - Homo sapiens (Human) - TACC1 gene Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. Indicus|evm.model.CM009517.1.213 Q3ZBA3 PKHA2_BOVIN 100.000 0.640678 1.38824 PLEKHA2 - Pleckstrin homology domain-containing family A member 2 - Bos taurus (Bovine) - PLEKHA2 gene Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). Indicus|evm.model.CM009517.1.214 E1BJW1 HTRA4_BOVIN 95.015 0.97971 0.71281 HTRA4 - Serine protease HTR4 precursor - Bos taurus (Bovine) - HTRA4 gene Serine protease. Indicus|evm.model.CM009517.1.215 Q2TA35 TM2D2_BOVIN 100.000 0.990698 1.00467 TM2D2 - TM2 domain-containing protein 2 precursor - Bos taurus (Bovine) - TM2D2 gene Indicus|evm.model.CM009517.1.216 Q13443 ADAM9_HUMAN 85.871 0.997567 1.00366 ADAM9 - Disintegrin and metalloproteinase domain-containing protein 9 precursor - Homo sapiens (Human) - ADAM9 gene Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. Indicus|evm.model.CM009517.1.217 Q8TC27 ADA32_HUMAN 59.662 0.829358 0.692503 ADAM32 - Disintegrin and metalloproteinase domain-containing protein 32 precursor - Homo sapiens (Human) - ADAM32 gene May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. Indicus|evm.model.CM009517.1.218 Q28483 ADAM5_MACFA 60.519 0.962716 0.993386 ADAM5 - Disintegrin and metalloproteinase domain-containing protein 5 precursor - Macaca fascicularis (Crab-eating macaque) - ADAM5 gene This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity). Indicus|evm.model.CM009517.1.219 Q5R9C3 GPBL1_PONAB 84.000 0.837079 0.375527 GPBP1L1 - Vasculin-like protein 1 - Pongo abelii (Sumatran orangutan) - GPBP1L1 gene Possible transcription factor. Indicus|evm.model.CM009517.1.220 O77780 ADAM2_BOVIN 86.326 0.891102 1.01074 ADAM2 - Disintegrin and metalloproteinase domain-containing protein 2 precursor - Bos taurus (Bovine) - ADAM2 gene Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). Indicus|evm.model.CM009517.1.221 F8VQ03 ADAM3_MOUSE 51.560 0.974044 0.890511 Adam3 - A disintegrin and metallopeptidase domain 3 precursor - Mus musculus (Mouse) - Adam3 gene Involved in fertilization by controlling sperm migration into oviduct. Indicus|evm.model.CM009517.1.222 Q9Y3Q7 ADA18_HUMAN 65.984 0.96259 0.94046 ADAM18 - Disintegrin and metalloproteinase domain-containing protein 18 precursor - Homo sapiens (Human) - ADAM18 gene Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity). Indicus|evm.model.CM009517.1.223 P14902 I23O1_HUMAN 68.642 0.982801 1.00993 IDO1 - Indoleamine 2,3-dioxygenase 1 - Homo sapiens (Human) - IDO1 gene Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). Indicus|evm.model.CM009517.1.224 Q6ZQW0 I23O2_HUMAN 76.658 0.995098 0.971429 IDO2 - Indoleamine 2,3-dioxygenase 2 - Homo sapiens (Human) - IDO2 gene Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885). Indicus|evm.model.CM009517.1.225 Q5E969 TCIM_BOVIN 100.000 0.981308 1.00943 TCIM - Transcriptional and immune response regulator - Bos taurus (Bovine) - TCIM gene Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (By similarity). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (By similarity). Indicus|evm.model.CM009517.1.226 Q6ZWJ1 STXB4_HUMAN 70.064 0.590909 0.477396 STXBP4 - Syntaxin-binding protein 4 - Homo sapiens (Human) - STXBP4 gene Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). Indicus|evm.model.CM009517.1.227 P20821 GCSH_BOVIN 93.478 0.98913 0.531792 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Indicus|evm.model.CM009517.1.229 Q0VD35 ZMAT4_BOVIN 100.000 0.991304 1.00437 ZMAT4 - Zinc finger matrin-type protein 4 - Bos taurus (Bovine) - ZMAT4 gene Indicus|evm.model.CM009517.1.231 P62317 SMD2_MOUSE 55.085 0.943396 0.898305 Snrpd2 - Small nuclear ribonucleoprotein Sm D2 - Mus musculus (Mouse) - Snrpd2 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. Indicus|evm.model.CM009517.1.233 O19116 SFRP1_BOVIN 98.582 0.949324 0.961039 SFRP1 - Secreted frizzled-related protein 1 precursor - Bos taurus (Bovine) - SFRP1 gene Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. Indicus|evm.model.CM009517.1.234 Q7Z5G4 GOGA7_HUMAN 100.000 0.871795 1.13869 GOLGA7 - Golgin subfamily A member 7 - Homo sapiens (Human) - GOLGA7 gene May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. Indicus|evm.model.CM009517.1.235 A2VE40 SLD5_BOVIN 99.103 0.672727 1.47982 GINS4 - DNA replication complex GINS protein SLD5 - Bos taurus (Bovine) - GINS4 gene The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA. Indicus|evm.model.CM009517.1.237 A3FPG8 GPAT4_BOVIN 99.781 0.863378 1.1557 GPAT4 - Glycerol-3-phosphate acyltransferase 4 precursor - Bos taurus (Bovine) - GPAT4 gene Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (By similarity). Active against both saturated and unsaturated long-chain fatty acyl-CoAs (By similarity). Indicus|evm.model.CM009517.1.238 Q3UHX8 NKX63_MOUSE 90.152 0.992424 1.00763 Nkx6-3 - Homeobox protein Nkx-6.3 - Mus musculus (Mouse) - Nkx6-3 gene Putative transcription factor, which may be involved in patterning of central nervous system and pancreas. Indicus|evm.model.CM009517.1.239 P16157 ANK1_HUMAN 89.609 0.970526 1.0101 ANK1 - Ankyrin-1 - Homo sapiens (Human) - ANK1 gene Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Indicus|evm.model.CM009517.1.241 Q92794 KAT6A_HUMAN 97.690 0.149431 1.00848 KAT6A - Histone acetyltransferase KAT6A - Homo sapiens (Human) - KAT6A gene Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. Indicus|evm.model.CM009517.1.243 P53677 AP3M2_HUMAN 99.761 0.995227 1.00239 AP3M2 - AP-3 complex subunit mu-2 - Homo sapiens (Human) - AP3M2 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Indicus|evm.model.CM009517.1.244 Q28198 TPA_BOVIN 99.647 0.854766 1.16784 PLAT - Tissue-type plasminogen activator precursor - Bos taurus (Bovine) - PLAT gene Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy. Indicus|evm.model.CM009517.1.245 Q95KV0 IKKB_BOVIN 100.000 0.997358 1.00132 IKBKB - Inhibitor of nuclear factor kappa-B kinase subunit beta - Bos taurus (Bovine) - IKBKB gene Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (By similarity). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (By similarity). Indicus|evm.model.CM009517.1.246 Q27958 DPOLB_BOVIN 100.000 0.994048 1.00299 POLB - DNA polymerase beta - Bos taurus (Bovine) - POLB gene Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (By similarity). Indicus|evm.model.CM009517.1.247 Q9UBT3 DKK4_HUMAN 60.448 0.519531 1.14286 DKK4 - Dickkopf-related protein 4 precursor - Homo sapiens (Human) - DKK4 gene Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). Indicus|evm.model.CM009517.1.248 Q9MZ13 VDAC3_BOVIN 100.000 0.992958 1.00353 VDAC3 - Voltage-dependent anion-selective channel protein 3 - Bos taurus (Bovine) - VDAC3 gene Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. Indicus|evm.model.CM009517.1.250 A1A4I1 S20A2_BOVIN 99.845 0.996904 1.00155 SLC20A2 - Sodium-dependent phosphate transporter 2 - Bos taurus (Bovine) - SLC20A2 gene Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not significantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage calcification and vascular calcification. Functions as a retroviral receptor (By similarity). Indicus|evm.model.CM009517.1.252 A5D7B5 SMI19_BOVIN 100.000 0.981481 1.00935 SMIM19 - Small integral membrane protein 19 - Bos taurus (Bovine) - SMIM19 gene Indicus|evm.model.CM009517.1.253 Q5IS75 ACHB3_PANTR 90.393 0.995643 1.00218 CHRNB3 - Neuronal acetylcholine receptor subunit beta-3 precursor - Pan troglodytes (Chimpanzee) - CHRNB3 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Indicus|evm.model.CM009517.1.254 Q15825 ACHA6_HUMAN 87.247 0.99596 1.00202 CHRNA6 - Neuronal acetylcholine receptor subunit alpha-6 precursor - Homo sapiens (Human) - CHRNA6 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Indicus|evm.model.CM009517.1.255 Q3T0G1 THAP1_BOVIN 100.000 0.990654 1.00469 THAP1 - THAP domain-containing protein 1 - Bos taurus (Bovine) - THAP1 gene DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity). Indicus|evm.model.CM009517.1.256 F1MK05 RN170_BOVIN 99.614 0.992278 1 RNF170 - E3 ubiquitin-protein ligase RNF170 - Bos taurus (Bovine) - RNF170 gene E3 ubiquitin-protein ligase. Plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Indicus|evm.model.CM009517.1.257 Q86VS8 HOOK3_HUMAN 98.525 0.997054 0.945682 HOOK3 - Protein Hook homolog 3 - Homo sapiens (Human) - HOOK3 gene Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Indicus|evm.model.CM009517.1.258 P29702 FNTA_BOVIN 100.000 0.962457 0.781333 FNTA - Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha - Bos taurus (Bovine) - FNTA gene Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation (By similarity). Indicus|evm.model.CM009517.1.259 Q68CP4 HGNAT_HUMAN 82.638 0.640777 1.39819 HGSNAT - Heparan-alpha-glucosaminide N-acetyltransferase - Homo sapiens (Human) - HGSNAT gene Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. Indicus|evm.model.CM009517.1.261 Q9NVR2 INT10_HUMAN 96.761 0.997187 1.00141 INTS10 - Integrator complex subunit 10 - Homo sapiens (Human) - INTS10 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). Indicus|evm.model.CM009517.1.264 Q8TDX6 CGAT1_HUMAN 85.549 0.975238 0.986842 CSGALNACT1 - Chondroitin sulfate N-acetylgalactosaminyltransferase 1 - Homo sapiens (Human) - CSGALNACT1 gene Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758, PubMed:31705726). Moreover, is involved in the metabolism of aggrecan (By similarity). Indicus|evm.model.CM009517.1.265 Q6AYC8 SH24A_RAT 71.158 0.995283 1.00474 Sh2d4a - SH2 domain-containing protein 4A - Rattus norvegicus (Rat) - Sh2d4a gene Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function (By similarity). Indicus|evm.model.CM009517.1.266 P57016 LAD1_MOUSE 55.285 0.761006 0.301136 Lad1 - Ladinin-1 - Mus musculus (Mouse) - Lad1 gene Anchoring filament protein which is a component of the basement membrane zone. Indicus|evm.model.CM009517.1.267 Q9NYI0 PSD3_HUMAN 80.080 0.986869 0.944656 PSD3 - PH and SEC7 domain-containing protein 3 - Homo sapiens (Human) - PSD3 gene Guanine nucleotide exchange factor for ARF6. Indicus|evm.model.CM009517.1.268 Q1JPA6 ARY1_BOVIN 100.000 0.993127 1.00345 NAT1 - Arylamine N-acetyltransferase 1 - Bos taurus (Bovine) - NAT1 gene Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Indicus|evm.model.CM009517.1.269 A6H789 LRC3B_BOVIN 100.000 0.992308 1.00386 LRRC3B - Leucine-rich repeat-containing protein 3B precursor - Bos taurus (Bovine) - LRRC3B gene extracellular matrix, extracellular space Indicus|evm.model.CM009517.1.270 Q0VCA7 OXSM_BOVIN 99.348 0.995662 1.00217 OXSM - 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor - Bos taurus (Bovine) - OXSM gene May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Indicus|evm.model.CM009517.1.271 Q96IV0 NGLY1_HUMAN 84.492 0.700876 1.22171 NGLY1 - Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase - Homo sapiens (Human) - NGLY1 gene Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. Indicus|evm.model.CM009517.1.273 Q02880 TOP2B_HUMAN 96.010 0.998741 0.97663 TOP2B - DNA topoisomerase 2-beta - Homo sapiens (Human) - TOP2B gene Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Indicus|evm.model.CM009517.1.275 P22605 RARB_MOUSE 71.906 0.829861 0.59751 Rarb - Retinoic acid receptor beta - Mus musculus (Mouse) - Rarb gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355). Indicus|evm.model.CM009517.1.276 P18515 RARB_NOTVI 98.182 0.352941 0.968354 RARB - Retinoic acid receptor beta - Notophthalmus viridescens (Eastern newt) - RARB gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Indicus|evm.model.CM009517.1.280 P22605 RARB_MOUSE 83.607 0.582524 0.213693 Rarb - Retinoic acid receptor beta - Mus musculus (Mouse) - Rarb gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355). Indicus|evm.model.CM009517.1.283 P33991 MCM4_HUMAN 85.759 0.696386 0.480881 MCM4 - DNA replication licensing factor MCM4 - Homo sapiens (Human) - MCM4 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Indicus|evm.model.CM009517.1.284 Q5RCP8 H2B2E_PONAB 95.238 0.984252 1.00794 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009517.1.285 Q28571 THB_SHEEP 99.024 0.88913 1.11922 THRB - Thyroid hormone receptor beta - Ovis aries (Sheep) - THRB gene Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Indicus|evm.model.CM009517.1.286 Q14995 NR1D2_HUMAN 88.502 0.976109 1.01209 NR1D2 - Nuclear receptor subfamily 1 group D member 2 - Homo sapiens (Human) - NR1D2 gene Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle (By similarity). Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (By similarity). Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (By similarity). May play a role in the circadian control of neutrophilic inflammation in the lung (By similarity). Indicus|evm.model.CM009517.1.287 P61314 RL15_RAT 100.000 0.990244 1.0049 Rpl15 - 60S ribosomal protein L15 - Rattus norvegicus (Rat) - Rpl15 gene A band, cytosolic large ribosomal subunit, nucleus, RNA binding, structural constituent of ribosome, cytoplasmic translation, response to ethanol Indicus|evm.model.CM009517.1.288 Q9BH04 KBRS1_MACFA 97.917 0.989637 1.00521 NKIRAS1 - NF-kappa-B inhibitor-interacting Ras-like protein 1 - Macaca fascicularis (Crab-eating macaque) - NKIRAS1 gene Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). Indicus|evm.model.CM009517.1.289 P51965 UB2E1_HUMAN 100.000 0.987261 0.813472 UBE2E1 - Ubiquitin-conjugating enzyme E2 E1 - Homo sapiens (Human) - UBE2E1 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Indicus|evm.model.CM009517.1.290 Q96LR5 UB2E2_HUMAN 100.000 0.984127 0.626866 UBE2E2 - Ubiquitin-conjugating enzyme E2 E2 - Homo sapiens (Human) - UBE2E2 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. Indicus|evm.model.CM009517.1.292 A2Q0Z0 EF1A1_HORSE 55.061 0.930894 0.532468 EEF1A1 - Elongation factor 1-alpha 1 - Equus caballus (Horse) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009517.1.298 Q9H6B1 Z385D_HUMAN 95.076 0.929078 0.713924 ZNF385D - Zinc finger protein 385D - Homo sapiens (Human) - ZNF385D gene nucleus, sequence-specific double-stranded DNA binding Indicus|evm.model.CM009517.1.301 Q9UFH2 DYH17_HUMAN 84.375 0.424658 0.0163604 DNAH17 - Dynein axonemal heavy chain 17 - Homo sapiens (Human) - DNAH17 gene Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (Probable). Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating (PubMed:31178125). Indicus|evm.model.CM009518.1.2 Q2TBH7 RAB4A_BOVIN 100.000 0.990868 1.00459 RAB4A - Ras-related protein Rab-4A - Bos taurus (Bovine) - RAB4A gene Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). Indicus|evm.model.CM009518.1.3 Q6IQ19 CCSAP_HUMAN 69.343 0.920415 1.07037 CCSAP - Centriole, cilia and spindle-associated protein - Homo sapiens (Human) - CCSAP gene Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity). Indicus|evm.model.CM009518.1.4 P68136 ACTS_RAT 100.000 0.994709 1.00265 Acta1 - Actin, alpha skeletal muscle precursor - Rattus norvegicus (Rat) - Acta1 gene Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Indicus|evm.model.CM009518.1.5 Q8WUM0 NU133_HUMAN 90.138 0.998271 1.00087 NUP133 - Nuclear pore complex protein Nup133 - Homo sapiens (Human) - NUP133 gene Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). Indicus|evm.model.CM009518.1.6 Q9NRK6 ABCBA_HUMAN 90.958 0.99639 0.750678 ABCB10 - ATP-binding cassette sub-family B member 10, mitochondrial precursor - Homo sapiens (Human) - ABCB10 gene Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner (PubMed:33253225). May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria (PubMed:33253225). Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress (PubMed:28808058, PubMed:22085049). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685). Indicus|evm.model.CM009518.1.7 O75529 TAF5L_HUMAN 93.718 0.99661 1.0017 TAF5L - TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L - Homo sapiens (Human) - TAF5L gene Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity). Indicus|evm.model.CM009518.1.8 Q14146 URB2_HUMAN 73.539 0.9819 1.01509 URB2 - Unhealthy ribosome biogenesis protein 2 homolog - Homo sapiens (Human) - URB2 gene aggresome, midbody, nucleolus, ribosome biogenesis Indicus|evm.model.CM009518.1.9 Q8AVY0 TOM20_XENLA 81.818 0.614286 0.47619 tomm20 - Mitochondrial import receptor subunit TOM20 homolog - Xenopus laevis (African clawed frog) - tomm20 gene Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the tom40 translocation pore (By similarity). Indicus|evm.model.CM009518.1.10 Q6PB93 GALT2_MOUSE 96.395 0.951175 0.970175 Galnt2 - Polypeptide N-acetylgalactosaminyltransferase 2 - Mus musculus (Mouse) - Galnt2 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region (By similarity). Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates to the regulation of HDL-C metabolism (PubMed:27508872). Indicus|evm.model.CM009518.1.11 D3YZI9 PGBD5_MOUSE 94.608 0.992683 0.783939 Pgbd5 - PiggyBac transposable element-derived protein 5 - Mus musculus (Mouse) - Pgbd5 gene Transposase that mediates sequence-specific genomic rearrangements. Indicus|evm.model.CM009518.1.12 Q9NZ56 FMN2_HUMAN 89.071 0.928571 0.113821 FMN2 - Formin-2 - Homo sapiens (Human) - FMN2 gene Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:22330775, PubMed:21730168). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:22330775, PubMed:21730168). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). Indicus|evm.model.CM009518.1.14 A5D7J5 RHOU_BOVIN 98.618 0.824427 1.02745 RHOU - Rho-related GTP-binding protein RhoU - Bos taurus (Bovine) - RHOU gene Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). Indicus|evm.model.CM009518.1.15 Q8NGL2 OR5L1_HUMAN 79.310 0.95 0.192926 OR5L1 - Olfactory receptor 5L1 - Homo sapiens (Human) - OR5L1 gene Odorant receptor. Indicus|evm.model.CM009518.1.17 Q8NGL7 OR4P4_HUMAN 53.676 0.934783 0.442308 OR4P4 - Olfactory receptor 4P4 - Homo sapiens (Human) - OR4P4 gene Odorant receptor. Indicus|evm.model.CM009518.1.18 Q9NRI5 DISC1_HUMAN 46.769 0.638831 0.56089 DISC1 - Disrupted in schizophrenia 1 protein - Homo sapiens (Human) - DISC1 gene Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19502360, PubMed:19303846). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030). Indicus|evm.model.CM009518.1.19 Q5RC21 TSNAX_PONAB 97.241 0.993127 1.00345 TSNAX - Translin-associated protein X - Pongo abelii (Sumatran orangutan) - TSNAX gene Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity). Indicus|evm.model.CM009518.1.20 P09244 TBB7_CHICK 95.338 0.961798 1.00225 Tubulin beta-7 chain - Gallus gallus (Chicken) Indicus|evm.model.CM009518.1.21 Q3T013 BNI3L_BOVIN 99.543 0.990909 1.00457 BNIP3L - BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like - Bos taurus (Bovine) - BNIP3L gene Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity). Indicus|evm.model.CM009518.1.22 Q9GZT9 EGLN1_HUMAN 74.434 0.989865 0.694836 EGLN1 - Egl nine homolog 1 - Homo sapiens (Human) - EGLN1 gene Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif. Indicus|evm.model.CM009518.1.23 Q9GZT9 EGLN1_HUMAN 97.674 0.948148 0.316901 EGLN1 - Egl nine homolog 1 - Homo sapiens (Human) - EGLN1 gene Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif. Indicus|evm.model.CM009518.1.24 A5D979 SPRTN_BOVIN 99.179 0.954635 1.04107 SPRTN - DNA-dependent metalloprotease SPRTN - Bos taurus (Bovine) - SPRTN gene DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis. Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (By similarity). Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity). Involved in recruitment of VCP/p97 to sites of DNA damage. Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation. Does not activate CHEK1 in response to DNA damage. May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (By similarity). Indicus|evm.model.CM009518.1.25 A4IF89 EXOC8_BOVIN 100.000 0.997245 1.00138 EXOC8 - Exocyst complex component 8 - Bos taurus (Bovine) - EXOC8 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Indicus|evm.model.CM009518.1.26 A4IF87 GNPAT_BOVIN 99.831 0.954839 0.911765 GNPAT - Dihydroxyacetone phosphate acyltransferase - Bos taurus (Bovine) - GNPAT gene Dihydroxyacetonephosphate acyltransferase involved in plasmalogen biosynthesis. Indicus|evm.model.CM009518.1.27 Q8NDD1 CA131_HUMAN 71.034 0.993103 0.989761 C1orf131 - Uncharacterized protein C1orf131 - Homo sapiens (Human) - C1orf131 gene chromosome, RNA binding Indicus|evm.model.CM009518.1.28 Q6ZTA4 TRI67_HUMAN 98.072 0.518625 0.891443 TRIM67 - Tripartite motif-containing protein 67 - Homo sapiens (Human) - TRIM67 gene regulation of cellular protein localization Indicus|evm.model.CM009518.1.29 A6QQF7 FA89A_BOVIN 100.000 0.988827 1.00562 FAM89A - Protein FAM89A - Bos taurus (Bovine) - FAM89A gene Indicus|evm.model.CM009518.1.30 Q3SZW3 ARV1_BOVIN 98.227 0.992933 1.00355 ARV1 - Protein ARV1 - Bos taurus (Bovine) - ARV1 gene Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes. Indicus|evm.model.CM009518.1.31 Q8NBP0 TTC13_HUMAN 98.605 0.997672 0.998837 TTC13 - Tetratricopeptide repeat protein 13 - Homo sapiens (Human) - TTC13 gene Indicus|evm.model.CM009518.1.32 Q58CU6 CA198_BOVIN 100.000 0.908676 0.673846 Uncharacterized protein C1orf198 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009518.1.35 Q9NZ56 FMN2_HUMAN 95.218 0.387097 0.720093 FMN2 - Formin-2 - Homo sapiens (Human) - FMN2 gene Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:22330775, PubMed:21730168). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:22330775, PubMed:21730168). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). Indicus|evm.model.CM009518.1.36 Q2KIZ3 MCEE_BOVIN 86.000 0.96 0.285714 MCEE - Methylmalonyl-CoA epimerase, mitochondrial precursor - Bos taurus (Bovine) - MCEE gene Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism. Indicus|evm.model.CM009518.1.38 Q9NRI5 DISC1_HUMAN 74.556 0.964706 0.199063 DISC1 - Disrupted in schizophrenia 1 protein - Homo sapiens (Human) - DISC1 gene Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19502360, PubMed:19303846). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030). Indicus|evm.model.CM009518.1.40 Q9P2F8 SI1L2_HUMAN 93.202 0.998256 0.998839 SIPA1L2 - Signal-induced proliferation-associated 1-like protein 2 - Homo sapiens (Human) - SIPA1L2 gene cytoplasm, GTPase activator activity, activation of GTPase activity Indicus|evm.model.CM009518.1.41 A3KMW7 MAP10_BOVIN 98.248 0.997812 1.00219 MAP10 - Microtubule-associated protein 10 - Bos taurus (Bovine) - MAP10 gene Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis. Indicus|evm.model.CM009518.1.42 Q1LZ78 NTPCR_BOVIN 99.474 0.989529 1.00526 NTPCR - Cancer-related nucleoside-triphosphatase homolog - Bos taurus (Bovine) - NTPCR gene Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency (By similarity). Indicus|evm.model.CM009518.1.43 A6NKB5 PCX2_HUMAN 82.320 0.999057 0.992045 PCNX2 - Pecanex-like protein 2 - Homo sapiens (Human) - PCNX2 gene May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Indicus|evm.model.CM009518.1.44 Q5TCX8 M3K21_HUMAN 80.344 0.998092 1.01158 MAP3K21 - Mitogen-activated protein kinase kinase kinase 21 - Homo sapiens (Human) - MAP3K21 gene Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. Indicus|evm.model.CM009518.1.45 Q0P5A0 KCNK1_BOVIN 100.000 0.994065 1.00298 KCNK1 - Potassium channel subfamily K member 1 - Bos taurus (Bovine) - KCNK1 gene Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (By similarity). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (By similarity). Indicus|evm.model.CM009518.1.49 Q8IY50 S35F3_HUMAN 95.249 0.995261 1.00238 SLC35F3 - Putative thiamine transporter SLC35F3 - Homo sapiens (Human) - SLC35F3 gene May be a thiamine transporter. Indicus|evm.model.CM009518.1.50 Q2M2S5 COA6_BOVIN 100.000 0.886792 0.670886 COA6 - Cytochrome c oxidase assembly factor 6 homolog - Bos taurus (Bovine) - COA6 gene Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. Indicus|evm.model.CM009518.1.51 Q13395 TARB1_HUMAN 85.814 0.995294 0.786552 TARBP1 - Probable methyltransferase TARBP1 - Homo sapiens (Human) - TARBP1 gene Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. Indicus|evm.model.CM009518.1.52 Q7Z5L9 I2BP2_HUMAN 95.732 0.934286 0.596252 IRF2BP2 - Interferon regulatory factor 2-binding protein 2 - Homo sapiens (Human) - IRF2BP2 gene Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). Indicus|evm.model.CM009518.1.55 Q5RA31 TOM20_PONAB 100.000 0.986301 1.0069 TOMM20 - Mitochondrial import receptor subunit TOM20 homolog - Pongo abelii (Sumatran orangutan) - TOMM20 gene Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. Indicus|evm.model.CM009518.1.56 P42696 RBM34_HUMAN 81.163 0.995338 0.997674 RBM34 - RNA-binding protein 34 - Homo sapiens (Human) - RBM34 gene chromosome, nucleolus, nucleoplasm, RNA binding Indicus|evm.model.CM009518.1.57 Q4LE39 ARI4B_HUMAN 91.400 0.998477 1.00076 ARID4B - AT-rich interactive domain-containing protein 4B - Homo sapiens (Human) - ARID4B gene Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). Indicus|evm.model.CM009518.1.58 P56966 GGPPS_BOVIN 100.000 0.993355 1.00333 GGPS1 - Geranylgeranyl pyrophosphate synthase - Bos taurus (Bovine) - GGPS1 gene Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Indicus|evm.model.CM009518.1.59 Q32KS0 TBCE_BOVIN 99.242 0.807044 1.23674 TBCE - Tubulin-specific chaperone E - Bos taurus (Bovine) - TBCE gene Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. Indicus|evm.model.CM009518.1.60 Q8NCR0 B3GL2_HUMAN 93.200 0.994024 1.004 B3GALNT2 - UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 - Homo sapiens (Human) - B3GALNT2 gene Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Indicus|evm.model.CM009518.1.62 Q5R639 GBG4_PONAB 98.667 0.333333 2.96 GNG4 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor - Pongo abelii (Sumatran orangutan) - GNG4 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009518.1.63 Q9TTK4 LYST_BOVIN 99.921 0.999473 1.00026 LYST - Lysosomal-trafficking regulator - Bos taurus (Bovine) - LYST gene May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules. Indicus|evm.model.CM009518.1.64 P14543 NID1_HUMAN 88.551 0.977273 0.670409 NID1 - Nidogen-1 precursor - Homo sapiens (Human) - NID1 gene Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Indicus|evm.model.CM009518.1.65 P14543 NID1_HUMAN 83.523 0.988701 0.141941 NID1 - Nidogen-1 precursor - Homo sapiens (Human) - NID1 gene Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Indicus|evm.model.CM009518.1.66 O60478 G137B_HUMAN 91.192 0.994695 0.944862 GPR137B - Integral membrane protein GPR137B - Homo sapiens (Human) - GPR137B gene Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939). Indicus|evm.model.CM009518.1.67 Q86YB8 ERO1B_HUMAN 96.788 0.960825 1.03854 ERO1B - ERO1-like protein beta precursor - Homo sapiens (Human) - ERO1B gene Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 ( Indicus|evm.model.CM009518.1.68 Q710C4 SAHH_PIG 77.551 0.941748 0.238426 AHCY - Adenosylhomocysteinase - Sus scrofa (Pig) - AHCY gene Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Indicus|evm.model.CM009518.1.71 Q95LN5 EDAD_MACFA 71.282 0.930636 0.839806 EDARADD - Ectodysplasin-A receptor-associated adapter protein - Macaca fascicularis (Crab-eating macaque) - EDARADD gene Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B (By similarity). Indicus|evm.model.CM009518.1.72 O00214 LEG8_HUMAN 75.070 0.994413 1.12934 LGALS8 - Galectin-8 - Homo sapiens (Human) - LGALS8 gene Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902). Indicus|evm.model.CM009518.1.73 Q9GM44 HEAT1_MACFA 89.562 0.445637 2.23695 HEATR1 - HEAT repeat-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - HEATR1 gene Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Indicus|evm.model.CM009518.1.74 Q3ZC55 ACTN2_BOVIN 99.883 0.989559 0.964206 ACTN2 - Alpha-actinin-2 - Bos taurus (Bovine) - ACTN2 gene F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). Indicus|evm.model.CM009518.1.75 Q4JIJ3 METH_BOVIN 99.684 0.99842 1.00079 MTR - Methionine synthase - Bos taurus (Bovine) - MTR gene Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Indicus|evm.model.CM009518.1.78 Q92736 RYR2_HUMAN 97.980 0.999595 0.994564 RYR2 - Ryanodine receptor 2 - Homo sapiens (Human) - RYR2 gene Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. Indicus|evm.model.CM009518.1.79 Q9BH11 ZP4_BOVIN 99.771 0.95186 0.855805 ZP4 - Zona pellucida sperm-binding protein 4 precursor - Bos taurus (Bovine) - ZP4 gene Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. Indicus|evm.model.CM009518.1.80 Q13398 ZN211_HUMAN 50.000 0.866667 0.132979 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009518.1.81 P62958 HINT1_BOVIN 92.754 0.971429 0.555556 HINT1 - Histidine triad nucleotide-binding protein 1 - Bos taurus (Bovine) - HINT1 gene Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Indicus|evm.model.CM009518.1.83 P41984 ACM3_BOVIN 100.000 0.9866 1.01186 CHRM3 - Muscarinic acetylcholine receptor M3 - Bos taurus (Bovine) - CHRM3 gene The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Indicus|evm.model.CM009518.1.84 Q12967 GNDS_HUMAN 58.974 0.802083 0.105033 RALGDS - Ral guanine nucleotide dissociation stimulator - Homo sapiens (Human) - RALGDS gene Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Indicus|evm.model.CM009518.1.85 Q06732 ZN33B_HUMAN 85.494 0.996159 1.00386 ZNF33B - Zinc finger protein 33B - Homo sapiens (Human) - ZNF33B gene May be involved in transcriptional regulation. Indicus|evm.model.CM009518.1.86 P17032 ZN37A_HUMAN 69.348 0.798464 0.928699 ZNF37A - Zinc finger protein 37A - Homo sapiens (Human) - ZNF37A gene May be involved in transcriptional regulation. Indicus|evm.model.CM009518.1.87 Q03385 GNDS_MOUSE 59.375 0.358537 0.481221 Ralgds - Ral guanine nucleotide dissociation stimulator - Mus musculus (Mouse) - Ralgds gene Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Indicus|evm.model.CM009518.1.88 P17030 ZNF25_HUMAN 83.444 0.993363 0.991228 ZNF25 - Zinc finger protein 25 - Homo sapiens (Human) - ZNF25 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009518.1.89 Q8NDW4 ZN248_HUMAN 82.902 0.996546 1 ZNF248 - Zinc finger protein 248 - Homo sapiens (Human) - ZNF248 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009518.1.90 Q5VTM2 AGAP9_HUMAN 96.629 0.0683761 1.83073 AGAP9 - Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9 - Homo sapiens (Human) - AGAP9 gene Putative GTPase-activating protein. Indicus|evm.model.CM009518.1.91 Q8K3Y3 LN28A_MOUSE 66.423 0.777778 0.645933 Lin28a - Protein lin-28 homolog A - Mus musculus (Mouse) - Lin28a gene RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:17473174, PubMed:18604195, PubMed:18566191, PubMed:18292307, PubMed:19703396, PubMed:23102813, PubMed:24209617). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (PubMed:26045559). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (PubMed:17473174). Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferaseS. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:19703396, PubMed:28671666). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins (PubMed:23102813). Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (PubMed:24209617). Indicus|evm.model.CM009518.1.92 P07949 RET_HUMAN 87.165 0.994275 0.940754 RET - Proto-oncogene tyrosine-protein kinase receptor Ret precursor - Homo sapiens (Human) - RET gene Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways (PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL (PubMed:28846099). Indicus|evm.model.CM009518.1.93 Q8N6G5 CGAT2_HUMAN 96.303 0.818182 1.21771 CSGALNACT2 - Chondroitin sulfate N-acetylgalactosaminyltransferase 2 - Homo sapiens (Human) - CSGALNACT2 gene Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Indicus|evm.model.CM009518.1.94 Q8N9B8 RGF1A_HUMAN 95.426 0.995842 1 RASGEF1A - Ras-GEF domain-containing family member 1A - Homo sapiens (Human) - RASGEF1A gene Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration. Indicus|evm.model.CM009518.1.95 Q63113 FXYD4_RAT 71.642 0.425806 1.78161 Fxyd4 - FXYD domain-containing ion transport regulator 4 precursor - Rattus norvegicus (Rat) - Fxyd4 gene Induces a potassium channel when expressed in Xenopus oocytes. Indicus|evm.model.CM009518.1.96 Q5E9J1 HNRPF_BOVIN 100.000 0.995181 1.00242 HNRNPF - Heterogeneous nuclear ribonucleoprotein F - Bos taurus (Bovine) - HNRNPF gene Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity). Indicus|evm.model.CM009518.1.97 Q9H694 BICC1_HUMAN 96.491 0.890304 1.04825 BICC1 - Protein bicaudal C homolog 1 - Homo sapiens (Human) - BICC1 gene Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. Indicus|evm.model.CM009518.1.98 Q32L96 PHIPL_BOVIN 100.000 0.64433 1.54787 PHYHIPL - Phytanoyl-CoA hydroxylase interacting protein-like - Bos taurus (Bovine) - PHYHIPL gene May play a role in the development of the central system. Indicus|evm.model.CM009518.1.99 Q8NE31 FA13C_HUMAN 87.179 0.996558 0.993162 FAM13C - Protein FAM13C - Homo sapiens (Human) - FAM13C gene Indicus|evm.model.CM009518.1.100 Q5R5M4 MOT9_PONAB 91.749 0.988327 1.00982 SLC16A9 - Monocarboxylate transporter 9 - Pongo abelii (Sumatran orangutan) - SLC16A9 gene Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Indicus|evm.model.CM009518.1.101 Q16204 CCDC6_HUMAN 98.928 0.900726 0.871308 CCDC6 - Coiled-coil domain-containing protein 6 - Homo sapiens (Human) - CCDC6 gene cytosol, identical protein binding, structural constituent of cytoskeleton Indicus|evm.model.CM009518.1.103 Q12955 ANK3_HUMAN 97.521 0.0301583 0.90907 ANK3 - Ankyrin-3 - Homo sapiens (Human) - ANK3 gene In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Indicus|evm.model.CM009518.1.105 P48734 CDK1_BOVIN 100.000 0.993289 1.00337 CDK1 - Cyclin-dependent kinase 1 - Bos taurus (Bovine) - CDK1 gene Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis. Regulates the amplitude of the cyclic expression of the core clock gene ARNTL/BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (By similarity). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (By similarity). Indicus|evm.model.CM009518.1.106 O46414 FRIH_BOVIN 82.963 0.683673 1.08287 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009518.1.107 O94844 RHBT1_HUMAN 93.696 0.997139 1.00431 RHOBTB1 - Rho-related BTB domain-containing protein 1 - Homo sapiens (Human) - RHOBTB1 gene cell cortex, cell projection, cytoplasmic vesicle, cytoskeleton, endosome membrane, intracellular membrane-bounded organelle, plasma membrane, GTP binding, GTPase activity, protein kinase binding Indicus|evm.model.CM009518.1.110 Q6ZUK4 TMM26_HUMAN 72.283 0.993569 0.845109 TMEM26 - Transmembrane protein 26 - Homo sapiens (Human) - TMEM26 gene Indicus|evm.model.CM009518.1.111 Q8IVU9 CBCO1_HUMAN 83.173 0.678808 1.45192 CABCOCO1 - Ciliary-associated calcium-binding coiled-coil protein 1 - Homo sapiens (Human) - CABCOCO1 gene Calcium-binding protein. May be involved in the control of sperm flagellar movement. Indicus|evm.model.CM009518.1.112 E1BLP6 ARI5B_BOVIN 95.179 0.956349 0.859335 ARID5B - AT-rich interactive domain-containing protein 5B - Bos taurus (Bovine) - ARID5B gene Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-340, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation (By similarity). Indicus|evm.model.CM009518.1.113 Q8IZC4 RTKN2_HUMAN 82.102 0.996661 0.98358 RTKN2 - Rhotekin-2 - Homo sapiens (Human) - RTKN2 gene May play an important role in lymphopoiesis. Indicus|evm.model.CM009518.1.115 Q5R9L2 ZN365_PONAB 88.206 0.995074 0.997543 ZNF365 - Protein ZNF365 - Pongo abelii (Sumatran orangutan) - ZNF365 gene Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (By similarity). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery. Contributes to genomic stability by preventing telomere dysfunction (By similarity). Indicus|evm.model.CM009518.1.116 Q96SZ5 AEDO_HUMAN 90.741 0.99262 1.0037 ADO - 2-aminoethanethiol dioxygenase - Homo sapiens (Human) - ADO gene cytosol, sulfur amino acid catabolic process Indicus|evm.model.CM009518.1.117 A1XSY8 EGR2_PIG 95.975 0.995772 1.00425 EGR2 - E3 SUMO-protein ligase EGR2 - Sus scrofa (Pig) - EGR2 gene Sequence-specific DNA-binding transcription factor (By similarity). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity). Indicus|evm.model.CM009518.1.118 Q5R4C9 NRBF2_PONAB 93.056 0.784153 1.27526 NRBF2 - Nuclear receptor-binding factor 2 - Pongo abelii (Sumatran orangutan) - NRBF2 gene May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity). Indicus|evm.model.CM009518.1.119 Q15652 JHD2C_HUMAN 91.627 0.999211 0.998425 JMJD1C - Probable JmjC domain-containing histone demethylation protein 2C - Homo sapiens (Human) - JMJD1C gene Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). Indicus|evm.model.CM009518.1.120 Q6NUK4 REEP3_HUMAN 95.417 0.991701 0.945098 REEP3 - Receptor expression-enhancing protein 3 - Homo sapiens (Human) - REEP3 gene Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. Indicus|evm.model.CM009518.1.121 Q920A7 AFG31_MOUSE 73.585 0.660377 0.201521 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Indicus|evm.model.CM009518.1.122 P17077 RL9_RAT 57.754 0.961538 0.677083 Rpl9 - 60S ribosomal protein L9 - Rattus norvegicus (Rat) - Rpl9 gene cytosolic large ribosomal subunit, synapse, structural constituent of ribosome, cellular response to nerve growth factor stimulus, cytoplasmic translation Indicus|evm.model.CM009518.1.123 P84092 AP2M1_RAT 98.693 0.968254 0.724138 Ap2m1 - AP-2 complex subunit mu - Rattus norvegicus (Rat) - Ap2m1 gene Component of the adaptor protein complex 2 (AP-2) (PubMed:14745134, PubMed:15473838). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:14745134, PubMed:15473838). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:14745134, PubMed:15473838). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:14745134, PubMed:15473838). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:14745134, PubMed:15473838). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed:14745134, PubMed:15473838). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed:14745134, PubMed:15473838). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (By similarity). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (PubMed:15985462). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (By similarity). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 mu (AP2M1) subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (PubMed:15985462). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed:15985462, PubMed:11516654). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling (PubMed:20947020). Indicus|evm.model.CM009518.1.124 Q9UI47 CTNA3_HUMAN 97.436 0.991489 0.26257 CTNNA3 - Catenin alpha-3 - Homo sapiens (Human) - CTNNA3 gene May be involved in formation of stretch-resistant cell-cell adhesion complexes. Indicus|evm.model.CM009518.1.125 Q9UI47 CTNA3_HUMAN 95.324 0.865625 0.357542 CTNNA3 - Catenin alpha-3 - Homo sapiens (Human) - CTNNA3 gene May be involved in formation of stretch-resistant cell-cell adhesion complexes. Indicus|evm.model.CM009518.1.126 Q9BGP6 LRRT3_MACFA 99.139 0.996564 1.00172 LRRTM3 - Leucine-rich repeat transmembrane neuronal protein 3 precursor - Macaca fascicularis (Crab-eating macaque) - LRRTM3 gene May play a role in the development and maintenance of the vertebrate nervous system. Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). Indicus|evm.model.CM009518.1.127 Q92734 TFG_HUMAN 93.333 0.967611 0.6175 TFG - Protein TFG - Homo sapiens (Human) - TFG gene Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). Indicus|evm.model.CM009518.1.128 Q9UI47 CTNA3_HUMAN 93.732 0.890585 0.439106 CTNNA3 - Catenin alpha-3 - Homo sapiens (Human) - CTNNA3 gene May be involved in formation of stretch-resistant cell-cell adhesion complexes. Indicus|evm.model.CM009518.1.130 Q9N287 DJC12_BOVIN 99.495 0.98995 1.00505 DNAJC12 - DnaJ homolog subfamily C member 12 - Bos taurus (Bovine) - DNAJC12 gene cytoplasm Indicus|evm.model.CM009518.1.131 Q96EB6 SIR1_HUMAN 90.586 0.958333 0.899598 SIRT1 - NAD-dependent protein deacetylase sirtuin-1 - Homo sapiens (Human) - SIRT1 gene NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:24415752, PubMed:24824780). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:15152190, PubMed:14980222, PubMed:14976264). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14980222, PubMed:14976264, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17620057, PubMed:17283066, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteosomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism (PubMed:20817729). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis. Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:17334224, PubMed:16998810, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including ARNTL/BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates ARNTL/BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteosome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). In addition to protein deacetylase activity, also acts as protein-lysine deacylase: acts as a protein depropionylase by mediating depropionylation of Osterix (SP7) (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication. Deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Indicus|evm.model.CM009518.1.132 Q5GLZ8 HERC4_HUMAN 97.540 0.99811 1.00095 HERC4 - Probable E3 ubiquitin-protein ligase HERC4 - Homo sapiens (Human) - HERC4 gene Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. Indicus|evm.model.CM009518.1.133 Q86TC9 MYPN_HUMAN 91.597 0.998486 1.00076 MYPN - Myopalladin - Homo sapiens (Human) - MYPN gene Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. Indicus|evm.model.CM009518.1.134 Q8N100 ATOH7_HUMAN 90.789 0.986928 1.00658 ATOH7 - Protein atonal homolog 7 - Homo sapiens (Human) - ATOH7 gene Transcription factor that positively regulates the determination of retinal ganglion cell fate and formation of the optic nerve and retino-hypothalamic tract (By similarity). Required for retinal circadian rhythm photoentrainment (By similarity). Indicus|evm.model.CM009518.1.135 Q2HJF4 PBLD_BOVIN 100.000 0.99308 1.00347 PBLD - Phenazine biosynthesis-like domain-containing protein - Bos taurus (Bovine) - PBLD gene cytoplasm, isomerase activity Indicus|evm.model.CM009518.1.136 P31942 HNRH3_HUMAN 100.000 0.819477 1.21676 HNRNPH3 - Heterogeneous nuclear ribonucleoprotein H3 - Homo sapiens (Human) - HNRNPH3 gene Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. Indicus|evm.model.CM009518.1.137 E1BMP7 DNA2_BOVIN 99.588 0.641722 1.42319 DNA2 - DNA replication ATP-dependent helicase/nuclease DNA2 - Bos taurus (Bovine) - DNA2 gene Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function (By similarity). Indicus|evm.model.CM009518.1.138 Q01888 GDC_BOVIN 99.697 0.993958 1.00303 SLC25A16 - Graves disease carrier protein - Bos taurus (Bovine) - SLC25A16 gene Required for the accumulation of coenzyme A in the mitochondrial matrix. Indicus|evm.model.CM009518.1.139 Q9HCP6 HHATL_HUMAN 52.381 0.75 0.380952 HHATL - Protein-cysteine N-palmitoyltransferase HHAT-like protein - Homo sapiens (Human) - HHATL gene Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN. Indicus|evm.model.CM009518.1.140 Q8NFU7 TET1_HUMAN 81.955 0.258537 0.959738 TET1 - Methylcytosine dioxygenase TET1 - Homo sapiens (Human) - TET1 gene Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). Indicus|evm.model.CM009518.1.141 Q8IX12 CCAR1_HUMAN 98.913 0.980769 0.406957 CCAR1 - Cell division cycle and apoptosis regulator protein 1 - Homo sapiens (Human) - CCAR1 gene Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). Indicus|evm.model.CM009518.1.142 Q8IX12 CCAR1_HUMAN 97.217 0.985321 0.473913 CCAR1 - Cell division cycle and apoptosis regulator protein 1 - Homo sapiens (Human) - CCAR1 gene Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). Indicus|evm.model.CM009518.1.143 Q6ZVD7 STOX1_HUMAN 74.747 0.99797 0.995956 STOX1 - Storkhead-box protein 1 - Homo sapiens (Human) - STOX1 gene Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). Indicus|evm.model.CM009518.1.144 Q9BQ39 DDX50_HUMAN 97.422 0.99729 1.00136 DDX50 - ATP-dependent RNA helicase DDX50 - Homo sapiens (Human) - DDX50 gene membrane, nucleolus, plasma membrane, RNA binding, RNA helicase activity Indicus|evm.model.CM009518.1.145 Q9NR30 DDX21_HUMAN 88.917 0.997452 1.00255 DDX21 - Nucleolar RNA helicase 2 - Homo sapiens (Human) - DDX21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Indicus|evm.model.CM009518.1.146 Q3SYS9 KBP_BOVIN 100.000 0.948012 1.05314 KIFBP - KIF-binding protein - Bos taurus (Bovine) - KIFBP gene Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. Indicus|evm.model.CM009518.1.147 P10124 SRGN_HUMAN 58.599 0.986755 0.955696 SRGN - Serglycin precursor - Homo sapiens (Human) - SRGN gene Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization. Indicus|evm.model.CM009518.1.148 Q0VD53 VP26A_BOVIN 100.000 0.993902 1.00306 VPS26A - Vacuolar protein sorting-associated protein 26A - Bos taurus (Bovine) - VPS26A gene Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC complex seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2 (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Acts redundantly with VSP26B in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). Indicus|evm.model.CM009518.1.149 Q8IYB8 SUV3_HUMAN 90.470 0.997462 1.00254 SUPV3L1 - ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor - Homo sapiens (Human) - SUPV3L1 gene Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. Indicus|evm.model.CM009518.1.150 Q2TB90 HKDC1_HUMAN 92.912 0.997821 1.00109 HKDC1 - Hexokinase HKDC1 - Homo sapiens (Human) - HKDC1 gene Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (PubMed:30517626). Has low glucose phosphorylating activity compared to other hexokinases (PubMed:30517626). Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity). Indicus|evm.model.CM009518.1.151 P19367 HXK1_HUMAN 95.095 0.9718 1.00545 HK1 - Hexokinase-1 - Homo sapiens (Human) - HK1 gene Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). Indicus|evm.model.CM009518.1.152 P05363 NK2R_BOVIN 98.205 0.994885 1.01823 TACR2 - Substance-K receptor - Bos taurus (Bovine) - TACR2 gene This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. Indicus|evm.model.CM009518.1.153 Q1JQA4 TSN15_BOVIN 100.000 0.99322 1.0034 TSPAN15 - Tetraspanin-15 - Bos taurus (Bovine) - TSPAN15 gene Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Promotes ADAM10-mediated cleavage of CDH2 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Indicus|evm.model.CM009518.1.154 Q9Y4Z2 NGN3_HUMAN 82.326 0.761566 1.31308 NEUROG3 - Neurogenin-3 - Homo sapiens (Human) - NEUROG3 gene Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). Indicus|evm.model.CM009518.1.155 Q96D05 F241B_HUMAN 94.215 0.983471 1 FAM241B - Protein FAM241B - Homo sapiens (Human) - FAM241B gene May play a role in lysosome homeostasis. Indicus|evm.model.CM009518.1.156 Q5TAT6 CODA1_HUMAN 87.755 0.598361 0.340307 COL13A1 - Collagen alpha-1(XIII) chain - Homo sapiens (Human) - COL13A1 gene Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625). Indicus|evm.model.CM009518.1.157 Q9R1N9 CODA1_MOUSE 80.602 0.99633 0.725699 Col13a1 - Collagen alpha-1(XIII) chain - Mus musculus (Mouse) - Col13a1 gene Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625). Indicus|evm.model.CM009518.1.158 Q9P0M6 H2AW_HUMAN 99.731 0.994638 1.00269 MACROH2A2 - Core histone macro-H2A.2 - Homo sapiens (Human) - MACROH2A2 gene Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. Indicus|evm.model.CM009518.1.159 A5PJM4 FSP1_BOVIN 99.732 0.994652 1.00268 AIFM2 - Ferroptosis suppressor protein 1 - Bos taurus (Bovine) - AIFM2 gene A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death. Capable of DNA binding in a non-sequence specific way. Indicus|evm.model.CM009518.1.160 Q2T9J0 TYSD1_HUMAN 81.777 0.863905 0.89576 TYSND1 - Peroxisomal leader peptide-processing protease - Homo sapiens (Human) - TYSND1 gene Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids. Indicus|evm.model.CM009518.1.161 Q52NJ3 SAR1A_PIG 100.000 0.98995 1.00505 SAR1A - GTP-binding protein SAR1a - Sus scrofa (Pig) - SAR1A gene Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity). Indicus|evm.model.CM009518.1.162 P37980 IPYR_BOVIN 100.000 0.993103 1.00346 PPA1 - Inorganic pyrophosphatase - Bos taurus (Bovine) - PPA1 gene cytosol, inorganic diphosphatase activity, magnesium ion binding, phosphate-containing compound metabolic process Indicus|evm.model.CM009518.1.163 Q9GZQ6 NPFF1_HUMAN 83.603 0.853755 1.17674 NPFFR1 - Neuropeptide FF receptor 1 - Homo sapiens (Human) - NPFFR1 gene Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009518.1.164 Q8TCA0 LRC20_HUMAN 91.848 0.989189 1.00543 LRRC20 - Leucine-rich repeat-containing protein 20 - Homo sapiens (Human) - LRRC20 gene Indicus|evm.model.CM009518.1.165 Q13542 4EBP2_HUMAN 99.167 0.983471 1.00833 EIF4EBP2 - Eukaryotic translation initiation factor 4E-binding protein 2 - Homo sapiens (Human) - EIF4EBP2 gene Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). Indicus|evm.model.CM009518.1.166 Q96S42 NODAL_HUMAN 85.345 0.994236 1 NODAL - Nodal homolog precursor - Homo sapiens (Human) - NODAL gene Essential for mesoderm formation and axial patterning during embryonic development. Indicus|evm.model.CM009518.1.167 Q9ULE6 PALD_HUMAN 85.676 0.913415 0.957944 PALD1 - Paladin - Homo sapiens (Human) - PALD1 gene cytoplasm, cytosol, protein tyrosine phosphatase activity Indicus|evm.model.CM009518.1.168 Q9ULE6 PALD_HUMAN 78.431 0.144286 0.817757 PALD1 - Paladin - Homo sapiens (Human) - PALD1 gene cytoplasm, cytosol, protein tyrosine phosphatase activity Indicus|evm.model.CM009518.1.169 Q8WXS8 ATS14_HUMAN 83.200 0.779783 0.905969 ADAMTS14 - A disintegrin and metalloproteinase with thrombospondin motifs 14 precursor - Homo sapiens (Human) - ADAMTS14 gene Has aminoprocollagen type I processing activity in the absence of ADAMTS2 (PubMed:11741898). Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (PubMed:11741898). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form (PubMed:31152061). Indicus|evm.model.CM009518.1.170 Q32KL8 TBATA_BOVIN 94.065 0.908108 1.11111 TBATA - Protein TBATA - Bos taurus (Bovine) - TBATA gene May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. Indicus|evm.model.CM009518.1.171 O95470 SGPL1_HUMAN 91.021 0.996485 1.00176 SGPL1 - Sphingosine-1-phosphate lyase 1 - Homo sapiens (Human) - SGPL1 gene Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). Indicus|evm.model.CM009518.1.172 Q3ZBD3 PHS_BOVIN 100.000 0.980952 1.00962 PCBD1 - Pterin-4-alpha-carbinolamine dehydratase - Bos taurus (Bovine) - PCBD1 gene Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Indicus|evm.model.CM009518.1.173 Q8IZJ1 UNC5B_HUMAN 95.238 0.997886 1.00106 UNC5B - Netrin receptor UNC5B precursor - Homo sapiens (Human) - UNC5B gene Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity). Indicus|evm.model.CM009518.1.174 A1A4N1 S29A3_BOVIN 98.529 0.948598 0.451477 SLC29A3 - Equilibrative nucleoside transporter 3 - Bos taurus (Bovine) - SLC29A3 gene Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity). Indicus|evm.model.CM009518.1.176 A1A4N1 S29A3_BOVIN 99.627 0.992565 0.567511 SLC29A3 - Equilibrative nucleoside transporter 3 - Bos taurus (Bovine) - SLC29A3 gene Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity). Indicus|evm.model.CM009518.1.177 Q9H251 CAD23_HUMAN 91.111 0.297297 0.0441264 CDH23 - Cadherin-23 precursor - Homo sapiens (Human) - CDH23 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Indicus|evm.model.CM009518.1.178 P58365 CAD23_RAT 94.709 0.989276 0.224902 Cdh23 - Cadherin-23 precursor - Rattus norvegicus (Rat) - Cdh23 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Indicus|evm.model.CM009518.1.179 Q9H7M9 VISTA_HUMAN 82.051 0.99359 1.00322 VSIR - V-type immunoglobulin domain-containing suppressor of T-cell activation precursor - Homo sapiens (Human) - VSIR gene Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). Indicus|evm.model.CM009518.1.180 Q99PF4 CAD23_MOUSE 93.214 0.997131 0.519678 Cdh23 - Cadherin-23 precursor - Mus musculus (Mouse) - Cdh23 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Indicus|evm.model.CM009518.1.181 P26779 SAP_BOVIN 99.619 0.996198 1.0019 PSAP - Prosaposin precursor - Bos taurus (Bovine) - PSAP gene Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Indicus|evm.model.CM009518.1.183 Q7LGC8 CHST3_HUMAN 88.382 0.995833 1.00209 CHST3 - Carbohydrate sulfotransferase 3 - Homo sapiens (Human) - CHST3 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. Indicus|evm.model.CM009518.1.184 Q92563 TICN2_HUMAN 97.170 0.995294 1.00236 SPOCK2 - Testican-2 precursor - Homo sapiens (Human) - SPOCK2 gene May participate in diverse steps of neurogenesis. Binds calcium. Indicus|evm.model.CM009518.1.185 Q9D8Z1 ASCC1_MOUSE 84.314 0.994413 1.00562 Ascc1 - Activating signal cointegrator 1 complex subunit 1 - Mus musculus (Mouse) - Ascc1 gene Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. Indicus|evm.model.CM009518.1.186 Q08E62 DDIT4_BOVIN 100.000 0.612903 1.62445 DDIT4 - DNA damage-inducible transcript 4 protein - Bos taurus (Bovine) - DDIT4 gene Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Indicus|evm.model.CM009518.1.187 Q58DR2 DJB12_BOVIN 96.757 0.965608 1.02162 DNAJB12 - DnaJ homolog subfamily B member 12 - Bos taurus (Bovine) - DNAJB12 gene Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear. Indicus|evm.model.CM009518.1.188 Q0IIL1 MICU1_BOVIN 100.000 0.995825 1.00209 MICU1 - Calcium uptake protein 1, mitochondrial precursor - Bos taurus (Bovine) - MICU1 gene Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Indicus|evm.model.CM009518.1.189 Q8NE86 MCU_HUMAN 98.575 0.994318 1.00285 MCU - Calcium uniporter protein, mitochondrial precursor - Homo sapiens (Human) - MCU gene Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276). participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity). Indicus|evm.model.CM009518.1.190 Q29RU2 OIT3_BOVIN 99.451 0.430952 0.767824 OIT3 - Oncoprotein-induced transcript 3 protein precursor - Bos taurus (Bovine) - OIT3 gene May be involved in hepatocellular function and development. Indicus|evm.model.CM009518.1.191 Q9BX93 PG12B_HUMAN 92.308 0.989796 1.00513 PLA2G12B - Group XIIB secretory phospholipase A2-like protein precursor - Homo sapiens (Human) - PLA2G12B gene Not known; does not seem to have catalytic activity. Indicus|evm.model.CM009518.1.192 Q1RMU3 P4HA1_BOVIN 98.127 0.996262 1.00187 P4HA1 - Prolyl 4-hydroxylase subunit alpha-1 precursor - Bos taurus (Bovine) - P4HA1 gene Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Indicus|evm.model.CM009518.1.193 Q86X67 NUD13_HUMAN 84.659 0.994334 1.00284 NUDT13 - NAD(P)H pyrophosphatase NUDT13, mitochondrial precursor - Homo sapiens (Human) - NUDT13 gene NAD(P)H pyrophosphatase that hydrolyzes NADH into NMNH and AMP, and NADPH into NMNH and 2',5'-ADP. Has a marked preference for the reduced pyridine nucleotides. Does not show activity toward NAD-capped RNAs; the NAD-cap is an atypical cap present at the 5'-end of some RNAs. Indicus|evm.model.CM009518.1.194 O95905 ECD_HUMAN 85.559 0.99689 0.998447 ECD - Protein ecdysoneless homolog - Homo sapiens (Human) - ECD gene Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). Indicus|evm.model.CM009518.1.195 A0JNF3 F149B_BOVIN 99.592 0.835897 1.19145 FAM149B1 - Primary cilium assembly protein FAM149B1 - Bos taurus (Bovine) - FAM149B1 gene Involved in the localization of proteins to the cilium and cilium assembly. Indirectly regulates the signaling functions of the cilium, being required for normal SHH/smoothened signaling and proper development. Indicus|evm.model.CM009518.1.196 Q8WXX5 DNJC9_HUMAN 95.062 0.927203 1.00385 DNAJC9 - DnaJ homolog subfamily C member 9 - Homo sapiens (Human) - DNAJC9 gene May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8. Indicus|evm.model.CM009518.1.197 P82915 RT16_BOVIN 100.000 0.985294 1.00741 MRPS16 - 28S ribosomal protein S16, mitochondrial precursor - Bos taurus (Bovine) - MRPS16 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Indicus|evm.model.CM009518.1.198 P20072 ANXA7_BOVIN 95.464 0.230257 4.53996 ANXA7 - Annexin A7 - Bos taurus (Bovine) - ANXA7 gene Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Indicus|evm.model.CM009518.1.199 P16298 PP2BB_HUMAN 99.091 0.981982 0.211832 PPP3CB - Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform - Homo sapiens (Human) - PPP3CB gene Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Indicus|evm.model.CM009518.1.200 P20651 PP2BB_RAT 100.000 0.964088 0.689524 Ppp3cb - Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform - Rattus norvegicus (Rat) - Ppp3cb gene Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Indicus|evm.model.CM009518.1.201 Q8BL06 UBP54_MOUSE 96.073 0.225444 1.06423 Usp54 - Inactive ubiquitin carboxyl-terminal hydrolase 54 - Mus musculus (Mouse) - Usp54 gene Has no peptidase activity. Indicus|evm.model.CM009518.1.202 Q8SQ24 MYOZ1_BOVIN 98.653 0.993197 0.989899 MYOZ1 - Myozenin-1 - Bos taurus (Bovine) - MYOZ1 gene Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). Indicus|evm.model.CM009518.1.203 Q9H987 SYP2L_HUMAN 88.586 0.988357 0.791198 SYNPO2L - Synaptopodin 2-like protein - Homo sapiens (Human) - SYNPO2L gene Actin-associated protein that may play a role in modulating actin-based shape. Indicus|evm.model.CM009518.1.204 P53992 SC24C_HUMAN 94.343 0.998174 1.00091 SEC24C - Protein transport protein Sec24C - Homo sapiens (Human) - SEC24C gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). Indicus|evm.model.CM009518.1.205 Q495W5 FUT11_HUMAN 91.121 0.955466 1.00407 FUT11 - Alpha-(1,3)-fucosyltransferase 11 - Homo sapiens (Human) - FUT11 gene Probable fucosyltransferase. Indicus|evm.model.CM009518.1.206 Q96BP2 CHCH1_HUMAN 85.593 0.983193 1.00847 CHCHD1 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 - Homo sapiens (Human) - CHCHD1 gene cytosol, fibrillar center, mitochondrial inner membrane, mitochondrion, nucleoplasm, RNA binding, mitochondrial translational elongation, mitochondrial translational termination Indicus|evm.model.CM009518.1.207 A7E305 ZSWM8_BOVIN 100.000 0.567612 1.29795 ZSWIM8 - Zinc finger SWIM domain-containing protein 8 - Bos taurus (Bovine) - ZSWIM8 gene Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation. Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target. May also acts as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation. Indicus|evm.model.CM009518.1.208 O97583 NDST2_BOVIN 97.851 0.997738 1 NDST2 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 - Bos taurus (Bovine) - NDST2 gene Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Indicus|evm.model.CM009518.1.209 Q923T9 KCC2G_MOUSE 96.512 0.976744 0.975425 Camk2g - Calcium/calmodulin-dependent protein kinase type II subunit gamma - Mus musculus (Mouse) - Camk2g gene Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning (By similarity) (PubMed:30184290). Indicus|evm.model.CM009518.1.210 Q05589 UROK_BOVIN 100.000 0.995392 1.00231 PLAU - Urokinase-type plasminogen activator precursor - Bos taurus (Bovine) - PLAU gene Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Indicus|evm.model.CM009518.1.211 Q5R9E5 FA32A_PONAB 81.416 0.982301 1.00893 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Indicus|evm.model.CM009518.1.212 P26234 VINC_PIG 99.295 0.998238 1 VCL - Vinculin - Sus scrofa (Pig) - VCL gene Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Indicus|evm.model.CM009518.1.213 Q5R478 AP3M1_PONAB 100.000 0.995227 1.00239 AP3M1 - AP-3 complex subunit mu-1 - Pongo abelii (Sumatran orangutan) - AP3M1 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). Indicus|evm.model.CM009518.1.215 P83732 RL24_RAT 64.375 0.986842 0.968153 Rpl24 - 60S ribosomal protein L24 - Rattus norvegicus (Rat) - Rpl24 gene cytoplasm, cytosolic large ribosomal subunit, cytosolic ribosome, polysomal ribosome, synapse, RNA binding, structural constituent of ribosome, assembly of large subunit precursor of preribosome, cytoplasmic translation, exit from mitosis Indicus|evm.model.CM009518.1.216 Q8WML3 KAT6B_MACFA 98.387 0.198184 1.04933 KAT6B - Histone acetyltransferase KAT6B - Macaca fascicularis (Crab-eating macaque) - KAT6B gene Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Indicus|evm.model.CM009518.1.217 P0C591 DUS29_BOVIN 100.000 0.931624 1.06849 DUSP29 - Dual specificity phosphatase 29 - Bos taurus (Bovine) - DUSP29 gene Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of intracellular signaling cascades. May regulate glucose metabolism by activating, AMPK, an energy sensor protein kinase. Affects MAP kinase signaling though modulation of the ERK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (By similarity). Indicus|evm.model.CM009518.1.218 Q9UII6 DS13B_HUMAN 92.424 0.451835 2.20202 DUSP13 - Dual specificity protein phosphatase 13 isoform B - Homo sapiens (Human) - DUSP13 gene Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro (PubMed:21360282). Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro (PubMed:10585869). Indicus|evm.model.CM009518.1.219 Q96LT4 SAMD8_HUMAN 97.590 0.864301 1.15422 SAMD8 - Sphingomyelin synthase-related protein 1 - Homo sapiens (Human) - SAMD8 gene Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. Indicus|evm.model.CM009518.1.220 P68002 VDAC2_BOVIN 100.000 0.832386 1.19728 VDAC2 - Voltage-dependent anion-selective channel protein 2 - Bos taurus (Bovine) - VDAC2 gene Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity). Binding of ceramide promotes the Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity). Indicus|evm.model.CM009518.1.221 Q86VU5 CMTD1_HUMAN 88.168 0.992395 1.00382 COMTD1 - Catechol O-methyltransferase domain-containing protein 1 - Homo sapiens (Human) - COMTD1 gene Putative O-methyltransferase. Indicus|evm.model.CM009518.1.222 Q3ZBX1 PIGC_BOVIN 89.686 0.991071 0.754209 PIGC - Phosphatidylinositol N-acetylglucosaminyltransferase subunit C - Bos taurus (Bovine) - PIGC gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Indicus|evm.model.CM009518.1.224 Q7TMA2 ZN503_MOUSE 100.000 0.140449 0.819018 Znf503 - Zinc finger protein 503 - Mus musculus (Mouse) - Znf503 gene May function as a transcriptional repressor. Indicus|evm.model.CM009518.1.225 Q9H2I8 LRMDA_HUMAN 80.952 0.693333 0.757576 LRMDA - Leucine-rich melanocyte differentiation-associated protein - Homo sapiens (Human) - LRMDA gene Required for melanocyte differentiation. Indicus|evm.model.CM009518.1.226 P62907 RL10A_RAT 92.784 0.984694 0.903226 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Indicus|evm.model.CM009518.1.227 Q28204 KCMA1_BOVIN 99.904 0.976636 0.917667 KCNMA1 - Calcium-activated potassium channel subunit alpha-1 - Bos taurus (Bovine) - KCNMA1 gene Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity). Indicus|evm.model.CM009518.1.228 Q8TDM6 DLG5_HUMAN 93.597 0.998959 1.00104 DLG5 - Disks large homolog 5 - Homo sapiens (Human) - DLG5 gene Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). Indicus|evm.model.CM009518.1.229 A4IF62 RPC1_BOVIN 100.000 0.998562 1.00072 POLR3A - DNA-directed RNA polymerase III subunit RPC1 - Bos taurus (Bovine) - POLR3A gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Indicus|evm.model.CM009518.1.230 Q5RAQ8 RS24_PONAB 100.000 0.977444 1.01527 RPS24 - 40S ribosomal protein S24 - Pongo abelii (Sumatran orangutan) - RPS24 gene Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Indicus|evm.model.CM009518.1.239 Q9ULJ6 ZMIZ1_HUMAN 100.000 0.255495 0.341143 ZMIZ1 - Zinc finger MIZ domain-containing protein 1 - Homo sapiens (Human) - ZMIZ1 gene Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (PubMed:30639322). Indicus|evm.model.CM009518.1.240 Q9ULJ6 ZMIZ1_HUMAN 94.882 0.958969 0.982193 ZMIZ1 - Zinc finger MIZ domain-containing protein 1 - Homo sapiens (Human) - ZMIZ1 gene Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (PubMed:30639322). Indicus|evm.model.CM009518.1.241 P30404 PPIF_BOVIN 100.000 0.990431 1.00481 PPIF - Peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor - Bos taurus (Bovine) - PPIF gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (By similarity). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (By similarity). Indicus|evm.model.CM009518.1.242 B2RVL6 ZCH24_MOUSE 97.487 0.985075 0.834025 Zcchc24 - Zinc finger CCHC domain-containing protein 24 - Mus musculus (Mouse) - Zcchc24 gene Indicus|evm.model.CM009518.1.244 P27214 ANX11_BOVIN 95.825 0.995876 0.964215 ANXA11 - Annexin A11 - Bos taurus (Bovine) - ANXA11 gene Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis. Indicus|evm.model.CM009518.1.245 Q2TBK3 PLAC9_BOVIN 98.000 0.980198 1.01 PLAC9 - Placenta-specific protein 9 precursor - Bos taurus (Bovine) - PLAC9 gene Indicus|evm.model.CM009518.1.246 Q0D2G3 TM254_BOVIN 100.000 0.938931 1.05645 TMEM254 - Transmembrane protein 254 - Bos taurus (Bovine) - TMEM254 gene Indicus|evm.model.CM009518.1.247 A4FUH5 NDUF4_BOVIN 77.083 0.903846 0.297143 NDUFAF4 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 - Bos taurus (Bovine) - NDUFAF4 gene Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion (By similarity). Indicus|evm.model.CM009518.1.248 P23805 CONG_BOVIN 99.461 0.994624 1.0027 CGN1 - Conglutinin precursor - Bos taurus (Bovine) - CGN1 gene Calcium-dependent lectin-like protein which binds to a yeast cell wall extract and immune complexes through the complement component (C3bi). It is capable of binding non-reducing terminal N-acetylglucosamine, mannose, and fucose residues. Indicus|evm.model.CM009518.1.249 P42916 CL43_BOVIN 91.667 0.141129 0.772586 CL43 - Collectin-43 precursor - Bos taurus (Bovine) - CL43 gene Lectin that binds to various sugars: mannose = ManNAc > fucose > GlcNAc > glucose = maltose > galactose > lactose > GalNAc. Could play a role in immune defense. Indicus|evm.model.CM009518.1.250 Q8MHZ9 CL46_BOVIN 98.246 0.423881 1.80593 CL46 - Collectin-46 precursor - Bos taurus (Bovine) - CL46 gene extracellular space, multivesicular body, rough endoplasmic reticulum, positive regulation of phagocytosis, surfactant homeostasis Indicus|evm.model.CM009518.1.251 P42916 CL43_BOVIN 76.129 0.951389 0.897196 CL43 - Collectin-43 precursor - Bos taurus (Bovine) - CL43 gene Lectin that binds to various sugars: mannose = ManNAc > fucose > GlcNAc > glucose = maltose > galactose > lactose > GalNAc. Could play a role in immune defense. Indicus|evm.model.CM009518.1.252 P35246 SFTPD_BOVIN 99.458 0.994595 1.00271 SFTPD - Pulmonary surfactant-associated protein D precursor - Bos taurus (Bovine) - SFTPD gene Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. Indicus|evm.model.CM009518.1.253 Q6RXL1 SFTPA_BOVIN 99.194 0.501014 1.9879 SFTPA1 - Pulmonary surfactant-associated protein A precursor - Bos taurus (Bovine) - SFTPA1 gene In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. Indicus|evm.model.CM009518.1.254 Q2KJC6 METK1_BOVIN 99.747 0.994962 1.00253 MAT1A - S-adenosylmethionine synthase isoform type-1 - Bos taurus (Bovine) - MAT1A gene Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Indicus|evm.model.CM009518.1.255 Q32LH1 DYDC1_BOVIN 99.429 0.988636 1.00571 DYDC1 - DPY30 domain-containing protein 1 - Bos taurus (Bovine) - DYDC1 gene Plays a crucial role during acrosome biogenesis. Indicus|evm.model.CM009518.1.256 Q2KIW3 DYDC2_BOVIN 99.485 0.989744 1.00515 DYDC2 - DPY30 domain-containing protein 2 - Bos taurus (Bovine) - DYDC2 gene Set1C/COMPASS complex, chromatin silencing at telomere, histone H3-K4 methylation Indicus|evm.model.CM009518.1.257 Q3ZBK2 PXL2A_BOVIN 99.541 0.628986 1.58257 PRXL2A - Peroxiredoxin-like 2A - Bos taurus (Bovine) - PRXL2A gene Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway. Indicus|evm.model.CM009518.1.258 Q8NG11 TSN14_HUMAN 91.852 0.992126 0.940741 TSPAN14 - Tetraspanin-14 - Homo sapiens (Human) - TSPAN14 gene Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). Indicus|evm.model.CM009518.1.259 Q5SQS7 SH24B_HUMAN 94.412 0.673956 1.16705 SH2D4B - SH2 domain-containing protein 4B - Homo sapiens (Human) - SH2D4B gene cytoplasm Indicus|evm.model.CM009518.1.260 P23438 SSRB_CANLF 59.375 0.983051 0.644809 SSR2 - Translocon-associated protein subunit beta precursor - Canis lupus familiaris (Dog) - SSR2 gene TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Indicus|evm.model.CM009518.1.261 P56975 NRG3_HUMAN 96.988 0.833333 0.275 NRG3 - Pro-neuregulin-3, membrane-bound isoform precursor - Homo sapiens (Human) - NRG3 gene Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. Indicus|evm.model.CM009518.1.262 P56975 NRG3_HUMAN 93.284 0.995025 0.558333 NRG3 - Pro-neuregulin-3, membrane-bound isoform precursor - Homo sapiens (Human) - NRG3 gene Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. Indicus|evm.model.CM009518.1.263 Q9GZN1 ARP6_HUMAN 87.597 0.984615 0.328283 ACTR6 - Actin-related protein 6 - Homo sapiens (Human) - ACTR6 gene nucleus, Swr1 complex, nucleosome binding, histone exchange Indicus|evm.model.CM009518.1.264 P13696 PEBP1_BOVIN 65.730 0.899329 0.796791 PEBP1 - Phosphatidylethanolamine-binding protein 1 - Bos taurus (Bovine) - PEBP1 gene Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Indicus|evm.model.CM009518.1.265 Q9HCE3 ZN532_HUMAN 88.112 0.946667 0.115296 ZNF532 - Zinc finger protein 532 - Homo sapiens (Human) - ZNF532 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009518.1.266 Q9H3K2 GHITM_HUMAN 93.623 0.99422 1.0029 GHITM - Growth hormone-inducible transmembrane protein precursor - Homo sapiens (Human) - GHITM gene Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. Indicus|evm.model.CM009518.1.267 I3LGZ3 GL15L_PIG 72.840 0.97561 1.01235 GPRL15 - Protein GPR15L precursor - Sus scrofa (Pig) - GPRL15 gene Chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). Indicus|evm.model.CM009518.1.268 Q8WN91 CDHR1_BOVIN 99.769 0.997696 1.00115 CDHR1 - Cadherin-related family member 1 precursor - Bos taurus (Bovine) - CDHR1 gene Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). Indicus|evm.model.CM009518.1.269 A6NDA9 LRIT2_HUMAN 78.040 0.976868 1.02182 LRIT2 - Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 precursor - Homo sapiens (Human) - LRIT2 gene Indicus|evm.model.CM009518.1.270 Q8K099 LRIT1_MOUSE 80.609 0.99679 0.998397 Lrit1 - Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 precursor - Mus musculus (Mouse) - Lrit1 gene Possible role in phototransduction. Indicus|evm.model.CM009518.1.271 P47803 RGR_BOVIN 100.000 0.993151 1.00344 RGR - RPE-retinal G protein-coupled receptor - Bos taurus (Bovine) - RGR gene Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism. Indicus|evm.model.CM009518.1.272 P08166 KAD2_BOVIN 93.991 0.987234 0.975104 AK2 - Adenylate kinase 2, mitochondrial - Bos taurus (Bovine) - AK2 gene Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. Indicus|evm.model.CM009518.1.273 Q9H7U1 CCSE2_HUMAN 90.048 0.997605 1.0012 CCSER2 - Serine-rich coiled-coil domain-containing protein 2 - Homo sapiens (Human) - CCSER2 gene Microtubule-binding protein which might play a role in microtubule bundling. Indicus|evm.model.CM009518.1.278 Q9ULK0 GRID1_HUMAN 99.287 0.973214 0.999009 GRID1 - Glutamate receptor ionotropic, delta-1 precursor - Homo sapiens (Human) - GRID1 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Indicus|evm.model.CM009518.1.280 Q7Z5K2 WAPL_HUMAN 94.900 0.927626 1.07983 WAPL - Wings apart-like protein homolog - Homo sapiens (Human) - WAPL gene Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Indicus|evm.model.CM009518.1.281 Q9JKS4 LDB3_MOUSE 85.302 0.594728 1.67911 Ldb3 - LIM domain-binding protein 3 - Mus musculus (Mouse) - Ldb3 gene May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. Indicus|evm.model.CM009518.1.283 P36894 BMR1A_HUMAN 98.308 0.996248 1.00188 BMPR1A - Bone morphogenetic protein receptor type-1A precursor - Homo sapiens (Human) - BMPR1A gene On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. Indicus|evm.model.CM009518.1.284 Q9H8L6 MMRN2_HUMAN 75.053 0.997856 0.98314 MMRN2 - Multimerin-2 precursor - Homo sapiens (Human) - MMRN2 gene Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. Indicus|evm.model.CM009518.1.285 Q9NZ50 SYUG_BOVIN 100.000 0.984375 1.00787 SNCG - Gamma-synuclein - Bos taurus (Bovine) - SNCG gene Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. Indicus|evm.model.CM009518.1.286 Q15847 ADIRF_HUMAN 85.526 0.974026 1.01316 ADIRF - Adipogenesis regulatory factor - Homo sapiens (Human) - ADIRF gene Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. Indicus|evm.model.CM009518.1.288 P00366 DHE3_BOVIN 97.326 0.996441 1.00717 GLUD1 - Glutamate dehydrogenase 1, mitochondrial precursor - Bos taurus (Bovine) - GLUD1 gene Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:4365183, PubMed:14659072). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). Indicus|evm.model.CM009518.1.289 Q86V20 SHLD2_HUMAN 76.216 0.207207 1.06347 SHLD2 - Shieldin complex subunit 2 - Homo sapiens (Human) - SHLD2 gene Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). Indicus|evm.model.CM009518.1.290 Q9BQS2 SYT15_HUMAN 78.385 0.995181 0.985748 SYT15 - Synaptotagmin-15 - Homo sapiens (Human) - SYT15 gene May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Indicus|evm.model.CM009518.1.291 O60269 GRIN2_HUMAN 77.511 0.995595 0.991266 GPRIN2 - G protein-regulated inducer of neurite outgrowth 2 - Homo sapiens (Human) - GPRIN2 gene May be involved in neurite outgrowth. Indicus|evm.model.CM009518.1.293 P50391 NPY4R_HUMAN 86.207 0.994709 1.008 NPY4R - Neuropeptide Y receptor type 4 - Homo sapiens (Human) - NPY4R gene Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid. Indicus|evm.model.CM009518.1.294 Q9CPX9 APC11_MOUSE 97.468 0.95122 0.97619 Anapc11 - Anaphase-promoting complex subunit 11 - Mus musculus (Mouse) - Anapc11 gene Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). Indicus|evm.model.CM009518.1.295 Q95L54 ANXA8_BOVIN 100.000 0.993902 1.00306 ANXA8 - Annexin A8 - Bos taurus (Bovine) - ANXA8 gene This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Indicus|evm.model.CM009518.1.296 Q9H6X2 ANTR1_HUMAN 48.780 0.489655 1.02837 ANTXR1 - Anthrax toxin receptor 1 precursor - Homo sapiens (Human) - ANTXR1 gene Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. Indicus|evm.model.CM009518.1.304 Q8BZ97 PRDM8_MOUSE 72.340 0.141538 0.473071 Prdm8 - PR domain zinc finger protein 8 - Mus musculus (Mouse) - Prdm8 gene Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (PubMed:19646955). Histone methyltransferase activity has not been confirmed in other species. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (PubMed:19646955). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (PubMed:22284184). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (PubMed:26023183). Indicus|evm.model.CM009518.1.305 P12661 RET3_BOVIN 99.533 0.998446 1.00078 RBP3 - Retinol-binding protein 3 precursor - Bos taurus (Bovine) - RBP3 gene IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Indicus|evm.model.CM009518.1.306 Q9UK05 GDF2_HUMAN 80.046 0.99537 1.00699 GDF2 - Growth/differentiation factor 2 precursor - Homo sapiens (Human) - GDF2 gene Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. Indicus|evm.model.CM009518.1.307 Q5R893 H2B1_PONAB 93.750 0.822222 1.07143 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009518.1.308 Q08DX6 GDF10_BOVIN 100.000 0.995825 1.00209 GDF10 - Growth/differentiation factor 10 precursor - Bos taurus (Bovine) - GDF10 gene Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. Indicus|evm.model.CM009518.1.309 Q4JDL3 PTN20_HUMAN 66.581 0.874715 1.04524 PTPN20 - Tyrosine-protein phosphatase non-receptor type 20 - Homo sapiens (Human) - PTPN20 gene Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates. Indicus|evm.model.CM009518.1.310 Q6IN97 FRP2L_HUMAN 77.104 0.210337 4.35313 FRMPD2B - Putative protein FRMPD2-like - Homo sapiens (Human) - FRMPD2B gene Indicus|evm.model.CM009518.1.311 P45983 MK08_HUMAN 99.297 0.995327 1.00234 MAPK8 - Mitogen-activated protein kinase 8 - Homo sapiens (Human) - MAPK8 gene Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:18307971). Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins (PubMed:21856198). Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1 (PubMed:21364637). In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation (PubMed:21095239). Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy (PubMed:18570871). Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH (PubMed:20027304, PubMed:17296730, PubMed:16581800). Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly (PubMed:22966201). Indicus|evm.model.CM009518.1.313 Q6ZS81 WDFY4_HUMAN 83.192 0.99936 0.981784 WDFY4 - WD repeat- and FYVE domain-containing protein 4 - Homo sapiens (Human) - WDFY4 gene Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Plays also a role in B-cell survival through regulation of autophagy. Indicus|evm.model.CM009518.1.314 Q8IW00 VSTM4_HUMAN 91.060 0.958466 0.978125 VSTM4 - V-set and transmembrane domain-containing protein 4 precursor - Homo sapiens (Human) - VSTM4 gene Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors. Indicus|evm.model.CM009518.1.315 A6NMN3 F170B_HUMAN 68.056 0.989655 1.02473 FAM170B - Protein FAM170B - Homo sapiens (Human) - FAM170B gene Plays a role in fertilization through the acrosome reaction. Indicus|evm.model.CM009518.1.316 Q5T292 TM273_HUMAN 68.354 0.75 0.990476 TMEM273 - Transmembrane protein 273 precursor - Homo sapiens (Human) - TMEM273 gene Indicus|evm.model.CM009518.1.317 Q711Q0 CEFIP_HUMAN 71.359 0.998606 1 CEFIP - Cardiac-enriched FHL2-interacting protein - Homo sapiens (Human) - CEFIP gene Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Indicus|evm.model.CM009518.1.318 A6NNA5 DRGX_HUMAN 95.817 0.992424 1.0038 DRGX - Dorsal root ganglia homeobox protein - Homo sapiens (Human) - DRGX gene Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. Indicus|evm.model.CM009518.1.319 Q03468 ERCC6_HUMAN 76.099 0.998642 0.986604 ERCC6 - DNA excision repair protein ERCC-6 - Homo sapiens (Human) - ERCC6 gene Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:20541997, PubMed:26620705, PubMed:16246722). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). It is required for transcription-coupled repair complex formation (PubMed:16916636). It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-blocking lesions (PubMed:16916636). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function. Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). Indicus|evm.model.CM009518.1.320 Q16572 VACHT_HUMAN 87.218 0.99619 0.986842 SLC18A3 - Vesicular acetylcholine transporter - Homo sapiens (Human) - SLC18A3 gene Involved in acetylcholine transport into synaptic vesicles. Indicus|evm.model.CM009518.1.321 P13222 CLAT_PIG 85.358 0.954911 0.968799 CHAT - Choline O-acetyltransferase - Sus scrofa (Pig) - CHAT gene Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Indicus|evm.model.CM009518.1.322 P0C920 CJ053_BOVIN 100.000 0.978723 1.01075 UPF0728 protein C10orf53 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009518.1.323 Q9ULD0 OGDHL_HUMAN 94.851 0.998022 1.00099 OGDHL - 2-oxoglutarate dehydrogenase-like, mitochondrial precursor - Homo sapiens (Human) - OGDHL gene 2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH (By similarity). The OGDHC complex is mainly active in the mitochondrion (By similarity). Involved in the inhibition of cell proliferation and in apoptosis (PubMed:23152800, PubMed:31175094). Indicus|evm.model.CM009518.1.324 O02776 PARG_BOVIN 99.795 0.997955 1.00102 PARG - Poly(ADP-ribose) glycohydrolase - Bos taurus (Bovine) - PARG gene Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15658938). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Indicus|evm.model.CM009518.1.325 A4IFL0 TIM23_BOVIN 100.000 0.990476 1.00478 TIMM23 - Mitochondrial import inner membrane translocase subunit Tim23 - Bos taurus (Bovine) - TIMM23 gene Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Indicus|evm.model.CM009518.1.326 Q13772 NCOA4_HUMAN 82.456 0.99681 1.02117 NCOA4 - Nuclear receptor coactivator 4 - Homo sapiens (Human) - NCOA4 gene Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Indicus|evm.model.CM009518.1.327 O02826 MSMB_PIG 67.308 0.715278 1.2973 MSMB - Beta-microseminoprotein precursor - Sus scrofa (Pig) - MSMB gene Indicus|evm.model.CM009518.1.328 Q641Q2 WAC2A_HUMAN 79.508 0.998501 0.99478 WASHC2A - WASH complex subunit 2A - Homo sapiens (Human) - WASHC2A gene Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. Indicus|evm.model.CM009518.1.329 D3Z3C6 ZFAN4_MOUSE 77.343 0.997207 0.968877 Zfand4 - AN1-type zinc finger protein 4 - Mus musculus (Mouse) - Zfand4 gene Indicus|evm.model.CM009518.1.330 Q0VD59 MARH8_BOVIN 100.000 0.993103 1.00346 MARCHF8 - E3 ubiquitin-protein ligase MARCHF8 - Bos taurus (Bovine) - MARCHF8 gene E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS. Indicus|evm.model.CM009518.1.331 P09917 LOX5_HUMAN 91.988 0.997037 1.00148 ALOX5 - Polyunsaturated fatty acid 5-lipoxygenase - Homo sapiens (Human) - ALOX5 gene Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:8631361, PubMed:21233389, PubMed:22516296, PubMed:24282679, PubMed:19022417, PubMed:23246375, PubMed:8615788, PubMed:24893149, PubMed:31664810). Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE) (PubMed:23246375). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (PubMed:31664810). Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:21206090, PubMed:31664810, PubMed:8615788, PubMed:17114001, PubMed:32404334). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (By similarity). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31664810). In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (By similarity). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21200133). Also may play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity). Indicus|evm.model.CM009518.1.332 Q1LZC0 ZNF22_BOVIN 100.000 0.99115 1.00444 ZNF22 - Zinc finger protein 22 - Bos taurus (Bovine) - ZNF22 gene Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity). Indicus|evm.model.CM009518.1.333 Q9H2L5 RASF4_HUMAN 84.112 0.686147 1.43925 RASSF4 - Ras association domain-containing protein 4 - Homo sapiens (Human) - RASSF4 gene Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest. Indicus|evm.model.CM009518.1.334 A0PK05 TMM72_HUMAN 86.923 0.992308 0.945455 TMEM72 - Transmembrane protein 72 - Homo sapiens (Human) - TMEM72 gene Indicus|evm.model.CM009518.1.337 P48061 SDF1_HUMAN 92.135 0.733333 1.29032 CXCL12 - Stromal cell-derived factor 1 precursor - Homo sapiens (Human) - CXCL12 gene Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity). Indicus|evm.model.CM009518.1.342 Q02543 RL18A_HUMAN 45.714 0.942857 0.596591 RPL18A - 60S ribosomal protein L18a - Homo sapiens (Human) - RPL18A gene cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing Indicus|evm.model.CM009518.1.343 P17041 ZNF32_HUMAN 97.802 0.992701 1.00366 ZNF32 - Zinc finger protein 32 - Homo sapiens (Human) - ZNF32 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009518.1.345 Q16600 ZN239_HUMAN 79.259 0.992593 0.884279 ZNF239 - Zinc finger protein 239 - Homo sapiens (Human) - ZNF239 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009518.1.346 Q0II87 TFAM_BOVIN 99.593 0.991903 1.00407 TFAM - Transcription factor A, mitochondrial precursor - Bos taurus (Bovine) - TFAM gene Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. Indicus|evm.model.CM009518.1.347 O35920 CAN9_RAT 88.889 0.238532 0.157971 Capn9 - Calpain-9 - Rattus norvegicus (Rat) - Capn9 gene Calcium-regulated non-lysosomal thiol-protease. Indicus|evm.model.CM009518.1.348 P01017 ANGT_BOVIN 99.370 0.916988 1.08824 AGT - Angiotensinogen precursor - Bos taurus (Bovine) - AGT gene Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Indicus|evm.model.CM009518.1.349 Q14746 COG2_HUMAN 89.445 0.997297 1.00271 COG2 - Conserved oligomeric Golgi complex subunit 2 - Homo sapiens (Human) - COG2 gene Required for normal Golgi morphology and function. Indicus|evm.model.CM009519.1.2 Q9BQI4 CCDC3_HUMAN 79.412 0.705263 0.351852 CCDC3 - Coiled-coil domain-containing protein 3 precursor - Homo sapiens (Human) - CCDC3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity). Indicus|evm.model.CM009519.1.3 Q9UPS8 ANR26_HUMAN 73.077 0.908451 0.0830409 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009519.1.4 Q63610 TPM3_RAT 95.968 0.991968 1.00403 Tpm3 - Tropomyosin alpha-3 chain - Rattus norvegicus (Rat) - Tpm3 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Indicus|evm.model.CM009519.1.5 Q9UPS8 ANR26_HUMAN 62.554 0.982719 0.507602 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Indicus|evm.model.CM009519.1.6 Q96RD7 PANX1_HUMAN 82.201 0.995294 0.997653 PANX1 - Pannexin-1 - Homo sapiens (Human) - PANX1 gene Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). Plays a critical role in oogenesis (PubMed:30918116). Indicus|evm.model.CM009519.1.7 Q6MZM0 HPHL1_HUMAN 89.402 0.99728 0.951682 HEPHL1 - Ferroxidase HEPHL1 precursor - Homo sapiens (Human) - HEPHL1 gene Is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe(2+) to Fe(3+) without releasing radical oxygen species (PubMed:31125343). May be involved in the regulation of intracellular iron content (PubMed:31125343). Indicus|evm.model.CM009519.1.9 A8MXK1 VSTM5_HUMAN 89.941 0.938547 0.895 VSTM5 - V-set and transmembrane domain-containing protein 5 precursor - Homo sapiens (Human) - VSTM5 gene Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain. Indicus|evm.model.CM009519.1.10 Q5BIR6 MED17_BOVIN 100.000 0.996933 1.00154 MED17 - Mediator of RNA polymerase II transcription subunit 17 - Bos taurus (Bovine) - MED17 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Indicus|evm.model.CM009519.1.11 Q2HJH3 CK054_BOVIN 99.683 0.993671 1.00317 Ester hydrolase C11orf54 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.12 Q32LB6 TAF1D_BOVIN 100.000 0.992727 1.00365 TAF1D - TATA box-binding protein-associated factor RNA polymerase I subunit D - Bos taurus (Bovine) - TAF1D gene Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity). Indicus|evm.model.CM009519.1.13 Q9C0D2 CE295_HUMAN 69.251 0.978186 1.00461 CEP295 - Centrosomal protein of 295 kDa - Homo sapiens (Human) - CEP295 gene Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865). Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). Indicus|evm.model.CM009519.1.15 Q95JK1 DEUP1_MACFA 84.477 0.986755 1.00166 DEUP1 - Deuterosome assembly protein 1 - Macaca fascicularis (Crab-eating macaque) - DEUP1 gene Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). Indicus|evm.model.CM009519.1.16 Q6YBV0 S36A4_HUMAN 92.577 0.995885 0.964286 SLC36A4 - Proton-coupled amino acid transporter 4 - Homo sapiens (Human) - SLC36A4 gene Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine. Indicus|evm.model.CM009519.1.17 P49286 MTR1B_HUMAN 75.824 0.962865 1.04144 MTNR1B - Melatonin receptor type 1B - Homo sapiens (Human) - MTNR1B gene High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Indicus|evm.model.CM009519.1.18 P68105 EF1A1_RABIT 79.854 0.953545 0.885281 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009519.1.19 Q8TDW7 FAT3_HUMAN 93.163 0.995518 0.734474 FAT3 - Protocadherin Fat 3 precursor - Homo sapiens (Human) - FAT3 gene May play a role in the interactions between neurites derived from specific subsets of neurons during development. Indicus|evm.model.CM009519.1.20 Q8TDW7 FAT3_HUMAN 94.231 0.427386 0.0528857 FAT3 - Protocadherin Fat 3 precursor - Homo sapiens (Human) - FAT3 gene May play a role in the interactions between neurites derived from specific subsets of neurons during development. Indicus|evm.model.CM009519.1.21 Q2NKY7 SEPT2_BOVIN 81.633 0.820225 0.493075 SEPTIN2 - Septin-2 - Bos taurus (Bovine) - SEPTIN2 gene Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein (By similarity). Indicus|evm.model.CM009519.1.23 Q8TDW7 FAT3_HUMAN 93.352 0.970771 0.247751 FAT3 - Protocadherin Fat 3 precursor - Homo sapiens (Human) - FAT3 gene May play a role in the interactions between neurites derived from specific subsets of neurons during development. Indicus|evm.model.CM009519.1.25 Q2T9M4 DRC7_BOVIN 88.679 0.436975 0.136468 DRC7 - Dynein regulatory complex subunit 7 - Bos taurus (Bovine) - DRC7 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility. Indicus|evm.model.CM009519.1.26 P08166 KAD2_BOVIN 67.586 0.985816 0.585062 AK2 - Adenylate kinase 2, mitochondrial - Bos taurus (Bovine) - AK2 gene Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. Indicus|evm.model.CM009519.1.27 Q29RL2 CHRD1_BOVIN 100.000 0.993994 1.00301 CHORDC1 - Cysteine and histidine-rich domain-containing protein 1 - Bos taurus (Bovine) - CHORDC1 gene Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response. Prevents tumorigenesis (By similarity). Indicus|evm.model.CM009519.1.28 Q9Y3Q0 NALD2_HUMAN 87.852 0.965616 0.943243 NAALAD2 - N-acetylated-alpha-linked acidic dipeptidase 2 - Homo sapiens (Human) - NAALAD2 gene Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate. Indicus|evm.model.CM009519.1.29 P0CB47 UBFL1_HUMAN 61.473 0.410317 2.17048 UBTFL1 - Upstream-binding factor 1-like protein 1 - Homo sapiens (Human) - UBTFL1 gene Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development. Indicus|evm.model.CM009519.1.30 Q9D2X5 SCC4_MOUSE 70.833 0.534091 0.142165 Mau2 - MAU2 chromatid cohesion factor homolog - Mus musculus (Mouse) - Mau2 gene Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodim. eric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin Plays a role in sister chromatid cohesion and normal progression through prometaphase. Indicus|evm.model.CM009519.1.31 A6NGJ6 TRI64_HUMAN 60.134 0.988962 1.00891 TRIM64 - Tripartite motif-containing protein 64 - Homo sapiens (Human) - TRIM64 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Indicus|evm.model.CM009519.1.32 A3QJZ7 PRA27_HUMAN 44.262 0.434783 0.288703 PRAMEF27 - PRAME family member 27 - Homo sapiens (Human) - PRAMEF27 gene cytoplasm Indicus|evm.model.CM009519.1.33 Q5VT98 PRA20_HUMAN 50.756 0.974522 0.991579 PRAMEF20 - PRAME family member 20 - Homo sapiens (Human) - PRAMEF20 gene cytoplasm Indicus|evm.model.CM009519.1.34 Q5VTA0 PRA17_HUMAN 66.667 0.261146 0.331224 PRAMEF17 - PRAME family member 17 - Homo sapiens (Human) - PRAMEF17 gene cytoplasm Indicus|evm.model.CM009519.1.35 P25976 UBF1_MOUSE 57.018 0.511312 0.288889 Ubtf - Nucleolar transcription factor 1 - Mus musculus (Mouse) - Ubtf gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Indicus|evm.model.CM009519.1.36 A6NGJ6 TRI64_HUMAN 52.235 0.56383 1.67483 TRIM64 - Tripartite motif-containing protein 64 - Homo sapiens (Human) - TRIM64 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Indicus|evm.model.CM009519.1.37 P25977 UBF1_RAT 59.231 0.361345 0.467277 Ubtf - Nucleolar transcription factor 1 - Rattus norvegicus (Rat) - Ubtf gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (By similarity). Indicus|evm.model.CM009519.1.39 P0CB47 UBFL1_HUMAN 52.778 0.844595 0.753181 UBTFL1 - Upstream-binding factor 1-like protein 1 - Homo sapiens (Human) - UBTFL1 gene Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development. Indicus|evm.model.CM009519.1.40 A6NGJ6 TRI64_HUMAN 62.369 0.260237 2.44766 TRIM64 - Tripartite motif-containing protein 64 - Homo sapiens (Human) - TRIM64 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Indicus|evm.model.CM009519.1.42 P25977 UBF1_RAT 61.404 0.270983 0.545812 Ubtf - Nucleolar transcription factor 1 - Rattus norvegicus (Rat) - Ubtf gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (By similarity). Indicus|evm.model.CM009519.1.43 A6NI03 TR64B_HUMAN 53.416 0.721461 0.487751 TRIM64B - Putative tripartite motif-containing protein 64B - Homo sapiens (Human) - TRIM64B gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Indicus|evm.model.CM009519.1.44 P25980 UBF1B_XENLA 65.000 0.128261 0.656205 ubtf-b - Nucleolar transcription factor 1-B - Xenopus laevis (African clawed frog) - ubtf-b gene UBF recognizes the ribosomal RNA gene promotor and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element. Indicus|evm.model.CM009519.1.45 P0CB47 UBFL1_HUMAN 54.762 0.525641 0.198473 UBTFL1 - Upstream-binding factor 1-like protein 1 - Homo sapiens (Human) - UBTFL1 gene Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development. Indicus|evm.model.CM009519.1.48 Q5VT98 PRA20_HUMAN 50.649 0.415033 1.93263 PRAMEF20 - PRAME family member 20 - Homo sapiens (Human) - PRAMEF20 gene cytoplasm Indicus|evm.model.CM009519.1.49 P17480 UBF1_HUMAN 58.696 0.451852 0.530105 UBTF - Nucleolar transcription factor 1 - Homo sapiens (Human) - UBTF gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Indicus|evm.model.CM009519.1.50 P25977 UBF1_RAT 53.247 0.475 0.209424 Ubtf - Nucleolar transcription factor 1 - Rattus norvegicus (Rat) - Ubtf gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (By similarity). Indicus|evm.model.CM009519.1.51 A6NGJ6 TRI64_HUMAN 58.613 0.988864 1 TRIM64 - Tripartite motif-containing protein 64 - Homo sapiens (Human) - TRIM64 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Indicus|evm.model.CM009519.1.52 A6NCK2 TR43B_HUMAN 51.124 0.988827 0.401345 TRIM43B - Tripartite motif-containing protein 43B - Homo sapiens (Human) - TRIM43B gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Indicus|evm.model.CM009519.1.53 A6NI03 TR64B_HUMAN 51.163 0.589862 0.483296 TRIM64B - Putative tripartite motif-containing protein 64B - Homo sapiens (Human) - TRIM64B gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Indicus|evm.model.CM009519.1.54 Q96BQ3 TRI43_HUMAN 47.750 0.935407 0.93722 TRIM43 - Tripartite motif-containing protein 43 - Homo sapiens (Human) - TRIM43 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Indicus|evm.model.CM009519.1.55 P0CB48 UBFL6_HUMAN 65.306 0.60625 0.4 UBTFL6 - Putative upstream-binding factor 1-like protein 6 - Homo sapiens (Human) - UBTFL6 gene Indicus|evm.model.CM009519.1.56 A6NLI5 TR64C_HUMAN 59.152 0.982262 1.00222 TRIM64C - Tripartite motif-containing protein 64C - Homo sapiens (Human) - TRIM64C gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Indicus|evm.model.CM009519.1.57 A6NGJ6 TRI64_HUMAN 58.837 0.988914 1.00445 TRIM64 - Tripartite motif-containing protein 64 - Homo sapiens (Human) - TRIM64 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Indicus|evm.model.CM009519.1.58 O77564 FOLH1_PIG 92.543 0.997337 1 FOLH1 - Glutamate carboxypeptidase 2 - Sus scrofa (Pig) - FOLH1 gene Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Indicus|evm.model.CM009519.1.59 Q5R5C5 NOX4_PONAB 94.497 0.985019 0.923875 NOX4 - NADPH oxidase 4 - Pongo abelii (Sumatran orangutan) - NOX4 gene Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (By similarity). Indicus|evm.model.CM009519.1.60 Q8MIU0 TYRO_BOVIN 99.408 0.988235 0.320755 TYR - Tyrosinase precursor - Bos taurus (Bovine) - TYR gene This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity). Indicus|evm.model.CM009519.1.61 Q8MIU0 TYRO_BOVIN 99.710 0.971751 0.667925 TYR - Tyrosinase precursor - Bos taurus (Bovine) - TYR gene This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity). Indicus|evm.model.CM009519.1.62 P31424 GRM5_RAT 99.681 0.386617 0.670823 Grm5 - Metabotropic glutamate receptor 5 precursor - Rattus norvegicus (Rat) - Grm5 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. Indicus|evm.model.CM009519.1.63 P41594 GRM5_HUMAN 100.000 0.337349 0.136964 GRM5 - Metabotropic glutamate receptor 5 precursor - Homo sapiens (Human) - GRM5 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. Indicus|evm.model.CM009519.1.64 O19110 TSPY1_BOVIN 66.667 0.119497 1.00315 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009519.1.65 Q5R893 H2B1_PONAB 94.444 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009519.1.66 Q3ZCJ8 CATC_BOVIN 99.784 0.99569 1.00216 CTSC - Dipeptidyl peptidase 1 precursor - Bos taurus (Bovine) - CTSC gene Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function (By similarity). Indicus|evm.model.CM009519.1.67 Q8QZZ8 RAB38_MOUSE 95.735 0.990566 1.00474 Rab38 - Ras-related protein Rab-38 - Mus musculus (Mouse) - Rab38 gene Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (PubMed:21187289). Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560). Indicus|evm.model.CM009519.1.68 Q2HJ47 DENR_BOVIN 99.495 0.98995 1.00505 DENR - Density-regulated protein - Bos taurus (Bovine) - DENR gene May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity). Indicus|evm.model.CM009519.1.72 Q3T013 BNI3L_BOVIN 86.364 0.219388 0.894977 BNIP3L - BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like - Bos taurus (Bovine) - BNIP3L gene Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity). Indicus|evm.model.CM009519.1.73 Q3ZBE6 TM135_BOVIN 100.000 0.902516 0.694323 TMEM135 - Transmembrane protein 135 - Bos taurus (Bovine) - TMEM135 gene Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization. Indicus|evm.model.CM009519.1.74 Q9ULV1 FZD4_HUMAN 97.009 0.804217 1.2365 FZD4 - Frizzled-4 precursor - Homo sapiens (Human) - FZD4 gene Receptor for Wnt proteins (PubMed:30135577). Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (PubMed:30135577). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Indicus|evm.model.CM009519.1.75 Q1LZE9 PRS23_BOVIN 99.733 0.994681 1.00267 PRSS23 - Serine protease 23 precursor - Bos taurus (Bovine) - PRSS23 gene Indicus|evm.model.CM009519.1.76 Q16798 MAON_HUMAN 82.609 0.903955 0.879139 ME3 - NADP-dependent malic enzyme, mitochondrial precursor - Homo sapiens (Human) - ME3 gene mitochondrial matrix, mitochondrion, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, NADP+ binding, aerobic respiration, malate metabolic process, oxygen metabolic process, pyruvate metabolic process, tricarboxylic acid cycle Indicus|evm.model.CM009519.1.77 Q78EG7 TP4A1_RAT 88.439 0.988506 1.00578 Ptp4a1 - Protein tyrosine phosphatase type IVA 1 precursor - Rattus norvegicus (Rat) - Ptp4a1 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). Indicus|evm.model.CM009519.1.78 Q6ZN84 CCD81_HUMAN 79.542 0.996951 1.00613 CCDC81 - Coiled-coil domain-containing protein 81 - Homo sapiens (Human) - CCDC81 gene centrosome Indicus|evm.model.CM009519.1.79 Q56JY0 HIKES_BOVIN 100.000 0.989899 1.00508 HIKESHI - Protein Hikeshi - Bos taurus (Bovine) - HIKESHI gene Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity). Indicus|evm.model.CM009519.1.80 Q3SZ25 EED_BOVIN 100.000 0.995475 1.00227 EED - Polycomb protein EED - Bos taurus (Bovine) - EED gene Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Indicus|evm.model.CM009519.1.81 Q7M6Y3 PICAL_MOUSE 89.327 0.996429 0.848485 Picalm - Phosphatidylinositol-binding clathrin assembly protein - Mus musculus (Mouse) - Picalm gene Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF). Indicus|evm.model.CM009519.1.82 Q2TA00 CCD83_BOVIN 99.516 0.995169 1.00242 CCDC83 - Coiled-coil domain-containing protein 83 - Bos taurus (Bovine) - CCDC83 gene Indicus|evm.model.CM009519.1.83 A6QP06 SYTL2_BOVIN 99.576 0.997881 1.00106 SYTL2 - Synaptotagmin-like protein 2 - Bos taurus (Bovine) - SYTL2 gene May act as a RAB27A effector protein and play a role in cytotoxic granule exocytosis in lymphocytes. Indicus|evm.model.CM009519.1.84 Q29RS0 CCD89_BOVIN 99.730 0.994609 1.0027 CCDC89 - Coiled-coil domain-containing protein 89 - Bos taurus (Bovine) - CCDC89 gene Indicus|evm.model.CM009519.1.85 Q9NS37 ZHANG_HUMAN 90.000 0.983516 1.02825 CREBZF - CREB/ATF bZIP transcription factor - Homo sapiens (Human) - CREBZF gene Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. Indicus|evm.model.CM009519.1.86 Q32L86 T126A_BOVIN 100.000 0.478049 2.08122 TMEM126A - Transmembrane protein 126A - Bos taurus (Bovine) - TMEM126A gene mitochondrion, mitochondrial respiratory chain complex I assembly Indicus|evm.model.CM009519.1.88 Q9GZT6 CC90B_HUMAN 88.511 0.939759 0.980315 CCDC90B - Coiled-coil domain-containing protein 90B, mitochondrial precursor - Homo sapiens (Human) - CCDC90B gene mitochondrion Indicus|evm.model.CM009519.1.89 Q8N9B4 ANR42_HUMAN 82.456 0.765385 1.33676 ANKRD42 - Ankyrin repeat domain-containing protein 42 - Homo sapiens (Human) - ANKRD42 gene Indicus|evm.model.CM009519.1.90 O94913 PCF11_HUMAN 96.512 0.521581 1.05788 PCF11 - Pre-mRNA cleavage complex 2 protein Pcf11 - Homo sapiens (Human) - PCF11 gene Component of pre-mRNA cleavage complex II. Indicus|evm.model.CM009519.1.93 Q923S9 RAB30_MOUSE 100.000 0.990196 1.00493 Rab30 - Ras-related protein Rab-30 precursor - Mus musculus (Mouse) - Rab30 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (By similarity). Indicus|evm.model.CM009519.1.94 Q8IXT1 DDIAS_HUMAN 66.963 0.993994 1.001 DDIAS - DNA damage-induced apoptosis suppressor protein - Homo sapiens (Human) - DDIAS gene May be an anti-apoptotic protein involved in DNA repair or cell survival. Indicus|evm.model.CM009519.1.95 Q2TA14 PCP_BOVIN 98.597 0.996 1.002 PRCP - Lysosomal Pro-X carboxypeptidase precursor - Bos taurus (Bovine) - PRCP gene Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity). Indicus|evm.model.CM009519.1.96 A7MB34 F181B_BOVIN 99.522 0.684211 0.725537 FAM181B - Protein FAM181B - Bos taurus (Bovine) - FAM181B gene Indicus|evm.model.CM009519.1.97 Q6QN05 RL21_CHILA 86.250 0.975309 0.50625 RPL21 - 60S ribosomal protein L21 - Chinchilla lanigera (Long-tailed chinchilla) - RPL21 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009519.1.98 Q53H47 SETMR_HUMAN 53.425 0.994536 0.267544 SETMAR - Histone-lysine N-methyltransferase SETMAR - Homo sapiens (Human) - SETMAR gene Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). Indicus|evm.model.CM009519.1.100 Q3UHK6 TEN4_MOUSE 93.293 0.679167 0.0866113 Tenm4 - Teneurin-4 - Mus musculus (Mouse) - Tenm4 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer. Indicus|evm.model.CM009519.1.101 Q6N022 TEN4_HUMAN 96.419 0.99695 0.947273 TENM4 - Teneurin-4 - Homo sapiens (Human) - TENM4 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). Indicus|evm.model.CM009519.1.102 Q96I59 SYNM_HUMAN 92.994 0.385185 0.849057 NARS2 - Probable asparagine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - NARS2 gene cytosol, mitochondrion, nucleoplasm, asparagine-tRNA ligase activity, asparaginyl-tRNA aminoacylation Indicus|evm.model.CM009519.1.103 Q5NVM8 RNPS1_PONAB 75.000 0.329843 0.62623 RNPS1 - RNA-binding protein with serine-rich domain 1 - Pongo abelii (Sumatran orangutan) - RNPS1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity). Indicus|evm.model.CM009519.1.104 Q9UQC2 GAB2_HUMAN 92.500 0.99688 0.948225 GAB2 - GRB2-associated-binding protein 2 - Homo sapiens (Human) - GAB2 gene Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Indicus|evm.model.CM009519.1.105 Q9P2H5 UBP35_HUMAN 96.989 0.474923 0.959725 USP35 - Ubiquitin carboxyl-terminal hydrolase 35 - Homo sapiens (Human) - USP35 gene cytosol, nucleus, cysteine-type endopeptidase activity, thiol-dependent deubiquitinase, protein deubiquitination Indicus|evm.model.CM009519.1.106 Q4G0X4 KCD21_HUMAN 99.554 0.991111 0.865385 KCTD21 - BTB/POZ domain-containing protein KCTD21 - Homo sapiens (Human) - KCTD21 gene Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Indicus|evm.model.CM009519.1.107 Q0P5D9 ALG8_BOVIN 99.620 0.996205 1.0019 ALG8 - Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase - Bos taurus (Bovine) - ALG8 gene Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it is transferred to the nascent peptide (By similarity). Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia (By similarity). Indicus|evm.model.CM009519.1.108 Q02827 NDUC2_BOVIN 99.167 0.983471 1.00833 NDUFC2 - NADH dehydrogenase [ubiquinone] 1 subunit C2 - Bos taurus (Bovine) - NDUFC2 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009519.1.109 Q92748 THRSP_HUMAN 72.973 0.936306 1.07534 THRSP - Thyroid hormone-inducible hepatic protein - Homo sapiens (Human) - THRSP gene Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB. Indicus|evm.model.CM009519.1.110 Q9BQ13 KCD14_HUMAN 68.016 0.954918 0.956863 KCTD14 - BTB/POZ domain-containing protein KCTD14 - Homo sapiens (Human) - KCTD14 gene Indicus|evm.model.CM009519.1.111 Q96HW7 INT4_HUMAN 96.992 0.997927 1.00208 INTS4 - Integrator complex subunit 4 - Homo sapiens (Human) - INTS4 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Indicus|evm.model.CM009519.1.112 Q32PA8 AAMDC_BOVIN 73.770 0.978022 0.745902 AAMDC - Mth938 domain-containing protein - Bos taurus (Bovine) - AAMDC gene May play a role in preadipocyte differentiation and adipogenesis. Indicus|evm.model.CM009519.1.113 Q96T23 RSF1_HUMAN 90.273 0.99021 0.992366 RSF1 - Remodeling and spacing factor 1 - Homo sapiens (Human) - RSF1 gene Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598). Indicus|evm.model.CM009519.1.114 P35521 ICLN_CANLF 96.624 0.991597 1.01277 CLNS1A - Methylosome subunit pICln - Canis lupus familiaris (Dog) - CLNS1A gene Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway (By similarity). Indicus|evm.model.CM009519.1.115 F6S3G9 AQP11_HORSE 87.500 0.992647 1 AQP11 - Aquaporin-11 - Equus caballus (Horse) - AQP11 gene Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (By similarity). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development (By similarity). Indicus|evm.model.CM009519.1.116 Q08E52 PAK1_BOVIN 100.000 0.99633 1.00184 PAK1 - Serine/threonine-protein kinase PAK 1 - Bos taurus (Bovine) - PAK1 gene Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation. Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion. In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (By similarity). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (By similarity). Indicus|evm.model.CM009519.1.120 O46414 FRIH_BOVIN 96.923 0.969697 0.364641 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009519.1.122 Q86TE4 LUZP2_HUMAN 68.580 0.990798 0.942197 LUZP2 - Leucine zipper protein 2 precursor - Homo sapiens (Human) - LUZP2 gene Indicus|evm.model.CM009519.1.123 P00355 G3P_PIG 67.105 0.984314 0.765766 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Sus scrofa (Pig) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Indicus|evm.model.CM009519.1.124 H3BU77 CC179_HUMAN 65.217 0.849057 0.779412 CCDC179 - Coiled-coil domain-containing protein 179 - Homo sapiens (Human) - CCDC179 gene Indicus|evm.model.CM009519.1.125 O43903 GAS2_HUMAN 98.403 0.993631 1.00319 GAS2 - Growth arrest-specific protein 2 - Homo sapiens (Human) - GAS2 gene May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). Indicus|evm.model.CM009519.1.126 Q9NPI8 FANCF_HUMAN 74.790 0.988889 0.962567 FANCF - Fanconi anemia group F protein - Homo sapiens (Human) - FANCF gene DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity). Indicus|evm.model.CM009519.1.127 A6QLI1 VGLU2_BOVIN 92.955 0.99631 0.931271 SLC17A6 - Vesicular glutamate transporter 2 - Bos taurus (Bovine) - SLC17A6 gene Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity). May also mediate the transport of inorganic phosphate (By similarity). Involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). Indicus|evm.model.CM009519.1.128 Q75V66 ANO5_HUMAN 82.533 0.7979 1.25192 ANO5 - Anoctamin-5 - Homo sapiens (Human) - ANO5 gene Does not exhibit calcium-activated chloride channel (CaCC) activity. Indicus|evm.model.CM009519.1.129 Q92832 NELL1_HUMAN 90.086 0.762069 0.358025 NELL1 - Protein kinase C-binding protein NELL1 precursor - Homo sapiens (Human) - NELL1 gene Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. Indicus|evm.model.CM009519.1.131 Q9Y345 SC6A5_HUMAN 95.570 0.997472 0.992472 SLC6A5 - Sodium- and chloride-dependent glycine transporter 2 - Homo sapiens (Human) - SLC6A5 gene Sodium- and chloride-dependent glycine transporter (PubMed:9845349, PubMed:10381548, PubMed:10606742, PubMed:31370103). Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:9845349). May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (PubMed:9845349). Indicus|evm.model.CM009519.1.132 O60678 ANM3_HUMAN 83.051 0.995851 0.907721 PRMT3 - Protein arginine N-methyltransferase 3 - Homo sapiens (Human) - PRMT3 gene Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. Indicus|evm.model.CM009519.1.133 Q9BUP3 HTAI2_HUMAN 93.802 0.860714 1.15702 HTATIP2 - Oxidoreductase HTATIP2 - Homo sapiens (Human) - HTATIP2 gene Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. Indicus|evm.model.CM009519.1.134 Q67ER4 R113A_BOVIN 84.091 0.994318 1.02624 RNF113A - E3 ubiquitin-protein ligase RNF113A - Bos taurus (Bovine) - RNF113A gene Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. Indicus|evm.model.CM009519.1.135 A5PKG8 DBX1_BOVIN 100.000 0.99422 1.0029 DBX1 - Homeobox protein DBX1 - Bos taurus (Bovine) - DBX1 gene Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity). Indicus|evm.model.CM009519.1.137 E1BKK0 E2F8_BOVIN 99.295 0.997653 0.983834 E2F8 - Transcription factor E2F8 - Bos taurus (Bovine) - E2F8 gene Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene (By similarity). Indicus|evm.model.CM009519.1.138 Q4U0T9 CSRP3_BOVIN 100.000 0.989744 1.00515 CSRP3 - Cysteine and glycine-rich protein 3 - Bos taurus (Bovine) - CSRP3 gene Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association. In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). Indicus|evm.model.CM009519.1.139 Q4R690 ZDH13_MACFA 87.363 0.996885 1.03215 ZDHHC13 - Palmitoyltransferase ZDHHC13 - Macaca fascicularis (Crab-eating macaque) - ZDHHC13 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport. Indicus|evm.model.CM009519.1.140 Q4QXU2 MRGX2_RHIBE 60.790 0.923513 1.0697 MRGPRX2 - Mas-related G-protein coupled receptor member X2 - Rhinopithecus bieti (Black snub-nosed monkey) - MRGPRX2 gene Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Indicus|evm.model.CM009519.1.142 P35234 PTN5_RAT 94.278 0.350239 2.83198 Ptpn5 - Tyrosine-protein phosphatase non-receptor type 5 - Rattus norvegicus (Rat) - Ptpn5 gene May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. Indicus|evm.model.CM009519.1.144 Q3MHQ7 TM86A_BOVIN 97.490 0.979424 1.0125 TMEM86A - Lysoplasmalogenase-like protein TMEM86A - Bos taurus (Bovine) - TMEM86A gene alkenylglycerophosphocholine hydrolase activity, alkenylglycerophosphoethanolamine hydrolase activity Indicus|evm.model.CM009519.1.145 Q68D10 SPT2_HUMAN 83.584 0.966276 0.99562 SPTY2D1 - Protein SPT2 homolog - Homo sapiens (Human) - SPTY2D1 gene Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026). Indicus|evm.model.CM009519.1.146 Q8IX04 UEVLD_HUMAN 92.357 0.995763 1.00212 UEVLD - Ubiquitin-conjugating enzyme E2 variant 3 - Homo sapiens (Human) - UEVLD gene Possible negative regulator of polyubiquitination. Indicus|evm.model.CM009519.1.147 P04394 NDUV2_BOVIN 89.412 0.567568 0.594378 NDUFV2 - NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor - Bos taurus (Bovine) - NDUFV2 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Indicus|evm.model.CM009519.1.148 Q99816 TS101_HUMAN 97.442 0.994898 1.00513 TSG101 - Tumor susceptibility gene 101 protein - Homo sapiens (Human) - TSG101 gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). Indicus|evm.model.CM009519.1.150 Q9TSX5 LDHC_PIG 91.566 0.993994 1.00301 LDHC - L-lactate dehydrogenase C chain - Sus scrofa (Pig) - LDHC gene Possible role in sperm motility. Indicus|evm.model.CM009519.1.151 P19858 LDHA_BOVIN 100.000 0.914365 1.09036 LDHA - L-lactate dehydrogenase A chain - Bos taurus (Bovine) - LDHA gene L-lactate dehydrogenase activity Indicus|evm.model.CM009519.1.152 P32780 TF2H1_HUMAN 97.628 0.90264 1.10584 GTF2H1 - General transcription factor IIH subunit 1 - Homo sapiens (Human) - GTF2H1 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Indicus|evm.model.CM009519.1.153 Q9UPZ3 HPS5_HUMAN 87.965 0.998232 1.00177 HPS5 - Hermansky-Pudlak syndrome 5 protein - Homo sapiens (Human) - HPS5 gene May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. Indicus|evm.model.CM009519.1.154 P42819 SAA_SHEEP 83.036 0.840909 1.17857 SAA1 - Serum amyloid A protein - Ovis aries (Sheep) - SAA1 gene Major acute phase reactant. Apolipoprotein of the HDL complex. Indicus|evm.model.CM009519.1.155 P35541 SAA_BOVIN 98.462 0.921429 1.07692 SAA1 - Serum amyloid A protein precursor - Bos taurus (Bovine) - SAA1 gene Major acute phase reactant. Apolipoprotein of the HDL complex. Indicus|evm.model.CM009519.1.156 P35541 SAA_BOVIN 99.231 0.724719 1.36923 SAA1 - Serum amyloid A protein precursor - Bos taurus (Bovine) - SAA1 gene Major acute phase reactant. Apolipoprotein of the HDL complex. Indicus|evm.model.CM009519.1.157 Q3KNA1 MRGB2_MOUSE 67.500 0.428571 0.269231 Mrgprb2 - Mas-related G-protein coupled receptor member B2 - Mus musculus (Mouse) - Mrgprb2 gene Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (PubMed:25517090). Indicus|evm.model.CM009519.1.158 Q32L76 SAA4_BOVIN 99.225 0.984615 1.00775 SAA4 - Serum amyloid A-4 protein precursor - Bos taurus (Bovine) - SAA4 gene Major acute phase reactant. Indicus|evm.model.CM009519.1.159 P42819 SAA_SHEEP 84.685 0.833333 1.17857 SAA1 - Serum amyloid A protein - Ovis aries (Sheep) - SAA1 gene Major acute phase reactant. Apolipoprotein of the HDL complex. Indicus|evm.model.CM009519.1.160 Q8NGN1 OR6T1_HUMAN 64.925 0.741573 0.551084 OR6T1 - Olfactory receptor 6T1 - Homo sapiens (Human) - OR6T1 gene Odorant receptor. Indicus|evm.model.CM009519.1.161 Q8NH80 O10D3_HUMAN 76.316 0.425287 0.278846 OR10D3 - Putative olfactory receptor 10D3 - Homo sapiens (Human) - OR10D3 gene Odorant receptor. Indicus|evm.model.CM009519.1.163 Q8NH80 O10D3_HUMAN 63.934 0.967742 0.198718 OR10D3 - Putative olfactory receptor 10D3 - Homo sapiens (Human) - OR10D3 gene Odorant receptor. Indicus|evm.model.CM009519.1.164 O00534 VMA5A_HUMAN 70.581 0.996183 1 VWA5A - von Willebrand factor A domain-containing protein 5A - Homo sapiens (Human) - VWA5A gene May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. Indicus|evm.model.CM009519.1.165 O15481 MAGB4_HUMAN 55.776 0.287488 3.02601 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009519.1.168 Q6IF36 O8G2P_HUMAN 81.915 0.781513 0.391447 OR8G2P - Putative olfactory receptor 8G2 - Homo sapiens (Human) - OR8G2P gene Odorant receptor. Indicus|evm.model.CM009519.1.169 Q32KQ5 TM225_BOVIN 99.134 0.991379 1.00433 TMEM225 - Transmembrane protein 225 - Bos taurus (Bovine) - TMEM225 gene Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC. Indicus|evm.model.CM009519.1.171 Q6IF36 O8G2P_HUMAN 82.979 0.781513 0.391447 OR8G2P - Putative olfactory receptor 8G2 - Homo sapiens (Human) - OR8G2P gene Odorant receptor. Indicus|evm.model.CM009519.1.174 Q8NGG8 OR8B3_HUMAN 87.544 0.972222 0.920128 OR8B3 - Olfactory receptor 8B3 - Homo sapiens (Human) - OR8B3 gene Odorant receptor. Indicus|evm.model.CM009519.1.175 Q01105 SET_HUMAN 84.937 0.811644 1.0069 SET - Protein SET - Homo sapiens (Human) - SET gene Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Indicus|evm.model.CM009519.1.176 Q96RC9 OR8B4_HUMAN 83.495 0.993548 1.00324 OR8B4 - Olfactory receptor 8B4 - Homo sapiens (Human) - OR8B4 gene Odorant receptor. Indicus|evm.model.CM009519.1.177 Q60893 OL151_MOUSE 75.000 0.541985 0.423948 Olfr151 - Olfactory receptor 151 - Mus musculus (Mouse) - Olfr151 gene Odorant receptor. Indicus|evm.model.CM009519.1.178 Q96QZ0 PANX3_HUMAN 91.071 0.994911 1.00255 PANX3 - Pannexin-3 - Homo sapiens (Human) - PANX3 gene Structural component of the gap junctions and the hemichannels. Indicus|evm.model.CM009519.1.179 Q3YBR2 TBRG1_HUMAN 88.078 0.995146 1.00243 TBRG1 - Transforming growth factor beta regulator 1 - Homo sapiens (Human) - TBRG1 gene Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. Indicus|evm.model.CM009519.1.180 Q9HAT2 SIAE_HUMAN 77.438 0.996176 1 SIAE - Sialate O-acetylesterase precursor - Homo sapiens (Human) - SIAE gene Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. Indicus|evm.model.CM009519.1.181 Q62252 SP17_MOUSE 79.137 0.905405 0.993289 Spa17 - Sperm surface protein Sp17 - Mus musculus (Mouse) - Spa17 gene Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity). Indicus|evm.model.CM009519.1.182 P54877 NEUG_CAPHI 98.649 0.820225 1.14103 NRGN - Neurogranin - Capra hircus (Goat) - NRGN gene Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). Indicus|evm.model.CM009519.1.183 Q96IQ7 VSIG2_HUMAN 84.825 0.988372 0.788991 VSIG2 - V-set and immunoglobulin domain-containing protein 2 precursor - Homo sapiens (Human) - VSIG2 gene integral component of plasma membrane, membrane Indicus|evm.model.CM009519.1.184 Q96AP7 ESAM_HUMAN 76.010 0.994962 1.01795 ESAM - Endothelial cell-selective adhesion molecule precursor - Homo sapiens (Human) - ESAM gene Can mediate aggregation most likely through a homophilic molecular interaction. Indicus|evm.model.CM009519.1.185 Q6P1R3 MSD2_HUMAN 99.415 0.260736 1.16637 MSANTD2 - Myb/SANT-like DNA-binding domain-containing protein 2 - Homo sapiens (Human) - MSANTD2 gene Indicus|evm.model.CM009519.1.186 Q96MS0 ROBO3_HUMAN 88.905 0.998557 1 ROBO3 - Roundabout homolog 3 precursor - Homo sapiens (Human) - ROBO3 gene Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube (By similarity). In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing (PubMed:15105459). Indicus|evm.model.CM009519.1.187 Q8WZ75 ROBO4_HUMAN 84.082 0.974104 0.997021 ROBO4 - Roundabout homolog 4 precursor - Homo sapiens (Human) - ROBO4 gene Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). Indicus|evm.model.CM009519.1.188 A4FUY1 HECAM_BOVIN 88.723 0.995754 1.12679 HEPACAM - Hepatocyte cell adhesion molecule precursor - Bos taurus (Bovine) - HEPACAM gene Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (By similarity). Indicus|evm.model.CM009519.1.189 Q0P6D6 CCD15_HUMAN 59.879 0.613848 0.789695 CCDC15 - Coiled-coil domain-containing protein 15 - Homo sapiens (Human) - CCDC15 gene centrosome Indicus|evm.model.CM009519.1.190 Q58CV5 G6PT3_BOVIN 97.405 0.899281 1.13238 SLC37A2 - Glucose-6-phosphate exchanger SLC37A2 - Bos taurus (Bovine) - SLC37A2 gene Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. Indicus|evm.model.CM009519.1.191 A5PJF4 TM218_BOVIN 99.130 0.982759 1.0087 TMEM218 - Transmembrane protein 218 - Bos taurus (Bovine) - TMEM218 gene May be involved in ciliary biogenesis or function. Indicus|evm.model.CM009519.1.194 Q96KN3 PKNX2_HUMAN 98.478 0.995662 0.976695 PKNOX2 - Homeobox protein PKNOX2 - Homo sapiens (Human) - PKNOX2 gene intercellular bridge, nucleoplasm, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009519.1.195 Q99689 FEZ1_HUMAN 96.684 0.994911 1.00255 FEZ1 - Fasciculation and elongation protein zeta-1 - Homo sapiens (Human) - FEZ1 gene May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. Indicus|evm.model.CM009519.1.196 Q08DE5 EI24_BOVIN 99.412 0.994135 1.00294 EI24 - Etoposide-induced protein 2.4 homolog - Bos taurus (Bovine) - EI24 gene Indicus|evm.model.CM009519.1.197 Q2KJI2 STT3A_BOVIN 100.000 0.997167 1.00142 STT3A - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A - Bos taurus (Bovine) - STT3A gene Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A (By similarity). Indicus|evm.model.CM009519.1.199 O14757 CHK1_HUMAN 95.588 0.70059 1.42437 CHEK1 - Serine/threonine-protein kinase Chk1 - Homo sapiens (Human) - CHEK1 gene Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:9278511, PubMed:12676583, PubMed:14681206, PubMed:12676925, PubMed:12759351, PubMed:19734889, PubMed:14559997). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:9278511, PubMed:12676583, PubMed:14681206, PubMed:12676925, PubMed:12759351, PubMed:19734889). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:9278511, PubMed:19734889, PubMed:20090422). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). Indicus|evm.model.CM009519.1.200 P26436 ASPX_HUMAN 64.000 0.992701 1.03396 ACRV1 - Acrosomal protein SP-10 precursor - Homo sapiens (Human) - ACRV1 gene multicellular organism development Indicus|evm.model.CM009519.1.201 Q3SX07 PUS3_BOVIN 99.792 0.995851 1.00208 PUS3 - tRNA pseudouridine(38/39) synthase - Bos taurus (Bovine) - PUS3 gene Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. Indicus|evm.model.CM009519.1.202 Q2KI52 HYLS1_BOVIN 99.682 0.993651 1.00318 HYLS1 - Hydrolethalus syndrome protein 1 homolog - Bos taurus (Bovine) - HYLS1 gene Plays a role in ciliogenesis. Indicus|evm.model.CM009519.1.203 Q2TBP1 DDX25_BOVIN 99.793 0.995868 1.00207 DDX25 - ATP-dependent RNA helicase DDX25 - Bos taurus (Bovine) - DDX25 gene ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity). Indicus|evm.model.CM009519.1.204 P0DP72 VSXL2_HUMAN 76.923 0.918367 1.08605 VSIG10L2 - V-set and immunoglobulin domain-containing protein 10-like 2 precursor - Homo sapiens (Human) - VSIG10L2 gene cell-cell junction, integral component of plasma membrane, cell adhesion molecule binding, cell-cell adhesion Indicus|evm.model.CM009519.1.205 Q4KMG0 CDON_HUMAN 80.808 0.998397 0.969697 CDON - Cell adhesion molecule-related/down-regulated by oncogenes precursor - Homo sapiens (Human) - CDON gene Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). Indicus|evm.model.CM009519.1.206 Q5E9Z1 RUSD4_BOVIN 100.000 0.994709 1.00265 RPUSD4 - Mitochondrial RNA pseudouridine synthase RPUSD4 precursor - Bos taurus (Bovine) - RPUSD4 gene Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. Acts on position 39 in mitochondrial tRNA(Phe). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Indicus|evm.model.CM009519.1.207 Q5E977 F118B_BOVIN 97.414 0.871212 0.376068 FAM118B - Protein FAM118B - Bos taurus (Bovine) - FAM118B gene May play a role in Cajal bodies formation. Indicus|evm.model.CM009519.1.208 Q4R836 F118B_MACFA 100.000 0.262255 2.33143 FAM118B - Protein FAM118B - Macaca fascicularis (Crab-eating macaque) - FAM118B gene May play a role in Cajal bodies formation. Indicus|evm.model.CM009519.1.209 Q5EA45 FXRD1_BOVIN 100.000 0.995893 1.00206 FOXRED1 - FAD-dependent oxidoreductase domain-containing protein 1 - Bos taurus (Bovine) - FOXRED1 gene Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly. Indicus|evm.model.CM009519.1.210 P58753 TIRAP_HUMAN 77.056 0.987124 1.0543 TIRAP - Toll/interleukin-1 receptor domain-containing adapter protein - Homo sapiens (Human) - TIRAP gene Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. Indicus|evm.model.CM009519.1.211 O46415 FRIL_BOVIN 74.766 0.981481 0.617143 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009519.1.212 Q8MJJ7 DCPS_BOVIN 99.407 0.994083 1.00297 DCPS - m7GpppX diphosphatase - Bos taurus (Bovine) - DCPS gene Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death. Indicus|evm.model.CM009519.1.213 Q11206 SIA4C_HUMAN 89.189 0.994012 1.003 ST3GAL4 - CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 - Homo sapiens (Human) - ST3GAL4 gene A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8288606, PubMed:8611500). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8288606, PubMed:8611500). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (PubMed:8288606). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (PubMed:8611500). Indicus|evm.model.CM009519.1.214 Q8IZU9 KIRR3_HUMAN 98.419 0.997368 0.976864 KIRREL3 - Kin of IRRE-like protein 3 precursor - Homo sapiens (Human) - KIRREL3 gene Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells. Indicus|evm.model.CM009519.1.217 P41156 ETS1_RAT 98.551 0.849794 1.10204 Ets1 - Protein C-ets-1 - Rattus norvegicus (Rat) - Ets1 gene Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity). Indicus|evm.model.CM009519.1.219 Q29RS8 FLI1_BOVIN 99.329 0.95914 1.02876 FLI1 - Friend leukemia integration 1 transcription factor - Bos taurus (Bovine) - FLI1 gene Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3' (By similarity). Indicus|evm.model.CM009519.1.220 P48048 KCNJ1_HUMAN 95.430 0.994638 0.953964 KCNJ1 - ATP-sensitive inward rectifier potassium channel 1 - Homo sapiens (Human) - KCNJ1 gene In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. Indicus|evm.model.CM009519.1.221 F1MYR9 KCNJ5_BOVIN 100.000 0.995238 1.00239 KCNJ5 - G protein-activated inward rectifier potassium channel 4 - Bos taurus (Bovine) - KCNJ5 gene This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.Can be blocked by external barium. Indicus|evm.model.CM009519.1.223 Q5RFJ2 1433T_PONAB 95.510 0.991837 1 YWHAQ - 14-3-3 protein theta - Pongo abelii (Sumatran orangutan) - YWHAQ gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). Indicus|evm.model.CM009519.1.224 A7KAX9 RHG32_HUMAN 87.126 0.150174 0.963584 ARHGAP32 - Rho GTPase-activating protein 32 - Homo sapiens (Human) - ARHGAP32 gene GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). Indicus|evm.model.CM009519.1.226 Q9UMQ3 BARX2_HUMAN 100.000 0.579439 0.383513 BARX2 - Homeobox protein BarH-like 2 - Homo sapiens (Human) - BARX2 gene Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity). Indicus|evm.model.CM009519.1.227 Q9N0M2 BARX2_SHEEP 94.697 0.577093 1.70677 BARX2 - Homeobox protein BarH-like 2 - Ovis aries (Sheep) - BARX2 gene Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia. Indicus|evm.model.CM009519.1.228 P51813 BMX_HUMAN 75.000 0.425197 0.188148 BMX - Cytoplasmic tyrosine-protein kinase BMX - Homo sapiens (Human) - BMX gene Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. Indicus|evm.model.CM009519.1.229 Q9BX67 JAM3_HUMAN 84.839 0.875 1.10968 JAM3 - Junctional adhesion molecule C precursor - Homo sapiens (Human) - JAM3 gene Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:11590146, PubMed:11823489). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity). Indicus|evm.model.CM009519.1.230 Q9UPX0 TUTLB_HUMAN 95.212 0.882514 1.08525 IGSF9B - Protein turtle homolog B precursor - Homo sapiens (Human) - IGSF9B gene Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion. Indicus|evm.model.CM009519.1.231 Q3SZQ3 SPT19_BOVIN 100.000 0.987097 1.00649 SPATA19 - Spermatogenesis-associated protein 19, mitochondrial precursor - Bos taurus (Bovine) - SPATA19 gene May have a role in spermiogenesis. Indicus|evm.model.CM009519.1.236 P11834 OPCM_BOVIN 100.000 0.545455 0.286957 OPCML - Opioid-binding protein/cell adhesion molecule precursor - Bos taurus (Bovine) - OPCML gene Binds opioids in the presence of acidic lipids; probably involved in cell contact. Indicus|evm.model.CM009519.1.237 Q5IS61 OPCM_PANTR 100.000 0.554745 0.397101 OPCML - Opioid-binding protein/cell adhesion molecule precursor - Pan troglodytes (Chimpanzee) - OPCML gene Binds opioids in the presence of acidic lipids; probably involved in cell contact. Indicus|evm.model.CM009519.1.239 Q6WV90 H4_MYTGA 99.029 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Indicus|evm.model.CM009519.1.240 P11834 OPCM_BOVIN 100.000 0.909091 0.542029 OPCML - Opioid-binding protein/cell adhesion molecule precursor - Bos taurus (Bovine) - OPCML gene Binds opioids in the presence of acidic lipids; probably involved in cell contact. Indicus|evm.model.CM009519.1.241 Q58DA5 NTRI_BOVIN 93.750 0.99458 1.06957 NTM - Neurotrimin precursor - Bos taurus (Bovine) - NTM gene Neural cell adhesion molecule. Indicus|evm.model.CM009519.1.243 P51813 BMX_HUMAN 65.278 0.507246 0.204444 BMX - Cytoplasmic tyrosine-protein kinase BMX - Homo sapiens (Human) - BMX gene Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. Indicus|evm.model.CM009519.1.244 Q3T130 TM45B_BOVIN 99.638 0.99278 1.00362 TMEM45B - Transmembrane protein 45B - Bos taurus (Bovine) - TMEM45B gene Indicus|evm.model.CM009519.1.245 Q6P4R8 NFRKB_HUMAN 92.379 0.998452 0.994611 NFRKB - Nuclear factor related to kappa-B-binding protein - Homo sapiens (Human) - NFRKB gene Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. Indicus|evm.model.CM009519.1.246 Q9NQV6 PRD10_HUMAN 91.983 0.998262 1.00349 PRDM10 - PR domain zinc finger protein 10 - Homo sapiens (Human) - PRDM10 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009519.1.247 Q8NDX6 ZN740_HUMAN 98.446 0.989691 1.00518 ZNF740 - Zinc finger protein 740 - Homo sapiens (Human) - ZNF740 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009519.1.249 Q06335 APLP2_MOUSE 91.500 0.511905 1.06931 Aplp2 - Amyloid-like protein 2 precursor - Mus musculus (Mouse) - Aplp2 gene May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein (By similarity). Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts. Indicus|evm.model.CM009519.1.251 Q0IIH7 ST14_BOVIN 100.000 0.818182 0.167251 ST14 - Suppressor of tumorigenicity 14 protein homolog - Bos taurus (Bovine) - ST14 gene Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity). Indicus|evm.model.CM009519.1.252 Q0IIH7 ST14_BOVIN 87.619 0.978723 0.109942 ST14 - Suppressor of tumorigenicity 14 protein homolog - Bos taurus (Bovine) - ST14 gene Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity). Indicus|evm.model.CM009519.1.253 Q0IIH7 ST14_BOVIN 100.000 0.977733 0.577778 ST14 - Suppressor of tumorigenicity 14 protein homolog - Bos taurus (Bovine) - ST14 gene Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity). Indicus|evm.model.CM009519.1.254 Q8NCP5 ZBT44_HUMAN 96.991 0.915584 1.0807 ZBTB44 - Zinc finger and BTB domain-containing protein 44 - Homo sapiens (Human) - ZBTB44 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009519.1.255 Q9UP79 ATS8_HUMAN 75.666 0.944018 1.02475 ADAMTS8 - A disintegrin and metalloproteinase with thrombospondin motifs 8 precursor - Homo sapiens (Human) - ADAMTS8 gene Has anti-angiogenic properties. Indicus|evm.model.CM009519.1.256 Q8TE58 ATS15_HUMAN 91.579 0.997872 0.989474 ADAMTS15 - A disintegrin and metalloproteinase with thrombospondin motifs 15 precursor - Homo sapiens (Human) - ADAMTS15 gene Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration. Indicus|evm.model.CM009519.1.257 Q92543 SNX19_HUMAN 80.564 0.982018 1.00907 SNX19 - Sorting nexin-19 - Homo sapiens (Human) - SNX19 gene Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Indicus|evm.model.CM009519.1.258 Q9R1Z7 PTPS_MOUSE 92.188 0.76506 1.15278 Pts - 6-pyruvoyl tetrahydrobiopterin synthase - Mus musculus (Mouse) - Pts gene Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. Indicus|evm.model.CM009519.1.259 Q99N10 M4A8_MOUSE 61.753 0.991903 0.851724 Ms4a8 - Membrane-spanning 4-domains subfamily A member 8 - Mus musculus (Mouse) - Ms4a8 gene May be involved in signal transduction as a component of a multimeric receptor complex. Indicus|evm.model.CM009519.1.260 A6QPF4 M4A18_BOVIN 99.703 0.994083 1.00297 MS4A18 - Membrane-spanning 4-domains subfamily A member 18 - Bos taurus (Bovine) - MS4A18 gene Indicus|evm.model.CM009519.1.261 Q3UPL6 M4A15_MOUSE 89.520 0.938272 0.991837 Ms4a15 - Membrane-spanning 4-domains subfamily A member 15 - Mus musculus (Mouse) - Ms4a15 gene May be involved in signal transduction as a component of a multimeric receptor complex. Indicus|evm.model.CM009519.1.262 Q96PG2 M4A10_HUMAN 60.000 0.96748 0.921348 MS4A10 - Membrane-spanning 4-domains subfamily A member 10 - Homo sapiens (Human) - MS4A10 gene May be involved in signal transduction as a component of a multimeric receptor complex. Indicus|evm.model.CM009519.1.263 Q2TBX7 CCD86_BOVIN 99.718 0.994366 1.00282 CCDC86 - Coiled-coil domain-containing protein 86 - Bos taurus (Bovine) - CCDC86 gene Indicus|evm.model.CM009519.1.264 Q9Y5Y4 PD2R2_HUMAN 80.732 0.992629 1.03038 PTGDR2 - Prostaglandin D2 receptor 2 - Homo sapiens (Human) - PTGDR2 gene Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. Indicus|evm.model.CM009519.1.265 Q08E38 PRP19_BOVIN 100.000 0.99604 1.00198 PRPF19 - Pre-mRNA-processing factor 19 - Bos taurus (Bovine) - PRPF19 gene Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries. The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair. Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response. May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA. As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process. In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (By similarity). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity). Indicus|evm.model.CM009519.1.266 O77751 TM109_RABIT 85.185 0.991803 1.00412 TMEM109 - Transmembrane protein 109 precursor - Oryctolagus cuniculus (Rabbit) - TMEM109 gene May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (By similarity). Can form voltage-gated calcium and potassium channels in vitro (PubMed:21381722). Indicus|evm.model.CM009519.1.267 Q24JP5 T132A_HUMAN 89.796 0.998058 1.00684 TMEM132A - Transmembrane protein 132A precursor - Homo sapiens (Human) - TMEM132A gene May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity). Indicus|evm.model.CM009519.1.268 Q8IY34 S15A3_HUMAN 82.444 0.996564 1.00172 SLC15A3 - Solute carrier family 15 member 3 - Homo sapiens (Human) - SLC15A3 gene Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). Indicus|evm.model.CM009519.1.269 P30203 CD6_HUMAN 72.173 0.991137 1.01347 CD6 - T-cell differentiation antigen CD6 precursor - Homo sapiens (Human) - CD6 gene Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777). Indicus|evm.model.CM009519.1.270 P19238 CD5_BOVIN 99.394 0.995968 1.00202 CD5 - T-cell surface glycoprotein CD5 precursor - Bos taurus (Bovine) - CD5 gene May act as a receptor in regulating T-cell proliferation. Indicus|evm.model.CM009519.1.271 A5D8V6 VP37C_HUMAN 84.062 0.843915 1.06479 VPS37C - Vacuolar protein sorting-associated protein 37C - Homo sapiens (Human) - VPS37C gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Indicus|evm.model.CM009519.1.272 Q28755 PAG1_SHEEP 81.250 0.516667 0.157068 Pregnancy-associated glycoprotein 1 precursor - Ovis aries (Sheep) Indicus|evm.model.CM009519.1.273 Q29432 PAG1_BOVIN 75.455 0.923729 0.310526 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.274 Q29432 PAG1_BOVIN 82.044 0.99449 0.955263 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.275 Q29432 PAG1_BOVIN 77.955 0.996805 0.823684 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.276 Q29432 PAG1_BOVIN 81.768 0.99449 0.955263 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.277 P83495 PAG4_SHEEP 80.315 0.984375 0.336842 Pregnancy-associated glycoprotein 4 precursor - Ovis aries (Sheep) Indicus|evm.model.CM009519.1.278 Q29432 PAG1_BOVIN 80.663 0.99449 0.955263 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.279 Q29432 PAG1_BOVIN 80.511 0.996805 0.823684 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.281 Q29432 PAG1_BOVIN 100.000 0.99449 0.955263 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.282 Q29432 PAG1_BOVIN 81.470 0.996805 0.823684 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.283 Q29432 PAG1_BOVIN 82.748 0.996805 0.823684 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.284 Q29432 PAG1_BOVIN 66.382 0.990354 0.818421 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.285 Q29432 PAG1_BOVIN 78.594 0.996805 0.823684 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.286 P79110 TXTP_BOVIN 94.048 0.838384 0.318328 SLC25A1 - Tricarboxylate transport protein, mitochondrial precursor - Bos taurus (Bovine) - SLC25A1 gene Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Indicus|evm.model.CM009519.1.287 Q2KIV1 S22A9_BOVIN 100.000 0.991304 0.416667 SLC22A9 - Solute carrier family 22 member 9 - Bos taurus (Bovine) - SLC22A9 gene Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes (By similarity). Indicus|evm.model.CM009519.1.288 Q29432 PAG1_BOVIN 77.895 0.994737 1 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.289 Q2KIV1 S22A9_BOVIN 74.229 0.994575 1.00181 SLC22A9 - Solute carrier family 22 member 9 - Bos taurus (Bovine) - SLC22A9 gene Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes (By similarity). Indicus|evm.model.CM009519.1.290 Q4KLN5 PLAT5_RAT 91.139 0.928994 0.58885 Plaat5 - Phospholipase A and acyltransferase 5 - Rattus norvegicus (Rat) - Plaat5 gene Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:17158102). Indicus|evm.model.CM009519.1.291 Q29432 PAG1_BOVIN 80.889 0.991111 0.592105 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.292 P0DP31 CALM3_RAT 98.658 0.986667 1.00671 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Indicus|evm.model.CM009519.1.293 P00792 PEPA_BOVIN 98.910 0.963158 1.02151 PGA - Pepsin A precursor - Bos taurus (Bovine) - PGA gene Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. Indicus|evm.model.CM009519.1.294 Q96DN2 VWCE_HUMAN 77.429 0.99777 0.939267 VWCE - von Willebrand factor C and EGF domain-containing protein precursor - Homo sapiens (Human) - VWCE gene May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma. Indicus|evm.model.CM009519.1.295 A1A4K3 DDB1_BOVIN 99.563 0.998252 1.00351 DDB1 - DNA damage-binding protein 1 - Bos taurus (Bovine) - DDB1 gene Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (By similarity). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). Indicus|evm.model.CM009519.1.296 Q58DK4 TKFC_BOVIN 99.308 0.996546 1.00173 TKFC - Triokinase/FMN cyclase - Bos taurus (Bovine) - TKFC gene Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response. Indicus|evm.model.CM009519.1.297 A5D9A7 CYAC3_BOVIN 100.000 0.850909 1.03774 CYB561A3 - Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 - Bos taurus (Bovine) - CYB561A3 gene Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most problably involved in endosomal and lysosomal cellular iron homeostasis. Indicus|evm.model.CM009519.1.298 A5PJY4 TM138_BOVIN 100.000 0.436314 2.27778 TMEM138 - Transmembrane protein 138 - Bos taurus (Bovine) - TMEM138 gene Required for ciliogenesis. Indicus|evm.model.CM009519.1.299 Q8N684 CPSF7_HUMAN 99.788 0.886792 1.12527 CPSF7 - Cleavage and polyadenylation specificity factor subunit 7 - Homo sapiens (Human) - CPSF7 gene Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:8626397, PubMed:17024186, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:8626397, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:8626397, PubMed:17024186). Indicus|evm.model.CM009519.1.300 Q3ZBC2 SDHF2_BOVIN 100.000 0.988024 1.00602 SDHAF2 - Succinate dehydrogenase assembly factor 2, mitochondrial precursor - Bos taurus (Bovine) - SDHAF2 gene Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. Indicus|evm.model.CM009519.1.301 Q2T9T0 PPR32_BOVIN 99.533 0.995338 1.00234 PPP1R32 - Protein phosphatase 1 regulatory subunit 32 - Bos taurus (Bovine) - PPP1R32 gene phosphatase binding Indicus|evm.model.CM009519.1.302 A6NIK2 LR10B_HUMAN 96.233 0.993174 1.00342 LRRC10B - Leucine-rich repeat-containing protein 10B - Homo sapiens (Human) - LRRC10B gene Indicus|evm.model.CM009519.1.303 O43581 SYT7_HUMAN 95.157 0.465147 1.85112 SYT7 - Synaptotagmin-7 - Homo sapiens (Human) - SYT7 gene Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). Indicus|evm.model.CM009519.1.305 Q9Y4D2 DGLA_HUMAN 97.699 0.998081 1 DAGLA - Diacylglycerol lipase-alpha - Homo sapiens (Human) - DAGLA gene Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:26668358, PubMed:23502535). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). Indicus|evm.model.CM009519.1.306 Q9Y2G1 MYRF_HUMAN 91.637 0.988676 0.997394 MYRF - Myelin regulatory factor - Homo sapiens (Human) - MYRF gene Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). Indicus|evm.model.CM009519.1.307 Q32P84 TM258_BOVIN 100.000 0.973333 0.949367 TMEM258 - Transmembrane protein 258 - Bos taurus (Bovine) - TMEM258 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Involved in ER homeostasis in the colonic epithelium (By similarity). Indicus|evm.model.CM009519.1.308 Q58DH8 FEN1_BOVIN 100.000 0.994751 1.00263 FEN1 - Flap endonuclease 1 - Bos taurus (Bovine) - FEN1 gene Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. Indicus|evm.model.CM009519.1.309 O60427 FADS1_HUMAN 93.409 0.995465 0.993243 FADS1 - Acyl-CoA (8-3)-desaturase - Homo sapiens (Human) - FADS1 gene Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity). Indicus|evm.model.CM009519.1.310 Q5EA86 TM183_BOVIN 59.239 0.931973 0.390957 TMEM183 - Transmembrane protein 183 - Bos taurus (Bovine) - TMEM183 gene Indicus|evm.model.CM009519.1.311 A4FV48 FADS2_BOVIN 100.000 0.995506 1.00225 FADS2 - Acyl-CoA 6-desaturase - Bos taurus (Bovine) - FADS2 gene Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate, a metabolite in the biohydrogenation pathway of LA and the predominant trans fatty acid in cow milk) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity). Indicus|evm.model.CM009519.1.312 A4IFP3 FADS3_BOVIN 100.000 0.995495 1.00226 FADS3 - Fatty acid desaturase 3 - Bos taurus (Bovine) - FADS3 gene Mammals have different sphingoid bases that differ in their length and/or pattern of desaturation and hydroxyl groups. The predominant sphingoid base in mammalian ceramides is sphing-4-enine (sphingosine or SPH) which has a trans desaturation at carbon 4. FADS3 is a ceramide desaturase that introduces a cis double bond between carbon 14 and carbon 15 of the SPH-containing ceramides, producing sphinga-4,14-dienine-containing ceramides (SPD ceramides). SPD ceramides occur widely in mammalian tissues and cells. Due to their unusual structure containing a cis double bond, SPD ceramides may have an opposite, negative role in lipid microdomain formation relative to conventional ceramides (By similarity). FADS3 also acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in cow milk) at carbon 13 to generate (11E,13Z)-octadecadienoate (also known as conjugated linoleic acid 11E,13Z-CLA), likely participating in the biohydrogenation pathway of linoleic acid (LA) (By similarity). Indicus|evm.model.CM009519.1.313 Q2KJ58 R3GEF_BOVIN 100.000 0.878995 1.12308 RAB3IL1 - Guanine nucleotide exchange factor for Rab-3A - Bos taurus (Bovine) - RAB3IL1 gene Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B (By similarity). Indicus|evm.model.CM009519.1.314 Q8WMR7 BEST1_PIG 83.565 0.735495 1.36916 BEST1 - Bestrophin-1 - Sus scrofa (Pig) - BEST1 gene Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity). Indicus|evm.model.CM009519.1.315 O46414 FRIH_BOVIN 100.000 0.989011 1.00552 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009519.1.316 Q9NQS7 INCE_HUMAN 87.179 0.083878 1 INCENP - Inner centromere protein - Homo sapiens (Human) - INCENP gene Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). Indicus|evm.model.CM009519.1.317 A0JNP2 SG1D_BOVIN 100.000 0.980583 1.0098 SCGB1D - Secretoglobin family 1D member precursor - Bos taurus (Bovine) - SCGB1D gene May bind androgens and other steroids. May be under transcriptional regulation of steroid hormones (By similarity). Indicus|evm.model.CM009519.1.318 Q13296 SG2A2_HUMAN 46.250 0.76 1.07527 SCGB2A2 - Mammaglobin-A precursor - Homo sapiens (Human) - SCGB2A2 gene extracellular space, androgen receptor signaling pathway Indicus|evm.model.CM009519.1.320 Q32LE5 ASGL1_BOVIN 100.000 0.916418 1.08766 ASRGL1 - Isoaspartyl peptidase/L-asparaginase precursor - Bos taurus (Bovine) - ASRGL1 gene Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. Indicus|evm.model.CM009519.1.321 Q2VPS3 UTER_BOVIN 100.000 0.978261 1.01099 SCGB1A1 - Uteroglobin precursor - Bos taurus (Bovine) - SCGB1A1 gene Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Indicus|evm.model.CM009519.1.322 Q09666 AHNK_HUMAN 62.923 0.955725 0.778438 AHNAK - Neuroblast differentiation-associated protein AHNAK - Homo sapiens (Human) - AHNAK gene May be required for neuronal cell differentiation. Indicus|evm.model.CM009519.1.323 Q3SZV3 EF1G_BOVIN 99.773 0.995465 1.00227 EEF1G - Elongation factor 1-gamma - Bos taurus (Bovine) - EEF1G gene Probably plays a role in anchoring the complex to other cellular components. Indicus|evm.model.CM009519.1.324 Q1JPD6 STPAP_BOVIN 99.656 0.997706 1.00115 TUT1 - Speckle targeted PIP5K1A-regulated poly(A) polymerase - Bos taurus (Bovine) - TUT1 gene Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation. Indicus|evm.model.CM009519.1.325 Q9R190 MTA2_MOUSE 98.353 0.997001 0.998503 Mta2 - Metastasis-associated protein MTA2 - Mus musculus (Mouse) - Mta2 gene May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. Indicus|evm.model.CM009519.1.326 Q32P44 EMAL3_HUMAN 93.080 0.997768 1 EML3 - Echinoderm microtubule-associated protein-like 3 - Homo sapiens (Human) - EML3 gene Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). Indicus|evm.model.CM009519.1.327 P52205 ROM1_BOVIN 100.000 0.994318 1.00285 ROM1 - Rod outer segment membrane protein 1 - Bos taurus (Bovine) - ROM1 gene Plays a role in rod outer segment (ROS) morphogenesis (By similarity). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (PubMed:24196967). Plays a role in the organization of the ROS and maintenance of ROS disk diameter (By similarity). Involved in the maintenance of the retina outer nuclear layer (By similarity). Indicus|evm.model.CM009519.1.328 Q9WU47 B3GA3_CRIGR 95.821 0.994048 1.00299 B3GAT3 - Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 - Cricetulus griseus (Chinese hamster) - B3GAT3 gene Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Highest activity seen with Gal-beta-1,3-Gal-beta-O-R (where R=naphthalenemethanol or benzyl alcohol). Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation. Indicus|evm.model.CM009519.1.329 P79403 GANAB_PIG 93.340 0.984127 1.00106 GANAB - Neutral alpha-glucosidase AB precursor - Sus scrofa (Pig) - GANAB gene Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia. Indicus|evm.model.CM009519.1.330 Q6P9B9 INT5_HUMAN 96.663 0.998037 1 INTS5 - Integrator complex subunit 5 - Homo sapiens (Human) - INTS5 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Indicus|evm.model.CM009519.1.331 E9PRG8 CK098_HUMAN 88.618 0.983871 1.00813 C11orf98 - Uncharacterized protein C11orf98 - Homo sapiens (Human) - C11orf98 gene Indicus|evm.model.CM009519.1.332 A8MUP2 CSKMT_HUMAN 84.519 0.987552 1.00417 CSKMT - Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial precursor - Homo sapiens (Human) - CSKMT gene Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria (PubMed:28391595, PubMed:28887308). Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methly group per binding event (PubMed:28887308). Indicus|evm.model.CM009519.1.333 Q9BQE6 LBHD1_HUMAN 65.278 0.968326 0.764706 LBHD1 - LBH domain-containing protein 1 - Homo sapiens (Human) - LBHD1 gene nucleus, positive regulation of transcription, DNA-templated Indicus|evm.model.CM009519.1.334 Q148G8 UQCC3_BOVIN 96.629 0.778761 1.18947 UQCC3 - Ubiquinol-cytochrome-c reductase complex assembly factor 3 - Bos taurus (Bovine) - UQCC3 gene Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. Indicus|evm.model.CM009519.1.335 Q32KW2 UBXN1_BOVIN 100.000 0.993289 1.00337 UBXN1 - UBX domain-containing protein 1 - Bos taurus (Bovine) - UBXN1 gene Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity). Indicus|evm.model.CM009519.1.336 Q3SWY4 LRN4L_BOVIN 100.000 0.991416 1.00431 LRRN4CL - LRRN4 C-terminal-like protein precursor - Bos taurus (Bovine) - LRRN4CL gene Indicus|evm.model.CM009519.1.337 Q5E9P6 BSCL2_BOVIN 99.242 0.856833 1.17005 BSCL2 - Seipin - Bos taurus (Bovine) - BSCL2 gene Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). In association with TMEM159/LDAF1, defines the sites of LD formation in the ER (By similarity). Also required for growth and maturation of small nascent LDs into larger mature LDs (By similarity). Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (By similarity). Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (By similarity). Binds anionic phospholipids including phosphatidic acid (By similarity). Plays an important role in the differentiation and development of adipocytes (By similarity). Indicus|evm.model.CM009519.1.338 P63216 GBG3_MOUSE 100.000 0.973684 1.01333 Gng3 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 precursor - Mus musculus (Mouse) - Gng3 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Indicus|evm.model.CM009519.1.339 Q1KMD3 HNRL2_HUMAN 97.063 0.997333 1.00402 HNRNPUL2 - Heterogeneous nuclear ribonucleoprotein U-like protein 2 - Homo sapiens (Human) - HNRNPUL2 gene membrane, nucleoplasm, nucleus, RNA binding Indicus|evm.model.CM009519.1.340 A4IFF3 TTC9C_BOVIN 100.000 0.988372 1.00585 TTC9C - Tetratricopeptide repeat protein 9C - Bos taurus (Bovine) - TTC9C gene Indicus|evm.model.CM009519.1.341 Q9H5J0 ZBTB3_HUMAN 86.973 0.996109 0.89547 ZBTB3 - Zinc finger and BTB domain-containing protein 3 - Homo sapiens (Human) - ZBTB3 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009519.1.342 P62489 RPB7_RAT 100.000 0.988439 1.00581 Polr2g - DNA-directed RNA polymerase II subunit RPB7 - Rattus norvegicus (Rat) - Polr2g gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA (By similarity). Indicus|evm.model.CM009519.1.343 Q9Y6J9 TAF6L_HUMAN 93.730 0.985646 1.00804 TAF6L - TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L - Homo sapiens (Human) - TAF6L gene Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity). Indicus|evm.model.CM009519.1.344 Q7Z7N9 T179B_HUMAN 84.932 0.990868 1 TMEM179B - Transmembrane protein 179B - Homo sapiens (Human) - TMEM179B gene azurophil granule membrane, ficolin-1-rich granule membrane, nuclear speck, nucleolus, plasma membrane, secretory granule membrane, neutrophil degranulation Indicus|evm.model.CM009519.1.345 A5PJW2 TM223_BOVIN 100.000 0.990148 1.00495 TMEM223 - Transmembrane protein 223 - Bos taurus (Bovine) - TMEM223 gene nervous system development Indicus|evm.model.CM009519.1.346 Q1RMS5 NXF1_BOVIN 100.000 0.996779 1.00161 NXF1 - Nuclear RNA export factor 1 - Bos taurus (Bovine) - NXF1 gene Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Indicus|evm.model.CM009519.1.347 Q08DB5 STX5_BOVIN 100.000 0.994382 1.00282 STX5 - Syntaxin-5 - Bos taurus (Bovine) - STX5 gene Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Indicus|evm.model.CM009519.1.348 Q58D06 WDR74_BOVIN 91.003 0.680702 1.48052 WDR74 - WD repeat-containing protein 74 - Bos taurus (Bovine) - WDR74 gene Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. Indicus|evm.model.CM009519.1.349 P08195 4F2_HUMAN 78.731 0.933682 0.909524 SLC3A2 - 4F2 cell-surface antigen heavy chain - Homo sapiens (Human) - SLC3A2 gene Component of several heterodimeric complexes involved in amino acid transport (PubMed:11557028, PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:30341327). The precise substrate specificity depends on the other subunit in the heterodimer (PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:30867591, PubMed:10903140). The complexes function as amino acid exchangers (PubMed:11557028, PubMed:10903140, PubMed:12117417, PubMed:12225859, PubMed:30867591). The homodimer functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:11557028, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). The heterodimer formed by SLC3A2 and SLC7A6 or SLC3A2 and SLC7A7 mediates the uptake of dibasic amino acids (PubMed:9829974, PubMed:10903140). The heterodimer with SLC7A5/LAT1 mediates the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). The heterodimer with SLC7A5/LAT1 is involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). The heterodimer with SLC7A5/LAT1 is involved in the uptake of leucine (PubMed:25998567, PubMed:30341327). When associated with LAPTM4B, the heterodimer with SLC7A5/LAT1 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). The heterodimer formed by SLC3A2 and SLC7A5/LAT1 or SLC3A2 and SLC7A8/LAT2 is involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). Together with ICAM1, regulates the transport activity of SLC7A8/LAT2 in polarized intestinal cells by generating and delivering intracellular signals (PubMed:12716892). Required for targeting of SLC7A5/LAT1 and SLC7A8/LAT2 to the plasma membrane and for channel activity (PubMed:9751058, PubMed:11311135, PubMed:30867591). Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine (PubMed:14603368). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Indicus|evm.model.CM009519.1.350 P04761 ACM1_PIG 92.826 0.995349 0.934783 CHRM1 - Muscarinic acetylcholine receptor M1 - Sus scrofa (Pig) - CHRM1 gene The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Indicus|evm.model.CM009519.1.351 Q864Z3 S22A6_BOVIN 63.838 0.988909 0.985428 SLC22A6 - Solute carrier family 22 member 6 - Bos taurus (Bovine) - SLC22A6 gene Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of p-aminohippurate (PAH), 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate (By similarity). Indicus|evm.model.CM009519.1.352 Q864Z3 S22A6_BOVIN 99.636 0.996364 1.00182 SLC22A6 - Solute carrier family 22 member 6 - Bos taurus (Bovine) - SLC22A6 gene Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of p-aminohippurate (PAH), 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate (By similarity). Indicus|evm.model.CM009519.1.353 Q70BM6 S22A8_PIG 85.267 0.996324 1.00184 SLC22A8 - Solute carrier family 22 member 8 - Sus scrofa (Pig) - SLC22A8 gene Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Indicus|evm.model.CM009519.1.354 Q63ZE4 S22AA_HUMAN 52.847 0.995816 0.883549 SLC22A10 - Solute carrier family 22 member 10 - Homo sapiens (Human) - SLC22A10 gene organic anion transport Indicus|evm.model.CM009519.1.355 Q63ZE4 S22AA_HUMAN 66.355 0.965642 1.02218 SLC22A10 - Solute carrier family 22 member 10 - Homo sapiens (Human) - SLC22A10 gene organic anion transport Indicus|evm.model.CM009519.1.356 Q63ZE4 S22AA_HUMAN 68.105 0.996255 0.987061 SLC22A10 - Solute carrier family 22 member 10 - Homo sapiens (Human) - SLC22A10 gene organic anion transport Indicus|evm.model.CM009519.1.357 Q63ZE4 S22AA_HUMAN 67.850 0.923875 1.06839 SLC22A10 - Solute carrier family 22 member 10 - Homo sapiens (Human) - SLC22A10 gene organic anion transport Indicus|evm.model.CM009519.1.358 Q63ZE4 S22AA_HUMAN 65.121 0.972578 1.01109 SLC22A10 - Solute carrier family 22 member 10 - Homo sapiens (Human) - SLC22A10 gene organic anion transport Indicus|evm.model.CM009519.1.359 Q2KIV1 S22A9_BOVIN 97.561 0.506977 1.16848 SLC22A9 - Solute carrier family 22 member 9 - Bos taurus (Bovine) - SLC22A9 gene Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes (By similarity). Indicus|evm.model.CM009519.1.360 Q96DT0 LEG12_HUMAN 85.942 0.990476 0.9375 LGALS12 - Galectin-12 - Homo sapiens (Human) - LGALS12 gene Binds lactose. May participate in the apoptosis of adipocytes. Indicus|evm.model.CM009519.1.361 Q5R611 PLAT3_PONAB 66.250 0.88764 0.549383 PLAAT3 - Phospholipase A and acyltransferase 3 - Pongo abelii (Sumatran orangutan) - PLAAT3 gene Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (By similarity). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (By similarity). Indicus|evm.model.CM009519.1.362 P53816 PLAT3_HUMAN 74.522 0.96875 0.987654 PLAAT3 - Phospholipase A and acyltransferase 3 - Homo sapiens (Human) - PLAAT3 gene Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852). Indicus|evm.model.CM009519.1.363 Q8R3U1 PLAT3_MOUSE 65.741 0.890756 0.734568 Plaat3 - Phospholipase A and acyltransferase 3 - Mus musculus (Mouse) - Plaat3 gene Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19047760). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:18614531, PubMed:19047760, PubMed:19136964, PubMed:22134920). For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity,catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19047760). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (By similarity). Indicus|evm.model.CM009519.1.364 P53816 PLAT3_HUMAN 83.333 0.98773 1.00617 PLAAT3 - Phospholipase A and acyltransferase 3 - Homo sapiens (Human) - PLAAT3 gene Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852). Indicus|evm.model.CM009519.1.365 Q6DD88 ATLA3_HUMAN 94.270 0.99631 1.00185 ATL3 - Atlastin-3 - Homo sapiens (Human) - ATL3 gene GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977). Indicus|evm.model.CM009519.1.366 O95197 RTN3_HUMAN 68.428 0.996068 0.739341 RTN3 - Reticulon-3 - Homo sapiens (Human) - RTN3 gene May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Indicus|evm.model.CM009519.1.367 Q08D83 RTN3_BOVIN 99.145 0.60733 0.746094 RTN3 - Reticulon-3 - Bos taurus (Bovine) - RTN3 gene May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (By similarity). Indicus|evm.model.CM009519.1.368 Q08D83 RTN3_BOVIN 100.000 0.062963 2.10938 RTN3 - Reticulon-3 - Bos taurus (Bovine) - RTN3 gene May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (By similarity). Indicus|evm.model.CM009519.1.369 Q9BUA3 SPNDC_HUMAN 81.039 0.994737 0.997375 SPINDOC - Spindlin interactor and repressor of chromatin-binding protein - Homo sapiens (Human) - SPINDOC gene Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846). Indicus|evm.model.CM009519.1.371 Q7KZI7 MARK2_HUMAN 98.223 0.997459 0.998731 MARK2 - Serine/threonine-protein kinase MARK2 - Homo sapiens (Human) - MARK2 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Indicus|evm.model.CM009519.1.372 Q8IZ40 RCOR2_HUMAN 97.706 0.996183 1.00191 RCOR2 - REST corepressor 2 - Homo sapiens (Human) - RCOR2 gene May act as a component of a corepressor complex that represses transcription. Indicus|evm.model.CM009519.1.373 B2RYG6 OTUB1_RAT 99.262 0.992647 1.00369 Otub1 - Ubiquitin thioesterase OTUB1 - Rattus norvegicus (Rat) - Otub1 gene Hydrolase that can specifically remove compared to 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (By similarity). Indicus|evm.model.CM009519.1.374 Q2KHU5 MACD1_BOVIN 100.000 0.958457 1.03692 MACROD1 - ADP-ribose glycohydrolase MACROD1 - Bos taurus (Bovine) - MACROD1 gene Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. Indicus|evm.model.CM009519.1.376 Q3ZBZ8 STIP1_BOVIN 100.000 0.903333 1.10497 STIP1 - Stress-induced-phosphoprotein 1 - Bos taurus (Bovine) - STIP1 gene Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Indicus|evm.model.CM009519.1.377 Q32LP0 URP2_BOVIN 100.000 0.913486 0.590977 FERMT3 - Fermitin family homolog 3 - Bos taurus (Bovine) - FERMT3 gene Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Indicus|evm.model.CM009519.1.378 Q9D844 DNJC4_MOUSE 77.128 0.792373 0.967213 Dnajc4 - DnaJ homolog subfamily C member 4 - Mus musculus (Mouse) - Dnajc4 gene mitochondrion Indicus|evm.model.CM009519.1.379 Q2TBI8 NUD22_BOVIN 100.000 0.969799 1.02759 NUDT22 - Uridine diphosphate glucose pyrophosphatase NUDT22 - Bos taurus (Bovine) - NUDT22 gene Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose. Indicus|evm.model.CM009519.1.380 Q3ZBM7 TRPT1_BOVIN 99.606 0.881533 1.12992 TRPT1 - tRNA 2'-phosphotransferase 1 - Bos taurus (Bovine) - TRPT1 gene Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. Indicus|evm.model.CM009519.1.381 Q32LP0 URP2_BOVIN 96.057 0.929766 0.449624 FERMT3 - Fermitin family homolog 3 - Bos taurus (Bovine) - FERMT3 gene Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Indicus|evm.model.CM009519.1.382 Q9XS49 VEGFB_BOVIN 85.714 0.664894 0.908213 VEGFB - Vascular endothelial growth factor B precursor - Bos taurus (Bovine) - VEGFB gene Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis (By similarity). Indicus|evm.model.CM009519.1.383 Q32PA9 FKBP2_BOVIN 100.000 0.852761 1.16429 FKBP2 - Peptidyl-prolyl cis-trans isomerase FKBP2 precursor - Bos taurus (Bovine) - FKBP2 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Indicus|evm.model.CM009519.1.384 Q8MIK9 PP14B_PIG 100.000 0.7625 0.544218 PPP1R14B - Protein phosphatase 1 regulatory subunit 14B - Sus scrofa (Pig) - PPP1R14B gene Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). Indicus|evm.model.CM009519.1.385 Q01970 PLCB3_HUMAN 92.488 0.998381 1.00081 PLCB3 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 - Homo sapiens (Human) - PLCB3 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Indicus|evm.model.CM009519.1.386 Q92934 BAD_HUMAN 78.107 0.988166 1.00595 BAD - Bcl2-associated agonist of cell death - Homo sapiens (Human) - BAD gene Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. Indicus|evm.model.CM009519.1.387 Q17QQ5 G137A_BOVIN 100.000 0.994949 1.00253 GPR137 - Integral membrane protein GPR137 - Bos taurus (Bovine) - GPR137 gene Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. Indicus|evm.model.CM009519.1.388 Q9NYG8 KCNK4_HUMAN 88.089 0.992593 1.03053 KCNK4 - Potassium channel subfamily K member 4 - Homo sapiens (Human) - KCNK4 gene Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157, PubMed:30290154). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity). Indicus|evm.model.CM009519.1.389 Q9NTU4 CTSRZ_HUMAN 54.067 0.97561 1.025 CATSPERZ - Cation channel sperm-associated protein subunit zeta - Homo sapiens (Human) - CATSPERZ gene Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel. Indicus|evm.model.CM009519.1.390 P11474 ERR1_HUMAN 99.527 0.864476 1.1513 ESRRA - Steroid hormone receptor ERR1 - Homo sapiens (Human) - ESRRA gene Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. Indicus|evm.model.CM009519.1.391 Q2KIA2 TR112_BOVIN 100.000 0.659574 1.504 TRMT112 - Multifunctional methyltransferase subunit TRM112-like protein - Bos taurus (Bovine) - TRMT112 gene Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production. Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA. Indicus|evm.model.CM009519.1.392 Q9BGI1 PRDX5_BOVIN 100.000 0.990909 1.00457 PRDX5 - Peroxiredoxin-5, mitochondrial precursor - Bos taurus (Bovine) - PRDX5 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Indicus|evm.model.CM009519.1.393 O75676 KS6A4_HUMAN 95.894 0.342428 2.84845 RPS6KA4 - Ribosomal protein S6 kinase alpha-4 - Homo sapiens (Human) - RPS6KA4 gene Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Indicus|evm.model.CM009519.1.395 Q9NSA0 S22AB_HUMAN 66.062 0.992714 0.998182 SLC22A11 - Solute carrier family 22 member 11 - Homo sapiens (Human) - SLC22A11 gene Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds. Indicus|evm.model.CM009519.1.396 Q96S37 S22AC_HUMAN 60.561 0.995595 0.820976 SLC22A12 - Solute carrier family 22 member 12 - Homo sapiens (Human) - SLC22A12 gene Major urate transporter involved in renal reabsorption of urate and helps to maintain blood levels of uric acid (PubMed:12024214, PubMed:22194875). Translocates urate over the apical membrane of proximal tubular cells in exchange for organic anions or chloride ions (PubMed:12024214, PubMed:22194875). Indicus|evm.model.CM009519.1.397 Q9P2S2 NRX2A_HUMAN 95.093 0.998821 0.990654 NRXN2 - Neurexin-2 precursor - Homo sapiens (Human) - NRXN2 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Indicus|evm.model.CM009519.1.398 A6N9I4 GRP2_BOVIN 98.214 0.996759 1.0148 RASGRP2 - RAS guanyl-releasing protein 2 - Bos taurus (Bovine) - RASGRP2 gene Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. Indicus|evm.model.CM009519.1.399 P79334 PYGM_BOVIN 99.881 0.997628 1.00119 PYGM - Glycogen phosphorylase, muscle form - Bos taurus (Bovine) - PYGM gene Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Indicus|evm.model.CM009519.1.400 Q15637 SF01_HUMAN 99.622 0.961749 0.859155 SF1 - Splicing factor 1 - Homo sapiens (Human) - SF1 gene Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. Indicus|evm.model.CM009519.1.403 Q0P5I0 MEN1_BOVIN 100.000 0.420043 2.30656 MEN1 - Menin - Bos taurus (Bovine) - MEN1 gene Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair (By similarity). Indicus|evm.model.CM009519.1.404 Q6DT37 MRCKG_HUMAN 87.452 0.998705 0.995487 CDC42BPG - Serine/threonine-protein kinase MRCK gamma - Homo sapiens (Human) - CDC42BPG gene May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). Indicus|evm.model.CM009519.1.405 Q5E9R3 EHD1_BOVIN 100.000 0.989189 0.692884 EHD1 - EH domain-containing protein 1 - Bos taurus (Bovine) - EHD1 gene ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis. Indicus|evm.model.CM009519.1.406 Q2TAZ0 ATG2A_HUMAN 88.171 0.984298 0.5258 ATG2A - Autophagy-related protein 2 homolog A - Homo sapiens (Human) - ATG2A gene Involved in autophagosome assembly, regulating the size of nascent autophagosomes (PubMed:28561066). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (By similarity). Indicus|evm.model.CM009519.1.407 Q5E9R3 EHD1_BOVIN 100.000 0.762557 0.410112 EHD1 - EH domain-containing protein 1 - Bos taurus (Bovine) - EHD1 gene ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis. Indicus|evm.model.CM009519.1.408 Q2TAZ0 ATG2A_HUMAN 83.591 0.969849 0.513416 ATG2A - Autophagy-related protein 2 homolog A - Homo sapiens (Human) - ATG2A gene Involved in autophagosome assembly, regulating the size of nascent autophagosomes (PubMed:28561066). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (By similarity). Indicus|evm.model.CM009519.1.409 Q15173 2A5B_HUMAN 98.994 0.995976 1 PPP2R5B - Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform - Homo sapiens (Human) - PPP2R5B gene As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. Indicus|evm.model.CM009519.1.410 Q3KP22 MAJIN_HUMAN 93.878 0.123711 2.20455 MAJIN - Membrane-anchored junction protein - Homo sapiens (Human) - MAJIN gene Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. Indicus|evm.model.CM009519.1.411 Q8N1L9 BATF2_HUMAN 70.182 0.992754 1.0073 BATF2 - Basic leucine zipper transcriptional factor ATF-like 2 - Homo sapiens (Human) - BATF2 gene AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter. Indicus|evm.model.CM009519.1.412 Q2TA37 ARL2_BOVIN 100.000 0.989189 1.00543 ARL2 - ADP-ribosylation factor-like protein 2 - Bos taurus (Bovine) - ARL2 gene Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Indicus|evm.model.CM009519.1.413 Q148E7 SNX15_BOVIN 100.000 0.99422 1.0029 SNX15 - Sorting nexin-15 - Bos taurus (Bovine) - SNX15 gene May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity). Indicus|evm.model.CM009519.1.414 A6NKF1 SAC31_HUMAN 82.865 0.988858 0.888614 SAC3D1 - SAC3 domain-containing protein 1 - Homo sapiens (Human) - SAC3D1 gene Involved in centrosome duplication and mitotic progression. Indicus|evm.model.CM009519.1.415 Q9UQQ1 NALDL_HUMAN 82.550 0.997315 1.00676 NAALADL1 - Aminopeptidase NAALADL1 - Homo sapiens (Human) - NAALADL1 gene Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position (PubMed:25752612). Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity (PubMed:25752612). Indicus|evm.model.CM009519.1.416 Q96FF9 CDCA5_HUMAN 68.085 0.484472 1.91667 CDCA5 - Sororin - Homo sapiens (Human) - CDCA5 gene Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. Indicus|evm.model.CM009519.1.417 Q2YDD3 ZFPL1_BOVIN 92.857 0.993808 1.03526 ZFPL1 - Zinc finger protein-like 1 - Bos taurus (Bovine) - ZFPL1 gene Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130 (By similarity). Indicus|evm.model.CM009519.1.418 E9PQX1 TM262_HUMAN 78.070 0.949153 1.01724 TMEM262 - Transmembrane protein 262 - Homo sapiens (Human) - TMEM262 gene Indicus|evm.model.CM009519.1.419 A6QQ47 VPS51_BOVIN 100.000 0.552518 0.889885 VPS51 - Vacuolar protein sorting-associated protein 51 homolog - Bos taurus (Bovine) - VPS51 gene Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Indicus|evm.model.CM009519.1.420 Q8WMV1 ERG24_BOVIN 99.522 0.995227 1.00239 TM7SF2 - Delta(14)-sterol reductase TM7SF2 - Bos taurus (Bovine) - TM7SF2 gene Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Indicus|evm.model.CM009519.1.421 Q2TBW5 ZNHI2_BOVIN 99.749 0.995 1.00251 ZNHIT2 - Zinc finger HIT domain-containing protein 2 - Bos taurus (Bovine) - ZNHIT2 gene May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (By similarity). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (By similarity). May play a role in regulating the composition of the U5 snRNP complex (By similarity). Indicus|evm.model.CM009519.1.422 P62864 RS30_RAT 100.000 0.623656 1.57627 Fau - 40S ribosomal protein S30 - Rattus norvegicus (Rat) - Fau gene antimicrobial humoral immune response mediated by antimicrobial peptide, defense response to Gram-positive bacterium Indicus|evm.model.CM009519.1.423 Q5EA71 RM49_BOVIN 100.000 0.988024 1.00602 MRPL49 - 39S ribosomal protein L49, mitochondrial - Bos taurus (Bovine) - MRPL49 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, structural constituent of ribosome Indicus|evm.model.CM009519.1.424 Q86TM6 SYVN1_HUMAN 94.003 0.996732 0.991896 SYVN1 - E3 ubiquitin-protein ligase synoviolin - Homo sapiens (Human) - SYVN1 gene E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28827405). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28842558). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity). During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (By similarity). Indicus|evm.model.CM009519.1.425 Q5MJ68 SPDYC_HUMAN 65.672 0.858553 1.03754 SPDYC - Speedy protein C - Homo sapiens (Human) - SPDYC gene Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase. Indicus|evm.model.CM009519.1.426 Q27970 CAN1_BOVIN 100.000 0.547771 1.75419 CAPN1 - Calpain-1 catalytic subunit - Bos taurus (Bovine) - CAPN1 gene Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1. Indicus|evm.model.CM009519.1.427 Q58D13 DPOA2_BOVIN 99.637 0.915141 0.995033 POLA2 - DNA polymerase alpha subunit B - Bos taurus (Bovine) - POLA2 gene Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). Indicus|evm.model.CM009519.1.428 Q08DN6 BORG1_BOVIN 100.000 0.990521 1.00476 CDC42EP2 - Cdc42 effector protein 2 - Bos taurus (Bovine) - CDC42EP2 gene Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Indicus|evm.model.CM009519.1.429 Q92785 REQU_HUMAN 99.744 0.994898 1.00256 DPF2 - Zinc finger protein ubi-d4 - Homo sapiens (Human) - DPF2 gene Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). Indicus|evm.model.CM009519.1.430 Q6B0B8 TIGD3_HUMAN 84.713 0.995763 1.00212 TIGD3 - Tigger transposable element-derived protein 3 - Homo sapiens (Human) - TIGD3 gene nucleus, DNA binding Indicus|evm.model.CM009519.1.431 Q8N413 S2545_HUMAN 89.236 0.99308 1.00347 SLC25A45 - Solute carrier family 25 member 45 - Homo sapiens (Human) - SLC25A45 gene acyl carnitine transmembrane transporter activity, acyl carnitine transport, amino acid transport Indicus|evm.model.CM009519.1.432 Q9BZ67 FRMD8_HUMAN 87.742 0.99569 1 FRMD8 - FERM domain-containing protein 8 - Homo sapiens (Human) - FRMD8 gene Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). Indicus|evm.model.CM009519.1.433 A6QLH6 SCYL1_BOVIN 99.752 0.997525 1.00124 SCYL1 - N-terminal kinase-like protein - Bos taurus (Bovine) - SCYL1 gene Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro. Indicus|evm.model.CM009519.1.434 Q9NS15 LTBP3_HUMAN 95.140 0.99835 0.930161 LTBP3 - Latent-transforming growth factor beta-binding protein 3 precursor - Homo sapiens (Human) - LTBP3 gene Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Indicus|evm.model.CM009519.1.435 O60232 ZNRD2_HUMAN 95.477 0.99 1.00503 ZNRD2 - Protein ZNRD2 - Homo sapiens (Human) - ZNRD2 gene Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies. Indicus|evm.model.CM009519.1.436 Q8N5H3 LRA25_HUMAN 94.271 0.989637 1.02116 FAM89B - Leucine repeat adapter protein 25 - Homo sapiens (Human) - FAM89B gene Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Indicus|evm.model.CM009519.1.437 Q8N3D4 EH1L1_HUMAN 92.486 0.130008 0.86868 EHBP1L1 - EH domain-binding protein 1-like protein 1 - Homo sapiens (Human) - EHBP1L1 gene May act as Rab effector protein and play a role in vesicle trafficking. Indicus|evm.model.CM009519.1.438 Q9Y2U2 KCNK7_HUMAN 81.107 0.993506 1.00326 KCNK7 - Potassium channel subfamily K member 7 - Homo sapiens (Human) - KCNK7 gene Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane. Indicus|evm.model.CM009519.1.439 Q16584 M3K11_HUMAN 92.014 0.997688 1.02125 MAP3K11 - Mitogen-activated protein kinase kinase kinase 11 - Homo sapiens (Human) - MAP3K11 gene Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. Indicus|evm.model.CM009519.1.440 Q9H6A9 PCX3_HUMAN 93.880 0.999034 1.0177 PCNX3 - Pecanex-like protein 3 - Homo sapiens (Human) - PCNX3 gene Indicus|evm.model.CM009519.1.441 Q96FS4 SIPA1_HUMAN 91.544 0.638073 0.816699 SIPA1 - Signal-induced proliferation-associated protein 1 - Homo sapiens (Human) - SIPA1 gene GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). Indicus|evm.model.CM009519.1.442 Q04206 TF65_HUMAN 88.592 0.996377 1.00181 RELA - Transcription factor p65 - Homo sapiens (Human) - RELA gene NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). Indicus|evm.model.CM009519.1.443 Q99MK2 KAT5_RAT 99.805 0.996109 1.00195 Kat5 - Histone acetyltransferase KAT5 - Rattus norvegicus (Rat) - Kat5 gene Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer. Directly acetylates and activates ATM. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity. Acetylates RAN at 'Lys-134'. Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer. Indicus|evm.model.CM009519.1.444 Q2M2U4 RNH2C_BOVIN 100.000 0.987952 1.00606 RNASEH2C - Ribonuclease H2 subunit C - Bos taurus (Bovine) - RNASEH2C gene Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). Indicus|evm.model.CM009519.1.445 G3MZC5 AP5B1_BOVIN 100.000 0.997722 1.00114 AP5B1 - AP-5 complex subunit beta-1 - Bos taurus (Bovine) - AP5B1 gene As part of AP-5, a probable fifth adaptor protein complex, it may be involved in endosomal transport. Indicus|evm.model.CM009519.1.446 A2VDT4 OVOL1_BOVIN 100.000 0.992537 1.00375 OVOL1 - Putative transcription factor Ovo-like 1 - Bos taurus (Bovine) - OVOL1 gene Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity). Indicus|evm.model.CM009519.1.449 Q6B7M7 COF1_SHEEP 100.000 0.988024 1.00602 CFL1 - Cofilin-1 - Ovis aries (Sheep) - CFL1 gene Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (By similarity). Important for normal progress through mitosis and normal cytokinesis (By similarity). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity). Indicus|evm.model.CM009519.1.450 Q96NY9 MUS81_HUMAN 86.594 0.996383 1.00363 MUS81 - Crossover junction endonuclease MUS81 - Homo sapiens (Human) - MUS81 gene Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. Indicus|evm.model.CM009519.1.451 O55058 FBLN4_CRIGR 97.065 0.995495 1.00226 EFEMP2 - EGF-containing fibulin-like extracellular matrix protein 2 precursor - Cricetulus griseus (Chinese hamster) - EFEMP2 gene Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling. Indicus|evm.model.CM009519.1.452 Q9TST1 CATW_FELCA 72.872 0.994667 1.00267 CTSW - Cathepsin W precursor - Felis catus (Cat) - CTSW gene May have a specific function in the mechanism or regulation of T-cell cytolytic activity. Indicus|evm.model.CM009519.1.453 O46431 FIBP_CHLAE 98.880 0.994413 1.0028 FIBP - Acidic fibroblast growth factor intracellular-binding protein - Chlorocebus aethiops (Green monkey) - FIBP gene May be involved in mitogenic function of FGF1 (By similarity). May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity). Indicus|evm.model.CM009519.1.454 Q6PDY0 CC85B_MOUSE 98.020 0.990148 1.00495 Ccdc85b - Coiled-coil domain-containing protein 85B - Mus musculus (Mouse) - Ccdc85b gene Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (PubMed:15644333, PubMed:22666460). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). Indicus|evm.model.CM009519.1.455 P15407 FOSL1_HUMAN 91.241 0.992647 1.00369 FOSL1 - Fos-related antigen 1 - Homo sapiens (Human) - FOSL1 gene chromatin, nucleoplasm, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, cellular defense response, chemotaxis, positive regulation of cell population proliferation Indicus|evm.model.CM009519.1.456 A4IFA8 CK068_BOVIN 99.658 0.993174 1.00342 UPF0696 protein C11orf68 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.457 Q2YDP3 NC2A_BOVIN 100.000 0.990291 1.00488 DRAP1 - Dr1-associated corepressor - Bos taurus (Bovine) - DRAP1 gene The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). Indicus|evm.model.CM009519.1.458 A5D7I0 T10IP_BOVIN 99.460 0.996409 1.0018 TSGA10IP - Testis-specific protein 10-interacting protein - Bos taurus (Bovine) - TSGA10IP gene photoreceptor connecting cilium, cilium organization Indicus|evm.model.CM009519.1.459 Q9Z315 SNUT1_MOUSE 93.921 0.997509 0.996278 Sart1 - U4/U6.U5 tri-snRNP-associated protein 1 - Mus musculus (Mouse) - Sart1 gene Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Appears to play a role in hypoxia-induced regulation of EPO gene expression. Indicus|evm.model.CM009519.1.460 Q58CY2 EIF1A_BOVIN 100.000 0.988024 1.00602 EIF1AD - Probable RNA-binding protein EIF1AD - Bos taurus (Bovine) - EIF1AD gene Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity). Indicus|evm.model.CM009519.1.461 Q5RBU9 BAF_PONAB 100.000 0.606897 1.62921 BANF1 - Barrier-to-autointegration factor - Pongo abelii (Sumatran orangutan) - BANF1 gene Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Indicus|evm.model.CM009519.1.462 Q8NEC5 CTSR1_HUMAN 73.810 0.282759 0.185897 CATSPER1 - Cation channel sperm-associated protein 1 - Homo sapiens (Human) - CATSPER1 gene Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Indicus|evm.model.CM009519.1.463 Q15828 CYTM_HUMAN 79.452 0.097561 4.95302 CST6 - Cystatin-M precursor - Homo sapiens (Human) - CST6 gene High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain (PubMed:30425301). Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance (PubMed:30425301). Indicus|evm.model.CM009519.1.464 Q0VCH4 G3ST3_BOVIN 85.948 0.994609 0.868852 GAL3ST3 - Galactose-3-O-sulfotransferase 3 - Bos taurus (Bovine) - GAL3ST3 gene Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc (By similarity). Indicus|evm.model.CM009519.1.465 Q13435 SF3B2_HUMAN 97.216 0.997768 1.00112 SF3B2 - Splicing factor 3B subunit 2 - Homo sapiens (Human) - SF3B2 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). Indicus|evm.model.CM009519.1.467 P62752 RL23A_RAT 95.745 0.596154 1 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009519.1.468 Q6VY07 PACS1_HUMAN 97.423 0.993895 0.850467 PACS1 - Phosphofurin acidic cluster sorting protein 1 - Homo sapiens (Human) - PACS1 gene Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Indicus|evm.model.CM009519.1.469 Q9H0B6 KLC2_HUMAN 94.286 0.614907 1.55305 KLC2 - Kinesin light chain 2 - Homo sapiens (Human) - KLC2 gene Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). Indicus|evm.model.CM009519.1.470 Q3T196 YIF1A_BOVIN 100.000 0.993197 1.00341 YIF1A - Protein YIF1A - Bos taurus (Bovine) - YIF1A gene Possible role in transport between endoplasmic reticulum and Golgi. Indicus|evm.model.CM009519.1.471 A4IFG4 T151B_BOVIN 99.775 0.958874 0.987179 TMEM151B - Transmembrane protein 151B - Bos taurus (Bovine) - TMEM151B gene Indicus|evm.model.CM009519.1.472 Q9HCU0 CD248_HUMAN 78.553 0.98062 1.02246 CD248 - Endosialin precursor - Homo sapiens (Human) - CD248 gene May play a role in tumor angiogenesis. Indicus|evm.model.CM009519.1.473 Q13671 RIN1_HUMAN 83.418 0.997472 1.01022 RIN1 - Ras and Rab interactor 1 - Homo sapiens (Human) - RIN1 gene Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Indicus|evm.model.CM009519.1.474 Q1LZE0 BRMS1_BOVIN 100.000 0.822148 1.21138 BRMS1 - Breast cancer metastasis-suppressor 1 homolog - Bos taurus (Bovine) - BRMS1 gene Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity). Indicus|evm.model.CM009519.1.475 Q5EA01 B4GA1_BOVIN 100.000 0.995192 1.00241 B4GAT1 - Beta-1,4-glucuronyltransferase 1 - Bos taurus (Bovine) - B4GAT1 gene Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1). Indicus|evm.model.CM009519.1.476 Q14542 S29A2_HUMAN 81.702 0.995726 1.02632 SLC29A2 - Equilibrative nucleoside transporter 2 - Homo sapiens (Human) - SLC29A2 gene Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. Indicus|evm.model.CM009519.1.477 Q8IUM7 NPAS4_HUMAN 92.662 0.997497 0.996259 NPAS4 - Neuronal PAS domain-containing protein 4 - Homo sapiens (Human) - NPAS4 gene Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734). Indicus|evm.model.CM009519.1.478 Q2YDI0 RM11_BOVIN 100.000 0.989637 1.00521 MRPL11 - 39S ribosomal protein L11, mitochondrial precursor - Bos taurus (Bovine) - MRPL11 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Indicus|evm.model.CM009519.1.479 Q8BXR6 PELI3_MOUSE 96.854 0.995516 1.00225 Peli3 - E3 ubiquitin-protein ligase pellino homolog 3 - Mus musculus (Mouse) - Peli3 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. Indicus|evm.model.CM009519.1.480 Q9NY33 DPP3_HUMAN 94.787 0.970667 1.01764 DPP3 - Dipeptidyl peptidase 3 - Homo sapiens (Human) - DPP3 gene Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758). Indicus|evm.model.CM009519.1.481 Q8NFJ9 BBS1_HUMAN 87.241 0.976391 1 BBS1 - Bardet-Biedl syndrome 1 protein - Homo sapiens (Human) - BBS1 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986). Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity). Indicus|evm.model.CM009519.1.482 Q6UX98 ZDH24_HUMAN 93.310 0.992982 1.00352 ZDHHC24 - Probable palmitoyltransferase ZDHHC24 - Homo sapiens (Human) - ZDHHC24 gene Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Indicus|evm.model.CM009519.1.483 Q0III9 ACTN3_BOVIN 97.891 0.997738 0.981132 ACTN3 - Alpha-actinin-3 - Bos taurus (Bovine) - ACTN3 gene F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). Indicus|evm.model.CM009519.1.484 Q9R013 CATF_MOUSE 78.652 0.963124 0.997835 Ctsf - Cathepsin F precursor - Mus musculus (Mouse) - Ctsf gene Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Indicus|evm.model.CM009519.1.485 Q9NVE4 CCD87_HUMAN 65.562 0.977855 1.0106 CCDC87 - Coiled-coil domain-containing protein 87 - Homo sapiens (Human) - CCDC87 gene Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility. Indicus|evm.model.CM009519.1.486 Q6PWT7 CCS_PIG 92.336 0.992727 1.00365 CCS - Copper chaperone for superoxide dismutase - Sus scrofa (Pig) - CCS gene Delivers copper to copper zinc superoxide dismutase (SOD1). Indicus|evm.model.CM009519.1.487 Q5EA36 RBM14_BOVIN 100.000 0.940678 0.176383 RBM14 - RNA-binding protein 14 - Bos taurus (Bovine) - RBM14 gene May function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009519.1.488 Q3MHX3 RBM4_BOVIN 100.000 0.99449 1.00276 RBM4 - RNA-binding protein 4 - Bos taurus (Bovine) - RBM4 gene RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro (By similarity). Indicus|evm.model.CM009519.1.489 Q06AT9 RBM4B_PIG 98.607 0.94709 1.05292 RBM4B - RNA-binding protein 4B - Sus scrofa (Pig) - RBM4B gene Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity). Indicus|evm.model.CM009519.1.490 O15020 SPTN2_HUMAN 93.464 0.990253 0.643933 SPTBN2 - Spectrin beta chain, non-erythrocytic 2 - Homo sapiens (Human) - SPTBN2 gene Probably plays an important role in neuronal membrane skeleton. Indicus|evm.model.CM009519.1.491 Q8N6T0 TO6BL_HUMAN 70.297 0.995943 0.854419 TOP6BL - Type 2 DNA topoisomerase 6 subunit B-like - Homo sapiens (Human) - TOP6BL gene Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Indicus|evm.model.CM009519.1.492 Q9Y256 FACE2_HUMAN 98.176 0.993939 1.00304 RCE1 - CAAX prenyl protease 2 - Homo sapiens (Human) - RCE1 gene Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068). Indicus|evm.model.CM009519.1.493 Q29RK2 PYC_BOVIN 100.000 0.996613 1.00255 PC - Pyruvate carboxylase, mitochondrial precursor - Bos taurus (Bovine) - PC gene Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (By similarity). Indicus|evm.model.CM009519.1.494 Q2KIL8 CK086_BOVIN 100.000 0.98374 1.0082 Uncharacterized protein C11orf86 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009519.1.495 Q8IV01 SYT12_HUMAN 96.437 0.995261 1.00238 SYT12 - Synaptotagmin-12 - Homo sapiens (Human) - SYT12 gene Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (By similarity). Essential for mossy-fiber long-term potentiation in the hippocampus (By similarity). Indicus|evm.model.CM009519.1.496 O00212 RHOD_HUMAN 89.048 0.990521 1.00476 RHOD - Rho-related GTP-binding protein RhoD precursor - Homo sapiens (Human) - RHOD gene Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. Indicus|evm.model.CM009519.1.498 Q9Y2K7 KDM2A_HUMAN 96.830 0.672195 0.8821 KDM2A - Lysine-specific demethylase 2A - Homo sapiens (Human) - KDM2A gene Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). Indicus|evm.model.CM009519.1.499 P21146 ARBK1_BOVIN 98.624 0.496956 1.90711 GRK2 - Beta-adrenergic receptor kinase 1 - Bos taurus (Bovine) - GRK2 gene Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity). Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (PubMed:21659505). Inhibits relaxation of airway smooth muscle in response to blue light (By similarity). Indicus|evm.model.CM009519.1.500 Q5XIS1 SSH3_RAT 81.860 0.995385 0.996933 Ssh3 - Protein phosphatase Slingshot homolog 3 - Rattus norvegicus (Rat) - Ssh3 gene Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). Indicus|evm.model.CM009519.1.501 Q3T0X9 DPOD4_BOVIN 100.000 0.981481 1.00935 POLD4 - DNA polymerase delta subunit 4 - Bos taurus (Bovine) - POLD4 gene As a component of the tetrameric DNA polymerase delta 4 complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites. Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival. Indicus|evm.model.CM009519.1.502 Q9UBD9 CLCF1_HUMAN 93.491 0.827586 0.902222 CLCF1 - Cardiotrophin-like cytokine factor 1 precursor - Homo sapiens (Human) - CLCF1 gene In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor. Indicus|evm.model.CM009519.1.503 Q99638 RAD9A_HUMAN 88.101 0.994949 1.01279 RAD9A - Cell cycle checkpoint control protein RAD9A - Homo sapiens (Human) - RAD9A gene Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex. Indicus|evm.model.CM009519.1.504 P62138 PP1A_RAT 100.000 0.923333 0.909091 Ppp1ca - Serine/threonine-protein phosphatase PP1-alpha catalytic subunit - Rattus norvegicus (Rat) - Ppp1ca gene Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity). Indicus|evm.model.CM009519.1.505 Q8IV04 TB10C_HUMAN 92.601 0.995526 1.00224 TBC1D10C - Carabin - Homo sapiens (Human) - TBC1D10C gene Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras. Indicus|evm.model.CM009519.1.506 A5YM72 CRNS1_HUMAN 88.029 0.864662 1.12576 CARNS1 - Carnosine synthase 1 - Homo sapiens (Human) - CARNS1 gene Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. Indicus|evm.model.CM009519.1.507 Q9UBS0 KS6B2_HUMAN 94.639 0.995885 1.0083 RPS6KB2 - Ribosomal protein S6 kinase beta-2 - Homo sapiens (Human) - RPS6KB2 gene Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). Indicus|evm.model.CM009519.1.508 Q14761 PTCA_HUMAN 71.359 0.990148 0.985437 PTPRCAP - Protein tyrosine phosphatase receptor type C-associated protein - Homo sapiens (Human) - PTPRCAP gene plasma membrane, defense response Indicus|evm.model.CM009519.1.509 Q5NVK4 COR1B_PONAB 92.813 0.925714 1.07362 CORO1B - Coronin-1B - Pongo abelii (Sumatran orangutan) - CORO1B gene Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). Indicus|evm.model.CM009519.1.510 Q8TDT2 GP152_HUMAN 78.112 0.995556 0.957447 GPR152 - Probable G-protein coupled receptor 152 - Homo sapiens (Human) - GPR152 gene Orphan receptor. Indicus|evm.model.CM009519.1.511 Q8HZJ4 CABP4_BOVIN 99.642 0.992857 1.00358 CABP4 - Calcium-binding protein 4 - Bos taurus (Bovine) - CABP4 gene May play a role in normal synaptic function, probably through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1F, shifting the activation range to more hyperpolarized voltages (By similarity). Indicus|evm.model.CM009519.1.512 Q05B54 TM134_BOVIN 100.000 0.989796 1.00513 TMEM134 - Transmembrane protein 134 - Bos taurus (Bovine) - TMEM134 gene Indicus|evm.model.CM009519.1.514 Q7YRC1 AIP_BOVIN 97.879 0.993958 1.00303 AIP - AH receptor-interacting protein - Bos taurus (Bovine) - AIP gene May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Indicus|evm.model.CM009519.1.515 O00562 PITM1_HUMAN 90.369 0.998347 0.972669 PITPNM1 - Membrane-associated phosphatidylinositol transfer protein 1 - Homo sapiens (Human) - PITPNM1 gene Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:22822086, PubMed:10531358). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). Indicus|evm.model.CM009519.1.516 Q58CN7 CDKA2_BOVIN 100.000 0.984375 1.00787 CDK2AP2 - Cyclin-dependent kinase 2-associated protein 2 - Bos taurus (Bovine) - CDK2AP2 gene Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A. Indicus|evm.model.CM009519.1.517 Q9N1Q9 CABP2_BOVIN 100.000 0.440625 1.96319 CABP2 - Calcium-binding protein 2 - Bos taurus (Bovine) - CABP2 gene Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs. Required for the normal transfer of light signals through the retina. Indicus|evm.model.CM009519.1.518 P46424 GSTP1_CRILO 79.904 0.985782 1.00476 GSTP1 - Glutathione S-transferase P - Cricetulus longicaudatus (Long-tailed dwarf hamster) - GSTP1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Indicus|evm.model.CM009519.1.519 P28801 GSTP1_BOVIN 99.524 0.870833 1.14286 GSTP1 - Glutathione S-transferase P - Bos taurus (Bovine) - GSTP1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Indicus|evm.model.CM009519.1.520 P25708 NDUV1_BOVIN 100.000 0.995699 1.00216 NDUFV1 - NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor - Bos taurus (Bovine) - NDUFV1 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Indicus|evm.model.CM009519.1.521 Q9ESN1 DOC2G_MOUSE 72.368 0.990937 0.855297 Doc2g - Double C2-like domain-containing protein gamma - Mus musculus (Mouse) - Doc2g gene May be involved in regulation of vesicular trafficking. In vitro, does not bind calcium and phospholipids. Indicus|evm.model.CM009519.1.522 O75333 TBX10_HUMAN 85.329 0.314585 2.72468 TBX10 - T-box transcription factor TBX10 - Homo sapiens (Human) - TBX10 gene Probable transcriptional regulator involved in developmental processes. Indicus|evm.model.CM009519.1.523 Q9H1C4 UN93B_HUMAN 92.397 0.9967 1.01508 UNC93B1 - Protein unc-93 homolog B1 - Homo sapiens (Human) - UNC93B1 gene Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. Indicus|evm.model.CM009519.1.524 Q1JPA0 AL3B1_BOVIN 99.573 0.903288 1.1047 ALDH3B1 - Aldehyde dehydrogenase family 3 member B1 precursor - Bos taurus (Bovine) - ALDH3B1 gene Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor. May have a protective role against the cytotoxicity induced by lipid peroxidation. Indicus|evm.model.CM009519.1.526 P42028 NDUS8_BOVIN 100.000 0.875519 1.13679 NDUFS8 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial precursor - Bos taurus (Bovine) - NDUFS8 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for the catalytic activity and assembly of complex I (By similarity). Indicus|evm.model.CM009519.1.527 Q13488 VPP3_HUMAN 81.250 0.913793 0.209639 TCIRG1 - V-type proton ATPase 116 kDa subunit a3 - Homo sapiens (Human) - TCIRG1 gene Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. Indicus|evm.model.CM009519.1.528 Q13488 VPP3_HUMAN 86.000 0.949045 0.189157 TCIRG1 - V-type proton ATPase 116 kDa subunit a3 - Homo sapiens (Human) - TCIRG1 gene Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. Indicus|evm.model.CM009519.1.529 Q13488 VPP3_HUMAN 79.830 0.994286 0.421687 TCIRG1 - V-type proton ATPase 116 kDa subunit a3 - Homo sapiens (Human) - TCIRG1 gene Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. Indicus|evm.model.CM009519.1.530 P35790 CHKA_HUMAN 91.471 0.885117 0.838074 CHKA - Choline kinase alpha - Homo sapiens (Human) - CHKA gene Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. Indicus|evm.model.CM009519.1.531 Q29RP8 KMT5B_BOVIN 99.745 0.442308 2.24936 KMT5B - Histone-lysine N-methyltransferase KMT5B - Bos taurus (Bovine) - KMT5B gene Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). Indicus|evm.model.CM009519.1.534 P62752 RL23A_RAT 68.421 0.972477 0.698718 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009519.1.535 O75197 LRP5_HUMAN 97.037 0.973587 1.00805 LRP5 - Low-density lipoprotein receptor-related protein 5 precursor - Homo sapiens (Human) - LRP5 gene Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins (PubMed:11336703, PubMed:11448771, PubMed:15778503, PubMed:11719191, PubMed:15908424, PubMed:16252235). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11336703, PubMed:11719191). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11719191). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (PubMed:11336703, PubMed:25920554, PubMed:24706814, PubMed:14731402). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (PubMed:27228167, PubMed:16252235). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (By similarity). Indicus|evm.model.CM009519.1.536 Q5H9R7 PP6R3_HUMAN 95.991 0.997712 1.00115 PPP6R3 - Serine/threonine-protein phosphatase 6 regulatory subunit 3 - Homo sapiens (Human) - PPP6R3 gene Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. Indicus|evm.model.CM009519.1.537 P11242 GALA_BOVIN 97.895 0.328671 2.3252 GAL - Galanin peptides precursor - Bos taurus (Bovine) - GAL gene Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion. Indicus|evm.model.CM009519.1.538 Q9Y4I5 MTL5_HUMAN 79.297 0.996094 1.00787 TESMIN - Tesmin - Homo sapiens (Human) - TESMIN gene May have a role in spermatogenesis. Indicus|evm.model.CM009519.1.539 P50416 CPT1A_HUMAN 89.651 0.997416 1.00129 CPT1A - Carnitine O-palmitoyltransferase 1, liver isoform - Homo sapiens (Human) - CPT1A gene Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:9691089, PubMed:11350182, PubMed:14517221). Plays an important role in hepatic triglyceride metabolism (By similarity). Indicus|evm.model.CM009519.1.540 Q2TBS2 RM21_BOVIN 97.608 0.990476 1.00478 MRPL21 - 39S ribosomal protein L21, mitochondrial precursor - Bos taurus (Bovine) - MRPL21 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Indicus|evm.model.CM009519.1.541 P38935 SMBP2_HUMAN 78.937 0.913246 1.07956 IGHMBP2 - DNA-binding protein SMUBP-2 - Homo sapiens (Human) - IGHMBP2 gene 5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV. Indicus|evm.model.CM009519.1.543 Q6L786 MRGRD_MACFA 54.921 0.975 1 MRGPRD - Mas-related G-protein coupled receptor member D - Macaca fascicularis (Crab-eating macaque) - MRGPRD gene May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) (By similarity). Indicus|evm.model.CM009519.1.544 Q96AM1 MRGRF_HUMAN 88.921 0.994186 1.00292 MRGPRF - Mas-related G-protein coupled receptor member F - Homo sapiens (Human) - MRGPRF gene Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). Indicus|evm.model.CM009519.1.545 Q8NHX9 TPC2_HUMAN 78.532 0.843897 1.13298 TPCN2 - Two pore calcium channel protein 2 - Homo sapiens (Human) - TPCN2 gene Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. Indicus|evm.model.CM009519.1.551 Q2KI22 CCND1_BOVIN 100.000 0.993243 1.00339 CCND1 - G1/S-specific cyclin-D1 - Bos taurus (Bovine) - CCND1 gene Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). Indicus|evm.model.CM009519.1.552 Q8WV07 LTO1_HUMAN 89.781 0.985507 1.0073 LTO1 - Protein LTO1 homolog - Homo sapiens (Human) - LTO1 gene The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452). May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674). Indicus|evm.model.CM009519.1.553 O95750 FGF19_HUMAN 75.000 0.726644 1.33796 FGF19 - Fibroblast growth factor 19 precursor - Homo sapiens (Human) - FGF19 gene Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Indicus|evm.model.CM009519.1.555 P48803 FGF4_BOVIN 100.000 0.90099 0.490291 FGF4 - Fibroblast growth factor 4 precursor - Bos taurus (Bovine) - FGF4 gene Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). Indicus|evm.model.CM009519.1.556 P11487 FGF3_HUMAN 78.065 0.905882 0.711297 FGF3 - Fibroblast growth factor 3 precursor - Homo sapiens (Human) - FGF3 gene Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. Indicus|evm.model.CM009519.1.557 Q8BHY3 ANO1_MOUSE 97.143 0.0372807 0.95 Ano1 - Anoctamin-1 - Mus musculus (Mouse) - Ano1 gene Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction (PubMed:28561733, PubMed:29236691, PubMed:29236684). Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Indicus|evm.model.CM009519.1.558 Q645M6 FADD_BOVIN 100.000 0.990476 1.00478 FADD - FAS-associated death domain protein - Bos taurus (Bovine) - FADD gene Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. Indicus|evm.model.CM009519.1.559 A3KN12 PUR8_BOVIN 61.570 0.675 0.571429 ADSL - Adenylosuccinate lyase - Bos taurus (Bovine) - ADSL gene Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. Indicus|evm.model.CM009519.1.560 Q13136 LIPA1_HUMAN 94.093 0.899625 1.11065 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Indicus|evm.model.CM009519.1.562 Q60598 SRC8_MOUSE 88.645 0.996289 0.987179 Cttn - Src substrate cortactin - Mus musculus (Mouse) - Cttn gene Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:17403031). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (PubMed:22262902). Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (By similarity). Indicus|evm.model.CM009519.1.563 Q9UPX8 SHAN2_HUMAN 86.867 0.785363 1.24558 SHANK2 - SH3 and multiple ankyrin repeat domains protein 2 - Homo sapiens (Human) - SHANK2 gene Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. Indicus|evm.model.CM009519.1.565 P10995 ACT2_XENLA 50.546 0.978495 0.986737 act2 - Actin, alpha skeletal muscle 2 precursor - Xenopus laevis (African clawed frog) - act2 gene Actins are highly conserved proteins that are involved in various types of cell motility. Indicus|evm.model.CM009519.1.566 Q5E9J5 DHCR7_BOVIN 94.105 0.913828 1.05053 DHCR7 - 7-dehydrocholesterol reductase - Bos taurus (Bovine) - DHCR7 gene 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermidiates in that pathway. Indicus|evm.model.CM009519.1.567 Q3ZBF0 NADE_BOVIN 99.575 0.997171 1.00142 NADSYN1 - Glutamine-dependent NAD(+) synthetase - Bos taurus (Bovine) - NADSYN1 gene Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. Indicus|evm.model.CM009519.1.569 Q86SM5 MRGRG_HUMAN 65.965 0.73385 1.3391 MRGPRG - Mas-related G-protein coupled receptor member G - Homo sapiens (Human) - MRGPRG gene Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). Indicus|evm.model.CM009519.1.571 Q9H0X9 OSBL5_HUMAN 87.727 0.967814 1.02503 OSBPL5 - Oxysterol-binding protein-related protein 5 - Homo sapiens (Human) - OSBPL5 gene Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). Indicus|evm.model.CM009519.1.573 Q4R550 SYCC_MACFA 81.081 0.83882 1.17781 CARS1 - Cysteine--tRNA ligase, cytoplasmic - Macaca fascicularis (Crab-eating macaque) - CARS1 gene Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). Indicus|evm.model.CM009519.1.574 Q2TA40 NP1L4_BOVIN 92.269 0.913242 1.13472 NAP1L4 - Nucleosome assembly protein 1-like 4 - Bos taurus (Bovine) - NAP1L4 gene Acts as histone chaperone in nucleosome assembly. Indicus|evm.model.CM009519.1.576 Q0VC85 PHLA2_BOVIN 100.000 0.429825 1.60563 PHLDA2 - Pleckstrin homology-like domain family A member 2 - Bos taurus (Bovine) - PHLDA2 gene Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). Indicus|evm.model.CM009519.1.577 Q96BI1 S22AI_HUMAN 79.009 0.995294 1.00236 SLC22A18 - Solute carrier family 22 member 18 - Homo sapiens (Human) - SLC22A18 gene May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Indicus|evm.model.CM009519.1.578 P49918 CDN1C_HUMAN 77.778 0.533865 0.794304 CDKN1C - Cyclin-dependent kinase inhibitor 1C - Homo sapiens (Human) - CDKN1C gene Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. Indicus|evm.model.CM009519.1.579 Q9TTJ7 KCNQ1_PIG 87.081 0.990476 0.312036 KCNQ1 - Potassium voltage-gated channel subfamily KQT member 1 - Sus scrofa (Pig) - KCNQ1 gene Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (By similarity). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (By similarity). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). When associated with KCNE4, inhibits voltage-gated potassium channel activity (By similarity). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (By similarity). Also forms a heterotetramer with KCNQ5 that has a voltage-gated potassium channel activity (By similarity). Binds with phosphatidylinositol 4,5-bisphosphate (By similarity). Indicus|evm.model.CM009519.1.581 Q9TTJ7 KCNQ1_PIG 63.158 0.293194 0.283804 KCNQ1 - Potassium voltage-gated channel subfamily KQT member 1 - Sus scrofa (Pig) - KCNQ1 gene Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (By similarity). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (By similarity). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). When associated with KCNE4, inhibits voltage-gated potassium channel activity (By similarity). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (By similarity). Also forms a heterotetramer with KCNQ5 that has a voltage-gated potassium channel activity (By similarity). Binds with phosphatidylinositol 4,5-bisphosphate (By similarity). Indicus|evm.model.CM009519.1.582 Q9NZQ8 TRPM5_HUMAN 76.890 0.955437 0.96309 TRPM5 - Transient receptor potential cation channel subfamily M member 5 - Homo sapiens (Human) - TRPM5 gene Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. Indicus|evm.model.CM009519.1.583 Q1LZD3 TSSC4_BOVIN 99.692 0.993865 1.00308 TSSC4 - Protein TSSC4 - Bos taurus (Bovine) - TSSC4 gene Indicus|evm.model.CM009519.1.584 Q3ZCD0 CD81_BOVIN 100.000 0.714765 1.26271 CD81 - CD81 antigen - Bos taurus (Bovine) - CD81 gene Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype. Present in MHC class II compartments, may also play a role in antigen presentation (By similarity). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction. In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (By similarity). Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity). Indicus|evm.model.CM009519.1.585 Q96QS1 TSN32_HUMAN 54.710 0.937063 0.89375 TSPAN32 - Tetraspanin-32 - Homo sapiens (Human) - TSPAN32 gene integral component of plasma membrane, cell-cell signaling, protein localization to plasma membrane, protein maturation Indicus|evm.model.CM009519.1.586 Q2EGB9 ASCL2_BOVIN 99.482 0.989691 1.00518 ASCL2 - Achaete-scute homolog 2 - Bos taurus (Bovine) - ASCL2 gene AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Indicus|evm.model.CM009519.1.587 P17289 TY3H_BOVIN 98.413 0.438228 0.873727 TH - Tyrosine 3-monooxygenase - Bos taurus (Bovine) - TH gene Plays an important role in the physiology of adrenergic neurons (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). Indicus|evm.model.CM009519.1.588 P01318 INS_SHEEP 97.143 0.541667 1.82857 INS - Insulin precursor - Ovis aries (Sheep) - INS gene Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Indicus|evm.model.CM009519.1.589 P07456 IGF2_BOVIN 100.000 0.754237 1.31844 IGF2 - Insulin-like growth factor II precursor - Bos taurus (Bovine) - IGF2 gene The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity). Indicus|evm.model.CM009519.1.593 Q16540 RM23_HUMAN 83.439 0.987261 1.02614 MRPL23 - 39S ribosomal protein L23, mitochondrial - Homo sapiens (Human) - MRPL23 gene fibrillar center, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, RNA binding, structural constituent of ribosome, mitochondrial translation, mitochondrial translational elongation, mitochondrial translational termination, translation Indicus|evm.model.CM009519.1.594 Q8MKI3 TNNT3_BOVIN 98.155 0.849359 1.15129 Tnnt3 - Troponin T, fast skeletal muscle - Bos taurus (Bovine) - Tnnt3 gene Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Indicus|evm.model.CM009519.1.595 Q8C494 PRR33_MOUSE 58.893 0.477186 2.02308 Prr33 - Proline-rich protein 33 - Mus musculus (Mouse) - Prr33 gene response to wounding Indicus|evm.model.CM009519.1.596 P33241 LSP1_HUMAN 67.033 0.994505 1.07375 LSP1 - Lymphocyte-specific protein 1 - Homo sapiens (Human) - LSP1 gene May play a role in mediating neutrophil activation and chemotaxis. Indicus|evm.model.CM009519.1.597 P02643 TNNI2_RABIT 95.604 0.989071 1.00549 TNNI2 - Troponin I, fast skeletal muscle - Oryctolagus cuniculus (Rabbit) - TNNI2 gene Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Indicus|evm.model.CM009519.1.599 P80209 CATD_BOVIN 97.949 0.941889 1.05897 CTSD - Cathepsin D precursor - Bos taurus (Bovine) - CTSD gene Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Indicus|evm.model.CM009519.1.600 Q9HC73 CRLF2_HUMAN 56.349 0.582938 1.7062 CRLF2 - Cytokine receptor-like factor 2 precursor - Homo sapiens (Human) - CRLF2 gene Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. Indicus|evm.model.CM009519.1.601 Q6W4X9 MUC6_HUMAN 60.215 0.867925 0.0434604 MUC6 - Mucin-6 precursor - Homo sapiens (Human) - MUC6 gene May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Indicus|evm.model.CM009519.1.602 Q0VCK5 AP2A2_BOVIN 94.317 0.993174 0.9371 AP2A2 - AP-2 complex subunit alpha-2 - Bos taurus (Bovine) - AP2A2 gene Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). Indicus|evm.model.CM009519.1.603 A6NMD0 IFM10_HUMAN 98.000 0.884444 0.986842 IFITM10 - Interferon-induced transmembrane protein 10 - Homo sapiens (Human) - IFITM10 gene plasma membrane Indicus|evm.model.CM009519.1.606 Q5EAB4 CHID1_BOVIN 99.746 0.994924 1.00254 CHID1 - Chitinase domain-containing protein 1 precursor - Bos taurus (Bovine) - CHID1 gene Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity). Indicus|evm.model.CM009519.1.607 Q5RAP3 TSN4_PONAB 93.277 0.991632 1.0042 TSPAN4 - Tetraspanin-4 - Pongo abelii (Sumatran orangutan) - TSPAN4 gene Indicus|evm.model.CM009519.1.609 Q7Z3B4 NUP54_HUMAN 97.899 0.918605 0.508876 NUP54 - Nucleoporin p54 - Homo sapiens (Human) - NUP54 gene Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Indicus|evm.model.CM009519.1.611 Q3ZBH3 CD151_BOVIN 99.605 0.992126 1.00395 CD151 - CD151 antigen - Bos taurus (Bovine) - CD151 gene Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Indicus|evm.model.CM009519.1.612 Q80ZJ8 EFC4A_MOUSE 65.054 0.916667 0.883249 Cracr2b - EF-hand calcium-binding domain-containing protein 4A - Mus musculus (Mouse) - Cracr2b gene Plays a role in store-operated Ca(2+) entry (SOCE). Indicus|evm.model.CM009519.1.613 Q2KI18 PLPL2_BOVIN 99.588 0.995893 1.00206 PNPLA2 - Patatin-like phospholipase domain-containing protein 2 - Bos taurus (Bovine) - PNPLA2 gene Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone. Also has acylglycerol transacylase activity. Acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides. Regulates adiposome size and may be involved in the degradation of adiposomes (By similarity). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). Indicus|evm.model.CM009519.1.614 O88450 DEAF1_RAT 86.916 0.981481 0.19115 Deaf1 - Deformed epidermal autoregulatory factor 1 homolog - Rattus norvegicus (Rat) - Deaf1 gene Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Transcriptional activator of EIF4G3. May also involved in behavior (By similarity). Indicus|evm.model.CM009519.1.615 P42899 RLA2_BOVIN 100.000 0.982759 1.0087 RPLP2 - 60S acidic ribosomal protein P2 - Bos taurus (Bovine) - RPLP2 gene Plays an important role in the elongation step of protein synthesis. Indicus|evm.model.CM009519.1.616 Q9HB75 PIDD1_HUMAN 82.037 0.997812 1.0044 PIDD1 - p53-induced death domain-containing protein 1 - Homo sapiens (Human) - PIDD1 gene Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:17159900). Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900). Indicus|evm.model.CM009519.1.617 P63298 SECR_PIG 100.000 0.508197 0.455224 SCT - Secretin precursor - Sus scrofa (Pig) - SCT gene Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity). Indicus|evm.model.CM009519.1.620 Q08DK4 GHC1_BOVIN 100.000 0.993808 1.00311 SLC25A22 - Mitochondrial glutamate carrier 1 - Bos taurus (Bovine) - SLC25A22 gene Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+) (By similarity). Indicus|evm.model.CM009519.1.621 Q29026 CEND_PIG 79.592 0.986395 1.05 CEND1 - Cell cycle exit and neuronal differentiation protein 1 - Sus scrofa (Pig) - CEND1 gene Involved in neuronal differentiation. Indicus|evm.model.CM009519.1.622 Q29RZ1 GALD1_BOVIN 99.497 0.673469 1.33636 GATD1 - Glutamine amidotransferase-like class 1 domain-containing protein 1 precursor - Bos taurus (Bovine) - GATD1 gene Indicus|evm.model.CM009519.1.623 Q2TBL6 TALDO_BOVIN 98.940 0.992958 0.84273 TALDO1 - Transaldolase - Bos taurus (Bovine) - TALDO1 gene Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Indicus|evm.model.CM009519.1.624 Q5RC07 ES8L2_PONAB 82.192 0.605042 0.166201 EPS8L2 - Epidermal growth factor receptor kinase substrate 8-like protein 2 - Pongo abelii (Sumatran orangutan) - EPS8L2 gene Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). Indicus|evm.model.CM009519.1.625 Q13202 DUS8_HUMAN 96.154 0.175048 1.6544 DUSP8 - Dual specificity protein phosphatase 8 - Homo sapiens (Human) - DUSP8 gene Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues. Indicus|evm.model.CM009519.1.626 Q92985 IRF7_HUMAN 62.264 0.995842 0.956262 IRF7 - Interferon regulatory factor 7 - Homo sapiens (Human) - IRF7 gene Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045). Indicus|evm.model.CM009519.1.627 Q99590 SCAFB_HUMAN 65.432 0.0487508 1.12167 SCAF11 - Protein SCAF11 - Homo sapiens (Human) - SCAF11 gene Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. Indicus|evm.model.CM009519.1.628 Q5RC07 ES8L2_PONAB 86.462 0.731126 1.05447 EPS8L2 - Epidermal growth factor receptor kinase substrate 8-like protein 2 - Pongo abelii (Sumatran orangutan) - EPS8L2 gene Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). Indicus|evm.model.CM009519.1.629 A1A4P6 TMM80_BOVIN 99.301 0.986111 1.00699 TMEM80 - Transmembrane protein 80 - Bos taurus (Bovine) - TMEM80 gene ciliary transition zone, non-motile cilium assembly Indicus|evm.model.CM009519.1.630 O88450 DEAF1_RAT 93.750 0.763838 0.479646 Deaf1 - Deformed epidermal autoregulatory factor 1 homolog - Rattus norvegicus (Rat) - Deaf1 gene Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Transcriptional activator of EIF4G3. May also involved in behavior (By similarity). Indicus|evm.model.CM009519.1.631 Q8IWQ3 BRSK2_HUMAN 94.453 0.965217 0.9375 BRSK2 - Serine/threonine-protein kinase BRSK2 - Homo sapiens (Human) - BRSK2 gene Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. Indicus|evm.model.CM009519.1.632 Q8IXW0 LMTD2_HUMAN 54.459 0.929878 0.51735 LMNTD2 - Lamin tail domain-containing protein 2 - Homo sapiens (Human) - LMNTD2 gene Indicus|evm.model.CM009519.1.633 Q8IYG6 LRC56_HUMAN 68.846 0.957328 0.994465 LRRC56 - Leucine-rich repeat-containing protein 56 - Homo sapiens (Human) - LRRC56 gene Required for the assembly of dynein arms. Indicus|evm.model.CM009519.1.634 P20171 RASH_RAT 95.767 0.989474 1.00529 Hras - GTPase HRas precursor - Rattus norvegicus (Rat) - Hras gene Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Indicus|evm.model.CM009519.1.635 Q9Z1X2 PTSS2_MOUSE 97.768 0.44334 1.06342 Ptdss2 - Phosphatidylserine synthase 2 - Mus musculus (Mouse) - Ptdss2 gene Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:10432300, PubMed:10938271, PubMed:23071296, PubMed:12361952). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:10938271, PubMed:23071296). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (PubMed:23071296). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (PubMed:23071296). Indicus|evm.model.CM009519.1.636 O08888 PTSS2_CRIGR 80.000 0.892562 0.255274 PTDSS2 - Phosphatidylserine synthase 2 - Cricetulus griseus (Chinese hamster) - PTDSS2 gene Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:12912985, PubMed:9235902). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:12912985, PubMed:9235902). Shows a substrate specificity for phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity). Indicus|evm.model.CM009519.1.637 Q6IA17 SIGIR_HUMAN 83.902 0.410231 2.43171 SIGIRR - Single Ig IL-1-related receptor - Homo sapiens (Human) - SIGIRR gene Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. Indicus|evm.model.CM009519.1.638 Q08DQ0 PKP3_BOVIN 99.874 0.997481 1.00126 PKP3 - Plakophilin-3 - Bos taurus (Bovine) - PKP3 gene May play a role in junctional plaques. Indicus|evm.model.CM009519.1.639 Q76KP1 B4GN4_HUMAN 89.227 0.609756 0.670837 B4GALNT4 - N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 - Homo sapiens (Human) - B4GALNT4 gene Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Indicus|evm.model.CM009519.1.640 Q2LGB5 TOLIP_BOVIN 100.000 0.992701 1.00366 TOLLIP - Toll-interacting protein - Bos taurus (Bovine) - TOLLIP gene Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). Indicus|evm.model.CM009519.1.641 Q76KP1 B4GN4_HUMAN 79.730 0.602459 0.234841 B4GALNT4 - N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 - Homo sapiens (Human) - B4GALNT4 gene Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Indicus|evm.model.CM009519.1.642 C9JQL5 DSA2D_HUMAN 70.370 0.727891 1.10526 Putative dispanin subfamily A member 2d - Homo sapiens (Human) Indicus|evm.model.CM009519.1.643 Q9HC84 MUC5B_HUMAN 65.919 0.901774 0.127213 MUC5B - Mucin-5B precursor - Homo sapiens (Human) - MUC5B gene Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Indicus|evm.model.CM009519.1.645 Q9HC84 MUC5B_HUMAN 71.950 0.385895 0.698889 MUC5B - Mucin-5B precursor - Homo sapiens (Human) - MUC5B gene Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Indicus|evm.model.CM009519.1.646 P98088 MUC5A_HUMAN 71.024 0.388165 0.651574 MUC5AC - Mucin-5AC precursor - Homo sapiens (Human) - MUC5AC gene Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). Indicus|evm.model.CM009519.1.648 Q02817 MUC2_HUMAN 68.966 0.904 0.0241359 MUC2 - Mucin-2 precursor - Homo sapiens (Human) - MUC2 gene Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. Indicus|evm.model.CM009520.1.1 Q8BHN1 TXLNG_MOUSE 94.118 0.706806 0.364504 Txlng - Gamma-taxilin - Mus musculus (Mouse) - Txlng gene May be involved in intracellular vesicle traffic (By similarity). Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. Indicus|evm.model.CM009520.1.2 Q8NDT2 RB15B_HUMAN 76.577 0.846154 0.146067 RBM15B - Putative RNA-binding protein 15B - Homo sapiens (Human) - RBM15B gene RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). Indicus|evm.model.CM009520.1.3 Q9UN76 S6A14_HUMAN 86.470 0.99688 0.998442 SLC6A14 - Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) - Homo sapiens (Human) - SLC6A14 gene Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner. Indicus|evm.model.CM009520.1.4 Q28929 AGTR2_SHEEP 98.077 0.713499 1.39615 AGTR2 - Type-2 angiotensin II receptor - Ovis aries (Sheep) - AGTR2 gene Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (By similarity). Indicus|evm.model.CM009520.1.7 Q9C0H6 KLHL4_HUMAN 77.857 0.978723 0.196379 KLHL4 - Kelch-like protein 4 - Homo sapiens (Human) - KLHL4 gene centriolar satellite, cytoplasm, microtubule cytoskeleton Indicus|evm.model.CM009520.1.8 Q9C0H6 KLHL4_HUMAN 92.629 0.994036 0.700557 KLHL4 - Kelch-like protein 4 - Homo sapiens (Human) - KLHL4 gene centriolar satellite, cytoplasm, microtubule cytoskeleton Indicus|evm.model.CM009520.1.9 Q9H6F5 CCD86_HUMAN 78.947 0.629213 0.247222 CCDC86 - Coiled-coil domain-containing protein 86 - Homo sapiens (Human) - CCDC86 gene chromosome, nucleolus, nucleoplasm, nucleus, RNA binding Indicus|evm.model.CM009520.1.10 A6QQY2 KLH13_BOVIN 100.000 0.935241 1.01374 KLHL13 - Kelch-like protein 13 - Bos taurus (Bovine) - KLHL13 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity). Indicus|evm.model.CM009520.1.12 P20821 GCSH_BOVIN 93.258 0.752137 0.676301 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Indicus|evm.model.CM009520.1.13 Q3T013 BNI3L_BOVIN 95.122 0.205128 0.890411 BNIP3L - BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like - Bos taurus (Bovine) - BNIP3L gene Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity). Indicus|evm.model.CM009520.1.14 Q9XSC3 WDR44_BOVIN 97.478 0.997768 0.982456 WDR44 - WD repeat-containing protein 44 - Bos taurus (Bovine) - WDR44 gene Downstream effector for RAB11. May be involved in vesicle recycling. Indicus|evm.model.CM009520.1.15 Q5JSL3 DOC11_HUMAN 97.059 0.999036 1.00096 DOCK11 - Dedicator of cytokinesis protein 11 - Homo sapiens (Human) - DOCK11 gene Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. Indicus|evm.model.CM009520.1.16 Q9BZ29 DOCK9_HUMAN 57.895 0.116525 0.22813 DOCK9 - Dedicator of cytokinesis protein 9 - Homo sapiens (Human) - DOCK9 gene Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. Indicus|evm.model.CM009520.1.17 Q96BY6 DOC10_HUMAN 68.794 0.313063 0.203111 DOCK10 - Dedicator of cytokinesis protein 10 - Homo sapiens (Human) - DOCK10 gene Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. Indicus|evm.model.CM009520.1.18 Q5JSL3 DOC11_HUMAN 88.889 0.985294 0.0656054 DOCK11 - Dedicator of cytokinesis protein 11 - Homo sapiens (Human) - DOCK11 gene Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. Indicus|evm.model.CM009520.1.19 P78552 I13R1_HUMAN 76.818 0.802198 0.639344 IL13RA1 - Interleukin-13 receptor subunit alpha-1 precursor - Homo sapiens (Human) - IL13RA1 gene Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. Indicus|evm.model.CM009520.1.20 Q08DL1 ZCH12_BOVIN 99.747 0.994949 0.985075 ZCCHC12 - Zinc finger CCHC domain-containing protein 12 - Bos taurus (Bovine) - ZCCHC12 gene Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity). Indicus|evm.model.CM009520.1.21 Q496Y0 LONF3_HUMAN 87.237 0.997368 1.00132 LONRF3 - LON peptidase N-terminal domain and RING finger protein 3 - Homo sapiens (Human) - LONRF3 gene Indicus|evm.model.CM009520.1.24 Q17QC0 PGRC1_BOVIN 99.485 0.989744 1.00515 PGRMC1 - Membrane-associated progesterone receptor component 1 - Bos taurus (Bovine) - PGRMC1 gene Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Indicus|evm.model.CM009520.1.25 A2A3V1 AK17B_MOUSE 60.104 0.997821 0.957247 Akap17b - A-kinase anchor protein 17B - Mus musculus (Mouse) - Akap17b gene Splice factor regulating alternative splice site selection for certain mRNA precursors. Indicus|evm.model.CM009520.1.26 Q96I51 RCC1L_HUMAN 83.019 0.641975 0.174569 RCC1L - RCC1-like G exchanging factor-like protein precursor - Homo sapiens (Human) - RCC1L gene Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (PubMed:27667664). Indicus|evm.model.CM009520.1.27 Q8NDT2 RB15B_HUMAN 95.455 0.784946 0.313483 RBM15B - Putative RNA-binding protein 15B - Homo sapiens (Human) - RBM15B gene RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). Indicus|evm.model.CM009520.1.28 P30742 RS26_CRICR 55.446 0.898876 0.773913 RPS26 - 40S ribosomal protein S26 - Cricetus cricetus (Black-bellied hamster) - RPS26 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, cytoplasmic translation Indicus|evm.model.CM009520.1.29 Q8WUT9 S2543_HUMAN 88.703 0.788194 0.844575 SLC25A43 - Solute carrier family 25 member 43 - Homo sapiens (Human) - SLC25A43 gene Indicus|evm.model.CM009520.1.30 Q8SQH5 ADT2_BOVIN 100.000 0.993311 1.00336 SLC25A5 - ADP/ATP translocase 2 - Bos taurus (Bovine) - SLC25A5 gene ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Probably mediates mitochondrial uncoupling in tissues that do not express UCP1. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). Indicus|evm.model.CM009520.1.31 Q3T197 STEEP_BOVIN 100.000 0.991031 1.0045 STEEP1 - STING ER exit protein - Bos taurus (Bovine) - STEEP1 gene Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (By similarity). Indicus|evm.model.CM009520.1.32 Q9Z255 UBE2A_MOUSE 100.000 0.986928 1.00658 Ube2a - Ubiquitin-conjugating enzyme E2 A - Mus musculus (Mouse) - Ube2a gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Indicus|evm.model.CM009520.1.33 O15226 NKRF_HUMAN 96.522 0.877707 1.13768 NKRF - NF-kappa-B-repressing factor - Homo sapiens (Human) - NKRF gene Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. Indicus|evm.model.CM009520.1.34 Q3SZN0 SEPT6_BOVIN 100.000 0.925831 0.915691 SEPTIN6 - Septin-6 - Bos taurus (Bovine) - SEPTIN6 gene Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Indicus|evm.model.CM009520.1.36 A6NJG2 SWAHD_HUMAN 73.913 0.993769 1.01905 SOWAHD - Ankyrin repeat domain-containing protein SOWAHD - Homo sapiens (Human) - SOWAHD gene Indicus|evm.model.CM009520.1.37 Q5R9C3 GPBL1_PONAB 88.095 0.878947 0.400844 GPBP1L1 - Vasculin-like protein 1 - Pongo abelii (Sumatran orangutan) - GPBP1L1 gene Possible transcription factor. Indicus|evm.model.CM009520.1.38 Q9BZI7 REN3B_HUMAN 92.754 0.995754 0.975155 UPF3B - Regulator of nonsense transcripts 3B - Homo sapiens (Human) - UPF3B gene Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. Indicus|evm.model.CM009520.1.40 Q91XL9 OSBL1_MOUSE 89.644 0.993548 0.326316 Osbpl1a - Oxysterol-binding protein-related protein 1 - Mus musculus (Mouse) - Osbpl1a gene Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol. Indicus|evm.model.CM009520.1.41 Q67ER4 R113A_BOVIN 99.708 0.753304 1.32362 RNF113A - E3 ubiquitin-protein ligase RNF113A - Bos taurus (Bovine) - RNF113A gene Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. Indicus|evm.model.CM009520.1.42 O35817 AKA14_RAT 58.553 0.557196 0.539841 Akap14 - A-kinase anchor protein 14 - Rattus norvegicus (Rat) - Akap14 gene Binds to type II regulatory subunits of protein kinase A and anchors/targets them. Indicus|evm.model.CM009520.1.43 Q9D0F4 NKAP_MOUSE 91.847 0.995215 1.00723 Nkap - NF-kappa-B-activating protein - Mus musculus (Mouse) - Nkap gene Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity). Indicus|evm.model.CM009520.1.45 O42115 ARX_DANRE 55.882 0.338384 0.437086 arx - Aristaless-related homeobox protein - Danio rerio (Zebrafish) - arx gene Appears to be indispensable for the central nervous system development. May have a role in the neuronal differentiation of the ganglionic eminence and ventral thalamus. May also be involved in axonal guidance in the floor plate. Indicus|evm.model.CM009520.1.51 Q3SX46 C1GLC_BOVIN 99.686 0.99373 1.00314 C1GALT1C1 - C1GALT1-specific chaperone 1 - Bos taurus (Bovine) - C1GALT1C1 gene Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity). Indicus|evm.model.CM009520.1.52 Q4G009 MCTS1_RAT 99.451 0.989071 1.00549 Mcts1 - Malignant T-cell-amplified sequence 1 - Rattus norvegicus (Rat) - Mcts1 gene Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3 (By similarity). Indicus|evm.model.CM009520.1.54 Q13620 CUL4B_HUMAN 96.233 0.997847 1.01752 CUL4B - Cullin-4B - Homo sapiens (Human) - CUL4B gene Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). Indicus|evm.model.CM009520.1.55 P13473 LAMP2_HUMAN 74.939 0.990196 0.995122 LAMP2 - Lysosome-associated membrane glycoprotein 2 precursor - Homo sapiens (Human) - LAMP2 gene Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820). Indicus|evm.model.CM009520.1.56 A0A0J9YY54 TX13D_HUMAN 45.183 0.867069 0.463585 TEX13D - Testis-expressed protein 13D - Homo sapiens (Human) - TEX13D gene Indicus|evm.model.CM009520.1.57 A7MB71 AT1B4_BOVIN 100.000 0.974504 0.994366 ATP1B4 - Protein ATP1B4 - Bos taurus (Bovine) - ATP1B4 gene May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity). Indicus|evm.model.CM009520.1.58 Q5JRV8 T255A_HUMAN 91.404 0.993865 0.934097 TMEM255A - Transmembrane protein 255A - Homo sapiens (Human) - TMEM255A gene Indicus|evm.model.CM009520.1.59 Q86T24 KAISO_HUMAN 92.560 0.996997 0.991071 ZBTB33 - Transcriptional regulator Kaiso - Homo sapiens (Human) - ZBTB33 gene Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). Indicus|evm.model.CM009520.1.61 A6NNA5 DRGX_HUMAN 52.381 0.200647 1.1749 DRGX - Dorsal root ganglia homeobox protein - Homo sapiens (Human) - DRGX gene Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. Indicus|evm.model.CM009520.1.62 Q32KN9 PRLD1_BOVIN 57.983 0.898876 0.406393 PRELID1 - PRELI domain-containing protein 1, mitochondrial precursor - Bos taurus (Bovine) - PRELID1 gene Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs (By similarity). Indicus|evm.model.CM009520.1.64 Q9Z2W9 GRIA3_MOUSE 99.132 0.982906 0.922297 Gria3 - Glutamate receptor 3 precursor - Mus musculus (Mouse) - Gria3 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Indicus|evm.model.CM009520.1.65 B2KI97 THOC2_RHIFE 98.717 0.972534 1.0165 THOC2 - THO complex subunit 2 - Rhinolophus ferrumequinum (Greater horseshoe bat) - THOC2 gene Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Plays a role for proper neuronal development. Indicus|evm.model.CM009520.1.66 P98170 XIAP_HUMAN 87.726 0.995984 1.00201 XIAP - E3 ubiquitin-protein ligase XIAP - Homo sapiens (Human) - XIAP gene Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program. Indicus|evm.model.CM009520.1.67 Q8N3U4 STAG2_HUMAN 96.845 0.998424 1.03087 STAG2 - Cohesin subunit SA-2 - Homo sapiens (Human) - STAG2 gene Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Indicus|evm.model.CM009520.1.68 P79103 RS4_BOVIN 91.250 0.868852 0.695817 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009520.1.69 Q8IYD1 ERF3B_HUMAN 96.659 0.995556 0.716561 GSPT2 - Eukaryotic peptide chain release factor GTP-binding subunit ERF3B - Homo sapiens (Human) - GSPT2 gene Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Indicus|evm.model.CM009520.1.70 Q5R4B3 ERF3B_PONAB 61.321 0.628743 0.265924 GSPT2 - Eukaryotic peptide chain release factor GTP-binding subunit ERF3B - Pongo abelii (Sumatran orangutan) - GSPT2 gene Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Indicus|evm.model.CM009520.1.71 Q3ZBB1 SH21A_BOVIN 99.219 0.436426 2.27344 SH2D1A - SH2 domain-containing protein 1A - Bos taurus (Bovine) - SH2D1A gene Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (By similarity). Indicus|evm.model.CM009520.1.72 Q9UKZ4 TEN1_HUMAN 97.038 0.957212 0.763303 TENM1 - Teneurin-1 - Homo sapiens (Human) - TENM1 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). Indicus|evm.model.CM009520.1.74 Q3SZQ6 RL32_BOVIN 60.741 0.89916 0.881481 RPL32 - 60S ribosomal protein L32 - Bos taurus (Bovine) - RPL32 gene cytosolic large ribosomal subunit Indicus|evm.model.CM009520.1.75 Q9WTS4 TEN1_MOUSE 96.552 0.623188 0.0505309 Tenm1 - Teneurin-1 - Mus musculus (Mouse) - Tenm1 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). Indicus|evm.model.CM009520.1.77 P23196 APEX1_BOVIN 91.623 0.964467 0.619497 APEX1 - DNA-(apurinic or apyrimidinic site) endonuclease - Bos taurus (Bovine) - APEX1 gene Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA (By similarity). Indicus|evm.model.CM009520.1.78 A0A0J9YWL9 TX13C_HUMAN 45.681 0.901857 0.759315 TEX13C - Putative testis-expressed protein 13C - Homo sapiens (Human) - TEX13C gene Indicus|evm.model.CM009520.1.81 Q9AT35 RL23A_DAUCA 68.539 0.745763 0.766234 RPL23A - 60S ribosomal protein L23a - Daucus carota (Wild carrot) - RPL23A gene This protein binds to a specific region on the 26S rRNA. Indicus|evm.model.CM009520.1.82 Q5VW00 DC122_HUMAN 86.301 0.982022 0.961123 DCAF12L2 - DDB1- and CUL4-associated factor 12-like protein 2 - Homo sapiens (Human) - DCAF12L2 gene Cul4-RING E3 ubiquitin ligase complex Indicus|evm.model.CM009520.1.83 Q5VW00 DC122_HUMAN 75.359 0.99284 0.904968 DCAF12L2 - DDB1- and CUL4-associated factor 12-like protein 2 - Homo sapiens (Human) - DCAF12L2 gene Cul4-RING E3 ubiquitin ligase complex Indicus|evm.model.CM009520.1.84 Q5VW00 DC122_HUMAN 73.846 0.215 1.2959 DCAF12L2 - DDB1- and CUL4-associated factor 12-like protein 2 - Homo sapiens (Human) - DCAF12L2 gene Cul4-RING E3 ubiquitin ligase complex Indicus|evm.model.CM009520.1.85 Q5VW00 DC122_HUMAN 76.256 0.990909 0.475162 DCAF12L2 - DDB1- and CUL4-associated factor 12-like protein 2 - Homo sapiens (Human) - DCAF12L2 gene Cul4-RING E3 ubiquitin ligase complex Indicus|evm.model.CM009520.1.86 Q5JUK9 PAGE3_HUMAN 46.237 0.793103 1.02655 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Indicus|evm.model.CM009520.1.88 O43422 P52K_HUMAN 94.203 0.312785 0.575558 THAP12 - 52 kDa repressor of the inhibitor of the protein kinase - Homo sapiens (Human) - THAP12 gene Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. Indicus|evm.model.CM009520.1.91 A5PJK7 PRR32_BOVIN 99.640 0.992832 0.945763 PRR32 - Proline-rich protein 32 - Bos taurus (Bovine) - PRR32 gene Indicus|evm.model.CM009520.1.92 P02793 FRIL1_RAT 70.968 0.968254 0.344262 Ftl1 - Ferritin light chain 1 - Rattus norvegicus (Rat) - Ftl1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.94 Q8IU81 I2BP1_HUMAN 96.786 0.925497 1.03425 IRF2BP1 - Interferon regulatory factor 2-binding protein 1 - Homo sapiens (Human) - IRF2BP1 gene Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. Indicus|evm.model.CM009520.1.95 Q8TDG2 ACTT1_HUMAN 80.371 0.994709 1.00532 ACTRT1 - Actin-related protein T1 - Homo sapiens (Human) - ACTRT1 gene Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Indicus|evm.model.CM009520.1.97 P28370 SMCA1_HUMAN 97.429 0.976723 1.01898 SMARCA1 - Probable global transcription activator SNF2L1 - Homo sapiens (Human) - SMARCA1 gene Energy-transducing component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells. Indicus|evm.model.CM009520.1.98 Q01968 OCRL_HUMAN 94.570 0.99774 0.982242 OCRL - Inositol polyphosphate 5-phosphatase OCRL - Homo sapiens (Human) - OCRL gene Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:7761412, PubMed:15474001, PubMed:9430698, PubMed:10764818). Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:7761412, PubMed:25869668). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788). Indicus|evm.model.CM009520.1.99 Q9TUI9 APEL_BOVIN 100.000 0.963636 0.714286 APLN - Apelin precursor - Bos taurus (Bovine) - APLN gene Endogenous ligand for the apelin receptor (APLNR) (PubMed:9792798). Drives internalization of APLNR (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity). Indicus|evm.model.CM009520.1.100 Q95333 XPP2_PIG 87.221 0.997033 1.00149 XPNPEP2 - Xaa-Pro aminopeptidase 2 precursor - Sus scrofa (Pig) - XPNPEP2 gene Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin. Indicus|evm.model.CM009520.1.101 E9PRG8 CK098_HUMAN 83.740 0.983871 1.00813 C11orf98 - Uncharacterized protein C11orf98 - Homo sapiens (Human) - C11orf98 gene Indicus|evm.model.CM009520.1.102 A0JN71 SASH3_BOVIN 92.526 0.994859 1.02368 SASH3 - SAM and SH3 domain-containing protein 3 - Bos taurus (Bovine) - SASH3 gene May function as a signaling adapter protein in lymphocytes. Indicus|evm.model.CM009520.1.103 Q58DA8 ZDHC9_BOVIN 97.844 0.994624 1.02479 ZDHHC9 - Palmitoyltransferase ZDHHC9 - Bos taurus (Bovine) - ZDHHC9 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. Indicus|evm.model.CM009520.1.104 Q8BXX9 CC169_MOUSE 68.692 0.990654 1 Ccdc169 - Coiled-coil domain-containing protein 169 - Mus musculus (Mouse) - Ccdc169 gene Indicus|evm.model.CM009520.1.105 Q3T0Q8 UT14A_BOVIN 99.870 0.997406 1.0013 UTP14A - U3 small nucleolar RNA-associated protein 14 homolog A - Bos taurus (Bovine) - UTP14A gene May be required for ribosome biogenesis. Indicus|evm.model.CM009520.1.106 Q5H9F3 BCORL_HUMAN 88.755 0.13822 1.04442 BCORL1 - BCL-6 corepressor-like protein 1 - Homo sapiens (Human) - BCORL1 gene Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Indicus|evm.model.CM009520.1.107 Q99607 ELF4_HUMAN 87.822 0.9509 0.921569 ELF4 - ETS-related transcription factor Elf-4 - Homo sapiens (Human) - ELF4 gene Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Indicus|evm.model.CM009520.1.108 O95831 AIFM1_HUMAN 94.127 0.996743 1.00163 AIFM1 - Apoptosis-inducing factor 1, mitochondrial precursor - Homo sapiens (Human) - AIFM1 gene Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:20362274, PubMed:23217327, PubMed:17094969). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (By similarity). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). Indicus|evm.model.CM009520.1.109 Q14088 RB33A_HUMAN 99.578 0.991597 1.00422 RAB33A - Ras-related protein Rab-33A - Homo sapiens (Human) - RAB33A gene endosome, Golgi apparatus, Golgi membrane, GTPase activity, antigen processing and presentation Indicus|evm.model.CM009520.1.110 Q8ND82 Z280C_HUMAN 65.199 0.964335 0.989145 ZNF280C - Zinc finger protein 280C - Homo sapiens (Human) - ZNF280C gene May function as a transcription factor. Indicus|evm.model.CM009520.1.111 O95258 UCP5_HUMAN 98.000 0.866667 1.06154 SLC25A14 - Brain mitochondrial carrier protein 1 - Homo sapiens (Human) - SLC25A14 gene Participates in the mitochondrial proton leak measured in brain mitochondria. Indicus|evm.model.CM009520.1.112 Q7TQN8 GP119_RAT 79.461 0.880952 0.717949 Gpr119 - Glucose-dependent insulinotropic receptor - Rattus norvegicus (Rat) - Gpr119 gene Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. Indicus|evm.model.CM009520.1.113 Q9Y388 RBMX2_HUMAN 88.387 0.762376 0.627329 RBMX2 - RNA-binding motif protein, X-linked 2 - Homo sapiens (Human) - RBMX2 gene Involved in pre-mRNA splicing as component of the activated spliceosome. Indicus|evm.model.CM009520.1.115 Q5CZC0 FSIP2_HUMAN 54.265 0.993418 0.923845 FSIP2 - Fibrous sheath-interacting protein 2 - Homo sapiens (Human) - FSIP2 gene Plays a role in spermatogenesis. Indicus|evm.model.CM009520.1.116 A2ARZ3 FSIP2_MOUSE 51.707 0.884026 0.0653324 Fsip2 - Fibrous sheath-interacting protein 2 - Mus musculus (Mouse) - Fsip2 gene Plays a role in spermatogenesis. Indicus|evm.model.CM009520.1.117 Q16206 ENOX2_HUMAN 95.610 0.894737 0.37377 ENOX2 - Ecto-NOX disulfide-thiol exchanger 2 - Homo sapiens (Human) - ENOX2 gene May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. Indicus|evm.model.CM009520.1.118 Q16206 ENOX2_HUMAN 100.000 0.734637 0.586885 ENOX2 - Ecto-NOX disulfide-thiol exchanger 2 - Homo sapiens (Human) - ENOX2 gene May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. Indicus|evm.model.CM009520.1.120 A7MB27 RHG36_BOVIN 100.000 0.0464253 2.03208 ARHGAP36 - Rho GTPase-activating protein 36 precursor - Bos taurus (Bovine) - ARHGAP36 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009520.1.122 Q8N6C5 IGSF1_HUMAN 88.459 0.873258 1.12799 IGSF1 - Immunoglobulin superfamily member 1 precursor - Homo sapiens (Human) - IGSF1 gene Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription. Indicus|evm.model.CM009520.1.123 P0C5Z0 H2AB2_HUMAN 68.817 0.538012 1.48696 H2AB2 - Histone H2A-Bbd type 2/3 - Homo sapiens (Human) - H2AB2 gene Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis. Indicus|evm.model.CM009520.1.124 Q9H207 O10A5_HUMAN 53.103 0.922581 0.488959 OR10A5 - Olfactory receptor 10A5 - Homo sapiens (Human) - OR10A5 gene Odorant receptor (Potential). May be involved in taste perception. Indicus|evm.model.CM009520.1.129 Q9P289 STK26_HUMAN 99.038 0.995204 1.0024 STK26 - Serine/threonine-protein kinase 26 - Homo sapiens (Human) - STK26 gene Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Indicus|evm.model.CM009520.1.130 Q6ZUT3 FRMD7_HUMAN 87.903 0.940729 0.921569 FRMD7 - FERM domain-containing protein 7 - Homo sapiens (Human) - FRMD7 gene Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. Indicus|evm.model.CM009520.1.131 Q8BU31 RAP2C_MOUSE 100.000 0.98913 1.00546 Rap2c - Ras-related protein Rap-2c precursor - Mus musculus (Mouse) - Rap2c gene Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. Indicus|evm.model.CM009520.1.132 Q9NUK0 MBNL3_HUMAN 82.173 0.994444 1.01695 MBNL3 - Muscleblind-like protein 3 - Homo sapiens (Human) - MBNL3 gene Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. Indicus|evm.model.CM009520.1.133 Q96MM7 H6ST2_HUMAN 89.298 0.780105 0.631405 HS6ST2 - Heparan-sulfate 6-O-sulfotransferase 2 - Homo sapiens (Human) - HS6ST2 gene 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Indicus|evm.model.CM009520.1.138 Q80UW0 H6ST2_MOUSE 87.931 0.798595 0.697712 Hs6st2 - Heparan-sulfate 6-O-sulfotransferase 2 - Mus musculus (Mouse) - Hs6st2 gene 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Indicus|evm.model.CM009520.1.139 Q99MX1 UBP26_MOUSE 53.012 0.0914158 1.07425 Usp26 - Ubiquitin carboxyl-terminal hydrolase 26 - Mus musculus (Mouse) - Usp26 gene Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway. Indicus|evm.model.CM009520.1.140 Q5R6X7 CBX3_PONAB 52.101 0.939024 0.448087 CBX3 - Chromobox protein homolog 3 - Pongo abelii (Sumatran orangutan) - CBX3 gene Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). Indicus|evm.model.CM009520.1.142 O75487 GPC4_HUMAN 93.525 0.996409 1.0018 GPC4 - Glypican-4 precursor - Homo sapiens (Human) - GPC4 gene Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). Indicus|evm.model.CM009520.1.143 A5A6P7 GPC3_PANTR 95.522 0.975 0.827586 GPC3 - Glypican-3 precursor - Pan troglodytes (Chimpanzee) - GPC3 gene Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity). Indicus|evm.model.CM009520.1.145 O46415 FRIL_BOVIN 94.382 0.619718 0.811429 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.146 O46415 FRIL_BOVIN 93.671 0.975 0.457143 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.148 Q2T9U9 CC160_BOVIN 100.000 0.993827 1.0031 CCDC160 - Coiled-coil domain-containing protein 160 - Bos taurus (Bovine) - CCDC160 gene Indicus|evm.model.CM009520.1.149 Q08DR0 PHF6_BOVIN 83.481 0.994065 0.923288 PHF6 - PHD finger protein 6 - Bos taurus (Bovine) - PHF6 gene Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. Indicus|evm.model.CM009520.1.150 Q3SZ18 HPRT_BOVIN 100.000 0.990868 1.00459 HPRT1 - Hypoxanthine-guanine phosphoribosyltransferase - Bos taurus (Bovine) - HPRT1 gene Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). Indicus|evm.model.CM009520.1.151 Q9HBJ0 PLAC1_HUMAN 70.391 0.988889 0.849057 PLAC1 - Placenta-specific protein 1 precursor - Homo sapiens (Human) - PLAC1 gene May play a role in placental development. Indicus|evm.model.CM009520.1.152 Q7Z309 PBIR2_HUMAN 86.802 0.875 0.906883 PABIR2 - PABIR family member 2 - Homo sapiens (Human) - PABIR2 gene Indicus|evm.model.CM009520.1.154 Q7Z309 PBIR2_HUMAN 55.385 0.447552 0.578947 PABIR2 - PABIR family member 2 - Homo sapiens (Human) - PABIR2 gene Indicus|evm.model.CM009520.1.155 Q2T9W7 MSPD1_BOVIN 100.000 0.990654 1.00469 MOSPD1 - Motile sperm domain-containing protein 1 - Bos taurus (Bovine) - MOSPD1 gene Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. Indicus|evm.model.CM009520.1.156 P0DMW5 SIL2B_HUMAN 90.741 0.284946 2.38462 SMIM10L2B - Small integral membrane protein 10-like protein 2B - Homo sapiens (Human) - SMIM10L2B gene Indicus|evm.model.CM009520.1.157 Q1JQ94 RTL8_BOVIN 100.000 0.982456 1.00885 RTL8A - Retrotransposon Gag-like protein 8 - Bos taurus (Bovine) - RTL8A gene nucleolus Indicus|evm.model.CM009520.1.159 Q1JQ94 RTL8_BOVIN 100.000 0.982456 1.00885 RTL8A - Retrotransposon Gag-like protein 8 - Bos taurus (Bovine) - RTL8A gene nucleolus Indicus|evm.model.CM009520.1.160 Q1JQ94 RTL8_BOVIN 73.529 0.423611 1.27434 RTL8A - Retrotransposon Gag-like protein 8 - Bos taurus (Bovine) - RTL8A gene nucleolus Indicus|evm.model.CM009520.1.162 Q1JQ94 RTL8_BOVIN 100.000 0.982456 1.00885 RTL8A - Retrotransposon Gag-like protein 8 - Bos taurus (Bovine) - RTL8A gene nucleolus Indicus|evm.model.CM009520.1.163 Q9BXT6 M10L1_HUMAN 57.430 0.987603 0.199835 MOV10L1 - RNA helicase Mov10l1 - Homo sapiens (Human) - MOV10L1 gene ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. Indicus|evm.model.CM009520.1.164 P0DMW5 SIL2B_HUMAN 94.828 0.53271 1.37179 SMIM10L2B - Small integral membrane protein 10-like protein 2B - Homo sapiens (Human) - SMIM10L2B gene Indicus|evm.model.CM009520.1.165 P51815 ZN75D_HUMAN 60.606 0.942529 0.682353 ZNF75D - Zinc finger protein 75D - Homo sapiens (Human) - ZNF75D gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.166 P51815 ZN75D_HUMAN 56.881 0.769784 0.272549 ZNF75D - Zinc finger protein 75D - Homo sapiens (Human) - ZNF75D gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.167 P51815 ZN75D_HUMAN 69.548 0.971264 1.02353 ZNF75D - Zinc finger protein 75D - Homo sapiens (Human) - ZNF75D gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.169 A2T6W2 ZN449_PANTR 91.715 0.996154 1.00386 ZNF449 - Zinc finger protein 449 - Pan troglodytes (Chimpanzee) - ZNF449 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.170 P51815 ZN75D_HUMAN 68.182 0.358333 0.235294 ZNF75D - Zinc finger protein 75D - Homo sapiens (Human) - ZNF75D gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.171 Q1LZ87 ZN397_BOVIN 64.634 0.503106 0.301498 ZNF397 - Zinc finger protein 397 - Bos taurus (Bovine) - ZNF397 gene DNA-dependent transcriptional repressor. Indicus|evm.model.CM009520.1.172 P51815 ZN75D_HUMAN 66.667 0.072695 1.10588 ZNF75D - Zinc finger protein 75D - Homo sapiens (Human) - ZNF75D gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.176 Q5RBN9 TAD2B_PONAB 87.678 0.995272 1.00714 TADA2B - Transcriptional adapter 2-beta - Pongo abelii (Sumatran orangutan) - TADA2B gene Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. Indicus|evm.model.CM009520.1.177 Q5JSJ4 INT6L_HUMAN 84.933 0.997655 0.990708 INTS6L - Integrator complex subunit 6-like - Homo sapiens (Human) - INTS6L gene integrator complex, snRNA 3'-end processing Indicus|evm.model.CM009520.1.178 Q9NXZ1 SAGE1_HUMAN 62.842 0.62116 0.324115 SAGE1 - Sarcoma antigen 1 - Homo sapiens (Human) - SAGE1 gene integrator complex, nuclear body, nucleoplasm, snRNA 3'-end processing Indicus|evm.model.CM009520.1.179 Q8N4V1 EMC5_HUMAN 99.237 0.984848 1.00763 MMGT1 - ER membrane protein complex subunit 5 - Homo sapiens (Human) - MMGT1 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (By similarity). May be involved in Mg(2+) transport (By similarity). Indicus|evm.model.CM009520.1.180 Q92581 SL9A6_HUMAN 90.833 0.997226 1.07773 SLC9A6 - Sodium/hydrogen exchanger 6 - Homo sapiens (Human) - SLC9A6 gene Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis. Indicus|evm.model.CM009520.1.181 Q9WUH4 FHL1_RAT 80.757 0.902857 1.25 Fhl1 - Four and a half LIM domains protein 1 - Rattus norvegicus (Rat) - Fhl1 gene May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems (By similarity). Indicus|evm.model.CM009520.1.182 Q96T17 MA7D2_HUMAN 63.462 0.047486 1.46721 MAP7D2 - MAP7 domain-containing protein 2 - Homo sapiens (Human) - MAP7D2 gene microtubule cytoskeleton, microtubule cytoskeleton organization Indicus|evm.model.CM009520.1.183 Q8IZF6 AGRG4_HUMAN 68.790 0.975 0.0519481 ADGRG4 - Adhesion G-protein coupled receptor G4 precursor - Homo sapiens (Human) - ADGRG4 gene Orphan receptor. Indicus|evm.model.CM009520.1.185 O97967 BRS3_SHEEP 96.992 0.995 1.00251 BRS3 - Bombesin receptor subtype-3 - Ovis aries (Sheep) - BRS3 gene Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Indicus|evm.model.CM009520.1.186 O43719 HTSF1_HUMAN 76.823 0.986996 1.01854 HTATSF1 - HIV Tat-specific factor 1 - Homo sapiens (Human) - HTATSF1 gene Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. Indicus|evm.model.CM009520.1.187 Q8N8G2 VGLL2_HUMAN 80.000 0.144105 0.722397 VGLL2 - Transcription cofactor vestigial-like protein 2 - Homo sapiens (Human) - VGLL2 gene May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles. Indicus|evm.model.CM009520.1.188 P51749 CD40L_BOVIN 100.000 0.992366 1.00383 CD40LG - CD40 ligand - Bos taurus (Bovine) - CD40LG gene Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Indicus|evm.model.CM009520.1.189 Q15052 ARHG6_HUMAN 94.588 0.967541 1.03222 ARHGEF6 - Rho guanine nucleotide exchange factor 6 - Homo sapiens (Human) - ARHGEF6 gene Acts as a RAC1 guanine nucleotide exchange factor (GEF). Indicus|evm.model.CM009520.1.190 A5A6M3 RBMX_PANTR 99.744 0.994898 1.00256 RBMX - RNA-binding motif protein, X chromosome - Pan troglodytes (Chimpanzee) - RBMX gene RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment (By similarity). Indicus|evm.model.CM009520.1.191 Q5R8Y6 TM9S2_PONAB 69.352 0.93994 1.00452 TM9SF2 - Transmembrane 9 superfamily member 2 precursor - Pongo abelii (Sumatran orangutan) - TM9SF2 gene In the intracellular compartments, may function as a channel or small molecule transporter. Indicus|evm.model.CM009520.1.192 Q96P66 GP101_HUMAN 85.156 0.996032 0.992126 GPR101 - Probable G-protein coupled receptor 101 - Homo sapiens (Human) - GPR101 gene Orphan receptor. Indicus|evm.model.CM009520.1.193 Q920A7 AFG31_MOUSE 71.429 0.574586 0.229404 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Indicus|evm.model.CM009520.1.194 O60481 ZIC3_HUMAN 84.950 0.778295 1.38116 ZIC3 - Zinc finger protein ZIC 3 - Homo sapiens (Human) - ZIC3 gene Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Indicus|evm.model.CM009520.1.195 Q63HM2 PCX4_HUMAN 87.597 0.680851 0.16041 PCNX4 - Pecanex-like protein 4 - Homo sapiens (Human) - PCNX4 gene Indicus|evm.model.CM009520.1.197 A6NCF6 MA13P_HUMAN 61.420 0.97561 0.961877 MAGEA13P - Putative MAGE domain-containing protein MAGEA13P - Homo sapiens (Human) - MAGEA13P gene Indicus|evm.model.CM009520.1.198 Q9ERW3 FGF13_RAT 100.000 0.623288 1.19184 Fgf13 - Fibroblast growth factor 13 - Rattus norvegicus (Rat) - Fgf13 gene Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity). Indicus|evm.model.CM009520.1.200 Q95LF0 I13R2_CANLF 79.202 0.811628 1.11399 IL13RA2 - Interleukin-13 receptor subunit alpha-2 precursor - Canis lupus familiaris (Dog) - IL13RA2 gene Binds as a monomer with high affinity to interleukin-13 (IL13). Indicus|evm.model.CM009520.1.201 Q5ZJQ7 SSU72_CHICK 61.856 0.782828 1.02062 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Gallus gallus (Chicken) - SSU72 gene May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination. Indicus|evm.model.CM009520.1.202 Q5ZJQ7 SSU72_CHICK 78.626 0.984496 0.664948 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Gallus gallus (Chicken) - SSU72 gene May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination. Indicus|evm.model.CM009520.1.203 P00741 FA9_BOVIN 100.000 0.99568 1.00216 F9 - Coagulation factor IX precursor - Bos taurus (Bovine) - F9 gene Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Indicus|evm.model.CM009520.1.204 P10911 MCF2_HUMAN 83.333 0.796217 1.2573 MCF2 - Proto-oncogene DBL - Homo sapiens (Human) - MCF2 gene Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42. Indicus|evm.model.CM009520.1.205 Q8NB49 AT11C_HUMAN 93.494 0.985062 1.0053 ATP11C - Phospholipid-transporting ATPase IG - Homo sapiens (Human) - ATP11C gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:32493773, PubMed:24904167, PubMed:26567335). Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:26944472). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity). Indicus|evm.model.CM009520.1.206 Q920A7 AFG31_MOUSE 82.381 0.863636 0.306717 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Indicus|evm.model.CM009520.1.207 P61959 SUMO2_RAT 98.947 0.979167 1.01053 Sumo2 - Small ubiquitin-related modifier 2 precursor - Rattus norvegicus (Rat) - Sumo2 gene Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). Indicus|evm.model.CM009520.1.209 Q2YDJ5 CX066_BOVIN 91.030 0.993174 0.811634 Uncharacterized protein CXorf66 homolog precursor - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.210 Q2YDJ5 CX066_BOVIN 97.230 0.994475 1.00277 Uncharacterized protein CXorf66 homolog precursor - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.211 Q14CZ0 CP072_HUMAN 65.657 0.860262 0.832727 C16orf72 - UPF0472 protein C16orf72 - Homo sapiens (Human) - C16orf72 gene Indicus|evm.model.CM009520.1.212 Q58D31 DHSO_BOVIN 62.500 0.858182 0.772472 SORD - Sorbitol dehydrogenase - Bos taurus (Bovine) - SORD gene Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with xylitol, D-sorbitol (D-glucitol) and L-iditol as substrates, leading to the C2-oxidized products D-xylulose, D-fructose and L-sorbose, respectively (PubMed:9143345). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). Cannot use NADP(+) as the electron acceptor. Has no activity on ethanol, methanol, glycerol, galactitol and fructose 6-phosphate (PubMed:9143345). Indicus|evm.model.CM009520.1.214 Q4R4Z6 RS3A_MACFA 90.226 0.745763 0.670455 RPS3A - 40S ribosomal protein S3a - Macaca fascicularis (Crab-eating macaque) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009520.1.216 Q17QF6 LDOC1_BOVIN 99.315 0.986395 1.00685 LDOC1 - Protein LDOC1 - Bos taurus (Bovine) - LDOC1 gene May have an important role in the development and/or progression of some cancers. Indicus|evm.model.CM009520.1.219 P43362 MAGA9_HUMAN 56.831 0.787879 0.733333 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.220 P43358 MAGA4_HUMAN 63.768 0.507463 0.422713 MAGEA4 - Melanoma-associated antigen 4 - Homo sapiens (Human) - MAGEA4 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.221 Q2YDJ5 CX066_BOVIN 68.045 0.992453 0.734072 Uncharacterized protein CXorf66 homolog precursor - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.224 Q8IW52 SLIK4_HUMAN 97.136 0.952164 1.04898 SLITRK4 - SLIT and NTRK-like protein 4 precursor - Homo sapiens (Human) - SLITRK4 gene It is involved in synaptogenesis and promotes synapse differentiation (PubMed:27812321). Suppresses neurite outgrowth (By similarity). Indicus|evm.model.CM009520.1.225 P62936 PPIA_PIG 75.490 0.971154 0.634146 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Indicus|evm.model.CM009520.1.226 A6NCF6 MA13P_HUMAN 57.317 0.958944 1 MAGEA13P - Putative MAGE domain-containing protein MAGEA13P - Homo sapiens (Human) - MAGEA13P gene Indicus|evm.model.CM009520.1.227 Q9H156 SLIK2_HUMAN 97.041 0.997633 1 SLITRK2 - SLIT and NTRK-like protein 2 precursor - Homo sapiens (Human) - SLITRK2 gene It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Suppresses neurite outgrowth (By similarity). Indicus|evm.model.CM009520.1.230 O97965 STP3_SHEEP 80.000 0.981982 1.00909 Spermatid nuclear transition protein 3 - Ovis aries (Sheep) Indicus|evm.model.CM009520.1.233 Q5R7F9 MA7D2_PONAB 75.667 0.873239 0.930537 MAP7D2 - MAP7 domain-containing protein 2 - Pongo abelii (Sumatran orangutan) - MAP7D2 gene Indicus|evm.model.CM009520.1.235 A2AJT9 BCLA3_HUMAN 72.168 0.997187 1 BCLAF3 - BCLAF1 and THRAP3 family member 3 - Homo sapiens (Human) - BCLAF3 gene mediator complex, DNA binding, transcription coregulator activity, positive regulation of transcription by RNA polymerase II Indicus|evm.model.CM009520.1.237 Q06787 FMR1_HUMAN 96.203 0.99684 1.00158 FMR1 - Synaptic functional regulator FMR1 - Homo sapiens (Human) - FMR1 gene Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs (PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Plays a role in mRNA nuclear export (By similarity). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postsynaptic dendritic spines (PubMed:11532944, PubMed:11157796, PubMed:12594214, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes (PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:14703574, PubMed:17057366, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (PubMed:17057366). Plays also a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:19097999, PubMed:19166269). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:7692601, PubMed:11719189, PubMed:11157796, PubMed:12594214, PubMed:17417632, PubMed:23235829, PubMed:24448548). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (PubMed:23235829). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:11719189, PubMed:18579868, PubMed:25464849, PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (PubMed:7692601, PubMed:11532944, PubMed:12594214, PubMed:15282548, PubMed:18653529). Binds also to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (PubMed:15805463). Binds mRNAs containing U-rich target sequences (PubMed:12927206). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain (PubMed:14703574, PubMed:17057366). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (PubMed:18936162). In vitro, binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:7688265, PubMed:7781595, PubMed:12950170, PubMed:15381419, PubMed:8156595). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteosomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Recently, has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). Finally, FMR1 may be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AX/H2A.x and BRCA1 phosphorylations (PubMed:24813610). Indicus|evm.model.CM009520.1.239 Q7YQM1 AFF2_PONPY 87.915 0.945559 0.274371 AFF2 - AF4/FMR2 family member 2 - Pongo pygmaeus (Bornean orangutan) - AFF2 gene RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure (By similarity). Indicus|evm.model.CM009520.1.240 Q7YQM1 AFF2_PONPY 86.409 0.902273 0.691824 AFF2 - AF4/FMR2 family member 2 - Pongo pygmaeus (Bornean orangutan) - AFF2 gene RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure (By similarity). Indicus|evm.model.CM009520.1.241 Q3T090 TSR2_BOVIN 78.750 0.887006 0.931579 TSR2 - Pre-rRNA-processing protein TSR2 homolog - Bos taurus (Bovine) - TSR2 gene May be involved in 20S pre-rRNA processing. Indicus|evm.model.CM009520.1.243 P22304 IDS_HUMAN 78.916 0.989083 0.832727 IDS - Iduronate 2-sulfatase precursor - Homo sapiens (Human) - IDS gene Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. Indicus|evm.model.CM009520.1.244 Q8TE69 EOLA1_HUMAN 63.636 0.628099 0.765823 EOLA1 - Protein EOLA1 - Homo sapiens (Human) - EOLA1 gene May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expession (PubMed:24916366). Indicus|evm.model.CM009520.1.245 P43365 MAGAC_HUMAN 51.852 0.416667 1.22293 MAGEA12 - Melanoma-associated antigen 12 - Homo sapiens (Human) - MAGEA12 gene Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. Indicus|evm.model.CM009520.1.246 P43357 MAGA3_HUMAN 47.847 0.787072 0.83758 MAGEA3 - Melanoma-associated antigen 3 - Homo sapiens (Human) - MAGEA3 gene Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Indicus|evm.model.CM009520.1.247 P43362 MAGA9_HUMAN 49.254 0.552036 0.701587 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.248 P43362 MAGA9_HUMAN 46.067 0.397129 1.32698 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.249 Q8CD54 PIEZ2_MOUSE 78.689 0.174419 0.121899 Piezo2 - Piezo-type mechanosensitive ion channel component 2 - Mus musculus (Mouse) - Piezo2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:20813920, PubMed:24717433). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886). Indicus|evm.model.CM009520.1.250 Q9H5I5 PIEZ2_HUMAN 78.169 0.844311 0.0606831 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Indicus|evm.model.CM009520.1.251 A7MB35 ODPA_BOVIN 80.952 0.987097 0.397436 PDHA1 - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor - Bos taurus (Bovine) - PDHA1 gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Indicus|evm.model.CM009520.1.252 Q8CD54 PIEZ2_MOUSE 82.759 0.511905 0.0595322 Piezo2 - Piezo-type mechanosensitive ion channel component 2 - Mus musculus (Mouse) - Piezo2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:20813920, PubMed:24717433). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886). Indicus|evm.model.CM009520.1.253 P43355 MAGA1_HUMAN 56.818 0.494297 0.851133 MAGEA1 - Melanoma-associated antigen 1 - Homo sapiens (Human) - MAGEA1 gene May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Indicus|evm.model.CM009520.1.254 P43357 MAGA3_HUMAN 48.293 0.771863 0.83758 MAGEA3 - Melanoma-associated antigen 3 - Homo sapiens (Human) - MAGEA3 gene Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Indicus|evm.model.CM009520.1.256 P43363 MAGAA_HUMAN 60.606 0.120594 1.4607 MAGEA10 - Melanoma-associated antigen 10 - Homo sapiens (Human) - MAGEA10 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.257 P43362 MAGA9_HUMAN 46.667 0.566667 0.666667 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.258 P43361 MAGA8_HUMAN 49.618 0.53719 0.761006 MAGEA8 - Melanoma-associated antigen 8 - Homo sapiens (Human) - MAGEA8 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.261 Q96LI6 HSFY1_HUMAN 50.420 0.542453 0.528678 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009520.1.262 Q8CD54 PIEZ2_MOUSE 88.732 0.736842 0.0336641 Piezo2 - Piezo-type mechanosensitive ion channel component 2 - Mus musculus (Mouse) - Piezo2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:20813920, PubMed:24717433). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886). Indicus|evm.model.CM009520.1.263 P43363 MAGAA_HUMAN 54.245 0.805344 0.710027 MAGEA10 - Melanoma-associated antigen 10 - Homo sapiens (Human) - MAGEA10 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.264 P43362 MAGA9_HUMAN 49.612 0.53112 0.765079 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.265 P43362 MAGA9_HUMAN 54.639 0.336842 0.904762 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.266 Q8TE69 EOLA1_HUMAN 63.158 0.290155 1.22152 EOLA1 - Protein EOLA1 - Homo sapiens (Human) - EOLA1 gene May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expession (PubMed:24916366). Indicus|evm.model.CM009520.1.267 P43362 MAGA9_HUMAN 52.703 0.910828 0.498413 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.268 P43363 MAGAA_HUMAN 49.451 0.989071 0.495935 MAGEA10 - Melanoma-associated antigen 10 - Homo sapiens (Human) - MAGEA10 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.269 A2AF53 T185A_MOUSE 99.143 0.840964 1.18571 Tmem185a - Transmembrane protein 185A - Mus musculus (Mouse) - Tmem185a gene dendrite Indicus|evm.model.CM009520.1.271 P43362 MAGA9_HUMAN 51.402 0.80303 0.838095 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.272 P43362 MAGA9_HUMAN 52.027 0.67907 0.68254 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.273 Q13495 MAMD1_HUMAN 64.512 0.997006 0.863049 MAMLD1 - Mastermind-like domain-containing protein 1 - Homo sapiens (Human) - MAMLD1 gene Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. Indicus|evm.model.CM009520.1.275 A6QLT4 MTM1_BOVIN 100.000 0.967846 1.03151 MTM1 - Myotubularin - Bos taurus (Bovine) - MTM1 gene Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels. Indicus|evm.model.CM009520.1.276 Q13613 MTMR1_HUMAN 94.221 0.996497 0.858647 MTMR1 - Myotubularin-related protein 1 - Homo sapiens (Human) - MTMR1 gene Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:11733541, PubMed:27018598). Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown by PubMed:27018598, while PubMed:11733541 find no activity with this substrate. Indicus|evm.model.CM009520.1.277 A1A4K1 C99L2_BOVIN 98.876 0.624113 0.64977 CD99L2 - CD99 antigen-like protein 2 precursor - Bos taurus (Bovine) - CD99L2 gene Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). Indicus|evm.model.CM009520.1.278 Q32L31 HMGB3_BOVIN 99.490 0.719557 1.355 HMGB3 - High mobility group protein B3 - Bos taurus (Bovine) - HMGB3 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). Indicus|evm.model.CM009520.1.279 Q28558 MTR1L_SHEEP 94.957 0.996528 1.00174 GPR50 - Melatonin-related receptor - Ovis aries (Sheep) - GPR50 gene Does not bind melatonin. Indicus|evm.model.CM009520.1.280 A2VDK9 VMA21_BOVIN 100.000 0.558659 1.77228 VMA21 - Vacuolar ATPase assembly integral membrane protein VMA21 - Bos taurus (Bovine) - VMA21 gene Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. Indicus|evm.model.CM009520.1.282 Q16778 H2B2E_HUMAN 90.476 0.984252 1.00794 H2BC21 - Histone H2B type 2-E - Homo sapiens (Human) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009520.1.283 Q9BZD7 TMG3_HUMAN 94.805 0.991379 1.00433 PRRG3 - Transmembrane gamma-carboxyglutamic acid protein 3 precursor - Homo sapiens (Human) - PRRG3 gene integral component of membrane Indicus|evm.model.CM009520.1.284 Q95LA0 FATE1_BOVIN 99.408 0.988235 0.944444 FATE1 - Fetal and adult testis-expressed transcript protein homolog - Bos taurus (Bovine) - FATE1 gene Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. Indicus|evm.model.CM009520.1.285 Q03041 CNGA2_BOVIN 99.698 0.996988 1.00151 CNGA2 - Cyclic nucleotide-gated olfactory channel - Bos taurus (Bovine) - CNGA2 gene Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. Indicus|evm.model.CM009520.1.287 P43363 MAGAA_HUMAN 59.783 0.802632 0.617886 MAGEA10 - Melanoma-associated antigen 10 - Homo sapiens (Human) - MAGEA10 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.288 P78334 GBRE_HUMAN 70.312 0.99596 0.978261 GABRE - Gamma-aminobutyric acid receptor subunit epsilon precursor - Homo sapiens (Human) - GABRE gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Indicus|evm.model.CM009520.1.290 P43355 MAGA1_HUMAN 56.855 0.664865 1.19741 MAGEA1 - Melanoma-associated antigen 1 - Homo sapiens (Human) - MAGEA1 gene May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Indicus|evm.model.CM009520.1.291 P10064 GBRA3_BOVIN 99.797 0.970356 1.02846 GABRA3 - Gamma-aminobutyric acid receptor subunit alpha-3 precursor - Bos taurus (Bovine) - GABRA3 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Indicus|evm.model.CM009520.1.293 Q9UN88 GBRT_HUMAN 62.482 0.997063 1.07753 GABRQ - Gamma-aminobutyric acid receptor subunit theta precursor - Homo sapiens (Human) - GABRQ gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Indicus|evm.model.CM009520.1.294 P43355 MAGA1_HUMAN 53.232 0.772189 1.09385 MAGEA1 - Melanoma-associated antigen 1 - Homo sapiens (Human) - MAGEA1 gene May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Indicus|evm.model.CM009520.1.295 Q2TBN3 CETN2_BOVIN 100.000 0.987805 0.953488 CETN2 - Centrin-2 - Bos taurus (Bovine) - CETN2 gene Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). Indicus|evm.model.CM009520.1.296 Q3ZBE9 NSDHL_BOVIN 99.719 0.994398 1.00281 NSDHL - Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating - Bos taurus (Bovine) - NSDHL gene Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis. Plays also a role in the regulation of the endocytic trafficking of EGFR. Indicus|evm.model.CM009520.1.297 O15231 ZN185_HUMAN 57.246 0.978125 0.928882 ZNF185 - Zinc finger protein 185 - Homo sapiens (Human) - ZNF185 gene May be involved in the regulation of cellular proliferation and/or differentiation. Indicus|evm.model.CM009520.1.298 Q8TE69 EOLA1_HUMAN 75.316 0.94012 1.05696 EOLA1 - Protein EOLA1 - Homo sapiens (Human) - EOLA1 gene May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expession (PubMed:24916366). Indicus|evm.model.CM009520.1.299 A0A1B0GWH4 HSFX3_HUMAN 57.273 0.608939 0.537538 HSFX3 - Heat shock transcription factor, X-linked member 3 - Homo sapiens (Human) - HSFX3 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009520.1.300 Q96PV4 PNMA5_HUMAN 58.108 0.831395 0.383929 PNMA5 - Paraneoplastic antigen-like protein 5 - Homo sapiens (Human) - PNMA5 gene identical protein binding, positive regulation of apoptotic process Indicus|evm.model.CM009520.1.301 O97965 STP3_SHEEP 87.324 0.384615 1.65455 Spermatid nuclear transition protein 3 - Ovis aries (Sheep) Indicus|evm.model.CM009520.1.303 O97965 STP3_SHEEP 78.125 0.969231 0.590909 Spermatid nuclear transition protein 3 - Ovis aries (Sheep) Indicus|evm.model.CM009520.1.308 O00370 LORF2_HUMAN 65.188 0.845865 0.417255 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Indicus|evm.model.CM009520.1.309 Q8TE69 EOLA1_HUMAN 62.162 0.202778 2.27848 EOLA1 - Protein EOLA1 - Homo sapiens (Human) - EOLA1 gene May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expession (PubMed:24916366). Indicus|evm.model.CM009520.1.310 A0A1B0GWH4 HSFX3_HUMAN 48.378 0.936111 1.08108 HSFX3 - Heat shock transcription factor, X-linked member 3 - Homo sapiens (Human) - HSFX3 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009520.1.311 P43362 MAGA9_HUMAN 55.285 0.159061 2.43492 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.315 Q5R9Q6 RAMAC_PONAB 94.068 0.983193 1.00847 RAMAC - RNA guanine-N7 methyltransferase activating subunit - Pongo abelii (Sumatran orangutan) - RAMAC gene Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT. Regulates RNMT expression by a post-transcriptional stabilizing mechanism. Binds RNA. Indicus|evm.model.CM009520.1.316 Q9H5I5 PIEZ2_HUMAN 63.333 0.640187 0.0777616 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Indicus|evm.model.CM009520.1.317 P51809 VAMP7_HUMAN 82.759 0.972973 0.672727 VAMP7 - Vesicle-associated membrane protein 7 - Homo sapiens (Human) - VAMP7 gene Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. Indicus|evm.model.CM009520.1.318 O43610 SPY3_HUMAN 96.528 0.99308 1.00347 SPRY3 - Protein sprouty homolog 3 - Homo sapiens (Human) - SPRY3 gene Inhibits neurite branching, arbor length and neurite complexity (By similarity). Inhibits EGF-mediated p42/44 ERK signaling (By similarity). Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation (PubMed:30878395). May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (PubMed:9458049). Indicus|evm.model.CM009520.1.319 Q0VC74 TMLH_BOVIN 100.000 0.99308 0.686461 TMLHE - Trimethyllysine dioxygenase, mitochondrial precursor - Bos taurus (Bovine) - TMLHE gene Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). Indicus|evm.model.CM009520.1.320 Q5R5C3 FAM3A_PONAB 74.359 0.529412 0.295652 FAM3A - Protein FAM3A precursor - Pongo abelii (Sumatran orangutan) - FAM3A gene Indicus|evm.model.CM009520.1.321 Q0VC74 TMLH_BOVIN 100.000 0.659218 0.425178 TMLHE - Trimethyllysine dioxygenase, mitochondrial precursor - Bos taurus (Bovine) - TMLHE gene Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). Indicus|evm.model.CM009520.1.322 O15247 CLIC2_HUMAN 93.522 0.991935 1.00405 CLIC2 - Chloride intracellular channel protein 2 - Homo sapiens (Human) - CLIC2 gene Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. Indicus|evm.model.CM009520.1.323 Q58DW0 RL4_BOVIN 88.416 0.995025 0.952607 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Indicus|evm.model.CM009520.1.326 Q17QU4 RB39B_BOVIN 100.000 0.990654 1.00469 RAB39B - Ras-related protein Rab-39B - Bos taurus (Bovine) - RAB39B gene Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (By similarity). Indicus|evm.model.CM009520.1.327 Q2HJ33 OLA1_BOVIN 99.495 0.994962 1.00253 OLA1 - Obg-like ATPase 1 - Bos taurus (Bovine) - OLA1 gene Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. Indicus|evm.model.CM009520.1.328 Q2TBX2 PFD3_BOVIN 99.492 0.989899 1.00508 VBP1 - Prefoldin subunit 3 - Bos taurus (Bovine) - VBP1 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Indicus|evm.model.CM009520.1.329 O55012 PICAL_RAT 67.407 0.788856 0.532813 Picalm - Phosphatidylinositol-binding clathrin assembly protein - Rattus norvegicus (Rat) - Picalm gene Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF). Indicus|evm.model.CM009520.1.330 A5PJP6 BRCC3_BOVIN 100.000 0.946903 0.357595 BRCC3 - Lys-63-specific deubiquitinase BRCC36 - Bos taurus (Bovine) - BRCC3 gene Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Indicus|evm.model.CM009520.1.331 A5PJP6 BRCC3_BOVIN 84.431 0.731278 0.718354 BRCC3 - Lys-63-specific deubiquitinase BRCC36 - Bos taurus (Bovine) - BRCC3 gene Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Indicus|evm.model.CM009520.1.332 P56278 MTCP1_HUMAN 94.393 0.981481 1.00935 MTCP1 - Protein p13 MTCP-1 - Homo sapiens (Human) - MTCP1 gene Enhances the phosphorylation and activation of AKT1 and AKT2. Indicus|evm.model.CM009520.1.333 Q0VBY0 CMC4_BOVIN 100.000 0.683673 1.44118 CMC4 - Cx9C motif-containing protein 4 - Bos taurus (Bovine) - CMC4 gene mitochondrial intermembrane space Indicus|evm.model.CM009520.1.334 Q8MJN0 FUND2_BOVIN 100.000 0.989529 1.00526 FUNDC2 - FUN14 domain-containing protein 2 - Bos taurus (Bovine) - FUNDC2 gene integral component of mitochondrial outer membrane, autophagy of mitochondrion Indicus|evm.model.CM009520.1.335 P12263 FA8_PIG 78.057 0.400885 1.05954 F8 - Coagulation factor VIII precursor - Sus scrofa (Pig) - F8 gene Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Indicus|evm.model.CM009520.1.336 Q17QN6 EM55_BOVIN 99.571 0.995717 1.00215 MPP1 - 55 kDa erythrocyte membrane protein - Bos taurus (Bovine) - MPP1 gene Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). Indicus|evm.model.CM009520.1.337 O60832 DKC1_HUMAN 91.356 0.860585 1.13035 DKC1 - H/ACA ribonucleoprotein complex subunit DKC1 - Homo sapiens (Human) - DKC1 gene Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). Indicus|evm.model.CM009520.1.338 Q8WWW8 GAB3_HUMAN 77.699 0.985915 0.969283 GAB3 - GRB2-associated-binding protein 3 - Homo sapiens (Human) - GAB3 gene Indicus|evm.model.CM009520.1.339 Q14953 KI2S5_HUMAN 56.098 0.32 0.411184 KIR2DS5 - Killer cell immunoglobulin-like receptor 2DS5 precursor - Homo sapiens (Human) - KIR2DS5 gene Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:28685972, PubMed:18624290, PubMed:18682925). Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry (PubMed:28685972). Indicus|evm.model.CM009520.1.340 Q9H7L2 KI3X1_HUMAN 51.475 0.675 1.25 KIR3DX1 - Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 precursor - Homo sapiens (Human) - KIR3DX1 gene Indicus|evm.model.CM009520.1.341 Q9H7L2 KI3X1_HUMAN 56.500 0.273361 2.03693 KIR3DX1 - Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 precursor - Homo sapiens (Human) - KIR3DX1 gene Indicus|evm.model.CM009520.1.343 Q9NSD4 ZN275_HUMAN 90.426 0.994695 0.878788 ZNF275 - Zinc finger protein 275 - Homo sapiens (Human) - ZNF275 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.344 A0A0J9YXQ4 PMA6E_HUMAN 73.043 0.128378 1.37249 PNMA6E - Paraneoplastic antigen Ma6E - Homo sapiens (Human) - PNMA6E gene Indicus|evm.model.CM009520.1.346 Q9BQ50 TREX2_HUMAN 79.874 0.303263 2.20763 TREX2 - Three prime repair exonuclease 2 - Homo sapiens (Human) - TREX2 gene Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair. Indicus|evm.model.CM009520.1.347 Q3MHH9 ECM2_BOVIN 52.507 0.739216 0.75 ECM2 - Extracellular matrix protein 2 precursor - Bos taurus (Bovine) - ECM2 gene Promotes matrix assembly and cell adhesiveness. Indicus|evm.model.CM009520.1.348 P21809 PGS1_BOVIN 100.000 0.994595 1.00271 BGN - Biglycan precursor - Bos taurus (Bovine) - BGN gene May be involved in collagen fiber assembly. Indicus|evm.model.CM009520.1.349 Q64568 AT2B3_RAT 92.846 0.998358 0.968203 Atp2b3 - Plasma membrane calcium-transporting ATPase 3 - Rattus norvegicus (Rat) - Atp2b3 gene ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:25014339, PubMed:9880546). May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established (PubMed:25014339, PubMed:9880546). Indicus|evm.model.CM009520.1.350 Q8N1B3 CCNQ_HUMAN 88.362 0.920319 1.0121 CCNQ - Cyclin-Q - Homo sapiens (Human) - CCNQ gene Activating cyclin for the cyclin-associated kinase CDK10. Indicus|evm.model.CM009520.1.351 Q99956 DUS9_HUMAN 89.062 0.994751 0.992188 DUSP9 - Dual specificity protein phosphatase 9 - Homo sapiens (Human) - DUSP9 gene Inactivates MAP kinases. Has a specificity for the ERK family. Indicus|evm.model.CM009520.1.352 Q9QYK9 KCC1B_MOUSE 94.081 0.963746 0.965015 Pnck - Calcium/calmodulin-dependent protein kinase type 1B - Mus musculus (Mouse) - Pnck gene Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity). Indicus|evm.model.CM009520.1.353 O18875 SC6A8_BOVIN 100.000 0.99274 0.867717 SLC6A8 - Sodium- and chloride-dependent creatine transporter 1 - Bos taurus (Bovine) - SLC6A8 gene Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity). Indicus|evm.model.CM009520.1.354 Q5R8H3 BAP31_PONAB 88.618 0.99187 1 BCAP31 - B-cell receptor-associated protein 31 - Pongo abelii (Sumatran orangutan) - BCAP31 gene Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (By similarity). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40. In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2. May be involved in CASP8-mediated apoptosis (By similarity). Indicus|evm.model.CM009520.1.355 P48410 ABCD1_MOUSE 89.905 0.991826 0.997283 Abcd1 - ATP-binding cassette sub-family D member 1 - Mus musculus (Mouse) - Abcd1 gene Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:25255441, PubMed:9418970, PubMed:9126326, PubMed:9256488, PubMed:18854420, PubMed:23123468, PubMed:26108493, PubMed:23604518, PubMed:25583114). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance (PubMed:11875044, PubMed:26108493, PubMed:15489218). Controls also the cellular response to oxidative stress by regulating mitochondrial function like, mitochondrial oxidative phosphorylation and depolarization (PubMed:25583114, PubMed:23604518, PubMed:18344354, PubMed:22521832). And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (PubMed:18723473). Indicus|evm.model.CM009520.1.356 Q9ULL4 PLXB3_HUMAN 81.590 0.979668 0.979047 PLXNB3 - Plexin-B3 precursor - Homo sapiens (Human) - PLXNB3 gene Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. Indicus|evm.model.CM009520.1.357 B8Y466 SRPK3_PIG 93.907 0.953767 1.0318 SRPK3 - SRSF protein kinase 3 - Sus scrofa (Pig) - SRPK3 gene Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity). Indicus|evm.model.CM009520.1.358 Q58CP0 IDH3G_BOVIN 100.000 0.994911 1.00255 IDH3G - Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor - Bos taurus (Bovine) - IDH3G gene Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Indicus|evm.model.CM009520.1.359 Q2TBX5 SSRD_BOVIN 99.422 0.988506 1.01163 SSR4 - Translocon-associated protein subunit delta precursor - Bos taurus (Bovine) - SSR4 gene TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Indicus|evm.model.CM009520.1.360 Q76G19 PDZD4_HUMAN 90.407 0.988296 1 PDZD4 - PDZ domain-containing protein 4 - Homo sapiens (Human) - PDZD4 gene Indicus|evm.model.CM009520.1.361 A5JSS2 RL21_CAPHI 98.125 0.987578 1.00625 RPL21 - 60S ribosomal protein L21 - Capra hircus (Goat) - RPL21 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009520.1.362 P32004 L1CAM_HUMAN 89.181 0.998405 0.997613 L1CAM - Neural cell adhesion molecule L1 precursor - Homo sapiens (Human) - L1CAM gene Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. Indicus|evm.model.CM009520.1.363 P48044 V2R_BOVIN 100.000 0.844869 1.13243 AVPR2 - Vasopressin V2 receptor - Bos taurus (Bovine) - AVPR2 gene Receptor for arginine vasopressin (PubMed:7698346, PubMed:8257689). The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity). Indicus|evm.model.CM009520.1.364 P98171 RHG04_HUMAN 85.504 0.997899 1.00634 ARHGAP4 - Rho GTPase-activating protein 4 - Homo sapiens (Human) - ARHGAP4 gene Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. Indicus|evm.model.CM009520.1.365 Q2KI14 NAA10_BOVIN 98.734 0.45614 0.72766 NAA10 - N-alpha-acetyltransferase 10 - Bos taurus (Bovine) - NAA10 gene Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX. Acetylates HIST1H4A. Acts as a negative regulator of sister chromatid cohesion during mitosis. Indicus|evm.model.CM009520.1.366 O18921 RENBP_CANLF 91.429 0.0778032 12.4857 RENBP - N-acylglucosamine 2-epimerase - Canis lupus familiaris (Dog) - RENBP gene Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). Indicus|evm.model.CM009520.1.367 P51611 HCFC1_MESAU 86.686 0.998994 0.951675 HCFC1 - Host cell factor 1 - Mesocricetus auratus (Golden hamster) - HCFC1 gene Involved in control of the cell cycle (PubMed:9087427). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (By similarity). Coactivator for EGR2 and GABP2 (By similarity). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). Recruits KMT2E to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (By similarity). Indicus|evm.model.CM009520.1.368 Q0VCM2 TM187_BOVIN 100.000 0.992218 1.00391 TMEM187 - Transmembrane protein 187 - Bos taurus (Bovine) - TMEM187 gene transport vesicle Indicus|evm.model.CM009520.1.369 Q2LGB3 IRAK1_BOVIN 100.000 0.935933 1 IRAK1 - Interleukin-1 receptor-associated kinase 1 - Bos taurus (Bovine) - IRAK1 gene Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3 (By similarity). Indicus|evm.model.CM009520.1.370 Q95LG8 MECP2_MACFA 95.188 0.924419 1.06173 MECP2 - Methyl-CpG-binding protein 2 - Macaca fascicularis (Crab-eating macaque) - MECP2 gene Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). Indicus|evm.model.CM009520.1.371 Q3SYU2 EF2_BOVIN 77.101 0.995 0.4662 EEF2 - Elongation factor 2 - Bos taurus (Bovine) - EEF2 gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Indicus|evm.model.CM009520.1.372 Q3SYU2 EF2_BOVIN 92.035 0.994118 0.39627 EEF2 - Elongation factor 2 - Bos taurus (Bovine) - EEF2 gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Indicus|evm.model.CM009520.1.373 Q9BGI7 OPSR_BOVIN 100.000 0.994521 1.00275 OPN1LW - Long-wave-sensitive opsin 1 - Bos taurus (Bovine) - OPN1LW gene Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Indicus|evm.model.CM009520.1.374 O15482 TEX28_HUMAN 61.951 0.995122 1 TEX28 - Testis-specific protein TEX28 - Homo sapiens (Human) - TEX28 gene endomembrane system Indicus|evm.model.CM009520.1.375 Q2NL26 TKTL1_BOVIN 99.497 0.99665 1.00168 TKTL1 - Transketolase-like protein 1 - Bos taurus (Bovine) - TKTL1 gene Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Indicus|evm.model.CM009520.1.377 P21333 FLNA_HUMAN 97.137 0.97124 0.972044 FLNA - Filamin-A - Homo sapiens (Human) - FLNA gene Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). Indicus|evm.model.CM009520.1.378 O08579 EMD_MOUSE 85.441 0.992366 1.01158 Emd - Emerin - Mus musculus (Mouse) - Emd gene Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C (By similarity). Indicus|evm.model.CM009520.1.380 A8D8X1 RL10_SHEEP 100.000 0.603399 1.64953 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Indicus|evm.model.CM009520.1.381 Q2QDE9 DNSL1_BOVIN 99.606 0.992157 0.806962 DNASE1L1 - Deoxyribonuclease-1-like 1 precursor - Bos taurus (Bovine) - DNASE1L1 gene nucleus, deoxyribonuclease I activity, DNA binding, DNA catabolic process, DNA catabolic process, endonucleolytic Indicus|evm.model.CM009520.1.382 Q6IV78 TAZ_SAISC 98.456 0.984733 1 TAZ - Tafazzin - Saimiri sciureus (Common squirrel monkey) - TAZ gene Acyltransferase which is required to maintain the composition of the phospholipid cardiolipin, a key component of the mitochondrial inner membrane (By similarity). Required for the initiation of mitophagy (By similarity). Required to ensure progression of spermatocytes through meiosis (By similarity). Indicus|evm.model.CM009520.1.383 P40682 VAS1_BOVIN 99.381 0.936047 0.735043 ATP6AP1 - V-type proton ATPase subunit S1 precursor - Bos taurus (Bovine) - ATP6AP1 gene Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). Indicus|evm.model.CM009520.1.384 P21856 GDIA_BOVIN 100.000 0.995536 1.00224 GDI1 - Rab GDP dissociation inhibitor alpha - Bos taurus (Bovine) - GDI1 gene Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. Indicus|evm.model.CM009520.1.385 Q9WV03 FA50A_MOUSE 97.929 0.346351 2.87021 Fam50a - Protein FAM50A - Mus musculus (Mouse) - Fam50a gene Probably involved in the regulation of pre-mRNA splicing. Indicus|evm.model.CM009520.1.386 P51805 PLXA3_HUMAN 88.925 0.674928 0.927312 PLXNA3 - Plexin-A3 precursor - Homo sapiens (Human) - PLXNA3 gene Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Indicus|evm.model.CM009520.1.387 O55044 G6PD_CRIGR 95.385 0.602941 1.45243 G6PD - Glucose-6-phosphate 1-dehydrogenase - Cricetulus griseus (Chinese hamster) - G6PD gene Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes. Indicus|evm.model.CM009520.1.388 Q95KU9 NEMO_BOVIN 99.523 0.995238 1.00239 IKBKG - NF-kappa-B essential modulator - Bos taurus (Bovine) - IKBKG gene Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much highr affinity for linear polyubiquitin. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. Indicus|evm.model.CM009520.1.389 Q14657 LAGE3_HUMAN 50.794 0.212329 2.04196 LAGE3 - EKC/KEOPS complex subunit LAGE3 - Homo sapiens (Human) - LAGE3 gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. Indicus|evm.model.CM009520.1.390 Q8NDT2 RB15B_HUMAN 79.245 0.81078 0.979775 RBM15B - Putative RNA-binding protein 15B - Homo sapiens (Human) - RBM15B gene RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). Indicus|evm.model.CM009520.1.391 P42658 DPP6_HUMAN 80.952 0.136667 0.346821 DPP6 - Dipeptidyl aminopeptidase-like protein 6 - Homo sapiens (Human) - DPP6 gene Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821). Indicus|evm.model.CM009520.1.393 Q5JSZ5 PRC2B_HUMAN 62.500 0.205674 0.189771 PRRC2B - Protein PRRC2B - Homo sapiens (Human) - PRRC2B gene RNA binding, cell differentiation Indicus|evm.model.CM009520.1.395 P0DME0 SETLP_HUMAN 72.500 0.216667 0.596026 SETSIP - Protein SETSIP - Homo sapiens (Human) - SETSIP gene Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter. Indicus|evm.model.CM009520.1.396 P43362 MAGA9_HUMAN 47.486 0.565079 1 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.400 Q5JSZ5 PRC2B_HUMAN 80.000 0.264574 0.100045 PRRC2B - Protein PRRC2B - Homo sapiens (Human) - PRRC2B gene RNA binding, cell differentiation Indicus|evm.model.CM009520.1.401 Q9NQV7 PRDM9_HUMAN 73.421 0.935802 0.45302 PRDM9 - Histone-lysine N-methyltransferase PRDM9 - Homo sapiens (Human) - PRDM9 gene Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:24634223, PubMed:24095733, PubMed:26833727). Also can methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24095733, PubMed:24634223, PubMed:26833727). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (By similarity). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:26833727). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (By similarity). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (By similarity). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (By similarity). In addition performs automethylation (By similarity). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (By similarity). Indicus|evm.model.CM009520.1.402 A0A1B0GWH4 HSFX3_HUMAN 58.904 0.734694 0.294294 HSFX3 - Heat shock transcription factor, X-linked member 3 - Homo sapiens (Human) - HSFX3 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009520.1.403 P43362 MAGA9_HUMAN 39.091 0.4 0.666667 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Indicus|evm.model.CM009520.1.404 Q5RAX6 EOLAL_PONAB 64.706 0.666667 0.797468 EOLA-like protein - Pongo abelii (Sumatran orangutan) Indicus|evm.model.CM009520.1.405 A0A1B0GWH4 HSFX3_HUMAN 52.000 0.566434 1.71772 HSFX3 - Heat shock transcription factor, X-linked member 3 - Homo sapiens (Human) - HSFX3 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009520.1.407 Q60453 TIMP2_CRILO 83.333 0.234694 0.5 TIMP2 - Metalloproteinase inhibitor 2 precursor - Cricetulus longicaudatus (Long-tailed dwarf hamster) - TIMP2 gene Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Indicus|evm.model.CM009520.1.409 Q2HJG5 VPS35_BOVIN 88.921 0.99683 0.792714 VPS35 - Vacuolar protein sorting-associated protein 35 - Bos taurus (Bovine) - VPS35 gene Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for endosomal localization of WASHC2. Mediates the association of the CSC with the WASH complex via WASHC2. Required for the endosomal localization of TBC1D5 (By similarity). Indicus|evm.model.CM009520.1.410 P60050 PABP5_PONPY 96.325 0.992167 1.00262 PABPC5 - Polyadenylate-binding protein 5 - Pongo pygmaeus (Bornean orangutan) - PABPC5 gene Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). Indicus|evm.model.CM009520.1.413 Q9Y3E1 HDGR3_HUMAN 85.915 0.404624 0.852217 HDGFL3 - Hepatoma-derived growth factor-related protein 3 - Homo sapiens (Human) - HDGFL3 gene Enhances DNA synthesis and may play a role in cell proliferation. Indicus|evm.model.CM009520.1.414 Q6KEQ9 PC11X_PIG 92.186 0.998016 0.902417 PCDH11X - Protocadherin-11 X-linked precursor - Sus scrofa (Pig) - PCDH11X gene Potential calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009520.1.417 O02751 CFDP2_BOVIN 65.116 0.833333 0.172297 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Indicus|evm.model.CM009520.1.419 Q9NRJ5 PAPOB_HUMAN 79.798 0.941748 0.16195 PAPOLB - Poly(A) polymerase beta - Homo sapiens (Human) - PAPOLB gene nucleus, polynucleotide adenylyltransferase activity, mRNA polyadenylation Indicus|evm.model.CM009520.1.421 Q8N9E0 F133A_HUMAN 95.238 0.332 1.00806 FAM133A - Protein FAM133A - Homo sapiens (Human) - FAM133A gene Indicus|evm.model.CM009520.1.425 P42174 DHE3_PIG 79.661 0.983193 0.213262 GLUD1 - Glutamate dehydrogenase 1, mitochondrial precursor - Sus scrofa (Pig) - GLUD1 gene Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:8240242). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). Indicus|evm.model.CM009520.1.426 P00366 DHE3_BOVIN 82.870 0.990698 0.385305 GLUD1 - Glutamate dehydrogenase 1, mitochondrial precursor - Bos taurus (Bovine) - GLUD1 gene Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:4365183, PubMed:14659072). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). Indicus|evm.model.CM009520.1.427 A8MXT2 MAGBH_HUMAN 52.027 0.948052 0.916667 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Indicus|evm.model.CM009520.1.428 Q64674 SPEE_MOUSE 45.070 0.92381 0.347682 Srm - Spermidine synthase - Mus musculus (Mouse) - Srm gene Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine (By similarity). Indicus|evm.model.CM009520.1.429 Q8ISN9 RS25_BRABE 72.093 0.531646 0.642276 RPS25 - 40S ribosomal protein S25 - Branchiostoma belcheri (Amphioxus) - RPS25 gene Indicus|evm.model.CM009520.1.430 O60879 DIAP2_HUMAN 96.875 0.668421 0.17257 DIAPH2 - Protein diaphanous homolog 2 - Homo sapiens (Human) - DIAPH2 gene Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. Indicus|evm.model.CM009520.1.431 O60879 DIAP2_HUMAN 89.865 0.687059 0.386013 DIAPH2 - Protein diaphanous homolog 2 - Homo sapiens (Human) - DIAPH2 gene Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. Indicus|evm.model.CM009520.1.432 Q58DT1 RL7_BOVIN 97.984 0.991968 1.00403 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Indicus|evm.model.CM009520.1.433 O60879 DIAP2_HUMAN 91.960 0.965854 0.186194 DIAPH2 - Protein diaphanous homolog 2 - Homo sapiens (Human) - DIAPH2 gene Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. Indicus|evm.model.CM009520.1.435 P70696 H2B1A_MOUSE 45.614 0.861538 1.02362 H2bc1 - Histone H2B type 1-A - Mus musculus (Mouse) - H2bc1 gene Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (PubMed:23884607, PubMed:28366643). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (PubMed:23884607). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (PubMed:23884607). Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009520.1.436 Q8JHJ1 RL35_DANRE 58.209 0.606061 0.804878 rpl35 - 60S ribosomal protein L35 - Danio rerio (Zebrafish) - rpl35 gene Plays an essential role in early embryonic development. May act as a haploinsufficient tumor suppressor. Indicus|evm.model.CM009520.1.437 Q8IUQ4 SIAH1_HUMAN 76.786 0.985816 1 SIAH1 - E3 ubiquitin-protein ligase SIAH1 - Homo sapiens (Human) - SIAH1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:10747903, PubMed:11146551, PubMed:11389839, PubMed:11389840, PubMed:11483517, PubMed:11483518, PubMed:11752454, PubMed:12072443). Confers constitutive instability to HIPK2 through proteasomal degradation (PubMed:18536714). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Has some overlapping function with SIAH2 (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (By similarity). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Indicus|evm.model.CM009520.1.438 Q6P1M9 ARMX5_HUMAN 74.900 0.995943 0.883513 ARMCX5 - Armadillo repeat-containing X-linked protein 5 - Homo sapiens (Human) - ARMCX5 gene Indicus|evm.model.CM009520.1.439 Q5JY77 GASP1_HUMAN 62.524 0.998049 0.734767 GPRASP1 - G-protein coupled receptor-associated sorting protein 1 - Homo sapiens (Human) - GPRASP1 gene Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2. Indicus|evm.model.CM009520.1.440 Q5JY77 GASP1_HUMAN 78.979 0.991045 0.240143 GPRASP1 - G-protein coupled receptor-associated sorting protein 1 - Homo sapiens (Human) - GPRASP1 gene Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2. Indicus|evm.model.CM009520.1.441 Q5R7U0 GASP2_PONAB 81.183 0.855984 1.17661 GPRASP2 - G-protein coupled receptor-associated sorting protein 2 - Pongo abelii (Sumatran orangutan) - GPRASP2 gene May play a role in regulation of a variety of G-protein coupled receptors. Indicus|evm.model.CM009520.1.442 Q9BE11 BHLH9_MACFA 72.760 0.975395 1.04022 BHLHB9 - Protein BHLHb9 - Macaca fascicularis (Crab-eating macaque) - BHLHB9 gene May play a role in the control of cellular aging and survival. Indicus|evm.model.CM009520.1.446 Q8IV48 ERI1_HUMAN 86.462 0.366516 2.53295 ERI1 - 3'-5' exoribonuclease 1 - Homo sapiens (Human) - ERI1 gene RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Indicus|evm.model.CM009520.1.447 Q2TBV0 BEX2_BOVIN 99.219 0.671958 1.47656 BEX2 - Protein BEX2 - Bos taurus (Bovine) - BEX2 gene Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity). Indicus|evm.model.CM009520.1.448 Q0IIM1 RN168_BOVIN 71.654 0.961832 0.228621 RNF168 - E3 ubiquitin-protein ligase RNF168 - Bos taurus (Bovine) - RNF168 gene E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). Indicus|evm.model.CM009520.1.449 Q5EA25 SRPX2_BOVIN 95.168 0.995807 1.02581 SRPX2 - Sushi repeat-containing protein SRPX2 precursor - Bos taurus (Bovine) - SRPX2 gene Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation (By similarity). Indicus|evm.model.CM009520.1.450 Q32KU6 TSN6_BOVIN 100.000 0.99187 1.00408 TSPAN6 - Tetraspanin-6 - Bos taurus (Bovine) - TSPAN6 gene integral component of plasma membrane Indicus|evm.model.CM009520.1.451 Q9H2S6 TNMD_HUMAN 96.541 0.99373 1.00631 TNMD - Tenomodulin - Homo sapiens (Human) - TNMD gene May be an angiogenesis inhibitor. Indicus|evm.model.CM009520.1.452 Q8TAB3 PCD19_HUMAN 93.380 0.99818 0.957317 PCDH19 - Protocadherin-19 precursor - Homo sapiens (Human) - PCDH19 gene Potential calcium-dependent cell-adhesion protein. Indicus|evm.model.CM009520.1.453 Q2F7J3 POL_XMRV3 56.828 0.605405 0.213503 gag-pol - Gag-Pol polyprotein - Xenotropic MuLV-related virus (isolate VP35) (XMRV) - gag-pol gene Matrix protein p15 targets Gag and gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity). Indicus|evm.model.CM009520.1.454 Q9NP60 IRPL2_HUMAN 97.826 0.827273 0.16035 IL1RAPL2 - X-linked interleukin-1 receptor accessory protein-like 2 precursor - Homo sapiens (Human) - IL1RAPL2 gene glutamatergic synapse, plasma membrane, interleukin-1 receptor activity, central nervous system development, regulation of presynapse assembly Indicus|evm.model.CM009520.1.455 Q9BXU2 TX13B_HUMAN 60.215 0.45297 1.29487 TEX13B - Testis-expressed protein 13B - Homo sapiens (Human) - TEX13B gene Indicus|evm.model.CM009520.1.456 A4IFL2 SMAGP_BOVIN 61.111 0.956522 0.71134 SMAGP - Small cell adhesion glycoprotein - Bos taurus (Bovine) - SMAGP gene May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation (By similarity). Indicus|evm.model.CM009520.1.457 P63170 DYL1_RAT 97.753 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Indicus|evm.model.CM009520.1.458 Q9NP60 IRPL2_HUMAN 94.872 0.961798 0.648688 IL1RAPL2 - X-linked interleukin-1 receptor accessory protein-like 2 precursor - Homo sapiens (Human) - IL1RAPL2 gene glutamatergic synapse, plasma membrane, interleukin-1 receptor activity, central nervous system development, regulation of presynapse assembly Indicus|evm.model.CM009520.1.459 Q7Z2Y5 NRK_HUMAN 95.904 0.945205 0.276865 NRK - Nik-related protein kinase - Homo sapiens (Human) - NRK gene May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). Indicus|evm.model.CM009520.1.460 Q7Z2Y5 NRK_HUMAN 78.184 0.992933 0.536662 NRK - Nik-related protein kinase - Homo sapiens (Human) - NRK gene May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). Indicus|evm.model.CM009520.1.461 Q7Z2Y5 NRK_HUMAN 91.713 0.779221 0.146018 NRK - Nik-related protein kinase - Homo sapiens (Human) - NRK gene May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). Indicus|evm.model.CM009520.1.462 Q9TT36 THBG_BOVIN 99.513 0.995146 1.00243 SERPINA7 - Thyroxine-binding globulin precursor - Bos taurus (Bovine) - SERPINA7 gene Major thyroid hormone transport protein in serum. Indicus|evm.model.CM009520.1.464 Q5H9M0 PWP3B_HUMAN 76.791 0.997122 0.998563 PWWP3B - PWWP domain-containing DNA repair factor 3B - Homo sapiens (Human) - PWWP3B gene extracellular exosome Indicus|evm.model.CM009520.1.465 Q5R4D4 NP1L1_PONAB 66.667 0.098434 1.14322 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Pongo abelii (Sumatran orangutan) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Indicus|evm.model.CM009520.1.468 Q9CR70 LAGE3_MOUSE 45.570 0.865169 0.601351 Lage3 - EKC/KEOPS complex subunit Lage3 - Mus musculus (Mouse) - Lage3 gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. Indicus|evm.model.CM009520.1.474 Q96C24 SYTL4_HUMAN 92.250 0.997024 1.00149 SYTL4 - Synaptotagmin-like protein 4 - Homo sapiens (Human) - SYTL4 gene Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). Indicus|evm.model.CM009520.1.475 Q8HXM1 CSTF2_BOVIN 100.000 0.99651 1.00175 CSTF2 - Cleavage stimulation factor subunit 2 - Bos taurus (Bovine) - CSTF2 gene One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). Indicus|evm.model.CM009520.1.476 Q9Y5S8 NOX1_HUMAN 79.965 0.996234 0.941489 NOX1 - NADPH oxidase 1 - Homo sapiens (Human) - NOX1 gene NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. Indicus|evm.model.CM009520.1.477 Q6PP77 XKR2_HUMAN 93.541 0.995556 1.00223 XKRX - XK-related protein 2 - Homo sapiens (Human) - XKRX gene Indicus|evm.model.CM009520.1.478 Q5E9T5 TM35A_BOVIN 100.000 0.303448 3.27684 TMEM35A - Novel acetylcholine receptor chaperone - Bos taurus (Bovine) - TMEM35A gene Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (By similarity). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (By similarity). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (By similarity). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity). Indicus|evm.model.CM009520.1.479 Q92674 CENPI_HUMAN 81.745 0.997238 0.957672 CENPI - Centromere protein I - Homo sapiens (Human) - CENPI gene Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. Indicus|evm.model.CM009520.1.480 Q13474 DRP2_HUMAN 94.253 0.997912 1.00104 DRP2 - Dystrophin-related protein 2 - Homo sapiens (Human) - DRP2 gene Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system. Indicus|evm.model.CM009520.1.481 Q5H9L4 TAF7L_HUMAN 59.910 0.993135 0.945887 TAF7L - Transcription initiation factor TFIID subunit 7-like - Homo sapiens (Human) - TAF7L gene Probably functions as a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis (By similarity). Indicus|evm.model.CM009520.1.482 Q3ZBS8 TIM8A_BOVIN 100.000 0.979592 1.01031 TIMM8A - Mitochondrial import inner membrane translocase subunit Tim8 A - Bos taurus (Bovine) - TIMM8A gene Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity). Indicus|evm.model.CM009520.1.483 Q06187 BTK_HUMAN 98.634 0.99697 1.00152 BTK - Tyrosine-protein kinase BTK - Homo sapiens (Human) - BTK gene Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis. Indicus|evm.model.CM009520.1.484 P83883 RL36A_RAT 100.000 0.483871 2.04717 Rpl36a - 60S ribosomal protein L36a - Rattus norvegicus (Rat) - Rpl36a gene cytosolic large ribosomal subunit, nucleus, response to organic substance, response to retinoic acid Indicus|evm.model.CM009520.1.485 P06280 AGAL_HUMAN 80.872 0.936364 1.02564 GLA - Alpha-galactosidase A precursor - Homo sapiens (Human) - GLA gene Catalyzes the hydrolysis of glycosphingolipids and participates to their degradation in the lysosome. Indicus|evm.model.CM009520.1.486 Q3SZF3 HNRH2_BOVIN 99.777 0.995556 1.00223 HNRNPH2 - Heterogeneous nuclear ribonucleoprotein H2 - Bos taurus (Bovine) - HNRNPH2 gene This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity). Indicus|evm.model.CM009520.1.487 Q5R9J3 ARMX3_PONAB 62.791 0.0181191 6.11609 ARMCX3 - Armadillo repeat-containing X-linked protein 3 - Pongo abelii (Sumatran orangutan) - ARMCX3 gene Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. Indicus|evm.model.CM009520.1.488 P67829 KC1A_SHEEP 78.348 0.964088 1.11385 CSNK1A1 - Casein kinase I isoform alpha - Ovis aries (Sheep) - CSNK1A1 gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Indicus|evm.model.CM009520.1.490 Q9P291 ARMX1_HUMAN 85.649 0.964758 1.00221 ARMCX1 - Armadillo repeat-containing X-linked protein 1 - Homo sapiens (Human) - ARMCX1 gene Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. Indicus|evm.model.CM009520.1.491 Q7L4S7 ARMX6_HUMAN 73.754 0.990066 1.00667 ARMCX6 - Protein ARMCX6 - Homo sapiens (Human) - ARMCX6 gene May regulate the dynamics and distribution of mitochondria in neural cells. Indicus|evm.model.CM009520.1.492 Q5R9J3 ARMX3_PONAB 95.515 0.994737 1.00264 ARMCX3 - Armadillo repeat-containing X-linked protein 3 - Pongo abelii (Sumatran orangutan) - ARMCX3 gene Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. Indicus|evm.model.CM009520.1.493 Q6A058 ARMX2_MOUSE 85.581 0.701639 0.778061 Armcx2 - Armadillo repeat-containing X-linked protein 2 - Mus musculus (Mouse) - Armcx2 gene May regulate the dynamics and distribution of mitochondria in neural cells. Indicus|evm.model.CM009520.1.494 Q9GZY0 NXF2_HUMAN 65.862 0.946401 1.04313 NXF2 - Nuclear RNA export factor 2 - Homo sapiens (Human) - NXF2 gene Involved in the export of mRNA from the nucleus to the cytoplasm. Indicus|evm.model.CM009520.1.496 Q28EG9 ZMAT1_XENTR 71.795 0.0474407 1.44846 zmat1 - Zinc finger matrin-type protein 1 - Xenopus tropicalis (Western clawed frog) - zmat1 gene Indicus|evm.model.CM009520.1.497 Q3ZBJ9 BEX5_BOVIN 100.000 0.685185 1.44643 BEX5 - Protein BEX5 - Bos taurus (Bovine) - BEX5 gene cytoplasm, signaling receptor binding, signal transduction Indicus|evm.model.CM009520.1.500 B4DZS4 T11X1_HUMAN 75.094 0.50478 1.67628 TCP11X1 - T-complex protein 11 X-linked protein 1 - Homo sapiens (Human) - TCP11X1 gene acrosomal vesicle, sperm flagellum, protein kinase A signaling, regulation of sperm capacitation, signal transduction Indicus|evm.model.CM009520.1.502 Q9H4D5 NXF3_HUMAN 70.330 0.0687023 2.46704 NXF3 - Nuclear RNA export factor 3 - Homo sapiens (Human) - NXF3 gene May function as a tissue-specific nuclear mRNA export factor. Indicus|evm.model.CM009520.1.503 Q9GZY0 NXF2_HUMAN 71.429 0.0167158 3.2492 NXF2 - Nuclear RNA export factor 2 - Homo sapiens (Human) - NXF2 gene Involved in the export of mRNA from the nucleus to the cytoplasm. Indicus|evm.model.CM009520.1.504 Q9H4D5 NXF3_HUMAN 52.312 0.853018 0.717514 NXF3 - Nuclear RNA export factor 3 - Homo sapiens (Human) - NXF3 gene May function as a tissue-specific nuclear mRNA export factor. Indicus|evm.model.CM009520.1.507 A3KGB4 TBC8B_MOUSE 95.570 0.530405 0.265709 Tbc1d8b - TBC1 domain family member 8B - Mus musculus (Mouse) - Tbc1d8b gene Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein. Indicus|evm.model.CM009520.1.508 Q29RU0 RN128_BOVIN 99.768 0.99537 1.00232 RNF128 - E3 ubiquitin-protein ligase RNF128 precursor - Bos taurus (Bovine) - RNF128 gene E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. Indicus|evm.model.CM009520.1.509 Q6NSI4 RADX_HUMAN 71.329 0.997516 0.94152 RADX - RPA-related protein RADX - Homo sapiens (Human) - RADX gene Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897). Indicus|evm.model.CM009520.1.510 Q2TBV0 BEX2_BOVIN 82.031 0.984496 1.00781 BEX2 - Protein BEX2 - Bos taurus (Bovine) - BEX2 gene Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity). Indicus|evm.model.CM009520.1.511 Q3ZBJ6 BEX3_BOVIN 100.000 0.982301 1.00893 BEX3 - Protein BEX3 - Bos taurus (Bovine) - BEX3 gene May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). Indicus|evm.model.CM009520.1.512 Q9H4D5 NXF3_HUMAN 50.775 0.965451 0.981168 NXF3 - Nuclear RNA export factor 3 - Homo sapiens (Human) - NXF3 gene May function as a tissue-specific nuclear mRNA export factor. Indicus|evm.model.CM009520.1.513 Q9NWD9 BEX4_HUMAN 65.833 0.983471 1.00833 BEX4 - Protein BEX4 - Homo sapiens (Human) - BEX4 gene May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability. Indicus|evm.model.CM009520.1.514 Q3T020 TCAL8_BOVIN 100.000 0.983051 1.00855 TCEAL8 - Transcription elongation factor A protein-like 8 - Bos taurus (Bovine) - TCEAL8 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.516 B2RYR0 RN168_RAT 65.854 0.536424 0.26773 Rnf168 - E3 ubiquitin-protein ligase RNF168 - Rattus norvegicus (Rat) - Rnf168 gene E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). Indicus|evm.model.CM009520.1.517 Q0IIM1 RN168_BOVIN 80.952 0.369369 0.193717 RNF168 - E3 ubiquitin-protein ligase RNF168 - Bos taurus (Bovine) - RNF168 gene E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). Indicus|evm.model.CM009520.1.518 P62828 RAN_RAT 96.094 0.984496 0.597222 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Indicus|evm.model.CM009520.1.519 Q8MIK9 PP14B_PIG 87.603 0.794702 1.02721 PPP1R14B - Protein phosphatase 1 regulatory subunit 14B - Sus scrofa (Pig) - PPP1R14B gene Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). Indicus|evm.model.CM009520.1.520 Q96EI5 TCAL4_HUMAN 62.882 0.866412 1.2186 TCEAL4 - Transcription elongation factor A protein-like 4 - Homo sapiens (Human) - TCEAL4 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.521 Q2KIJ9 TCAL1_BOVIN 99.371 0.9875 1.00629 TCEAL1 - Transcription elongation factor A protein-like 1 - Bos taurus (Bovine) - TCEAL1 gene May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity). Indicus|evm.model.CM009520.1.522 Q5R905 MO4L2_PONAB 96.181 0.993056 1 MORF4L2 - Mortality factor 4-like protein 2 - Pongo abelii (Sumatran orangutan) - MORF4L2 gene Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity). Indicus|evm.model.CM009520.1.523 Q61603 GLRA4_MOUSE 97.248 0.956044 0.997807 Glra4 - Glycine receptor subunit alpha-4 precursor - Mus musculus (Mouse) - Glra4 gene Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine (PubMed:10762330). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (Probable). Indicus|evm.model.CM009520.1.524 P04116 MYPR_BOVIN 100.000 0.992806 1.00361 PLP1 - Myelin proteolipid protein - Bos taurus (Bovine) - PLP1 gene This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. Indicus|evm.model.CM009520.1.525 Q5R4W9 RAB9B_PONAB 99.502 0.990099 1.00498 RAB9B - Ras-related protein Rab-9B - Pongo abelii (Sumatran orangutan) - RAB9B gene Involved in the transport of proteins between the endosomes and the trans Golgi network. Indicus|evm.model.CM009520.1.526 P0C1H6 H2BFM_HUMAN 52.222 0.453125 1.24675 H2BW2 - Histone H2B type F-M - Homo sapiens (Human) - H2BW2 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009520.1.528 P22314 UBA1_HUMAN 68.041 0.22093 0.406427 UBA1 - Ubiquitin-like modifier-activating enzyme 1 - Homo sapiens (Human) - UBA1 gene Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). Indicus|evm.model.CM009520.1.530 Q7Z2G1 H2BWT_HUMAN 46.457 0.706587 0.954286 H2BW1 - Histone H2B type W-T - Homo sapiens (Human) - H2BW1 gene Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function. Indicus|evm.model.CM009520.1.531 Q7Z2G1 H2BWT_HUMAN 46.457 0.706587 0.954286 H2BW1 - Histone H2B type W-T - Homo sapiens (Human) - H2BW1 gene Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function. Indicus|evm.model.CM009520.1.532 Q7Z2G1 H2BWT_HUMAN 46.457 0.900763 0.748571 H2BW1 - Histone H2B type W-T - Homo sapiens (Human) - H2BW1 gene Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function. Indicus|evm.model.CM009520.1.533 P70696 H2B1A_MOUSE 54.464 0.670732 1.29134 H2bc1 - Histone H2B type 1-A - Mus musculus (Mouse) - H2bc1 gene Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (PubMed:23884607, PubMed:28366643). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (PubMed:23884607). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (PubMed:23884607). Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009520.1.534 Q86YH2 Z280B_HUMAN 52.439 0.851648 0.335175 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Indicus|evm.model.CM009520.1.535 Q86YH2 Z280B_HUMAN 70.784 0.676948 1.13444 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Indicus|evm.model.CM009520.1.536 O19110 TSPY1_BOVIN 95.506 0.360656 0.769716 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009520.1.537 Q5H9E4 S2553_HUMAN 91.148 0.990228 1 SLC25A53 - Solute carrier family 25 member 53 - Homo sapiens (Human) - SLC25A53 gene Indicus|evm.model.CM009520.1.538 Q08DL1 ZCH12_BOVIN 70.811 0.980892 0.390547 ZCCHC12 - Zinc finger CCHC domain-containing protein 12 - Bos taurus (Bovine) - ZCCHC12 gene Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity). Indicus|evm.model.CM009520.1.539 Q6PEV8 F199X_HUMAN 98.454 0.994859 1.00258 FAM199X - Protein FAM199X - Homo sapiens (Human) - FAM199X gene Indicus|evm.model.CM009520.1.540 Q26602 SMOX3_SCHMA 60.938 0.225 0.972222 SMOX-3 - Homeobox protein SMOX-3 - Schistosoma mansoni (Blood fluke) - SMOX-3 gene Indicus|evm.model.CM009520.1.542 Q9BE31 RHG12_MACFA 83.750 0.44382 0.210153 ARHGAP12 - Rho GTPase-activating protein 12 - Macaca fascicularis (Crab-eating macaque) - ARHGAP12 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Indicus|evm.model.CM009520.1.545 Q9EQZ1 T22D3_RAT 96.396 0.709677 1.15672 Tsc22d3 - TSC22 domain family protein 3 - Rattus norvegicus (Rat) - Tsc22d3 gene Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity). Indicus|evm.model.CM009520.1.547 P60892 PRPS1_RAT 100.000 0.99373 1.00314 Prps1 - Ribose-phosphate pyrophosphokinase 1 - Rattus norvegicus (Rat) - Prps1 gene Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Indicus|evm.model.CM009520.1.548 Q5JV73 FRPD3_HUMAN 89.939 0.974273 0.987845 FRMPD3 - FERM and PDZ domain-containing protein 3 - Homo sapiens (Human) - FRMPD3 gene plasma membrane, secretory granule membrane, tertiary granule membrane, neutrophil degranulation Indicus|evm.model.CM009520.1.549 Q8TE76 MORC4_HUMAN 87.600 0.989819 0.943436 MORC4 - MORC family CW-type zinc finger protein 4 - Homo sapiens (Human) - MORC4 gene Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). Indicus|evm.model.CM009520.1.550 Q765P1 CLD2_BOVIN 100.000 0.991342 1.00435 CLDN2 - Claudin-2 - Bos taurus (Bovine) - CLDN2 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009520.1.551 Q0D2K3 RIPP1_HUMAN 80.247 0.418848 1.2649 RIPPLY1 - Protein ripply1 - Homo sapiens (Human) - RIPPLY1 gene Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity). Indicus|evm.model.CM009520.1.552 Q0IIM8 TBC8B_HUMAN 90.403 0.988981 0.648214 TBC1D8B - TBC1 domain family member 8B - Homo sapiens (Human) - TBC1D8B gene Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein. Indicus|evm.model.CM009520.1.553 Q9NQM4 DAAF6_HUMAN 69.048 0.794574 1.20561 DNAAF6 - Dynein axonemal assembly factor 6 - Homo sapiens (Human) - DNAAF6 gene Plays a role in cytoplasmic pre-assembly of axonemal dynein. Indicus|evm.model.CM009520.1.554 Q9H1M0 N62CL_HUMAN 65.000 0.455738 1.65761 NUP62CL - Nucleoporin-62 C-terminal-like protein - Homo sapiens (Human) - NUP62CL gene nuclear pore central transport channel, phospholipid binding, structural constituent of nuclear pore, protein import into nucleus, RNA export from nucleus Indicus|evm.model.CM009520.1.555 Q96IZ5 RBM41_HUMAN 99.057 0.302594 0.840194 RBM41 - RNA-binding protein 41 - Homo sapiens (Human) - RBM41 gene May bind RNA. Indicus|evm.model.CM009520.1.556 Q9QUS6 TRIM1_MOUSE 99.349 0.995671 0.655319 Mid2 - Probable E3 ubiquitin-protein ligase MID2 - Mus musculus (Mouse) - Mid2 gene May play a role in microtubule stabilization. Indicus|evm.model.CM009520.1.557 Q9BXU3 TX13A_HUMAN 76.238 0.757576 0.322738 TEX13A - Testis-expressed protein 13A - Homo sapiens (Human) - TEX13A gene Indicus|evm.model.CM009520.1.558 Q29RR6 VSIG1_BOVIN 99.476 0.994778 1.00262 VSIG1 - V-set and immunoglobulin domain-containing protein 1 precursor - Bos taurus (Bovine) - VSIG1 gene basolateral plasma membrane, maintenance of gastrointestinal epithelium Indicus|evm.model.CM009520.1.559 O75832 PSD10_HUMAN 99.111 0.82963 1.19469 PSMD10 - 26S proteasome non-ATPase regulatory subunit 10 - Homo sapiens (Human) - PSMD10 gene Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Indicus|evm.model.CM009520.1.560 Q6PZ05 ATG4A_BOVIN 99.749 0.994987 1.00251 ATG4A - Cysteine protease ATG4A - Bos taurus (Bovine) - ATG4A gene Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity). Indicus|evm.model.CM009520.1.561 Q14031 CO4A6_HUMAN 80.275 0.978672 0.970432 COL4A6 - Collagen alpha-6(IV) chain precursor - Homo sapiens (Human) - COL4A6 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Indicus|evm.model.CM009520.1.562 P25915 FRIH_RABIT 60.748 0.929825 0.695122 FTH1 - Ferritin heavy chain - Oryctolagus cuniculus (Rabbit) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.563 Q08DY6 E2F6_BOVIN 56.690 0.975779 1.01404 E2F6 - Transcription factor E2F6 - Bos taurus (Bovine) - E2F6 gene Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains (By similarity). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (By similarity). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity). Indicus|evm.model.CM009520.1.564 Q28247 CO4A5_CANLF 92.488 0.998782 0.971023 COL4A5 - Collagen alpha-5(IV) chain precursor - Canis lupus familiaris (Dog) - COL4A5 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Indicus|evm.model.CM009520.1.565 O14654 IRS4_HUMAN 89.773 0.364921 0.957041 IRS4 - Insulin receptor substrate 4 - Homo sapiens (Human) - IRS4 gene Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. Indicus|evm.model.CM009520.1.566 P62902 RL31_RAT 86.400 0.984 1 Rpl31 - 60S ribosomal protein L31 - Rattus norvegicus (Rat) - Rpl31 gene cytosolic large ribosomal subunit, nucleolus, nucleoplasm, polysomal ribosome, synapse, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009520.1.567 P0C1H6 H2BFM_HUMAN 49.606 0.619289 1.27922 H2BW2 - Histone H2B type F-M - Homo sapiens (Human) - H2BW2 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009520.1.568 O02740 GUC2F_BOVIN 99.451 0.99817 0.990934 GUCY2F - Retinal guanylyl cyclase 2 precursor - Bos taurus (Bovine) - GUCY2F gene Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:9571173, PubMed:9175772). Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:9571173, PubMed:9175772). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). Indicus|evm.model.CM009520.1.569 A6QNX3 NXT2_BOVIN 100.000 0.986014 1.00704 NXT2 - NTF2-related export protein 2 - Bos taurus (Bovine) - NXT2 gene Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (By similarity). Indicus|evm.model.CM009520.1.570 Q9UJ90 KCNE5_HUMAN 79.845 0.735632 1.22535 KCNE5 - Potassium voltage-gated channel subfamily E regulatory beta subunit 5 - Homo sapiens (Human) - KCNE5 gene Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. Indicus|evm.model.CM009520.1.571 O60488 ACSL4_HUMAN 96.062 0.997191 1.00141 ACSL4 - Long-chain-fatty-acid--CoA ligase 4 - Homo sapiens (Human) - ACSL4 gene Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590). Indicus|evm.model.CM009520.1.572 O46414 FRIH_BOVIN 80.347 0.986207 0.801105 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.574 Q5JUK9 PAGE3_HUMAN 53.333 0.717742 1.09735 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Indicus|evm.model.CM009520.1.575 Q5U3C3 TM164_HUMAN 97.980 0.993289 1.00337 TMEM164 - Transmembrane protein 164 - Homo sapiens (Human) - TMEM164 gene Indicus|evm.model.CM009520.1.576 Q9Y4X0 AMMR1_HUMAN 98.662 0.577519 1.54955 AMMECR1 - AMME syndrome candidate gene 1 protein - Homo sapiens (Human) - AMMECR1 gene mitochondrion, nucleoplasm, nucleus Indicus|evm.model.CM009520.1.577 Q8NET4 RTL9_HUMAN 67.655 0.981402 1.0072 RTL9 - Retrotransposon Gag-like protein 9 - Homo sapiens (Human) - RTL9 gene Indicus|evm.model.CM009520.1.578 P0C1H6 H2BFM_HUMAN 43.448 0.856287 1.08442 H2BW2 - Histone H2B type F-M - Homo sapiens (Human) - H2BW2 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009520.1.579 Q9BU40 CRDL1_HUMAN 97.400 0.995283 0.929825 CHRDL1 - Chordin-like protein 1 precursor - Homo sapiens (Human) - CHRDL1 gene Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. Indicus|evm.model.CM009520.1.584 Q62829 PAK3_RAT 99.081 0.99633 1.00184 Pak3 - Serine/threonine-protein kinase PAK 3 - Rattus norvegicus (Rat) - Pak3 gene Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development (PubMed:12890786). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Indicus|evm.model.CM009520.1.585 Q9Y6Q1 CAN6_HUMAN 94.228 0.996885 1.00156 CAPN6 - Calpain-6 - Homo sapiens (Human) - CAPN6 gene Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). Indicus|evm.model.CM009520.1.586 O43602 DCX_HUMAN 98.082 0.99446 0.989041 DCX - Neuronal migration protein doublecortin - Homo sapiens (Human) - DCX gene Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. Indicus|evm.model.CM009520.1.587 P52301 RAN_XENLA 87.755 0.655405 0.685185 ran - GTP-binding nuclear protein Ran - Xenopus laevis (African clawed frog) - ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:8413630). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446). Required for normal progress through mitosis (By similarity). In concert with nemp1a/b, required for proper eye development (PubMed:25946333). Indicus|evm.model.CM009520.1.588 P31625 PRO_JSRV 48.175 0.92629 0.469977 pro - Gag-Pro polyprotein - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - pro gene Matrix protein. Indicus|evm.model.CM009520.1.589 Q5I0K7 ALG13_RAT 85.455 0.987952 1.00606 Alg13 - UDP-N-acetylglucosamine transferase subunit ALG13 homolog - Rattus norvegicus (Rat) - Alg13 gene May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway. Indicus|evm.model.CM009520.1.590 Q9NP73 ALG13_HUMAN 84.525 0.997809 0.80299 ALG13 - Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 - Homo sapiens (Human) - ALG13 gene Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities. Indicus|evm.model.CM009520.1.591 O62852 TRPC5_RABIT 96.142 0.969118 0.698152 TRPC5 - Short transient receptor potential channel 5 - Oryctolagus cuniculus (Rabbit) - TRPC5 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion (By similarity). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Indicus|evm.model.CM009520.1.592 A6NMA1 TR5OS_HUMAN 61.111 0.954955 1 TRPC5OS - Putative uncharacterized protein TRPC5OS - Homo sapiens (Human) - TRPC5OS gene Indicus|evm.model.CM009520.1.593 Q9UL62 TRPC5_HUMAN 99.668 0.946372 0.325797 TRPC5 - Short transient receptor potential channel 5 - Homo sapiens (Human) - TRPC5 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Indicus|evm.model.CM009520.1.594 Q6ZR62 RTL4_HUMAN 65.868 0.988095 0.541935 RTL4 - Retrotransposon Gag-like protein 4 - Homo sapiens (Human) - RTL4 gene Involved in cognitive function in the brain, possibly via the noradrenergic system. Indicus|evm.model.CM009520.1.595 Q6ZR62 RTL4_HUMAN 52.976 0.987013 0.496774 RTL4 - Retrotransposon Gag-like protein 4 - Homo sapiens (Human) - RTL4 gene Involved in cognitive function in the brain, possibly via the noradrenergic system. Indicus|evm.model.CM009520.1.596 P19858 LDHA_BOVIN 99.398 0.993994 1.00301 LDHA - L-lactate dehydrogenase A chain - Bos taurus (Bovine) - LDHA gene L-lactate dehydrogenase activity Indicus|evm.model.CM009520.1.597 P16858 G3P_MOUSE 72.340 0.821429 0.168168 Gapdh - Glyceraldehyde-3-phosphate dehydrogenase - Mus musculus (Mouse) - Gapdh gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:19903941). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:19903941). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Indicus|evm.model.CM009520.1.600 Q60F97 5HT2C_CANLF 92.722 0.993671 0.689956 HTR2C - 5-hydroxytryptamine receptor 2C precursor - Canis lupus familiaris (Dog) - HTR2C gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis (By similarity). Indicus|evm.model.CM009520.1.601 Q9Y388 RBMX2_HUMAN 77.509 0.870091 1.02795 RBMX2 - RNA-binding motif protein, X-linked 2 - Homo sapiens (Human) - RBMX2 gene Involved in pre-mRNA splicing as component of the activated spliceosome. Indicus|evm.model.CM009520.1.602 Q5CZC0 FSIP2_HUMAN 54.545 0.990385 0.0301144 FSIP2 - Fibrous sheath-interacting protein 2 - Homo sapiens (Human) - FSIP2 gene Plays a role in spermatogenesis. Indicus|evm.model.CM009520.1.604 Q6ZR62 RTL4_HUMAN 52.976 0.987013 0.496774 RTL4 - Retrotransposon Gag-like protein 4 - Homo sapiens (Human) - RTL4 gene Involved in cognitive function in the brain, possibly via the noradrenergic system. Indicus|evm.model.CM009520.1.605 Q6ZR62 RTL4_HUMAN 51.205 0.847458 0.570968 RTL4 - Retrotransposon Gag-like protein 4 - Homo sapiens (Human) - RTL4 gene Involved in cognitive function in the brain, possibly via the noradrenergic system. Indicus|evm.model.CM009520.1.606 Q80WE5 LHPL1_RAT 96.610 0.966667 0.272727 Lhfpl1 - LHFPL tetraspan subfamily member 1 protein precursor - Rattus norvegicus (Rat) - Lhfpl1 gene membrane Indicus|evm.model.CM009520.1.608 Q4VCS5 AMOT_HUMAN 95.923 0.810185 0.99631 AMOT - Angiomotin - Homo sapiens (Human) - AMOT gene Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Indicus|evm.model.CM009520.1.609 P48763 SL9A2_RAT 70.205 0.554913 0.638376 Slc9a2 - Sodium/hydrogen exchanger 2 - Rattus norvegicus (Rat) - Slc9a2 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption. Indicus|evm.model.CM009520.1.610 O43829 ZBT14_HUMAN 57.616 0.572062 1.00445 ZBTB14 - Zinc finger and BTB domain-containing protein 14 - Homo sapiens (Human) - ZBTB14 gene Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. Indicus|evm.model.CM009520.1.612 P02316 HMGN1_BOVIN 66.667 0.847619 1.0396 HMGN1 - Non-histone chromosomal protein HMG-14 - Bos taurus (Bovine) - HMGN1 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). Indicus|evm.model.CM009520.1.613 Q9UK32 KS6A6_HUMAN 96.523 0.858852 1.12215 RPS6KA6 - Ribosomal protein S6 kinase alpha-6 - Homo sapiens (Human) - RPS6KA6 gene Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. Indicus|evm.model.CM009520.1.614 F1MNN4 FBXW7_BOVIN 76.203 0.994382 0.504249 FBXW7 - F-box/WD repeat-containing protein 7 - Bos taurus (Bovine) - FBXW7 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (By similarity). Indicus|evm.model.CM009520.1.615 P35662 CYLC1_BOVIN 99.546 0.996979 0.992504 CYLC1 - Cylicin-1 - Bos taurus (Bovine) - CYLC1 gene Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. Indicus|evm.model.CM009520.1.617 Q58DU7 SH3L1_BOVIN 100.000 0.982609 1.00877 SH3BGRL - SH3 domain-binding glutamic acid-rich-like protein - Bos taurus (Bovine) - SH3BGRL gene Indicus|evm.model.CM009520.1.618 Q9JL35 HMGN5_MOUSE 62.205 0.416667 0.738916 Hmgn5 - High mobility group nucleosome-binding domain-containing protein 5 - Mus musculus (Mouse) - Hmgn5 gene Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. Indicus|evm.model.CM009520.1.619 Q6RI45 BRWD3_HUMAN 89.474 0.752 0.0693674 BRWD3 - Bromodomain and WD repeat-containing protein 3 - Homo sapiens (Human) - BRWD3 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Indicus|evm.model.CM009520.1.620 Q6RI45 BRWD3_HUMAN 95.831 0.998774 0.905105 BRWD3 - Bromodomain and WD repeat-containing protein 3 - Homo sapiens (Human) - BRWD3 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Indicus|evm.model.CM009520.1.622 Q6AYE4 VATC2_RAT 63.171 0.99375 0.752941 Atp6v1c2 - V-type proton ATPase subunit C 2 - Rattus norvegicus (Rat) - Atp6v1c2 gene Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Indicus|evm.model.CM009520.1.623 A7E3Q8 PLST_BOVIN 100.000 0.99683 1.00159 PLS3 - Plastin-3 - Bos taurus (Bovine) - PLS3 gene Actin-bundling protein. Indicus|evm.model.CM009520.1.625 Q9NUJ7 PLCX1_HUMAN 59.690 0.876712 0.452012 PLCXD1 - PI-PLC X domain-containing protein 1 - Homo sapiens (Human) - PLCXD1 gene Indicus|evm.model.CM009520.1.628 O19110 TSPY1_BOVIN 51.136 0.353659 0.776025 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009520.1.629 Q9CRB3 HIUH_MOUSE 67.442 0.211055 1.68644 Urah - 5-hydroxyisourate hydrolase - Mus musculus (Mouse) - Urah gene Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). Indicus|evm.model.CM009520.1.630 Q5VUJ6 LRCH2_HUMAN 99.237 0.984848 0.172549 LRCH2 - Leucine-rich repeat and calponin homology domain-containing protein 2 - Homo sapiens (Human) - LRCH2 gene May play a role in the organization of the cytoskeleton. Indicus|evm.model.CM009520.1.631 Q96NX9 DACH2_HUMAN 91.765 0.695473 0.405676 DACH2 - Dachshund homolog 2 - Homo sapiens (Human) - DACH2 gene Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain. Indicus|evm.model.CM009520.1.632 Q925Q8 DACH2_MOUSE 98.000 0.98 0.0788644 Dach2 - Dachshund homolog 2 - Mus musculus (Mouse) - Dach2 gene Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain. Indicus|evm.model.CM009520.1.633 P49335 PO3F4_HUMAN 96.143 0.994505 1.00831 POU3F4 - POU domain, class 3, transcription factor 4 - Homo sapiens (Human) - POU3F4 gene Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain. Indicus|evm.model.CM009520.1.634 Q9UQ26 RIMS2_HUMAN 93.860 0.982609 0.0815025 RIMS2 - Regulating synaptic membrane exocytosis protein 2 - Homo sapiens (Human) - RIMS2 gene Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). Indicus|evm.model.CM009520.1.636 P24386 RAE1_HUMAN 88.050 0.99686 0.975498 CHM - Rab proteins geranylgeranyltransferase component A 1 - Homo sapiens (Human) - CHM gene Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. Indicus|evm.model.CM009520.1.637 O46415 FRIL_BOVIN 87.013 0.844444 0.514286 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.639 Q8VH49 HIG1A_RAT 87.097 0.978723 1.01075 Higd1a - HIG1 domain family member 1A, mitochondrial - Rattus norvegicus (Rat) - Higd1a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Indicus|evm.model.CM009520.1.640 Q8WVV4 POF1B_HUMAN 86.250 0.88764 0.151104 POF1B - Protein POF1B - Homo sapiens (Human) - POF1B gene Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. Indicus|evm.model.CM009520.1.641 Q9Y462 ZN711_HUMAN 97.635 0.997375 1.00131 ZNF711 - Zinc finger protein 711 - Homo sapiens (Human) - ZNF711 gene Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C. Indicus|evm.model.CM009520.1.642 Q86VE3 SATL1_HUMAN 70.992 0.992248 0.371223 SATL1 - Spermidine/spermine N(1)-acetyltransferase-like protein 1 - Homo sapiens (Human) - SATL1 gene N-acetyltransferase activity Indicus|evm.model.CM009520.1.643 Q3SZ27 MIC27_BOVIN 99.621 0.992453 1.00379 APOL - MICOS complex subunit MIC27 precursor - Bos taurus (Bovine) - APOL gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. Indicus|evm.model.CM009520.1.648 Q8NEK8 TET5D_HUMAN 80.977 0.992327 1.00514 TENT5D - Terminal nucleotidyltransferase 5D - Homo sapiens (Human) - TENT5D gene Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase. Indicus|evm.model.CM009520.1.650 Q8NI27 THOC2_HUMAN 85.276 0.818182 0.124294 THOC2 - THO complex subunit 2 - Homo sapiens (Human) - THOC2 gene Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. Indicus|evm.model.CM009520.1.652 Q9Y458 TBX22_HUMAN 79.885 0.996109 0.988462 TBX22 - T-box transcription factor TBX22 - Homo sapiens (Human) - TBX22 gene Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. Indicus|evm.model.CM009520.1.653 Q7Z353 HDX_HUMAN 88.219 0.978495 0.53913 HDX - Highly divergent homeobox - Homo sapiens (Human) - HDX gene chromatin, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009520.1.654 Q3SYR7 RL9_BOVIN 97.917 0.989637 1.00521 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009520.1.655 Q9BXC1 GP174_HUMAN 89.790 0.994012 1.003 GPR174 - Probable G-protein coupled receptor 174 - Homo sapiens (Human) - GPR174 gene Putative receptor for purines coupled to G-proteins. Indicus|evm.model.CM009520.1.656 Q9P2Y5 UVRAG_HUMAN 66.468 0.880597 0.670959 UVRAG - UV radiation resistance-associated gene protein - Homo sapiens (Human) - UVRAG gene Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). Indicus|evm.model.CM009520.1.657 O00398 P2Y10_HUMAN 89.329 0.993921 0.970501 P2RY10 - Putative P2Y purinoceptor 10 - Homo sapiens (Human) - P2RY10 gene Putative receptor for purines coupled to G-proteins. Indicus|evm.model.CM009520.1.658 Q8BLG2 LPAR4_MOUSE 98.378 0.994609 1.0027 Lpar4 - Lysophosphatidic acid receptor 4 - Mus musculus (Mouse) - Lpar4 gene Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA (By similarity). Indicus|evm.model.CM009520.1.660 Q6DFV6 FN3C1_MOUSE 57.447 0.997059 1.00295 Fndc3c1 - Fibronectin type III domain containing protein 3C1 - Mus musculus (Mouse) - Fndc3c1 gene Indicus|evm.model.CM009520.1.661 Q5R7P7 TAF9B_PONAB 95.219 0.992063 1.00398 TAF9B - Transcription initiation factor TFIID subunit 9B - Pongo abelii (Sumatran orangutan) - TAF9B gene Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity). Indicus|evm.model.CM009520.1.662 Q3T0P6 PGK1_BOVIN 99.510 0.99511 0.980815 PGK1 - Phosphoglycerate kinase 1 - Bos taurus (Bovine) - PGK1 gene Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. Indicus|evm.model.CM009520.1.663 Q6R5N8 TLR13_MOUSE 78.363 0.944444 0.181635 Tlr13 - Toll-like receptor 13 precursor - Mus musculus (Mouse) - Tlr13 gene Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences. Indicus|evm.model.CM009520.1.664 Q04656 ATP7A_HUMAN 92.600 0.998668 1.00067 ATP7A - Copper-transporting ATPase 1 - Homo sapiens (Human) - ATP7A gene ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:31283225, PubMed:28389643). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:28389643, PubMed:11092760). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (PubMed:28389643) (By similarity). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). Indicus|evm.model.CM009520.1.665 Q5E954 DNJA1_BOVIN 99.748 0.994975 1.00252 DNAJA1 - DnaJ homolog subfamily A member 1 precursor - Bos taurus (Bovine) - DNAJA1 gene Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Indicus|evm.model.CM009520.1.666 P13183 COX7B_BOVIN 100.000 0.975309 1.0125 COX7B - Cytochrome c oxidase subunit 7B, mitochondrial precursor - Bos taurus (Bovine) - COX7B gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (PubMed:27605664). Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity). Indicus|evm.model.CM009520.1.667 Q9H0U3 MAGT1_HUMAN 98.758 0.993808 0.964179 MAGT1 - Magnesium transporter protein 1 precursor - Homo sapiens (Human) - MAGT1 gene Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Indicus|evm.model.CM009520.1.668 Q7YQM4 ATRX_PANTR 89.735 0.999193 0.994783 ATRX - Transcriptional regulator ATRX - Pan troglodytes (Chimpanzee) - ATRX gene Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. May be involved in transcriptional regulation of telomeric repeat-containing RNA (TERRA). Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (By similarity). Indicus|evm.model.CM009520.1.669 Q9ESL8 FGF16_MOUSE 99.517 0.990385 1.00483 Fgf16 - Fibroblast growth factor 16 - Mus musculus (Mouse) - Fgf16 gene Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Indicus|evm.model.CM009520.1.670 Q93079 H2B1H_HUMAN 88.571 0.945205 0.579365 H2BC9 - Histone H2B type 1-H - Homo sapiens (Human) - H2BC9 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009520.1.672 Q6RI85 PGK2_PIG 83.333 0.625 0.134293 PGK2 - Phosphoglycerate kinase 2 - Sus scrofa (Pig) - PGK2 gene Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis. Indicus|evm.model.CM009520.1.673 Q5RDE1 IF2P_PONAB 72.088 0.987437 0.32623 EIF5B - Eukaryotic translation initiation factor 5B - Pongo abelii (Sumatran orangutan) - EIF5B gene Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. Indicus|evm.model.CM009520.1.674 O60841 IF2P_HUMAN 97.783 0.980392 0.37623 EIF5B - Eukaryotic translation initiation factor 5B - Homo sapiens (Human) - EIF5B gene Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. Indicus|evm.model.CM009520.1.675 Q9D0B6 PBDC1_MOUSE 79.293 0.877273 1.11111 Pbdc1 - Protein PBDC1 - Mus musculus (Mouse) - Pbdc1 gene Indicus|evm.model.CM009520.1.676 Q8TD90 MAGE2_HUMAN 86.973 0.994275 1.00191 MAGEE2 - Melanoma-associated antigen E2 - Homo sapiens (Human) - MAGEE2 gene Indicus|evm.model.CM009520.1.677 P31622 GAG_JSRV 76.860 0.267261 0.73366 gag - Gag polyprotein - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - gag gene Matrix protein. Indicus|evm.model.CM009520.1.678 Q96MV8 ZDH15_HUMAN 97.626 0.994083 1.00297 ZDHHC15 - Palmitoyltransferase ZDHHC15 - Homo sapiens (Human) - ZDHHC15 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:18817523, PubMed:23034182). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (PubMed:18817523). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (PubMed:18817523). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis (By similarity). Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity). Could also catalyze the palmitoylation of GAP43 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate FYN as shown in vitro (PubMed:19956733). Indicus|evm.model.CM009520.1.679 Q32LA4 UPP_BOVIN 99.673 0.993485 1.00327 UPRT - Uracil phosphoribosyltransferase homolog - Bos taurus (Bovine) - UPRT gene Indicus|evm.model.CM009520.1.680 P52293 IMA1_MOUSE 69.398 0.78373 0.952741 Kpna2 - Importin subunit alpha-1 - Mus musculus (Mouse) - Kpna2 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Indicus|evm.model.CM009520.1.681 O75027 ABCB7_HUMAN 93.484 0.997344 1.00133 ABCB7 - Iron-sulfur clusters transporter ABCB7, mitochondrial precursor - Homo sapiens (Human) - ABCB7 gene Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins, in turns participates in iron homeostasis (PubMed:33157103, PubMed:17192393, PubMed:10196363). Moreover through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity). Indicus|evm.model.CM009520.1.682 Q5RDL6 EID1_PONAB 66.406 0.942149 0.643617 EID1 - EP300-interacting inhibitor of differentiation 1 - Pongo abelii (Sumatran orangutan) - EID1 gene Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms (By similarity). Indicus|evm.model.CM009520.1.683 Q5QGS0 NEXMI_HUMAN 90.646 0.998653 0.979551 NEXMIF - Neurite extension and migration factor - Homo sapiens (Human) - NEXMIF gene Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1). Indicus|evm.model.CM009520.1.684 Q9NVW2 RNF12_HUMAN 92.480 0.968254 1.00962 RLIM - E3 ubiquitin-protein ligase RLIM - Homo sapiens (Human) - RLIM gene E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. Indicus|evm.model.CM009520.1.685 P36021 MOT8_HUMAN 94.697 0.982587 0.745826 SLC16A2 - Monocarboxylate transporter 8 - Homo sapiens (Human) - SLC16A2 gene Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr. Indicus|evm.model.CM009520.1.686 P36021 MOT8_HUMAN 84.615 0.913907 0.280148 SLC16A2 - Monocarboxylate transporter 8 - Homo sapiens (Human) - SLC16A2 gene Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr. Indicus|evm.model.CM009520.1.688 Q8WW36 ZCH13_HUMAN 69.863 0.843023 1.03614 ZCCHC13 - Zinc finger CCHC domain-containing protein 13 - Homo sapiens (Human) - ZCCHC13 gene cytoplasm, mRNA binding, single-stranded RNA binding, translation regulator activity, positive regulation of cytoplasmic translation Indicus|evm.model.CM009520.1.690 P04394 NDUV2_BOVIN 98.551 0.944954 0.875502 NDUFV2 - NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor - Bos taurus (Bovine) - NDUFV2 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Indicus|evm.model.CM009520.1.691 Q9ES28 ARHG7_MOUSE 79.762 0.132353 0.709977 Arhgef7 - Rho guanine nucleotide exchange factor 7 - Mus musculus (Mouse) - Arhgef7 gene Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). Indicus|evm.model.CM009520.1.692 Q5VXU3 CHIC1_HUMAN 97.333 0.99115 1.00893 CHIC1 - Cysteine-rich hydrophobic domain-containing protein 1 - Homo sapiens (Human) - CHIC1 gene Indicus|evm.model.CM009520.1.693 O14627 CDX4_HUMAN 85.971 0.992806 0.978873 CDX4 - Homeobox protein CDX-4 - Homo sapiens (Human) - CDX4 gene chromatin, nucleus, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, animal organ morphogenesis, anterior/posterior axis specification Indicus|evm.model.CM009520.1.694 Q5HYR2 DMRTC_HUMAN 64.407 0.246809 1.22396 DMRTC1 - Doublesex- and mab-3-related transcription factor C1 - Homo sapiens (Human) - DMRTC1 gene chromatin, nucleus Indicus|evm.model.CM009520.1.695 Q5JQF8 PAP1M_HUMAN 98.370 0.989189 0.925 PABPC1L2A - Polyadenylate-binding protein 1-like 2 - Homo sapiens (Human) - PABPC1L2A gene extracellular exosome Indicus|evm.model.CM009520.1.696 Q5JQF8 PAP1M_HUMAN 99.000 0.518229 1.92 PABPC1L2A - Polyadenylate-binding protein 1-like 2 - Homo sapiens (Human) - PABPC1L2A gene extracellular exosome Indicus|evm.model.CM009520.1.697 P62630 EF1A1_RAT 85.093 0.987654 0.350649 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009520.1.698 P62630 EF1A1_RAT 86.243 0.989474 0.411255 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Indicus|evm.model.CM009520.1.699 P46020 KPB1_HUMAN 94.195 0.998348 0.990188 PHKA1 - Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform - Homo sapiens (Human) - PHKA1 gene Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. Indicus|evm.model.CM009520.1.700 Q0VCB2 HDAC8_BOVIN 99.735 0.841163 1.18568 HDAC8 - Histone deacetylase 8 - Bos taurus (Bovine) - HDAC8 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility (By similarity). Indicus|evm.model.CM009520.1.702 Q9BDI3 CITE1_BOVIN 100.000 0.754864 1.31795 CITED1 - Cbp/p300-interacting transactivator 1 - Bos taurus (Bovine) - CITED1 gene Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner (By similarity). Indicus|evm.model.CM009520.1.703 P79103 RS4_BOVIN 100.000 0.992424 1.0038 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009520.1.704 A6QQR4 ERC6L_BOVIN 99.919 0.998391 1.00081 ERCC6L - DNA excision repair protein ERCC-6-like - Bos taurus (Bovine) - ERCC6L gene DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). Indicus|evm.model.CM009520.1.705 A6QPY8 PIN4_BOVIN 100.000 0.974359 0.59542 PIN4 - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 - Bos taurus (Bovine) - PIN4 gene Involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA (By similarity). Indicus|evm.model.CM009520.1.706 Q5HYW2 NHSL2_HUMAN 86.287 0.953654 0.915918 NHSL2 - NHS-like protein 2 - Homo sapiens (Human) - NHSL2 gene cell differentiation Indicus|evm.model.CM009520.1.707 Q5HYW3 RTL5_HUMAN 72.775 0.996448 0.989455 RTL5 - Retrotransposon Gag-like protein 5 - Homo sapiens (Human) - RTL5 gene Indicus|evm.model.CM009520.1.709 Q5HYW2 NHSL2_HUMAN 95.522 0.66 0.0816327 NHSL2 - NHS-like protein 2 - Homo sapiens (Human) - NHSL2 gene cell differentiation Indicus|evm.model.CM009520.1.710 A5PKC7 CX049_BOVIN 52.285 0.854962 0.981273 Uncharacterized protein CXorf49 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.711 A5PKC7 CX049_BOVIN 51.295 0.568773 0.503745 Uncharacterized protein CXorf49 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.712 P79103 RS4_BOVIN 73.446 0.985507 0.524715 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009520.1.713 A5PKC7 CX049_BOVIN 92.737 0.996283 1.00749 Uncharacterized protein CXorf49 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.714 A5PKC7 CX049_BOVIN 71.429 0.184685 0.41573 Uncharacterized protein CXorf49 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.715 Q96IR2 ZN845_HUMAN 76.190 0.0995146 0.424742 ZNF845 - Zinc finger protein 845 - Homo sapiens (Human) - ZNF845 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.717 P79103 RS4_BOVIN 94.860 0.968182 0.836502 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009520.1.718 P79103 RS4_BOVIN 95.522 0.980392 0.775665 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Indicus|evm.model.CM009520.1.719 Q6DCE8 CTR2_XENLA 68.478 0.238845 0.61254 slc7a2 - Cationic amino acid transporter 2 - Xenopus laevis (African clawed frog) - slc7a2 gene Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Indicus|evm.model.CM009520.1.720 Q5MD61 CXCR3_BOVIN 100.000 0.99449 0.991803 CXCR3 - C-X-C chemokine receptor type 3 - Bos taurus (Bovine) - CXCR3 gene Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). Indicus|evm.model.CM009520.1.721 Q96QF7 ACRC_HUMAN 59.394 0.631808 0.664255 GCNA - Acidic repeat-containing protein - Homo sapiens (Human) - GCNA gene nucleoplasm, nucleus Indicus|evm.model.CM009520.1.722 P81436 OGT1_RABIT 99.904 0.99809 1.00096 OGT - UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit - Oryctolagus cuniculus (Rabbit) - OGT gene Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue (PubMed:2137449). Acts on cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (By similarity). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues. O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex. Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins ARNTL/BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (By similarity). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Glycosylates HOXA1 (By similarity). O-glycosylates FNIP1 (By similarity). Indicus|evm.model.CM009520.1.723 P21675 TAF1_HUMAN 95.186 0.998953 1.02083 TAF1 - Transcription initiation factor TFIID subunit 1 - Homo sapiens (Human) - TAF1 gene Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300). Indicus|evm.model.CM009520.1.724 P08582 TRFM_HUMAN 95.161 0.554054 0.300813 MELTF - Melanotransferrin precursor - Homo sapiens (Human) - MELTF gene Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. Indicus|evm.model.CM009520.1.725 P84096 RHOG_MOUSE 73.822 0.959596 1.03665 Rhog - Rho-related GTP-binding protein RhoG precursor - Mus musculus (Mouse) - Rhog gene Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity). Indicus|evm.model.CM009520.1.726 Q9UKP3 ITBP2_HUMAN 93.040 0.951049 0.824207 ITGB1BP2 - Integrin beta-1-binding protein 2 - Homo sapiens (Human) - ITGB1BP2 gene May play a role during maturation and/or organization of muscles cells. Indicus|evm.model.CM009520.1.727 Q5RFL9 NONO_PONAB 99.575 0.995754 1 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Indicus|evm.model.CM009520.1.728 Q14202 ZMYM3_HUMAN 97.378 0.998542 1.00146 ZMYM3 - Zinc finger MYM-type protein 3 - Homo sapiens (Human) - ZMYM3 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Indicus|evm.model.CM009520.1.729 O18968 CXB1_BOVIN 100.000 0.992982 1.00352 GJB1 - Gap junction beta-1 protein - Bos taurus (Bovine) - GJB1 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Indicus|evm.model.CM009520.1.730 Q5E9J1 HNRPF_BOVIN 90.141 0.99061 0.514493 HNRNPF - Heterogeneous nuclear ribonucleoprotein F - Bos taurus (Bovine) - HNRNPF gene Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity). Indicus|evm.model.CM009520.1.731 Q9NZ94 NLGN3_HUMAN 99.410 0.997644 1.00118 NLGN3 - Neuroligin-3 precursor - Homo sapiens (Human) - NLGN3 gene Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity). Indicus|evm.model.CM009520.1.732 Q93074 MED12_HUMAN 95.160 0.920391 0.986679 MED12 - Mediator of RNA polymerase II transcription subunit 12 - Homo sapiens (Human) - MED12 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Indicus|evm.model.CM009520.1.733 Q32LJ3 CX065_BOVIN 98.810 0.315094 3.04598 Uncharacterized protein CXorf65 homolog - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.734 P98177 FOXO4_HUMAN 87.891 0.996101 1.01584 FOXO4 - Forkhead box protein O4 - Homo sapiens (Human) - FOXO4 gene Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Indicus|evm.model.CM009520.1.735 Q9UMY4 SNX12_HUMAN 88.272 0.986395 0.907407 SNX12 - Sorting nexin-12 - Homo sapiens (Human) - SNX12 gene May be involved in several stages of intracellular trafficking. Indicus|evm.model.CM009520.1.736 P49666 RL21_PIG 90.000 0.987578 1.00625 RPL21 - 60S ribosomal protein L21 - Sus scrofa (Pig) - RPL21 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009520.1.737 Q8WY07 CTR3_HUMAN 88.710 0.996774 1.00162 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Indicus|evm.model.CM009520.1.738 Q8IYF3 TEX11_HUMAN 64.764 0.990207 0.97766 TEX11 - Testis-expressed protein 11 - Homo sapiens (Human) - TEX11 gene Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. Indicus|evm.model.CM009520.1.739 Q92796 DLG3_HUMAN 89.798 0.741697 1.32681 DLG3 - Disks large homolog 3 - Homo sapiens (Human) - DLG3 gene Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Indicus|evm.model.CM009520.1.740 Q9HCC8 GDPD2_HUMAN 82.189 0.996296 1.00186 GDPD2 - Glycerophosphoinositol inositolphosphodiesterase GDPD2 - Homo sapiens (Human) - GDPD2 gene Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity). Indicus|evm.model.CM009520.1.741 O95239 KIF4A_HUMAN 92.950 0.998381 1.00244 KIF4A - Chromosome-associated kinesin KIF4A - Homo sapiens (Human) - KIF4A gene Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). Indicus|evm.model.CM009520.1.742 Q6QA76 PDZ11_PIG 95.890 0.895062 1.15714 PDZD11 - PDZ domain-containing protein 11 - Sus scrofa (Pig) - PDZD11 gene Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33. Indicus|evm.model.CM009520.1.743 Q9N0H5 ARRC_BOVIN 98.201 0.987277 1.01028 ARR3 - Arrestin-C - Bos taurus (Bovine) - ARR3 gene May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins. Indicus|evm.model.CM009520.1.744 P58826 P2RY4_CRIGR 90.303 0.448087 2.21818 P2RY4 - P2Y purinoceptor 4 - Cricetulus griseus (Chinese hamster) - P2RY4 gene Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Indicus|evm.model.CM009520.1.745 Q58HT5 AWAT1_HUMAN 89.300 0.785714 0.939024 AWAT1 - Acyl-CoA wax alcohol acyltransferase 1 - Homo sapiens (Human) - AWAT1 gene Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15671038). Shows a strong preference for decyl alcohol (C10), with less activity towards C16 and C18 alcohols (PubMed:15671038). Shows a strong preference for saturated acyl-CoAs (PubMed:15671038). Indicus|evm.model.CM009520.1.746 A6QP72 DG2L6_BOVIN 99.703 0.988235 1.0089 DGAT2L6 - Diacylglycerol O-acyltransferase 2-like protein 6 - Bos taurus (Bovine) - DGAT2L6 gene Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters. Indicus|evm.model.CM009520.1.747 P78318 IGBP1_HUMAN 82.544 0.988201 1 IGBP1 - Immunoglobulin-binding protein 1 - Homo sapiens (Human) - IGBP1 gene Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. Indicus|evm.model.CM009520.1.748 Q6IE21 OTU6A_MOUSE 67.123 0.993151 1.0069 Otud6a - OTU domain-containing protein 6A - Mus musculus (Mouse) - Otud6a gene Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains (By similarity). Indicus|evm.model.CM009520.1.749 Q6E1M8 AWAT2_MOUSE 79.819 0.991018 1.003 Awat2 - Acyl-CoA wax alcohol acyltransferase 2 - Mus musculus (Mouse) - Awat2 gene Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donor and acceptor, respectively (PubMed:15220349). Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis-specific retinyl ester synthesis (PubMed:28096191). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13- cis-retinol and all-trans-retinol substrates (By similarity). Indicus|evm.model.CM009520.1.750 Q9BEG5 EDA_BOVIN 94.771 0.625514 0.621483 EDA - Ectodysplasin-A - Bos taurus (Bovine) - EDA gene Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Indicus|evm.model.CM009520.1.751 P62752 RL23A_RAT 98.718 0.974843 1.01923 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Indicus|evm.model.CM009520.1.752 Q9BEG5 EDA_BOVIN 99.248 0.977778 0.345269 EDA - Ectodysplasin-A - Bos taurus (Bovine) - EDA gene Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Indicus|evm.model.CM009520.1.753 A2BDP1 F155B_MOUSE 91.221 0.992366 0.556263 Fam155b - Transmembrane protein FAM155B - Mus musculus (Mouse) - Fam155b gene plasma membrane, calcium ion import across plasma membrane Indicus|evm.model.CM009520.1.754 Q5JUK9 PAGE3_HUMAN 50.526 0.746032 1.11504 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Indicus|evm.model.CM009520.1.755 Q8NG27 PJA1_HUMAN 85.621 0.929664 0.508554 PJA1 - E3 ubiquitin-protein ligase Praja-1 - Homo sapiens (Human) - PJA1 gene Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. Indicus|evm.model.CM009520.1.757 P98172 EFNB1_HUMAN 96.243 0.994236 1.00289 EFNB1 - Ephrin-B1 precursor - Homo sapiens (Human) - EFNB1 gene Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). Indicus|evm.model.CM009520.1.758 Q92502 STAR8_HUMAN 85.801 0.504175 0.936461 STARD8 - StAR-related lipid transfer protein 8 - Homo sapiens (Human) - STARD8 gene Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. Indicus|evm.model.CM009520.1.759 A6QLC6 YIPF6_BOVIN 100.000 0.990826 0.923729 YIPF6 - Protein YIPF6 - Bos taurus (Bovine) - YIPF6 gene May be required for stable YIPF1 and YIPF2 protein expression. Indicus|evm.model.CM009520.1.760 Q7YQL5 OPHN1_PONPY 98.077 0.6375 0.0997506 OPHN1 - Oligophrenin-1 - Pongo pygmaeus (Bornean orangutan) - OPHN1 gene Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). Indicus|evm.model.CM009520.1.761 Q7YQL5 OPHN1_PONPY 80.890 0.983784 0.461347 OPHN1 - Oligophrenin-1 - Pongo pygmaeus (Bornean orangutan) - OPHN1 gene Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). Indicus|evm.model.CM009520.1.762 Q7YQL5 OPHN1_PONPY 91.228 0.994169 0.427681 OPHN1 - Oligophrenin-1 - Pongo pygmaeus (Bornean orangutan) - OPHN1 gene Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). Indicus|evm.model.CM009520.1.763 Q9GKL7 ANDR_PIG 96.250 0.882743 0.504464 AR - Androgen receptor - Sus scrofa (Pig) - AR gene Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Indicus|evm.model.CM009520.1.764 Q9GKL7 ANDR_PIG 89.749 0.996078 0.569196 AR - Androgen receptor - Sus scrofa (Pig) - AR gene Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Indicus|evm.model.CM009520.1.766 Q9HAV5 TNR27_HUMAN 84.615 0.993333 1.0101 EDA2R - Tumor necrosis factor receptor superfamily member 27 - Homo sapiens (Human) - EDA2R gene Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. Indicus|evm.model.CM009520.1.767 Q64336 TBR1_MOUSE 51.295 0.914634 0.240822 Tbr1 - T-box brain protein 1 - Mus musculus (Mouse) - Tbr1 gene Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:9883721, PubMed:11239428, PubMed:21285371). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (PubMed:21285371). Indicus|evm.model.CM009520.1.770 Q920G9 GMCL1_MOUSE 56.308 0.984802 0.627863 Gmcl1 - Germ cell-less protein-like 1 - Mus musculus (Mouse) - Gmcl1 gene Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport. Indicus|evm.model.CM009520.1.771 Q8IUQ4 SIAH1_HUMAN 76.761 0.992982 1.01064 SIAH1 - E3 ubiquitin-protein ligase SIAH1 - Homo sapiens (Human) - SIAH1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:10747903, PubMed:11146551, PubMed:11389839, PubMed:11389840, PubMed:11483517, PubMed:11483518, PubMed:11752454, PubMed:12072443). Confers constitutive instability to HIPK2 through proteasomal degradation (PubMed:18536714). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Has some overlapping function with SIAH2 (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (By similarity). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Indicus|evm.model.CM009520.1.773 Q9NS84 CHST7_HUMAN 92.181 0.995893 1.00206 CHST7 - Carbohydrate sulfotransferase 7 - Homo sapiens (Human) - CHST7 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc. Indicus|evm.model.CM009520.1.774 Q96T83 SL9A7_HUMAN 95.397 0.982812 0.882759 SLC9A7 - Sodium/hydrogen exchanger 7 - Homo sapiens (Human) - SLC9A7 gene Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to the regulation of Golgi apparatus volume and pH. Indicus|evm.model.CM009520.1.775 Q08945 SSRP1_HUMAN 71.848 0.984456 0.816643 SSRP1 - FACT complex subunit SSRP1 - Homo sapiens (Human) - SSRP1 gene Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. Indicus|evm.model.CM009520.1.776 Q58DW5 RL5_BOVIN 73.490 0.992126 0.855219 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Indicus|evm.model.CM009520.1.777 O75695 XRP2_HUMAN 92.857 0.994302 1.00286 RP2 - Protein XRP2 - Homo sapiens (Human) - RP2 gene Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. Indicus|evm.model.CM009520.1.779 Q9TTJ5 RGN_BOVIN 99.331 0.272644 3.65552 RGN - Regucalcin - Bos taurus (Bovine) - RGN gene Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). Indicus|evm.model.CM009520.1.780 Q8HXG5 NDUBB_BOVIN 100.000 0.987097 1.00649 NDUFB11 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor - Bos taurus (Bovine) - NDUFB11 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009520.1.781 P70501 RBM10_RAT 97.015 0.0661986 1.17019 Rbm10 - RNA-binding protein 10 - Rattus norvegicus (Rat) - Rbm10 gene Not known. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (PubMed:8760884). May bind to specific miRNA hairpins (By similarity). Indicus|evm.model.CM009520.1.782 A3KMV5 UBA1_BOVIN 98.384 0.607247 1.6172 UBA1 - Ubiquitin-like modifier-activating enzyme 1 - Bos taurus (Bovine) - UBA1 gene Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. Indicus|evm.model.CM009520.1.783 Q01988 UBP11_CANLF 89.462 0.447686 2.23371 USP11 - Ubiquitin carboxyl-terminal hydrolase 11 - Canis lupus familiaris (Dog) - USP11 gene Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex. Indicus|evm.model.CM009520.1.784 Q2NL01 GPX8_BOVIN 47.500 0.375 0.497608 GPX8 - Probable glutathione peroxidase 8 - Bos taurus (Bovine) - GPX8 gene peroxidase activity Indicus|evm.model.CM009520.1.785 P51786 ZN157_HUMAN 85.885 0.964455 0.833992 ZNF157 - Zinc finger protein 157 - Homo sapiens (Human) - ZNF157 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.786 P51814 ZNF41_HUMAN 79.218 0.996134 0.945189 ZNF41 - Zinc finger protein 41 - Homo sapiens (Human) - ZNF41 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.787 O19004 ARAF_PIG 92.824 0.996885 1.05941 ARAF - Serine/threonine-protein kinase A-Raf - Sus scrofa (Pig) - ARAF gene Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). Indicus|evm.model.CM009520.1.788 O62732 SYN1_CANLF 95.858 0.622222 0.650602 SYN1 - Synapsin-1 - Canis lupus familiaris (Dog) - SYN1 gene Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). Indicus|evm.model.CM009520.1.789 P20414 TIMP1_BOVIN 99.034 0.872881 1.1401 TIMP1 - Metalloproteinase inhibitor 1 precursor - Bos taurus (Bovine) - TIMP1 gene Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Indicus|evm.model.CM009520.1.790 P51508 ZNF81_HUMAN 83.826 0.972887 0.948563 ZNF81 - Zinc finger protein 81 - Homo sapiens (Human) - ZNF81 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.791 P17599 SYN1_BOVIN 99.248 0.631579 0.296034 SYN1 - Synapsin-1 - Bos taurus (Bovine) - SYN1 gene Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). Indicus|evm.model.CM009520.1.792 Q9BSK4 FEM1A_HUMAN 60.927 0.545113 0.397608 FEM1A - Protein fem-1 homolog A - Homo sapiens (Human) - FEM1A gene Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4. Indicus|evm.model.CM009520.1.793 Q5EA28 CXXC1_BOVIN 47.500 0.418519 0.410334 CXXC1 - CXXC-type zinc finger protein 1 - Bos taurus (Bovine) - CXXC1 gene Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. Indicus|evm.model.CM009520.1.794 P17599 SYN1_BOVIN 100.000 0.984252 0.179887 SYN1 - Synapsin-1 - Bos taurus (Bovine) - SYN1 gene Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). Indicus|evm.model.CM009520.1.795 P27918 PROP_HUMAN 74.887 0.948387 0.991471 CFP - Properdin precursor - Homo sapiens (Human) - CFP gene A positive regulator of the alternate pathway (AP) of complement (PubMed:20382442, PubMed:28264884). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed:20382442, PubMed:28264884). Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed:31507604). Indicus|evm.model.CM009520.1.796 P19419 ELK1_HUMAN 87.955 0.995465 1.03037 ELK1 - ETS domain-containing protein Elk-1 - Homo sapiens (Human) - ELK1 gene Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity). Indicus|evm.model.CM009520.1.797 Q32P97 UXT_BOVIN 99.359 0.545775 1.82051 UXT - Protein UXT - Bos taurus (Bovine) - UXT gene Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Indicus|evm.model.CM009520.1.798 P39947 CCNC_RAT 91.818 0.981982 0.399281 Ccnc - Cyclin-C - Rattus norvegicus (Rat) - Ccnc gene Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity). Indicus|evm.model.CM009520.1.799 P35507 KC1B_BOVIN 89.706 0.87013 0.229167 CSNK1B - Casein kinase I isoform beta - Bos taurus (Bovine) - CSNK1B gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Indicus|evm.model.CM009520.1.800 P35507 KC1B_BOVIN 100.000 0.994065 1.00298 CSNK1B - Casein kinase I isoform beta - Bos taurus (Bovine) - CSNK1B gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Indicus|evm.model.CM009520.1.801 P51508 ZNF81_HUMAN 73.611 0.577236 0.186082 ZNF81 - Zinc finger protein 81 - Homo sapiens (Human) - ZNF81 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.802 Q9Y473 ZN175_HUMAN 72.727 0.385542 0.116737 ZNF175 - Zinc finger protein 175 - Homo sapiens (Human) - ZNF175 gene Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity. Indicus|evm.model.CM009520.1.804 Q16384 SSX1_HUMAN 45.304 0.716 1.32979 SSX1 - Protein SSX1 - Homo sapiens (Human) - SSX1 gene Could act as a modulator of transcription. Indicus|evm.model.CM009520.1.805 Q1RML4 SPIC_BOVIN 96.396 0.982143 0.451613 SPIC - Transcription factor Spi-C - Bos taurus (Bovine) - SPIC gene Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). Indicus|evm.model.CM009520.1.806 Q5E9S9 S38A5_BOVIN 99.788 0.995763 0.987448 SLC38A5 - Sodium-coupled neutral amino acid transporter 5 - Bos taurus (Bovine) - SLC38A5 gene Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium (By similarity). Indicus|evm.model.CM009520.1.807 Q9UET6 TRM7_HUMAN 91.159 0.990909 1.00304 FTSJ1 - Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase - Homo sapiens (Human) - FTSJ1 gene Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. Indicus|evm.model.CM009520.1.808 Q9H237 PORCN_HUMAN 95.879 0.995565 0.978308 PORCN - Protein-serine O-palmitoleoyltransferase porcupine - Homo sapiens (Human) - PORCN gene Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors. Indicus|evm.model.CM009520.1.809 Q15125 EBP_HUMAN 85.388 0.943723 1.00435 EBP - 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase - Homo sapiens (Human) - EBP gene Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. Indicus|evm.model.CM009520.1.810 A1A5B6 TBC25_MOUSE 91.821 0.940407 0.927224 Tbc1d25 - TBC1 domain family member 25 - Mus musculus (Mouse) - Tbc1d25 gene Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. Indicus|evm.model.CM009520.1.811 W8E7I1 RBM3_CAPHI 99.375 0.987578 1.00625 RBM3 - RNA-binding protein 3 - Capra hircus (Goat) - RBM3 gene Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation. Indicus|evm.model.CM009520.1.812 Q5RF24 WDR13_PONAB 100.000 0.995885 1.00206 WDR13 - WD repeat-containing protein 13 - Pongo abelii (Sumatran orangutan) - WDR13 gene Indicus|evm.model.CM009520.1.813 Q32PB0 SSBP_BOVIN 98.333 0.991667 0.810811 SSBP1 - Single-stranded DNA-binding protein, mitochondrial precursor - Bos taurus (Bovine) - SSBP1 gene Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair. Indicus|evm.model.CM009520.1.814 P42768 WASP_HUMAN 71.053 0.413534 0.26494 WAS - Wiskott-Aldrich syndrome protein - Homo sapiens (Human) - WAS gene Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Indicus|evm.model.CM009520.1.815 P42768 WASP_HUMAN 89.773 0.769912 0.2251 WAS - Wiskott-Aldrich syndrome protein - Homo sapiens (Human) - WAS gene Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Indicus|evm.model.CM009520.1.816 Q2NL30 SUV91_BOVIN 99.757 0.995157 1.00243 SUV39H1 - Histone-lysine N-methyltransferase SUV39H1 - Bos taurus (Bovine) - SUV39H1 gene Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity). Indicus|evm.model.CM009520.1.817 P15976 GATA1_HUMAN 91.389 0.591736 1.46489 GATA1 - Erythroid transcription factor - Homo sapiens (Human) - GATA1 gene Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). Indicus|evm.model.CM009520.1.818 Q9UBN7 HDAC6_HUMAN 74.178 0.922951 1.00412 HDAC6 - Histone deacetylase 6 - Homo sapiens (Human) - HDAC6 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10220385). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10220385). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10220385). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Indicus|evm.model.CM009520.1.819 Q7Z444 RASE_HUMAN 77.350 0.6793 1.4721 ERAS - GTPase ERas precursor - Homo sapiens (Human) - ERAS gene Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity). Indicus|evm.model.CM009520.1.820 Q9UHG2 PCS1N_HUMAN 79.923 0.992308 1 PCSK1N - ProSAAS precursor - Homo sapiens (Human) - PCSK1N gene May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity). Indicus|evm.model.CM009520.1.821 Q2HJE9 TI17B_BOVIN 77.528 0.987261 0.912791 TIMM17B - Mitochondrial import inner membrane translocase subunit Tim17-B - Bos taurus (Bovine) - TIMM17B gene Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Indicus|evm.model.CM009520.1.822 Q2HJC9 PQBP1_BOVIN 100.000 0.992424 1.0038 PQBP1 - Polyglutamine-binding protein 1 - Bos taurus (Bovine) - PQBP1 gene Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production. Indicus|evm.model.CM009520.1.823 Q58DA6 S35A2_BOVIN 99.491 0.994924 1.00254 SLC35A2 - UDP-galactose translocator - Bos taurus (Bovine) - SLC35A2 gene Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. Indicus|evm.model.CM009520.1.824 Q2YDU3 OTUD5_RAT 99.728 0.589372 1.09717 Otud5 - OTU domain-containing protein 5 - Rattus norvegicus (Rat) - Otud5 gene Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity). Indicus|evm.model.CM009520.1.825 Q52PG9 KCND1_BOVIN 99.846 0.996918 1.00154 KCND1 - Potassium voltage-gated channel subfamily D member 1 - Bos taurus (Bovine) - KCND1 gene Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (By similarity). Indicus|evm.model.CM009520.1.826 Q4V328 GRAP1_HUMAN 94.768 0.997625 1.00119 GRIPAP1 - GRIP1-associated protein 1 - Homo sapiens (Human) - GRIPAP1 gene Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). Indicus|evm.model.CM009520.1.827 Q05B92 TFE3_BOVIN 100.000 0.996516 1.00175 TFE3 - Transcription factor E3 - Bos taurus (Bovine) - TFE3 gene Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (By similarity). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation. Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue. Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (By similarity). Indicus|evm.model.CM009520.1.828 Q96HB5 CC120_HUMAN 83.886 0.95122 1.10635 CCDC120 - Coiled-coil domain-containing protein 120 - Homo sapiens (Human) - CCDC120 gene Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. Indicus|evm.model.CM009520.1.829 Q2KHX3 PRAF2_BOVIN 100.000 0.988827 1.00562 PRAF2 - PRA1 family protein 2 - Bos taurus (Bovine) - PRAF2 gene May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity). Indicus|evm.model.CM009520.1.830 Q9Y484 WIPI4_HUMAN 99.167 0.99446 1.00278 WDR45 - WD repeat domain phosphoinositide-interacting protein 4 - Homo sapiens (Human) - WDR45 gene Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066). Indicus|evm.model.CM009520.1.831 P39032 RL36_RAT 81.609 0.86 0.952381 Rpl36 - 60S ribosomal protein L36 - Rattus norvegicus (Rat) - Rpl36 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009520.1.832 Q92917 GPKOW_HUMAN 79.752 0.995825 1.0063 GPKOW - G-patch domain and KOW motifs-containing protein - Homo sapiens (Human) - GPKOW gene RNA-binding protein involved in pre-mRNA splicing. Indicus|evm.model.CM009520.1.834 Q9H6Y5 MAGIX_HUMAN 67.407 0.992593 0.808383 MAGIX - PDZ domain-containing protein MAGIX - Homo sapiens (Human) - MAGIX gene Indicus|evm.model.CM009520.1.835 Q6Y1E2 PLP2_BOVIN 100.000 0.986928 1.00658 PLP2 - Proteolipid protein 2 - Bos taurus (Bovine) - PLP2 gene May play a role in cell differentiation in the intestinal epithelium. Indicus|evm.model.CM009520.1.836 Q80VL3 PRIC3_MOUSE 91.387 0.764895 0.995192 Prickle3 - Prickle planar cell polarity protein 3 - Mus musculus (Mouse) - Prickle3 gene Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). Indicus|evm.model.CM009520.1.837 P20488 SYPH_BOVIN 99.361 0.993631 1.00319 SYP - Synaptophysin - Bos taurus (Bovine) - SYP gene Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). Indicus|evm.model.CM009520.1.838 O60840 CAC1F_HUMAN 89.659 0.997047 0.856348 CACNA1F - Voltage-dependent L-type calcium channel subunit alpha-1F - Homo sapiens (Human) - CACNA1F gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization. Indicus|evm.model.CM009520.1.839 Q1RMI8 CCD22_BOVIN 94.896 0.996815 1.05546 CCDC22 - Coiled-coil domain-containing protein 22 - Bos taurus (Bovine) - CCDC22 gene Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Indicus|evm.model.CM009520.1.840 Q6U8D7 FOXP3_MACFA 90.255 0.928726 1.07425 FOXP3 - Forkhead box protein P3 - Macaca fascicularis (Crab-eating macaque) - FOXP3 gene Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7. Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1. Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development. Inhibits the transcriptional activator activity of RORA. Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4. Indicus|evm.model.CM009520.1.841 Q6ZSY5 PPR3F_HUMAN 83.047 0.996287 1.01126 PPP1R3F - Protein phosphatase 1 regulatory subunit 3F - Homo sapiens (Human) - PPP1R3F gene Glycogen-targeting subunit for protein phosphatase 1 (PP1). Indicus|evm.model.CM009520.1.842 Q5JUK9 PAGE3_HUMAN 56.757 0.688679 0.938053 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Indicus|evm.model.CM009520.1.843 A6NNY8 UBP27_HUMAN 98.174 0.995444 1.00228 USP27X - Ubiquitin carboxyl-terminal hydrolase 27 - Homo sapiens (Human) - USP27X gene Deubiquitinase that can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal. By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity. Indicus|evm.model.CM009520.1.844 Q10569 CPSF1_BOVIN 62.319 0.363636 0.129501 CPSF1 - Cleavage and polyadenylation specificity factor subunit 1 - Bos taurus (Bovine) - CPSF1 gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). Indicus|evm.model.CM009520.1.845 Q2M218 ZN630_HUMAN 71.809 0.894231 0.633181 ZNF630 - Zinc finger protein 630 - Homo sapiens (Human) - ZNF630 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.846 Q32PD6 LYZL5_BOVIN 100.000 0.987261 1.00641 SPACA5 - Sperm acrosome-associated protein 5 precursor - Bos taurus (Bovine) - SPACA5 gene Indicus|evm.model.CM009520.1.847 P17025 ZN182_HUMAN 92.730 0.9872 0.978091 ZNF182 - Zinc finger protein 182 - Homo sapiens (Human) - ZNF182 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.848 Q9GKE7 CLCN5_PIG 97.404 0.997531 0.992647 CLCN5 - H(+)/Cl(-) exchange transporter 5 - Sus scrofa (Pig) - CLCN5 gene Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). Indicus|evm.model.CM009520.1.849 Q8K1Q0 NMT1_RAT 53.234 0.689516 0.5 Nmt1 - Glycylpeptide N-tetradecanoyltransferase 1 - Rattus norvegicus (Rat) - Nmt1 gene Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Indicus|evm.model.CM009520.1.850 Q60662 AKAP4_MOUSE 81.301 0.993031 1.01413 Akap4 - A-kinase anchor protein 4 precursor - Mus musculus (Mouse) - Akap4 gene Major structural component of sperm fibrous sheath. Plays a role in sperm motility (PubMed:12167408). Indicus|evm.model.CM009520.1.851 P39963 CCNB3_CHICK 63.971 0.204893 3.24566 CCNB3 - G2/mitotic-specific cyclin-B3 - Gallus gallus (Chicken) - CCNB3 gene Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Could be involved at the G2/M (mitosis or meiosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Indicus|evm.model.CM009520.1.852 Q5KSL6 DGKK_HUMAN 84.949 0.882353 0.695515 DGKK - Diacylglycerol kinase kappa - Homo sapiens (Human) - DGKK gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Indicus|evm.model.CM009520.1.854 Q64478 H2B1H_MOUSE 91.270 0.984252 1.00794 H2bc9 - Histone H2B type 1-H - Mus musculus (Mouse) - H2bc9 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009520.1.855 P39942 VATD_BOVIN 92.188 0.989637 0.781377 ATP6V1D - V-type proton ATPase subunit D - Bos taurus (Bovine) - ATP6V1D gene Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). Indicus|evm.model.CM009520.1.859 Q6PX77 BMP15_BOVIN 98.814 0.923077 0.692893 BMP15 - Bone morphogenetic protein 15 precursor - Bos taurus (Bovine) - BMP15 gene May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). Indicus|evm.model.CM009520.1.862 Q58CW0 NUD11_BOVIN 99.390 0.987879 1.0061 NUDT11 - Diphosphoinositol polyphosphate phosphohydrolase 3-beta - Bos taurus (Bovine) - NUDT11 gene Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Indicus|evm.model.CM009520.1.863 Q9P203 BTBD7_HUMAN 80.583 0.980392 0.090106 BTBD7 - BTB/POZ domain-containing protein 7 - Homo sapiens (Human) - BTBD7 gene Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). Indicus|evm.model.CM009520.1.864 P15170 ERF3A_HUMAN 93.587 0.78481 1.26653 GSPT1 - Eukaryotic peptide chain release factor GTP-binding subunit ERF3A - Homo sapiens (Human) - GSPT1 gene Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). Indicus|evm.model.CM009520.1.865 Q562A2 ZFR_RAT 90.678 0.790541 0.137931 Zfr - Zinc finger RNA-binding protein - Rattus norvegicus (Rat) - Zfr gene Involved in postimplantation and gastrulation stages of development (By similarity). Binds to DNA and RNA (By similarity). Involved in the nucleocytoplasmic shuttling of STAU2. Indicus|evm.model.CM009520.1.866 O88532 ZFR_MOUSE 95.960 0.98995 0.185289 Zfr - Zinc finger RNA-binding protein - Mus musculus (Mouse) - Zfr gene Involved in postimplantation and gastrulation stages of development. Binds to DNA and RNA. Involved in the nucleocytoplasmic shuttling of STAU2 (By similarity). Indicus|evm.model.CM009520.1.867 Q5R8F7 PABP1_PONAB 94.488 0.992157 0.400943 PABPC1 - Polyadenylate-binding protein 1 - Pongo abelii (Sumatran orangutan) - PABPC1 gene Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability. Indicus|evm.model.CM009520.1.868 Q5JUK9 PAGE3_HUMAN 47.312 0.779661 1.04425 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Indicus|evm.model.CM009520.1.869 Q5JUK9 PAGE3_HUMAN 52.222 0.463542 1.69912 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Indicus|evm.model.CM009520.1.871 Q5JUK9 PAGE3_HUMAN 47.917 0.766129 1.09735 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Indicus|evm.model.CM009520.1.872 Q5JUK9 PAGE3_HUMAN 50.526 0.746032 1.11504 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Indicus|evm.model.CM009520.1.873 P62856 RS26_RAT 96.522 0.982759 1.0087 Rps26 - 40S ribosomal protein S26 - Rattus norvegicus (Rat) - Rps26 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, mRNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.CM009520.1.875 A6QLI5 MAGD4_BOVIN 94.189 0.99431 0.95 MAGED4 - Melanoma-associated antigen D4 - Bos taurus (Bovine) - MAGED4 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). Indicus|evm.model.CM009520.1.876 Q6ITT4 MAGD1_PIG 91.468 0.931116 1.07398 MAGED1 - Melanoma-associated antigen D1 - Sus scrofa (Pig) - MAGED1 gene Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed (By similarity). Indicus|evm.model.CM009520.1.877 Q5E9H8 GP173_BOVIN 100.000 0.994652 1.00268 GPR173 - Probable G-protein coupled receptor 173 - Bos taurus (Bovine) - GPR173 gene Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (By similarity). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (By similarity). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (By similarity). Indicus|evm.model.CM009520.1.878 Q9BE64 TSYL2_MACFA 69.655 0.997179 1.02014 TSPYL2 - Testis-specific Y-encoded-like protein 2 - Macaca fascicularis (Crab-eating macaque) - TSPYL2 gene Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression (By similarity). Indicus|evm.model.CM009520.1.879 Q2TGK3 ZDHC3_RAT 82.955 0.992337 0.87291 Zdhhc3 - Palmitoyltransferase ZDHHC3 - Rattus norvegicus (Rat) - Zdhhc3 gene Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (By similarity). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (By similarity). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (By similarity). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes (By similarity). Also constitutively palmitoylates DLG4 (PubMed:19596852). May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2. Indicus|evm.model.CM009520.1.880 Q38JA7 KDM5C_CANLF 94.744 0.998717 1.00193 KDM5C - Lysine-specific demethylase 5C - Canis lupus familiaris (Dog) - KDM5C gene Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Indicus|evm.model.CM009520.1.881 Q5JU85 IQEC2_HUMAN 97.243 0.728118 0.867608 IQSEC2 - IQ motif and SEC7 domain-containing protein 2 - Homo sapiens (Human) - IQSEC2 gene Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins. Indicus|evm.model.CM009520.1.883 O97593 SMC1A_BOVIN 99.513 0.998371 0.995945 SMC1A - Structural maintenance of chromosomes protein 1A - Bos taurus (Bovine) - SMC1A gene Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. Indicus|evm.model.CM009520.1.884 Q0VC09 RIBC1_BOVIN 99.736 0.986945 1.01055 RIBC1 - RIB43A-like with coiled-coils protein 1 - Bos taurus (Bovine) - RIBC1 gene Indicus|evm.model.CM009520.1.885 O02691 HCD2_BOVIN 100.000 0.992366 1.00383 HSD17B10 - 3-hydroxyacyl-CoA dehydrogenase type-2 - Bos taurus (Bovine) - HSD17B10 gene Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism. Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA. Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway. Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids. Oxidizes allopregnanolone/brexanolone at the 3alpha-hydroxyl group, which is known to be critical for the activation of gamma-aminobutyric acid receptors (GABAARs) chloride channel. Has phospholipase C-like activity toward cardiolipin and its oxidized species. Likely oxidizes the 2'-hydroxyl in the head group of cardiolipin to form a ketone intermediate that undergoes nucleophilic attack by water and fragments into diacylglycerol, dihydroxyacetone and orthophosphate. Has higher affinity for cardiolipin with oxidized fatty acids and may degrade these species during the oxidative stress response to protect cells from apoptosis. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structural and functional integrity of mitochondria. Indicus|evm.model.CM009520.1.886 P51593 HUWE1_RAT 100.000 0.0726738 13.7174 Huwe1 - E3 ubiquitin-protein ligase HUWE1 - Rattus norvegicus (Rat) - Huwe1 gene E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (By similarity). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (By similarity). Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (By similarity). Mediates polyubiquitination of PA2G4 (By similarity). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (By similarity). Indicus|evm.model.CM009520.1.887 O15347 HMGB3_HUMAN 81.548 0.800995 1.005 HMGB3 - High mobility group protein B3 - Homo sapiens (Human) - HMGB3 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). Indicus|evm.model.CM009520.1.888 Q9UPP1 PHF8_HUMAN 95.347 0.998102 0.99434 PHF8 - Histone lysine demethylase PHF8 - Homo sapiens (Human) - PHF8 gene Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Indicus|evm.model.CM009520.1.889 P02561 TPM4_HORSE 83.333 0.935484 0.5 TPM4 - Tropomyosin alpha-4 chain - Equus caballus (Horse) - TPM4 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. Indicus|evm.model.CM009520.1.890 Q9NX05 F120C_HUMAN 93.163 0.964126 0.813869 FAM120C - Constitutive coactivator of PPAR-gamma-like protein 2 - Homo sapiens (Human) - FAM120C gene nucleus, RNA binding Indicus|evm.model.CM009520.1.891 Q9NX05 F120C_HUMAN 88.660 0.659722 0.131387 FAM120C - Constitutive coactivator of PPAR-gamma-like protein 2 - Homo sapiens (Human) - FAM120C gene nucleus, RNA binding Indicus|evm.model.CM009520.1.892 P83741 WNK1_MOUSE 83.967 0.210436 0.733698 Wnk1 - Serine/threonine-protein kinase WNK1 - Mus musculus (Mouse) - Wnk1 gene Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (PubMed:21317537, PubMed:23542070). Indicus|evm.model.CM009520.1.893 Q3T090 TSR2_BOVIN 100.000 0.984375 1.01053 TSR2 - Pre-rRNA-processing protein TSR2 homolog - Bos taurus (Bovine) - TSR2 gene May be involved in 20S pre-rRNA processing. Indicus|evm.model.CM009520.1.894 P98174 FGD1_HUMAN 95.317 0.997919 1 FGD1 - FYVE, RhoGEF and PH domain-containing protein 1 - Homo sapiens (Human) - FGD1 gene Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Indicus|evm.model.CM009520.1.895 Q17R06 RAB21_BOVIN 94.762 0.93722 1.0045 RAB21 - Ras-related protein Rab-21 precursor - Bos taurus (Bovine) - RAB21 gene Small GTPase involved in membrane trafficking control (By similarity). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity). Indicus|evm.model.CM009520.1.896 Q3T0J9 GNL3L_BOVIN 100.000 0.996528 1.00174 GNL3L - Guanine nucleotide-binding protein-like 3-like protein - Bos taurus (Bovine) - GNL3L gene Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity). Indicus|evm.model.CM009520.1.897 Q12816 TROP_HUMAN 66.388 0.841463 0.343816 TRO - Trophinin - Homo sapiens (Human) - TRO gene Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion. Indicus|evm.model.CM009520.1.898 P49872 F261_BOVIN 99.575 0.828924 1.20382 PFKFB1 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 - Bos taurus (Bovine) - PFKFB1 gene Synthesis and degradation of fructose 2,6-bisphosphate. Indicus|evm.model.CM009520.1.899 Q5E9N9 APEX2_BOVIN 99.611 0.996117 1.00195 APEX2 - DNA-(apurinic or apyrimidinic site) endonuclease 2 - Bos taurus (Bovine) - APEX2 gene Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). Indicus|evm.model.CM009520.1.900 Q3ZC31 HEM0_BOVIN 100.000 0.996599 1.0017 ALAS2 - 5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor - Bos taurus (Bovine) - ALAS2 gene mitochondrial inner membrane, mitochondrion, 5-aminolevulinate synthase activity, erythrocyte development, heme biosynthetic process, hemoglobin biosynthetic process, response to hypoxia Indicus|evm.model.CM009520.1.902 Q9H213 MAGH1_HUMAN 93.878 0.886364 1.00457 MAGEH1 - Melanoma-associated antigen H1 - Homo sapiens (Human) - MAGEH1 gene apoptotic process Indicus|evm.model.CM009520.1.903 Q6PJQ5 FOXR2_HUMAN 68.987 0.993691 1.01929 FOXR2 - Forkhead box protein R2 - Homo sapiens (Human) - FOXR2 gene chromatin, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific double-stranded DNA binding Indicus|evm.model.CM009520.1.904 Q63486 RRAGA_RAT 98.083 0.899135 1.10863 Rraga - Ras-related GTP-binding protein A - Rattus norvegicus (Rat) - Rraga gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Indicus|evm.model.CM009520.1.905 O95600 KLF8_HUMAN 85.490 0.902878 0.774373 KLF8 - Krueppel-like factor 8 - Homo sapiens (Human) - KLF8 gene Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). Indicus|evm.model.CM009520.1.906 O95600 KLF8_HUMAN 96.774 0.67033 0.253482 KLF8 - Krueppel-like factor 8 - Homo sapiens (Human) - KLF8 gene Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). Indicus|evm.model.CM009520.1.907 Q4R6E8 LAP4B_MACFA 73.034 0.967033 0.402655 LAPTM4B - Lysosomal-associated transmembrane protein 4B - Macaca fascicularis (Crab-eating macaque) - LAPTM4B gene Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. Indicus|evm.model.CM009520.1.908 Q9UHD9 UBQL2_HUMAN 96.474 0.9968 1.0016 UBQLN2 - Ubiquilin-2 - Homo sapiens (Human) - UBQLN2 gene Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683). Indicus|evm.model.CM009520.1.909 Q9Y6I9 TX264_HUMAN 66.667 0.978723 0.300319 TEX264 - Testis-expressed protein 264 - Homo sapiens (Human) - TEX264 gene Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270). Indicus|evm.model.CM009520.1.910 P61078 UB2D3_RAT 65.657 0.915663 0.564626 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Indicus|evm.model.CM009520.1.911 Q5RA80 SPIN2_PONAB 57.692 0.49359 0.604651 SPIN2 - Spindlin-2 - Pongo abelii (Sumatran orangutan) - SPIN2 gene May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity. Indicus|evm.model.CM009520.1.912 Q2KI39 SPIN2_BOVIN 100.000 0.992278 1.00388 SPIN2 - Spindlin-2 - Bos taurus (Bovine) - SPIN2 gene May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity. Indicus|evm.model.CM009520.1.914 Q5RA80 SPIN2_PONAB 94.961 0.992278 1.00388 SPIN2 - Spindlin-2 - Pongo abelii (Sumatran orangutan) - SPIN2 gene May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity. Indicus|evm.model.CM009520.1.915 Q5RA80 SPIN2_PONAB 84.884 0.992278 1.00388 SPIN2 - Spindlin-2 - Pongo abelii (Sumatran orangutan) - SPIN2 gene May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity. Indicus|evm.model.CM009520.1.916 P67809 YBOX1_HUMAN 66.292 0.271605 1 YBX1 - Y-box-binding protein 1 - Homo sapiens (Human) - YBX1 gene DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:8188694, PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:8188694, PubMed:18809583). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). Indicus|evm.model.CM009520.1.917 P21573 YBOX1_XENLA 59.551 0.335878 0.864686 ybx1 - Y-box-binding protein 1 - Xenopus laevis (African clawed frog) - ybx1 gene DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation (By similarity). Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and preventing mRNA decay (By similarity). Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation (By similarity). Also promotes maternal-to-zygotic transition in oocytes and embryos by promoting translation repression; molecular mechanisms governing translation repression are unknown (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (By similarity). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (By similarity). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (By similarity). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (By similarity). Also able to bind DNA and regulate transcription (PubMed:2247479). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3') (PubMed:2247479). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (By similarity). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (By similarity). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity). Indicus|evm.model.CM009520.1.918 Q9BQS7 HEPH_HUMAN 89.551 0.978849 1.02073 HEPH - Hephaestin precursor - Homo sapiens (Human) - HEPH gene May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1. Indicus|evm.model.CM009520.1.919 Q9Y279 VSIG4_HUMAN 89.431 0.36747 0.83208 VSIG4 - V-set and immunoglobulin domain-containing protein 4 precursor - Homo sapiens (Human) - VSIG4 gene Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. Indicus|evm.model.CM009520.1.920 Q2HJ49 MOES_BOVIN 100.000 0.99654 1.00173 MSN - Moesin - Bos taurus (Bovine) - MSN gene Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (By similarity). Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation (By similarity). Indicus|evm.model.CM009520.1.921 Q9Y4W2 LAS1L_HUMAN 75.968 0.939119 1.05177 LAS1L - Ribosomal biogenesis protein LAS1L - Homo sapiens (Human) - LAS1L gene Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Indicus|evm.model.CM009520.1.922 Q5HYM0 ZC12B_HUMAN 92.455 0.996416 1.0012 ZC3H12B - Probable ribonuclease ZC3H12B - Homo sapiens (Human) - ZC3H12B gene May function as RNase and regulate the levels of target RNA species. Indicus|evm.model.CM009520.1.923 Q9BYE7 PCGF6_HUMAN 71.233 0.821839 0.497143 PCGF6 - Polycomb group RING finger protein 6 - Homo sapiens (Human) - PCGF6 gene Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Indicus|evm.model.CM009520.1.924 Q6GM06 OTU6B_XENLA 56.522 0.463918 0.329932 otud6b - Deubiquitinase OTUD6B - Xenopus laevis (African clawed frog) - otud6b gene Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes. Indicus|evm.model.CM009520.1.925 Q68FG0 ZC4H2_MOUSE 99.502 0.990099 0.901786 Zc4h2 - Zinc finger C4H2 domain-containing protein - Mus musculus (Mouse) - Zc4h2 gene Plays a role in interneurons differentiation. Involved in neuronal development and in neuromuscular junction formation. Indicus|evm.model.CM009520.1.927 Q96EF0 MTMR8_HUMAN 94.737 0.99596 0.703125 MTMR8 - Myotubularin-related protein 8 - Homo sapiens (Human) - MTMR8 gene Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:22647598, PubMed:26143924). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:22647598, PubMed:26143924). In complex with MTMR9, negatively regulates autophagy (PubMed:22647598). Indicus|evm.model.CM009520.1.928 Q02372 NDUB8_BOVIN 95.918 0.737374 1.06452 NDUFB8 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor - Bos taurus (Bovine) - NDUFB8 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Indicus|evm.model.CM009520.1.929 Q8WXK4 ASB12_HUMAN 89.935 0.515152 1.92233 ASB12 - Ankyrin repeat and SOCS box protein 12 - Homo sapiens (Human) - ASB12 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009520.1.931 Q5JTC6 AMER1_HUMAN 82.586 0.998214 0.986784 AMER1 - APC membrane recruitment protein 1 - Homo sapiens (Human) - AMER1 gene Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. Indicus|evm.model.CM009520.1.932 Q58DL7 ARHG9_BOVIN 100.000 0.507246 1.96791 ARHGEF9 - Rho guanine nucleotide exchange factor 9 - Bos taurus (Bovine) - ARHGEF9 gene Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity). Indicus|evm.model.CM009520.1.934 Q56A73 SPIN4_HUMAN 98.795 0.992 1.00402 SPIN4 - Spindlin-4 - Homo sapiens (Human) - SPIN4 gene Exhibits H3K4me3-binding activity. Indicus|evm.model.CM009520.1.935 P21573 YBOX1_XENLA 68.539 0.237197 1.22442 ybx1 - Y-box-binding protein 1 - Xenopus laevis (African clawed frog) - ybx1 gene DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation (By similarity). Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and preventing mRNA decay (By similarity). Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation (By similarity). Also promotes maternal-to-zygotic transition in oocytes and embryos by promoting translation repression; molecular mechanisms governing translation repression are unknown (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (By similarity). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (By similarity). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (By similarity). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (By similarity). Also able to bind DNA and regulate transcription (PubMed:2247479). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3') (PubMed:2247479). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (By similarity). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (By similarity). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity). Indicus|evm.model.CM009520.1.936 P98169 ZXDB_HUMAN 90.200 0.894212 0.62391 ZXDB - Zinc finger X-linked protein ZXDB - Homo sapiens (Human) - ZXDB gene Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Indicus|evm.model.CM009520.1.937 P98169 ZXDB_HUMAN 84.540 0.997546 1.01494 ZXDB - Zinc finger X-linked protein ZXDB - Homo sapiens (Human) - ZXDB gene Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Indicus|evm.model.CM009520.1.939 Q9NY97 B3GN2_HUMAN 85.075 0.218391 1.53401 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Homo sapiens (Human) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. Indicus|evm.model.CM009520.1.940 O00571 DDX3X_HUMAN 89.194 0.908023 0.771903 DDX3X - ATP-dependent RNA helicase DDX3X - Homo sapiens (Human) - DDX3X gene Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:18628297, PubMed:17667941, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:31575075, PubMed:20127681, PubMed:21170385). Potentiate MAVS/DDX58-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:21170385, PubMed:27980081, PubMed:19913487). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). Indicus|evm.model.CM009520.1.941 O00571 DDX3X_HUMAN 91.000 0.980198 0.152568 DDX3X - ATP-dependent RNA helicase DDX3X - Homo sapiens (Human) - DDX3X gene Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:18628297, PubMed:17667941, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:31575075, PubMed:20127681, PubMed:21170385). Potentiate MAVS/DDX58-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:21170385, PubMed:27980081, PubMed:19913487). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). Indicus|evm.model.CM009520.1.942 Q5JUW0 KRBX4_HUMAN 75.676 0.304167 1.40351 KRBOX4 - KRAB domain-containing protein 4 - Homo sapiens (Human) - KRBOX4 gene Indicus|evm.model.CM009520.1.943 Q2M3X9 ZN674_HUMAN 79.346 0.99481 0.994836 ZNF674 - Zinc finger protein 674 - Homo sapiens (Human) - ZNF674 gene May be involved in transcriptional regulation. Indicus|evm.model.CM009520.1.944 P31622 GAG_JSRV 77.833 0.971154 0.339869 gag - Gag polyprotein - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - gag gene Matrix protein. Indicus|evm.model.CM009520.1.945 P31625 PRO_JSRV 57.700 0.988258 0.590069 pro - Gag-Pro polyprotein - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - pro gene Matrix protein. Indicus|evm.model.CM009520.1.946 P03360 POL_AVIRE 47.345 0.940678 0.204861 pol - Gag-Pol polyprotein - Avian reticuloendotheliosis virus - pol gene The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell. Indicus|evm.model.CM009520.1.947 Q58CX7 DIK2B_BOVIN 99.769 0.995392 1.00231 DIPK2B - Divergent protein kinase domain 2B precursor - Bos taurus (Bovine) - DIPK2B gene Indicus|evm.model.CM009520.1.948 O15550 KDM6A_HUMAN 98.485 0.984962 0.0949322 KDM6A - Lysine-specific demethylase 6A - Homo sapiens (Human) - KDM6A gene Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). Indicus|evm.model.CM009520.1.949 O15550 KDM6A_HUMAN 93.314 0.988327 0.733762 KDM6A - Lysine-specific demethylase 6A - Homo sapiens (Human) - KDM6A gene Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). Indicus|evm.model.CM009520.1.950 O15550 KDM6A_HUMAN 98.667 0.649123 0.0813704 KDM6A - Lysine-specific demethylase 6A - Homo sapiens (Human) - KDM6A gene Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). Indicus|evm.model.CM009520.1.951 Q5R8X2 DUS18_PONAB 76.344 0.939086 1.04787 DUSP18 - Dual specificity protein phosphatase 18 - Pongo abelii (Sumatran orangutan) - DUSP18 gene Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). Indicus|evm.model.CM009520.1.953 P36220 TBA_TORMA 63.736 0.954386 0.631929 Tubulin alpha chain - Torpedo marmorata (Marbled electric ray) Indicus|evm.model.CM009520.1.954 F1N5S9 FUND1_BOVIN 100.000 0.987179 1.00645 FUNDC1 - FUN14 domain-containing protein 1 - Bos taurus (Bovine) - FUNDC1 gene Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Indicus|evm.model.CM009520.1.955 O46415 FRIL_BOVIN 89.024 0.910112 0.508571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.956 Q93075 TATD2_HUMAN 55.115 0.9968 0.821288 TATDN2 - Putative deoxyribonuclease TATDN2 - Homo sapiens (Human) - TATDN2 gene Putative deoxyribonuclease. Indicus|evm.model.CM009520.1.957 Q5JST6 EFHC2_HUMAN 74.516 0.979502 0.911883 EFHC2 - EF-hand domain-containing family member C2 - Homo sapiens (Human) - EFHC2 gene axoneme, ciliary basal body, mitotic spindle, alpha-tubulin binding, cilium-dependent cell motility, mitotic cytokinesis, mitotic spindle organization, regulation of neuron projection development Indicus|evm.model.CM009520.1.958 Q2KI78 NDP_BOVIN 100.000 0.985075 1.00752 NDP - Norrin precursor - Bos taurus (Bovine) - NDP gene Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction (By similarity). Indicus|evm.model.CM009520.1.959 P56560 AOFB_BOVIN 99.808 0.996161 1.00192 MAOB - Amine oxidase [flavin-containing] B - Bos taurus (Bovine) - MAOB gene Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). Indicus|evm.model.CM009520.1.960 P21398 AOFA_BOVIN 99.810 0.556025 1.79507 MAOA - Amine oxidase [flavin-containing] A - Bos taurus (Bovine) - MAOA gene Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Indicus|evm.model.CM009520.1.961 Q4R615 IPP2C_MACFA 55.072 0.943925 1.0439 PPP1R2C - Protein phosphatase inhibitor 2 family member C - Macaca fascicularis (Crab-eating macaque) - PPP1R2C gene Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates (By similarity). Indicus|evm.model.CM009520.1.962 O14936 CSKP_HUMAN 96.760 0.997773 0.969762 CASK - Peripheral plasma membrane protein CASK - Homo sapiens (Human) - CASK gene Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). Indicus|evm.model.CM009520.1.963 Q9GZU5 NYX_HUMAN 87.591 0.288747 0.97921 NYX - Nyctalopin precursor - Homo sapiens (Human) - NYX gene extracellular matrix, extracellular space Indicus|evm.model.CM009520.1.964 Q3SZQ6 RL32_BOVIN 75.385 0.820513 0.577778 RPL32 - 60S ribosomal protein L32 - Bos taurus (Bovine) - RPL32 gene cytosolic large ribosomal subunit Indicus|evm.model.CM009520.1.965 O00571 DDX3X_HUMAN 98.943 0.996979 1 DDX3X - ATP-dependent RNA helicase DDX3X - Homo sapiens (Human) - DDX3X gene Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:18628297, PubMed:17667941, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:31575075, PubMed:20127681, PubMed:21170385). Potentiate MAVS/DDX58-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:21170385, PubMed:27980081, PubMed:19913487). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). Indicus|evm.model.CM009520.1.966 Q93008 USP9X_HUMAN 97.670 0.999224 1.00861 USP9X - Probable ubiquitin carboxyl-terminal hydrolase FAF-X - Homo sapiens (Human) - USP9X gene Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed:16322459, PubMed:18254724, PubMed:19135894, PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed:29626158). Indicus|evm.model.CM009520.1.968 P24049 RL17_RAT 93.023 0.97076 0.929348 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Indicus|evm.model.CM009520.1.969 O60244 MED14_HUMAN 97.868 0.998624 0.999312 MED14 - Mediator of RNA polymerase II transcription subunit 14 - Homo sapiens (Human) - MED14 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Indicus|evm.model.CM009520.1.970 Q8TB03 CX038_HUMAN 87.821 0.990385 0.978056 CXorf38 - Uncharacterized protein CXorf38 - Homo sapiens (Human) - CXorf38 gene Indicus|evm.model.CM009520.1.971 Q2M2T3 MPCX_BOVIN 99.448 0.989011 1.00552 Mitochondrial pyruvate carrier-like protein - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.972 P05386 RLA1_HUMAN 76.316 0.980392 0.894737 RPLP1 - 60S acidic ribosomal protein P1 - Homo sapiens (Human) - RPLP1 gene Plays an important role in the elongation step of protein synthesis. Indicus|evm.model.CM009520.1.973 P81134 RENR_BOVIN 100.000 0.946629 1.01425 ATP6AP2 - Renin receptor precursor - Bos taurus (Bovine) - ATP6AP2 gene Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (v-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Involved in many neuronal processes including synapse morphology and synaptic transmission (By similarity). Indicus|evm.model.CM009520.1.978 Q9NPA3 M1IP1_HUMAN 93.443 0.989071 1 MID1IP1 - Mid1-interacting protein 1 - Homo sapiens (Human) - MID1IP1 gene Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity). Indicus|evm.model.CM009520.1.979 P41732 TSN7_HUMAN 96.875 0.793594 1.12851 TSPAN7 - Tetraspanin-7 - Homo sapiens (Human) - TSPAN7 gene May be involved in cell proliferation and cell motility. Indicus|evm.model.CM009520.1.980 Q53VB8 FRIL_CANLF 55.866 0.988827 1.02286 FTL - Ferritin light chain - Canis lupus familiaris (Dog) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.982 Q9N1U7 OTC_BOVIN 85.311 0.993443 0.861582 OTC - Ornithine transcarbamylase, mitochondrial precursor - Bos taurus (Bovine) - OTC gene Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion. Indicus|evm.model.CM009520.1.983 Q9R0X5 RPGR_MOUSE 80.769 0.520408 0.0979021 Rpgr - X-linked retinitis pigmentosa GTPase regulator precursor - Mus musculus (Mouse) - Rpgr gene Could be a guanine-nucleotide releasing factor (By similarity). Plays a role in ciliogenesis (By similarity). Probably regulates cilia formation by regulating actin stress filaments and cell contractility (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia (By similarity). Plays an important role in photoreceptor integrity. Isoform 5 may play a critical role in spermatogenesis and in intraflagellar transport processes. Indicus|evm.model.CM009520.1.984 Q9N1T2 RPGR_CANLF 85.990 0.777358 0.264207 RPGR - X-linked retinitis pigmentosa GTPase regulator precursor - Canis lupus familiaris (Dog) - RPGR gene Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes. Indicus|evm.model.CM009520.1.985 Q9N1T2 RPGR_CANLF 69.822 0.512579 0.317049 RPGR - X-linked retinitis pigmentosa GTPase regulator precursor - Canis lupus familiaris (Dog) - RPGR gene Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes. Indicus|evm.model.CM009520.1.986 P78539 SRPX_HUMAN 82.284 0.976905 0.93319 SRPX - Sushi repeat-containing protein SRPX precursor - Homo sapiens (Human) - SRPX gene May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. Indicus|evm.model.CM009520.1.987 P19132 FRIH_RAT 55.801 0.978261 1.01099 Fth1 - Ferritin heavy chain - Rattus norvegicus (Rat) - Fth1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.988 Q9R0M3 SRPX_MOUSE 90.385 0.71831 0.153017 Srpx - Sushi-repeat-containing protein SRPX precursor - Mus musculus (Mouse) - Srpx gene autophagosome, endoplasmic reticulum, autophagy, negative regulation of cell proliferation involved in contact inhibition, phagolysosome assembly, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, response to endoplasmic reticulum stress Indicus|evm.model.CM009520.1.989 Q8TDW5 SYTL5_HUMAN 72.207 0.871688 0.982192 SYTL5 - Synaptotagmin-like protein 5 - Homo sapiens (Human) - SYTL5 gene May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. Indicus|evm.model.CM009520.1.990 Q9CQ70 H2AB1_MOUSE 61.798 0.745763 1.06306 H2ab1 - Histone H2A-Bbd type 1 - Mus musculus (Mouse) - H2ab1 gene Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells (PubMed:28366643). Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:19506029). Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes (PubMed:19506029). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). Indicus|evm.model.CM009520.1.991 Q6XXL8 DYLT3_SHEEP 99.138 0.982906 1.00862 DYNLT3 - Dynein light chain Tctex-type 3 - Ovis aries (Sheep) - DYNLT3 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity). Indicus|evm.model.CM009520.1.992 O46522 CY24B_BOVIN 99.825 0.996497 1.00175 CYBB - Cytochrome b-245 heavy chain - Bos taurus (Bovine) - CYBB gene Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. Indicus|evm.model.CM009520.1.993 Q49LS5 XK_PANTR 80.663 0.947507 0.858108 XK - Membrane transport protein XK - Pan troglodytes (Chimpanzee) - XK gene May be involved in sodium-dependent transport of neutral amino acids or oligopeptides. Indicus|evm.model.CM009520.1.994 Q6ZV70 LANC3_HUMAN 96.905 0.995249 1.00238 LANCL3 - LanC-like protein 3 - Homo sapiens (Human) - LANCL3 gene plasma membrane Indicus|evm.model.CM009520.1.996 Q5R8J7 FRIH_PONAB 60.000 0.972826 1.00546 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Indicus|evm.model.CM009520.1.997 Q5R8J7 FRIH_PONAB 48.913 0.98895 0.989071 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Indicus|evm.model.CM009520.1.998 P08267 FRIH_CHICK 52.299 0.905759 1.06111 FTH - Ferritin heavy chain - Gallus gallus (Chicken) - FTH gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.999 Q9BXU8 FHL17_HUMAN 58.580 0.843434 1.08197 FTHL17 - Ferritin heavy polypeptide-like 17 - Homo sapiens (Human) - FTHL17 gene cytoplasm, ferric iron binding, ferrous iron binding, ferroxidase activity, intracellular sequestering of iron ion Indicus|evm.model.CM009520.1.1000 Q5HY64 FA47C_HUMAN 51.163 0.379147 0.407729 FAM47C - Putative protein FAM47C - Homo sapiens (Human) - FAM47C gene Indicus|evm.model.CM009520.1.1001 A7Z070 TMG1_BOVIN 99.379 0.597015 1.22936 PRRG1 - Transmembrane gamma-carboxyglutamic acid protein 1 precursor - Bos taurus (Bovine) - PRRG1 gene Indicus|evm.model.CM009520.1.1002 Q5R8J7 FRIH_PONAB 54.396 0.983696 1.00546 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Indicus|evm.model.CM009520.1.1003 Q5R8J7 FRIH_PONAB 58.791 0.826484 1.19672 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Indicus|evm.model.CM009520.1.1004 Q5R8J7 FRIH_PONAB 52.459 0.64311 1.54645 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Indicus|evm.model.CM009520.1.1005 Q5R8J7 FRIH_PONAB 56.111 0.972826 1.00546 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Indicus|evm.model.CM009520.1.1006 P08267 FRIH_CHICK 56.180 0.44 1.11111 FTH - Ferritin heavy chain - Gallus gallus (Chicken) - FTH gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.1007 P15907 SIAT1_HUMAN 75.117 0.949239 0.485222 ST6GAL1 - Beta-galactoside alpha-2,6-sialyltransferase 1 - Homo sapiens (Human) - ST6GAL1 gene Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. Indicus|evm.model.CM009520.1.1008 Q9CQ70 H2AB1_MOUSE 58.511 0.715385 1.17117 H2ab1 - Histone H2A-Bbd type 1 - Mus musculus (Mouse) - H2ab1 gene Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells (PubMed:28366643). Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:19506029). Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes (PubMed:19506029). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). Indicus|evm.model.CM009520.1.1009 A2A368 MAGBG_HUMAN 67.421 0.711974 0.953704 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Indicus|evm.model.CM009520.1.1010 P26810 POL_MLVF5 46.575 0.685714 0.0603795 pol - Gag-Pol polyprotein - Friend murine leukemia virus (isolate 57) (FrMLV) - pol gene Plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag-Pol, or to Gag-Pol binding host factors. Interaction with HECT ubiquitin ligases probably links the viral protein to the host ESCRT pathway and facilitates release. Indicus|evm.model.CM009520.1.1011 Q6ZTR5 CFA47_HUMAN 61.881 0.991895 0.503295 CFAP47 - Cilia- and flagella-associated protein 47 - Homo sapiens (Human) - CFAP47 gene Indicus|evm.model.CM009520.1.1012 Q6ZTR5 CFA47_HUMAN 69.500 0.999165 0.375588 CFAP47 - Cilia- and flagella-associated protein 47 - Homo sapiens (Human) - CFAP47 gene Indicus|evm.model.CM009520.1.1013 A2A368 MAGBG_HUMAN 53.145 0.933131 1.01543 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Indicus|evm.model.CM009520.1.1014 A2A368 MAGBG_HUMAN 58.261 0.947514 1.11728 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Indicus|evm.model.CM009520.1.1016 A2A368 MAGBG_HUMAN 63.438 0.99373 0.984568 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Indicus|evm.model.CM009520.1.1019 Q5W0B1 OBI1_HUMAN 77.542 0.974138 0.319559 OBI1 - ORC ubiquitin ligase 1 - Homo sapiens (Human) - OBI1 gene E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). Indicus|evm.model.CM009520.1.1020 Q9BQJ4 TMM47_HUMAN 74.033 0.985185 0.745856 TMEM47 - Transmembrane protein 47 - Homo sapiens (Human) - TMEM47 gene Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity). Indicus|evm.model.CM009520.1.1021 Q5R8J7 FRIH_PONAB 66.860 0.934426 1 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Indicus|evm.model.CM009520.1.1024 Q5R1W5 SRSF2_PANTR 64.646 0.502564 0.882353 SRSF2 - Serine/arginine-rich splicing factor 2 - Pan troglodytes (Chimpanzee) - SRSF2 gene Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity). Indicus|evm.model.CM009520.1.1025 Q576B4 NU5M_BOSIN 90.598 0.983051 0.194719 MT-ND5 - NADH-ubiquinone oxidoreductase chain 5 - Bos indicus (Zebu) - MT-ND5 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Indicus|evm.model.CM009520.1.1026 Q5GN48 DMD_PIG 92.214 0.991228 0.372346 DMD - Dystrophin - Sus scrofa (Pig) - DMD gene Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. Indicus|evm.model.CM009520.1.1027 Q5GN48 DMD_PIG 98.492 0.998117 0.289058 DMD - Dystrophin - Sus scrofa (Pig) - DMD gene Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. Indicus|evm.model.CM009520.1.1028 Q5R8J7 FRIH_PONAB 45.902 0.942408 1.04372 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Indicus|evm.model.CM009520.1.1029 Q3ZBM7 TRPT1_BOVIN 59.589 0.726316 0.748031 TRPT1 - tRNA 2'-phosphotransferase 1 - Bos taurus (Bovine) - TRPT1 gene Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. Indicus|evm.model.CM009520.1.1030 Q8N5C8 TAB3_HUMAN 96.739 0.172348 0.741573 TAB3 - TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 - Homo sapiens (Human) - TAB3 gene Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:22158122). Indicus|evm.model.CM009520.1.1031 Q0IID9 GLPK_BOVIN 97.847 0.96737 0.932021 GK - Glycerol kinase - Bos taurus (Bovine) - GK gene Key enzyme in the regulation of glycerol uptake and metabolism. Indicus|evm.model.CM009520.1.1032 Q32LD7 TASL_BOVIN 99.667 0.993355 1.00333 TASL - TLR adapter interacting with SLC15A4 on the lysosome - Bos taurus (Bovine) - TASL gene Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes. Indicus|evm.model.CM009520.1.1033 O95429 BAG4_HUMAN 76.190 0.986486 0.323851 BAG4 - BAG family molecular chaperone regulator 4 - Homo sapiens (Human) - BAG4 gene Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. Indicus|evm.model.CM009520.1.1034 P79386 NR0B1_PIG 81.144 0.995763 1.00212 NR0B1 - Nuclear receptor subfamily 0 group B member 1 - Sus scrofa (Pig) - NR0B1 gene Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Indicus|evm.model.CM009520.1.1035 Q8IXK0 PHC2_HUMAN 74.667 0.367545 0.840326 PHC2 - Polyhomeotic-like protein 2 - Homo sapiens (Human) - PHC2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Indicus|evm.model.CM009520.1.1036 O15480 MAGB3_HUMAN 69.939 0.852632 0.549133 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Indicus|evm.model.CM009520.1.1037 O15481 MAGB4_HUMAN 55.263 0.840796 1.16185 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1039 O15481 MAGB4_HUMAN 54.094 0.739606 1.32081 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1040 O15481 MAGB4_HUMAN 61.413 0.576433 0.907514 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1041 O15481 MAGB4_HUMAN 53.235 0.768879 1.26301 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1042 Q96LZ2 MAGBA_HUMAN 57.377 0.281298 1.86455 MAGEB10 - Melanoma-associated antigen B10 - Homo sapiens (Human) - MAGEB10 gene Indicus|evm.model.CM009520.1.1043 P43366 MAGB1_HUMAN 48.594 0.704678 0.985591 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Indicus|evm.model.CM009520.1.1051 O15481 MAGB4_HUMAN 60.096 0.778195 0.768786 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1053 Q9TTY4 MAGBA_CANLF 77.586 0.232653 0.648148 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Indicus|evm.model.CM009520.1.1054 O15481 MAGB4_HUMAN 61.202 0.271341 1.89595 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1055 Q8IXK0 PHC2_HUMAN 78.967 0.36476 0.754079 PHC2 - Polyhomeotic-like protein 2 - Homo sapiens (Human) - PHC2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Indicus|evm.model.CM009520.1.1056 Q8IXK0 PHC2_HUMAN 87.975 0.299618 0.610723 PHC2 - Polyhomeotic-like protein 2 - Homo sapiens (Human) - PHC2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Indicus|evm.model.CM009520.1.1057 P43366 MAGB1_HUMAN 52.396 0.905045 0.971182 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Indicus|evm.model.CM009520.1.1058 O15480 MAGB3_HUMAN 76.860 0.97561 0.355491 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Indicus|evm.model.CM009520.1.1067 O15480 MAGB3_HUMAN 62.539 0.637624 1.45954 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Indicus|evm.model.CM009520.1.1068 O15479 MAGB2_HUMAN 55.189 0.453763 1.45768 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Indicus|evm.model.CM009520.1.1069 Q16864 VATF_HUMAN 65.546 0.881818 0.92437 ATP6V1F - V-type proton ATPase subunit F - Homo sapiens (Human) - ATP6V1F gene Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Indicus|evm.model.CM009520.1.1073 Q96LZ2 MAGBA_HUMAN 55.975 0.237952 1.91354 MAGEB10 - Melanoma-associated antigen B10 - Homo sapiens (Human) - MAGEB10 gene Indicus|evm.model.CM009520.1.1074 O15479 MAGB2_HUMAN 51.012 0.539823 1.41693 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Indicus|evm.model.CM009520.1.1078 O15481 MAGB4_HUMAN 63.158 0.207339 1.57514 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1079 P59823 IRPL1_MOUSE 81.991 0.975936 0.538129 Il1rapl1 - Interleukin-1 receptor accessory protein-like 1 precursor - Mus musculus (Mouse) - Il1rapl1 gene May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:25908590, PubMed:21940441). Indicus|evm.model.CM009520.1.1080 Q3ZLR7 SP201_HUMAN 56.051 0.311289 1.81896 SUPT20HL1 - Transcription factor SPT20 homolog-like 1 - Homo sapiens (Human) - SUPT20HL1 gene SAGA complex, transcription coregulator activity, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009520.1.1082 Q9TTY4 MAGBA_CANLF 59.236 0.893983 0.92328 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Indicus|evm.model.CM009520.1.1083 Q96LZ2 MAGBA_HUMAN 62.821 0.564165 1.1902 MAGEB10 - Melanoma-associated antigen B10 - Homo sapiens (Human) - MAGEB10 gene Indicus|evm.model.CM009520.1.1084 Q9TTY4 MAGBA_CANLF 60.191 0.896848 0.92328 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Indicus|evm.model.CM009520.1.1086 Q5MIZ7 P4R3B_HUMAN 59.524 0.9677 0.911661 PPP4R3B - Serine/threonine-protein phosphatase 4 regulatory subunit 3B - Homo sapiens (Human) - PPP4R3B gene Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Indicus|evm.model.CM009520.1.1087 Q9ULU4 PKCB1_HUMAN 90.476 0.598854 0.294266 ZMYND8 - Protein kinase C-binding protein 1 - Homo sapiens (Human) - ZMYND8 gene May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion. Indicus|evm.model.CM009520.1.1088 Q9ULU4 PKCB1_HUMAN 85.385 0.444056 0.241147 ZMYND8 - Protein kinase C-binding protein 1 - Homo sapiens (Human) - ZMYND8 gene May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion. Indicus|evm.model.CM009520.1.1089 P31792 POL_FENV1 56.410 0.614973 0.178776 pol - Pol polyprotein - Feline endogenous virus ECE1 - pol gene During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase. Indicus|evm.model.CM009520.1.1090 Q5R7J8 TP4A1_PONAB 55.405 0.982456 0.32948 PTP4A1 - Protein tyrosine phosphatase type IVA 1 precursor - Pongo abelii (Sumatran orangutan) - PTP4A1 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). Indicus|evm.model.CM009520.1.1091 Q9BZ81 MAGB5_HUMAN 58.848 0.65 1.30909 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1092 O15479 MAGB2_HUMAN 55.056 0.569579 0.968652 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Indicus|evm.model.CM009520.1.1093 A2A368 MAGBG_HUMAN 50.000 0.603053 0.808642 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Indicus|evm.model.CM009520.1.1094 Q9BZ81 MAGB5_HUMAN 52.101 0.7 0.981818 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1096 O15481 MAGB4_HUMAN 45.015 0.943396 0.919075 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1097 Q9BZ81 MAGB5_HUMAN 68.333 0.792035 0.821818 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1098 P43366 MAGB1_HUMAN 51.735 0.912791 0.991354 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Indicus|evm.model.CM009520.1.1099 O15479 MAGB2_HUMAN 49.180 0.422535 0.445141 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Indicus|evm.model.CM009520.1.1101 A8MXT2 MAGBH_HUMAN 50.725 0.780303 0.785714 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Indicus|evm.model.CM009520.1.1103 P43366 MAGB1_HUMAN 46.471 0.767123 0.631124 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Indicus|evm.model.CM009520.1.1104 Q9BZ81 MAGB5_HUMAN 68.085 0.985915 0.516364 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1105 A8MXT2 MAGBH_HUMAN 51.485 0.980328 0.907738 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Indicus|evm.model.CM009520.1.1106 P43366 MAGB1_HUMAN 55.479 0.781671 1.06916 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Indicus|evm.model.CM009520.1.1107 O15480 MAGB3_HUMAN 61.429 0.539062 0.369942 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Indicus|evm.model.CM009520.1.1108 Q9BZ81 MAGB5_HUMAN 64.865 0.688213 0.956364 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1109 P43366 MAGB1_HUMAN 51.266 0.912791 0.991354 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Indicus|evm.model.CM009520.1.1110 O15481 MAGB4_HUMAN 47.432 0.89697 0.953757 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1111 A8MXT2 MAGBH_HUMAN 48.746 0.893891 0.925595 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Indicus|evm.model.CM009520.1.1112 Q96M61 MAGBI_HUMAN 60.526 0.274074 0.393586 MAGEB18 - Melanoma-associated antigen B18 - Homo sapiens (Human) - MAGEB18 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Indicus|evm.model.CM009520.1.1117 Q9TTY4 MAGBA_CANLF 74.713 0.197701 1.15079 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Indicus|evm.model.CM009520.1.1118 O15481 MAGB4_HUMAN 51.887 0.920588 0.982659 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1119 O15479 MAGB2_HUMAN 64.348 0.844444 0.423197 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Indicus|evm.model.CM009520.1.1121 Q9BZ81 MAGB5_HUMAN 63.758 0.380463 1.41455 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1122 O15479 MAGB2_HUMAN 54.717 0.613372 1.07837 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Indicus|evm.model.CM009520.1.1123 O15481 MAGB4_HUMAN 76.923 0.955224 0.193642 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1125 P43366 MAGB1_HUMAN 45.732 0.75463 0.622478 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Indicus|evm.model.CM009520.1.1127 Q9BZ81 MAGB5_HUMAN 58.454 0.719858 1.02545 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1128 A8MXT2 MAGBH_HUMAN 51.273 0.992727 0.818452 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Indicus|evm.model.CM009520.1.1129 A8MXT2 MAGBH_HUMAN 48.980 0.945098 0.758929 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Indicus|evm.model.CM009520.1.1130 Q9BZ81 MAGB5_HUMAN 63.547 0.464368 1.58182 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1131 Q9BZ81 MAGB5_HUMAN 64.706 0.333932 2.02545 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1132 Q9BZ81 MAGB5_HUMAN 52.941 0.951613 0.450909 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1134 O15481 MAGB4_HUMAN 53.354 0.949254 0.968208 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1135 A8MXT2 MAGBH_HUMAN 46.735 0.992509 0.794643 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Indicus|evm.model.CM009520.1.1136 Q96M61 MAGBI_HUMAN 65.815 0.900293 0.994169 MAGEB18 - Melanoma-associated antigen B18 - Homo sapiens (Human) - MAGEB18 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Indicus|evm.model.CM009520.1.1137 P54612 2AAA_PIG 82.003 0.99661 1.0017 PPP2R1A - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform - Sus scrofa (Pig) - PPP2R1A gene The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Indicus|evm.model.CM009520.1.1138 P54612 2AAA_PIG 79.796 0.956098 1.04414 PPP2R1A - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform - Sus scrofa (Pig) - PPP2R1A gene The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Indicus|evm.model.CM009520.1.1141 A6YP92 ARX_RAT 98.462 0.820513 0.137809 Arx - Homeobox protein ARX - Rattus norvegicus (Rat) - Arx gene Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity). Indicus|evm.model.CM009520.1.1142 A6YP92 ARX_RAT 100.000 0.894737 0.402827 Arx - Homeobox protein ARX - Rattus norvegicus (Rat) - Arx gene Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity). Indicus|evm.model.CM009520.1.1143 P09884 DPOLA_HUMAN 90.054 0.998639 1.00479 POLA1 - DNA polymerase alpha catalytic subunit - Homo sapiens (Human) - POLA1 gene Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). Indicus|evm.model.CM009520.1.1144 Q811Q9 PCY1B_MOUSE 97.019 0.994595 1.00271 Pcyt1b - Choline-phosphate cytidylyltransferase B - Mus musculus (Mouse) - Pcyt1b gene Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis (PubMed:12842190). Plays an important role in ovary maturation and the maintenance of sperm production (PubMed:15143167). Indicus|evm.model.CM009520.1.1145 Q15120 PDK3_HUMAN 98.522 0.995086 1.00246 PDK3 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial precursor - Homo sapiens (Human) - PDK3 gene Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. Indicus|evm.model.CM009520.1.1146 Q66HC7 SP20H_RAT 59.211 0.650558 1.52264 Supt20h - Transcription factor SPT20 homolog - Rattus norvegicus (Rat) - Supt20h gene Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Indicus|evm.model.CM009520.1.1147 P02793 FRIL1_RAT 49.351 0.539062 0.699454 Ftl1 - Ferritin light chain 1 - Rattus norvegicus (Rat) - Ftl1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.1148 P61247 RS3A_HUMAN 100.000 0.992453 1.00379 RPS3A - 40S ribosomal protein S3a - Homo sapiens (Human) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Indicus|evm.model.CM009520.1.1149 Q7TT00 SP20H_MOUSE 57.553 0.630355 1.54151 Supt20h - Transcription factor SPT20 homolog - Mus musculus (Mouse) - Supt20h gene Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy. Indicus|evm.model.CM009520.1.1150 O62836 ZFX_BOVIN 99.125 0.997503 1.00125 ZFX - Zinc finger X-chromosomal protein - Bos taurus (Bovine) - ZFX gene Probable transcriptional activator. Indicus|evm.model.CM009520.1.1151 Q2KHU8 IF2G_BOVIN 100.000 0.995772 1.00212 EIF2S3 - Eukaryotic translation initiation factor 2 subunit 3 - Bos taurus (Bovine) - EIF2S3 gene As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). Indicus|evm.model.CM009520.1.1152 Q96M94 KLH15_HUMAN 98.510 0.996694 1.00166 KLHL15 - Kelch-like protein 15 - Homo sapiens (Human) - KLHL15 gene Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:14528312). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354). Indicus|evm.model.CM009520.1.1153 Q96LI9 CX058_HUMAN 63.441 0.790598 0.704819 CXorf58 - Putative uncharacterized protein CXorf58 - Homo sapiens (Human) - CXorf58 gene Indicus|evm.model.CM009520.1.1154 Q148H0 MIC26_BOVIN 98.485 0.929245 1.07071 APOO - MICOS complex subunit MIC26 precursor - Bos taurus (Bovine) - APOO gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. Can induce cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Indicus|evm.model.CM009520.1.1155 Q3T0Q0 SAT1_BOVIN 100.000 0.988372 1.00585 SAT1 - Diamine acetyltransferase 1 - Bos taurus (Bovine) - SAT1 gene Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine. Indicus|evm.model.CM009520.1.1156 Q3SWX2 ACOT9_BOVIN 100.000 0.995434 1.00229 ACOT9 - Acyl-coenzyme A thioesterase 9, mitochondrial precursor - Bos taurus (Bovine) - ACOT9 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. Indicus|evm.model.CM009520.1.1157 Q9BGI2 PRDX4_BOVIN 100.000 0.992727 1.00365 PRDX4 - Peroxiredoxin-4 precursor - Bos taurus (Bovine) - PRDX4 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. Indicus|evm.model.CM009520.1.1158 Q920A7 AFG31_MOUSE 77.439 0.795122 0.259823 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Indicus|evm.model.CM009520.1.1159 O46415 FRIL_BOVIN 73.418 0.876404 0.508571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Indicus|evm.model.CM009520.1.1160 Q96NR3 PTHD1_HUMAN 98.911 0.970018 0.638514 PTCHD1 - Patched domain-containing protein 1 - Homo sapiens (Human) - PTCHD1 gene Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention. Indicus|evm.model.CM009520.1.1161 Q96NR3 PTHD1_HUMAN 98.973 0.801653 0.408784 PTCHD1 - Patched domain-containing protein 1 - Homo sapiens (Human) - PTCHD1 gene Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention. Indicus|evm.model.CM009520.1.1162 O15481 MAGB4_HUMAN 54.079 0.947674 0.99422 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1163 Q9NXZ2 DDX43_HUMAN 73.810 0.54881 1.2963 DDX43 - Probable ATP-dependent RNA helicase DDX43 - Homo sapiens (Human) - DDX43 gene RNA binding, RNA helicase activity Indicus|evm.model.CM009520.1.1164 P70081 H48_CHICK 93.220 0.495726 1.13592 H4-VIII - Histone H4 type VIII - Gallus gallus (Chicken) - H4-VIII gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Indicus|evm.model.CM009520.1.1166 Q811Q9 PCY1B_MOUSE 90.625 0.77439 0.444444 Pcyt1b - Choline-phosphate cytidylyltransferase B - Mus musculus (Mouse) - Pcyt1b gene Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis (PubMed:12842190). Plays an important role in ovary maturation and the maintenance of sperm production (PubMed:15143167). Indicus|evm.model.CM009520.1.1167 Q3MHP3 S10AE_BOVIN 79.808 0.980952 1.00962 S100A14 - Protein S100-A14 - Bos taurus (Bovine) - S100A14 gene Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity). Indicus|evm.model.CM009520.1.1168 A0A1B0GWH4 HSFX3_HUMAN 48.485 0.519068 1.41742 HSFX3 - Heat shock transcription factor, X-linked member 3 - Homo sapiens (Human) - HSFX3 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Indicus|evm.model.CM009520.1.1171 P70669 PHEX_MOUSE 95.018 0.903226 0.413885 Phex - Phosphate-regulating neutral endopeptidase PHEX - Mus musculus (Mouse) - Phex gene Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (By similarity). Cleaves ASARM peptides between Ser and Glu or Asp residues (By similarity). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:11159866, PubMed:18597632, PubMed:26051469). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:26051469). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (By similarity). Indicus|evm.model.CM009520.1.1172 P62958 HINT1_BOVIN 98.413 0.984252 1.00794 HINT1 - Histidine triad nucleotide-binding protein 1 - Bos taurus (Bovine) - HINT1 gene Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Indicus|evm.model.CM009520.1.1173 P78562 PHEX_HUMAN 82.780 0.929752 0.646195 PHEX - Phosphate-regulating neutral endopeptidase PHEX - Homo sapiens (Human) - PHEX gene Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (PubMed:9593714, PubMed:15664000, PubMed:18162525, PubMed:18597632). Cleaves ASARM peptides between Ser and Glu or Asp residues (PubMed:18597632). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:18597632). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:18597632, PubMed:18162525). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (PubMed:12220505). Indicus|evm.model.CM009520.1.1174 Q3SZA5 SPSY_BOVIN 95.266 0.993994 0.912329 SMS - Spermine synthase - Bos taurus (Bovine) - SMS gene Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). Indicus|evm.model.CM009520.1.1175 O75140 DEPD5_HUMAN 86.486 0.973333 0.0467873 DEPDC5 - GATOR complex protein DEPDC5 - Homo sapiens (Human) - DEPDC5 gene As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. Indicus|evm.model.CM009520.1.1176 Q0III2 MBTP2_BOVIN 99.421 0.996146 1.00581 MBTPS2 - Membrane-bound transcription factor site-2 protease - Bos taurus (Bovine) - MBTPS2 gene Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. Indicus|evm.model.CM009520.1.1177 Q3ZBD4 SMPX_BOVIN 100.000 0.977011 1.01163 SMPX - Small muscular protein - Bos taurus (Bovine) - SMPX gene Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. Indicus|evm.model.CM009520.1.1178 Q8N239 KLH34_HUMAN 87.191 0.992331 1.01242 KLHL34 - Kelch-like protein 34 - Homo sapiens (Human) - KLHL34 gene extracellular space Indicus|evm.model.CM009520.1.1179 Q8WXI2 CNKR2_HUMAN 94.498 0.997976 0.955513 CNKSR2 - Connector enhancer of kinase suppressor of ras 2 - Homo sapiens (Human) - CNKSR2 gene May function as an adapter protein or regulator of Ras signaling pathways. Indicus|evm.model.CM009520.1.1180 Q76B49 CD63_FELCA 67.373 0.928 1.05042 CD63 - CD63 antigen - Felis catus (Cat) - CD63 gene Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity). Indicus|evm.model.CM009520.1.1182 Q76LV1 HS90B_BOVIN 85.922 0.99684 0.874309 HSP90AB1 - Heat shock protein HSP 90-beta - Bos taurus (Bovine) - HSP90AB1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10. Indicus|evm.model.CM009520.1.1183 P18654 KS6A3_MOUSE 100.000 0.997301 1.00135 Rps6ka3 - Ribosomal protein S6 kinase alpha-3 - Mus musculus (Mouse) - Rps6ka3 gene Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10856237, PubMed:15109498). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (By similarity). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (By similarity). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (By similarity). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (By similarity). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (By similarity). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (By similarity). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (By similarity). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:14504289). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (PubMed:17785202, PubMed:17906627). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (PubMed:22827337). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (PubMed:22827337). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (By similarity). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (PubMed:15109498). Indicus|evm.model.CM009520.1.1184 Q5RA42 IF1AX_PONAB 100.000 0.986207 1.00694 EIF1AX - Eukaryotic translation initiation factor 1A, X-chromosomal - Pongo abelii (Sumatran orangutan) - EIF1AX gene Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity). Indicus|evm.model.CM009520.1.1185 Q96B97 SH3K1_HUMAN 95.710 0.996705 0.912782 SH3KBP1 - SH3 domain-containing kinase-binding protein 1 - Homo sapiens (Human) - SH3KBP1 gene Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). Indicus|evm.model.CM009520.1.1186 Q6ZN16 M3K15_HUMAN 88.240 0.989873 0.902513 MAP3K15 - Mitogen-activated protein kinase kinase kinase 15 - Homo sapiens (Human) - MAP3K15 gene May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. Indicus|evm.model.CM009520.1.1187 A7MB35 ODPA_BOVIN 100.000 0.994885 1.00256 PDHA1 - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor - Bos taurus (Bovine) - PDHA1 gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Indicus|evm.model.CM009520.1.1188 P0DKL9 A14EL_HUMAN 58.553 0.986842 1 ARL14EPL - ARL14 effector protein-like - Homo sapiens (Human) - ARL14EPL gene Indicus|evm.model.CM009520.1.1189 P0DKL9 A14EL_HUMAN 60.526 0.986842 1 ARL14EPL - ARL14 effector protein-like - Homo sapiens (Human) - ARL14EPL gene Indicus|evm.model.CM009520.1.1190 P0DKL9 A14EL_HUMAN 61.333 0.973684 1 ARL14EPL - ARL14 effector protein-like - Homo sapiens (Human) - ARL14EPL gene Indicus|evm.model.CM009520.1.1191 P0DKL9 A14EL_HUMAN 45.082 0.89313 0.861842 ARL14EPL - ARL14 effector protein-like - Homo sapiens (Human) - ARL14EPL gene Indicus|evm.model.CM009520.1.1192 Q8IZP9 AGRG2_HUMAN 82.664 0.998014 0.990167 ADGRG2 - Adhesion G-protein coupled receptor G2 precursor - Homo sapiens (Human) - ADGRG2 gene Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis. Indicus|evm.model.CM009520.1.1193 P46019 KPB2_HUMAN 92.227 0.998344 0.978138 PHKA2 - Phosphorylase b kinase regulatory subunit alpha, liver isoform - Homo sapiens (Human) - PHKA2 gene Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. Indicus|evm.model.CM009520.1.1194 O14829 PPE1_HUMAN 75.846 0.99232 0.996937 PPEF1 - Serine/threonine-protein phosphatase with EF-hands 1 - Homo sapiens (Human) - PPEF1 gene May have a role in the recovery or adaptation response of photoreceptors. May have a role in development. Indicus|evm.model.CM009520.1.1195 O15537 XLRS1_HUMAN 95.477 0.933962 0.946429 RS1 - Retinoschisin precursor - Homo sapiens (Human) - RS1 gene Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009). Indicus|evm.model.CM009520.1.1196 O76039 CDKL5_HUMAN 96.478 0.963592 0.858333 CDKL5 - Cyclin-dependent kinase-like 5 - Homo sapiens (Human) - CDKL5 gene Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). Indicus|evm.model.CM009520.1.1197 Q9UQR0 SCML2_HUMAN 73.617 0.997167 1.00857 SCML2 - Sex comb on midleg-like protein 2 - Homo sapiens (Human) - SCML2 gene Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). Indicus|evm.model.CM009520.1.1198 Q8NDZ0 BEND2_HUMAN 41.597 0.524245 1.36796 BEND2 - BEN domain-containing protein 2 - Homo sapiens (Human) - BEND2 gene Indicus|evm.model.CM009520.1.1199 Q9UHC7 MKRN1_HUMAN 84.483 0.178914 0.649378 MKRN1 - E3 ubiquitin-protein ligase makorin-1 - Homo sapiens (Human) - MKRN1 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. Indicus|evm.model.CM009520.1.1200 P22451 RL5_CHICK 49.057 0.602339 0.575758 RPL5 - 60S ribosomal protein L5 - Gallus gallus (Chicken) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Indicus|evm.model.CM009520.1.1201 Q9Y5P3 RAI2_HUMAN 92.347 0.372137 0.988679 RAI2 - Retinoic acid-induced protein 2 - Homo sapiens (Human) - RAI2 gene embryo development ending in birth or egg hatching Indicus|evm.model.CM009520.1.1203 Q6T4R5 NHS_HUMAN 93.000 0.0672098 0.892187 NHS - Nance-Horan syndrome protein - Homo sapiens (Human) - NHS gene May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. Indicus|evm.model.CM009520.1.1204 Q6T4R5 NHS_HUMAN 74.346 0.943005 0.116899 NHS - Nance-Horan syndrome protein - Homo sapiens (Human) - NHS gene May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. Indicus|evm.model.CM009520.1.1205 P34826 EF1B_RABIT 58.000 0.534884 0.573333 EEF1B - Elongation factor 1-beta - Oryctolagus cuniculus (Rabbit) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Indicus|evm.model.CM009520.1.1207 Q8NFH8 REPS2_HUMAN 92.391 0.970402 0.716667 REPS2 - RalBP1-associated Eps domain-containing protein 2 - Homo sapiens (Human) - REPS2 gene Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:9422736, PubMed:12771942, PubMed:10393179). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). Indicus|evm.model.CM009520.1.1208 Q3SWX8 RBBP7_BOVIN 99.762 0.891489 1.10588 RBBP7 - Histone-binding protein RBBP7 - Bos taurus (Bovine) - RBBP7 gene Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity). Indicus|evm.model.CM009520.1.1209 Q9NUQ3 TXLNG_HUMAN 85.876 0.996101 0.971591 TXLNG - Gamma-taxilin - Homo sapiens (Human) - TXLNG gene May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. Indicus|evm.model.CM009520.1.1210 Q96A49 SYAP1_HUMAN 86.313 0.994429 1.01989 SYAP1 - Synapse-associated protein 1 - Homo sapiens (Human) - SYAP1 gene Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). Indicus|evm.model.CM009520.1.1211 Q1RMS2 PYRG2_BOVIN 94.198 0.996396 0.947099 CTPS2 - CTP synthase 2 - Bos taurus (Bovine) - CTPS2 gene Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Indicus|evm.model.CM009520.1.1212 Q5R8X2 DUS18_PONAB 73.214 0.433071 0.675532 DUSP18 - Dual specificity protein phosphatase 18 - Pongo abelii (Sumatran orangutan) - DUSP18 gene Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). Indicus|evm.model.CM009520.1.1213 O75529 TAF5L_HUMAN 77.446 0.996672 1.02037 TAF5L - TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L - Homo sapiens (Human) - TAF5L gene Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity). Indicus|evm.model.CM009520.1.1214 P52500 GRPR_RAT 94.561 0.991667 0.625 Grpr - Gastrin-releasing peptide receptor - Rattus norvegicus (Rat) - Grpr gene Receptor for gastrin-releasing peptide (GRP) (PubMed:8391296). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Indicus|evm.model.CM009520.1.1215 P30550 GRPR_HUMAN 88.356 0.387701 0.973958 GRPR - Gastrin-releasing peptide receptor - Homo sapiens (Human) - GRPR gene Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity). Indicus|evm.model.CM009520.1.1216 Q9Y2D0 CAH5B_HUMAN 86.364 0.783133 0.26183 CA5B - Carbonic anhydrase 5B, mitochondrial precursor - Homo sapiens (Human) - CA5B gene Reversible hydration of carbon dioxide. Indicus|evm.model.CM009520.1.1217 Q9DB50 AP1S2_MOUSE 100.000 0.987578 1.00625 Ap1s2 - AP-1 complex subunit sigma-2 - Mus musculus (Mouse) - Ap1s2 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). Indicus|evm.model.CM009520.1.1218 Q15696 U2AFM_HUMAN 87.059 0.904051 0.973029 ZRSR2 - U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 - Homo sapiens (Human) - ZRSR2 gene Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. Indicus|evm.model.CM009520.1.1219 Q9Y2D0 CAH5B_HUMAN 90.536 0.993711 1.00315 CA5B - Carbonic anhydrase 5B, mitochondrial precursor - Homo sapiens (Human) - CA5B gene Reversible hydration of carbon dioxide. Indicus|evm.model.CM009520.1.1221 Q0VCT4 CLTRN_BOVIN 100.000 0.950311 0.725225 CLTRN - Collectrin precursor - Bos taurus (Bovine) - CLTRN gene Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (By similarity). Stimulator of beta cell replication (By similarity). Indicus|evm.model.CM009520.1.1222 Q58DD0 ACE2_BOVIN 99.481 0.948276 1.00995 ACE2 - Angiotensin-converting enzyme 2 precursor - Bos taurus (Bovine) - ACE2 gene Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity. Indicus|evm.model.CM009520.1.1223 P97504 BMX_MOUSE 89.399 0.781908 1.23963 Bmx - Cytoplasmic tyrosine-protein kinase BMX - Mus musculus (Mouse) - Bmx gene Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. Indicus|evm.model.CM009520.1.1224 O00625 PIR_HUMAN 80.208 0.988142 0.872414 PIR - Pirin - Homo sapiens (Human) - PIR gene Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). Indicus|evm.model.CM009520.1.1225 P37287 PIGA_HUMAN 94.384 0.581864 1.6405 PIGA - Phosphatidylinositol N-acetylglucosaminyltransferase subunit A - Homo sapiens (Human) - PIGA gene Catalytic subunit of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Indicus|evm.model.CM009520.1.1226 Q3SZE4 ASB11_BOVIN 99.336 0.958466 0.96904 ASB11 - Ankyrin repeat and SOCS box protein 11 - Bos taurus (Bovine) - ASB11 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Indicus|evm.model.CM009520.1.1227 Q96DX5 ASB9_HUMAN 75.850 0.993056 0.979592 ASB9 - Ankyrin repeat and SOCS box protein 9 - Homo sapiens (Human) - ASB9 gene Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A. Indicus|evm.model.CM009520.1.1228 Q8NHP6 MSPD2_HUMAN 88.996 0.984762 1.01351 MOSPD2 - Motile sperm domain-containing protein 2 - Homo sapiens (Human) - MOSPD2 gene Endoplasmic reticulum-anchored receptor which modulates interorganelle contacts by interacting with other organelle-bound proteins via their FFAT motif (PubMed:29858488). Might have a more important role in endoplasmic reticulum and endosomes contacts (PubMed:29858488). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). Indicus|evm.model.CM009520.1.1229 Q8NB91 FANCB_HUMAN 69.708 0.997655 0.993015 FANCB - Fanconi anemia group B protein - Homo sapiens (Human) - FANCB gene DNA repair protein required for FANCD2 ubiquitination. Indicus|evm.model.CM009520.1.1231 Q7TNC8 GLRA2_MOUSE 99.174 0.994505 0.80531 Glra2 - Glycine receptor subunit alpha-2 precursor - Mus musculus (Mouse) - Glra2 gene Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Plays a role in cellular responses to ethanol. Indicus|evm.model.CM009520.1.1234 Q1LZ79 GEMI8_BOVIN 100.000 0.991489 1.00427 GEMIN8 - Gem-associated protein 8 - Bos taurus (Bovine) - GEMIN8 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity). Indicus|evm.model.CM009520.1.1235 P35803 GPM6B_MOUSE 97.866 0.993921 1.00305 Gpm6b - Neuronal membrane glycoprotein M6-b - Mus musculus (Mouse) - Gpm6b gene May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. Indicus|evm.model.CM009520.1.1236 O75665 OFD1_HUMAN 70.780 0.998008 0.992095 OFD1 - Oral-facial-digital syndrome 1 protein - Homo sapiens (Human) - OFD1 gene Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). Indicus|evm.model.CM009520.1.1237 F1SRI0 TPPC2_PIG 92.715 0.986842 1.08571 TRAPPC2 - Trafficking protein particle complex subunit 2 - Sus scrofa (Pig) - TRAPPC2 gene Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Indicus|evm.model.CM009520.1.1238 P51151 RAB9A_HUMAN 97.512 0.980392 1.01493 RAB9A - Ras-related protein Rab-9A - Homo sapiens (Human) - RAB9A gene Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Indicus|evm.model.CM009520.1.1239 Q8N8B7 TEANC_HUMAN 68.750 0.926121 1.07977 TCEANC - Transcription elongation factor A N-terminal and central domain-containing protein - Homo sapiens (Human) - TCEANC gene Indicus|evm.model.CM009520.1.1240 Q8IUX8 EGFL6_HUMAN 71.233 0.422059 1.22966 EGFL6 - Epidermal growth factor-like protein 6 precursor - Homo sapiens (Human) - EGFL6 gene May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity). Indicus|evm.model.CM009520.1.1242 Q9BZ81 MAGB5_HUMAN 70.175 0.982609 0.418182 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1243 Q9TTY4 MAGBA_CANLF 72.059 0.204893 0.865079 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Indicus|evm.model.CM009520.1.1245 P02817 AMELX_BOVIN 97.802 0.967914 0.877934 AMELX - Amelogenin, X isoform precursor - Bos taurus (Bovine) - AMELX gene Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. Indicus|evm.model.CM009520.1.1246 O43182 RHG06_HUMAN 85.204 0.997449 0.804928 ARHGAP6 - Rho GTPase-activating protein 6 - Homo sapiens (Human) - ARHGAP6 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. Indicus|evm.model.CM009520.1.1247 A5PJG7 CCHL_BOVIN 100.000 0.992754 1.00364 HCCS - Holocytochrome c-type synthase - Bos taurus (Bovine) - HCCS gene Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome. Indicus|evm.model.CM009520.1.1249 Q9JJZ5 EGFL6_MOUSE 79.545 0.550633 0.287273 Egfl6 - Epidermal growth factor-like protein 6 precursor - Mus musculus (Mouse) - Egfl6 gene May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly. Indicus|evm.model.CM009520.1.1250 O15481 MAGB4_HUMAN 58.197 0.462428 1.5 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1254 Q9TTY4 MAGBA_CANLF 75.229 0.739726 0.386243 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Indicus|evm.model.CM009520.1.1255 Q9BZ81 MAGB5_HUMAN 64.706 0.673469 1.24727 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1256 O15481 MAGB4_HUMAN 72.727 0.628099 0.349711 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Indicus|evm.model.CM009520.1.1257 Q9BZ81 MAGB5_HUMAN 68.487 0.679083 1.26909 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1258 Q96M61 MAGBI_HUMAN 71.014 0.647619 0.306122 MAGEB18 - Melanoma-associated antigen B18 - Homo sapiens (Human) - MAGEB18 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Indicus|evm.model.CM009520.1.1260 O43930 PRKY_HUMAN 87.963 0.667702 1.16245 PRKY - Putative serine/threonine-protein kinase PRKY - Homo sapiens (Human) - PRKY gene cAMP-dependent protein kinase complex, cAMP-dependent protein kinase activity, protein serine/threonine kinase activity, peptidyl-serine phosphorylation, protein phosphorylation, signal transduction Indicus|evm.model.CM009520.1.1261 Q9NR99 MXRA5_HUMAN 68.801 0.995437 1.00743 MXRA5 - Matrix-remodeling-associated protein 5 precursor - Homo sapiens (Human) - MXRA5 gene In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. Indicus|evm.model.CM009520.1.1262 Q32KH8 ARSH_CANLF 84.342 0.938127 1.06406 ARSH - Arylsulfatase H - Canis lupus familiaris (Dog) - ARSH gene arylsulfatase activity Indicus|evm.model.CM009520.1.1263 P51690 ARSL_HUMAN 75.424 0.996593 0.996604 ARSL - Arylsulfatase L precursor - Homo sapiens (Human) - ARSL gene May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. Indicus|evm.model.CM009520.1.1264 P51689 ARSD_HUMAN 79.769 0.858209 0.677909 ARSD - Arylsulfatase D precursor - Homo sapiens (Human) - ARSD gene endoplasmic reticulum lumen, arylsulfatase activity Indicus|evm.model.CM009520.1.1265 P51689 ARSD_HUMAN 84.706 0.792453 0.178752 ARSD - Arylsulfatase D precursor - Homo sapiens (Human) - ARSD gene endoplasmic reticulum lumen, arylsulfatase activity Indicus|evm.model.CM009520.1.1267 Q9BZ81 MAGB5_HUMAN 71.622 0.563218 0.949091 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Indicus|evm.model.CM009520.1.1268 Q9TTY4 MAGBA_CANLF 70.588 0.638095 0.277778 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Indicus|evm.model.CM009520.1.1269 Q9GMV6 TEANC_MACFA 64.478 0.937677 1.00857 TCEANC - Transcription elongation factor A N-terminal and central domain-containing protein - Macaca fascicularis (Crab-eating macaque) - TCEANC gene Indicus|evm.model.CM009520.1.1270 O15344 TRI18_HUMAN 98.801 0.997006 1.0015 MID1 - E3 ubiquitin-protein ligase Midline-1 - Homo sapiens (Human) - MID1 gene Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. Indicus|evm.model.CM009520.1.1272 P51689 ARSD_HUMAN 67.769 0.857143 0.236088 ARSD - Arylsulfatase D precursor - Homo sapiens (Human) - ARSD gene endoplasmic reticulum lumen, arylsulfatase activity Indicus|evm.model.CM009520.1.1273 O15488 GLYG2_HUMAN 67.516 0.547733 1.67265 GYG2 - Glycogenin-2 - Homo sapiens (Human) - GYG2 gene Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. Indicus|evm.model.CM009520.1.1274 Q5RE35 C99L2_PONAB 52.500 0.203209 0.857798 CD99L2 - CD99 antigen-like protein 2 precursor - Pongo abelii (Sumatran orangutan) - CD99L2 gene Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). Indicus|evm.model.CM009520.1.1275 O96006 ZBED1_HUMAN 81.746 0.995253 0.910663 ZBED1 - E3 SUMO-protein ligase ZBED1 - Homo sapiens (Human) - ZBED1 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279). Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). Indicus|evm.model.CM009520.1.1276 Q8N5I4 DHRSX_HUMAN 79.310 0.564356 0.306061 DHRSX - Dehydrogenase/reductase SDR family member on chromosome X - Homo sapiens (Human) - DHRSX gene Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851). Indicus|evm.model.CM009520.1.1277 Q8N5I4 DHRSX_HUMAN 74.046 0.849673 0.463636 DHRSX - Dehydrogenase/reductase SDR family member on chromosome X - Homo sapiens (Human) - DHRSX gene Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851). Indicus|evm.model.CM009520.1.1278 Q8N8B7 TEANC_HUMAN 66.382 0.925926 1.07692 TCEANC - Transcription elongation factor A N-terminal and central domain-containing protein - Homo sapiens (Human) - TCEANC gene Indicus|evm.model.CM009520.1.1279 Q2HJ51 RA51D_BOVIN 51.682 0.987288 0.723926 RAD51D - DNA repair protein RAD51 homolog 4 - Bos taurus (Bovine) - RAD51D gene Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM (By similarity). Indicus|evm.model.CM009520.1.1281 Q9NR97 TLR8_HUMAN 74.110 0.998066 0.993276 TLR8 - Toll-like receptor 8 precursor - Homo sapiens (Human) - TLR8 gene Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses (PubMed:33718825). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371, PubMed:33718825). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428). Indicus|evm.model.CM009520.1.1282 Q9NYK1 TLR7_HUMAN 86.476 0.998097 1.00191 TLR7 - Toll-like receptor 7 precursor - Homo sapiens (Human) - TLR7 gene Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:31608988, PubMed:27742543, PubMed:12738885, PubMed:32706371). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371). Indicus|evm.model.CM009520.1.1283 P09330 PRPS2_RAT 99.020 0.990244 0.644654 Prps2 - Ribose-phosphate pyrophosphokinase 2 - Rattus norvegicus (Rat) - Prps2 gene Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Indicus|evm.model.CM009520.1.1284 Q5R8F8 PRPS2_PONAB 99.020 0.691781 0.459119 PRPS2 - Ribose-phosphate pyrophosphokinase 2 - Pongo abelii (Sumatran orangutan) - PRPS2 gene Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Indicus|evm.model.CM009520.1.1285 Q14CM0 FRPD4_HUMAN 90.110 0.63412 1.40998 FRMPD4 - FERM and PDZ domain-containing protein 4 - Homo sapiens (Human) - FRMPD4 gene Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. Indicus|evm.model.CM009520.1.1287 Q8N5Y2 MS3L1_HUMAN 94.251 0.985772 0.944338 MSL3 - Male-specific lethal 3 homolog - Homo sapiens (Human) - MSL3 gene Has a role in chromatin remodeling and transcriptional regulation (PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647). Has a role in X inactivation (PubMed:21217699). Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure (PubMed:16227571, PubMed:20657587, PubMed:16543150, PubMed:30224647). Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). Indicus|evm.model.CM009520.1.1288 O43182 RHG06_HUMAN 85.714 0.901408 0.218686 ARHGAP6 - Rho GTPase-activating protein 6 - Homo sapiens (Human) - ARHGAP6 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. Indicus|evm.model.CM009520.1.1289 P49840 GSK3A_HUMAN 79.310 0.966292 0.184265 GSK3A - Glycogen synthase kinase-3 alpha - Homo sapiens (Human) - GSK3A gene Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Indicus|evm.model.CM009520.1.1291 Q93008 USP9X_HUMAN 95.253 0.48913 0.504307 USP9X - Probable ubiquitin carboxyl-terminal hydrolase FAF-X - Homo sapiens (Human) - USP9X gene Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed:16322459, PubMed:18254724, PubMed:19135894, PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed:29626158). Indicus|evm.model.CM009520.1.1292 Q15696 U2AFM_HUMAN 82.105 0.820809 0.717842 ZRSR2 - U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 - Homo sapiens (Human) - ZRSR2 gene Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. Indicus|evm.model.CM009520.1.1294 P51793 CLCN4_HUMAN 97.763 0.997372 1.00132 CLCN4 - H(+)/Cl(-) exchange transporter 4 - Homo sapiens (Human) - CLCN4 gene Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:18063579, PubMed:28972156, PubMed:23647072, PubMed:27550844, PubMed:25644381). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874). Indicus|evm.model.CM009520.1.1295 Q9ULE0 WWC3_HUMAN 83.726 0.854754 1.04029 WWC3 - Protein WWC3 - Homo sapiens (Human) - WWC3 gene cytosol, kinase binding, molecular adaptor activity, negative regulation of hippo signaling, negative regulation of organ growth, negative regulation of transcription by RNA polymerase II Indicus|evm.model.CM009520.1.1296 Q9NQV7 PRDM9_HUMAN 65.217 0.776786 0.12528 PRDM9 - Histone-lysine N-methyltransferase PRDM9 - Homo sapiens (Human) - PRDM9 gene Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:24634223, PubMed:24095733, PubMed:26833727). Also can methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24095733, PubMed:24634223, PubMed:26833727). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (By similarity). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:26833727). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (By similarity). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (By similarity). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (By similarity). In addition performs automethylation (By similarity). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (By similarity). Indicus|evm.model.CM009520.1.1298 Q9CRB3 HIUH_MOUSE 66.667 0.0946237 3.94068 Urah - 5-hydroxyisourate hydrolase - Mus musculus (Mouse) - Urah gene Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). Indicus|evm.model.CM009520.1.1301 P79457 UTY_MOUSE 84.354 0.336134 1.08003 Uty - Histone demethylase UTY - Mus musculus (Mouse) - Uty gene Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low KDM activity. Indicus|evm.model.CM009520.1.1302 Q5RF43 DDX3Y_PONAB 88.654 0.996979 1.00608 DDX3Y - ATP-dependent RNA helicase DDX3Y - Pongo abelii (Sumatran orangutan) - DDX3Y gene Probable ATP-dependent RNA helicase. May play a role in spermatogenesis (By similarity). Indicus|evm.model.CM009520.1.1303 Q9NUJ7 PLCX1_HUMAN 57.321 0.987138 0.962848 PLCXD1 - PI-PLC X domain-containing protein 1 - Homo sapiens (Human) - PLCXD1 gene Indicus|evm.model.CM009520.1.1304 Q96EQ9 PRDM9_MOUSE 72.468 0.30086 1.24199 Prdm9 - Histone-lysine N-methyltransferase PRDM9 - Mus musculus (Mouse) - Prdm9 gene Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:16292313, PubMed:24095733, PubMed:27362481, PubMed:24785241, PubMed:29478809). Also can methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24785241, PubMed:27362481). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (PubMed:24785241, PubMed:27362481). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:22028627, PubMed:27362481, PubMed:29478809). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (PubMed:16292313, PubMed:29478809). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema (PubMed:27932493). EWSR1 joins PRDM9 with the chromosomal axis through REC8 (PubMed:27932493). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (PubMed:25894966, PubMed:16292313). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (PubMed:16292313). In addition performs automethylation (PubMed:28126738). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (PubMed:27362481). Indicus|evm.model.CM009520.1.1306 Q13796 SHRM2_HUMAN 66.667 0.970085 0.144802 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Indicus|evm.model.CM009520.1.1307 Q13796 SHRM2_HUMAN 90.000 0.828704 0.133663 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Indicus|evm.model.CM009520.1.1308 O19110 TSPY1_BOVIN 55.556 0.25102 1.54574 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Indicus|evm.model.CM009520.1.1309 Q9NUJ7 PLCX1_HUMAN 55.747 0.837379 1.27554 PLCXD1 - PI-PLC X domain-containing protein 1 - Homo sapiens (Human) - PLCXD1 gene Indicus|evm.model.CM009520.1.1310 H7C241 CLD34_HUMAN 48.571 0.96729 1 CLDN34 - Claudin-34 - Homo sapiens (Human) - CLDN34 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Indicus|evm.model.CM009520.1.1311 Q13796 SHRM2_HUMAN 77.637 0.192504 0.726485 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Indicus|evm.model.CM009520.1.1312 P51810 GP143_HUMAN 66.908 0.972973 1.00743 GPR143 - G-protein coupled receptor 143 - Homo sapiens (Human) - GPR143 gene Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. Indicus|evm.model.CM009520.1.1313 Q99004 AMELY_BOVIN 99.320 0.138258 5.5 AMELY - Amelogenin, Y isoform precursor - Bos taurus (Bovine) - AMELY gene Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. Indicus|evm.model.CM009520.1.1314 Q6VV72 IF1A_RAT 87.023 0.902778 1 Eif1a - Eukaryotic translation initiation factor 1A - Rattus norvegicus (Rat) - Eif1a gene Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity). Indicus|evm.model.CM009520.1.1315 Q13796 SHRM2_HUMAN 96.364 0.683544 0.0488861 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Indicus|evm.model.CM009520.1.1317 P81795 IF2G_RAT 97.650 0.985232 1.00424 Eif2s3 - Eukaryotic translation initiation factor 2 subunit 3, X-linked - Rattus norvegicus (Rat) - Eif2s3 gene As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). Indicus|evm.model.CM009520.1.1319 P08548 LIN1_NYCCO 57.219 0.865116 0.170635 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Indicus|evm.model.CM009520.1.1320 Q9QXE7 TBL1X_MOUSE 88.994 0.861063 1.10626 Tbl1x - F-box-like/WD repeat-containing protein TBL1X - Mus musculus (Mouse) - Tbl1x gene F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity). Indicus|evm.model.CM009520.1.1323 P23352 KALM_HUMAN 81.270 0.996721 0.897059 ANOS1 - Anosmin-1 precursor - Homo sapiens (Human) - ANOS1 gene Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. Indicus|evm.model.CM009520.1.1329 P41247 PLPL4_HUMAN 89.011 0.483871 0.735178 PNPLA4 - Patatin-like phospholipase domain-containing protein 4 - Homo sapiens (Human) - PNPLA4 gene Has abundant triacylglycerol lipase activity (PubMed:15364929). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Indicus|evm.model.CM009520.1.1330 P08842 STS_HUMAN 77.643 0.994819 0.993139 STS - Steryl-sulfatase precursor - Homo sapiens (Human) - STS gene Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. Indicus|evm.model.CM009520.1.1331 Q08623 HDHD1_HUMAN 79.808 0.665595 1.36404 PUDP - Pseudouridine-5'-phosphatase - Homo sapiens (Human) - PUDP gene Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine. Indicus|evm.model.CM009520.1.1333 Q8N0W4 NLGNX_HUMAN 98.187 0.966276 0.835784 NLGN4X - Neuroligin-4, X-linked precursor - Homo sapiens (Human) - NLGN4X gene Putative neuronal cell surface protein involved in cell-cell-interactions. Indicus|evm.model.CM009520.1.1335 Q28133 ALL2_BOVIN 99.401 0.666667 1.44767 Allergen Bos d 2 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.1336 Q28133 ALL2_BOVIN 62.136 0.215645 2.75 Allergen Bos d 2 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.1337 Q28133 ALL2_BOVIN 52.985 0.93007 0.831395 Allergen Bos d 2 precursor - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.1340 P07435 OBP_BOVIN 60.145 0.144667 5.95597 Odorant-binding protein - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.1341 P07435 OBP_BOVIN 94.737 0.639831 1.48428 Odorant-binding protein - Bos taurus (Bovine) Indicus|evm.model.CM009520.1.1342 Q02040 AK17A_HUMAN 96.651 0.958525 0.31223 AKAP17A - A-kinase anchor protein 17A - Homo sapiens (Human) - AKAP17A gene Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. Indicus|evm.model.CM009520.1.1343 Q86VZ1 P2RY8_HUMAN 85.470 0.386667 0.835655 P2RY8 - P2Y purinoceptor 8 - Homo sapiens (Human) - P2RY8 gene Probable receptor for purines coupled to G-proteins. Indicus|evm.model.PRDE01000030.1.2 P03924 NU6M_BOVIN 98.387 0.924812 0.76 MT-ND6 - NADH-ubiquinone oxidoreductase chain 6 - Bos taurus (Bovine) - MT-ND6 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Indicus|evm.model.PRDE01000061.1.1 Q6RFH8 DUX4C_HUMAN 68.293 0.634921 0.168449 DUX4L9 - Double homeobox protein 4C - Homo sapiens (Human) - DUX4L9 gene May be involved in transcriptional regulation (By similarity). Down-regulates MYOD1 expression and may up-regulate MYF5 expression. May regulate microRNA (miRNA) transcription, upregulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206. Impairs the differentiation of myoblasts and may be involved in muscle regeneration. Indicus|evm.model.PRDE01000066.1.2 P50359 Y4HO_SINFN 51.852 0.930435 1 NGR_a03350 - Uncharacterized protein y4hO - Sinorhizobium fredii (strain NBRC 101917 / NGR234) - NGR_a03350 gene Indicus|evm.model.PRDE01000070.1.1 P42206 GUDD_PSEPU 78.710 0.993548 0.343681 gudD - Glucarate dehydratase - Pseudomonas putida - gudD gene Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D-glucarate (5-kdGluc). Indicus|evm.model.PRDE01000071.1.1 P42206 GUDD_PSEPU 79.355 0.993548 0.343681 gudD - Glucarate dehydratase - Pseudomonas putida - gudD gene Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D-glucarate (5-kdGluc). Indicus|evm.model.PRDE01000082.1.1 Q604U6 SMC_METCA 54.318 0.729124 0.420017 smc - Chromosome partition protein Smc - Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) - smc gene Required for chromosome condensation and partitioning. Indicus|evm.model.PRDE01000082.1.2 A4VKM9 ZIPA_PSEU5 92.058 0.992806 1.01832 zipA - Cell division protein ZipA - Pseudomonas stutzeri (strain A1501) - zipA gene Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Indicus|evm.model.PRDE01000083.1.1 A4VRG3 Y3941_PSEU5 96.078 0.980583 0.539267 PST_3941 - UPF0312 protein PST_3941 precursor - Pseudomonas stutzeri (strain A1501) - PST_3941 gene Indicus|evm.model.PRDE01000083.1.2 P52477 MEXA_PSEAE 69.653 0.907895 0.992167 mexA - Multidrug resistance protein MexA precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - mexA gene The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine. Indicus|evm.model.PRDE01000083.1.3 Q88N31 TTGB_PSEPK 83.750 0.995833 0.228571 ttgB - Probable efflux pump membrane transporter TtgB - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - ttgB gene Probable membrane transporter component of the TtgABC efflux pump with unknown specificity. Indicus|evm.model.PRDE01000091.1.2 A4VIU7 ASSY_PSEU5 100.000 0.995074 1.00247 argG - Argininosuccinate synthase - Pseudomonas stutzeri (strain A1501) - argG gene Indicus|evm.model.PRDE01000091.1.3 Q55595 LGUL_SYNY3 67.717 0.961832 1 gloA - Probable lactoylglutathione lyase - Synechocystis sp. (strain PCC 6803 / Kazusa) - gloA gene Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Indicus|evm.model.PRDE01000091.1.4 Q02QY3 RNFE_PSEAB 75.532 0.428571 1.82353 rnfE - Ion-translocating oxidoreductase complex subunit E - Pseudomonas aeruginosa (strain UCBPP-PA14) - rnfE gene Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Indicus|evm.model.PRDE01000091.1.5 A4XS49 RNFG_PSEMY 76.531 0.783133 1.18009 rnfG - Ion-translocating oxidoreductase complex subunit G - Pseudomonas mendocina (strain ymp) - rnfG gene Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Indicus|evm.model.PRDE01000091.1.6 A4XS50 RNFD_PSEMY 83.090 0.994169 1 rnfD - Ion-translocating oxidoreductase complex subunit D - Pseudomonas mendocina (strain ymp) - rnfD gene Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Indicus|evm.model.PRDE01000091.1.7 Q9HYB8 RNFC_PSEAE 68.421 0.694444 0.139535 rnfC - Ion-translocating oxidoreductase complex subunit C - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - rnfC gene Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Indicus|evm.model.PRDE01000105.1.1 Q9HYF1 PK22_PSEAE 80.645 0.938462 0.131048 PA3455 - Polyphosphate:AMP phosphotransferase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA3455 gene Uses inorganic polyphosphate (polyP) as a donor to convert AMP to ADP. Can also convert GMP to GDP, with lower efficiency. Cannot dephosphorylate ADP in the presence of polyP. Indicus|evm.model.PRDE01000106.1.1 Q9HVC8 PRMC_PSEAE 70.896 0.39233 1.22826 prmC - Release factor glutamine methyltransferase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - prmC gene Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. Indicus|evm.model.PRDE01000110.1.1 Q9HYF1 PK22_PSEAE 70.516 0.997543 0.820565 PA3455 - Polyphosphate:AMP phosphotransferase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA3455 gene Uses inorganic polyphosphate (polyP) as a donor to convert AMP to ADP. Can also convert GMP to GDP, with lower efficiency. Cannot dephosphorylate ADP in the presence of polyP. Indicus|evm.model.PRDE01000110.1.5 Q56623 GALE_VIBCL 51.812 0.535714 1.53659 galE - UDP-glucose 4-epimerase - Vibrio cholerae - galE gene Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity). Indicus|evm.model.PRDE01000110.1.6 A4SRG6 CYSC_AERS4 64.800 0.925373 0.683673 cysC - Adenylyl-sulfate kinase - Aeromonas salmonicida (strain A449) - cysC gene Catalyzes the synthesis of activated sulfate. Indicus|evm.model.PRDE01000110.1.7 P31742 GSPE_XANCP 52.882 0.707052 0.975309 xpsE - Type II secretion system protein E - Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) - xpsE gene ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm. Indicus|evm.model.PRDE01000110.1.10 Q07698 ABCA_AERSA 49.026 0.671772 1.48377 abcA - ABC transporter protein AbcA - Aeromonas salmonicida - abcA gene Influences the expression of the surface array protein gene (vapA). May have both regulatory and transport activities. Indicus|evm.model.PRDE01000110.1.11 P37779 RMLA1_SHIFL 74.016 0.615572 1.40753 rfbA - Glucose-1-phosphate thymidylyltransferase 1 - Shigella flexneri - rfbA gene Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Indicus|evm.model.PRDE01000110.1.12 P26392 RMLD_SALTY 50.769 0.874576 0.986622 rfbD - dTDP-4-dehydrorhamnose reductase - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - rfbD gene Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS). Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well. Indicus|evm.model.PRDE01000110.1.13 P0C7J0 RMLB_XANCP 64.286 0.551895 1.72934 rfbB - dTDP-glucose 4,6-dehydratase - Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) - rfbB gene Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. Indicus|evm.model.PRDE01000110.1.15 A4VMF7 IHFB_PSEU5 96.774 0.968421 1.02151 ihfB - Integration host factor subunit beta - Pseudomonas stutzeri (strain A1501) - ihfB gene This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Indicus|evm.model.PRDE01000110.1.16 P9WH05 DEAD_MYCTU 47.645 0.980251 0.989343 deaD - ATP-dependent RNA helicase DeaD - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - deaD gene DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. Indicus|evm.model.PRDE01000126.1.1 P76403 TRHP_ECOLI 64.912 0.949153 0.130243 trhP - tRNA hydroxylation protein P - Escherichia coli (strain K12) - trhP gene Involved in prephenate-dependent formation of 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis (PubMed:31253794). Involved differently in ho5U formation in each tRNA; tRNA(Leu3) and tRNA(Pro3) are major targets of TrhP (PubMed:31253794). Indicus|evm.model.PRDE01000127.1.1 P0AG05 S3AD_ECOLX 57.303 0.792793 0.422053 aadA - Aminoglycoside (3'') (9) adenylyltransferase - Escherichia coli - aadA gene Mediates bacterial resistance to the antibiotics streptomycin and spectinomycin. Indicus|evm.model.PRDE01000127.1.5 Q8X4Z7 RUTR_ECO57 55.349 0.740484 1.36321 rutR - HTH-type transcriptional regulator RutR - Escherichia coli O157:H7 - rutR gene Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX) (By similarity). Indicus|evm.model.PRDE01000149.1.1 A2VE54 UN93A_BOVIN 100.000 0.685393 0.194748 UNC93A - Protein unc-93 homolog A - Bos taurus (Bovine) - UNC93A gene Indicus|evm.model.PRDE01000169.1.1 P59571 COPA_PSESM 71.357 0.988294 1.01528 copA - Copper resistance protein A homolog precursor - Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) - copA gene Could be involved in copper resistance. May have oxidase activity (By similarity). Indicus|evm.model.PRDE01000169.1.3 P59572 COPB_PSESM 61.811 0.49901 1.71769 copB - Copper resistance protein B homolog precursor - Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) - copB gene Exact function not known. Could be involved in copper resistance (By similarity). Indicus|evm.model.PRDE01000169.1.10 A1U5D9 NQOR_MARHV 79.121 0.989071 0.919598 Maqu_3134 - NAD(P)H dehydrogenase (quinone) - Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8) - Maqu_3134 gene Indicus|evm.model.PRDE01000169.1.11 Q9I4C8 Y1210_PSEAE 70.435 0.982833 1.00431 PA1210 - Putative quercetin 2,3-dioxygenase PA1210 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA1210 gene Putative quercetin 2,3-dioxygenase. Indicus|evm.model.PRDE01000174.1.1 Q44006 CZCR_CUPMC 78.667 0.91358 0.36 czcR - Transcriptional activator protein CzcR - Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) - czcR gene Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Indicus|evm.model.PRDE01000175.1.1 P45127 ETTA_HAEIN 71.277 0.978947 0.170863 ettA - Energy-dependent translational throttle protein EttA - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - ettA gene A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase. Indicus|evm.model.PRDE01000175.1.2 P35164 RESE_BACSU 37.778 0.134036 1.12733 resE - Sensor histidine kinase ResE - Bacillus subtilis (strain 168) - resE gene Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD. Indicus|evm.model.PRDE01000175.1.4 Q02UQ8 Y213_PSEAB 73.404 0.27193 2.71429 PA14_02130 - Uncharacterized protein PA14_02130 - Pseudomonas aeruginosa (strain UCBPP-PA14) - PA14_02130 gene Indicus|evm.model.PRDE01000181.1.1 A4VRZ0 MDCB_PSEU5 88.333 0.97541 0.42069 mdcB - Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase - Pseudomonas stutzeri (strain A1501) - mdcB gene Involved in the formation of 2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase. Indicus|evm.model.PRDE01000188.1.1 P42435 NASD_BACSU 54.198 0.984185 1.02112 nasD - Nitrite reductase [NAD(P)H] - Bacillus subtilis (strain 168) - nasD gene Required for nitrite assimilation. Indicus|evm.model.PRDE01000203.1.1 A4VFL7 AGUA_PSEU5 95.135 0.989247 0.505435 aguA - Agmatine deiminase - Pseudomonas stutzeri (strain A1501) - aguA gene Mediates the hydrolysis of agmatine into N-carbamoylputrescine in the arginine decarboxylase (ADC) pathway of putrescine biosynthesis, a basic polyamine. Indicus|evm.model.PRDE01000211.1.1 Q4R7F0 RBMX_MACFA 80.556 0.986111 0.184143 RBMX - RNA-binding motif protein, X chromosome - Macaca fascicularis (Crab-eating macaque) - RBMX gene RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment (By similarity). Indicus|evm.model.PRDE01000245.1.1 A4VR47 HLDE_PSEU5 95.146 0.993548 0.655391 hldE - Bifunctional protein HldE - Pseudomonas stutzeri (strain A1501) - hldE gene Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate. Indicus|evm.model.PRDE01000279.1.1 Q9I6Z0 OXODE_PSEAE 79.599 0.993333 0.668151 PA0142 - 8-oxoguanine deaminase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA0142 gene Specifically deaminates 8-Oxoguanine (8-oxoG) to uric acid. 8-oxoG is formed via the oxidation of guanine within DNA by reactive oxygen species and leads, if uncorrected, to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions. Indicus|evm.model.PRDE01000279.1.4 P76641 GUAD_ECOLI 54.608 0.955556 1.02506 guaD - Guanine deaminase - Escherichia coli (strain K12) - guaD gene Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Indicus|evm.model.PRDE01000293.1.1 Q4N0J4 ASNA_THEPA 92.500 0.995652 0.637119 TP03_0142 - ATPase ASNA1 homolog - Theileria parva (East coast fever infection agent) - TP03_0142 gene ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. Indicus|evm.model.PRDE01000295.1.1 Q06126 TNPA_BORPP 54.912 0.972569 0.987685 tnpA - Transposase for insertion sequence element IS1001 - Bordetella parapertussis - tnpA gene Involved in the transposition of the insertion sequence. Indicus|evm.model.PRDE01000308.1.1 Q92626 PXDN_HUMAN 77.470 0.958015 0.177147 PXDN - Peroxidasin homolog precursor - Homo sapiens (Human) - PXDN gene Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. Indicus|evm.model.PRDE01000315.1.1 C1DLI3 RIBA_AZOVD 80.357 0.965217 0.552885 ribA - GTP cyclohydrolase-2 - Azotobacter vinelandii (strain DJ / ATCC BAA-1303) - ribA gene Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. Indicus|evm.model.PRDE01000315.1.5 Q9HWB8 SBCC_PSEAE 84.242 0.959064 0.141206 sbcC - Nuclease SbcCD subunit C - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - sbcC gene SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity). Indicus|evm.model.PRDE01000318.1.1 Q80WQ9 ZBED4_MOUSE 70.833 0.297468 0.135274 Zbed4 - Zinc finger BED domain-containing protein 4 - Mus musculus (Mouse) - Zbed4 gene Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (PubMed:22693546). Indicus|evm.model.PRDE01000329.1.4 C0SP91 YYCJ_BACSU 55.344 0.973881 1.01515 yycJ - Putative metallo-hydrolase YycJ - Bacillus subtilis (strain 168) - yycJ gene Indicus|evm.model.PRDE01000329.1.5 Q9Z4H7 HTRA_LACHE 55.917 0.821078 0.987893 htrA - Serine protease Do-like HtrA - Lactobacillus helveticus - htrA gene Degrades abnormal exported proteins and responsible for the propeptide processing of a natural pro-protein and for the maturation of a native protein. It also plays a prominent role in stress (heat shock, ethanol, puromycin and NaCl) resistance during active exponential growth (By similarity). Indicus|evm.model.PRDE01000329.1.6 P39131 MNAA_BACSU 61.562 0.978528 0.857895 mnaA - UDP-N-acetylglucosamine 2-epimerase - Bacillus subtilis (strain 168) - mnaA gene Catalyzes the conversion of UDP-N-acetylglucosamine into UDP-N-acetylmannosamine, a precursor of the teichoic acid linkage unit. Indicus|evm.model.PRDE01000329.1.7 O34961 YJMB_BACSU 47.564 0.44456 2.1024 yjmB - Uncharacterized symporter YjmB - Bacillus subtilis (strain 168) - yjmB gene integral component of plasma membrane, organic substance transport Indicus|evm.model.PRDE01000329.1.8 Q38ZF1 UXAC_LACSS 71.685 0.252703 3.73036 uxaC - Uronate isomerase - Lactobacillus sakei subsp. sakei (strain 23K) - uxaC gene Indicus|evm.model.PRDE01000329.1.10 P54448 YQEC_BACSU 56.747 0.993103 0.976431 yqeC - Putative 6-phosphogluconate dehydrogenase YqeC - Bacillus subtilis (strain 168) - yqeC gene May act as NAD-dependent 6-P-gluconate dehydrogenase. Indicus|evm.model.PRDE01000329.1.16 P21873 ODPA_GEOSE 57.227 0.943978 0.96748 pdhA - Pyruvate dehydrogenase E1 component subunit alpha - Geobacillus stearothermophilus - pdhA gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). Indicus|evm.model.PRDE01000329.1.17 P21874 ODPB_GEOSE 65.106 0.987342 0.729231 pdhB - Pyruvate dehydrogenase E1 component subunit beta - Geobacillus stearothermophilus - pdhB gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). Indicus|evm.model.PRDE01000329.1.18 P65636 ODP2_STAAN 50.000 0.119545 1.22558 pdhC - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex - Staphylococcus aureus (strain N315) - pdhC gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). Indicus|evm.model.PRDE01000329.1.19 P11959 DLDH1_GEOSE 56.624 0.995736 0.997872 pdhD - Dihydrolipoyl dehydrogenase - Geobacillus stearothermophilus - pdhD gene Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. Indicus|evm.model.PRDE01000329.1.30 O52733 XYLT_LACBR 73.264 0.578629 1.08534 xylT - D-xylose transporter - Lactobacillus brevis - xylT gene Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Transport is driven by the proton motive force generated by either malolactic fermentation or by the metabolism of D-glucose. Indicus|evm.model.PRDE01000329.1.32 Q03HN1 XYLA_PEDPA 93.418 0.994949 0.885906 xylA - Xylose isomerase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - xylA gene Indicus|evm.model.PRDE01000329.1.33 P35850 XYLB_LACBR 67.269 0.99004 1 xylB - Xylulose kinase - Lactobacillus brevis - xylB gene Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate. Indicus|evm.model.PRDE01000329.1.35 P94489 XYNB_BACSU 47.753 0.866776 1.14071 xynB - Beta-xylosidase - Bacillus subtilis (strain 168) - xynB gene Indicus|evm.model.PRDE01000329.1.37 Q48841 PEPD_LACSK 56.763 0.995575 0.955603 Probable dipeptidase - Lactobacillus sakei Indicus|evm.model.PRDE01000329.1.39 O06980 YVCR_BACSU 53.659 0.322785 2.44015 yvcR - Uncharacterized ABC transporter ATP-binding protein YvcR - Bacillus subtilis (strain 168) - yvcR gene plasma membrane, transmembrane transporter activity, transmembrane transport Indicus|evm.model.PRDE01000329.1.40 P48636 LOGH_PSEAE 49.091 0.879032 0.635897 PA4923 - Cytokinin riboside 5'-monophosphate phosphoribohydrolase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA4923 gene Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis (Probable). Exhibits phosphoribohydrolase activity against AMP in vitro (PubMed:29901273). Indicus|evm.model.PRDE01000329.1.45 O34723 DESR_BACSU 50.000 0.989529 0.959799 desR - Transcriptional regulatory protein DesR - Bacillus subtilis (strain 168) - desR gene Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Indicus|evm.model.PRDE01000329.1.46 Q88SY9 Y3226_LACPL 63.539 0.936864 1.02079 lp_3226 - Uncharacterized RNA methyltransferase lp_3226 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - lp_3226 gene Indicus|evm.model.PRDE01000329.1.48 B5Y231 RIHC_KLEP3 48.339 0.688946 1.27961 rihC - Non-specific ribonucleoside hydrolase RihC - Klebsiella pneumoniae (strain 342) - rihC gene Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity. Indicus|evm.model.PRDE01000329.1.50 Q03DH7 RSMG_PEDPA 80.000 0.987179 0.641975 rsmG - Ribosomal RNA small subunit methyltransferase G - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rsmG gene Specifically methylates the N7 position of a guanine in 16S rRNA. Indicus|evm.model.PRDE01000329.1.51 P26497 SP0J_BACSU 49.612 0.969811 0.939716 spo0J - Stage 0 sporulation protein J - Bacillus subtilis (strain 168) - spo0J gene Required for the initiation of sporulation and for normal chromosome segregation. Antagonizes sporulation inhibition by Soj. It probably interacts with a specific DNA site and other proteins involved in partitioning and cell division, and antagonizes Soj in response to cell cycle events related to chromosome partitioning. Indicus|evm.model.PRDE01000329.1.52 P37518 YCHF_BACSU 64.602 0.991202 0.931694 ychF - Ribosome-binding ATPase YchF - Bacillus subtilis (strain 168) - ychF gene ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. Indicus|evm.model.PRDE01000329.1.54 P0DB89 IMDH_STRPQ 78.417 0.727034 0.772819 guaB - Inosine-5'-monophosphate dehydrogenase - Streptococcus pyogenes serotype M3 (strain SSI-1) - guaB gene Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Indicus|evm.model.PRDE01000329.1.59 Q88VW2 ENO2_LACPL 83.417 0.970588 0.475524 eno2 - Enolase 2 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - eno2 gene Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. Indicus|evm.model.PRDE01000329.1.60 Q88VW2 ENO2_LACPL 80.383 0.990476 0.48951 eno2 - Enolase 2 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - eno2 gene Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. Indicus|evm.model.PRDE01000329.1.61 Q38Z74 GPMA2_LACSS 85.590 0.991304 1.00437 gpmA2 - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2 - Lactobacillus sakei subsp. sakei (strain 23K) - gpmA2 gene Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Indicus|evm.model.PRDE01000329.1.69 Q03DK0 MNTH_PEDPA 92.405 0.483871 1.45638 mntH - Divalent metal cation transporter MntH - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - mntH gene H(+)-stimulated, divalent metal cation uptake system. Indicus|evm.model.PRDE01000329.1.70 P83534 RBSKI_LACSD 49.281 0.978723 0.522222 rbsK/rbiA - Bifunctional ribokinase/ribose-5-phosphate isomerase A - Lactobacillus sanfranciscensis (strain ATCC 27651 / DSM 20451 / JCM 5668 / KCTC 3205 / NCIMB 702811 / NRRL B-3934 / L-12) - rbsK/rbiA gene Bifunctional enzyme that catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium, and the reversible conversion of ribose 5-phosphate to ribulose 5-phosphate. Indicus|evm.model.PRDE01000329.1.71 B5XRB0 FRD_KLEP3 46.645 0.853591 0.391351 KPK_2907 - NADH:fumarate oxidoreductase - Klebsiella pneumoniae (strain 342) - KPK_2907 gene Catalyzes the anaerobic reduction of fumarate to succinate (PubMed:24361839, PubMed:33107907). Uses NADH as the inherent electron donor in this process (PubMed:33107907). Is involved in anaerobic fumarate respiration in K.pneumoniae (PubMed:33107907). Indicus|evm.model.PRDE01000329.1.76 P37503 YYBA_BACSU 59.333 0.986755 1.00667 yybA - Uncharacterized HTH-type transcriptional regulator YybA - Bacillus subtilis (strain 168) - yybA gene Indicus|evm.model.PRDE01000329.1.77 O08450 DEF_CLOB8 53.676 0.985401 1.00735 def - Peptide deformylase - Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) - def gene Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). Indicus|evm.model.PRDE01000329.1.78 P77888 PYRF_LACPL 56.962 0.991597 1.00422 pyrF - Orotidine 5'-phosphate decarboxylase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - pyrF gene Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Indicus|evm.model.PRDE01000329.1.82 Q49ZC7 ASP23_STAS1 45.000 0.856115 0.837349 asp23 - Alkaline shock protein 23 - Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) - asp23 gene May play a key role in alkaline pH tolerance. Indicus|evm.model.PRDE01000329.1.86 Q9CIV8 DHAK_LACLA 65.615 0.993691 0.954819 dhaK - PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK - Lactococcus lactis subsp. lactis (strain IL1403) - dhaK gene Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone via a phosphoryl group transfer from DhaL-ATP. Indicus|evm.model.PRDE01000329.1.87 Q9CIV7 DHAL_LACLA 54.444 0.972067 0.932292 dhaL - PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL - Lactococcus lactis subsp. lactis (strain IL1403) - dhaL gene ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaL-ADP is converted to DhaL-ATP via a phosphoryl group transfer from DhaM and transmits it to dihydroxyacetone binds to DhaK. Indicus|evm.model.PRDE01000329.1.88 Q927E4 DHAM1_LISIN 46.552 0.235537 1.95161 dhaM-1 - PEP-dependent dihydroxyacetone kinase 1, phosphoryl donor subunit DhaM - Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) - dhaM-1 gene Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone. Indicus|evm.model.PRDE01000329.1.89 Q9CHL8 LMRA_LACLA 69.412 0.988345 0.727119 lmrA - Multidrug resistance ABC transporter ATP-binding and permease protein - Lactococcus lactis subsp. lactis (strain IL1403) - lmrA gene Efflux transporter for a variety of amphiphilic cationic compounds, including antibiotics. Indicus|evm.model.PRDE01000329.1.90 P46853 YHHX_ECOLI 49.112 0.976676 0.994203 yhhX - Uncharacterized oxidoreductase YhhX - Escherichia coli (strain K12) - yhhX gene cytosol Indicus|evm.model.PRDE01000329.1.91 Q1WTV4 PEPT_LACS1 64.878 0.980723 1.00484 pepT - Peptidase T - Lactobacillus salivarius (strain UCC118) - pepT gene Cleaves the N-terminal amino acid of tripeptides. Indicus|evm.model.PRDE01000329.1.92 Q9KHT9 OPUCA_LISMN 60.340 0.988636 0.88665 opuCA - Carnitine transport ATP-binding protein OpuCA - Listeria monocytogenes - opuCA gene Part of the ABC transporter complex OpuCABCD involved in carnitine uptake. Probably responsible for energy coupling to the transport system. Involved, with BetL and GbuABC, in osmoprotection and cryoprotection of Listeria. Indicus|evm.model.PRDE01000329.1.93 O32243 OPUCC_BACSU 53.310 0.979452 0.963696 opuCC - Glycine betaine/carnitine/choline-binding protein OpuCC precursor - Bacillus subtilis (strain 168) - opuCC gene Member of a high affinity multicomponent binding-protein-dependent transport system for glycine betaine, carnitine, and choline. Indicus|evm.model.PRDE01000329.1.98 O31716 YKPA_BACSU 60.842 0.989562 0.887037 ykpA - Uncharacterized ABC transporter ATP-binding protein YkpA - Bacillus subtilis (strain 168) - ykpA gene ATP binding Indicus|evm.model.PRDE01000329.1.99 Q5M4M4 NDK_STRT2 50.376 0.492537 1.9562 ndk - Nucleoside diphosphate kinase - Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) - ndk gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Indicus|evm.model.PRDE01000329.1.113 F9UTW9 GLPF3_LACPL 82.796 0.133034 2.7875 glpF3 - Glycerol uptake facilitator protein 3 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - glpF3 gene Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol and H(2)O(2). Is not permeable to urea and D/L-lactic acid. Indicus|evm.model.PRDE01000329.1.114 Q5XAK0 GLPO_STRP6 60.777 0.994718 0.928105 glpO - Alpha-glycerophosphate oxidase - Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) - glpO gene Indicus|evm.model.PRDE01000329.1.115 Q03DS8 GLPK_PEDPA 87.475 0.994059 1.00198 glpK - Glycerol kinase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - glpK gene Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate. Indicus|evm.model.PRDE01000329.1.117 A7N6K9 CLCA_VIBCB 43.284 0.4 0.352564 clcA - H(+)/Cl(-) exchange transporter ClcA - Vibrio campbellii (strain ATCC BAA-1116 / BB120) - clcA gene Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. Indicus|evm.model.PRDE01000329.1.118 P46336 IOLS_BACSU 48.197 0.970492 0.983871 iolS - Aldo-keto reductase IolS - Bacillus subtilis (strain 168) - iolS gene In vitro, is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose and methylglyoxal in the presence of NADPH, albeit with poor efficiency. Shows only trace activity with benzaldehyde and butyraldehyde. Is unable to oxidize myo-inositol with either NADP(+) or NAD(+) as a cosubstrate and also does not use glucose, 2-pyridine carboxyaldehyde, fructose, xylose and succinyl semialdehyde as a substrate (PubMed:12554958, PubMed:15019785). The physiological function of this enzyme is not clear (PubMed:15019785). Does not seem to be necessary for inositol catabolism (PubMed:9226270). Indicus|evm.model.PRDE01000329.1.120 Q48796 MLES_OENOE 70.764 0.987109 1.0037 mleA - Malolactic enzyme - Oenococcus oeni - mleA gene Involved in the malolactic fermentation (MLF) of wine, which results in a natural decrease in acidity and favorable changes in wine flavors. Catalyzes the decarboxylation of L-malate to L-lactate. It can also use pyruvate as substrate. Indicus|evm.model.PRDE01000329.1.121 Q71XE0 FUMC_LISMF 58.810 0.981176 0.934066 fumC - Fumarate hydratase class II - Listeria monocytogenes serotype 4b (strain F2365) - fumC gene Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate. Indicus|evm.model.PRDE01000329.1.124 P37454 EXOA_BACSU 60.317 0.972763 1.01984 exoA - Exodeoxyribonuclease - Bacillus subtilis (strain 168) - exoA gene DNA-(apurinic or apyrimidinic site) endonuclease activity, double-stranded DNA 3'-5' exodeoxyribonuclease activity, phosphodiesterase I activity, base-excision repair Indicus|evm.model.PRDE01000329.1.125 Q03DT9 DNLJ_PEDPA 83.033 0.997001 0.988148 ligA - DNA ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - ligA gene DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. Indicus|evm.model.PRDE01000329.1.126 Q88ZH4 TAGH_LACPL 72.243 0.771341 0.903581 tagH - Teichoic acids export ATP-binding protein TagH - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - tagH gene Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01000329.1.129 P13485 TAGF_BACSU 47.236 0.962687 0.538874 tagF - Teichoic acid poly(glycerol phosphate) polymerase - Bacillus subtilis (strain 168) - tagF gene Responsible for the polymerization of the main chain of the major teichoic acid by sequential transfer of glycerol phosphate units from CDP-glycerol to the disaccharide linkage unit. Synthesizes polymers of approximately 35 glycerol phosphate units in length. Indicus|evm.model.PRDE01000329.1.131 P94422 YCNB_BACSU 48.896 0.833333 0.788136 ycnB - Uncharacterized MFS-type transporter YcnB - Bacillus subtilis (strain 168) - ycnB gene membrane Indicus|evm.model.PRDE01000329.1.132 Q88VM6 DLTA_LACPL 58.918 0.394132 2.48228 dltA - D-alanine--D-alanyl carrier protein ligase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - dltA gene Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Indicus|evm.model.PRDE01000329.1.138 Q5XD45 Y533_STRP6 49.787 0.983122 0.881041 M6_Spy0533 - Putative phosphatase M6_Spy0533 - Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) - M6_Spy0533 gene Indicus|evm.model.PRDE01000329.1.139 P39651 YWFO_BACSU 51.914 0.949772 1.01155 ywfO - Uncharacterized protein YwfO - Bacillus subtilis (strain 168) - ywfO gene dGTPase activity, dGTP catabolic process Indicus|evm.model.PRDE01000329.1.140 Q03DX9 RPOE_PEDPA 84.831 0.686047 1.44944 rpoE - Probable DNA-directed RNA polymerase subunit delta - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rpoE gene Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling. Indicus|evm.model.PRDE01000329.1.141 Q88Z76 PYRG_LACPL 79.917 0.993814 0.903166 pyrG - CTP synthase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - pyrG gene Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. Indicus|evm.model.PRDE01000329.1.142 Q88Z54 MURA2_LACPL 70.732 0.991914 0.870892 murA2 - UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - murA2 gene Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Indicus|evm.model.PRDE01000329.1.143 Q03222 RHO_BACSU 67.241 0.966587 0.981265 rho - Transcription termination factor Rho - Bacillus subtilis (strain 168) - rho gene Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template. Indicus|evm.model.PRDE01000329.1.144 B4TES5 MDTG_SALHS 50.172 0.95082 0.75495 mdtG - Multidrug resistance protein MdtG - Salmonella heidelberg (strain SL476) - mdtG gene Indicus|evm.model.PRDE01000329.1.146 Q9FCV2 ALR_LACRE 98.933 0.205269 4.85867 alr - Alanine racemase - Lactobacillus reuteri - alr gene Catalyzes the interconversion of L-alanine and D-alanine. Indicus|evm.model.PRDE01000329.1.149 Q59645 LDH_PEDAC 98.658 0.993311 0.925697 ldh - L-lactate dehydrogenase - Pediococcus acidilactici - ldh gene Catalyzes the conversion of lactate to pyruvate. Indicus|evm.model.PRDE01000329.1.150 P37474 MFD_BACSU 49.913 0.966949 1.00255 mfd - Transcription-repair-coupling factor - Bacillus subtilis (strain 168) - mfd gene Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site. Indicus|evm.model.PRDE01000329.1.152 Q8YAC7 TILS_LISMO 60.452 0.360656 0.753086 tilS/hprT - Bifunctional protein TilS/HprT - Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) - tilS/hprT gene Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity). Indicus|evm.model.PRDE01000329.1.153 Q88Z31 FTSH_LACPL 74.260 0.995542 0.903356 ftsH - ATP-dependent zinc metalloprotease FtsH - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - ftsH gene Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Indicus|evm.model.PRDE01000329.1.154 Q03SZ0 HSLO_LACBA 68.729 0.989761 0.99322 hslO - 33 kDa chaperonin - Lactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947) - hslO gene Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. Indicus|evm.model.PRDE01000329.1.155 P37567 DUS1_BACSU 59.236 0.993651 0.945946 dus1 - Probable tRNA-dihydrouridine synthase 1 - Bacillus subtilis (strain 168) - dus1 gene Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Indicus|evm.model.PRDE01000329.1.156 Q03E09 SYK_PEDPA 92.449 0.995927 0.985944 lysS - Lysine--tRNA ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - lysS gene Indicus|evm.model.PRDE01000330.1.1 Q8FW84 Y3576_BRUSU 46.410 0.873874 0.721951 BRA0576 - Putative binding protein BRA0576/BS1330_II0571 precursor - Brucella suis biovar 1 (strain 1330) - BRA0576 gene Indicus|evm.model.PRDE01000330.1.2 P0AFU0 YEJB_ECOLI 65.110 0.988827 0.983516 yejB - Inner membrane ABC transporter permease protein YejB - Escherichia coli (strain K12) - yejB gene Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. Indicus|evm.model.PRDE01000330.1.3 P33915 YEJE_ECOLI 52.830 0.954545 0.322581 yejE - Inner membrane ABC transporter permease protein YejE - Escherichia coli (strain K12) - yejE gene Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. Indicus|evm.model.PRDE01000382.1.1 P40426 PBX3_HUMAN 100.000 0.90411 0.168203 PBX3 - Pre-B-cell leukemia transcription factor 3 - Homo sapiens (Human) - PBX3 gene Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Indicus|evm.model.PRDE01000402.1.1 A6ND01 JUNO_HUMAN 64.497 0.98773 0.652 IZUMO1R - Sperm-egg fusion protein Juno precursor - Homo sapiens (Human) - IZUMO1R gene Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. Indicus|evm.model.PRDE01000430.1.1 O62772 CRFR1_SHEEP 98.246 0.91129 0.298795 CRHR1 - Corticotropin-releasing factor receptor 1 precursor - Ovis aries (Sheep) - CRHR1 gene G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. Indicus|evm.model.PRDE01000444.1.2 P55257 RMLA_YEREN 69.685 0.372607 2.34948 rmlA - Glucose-1-phosphate thymidylyltransferase - Yersinia enterocolitica - rmlA gene Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Indicus|evm.model.PRDE01000444.1.3 Q9S642 RMLB_NEIMA 77.108 0.927171 1.04692 rfbB1 - dTDP-glucose 4,6-dehydratase - Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) - rfbB1 gene Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. Indicus|evm.model.PRDE01000444.1.4 P0AGH2 YHHJ_SHIFL 61.538 0.941176 0.181818 yhhJ - Inner membrane transport permease YhhJ - Shigella flexneri - yhhJ gene Indicus|evm.model.PRDE01000445.1.1 Q9HU20 DCTB_PSEAE 65.546 0.914062 0.20915 dctB - C4-dicarboxylate transport sensor protein DctB - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - dctB gene Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA (PubMed:21725012). DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals (By similarity). Indicus|evm.model.PRDE01000445.1.2 P55257 RMLA_YEREN 69.685 0.372607 2.34948 rmlA - Glucose-1-phosphate thymidylyltransferase - Yersinia enterocolitica - rmlA gene Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Indicus|evm.model.PRDE01000445.1.3 Q9S642 RMLB_NEIMA 78.012 0.927171 1.04692 rfbB1 - dTDP-glucose 4,6-dehydratase - Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) - rfbB1 gene Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. Indicus|evm.model.PRDE01000446.1.2 Q28F07 ANM1_XENTR 50.955 0.82973 1.05413 prmt1 - Protein arginine N-methyltransferase 1 - Xenopus tropicalis (Western clawed frog) - prmt1 gene Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Methylates ilf3 to regulate its DNA-binding activity. Required for neural induction, playing a key role in the control of epidermal versus neural cell fate choice (By similarity). Methylates cirbp to regulate its subcellular location. Acts transiently during metamorphosis as a transcription coactivator, enhancing thyroid hormone (T3) receptor (TR)-mediated transcription by enhancing TR binding to the T3 response element (TRE), and histone modification through recruitment of other coactivators. Indicus|evm.model.PRDE01000446.1.3 O42706 RL21B_SCHPO 52.564 0.962733 1.00625 rpl2102 - 60S ribosomal protein L21-B - Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) - rpl2102 gene cytosol, cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.PRDE01000450.1.1 Q9I3S1 BDLA_PSEAE 42.925 0.354027 1.42926 bdlA - Biofilm dispersion protein BdlA - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - bdlA gene Essential for biofilm dispersion by sensing environmental cues. May be involved in sensing and transducing signals within cells, resulting in the modulation of c-di-GMP levels, swimming motility and adhesiveness of the bacterial cell surface. Indicus|evm.model.PRDE01000455.1.1 Q3UQ28 PXDN_MOUSE 82.937 0.966527 0.324068 Pxdn - Peroxidasin homolog precursor - Mus musculus (Mouse) - Pxdn gene Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system (By similarity). Plays a role in extracellular matrix formation. Indicus|evm.model.PRDE01000478.1.1 E1BLP6 ARI5B_BOVIN 100.000 0.984848 0.056266 ARID5B - AT-rich interactive domain-containing protein 5B - Bos taurus (Bovine) - ARID5B gene Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-340, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation (By similarity). Indicus|evm.model.PRDE01000480.1.1 Q46821 UACT_ECOLI 49.576 0.928571 0.522822 uacT - Uric acid transporter UacT - Escherichia coli (strain K12) - uacT gene Proton-dependent high-capacity transporter for uric acid. Shows also a low capacity for transport of xanthine at 37 degrees Celsius but not at 25 degrees Celsius. Indicus|evm.model.PRDE01000511.1.1 Q47146 FADE_ECOLI 53.642 0.886905 0.206388 fadE - Acyl-coenzyme A dehydrogenase - Escherichia coli (strain K12) - fadE gene Catalyzes the dehydrogenation of acyl-coenzymes A (acyl-CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for E.coli to utilize dodecanoate or oleate as the sole carbon and energy source for growth. Indicus|evm.model.PRDE01000517.1.1 Q8G2M6 BEPE_BRUSU 50.746 0.901408 0.135109 bepE - Efflux pump membrane transporter BepE - Brucella suis biovar 1 (strain 1330) - bepE gene Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics. Indicus|evm.model.PRDE01000532.1.1 Q8XC28 ETK_ECO57 52.273 0.906736 0.26584 etk - Tyrosine-protein kinase etk - Escherichia coli O157:H7 - etk gene Indicus|evm.model.PRDE01000540.1.1 Q88GG4 CHER3_PSEPK 72.119 0.981685 1 cheR3 - Putative methyltransferase Cher3 - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - cheR3 gene Indicus|evm.model.PRDE01000541.1.1 Q9HUF7 RFAP_PSEAE 78.077 0.612293 1.57836 rfaP - Lipopolysaccharide core heptose(I) kinase RfaP - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - rfaP gene Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core. The phosphorylation of the lipopolysaccharide core seems to occur prior to translocation to the periplasm and attachment of O-antigen. Also has protein-tyrosine kinase activity: autophosphorylates on all Tyr residues; in vitro can phosphorylate poly(Glu,Tyr). Indicus|evm.model.PRDE01000541.1.2 P25740 RFAG_ECOLI 48.744 0.975369 0.542781 rfaG - Lipopolysaccharide core biosynthesis protein RfaG - Escherichia coli (strain K12) - rfaG gene Involved in the addition of the first glucose residue to the lipopolysaccharide core. Indicus|evm.model.PRDE01000542.1.1 Q9HUF7 RFAP_PSEAE 78.077 0.612293 1.57836 rfaP - Lipopolysaccharide core heptose(I) kinase RfaP - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - rfaP gene Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core. The phosphorylation of the lipopolysaccharide core seems to occur prior to translocation to the periplasm and attachment of O-antigen. Also has protein-tyrosine kinase activity: autophosphorylates on all Tyr residues; in vitro can phosphorylate poly(Glu,Tyr). Indicus|evm.model.PRDE01000542.1.2 P25740 RFAG_ECOLI 48.744 0.975369 0.542781 rfaG - Lipopolysaccharide core biosynthesis protein RfaG - Escherichia coli (strain K12) - rfaG gene Involved in the addition of the first glucose residue to the lipopolysaccharide core. Indicus|evm.model.PRDE01000552.1.1 A4VKC4 RIMO_PSEU5 97.917 0.989637 0.438636 rimO - Ribosomal protein S12 methylthiotransferase RimO - Pseudomonas stutzeri (strain A1501) - rimO gene Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12. Indicus|evm.model.PRDE01000552.1.2 A8GBX9 BETA_SERP5 79.931 0.979592 0.52973 betA - Oxygen-dependent choline dehydrogenase - Serratia proteamaculans (strain 568) - betA gene Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. Indicus|evm.model.PRDE01000581.1.1 Q9P2S6 ANKY1_HUMAN 72.340 0.807018 0.0605739 ANKMY1 - Ankyrin repeat and MYND domain-containing protein 1 - Homo sapiens (Human) - ANKMY1 gene Indicus|evm.model.PRDE01000587.1.1 P31961 EDD_PSEAE 83.916 0.292784 0.797697 edd - Phosphogluconate dehydratase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - edd gene Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate. Indicus|evm.model.PRDE01000588.1.1 O68282 G6PD_PSEAE 70.492 0.213523 0.574642 zwf - Glucose-6-phosphate 1-dehydrogenase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - zwf gene Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Can utilize either NADP(+) or NAD(+). Indicus|evm.model.PRDE01000588.1.2 O68283 ALKD_PSEAE 66.986 0.881356 1.07273 eda - 2-dehydro-3-deoxy-phosphogluconate aldolase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - eda gene Indicus|evm.model.PRDE01000682.1.1 Q7Z5A7 TAFA5_HUMAN 60.563 0.394286 1.32576 TAFA5 - Chemokine-like protein TAFA-5 precursor - Homo sapiens (Human) - TAFA5 gene Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity). Indicus|evm.model.PRDE01000701.1.1 O68826 BIOP_PSEAE 85.567 0.989691 0.339161 PA3474 - Probable biotin transporter - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA3474 gene Uptake of biotin. Indicus|evm.model.PRDE01000706.1.1 Q9HV32 PMRA_PSEAE 55.140 0.548969 1.75566 pmrA - Response regulator protein PmrA - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pmrA gene Member of the two-component regulatory system PmrA/PmrB that plays a role in the regulation of resistance towards polymyxin B and cationic antimicrobial peptides in response to limiting concentrations of Mg(2+) (PubMed:14507375). Functions as a transcriptional activator by direct binding to a cis-acting sequence upstream of the target gene promoters including lipase lipA and pmrH promoters (PubMed:16707691, PubMed:29379484). Autoregulates also its own pmrAB operon under Mg(2+)-limiting conditions (PubMed:14507375, PubMed:16707691). Indicus|evm.model.PRDE01000708.1.1 P20966 PTFBC_ECOLI 71.254 0.987879 0.586146 fruA - PTS system fructose-specific EIIB'BC component - Escherichia coli (strain K12) - fruA gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. Indicus|evm.model.PRDE01000721.1.1 A4VR47 HLDE_PSEU5 92.417 0.995261 0.446089 hldE - Bifunctional protein HldE - Pseudomonas stutzeri (strain A1501) - hldE gene Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate. Indicus|evm.model.PRDE01000721.1.2 Q4KJB2 MSBA_PSEF5 81.132 0.610063 1.58735 msbA - ATP-dependent lipid A-core flippase - Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) - msbA gene Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. Indicus|evm.model.PRDE01000733.1.2 Q9ZN99 CATA_DESVM 79.646 0.984716 0.954167 katA - Catalase - Desulfovibrio vulgaris (strain DSM 19637 / Miyazaki F) - katA gene Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Indicus|evm.model.PRDE01000737.1.1 A4VMX4 MNMC_PSEU5 99.091 0.996974 1.00152 mnmC - tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC - Pseudomonas stutzeri (strain A1501) - mnmC gene Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34. Indicus|evm.model.PRDE01000737.1.11 P73123 RBCR_SYNY3 47.222 0.731959 0.281159 rbcR - Probable RuBisCO transcriptional regulator - Synechocystis sp. (strain PCC 6803 / Kazusa) - rbcR gene Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression. Indicus|evm.model.PRDE01000777.1.1 P42206 GUDD_PSEPU 78.740 0.984375 0.283814 gudD - Glucarate dehydratase - Pseudomonas putida - gudD gene Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D-glucarate (5-kdGluc). Indicus|evm.model.PRDE01000783.1.1 P0AF69 TSAE_SHIFL 59.559 0.668317 1.32026 tsaE - tRNA threonylcarbamoyladenosine biosynthesis protein TsaE - Shigella flexneri - tsaE gene Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). Indicus|evm.model.PRDE01000784.1.1 A4VKE7 LEUC_PSEU5 100.000 0.935484 0.195789 leuC - 3-isopropylmalate dehydratase large subunit - Pseudomonas stutzeri (strain A1501) - leuC gene Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. Indicus|evm.model.PRDE01000784.1.2 P96194 YIBL_AZOVI 85.849 0.359589 2.02778 Uncharacterized HTH-type transcriptional regulator in ibpB-leuC intergenic region - Azotobacter vinelandii Indicus|evm.model.PRDE01000784.1.3 P96193 IBPB_AZOVI 74.306 0.725888 1.34014 ibpB - 16 kDa heat shock protein B - Azotobacter vinelandii - ibpB gene Indicus|evm.model.PRDE01000795.1.1 P43965 Y217_HAEIN 52.326 0.734513 0.642045 HI_0217 - Putative REP-associated tyrosine transposase - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_0217 gene sequence-specific DNA binding, DNA recombination Indicus|evm.model.PRDE01000795.1.2 P22608 PILB_PSEAE 81.305 0.996479 1.00353 pilB - Type IV pilus assembly ATPase PilB - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pilB gene ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers (PubMed:15659660, PubMed:28854278). Acts as a molecular motor to provide the energy that is required for biogenesis of the pilus and the extrusion of substrates generated in the cytoplasm (PubMed:8102361, PubMed:18174131). PilB ATPase activity is also essential for T4P extension while antagonist PilT ATPase activity is required for T4P retraction (By similarity). Indicus|evm.model.PRDE01000795.1.3 P22609 PILC_PSEAE 79.706 0.994135 0.911765 pilC - Type IV pilus assembly protein PilC - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pilC gene Essential inner membrane component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers. Controls both pilus assembly and disassembly and plays an important role in PilB localization to the complex and ATPase activity. Indicus|evm.model.PRDE01000821.1.1 Q8MIK9 PP14B_PIG 100.000 0.986842 0.517007 PPP1R14B - Protein phosphatase 1 regulatory subunit 14B - Sus scrofa (Pig) - PPP1R14B gene Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). Indicus|evm.model.PRDE01000834.1.2 A4VJ19 TTCA_PSEU5 99.635 0.992727 1.00365 ttcA - tRNA-cytidine(32) 2-sulfurtransferase - Pseudomonas stutzeri (strain A1501) - ttcA gene Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. Indicus|evm.model.PRDE01000858.1.1 A4VM16 IHFA_PSEU5 62.667 0.403614 1.66 ihfA - Integration host factor subunit alpha - Pseudomonas stutzeri (strain A1501) - ihfA gene This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Indicus|evm.model.PRDE01000858.1.2 Q4KEV9 SYFB_PSEF5 78.535 0.997478 1.00126 pheT - Phenylalanine--tRNA ligase beta subunit - Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) - pheT gene Indicus|evm.model.PRDE01000858.1.3 A4XTS5 SYFA_PSEMY 97.297 0.989247 0.550296 pheS - Phenylalanine--tRNA ligase alpha subunit - Pseudomonas mendocina (strain ymp) - pheS gene Indicus|evm.model.PRDE01000879.1.1 A4VKC2 BETB_PSEU5 96.443 0.992126 0.518367 betB - Betaine aldehyde dehydrogenase - Pseudomonas stutzeri (strain A1501) - betB gene Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid. Indicus|evm.model.PRDE01000886.1.1 P17331 G3P4_CAEEL 67.463 0.964706 0.997067 gpd-4 - Glyceraldehyde-3-phosphate dehydrogenase 4 - Caenorhabditis elegans - gpd-4 gene cytosol, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, glycolytic process Indicus|evm.model.PRDE01000886.1.2 P08574 CY1_HUMAN 56.633 0.565217 1.06154 CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c. Indicus|evm.model.PRDE01000893.1.1 Q9X6U2 BDHA_CUPNH 70.039 0.984436 0.996124 hbdH1 - D-beta-hydroxybutyrate dehydrogenase - Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) - hbdH1 gene Indicus|evm.model.PRDE01000893.1.2 P42314 YXJC_BACSU 57.516 0.967672 0.983051 yxjC - Uncharacterized transporter YxjC - Bacillus subtilis (strain 168) - yxjC gene integral component of plasma membrane Indicus|evm.model.PRDE01000893.1.3 P76460 ATOE_ECOLI 49.515 0.978155 0.936364 atoE - Putative short-chain fatty acid transporter - Escherichia coli (strain K12) - atoE gene May be responsible for the uptake of short-chain fatty acids. Indicus|evm.model.PRDE01000906.1.1 Q02GC2 PILY1_PSEAB 49.580 0.998544 0.593264 pilY1 - Type IV pilus biogenesis factor PilY1 precursor - Pseudomonas aeruginosa (strain UCBPP-PA14) - pilY1 gene Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili. Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity). Regulates surface-activated virulence possibly by acting as a surface-attachment mechanosensor (PubMed:25385640). Indicus|evm.model.PRDE01000907.1.2 P17825 FMAE_DICNO 50.000 0.605442 0.913043 fimA - Fimbrial protein precursor - Dichelobacter nodosus - fimA gene Indicus|evm.model.PRDE01000914.1.1 P00515 KAP2_BOVIN 98.824 0.509091 0.411471 PRKAR2A - cAMP-dependent protein kinase type II-alpha regulatory subunit - Bos taurus (Bovine) - PRKAR2A gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase (By similarity). Indicus|evm.model.PRDE01000916.1.1 Q9I6Z2 AHPF_PSEAE 86.189 0.992347 0.752399 ahpF - Alkyl hydroperoxide reductase subunit F - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - ahpF gene Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein (By similarity). Indicus|evm.model.PRDE01000932.1.1 Q9I6Z2 AHPF_PSEAE 86.900 0.995614 0.43762 ahpF - Alkyl hydroperoxide reductase subunit F - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - ahpF gene Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein (By similarity). Indicus|evm.model.PRDE01000957.1.2 A4VG93 RIMK_PSEU5 99.615 0.561822 1.53156 rimK - Probable alpha-L-glutamate ligase - Pseudomonas stutzeri (strain A1501) - rimK gene Indicus|evm.model.PRDE01000961.1.1 A9WGE3 SCCT_CHLAA 52.108 0.827068 0.992537 Caur_2266 - Succinyl-CoA--D-citramalate CoA-transferase - Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) - Caur_2266 gene Involved in the 3-hydroxypropionate cycle used for autotrophic carbon dioxide fixation, and in the glyoxylate assimilation cycle used to regenerate acetyl-CoA and produce pyruvate as universal precursor for biosynthesis. Catalyzes the transfer of CoA moiety from succinyl-CoA to D-citramalate to yield citramalyl-CoA (By similarity). Indicus|evm.model.PRDE01000973.1.1 P59046 NAL12_HUMAN 82.759 0.774775 0.104618 NLRP12 - NACHT, LRR and PYD domains-containing protein 12 - Homo sapiens (Human) - NLRP12 gene Plays an essential role as an potent mitigator of inflammation (PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (PubMed:30902577). Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity). Indicus|evm.model.PRDE01000989.1.1 Q8IYW2 CFA46_HUMAN 51.880 0.992308 0.0478821 CFAP46 - Cilia- and flagella-associated protein 46 - Homo sapiens (Human) - CFAP46 gene As part of the central apparatus of the cilium axoneme plays a role in cilium movement. Indicus|evm.model.PRDE01000998.1.1 Q2THW8 ZDHC8_CANLF 100.000 0.984615 0.0849673 ZDHHC8 - Palmitoyltransferase ZDHHC8 - Canis lupus familiaris (Dog) - ZDHHC8 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes. Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (By similarity). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (By similarity). Could also play a role in glutamatergic transmission (By similarity). Indicus|evm.model.PRDE01001018.1.1 A4VP83 CH10_PSEU5 100.000 0.979592 1.01031 groS - 10 kDa chaperonin - Pseudomonas stutzeri (strain A1501) - groS gene Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. Indicus|evm.model.PRDE01001018.1.2 A4VP82 CH60_PSEU5 99.817 0.996344 1.00183 groL - 60 kDa chaperonin - Pseudomonas stutzeri (strain A1501) - groL gene Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Indicus|evm.model.PRDE01001030.1.1 Q4R6F8 TCPB_MACFA 59.831 0.96206 0.68972 CCT2 - T-complex protein 1 subunit beta - Macaca fascicularis (Crab-eating macaque) - CCT2 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Indicus|evm.model.PRDE01001073.1.1 A0JSP6 PCKG_ARTS2 73.118 0.902439 0.335516 pckG - Phosphoenolpyruvate carboxykinase [GTP] - Arthrobacter sp. (strain FB24) - pckG gene Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Indicus|evm.model.PRDE01001125.1.1 A4VMY9 DAPE_PSEU5 98.252 0.993031 0.751309 dapE - Succinyl-diaminopimelate desuccinylase - Pseudomonas stutzeri (strain A1501) - dapE gene Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Indicus|evm.model.PRDE01001128.1.1 P45157 RECB_HAEIN 53.261 0.65 0.115607 recB - RecBCD enzyme subunit RecB - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - recB gene A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA. Indicus|evm.model.PRDE01001131.1.1 B2RY50 ODAD2_MOUSE 98.413 0.861111 0.0694311 Odad2 - Outer dynein arm-docking complex subunit 2 - Mus musculus (Mouse) - Odad2 gene Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule (By similarity). May be involved in a late step of axonemal outer dynein arm assembly (PubMed:23849778). Indicus|evm.model.PRDE01001147.1.1 P0AF55 YJCH_SHIFL 57.426 0.952381 1.00962 yjcH - Inner membrane protein YjcH - Shigella flexneri - yjcH gene Indicus|evm.model.PRDE01001157.1.1 Q9HU20 DCTB_PSEAE 62.189 0.995025 0.328431 dctB - C4-dicarboxylate transport sensor protein DctB - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - dctB gene Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA (PubMed:21725012). DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals (By similarity). Indicus|evm.model.PRDE01001215.1.1 Q9HXD6 MOAA1_PSEAE 79.574 0.991525 0.717325 moaA1 - GTP 3',8-cyclase 1 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - moaA1 gene Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. Indicus|evm.model.PRDE01001215.1.2 P0AEZ9 MOAB_ECOLI 59.394 0.901099 1.07059 moaB - Molybdenum cofactor biosynthesis protein B - Escherichia coli (strain K12) - moaB gene May be involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity. Indicus|evm.model.PRDE01001218.1.1 P45736 YCJD_ECOLI 54.717 0.83871 0.529915 ycjD - Uncharacterized protein YcjD - Escherichia coli (strain K12) - ycjD gene Indicus|evm.model.PRDE01001218.1.2 A4VI89 RF3_PSEU5 94.877 0.996212 1.0019 prfC - Peptide chain release factor 3 - Pseudomonas stutzeri (strain A1501) - prfC gene Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Indicus|evm.model.PRDE01001218.1.5 Q9HVR0 PXPA3_PSEAE 77.551 0.97992 0.992032 pxpA3 - 5-oxoprolinase subunit A 3 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pxpA3 gene Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Indicus|evm.model.PRDE01001218.1.7 A0A0H2ZH52 DPPF_PSEAB 86.149 0.472756 1.93189 dppF - Di/tripeptide transport ATP-binding protein DppF - Pseudomonas aeruginosa (strain UCBPP-PA14) - dppF gene Part of the ABC transporter DppABCDF involved in the uptake of various di/tripeptides (PubMed:25338022). Is also involved in the uptake of phaseolotoxin, a toxic tripeptide inhibiting the enzyme ornithine carbamoyltransferase (PubMed:25338022). Responsible for energy coupling to the transport system (Probable). Indicus|evm.model.PRDE01001218.1.8 A0A0H2ZFV0 DPPC_PSEAB 87.833 0.988679 0.874587 dppC - Di/tripeptide transport system permease protein DppC - Pseudomonas aeruginosa (strain UCBPP-PA14) - dppC gene Part of the ABC transporter DppABCDF involved in the uptake of various di/tripeptides (PubMed:25338022). Is also involved in the uptake of phaseolotoxin, a toxic tripeptide inhibiting the enzyme ornithine carbamoyltransferase (PubMed:25338022). Responsible for the translocation of the substrate across the membrane (Probable). Indicus|evm.model.PRDE01001218.1.9 A0A0H2ZGW7 DPPB_PSEAB 89.286 0.994065 1.00298 dppB - Di/tripeptide transport system permease protein DppB - Pseudomonas aeruginosa (strain UCBPP-PA14) - dppB gene Part of the ABC transporter DppABCDF involved in the uptake of various di/tripeptides (PubMed:25338022). Is also involved in the uptake of phaseolotoxin, a toxic tripeptide inhibiting the enzyme ornithine carbamoyltransferase (PubMed:25338022). Responsible for the translocation of the substrate across the membrane (Probable). Indicus|evm.model.PRDE01001218.1.10 A0A0H2ZGV7 DPPA4_PSEAB 76.877 0.51636 1.8349 dppA4 - Di/tripeptide-binding protein 4 precursor - Pseudomonas aeruginosa (strain UCBPP-PA14) - dppA4 gene Part of the ABC transporter DppABCDF involved in the uptake of various di/tripeptides (PubMed:25338022). Prefers dipeptides with acidic residues at the C-terminal end. Efficiently uses tripeptides (PubMed:25338022). Indicus|evm.model.PRDE01001218.1.11 A0A0H2ZGN2 DPPA3_PSEAB 81.188 0.986301 0.958724 dppA3 - Di/tripeptide-binding protein 3 precursor - Pseudomonas aeruginosa (strain UCBPP-PA14) - dppA3 gene Part of the ABC transporter DppABCDF involved in the uptake of various di/tripeptides (PubMed:25338022). Prefers dipeptides with acidic residues at the C-terminal end. Involved in the uptake of phaseolotoxin, a toxic tripeptide inhibiting the enzyme ornithine carbamoyltransferase (PubMed:25338022). Indicus|evm.model.PRDE01001218.1.14 A0A0H2ZGV2 DPPA1_PSEAB 78.439 0.676845 1.46369 dppA1 - Di/tripeptide-binding protein 1 precursor - Pseudomonas aeruginosa (strain UCBPP-PA14) - dppA1 gene Part of the ABC transporter DppABCDF involved in the uptake of various di/tripeptides (PubMed:25338022). Prefers dipeptides with acidic residues at the C-terminal end. Involved in the uptake of phaseolotoxin, a toxic tripeptide inhibiting the enzyme ornithine carbamoyltransferase (PubMed:25338022). Indicus|evm.model.PRDE01001222.1.1 Q9UPA5 BSN_HUMAN 89.268 0.993464 0.155884 BSN - Protein bassoon - Homo sapiens (Human) - BSN gene Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Indicus|evm.model.PRDE01001241.1.1 G3V928 LRP1_RAT 99.167 0.748428 0.0349835 Lrp1 - Prolow-density lipoprotein receptor-related protein 1 precursor - Rattus norvegicus (Rat) - Lrp1 gene Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (By similarity). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (By similarity). Indicus|evm.model.PRDE01001247.1.1 A4XQ17 UREF_PSEMY 77.778 0.984252 0.566964 ureF - Urease accessory protein UreF - Pseudomonas mendocina (strain ymp) - ureF gene Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. Indicus|evm.model.PRDE01001277.1.1 Q52WX2 SBK1_HUMAN 96.503 0.993007 0.337264 SBK1 - Serine/threonine-protein kinase SBK1 - Homo sapiens (Human) - SBK1 gene May be involved in signal-transduction pathways related to the control of brain development. Indicus|evm.model.PRDE01001278.1.3 Q9HWF9 BFR_PSEAE 77.124 0.974359 1.01299 bfr - Bacterioferritin - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - bfr gene Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. Indicus|evm.model.PRDE01001278.1.4 Q88E10 MCPS_PSEPK 59.937 0.996721 0.954617 mcpS - Methyl-accepting chemotaxis protein McpS - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - mcpS gene Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. McpS is a specific chemoreceptor for 6 tricarboxylic acid (TCA) cycle intermediates (succinate, fumarate, malate, oxaloacetate, citrate and isocitrate), butyrate and acetate. Malate, succinate, fumarate and oxaloacetate cause the strongest chemotactic response. Indicus|evm.model.PRDE01001278.1.5 Q9HV30 Y4778_PSEAE 80.172 0.871212 1 PA4778 - Uncharacterized HTH-type transcriptional regulator PA4778 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA4778 gene transcription regulatory region sequence-specific DNA binding, positive regulation of transcription, DNA-templated Indicus|evm.model.PRDE01001278.1.6 Q4L970 COPA_STAHJ 45.477 0.986129 0.997484 copA - Copper-exporting P-type ATPase - Staphylococcus haemolyticus (strain JCSC1435) - copA gene Involved in copper export. Indicus|evm.model.PRDE01001285.1.1 P0AAW4 YBHP_SHIFL 60.185 0.432323 1.95652 ybhP - Uncharacterized protein YbhP - Shigella flexneri - ybhP gene Indicus|evm.model.PRDE01001304.1.1 P00429 CX6B1_BOVIN 100.000 0.985507 0.802326 COX6B1 - Cytochrome c oxidase subunit 6B1 - Bos taurus (Bovine) - COX6B1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Indicus|evm.model.PRDE01001351.1.1 Q4W5P6 SIM43_HUMAN 96.774 0.983871 0.984127 SMIM43 - Small integral membrane protein 43 - Homo sapiens (Human) - SMIM43 gene Indicus|evm.model.PRDE01001358.1.1 P0A119 DNAG_PSEPU 70.899 0.99723 0.54697 dnaG - DNA primase - Pseudomonas putida - dnaG gene RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Indicus|evm.model.PRDE01001368.1.4 Q7NSJ4 GCSH_CHRVO 50.000 0.63964 0.867188 gcvH - Glycine cleavage system H protein - Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) - gcvH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. Indicus|evm.model.PRDE01001370.1.1 Q92626 PXDN_HUMAN 96.703 0.725806 0.0838404 PXDN - Peroxidasin homolog precursor - Homo sapiens (Human) - PXDN gene Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. Indicus|evm.model.PRDE01001381.1.1 Q9Y5J5 PHLA3_HUMAN 93.443 0.975806 0.976378 PHLDA3 - Pleckstrin homology-like domain family A member 3 - Homo sapiens (Human) - PHLDA3 gene p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. Indicus|evm.model.PRDE01001414.1.1 P0AGN2 XANP_SHIFL 47.647 0.861183 0.840173 xanP - Xanthine permease XanP - Shigella flexneri - xanP gene Specific, proton motive force-dependent high-affinity transporter for xanthine. Indicus|evm.model.PRDE01001428.1.1 O00555 CAC1A_HUMAN 95.238 0.630435 0.0917797 CACNA1A - Voltage-dependent P/Q-type calcium channel subunit alpha-1A - Homo sapiens (Human) - CACNA1A gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). Indicus|evm.model.PRDE01001436.1.2 P37626 YHII_ECOLI 46.667 0.959677 0.349296 yhiI - Uncharacterized protein YhiI precursor - Escherichia coli (strain K12) - yhiI gene plasma membrane Indicus|evm.model.PRDE01001440.1.1 P27302 TKT1_ECOLI 72.727 0.997881 0.711916 tktA - Transketolase 1 - Escherichia coli (strain K12) - tktA gene Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Thus, catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Indicus|evm.model.PRDE01001506.1.4 Q9I6M5 DAVD_PSEAE 74.074 0.99182 1.01242 davD - Glutarate-semialdehyde dehydrogenase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - davD gene Catalyzes the conversion of 5-oxopentanoate (glutarate semialdehyde) to glutarate. Involved in L-lysine degradation. Indicus|evm.model.PRDE01001506.1.5 Q88RB9 DAVT_PSEPK 83.059 0.992974 1.00471 davT - 5-aminovalerate aminotransferase DavT - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - davT gene Catalyzes the conversion of 5-aminovalerate to 5-oxopentanoate. Indicus|evm.model.PRDE01001506.1.6 P45455 RPE_SERMA 77.990 0.924444 1.07143 rpe - Ribulose-phosphate 3-epimerase - Serratia marcescens - rpe gene Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. Indicus|evm.model.PRDE01001506.1.7 Q88QS2 GPH_PSEPK 74.000 0.980198 0.371324 PP_0416 - Phosphoglycolate phosphatase - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - PP_0416 gene Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Indicus|evm.model.PRDE01001513.1.1 A4K436 RTEL1_BOVIN 99.138 0.946721 0.200658 RTEL1 - Regulator of telomere elongation helicase 1 - Bos taurus (Bovine) - RTEL1 gene ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. Indicus|evm.model.PRDE01001519.1.1 P27175 DHG_GLUOX 47.610 0.995876 0.600248 gdh - Quinoprotein glucose dehydrogenase precursor - Gluconobacter oxydans (strain 621H) - gdh gene Indicus|evm.model.PRDE01001524.1.1 P0AES2 GUDD_ECOLI 60.440 0.849057 0.237668 gudD - Glucarate dehydratase - Escherichia coli (strain K12) - gudD gene Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate. Indicus|evm.model.PRDE01001524.1.2 Q3KI36 KDGD_PSEPF 88.119 0.993421 1.0033 Pfl01_0827 - Probable 5-dehydro-4-deoxyglucarate dehydratase - Pseudomonas fluorescens (strain Pf0-1) - Pfl01_0827 gene Indicus|evm.model.PRDE01001524.1.3 P42236 KGSDH_BACSU 47.808 0.981289 0.985656 gucD - Alpha-ketoglutaric semialdehyde dehydrogenase - Bacillus subtilis (strain 168) - gucD gene Catalyzes the NAD(P)(+)-dependent oxidation of alpha-ketoglutaric semialdehyde (alphaKGSA) to alpha-ketoglutarate. Prefers NADP(+) to NAD(+) as a cosubstrate. In vitro, can also use various aldehydes. Indicus|evm.model.PRDE01001537.1.1 Q6VAY5 DNAJ_PSEST 100.000 0.992908 0.375 dnaJ - Chaperone protein DnaJ - Pseudomonas stutzeri - dnaJ gene Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins. Indicus|evm.model.PRDE01001551.1.1 P96556 TRPE_ARTGO 69.474 0.959391 0.370998 trpE - Anthranilate synthase component 1 - Arthrobacter globiformis - trpE gene Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity). Indicus|evm.model.PRDE01001562.1.1 M0QZC1 RN225_HUMAN 49.462 0.93617 0.285714 RNF225 - RING finger protein 225 - Homo sapiens (Human) - RNF225 gene Indicus|evm.model.PRDE01001612.1.1 A4VPA3 SECA_PSEU5 97.414 0.997126 0.381161 secA - Protein translocase subunit SecA - Pseudomonas stutzeri (strain A1501) - secA gene Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Indicus|evm.model.PRDE01001668.1.1 P62246 RS15A_RAT 76.154 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Indicus|evm.model.PRDE01001676.1.1 A6NCL2 LRCL1_HUMAN 62.602 0.976 0.786164 LRCOL1 - Leucine-rich colipase-like protein 1 precursor - Homo sapiens (Human) - LRCOL1 gene response to food Indicus|evm.model.PRDE01001762.1.1 Q9I5W9 Y567_PSEAE 90.385 0.586207 1.67308 PA0567 - UPF0057 membrane protein PA0567 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA0567 gene Indicus|evm.model.PRDE01001779.1.1 Q04871 YCL2_ECO11 55.063 0.308718 2.91916 Uncharacterized 37.6 kDa protein in cld 5'region - Escherichia coli O111:H- Indicus|evm.model.PRDE01001779.1.2 O33952 UDG8_ECOLX 72.280 0.779352 1.2732 ugd - UDP-glucose 6-dehydrogenase - Escherichia coli - ugd gene Indicus|evm.model.PRDE01001795.1.1 Q9UHF1 EGFL7_HUMAN 90.164 0.674157 0.326007 EGFL7 - Epidermal growth factor-like protein 7 precursor - Homo sapiens (Human) - EGFL7 gene Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. Indicus|evm.model.PRDE01001808.1.1 P04114 APOB_HUMAN 88.571 0.958333 0.0157791 APOB - Apolipoprotein B-100 precursor - Homo sapiens (Human) - APOB gene Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Indicus|evm.model.PRDE01001827.1.1 P24577 YI71_BURM1 54.098 0.686047 0.310469 Bmul_4719 - Insertion element IS407 uncharacterized 31.7 kDa protein - Burkholderia multivorans (strain ATCC 17616 / 249) - Bmul_4719 gene Indicus|evm.model.PRDE01001827.1.2 P17984 YIA2_RHISP 90.244 0.366972 0.677019 Insertion element ISR1 uncharacterized 17 kDa protein A2 - Rhizobium sp. Indicus|evm.model.PRDE01001861.1.3 P72227 PNCC_PSEPU 74.026 0.921687 1.0375 pncC - Nicotinamide-nucleotide amidohydrolase PncC - Pseudomonas putida - pncC gene Has NMN aminohydrolase activity, not active on other substrates. Indicus|evm.model.PRDE01001862.1.1 Q9HZX3 TGPA_PSEAE 65.471 0.995516 0.333832 tgpA - Protein-glutamine gamma-glutamyltransferase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - tgpA gene Displays transglutaminase activity (TGase) in vitro. Plays a critical role in the viability of P.aeruginosa. Might contribute to an essential function linked to the cell wall. Indicus|evm.model.PRDE01001895.1.1 P07293 CAC1S_RABIT 91.176 0.697917 0.0512547 CACNA1S - Voltage-dependent L-type calcium channel subunit alpha-1S - Oryctolagus cuniculus (Rabbit) - CACNA1S gene Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle (PubMed:9465115, PubMed:15201141, PubMed:25548159, PubMed:27621462, PubMed:29078335, PubMed:29467163). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction (PubMed:9465115 PubMed:15201141, PubMed:27621462). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. Indicus|evm.model.PRDE01001898.1.1 Q13ZK7 SSUB1_PARXL 52.083 0.269122 1.03824 ssuB1 - Aliphatic sulfonates import ATP-binding protein SsuB 1 - Paraburkholderia xenovorans (strain LB400) - ssuB1 gene Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01001912.1.3 Q9HX02 EUTC_PSEAE 77.863 0.962687 0.490842 eutC - Ethanolamine ammonia-lyase small subunit - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - eutC gene Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12. Indicus|evm.model.PRDE01001922.1.1 Q00839 HNRPU_HUMAN 96.923 0.994872 0.236364 HNRNPU - Heterogeneous nuclear ribonucleoprotein U - Homo sapiens (Human) - HNRNPU gene DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:8174554, PubMed:28622508). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:8174554, PubMed:9353307, PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Contributes also to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:7509195, PubMed:1324173, PubMed:9204873, PubMed:9405365, PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:28622508). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). Indicus|evm.model.PRDE01001927.1.1 Q9HZP7 ETFA_PSEAE 88.026 0.993548 1.00324 etfA - Electron transfer flavoprotein subunit alpha - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - etfA gene The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Indicus|evm.model.PRDE01001927.1.2 P24202 MRR_ECOLI 68.421 0.980583 1.01645 mrr - Mrr restriction system protein - Escherichia coli (strain K12) - mrr gene Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA. Indicus|evm.model.PRDE01001927.1.4 P07989 T1M_SALPO 58.380 0.546638 1.74291 hsdM - Type I restriction enzyme StySPI M protein - Salmonella potsdam - hsdM gene Methylation of specific adenine residues; required for both restriction and modification activities. Indicus|evm.model.PRDE01001936.1.1 C1DIY8 COWN_AZOVD 61.458 0.959596 1.02062 cowN - N(2)-fixation sustaining protein CowN - Azotobacter vinelandii (strain DJ / ATCC BAA-1303) - cowN gene Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO. Indicus|evm.model.PRDE01001936.1.3 P52326 RPOD_PSEPH 100.000 0.977011 0.141463 rpoD - RNA polymerase sigma factor RpoD - Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CHA0) - rpoD gene Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Indicus|evm.model.PRDE01001965.1.1 P0ABC7 HFLK_ECOLI 48.117 0.476 1.19332 hflK - Modulator of FtsH protease HflK - Escherichia coli (strain K12) - hflK gene HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins. Indicus|evm.model.PRDE01001978.1.1 Q14209 E2F2_HUMAN 83.333 0.838384 0.226545 E2F2 - Transcription factor E2F2 - Homo sapiens (Human) - E2F2 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Indicus|evm.model.PRDE01002039.1.1 F1CMY8 KSHA5_RHORH 60.241 0.961089 0.658974 kshA - 3-ketosteroid-9-alpha-monooxygenase, oxygenase component - Rhodococcus rhodochrous - kshA gene Probably involved in the degradation of cholesterol (PubMed:21642460). In vitro, catalyzes the introduction of a 9alpha-hydroxyl moiety into the ring B of 3-ketosteroid substrates such as 1,4-androstadiene-3,17-dione (ADD), 4-androstene-3,17-dione (AD), 4-androstene-17beta-ol-3-one (testosterone), 4-pregnene-3,20-dione (progesterone), 19-nor-4-androstene-3,17-dione, 1-(5alpha)-androstene-3,17-dione, 5alpha-androstane-3,17-dione, 5beta-androstane-3,17-dione, 5alpha-androstane-17beta-ol-3-one (stanolon), 11beta-hydrocortisone, 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4-BNC), 23,24-bisnorcholesta-4-ene-22-oate, 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oate (1,4-BNC) and 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA) (PubMed:21642460, PubMed:25049233). KshA5 has the broadest substrate range without a clear substrate preference and is active with Delta-4, Delta-1,4, 5alpha-H and 5beta-H steroids, as well as with steroids having bulky aliphatic side chains and an isopropionyl side chain at C17. Indicus|evm.model.PRDE01002054.1.1 P70289 PTPRV_MOUSE 58.621 0.993103 0.085044 Ptprv - Receptor-type tyrosine-protein phosphatase V precursor - Mus musculus (Mouse) - Ptprv gene May play a role in the maintenance of pluripotency. Down-regulated during differentiation. Indicus|evm.model.PRDE01002063.1.1 Q8VDJ3 VIGLN_MOUSE 47.761 0.858065 0.12224 Hdlbp - Vigilin - Mus musculus (Mouse) - Hdlbp gene Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity). Indicus|evm.model.PRDE01002084.1.1 P39693 RECJ_DICD3 57.071 0.985 0.347222 recJ - Single-stranded-DNA-specific exonuclease RecJ - Dickeya dadantii (strain 3937) - recJ gene Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available (By similarity). Indicus|evm.model.PRDE01002095.1.1 Q54EH2 RPAB1_DICDI 64.706 0.778523 0.756345 polr2e - DNA-directed RNA polymerases I, II, and III subunit rpabc1 - Dictyostelium discoideum (Slime mold) - polr2e gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity). Indicus|evm.model.PRDE01002100.1.1 Q937N7 PRPF_CUPNE 77.285 0.994778 0.967172 2-methyl-aconitate isomerase - Cupriavidus necator (Alcaligenes eutrophus) Indicus|evm.model.PRDE01002100.1.2 Q937N8 ACNA_CUPNE 78.723 0.965517 0.166858 acnM - Aconitate hydratase A - Cupriavidus necator (Alcaligenes eutrophus) - acnM gene Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate (PubMed:11495997). Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2S,3R)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity). Indicus|evm.model.PRDE01002120.1.1 Q6DGP2 SYF2_DANRE 60.274 0.231511 1.30672 syf2 - Pre-mRNA-splicing factor syf2 - Danio rerio (Zebrafish) - syf2 gene Involved in pre-mRNA splicing as component of the spliceosome. Indicus|evm.model.PRDE01002141.1.3 Q9HWF9 BFR_PSEAE 75.163 0.888889 1.11039 bfr - Bacterioferritin - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - bfr gene Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. Indicus|evm.model.PRDE01002141.1.4 Q88E10 MCPS_PSEPK 60.312 0.99688 1.00313 mcpS - Methyl-accepting chemotaxis protein McpS - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - mcpS gene Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. McpS is a specific chemoreceptor for 6 tricarboxylic acid (TCA) cycle intermediates (succinate, fumarate, malate, oxaloacetate, citrate and isocitrate), butyrate and acetate. Malate, succinate, fumarate and oxaloacetate cause the strongest chemotactic response. Indicus|evm.model.PRDE01002141.1.5 Q9HV30 Y4778_PSEAE 80.172 0.851852 1.02273 PA4778 - Uncharacterized HTH-type transcriptional regulator PA4778 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA4778 gene transcription regulatory region sequence-specific DNA binding, positive regulation of transcription, DNA-templated Indicus|evm.model.PRDE01002141.1.6 P32113 COPA_ENTHA 47.699 0.944 0.343879 copA - Probable copper-importing P-type ATPase A - Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R) - copA gene Probably involved in copper import under copper limiting conditions. Indicus|evm.model.PRDE01002152.1.1 O96693 DXR_PLAFX 46.154 0.989011 0.559426 DXR - 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic precursor - Plasmodium falciparum (isolate HB3) - DXR gene Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). Indicus|evm.model.PRDE01002167.1.1 Q9HZP6 ETFB_PSEAE 94.798 0.99422 0.694779 etfB - Electron transfer flavoprotein subunit beta - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - etfB gene The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Indicus|evm.model.PRDE01002183.1.1 Q8RX88 FACE1_ARATH 48.077 0.69863 0.17217 FACE1 - CAAX prenyl protease 1 homolog - Arabidopsis thaliana (Mouse-ear cress) - FACE1 gene Proteolytically removes the C-terminal three residues of farnesylated proteins. The substrate specificity is only partially overlapping with that of FACE2. Indicus|evm.model.PRDE01002188.1.2 P0ABC9 BETT_ECOLI 44.340 0.97205 0.475628 betT - High-affinity choline transport protein - Escherichia coli (strain K12) - betT gene High-affinity uptake of choline driven by a proton-motive force. Indicus|evm.model.PRDE01002210.1.1 P73452 NRTA_SYNY3 66.798 0.936803 0.603139 nrtA - Nitrate/nitrite binding protein NrtA precursor - Synechocystis sp. (strain PCC 6803 / Kazusa) - nrtA gene Part of the ABC transporter complex NrtABCD involved in nitrate uptake (PubMed:16777960). The complex is probably also involved in nitrite transport (By similarity). NrtA is the substrate-binding protein (PubMed:16777960). Binds nitrate (PubMed:16777960). Indicus|evm.model.PRDE01002238.1.1 Q88JU3 DSD_PSEPK 72.818 0.997506 0.631496 quiC1 - 3-dehydroshikimate dehydratase - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - quiC1 gene Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. Indicus|evm.model.PRDE01002285.1.1 Q9NSE4 SYIM_HUMAN 79.775 0.988764 0.0879447 IARS2 - Isoleucine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - IARS2 gene mitochondrial matrix, mitochondrion, isoleucine-tRNA ligase activity, isoleucyl-tRNA aminoacylation, mitochondrial translation, tRNA aminoacylation for protein translation Indicus|evm.model.PRDE01002298.1.1 D3ZJP6 MYO10_RAT 98.148 0.56383 0.0456311 Myo10 - Unconventional myosin-X - Rattus norvegicus (Rat) - Myo10 gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts (By similarity). Stimulates the formation and elongation of filopodia. Indicus|evm.model.PRDE01002337.1.1 Q4UFS9 RS8_THEAN 97.872 0.989418 1.02717 RPS8 - 40S ribosomal protein S8 - Theileria annulata - RPS8 gene Indicus|evm.model.PRDE01002342.1.1 C0ZXN2 LEUD_RHOE4 76.074 0.97006 0.826733 leuD - 3-isopropylmalate dehydratase small subunit - Rhodococcus erythropolis (strain PR4 / NBRC 100887) - leuD gene Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. Indicus|evm.model.PRDE01002345.1.1 A7YY62 F16A2_BOVIN 99.231 0.935018 0.284687 FHIP1B - FHF complex subunit HOOK interacting protein 1B - Bos taurus (Bovine) - FHIP1B gene Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. Indicus|evm.model.PRDE01002374.1.1 P30864 YAFC_ECOLI 46.117 0.940367 0.717105 yafC - Uncharacterized HTH-type transcriptional regulator YafC - Escherichia coli (strain K12) - yafC gene transcription regulatory region sequence-specific DNA binding, regulation of transcription, DNA-templated, response to ionizing radiation Indicus|evm.model.PRDE01002412.1.1 P25888 RHLE_ECOLI 61.808 0.608929 1.23348 rhlE - ATP-dependent RNA helicase RhlE - Escherichia coli (strain K12) - rhlE gene DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA. May play a role in the interconversion of ribosomal RNA-folding intermediates that are further processed by DeaD or SrmB during ribosome maturation. Indicus|evm.model.PRDE01002412.1.2 Q51487 OPRM_PSEAE 70.861 0.965591 0.958763 oprM - Outer membrane protein OprM precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - oprM gene The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the MexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane. Indicus|evm.model.PRDE01002412.1.3 P52002 MEXB_PSEAE 78.333 0.954787 0.359465 mexB - Multidrug resistance protein MexB - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - mexB gene The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine. Indicus|evm.model.PRDE01002453.1.2 Q59224 DHPH_BACBA 66.055 0.81203 0.35 pdh - Phenylalanine dehydrogenase - Bacillus badius - pdh gene Catalyzes the reversible NAD(+)-dependent oxidative deamination of L-phenylalanine to phenylpyruvate. Is also able to act on L-tyrosine, but with 100-fold lower efficiency. Indicus|evm.model.PRDE01002505.1.1 Q9N2I8 TRXR2_BOVIN 96.491 0.965517 0.113503 TXNRD2 - Thioredoxin reductase 2, mitochondrial precursor - Bos taurus (Bovine) - TXNRD2 gene Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. Indicus|evm.model.PRDE01002552.1.4 Q883T5 GREB_PSESM 62.602 0.938462 0.828025 greB - Transcription elongation factor GreB - Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) - greB gene Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. Indicus|evm.model.PRDE01002552.1.6 Q9HZY5 GREB_PSEAE 89.157 0.987952 0.494048 greB - Transcription elongation factor GreB - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - greB gene Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. Indicus|evm.model.PRDE01002554.1.1 Q1IGZ0 METN2_PSEE4 85.535 0.721461 0.653731 metN2 - Methionine import ATP-binding protein MetN 2 - Pseudomonas entomophila (strain L48) - metN2 gene Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01002564.1.1 Q52369 CYC4_PSEST 36.559 0.706897 1.10476 cc4 - Cytochrome c4 precursor - Pseudomonas stutzeri - cc4 gene Diheme, high potential cytochrome c believed to be an intermediate electron donor to terminal oxidation systems. Indicus|evm.model.PRDE01002564.1.2 P25524 CODA_ECOLI 62.238 0.97931 0.339578 codA - Cytosine deaminase - Escherichia coli (strain K12) - codA gene Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5-fluorocytosine (5FC) to 5-fluorouracil (5FU); this activity allows the formation of a cytotoxic chemotherapeutic agent from a non-cytotoxic precursor. Indicus|evm.model.PRDE01002565.1.1 Q52369 CYC4_PSEST 37.097 0.706897 1.10476 cc4 - Cytochrome c4 precursor - Pseudomonas stutzeri - cc4 gene Diheme, high potential cytochrome c believed to be an intermediate electron donor to terminal oxidation systems. Indicus|evm.model.PRDE01002565.1.2 P25524 CODA_ECOLI 62.238 0.97931 0.339578 codA - Cytosine deaminase - Escherichia coli (strain K12) - codA gene Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5-fluorocytosine (5FC) to 5-fluorouracil (5FU); this activity allows the formation of a cytotoxic chemotherapeutic agent from a non-cytotoxic precursor. Indicus|evm.model.PRDE01002583.1.1 Q03001 DYST_HUMAN 93.220 0.983051 0.00779392 DST - Dystonin - Homo sapiens (Human) - DST gene Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). Indicus|evm.model.PRDE01002683.1.1 Q5YP36 DEOC_NOCFA 64.045 0.977901 0.815315 deoC - Deoxyribose-phosphate aldolase - Nocardia farcinica (strain IFM 10152) - deoC gene Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Indicus|evm.model.PRDE01002689.1.1 Q9UPU7 TBD2B_HUMAN 91.463 0.663934 0.126687 TBC1D2B - TBC1 domain family member 2B - Homo sapiens (Human) - TBC1D2B gene May act as a GTPase-activating protein. Indicus|evm.model.PRDE01002696.1.1 A4VI15 TRMA_PSEU5 100.000 0.968254 0.174033 trmA - tRNA/tmRNA (uracil-C(5))-methyltransferase - Pseudomonas stutzeri (strain A1501) - trmA gene Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). Indicus|evm.model.PRDE01002732.1.1 A4VR88 BIOB_PSEU5 97.348 0.988722 0.757835 bioB - Biotin synthase - Pseudomonas stutzeri (strain A1501) - bioB gene Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism. Indicus|evm.model.PRDE01002732.1.3 P0C0K3 SRKA_ECOLI 47.335 0.978462 0.990854 srkA - Stress response kinase A - Escherichia coli (strain K12) - srkA gene A protein kinase that (auto)phosphorylates on Ser and Thr residues (PubMed:17302814). Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Protects cells from stress by antagonizing the MazE-MazF TA module, probably indirectly as it has not been seen to phosphorylate MazE, MazF or MazG (PubMed:23416055). Probably involved in the extracytoplasmic stress response (PubMed:9159398). Indicus|evm.model.PRDE01002733.1.1 P22670 RFX1_HUMAN 96.269 0.985185 0.137896 RFX1 - MHC class II regulatory factor RFX1 - Homo sapiens (Human) - RFX1 gene Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. Indicus|evm.model.PRDE01002824.1.1 Q5JU00 DRC5_HUMAN 88.406 0.971429 0.139721 TCTE1 - Dynein regulatory complex subunit 5 - Homo sapiens (Human) - TCTE1 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility. Indicus|evm.model.PRDE01002843.1.1 P01876 IGHA1_HUMAN 85.385 0.984733 0.371105 IGHA1 - Immunoglobulin heavy constant alpha 1 - Homo sapiens (Human) - IGHA1 gene Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915). Indicus|evm.model.PRDE01002849.1.1 Q6IQ23 PKHA7_HUMAN 97.297 0.973333 0.0669045 PLEKHA7 - Pleckstrin homology domain-containing family A member 7 - Homo sapiens (Human) - PLEKHA7 gene Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). Indicus|evm.model.PRDE01002859.1.1 Q56P42 PYDC2_HUMAN 60.811 0.986486 0.762887 PYDC2 - Pyrin domain-containing protein 2 - Homo sapiens (Human) - PYDC2 gene May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17339483, PubMed:17178784). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464). Indicus|evm.model.PRDE01002865.1.1 P23620 PHOB_PSEAE 92.920 0.99115 0.49345 phoB - Phosphate regulon transcriptional regulatory protein PhoB - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - phoB gene This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited. Indicus|evm.model.PRDE01002865.1.2 A4VGN3 UBIA_PSEU5 94.613 0.961039 1.03704 ubiA - 4-hydroxybenzoate octaprenyltransferase - Pseudomonas stutzeri (strain A1501) - ubiA gene Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. Indicus|evm.model.PRDE01002886.1.2 Q3ULD5 MCCB_MOUSE 65.858 0.996269 0.952043 Mccc2 - Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor - Mus musculus (Mouse) - Mccc2 gene Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. Indicus|evm.model.PRDE01002942.1.1 Q562B4 NACC2_RAT 98.611 0.986111 0.123077 Nacc2 - Nucleus accumbens-associated protein 2 - Rattus norvegicus (Rat) - Nacc2 gene Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity). Indicus|evm.model.PRDE01002944.1.1 Q07252 MEMP_CUPNH 73.002 0.933333 0.964912 H16_A0667 - Membrane protein - Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) - H16_A0667 gene Indicus|evm.model.PRDE01002944.1.2 P95539 CATE_PSEPU 68.802 0.995859 0.679325 katE - Catalase HPII - Pseudomonas putida - katE gene Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Indicus|evm.model.PRDE01002945.1.2 P31521 P47K_PSECL 55.882 0.936111 0.859189 47 kDa protein - Pseudomonas chlororaphis Indicus|evm.model.PRDE01002975.1.1 P45117 URAA_HAEIN 66.327 0.9375 0.502415 uraA - Probable uracil permease - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - uraA gene Transport of uracil in the cell. Indicus|evm.model.PRDE01002975.1.3 Q9HVD1 PAGL_PSEAE 67.532 0.974359 0.901734 pagL - Lipid A deacylase PagL precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pagL gene Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety. Lacks fatty acyl chain-length specificity as removes both 3-OH C10 and 3-OH C14 fatty acids from lipid A. Indicus|evm.model.PRDE01002975.1.4 A4VPB6 MURI_PSEU5 82.474 0.827586 0.439394 murI - Glutamate racemase - Pseudomonas stutzeri (strain A1501) - murI gene Provides the (R)-glutamate required for cell wall biosynthesis. Indicus|evm.model.PRDE01002976.1.1 P45117 URAA_HAEIN 67.876 0.923077 0.502415 uraA - Probable uracil permease - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - uraA gene Transport of uracil in the cell. Indicus|evm.model.PRDE01002976.1.3 Q9HVD1 PAGL_PSEAE 67.532 0.974359 0.901734 pagL - Lipid A deacylase PagL precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pagL gene Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety. Lacks fatty acyl chain-length specificity as removes both 3-OH C10 and 3-OH C14 fatty acids from lipid A. Indicus|evm.model.PRDE01002976.1.4 A4VPB6 MURI_PSEU5 84.536 0.96 0.378788 murI - Glutamate racemase - Pseudomonas stutzeri (strain A1501) - murI gene Provides the (R)-glutamate required for cell wall biosynthesis. Indicus|evm.model.PRDE01003013.1.1 P64762 Y965_MYCBO 45.238 0.741071 0.388889 BQ2027_MB0965C - Uncharacterized protein Mb0965c - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - BQ2027_MB0965C gene Indicus|evm.model.PRDE01003025.1.1 O31215 CYB_ALLVD 63.240 0.996805 0.756039 petB - Cytochrome b - Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D) - petB gene Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. Indicus|evm.model.PRDE01003028.1.4 O50274 CYSNC_PSEAE 83.431 0.996101 0.810427 cysNC - Bifunctional enzyme CysN/CysC - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - cysNC gene ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity. Indicus|evm.model.PRDE01003034.1.1 P53492 ACT7_ARATH 46.284 0.983165 0.787798 ACT7 - Actin-7 - Arabidopsis thaliana (Mouse-ear cress) - ACT7 gene Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (PubMed:11449050). Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth (PubMed:11449050). This is considered as one of the vegetative actins which is involved in the regulation of hormone-induced plant cell proliferation and callus formation (PubMed:11449050). Required for the trafficking and endocytic recycling of ABCG36/PEN3 between the trans-Golgi network and the plasma membrane in root epidermal and cap cells (PubMed:27803190). Indicus|evm.model.PRDE01003054.1.1 A6W828 DAPA_KINRD 57.500 0.806122 0.318182 dapA - 4-hydroxy-tetrahydrodipicolinate synthase - Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) - dapA gene Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). Indicus|evm.model.PRDE01003114.1.1 Q7YRJ7 SOX9_CANLF 88.462 0.786585 0.319688 SOX9 - Transcription factor SOX-9 - Canis lupus familiaris (Dog) - SOX9 gene Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6. Also binds to some promoter regions. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression. Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C. Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes. Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors. In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix. Controls epithelial branching during kidney development. Indicus|evm.model.PRDE01003148.1.1 Q9HX97 MOAE_PSEAE 80.667 0.973856 1.02 moaE - Molybdopterin synthase catalytic subunit - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - moaE gene Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity). Indicus|evm.model.PRDE01003153.1.1 A4VRA1 NHAP2_PSEU5 96.330 0.993902 0.564544 nhaP2 - K(+)/H(+) antiporter NhaP2 - Pseudomonas stutzeri (strain A1501) - nhaP2 gene K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels. Indicus|evm.model.PRDE01003154.1.1 A4VRA1 NHAP2_PSEU5 95.963 0.993808 0.555938 nhaP2 - K(+)/H(+) antiporter NhaP2 - Pseudomonas stutzeri (strain A1501) - nhaP2 gene K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels. Indicus|evm.model.PRDE01003159.1.1 P51961 RISA_PHOPO 58.427 0.994382 0.816514 ribE - Riboflavin synthase - Photobacterium phosphoreum - ribE gene Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil. Indicus|evm.model.PRDE01003171.1.3 Q47152 RAYT_ECOLI 48.851 0.977401 1.07273 rayT - REP-associated tyrosine transposase - Escherichia coli (strain K12) - rayT gene Transposase that is always flanked by repeated extragenic palindrome (REP) sequences, which are clustered in structures called bacterial interspersed mosaic elements (BIMEs). RayT catalyzes cleavage and recombination of BIMEs. Binds REP sequences and cleaves BIMEs both upstream and downstream of the REP sequence. Could be important in the creation of BIME variability and amplification. Indicus|evm.model.PRDE01003171.1.5 Q9Z6S4 RIR2_CHLPN 56.604 0.985981 0.618497 nrdB - Ribonucleoside-diphosphate reductase subunit beta - Chlamydia pneumoniae - nrdB gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Indicus|evm.model.PRDE01003176.1.1 Q9I2A0 LIUE_PSEAE 79.649 0.628319 1.50667 liuE - 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - liuE gene Involved in the L-leucine, isovalerate and acyclic monoterpene catabolism. Catalyzes the cleavage of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to yield acetyl-CoA and acetoacetate. It can also catalyze the cleavage of 3-hydroxy-3-isohexenylglutaryl-CoA (HIHG_CoA) to yield 7-methyl-3-oxooct-6-enoyl-CoA and acetate. Indicus|evm.model.PRDE01003176.1.2 B0RVK4 SCOA_XANCB 76.974 0.980519 0.636364 lpsI - Succinyl-CoA:3-ketoacid coenzyme A transferase subunit A - Xanthomonas campestris pv. campestris (strain B100) - lpsI gene Indicus|evm.model.PRDE01003184.1.1 P23388 PTFAX_RHOCA 48.255 0.618926 0.945586 fruB(HI) - Multiphosphoryl transfer protein - Rhodobacter capsulatus - fruB(HI) gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. Indicus|evm.model.PRDE01003184.1.2 P20966 PTFBC_ECOLI 50.000 0.708661 0.451155 fruA - PTS system fructose-specific EIIB'BC component - Escherichia coli (strain K12) - fruA gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. Indicus|evm.model.PRDE01003222.1.1 A4VHG9 TSAD_PSEU5 95.601 0.894737 1.11437 tsaD - tRNA N6-adenosine threonylcarbamoyltransferase - Pseudomonas stutzeri (strain A1501) - tsaD gene Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. Indicus|evm.model.PRDE01003222.1.2 Q3K5S2 PLSY_PSEPF 74.830 0.986486 0.783069 plsY - Glycerol-3-phosphate acyltransferase - Pseudomonas fluorescens (strain Pf0-1) - plsY gene Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. Indicus|evm.model.PRDE01003282.1.1 P98167 SSPO_BOVIN 100.000 0.902439 0.0398368 SSPO - SCO-spondin precursor - Bos taurus (Bovine) - SSPO gene Involved in the modulation of neuronal aggregation (PubMed:8743952). May be involved in developmental events during the formation of the central nervous system (PubMed:11008217). Indicus|evm.model.PRDE01003299.1.1 Q00517 GSPJ_PSEAE 54.229 0.97561 0.864979 xcpW - Type II secretion system protein J precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - xcpW gene Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm (PubMed:9282737). Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates (PubMed:19828448, PubMed:30346996). Type II pseudopilus confers increased bacterial adhesive capabilities (PubMed:12700254). Indicus|evm.model.PRDE01003332.1.2 P60230 TRA1_MYCTU 64.878 0.978469 1.00723 Rv1199c - Transposase for insertion sequence element IS1081 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1199c gene Required for the transposition of the insertion element. Indicus|evm.model.PRDE01003358.1.1 P72158 PURK_PSEAE 91.154 0.996154 0.722222 purK - N5-carboxyaminoimidazole ribonucleotide synthase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - purK gene Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). Indicus|evm.model.PRDE01003361.1.1 P52684 MAUR_KLEPN 47.667 0.943038 1.02597 mauR - Malonate utilization transcriptional regulator - Klebsiella pneumoniae - mauR gene Transcriptional regulator of the mau genes for malonate utilization. Indicus|evm.model.PRDE01003371.1.1 O75051 PLXA2_HUMAN 100.000 0.9875 0.0422386 PLXNA2 - Plexin-A2 precursor - Homo sapiens (Human) - PLXNA2 gene Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). Indicus|evm.model.PRDE01003379.1.1 P76298 FLHA_ECOLI 46.798 0.980583 0.297688 flhA - Flagellar biosynthesis protein FlhA - Escherichia coli (strain K12) - flhA gene Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. Indicus|evm.model.PRDE01003379.1.2 G3XD64 FLEN_PSEAE 86.145 0.299456 1.96786 fleN - Antiactivator FleN - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - fleN gene ATPase that plays an important role in maintaining flagellar number in Pseudomonas aeruginosa (PubMed:10629180, PubMed:28065505). Exhibits anti-activator activity against FleQ, the global transcriptional regulator of flagellar genes (PubMed:22581773, PubMed:28065505). Indicus|evm.model.PRDE01003394.1.1 P58802 TB10A_MOUSE 89.706 0.638095 0.21 Tbc1d10a - TBC1 domain family member 10A - Mus musculus (Mouse) - Tbc1d10a gene Acts as GTPase-activating protein for RAB27A. Indicus|evm.model.PRDE01003396.1.1 Q51465 FLIM_PSEAE 93.033 0.995902 0.755418 fliM - Flagellar motor switch protein FliM - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - fliM gene FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). Indicus|evm.model.PRDE01003400.1.1 Q02817 MUC2_HUMAN 69.608 0.40239 0.048465 MUC2 - Mucin-2 precursor - Homo sapiens (Human) - MUC2 gene Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. Indicus|evm.model.PRDE01003409.1.2 A4XPG4 PGK_PSEMY 91.304 0.558282 0.42228 pgk - Phosphoglycerate kinase - Pseudomonas mendocina (strain ymp) - pgk gene Indicus|evm.model.PRDE01003419.1.1 Q9SIP7 RS31_ARATH 74.766 0.768953 1.108 RPS3A - 40S ribosomal protein S3-1 - Arabidopsis thaliana (Mouse-ear cress) - RPS3A gene chloroplast, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleus, peroxisome, plasmodesma, vacuolar membrane, vacuole, mRNA binding Indicus|evm.model.PRDE01003440.1.2 A4VR87 BIOF_PSEU5 92.130 0.990783 0.553571 bioF - 8-amino-7-oxononanoate synthase - Pseudomonas stutzeri (strain A1501) - bioF gene Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Indicus|evm.model.PRDE01003620.1.1 P29248 FLIA_PSEAE 87.500 0.969388 0.396761 fliA - RNA polymerase sigma factor FliA - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - fliA gene Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes (By similarity). Required for the flagellin gene (fliC) expression. Indicus|evm.model.PRDE01003622.1.1 Q9HZ00 Y3240_PSEAE 66.071 0.982206 0.985965 PA3240 - Putative quercetin 2,3-dioxygenase PA3240 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA3240 gene Putative quercetin 2,3-dioxygenase. Indicus|evm.model.PRDE01003639.1.1 P31033 MTM4_NEIGO 72.381 0.971963 0.342949 ngoMIVM - Modification methylase NgoMIV - Neisseria gonorrhoeae - ngoMIVM gene This methylase recognizes the double-stranded sequence GCCGGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the ngomIV endonuclease. Indicus|evm.model.PRDE01003737.1.1 B6KG46 CATIN_TOXGV 57.895 0.0866511 0.62064 CACTIN - Cactin - Toxoplasma gondii (strain ATCC 50861 / VEG) - CACTIN gene Involved in the regulation of G1 progression and stage differentiation of tachyzoites. May play a role in gene expression. Indicus|evm.model.PRDE01003764.1.1 P9WNA3 FTSK_MYCTU 83.913 0.995652 0.276775 ftsK - DNA translocase FtsK - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ftsK gene Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). Indicus|evm.model.PRDE01003809.1.1 P22609 PILC_PSEAE 81.571 0.993976 0.887701 pilC - Type IV pilus assembly protein PilC - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pilC gene Essential inner membrane component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers. Controls both pilus assembly and disassembly and plays an important role in PilB localization to the complex and ATPase activity. Indicus|evm.model.PRDE01003809.1.2 P22608 PILB_PSEAE 80.600 0.996479 1.00353 pilB - Type IV pilus assembly ATPase PilB - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pilB gene ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers (PubMed:15659660, PubMed:28854278). Acts as a molecular motor to provide the energy that is required for biogenesis of the pilus and the extrusion of substrates generated in the cytoplasm (PubMed:8102361, PubMed:18174131). PilB ATPase activity is also essential for T4P extension while antagonist PilT ATPase activity is required for T4P retraction (By similarity). Indicus|evm.model.PRDE01003858.1.1 A4VRA3 SELO_PSEU5 98.025 0.995074 0.835391 selO - Protein adenylyltransferase SelO - Pseudomonas stutzeri (strain A1501) - selO gene Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). Indicus|evm.model.PRDE01003925.1.1 P9WFW9 MENF_MYCTU 59.333 0.886905 0.451613 menF - Putative isochorismate synthase MenF - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - menF gene Catalyzes the conversion of chorismate to isochorismate. Indicus|evm.model.PRDE01003945.1.1 B1VIK2 PUR7_CORU7 74.603 0.96875 0.215488 purC - Phosphoribosylaminoimidazole-succinocarboxamide synthase - Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109) - purC gene Indicus|evm.model.PRDE01003955.1.1 P9WNZ3 DESA3_MYCTU 57.407 0.981481 0.126464 desA3 - NADPH-dependent stearoyl-CoA 9-desaturase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - desA3 gene Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. Indicus|evm.model.PRDE01003977.1.1 P39830 YBAL_ECOLI 62.846 0.996047 0.453405 ybaL - Putative cation/proton antiporter YbaL - Escherichia coli (strain K12) - ybaL gene plasma membrane Indicus|evm.model.PRDE01003987.1.2 Q9WTR7 SC11C_RAT 60.000 0.898876 0.463542 Sec11c - Signal peptidase complex catalytic subunit SEC11C - Rattus norvegicus (Rat) - Sec11c gene Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Indicus|evm.model.PRDE01003995.1.1 P38942 CAT2_CLOK5 56.667 0.797297 0.172494 cat2 - 4-hydroxybutyrate coenzyme A transferase - Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) - cat2 gene Indicus|evm.model.PRDE01004026.1.1 B5MCY1 TDR15_HUMAN 73.034 0.985158 0.278697 TDRD15 - Tudor domain-containing protein 15 - Homo sapiens (Human) - TDRD15 gene Indicus|evm.model.PRDE01004047.1.1 P9WN53 GCSP_MYCTU 84.615 0.447059 0.0903294 gcvP - Probable glycine dehydrogenase (decarboxylating) - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - gcvP gene The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity). Indicus|evm.model.PRDE01004059.1.1 A4VPB2 UPP_PSEU5 95.283 0.99061 1.00472 upp - Uracil phosphoribosyltransferase - Pseudomonas stutzeri (strain A1501) - upp gene Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. Indicus|evm.model.PRDE01004059.1.2 P45117 URAA_HAEIN 75.000 0.75 0.202899 uraA - Probable uracil permease - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - uraA gene Transport of uracil in the cell. Indicus|evm.model.PRDE01004060.1.1 A4VPB2 UPP_PSEU5 97.170 0.99061 1.00472 upp - Uracil phosphoribosyltransferase - Pseudomonas stutzeri (strain A1501) - upp gene Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. Indicus|evm.model.PRDE01004060.1.2 P45117 URAA_HAEIN 63.529 0.893617 0.227053 uraA - Probable uracil permease - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - uraA gene Transport of uracil in the cell. Indicus|evm.model.PRDE01004070.1.1 P31833 COX1_BRADU 54.305 0.993056 0.266174 ctaD - Cytochrome c oxidase subunit 1 - Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) - ctaD gene Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. Indicus|evm.model.PRDE01004112.1.1 P31360 PO3F2_MOUSE 99.543 0.995434 0.492135 Pou3f2 - POU domain, class 3, transcription factor 2 - Mus musculus (Mouse) - Pou3f2 gene Transcription factor that plays a key role in neuronal differentiation (PubMed:24243019). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (PubMed:18505825, PubMed:18403418). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (PubMed:24243019). Indicus|evm.model.PRDE01004130.1.1 P21863 FKBX_PSEFL 79.787 0.978947 0.633333 yaaD - Probable FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase - Pseudomonas fluorescens - yaaD gene PPIases accelerate the folding of proteins. Indicus|evm.model.PRDE01004212.1.1 Q99PL5 RRBP1_MOUSE 82.222 0.934783 0.0573209 Rrbp1 - Ribosome-binding protein 1 - Mus musculus (Mouse) - Rrbp1 gene Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. Indicus|evm.model.PRDE01004275.1.1 I6Y9Q3 PRPC_MYCTU 73.958 0.896226 0.26972 prpC - 2-methylcitrate synthase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - prpC gene Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA. Indicus|evm.model.PRDE01004310.1.1 Q9Y5B0 CTDP1_HUMAN 85.714 0.887097 0.0645161 CTDP1 - RNA polymerase II subunit A C-terminal domain phosphatase - Homo sapiens (Human) - CTDP1 gene Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. Indicus|evm.model.PRDE01004339.1.1 A1B474 AROA_PARDP 92.623 0.991803 0.275395 aroA - 3-phosphoshikimate 1-carboxyvinyltransferase - Paracoccus denitrificans (strain Pd 1222) - aroA gene Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. Indicus|evm.model.PRDE01004359.1.1 O88854 GALR2_MOUSE 89.130 0.810651 0.455526 Galr2 - Galanin receptor type 2 - Mus musculus (Mouse) - Galr2 gene Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). Indicus|evm.model.PRDE01004382.1.1 Q9DBG7 SRPRA_MOUSE 100.000 0.982609 0.180818 Srpra - Signal recognition particle receptor subunit alpha - Mus musculus (Mouse) - Srpra gene Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). Indicus|evm.model.PRDE01004396.1.1 P31466 ADEP_ECOLI 51.256 0.985075 0.451685 adeP - Adenine permease AdeP - Escherichia coli (strain K12) - adeP gene High-affinity transporter for adenine. Indicus|evm.model.PRDE01004396.1.3 Q9I3J5 HIUH_PSEAE 72.727 0.98 0.793651 PA1518 - 5-hydroxyisourate hydrolase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA1518 gene Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). Indicus|evm.model.PRDE01004437.1.1 P34750 PILQ_PSEAE 77.922 0.995652 0.644258 pilQ - Fimbrial assembly protein PilQ precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pilQ gene Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane. Indicus|evm.model.PRDE01004456.1.1 P26877 LIP_PSEU0 69.000 0.970588 0.327974 lipL - Triacylglycerol lipase precursor - Pseudomonas sp. (strain 109) - lipL gene Catalyzes the hydrolysis of triacylglycerol. Also able to catalyze, in anhydrous organic solvents, intramolecular transesterification of omega-hydroxyfatty acid esters to form macrocyclic lactones. This biosynthesis is dependent on the chain length of the substrates, and the formation of monomer lactone is maximum with methyl 18-hydroxyoctadecanoate. With shorter substrates, monomer lactone decreases and the formation of diolide (dimer lactone) increases. Indicus|evm.model.PRDE01004483.1.1 O95154 ARK73_HUMAN 75.000 0.281768 0.546828 AKR7A3 - Aflatoxin B1 aldehyde reductase member 3 - Homo sapiens (Human) - AKR7A3 gene Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Indicus|evm.model.PRDE01004519.1.1 Q5CG95 ERF1_CRYHO 71.688 0.94898 0.913753 erf1 - Eukaryotic peptide chain release factor subunit 1 - Cryptosporidium hominis - erf1 gene Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Indicus|evm.model.PRDE01004565.1.1 Q08DF2 RN112_BOVIN 100.000 0.990476 0.334395 RNF112 - RING finger protein 112 - Bos taurus (Bovine) - RNF112 gene E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density. Indicus|evm.model.PRDE01004566.1.1 Q57180 Y1051_HAEIN 70.563 0.970464 0.385993 HI_1051 - Uncharacterized ABC transporter ATP-binding protein HI_1051 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_1051 gene ATPase-coupled lipid transmembrane transporter activity, ATPase-coupled transmembrane transporter activity, transmembrane transport Indicus|evm.model.PRDE01004569.1.2 A4VL35 LIFO_PSEU5 99.403 0.994048 1.00299 lifO - Lipase chaperone - Pseudomonas stutzeri (strain A1501) - lifO gene May be involved in the folding of the extracellular lipase during its passage through the periplasm. Indicus|evm.model.PRDE01004619.1.1 P19843 NOSD_PSEST 92.105 0.92638 0.373853 nosD - Probable ABC transporter binding protein NosD precursor - Pseudomonas stutzeri - nosD gene Required for the assembly of the copper chromophores of nitrous oxide reductase (PubMed:2170125). Could be part of the ABC transporter complex NosDFY (Probable). Indicus|evm.model.PRDE01004619.1.2 P19844 NOSF_PSEST 83.959 0.993197 0.954545 nosF - Probable ABC transporter ATP-binding protein NosF - Pseudomonas stutzeri - nosF gene Required for the assembly of the copper chromophores of nitrous oxide reductase (PubMed:2170125). Has ATPase activity (PubMed:12618453). Could be part of the ABC transporter complex NosDFY (Probable). Indicus|evm.model.PRDE01004619.1.3 P19845 NOSY_PSEST 98.000 0.98 0.181159 nosY - Probable ABC transporter permease protein NosY - Pseudomonas stutzeri - nosY gene Required for the assembly of the copper chromophores of nitrous oxide reductase (PubMed:2170125). Could be part of the ABC transporter complex NosDFY (Probable). Indicus|evm.model.PRDE01004678.1.1 Q3ZC55 ACTN2_BOVIN 100.000 0.525641 0.0872483 ACTN2 - Alpha-actinin-2 - Bos taurus (Bovine) - ACTN2 gene F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). Indicus|evm.model.PRDE01004730.1.1 Q08853 ATC_PLAFK 46.759 0.711921 0.737785 ATP6 - Calcium-transporting ATPase - Plasmodium falciparum (isolate K1 / Thailand) - ATP6 gene This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Indicus|evm.model.PRDE01004770.1.1 O94550 PHB2_SCHPO 65.574 0.972 0.868056 phb2 - Prohibitin-2 - Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) - phb2 gene Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Indicus|evm.model.PRDE01004774.1.1 P9WJV5 MMPL3_MYCTU 52.574 0.984127 0.266949 mmpL3 - Trehalose monomycolate exporter MmpL3 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - mmpL3 gene Transports trehalose monomycolate (TMM) to the cell wall. Flips TMM across the inner membrane (PubMed:22252828, PubMed:22344175). Membrane potential is not required for this function. Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL). Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness (By similarity). Could also be part of a heme-iron acquisition system (PubMed:21383189). Indicus|evm.model.PRDE01004785.1.1 G0S8G9 IF2P_CHATD 86.486 0.0798226 0.404122 CTHT_0029840 - Eukaryotic translation initiation factor 5B - Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) - CTHT_0029840 gene Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. Indicus|evm.model.PRDE01004819.1.1 Q0VFX8 CRIP2_BOVIN 98.089 0.8125 0.923077 CRIP2 - Cysteine-rich protein 2 - Bos taurus (Bovine) - CRIP2 gene Indicus|evm.model.PRDE01004833.1.1 Q5ZJ75 SL9A8_CHICK 93.333 0.967213 0.106272 Sodium/hydrogen exchanger 8 - Gallus gallus (Chicken) Indicus|evm.model.PRDE01004835.1.1 Q6QN14 U17L6_HUMAN 65.854 0.515924 0.394472 USP17L6P - Ubiquitin carboxyl-terminal hydrolase 17-like protein 6 - Homo sapiens (Human) - USP17L6P gene Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, cell migration, and the cellular response to viral infection. Seems to be non-functional in the regulation of apoptosis. Indicus|evm.model.PRDE01004932.1.1 P25718 AMY1_ECOLI 53.333 0.986111 0.426036 malS - Periplasmic alpha-amylase precursor - Escherichia coli (strain K12) - malS gene Since only maltooligosaccharides up to a chain length of 6 glucose units are actively transported through the cytoplasmic membrane via the membrane-bound complex of three proteins, MalF, MalG, and MalK, longer maltooligosaccharides must first be degraded by the periplasmic alpha-amylase, the MalS protein. Indicus|evm.model.PRDE01004950.1.1 Q2T9T5 LRC61_BOVIN 98.639 0.986486 0.56705 LRRC61 - Leucine-rich repeat-containing protein 61 - Bos taurus (Bovine) - LRRC61 gene Indicus|evm.model.PRDE01004980.1.1 Q87VK2 RLMB_PSESM 87.295 0.33844 2.872 rlmB - 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB - Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) - rlmB gene Specifically methylates the ribose of guanosine 2251 in 23S rRNA. Indicus|evm.model.PRDE01005015.1.1 O34873 HMGCL_BACSU 46.541 0.827225 0.638796 yngG - Hydroxymethylglutaryl-CoA lyase YngG - Bacillus subtilis (strain 168) - yngG gene Involved in the catabolism of branched amino acids such as leucine. Indicus|evm.model.PRDE01005015.1.4 Q9HU18 DCTP_PSEAE 78.292 0.992908 0.851964 dctP - C4-dicarboxylate-binding periplasmic protein DctP precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - dctP gene Part of the tripartite ATP-independent periplasmic (TRAP) transport system DctPQM involved in C4-dicarboxylates uptake. Indicus|evm.model.PRDE01005046.1.2 Q88D09 MCPQ_PSEPK 58.537 0.981928 0.260188 mcpQ - Methyl-accepting chemotaxis protein McpQ - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - mcpQ gene Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. McpQ recognizes specifically citrate and citrate/metal(2+) complexes. Binds citrate/metal(2+) complexes with higher affinity than free citrate, and mediates preferentially chemotaxis toward citrate/metal(2+) complexes. Indicus|evm.model.PRDE01005071.1.1 Q54E49 DDX6_DICDI 73.930 0.988417 0.612293 ddx6 - Probable ATP-dependent RNA helicase ddx6 - Dictyostelium discoideum (Slime mold) - ddx6 gene ATP-dependent RNA helicase which may be involved in mRNA turnover. Indicus|evm.model.PRDE01005080.1.1 A4VIE6 CYSD_PSEU5 94.426 0.993464 1.00328 cysD - Sulfate adenylyltransferase subunit 2 - Pseudomonas stutzeri (strain A1501) - cysD gene Indicus|evm.model.PRDE01005082.1.1 Q9I702 BAUC_PSEAE 62.600 0.994012 1.00805 bauC - Putative 3-oxopropanoate dehydrogenase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - bauC gene Involved in the degradation of beta-alanine. Indicus|evm.model.PRDE01005083.1.1 Q9I702 BAUC_PSEAE 60.714 0.965174 0.404427 bauC - Putative 3-oxopropanoate dehydrogenase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - bauC gene Involved in the degradation of beta-alanine. Indicus|evm.model.PRDE01005110.1.1 P23439 PDE6B_BOVIN 96.330 0.849206 0.147714 PDE6B - Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor - Bos taurus (Bovine) - PDE6B gene Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal (By similarity). Indicus|evm.model.PRDE01005147.1.1 Q00218 AROG_ARATH 60.791 0.992806 0.548323 DHS2 - Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic precursor - Arabidopsis thaliana (Mouse-ear cress) - DHS2 gene chloroplast, chloroplast thylakoid, plasma membrane Indicus|evm.model.PRDE01005192.1.1 P61810 CD5R1_RAT 100.000 0.985075 0.218241 Cdk5r1 - Cyclin-dependent kinase 5 activator 1 precursor - Rattus norvegicus (Rat) - Cdk5r1 gene p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity). Indicus|evm.model.PRDE01005223.1.1 P58939 CARB_CORGL 90.164 0.98374 0.110512 carB - Carbamoyl-phosphate synthase large chain - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - carB gene Indicus|evm.model.PRDE01005229.1.1 A4VPB9 RF1_PSEU5 99.103 0.995516 0.619444 prfA - Peptide chain release factor 1 - Pseudomonas stutzeri (strain A1501) - prfA gene Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. Indicus|evm.model.PRDE01005271.1.1 A4VFW8 SELA_PSEU5 97.162 0.535129 1.8209 selA - L-seryl-tRNA(Sec) selenium transferase - Pseudomonas stutzeri (strain A1501) - selA gene Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. Indicus|evm.model.PRDE01005271.1.2 P14081 SELB_ECOLI 55.224 0.985185 0.21987 selB - Selenocysteine-specific elongation factor - Escherichia coli (strain K12) - selB gene Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP. Indicus|evm.model.PRDE01005292.1.1 P10775 RINI_PIG 82.746 0.98951 0.627193 RNH1 - Ribonuclease inhibitor - Sus scrofa (Pig) - RNH1 gene Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. Indicus|evm.model.PRDE01005307.1.1 P35716 SOX11_HUMAN 80.075 0.966543 0.609977 SOX11 - Transcription factor SOX-11 - Homo sapiens (Human) - SOX11 gene Transcription factor that acts as a transcriptional activator (PubMed:24886874). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). Indicus|evm.model.PRDE01005322.1.1 A1L504 LMF2_BOVIN 97.674 0.726496 0.16643 LMF2 - Lipase maturation factor 2 - Bos taurus (Bovine) - LMF2 gene Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity). Indicus|evm.model.PRDE01005351.1.1 Q7TMI3 UHRF2_MOUSE 100.000 0.980392 0.0635118 Uhrf2 - E3 ubiquitin-protein ligase UHRF2 - Mus musculus (Mouse) - Uhrf2 gene E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity). E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Indicus|evm.model.PRDE01005417.1.1 P19622 HME2_HUMAN 83.333 0.65812 0.351351 EN2 - Homeobox protein engrailed-2 - Homo sapiens (Human) - EN2 gene chromatin, fibrillar center, nucleolus, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, multicellular organism development, neuron differentiation Indicus|evm.model.PRDE01005463.1.1 F4I9J7 Y14_ARATH 57.746 0.0830368 4.17327 Y14 - RNA-binding protein Y14 - Arabidopsis thaliana (Mouse-ear cress) - Y14 gene Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGO-Y14 heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGO-Y14 heterodimer interacts with the EJC key regulator PYM leading to EJC disassembly in the cytoplasm (By similarity). Can increase in vitro the expression from reporter constructs that contain leader introns required for the expression of different genes. In association with MAGO and PYM, participates in intron-mediated enhancement of gene expression (PubMed:21676911). The MAGO-Y14 heterodimer works synergistically with the NMD pathway to regulate male gametophyte development (PubMed:26867216). Indicus|evm.model.PRDE01005511.1.1 P31152 MK04_HUMAN 93.750 0.552941 0.144804 MAPK4 - Mitogen-activated protein kinase 4 - Homo sapiens (Human) - MAPK4 gene Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). Indicus|evm.model.PRDE01005528.1.1 P20702 ITAX_HUMAN 67.797 0.991453 0.100602 ITGAX - Integrin alpha-X precursor - Homo sapiens (Human) - ITGAX gene Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Indicus|evm.model.PRDE01005530.1.1 Q52528 NORD_PSEST 95.492 0.991837 0.400327 norD - Protein NorD - Pseudomonas stutzeri - norD gene Component of the anaerobic respiratory chain that transforms nitrate to dinitrogen (denitrification). Indicus|evm.model.PRDE01005534.1.1 P9WNP7 FADB2_MYCTU 64.017 0.944444 0.881119 fadB2 - 3-hydroxybutyryl-CoA dehydrogenase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - fadB2 gene Catalyzes the NAD-dependent oxidation of beta-hydroxybutyryl-CoA to acetoacetyl-CoA in vitro at pH 10. Also catalyzes the reverse reaction albeit in a lower pH range of 5.5-6.5. The reverse reaction is able to use NADPH as well as NADH. Indicus|evm.model.PRDE01005541.1.1 C8VK14 HXNY_EMENI 47.508 0.593186 1.4298 hxnY - 2-oxoglutarate-Fe(II) type oxidoreductase hxnY - Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) - hxnY gene 2-oxoglutarate-Fe(II) type oxidoreductase, part of the hnx cluster involved in the purine degradation (PubMed:29212709). The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism (PubMed:29212709). The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid (PubMed:29212709). Indicus|evm.model.PRDE01005581.1.2 P51906 EAA3_MOUSE 53.846 0.971698 0.202677 Slc1a1 - Excitatory amino acid transporter 3 - Mus musculus (Mouse) - Slc1a1 gene Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:12119102, PubMed:18684713). Can also transport L-cysteine (PubMed:30840898). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:9233792). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (PubMed:9233792). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (PubMed:30840898). Negatively regulated by ARL6IP5 (PubMed:12119102). Indicus|evm.model.PRDE01005618.1.1 P54810 THIL_PARDE 64.545 0.990291 0.263427 phaA - Acetyl-CoA acetyltransferase - Paracoccus denitrificans - phaA gene Indicus|evm.model.PRDE01005620.1.1 P95539 CATE_PSEPU 85.577 0.971831 0.299578 katE - Catalase HPII - Pseudomonas putida - katE gene Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Indicus|evm.model.PRDE01005626.1.1 Q4R642 DRC5_MACFA 86.243 0.994709 0.377246 TCTE1 - Dynein regulatory complex subunit 5 - Macaca fascicularis (Crab-eating macaque) - TCTE1 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility. Indicus|evm.model.PRDE01005644.1.1 O43526 KCNQ2_HUMAN 100.000 0.98 0.114679 KCNQ2 - Potassium voltage-gated channel subfamily KQT member 2 - Homo sapiens (Human) - KCNQ2 gene Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873). Indicus|evm.model.PRDE01005712.1.1 P64770 Y978_MYCBO 68.939 0.985019 0.946809 BQ2027_MB0978C - Uncharacterized protein Mb0978c - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - BQ2027_MB0978C gene Indicus|evm.model.PRDE01005841.1.1 Q9HZE0 DHE2_PSEAE 65.591 0.978723 0.0580247 gdhB - NAD-specific glutamate dehydrogenase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - gdhB gene Involved in arginine catabolism by converting L-glutamate, into 2-oxoglutarate, which is then channeled into the tricarboxylic acid cycle. Can also utilize other amino acids of the glutamate family. Indicus|evm.model.PRDE01005906.1.2 Q8RKT5 LIFO_PSEME 82.175 0.976331 1.00896 lifO - Lipase chaperone - Pseudomonas mendocina - lifO gene May be involved in the folding of the extracellular lipase during its passage through the periplasm. Indicus|evm.model.PRDE01005906.1.3 P26876 LIP_PSEAE 80.537 0.986486 0.475884 lip - Triacylglycerol lipase precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - lip gene Catalyzes the hydrolysis of triacylglycerol (PubMed:1748875). It also exhibits some esterase activity with p-nitrophenyl acetate and Tween 80 as substrates, however the lipase activity is approximately eight times the esterase activity (PubMed:1748875). It shows a marked specificity for the 1,3-oleyl residues of triolein (PubMed:1748875). Indicus|evm.model.PRDE01005929.1.1 A4VKE7 LEUC_PSEU5 100.000 0.988636 0.185263 leuC - 3-isopropylmalate dehydratase large subunit - Pseudomonas stutzeri (strain A1501) - leuC gene Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. Indicus|evm.model.PRDE01005929.1.2 P96194 YIBL_AZOVI 86.792 0.360825 2.02083 Uncharacterized HTH-type transcriptional regulator in ibpB-leuC intergenic region - Azotobacter vinelandii Indicus|evm.model.PRDE01005929.1.3 P96193 IBPB_AZOVI 75.000 0.959732 1.01361 ibpB - 16 kDa heat shock protein B - Azotobacter vinelandii - ibpB gene Indicus|evm.model.PRDE01005931.1.1 Q4P6X6 PPIH_USTMA 63.265 0.959184 0.942308 CYP3 - Peptidyl-prolyl cis-trans isomerase H - Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) - CYP3 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Indicus|evm.model.PRDE01006034.1.1 Q21276 NOP56_CAEEL 46.341 0.727273 1.01852 nol-56 - Nucleolar protein 56 - Caenorhabditis elegans - nol-56 gene Required for 60S ribosomal subunit synthesis. Indicus|evm.model.PRDE01006038.1.1 P60230 TRA1_MYCTU 77.419 0.677778 0.216867 Rv1199c - Transposase for insertion sequence element IS1081 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1199c gene Required for the transposition of the insertion element. Indicus|evm.model.PRDE01006038.1.2 P9WKH8 TRA9_MYCTO 53.012 0.710526 0.410072 MT1803 - Putative transposase for insertion sequence element IS986/IS6110 - Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) - MT1803 gene Involved in the transposition of the insertion sequence. Indicus|evm.model.PRDE01006092.1.1 Q92585 MAML1_HUMAN 87.834 0.997015 0.329724 MAML1 - Mastermind-like protein 1 - Homo sapiens (Human) - MAML1 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Indicus|evm.model.PRDE01006134.1.1 O18965 KCNH1_BOVIN 100.000 0.775956 0.18541 KCNH1 - Potassium voltage-gated channel subfamily H member 1 - Bos taurus (Bovine) - KCNH1 gene Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9524140). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity). Indicus|evm.model.PRDE01006142.1.1 A4VQZ0 SYL_PSEU5 93.860 0.991266 0.263825 leuS - Leucine--tRNA ligase - Pseudomonas stutzeri (strain A1501) - leuS gene Indicus|evm.model.PRDE01006168.1.1 P9WN33 ASNH_MYCTU 71.117 0.997268 0.56135 asnB - Putative asparagine synthetase [glutamine-hydrolyzing] - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - asnB gene cytosol, extracellular region, plasma membrane Indicus|evm.model.PRDE01006196.1.1 Q6F2E7 SOX9_XENTR 92.000 0.907407 0.112033 sox9 - Transcription factor Sox-9 - Xenopus tropicalis (Western clawed frog) - sox9 gene Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including COL2A1. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes. Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells. Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells (By similarity). Unlikely to play a role in sex determination but may function during testicular and ovarian differentiation (PubMed:18692165, PubMed:18816826). Indicus|evm.model.PRDE01006200.1.1 Q6PB70 ANO8_MOUSE 98.198 0.990991 0.104717 Ano8 - Anoctamin-8 - Mus musculus (Mouse) - Ano8 gene Does not exhibit calcium-activated chloride channel (CaCC) activity. Indicus|evm.model.PRDE01006210.1.2 A4VP32 ALLC_PSEU5 96.629 0.994382 0.537764 alc - Probable allantoicase - Pseudomonas stutzeri (strain A1501) - alc gene Indicus|evm.model.PRDE01006323.1.1 Q1QMM1 SYQ_NITHX 74.074 0.617284 0.145161 glnS - Glutamine--tRNA ligase - Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14) - glnS gene Indicus|evm.model.PRDE01006335.1.1 Q9I6G2 Y329_PSEAE 63.636 0.939655 1.05455 PA0329 - UPF0339 protein PA0329 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA0329 gene Indicus|evm.model.PRDE01006375.1.1 P25491 MAS5_YEAST 44.840 0.985507 0.674817 YDJ1 - Mitochondrial protein import protein MAS5 precursor - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - YDJ1 gene Probably involved in mitochondrial protein import. Is also required for efficient translocation of pre-pro-alpha-factor. Involved in heme regulation of HAP1, as a component of the high-molecular-weight (HMC) complex. Indicus|evm.model.PRDE01006380.1.1 P9WLT1 Y1708_MYCTU 76.433 0.975 0.503145 Rv1708 - Uncharacterized protein Rv1708 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1708 gene May play a role in septum formation. Indicus|evm.model.PRDE01006386.1.1 Q8NRN8 FUMC_CORGL 77.297 0.963351 0.403805 fumC - Fumarate hydratase class II - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - fumC gene Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate. Indicus|evm.model.PRDE01006386.1.2 Q6M6E7 GLPX_CORGL 69.565 0.849057 0.158209 glpX - Fructose-1,6-bisphosphatase class 2 - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - glpX gene Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Is essential for growth on gluconeogenic carbon sources. Also displays a low activity toward glucose 6-phosphate, and fructose 6-phosphate, glycerol 3-phosphate, ribulose 1,5-bisphosphate and myo-inositol-monophosphate are not significant substrates. Indicus|evm.model.PRDE01006388.1.1 G3XCX7 PILP_PSEAE 72.727 0.442368 1.84483 pilP - Type IV pilus inner membrane component PilP precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pilP gene Inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. PilN/PilO heterodimers form the foundation of the inner-membrane PilM/PilN/PilO/PilP complex which plays an essential role in the assembly of a functional T4 pilus (PubMed:19857645). PilP connects PilO to the secretin PilQ. In turn, the PilM/PilN/PilO/PilP/PilQ complex facilitates transit of the pilus through the periplasm and clamps the pilus in the cell envelope (PubMed:23457250). Indicus|evm.model.PRDE01006424.1.1 Q0P5L0 RBM42_BOVIN 57.547 0.502392 0.466518 RBM42 - RNA-binding protein 42 - Bos taurus (Bovine) - RBM42 gene Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. Indicus|evm.model.PRDE01006569.1.1 Q9QWN8 SPTN2_RAT 93.878 0.932692 0.0435511 Sptbn2 - Spectrin beta chain, non-erythrocytic 2 - Rattus norvegicus (Rat) - Sptbn2 gene Probably plays an important role in neuronal membrane skeleton. Indicus|evm.model.PRDE01006646.1.1 Q28824 MYLK_BOVIN 99.091 0.981982 0.0943878 MYLK - Myosin light chain kinase, smooth muscle - Bos taurus (Bovine) - MYLK gene Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells (By similarity). Indicus|evm.model.PRDE01006656.1.1 Q9N1R2 EAA4_CANLF 100.000 0.971014 0.12234 SLC1A6 - Excitatory amino acid transporter 4 - Canis lupus familiaris (Dog) - SLC1A6 gene Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Indicus|evm.model.PRDE01006706.1.1 Q13574 DGKZ_HUMAN 96.429 0.982301 0.121767 DGKZ - Diacylglycerol kinase zeta - Homo sapiens (Human) - DGKZ gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). Indicus|evm.model.PRDE01006716.1.1 Q9NRH2 SNRK_HUMAN 83.206 0.984848 0.172549 SNRK - SNF-related serine/threonine-protein kinase - Homo sapiens (Human) - SNRK gene May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. Indicus|evm.model.PRDE01006721.1.1 Q8NBH2 KY_HUMAN 86.066 0.991803 0.184569 KY - Kyphoscoliosis peptidase - Homo sapiens (Human) - KY gene Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity). Indicus|evm.model.PRDE01006791.1.1 P0AEP9 GLCD_ECOLI 81.162 0.996 1.002 glcD - Glycolate oxidase subunit GlcD - Escherichia coli (strain K12) - glcD gene Component of a complex that catalyzes the oxidation of glycolate to glyoxylate (PubMed:4557653, PubMed:8606183). Is required for E.coli to grow on glycolate as a sole source of carbon (PubMed:8606183). Is also able to oxidize D-lactate ((R)-lactate) with a similar rate (PubMed:4557653). Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown (PubMed:4557653). Indicus|evm.model.PRDE01006792.1.1 G0SEA3 GLE2_CHATD 46.970 0.474638 0.773109 GLE2 - Nucleoporin GLE2 - Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) - GLE2 gene Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically important for nuclear mRNA export. Indicus|evm.model.PRDE01006828.1.2 Q9I6Z0 OXODE_PSEAE 78.832 0.964539 0.314031 PA0142 - 8-oxoguanine deaminase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA0142 gene Specifically deaminates 8-Oxoguanine (8-oxoG) to uric acid. 8-oxoG is formed via the oxidation of guanine within DNA by reactive oxygen species and leads, if uncorrected, to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions. Indicus|evm.model.PRDE01006830.1.1 Q8ZNW0 KPYK2_SALTY 59.223 0.910714 0.233333 pykA - Pyruvate kinase II - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - pykA gene Catalyzes the formation of pyruvate in the last step of glycolysis, it is irreversible under physiological conditions. The reaction is critical for the control of metabolic flux in the second part of glycolysis. Indicus|evm.model.PRDE01006883.1.1 P52073 GLCE_ECOLI 57.576 0.723881 0.382857 glcE - Glycolate oxidase subunit GlcE - Escherichia coli (strain K12) - glcE gene Component of a complex that catalyzes the oxidation of glycolate to glyoxylate (PubMed:4557653, PubMed:8606183). Is required for E.coli to grow on glycolate as a sole source of carbon (PubMed:8606183). Is also able to oxidize D-lactate ((R)-lactate) with a similar rate (PubMed:4557653). Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown (PubMed:4557653). Indicus|evm.model.PRDE01006884.1.1 P52073 GLCE_ECOLI 59.292 0.941176 0.34 glcE - Glycolate oxidase subunit GlcE - Escherichia coli (strain K12) - glcE gene Component of a complex that catalyzes the oxidation of glycolate to glyoxylate (PubMed:4557653, PubMed:8606183). Is required for E.coli to grow on glycolate as a sole source of carbon (PubMed:8606183). Is also able to oxidize D-lactate ((R)-lactate) with a similar rate (PubMed:4557653). Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown (PubMed:4557653). Indicus|evm.model.PRDE01006940.1.1 Q13488 VPP3_HUMAN 92.754 0.985507 0.0831325 TCIRG1 - V-type proton ATPase 116 kDa subunit a3 - Homo sapiens (Human) - TCIRG1 gene Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. Indicus|evm.model.PRDE01006973.1.1 P60230 TRA1_MYCTU 70.098 0.995098 0.491566 Rv1199c - Transposase for insertion sequence element IS1081 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1199c gene Required for the transposition of the insertion element. Indicus|evm.model.PRDE01006987.1.1 Q9H0E9 BRD8_HUMAN 94.828 0.982759 0.0469636 BRD8 - Bromodomain-containing protein 8 - Homo sapiens (Human) - BRD8 gene May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Indicus|evm.model.PRDE01006994.1.1 P0AAZ4 RARA_ECOLI 60.870 0.991228 0.255034 rarA - Replication-associated recombination protein A - Escherichia coli (strain K12) - rarA gene DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. Indicus|evm.model.PRDE01007019.1.1 Q9ZVJ4 CYP22_ARATH 56.311 0.971429 0.527638 CYP22 - Peptidyl-prolyl cis-trans isomerase CYP22 - Arabidopsis thaliana (Mouse-ear cress) - CYP22 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Indicus|evm.model.PRDE01007174.1.1 A4VKA3 FADB_PSEU5 98.161 0.92846 0.899301 fadB - Fatty acid oxidation complex subunit alpha - Pseudomonas stutzeri (strain A1501) - fadB gene Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. Indicus|evm.model.PRDE01007225.1.1 Q6IF82 O4A47_HUMAN 70.312 0.954545 0.213592 OR4A47 - Olfactory receptor 4A47 - Homo sapiens (Human) - OR4A47 gene Odorant receptor. Indicus|evm.model.PRDE01007239.1.1 P29933 COBS_SINSX 83.654 0.990385 0.313253 cobS - Aerobic cobaltochelatase subunit CobS - Sinorhizobium sp. - cobS gene Catalyzes cobalt insertion in the corrin ring. Indicus|evm.model.PRDE01007240.1.1 Q9P281 BAHC1_HUMAN 86.275 0.980392 0.0193255 BAHCC1 - BAH and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - BAHCC1 gene Indicus|evm.model.PRDE01007262.1.1 O59010 GLT_PYRHO 44.275 0.911111 0.317647 PH1295 - Glutamate transporter homolog - Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) - PH1295 gene Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583). Indicus|evm.model.PRDE01007295.1.1 Q6M0B4 WECBH_METMP 57.282 0.953271 0.29972 MMP0357 - UDP-N-acetylglucosamine 2-epimerase homolog - Methanococcus maripaludis (strain S2 / LL) - MMP0357 gene Indicus|evm.model.PRDE01007310.1.3 P72332 NODG_RHIS3 45.238 0.0580326 5.76735 nodG - Nodulation protein G - Rhizobium sp. (strain N33) - nodG gene Proposed to modify Nod factor fatty acyl chain. Indicus|evm.model.PRDE01007345.1.1 P62914 RL11_RAT 85.586 0.982143 0.629213 Rpl11 - 60S ribosomal protein L11 - Rattus norvegicus (Rat) - Rpl11 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Promotes nucleolar location of PML. Indicus|evm.model.PRDE01007388.1.1 A0QSK6 RMLB_MYCS2 60.630 0.992126 0.383686 rmlB - dTDP-glucose 4,6-dehydratase - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - rmlB gene Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction (By similarity). Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage (PubMed:16472764). Indicus|evm.model.PRDE01007400.1.1 A4VQH4 RUTA_PSEU5 96.736 0.994083 0.938889 rutA - Pyrimidine monooxygenase RutA - Pseudomonas stutzeri (strain A1501) - rutA gene Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide. The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN. Requires the flavin reductase RutF to regenerate FMN in vivo. Indicus|evm.model.PRDE01007549.1.1 Q8NCJ5 SPRY3_HUMAN 95.946 0.986486 0.167421 SPRYD3 - SPRY domain-containing protein 3 - Homo sapiens (Human) - SPRYD3 gene cytoplasm, cell surface receptor signaling pathway, cytoskeleton organization Indicus|evm.model.PRDE01007562.1.1 Q6NJ64 RS4_CORDI 83.582 0.990099 1.00498 rpsD - 30S ribosomal protein S4 - Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) - rpsD gene One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. Indicus|evm.model.PRDE01007569.1.1 P48681 NEST_HUMAN 92.135 0.953405 0.172116 NES - Nestin - Homo sapiens (Human) - NES gene Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Indicus|evm.model.PRDE01007714.1.1 B2GGB4 TIG_KOCRD 75.610 0.72973 0.247768 tig - Trigger factor - Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201) - tig gene Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Indicus|evm.model.PRDE01007746.1.1 Q9HZE0 DHE2_PSEAE 66.292 0.988764 0.0549383 gdhB - NAD-specific glutamate dehydrogenase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - gdhB gene Involved in arginine catabolism by converting L-glutamate, into 2-oxoglutarate, which is then channeled into the tricarboxylic acid cycle. Can also utilize other amino acids of the glutamate family. Indicus|evm.model.PRDE01007769.1.1 A4VQP2 MUTL_PSEU5 98.720 0.996805 1.0016 mutL - DNA mismatch repair protein MutL - Pseudomonas stutzeri (strain A1501) - mutL gene This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. Indicus|evm.model.PRDE01007771.1.1 Q1LJ80 ATR_CUPMC 51.634 0.980519 0.836957 cobO - Cobalamin adenosyltransferase - Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) - cobO gene Adenosyltransferase that catalyzes the conversion of cob(II)alamin to adenosylcob(III)alamin (AdoCbl) in the presence of ATP and an electron donor. Acts as an accessory protein of IcmF that functions in cofactor repair, since IcmF is prone to inactivation during catalytic turnover due to the occasional loss of the 5'-deoxyadenosine moiety and formation of the inactive cob(II)alamin cofactor in its active site. Thus, receives and repairs the inactive cofactor, which is then reloaded onto IcmF in a GTPase-gated step. Indicus|evm.model.PRDE01007789.1.2 P19319 NARZ_ECOLI 69.841 0.984127 0.0505618 narZ - Respiratory nitrate reductase 2 alpha chain - Escherichia coli (strain K12) - narZ gene This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. Indicus|evm.model.PRDE01007805.1.1 P20753 PPIA_SALTY 69.136 0.87027 0.973684 ppiA - Peptidyl-prolyl cis-trans isomerase A precursor - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - ppiA gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Indicus|evm.model.PRDE01007865.1.1 Q9HTZ7 PCKA_PSEAE 91.469 0.990566 0.413255 pckA - Phosphoenolpyruvate carboxykinase (ATP) - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pckA gene Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Indicus|evm.model.PRDE01007865.1.2 Q55233 DRGA_SYNY3 49.000 0.965174 0.957143 drgA - Protein DrgA - Synechocystis sp. (strain PCC 6803 / Kazusa) - drgA gene Controls resistance to the herbicide Dinoseb and metronidazole. Involved in detoxification of Dinoseb via the reduction of the nitro group(s) and this process is accompanied by the formation of toxic superoxide anions. Indicus|evm.model.PRDE01007892.1.1 Q03320 ARACL_STRAT 48.387 0.91 0.330033 Putative AraC-like transcription regulator - Streptomyces antibioticus Indicus|evm.model.PRDE01007892.1.2 P32176 FDOG_ECOLI 66.286 0.983051 0.174213 fdoG - Formate dehydrogenase-O major subunit precursor - Escherichia coli (strain K12) - fdoG gene Allows to use formate as major electron donor during aerobic respiration. Subunit alpha possibly forms the active site. Indicus|evm.model.PRDE01007910.1.2 P54409 TCPH_TETPY 56.798 0.956395 0.616487 T-complex protein 1 subunit eta - Tetrahymena pyriformis Indicus|evm.model.PRDE01007999.1.1 Q8C754 VPS52_MOUSE 94.444 0.609195 0.120332 Vps52 - Vacuolar protein sorting-associated protein 52 homolog - Mus musculus (Mouse) - Vps52 gene Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Indicus|evm.model.PRDE01008030.1.1 P08069 IGF1R_HUMAN 94.783 0.982759 0.0848574 IGF1R - Insulin-like growth factor 1 receptor precursor - Homo sapiens (Human) - IGF1R gene Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R. Indicus|evm.model.PRDE01008060.1.1 P40282 H2A_PLAFA 79.675 0.953125 0.969697 Histone H2A - Plasmodium falciparum Indicus|evm.model.PRDE01008087.1.1 Q11NN8 LEUC_CYTH3 61.250 0.929412 0.182403 leuC - 3-isopropylmalate dehydratase large subunit - Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465) - leuC gene Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. Indicus|evm.model.PRDE01008121.1.1 P82887 H2B_OLILU 75.556 0.824074 0.947368 Histone H2B - Olisthodiscus luteus (Marine phytoflagellate) Indicus|evm.model.PRDE01008169.1.1 C1B011 RS10_RHOOB 99.010 0.877193 1.12871 rpsJ - 30S ribosomal protein S10 - Rhodococcus opacus (strain B4) - rpsJ gene Involved in the binding of tRNA to the ribosomes. Indicus|evm.model.PRDE01008195.1.1 A4T1P7 RL7_MYCGI 80.000 0.984733 1.00769 rplL - 50S ribosomal protein L7/L12 - Mycolicibacterium gilvum (strain PYR-GCK) - rplL gene Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation. Indicus|evm.model.PRDE01008265.1.3 P0C7L2 PAAJ_ECOLI 57.960 0.995012 1 paaJ - 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase - Escherichia coli (strain K12) - paaJ gene Catalyzes the thiolytic cleavage of the beta-keto C8 intermediate 3-oxo-5,6-dehydrosuberyl-CoA with CoA to yield the C6 intermediate 2,3-dehydroadipyl-CoA and acetyl-CoA. Besides it catalyzes also the last step of the pathway, in which 3-oxoadipyl-CoA similarly is cleaved to acetyl-CoA and succinyl-CoA. Indicus|evm.model.PRDE01008265.1.5 Q52995 ECHH_RHIME 47.521 0.919847 1.01946 fadB1 - Probable enoyl-CoA hydratase - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - fadB1 gene Could possibly oxidize fatty acids using specific components. Indicus|evm.model.PRDE01008273.1.1 P47204 FTSZ_PSEAE 86.027 0.994521 0.926396 ftsZ - Cell division protein FtsZ - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - ftsZ gene Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. Indicus|evm.model.PRDE01008273.1.2 P47203 FTSA_PSEAE 89.437 0.992933 0.678657 ftsA - Cell division protein FtsA - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - ftsA gene Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Indicus|evm.model.PRDE01008293.1.1 P9WPQ3 ACCA1_MYCTU 64.493 0.985612 0.212538 accA1 - Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase alpha1 subunit - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - accA1 gene Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, resulting in the formation of carboxyl biotin (PubMed:25695631). When associated with the beta1 subunit AccD1, is involved in branched amino-acid catabolism with methylcrotonyl coenzyme A as the substrate (PubMed:25695631). Indicus|evm.model.PRDE01008338.1.1 B1J2R4 OPGH_PSEPW 70.040 0.853518 1.01167 opgH - Glucans biosynthesis glucosyltransferase H - Pseudomonas putida (strain W619) - opgH gene Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). Indicus|evm.model.PRDE01008351.1.1 Q9ZAA1 ACLDH_PSEAI 87.560 0.990476 0.41502 exaC - Acetaldehyde dehydrogenase - Pseudomonas aeruginosa - exaC gene Catalyzes the NAD(+)-dependent oxidation of acetaldehyde to acetate. Is likely a component of the ethanol oxidation system that allows P.aeruginosa to grow on ethanol as the sole carbon and energy source. Indicus|evm.model.PRDE01008413.1.1 Q9UKP4 ATS7_HUMAN 90.598 0.655367 0.104982 ADAMTS7 - A disintegrin and metalloproteinase with thrombospondin motifs 7 precursor - Homo sapiens (Human) - ADAMTS7 gene Metalloprotease that may play a role in the degradation of COMP. Indicus|evm.model.PRDE01008471.1.1 P9WH43 RS1_MYCTU 80.513 0.979798 0.411642 rpsA - 30S ribosomal protein S1 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - rpsA gene Binds mRNA, facilitating recognition of most mRNAs by the 30S ribosomal subunit during translation initiation (By similarity). Probably plays a role in trans-translation; binds tmRNA (the product of the ssrA gene) (PubMed:21835980). In trans-translation Ala-aminoacylated transfer-messenger RNA (tmRNA, product of the ssrA gene; the 2 termini fold to resemble tRNA(Ala) while it encodes a short internal open reading frame (the tag peptide)) acts like a tRNA, entering the A-site of the ribosome and displacing the stalled mRNA (which is subsequently degraded). The ribosome then switches to translate the ORF on the tmRNA, the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and thus targeted for degradation (By similarity). Indicus|evm.model.PRDE01008508.1.1 Q4K9S1 SYC_PSEF5 76.471 0.235714 0.304348 cysS - Cysteine--tRNA ligase - Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) - cysS gene Indicus|evm.model.PRDE01008509.1.1 Q5R8D8 DNJC7_PONAB 97.802 0.989011 0.184211 DNAJC7 - DnaJ homolog subfamily C member 7 - Pongo abelii (Sumatran orangutan) - DNAJC7 gene Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). Indicus|evm.model.PRDE01008548.1.1 Q5EAC6 CDC37_BOVIN 98.039 0.740876 0.721053 CDC37 - Hsp90 co-chaperone Cdc37 - Bos taurus (Bovine) - CDC37 gene Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity. Indicus|evm.model.PRDE01008602.1.1 Q24320 RPAB2_DROME 45.217 0.765101 1.1374 RpII18 - DNA-directed RNA polymerases I, II, and III subunit RPABC2 - Drosophila melanogaster (Fruit fly) - RpII18 gene DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). Indicus|evm.model.PRDE01008659.1.2 A4VMF7 IHFB_PSEU5 97.849 0.968421 1.02151 ihfB - Integration host factor subunit beta - Pseudomonas stutzeri (strain A1501) - ihfB gene This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Indicus|evm.model.PRDE01008660.1.1 P22105 TENX_HUMAN 81.159 0.913333 0.035344 TNXB - Tenascin-X precursor - Homo sapiens (Human) - TNXB gene Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. Indicus|evm.model.PRDE01008681.1.2 A4VQH7 RUTD_PSEU5 98.901 0.978261 0.34717 rutD - Putative aminoacrylate hydrolase RutD - Pseudomonas stutzeri (strain A1501) - rutD gene May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Indicus|evm.model.PRDE01008717.1.1 P49736 MCM2_HUMAN 99.083 0.624277 0.191372 MCM2 - DNA replication licensing factor MCM2 - Homo sapiens (Human) - MCM2 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis. Indicus|evm.model.PRDE01008729.1.1 Q0S1P3 MIAB_RHOJR 72.932 0.885906 0.29505 miaB - tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase - Rhodococcus jostii (strain RHA1) - miaB gene Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. Indicus|evm.model.PRDE01008757.1.1 O18404 HCD2_DROME 59.836 0.945312 0.501961 scu - 3-hydroxyacyl-CoA dehydrogenase type-2 - Drosophila melanogaster (Fruit fly) - scu gene May function in mitochondrial tRNA maturation. Catalyzes the beta-oxidation at position 17 of androgens and estrogens, and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-beta-hydroxylated bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. Required for cell survival during embryonic development. May play a role in germline formation. Indicus|evm.model.PRDE01008770.1.1 P0ADX9 RSMD_ECOLI 50.276 0.962567 0.944444 rsmD - Ribosomal RNA small subunit methyltransferase D - Escherichia coli (strain K12) - rsmD gene Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle. Indicus|evm.model.PRDE01008803.1.1 Q47282 T1ME_ECOLX 69.231 0.997664 0.873469 hsdM - Type I restriction enzyme EcoEI M protein - Escherichia coli - hsdM gene The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. The EcoEI enzyme recognizes 5'-GAGN(7)ATGC-3'. Indicus|evm.model.PRDE01008843.1.1 Q6NHP1 LYSE_CORDI 70.588 0.704225 0.311404 lysE - Lysine exporter LysE - Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) - lysE gene Catalyzes the efflux of L-lysine. Indicus|evm.model.PRDE01008846.1.1 Q8IT98 RS18_ARGIR 67.105 0.974194 1.01974 RPS18 - 40S ribosomal protein S18 - Argopecten irradians (Bay scallop) - RPS18 gene Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. Indicus|evm.model.PRDE01008873.1.2 Q45FF9 NACA_BABDI 48.000 0.900498 1.0203 Nascent polypeptide-associated complex subunit alpha - Babesia divergens Indicus|evm.model.PRDE01009000.1.1 A4VFG6 SYGB_PSEU5 96.532 0.99422 0.252924 glyS - Glycine--tRNA ligase beta subunit - Pseudomonas stutzeri (strain A1501) - glyS gene Indicus|evm.model.PRDE01009032.1.1 Q26671 CDC2H_THEAN 92.913 0.953307 0.862416 CRK2 - Cell division control protein 2 homolog - Theileria annulata - CRK2 gene Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). Indicus|evm.model.PRDE01009043.1.1 O08574 MESP2_MOUSE 75.200 0.478599 0.694595 Mesp2 - Mesoderm posterior protein 2 - Mus musculus (Mouse) - Mesp2 gene Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. May play a role with Tcf15 in the differentiation of myotomal and sclerotomal cells by regulating Pax family genes. Controls also the expression of the protocadherin PCDH8/PAPC, EPHA4, RIPPLY2, NOTCH2, FGFR1, and CER1. Binds to the E-boxes within the EPH4A and RIPPLY2 enhancers. Indicus|evm.model.PRDE01009145.1.1 A3Q3N5 KGD_MYCSJ 72.434 0.997059 0.268987 kgd - Multifunctional 2-oxoglutarate metabolism enzyme - Mycobacterium sp. (strain JLS) - kgd gene Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which spontaneously decarboxylates to form 5-hydroxylevulinate (HLA). And is also a component of the 2-oxoglutarate dehydrogenase (ODH) complex, that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The KG decarboxylase and KG dehydrogenase reactions provide two alternative, tightly regulated, pathways connecting the oxidative and reductive branches of the TCA cycle (By similarity). Indicus|evm.model.PRDE01009201.1.1 A0R574 CLPC1_MYCS2 90.547 0.995025 0.237028 clpC1 - ATP-dependent Clp protease ATP-binding subunit ClpC1 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - clpC1 gene ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable). Indicus|evm.model.PRDE01009248.1.1 Q9BVG9 PTSS2_HUMAN 96.591 0.925532 0.193018 PTDSS2 - Phosphatidylserine synthase 2 - Homo sapiens (Human) - PTDSS2 gene Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:19014349). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity). Indicus|evm.model.PRDE01009263.1.1 Q8TER0 SNED1_HUMAN 92.727 0.477876 0.0799717 SNED1 - Sushi, nidogen and EGF-like domain-containing protein 1 precursor - Homo sapiens (Human) - SNED1 gene Notch binding Indicus|evm.model.PRDE01009294.1.1 P40639 AES4_ALLMI 100.000 0.474227 1.34722 SRY-related protein AES4 - Alligator mississippiensis (American alligator) Indicus|evm.model.PRDE01009295.1.1 P9WGJ1 Y3661_MYCTU 54.634 0.89083 0.797909 Rv3661 - Probable phosphatase Rv3661 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv3661 gene cytosol Indicus|evm.model.PRDE01009318.1.1 B4U739 RS12_HYDS0 59.615 0.556757 1.37037 rpsL - 30S ribosomal protein S12 - Hydrogenobaculum sp. (strain Y04AAS1) - rpsL gene With S4 and S5 plays an important role in translational accuracy. Indicus|evm.model.PRDE01009353.1.1 O08664 BCL7C_MOUSE 100.000 0.982456 0.262673 Bcl7c - B-cell CLL/lymphoma 7 protein family member C - Mus musculus (Mouse) - Bcl7c gene May play an anti-apoptotic role. Indicus|evm.model.PRDE01009381.1.1 Q86Z23 C1QL4_HUMAN 98.324 0.994413 0.752101 C1QL4 - Complement C1q-like protein 4 precursor - Homo sapiens (Human) - C1QL4 gene May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity). Indicus|evm.model.PRDE01009425.1.1 P05444 CLPA_RHOBL 84.685 0.982143 0.141236 ClpA homolog protein - Rhodobacter blasticus Indicus|evm.model.PRDE01009464.1.1 Q25563 TBA13_NAEPR 76.984 0.984252 0.280353 TUBA13 - Tubulin alpha-13 chain - Naegleria pringsheimi (Amoeba) - TUBA13 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Indicus|evm.model.PRDE01009485.1.1 Q0WPU1 MYO15_ARATH 59.184 0.75 0.0420499 XI-I - Myosin-15 - Arabidopsis thaliana (Mouse-ear cress) - XI-I gene Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Involved in trafficking of Golgi stacks and mitochondria. Plays a role in nuclear shape determination. Drives nuclear movement along actin filaments (PubMed:23973298). As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PubMed:25759303). Indicus|evm.model.PRDE01009517.1.1 Q5RKV6 EXOS6_HUMAN 91.765 0.857143 0.360294 EXOSC6 - Exosome complex component MTR3 - Homo sapiens (Human) - EXOSC6 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Indicus|evm.model.PRDE01009535.1.1 Q16798 MAON_HUMAN 94.286 0.985714 0.115894 ME3 - NADP-dependent malic enzyme, mitochondrial precursor - Homo sapiens (Human) - ME3 gene mitochondrial matrix, mitochondrion, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, NADP+ binding, aerobic respiration, malate metabolic process, oxygen metabolic process, pyruvate metabolic process, tricarboxylic acid cycle Indicus|evm.model.PRDE01009538.1.1 O02755 CEBPB_BOVIN 97.126 0.994269 1.00287 CEBPB - CCAAT/enhancer-binding protein beta - Bos taurus (Bovine) - CEBPB gene Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing. During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation. Essential for female reproduction because of a critical role in ovarian follicle development. Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). Indicus|evm.model.PRDE01009570.1.1 Q3KQ23 UBA5_XENLA 60.268 0.568475 0.974811 uba5 - Ubiquitin-like modifier-activating enzyme 5 - Xenopus laevis (African clawed frog) - uba5 gene E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates ufm1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ufm1-E1 thioester and free AMP. Activates ufm1 via a trans-binding mechanism, in which ufm1 interacts with distinct sites in both subunits of the uba5 homodimer. Trans-binding also promotes stabilization of the uba5 homodimer, and enhances ATP-binding. Transfer of ufm1 from uba5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Indicus|evm.model.PRDE01009599.1.1 O14232 MTR4_SCHPO 58.093 0.853801 0.459266 mtr4 - ATP-dependent RNA helicase mtr4 - Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) - mtr4 gene Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates (By similarity). Required for heterochromatic gene silencing at centromeric repeats by either exosome- or RNAi-mediated degradation of heterochromatic transcripts. Indicus|evm.model.PRDE01009631.1.1 Q8R116 NOTUM_MOUSE 89.565 0.909091 0.240557 Notum - Palmitoleoyl-protein carboxylesterase NOTUM precursor - Mus musculus (Mouse) - Notum gene Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Indicus|evm.model.PRDE01009689.1.1 Q8NVS5 SDCS_STAAW 50.388 0.587156 0.419231 sdcS - Sodium-dependent dicarboxylate transporter SdcS - Staphylococcus aureus (strain MW2) - sdcS gene Mediates the transport of the dicarboxylates fumarate, malate, and succinate across the cytoplasmic membrane via a Na(+)-electrochemical gradient. Indicus|evm.model.PRDE01009838.1.1 P36411 RAB7A_DICDI 63.636 0.986207 0.714286 rab7A - Ras-related protein Rab-7a - Dictyostelium discoideum (Slime mold) - rab7A gene Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Involved in lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Indicus|evm.model.PRDE01009913.1.1 Q8NGK0 O51G2_HUMAN 65.041 0.890511 0.436306 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Indicus|evm.model.PRDE01010095.1.2 P29267 HOXA_CUPNH 45.277 0.54479 1.13485 hoxA - Hydrogenase transcriptional regulatory protein HoxA - Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) - hoxA gene Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be HoxX) and then acts in conjunction with sigma-54 as a transcriptional activator. Indicus|evm.model.PRDE01010102.1.1 Q5ZHT1 ACD11_CHICK 56.686 0.997067 0.438867 ACAD11 - Acyl-CoA dehydrogenase family member 11 - Gallus gallus (Chicken) - ACAD11 gene Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain. Indicus|evm.model.PRDE01010117.1.1 P9WFZ1 TRMI_MYCTU 68.293 0.985366 0.732143 trmI - tRNA (adenine(58)-N(1))-methyltransferase TrmI - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - trmI gene Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. Indicus|evm.model.PRDE01010128.1.1 Q9UFP1 GAK1A_HUMAN 68.358 0.907104 0.636522 GASK1A - Golgi-associated kinase 1A precursor - Homo sapiens (Human) - GASK1A gene endoplasmic reticulum, extracellular region, Golgi apparatus, intracellular membrane-bounded organelle Indicus|evm.model.PRDE01010154.1.2 P25524 CODA_ECOLI 59.091 0.977528 0.208431 codA - Cytosine deaminase - Escherichia coli (strain K12) - codA gene Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5-fluorocytosine (5FC) to 5-fluorouracil (5FU); this activity allows the formation of a cytotoxic chemotherapeutic agent from a non-cytotoxic precursor. Indicus|evm.model.PRDE01010264.1.1 Q86VR8 FJX1_HUMAN 89.007 0.996454 0.645309 FJX1 - Four-jointed box protein 1 precursor - Homo sapiens (Human) - FJX1 gene Acts as an inhibitor of dendrite extension and branching. Indicus|evm.model.PRDE01010376.1.1 Q02PG5 GAP2_PSEAB 54.082 0.989362 0.203905 gap2 - Glyceraldehyde-3-phosphate dehydrogenase-like protein - Pseudomonas aeruginosa (strain UCBPP-PA14) - gap2 gene Indicus|evm.model.PRDE01010401.1.1 P55270 SCNNA_BOVIN 100.000 0.969697 0.101538 SCNN1A - Amiloride-sensitive sodium channel subunit alpha - Bos taurus (Bovine) - SCNN1A gene Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Indicus|evm.model.PRDE01010414.1.2 P9WKJ1 CYSQ_MYCTU 50.467 0.646259 0.550562 cysQ - 3'-phosphoadenosine 5'-phosphate phosphatase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - cysQ gene Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I-1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F-6-P)) and AMP in vitro, but this might not be significant in vivo. Glucose-1-phosphate (G-1-P), p-nitrophenyl phosphate (pNPP), and beta-glycerol phosphate (beta-GP) are also good substrates, compared to I-1-P. With much lower efficiency, can also hydrolyze inositol 2-phosphate (I-2-P) and glucose-6-phosphate (G-6-P) in vitro, but not fructose-6-phosphate (F-6-P) and trehalose-6-phosphate (T-6-P). Indicus|evm.model.PRDE01010533.1.1 Q7KUT2 LONM_DROME 56.954 0.78534 0.186523 Lon - Lon protease homolog, mitochondrial precursor - Drosophila melanogaster (Fruit fly) - Lon gene ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Regulates mitochondrial DNA (mtDNA) copy number and transcription by stabilizing the mitochondrial TFAM:mtDNA ratio via selective degradation of TFAM. Indicus|evm.model.PRDE01010556.1.1 Q10571 MN1_HUMAN 92.760 0.964912 0.345455 MN1 - Transcriptional activator MN1 - Homo sapiens (Human) - MN1 gene Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). Indicus|evm.model.PRDE01010564.1.1 Q8MJV2 NPBW2_BOVIN 99.617 0.992366 0.779762 NPBWR2 - Neuropeptides B/W receptor type 2 - Bos taurus (Bovine) - NPBWR2 gene Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity). Indicus|evm.model.PRDE01010619.1.1 Q6ZNJ1 NBEL2_HUMAN 99.043 0.928571 0.0813362 NBEAL2 - Neurobeachin-like protein 2 - Homo sapiens (Human) - NBEAL2 gene Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. Indicus|evm.model.PRDE01010629.1.1 Q51455 CHEY_PSEAE 96.774 0.984 1.00806 cheY - Chemotaxis protein CheY - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - cheY gene Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation. Indicus|evm.model.PRDE01010633.1.1 P19906 NTRB_VIBAL 49.148 0.972299 1.03143 ntrB - Sensory histidine kinase/phosphatase NtrB - Vibrio alginolyticus - ntrB gene Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC. Indicus|evm.model.PRDE01010644.1.3 Q9FB58 UPPP_CORST 73.529 0.912162 0.52669 uppP - Undecaprenyl-diphosphatase - Corynebacterium striatum - uppP gene Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity). Indicus|evm.model.PRDE01010708.1.1 Q8N7J2 AMER2_HUMAN 76.699 0.993506 0.459016 AMER2 - APC membrane recruitment protein 2 - Homo sapiens (Human) - AMER2 gene Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Indicus|evm.model.PRDE01010717.1.1 P37351 RPIB_ECOLI 54.795 0.972973 0.496644 rpiB - Ribose-5-phosphate isomerase B - Escherichia coli (strain K12) - rpiB gene Catalyzes the interconversion of ribulose-5-P and ribose-5-P. It probably also has activity on D-allose 6-phosphate. Indicus|evm.model.PRDE01010759.1.1 Q8N7X2 STPG3_HUMAN 60.075 0.992395 0.681347 STPG3 - Protein STPG3 - Homo sapiens (Human) - STPG3 gene cytoskeleton Indicus|evm.model.PRDE01010784.1.1 Q5E985 HYAL1_BOVIN 98.951 0.989583 0.64 HYAL1 - Hyaluronidase-1 precursor - Bos taurus (Bovine) - HYAL1 gene May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Indicus|evm.model.PRDE01010865.1.1 P0ACZ8 CUSR_ECOLI 50.000 0.931373 0.449339 cusR - Transcriptional regulatory protein CusR - Escherichia coli (strain K12) - cusR gene Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Activates the expression of cusCFBA, hiuH and plasmid pRJ1004 gene pcoE in response to increasing levels of copper or silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD. Indicus|evm.model.PRDE01011053.1.1 P9WJ01 Y480_MYCTU 54.822 0.923445 0.746429 Rv0480c - Hydrolase Rv0480c - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv0480c gene cell wall Indicus|evm.model.PRDE01011055.1.1 Q9D8X5 CNOT8_MOUSE 51.373 0.67655 1.27055 Cnot8 - CCR4-NOT transcription complex subunit 8 - Mus musculus (Mouse) - Cnot8 gene Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. Indicus|evm.model.PRDE01011111.1.1 P41001 TOP2_PLAFK 50.996 0.65427 0.519313 TOP2 - DNA topoisomerase 2 - Plasmodium falciparum (isolate K1 / Thailand) - TOP2 gene Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indicus|evm.model.PRDE01011137.1.1 Q9HC84 MUC5B_HUMAN 59.140 0.978723 0.0163138 MUC5B - Mucin-5B precursor - Homo sapiens (Human) - MUC5B gene Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Indicus|evm.model.PRDE01011198.1.1 A4VFH7 FMT_PSEU5 94.323 0.991304 0.732484 fmt - Methionyl-tRNA formyltransferase - Pseudomonas stutzeri (strain A1501) - fmt gene Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. Indicus|evm.model.PRDE01011273.1.1 P97526 NF1_RAT 100.000 0.993056 0.0510638 Nf1 - Neurofibromin - Rattus norvegicus (Rat) - Nf1 gene Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity (By similarity). Indicus|evm.model.PRDE01011309.1.1 P60230 TRA1_MYCTU 48.611 0.763441 0.224096 Rv1199c - Transposase for insertion sequence element IS1081 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1199c gene Required for the transposition of the insertion element. Indicus|evm.model.PRDE01011466.1.1 P10343 YI42_PSEAY 67.722 0.957317 0.414141 Uncharacterized 42.6 kDa protein in isoamylase 3'region - Pseudomonas amyloderamosa Indicus|evm.model.PRDE01011483.1.1 Q8NBI6 XXLT1_HUMAN 97.619 0.994048 0.427481 XXYLT1 - Xyloside xylosyltransferase 1 - Homo sapiens (Human) - XXYLT1 gene Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869). Indicus|evm.model.PRDE01011532.1.1 P13567 UVRA_MICLU 90.566 0.411306 0.517137 uvrA - UvrABC system protein A - Micrococcus luteus - uvrA gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Indicus|evm.model.PRDE01011532.1.2 P9WQK7 UVRA_MYCTU 63.223 0.995816 0.245885 uvrA - UvrABC system protein A - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - uvrA gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Alone it slightly inhibits RecA-mediated DNA strand exchange, in concert with UvrD1 greatly inhibits RecA-mediated DNA strand exchange. Indicus|evm.model.PRDE01011611.1.2 Q7RJG2 CDPK4_PLAYO 50.820 0.952381 0.357955 CDPK4 - Calcium-dependent protein kinase 4 - Plasmodium yoelii yoelii - CDPK4 gene Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase. Plays a central role in the host erythrocytes and hepatocytes infection cycles, sexual reproduction and mosquito transmission of the parasite. During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK1 and CDPK5. Involved in merosome egress from host hepatocytes, probably together with CDPK5. During the asexual blood stage, involved in merozoite invasion of host erythrocytes and motility by stabilizing the inner membrane complex, a structure below the plasma membrane which acts as an anchor for the glidosome, an acto-myosin motor. Required for cell cycle progression in the male gametocyte. During male gametogenesis in the mosquito gut, required to initiate the first round of DNA replication, probably by facilitating the assembly of the pre-replicative MCM complex, to assemble the first mitotic spindle and, at the end of gametogenesis, to initiate axoneme motility, cytokinesis and subsequent exflagellation. For each of these steps, may phosphorylate SOC1, SOC2 and SOC3, respectively. Together with CDPK1, regulates ookinete gliding in the mosquito host midgut. Indicus|evm.model.PRDE01011687.1.1 Q6C0I0 SNU13_YARLI 73.832 0.946429 0.888889 SNU13 - 13 kDa ribonucleoprotein-associated protein - Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) - SNU13 gene Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity). Indicus|evm.model.PRDE01011687.1.2 A9PDZ7 METK2_POPTR 57.289 0.933842 1 METK2 - S-adenosylmethionine synthase 2 - Populus trichocarpa (Western balsam poplar) - METK2 gene Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Indicus|evm.model.PRDE01011786.1.1 Q8IED2 SMC2_PLAF7 49.032 0.434659 0.288998 MAL13P1.96 - Structural maintenance of chromosomes protein 2 - Plasmodium falciparum (isolate 3D7) - MAL13P1.96 gene May play a role in the conversion of interphase chromatin into condensed chromosomes. Indicus|evm.model.PRDE01011841.1.1 P0ACL5 GLCC_ECOLI 64.167 0.959677 0.488189 glcC - Glc operon transcriptional activator - Escherichia coli (strain K12) - glcC gene Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity (PubMed:8606183, PubMed:9880556). Also negatively regulates the transcription of its own gene (PubMed:9880556). Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector (PubMed:9880556). Indicus|evm.model.PRDE01011841.1.2 Q3K4G4 UBIC2_PSEPF 64.583 0.626667 0.409836 ubiC2 - Probable chorismate pyruvate-lyase 2 - Pseudomonas fluorescens (strain Pf0-1) - ubiC2 gene Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway. Indicus|evm.model.PRDE01011926.1.1 Q8R3C6 RBM19_MOUSE 97.015 0.733333 0.0945378 Rbm19 - Probable RNA-binding protein 19 - Mus musculus (Mouse) - Rbm19 gene Plays a role in embryo pre-implantation development. Indicus|evm.model.PRDE01011987.1.2 Q8FP75 RRF_COREF 72.432 0.989247 1.00541 frr - Ribosome-recycling factor - Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) - frr gene Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. Indicus|evm.model.PRDE01012007.1.1 Q55BV5 PRS4_DICDI 74.809 0.977444 0.302961 psmC1 - 26S proteasome regulatory subunit 4 homolog - Dictyostelium discoideum (Slime mold) - psmC1 gene The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Plays an important role in regulating both growth and multicellular development. Indicus|evm.model.PRDE01012045.1.1 P9WHQ7 PUR1_MYCTU 60.714 0.733333 0.142315 purF - Amidophosphoribosyltransferase precursor - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - purF gene Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. Indicus|evm.model.PRDE01012051.1.1 Q5YS47 RNH2_NOCFA 68.317 0.877193 0.454183 rnhB - Ribonuclease HII - Nocardia farcinica (strain IFM 10152) - rnhB gene Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Indicus|evm.model.PRDE01012173.1.1 A0R4S7 ACDH2_MYCS2 72.258 0.968553 0.517915 mhpF - Acetaldehyde dehydrogenase 2 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - mhpF gene Indicus|evm.model.PRDE01012295.1.1 Q6TLJ0 DRD4_MUSPF 89.394 0.970149 0.187675 DRD4 - D(4) dopamine receptor - Mustela putorius furo (European domestic ferret) - DRD4 gene Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells. Indicus|evm.model.PRDE01012319.1.1 Q5JU85 IQEC2_HUMAN 96.610 0.991561 0.159274 IQSEC2 - IQ motif and SEC7 domain-containing protein 2 - Homo sapiens (Human) - IQSEC2 gene Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins. Indicus|evm.model.PRDE01012320.1.1 A5PL98 SDHB_DANRE 72.289 0.251534 1.16429 sdhb - Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor - Danio rerio (Zebrafish) - sdhb gene Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Indicus|evm.model.PRDE01012337.1.1 Q92673 SORL_HUMAN 74.737 0.98913 0.0415537 SORL1 - Sortilin-related receptor precursor - Homo sapiens (Human) - SORL1 gene Sorting receptor that directs several proteins to their correct location within the cell (Probable). Along with AP-1 complex, involved Golgi apparatus - endosome sorting (PubMed:17646382). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (PubMed:16174740, PubMed:16407538, PubMed:17855360, PubMed:24523320). May also sort newly produced amyloid-beta peptides to lysosomes for catabolism (PubMed:24523320). Does not affect APP trafficking from the endoplasmic reticulum to Golgi compartments (PubMed:17855360). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor (PubMed:23977241). Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion (PubMed:21994944). Sorting receptor for the GDNF-GFRA1 complex, directing it from the cell surface to endosomes. GDNF is then targeted to lysosomes and degraded, while its receptor GFRA1 recycles back to the cell membrane, resulting in a GDNF clearance pathway. The SORL1-GFRA1 complex further targets RET for endocytosis, but not for degradation, affecting GDNF-induced neurotrophic activities (PubMed:23333276). Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling. In ERBB2-dependent cancer cells, promotes cell proliferation (PubMed:31138794). Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL (PubMed:21385844). Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network (PubMed:18603531). Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue. Does not affect INSR internalization (PubMed:27322061). Plays a role in renal ion homeostasis, controlling the phospho-regulation of SLC12A1/NKCC2 by STK39/SPAK kinase and PPP3CB/calcineurin A beta phosphatase, possibly through intracellular sorting of STK39 and PPP3CB (By similarity). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR. This may promote extracellular matrix proteolysis and hence facilitate cell migration (PubMed:14764453). By acting on the migration of intimal smooth muscle cells, may accelerate intimal thickening following vascular injury (PubMed:14764453). Promotes adhesion of monocytes (PubMed:23486467). Stimulates proliferation and migration of monocytes/macrophages (By similarity). Through its action on intimal smooth muscle cells and macrophages, may accelerate intimal thickening and macrophage foam cell formation in the process of atherosclerosis (By similarity). Regulates hypoxia-enhanced adhesion of hematopoietic stem and progenitor cells to the bone marrow stromal cells via a PLAUR-mediated pathway. This function is mediated by the N-terminal ectodomain (PubMed:23486467). Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet. The N-terminal ectodomain negatively regulates adipose tissue energy expenditure, acting through the inhibition the BMP/Smad pathway (By similarity). May regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation (PubMed:26858303). May regulate IL6 signaling, decreasing cis signaling, possibly by interfering with IL6-binding to membrane-bound IL6R, while up-regulating trans signaling via soluble IL6R (PubMed:28265003). Indicus|evm.model.PRDE01012416.1.1 P62755 RS6_RAT 63.810 0.614925 1.34538 Rps6 - 40S ribosomal protein S6 - Rattus norvegicus (Rat) - Rps6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Indicus|evm.model.PRDE01012468.1.1 Q86SX3 TEDC1_HUMAN 75.127 0.836207 0.468687 TEDC1 - Tubulin epsilon and delta complex protein 1 - Homo sapiens (Human) - TEDC1 gene Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability (By similarity). May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F (PubMed:28796488). Indicus|evm.model.PRDE01012503.1.1 Q96B23 CR025_HUMAN 97.899 0.963415 0.608911 C18orf25 - Uncharacterized protein C18orf25 - Homo sapiens (Human) - C18orf25 gene ubiquitin protein ligase activity, ubiquitin-dependent protein catabolic process Indicus|evm.model.PRDE01012582.1.1 Q8R116 NOTUM_MOUSE 97.917 0.94 0.0994036 Notum - Palmitoleoyl-protein carboxylesterase NOTUM precursor - Mus musculus (Mouse) - Notum gene Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Indicus|evm.model.PRDE01012591.1.1 B0SZ49 NUOD_CAUSK 80.498 0.995851 0.579327 nuoD - NADH-quinone oxidoreductase subunit D - Caulobacter sp. (strain K31) - nuoD gene NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Indicus|evm.model.PRDE01012597.1.1 B1AK53 ESPN_HUMAN 95.402 0.988506 0.101874 ESPN - Espin - Homo sapiens (Human) - ESPN gene Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:29572253). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (By similarity). Involved in the elongation of actin in stereocilia (PubMed:29572253). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation. Indicus|evm.model.PRDE01012609.1.1 Q23716 EF2_CRYPV 74.000 0.992032 0.301683 Elongation factor 2 - Cryptosporidium parvum Indicus|evm.model.PRDE01012627.1.1 Q96HP0 DOCK6_HUMAN 97.581 0.991935 0.0605765 DOCK6 - Dedicator of cytokinesis protein 6 - Homo sapiens (Human) - DOCK6 gene Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). Indicus|evm.model.PRDE01012832.1.1 Q5R5Y0 TPCR1_PONAB 80.000 0.986667 0.0643777 TECPR1 - Tectonin beta-propeller repeat-containing protein 1 - Pongo abelii (Sumatran orangutan) - TECPR1 gene Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity). Indicus|evm.model.PRDE01012869.1.1 Q9Y6Q5 AP1M2_HUMAN 67.500 0.541667 0.170213 AP1M2 - AP-1 complex subunit mu-2 - Homo sapiens (Human) - AP1M2 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Indicus|evm.model.PRDE01012948.1.1 P60321 NANO2_HUMAN 94.828 0.966102 0.427536 NANOS2 - Nanos homolog 2 - Homo sapiens (Human) - NANOS2 gene Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity). Indicus|evm.model.PRDE01013004.1.1 P09084 PAX1_MOUSE 99.153 0.9 0.29148 Pax1 - Paired box protein Pax-1 - Mus musculus (Mouse) - Pax1 gene This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column. Indicus|evm.model.PRDE01013287.1.1 Q6P4Q7 CNNM4_HUMAN 87.349 0.956647 0.446452 CNNM4 - Metal transporter CNNM4 - Homo sapiens (Human) - CNNM4 gene Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. Indicus|evm.model.PRDE01013410.1.1 P03966 MYCN_MOUSE 98.462 0.992308 0.281385 Mycn - N-myc proto-oncogene protein - Mus musculus (Mouse) - Mycn gene Positively regulates the transcription of MYCNOS in neuroblastoma cells. Indicus|evm.model.PRDE01013435.1.1 P9WNB9 END8A_MYCTU 58.730 0.992 0.466418 nei1 - Endonuclease 8 1 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - nei1 gene Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. DNA glycosylase that recognizes and removes damaged pyrimidines. Excises Tg:A (thymine glycol, prefers 5R isomers), Tg:G, 5,6-dihydrouracil:G base pairs and urea:A, also excises oxidized purine derivatives guanidinohydantoin:C and spiroiminodihydantoin:C. Poorly cleaves dsDNA with uracil substitutions, thus also acting as a weak uracil-DNA glycosylase. Acts on DNA bubble and 3'-fork structures, suggesting a role in replication-associated DNA repair. Activity on 7,8-dihydro-8-oxoguanine (8-oxoG) is debated; a report shows weak activity (PubMed:18457574), whereas another shows none (PubMed:20031487). Has AP (apurinic/apyrimidinic) activity and introduces nicks in dsDNA strand, inefficiently cleaves ssDNA with AP sites and uracil. Probably cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Cleaves ssDNA containing an AP site. Complements an E.coli fpg mutY but not nei nth double mutant (PubMed:18457574). Indicus|evm.model.PRDE01013588.1.1 Q0IIH7 ST14_BOVIN 100.000 0.831579 0.111111 ST14 - Suppressor of tumorigenicity 14 protein homolog - Bos taurus (Bovine) - ST14 gene Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity). Indicus|evm.model.PRDE01013594.1.1 Q5H0W6 CCME2_XANOR 72.881 0.805556 0.461538 ccmE2 - Cytochrome c-type biogenesis protein CcmE 2 - Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85) - ccmE2 gene Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Indicus|evm.model.PRDE01013613.1.1 Q5XUX0 FBX31_HUMAN 84.298 0.915385 0.241187 FBXO31 - F-box only protein 31 - Homo sapiens (Human) - FBXO31 gene Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Indicus|evm.model.PRDE01013719.1.1 Q9ET22 DPP2_MOUSE 80.537 0.993289 0.294466 Dpp7 - Dipeptidyl peptidase 2 precursor - Mus musculus (Mouse) - Dpp7 gene Plays an important role in the degradation of some oligopeptides. Indicus|evm.model.PRDE01013739.1.1 Q83CP8 SCPA_COXBU 70.000 0.678161 0.327068 scpA - Segregation and condensation protein A - Coxiella burnetii (strain RSA 493 / Nine Mile phase I) - scpA gene Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. Indicus|evm.model.PRDE01013789.1.2 O86311 MEATP_MYCTU 67.179 0.915094 0.681672 Rv1218c - Multidrug efflux system ATP-binding protein Rv1218c - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1218c gene Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs (PubMed:20921309, PubMed:23143285). Could be involved in the efflux of substrates belonging to the diverse chemical classes of novobiocins, biarylpiperazines, pyridines, bisanilinopyrimidines, pyrroles and, to a smaller extent, pyrazolones (PubMed:20921309). Probably responsible for energy coupling to the transport system (Probable). Indicus|evm.model.PRDE01013847.1.1 Q3T131 COQ3_BOVIN 44.000 0.294643 0.908108 COQ3 - Ubiquinone biosynthesis O-methyltransferase, mitochondrial precursor - Bos taurus (Bovine) - COQ3 gene O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. Indicus|evm.model.PRDE01013958.1.1 O93918 PYC_ASPTE 51.092 0.900794 0.211232 pyc - Pyruvate carboxylase - Aspergillus terreus - pyc gene Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Indicus|evm.model.PRDE01013968.1.1 Q48FR2 MSRB_PSE14 61.475 0.570755 1.61832 msrB - Peptide methionine sulfoxide reductase MsrB - Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) - msrB gene Indicus|evm.model.PRDE01014138.1.1 Q88QT2 MURU_PSEPK 61.165 0.980769 0.466368 murU - N-acetylmuramate alpha-1-phosphate uridylyltransferase - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - murU gene Catalyzes the formation of UDP-N-acetylmuramate (UDP-MurNAc), a crucial precursor of the bacterial peptidoglycan cell wall, from UTP and MurNAc-alpha-1P (PubMed:23831760, PubMed:25767118). Is involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc (PubMed:23831760). Plays a role in intrinsic resistance to fosfomycin, which targets the de novo synthesis of UDP-MurNAc (PubMed:23831760). Is not able to use GlcNAc-alpha-1P and GalNAc-alpha-1P as substrates (PubMed:23831760). Cannot accept other nucleotide triphosphates (ATP, CTP, TTP, or GTP) than UTP (PubMed:25767118). Indicus|evm.model.PRDE01014184.1.1 B0SXF9 COBQ_CAUSK 76.119 0.992537 0.27572 cobQ - Cobyric acid synthase - Caulobacter sp. (strain K31) - cobQ gene Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Indicus|evm.model.PRDE01014221.1.1 Q59661 SDHA_PARDE 49.624 0.992424 0.22 sdhA - Succinate dehydrogenase flavoprotein subunit - Paracoccus denitrificans - sdhA gene Indicus|evm.model.PRDE01014274.1.1 P25490 TYY1_HUMAN 64.179 0.988372 0.207729 YY1 - Transcriptional repressor protein YY1 - Homo sapiens (Human) - YY1 gene Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Indicus|evm.model.PRDE01014313.1.1 A6H584 CO6A5_MOUSE 77.698 0.745946 0.0700758 Col6a5 - Collagen alpha-5(VI) chain precursor - Mus musculus (Mouse) - Col6a5 gene Collagen VI acts as a cell-binding protein. Indicus|evm.model.PRDE01014347.1.1 Q54ST4 RFC5_DICDI 45.387 0.947368 0.821326 rfc5 - Probable replication factor C subunit 5 - Dictyostelium discoideum (Slime mold) - rfc5 gene The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Indicus|evm.model.PRDE01014367.1.1 A0R627 DPRP_MYCS2 62.393 0.935484 0.688889 MSMEG_6402 - Putative decaprenylphosphoryl-5-phosphoribose phosphatase MSMEG_6402 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - MSMEG_6402 gene Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Could be involved in the dephosphorylation of decaprenylphosphoryl-5-phosphoribose (DPPR) to decaprenyl-phospho-ribose (DPR). Indicus|evm.model.PRDE01014378.1.1 A4VFI4 AROE_PSEU5 99.115 0.982456 0.422222 aroE - Shikimate dehydrogenase (NADP(+)) - Pseudomonas stutzeri (strain A1501) - aroE gene Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). Indicus|evm.model.PRDE01014381.1.1 P35436 NMDE1_MOUSE 96.648 0.988889 0.122951 Grin2a - Glutamate receptor ionotropic, NMDA 2A precursor - Mus musculus (Mouse) - Grin2a gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium (PubMed:1374164). Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (By similarity). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:7816096, PubMed:8987814). Indicus|evm.model.PRDE01014436.1.1 Q95KH6 RGF1C_MACFA 100.000 0.8 0.246781 RASGEF1C - Ras-GEF domain-containing family member 1C - Macaca fascicularis (Crab-eating macaque) - RASGEF1C gene Guanine nucleotide exchange factor (GEF). Indicus|evm.model.PRDE01014605.1.1 P02586 TNNC2_RABIT 97.826 0.219512 1.28125 TNNC2 - Troponin C, skeletal muscle - Oryctolagus cuniculus (Rabbit) - TNNC2 gene Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Indicus|evm.model.PRDE01014615.1.1 Q9BQ70 TCF25_HUMAN 70.652 0.938144 0.143491 TCF25 - Transcription factor 25 - Homo sapiens (Human) - TCF25 gene May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development. Indicus|evm.model.PRDE01014635.1.1 Q4UDU8 HSP90_THEAN 99.153 0.991561 0.328255 TA12105 - Heat shock protein 90 - Theileria annulata - TA12105 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Indicus|evm.model.PRDE01014635.1.2 Q4UDU8 HSP90_THEAN 100.000 0.995444 0.608033 TA12105 - Heat shock protein 90 - Theileria annulata - TA12105 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Indicus|evm.model.PRDE01014648.1.1 P78571 RS13_AGABI 71.795 0.777778 0.655629 RPS13 - 40S ribosomal protein S13 - Agaricus bisporus (White button mushroom) - RPS13 gene Indicus|evm.model.PRDE01014730.1.2 Q3K5C0 MDCG_PSEPF 57.711 0.956731 1.00971 mdcG - Phosphoribosyl-dephospho-CoA transferase - Pseudomonas fluorescens (strain Pf0-1) - mdcG gene Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-[acyl-carrier-protein] of the malonate decarboxylase to yield holo-[acyl-carrier-protein]. Indicus|evm.model.PRDE01014730.1.3 P0AAI9 FABD_ECOLI 45.789 0.927461 0.624595 fabD - Malonyl CoA-acyl carrier protein transacylase - Escherichia coli (strain K12) - fabD gene cytosol, [acyl-carrier-protein] S-malonyltransferase activity, fatty acid biosynthetic process Indicus|evm.model.PRDE01014755.1.1 P9WHW3 PPIA_MYCTU 68.421 0.982456 0.93956 ppiA - Peptidyl-prolyl cis-trans isomerase A - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ppiA gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Indicus|evm.model.PRDE01014809.1.1 Q6ZUM4 RHG27_HUMAN 80.000 0.937063 0.160855 ARHGAP27 - Rho GTPase-activating protein 27 - Homo sapiens (Human) - ARHGAP27 gene Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). Indicus|evm.model.PRDE01014835.1.1 Q88JU3 DSD_PSEPK 73.034 0.988764 0.140157 quiC1 - 3-dehydroshikimate dehydratase - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - quiC1 gene Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. Indicus|evm.model.PRDE01014843.1.1 Q56952 YFEA_YERPE 50.000 0.934211 0.244373 yfeA - Periplasmic chelated iron-binding protein YfeA precursor - Yersinia pestis - yfeA gene Part of an ATP-driven transport system YfeABCD for chelated iron. Indicus|evm.model.PRDE01014866.1.1 Q4UFD5 RL18_THEAN 93.617 0.958763 0.527174 RPL18 - 60S ribosomal protein L18 - Theileria annulata - RPL18 gene Indicus|evm.model.PRDE01014977.1.1 Q3V1N1 MFHA1_MOUSE 88.205 0.932692 0.198473 Mfhas1 - Malignant fibrous histiocytoma-amplified sequence 1 homolog - Mus musculus (Mouse) - Mfhas1 gene Probable GTP-binding protein (By similarity). Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways (PubMed:20616063, PubMed:26599367). Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (By similarity). Both inhibits and activates the TLR2-dependent signaling pathway (PubMed:26599367). Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype. It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway. Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway (By similarity). Indicus|evm.model.PRDE01015105.1.1 O95613 PCNT_HUMAN 66.667 0.862069 0.0173861 PCNT - Pericentrin - Homo sapiens (Human) - PCNT gene Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. Indicus|evm.model.PRDE01015123.1.1 P51811 XK_HUMAN 92.771 0.42487 0.434685 XK - Membrane transport protein XK - Homo sapiens (Human) - XK gene May be involved in sodium-dependent transport of neutral amino acids or oligopeptides. Indicus|evm.model.PRDE01015132.1.1 Q02870 ERCC3_DROME 58.427 0.636691 0.348371 hay - General transcription and DNA repair factor IIH helicase subunit XPB - Drosophila melanogaster (Fruit fly) - hay gene ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of haywire/XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of haywire/XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Indicus|evm.model.PRDE01015179.1.1 Q9X909 TOP1_STRCO 57.827 0.996656 0.314076 topA - DNA topoisomerase 1 - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - topA gene Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Indicus|evm.model.PRDE01015239.1.1 Q9Z5J1 NUSA_MYCLE 52.727 0.990909 0.317003 nusA - Transcription termination/antitermination protein NusA - Mycobacterium leprae (strain TN) - nusA gene Participates in both transcription termination and antitermination. Indicus|evm.model.PRDE01015245.1.1 Q7ZVN5 SRP54_DANRE 56.466 0.973094 0.44246 srp54 - Signal recognition particle 54 kDa protein - Danio rerio (Zebrafish) - srp54 gene Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein) (By similarity). Plays a role in proliferation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (PubMed:28972538). Indicus|evm.model.PRDE01015284.1.1 Q9Y4H2 IRS2_HUMAN 91.447 0.920732 0.122571 IRS2 - Insulin receptor substrate 2 - Homo sapiens (Human) - IRS2 gene May mediate the control of various cellular processes by insulin. Indicus|evm.model.PRDE01015313.1.1 P10160 IF5A1_RABIT 56.962 0.98125 1.03896 EIF5A - Eukaryotic translation initiation factor 5A-1 - Oryctolagus cuniculus (Rabbit) - EIF5A gene mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). Indicus|evm.model.PRDE01015320.1.1 O87331 RELA_CORGL 75.172 0.993103 0.190789 relA - GTP pyrophosphokinase - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - relA gene In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. It also has (p)ppGpp-degrading activities. Indicus|evm.model.PRDE01015395.1.1 Q5JTZ9 SYAM_HUMAN 85.417 0.989583 0.0974619 AARS2 - Alanine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - AARS2 gene Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Indicus|evm.model.PRDE01015499.1.1 Q8C428 TMC7_MOUSE 100.000 0.962963 0.0743802 Tmc7 - Transmembrane channel-like protein 7 - Mus musculus (Mouse) - Tmc7 gene Probable ion channel. Indicus|evm.model.PRDE01015501.1.1 A0QS66 RPOC_MYCS2 78.543 0.995951 0.187547 rpoC - DNA-directed RNA polymerase subunit beta' - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - rpoC gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01015504.1.1 Q9NQB0 TF7L2_HUMAN 100.000 0.984127 0.101777 TCF7L2 - Transcription factor 7-like 2 - Homo sapiens (Human) - TCF7L2 gene Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. Indicus|evm.model.PRDE01015534.1.1 O86781 GLMS_STRCO 67.010 0.989691 0.157724 glmS - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - glmS gene Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Indicus|evm.model.PRDE01015623.1.1 Q6BQT6 SEC23_DEBHA 49.535 0.990741 0.579088 SEC23 - Protein transport protein SEC23 - Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) - SEC23 gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). Indicus|evm.model.PRDE01015644.1.1 Q76LV1 HS90B_BOVIN 100.000 0.920398 0.277624 HSP90AB1 - Heat shock protein HSP 90-beta - Bos taurus (Bovine) - HSP90AB1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10. Indicus|evm.model.PRDE01015679.1.1 L7N653 CWLM_MYCTU 50.920 0.95858 0.416256 cwlM - N-acetylmuramoyl-L-alanine amidase CwlM - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - cwlM gene Cell-wall hydrolase that hydrolyzes the amide bond between N-acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to lyse whole mycobacteria, release peptidoglycan from the cell wall of M.luteus and M.smegmatis, and cleave N-acetylmuramoyl-L-alanyl-D-isoglutamine, releasing free N-acetylmuramic acid and dipeptide. Indicus|evm.model.PRDE01015783.1.1 P54296 MYOM2_HUMAN 90.323 0.983871 0.0423208 MYOM2 - Myomesin-2 - Homo sapiens (Human) - MYOM2 gene Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. Indicus|evm.model.PRDE01015794.1.1 A0JN40 KIF3C_BOVIN 100.000 0.987013 0.0972222 KIF3C - Kinesin-like protein KIF3C - Bos taurus (Bovine) - KIF3C gene Microtubule-based anterograde translocator for membranous organelles. Indicus|evm.model.PRDE01015836.1.1 P54198 HIRA_HUMAN 69.492 0.716049 0.079646 HIRA - Protein HIRA - Homo sapiens (Human) - HIRA gene Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Indicus|evm.model.PRDE01015859.1.1 P39693 RECJ_DICD3 63.386 0.996063 0.440972 recJ - Single-stranded-DNA-specific exonuclease RecJ - Dickeya dadantii (strain 3937) - recJ gene Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available (By similarity). Indicus|evm.model.PRDE01015883.1.1 Q1LZH7 KANK2_BOVIN 100.000 0.825858 0.441725 KANK2 - KN motif and ankyrin repeat domain-containing protein 2 - Bos taurus (Bovine) - KANK2 gene Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (By similarity). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). Indicus|evm.model.PRDE01015895.1.2 P0DJ58 RL13_TETTS 51.408 0.679612 1 RPL13 - 60S ribosomal protein L13 - Tetrahymena thermophila (strain SB210) - RPL13 gene Indicus|evm.model.PRDE01015895.1.3 Q95V31 RS16_SPOFR 67.626 0.932432 0.980132 RpS16 - 40S ribosomal protein S16 - Spodoptera frugiperda (Fall armyworm) - RpS16 gene Indicus|evm.model.PRDE01015919.1.1 Q4JVK2 COXX_CORJK 78.125 0.818182 0.246795 ctaB - Protoheme IX farnesyltransferase - Corynebacterium jeikeium (strain K411) - ctaB gene Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. Indicus|evm.model.PRDE01016005.1.2 Q5ZJ54 TCPZ_CHICK 52.399 0.985321 1.0283 CCT6 - T-complex protein 1 subunit zeta - Gallus gallus (Chicken) - CCT6 gene Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). Indicus|evm.model.PRDE01016015.1.1 Q9D7Z7 LYPD5_MOUSE 77.273 0.977528 0.347656 Lypd5 - Ly6/PLAUR domain-containing protein 5 precursor - Mus musculus (Mouse) - Lypd5 gene plasma membrane, laminin binding, cell-matrix adhesion Indicus|evm.model.PRDE01016029.1.1 P46191 SYK_MYCHP 54.930 0.248963 0.493852 lysS - Lysine--tRNA ligase - Mycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21) - lysS gene Indicus|evm.model.PRDE01016050.1.1 Q9I291 GALU_PSEAE 49.587 0.789474 0.544803 galU - UTP--glucose-1-phosphate uridylyltransferase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - galU gene May play a role in stationary phase survival. Indicus|evm.model.PRDE01016080.1.1 Q9TT93 ATS4_BOVIN 96.026 0.974026 0.183552 ADAMTS4 - A disintegrin and metalloproteinase with thrombospondin motifs 4 precursor - Bos taurus (Bovine) - ADAMTS4 gene Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. Indicus|evm.model.PRDE01016136.1.1 P0A3B4 BIPA_SHIFL 54.857 0.96648 0.294893 bipA - 50S ribosomal subunit assembly factor BipA - Shigella flexneri - bipA gene A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA. Indicus|evm.model.PRDE01016141.1.1 B8GW92 HFQ_CAUVN 93.902 0.975904 1.0122 hfq - RNA-binding protein Hfq - Caulobacter vibrioides (strain NA1000 / CB15N) - hfq gene RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Indicus|evm.model.PRDE01016265.1.1 A0QTK2 MTRA_MYCS2 46.535 0.833333 0.526316 mtrA - DNA-binding response regulator MtrA - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - mtrA gene Member of the two-component regulatory system MtrA/MtrB, responding to environmental signals (Probable). Controls expression of a number of genes including dnaA, ripA, fbpB and probably itself. Probably plays a role in cell division. Indicus|evm.model.PRDE01016335.1.1 Q9UNX3 RL26L_HUMAN 68.519 0.93578 0.751724 RPL26L1 - 60S ribosomal protein L26-like 1 - Homo sapiens (Human) - RPL26L1 gene cytosolic large ribosomal subunit, extracellular exosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, ribosomal large subunit biogenesis Indicus|evm.model.PRDE01016336.1.1 P30707 RL9_PEA 62.963 0.955357 0.580311 RPL9 - 60S ribosomal protein L9 - Pisum sativum (Garden pea) - RPL9 gene Indicus|evm.model.PRDE01016400.1.1 A4VPC0 HEM1_PSEU5 95.455 0.984848 0.156398 hemA - Glutamyl-tRNA reductase - Pseudomonas stutzeri (strain A1501) - hemA gene Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). Indicus|evm.model.PRDE01016400.1.2 P42810 Y4667_PSEAE 72.222 0.906977 0.364407 PA4667 - TPR repeat-containing protein PA4667 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA4667 gene Indicus|evm.model.PRDE01016475.1.1 P47895 AL1A3_HUMAN 87.879 0.187135 0.333984 ALDH1A3 - Aldehyde dehydrogenase family 1 member A3 - Homo sapiens (Human) - ALDH1A3 gene NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity). Indicus|evm.model.PRDE01016587.1.1 P9WFD1 Y2026_MYCTU 45.556 0.745763 0.401361 Rv2026c - Universal stress protein Rv2026c - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv2026c gene Indicus|evm.model.PRDE01016814.1.1 O15164 TIF1A_HUMAN 95.868 0.916031 0.124762 TRIM24 - Transcription intermediary factor 1-alpha - Homo sapiens (Human) - TRIM24 gene Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Indicus|evm.model.PRDE01016962.1.1 A4VQV0 URE2_PSEU5 99.010 0.740741 1.33663 ureB - Urease subunit beta - Pseudomonas stutzeri (strain A1501) - ureB gene Indicus|evm.model.PRDE01017046.1.1 P50215 IDH_SPHYA 73.451 0.991189 0.559113 icd - Isocitrate dehydrogenase [NADP] - Sphingobium yanoikuyae - icd gene Indicus|evm.model.PRDE01017100.1.1 P9WQ37 FAC13_MYCTU 48.921 0.925676 0.294235 fadD13 - Long-chain-fatty-acid--CoA ligase FadD13 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - fadD13 gene Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH (PubMed:15937179). Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension (PubMed:19182784, PubMed:20027301, PubMed:22560731). It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16) (PubMed:20027301). Indicus|evm.model.PRDE01017106.1.1 O50562 SAHH_RHOSH 87.640 0.967033 0.196544 ahcY - Adenosylhomocysteinase - Rhodobacter sphaeroides - ahcY gene May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. Indicus|evm.model.PRDE01017106.1.2 Q9ABH0 SAHH_CAUVC 64.539 0.990909 0.237581 ahcY - Adenosylhomocysteinase - Caulobacter vibrioides (strain ATCC 19089 / CB15) - ahcY gene May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. Indicus|evm.model.PRDE01017205.1.1 Q9R1U5 SIK1_RAT 63.768 0.731183 0.119845 Sik1 - Serine/threonine-protein kinase SIK1 - Rattus norvegicus (Rat) - Sik1 gene Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). Indicus|evm.model.PRDE01017224.1.1 Q91918 RA51A_XENLA 64.784 0.733496 1.21726 rad51-a - DNA repair protein RAD51 homolog A - Xenopus laevis (African clawed frog) - rad51-a gene Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Indicus|evm.model.PRDE01017292.1.1 Q5YSC6 IF2_NOCFA 78.750 0.975309 0.0835913 infB - Translation initiation factor IF-2 - Nocardia farcinica (strain IFM 10152) - infB gene One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. Indicus|evm.model.PRDE01017292.1.2 Q5YSC8 RBFA_NOCFA 65.493 0.903846 1.06122 rbfA - Ribosome-binding factor A - Nocardia farcinica (strain IFM 10152) - rbfA gene One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. Indicus|evm.model.PRDE01017317.1.1 Q96RV3 PCX1_HUMAN 96.296 0.490741 0.0461341 PCNX1 - Pecanex-like protein 1 - Homo sapiens (Human) - PCNX1 gene Indicus|evm.model.PRDE01017335.1.1 Q8JZM8 MUC4_MOUSE 72.152 0.866667 0.02614 Muc4 - Mucin-4 precursor - Mus musculus (Mouse) - Muc4 gene May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation (By similarity). Indicus|evm.model.PRDE01017376.1.1 P24197 YGID_ECOLI 55.435 0.90099 0.372694 ygiD - 4,5-DOPA dioxygenase extradiol - Escherichia coli (strain K12) - ygiD gene In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown. Indicus|evm.model.PRDE01017390.1.1 P50570 DYN2_HUMAN 56.250 0.95 0.114943 DNM2 - Dynamin-2 - Homo sapiens (Human) - DNM2 gene Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis (PubMed:33713620). Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Indicus|evm.model.PRDE01017471.1.1 Q14693 LPIN1_HUMAN 71.698 0.882353 0.133708 LPIN1 - Phosphatidate phosphatase LPIN1 - Homo sapiens (Human) - LPIN1 gene Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:20231281). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). Indicus|evm.model.PRDE01017533.1.1 P31961 EDD_PSEAE 76.037 0.407547 0.871711 edd - Phosphogluconate dehydratase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - edd gene Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate. Indicus|evm.model.PRDE01017658.1.1 P18275 ARCD_PSEAE 49.643 0.98913 0.572614 arcD - Arginine/ornithine antiporter - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - arcD gene Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway. Indicus|evm.model.PRDE01017894.1.1 P61207 ARF3_TAKRU 100.000 0.962963 0.298343 arf3 - ADP-ribosylation factor 3 - Takifugu rubripes (Japanese pufferfish) - arf3 gene GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Indicus|evm.model.PRDE01017910.1.1 O28972 Y1297_ARCFU 45.299 0.564356 0.55116 AF_1297 - Cell division cycle protein 48 homolog AF_1297 - Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) - AF_1297 gene Indicus|evm.model.PRDE01018077.1.1 Q6AGQ7 SYW_LEIXX 67.500 0.718182 0.326409 trpS - Tryptophan--tRNA ligase - Leifsonia xyli subsp. xyli (strain CTCB07) - trpS gene Catalyzes the attachment of tryptophan to tRNA(Trp). Indicus|evm.model.PRDE01018078.1.1 Q96F45 ZN503_HUMAN 99.556 0.99115 0.349845 ZNF503 - Zinc finger protein 503 - Homo sapiens (Human) - ZNF503 gene May function as a transcriptional repressor. Indicus|evm.model.PRDE01018140.1.1 H1ZV37 GEOB_CASDE 56.977 0.885417 0.200837 geoB - Geranial dehydrogenase - Castellaniella defragrans - geoB gene Catalyzes the NAD(+)-dependent oxidation of geranial to geranic acid. Is involved in the anaerobic degradation of the monoterpene beta-myrcene. Seems to be specific for the trans-isomer geranial, since it does not act on the cis-isomer neral. Indicus|evm.model.PRDE01018451.1.1 Q6QNM1 KC1_TOXGO 82.828 0.87574 1.04321 Casein kinase I - Toxoplasma gondii Indicus|evm.model.PRDE01018477.1.1 A4QAN2 Y315_CORGB 66.265 0.719298 1.1068 cgR_0315 - Nucleoid-associated protein cgR_0315 - Corynebacterium glutamicum (strain R) - cgR_0315 gene Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. Indicus|evm.model.PRDE01018637.1.1 Q9Y2P5 S27A5_HUMAN 79.259 0.950355 0.204348 SLC27A5 - Bile acyl-CoA synthetase - Homo sapiens (Human) - SLC27A5 gene Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:10749848, PubMed:11980911). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed:10749848, PubMed:11980911). Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed:10479480). In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Exhibits long-chain fatty acids (LCFA) transport activity (PubMed:20530735). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity). Indicus|evm.model.PRDE01018727.1.1 A8PVM6 CTU1_MALGO 50.811 0.844037 0.58445 NCS6 - Cytoplasmic tRNA 2-thiolation protein 1 - Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus) - NCS6 gene Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. Indicus|evm.model.PRDE01018797.1.1 Q3SZG6 FA92A_BOVIN 100.000 0.886364 0.305556 FAM92A - Protein FAM92A - Bos taurus (Bovine) - FAM92A gene Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis. In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis. Indicus|evm.model.PRDE01018844.1.1 Q13488 VPP3_HUMAN 81.319 0.978261 0.110843 TCIRG1 - V-type proton ATPase 116 kDa subunit a3 - Homo sapiens (Human) - TCIRG1 gene Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. Indicus|evm.model.PRDE01018968.1.1 C5C9U0 PNP_MICLC 93.897 0.995305 0.282869 pnp - Polyribonucleotide nucleotidyltransferase - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - pnp gene Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Indicus|evm.model.PRDE01019444.1.1 O55176 PJA1_MOUSE 83.406 0.995633 0.396194 Pja1 - E3 ubiquitin-protein ligase Praja-1 - Mus musculus (Mouse) - Pja1 gene Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting. Indicus|evm.model.PRDE01019467.1.1 Q6PAJ1 BCR_MOUSE 90.741 0.569892 0.0732283 Bcr - Breakpoint cluster region protein - Mus musculus (Mouse) - Bcr gene Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (PubMed:20962234). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (By similarity). Indicus|evm.model.PRDE01019580.1.1 P17983 YIA1_RHISP 92.857 0.25625 1.72043 Insertion element ISR1 uncharacterized 11 kDa protein A1 - Rhizobium sp. Indicus|evm.model.PRDE01019580.1.2 P17985 YIA3_RHISP 97.727 0.977528 1.01136 Insertion element ISR1 uncharacterized 10 kDa protein A3 - Rhizobium sp. Indicus|evm.model.PRDE01019679.1.1 Q49649 Y493_MYCLE 55.932 0.982759 0.266055 ML0493 - Uncharacterized protein ML0493 - Mycobacterium leprae (strain TN) - ML0493 gene Indicus|evm.model.PRDE01019890.1.1 B0T6E7 SYL_CAUSK 73.373 0.982456 0.198606 leuS - Leucine--tRNA ligase - Caulobacter sp. (strain K31) - leuS gene Indicus|evm.model.PRDE01019901.1.1 Q5Z3Z8 DNAA_NOCFA 73.214 0.985866 0.427492 dnaA - Chromosomal replication initiator protein DnaA - Nocardia farcinica (strain IFM 10152) - dnaA gene Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Indicus|evm.model.PRDE01019937.1.1 A8I1Q0 CALM_HETTR 85.906 0.986577 1 Calmodulin - Heterocapsa triquetra (Dinoflagellate) Indicus|evm.model.PRDE01020011.1.1 C5CAA3 MQO_MICLC 67.480 0.991914 0.751012 mqo - Probable malate:quinone oxidoreductase - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - mqo gene Indicus|evm.model.PRDE01020360.1.1 Q3ZCH5 ZA2G_BOVIN 100.000 0.979592 0.327759 AZGP1 - Zinc-alpha-2-glycoprotein precursor - Bos taurus (Bovine) - AZGP1 gene Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. Indicus|evm.model.PRDE01020405.1.1 Q82EL5 ACSA_STRAW 68.224 0.972477 0.167178 acsA - Acetyl-coenzyme A synthetase - Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) - acsA gene Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Indicus|evm.model.PRDE01020467.1.1 Q3T113 TMIG1_BOVIN 100.000 0.956044 0.348659 TMIGD1 - Transmembrane and immunoglobulin domain-containing protein 1 precursor - Bos taurus (Bovine) - TMIGD1 gene May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival. Indicus|evm.model.PRDE01020504.1.1 P49717 MCM4_MOUSE 100.000 0.480916 0.151972 Mcm4 - DNA replication licensing factor MCM4 - Mus musculus (Mouse) - Mcm4 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Indicus|evm.model.PRDE01020509.1.1 Q8FR29 PUR9_COREF 66.372 0.995392 0.416507 purH - Bifunctional purine biosynthesis protein PurH - Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) - purH gene Indicus|evm.model.PRDE01020571.1.1 C5BUY7 NRDI_BEUC1 63.158 0.974138 0.84058 nrdI - Protein NrdI - Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432) - nrdI gene Probably involved in ribonucleotide reductase function. Indicus|evm.model.PRDE01020571.1.2 P0CH00 RIR1B_MYCS2 80.275 0.955947 0.314404 nrdE2 - Ribonucleoside-diphosphate reductase subunit alpha 2 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - nrdE2 gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Indicus|evm.model.PRDE01020593.1.3 Q82P90 IABF_STRAW 54.921 0.960245 0.679834 Araf43A - Extracellular exo-alpha-(1->5)-L-arabinofuranosidase precursor - Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) - Araf43A gene Involved in the degradation of arabinan and is a key enzyme in the complete degradation of the plant cell wall. Catalyzes only the cleavage of terminal alpha-(1->5) arabinofuranosyl bonds of arabinan present in the arabinofuranosyl polysaccharides or oligosaccharides. It cannot act on other arabinose-containing polysaccharides and arabinoxylo-oligosaccharides. Indicus|evm.model.PRDE01020593.1.4 P96517 MELY_ENTCC 45.763 0.931217 0.444706 melY - Melibiose permease - Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56) - melY gene Responsible for transport of melibiose into the cell, with the concomitant import of a proton (symport system) (PubMed:9209070, PubMed:9375783, PubMed:12775706, PubMed:18177889). Can also transport lactose, and has weak activity with maltose (PubMed:18177889, PubMed:12775706). Cannot transport the analog methyl-1-thio-beta,D-galactopyranoside (TMG) (PubMed:18177889). Indicus|evm.model.PRDE01020593.1.5 Q2YUL7 PDP_STAAB 62.704 0.993039 0.995381 pdp - Pyrimidine-nucleoside phosphorylase - Staphylococcus aureus (strain bovine RF122 / ET3-1) - pdp gene Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Indicus|evm.model.PRDE01020593.1.6 P39140 DEOR_BACSU 48.993 0.993311 0.955272 deoR - Deoxyribonucleoside regulator - Bacillus subtilis (strain 168) - deoR gene Negative regulator of the dra-nupC-pdp operon. DeoR binds cooperatively to the operator DNA, which consists of a palindrome and a direct repeat sequence located 3' to the palindrome. Indicus|evm.model.PRDE01020593.1.8 Q03Q52 DEOD_LACBA 76.724 0.982979 1 deoD - Purine nucleoside phosphorylase DeoD-type - Lactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947) - deoD gene Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Indicus|evm.model.PRDE01020593.1.9 Q38XI1 DEOB_LACSS 78.788 0.994962 1.00253 deoB - Phosphopentomutase - Lactobacillus sakei subsp. sakei (strain 23K) - deoB gene Phosphotransfer between the C1 and C5 carbon atoms of pentose. Indicus|evm.model.PRDE01020593.1.10 Q38XI2 DEOC_LACSS 76.279 0.990741 1 deoC - Deoxyribose-phosphate aldolase - Lactobacillus sakei subsp. sakei (strain 23K) - deoC gene Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Indicus|evm.model.PRDE01020593.1.11 Q8CT84 PPI1_STAES 59.391 0.989796 0.994924 SE_0648 - Putative peptidyl-prolyl cis-trans isomerase - Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) - SE_0648 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Indicus|evm.model.PRDE01020593.1.14 O32210 GR_BACSU 47.744 0.94306 1.01812 yvgN - Glyoxal reductase - Bacillus subtilis (strain 168) - yvgN gene Reduces glyoxal and methylglyoxal (2-oxopropanal). Is not involved in the vitamin B6 biosynthesis. Indicus|evm.model.PRDE01020593.1.15 Q725C4 AGUA2_LISMF 56.981 0.5 1.42547 aguA2 - Putative agmatine deiminase 2 - Listeria monocytogenes serotype 4b (strain F2365) - aguA2 gene Indicus|evm.model.PRDE01020593.1.16 Q8RPX2 AGUA_LACSS 77.976 0.988201 0.928767 aguA - Putative agmatine deiminase - Lactobacillus sakei subsp. sakei (strain 23K) - aguA gene Indicus|evm.model.PRDE01020593.1.17 Q03HM9 PTC_PEDPA 90.357 0.992883 0.81686 ptcA - Putrescine carbamoyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - ptcA gene Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine. Indicus|evm.model.PRDE01020593.1.21 P21939 XYLB_LACPE 62.128 0.907157 1.03194 xylB - Xylulose kinase - Lactiplantibacillus pentosus - xylB gene Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate. Indicus|evm.model.PRDE01020593.1.22 P42911 PTPD_ECOLI 54.077 0.982906 0.889734 agaD - N-acetylgalactosamine permease IID component - Escherichia coli (strain K12) - agaD gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. Indicus|evm.model.PRDE01020593.1.23 P42909 PTPB1_ECOLI 61.404 0.439689 1.62658 agaB - N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1 - Escherichia coli (strain K12) - agaB gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. Indicus|evm.model.PRDE01020593.1.24 P0AFV2 YHID_ECOLI 48.428 0.699115 1.05116 yhiD - Putative magnesium transporter YhiD - Escherichia coli (strain K12) - yhiD gene Could be involved in magnesium uptake. Indicus|evm.model.PRDE01020593.1.25 Q6GKB4 PTXBC_STAAR 64.407 0.508658 1.90909 SAR0193 - PTS system MurNAc-GlcNAc-specific EIIBC component - Staphylococcus aureus (strain MRSA252) - SAR0193 gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in the uptake and phosphorylation of MurNAc-GlcNAc, the principle peptidoglycan turnover product of S.aureus, yielding cytoplasmic MurNAc 6P-GlcNAc. Indicus|evm.model.PRDE01020593.1.26 Q88SB0 MURQ2_LACPL 74.377 0.992908 0.952703 murQ2 - N-acetylmuramic acid 6-phosphate etherase 2 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - murQ2 gene Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Indicus|evm.model.PRDE01020593.1.28 P40398 YHXD_BACSU 57.895 0.981273 0.892977 yhxD - Uncharacterized oxidoreductase YhxD - Bacillus subtilis (strain 168) - yhxD gene oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Indicus|evm.model.PRDE01020593.1.30 Q03HS1 F16PC_PEDPA 80.000 0.99529 0.998433 fbp - Fructose-1,6-bisphosphatase class 3 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - fbp gene Indicus|evm.model.PRDE01020593.1.34 Q833W8 LACD2_ENTFA 66.545 0.691919 1.19637 lacD2 - Tagatose 1,6-diphosphate aldolase 2 - Enterococcus faecalis (strain ATCC 700802 / V583) - lacD2 gene Indicus|evm.model.PRDE01020593.1.35 P65647 LACB_STAAN 65.306 0.802198 1.06433 lacB - Galactose-6-phosphate isomerase subunit LacB - Staphylococcus aureus (strain N315) - lacB gene Indicus|evm.model.PRDE01020593.1.46 O34423 YJQC_BACSU 63.596 0.957806 0.852518 yjqC - Uncharacterized protein YjqC - Bacillus subtilis (strain 168) - yjqC gene Indicus|evm.model.PRDE01020593.1.47 Q88SE8 GAL1_LACPL 56.571 0.654428 1.19638 galK - Galactokinase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - galK gene Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Indicus|evm.model.PRDE01020593.1.48 Q8X529 GPR_ECO57 54.242 0.990854 0.947977 gpr - L-glyceraldehyde 3-phosphate reductase - Escherichia coli O157:H7 - gpr gene Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non-enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo (By similarity). Indicus|evm.model.PRDE01020600.1.1 O86781 GLMS_STRCO 69.474 0.989474 0.154472 glmS - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - glmS gene Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Indicus|evm.model.PRDE01021871.1.1 Q9KYR9 ISPG2_STRCO 86.893 0.995146 0.535065 ispG2 - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) 2 - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - ispG2 gene Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Indicus|evm.model.PRDE01021898.1.1 Q63258 ITA7_RAT 95.833 0.972603 0.0643172 Itga7 - Integrin alpha-7 precursor - Rattus norvegicus (Rat) - Itga7 gene Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells (By similarity). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation. Indicus|evm.model.PRDE01021994.1.1 P30341 MERA_STRLI 57.196 0.988971 0.57384 merA - Mercuric reductase - Streptomyces lividans - merA gene Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). Indicus|evm.model.PRDE01022111.1.1 Q9PEH0 PYRH_XYLFA 82.609 0.378151 0.481781 pyrH - Uridylate kinase - Xylella fastidiosa (strain 9a5c) - pyrH gene Catalyzes the reversible phosphorylation of UMP to UDP. Indicus|evm.model.PRDE01022113.1.1 Q6Q760 NALCN_RAT 100.000 0.98 0.0287687 Nalcn - Sodium leak channel non-selective protein - Rattus norvegicus (Rat) - Nalcn gene Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability. Indicus|evm.model.PRDE01022187.1.1 B9E9G9 LUTB_MACCJ 52.804 0.817121 0.538784 lutB - Lactate utilization protein B - Macrococcus caseolyticus (strain JCSC5402) - lutB gene Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate. Indicus|evm.model.PRDE01022343.1.2 P9WHH7 LPDA_MYCTU 65.000 0.980198 0.204868 lpdA - NAD(P)H dehydrogenase (quinone) - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - lpdA gene May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4-benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH. Indicus|evm.model.PRDE01022379.1.1 Q28727 NTCP2_RABIT 86.885 0.952756 0.365994 SLC10A2 - Ileal sodium/bile acid cotransporter - Oryctolagus cuniculus (Rabbit) - SLC10A2 gene Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity). Indicus|evm.model.PRDE01022388.1.1 C5CC73 RL10_MICLC 100.000 0.992308 0.751445 rplJ - 50S ribosomal protein L10 - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - rplJ gene Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Indicus|evm.model.PRDE01022444.1.1 B8GW31 PARA_CAUVN 52.174 0.858491 0.397004 parA - Chromosome partitioning protein ParA - Caulobacter vibrioides (strain NA1000 / CB15N) - parA gene Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Indicus|evm.model.PRDE01022509.1.1 Q9X8H1 Y3348_STRCO 69.643 0.597826 0.297735 SCO3348 - Uncharacterized protein SCO3348 - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - SCO3348 gene pyrophosphatase activity, phosphorus metabolic process Indicus|evm.model.PRDE01022519.1.1 C5C9T9 RS15_MICLC 96.610 0.983051 0.662921 rpsO - 30S ribosomal protein S15 - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - rpsO gene One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. Indicus|evm.model.PRDE01022603.1.1 P48050 KCNJ4_HUMAN 99.065 0.981481 0.242697 KCNJ4 - Inward rectifier potassium channel 4 - Homo sapiens (Human) - KCNJ4 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). Indicus|evm.model.PRDE01022638.1.1 Q80VP0 TCPR1_MOUSE 89.286 0.976471 0.0728988 Tecpr1 - Tectonin beta-propeller repeat-containing protein 1 - Mus musculus (Mouse) - Tecpr1 gene Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity). Indicus|evm.model.PRDE01022695.1.1 Q6PW77 GOOX_SARSR 54.902 0.438596 0.228457 gluO - Glucooligosaccharide oxidase precursor - Sarocladium strictum (Black bundle disease fungus) - gluO gene Catalyzes the selective oxidation of C1 hydroxyl moieties on mono- and disaccharides with concomitant reduction of molecular oxygen to hydrogen peroxide. This results in the formation of the corresponding lactones, which typically undergo spontaneous hydrolysis. Glucooligosaccharide oxidase is able to oxidize the monosaccharide D-glucose as well as the disaccharides maltose, cellobiose, and lactose. In addition, it shows high selectivity for cello- and maltooligosaccharides, indicating that glucooligosaccharide oxidase prefers oligosaccharides with a beta-D-glucosyl unit on the reducing end and additional sugar units linked by alpha- or beta-1,4 glucosidic bonds. Indicus|evm.model.PRDE01022712.1.1 Q827Q8 CARA_STRAW 67.143 0.971831 0.186842 carA - Carbamoyl-phosphate synthase small chain - Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) - carA gene Indicus|evm.model.PRDE01022829.1.1 Q99719 SEPT5_HUMAN 98.876 0.633094 0.376694 SEPTIN5 - Septin-5 - Homo sapiens (Human) - SEPTIN5 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). Indicus|evm.model.PRDE01022855.1.1 Q8NQ22 SYA_CORGL 73.034 0.988764 0.100225 alaS - Alanine--tRNA ligase - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - alaS gene Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. Indicus|evm.model.PRDE01022935.1.2 O17438 DHX15_STRPU 57.179 0.758 1.0989 PRP1 - Putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 - Strongylocentrotus purpuratus (Purple sea urchin) - PRP1 gene Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. Indicus|evm.model.PRDE01023156.1.1 P9WMH3 CRPL_MYCTU 85.088 0.991228 0.508929 crp - CRP-like cAMP-activated global transcriptional regulator - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - crp gene Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. The CRP regulon is predicted to contain about 115 genes. Some genes are activated by CRP (rpfA, whiB1) while others are repressed (fadD10). There are 2 CRP-binding sites in the promoter of whiB1, at low concentrations of CRP with or without cAMP transcription of whiB1 is enhanced via site CRP1, then repressed as site CRP2 is filled. Indicus|evm.model.PRDE01023189.1.1 P9WGD7 SRP54_MYCTU 71.552 0.991379 0.220952 ffh - Signal recognition particle protein - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ffh gene Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity). Most of the substrate proteins are involved in stress regulation, lipid metabolism, intermediary metabolism, and cell wall processes (PubMed:29361248). Shows GTPase activity (PubMed:22534010). Indicus|evm.model.PRDE01023244.1.1 C5CA38 RSMH_MICLC 97.396 0.989637 0.583082 rsmH - Ribosomal RNA small subunit methyltransferase H - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - rsmH gene Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. Indicus|evm.model.PRDE01023423.1.1 Q55587 Y335_SYNY3 64.948 0.904762 0.218295 sll0335 - Uncharacterized protein sll0335 - Synechocystis sp. (strain PCC 6803 / Kazusa) - sll0335 gene Indicus|evm.model.PRDE01023556.1.1 Q9K0V1 Y459_NEIMB 45.968 0.911111 0.365854 NMB0459 - Uncharacterized protein NMB0459 - Neisseria meningitidis serogroup B (strain MC58) - NMB0459 gene Indicus|evm.model.PRDE01023612.1.1 O53582 AFTB_MYCTU 50.000 0.779412 0.108453 aftB - Terminal beta-(1->2)-arabinofuranosyltransferase precursor - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - aftB gene Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues from the sugar donor decaprenyl-phospho-arabinose (DPA) to the arabinan domain to form terminal beta-(1->2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids. Indicus|evm.model.PRDE01023766.1.1 Q8CFK2 TF3B_MOUSE 100.000 0.871429 0.10355 Brf1 - Transcription factor IIIB 90 kDa subunit - Mus musculus (Mouse) - Brf1 gene General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. Indicus|evm.model.PRDE01023880.1.1 Q9A458 PARD4_CAUVC 46.774 0.7125 0.833333 parD4 - Antitoxin ParD4 - Caulobacter vibrioides (strain ATCC 19089 / CB15) - parD4 gene Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of cognate toxin ParE4, but no other RelE or ParE toxin. Indicus|evm.model.PRDE01024192.1.1 Q59200 ASPA_CORGL 70.130 0.995671 0.439163 aspA - Aspartate ammonia-lyase - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - aspA gene Indicus|evm.model.PRDE01024273.1.1 P9WGD7 SRP54_MYCTU 59.732 0.865497 0.325714 ffh - Signal recognition particle protein - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ffh gene Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity). Most of the substrate proteins are involved in stress regulation, lipid metabolism, intermediary metabolism, and cell wall processes (PubMed:29361248). Shows GTPase activity (PubMed:22534010). Indicus|evm.model.PRDE01024318.1.1 Q86YS6 RAB43_HUMAN 96.875 0.954545 0.311321 RAB43 - Ras-related protein Rab-43 - Homo sapiens (Human) - RAB43 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Indicus|evm.model.PRDE01024464.1.1 Q5SKN9 LCFCS_THET8 43.750 0.887324 0.131238 TTHA0604 - Long-chain-fatty-acid--CoA ligase - Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) - TTHA0604 gene Catalyzes the esterification of a number of long chain fatty acids with CoA, resulting in the formation of long-chain fatty acyl-CoA. Myristate (C14) is the most efficiently processed fatty acid, followed by palmitate (C16). Also catalyzes the esterification of stearate (C18) and laurate (C12), but at lower efficiency. Does not catalyze the esterification of the unsaturated fatty acids mysteroleic and palmitoleic acids in vitro. Indicus|evm.model.PRDE01024489.1.1 B2GKG9 MIAA_KOCRD 65.596 0.96875 0.715655 miaA - tRNA dimethylallyltransferase - Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201) - miaA gene Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). Indicus|evm.model.PRDE01024630.1.1 Q3TR08 FNDC4_MOUSE 100.000 0.985075 0.290043 Fndc4 - Fibronectin type III domain-containing protein 4 precursor - Mus musculus (Mouse) - Fndc4 gene Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. Indicus|evm.model.PRDE01024678.1.1 Q86Y37 CACL1_HUMAN 80.000 0.845238 0.227642 CACUL1 - CDK2-associated and cullin domain-containing protein 1 - Homo sapiens (Human) - CACUL1 gene Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. Indicus|evm.model.PRDE01024706.1.1 P25737 LYSP_ECOLI 61.850 0.988439 0.353783 lysP - Lysine-specific permease - Escherichia coli (strain K12) - lysP gene Permease that is involved in the transport across the cytoplasmic membrane of lysine. Indicus|evm.model.PRDE01025095.1.1 P9WMB4 ACYLT_MYCTO 63.265 0.960591 0.642405 MT2686 - Phosphatidylinositol mannoside acyltransferase - Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) - MT2686 gene Catalyzes the acylation to the position 6 of the alpha-1,2-linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). Indicus|evm.model.PRDE01025110.1.1 Q6A9R8 GCSP_CUTAK 69.143 0.994286 0.176056 gcvP - Glycine dehydrogenase (decarboxylating) - Cutibacterium acnes (strain DSM 16379 / KPA171202) - gcvP gene The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Indicus|evm.model.PRDE01025138.1.1 C5CB51 MNMA_MICLC 73.913 0.970149 0.177249 mnmA - tRNA-specific 2-thiouridylase MnmA - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - mnmA gene Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. Indicus|evm.model.PRDE01025246.1.1 P9WPM9 C135B_MYCTU 45.312 0.962121 0.279661 cyp135B1 - Putative cytochrome P450 135B1 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - cyp135B1 gene cytosol Indicus|evm.model.PRDE01025248.1.1 Q8NFQ5 BPIB6_HUMAN 84.211 0.925926 0.178808 BPIFB6 - BPI fold-containing family B member 6 precursor - Homo sapiens (Human) - BPIFB6 gene Indicus|evm.model.PRDE01025280.1.1 P9WMS9 AGBR_MYCTU 54.902 0.951923 0.859504 Rv3789 - Arabinogalactan biosynthesis recruiting protein Rv3789 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv3789 gene Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis. Indicus|evm.model.PRDE01025345.1.1 P9WFS1 TYPH_MYCTU 69.375 0.97546 0.381733 deoA - Thymidine phosphorylase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - deoA gene The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Indicus|evm.model.PRDE01025370.1.1 A0QNG3 PBPA_MYCS2 48.223 0.946602 0.419552 pbpA - Peptidoglycan D,D-transpeptidase PbpA - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - pbpA gene Transpeptidase that catalyzes cross-linking of the peptidoglycan cell wall. Required for the regulation of cell length. Indicus|evm.model.PRDE01025478.1.1 Q7TTR2 FAA32_MYCBO 55.521 0.957055 0.511774 fadD32 - Long-chain-fatty-acid--AMP ligase FadD32 - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - fadD32 gene Involved in the biosynthesis of mycolic acids (By similarity). Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the phosphopantetheine arm of the polyketide synthase Pks13 for further chain extension (By similarity). Indicus|evm.model.PRDE01025518.1.1 Q82I33 HUTH_STRAW 72.671 0.993789 0.314453 hutH - Histidine ammonia-lyase - Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) - hutH gene Indicus|evm.model.PRDE01025520.1.1 A4IFE3 ACTY_BOVIN 93.976 0.738739 0.295213 ACTR1B - Beta-centractin - Bos taurus (Bovine) - ACTR1B gene Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity). Indicus|evm.model.PRDE01025526.1.1 C5C713 PAND_MICLC 92.233 0.990291 0.710345 panD - Aspartate 1-decarboxylase precursor - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - panD gene Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. Indicus|evm.model.PRDE01025527.1.1 Q743Y4 PAND_MYCPA 88.750 0.9875 0.559441 panD - Aspartate 1-decarboxylase precursor - Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) - panD gene Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. Indicus|evm.model.PRDE01025527.1.2 Q0S8D5 PANC_RHOJR 69.565 0.909747 0.887821 panC - Pantothenate synthetase - Rhodococcus jostii (strain RHA1) - panC gene Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Indicus|evm.model.PRDE01025626.1.1 Q5ZJH9 DKC1_CHICK 66.667 0.689655 0.224806 DKC1 - H/ACA ribonucleoprotein complex subunit DKC1 - Gallus gallus (Chicken) - DKC1 gene Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Indicus|evm.model.PRDE01025633.1.1 A1B962 RLME_PARDP 88.000 0.943038 0.617188 rlmE - Ribosomal RNA large subunit methyltransferase E - Paracoccus denitrificans (strain Pd 1222) - rlmE gene Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. Indicus|evm.model.PRDE01025655.1.1 Q0NXR6 ACAD8_BOVIN 51.389 0.972789 0.353365 ACAD8 - Isobutyryl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACAD8 gene Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA. Indicus|evm.model.PRDE01025715.1.1 A0QF52 MURG_MYCA1 60.403 0.91875 0.392157 murG - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase - Mycobacterium avium (strain 104) - murG gene Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). Indicus|evm.model.PRDE01025892.1.1 Q4P4G8 NKAP_USTMA 65.152 0.340314 0.331023 UMAG_04995 - NKAP family protein UM04995 - Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) - UMAG_04995 gene nucleus, regulation of gene expression Indicus|evm.model.PRDE01025906.1.1 P17424 RIR4_SALTY 73.846 0.8 0.250784 nrdF - Ribonucleoside-diphosphate reductase 2 subunit beta - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - nrdF gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2F contains the tyrosyl radical required for catalysis. Indicus|evm.model.PRDE01025906.1.2 P0CH00 RIR1B_MYCS2 80.317 0.993671 0.437673 nrdE2 - Ribonucleoside-diphosphate reductase subunit alpha 2 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - nrdE2 gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Indicus|evm.model.PRDE01025947.1.1 E1V8I1 GLTB_HALED 75.182 0.985507 0.0931174 gltB - Glutamate synthase [NADPH] large chain - Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9) - gltB gene Catalyzes the conversion of L-glutamine and 2-oxoglutarate into two molecules of L-glutamate. Indicus|evm.model.PRDE01025951.1.1 P31640 Y2524_CUPNH 56.204 0.992701 0.200586 H16_A2524 - Uncharacterized symporter H16_A2524 - Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) - H16_A2524 gene Indicus|evm.model.PRDE01026112.1.1 Q64303 PAK2_RAT 100.000 0.982759 0.110687 Pak2 - Serine/threonine-protein kinase PAK 2 - Rattus norvegicus (Rat) - Pak2 gene Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity). Indicus|evm.model.PRDE01026279.1.1 Q9RJZ6 ALDH_STRCO 80.000 0.989474 0.187377 SCO1174 - Probable aldehyde dehydrogenase - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - SCO1174 gene Indicus|evm.model.PRDE01026290.1.2 C5C6P4 DCDB_MICLC 100.000 0.983871 0.321244 dcd - dCTP deaminase, dUMP-forming - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - dcd gene Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. Indicus|evm.model.PRDE01026467.1.1 Q88NX8 GLPK_PSEPK 78.182 0.771429 0.140281 glpK - Glycerol kinase - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - glpK gene Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate. Indicus|evm.model.PRDE01026792.1.1 J9VWU3 ATM1_CRYNH 52.066 0.97561 0.168033 ATM1 - Iron-sulfur clusters transporter ATM1, mitochondrial precursor - Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) - ATM1 gene Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of mitochondrial Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (PubMed:29089435, PubMed:29420779). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity). Plays a role during copper stress, in a manner dependent on the copper metalloregulatory transcription factor CUF1 (PubMed:29089435). Indicus|evm.model.PRDE01026866.1.1 D4ABB8 ATP9B_RAT 50.000 0.601594 0.218832 Atp9b - Probable phospholipid-transporting ATPase IIB - Rattus norvegicus (Rat) - Atp9b gene endosome, perinuclear region of cytoplasm, plasma membrane, trans-Golgi network, ATPase-coupled intramembrane lipid transporter activity, endocytosis, phospholipid translocation, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Indicus|evm.model.PRDE01026923.1.1 Q8IW03 SIAH3_HUMAN 88.028 0.986014 0.531599 SIAH3 - Seven in absentia homolog 3 - Homo sapiens (Human) - SIAH3 gene Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria. Indicus|evm.model.PRDE01026924.1.1 Q8IW03 SIAH3_HUMAN 88.028 0.986014 0.531599 SIAH3 - Seven in absentia homolog 3 - Homo sapiens (Human) - SIAH3 gene Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria. Indicus|evm.model.PRDE01026926.1.1 Q9H6S3 ES8L2_HUMAN 83.333 0.976471 0.118881 EPS8L2 - Epidermal growth factor receptor kinase substrate 8-like protein 2 - Homo sapiens (Human) - EPS8L2 gene Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). Indicus|evm.model.PRDE01026931.1.1 Q12996 CSTF3_HUMAN 99.000 0.942857 0.146444 CSTF3 - Cleavage stimulation factor subunit 3 - Homo sapiens (Human) - CSTF3 gene One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. Indicus|evm.model.PRDE01026962.1.1 P75823 LTAE_ECOLI 63.636 0.984962 0.399399 ltaE - Low specificity L-threonine aldolase - Escherichia coli (strain K12) - ltaE gene Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. L-threo-phenylserine and L-erythro-phenylserine are also good substrates. Indicus|evm.model.PRDE01026995.1.1 Q9I755 TSSM1_PSEAE 53.165 0.993421 0.138056 tssM1 - Type VI secretion system component TssM1 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - tssM1 gene Core component of the type VI (T6SS) secretion system that plays a role in the release of toxins targeting both eukaryotic and prokaryotic species. Plays an essential role in stabilization of assembled TssK1 structure at a fixed perimembrane site. Indicus|evm.model.PRDE01027051.1.1 Q91Z83 MYH7_MOUSE 100.000 0.987013 0.0397933 Myh7 - Myosin-7 - Mus musculus (Mouse) - Myh7 gene Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Indicus|evm.model.PRDE01027065.1.1 Q0SAL1 SYL_RHOJR 78.916 0.976401 0.35873 leuS - Leucine--tRNA ligase - Rhodococcus jostii (strain RHA1) - leuS gene Indicus|evm.model.PRDE01027067.1.1 P56954 MQO_CAMJE 46.349 0.968553 0.709821 mqo - Probable malate:quinone oxidoreductase - Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) - mqo gene Catalyzes oxidation of malate to oxaloacetate in the citric acid cycle. Donates electrons to quinones of the electron transfer chain (By similarity). Indicus|evm.model.PRDE01027158.1.1 Q7ZVA6 IF4A3_DANRE 70.312 0.96962 0.972906 eif4a3 - Eukaryotic initiation factor 4A-III - Danio rerio (Zebrafish) - eif4a3 gene ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity). Involved in craniofacial development (PubMed:24360810). Indicus|evm.model.PRDE01027417.1.1 Q50201 PARB_MYCLE 56.087 0.92437 0.714715 parB - Probable chromosome-partitioning protein ParB - Mycobacterium leprae (strain TN) - parB gene Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity). Indicus|evm.model.PRDE01027467.1.1 P81066 IRX2_MOUSE 96.032 0.628141 0.419831 Irx2 - Iroquois-class homeodomain protein IRX-2 - Mus musculus (Mouse) - Irx2 gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, cell development, metanephros development, negative regulation of transcription by RNA polymerase II, neuron differentiation, proximal/distal pattern formation involved in metanephric nephron development Indicus|evm.model.PRDE01027475.1.1 Q8IED2 SMC2_PLAF7 58.173 0.504878 0.336617 MAL13P1.96 - Structural maintenance of chromosomes protein 2 - Plasmodium falciparum (isolate 3D7) - MAL13P1.96 gene May play a role in the conversion of interphase chromatin into condensed chromosomes. Indicus|evm.model.PRDE01027510.1.1 O95221 OR5F1_HUMAN 82.407 0.963964 0.353503 OR5F1 - Olfactory receptor 5F1 - Homo sapiens (Human) - OR5F1 gene Odorant receptor. Indicus|evm.model.PRDE01027515.1.1 P63350 Y2022_MYCBO 51.887 0.949772 0.497727 BQ2027_MB2022C - Uncharacterized transporter Mb2022c - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - BQ2027_MB2022C gene Probable amino-acid or metabolite transport protein. Indicus|evm.model.PRDE01027532.1.1 Q5YTQ6 TPIS_NOCFA 76.471 0.985401 0.524904 tpiA - Triosephosphate isomerase - Nocardia farcinica (strain IFM 10152) - tpiA gene Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). Indicus|evm.model.PRDE01027533.1.1 Q0SAH7 RSMG_RHOJR 65.517 0.797235 0.955947 rsmG - Ribosomal RNA small subunit methyltransferase G - Rhodococcus jostii (strain RHA1) - rsmG gene Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. Indicus|evm.model.PRDE01027607.1.1 B4RBG0 SECB_PHEZH 77.206 0.808383 1.02454 secB - Protein-export protein SecB - Phenylobacterium zucineum (strain HLK1) - secB gene One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. Indicus|evm.model.PRDE01027611.1.1 P37248 TRA8_CUPMC 57.231 0.944606 1.0118 IS1086 - Transposase for insertion sequence element IS1086 - Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) - IS1086 gene Required for the transposition of the insertion element. Indicus|evm.model.PRDE01027621.1.1 P35623 GLYC_SHEEP 53.902 0.950249 0.830579 SHMT1 - Serine hydroxymethyltransferase, cytosolic - Ovis aries (Sheep) - SHMT1 gene Interconversion of serine and glycine. Indicus|evm.model.PRDE01027657.1.1 Q3SZ90 RL13A_BOVIN 54.819 0.820652 0.906404 RPL13A - 60S ribosomal protein L13a - Bos taurus (Bovine) - RPL13A gene Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). Indicus|evm.model.PRDE01027682.1.1 Q9Y6R7 FCGBP_HUMAN 77.778 0.706349 0.0233117 FCGBP - IgGFc-binding protein precursor - Homo sapiens (Human) - FCGBP gene May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa. Indicus|evm.model.PRDE01027707.1.1 Q8NFM4 ADCY4_HUMAN 95.876 0.994845 0.18013 ADCY4 - Adenylate cyclase type 4 - Homo sapiens (Human) - ADCY4 gene Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Indicus|evm.model.PRDE01027735.1.1 Q1BBL0 SSRP_MYCSS 76.923 0.880682 1.04762 smpB - SsrA-binding protein - Mycobacterium sp. (strain MCS) - smpB gene Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. Indicus|evm.model.PRDE01027755.1.1 Q50140 DCDA_MYCLE 49.351 0.912409 0.290254 lysA - Diaminopimelate decarboxylase - Mycobacterium leprae (strain TN) - lysA gene Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. Indicus|evm.model.PRDE01027765.1.1 C1ASZ6 ASSY_RHOOB 84.416 0.962025 0.197995 argG - Argininosuccinate synthase - Rhodococcus opacus (strain B4) - argG gene Indicus|evm.model.PRDE01027915.1.1 P77364 GLXK2_ECOLI 51.049 0.934211 0.39895 glxK - Glycerate 3-kinase - Escherichia coli (strain K12) - glxK gene glycerate 2-kinase activity, glycolate catabolic process, glyoxylate catabolic process Indicus|evm.model.PRDE01027920.1.1 Q8H0S9 PSA_ARATH 45.285 0.993647 0.89128 MPA1 - Puromycin-sensitive aminopeptidase - Arabidopsis thaliana (Mouse-ear cress) - MPA1 gene Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. Plays an essential role during prophase I of meiosis. Required for correct meiotic reconbination in both male and female gametophytes. Indicus|evm.model.PRDE01027954.1.1 Q9FMJ0 P4KB1_ARATH 46.048 0.422156 0.595897 PI4KB1 - Phosphatidylinositol 4-kinase beta 1 - Arabidopsis thaliana (Mouse-ear cress) - PI4KB1 gene Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5-trisphosphate. Necessary for proper organization of the trans-Golgi network (TGN) and post-Golgi secretion in root hairs. Together with PI4KB2, required during polarized root hair expansion and pollen tube elongation. Functions redundantly with PI4KB2 upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway. Indicus|evm.model.PRDE01027973.1.1 A0R1Y7 FADA4_MYCS2 57.647 0.992188 0.659794 MSMEG_4920 - Probable acetyl-CoA acetyltransferase - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - MSMEG_4920 gene Indicus|evm.model.PRDE01027993.1.1 C1D6J9 SYV_LARHH 66.667 0.982036 0.178228 valS - Valine--tRNA ligase - Laribacter hongkongensis (strain HLHK9) - valS gene Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner. Indicus|evm.model.PRDE01028216.1.1 P36241 RL19_DROME 63.006 0.955556 0.8867 RpL19 - 60S ribosomal protein L19 - Drosophila melanogaster (Fruit fly) - RpL19 gene cytosolic large ribosomal subunit, cytosolic ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.PRDE01028319.1.1 O48917 SQD1_ARATH 63.036 0.95873 0.660377 SQD1 - UDP-sulfoquinovose synthase, chloroplastic precursor - Arabidopsis thaliana (Mouse-ear cress) - SQD1 gene Involved in the biosynthesis of sulfolipids found in thylakoid membranes. Converts UDP-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose. Indicus|evm.model.PRDE01028329.1.1 O86422 UDG_PSEAE 45.255 0.971429 0.309051 udg - UDP-glucose 6-dehydrogenase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - udg gene Indicus|evm.model.PRDE01028359.1.1 Q1GWB2 Y337_SPHAL 88.288 0.990991 0.447581 Sala_0337 - Probable transcriptional regulatory protein Sala_0337 - Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) - Sala_0337 gene Indicus|evm.model.PRDE01028365.1.1 P46725 P5CR_MYCLE 48.529 0.909091 0.486395 proC - Pyrroline-5-carboxylate reductase - Mycobacterium leprae (strain TN) - proC gene Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. Indicus|evm.model.PRDE01028526.1.1 A4TEI3 IF1_MYCGI 100.000 0.585366 1.68493 infA - Translation initiation factor IF-1 - Mycolicibacterium gilvum (strain PYR-GCK) - infA gene One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. Indicus|evm.model.PRDE01028590.1.1 A0R075 LIPA_MYCS2 81.949 0.910891 0.964968 lipA - Lipoyl synthase - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - lipA gene Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. Indicus|evm.model.PRDE01028619.1.1 F4K2E9 PRP16_ARATH 46.667 0.808664 0.220717 CUV - Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 - Arabidopsis thaliana (Mouse-ear cress) - CUV gene Involved in pre-mRNA splicing by mediating structural transitions of the spliceosome during the catalytic step. Facilitates expression of genes involved in auxin-mediated development including male-gametophyte transmission, apical-basal patterning of embryonic and gynoecium development, stamen development, phyllotactic flower positioning, and vascular development (PubMed:25384462). Also involved in root-meristem maintenance and planar polarity of root-hair positioning (PubMed:26237376). Acts as a component of RNA silencing that regulates distinct classes of endogenous small RNAs. Functions as a positive regulator of plant immunity (PubMed:25902521). Indicus|evm.model.PRDE01028657.1.1 Q8NNJ2 ODP2_CORGL 73.256 0.988439 0.256296 aceF - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - aceF gene Is essential for both 2-oxoglutarate dehydrogenase (ODH) and pyruvate dehydrogenase (PDH) activities, but AceF has exclusively transacetylase (and no transsuccinylase) activity. The lipoyl residues required for ODH activity are likely provided by AceF. Indicus|evm.model.PRDE01028672.1.1 P48594 SPB4_HUMAN 70.588 0.458716 0.279487 SERPINB4 - Serpin B4 - Homo sapiens (Human) - SERPINB4 gene May act as a protease inhibitor to modulate the host immune response against tumor cells. Indicus|evm.model.PRDE01028688.1.1 P9WPN5 CP130_MYCTU 45.139 0.878981 0.387654 cyp130 - Cytochrome P450 130 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - cyp130 gene cell wall, cholest-4-en-3-one 26-monooxygenase activity, heme binding, steroid hydroxylase activity, cholesterol catabolic process Indicus|evm.model.PRDE01028724.1.1 Q16787 LAMA3_HUMAN 84.615 0.688172 0.0279028 LAMA3 - Laminin subunit alpha-3 precursor - Homo sapiens (Human) - LAMA3 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Indicus|evm.model.PRDE01028876.1.1 Q13263 TIF1B_HUMAN 94.681 0.989362 0.112575 TRIM28 - Transcription intermediary factor 1-beta - Homo sapiens (Human) - TRIM28 gene Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity). Indicus|evm.model.PRDE01029057.1.1 B4R9C5 RL20_PHEZH 80.508 0.983051 1 rplT - 50S ribosomal protein L20 - Phenylobacterium zucineum (strain HLK1) - rplT gene Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. Indicus|evm.model.PRDE01029106.1.1 B2FKE2 AZOR_STRMK 66.327 0.923077 0.533333 azoR - FMN-dependent NADH:quinone oxidoreductase - Stenotrophomonas maltophilia (strain K279a) - azoR gene Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. Indicus|evm.model.PRDE01029189.1.1 Q9BXJ3 C1QT4_HUMAN 94.118 0.423729 0.358663 C1QTNF4 - Complement C1q tumor necrosis factor-related protein 4 precursor - Homo sapiens (Human) - C1QTNF4 gene May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity). Indicus|evm.model.PRDE01029233.1.1 P9WNU5 DPO1_MYCTU 62.987 0.921687 0.183628 polA - DNA polymerase I - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - polA gene In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. Indicus|evm.model.PRDE01029271.1.1 P0ABI8 CYOB_ECOLI 74.336 0.99705 0.511312 cyoB - Cytochrome bo(3) ubiquinol oxidase subunit 1 - Escherichia coli (strain K12) - cyoB gene Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron. Protons are probably pumped via D- and K- channels found in this subunit (PubMed:11017202). Indicus|evm.model.PRDE01029367.1.1 Q47NX7 ARC_THEFY 62.550 0.908425 0.467466 arc - Proteasome-associated ATPase - Thermobifida fusca (strain YX) - arc gene ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Indicus|evm.model.PRDE01029392.1.1 P9WNX3 SERA_MYCTU 73.656 0.994624 0.352273 serA - D-3-phosphoglycerate dehydrogenase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - serA gene Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. Indicus|evm.model.PRDE01029395.1.1 O86308 RPF_MICLU 98.750 0.9875 0.358744 rpf - Resuscitation-promoting factor Rpf precursor - Micrococcus luteus - rpf gene Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity. In pM quantities promotes the resuscitation and growth of dormant, nongrowing cells from M.luteus in addition to Mycobacterium tuberculosis, M.avium, M.bovis, M.kansaii and M.smegmatis. Hydrolyzes endogeneous cell walls, peptidoglycan preparations from Mycobacterium tuberculosis and M.smegmatis as well as an artificial lysozyme substrate 4-methylumbelliferyl-beta-D-N,N',N''-triacetylchitotrioside (MUF tri-NAG). Overexpression in E.coli (when the enzyme is targeted to the periplasm) causes cell lysis. Indicus|evm.model.PRDE01029417.1.1 P9WN15 Y2006_MYCTU 45.274 0.952381 0.158252 Rv2006 - Uncharacterized glycosyl hydrolase Rv2006 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv2006 gene cell wall, extracellular region, plasma membrane, hydrolase activity, hydrolyzing O-glycosyl compounds, carbohydrate metabolic process Indicus|evm.model.PRDE01029430.1.1 Q8KCM7 SYK_CHLTE 62.595 0.969925 0.260274 lysS - Lysine--tRNA ligase - Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) - lysS gene Indicus|evm.model.PRDE01029435.1.1 P9WNY9 MENJ_MYCTU 60.274 0.966667 0.367647 menJ - Menaquinone reductase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - menJ gene Catalyzes the reduction of a single double bond in the isoprenoid tail of menaquinone (MK-9) in M.tuberculosis, likely the beta-isoprene unit, forming the predominant form of menaquinone found in mycobacteria, MK-9(II-H2). Is required for M.tuberculosis survival in host macrophages. Indicus|evm.model.PRDE01029552.1.1 P24580 YI74_BURM1 62.025 0.847826 1.05747 Bmul_4720 - Insertion element IS407 uncharacterized 10.0 kDa protein - Burkholderia multivorans (strain ATCC 17616 / 249) - Bmul_4720 gene Indicus|evm.model.PRDE01029553.1.1 B8H535 NUSB_CAUVN 69.841 0.976562 0.85906 nusB - Transcription antitermination protein NusB - Caulobacter vibrioides (strain NA1000 / CB15N) - nusB gene Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. Indicus|evm.model.PRDE01029659.1.1 Q9MAB3 NOP5B_ARATH 53.968 0.981481 0.709193 NOP5-2 - Probable nucleolar protein 5-2 - Arabidopsis thaliana (Mouse-ear cress) - NOP5-2 gene Required for 60S ribosomal subunit biogenesis. Indicus|evm.model.PRDE01029841.1.1 Q6ANL3 UBIE_DESPS 61.290 0.983871 0.252033 ubiE - Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE - Desulfotalea psychrophila (strain LSv54 / DSM 12343) - ubiE gene Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). Indicus|evm.model.PRDE01029842.1.1 Q5Z3N4 HTPG_NOCFA 61.905 0.924915 0.449387 htpG - Chaperone protein HtpG - Nocardia farcinica (strain IFM 10152) - htpG gene Molecular chaperone. Has ATPase activity. Indicus|evm.model.PRDE01029891.1.1 B1XWM8 GUAC_LEPCP 49.524 0.978193 0.987692 guaC - GMP reductase - Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) - guaC gene Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Indicus|evm.model.PRDE01029927.1.1 I6YC03 EPHB_MYCTU 50.847 0.337209 0.483146 ephB - Epoxide hydrolase B - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ephB gene Could be involved in detoxification of extraneous host-cell epoxides. Catalyzes the hydrolysis of epoxide-containing substrates. Indicus|evm.model.PRDE01030066.1.1 Q82DE3 FBIB_STRAW 55.102 0.76 0.295508 fbiB - Bifunctional F420 biosynthesis protein FbiB - Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) - fbiB gene Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0. Indicus|evm.model.PRDE01030075.1.1 A0PM50 MFTD_MYCUA 69.663 0.846154 0.266667 mftD - Pre-mycofactocin synthase - Mycobacterium ulcerans (strain Agy99) - mftD gene Involved in the biosynthesis of the enzyme cofactor mycofactocin (MFT). Catalyzes the oxidative deamination of AHDP (3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one), forming an alpha-keto amide moiety on the resulting molecule, which is called pre-mycofactocin (PMFT). This reaction occurs via a 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one intermediate, which converts to PMFT. The alpha-keto amide moiety is the redox-active center for the redox activity of mycofactocin. Indicus|evm.model.PRDE01030077.1.2 B2GHR6 GLGC_KOCRD 74.085 0.987879 0.797101 glgC - Glucose-1-phosphate adenylyltransferase - Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201) - glgC gene Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. Indicus|evm.model.PRDE01030086.1.2 Q9LZF6 CD48E_ARATH 60.197 0.866044 0.396296 CDC48E - Cell division control protein 48 homolog E - Arabidopsis thaliana (Mouse-ear cress) - CDC48E gene Probably functions in cell division and growth processes. Interacts with certain SNAREs as part of specialized membrane fusion events where vesicles from the same organelle fuse (homotypic fusion) (By similarity). Indicus|evm.model.PRDE01030114.1.1 Q5Z048 SYV_NOCFA 69.286 0.939189 0.165733 valS - Valine--tRNA ligase - Nocardia farcinica (strain IFM 10152) - valS gene Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner. Indicus|evm.model.PRDE01030139.1.1 C5CB68 Y1499_MICLC 97.727 0.796296 0.0515759 Mlut_14990 - UPF0182 protein Mlut_14990 - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - Mlut_14990 gene Indicus|evm.model.PRDE01030157.1.1 P06231 NOE4_RHIML 48.810 0.902703 0.461347 nodE - Nodulation protein E - Rhizobium meliloti (Ensifer meliloti) - nodE gene Proposed to synthesize NOD factor fatty acyl chain. Involved in the synthesis of a highly unsaturated fatty acid moiety, which forms part of a lipo-oligosaccharide that is responsible for host specificity. Indicus|evm.model.PRDE01030164.1.1 Q8RQP4 DHE4_COREF 67.742 0.984 0.279642 gdh - NADP-specific glutamate dehydrogenase - Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) - gdh gene Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. Indicus|evm.model.PRDE01030213.1.1 B0RDF9 NADD_CLAMS 78.289 0.777202 0.965 nadD - Probable nicotinate-nucleotide adenylyltransferase - Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) - nadD gene Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). Indicus|evm.model.PRDE01030242.1.1 P46701 PURK_MYCLE 56.436 0.951923 0.236902 purK - N5-carboxyaminoimidazole ribonucleotide synthase - Mycobacterium leprae (strain TN) - purK gene Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). Indicus|evm.model.PRDE01030428.1.1 P21345 GLTP_ECOLI 78.261 0.876923 0.297483 gltP - Proton/glutamate-aspartate symporter - Escherichia coli (strain K12) - gltP gene Catalyzes the proton-dependent, binding-protein-independent transport of glutamate and aspartate. Indicus|evm.model.PRDE01030444.1.1 Q8NS49 MCTC_CORGL 65.327 0.994709 0.343013 mctC - Monocarboxylic acid transporter - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - mctC gene Acts as a secondary carrier for acetate, propionate and pyruvate. Has high affinity for acetate and propionate and lower affinity for pyruvate. Driven by the electrochemical proton potential. Indicus|evm.model.PRDE01030575.1.1 Q9R190 MTA2_MOUSE 48.980 0.174721 0.402695 Mta2 - Metastasis-associated protein MTA2 - Mus musculus (Mouse) - Mta2 gene May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. Indicus|evm.model.PRDE01030582.1.1 B8GVF3 QUEA_CAUVN 78.873 0.992958 0.387978 queA - S-adenosylmethionine:tRNA ribosyltransferase-isomerase - Caulobacter vibrioides (strain NA1000 / CB15N) - queA gene Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). Indicus|evm.model.PRDE01030629.1.1 Q0S0L6 RPOZ_RHOJR 78.333 0.967213 0.60396 rpoZ - DNA-directed RNA polymerase subunit omega - Rhodococcus jostii (strain RHA1) - rpoZ gene Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. Indicus|evm.model.PRDE01030714.1.1 Q4JXA4 MURA_CORJK 66.469 0.982456 0.818182 murA - UDP-N-acetylglucosamine 1-carboxyvinyltransferase - Corynebacterium jeikeium (strain K411) - murA gene Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Indicus|evm.model.PRDE01030817.1.1 Q5BP74 KC1D_XENLA 99.107 0.982301 0.272289 csnk1d - Casein kinase I isoform delta - Xenopus laevis (African clawed frog) - csnk1d gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Isoform 1 can phosphorylate a large number of proteins. Isoform 2 has no kinase activity. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). Indicus|evm.model.PRDE01030842.1.2 O30569 MTS1_RHIME 52.830 0.33121 0.417553 smeIM - Modification methylase SmeI - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - smeIM gene This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. Ccrm-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Indicus|evm.model.PRDE01030902.1.1 Q9IAM7 MRE11_CHICK 54.545 0.242537 0.382857 MRE11 - Double-strand break repair protein MRE11 - Gallus gallus (Chicken) - MRE11 gene Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity). Indicus|evm.model.PRDE01030981.1.1 Q80T03 MUC6_MOUSE 73.333 0.983333 0.0210526 Muc6 - Mucin-6 precursor - Mus musculus (Mouse) - Muc6 gene May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Indicus|evm.model.PRDE01031001.1.1 P9WGX3 Y1407_MYCTU 62.609 0.991304 0.251641 Rv1407 - Putative methyltransferase Rv1407 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1407 gene May act as RNA methyltransferase. Indicus|evm.model.PRDE01031049.1.2 Q93QI2 CH60_RHOHA 90.106 0.930693 0.560074 groL - 60 kDa chaperonin - Rhodococcus hoagii - groL gene Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Indicus|evm.model.PRDE01031051.1.2 P9WI83 PKNA_MYCTU 57.639 0.985714 0.324826 pknA - Serine/threonine-protein kinase PknA - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - pknA gene Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host (PubMed:25713147). Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422 (PubMed:15985609, PubMed:16817899, PubMed:19121323, PubMed:20066037, PubMed:21190553, PubMed:21423706). Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibition of processing of pre-PrcB and assembly of the proteasome complex, and thereby enhances the mycobacterial resistance to H(2)O(2); PknA thus plays an important role in the oxidative stress response by impeding the formation of holo-proteasome in M.tuberculosis under H(2)O(2) stress (PubMed:25224505). Shows a strong preference for Thr versus Ser as the phosphoacceptor. Indicus|evm.model.PRDE01031155.1.1 P9WIK3 CYSH_MYCTU 56.897 0.527778 0.425197 cysH - Adenosine 5'-phosphosulfate reductase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - cysH gene Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor. Indicus|evm.model.PRDE01031186.1.1 P9WQ75 ILVE_MYCTU 59.677 0.97619 0.342391 ilvE - Branched-chain-amino-acid aminotransferase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ilvE gene Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosynthesis of branchedchain amino acids. The amino acids can be ranked in the following order with respect to their efficiency as amino donor: Leu > Ile > Val. Indicus|evm.model.PRDE01031201.1.1 P38545 RAN_PLAFA 79.208 0.75 1.25234 GTP-binding nuclear protein Ran - Plasmodium falciparum Indicus|evm.model.PRDE01031256.1.1 P98002 COX1B_PARDE 86.916 0.990698 0.385305 ctaDII - Cytochrome c oxidase subunit 1-beta - Paracoccus denitrificans - ctaDII gene Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer. Indicus|evm.model.PRDE01031421.1.1 O06769 NCASE_MYCTU 49.004 0.988048 0.394035 Rv0669c - Neutral ceramidase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv0669c gene Catalyzes the cleavage of the N-acyl linkage of the ceramides (Cers) to yield sphingosine (Sph) and free fatty acid. Also catalyzes the synthesis of Cers from Sph and fatty acid. Cers containning C6-C24 fatty acids are well hydrolyzed, and Cers with mono unsaturated fatty acids are much more hydrolyzed than those with saturated fatty acids. Indicus|evm.model.PRDE01031453.1.1 P9WN79 GLPD2_MYCTU 49.544 0.990937 0.565812 glpD2 - Glycerol-3-phosphate dehydrogenase 2 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - glpD2 gene plasma membrane, glycerol-3-phosphate dehydrogenase (quinone) activity, glycerol-3-phosphate catabolic process Indicus|evm.model.PRDE01031493.1.1 O00204 ST2B1_HUMAN 83.721 0.424242 0.271233 SULT2B1 - Sulfotransferase 2B1 - Homo sapiens (Human) - SULT2B1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:19589875, PubMed:12145317). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:9799594, PubMed:12145317, PubMed:21855633, PubMed:16855051). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). Indicus|evm.model.PRDE01031607.1.1 A0JR38 NHAA_ARTS2 61.078 0.976331 0.366594 nhaA - Na(+)/H(+) antiporter NhaA - Arthrobacter sp. (strain FB24) - nhaA gene Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Indicus|evm.model.PRDE01031617.1.1 P9WNY5 MMSB_MYCTU 70.115 0.550955 1.06803 mmsB - Probable 3-hydroxyisobutyrate dehydrogenase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - mmsB gene oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Indicus|evm.model.PRDE01031681.1.1 C4K0C9 RF1_RICPU 69.892 0.893204 0.290141 prfA - Peptide chain release factor 1 - Rickettsia peacockii (strain Rustic) - prfA gene Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. Indicus|evm.model.PRDE01031713.1.1 O32507 GABD_DEIRA 52.800 0.756098 0.343816 ssdA - Succinate-semialdehyde dehydrogenase [NADP(+)] - Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) - ssdA gene Catalyzes the NADP(+) dependent oxidation of succinate semialdehyde to succinate. Indicus|evm.model.PRDE01031747.1.1 O07436 LDT4_MYCTU 52.326 0.965909 0.240437 Rv0192 - L,D-transpeptidase 4 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv0192 gene Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Indicus|evm.model.PRDE01031749.1.1 P9WNT7 DPO3A_MYCTU 50.532 0.994595 0.15625 dnaE1 - DNA polymerase III subunit alpha - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - dnaE1 gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity). Indicus|evm.model.PRDE01031850.1.1 C5C958 FOLD_MICLC 93.296 0.988889 0.594059 folD - Bifunctional protein FolD - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - folD gene Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Indicus|evm.model.PRDE01031858.1.1 P46405 RS12_PIG 58.559 0.769231 1.08333 RPS12 - 40S ribosomal protein S12 - Sus scrofa (Pig) - RPS12 gene cytosolic small ribosomal subunit, structural constituent of ribosome Indicus|evm.model.PRDE01031952.1.1 Q4UEQ6 P23_THEAN 92.140 0.991266 1 TA13810 - 23 kDa piroplasm membrane protein precursor - Theileria annulata - TA13810 gene Indicus|evm.model.PRDE01032006.1.1 Q740M4 COAE_MYCPA 54.622 0.861314 0.336609 coaE - Dephospho-CoA kinase - Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) - coaE gene Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Indicus|evm.model.PRDE01032070.1.2 A1AXZ2 SFGH_PARDP 48.000 0.935065 0.275986 fghA - S-formylglutathione hydrolase - Paracoccus denitrificans (strain Pd 1222) - fghA gene Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable). Indicus|evm.model.PRDE01032093.1.1 P9WH11 RMLC_MYCTU 52.326 0.745614 0.564356 rmlC - dTDP-4-dehydrorhamnose 3,5-epimerase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - rmlC gene Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage. Indicus|evm.model.PRDE01032136.1.1 Q05739 THIO_STRCL 67.021 0.861111 1.00935 trxA - Thioredoxin - Streptomyces clavuligerus - trxA gene Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Indicus|evm.model.PRDE01032232.1.1 P9WQN1 Y2559_MYCTU 60.584 0.712042 0.422566 Rv2559c - Uncharacterized AAA domain-containing protein Rv2559c - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv2559c gene enzyme activator activity, single-stranded DNA helicase activity, DNA-dependent DNA replication, regulation of DNA repair Indicus|evm.model.PRDE01032263.1.1 Q7X9V2 PIE1_ARATH 54.545 0.296804 0.106569 PIE1 - Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1 - Arabidopsis thaliana (Mouse-ear cress) - PIE1 gene Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Probable DNA-dependent ATPase. Not involved in the repression of FLC in gametophytes, but required for the reactivation of FLC in early embryos and for the maintenance of full activation of FLC in late embryos. Indicus|evm.model.PRDE01032265.1.1 O33804 MURF_STRTO 51.562 0.473684 0.298206 murF - UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase - Streptomyces toyocaensis - murF gene Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. Indicus|evm.model.PRDE01032330.1.1 P75892 RUTG_ECOLI 50.376 0.963504 0.309955 rutG - Putative pyrimidine permease RutG - Escherichia coli (strain K12) - rutG gene May function as a proton-driven pyrimidine uptake system. Indicus|evm.model.PRDE01032422.1.1 Q98D88 YIDC_RHILO 58.696 0.412844 0.180763 yidC - Membrane protein insertase YidC - Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) - yidC gene Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. Indicus|evm.model.PRDE01032456.1.1 P76318 YEDK_ECOLI 52.475 0.882883 0.5 yedK - Abasic site processing protein YedK - Escherichia coli (strain K12) - yedK gene Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877). Recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235915, PubMed:31504793). May act as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). Indicus|evm.model.PRDE01032483.1.1 Q9A3H4 TOLB_CAUVC 73.203 0.858757 0.409722 tolB - Tol-Pal system protein TolB precursor - Caulobacter vibrioides (strain ATCC 19089 / CB15) - tolB gene Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Indicus|evm.model.PRDE01032518.1.1 P9WGM3 PDTAR_MYCTU 64.234 0.985507 0.673171 pdtaR - Probable transcriptional regulatory protein PdtaR - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - pdtaR gene Member of the two-component regulatory system PdtaR/PdtaS. Indicus|evm.model.PRDE01032558.1.1 Q96291 BAS1A_ARATH 47.027 0.962963 0.710526 BAS1 - 2-Cys peroxiredoxin BAS1, chloroplastic precursor - Arabidopsis thaliana (Mouse-ear cress) - BAS1 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. May be an antioxidant enzyme particularly in the developing shoot and photosynthesizing leaf. Indicus|evm.model.PRDE01032809.1.1 Q32L93 GMPR2_BOVIN 97.248 0.981818 0.316092 GMPR2 - GMP reductase 2 - Bos taurus (Bovine) - GMPR2 gene Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity). Indicus|evm.model.PRDE01032821.1.1 A9WP46 RIMM_RENSM 50.442 0.8 0.771429 rimM - Ribosome maturation factor RimM - Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) - rimM gene An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes. Indicus|evm.model.PRDE01032914.1.1 Q66L51 COQ5_DANRE 55.385 0.927536 0.211009 coq5 - 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor - Danio rerio (Zebrafish) - coq5 gene Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). Indicus|evm.model.PRDE01033204.1.1 Q54R47 GCDH_DICDI 53.247 0.571429 0.316667 gcdh - Glutaryl-CoA dehydrogenase, mitochondrial precursor - Dictyostelium discoideum (Slime mold) - gcdh gene mitochondrion, fatty-acyl-CoA binding, flavin adenine dinucleotide binding, glutaryl-CoA dehydrogenase activity, fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty-acyl-CoA biosynthetic process Indicus|evm.model.PRDE01033879.1.1 P26832 Y188_CLOPE 47.222 0.683871 0.525424 CPE0188 - Uncharacterized protein CPE0188 - Clostridium perfringens (strain 13 / Type A) - CPE0188 gene Indicus|evm.model.PRDE01034019.1.1 Q6F6Q0 ILVD2_ACIAD 89.076 0.991597 0.212121 ilvD2 - Dihydroxy-acid dehydratase 2 - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - ilvD2 gene Indicus|evm.model.PRDE01034048.1.1 Q02543 RL18A_HUMAN 57.658 0.982143 0.636364 RPL18A - 60S ribosomal protein L18a - Homo sapiens (Human) - RPL18A gene cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing Indicus|evm.model.PRDE01034082.1.1 Q48446 YC18_KLEPN 55.357 0.964602 0.664706 Uncharacterized 18.9 kDa protein in cps region - Klebsiella pneumoniae Indicus|evm.model.PRDE01034100.1.1 P21323 YR7I_ECOLX 100.000 0.895455 1.11111 Putative uncharacterized protein ORFI in retron EC67 - Escherichia coli Indicus|evm.model.PRDE01034121.1.1 Q1H031 SUCC_METFK 52.571 0.873737 0.511628 sucC - Succinate--CoA ligase [ADP-forming] subunit beta - Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) - sucC gene Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Indicus|evm.model.PRDE01034164.1.1 P0AE45 YTFL_ECOLI 59.394 0.987952 0.371365 ytfL - UPF0053 inner membrane protein YtfL - Escherichia coli (strain K12) - ytfL gene plasma membrane Indicus|evm.model.PRDE01034339.1.1 A0A0N8YGA2 ANOR_ACINO 49.153 0.232932 1.04622 anoR - Transcriptional activator protein AnoR - Acinetobacter nosocomialis - anoR gene Positively regulates the expression of anoI. Required for biofilm formation and motility. Probably part of a quorum-sensing system with AnoI. Indicus|evm.model.PRDE01034391.1.1 P23100 XYLY_PSEPU 59.420 0.871795 0.481481 xylY - Toluate 1,2-dioxygenase subunit beta - Pseudomonas putida - xylY gene Indicus|evm.model.PRDE01034405.1.1 P9WFP3 Y1842_MYCTU 46.479 0.948529 0.298901 Rv1842c - UPF0053 protein Rv1842c - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1842c gene Indicus|evm.model.PRDE01034508.1.1 P9WQL5 MKL_MYCTU 60.784 0.990196 0.284123 mkl - Probable ribonucleotide transport ATP-binding protein mkl - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - mkl gene Not known, could be involved in the transport of ribonucleotides. Indicus|evm.model.PRDE01034581.1.1 Q61672 S29A2_MOUSE 87.000 0.811475 0.267544 Slc29a2 - Equilibrative nucleoside transporter 2 - Mus musculus (Mouse) - Slc29a2 gene Mediates equilibrative transport of purine and pyrimidine nucleosides, and the purine base hypoxanthine. Indicus|evm.model.PRDE01034721.1.1 Q1RDK0 EFEU_ECOUT 95.000 0.951807 0.300725 efeU - Ferrous iron permease EfeU - Escherichia coli (strain UTI89 / UPEC) - efeU gene Uptake of Fe(2+) ions across the membrane. Indicus|evm.model.PRDE01034770.1.1 Q4U9M9 104K_THEAN 96.279 0.990741 0.241881 TA08425 - 104 kDa microneme/rhoptry antigen precursor - Theileria annulata - TA08425 gene Indicus|evm.model.PRDE01034802.1.1 P0A156 AHPF_PSEPU 72.458 0.983264 0.459615 ahpF - Alkyl hydroperoxide reductase subunit F - Pseudomonas putida - ahpF gene Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein. Indicus|evm.model.PRDE01034859.1.1 Q6FED0 MURA_ACIAD 91.571 0.996169 0.624402 murA - UDP-N-acetylglucosamine 1-carboxyvinyltransferase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - murA gene Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Indicus|evm.model.PRDE01034930.1.1 Q0RDX2 MIAB_FRAAA 82.692 0.944444 0.108652 miaB - tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase - Frankia alni (strain ACN14a) - miaB gene Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. Indicus|evm.model.PRDE01034930.1.2 O50488 RECX_STRCO 65.854 0.784314 0.271277 recX - Regulatory protein RecX - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - recX gene Modulates RecA activity. Indicus|evm.model.PRDE01035120.1.1 O53871 Y0859_MYCTU 66.667 0.977099 0.325062 fadA - Putative acyltransferase Rv0859 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - fadA gene cell wall, plasma membrane, acetyl-CoA C-acetyltransferase activity, fatty acid beta-oxidation Indicus|evm.model.PRDE01035232.1.1 Q82B58 Y5847_STRAW 46.552 0.678571 0.149733 SAV_5847 - Putative ABC transporter ATP-binding protein SAV_5847 - Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) - SAV_5847 gene Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). Indicus|evm.model.PRDE01035236.1.1 Q9I425 CYOC_PSEAE 65.909 0.393665 1.05742 cyoC - Cytochrome bo(3) ubiquinol oxidase subunit 3 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - cyoC gene Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). Indicus|evm.model.PRDE01035310.1.1 A0R7G2 PBP1A_MYCS2 57.229 0.976048 0.425478 ponA1 - Penicillin-binding protein 1A - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - ponA1 gene Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity). Indicus|evm.model.PRDE01035372.1.1 P94605 GYRA_CLOAB 73.214 0.988166 0.203614 gyrA - DNA gyrase subunit A - Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) - gyrA gene A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. Indicus|evm.model.PRDE01035495.1.1 A0R7G6 INO1_MYCS2 89.759 0.993976 0.4573 ino1 - Inositol-3-phosphate synthase - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - ino1 gene Catalyzes the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate. Indicus|evm.model.PRDE01035503.1.1 P19772 YIA2_MYCTX 59.649 0.636364 1.49153 Insertion element IS986 uncharacterized 6.6 kDa protein - Mycobacterium tuberculosis Indicus|evm.model.PRDE01035522.1.1 Q48449 YC03_KLEPN 85.366 0.987879 0.327381 Uncharacterized 55.8 kDa protein in cps region - Klebsiella pneumoniae Indicus|evm.model.PRDE01035747.1.1 A0QSG1 RL5_MYCS2 89.209 0.958333 0.770053 rplE - 50S ribosomal protein L5 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - rplE gene This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. Indicus|evm.model.PRDE01035769.1.1 Q56108 NRDH_SALTY 45.714 0.896104 0.950617 nrdH - Glutaredoxin-like protein NrdH - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - nrdH gene Electron transport system for the ribonucleotide reductase system NrdEF. Indicus|evm.model.PRDE01035807.1.1 O33730 Y1503_SHEFN 67.241 0.982955 0.604811 Sfri_1503 - Uncharacterized oxidoreductase Sfri_1503 - Shewanella frigidimarina (strain NCIMB 400) - Sfri_1503 gene Indicus|evm.model.PRDE01035842.1.1 Q86K32 UBE2N_DICDI 67.188 0.940741 0.876623 ube2n - Probable ubiquitin-conjugating enzyme E2 N - Dictyostelium discoideum (Slime mold) - ube2n gene The ube2v/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Indicus|evm.model.PRDE01035855.1.1 L7N689 TRCR_MYCTU 48.413 0.960938 0.498054 trcR - Transcriptional regulatory protein TrcR - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - trcR gene Member of the two-component regulatory system TrcS/TrcR (PubMed:10089160, PubMed:11914351). Activates its own expression by binding specifically to the AT-rich sequence of the trcR promoter region (PubMed:11914351). Also negatively regulates the expression of Rv1057 by binding to an AT-rich sequences within the Rv1057 upstream sequence (PubMed:16352831, PubMed:22099420). The TrcR-TrcS regulatory system may act as a transition regulatory system involved in adapting to an intracellular environment and transitioning from latency to reactivation (PubMed:11914351). Indicus|evm.model.PRDE01035940.1.1 Q967G1 RS17_THEAN 100.000 0.154412 1.03817 RPS17 - 40S ribosomal protein S17 - Theileria annulata - RPS17 gene Indicus|evm.model.PRDE01036174.1.1 A2RKA7 NUPA_LACLM 47.248 0.995392 0.428854 nupA - Nucleoside import ATP-binding protein NupA - Lactococcus lactis subsp. cremoris (strain MG1363) - nupA gene Part of an ABC transporter complex involved in the uptake of all common nucleosides (PubMed:20595258). Responsible for energy coupling to the transport system (Probable). Indicus|evm.model.PRDE01036222.1.1 A0JXZ6 ILVC_ARTS2 73.684 0.993421 0.445748 ilvC - Ketol-acid reductoisomerase (NADP(+)) - Arthrobacter sp. (strain FB24) - ilvC gene Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. Indicus|evm.model.PRDE01036305.1.1 A6WC96 HIS6_KINRD 78.756 0.994819 0.750973 hisF - Imidazole glycerol phosphate synthase subunit HisF - Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) - hisF gene IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. Indicus|evm.model.PRDE01036316.1.1 C5CAE0 COAD_MICLC 93.023 0.944444 0.573248 coaD - Phosphopantetheine adenylyltransferase - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - coaD gene Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Indicus|evm.model.PRDE01036417.1.1 Q91757 GSK3B_XENLA 49.049 0.796353 0.783333 gsk3b - Glycogen synthase kinase-3 beta - Xenopus laevis (African clawed frog) - gsk3b gene Plays a role in the organization of the formation of the main body axis of developing embryo. Acts as an inhibitor of differentiation of primary neurons. Inhibits the ability of ectopically expressed NEUROD1 and other bHLH factors to promote early retinal cell differentiation. May participate in the Wnt signaling pathway. May regulate the circadian clock via phosphorylation of the major clock components. Indicus|evm.model.PRDE01036519.1.1 Q9SY09 SMD1B_ARATH 63.918 0.761905 1.08621 SMD1B - Small nuclear ribonucleoprotein SmD1b - Arabidopsis thaliana (Mouse-ear cress) - SMD1B gene Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs. Indicus|evm.model.PRDE01036677.1.1 Q12C33 MSBA_POLSJ 50.685 0.63964 0.188455 msbA - ATP-dependent lipid A-core flippase - Polaromonas sp. (strain JS666 / ATCC BAA-500) - msbA gene Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. Indicus|evm.model.PRDE01036990.1.1 Q48P40 MSBA_PSE14 69.231 0.944444 0.09 msbA - ATP-dependent lipid A-core flippase - Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) - msbA gene Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. Indicus|evm.model.PRDE01037149.1.1 A6TD49 CYSJ_KLEP7 98.947 0.989474 0.158598 cysJ - Sulfite reductase [NADPH] flavoprotein alpha-component - Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) - cysJ gene Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Indicus|evm.model.PRDE01037174.1.1 P9WG13 MODB_MYCTU 65.934 0.473684 0.719697 modB - Molybdenum transport system permease protein ModB - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - modB gene Part of the binding-protein-dependent transport system ModABCD for molybdenum; probably responsible for the translocation of the substrate across the membrane. Indicus|evm.model.PRDE01037210.1.1 Q9UKV5 AMFR_HUMAN 85.057 0.988506 0.135303 AMFR - E3 ubiquitin-protein ligase AMFR - Homo sapiens (Human) - AMFR gene E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Indicus|evm.model.PRDE01037238.1.1 P0ADC3 LOLC_ECOLI 88.745 0.982906 0.586466 lolC - Lipoprotein-releasing system transmembrane protein LolC - Escherichia coli (strain K12) - lolC gene Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA. Indicus|evm.model.PRDE01037477.1.1 Q9RL35 NPD1_STRCO 60.714 0.628788 0.441472 cobB1 - NAD-dependent protein deacetylase 1 - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - cobB1 gene NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Indicus|evm.model.PRDE01037645.1.1 P58114 Y3178_CAUVC 65.972 0.993007 0.496528 CC_3178 - Pirin-like protein CC_3178 - Caulobacter vibrioides (strain ATCC 19089 / CB15) - CC_3178 gene Indicus|evm.model.PRDE01037658.1.1 P33640 RLUD_PSEAE 51.938 0.64 0.625 rluD - Ribosomal large subunit pseudouridine synthase D - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - rluD gene Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA. Indicus|evm.model.PRDE01037660.1.1 Q962T1 RL32_SPOFR 56.863 0.971154 0.776119 RpL32 - 60S ribosomal protein L32 - Spodoptera frugiperda (Fall armyworm) - RpL32 gene Indicus|evm.model.PRDE01037676.1.1 C5C878 SYS_MICLC 96.528 0.986207 0.339578 serS - Serine--tRNA ligase - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - serS gene Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). Indicus|evm.model.PRDE01037749.1.1 Q8PK23 SYC_XANAC 79.412 0.985294 0.142857 cysS - Cysteine--tRNA ligase - Xanthomonas axonopodis pv. citri (strain 306) - cysS gene Indicus|evm.model.PRDE01037835.1.1 C4ZBD8 COBQ_AGARV 61.475 0.968 0.249501 cobQ - Cobyric acid synthase - Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / VPI 0990) - cobQ gene Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Indicus|evm.model.PRDE01037883.1.1 Q1GTW7 ILVD_SPHAL 86.667 0.551402 0.172859 ilvD - Dihydroxy-acid dehydratase - Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) - ilvD gene Indicus|evm.model.PRDE01037883.1.2 Q2KZT7 ILVD_BORA1 89.552 0.956522 0.11165 ilvD - Dihydroxy-acid dehydratase - Bordetella avium (strain 197N) - ilvD gene Indicus|evm.model.PRDE01038001.1.1 A8AY22 HIS2_STRGC 76.364 0.885246 0.586538 hisE - Phosphoribosyl-ATP pyrophosphatase - Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288) - hisE gene Indicus|evm.model.PRDE01038186.1.1 Q8A988 SYP_BACTN 74.126 0.993007 0.287726 proS - Proline--tRNA ligase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - proS gene Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Indicus|evm.model.PRDE01038213.1.1 Q4UFP0 FEN1_THEAN 97.688 0.934959 0.729249 FEN1 - Flap endonuclease 1 - Theileria annulata - FEN1 gene Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. Indicus|evm.model.PRDE01038215.1.1 P9WPM7 CP136_MYCTU 53.535 0.858407 0.229675 cyp136 - Putative cytochrome P450 136 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - cyp136 gene oxidoreductase activity, sterol metabolic process Indicus|evm.model.PRDE01038222.1.1 Q1RML7 MAK16_BOVIN 55.932 0.690476 0.281879 MAK16 - Protein MAK16 homolog - Bos taurus (Bovine) - MAK16 gene nucleolus, preribosome, large subunit precursor, maturation of 5.8S rRNA, maturation of LSU-rRNA Indicus|evm.model.PRDE01038250.1.1 Q55790 Y074_SYNY3 64.815 0.993789 0.335417 slr0074 - UPF0051 protein slr0074 - Synechocystis sp. (strain PCC 6803 / Kazusa) - slr0074 gene Indicus|evm.model.PRDE01038416.1.1 Q11NV4 SYI_CYTH3 73.469 0.97 0.0900901 ileS - Isoleucine--tRNA ligase - Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465) - ileS gene Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Indicus|evm.model.PRDE01038470.1.1 C5CC70 RPOC_MICLC 97.500 0.868613 0.105547 rpoC - DNA-directed RNA polymerase subunit beta' - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - rpoC gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01038527.1.1 Q9SZV3 FOLM_ARATH 46.903 0.916667 0.216606 MitHPPK/DHPS - Folate synthesis bifunctional protein, mitochondrial precursor - Arabidopsis thaliana (Mouse-ear cress) - MitHPPK/DHPS gene Catalyzes the first two consecutive steps of tetrahydrofolate biosynthesis. Indicus|evm.model.PRDE01038560.1.1 Q9S4W7 YUBI_ECOLI 63.291 0.975 0.567376 yubI - Putative antirestriction protein YubI - Escherichia coli (strain K12) - yubI gene Indicus|evm.model.PRDE01038591.1.1 O29028 TRPB2_ARCFU 59.459 0.820225 0.204598 trpB2 - Tryptophan synthase beta chain 2 - Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) - trpB2 gene The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. Indicus|evm.model.PRDE01038595.1.2 A8GM76 SECF_RICAH 47.761 0.758621 0.282468 secF - Protein translocase subunit SecF - Rickettsia akari (strain Hartford) - secF gene Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. Indicus|evm.model.PRDE01038691.1.1 A6L3G1 SECA_BACV8 66.061 0.987879 0.150273 secA - Protein translocase subunit SecA - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - secA gene Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Indicus|evm.model.PRDE01038709.1.1 A0R2B1 KGD_MYCS2 71.739 0.996283 0.219234 kgd - Multifunctional 2-oxoglutarate metabolism enzyme - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - kgd gene Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which spontaneously decarboxylates to form 5-hydroxylevulinate (HLA). And is also a component of the 2-oxoglutarate dehydrogenase (ODH) complex, that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The KG decarboxylase and KG dehydrogenase reactions provide two alternative, tightly regulated, pathways connecting the oxidative and reductive branches of the TCA cycle. Indicus|evm.model.PRDE01038812.1.1 P9WK35 RISA_MYCTU 62.500 0.991667 0.597015 ribE - Riboflavin synthase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ribE gene Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil. Indicus|evm.model.PRDE01038838.1.1 Q89YZ7 PEPT_BACTN 69.048 0.932584 0.218673 pepT - Peptidase T - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - pepT gene Cleaves the N-terminal amino acid of tripeptides. Indicus|evm.model.PRDE01038853.1.1 O21241 NDUS1_RECAM 63.095 0.710526 0.164978 NAD11 - NADH-ubiquinone oxidoreductase 75 kDa subunit - Reclinomonas americana - NAD11 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By similarity). Indicus|evm.model.PRDE01038989.1.1 P0ADM3 YIDH_SHIFL 51.887 0.913043 1 yidH - Inner membrane protein YidH - Shigella flexneri - yidH gene Indicus|evm.model.PRDE01039217.1.1 Q58722 Y1326_METJA 52.632 0.984962 0.340153 MJ1326 - Uncharacterized GTP-binding protein MJ1326 - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) - MJ1326 gene cytoplasm, GTP binding, cytoplasmic translation Indicus|evm.model.PRDE01039221.1.1 Q5YZT7 SYG_NOCFA 76.744 0.977099 0.281116 glyQS - Glycine--tRNA ligase - Nocardia farcinica (strain IFM 10152) - glyQS gene Catalyzes the attachment of glycine to tRNA(Gly). Indicus|evm.model.PRDE01039284.1.1 Q0S868 KSTR_RHOJR 66.935 0.991935 0.584906 kstR - HTH-type transcriptional repressor KstR - Rhodococcus jostii (strain RHA1) - kstR gene Controls the expression of genes used for utilizing diverse lipids as energy sources. Indicus|evm.model.PRDE01039321.1.1 P31678 OTSB_ECOLI 52.083 0.766129 0.466165 otsB - Trehalose-6-phosphate phosphatase - Escherichia coli (strain K12) - otsB gene Removes the phosphate from trehalose 6-phosphate (Tre6P) to produce free trehalose. Also catalyzes the dephosphorylation of glucose-6-phosphate (Glu6P) and 2-deoxyglucose-6-phosphate (2dGlu6P). Indicus|evm.model.PRDE01039365.1.1 A8M5I9 FBID_SALAI 48.168 0.682482 1.28037 fbiD - Phosphoenolpyruvate guanylyltransferase - Salinispora arenicola (strain CNS-205) - fbiD gene Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Indicus|evm.model.PRDE01039381.1.1 Q8NRC3 ODO12_CORGL 48.000 0.972028 0.117117 odhA - 2-oxoglutarate dehydrogenase E1/E2 component - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - odhA gene Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF. Indicus|evm.model.PRDE01039421.1.1 P95539 CATE_PSEPU 59.063 0.87218 0.748242 katE - Catalase HPII - Pseudomonas putida - katE gene Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Indicus|evm.model.PRDE01039429.1.1 P9WNA6 ECCC4_MYCTO 51.667 0.868613 0.110841 eccC4 - ESX-4 secretion system protein EccC4 - Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) - eccC4 gene Indicus|evm.model.PRDE01039450.1.1 Q2G8L3 PSD_NOVAD 83.562 0.972973 0.293651 psd - Phosphatidylserine decarboxylase proenzyme - Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199) - psd gene Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Indicus|evm.model.PRDE01039685.1.1 Q9KDI4 YAJC_BACHD 45.455 0.91358 0.920455 yajC - Sec translocon accessory complex subunit YajC - Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) - yajC gene The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. Indicus|evm.model.PRDE01039700.1.1 A2VDC2 HIBCH_XENLA 46.154 0.889655 0.376623 hibch - 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor - Xenopus laevis (African clawed frog) - hibch gene Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). Indicus|evm.model.PRDE01039709.1.1 P33363 BGLX_ECOLI 89.634 0.993902 0.214379 bglX - Periplasmic beta-glucosidase precursor - Escherichia coli (strain K12) - bglX gene outer membrane-bounded periplasmic space, periplasmic space, beta-glucosidase activity, glucosidase activity, glucan catabolic process Indicus|evm.model.PRDE01039773.1.1 P39583 YWAC_BACSU 46.721 0.691429 0.833333 ywaC - GTP pyrophosphokinase YwaC - Bacillus subtilis (strain 168) - ywaC gene Functions as a (p)ppGpp synthase; GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis (PubMed:18067544). Overexpression in relA mutants (triple relA-yjbM-ywaC deletions and single relA deletions) leads to growth arrest; GTP levels fall drastically, various guanine-related nucleotides are synthesized (ppGp or pGpp), the cellular transcriptional profile changes dramatically and 70S ribosome dimerization occurs (PubMed:22950019). Overexpression in the presence of a wild-type relA gene does not have these effects (PubMed:22950019). In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. activities in response to changes in nutritional abundance. YwaC has probably a minor role in stringent response (PubMed:18067544). Indicus|evm.model.PRDE01039778.1.1 P44801 DHAS_HAEIN 65.441 0.931034 0.390836 asd - Aspartate-semialdehyde dehydrogenase - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - asd gene Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate. Indicus|evm.model.PRDE01039863.1.1 P80094 FADH_AMYME 71.053 0.961538 0.216667 S-(hydroxymethyl)mycothiol dehydrogenase - Amycolatopsis methanolica Indicus|evm.model.PRDE01039868.1.1 O86820 END8B_STRCO 48.205 0.994845 0.702899 nei - Probable endonuclease 8 2 - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - nei gene Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Indicus|evm.model.PRDE01040021.1.1 B2GFL1 DDL_KOCRD 69.620 0.939759 0.21671 ddl - D-alanine--D-alanine ligase - Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201) - ddl gene Cell wall formation. Indicus|evm.model.PRDE01040044.1.1 Q5EA79 GALM_BOVIN 46.897 0.993103 0.423977 GALM - Galactose mutarotase - Bos taurus (Bovine) - GALM gene Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose. Indicus|evm.model.PRDE01040073.1.1 O86564 SDHL_STRCO 56.790 0.958333 0.369231 sdaA - L-serine dehydratase - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - sdaA gene L-serine ammonia-lyase activity Indicus|evm.model.PRDE01040374.1.1 Q9I2A0 LIUE_PSEAE 43.478 0.966102 0.393333 liuE - 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - liuE gene Involved in the L-leucine, isovalerate and acyclic monoterpene catabolism. Catalyzes the cleavage of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to yield acetyl-CoA and acetoacetate. It can also catalyze the cleavage of 3-hydroxy-3-isohexenylglutaryl-CoA (HIHG_CoA) to yield 7-methyl-3-oxooct-6-enoyl-CoA and acetate. Indicus|evm.model.PRDE01040500.1.1 Q5YYG7 CAPP_NOCFA 67.769 0.875912 0.148429 ppc - Phosphoenolpyruvate carboxylase - Nocardia farcinica (strain IFM 10152) - ppc gene Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Indicus|evm.model.PRDE01040858.1.1 Q9XBM7 PTM3C_KLEPN 98.830 0.994152 0.269291 mtlA - PTS system mannitol-specific EIICBA component - Klebsiella pneumoniae - mtlA gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in D-mannitol transport. Indicus|evm.model.PRDE01040894.1.1 A9WS85 SYL_RENSM 72.294 0.950413 0.280742 leuS - Leucine--tRNA ligase - Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) - leuS gene Indicus|evm.model.PRDE01040939.1.2 Q9P3X9 PPID_NEUCR 68.047 0.961783 0.418667 cyp41 - 41 kDa peptidyl-prolyl cis-trans isomerase - Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) - cyp41 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Indicus|evm.model.PRDE01040957.1.1 Q14153 FA53B_HUMAN 60.833 0.980392 0.241706 FAM53B - Protein FAM53B - Homo sapiens (Human) - FAM53B gene Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. Indicus|evm.model.PRDE01041004.1.1 Q026Q2 LON_SOLUE 76.119 0.992537 0.166253 lon - Lon protease - Solibacter usitatus (strain Ellin6076) - lon gene ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Indicus|evm.model.PRDE01041022.1.1 B2RXF5 ZBT42_HUMAN 94.545 0.990909 0.260664 ZBTB42 - Zinc finger and BTB domain-containing protein 42 - Homo sapiens (Human) - ZBTB42 gene Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Indicus|evm.model.PRDE01041081.1.1 B1L765 GYAR_KORCO 46.809 0.893204 0.620482 gyaR - Glyoxylate reductase - Korarchaeum cryptofilum (strain OPF8) - gyaR gene cytosol, glyoxylate reductase (NADP+) activity, hydroxypyruvate reductase activity Indicus|evm.model.PRDE01041089.1.1 Q88RC0 DAVD_PSEPK 68.715 0.983425 0.377083 davD - Glutarate-semialdehyde dehydrogenase - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - davD gene Catalyzes the conversion of 5-oxopentanoate (glutarate semialdehyde) to glutarate. Involved in L-lysine degradation. Indicus|evm.model.PRDE01041109.1.1 B0V876 THIG_ACIBY 98.214 0.982301 0.43295 thiG - Thiazole synthase - Acinetobacter baumannii (strain AYE) - thiG gene Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. Indicus|evm.model.PRDE01041137.1.1 P25477 CAPSD_BPP2 57.895 0.978495 0.260504 N - Capsid proteins precursor - Escherichia phage P2 - N gene P2 proheads and capsids consist primarily of N*, a 36.7 kDa protein and two minor components, H1 (39 kDa) and H2 (38.6 kDa). Indicus|evm.model.PRDE01041137.1.2 P25476 VPM_BPP2 52.294 0.955357 0.453441 M - Terminase, endonuclease subunit - Escherichia phage P2 - M gene M protein is probably an endonuclease which directs cos cleavage. The Q, P and M proteins are needed to package DNA into proheads and for the conversion of proheads to capsids. Indicus|evm.model.PRDE01041151.1.1 Q5YVL8 HMUV_NOCFA 55.224 0.653465 0.350694 hmuV - Hemin import ATP-binding protein HmuV - Nocardia farcinica (strain IFM 10152) - hmuV gene Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01041187.1.1 Q73VM3 SMC_MYCPA 83.750 0.9875 0.0668896 smc - Chromosome partition protein Smc - Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) - smc gene Required for chromosome condensation and partitioning. Indicus|evm.model.PRDE01041404.1.1 Q7X2N3 SYV_SPHEL 90.476 0.993197 0.181258 valS - Valine--tRNA ligase - Sphingomonas elodea - valS gene Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner. Indicus|evm.model.PRDE01041458.1.1 P77455 PAAZ_ECOLI 58.015 0.962963 0.198238 paaZ - Bifunctional protein PaaZ - Escherichia coli (strain K12) - paaZ gene Catalyzes the hydrolytic ring cleavage of 2-oxepin-2(3H)-ylideneacetyl-CoA (oxepin-CoA) via the open-chain aldehyde intermediate to yield 3-oxo-5,6-dehydrosuberyl-CoA. The enzyme consists of a C-terminal (R)-specific enoyl-CoA hydratase domain (formerly MaoC) that cleaves the ring and produces the highly reactive 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde and an N-terminal NADP-dependent aldehyde dehydrogenase domain that oxidizes the aldehyde to 3-oxo-5,6-dehydrosuberyl-CoA. Can also use crotonyl-CoA as substrate. Indicus|evm.model.PRDE01041531.1.1 B5EQ47 RECA_ACIF5 62.500 0.54023 0.252174 recA - Protein RecA - Acidithiobacillus ferrooxidans (strain ATCC 53993) - recA gene Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. Indicus|evm.model.PRDE01041556.1.1 B4JII0 SPAST_DROGR 52.174 0.801802 0.141944 spas - Spastin - Drosophila grimshawi (Hawaiian fruit fly) - spas gene ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Indicus|evm.model.PRDE01041578.1.1 Q9HBG4 VPP4_HUMAN 52.459 0.526087 0.27381 ATP6V0A4 - V-type proton ATPase 116 kDa subunit a isoform 4 - Homo sapiens (Human) - ATP6V0A4 gene Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. Indicus|evm.model.PRDE01041689.1.1 B8BKI8 MCM2_ORYSI 48.739 0.681287 0.355879 OsI_36121 - DNA replication licensing factor MCM2 - Oryza sativa subsp. indica (Rice) - OsI_36121 gene Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells. Indicus|evm.model.PRDE01041804.1.1 Q9CP90 YCHF_PASMU 56.522 0.681818 0.181818 ychF - Ribosome-binding ATPase YchF - Pasteurella multocida (strain Pm70) - ychF gene ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. Indicus|evm.model.PRDE01042153.1.1 P07823 BIP_MESAU 60.287 0.869382 1.08869 HSPA5 - Endoplasmic reticulum chaperone BiP precursor - Mesocricetus auratus (Golden hamster) - HSPA5 gene Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity). Indicus|evm.model.PRDE01042235.1.1 P42064 APPD_BACSU 48.062 0.962406 0.405488 appD - Oligopeptide transport ATP-binding protein AppD - Bacillus subtilis (strain 168) - appD gene This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transporting tripeptides. Probably responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01042307.1.1 P76081 PAAE_ECOLI 73.585 0.846774 0.348315 paaE - 1,2-phenylacetyl-CoA epoxidase, subunit E - Escherichia coli (strain K12) - paaE gene Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit E is a reductase with a preference for NADPH and FAD, capable of reducing cytochrome c. Indicus|evm.model.PRDE01042344.1.1 P09041 PGK2_MOUSE 59.848 0.98731 0.944844 Pgk2 - Phosphoglycerate kinase 2 - Mus musculus (Mouse) - Pgk2 gene Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis (PubMed:19759366). Indicus|evm.model.PRDE01042360.1.1 Q8FPI1 Y1797_COREF 51.724 0.483051 0.280285 CE1797 - Uncharacterized RNA methyltransferase CE1797 - Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) - CE1797 gene Indicus|evm.model.PRDE01042364.1.1 C1AW00 ATPG_RHOOB 62.349 0.993902 1.00613 atpG - ATP synthase gamma chain - Rhodococcus opacus (strain B4) - atpG gene Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. Indicus|evm.model.PRDE01042380.1.1 P52156 RHO_RHOS4 83.230 0.993789 0.381517 rho - Transcription termination factor Rho - Rhodobacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) - rho gene Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template. Indicus|evm.model.PRDE01042405.1.2 P0A0E4 MERA_STAES 52.055 0.973154 0.272395 merA - Mercuric reductase - Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) - merA gene Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) (By similarity). Indicus|evm.model.PRDE01042408.1.1 Q67N86 BIOF_SYMTH 65.068 0.953642 0.385204 STH1872 - 8-amino-7-oxononanoate synthase - Symbiobacterium thermophilum (strain T / IAM 14863) - STH1872 gene Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Indicus|evm.model.PRDE01042486.1.1 O94606 JMJ4_SCHPO 40.385 0.907975 0.344609 jmj4 - JmjC domain-containing protein 4 - Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) - jmj4 gene Has a role in meiosis. Indicus|evm.model.PRDE01042542.1.1 P77316 YBDR_ECOLI 74.013 0.993421 0.737864 ybdR - Uncharacterized zinc-type alcohol dehydrogenase-like protein YbdR - Escherichia coli (strain K12) - ybdR gene Indicus|evm.model.PRDE01042651.1.2 Q69ZQ2 ISY1_MOUSE 48.408 0.827027 0.649123 Isy1 - Pre-mRNA-splicing factor ISY1 homolog - Mus musculus (Mouse) - Isy1 gene Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation (PubMed:26255770, PubMed:29804889). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (PubMed:26255770). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (PubMed:29804889). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (PubMed:29804889). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes the transition to the primed state (PubMed:29804889). Involved in pre-mRNA splicing as component of the spliceosome. Indicus|evm.model.PRDE01042652.1.1 Q0S8V5 GCS23_RHOJR 54.610 0.952381 0.185372 RHA1_ro04240 - Putative glutamate--cysteine ligase 2-3 - Rhodococcus jostii (strain RHA1) - RHA1_ro04240 gene ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity. Indicus|evm.model.PRDE01042748.1.1 Q0RYC2 Y8670_RHOJR 67.196 0.973404 0.189707 RHA1_ro08670 - UPF0182 protein RHA1_ro08670 - Rhodococcus jostii (strain RHA1) - RHA1_ro08670 gene Indicus|evm.model.PRDE01042763.1.1 P48050 KCNJ4_HUMAN 93.671 0.993631 0.352809 KCNJ4 - Inward rectifier potassium channel 4 - Homo sapiens (Human) - KCNJ4 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). Indicus|evm.model.PRDE01042978.1.1 Q3BK72 FTSZL_MAGGM 78.788 0.748092 0.405573 ftsZ-like - FtsZ-like protein - Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1) - ftsZ-like gene Required for synthesis of single-domain magnetite particles and magnetosomes, especially in the absence of nitrate. Forms filaments, which form bundles in the presence of GTP. Has both GTPase and ATPase activity; GTPase is 2.5 time more efficient. Has no activity on CTP or TTP (PubMed:20023033). May be involved in redox control for magnetite crystallization (Probable). Mild overexpression causes cell elongation (PubMed:24272781). May recruit other proteins (MamX, MamY and MamZ and possibly Mms6) to a complex required for biomineralization (Probable). Indicus|evm.model.PRDE01043049.1.1 P0A615 Y2742_MYCBO 61.719 0.984556 0.652393 BQ2027_MB2742 - Uncharacterized membrane protein Mb2742 - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - BQ2027_MB2742 gene Indicus|evm.model.PRDE01043495.1.1 O88011 RIBA_STRCO 64.615 0.928058 0.628959 ribA - GTP cyclohydrolase-2 - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - ribA gene Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. Indicus|evm.model.PRDE01043862.1.1 Q93CB7 MTRB_MYCPA 65.957 0.756098 0.217699 mtrB - Sensor histidine kinase MtrB - Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) - mtrB gene Member of the two-component regulatory system MtrA/MtrB. Seems to function as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals (By similarity). Indicus|evm.model.PRDE01043995.1.1 Q2SZ20 KATG_BURTA 80.822 0.972973 0.101648 katG - Catalase-peroxidase - Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264) - katG gene Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Indicus|evm.model.PRDE01044127.1.1 P29925 NQO13_PARDE 72.816 0.990291 0.20078 nqo13 - NADH-quinone oxidoreductase chain 13 - Paracoccus denitrificans - nqo13 gene NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Indicus|evm.model.PRDE01044774.1.1 B0RB71 RS11_CLAMS 83.750 0.918605 0.651515 rpsK - 30S ribosomal protein S11 - Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) - rpsK gene Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. Indicus|evm.model.PRDE01044774.1.2 A6W5W3 RS13_KINRD 85.321 0.972973 0.880952 rpsM - 30S ribosomal protein S13 - Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) - rpsM gene Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Indicus|evm.model.PRDE01045511.1.1 A8AI31 OPGH_CITK8 94.631 0.993289 0.17696 mdoH - Glucans biosynthesis glucosyltransferase H - Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) - mdoH gene Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). Indicus|evm.model.PRDE01045581.1.1 P37478 WALR_BACSU 71.983 0.982906 0.995745 walR - Transcriptional regulatory protein WalR - Bacillus subtilis (strain 168) - walR gene Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Binds to the ftsAZ P1 promoter sequence in vitro. WalR has been shown to directly bind to the regulatory regions of yocH, ykvT, tagAB/tagDEF. Activates cwlO, lytE and ydjM and represses yoeB and yjeA. Indicus|evm.model.PRDE01045581.1.3 P77735 YAJO_ECOLI 49.013 0.939873 0.975309 yajO - 1-deoxyxylulose-5-phosphate synthase YajO - Escherichia coli (strain K12) - yajO gene Catalyzes the conversion of ribulose 5-phosphate (Ru5P) to 1-deoxy-D-xylulose 5-phosphate (DXP), providing a direct route from pentoses to terpenes. May play a role in biosynthesis of DXP under conditions of thiamine starvation. Indicus|evm.model.PRDE01045581.1.15 Q03D91 MSCL_PEDPA 77.143 0.978723 1.00714 mscL - Large-conductance mechanosensitive channel - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - mscL gene Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. Indicus|evm.model.PRDE01045581.1.17 Q9X4M1 ACKA1_LACSS 59.517 0.989362 0.954315 ackA1 - Acetate kinase 1 - Lactobacillus sakei subsp. sakei (strain 23K) - ackA1 gene Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Indicus|evm.model.PRDE01045581.1.22 Q03D71 ADDA_PEDPA 71.179 0.889507 1.01862 addA - ATP-dependent helicase/nuclease subunit A - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - addA gene The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities. Indicus|evm.model.PRDE01045581.1.23 Q03D70 ADDB_PEDPA 70.211 0.997243 0.912752 rexB - ATP-dependent helicase/deoxyribonuclease subunit B - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rexB gene The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity. Indicus|evm.model.PRDE01045581.1.25 A0A2A5JY22 NUCLP_PAELB 49.750 0.980344 0.937788 PL1_3014 - Nucleobase transporter PlUacP - Paenibacillus larvae subsp. larvae (strain NRRL B-3650 / LMG 16245) - PL1_3014 gene Uptake of the purines adenine and guanine, and the pyrimidine uracil. Transport is probably proton-dependent. Indicus|evm.model.PRDE01045581.1.26 Q7VG78 GUAA_HELHP 50.602 0.953757 0.125818 guaA - Probable GMP synthase [glutamine-hydrolyzing] - Helicobacter hepaticus (strain ATCC 51449 / 3B1) - guaA gene Catalyzes the synthesis of GMP from XMP. Indicus|evm.model.PRDE01045581.1.29 Q927Z0 CLS_LISIN 50.860 0.990244 0.850622 cls - Cardiolipin synthase - Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) - cls gene Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Indicus|evm.model.PRDE01045581.1.33 Q03D60 MNMG_PEDPA 93.071 0.996855 0.99843 mnmG - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - mnmG gene NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Indicus|evm.model.PRDE01045581.1.34 Q03D59 MNME_PEDPA 89.871 0.721184 1.38362 mnmE - tRNA modification GTPase MnmE - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - mnmE gene Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Indicus|evm.model.PRDE01045581.1.35 Q03I60 DNAA_PEDPA 90.845 0.995316 0.957399 dnaA - Chromosomal replication initiator protein DnaA - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - dnaA gene Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Indicus|evm.model.PRDE01045581.1.36 Q03I57 RECF_PEDPA 84.211 0.494429 1.91979 recF - DNA replication and repair protein RecF - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - recF gene The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. Indicus|evm.model.PRDE01045581.1.37 Q839Z1 GYRB_ENTFA 70.550 0.996748 0.957944 gyrB - DNA gyrase subunit B - Enterococcus faecalis (strain ATCC 700802 / V583) - gyrB gene DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Indicus|evm.model.PRDE01045581.1.38 Q8DPM2 GYRA_STRR6 67.113 0.969048 1.0219 gyrA - DNA gyrase subunit A - Streptococcus pneumoniae (strain ATCC BAA-255 / R6) - gyrA gene A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. Indicus|evm.model.PRDE01045581.1.39 Q03UD8 RS6_LACBA 84.270 0.389381 2.30612 rpsF - 30S ribosomal protein S6 - Lactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947) - rpsF gene Binds together with S18 to 16S ribosomal RNA. Indicus|evm.model.PRDE01045581.1.40 A0A0H3GCG4 PDEA_LISM4 50.163 0.9791 0.946728 pdeA - Cyclic-di-AMP phosphodiesterase PdeA - Listeria monocytogenes serotype 1/2a (strain 10403S) - pdeA gene Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP) (PubMed:23716572, PubMed:25965978). Overexpression decreases export of c-di-AMP, leads to slightly increased susceptibility to the antibiotic cefuroxime and somewhat slower growth in macrophages (PubMed:23716572). There are at least 2 PDEs for c-di-AMP in this bacteria (this one and pgpH); this may be the major PDE for intracellular growth in host macrophages (PubMed:25583510). During host infection c-di-AMP is secreted into the host cytoplasm which leads to interferon-beta production and secretion by the host (Probable). c-di-AMP is a second messenger that mediates growth, cell wall stability and virulence (Probable). May monitor cellular heme or NO levels (By similarity). Indicus|evm.model.PRDE01045581.1.41 Q03I50 RL9_PEDPA 83.019 0.972222 0.72 rplI - 50S ribosomal protein L9 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rplI gene Binds to the 23S rRNA. Indicus|evm.model.PRDE01045581.1.42 P37469 DNAC_BACSU 60.047 0.972158 0.949339 dnaC - Replicative DNA helicase - Bacillus subtilis (strain 168) - dnaC gene cytosol, DNA helicase activity, DNA unwinding involved in DNA replication Indicus|evm.model.PRDE01045581.1.44 Q5HLN4 HRTA_STAEQ 45.745 0.353728 2.35586 hrtA - Putative hemin import ATP-binding protein HrtA - Staphylococcus epidermidis (strain ATCC 35984 / RP62A) - hrtA gene Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). Indicus|evm.model.PRDE01045581.1.47 Q93T20 CHRR_PSEPU 51.639 0.944882 0.682796 chrR - Quinone reductase - Pseudomonas putida - chrR gene Catalyzes the reduction of quinones. Acts by simultaneous two-electron transfer, avoiding formation of highly reactive semiquinone intermediates and producing quinols that promote tolerance of H(2)O(2). Quinone reduction is probably the primary biological role of ChrR (By similarity). Can also reduce toxic chromate to insoluble and less toxic Cr(3+). Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen. This reaction produces transiently a minimal amount of the toxic Cr(5+) species and reactive oxygen species (ROS). Chromate reduction protects the cell against chromate toxicity, but is likely a secondary activity (By similarity) (PubMed:10788340). Indicus|evm.model.PRDE01045581.1.49 Q03DS0 OTC_PEDPA 92.971 0.993631 0.942943 arcB - Ornithine carbamoyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - arcB gene Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. Indicus|evm.model.PRDE01045581.1.50 Q6GHR6 ARCC1_STAAR 62.868 0.978261 0.890323 arcC1 - Carbamate kinase 1 - Staphylococcus aureus (strain MRSA252) - arcC1 gene Indicus|evm.model.PRDE01045581.1.51 B2GAF4 ARCA_LACF3 88.452 0.992665 1.00491 arcA - Arginine deiminase - Lactobacillus fermentum (strain NBRC 3956 / LMG 18251) - arcA gene Indicus|evm.model.PRDE01045581.1.52 O53092 ARCD_LACSK 47.439 0.991826 0.772632 arcD - Arginine/ornithine antiporter - Lactobacillus sakei - arcD gene Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway. Indicus|evm.model.PRDE01045581.1.57 P54176 HLY3_BACCE 47.205 0.893855 0.817352 Hemolysin-3 - Bacillus cereus Indicus|evm.model.PRDE01045742.1.1 Q8CFK2 TF3B_MOUSE 45.133 0.303279 0.54142 Brf1 - Transcription factor IIIB 90 kDa subunit - Mus musculus (Mouse) - Brf1 gene General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. Indicus|evm.model.PRDE01045777.1.1 B2FPM0 HIS8_STRMK 76.471 0.967213 0.335165 hisC - Histidinol-phosphate aminotransferase - Stenotrophomonas maltophilia (strain K279a) - hisC gene Indicus|evm.model.PRDE01046107.1.1 O86564 SDHL_STRCO 57.692 0.995708 0.512088 sdaA - L-serine dehydratase - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - sdaA gene L-serine ammonia-lyase activity Indicus|evm.model.PRDE01046647.1.1 P9WHF5 THT3_MYCTU 49.541 0.818182 0.464789 sseB - Putative thiosulfate sulfurtransferase SseB - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - sseB gene thiosulfate sulfurtransferase activity, transsulfuration Indicus|evm.model.PRDE01046679.1.1 P33101 RL15_MICLU 77.778 0.861446 1.10667 rplO - 50S ribosomal protein L15 - Micrococcus luteus - rplO gene Binds to the 23S rRNA. Indicus|evm.model.PRDE01047048.1.1 Q84BZ3 ANDAC_BURCE 96.460 0.982456 0.269504 andAc - Anthranilate 1,2-dioxygenase large subunit - Burkholderia cepacia - andAc gene Oxygenase component of anthranilate dioxygenase multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into anthranilate to form catechol. Can also act on benzoate and salicylate but not on 2-chlorobenzoate or o-toluate. Indicus|evm.model.PRDE01047105.1.1 Q0BS26 ILVC_GRABC 88.889 0.347222 0.424779 ilvC - Ketol-acid reductoisomerase (NADP(+)) - Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) - ilvC gene Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. Indicus|evm.model.PRDE01047370.1.1 A5WGE2 LPXA_PSYWF 67.188 0.969582 1.01544 lpxA - Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase - Psychrobacter sp. (strain PRwf-1) - lpxA gene Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Indicus|evm.model.PRDE01047437.1.1 Q0BXD3 THIE_HYPNA 63.415 0.555556 0.325792 thiE - Thiamine-phosphate synthase - Hyphomonas neptunium (strain ATCC 15444) - thiE gene Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Indicus|evm.model.PRDE01047819.1.1 Q9CDA8 EMBA_MYCLE 54.545 0.740741 0.145815 embA - Probable arabinosyltransferase A - Mycobacterium leprae (strain TN) - embA gene Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan. Indicus|evm.model.PRDE01047877.1.1 Q8NM11 PYRE_CORGL 78.488 0.919355 1.01087 pyrE - Orotate phosphoribosyltransferase - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - pyrE gene Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). Indicus|evm.model.PRDE01048217.1.1 Q73F99 EFG_BACC1 74.820 0.985714 0.202312 fusA - Elongation factor G - Bacillus cereus (strain ATCC 10987 / NRS 248) - fusA gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Indicus|evm.model.PRDE01048242.1.1 P37032 ACON_LEGPH 55.263 0.889764 0.142536 acn - Aconitate hydratase A - Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) - acn gene Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. The apo form of AcnA functions as a RNA-binding regulatory protein (PubMed:8366052). Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate (By similarity). Indicus|evm.model.PRDE01048250.1.1 Q32BS6 FTSP_SHIDS 84.706 0.988235 0.180851 ftsP - Cell division protein FtsP precursor - Shigella dysenteriae serotype 1 (strain Sd197) - ftsP gene Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress. Indicus|evm.model.PRDE01048266.1.1 P37902 GLTI_ECOLI 57.426 0.757576 0.437086 gltI - Glutamate/aspartate import solute-binding protein precursor - Escherichia coli (strain K12) - gltI gene Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate. Indicus|evm.model.PRDE01048342.1.1 Q8P8L7 CCME2_XANCP 76.596 0.939394 0.651316 ccmE2 - Cytochrome c-type biogenesis protein CcmE 2 - Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) - ccmE2 gene Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Indicus|evm.model.PRDE01048355.1.1 Q75JR2 IDHP_DICDI 61.097 0.979003 0.890187 idhM - Isocitrate dehydrogenase [NADP], mitochondrial precursor - Dictyostelium discoideum (Slime mold) - idhM gene mitochondrion, isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, 2-oxoglutarate metabolic process, isocitrate metabolic process, NADP metabolic process Indicus|evm.model.PRDE01048434.1.1 P64724 Y514_MYCBO 62.857 0.988636 0.49162 BQ2027_MB0514 - Uncharacterized protein Mb0514 - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - BQ2027_MB0514 gene Indicus|evm.model.PRDE01048478.1.1 P26264 CYSQ_SALTY 59.322 0.935484 0.504065 cysQ - 3'(2'),5'-bisphosphate nucleotidase CysQ - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - cysQ gene Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Indicus|evm.model.PRDE01048502.1.1 B0T1G7 PRMA_CAUSK 69.412 0.954545 0.305556 prmA - Ribosomal protein L11 methyltransferase - Caulobacter sp. (strain K31) - prmA gene Methylates ribosomal protein L11. Indicus|evm.model.PRDE01048526.1.1 P25152 BSAP_BACSU 56.410 0.205405 0.406593 ywaD - Aminopeptidase YwaD precursor - Bacillus subtilis (strain 168) - ywaD gene Catalyzes the hydrolysis of a range of N-terminal amino acids. Indicus|evm.model.PRDE01048581.1.1 P9WQB9 ADHD_MYCTU 47.368 0.824176 0.247283 adhD - Putative alcohol dehydrogenase D - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - adhD gene Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Indicus|evm.model.PRDE01048612.1.1 P0AGF9 TDCB_SHIFL 45.283 0.772059 0.413374 tdcB - L-threonine dehydratase catabolic TdcB - Shigella flexneri - tdcB gene Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine to yield pyruvate via analogous enamine/imine intermediates (By similarity). Indicus|evm.model.PRDE01048661.1.1 P74068 Y1263_SYNY3 48.322 0.961039 0.496774 sll1263 - Uncharacterized transporter sll1263 - Synechocystis sp. (strain PCC 6803 / Kazusa) - sll1263 gene membrane, plasma membrane, cadmium ion transmembrane transporter activity, cation transmembrane transporter activity, ferrous iron transmembrane transporter activity, zinc efflux active transmembrane transporter activity, cellular cadmium ion homeostasis, cellular iron ion homeostasis, cellular zinc ion homeostasis Indicus|evm.model.PRDE01048940.1.1 P23101 XYLZ_PSEPU 50.926 0.996904 0.96131 xylZ - Toluate 1,2-dioxygenase electron transfer component - Pseudomonas putida - xylZ gene Electron transfer component of toluate 1,2-dioxygenase system. Indicus|evm.model.PRDE01049012.1.1 Q7LYX6 MALG_THELN 50.000 0.967742 0.334532 malG - Trehalose/maltose transport system permease protein MalG - Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) - malG gene Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import. Responsible for the translocation of the substrate across the membrane. Indicus|evm.model.PRDE01049097.1.1 O53182 KORA_MYCTU 70.000 0.993333 0.229709 korA - 2-oxoglutarate oxidoreductase subunit KorA - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - korA gene Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha-ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitro; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M.tuberculosis during infection, flux through KOR likely represents an important step in intermediary metabolism in vivo. KOR-dependent decarboxylation of KG also appears to be an important source of CO(2) in M.tuberculosis metabolism. Indicus|evm.model.PRDE01049207.1.1 Q46845 YGHU_ECOLI 62.857 0.962963 0.375 yghU - Disulfide-bond oxidoreductase YghU - Escherichia coli (strain K12) - yghU gene Exhibits a robust glutathione (GSH)-dependent disulfide-bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides, such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide, but does not reduce H(2)O(2) or tert-butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate. Indicus|evm.model.PRDE01049276.1.1 Q6AER9 NADE_LEIXX 64.341 0.992248 0.462366 nadE - NH(3)-dependent NAD(+) synthetase - Leifsonia xyli subsp. xyli (strain CTCB07) - nadE gene Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. Indicus|evm.model.PRDE01049356.1.1 A3QGM4 XNI_SHELP 45.963 0.987654 0.632812 xni - Flap endonuclease Xni - Shewanella loihica (strain ATCC BAA-1088 / PV-4) - xni gene Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Indicus|evm.model.PRDE01049404.1.1 Q9GLL1 CP4F_SHEEP 75.000 0.964706 0.160985 CYP4F21 - Prostaglandin E2 omega-hydroxylase CYP4F21 precursor - Ovis aries (Sheep) - CYP4F21 gene A cytochrome P450 monooxygenase that catalyzes the omega-hydroxylation of prostaglandin E2. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Indicus|evm.model.PRDE01049585.1.1 P44870 FTSY_HAEIN 49.038 0.682119 0.364734 ftsY - Signal recognition particle receptor FtsY - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - ftsY gene Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. Indicus|evm.model.PRDE01049693.1.1 A1TD77 SYR_MYCVP 82.558 0.994186 0.312727 argS - Arginine--tRNA ligase - Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1) - argS gene Indicus|evm.model.PRDE01049745.1.1 B0V4V6 DER_ACIBY 94.340 0.918605 0.366738 der - GTPase Der - Acinetobacter baumannii (strain AYE) - der gene GTPase that plays an essential role in the late steps of ribosome biogenesis. Indicus|evm.model.PRDE01049850.1.1 Q92IZ6 GYRA_RICCN 74.194 0.994624 0.205525 gyrA - DNA gyrase subunit A - Rickettsia conorii (strain ATCC VR-613 / Malish 7) - gyrA gene A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. Indicus|evm.model.PRDE01049856.1.1 Q7TTP0 HMP_BORPE 49.167 0.967213 0.303483 hmp - Flavohemoprotein - Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) - hmp gene Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Indicus|evm.model.PRDE01049879.1.1 Q9KR66 SIAM_VIBCH 46.341 0.953125 0.299766 siaM - Sialic acid TRAP transporter large permease protein SiaM - Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) - siaM gene Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPQM that catalyzes unidirectional Na(+)-dependent sialic acid uptake. Indicus|evm.model.PRDE01050399.1.1 Q8EZQ1 GLMS_LEPIN 56.604 0.972222 0.177049 glmS - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] - Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) - glmS gene Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Indicus|evm.model.PRDE01050539.1.1 Q32L83 BRI3_BOVIN 100.000 0.8 0.806452 BRI3 - Brain protein I3 - Bos taurus (Bovine) - BRI3 gene Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver. Indicus|evm.model.PRDE01050551.1.1 P10978 POLX_TOBAC 49.425 0.966292 0.0670181 Retrovirus-related Pol polyprotein from transposon TNT 1-94 - Nicotiana tabacum (Common tobacco) Indicus|evm.model.PRDE01050584.1.1 O08336 CYPB_BACSU 52.893 0.991736 0.114801 cypB - Bifunctional cytochrome P450/NADPH--P450 reductase 2 - Bacillus subtilis (strain 168) - cypB gene Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of a range of medium to long-chain fatty acids, with a preference for long-chain unsaturated and branched-chain fatty acids over saturated fatty acids. Hydroxylation of myristic acid occurs mainly at the omega-2 and omega-3 positions, in approximately equal proportions. Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain. Indicus|evm.model.PRDE01050669.1.1 A0LCK8 SECF_MAGMM 46.154 0.954887 0.427653 secF - Protein translocase subunit SecF - Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) - secF gene Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. Indicus|evm.model.PRDE01050690.1.1 P0CH00 RIR1B_MYCS2 52.229 0.987097 0.214681 nrdE2 - Ribonucleoside-diphosphate reductase subunit alpha 2 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - nrdE2 gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Indicus|evm.model.PRDE01050729.1.1 P51585 ALGD_AZOVI 48.936 0.707692 0.149083 algD - GDP-mannose 6-dehydrogenase - Azotobacter vinelandii - algD gene Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and is essential for cyst formation. Indicus|evm.model.PRDE01050836.1.1 Q8NQC8 ACR3_CORGL 66.897 0.993103 0.391892 acr3 - Arsenical-resistance protein Acr3 - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - acr3 gene Catalyzes the proton motive force-dependent arsenite efflux from the cell. Probably functions as an arsenite/H(+) antiporter. Does not transport antimonite. Indicus|evm.model.PRDE01051014.1.1 A6TCI1 RNC_KLEP7 98.413 0.992063 0.557522 rnc - Ribonuclease 3 - Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) - rnc gene Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. Indicus|evm.model.PRDE01051029.1.1 A8MYZ6 FOXO6_HUMAN 97.101 0.925676 0.300813 FOXO6 - Forkhead box protein O6 - Homo sapiens (Human) - FOXO6 gene Transcriptional activator. Indicus|evm.model.PRDE01051380.1.1 Q6QN14 U17L6_HUMAN 98.980 0.989796 0.246231 USP17L6P - Ubiquitin carboxyl-terminal hydrolase 17-like protein 6 - Homo sapiens (Human) - USP17L6P gene Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, cell migration, and the cellular response to viral infection. Seems to be non-functional in the regulation of apoptosis. Indicus|evm.model.PRDE01051395.1.1 P0ACC0 HEMY_SHIFL 86.154 0.984733 0.329146 hemY - Protein HemY - Shigella flexneri - hemY gene Involved in a late step of protoheme IX synthesis. Indicus|evm.model.PRDE01051441.1.1 P00579 RPOD_ECOLI 65.497 0.994152 0.278956 rpoD - RNA polymerase sigma factor RpoD - Escherichia coli (strain K12) - rpoD gene Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Preferentially transcribes genes associated with fast growth, such as ribosomal operons, other protein-synthesis related genes, rRNA- and tRNA-encoding genes and prfB. Indicus|evm.model.PRDE01051530.1.1 P43415 RL15_STRSC 82.456 0.982456 0.59375 rplO - 50S ribosomal protein L15 - Streptomyces scabiei - rplO gene Binds to the 23S rRNA. Indicus|evm.model.PRDE01051530.1.2 C0ZW44 RL30_RHOE4 78.000 0.924528 0.898305 rpmD - 50S ribosomal protein L30 - Rhodococcus erythropolis (strain PR4 / NBRC 100887) - rpmD gene Indicus|evm.model.PRDE01051561.1.1 Q8RQN5 PFKA_COREF 67.925 0.990566 0.306358 pfkA - ATP-dependent 6-phosphofructokinase - Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) - pfkA gene Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Indicus|evm.model.PRDE01051562.1.1 Q9PA81 NUSG_XYLFA 67.416 0.916667 0.518919 nusG - Transcription termination/antitermination protein NusG - Xylella fastidiosa (strain 9a5c) - nusG gene Participates in transcription elongation, termination and antitermination. Indicus|evm.model.PRDE01051599.1.1 Q56952 YFEA_YERPE 83.929 0.295699 0.598071 yfeA - Periplasmic chelated iron-binding protein YfeA precursor - Yersinia pestis - yfeA gene Part of an ATP-driven transport system YfeABCD for chelated iron. Indicus|evm.model.PRDE01051634.1.1 Q59749 PARC_RHIME 52.703 0.972603 0.0963061 parC - DNA topoisomerase 4 subunit A - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - parC gene Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Indicus|evm.model.PRDE01051682.1.1 Q52978 PHAAB_RHIME 45.509 0.993902 0.164164 phaAB - Probable K(+)/H(+) antiporter subunit A/B - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - phaAB gene Part of a K(+) efflux system which is required for the adaptation of R.meliloti to alkaline pH as well as for the infection process during symbiotic nodule development. Indicus|evm.model.PRDE01051695.1.1 B0C9Y4 GLSA_ACAM1 55.340 0.990291 0.320872 glsA - Glutaminase - Acaryochloris marina (strain MBIC 11017) - glsA gene Indicus|evm.model.PRDE01051746.1.1 P9WJ03 SIR_MYCTU 60.984 0.987013 0.554955 sir - Sulfite reductase [ferredoxin] - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - sir gene Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors. Indicus|evm.model.PRDE01051793.1.1 Q4JV09 RL19_CORJK 81.818 0.323232 0.876106 rplS - 50S ribosomal protein L19 - Corynebacterium jeikeium (strain K411) - rplS gene This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. Indicus|evm.model.PRDE01051836.1.1 Q5YRX6 SYE_NOCFA 83.735 0.959302 0.351738 gltX - Glutamate--tRNA ligase - Nocardia farcinica (strain IFM 10152) - gltX gene Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). Indicus|evm.model.PRDE01051844.1.1 B2I1H8 GLMM_ACIBC 84.021 0.974747 0.444944 glmM - Phosphoglucosamine mutase - Acinetobacter baumannii (strain ACICU) - glmM gene Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. Indicus|evm.model.PRDE01051893.1.1 P0A5J3 MAP1_MYCBO 54.098 0.923077 0.22807 map - Methionine aminopeptidase - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - map gene Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. Indicus|evm.model.PRDE01051905.1.1 B0V6V5 RL14_ACIBY 100.000 0.982906 0.959016 rplN - 50S ribosomal protein L14 - Acinetobacter baumannii (strain AYE) - rplN gene Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome. Indicus|evm.model.PRDE01051919.1.1 Q5ZHT1 ACD11_CHICK 49.673 0.973684 0.195624 ACAD11 - Acyl-CoA dehydrogenase family member 11 - Gallus gallus (Chicken) - ACAD11 gene Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain. Indicus|evm.model.PRDE01051991.1.1 O06543 AMACR_MYCTU 54.088 0.993671 0.438889 mcr - Alpha-methylacyl-CoA racemase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - mcr gene Catalyzes the epimerization of (2R)- and (2S)-methylacyl-coenzyme A (CoA) thioesters (PubMed:15632186, PubMed:19854148, PubMed:26348625). Accepts as substrates a wide range of alpha-methylacyl-CoAs, including (2R)-2-methylmyristoyl-CoA and (2S)-2-methylmyristoyl-CoA, (2R)-pristanoyl-CoA and (2S)-pristanoyl-CoA, and the cholesterol esters (25R)-3-oxo-cholest-4-en-26-oyl-CoA and (25S)-3-oxo-cholest-4-en-26-oyl-CoA (PubMed:15632186, PubMed:26348625). Can also catalyze the interconversion of the non-physiologic substrates (2R)-ibuprofenoyl-CoA and (2S)-ibuprofenoyl-CoA, which are potential competitive inhibitors of the enzyme (PubMed:19854148). Indicus|evm.model.PRDE01052014.1.1 Q6ZRC1 CD050_HUMAN 73.846 0.927536 0.25 C4orf50 - Uncharacterized protein C4orf50 - Homo sapiens (Human) - C4orf50 gene Indicus|evm.model.PRDE01052100.1.1 Q8FB02 UVRA_ECOL6 65.476 0.966216 0.157447 uvrA - UvrABC system protein A - Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) - uvrA gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Indicus|evm.model.PRDE01052231.1.1 Q6F7T7 RPOA_ACIAD 97.949 0.989796 0.585075 rpoA - DNA-directed RNA polymerase subunit alpha - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - rpoA gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01052369.1.1 Q8NNK8 PIMB_CORGL 49.485 0.90566 0.278215 pimB - GDP-mannose-dependent monoacylated alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - pimB gene Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM) (PubMed:18421567, PubMed:18178556, PubMed:19395496). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 6 of a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1) to generate phosphatidyl-myo-inositol bearing alpha-1,2- and alpha-1,6-linked mannose residues (Ac1PIM2) (PubMed:18178556, PubMed:19395496). PimB also catalyzes the addition of a mannosyl residue from GDP-Man to the position 6 of phosphatidyl-myo-inositol bearing an acylated alpha-1,2-linked mannose residue (Ac1PIM1) to generate monoacylated phosphatidyl-myo-inositol bearing alpha-1,2- and alpha-1,6-linked mannose residues (Ac1PIM2) (By similarity). The addition of the second mannosyl residue by PimB preferentially occurs before the acylation of the mannosyl residue transferred by PimA (By similarity). Also able to transfer a mannosyl residue from GDP-Man to the position 6 of a phosphatidyl-myo-inositol (PI), but this reaction is very slow (By similarity). Indicus|evm.model.PRDE01052369.1.2 P67474 Y2213_MYCBO 52.830 0.962264 0.137662 BQ2027_MB2213C - Probable endopeptidase Mb2213c - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - BQ2027_MB2213C gene Indicus|evm.model.PRDE01052387.1.1 D4ANV2 PLB1_ARTBC 45.098 0.413223 0.18818 ARB_05919 - Lysophospholipase ARB_05919 precursor - Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) - ARB_05919 gene Catalyzes the release of fatty acids from lysophospholipids (By similarity). Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging host cell membranes (By similarity). Indicus|evm.model.PRDE01052414.1.1 E3UUE6 FAC19_RHORH 50.000 0.968627 0.459459 fadD19 - 3-oxocholest-4-en-26-oate--CoA ligase - Rhodococcus rhodochrous - fadD19 gene Involved in the degradation of the side chains of C-24 branched-chain sterols. Catalyzes the ATP-dependent CoA thioesterification of the sterol 3-oxocholest-4-en-26-oate to yield 3-oxocholest-4-en-26-oyl-CoA. It can also use beta-sitosterol, campesterol and 3beta-hydroxy-5-cholesten-26-oate. Indicus|evm.model.PRDE01052494.1.1 Q9ZPX1 ARF5_ARATH 57.627 0.991525 0.637838 ARL2 - ADP-ribosylation factor-like protein 2 - Arabidopsis thaliana (Mouse-ear cress) - ARL2 gene Has a role in the cofactor-dependent pathway of microtubule biogenesis. Not essential for cell viability. May play a regulatory role in sequestring TFCD. Indicus|evm.model.PRDE01052520.1.1 A0R3C4 MAZG_MYCS2 54.545 0.915254 0.182099 mazG - Nucleoside triphosphate pyrophosphohydrolase - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - mazG gene Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation-induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP). Also involved in the transcriptional activation of RelA in response to oxidative stress. Indicus|evm.model.PRDE01052526.1.1 Q48815 HELA_LEGPN 68.293 0.254777 0.14924 helA - Protein HelA - Legionella pneumophila - helA gene Presumed to function with HelC and HelB in efflux of an unidentified substrate. Indicus|evm.model.PRDE01052595.1.1 A5GIG6 CINAL_SYNPW 53.947 0.555556 0.31106 SynWH7803_0305 - CinA-like protein - Synechococcus sp. (strain WH7803) - SynWH7803_0305 gene Indicus|evm.model.PRDE01052623.1.1 Q6MEP6 MURA_PARUW 53.125 0.979381 0.208602 murA - UDP-N-acetylglucosamine 1-carboxyvinyltransferase - Protochlamydia amoebophila (strain UWE25) - murA gene Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Indicus|evm.model.PRDE01052652.1.1 Q9LD95 SIGF_ARATH 48.936 0.96875 0.175503 SIGF - RNA polymerase sigma factor sigF, chloroplastic precursor - Arabidopsis thaliana (Mouse-ear cress) - SIGF gene Sigma factors are initiation factors that promote the attachment of plastid-encoded RNA polymerase (PEP) to specific initiation sites and are then released. Regulates transcription in chloroplast in a DG1-dependent manner. Involved in light-dependent chloroplast development. Required during early plant development and primary leaf formation. Indicus|evm.model.PRDE01052901.1.1 G3XD46 FTSI_PSEAE 50.000 0.895028 0.312608 ftsI - Peptidoglycan D,D-transpeptidase FtsI - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - ftsI gene Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin (PubMed:20580675). Indicus|evm.model.PRDE01053239.1.1 Q8FP96 Y1889_COREF 51.613 0.993377 0.616327 CE1889 - UPF0246 protein CE1889 - Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) - CE1889 gene Indicus|evm.model.PRDE01053300.1.1 Q53139 COBK_RHOER 61.290 0.344828 0.701613 cobK - Precorrin-6A reductase - Rhodococcus erythropolis - cobK gene Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. Indicus|evm.model.PRDE01053326.1.1 P0A4I8 CUTS_STRLI 45.570 0.503268 0.369565 cutS - Sensor protein CutS - Streptomyces lividans - cutS gene Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. Indicus|evm.model.PRDE01053334.1.1 Q219P7 RBL_RHOPB 89.764 0.992126 0.261856 cbbL - Ribulose bisphosphate carboxylase large chain - Rhodopseudomonas palustris (strain BisB18) - cbbL gene RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. Indicus|evm.model.PRDE01053623.1.1 A3M8W9 DNAK_ACIBT 96.341 0.947674 0.266254 dnaK - Chaperone protein DnaK - Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) - dnaK gene Acts as a chaperone. Indicus|evm.model.PRDE01053649.1.1 P04968 ILVA_ECOLI 55.932 0.982906 0.227626 ilvA - L-threonine dehydratase biosynthetic IlvA - Escherichia coli (strain K12) - ilvA gene Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. Indicus|evm.model.PRDE01053737.1.1 Q6AFZ0 SYI_LEIXX 67.593 0.990783 0.193923 ileS - Isoleucine--tRNA ligase - Leifsonia xyli subsp. xyli (strain CTCB07) - ileS gene Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Indicus|evm.model.PRDE01053859.1.1 P39920 FTSK_COXBU 61.682 0.890756 0.152956 ftsK - DNA translocase FtsK - Coxiella burnetii (strain RSA 493 / Nine Mile phase I) - ftsK gene Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity). Indicus|evm.model.PRDE01053945.1.1 B8H414 EFG_CAUVN 92.903 0.993548 0.223988 fusA - Elongation factor G - Caulobacter vibrioides (strain NA1000 / CB15N) - fusA gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Indicus|evm.model.PRDE01054083.1.1 Q89WY0 IPYR_BRADU 74.483 0.986301 0.820225 ppa - Inorganic pyrophosphatase - Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) - ppa gene Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Indicus|evm.model.PRDE01054170.1.1 Q46087 TRAT_AMIAI 72.549 0.980392 0.100394 nmoT - Transposase - Aminobacter aminovorans - nmoT gene Required for the transposition of the insertion element. Indicus|evm.model.PRDE01054204.1.1 Q6QUY7 ECTD_STRAQ 54.955 0.982143 0.377104 ectD - Ectoine dioxygenase - Streptomyces anulatus - ectD gene Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine. Indicus|evm.model.PRDE01054212.1.1 Q8PCE5 APAH_XANCP 81.250 0.995536 0.691358 apaH - Bis(5'-nucleosyl)-tetraphosphatase, symmetrical - Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) - apaH gene Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP. Indicus|evm.model.PRDE01054235.1.1 P96890 ACCA3_MYCTU 66.000 0.942857 0.175 accA3 - Biotin-dependent acyl-coenzyme A carboxylase alpha3 subunit - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - accA3 gene Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, resulting in the formation of carboxyl biotin (PubMed:16354663, PubMed:16385038, PubMed:17114269). When associated with the beta5 subunit AccD5, is involved in the carboxylation of acetyl-CoA and propionyl-CoA, with a preference for propionyl-CoA (PubMed:16354663, PubMed:16385038). When associated with the beta6 subunit AccD6, is involved in the carboxylation of acetyl-CoA and propionyl-CoA, with a preference for acetyl-CoA (PubMed:17114269). When associated with the beta4 subunit AccD4, the beta5 subunit AccD5 and the epsilon subunit AccE5, forms the LCC complex, which is involved in the carboxylation of long chain acyl-CoA (PubMed:16354663, PubMed:28222482). The LCC complex can use C16-C24 substrates, the highest specific activity is obtained with carboxy-C20-CoA (PubMed:28222482). Indicus|evm.model.PRDE01054294.1.1 Q6SSJ6 MOBA_COMTE 50.000 0.92053 0.236307 mobA - 3-hydroxybenzoate 4-monooxygenase - Comamonas testosteroni - mobA gene Converts 3-hydroxybenzoate (m-hydroxybenzoate), and to a lesser extent p-hydroxybenzoate, to 3,4-dihydroxybenzoate (protocatechuate). Also acts on a number of analogs of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions. Indicus|evm.model.PRDE01054306.1.2 P0AE45 YTFL_ECOLI 61.111 0.871951 0.36689 ytfL - UPF0053 inner membrane protein YtfL - Escherichia coli (strain K12) - ytfL gene plasma membrane Indicus|evm.model.PRDE01054478.1.1 Q01411 MANB_SALMO 49.275 0.603604 0.243421 manB - Phosphomannomutase - Salmonella montevideo - manB gene Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen. Indicus|evm.model.PRDE01054504.1.1 Q5Z1K7 TRUA_NOCFA 65.079 0.954315 0.766537 truA - tRNA pseudouridine synthase A - Nocardia farcinica (strain IFM 10152) - truA gene Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. Indicus|evm.model.PRDE01054537.1.1 A9I602 PUR5_BORPD 79.618 0.974843 0.455587 purM - Phosphoribosylformylglycinamidine cyclo-ligase - Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) - purM gene Indicus|evm.model.PRDE01054609.1.1 P11653 MUTB_PROFR 73.797 0.968831 0.528846 mutB - Methylmalonyl-CoA mutase large subunit - Propionibacterium freudenreichii subsp. shermanii - mutB gene Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. Indicus|evm.model.PRDE01054628.1.1 Q6NEC9 Y2346_CORDI 81.731 0.971698 0.21328 DIP2346 - UPF0371 protein DIP2346 - Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) - DIP2346 gene Indicus|evm.model.PRDE01054721.1.1 B8GWW6 ALKB_CAUVN 51.852 0.524752 0.918182 alkB - Alpha-ketoglutarate-dependent dioxygenase AlkB homolog - Caulobacter vibrioides (strain NA1000 / CB15N) - alkB gene Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents) (By similarity). Indicus|evm.model.PRDE01054731.1.1 O31826 YNGI_BACSU 58.678 0.952 0.227687 yngI - Putative acyl-CoA synthetase YngI - Bacillus subtilis (strain 168) - yngI gene medium-chain fatty acid-CoA ligase activity, fatty acid metabolic process Indicus|evm.model.PRDE01054810.1.1 P9WN57 GCH1_MYCTU 74.483 0.966443 0.737624 folE - GTP cyclohydrolase 1 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - folE gene cytoplasm, GTP binding, GTP cyclohydrolase I activity, zinc ion binding, tetrahydrobiopterin biosynthetic process Indicus|evm.model.PRDE01054810.1.2 P9WND1 DHPS1_MYCTU 67.188 0.984375 0.228571 folP1 - Dihydropteroate synthase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - folP1 gene Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Indicus|evm.model.PRDE01054837.1.1 Q9Z6S4 RIR2_CHLPN 71.774 0.960938 0.369942 nrdB - Ribonucleoside-diphosphate reductase subunit beta - Chlamydia pneumoniae - nrdB gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Indicus|evm.model.PRDE01054882.1.1 P20966 PTFBC_ECOLI 47.753 0.997151 0.623446 fruA - PTS system fructose-specific EIIB'BC component - Escherichia coli (strain K12) - fruA gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. Indicus|evm.model.PRDE01054885.1.1 A1B0E4 YIDC_PARDP 77.778 0.993464 0.240945 yidC - Membrane protein insertase YidC - Paracoccus denitrificans (strain Pd 1222) - yidC gene Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. Indicus|evm.model.PRDE01054958.1.1 Q2QVG9 CLPC2_ORYSJ 54.982 0.960573 0.303591 CLPC2 - Chaperone protein ClpC2, chloroplastic precursor - Oryza sativa subsp. japonica (Rice) - CLPC2 gene Molecular chaperone that may interact with a ClpP-like protease involved in degradation of denatured proteins in the chloroplast. Indicus|evm.model.PRDE01055202.1.1 Q6FEI9 GLNE_ACIAD 84.302 0.988439 0.187229 glnE - Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - glnE gene Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell. Indicus|evm.model.PRDE01055226.1.1 P58600 EPSC_RALSO 56.442 0.9 0.48 epsC - Probable UDP-N-acetylglucosamine 2-epimerase - Ralstonia solanacearum (strain GMI1000) - epsC gene May be involved in synthesis of N-acetyltrideoxygalactose, a component of exopolysaccharide EPS I which functions as a virulence factor. Indicus|evm.model.PRDE01055420.1.1 Q1QI02 HEMH_NITHX 61.364 0.988372 0.249275 hemH - Ferrochelatase - Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14) - hemH gene Catalyzes the ferrous insertion into protoporphyrin IX. Indicus|evm.model.PRDE01055439.1.2 A0R3S7 KU_MYCS2 53.608 0.7 0.849057 ku - Non-homologous end joining protein Ku - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - ku gene With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity. Indicus|evm.model.PRDE01055509.1.1 Q94DW6 SPZ1_ORYSJ 61.538 0.960396 0.245742 Os01g0765400 - Serpin-Z1 - Oryza sativa subsp. japonica (Rice) - Os01g0765400 gene Probable serine protease inhibitor. Indicus|evm.model.PRDE01055526.1.1 Q80WS3 FBLL1_MOUSE 64.583 0.913462 0.33121 Fbll1 - rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 - Mus musculus (Mouse) - Fbll1 gene S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). Indicus|evm.model.PRDE01055526.1.2 Q9FEF8 FBRL1_ARATH 69.767 0.723164 0.574675 FIB1 - rRNA 2'-O-methyltransferase fibrillarin 1 - Arabidopsis thaliana (Mouse-ear cress) - FIB1 gene S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (Probable). Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (Probable). Site specificity is provided by a guide RNA that base pairs with the substrate (Probable). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (Probable). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity). Binds monophosphate phosphoinositides in vitro (PubMed:29163603). Indicus|evm.model.PRDE01055572.1.1 Q02PG5 GAP2_PSEAB 64.848 0.993939 0.357918 gap2 - Glyceraldehyde-3-phosphate dehydrogenase-like protein - Pseudomonas aeruginosa (strain UCBPP-PA14) - gap2 gene Indicus|evm.model.PRDE01055580.1.1 Q8VPF1 PCAF_PSEKB 54.187 0.935185 0.538653 pcaF - Beta-ketoadipyl-CoA thiolase - Pseudomonas knackmussii (strain DSM 6978 / LMG 23759 / B13) - pcaF gene Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA. Indicus|evm.model.PRDE01055726.1.1 Q8FRR3 SYW_COREF 69.118 0.917808 0.210983 trpS - Tryptophan--tRNA ligase - Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) - trpS gene Catalyzes the attachment of tryptophan to tRNA(Trp). Indicus|evm.model.PRDE01055789.1.1 Q6NGT4 AHPD_CORDI 72.917 0.969388 0.563218 ahpD - Alkyl hydroperoxide reductase AhpD - Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) - ahpD gene Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Indicus|evm.model.PRDE01055834.1.1 B1W0K0 LSPA_STRGG 55.200 0.815789 0.77551 lspA - Lipoprotein signal peptidase - Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) - lspA gene This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Indicus|evm.model.PRDE01055849.1.1 B3QKU1 MASZ_RHOPT 70.745 0.994681 0.259669 glcB - Malate synthase G - Rhodopseudomonas palustris (strain TIE-1) - glcB gene Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA. Indicus|evm.model.PRDE01055875.1.1 P52626 PATH_VIBHA 60.714 0.847328 0.528226 patH - Putative amino-acid ABC transporter-binding protein PatH precursor - Vibrio harveyi - patH gene Probably part of a binding-protein-dependent transport system for an amino acid. Indicus|evm.model.PRDE01055881.1.1 P65173 Y1874_MYCBO 65.041 0.61 0.417537 guaB1 - Uncharacterized oxidoreductase Mb1874c - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - guaB1 gene Indicus|evm.model.PRDE01055898.1.1 Q9G4F5 CYSA_CUCSA 91.139 0.914634 0.234286 CYSA - Sulfate/thiosulfate import ATP-binding protein cysA - Cucumis sativus (Cucumber) - CYSA gene Part of the ABC transporter complex involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system (By similarity). Indicus|evm.model.PRDE01055986.1.1 Q9KUW9 METH_VIBCH 56.548 0.994048 0.137031 metH - Methionine synthase - Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) - metH gene Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). Indicus|evm.model.PRDE01055996.1.1 P22008 P5CR_PSEAE 37.607 0.97479 0.435897 proC - Pyrroline-5-carboxylate reductase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - proC gene Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. Indicus|evm.model.PRDE01056006.1.1 P96855 CHSE3_MYCTU 59.779 0.971119 0.389592 fadE34 - Acyl-CoA dehydrogenase FadE34 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - fadE34 gene Involved in the second cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. It contributes partly to the virulence by increasing the efficiency of beta-oxidation (PubMed:26161441). Catalyzes the dehydrogenation of the five-carbon steroid side chain of 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA) to yield 3-oxochol-4,22-dien-24-oyl-CoA (PubMed:26161441). Can also use 3beta-hydroxy-chol-5-ene-24-oyl-CoA, and shows weak activity with cholyl-CoA and deoxycholyl-CoA (PubMed:25645564). Indicus|evm.model.PRDE01056054.1.1 Q52991 YNF8_RHIML 62.857 0.244604 0.671498 Uncharacterized protein ORF8 in nfe locus - Rhizobium meliloti (Ensifer meliloti) Indicus|evm.model.PRDE01056065.1.1 Q0S7V5 FAD3_RHOJR 53.333 0.950355 0.273786 fadD3 - 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase - Rhodococcus jostii (strain RHA1) - fadD3 gene Involved in the catabolism of the rings C and D of cholesterol. Catalyzes the ATP-dependent CoA thioesterification of 3aalpha-H-4alpha(3'-propanoate)-7abeta-methylhexahydro-1,5-indanedione (HIP). Indicus|evm.model.PRDE01056095.1.1 Q9I3D2 ODO2_PSEAE 78.298 0.94332 0.603912 sucB - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - sucB gene E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Indicus|evm.model.PRDE01056105.1.1 O31714 K1PF_BACSU 51.724 0.850746 0.221122 fruK - 1-phosphofructokinase - Bacillus subtilis (strain 168) - fruK gene cytosol, 1-phosphofructokinase activity, phosphofructokinase activity Indicus|evm.model.PRDE01056153.1.1 G3XCV0 FLEQ_PSEAE 92.453 0.889831 0.240816 fleQ - Transcriptional regulator FleQ - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - fleQ gene AAA+ ATPase enhancer-binding protein that acts as a transcription regulator and plays a role in the modulation of mucin adhesion and flagellar gene expression (PubMed:9287015, PubMed:11673434, PubMed:26362077). In addition to flagella genes, regulates also expression of biofilm-related genes (PubMed:22581773). Functions as a transcriptional repressor in the absence of c-di-GMP and as an activator when c-di-GMP is present (PubMed:22581773). Indicus|evm.model.PRDE01056364.1.1 A1B3P3 SYM_PARDP 80.556 0.362245 0.342657 metG - Methionine--tRNA ligase - Paracoccus denitrificans (strain Pd 1222) - metG gene Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. Indicus|evm.model.PRDE01056368.1.1 Q8N8N0 RN152_HUMAN 90.152 0.992424 0.650246 RNF152 - E3 ubiquitin-protein ligase RNF152 - Homo sapiens (Human) - RNF152 gene E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937). Indicus|evm.model.PRDE01056394.1.1 Q05755 GLTB_AZOBR 64.072 0.873684 0.125413 gltB - Glutamate synthase [NADPH] large chain precursor - Azospirillum brasilense - gltB gene Indicus|evm.model.PRDE01056396.1.1 Q2JFF9 RS5_FRACC 86.275 0.60241 0.410891 rpsE - 30S ribosomal protein S5 - Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3) - rpsE gene With S4 and S12 plays an important role in translational accuracy. Indicus|evm.model.PRDE01056472.1.1 Q9ABX9 Y091_CAUVC 53.548 0.968553 0.196539 CC_0091 - Uncharacterized signaling protein CC_0091 - Caulobacter vibrioides (strain ATCC 19089 / CB15) - CC_0091 gene Indicus|evm.model.PRDE01056627.1.1 P9WNF9 ETHA_MYCTU 67.500 0.814433 0.198364 ethA - FAD-containing monooxygenase EthA - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ethA gene Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. Can act on long-chain aliphatic ketones (2-hexanone to 2-dodecanone) and on aromatic ketones (phenylacetone and benzylacetone). Is also able to catalyze enantioselective sulfoxidation of methyl-p-tolylsulfide. In vivo, likely functions as a BVMO, but the exact nature of the physiological substrate(s) remains to be established. Indicus|evm.model.PRDE01056770.1.1 Q6F860 SYT_ACIAD 93.284 0.992565 0.420312 thrS - Threonine--tRNA ligase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - thrS gene Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). Indicus|evm.model.PRDE01056782.1.1 O32115 YUTK_BACSU 46.053 0.993333 0.371287 yutK - Uncharacterized transporter YutK - Bacillus subtilis (strain 168) - yutK gene integral component of plasma membrane, nucleoside transmembrane transporter activity, symporter activity, nucleoside transmembrane transport Indicus|evm.model.PRDE01056795.1.1 P9WMW5 WECA_MYCTU 53.409 0.84466 0.25495 wecA - Decaprenyl-phosphate N-acetylglucosaminephosphotransferase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - wecA gene Involved in the biosynthesis of the disaccharide D-N-acetylglucosamine-L-rhamnose which plays an important role in the mycobacterial cell wall as a linker connecting arabinogalactan and peptidoglycan via a phosphodiester linkage. Catalyzes the transfer of the N-acetylglucosamine-1-phosphate (GlcNAc-1P) moiety from UDP-GlcNAc onto the carrier lipid decaprenyl phosphate (C50-P), yielding GlcNAc-pyrophosphoryl-decaprenyl (GlcNAc-PP-C50). Indicus|evm.model.PRDE01056846.1.1 Q54UU8 TRXB_DICDI 67.308 0.809524 0.197492 trrA - Thioredoxin reductase - Dictyostelium discoideum (Slime mold) - trrA gene thioredoxin-disulfide reductase activity, cell redox homeostasis, culmination involved in sorocarp development, phagocytosis Indicus|evm.model.PRDE01056919.1.1 Q5NNQ0 ASSY_ZYMMO 82.667 0.948718 0.191176 argG - Argininosuccinate synthase - Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) - argG gene Indicus|evm.model.PRDE01056923.1.1 A0R022 PBPB_MYCS2 66.463 0.990712 0.498457 pbpB - Penicillin-binding protein PbpB - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - pbpB gene Indicus|evm.model.PRDE01056924.1.1 A4FKE3 RL20_SACEN 85.714 0.565574 1 rplT - 50S ribosomal protein L20 - Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) - rplT gene Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. Indicus|evm.model.PRDE01056924.1.2 P9WKJ9 IF3_MYCTU 79.310 0.826087 0.343284 infC - Translation initiation factor IF-3 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - infC gene IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. Indicus|evm.model.PRDE01056975.1.1 P9WQ91 ALAA_MYCTU 64.885 0.896552 0.337995 aspC - Alanine aminotransferase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - aspC gene plasma membrane Indicus|evm.model.PRDE01057017.1.2 P9WNU3 EX53_MYCTU 51.042 0.988889 0.283019 Rv2090 - 5'-3' exonuclease - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv2090 gene 5'-3' exonuclease acting preferentially on double-stranded DNA. Indicus|evm.model.PRDE01057034.1.1 B0SUP8 RPOC_CAUSK 93.694 0.990991 0.079627 rpoC - DNA-directed RNA polymerase subunit beta' - Caulobacter sp. (strain K31) - rpoC gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01057034.1.2 Q11HB3 RPOB_CHESB 90.000 0.971831 0.0514866 rpoB - DNA-directed RNA polymerase subunit beta - Chelativorans sp. (strain BNC1) - rpoB gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01057095.1.1 A5CM86 DNAK_CLAM3 89.744 0.256757 0.23756 dnaK - Chaperone protein DnaK - Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382) - dnaK gene Acts as a chaperone. Indicus|evm.model.PRDE01057268.1.1 F9UTW9 GLPF3_LACPL 53.448 0.946058 1.00417 glpF3 - Glycerol uptake facilitator protein 3 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - glpF3 gene Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol and H(2)O(2). Is not permeable to urea and D/L-lactic acid. Indicus|evm.model.PRDE01057268.1.2 A5CS23 GLPK_CLAM3 81.000 0.970588 0.20198 glpK - Glycerol kinase - Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382) - glpK gene Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate. Indicus|evm.model.PRDE01057269.1.1 C5C1C4 GLPK_BEUC1 67.677 0.731343 0.265347 glpK - Glycerol kinase - Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432) - glpK gene Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate. Indicus|evm.model.PRDE01057289.1.1 Q9HZ67 CMPDT_PSEAE 60.938 0.892523 0.586301 pheA - Bifunctional chorismate mutase/prephenate dehydratase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pheA gene Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. Indicus|evm.model.PRDE01057380.1.1 Q6ABX8 ODPB_LEIXX 59.278 0.994845 0.575668 pdhB - Pyruvate dehydrogenase E1 component subunit beta - Leifsonia xyli subsp. xyli (strain CTCB07) - pdhB gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Indicus|evm.model.PRDE01057385.1.1 P9WMZ7 AFTC_MYCTU 50.318 0.905325 0.3903 aftC - Alpha-(1->3)-arabinofuranosyltransferase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - aftC gene Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG. It can also use (Z,Z)-farnesylphosphoryl D-arabinose (Z-FPA), and to a lesser extent (E,E,Z,Z,Z,Z)-heptaprenylphosphoryl D-arabinose (Z-HPA) and (Z)-nerylphosphoryl D-arabinose (Z-NPA) as sugar donors. Indicus|evm.model.PRDE01057424.1.1 B8H630 ERA_CAUVN 86.047 0.934066 0.287975 era - GTPase Era - Caulobacter vibrioides (strain NA1000 / CB15N) - era gene An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. Indicus|evm.model.PRDE01057613.1.1 P9WNG5 FABD_MYCTU 53.704 0.80303 0.218543 fabD - Malonyl CoA-acyl carrier protein transacylase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - fabD gene cytosol, fatty acid synthase complex, [acyl-carrier-protein] S-malonyltransferase activity, fatty acid biosynthetic process Indicus|evm.model.PRDE01057623.1.1 B8G8T1 PYRR_CHLAD 76.250 0.6875 0.615385 pyrR - Bifunctional protein PyrR - Chloroflexus aggregans (strain MD-66 / DSM 9485) - pyrR gene Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. Indicus|evm.model.PRDE01057632.1.1 I6WZK7 MMCO_MYCTU 44.762 0.970874 0.204365 mmcO - Multicopper oxidase MmcO precursor - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - mmcO gene Required for copper resistance. In vitro, oxidizes organic substrates and Fe(2+). May act in vivo by oxidation of toxic periplasmic Cu(+). Indicus|evm.model.PRDE01057701.1.1 Q79VE2 GLNE_CORGL 64.286 0.993506 0.147368 glnE - Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - glnE gene Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell. Indicus|evm.model.PRDE01057739.1.1 Q73YK4 GCST_MYCPA 61.364 0.977612 0.365123 gcvT - Aminomethyltransferase - Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) - gcvT gene The glycine cleavage system catalyzes the degradation of glycine. Indicus|evm.model.PRDE01057793.1.1 Q9M223 UTP11_ARATH 46.575 0.369231 0.855263 At3g60360 - Probable U3 small nucleolar RNA-associated protein 11 - Arabidopsis thaliana (Mouse-ear cress) - At3g60360 gene Involved in nucleolar processing of pre-18S ribosomal RNA. Indicus|evm.model.PRDE01057811.1.1 Q9KWV3 TTGF_PSEPT 53.020 0.96732 0.31875 ttgF - Toluene efflux pump outer membrane protein TtgF precursor - Pseudomonas putida (strain DOT-T1E) - ttgF gene The outer membrane component of an inducible organic solvent efflux pump. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux. Indicus|evm.model.PRDE01057875.1.1 Q03460 GLSN_MEDSA 67.470 0.840426 0.0428441 Glutamate synthase [NADH], amyloplastic precursor - Medicago sativa (Alfalfa) Indicus|evm.model.PRDE01057908.1.1 P76079 PAAC_ECOLI 53.030 0.984615 0.262097 paaC - 1,2-phenylacetyl-CoA epoxidase, subunit C - Escherichia coli (strain K12) - paaC gene Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit C may be essential for structural integrity of the alpha subunit. Indicus|evm.model.PRDE01057942.1.1 C5CC70 RPOC_MICLC 97.170 0.99061 0.164099 rpoC - DNA-directed RNA polymerase subunit beta' - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - rpoC gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01057970.1.1 P43885 SERA_HAEIN 57.658 0.973451 0.27561 serA - D-3-phosphoglycerate dehydrogenase - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - serA gene Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. Indicus|evm.model.PRDE01057999.1.1 P16700 CYSP_ECOLI 57.895 0.822222 0.399408 cysP - Thiosulfate-binding protein precursor - Escherichia coli (strain K12) - cysP gene Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport. Indicus|evm.model.PRDE01058043.1.1 P13511 CZCA_CUPMC 58.216 0.995305 0.200376 czcA - Cobalt-zinc-cadmium resistance protein CzcA - Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) - czcA gene Has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance. CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete CZC efflux system (CzcABC). Indicus|evm.model.PRDE01058104.1.2 A0QMH2 ILVD_MYCA1 93.396 0.875 0.208696 ilvD - Dihydroxy-acid dehydratase - Mycobacterium avium (strain 104) - ilvD gene Indicus|evm.model.PRDE01058199.1.1 P44907 RNR_HAEIN 47.863 0.983051 0.150895 rnr - Ribonuclease R - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - rnr gene 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Indicus|evm.model.PRDE01058331.1.1 Q9R9N3 ODP2_RHIME 53.684 0.762712 0.263982 pdhC - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - pdhC gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Indicus|evm.model.PRDE01058393.1.1 Q73ZM8 PHK_MYCPA 75.781 0.84106 0.187811 MAP_1573c - Probable phosphoketolase - Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) - MAP_1573c gene Indicus|evm.model.PRDE01058543.1.1 Q312S1 DCTMQ_DESAG 55.405 0.9125 0.125984 dctMQ - Isethionate TRAP transporter permease protein DctMQ - Desulfovibrio alaskensis (strain ATCC BAA 1058 / DSM 17464 / G20) - dctMQ gene Part of the tripartite ATP-independent periplasmic (TRAP) transport system DctPQM involved in the uptake of isethionate (2-hydroxyethanesulfonate), which is then catabolized by enzymes encoded by adjacent genes in the locus. Thereby is involved in an anaerobic respiration pathway that converts the sulfonate isethionate to ammonia, acetate and sulfide. Indicus|evm.model.PRDE01058572.1.1 E1V6K4 TRKI_HALED 47.115 0.895652 0.23374 trkI - Trk system potassium uptake protein TrkI - Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9) - trkI gene Medium-affinity potassium transport system. Probably interacts with Trk system potassium uptake protein TrkA. Main K(+) transporter in osmotically adapted cells. Indicus|evm.model.PRDE01058665.1.1 O21241 NDUS1_RECAM 72.840 0.993827 0.234443 NAD11 - NADH-ubiquinone oxidoreductase 75 kDa subunit - Reclinomonas americana - NAD11 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By similarity). Indicus|evm.model.PRDE01058775.1.1 Q9KE51 HTPG_BACHD 77.895 0.989474 0.152 htpG - Chaperone protein HtpG - Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) - htpG gene Molecular chaperone. Has ATPase activity. Indicus|evm.model.PRDE01058792.1.1 A9WNC6 ATPA_RENSM 70.940 0.983051 0.216514 atpA - ATP synthase subunit alpha - Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) - atpA gene Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Indicus|evm.model.PRDE01058823.1.1 B0V899 NUOCD_ACIBY 92.823 0.990476 0.352941 nuoC - NADH-quinone oxidoreductase subunit C/D - Acinetobacter baumannii (strain AYE) - nuoC gene NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Indicus|evm.model.PRDE01058826.1.1 P23612 SYWC_RABIT 53.535 0.899083 0.229474 WARS1 - Tryptophan--tRNA ligase, cytoplasmic - Oryctolagus cuniculus (Rabbit) - WARS1 gene T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). Indicus|evm.model.PRDE01058925.1.1 B1HMW8 RL5_LYSSC 80.952 0.976471 0.47486 rplE - 50S ribosomal protein L5 - Lysinibacillus sphaericus (strain C3-41) - rplE gene This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. Indicus|evm.model.PRDE01059050.1.1 P55503 Y4JC_SINFN 54.167 0.903846 0.444444 NGR_a03130 - Uncharacterized protein y4jC - Sinorhizobium fredii (strain NBRC 101917 / NGR234) - NGR_a03130 gene Indicus|evm.model.PRDE01059156.1.1 B0V4V6 DER_ACIBY 95.294 0.857143 0.208955 der - GTPase Der - Acinetobacter baumannii (strain AYE) - der gene GTPase that plays an essential role in the late steps of ribosome biogenesis. Indicus|evm.model.PRDE01059167.1.1 C5CCF1 CARB_MICLC 91.971 0.978417 0.126249 carB - Carbamoyl-phosphate synthase large chain - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - carB gene Indicus|evm.model.PRDE01059195.1.1 Q05755 GLTB_AZOBR 77.953 0.954545 0.0871287 gltB - Glutamate synthase [NADPH] large chain precursor - Azospirillum brasilense - gltB gene Indicus|evm.model.PRDE01059363.1.1 P0C186 PNTAA_RHORU 57.343 0.928105 0.398438 pntAA - NAD(P) transhydrogenase subunit alpha part 1 - Rhodospirillum rubrum - pntAA gene The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. Indicus|evm.model.PRDE01059367.1.1 P9WN97 FTSW_MYCTU 48.718 0.828571 0.267176 ftsW - Probable peptidoglycan glycosyltransferase FtsW - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ftsW gene Peptidoglycan polymerase that is essential for cell division. Indicus|evm.model.PRDE01059425.1.1 Q27710 CATA_ONCVE 46.497 0.987179 0.323651 cat - Catalase - Onchocerca volvulus endobacterium - cat gene Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Indicus|evm.model.PRDE01059456.1.1 P0ADE6 KBP_ECOLI 54.688 0.887324 0.47651 kbp - Potassium binding protein Kbp - Escherichia coli (strain K12) - kbp gene Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+) (PubMed:27112601). May be involved in the regulation of peptidoglycan cross-linking (PubMed:25422305). Indicus|evm.model.PRDE01059521.1.2 P55626 Y4QE_SINFN 60.465 0.792453 0.135897 NGR_a01930 - Putative transposase y4qE - Sinorhizobium fredii (strain NBRC 101917 / NGR234) - NGR_a01930 gene Indicus|evm.model.PRDE01059541.1.1 A7HY57 TIG_PARL1 52.113 0.978571 0.273973 tig - Trigger factor - Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) - tig gene Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. Indicus|evm.model.PRDE01059549.1.1 Q50049 DUS_MYCLE 55.346 0.863388 0.476562 dus - Probable tRNA-dihydrouridine synthase - Mycobacterium leprae (strain TN) - dus gene Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Indicus|evm.model.PRDE01059571.1.1 Q58CU6 CA198_BOVIN 99.074 0.681529 0.483077 Uncharacterized protein C1orf198 homolog - Bos taurus (Bovine) Indicus|evm.model.PRDE01059587.1.1 A0QLT3 THIG_MYCA1 80.000 0.992308 0.515873 thiG - Thiazole synthase - Mycobacterium avium (strain 104) - thiG gene Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. Indicus|evm.model.PRDE01059609.1.1 C7JGP5 SDHE_ACEP3 82.353 0.815534 0.944954 sdhE - FAD assembly factor SdhE - Acetobacter pasteurianus (strain NBRC 3283 / LMG 1513 / CCTM 1153) - sdhE gene An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins (Probable). Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (By similarity). Required for flavinylation of SdhA, when the SDH operon and this gene are overexpressed in G.oxydans. Flavinylation of SdhA is detected only in the presence of sdhE. Indicus|evm.model.PRDE01059687.1.1 Q0SH62 PROA_RHOJR 72.376 0.825688 0.527845 proA - Gamma-glutamyl phosphate reductase - Rhodococcus jostii (strain RHA1) - proA gene Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Indicus|evm.model.PRDE01059721.1.1 Q8NM65 PK21B_CORGL 97.561 0.975904 0.271242 ppk2B - Polyphosphate kinase PPK2B - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - ppk2B gene Catalyzes the synthesis of polyP from ATP or GTP. Can also use inorganic polyphosphate (polyP) as a donor to convert ADP to ATP, but the activity is 10-fold higher in vitro for polyP synthesis than for ATP formation. Indicus|evm.model.PRDE01059751.1.1 O69730 TCRX_MYCTU 54.610 0.932886 0.636752 tcrX - Probable transcriptional regulatory protein TcrX - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - tcrX gene Member of the two-component regulatory system TcrY/TcrX. Indicus|evm.model.PRDE01059790.1.1 A0QYG9 SECA2_MYCS2 52.941 0.989899 0.252551 secA2 - Protein translocase subunit SecA 2 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - secA2 gene Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Indicus|evm.model.PRDE01059834.1.1 P33008 ALDH_PSESP 48.649 0.982143 0.229508 terPE - Probable aldehyde dehydrogenase - Pseudomonas sp. - terPE gene Involved in an alpha-terpineol oxidation system. Indicus|evm.model.PRDE01059838.1.1 P45173 Y1349_HAEIN 64.444 0.872549 0.6375 HI_1349 - Uncharacterized protein HI_1349 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_1349 gene Indicus|evm.model.PRDE01059969.1.1 Q9AC20 IPYR_CAUVC 64.368 0.816038 1.19774 ppa - Inorganic pyrophosphatase - Caulobacter vibrioides (strain ATCC 19089 / CB15) - ppa gene Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Indicus|evm.model.PRDE01059984.1.1 Q8VD52 PLPP_RAT 46.479 0.636364 0.355987 Pdxp - Chronophin - Rattus norvegicus (Rat) - Pdxp gene Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine. Indicus|evm.model.PRDE01060009.1.1 Q8RAS5 HFLX_CALS4 57.480 0.809211 0.35514 hflX - GTPase HflX - Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) - hflX gene GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Indicus|evm.model.PRDE01060074.1.1 Q01838 P60_LISSE 50.617 0.757576 0.189293 iap - Probable endopeptidase p60 precursor - Listeria seeligeri - iap gene This major extracellular protein may be involved in the invasion of non-professional phagocytic cells by Listeria. Indicus|evm.model.PRDE01060238.1.1 A1R6I0 COXX_PAEAT 70.312 0.846667 0.46875 ctaB - Protoheme IX farnesyltransferase - Paenarthrobacter aurescens (strain TC1) - ctaB gene Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. Indicus|evm.model.PRDE01060594.1.1 H8ZPX2 SAPD_PSESP 53.896 0.858757 0.371069 ald - 3-succinoylsemialdehyde-pyridine dehydrogenase - Pseudomonas sp. - ald gene Catalyzes the dehydrogenation of 3-succinoylsemialdehyde-pyridine to 3-succinoyl-pyridine in the nicotine degradation pathway. Indicus|evm.model.PRDE01060646.1.1 P32473 ODPB_YEAST 72.897 0.540816 0.535519 PDB1 - Pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - PDB1 gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Indicus|evm.model.PRDE01060687.1.1 Q9XA86 MMPLD_STRCO 77.528 0.956522 0.130496 SCO0839 - Putative membrane protein SCO0839 - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - SCO0839 gene Indicus|evm.model.PRDE01060834.1.1 A3QP08 TS1R2_SAISC 81.513 0.991597 0.142686 TAS1R2 - Taste receptor type 1 member 2 precursor - Saimiri sciureus (Common squirrel monkey) - TAS1R2 gene Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity). Indicus|evm.model.PRDE01060925.1.1 A0JUP3 PYRH_ARTS2 80.952 0.832 0.510204 pyrH - Uridylate kinase - Arthrobacter sp. (strain FB24) - pyrH gene Catalyzes the reversible phosphorylation of UMP to UDP. Indicus|evm.model.PRDE01060945.1.1 B8GZS3 SYC_CAUVN 75.294 0.988235 0.183585 cysS - Cysteine--tRNA ligase - Caulobacter vibrioides (strain NA1000 / CB15N) - cysS gene Indicus|evm.model.PRDE01061006.1.1 P9WG03 SUGA_MYCTU 54.839 0.904412 0.442997 sugA - Trehalose transport system permease protein SugA - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - sugA gene Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for the translocation of the substrate across the membrane. Indicus|evm.model.PRDE01061014.1.1 A0QX93 TRPE_MYCS2 68.519 0.993827 0.30916 trpE - Anthranilate synthase component 1 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - trpE gene Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity). Indicus|evm.model.PRDE01061108.1.1 Q28MN1 GLGC_JANSC 74.194 0.991935 0.296651 glgC - Glucose-1-phosphate adenylyltransferase - Jannaschia sp. (strain CCS1) - glgC gene Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. Indicus|evm.model.PRDE01061187.1.1 P0CL04 RHTA_SALTY 47.727 0.992308 0.440678 rhtA - Threonine/homoserine exporter RhtA - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - rhtA gene Involved in the efflux of threonine and homoserine. Indicus|evm.model.PRDE01061319.1.1 A0A0H2ZF87 TRMJ_PSEAB 52.206 0.985401 0.533074 trmJ - tRNA (cytidine/uridine/adenosine-2'-O-)-methyltransferase TrmJ - Pseudomonas aeruginosa (strain UCBPP-PA14) - trmJ gene Catalyzes the formation of 2'O-methylated cytidine (Cm32), 2'O-methylated uridine (Um32) or 2'O-methylated adenosine (Am32) at position 32 in tRNA. Confers resistance to oxidative stress. Indicus|evm.model.PRDE01061396.1.1 Q57498 Y1053_HAEIN 67.164 0.536585 1.0885 HI_1053 - Uncharacterized protein HI_1053 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_1053 gene oxidoreductase activity Indicus|evm.model.PRDE01061492.1.1 B6IQ27 PYRG_RHOCS 79.310 0.97191 0.328413 pyrG - CTP synthase - Rhodospirillum centenum (strain ATCC 51521 / SW) - pyrG gene Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. Indicus|evm.model.PRDE01061589.1.1 Q8CQK0 WALR_STAES 68.627 0.990196 0.437768 walR - Transcriptional regulatory protein WalR - Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) - walR gene Member of the two-component regulatory system WalK/WalR. Indicus|evm.model.PRDE01061606.1.1 B0VEG5 TRHO_ACIBY 93.810 0.990521 0.671975 trhO - tRNA uridine(34) hydroxylase - Acinetobacter baumannii (strain AYE) - trhO gene Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. Indicus|evm.model.PRDE01061639.1.1 Q9HZK8 NQRC_PSEAE 70.079 0.976744 0.494253 nqrC - Na(+)-translocating NADH-quinone reductase subunit C - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - nqrC gene NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. Indicus|evm.model.PRDE01061819.1.1 B8HAS8 ILVC_PSECP 73.333 0.981132 0.31085 ilvC - Ketol-acid reductoisomerase (NADP(+)) - Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) - ilvC gene Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. Indicus|evm.model.PRDE01061909.1.1 Q9PQQ8 RL23_UREPA 47.727 0.464088 1.72381 rplW - 50S ribosomal protein L23 - Ureaplasma parvum serovar 3 (strain ATCC 700970) - rplW gene One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome. Indicus|evm.model.PRDE01061959.1.1 G3XD28 PILM_PSEAE 45.783 0.992593 0.381356 pilM - Type IV pilus inner membrane component PilM - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pilM gene Inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. PilN/PilO heterodimers form the foundation of the inner-membrane PilM/PilN/PilO/PilP complex which plays an essential role in the assembly of a functional T4 pilus (PubMed:19857645, PubMed:19857646). In turn, associates with PilN and facilitates PilM functionally relevant structural changes that differentially impacts PilM binding to PilB, PilT, and PilC (PubMed:27022027). Indicus|evm.model.PRDE01061966.1.1 P07778 YPQL_ACICA 53.086 0.569343 0.671569 Uncharacterized protein in pqq-V 5'region - Acinetobacter calcoaceticus Indicus|evm.model.PRDE01062084.1.1 O05087 Y1728_HAEIN 58.416 0.990099 0.254408 HI_1728 - Uncharacterized membrane protein HI_1728 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_1728 gene cadmium ion transmembrane transporter activity, manganese ion transmembrane transporter activity Indicus|evm.model.PRDE01062125.1.1 Q5LXA4 GREA_RUEPO 67.123 0.986301 0.467949 greA - Transcription elongation factor GreA - Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) - greA gene Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. Indicus|evm.model.PRDE01062242.1.1 P75823 LTAE_ECOLI 72.685 0.972851 0.663664 ltaE - Low specificity L-threonine aldolase - Escherichia coli (strain K12) - ltaE gene Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. L-threo-phenylserine and L-erythro-phenylserine are also good substrates. Indicus|evm.model.PRDE01062282.1.1 O88018 TAL1_STRCO 62.687 0.916667 0.188976 tal1 - Transaldolase 1 - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - tal1 gene Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Indicus|evm.model.PRDE01062464.1.1 P9WQB1 DHA_MYCTU 64.912 0.982456 0.153639 ald - Alanine dehydrogenase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ald gene Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer. Indicus|evm.model.PRDE01062802.1.1 Q0S962 PATR_RHOJR 58.779 0.948905 0.382682 pat - Putative phenylalanine aminotransferase - Rhodococcus jostii (strain RHA1) - pat gene May catalyze the transamination reaction in phenylalanine biosynthesis. Indicus|evm.model.PRDE01062806.1.1 P41403 AK_MYCSM 72.000 0.988571 0.415677 ask - Aspartokinase - Mycolicibacterium smegmatis - ask gene Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine. Indicus|evm.model.PRDE01062828.1.2 C1D0F7 GCST_DEIDV 88.235 0.988235 0.238095 gcvT - Aminomethyltransferase - Deinococcus deserti (strain DSM 17065 / CIP 109153 / LMG 22923 / VCD115) - gcvT gene The glycine cleavage system catalyzes the degradation of glycine. Indicus|evm.model.PRDE01062905.1.1 Q9CDL9 GLN1A_LACLA 59.155 0.985915 0.159193 glnA - Glutamine synthetase - Lactococcus lactis subsp. lactis (strain IL1403) - glnA gene Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes. Indicus|evm.model.PRDE01063319.1.1 C5CC56 RS3_MICLC 97.248 0.990826 0.400735 rpsC - 30S ribosomal protein S3 - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - rpsC gene Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. Indicus|evm.model.PRDE01063345.1.1 Q51062 YHGF_NEIGO 48.837 0.451613 0.122853 tex - Transcriptional accessory protein Tex - Neisseria gonorrhoeae - tex gene Indicus|evm.model.PRDE01063799.1.1 Q5YYH7 SYFA_NOCFA 66.892 0.7 0.614035 pheS - Phenylalanine--tRNA ligase alpha subunit - Nocardia farcinica (strain IFM 10152) - pheS gene Indicus|evm.model.PRDE01063809.1.1 Q4JX07 CLPS_CORJK 75.342 0.626087 1.13861 clpS - ATP-dependent Clp protease adapter protein ClpS - Corynebacterium jeikeium (strain K411) - clpS gene Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. Indicus|evm.model.PRDE01063817.1.1 P66967 Y1314_MYCBO 40.299 0.460993 0.433846 BQ2027_MB1314C - Putative peptide transport permease protein Mb1314c - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - BQ2027_MB1314C gene Indicus|evm.model.PRDE01063954.1.1 P40811 ILVI_SALTY 53.571 0.877419 0.270035 ilvI - Acetolactate synthase isozyme 3 large subunit - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - ilvI gene acetolactate synthase complex, acetolactate synthase activity, flavin adenine dinucleotide binding, isoleucine biosynthetic process, valine biosynthetic process Indicus|evm.model.PRDE01063971.1.1 Q8A1E7 PROB_BACTN 67.669 0.985075 0.372222 proB - Glutamate 5-kinase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - proB gene Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. Indicus|evm.model.PRDE01064043.1.1 Q8G0J9 PPI1_BRUSU 51.282 0.807407 0.688776 ppi - Probable peptidyl-prolyl cis-trans isomerase precursor - Brucella suis biovar 1 (strain 1330) - ppi gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Indicus|evm.model.PRDE01064043.1.2 A5V282 QUEA_SPHWW 75.000 0.981818 0.159884 queA - S-adenosylmethionine:tRNA ribosyltransferase-isomerase - Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) - queA gene Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). Indicus|evm.model.PRDE01064084.1.1 Q9X8R6 ALF_STRCO 80.000 0.964286 0.163265 fba - Fructose-bisphosphate aldolase - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - fba gene Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. Indicus|evm.model.PRDE01064131.1.1 Q9CID5 TREPP_LACLA 54.902 0.588235 0.110533 trePP - Trehalose 6-phosphate phosphorylase - Lactococcus lactis subsp. lactis (strain IL1403) - trePP gene Catalyzes the conversion of trehalose 6-phosphate into glucose 1-phosphate and glucose 6-phosphate. Indicus|evm.model.PRDE01064131.1.2 P9WN15 Y2006_MYCTU 63.158 0.961538 0.0587792 Rv2006 - Uncharacterized glycosyl hydrolase Rv2006 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv2006 gene cell wall, extracellular region, plasma membrane, hydrolase activity, hydrolyzing O-glycosyl compounds, carbohydrate metabolic process Indicus|evm.model.PRDE01064193.1.1 P31860 GYRB_RHOCA 90.083 0.863309 1.03731 gyrB - DNA gyrase subunit B - Rhodobacter capsulatus - gyrB gene A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. Indicus|evm.model.PRDE01064254.1.1 Q02FG6 PUR9_PSEAB 71.053 0.993243 0.276636 purH - Bifunctional purine biosynthesis protein PurH - Pseudomonas aeruginosa (strain UCBPP-PA14) - purH gene Indicus|evm.model.PRDE01064320.1.1 A1ATI8 DAPA_PELPD 58.730 0.968992 0.444828 dapA - 4-hydroxy-tetrahydrodipicolinate synthase - Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1) - dapA gene Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). Indicus|evm.model.PRDE01064341.1.1 B8GWU1 NUOK_CAUVN 89.412 0.4 2.07921 nuoK - NADH-quinone oxidoreductase subunit K - Caulobacter vibrioides (strain NA1000 / CB15N) - nuoK gene NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Indicus|evm.model.PRDE01064389.1.1 P9WFP5 Y1462_MYCTU 78.824 0.933333 0.2267 Rv1462 - UPF0051 protein Rv1462 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1462 gene response to host immune response Indicus|evm.model.PRDE01064523.1.1 P9WGD5 SSB_MYCTU 73.913 0.405405 0.676829 ssb - Single-stranded DNA-binding protein - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ssb gene extracellular region, nucleoid, plasma membrane, single-stranded DNA binding, cellular response to DNA damage stimulus, positive regulation of helicase activity, response to antibiotic Indicus|evm.model.PRDE01064616.1.1 B2HUI9 COAX_ACIBC 75.926 0.990654 0.438525 coaX - Type III pantothenate kinase - Acinetobacter baumannii (strain ACICU) - coaX gene Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Indicus|evm.model.PRDE01064715.1.1 F9XMW6 T4HR_ZYMTI 55.738 0.909091 0.247191 MYCGRDRAFT_87994 - Probable tetrahydroxynaphthalene reductase MYCGRDRAFT_87994 - Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) - MYCGRDRAFT_87994 gene Probable tetrahydroxynaphthalene reductase; part of the gene cluster 29 that mediates the biosynthesis dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall (PubMed:28818040). Catalyzes the NADPH-dependent reduction of 1,3,6,8-tetrahydroxynaphthalene (T4HN) into (+)-scytalone (By similarity). Indicus|evm.model.PRDE01064715.1.2 P71534 MABA_MYCS2 64.706 0.976744 0.337255 mabA - 3-oxoacyl-[acyl-carrier-protein] reductase MabA - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - mabA gene Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis (By similarity). Catalyzes the NADPH-dependent reduction of beta-ketoacyl derivatives, the second step of the FAS-II elongation cycle (By similarity). Has a preference for longer substrates (PubMed:29717709). Can use CoA derivatives as substrates in vitro (PubMed:29717709). Indicus|evm.model.PRDE01065122.1.1 Q8PH20 HPPA_XANAC 79.747 0.986928 0.226667 hppA - K(+)-insensitive pyrophosphate-energized proton pump - Xanthomonas axonopodis pv. citri (strain 306) - hppA gene Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. Indicus|evm.model.PRDE01065142.1.1 Q7MUD3 SYI_PORGI 76.056 0.985915 0.062445 ileS - Isoleucine--tRNA ligase - Porphyromonas gingivalis (strain ATCC BAA-308 / W83) - ileS gene Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Indicus|evm.model.PRDE01065204.1.1 P47734 FADH_METMR 52.609 0.843511 0.671795 fdh - S-(hydroxymethyl)glutathione dehydrogenase - Methylobacter marinus - fdh gene Indicus|evm.model.PRDE01065511.1.1 P9WQ39 MENE_MYCTU 50.838 0.950549 0.491892 menE - Probable 2-succinylbenzoate--CoA ligase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - menE gene Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). May be involved in the biosynthesis of menaquinone (By similarity). Indicus|evm.model.PRDE01065646.1.1 Q1B827 SECA2_MYCSS 61.494 0.994186 0.222222 secA2 - Protein translocase subunit SecA 2 - Mycobacterium sp. (strain MCS) - secA2 gene Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Indicus|evm.model.PRDE01065653.1.1 Q8Y4I4 GPMI_LISMO 49.265 0.964286 0.27451 gpmI - 2,3-bisphosphoglycerate-independent phosphoglycerate mutase - Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) - gpmI gene Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Indicus|evm.model.PRDE01065734.1.1 A0R152 RNE_MYCS2 73.333 0.994444 0.173578 rne - Ribonuclease E - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - rne gene Endoribonuclease that plays a central role in RNA processing and decay. Plays a major role in pre-16S rRNA maturation, probably generating the mature 5'-end, and a minor role in pre-5S and pre-23S rRNA maturation (PubMed:22014150). Probably also processes tRNA (By similarity). Indicus|evm.model.PRDE01065842.1.1 P94535 GLCD_BACSU 45.223 0.922619 0.357447 glcD - Glycolate oxidase subunit GlcD - Bacillus subtilis (strain 168) - glcD gene Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is also able to oxidize D-lactate ((R)-lactate). Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown. Indicus|evm.model.PRDE01065932.1.1 Q7WUM3 MAK_ACTMI 54.795 0.86747 0.189931 mak1 - Maltokinase - Actinoplanes missouriensis - mak1 gene Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Only maltose acts effectively as phosphoryl-group acceptor, but maltotriose, maltotetraose, maltopentaose, and maltohexaose show a weak potential to replace maltose. ATP is not replaceable as phosphoryl-group donor. Indicus|evm.model.PRDE01065954.1.1 Q84LK3 BADH2_ORYSJ 52.941 0.900763 0.260437 BADH2 - Betaine aldehyde dehydrogenase 2 - Oryza sativa subsp. japonica (Rice) - BADH2 gene Dehydrogenase that can use N-acetyl-gamma-aminobutyraldehyde (NAGABald), gamma-guanidinobutyraldehyde (GGBald), betaine aldehyde (Bet-ald), gamma-aminobutyraldehyde (GAB-ald), acetaldehyde, 4-aminobutylaldehyde (AB-ald), 3-aminopropionaldehyde (AP-ald), 4-N-trimethylaminobutyraldehyde (TMAB-ald) and 3-N-trimethylaminopropionaldehyde (TMAP-ald) as substrates. Catalyzes the oxidation of GAB-ald more efficiently than Bet-ald. Mediates the conversion of GAB-ald into gamma-aminobutyric acid (GABA), and prevents the formation of 2-acetyl-1-pyrroline (2AP) which gives fragrant rice its aromatic properties. Indicus|evm.model.PRDE01066032.1.1 Q8NML3 RAMA_CORGL 70.526 0.979167 0.341637 ramA - HTH-type transcriptional activator RamA - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - ramA gene RamA is a master regulator of acetate metabolism. It positively controls the expression of acnA, aceA, aceB, ack, pta and ramB genes in the presence of acetate (PubMed:16547043, PubMed:17114251, PubMed:19095019). RamA is also a positive regulator of rpf2 gene expression during growth on glucose as the sole carbon source (PubMed:18355281). Indicus|evm.model.PRDE01066040.1.1 P73511 PHSG_SYNY3 80.282 0.299107 0.26384 glgP - Glycogen phosphorylase - Synechocystis sp. (strain PCC 6803 / Kazusa) - glgP gene Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). Indicus|evm.model.PRDE01066257.1.1 P9WP97 COBB_MYCTU 65.649 0.992366 0.286652 cobB - Hydrogenobyrinate a,c-diamide synthase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - cobB gene Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source. Indicus|evm.model.PRDE01066513.1.1 P54919 HEM2_STRCO 69.714 0.982857 0.530303 hemB - Delta-aminolevulinic acid dehydratase - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - hemB gene Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). Indicus|evm.model.PRDE01066666.1.1 O75069 TMCC2_HUMAN 92.754 0.985507 0.0973202 TMCC2 - Transmembrane and coiled-coil domains protein 2 - Homo sapiens (Human) - TMCC2 gene May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. Indicus|evm.model.PRDE01066747.1.1 P9WMF5 LYSG_MYCTU 65.306 0.648649 0.244224 lysG - HTH-type transcriptional regulator LysG - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - lysG gene Positively regulates the expression of the exporter LysE and represses its own expression. Activity requires the presence of a coinducer, lysine or histidine. Acts by binding to lysG-lysE promoter region. Also up-regulates the expression of ppsB, ppsC and ppsD, by binding to the upstream region of ppsB. Indicus|evm.model.PRDE01066793.1.1 Q7MMN0 ZNUC_VIBVY 51.923 0.689189 0.283525 znuC - Zinc import ATP-binding protein ZnuC - Vibrio vulnificus (strain YJ016) - znuC gene Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01066853.1.1 A0LTK3 THIE_ACIC1 63.303 0.830769 0.613208 thiE - Thiamine-phosphate synthase - Acidothermus cellulolyticus (strain ATCC 43068 / 11B) - thiE gene Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Indicus|evm.model.PRDE01066873.1.1 P59571 COPA_PSESM 52.000 0.419492 0.400679 copA - Copper resistance protein A homolog precursor - Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) - copA gene Could be involved in copper resistance. May have oxidase activity (By similarity). Indicus|evm.model.PRDE01066921.1.1 C1B1E2 SECA_RHOOB 77.500 0.991667 0.125654 secA - Protein translocase subunit SecA - Rhodococcus opacus (strain B4) - secA gene Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Indicus|evm.model.PRDE01066954.1.1 A9AGZ3 NDK_BURM1 87.500 0.975309 0.574468 ndk - Nucleoside diphosphate kinase - Burkholderia multivorans (strain ATCC 17616 / 249) - ndk gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Indicus|evm.model.PRDE01066995.1.1 P28725 FKBP_STRAQ 69.811 0.944444 0.435484 fkbP - FK506-binding protein - Streptomyces anulatus - fkbP gene PPIases accelerate the folding of proteins. Indicus|evm.model.PRDE01067147.1.1 O60524 NEMF_HUMAN 67.500 0.214286 0.169145 NEMF - Nuclear export mediator factor NEMF - Homo sapiens (Human) - NEMF gene Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875). Indicus|evm.model.PRDE01067152.1.1 Q92GF9 AK_RICCN 51.923 0.649351 0.38404 lysC - Aspartokinase - Rickettsia conorii (strain ATCC VR-613 / Malish 7) - lysC gene Indicus|evm.model.PRDE01067246.1.1 C1A1L0 ECTC_RHOE4 71.538 0.620192 1.57576 ectC - L-ectoine synthase - Rhodococcus erythropolis (strain PR4 / NBRC 100887) - ectC gene Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant. Indicus|evm.model.PRDE01067329.1.1 Q93RW2 ECTA_STRCO 53.289 0.831461 1.04706 ectA - L-2,4-diaminobutyric acid acetyltransferase - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - ectA gene Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. Indicus|evm.model.PRDE01067428.1.1 P9WMI5 SMTB_MYCTU 60.000 0.865079 0.933333 smtB - HTH-type transcriptional repressor SmtB - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - smtB gene Transcriptional regulator involved in zinc homeostasis. Represses the expression of the smtB-zur operon in the absence of zinc. Could act as the metal sensor that controls the expression of zur in response to zinc availability. Indicus|evm.model.PRDE01067502.1.1 P29934 COBT_SINSX 41.026 0.963636 0.174326 cobT - Aerobic cobaltochelatase subunit CobT - Sinorhizobium sp. - cobT gene Catalyzes cobalt insertion in the corrin ring. Indicus|evm.model.PRDE01067693.1.1 A0PP48 UVRB_MYCUA 86.331 0.811765 0.242511 uvrB - UvrABC system protein B - Mycobacterium ulcerans (strain Agy99) - uvrB gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage. Indicus|evm.model.PRDE01067808.1.1 A4YI89 HPCD_METS5 46.875 0.658333 0.926641 Msed_2001 - 3-hydroxypropionyl-coenzyme A dehydratase - Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) - Msed_2001 gene Plays a role in autotrophic carbon fixation via the 3-hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl-CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crotonyl-CoA. Inactive towards (R)-3-hydroxybutyryl-CoA. Indicus|evm.model.PRDE01067880.1.1 Q9LFH5 RL122_ARATH 65.101 0.993243 0.891566 RPL12B - 60S ribosomal protein L12-2 - Arabidopsis thaliana (Mouse-ear cress) - RPL12B gene Binds directly to 26S ribosomal RNA. Indicus|evm.model.PRDE01067911.1.1 O30085 COPB_ARCFU 62.264 0.897727 0.255072 copB - Copper-exporting P-type ATPase B - Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) - copB gene Involved in copper export. Indicus|evm.model.PRDE01067946.1.1 P58333 TKT_RHIME 67.769 0.774194 0.223343 cbbT - Transketolase - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - cbbT gene Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Indicus|evm.model.PRDE01068088.1.1 P9WFP5 Y1462_MYCTU 60.403 0.993289 0.375315 Rv1462 - UPF0051 protein Rv1462 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1462 gene response to host immune response Indicus|evm.model.PRDE01068097.1.1 Q9X2M2 BETA_STAXY 68.531 0.979021 0.255357 betA - Oxygen-dependent choline dehydrogenase - Staphylococcus xylosus - betA gene Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. Indicus|evm.model.PRDE01068181.1.2 B4RCC6 RL19_PHEZH 86.957 0.938144 0.729323 rplS - 50S ribosomal protein L19 - Phenylobacterium zucineum (strain HLK1) - rplS gene This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. Indicus|evm.model.PRDE01068322.1.1 Q5B1Q2 ATM1_EMENI 50.000 0.585938 0.177531 atm1 - Iron-sulfur clusters transporter atm1, mitochondrial precursor - Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) - atm1 gene Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by nfs1 and other mitochondrial proteins (By similarity). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity). Indicus|evm.model.PRDE01068406.1.1 Q70LM5 LGRC_BREPA 46.610 0.965217 0.0148272 lgrC - Linear gramicidin synthase subunit C - Brevibacillus parabrevis - lgrC gene Activates the 7th to 12th amino acids (Val, D-Val, Trp, D-Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 8th (D-Val), the 10th (D-Leu) and 12th (D-Leu) amino acids. The 11th (Xaa) amino acid is Trp in linear gramicidin A; Phe in linear gramicidin B and Tyr in linear gramicidin C. Indicus|evm.model.PRDE01068481.1.1 Q8YIG1 KPRS_BRUME 84.783 0.737705 0.196774 prs - Ribose-phosphate pyrophosphokinase - Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) - prs gene Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). Indicus|evm.model.PRDE01068490.1.1 Q7UXK9 DNAE2_RHOBA 72.381 0.990476 0.0917031 dnaE2 - Error-prone DNA polymerase - Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1) - dnaE2 gene DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. Indicus|evm.model.PRDE01068732.1.1 O53182 KORA_MYCTU 55.660 0.990566 0.162328 korA - 2-oxoglutarate oxidoreductase subunit KorA - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - korA gene Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha-ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitro; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M.tuberculosis during infection, flux through KOR likely represents an important step in intermediary metabolism in vivo. KOR-dependent decarboxylation of KG also appears to be an important source of CO(2) in M.tuberculosis metabolism. Indicus|evm.model.PRDE01068812.1.1 P9WNT7 DPO3A_MYCTU 54.545 0.9801 0.169764 dnaE1 - DNA polymerase III subunit alpha - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - dnaE1 gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity). Indicus|evm.model.PRDE01068820.1.1 Q1B6R2 LIPB_MYCSS 74.627 0.985185 0.567227 lipB - Octanoyltransferase - Mycobacterium sp. (strain MCS) - lipB gene Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Indicus|evm.model.PRDE01068977.1.1 Q6VY07 PACS1_HUMAN 100.000 0.952381 0.0436137 PACS1 - Phosphofurin acidic cluster sorting protein 1 - Homo sapiens (Human) - PACS1 gene Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Indicus|evm.model.PRDE01069010.1.1 P0C7X4 FHL19_HUMAN 59.740 0.974359 0.38806 FTH1P19 - Putative ferritin heavy polypeptide-like 19 - Homo sapiens (Human) - FTH1P19 gene cytoplasm, ferric iron binding, ferrous iron binding, ferroxidase activity, intracellular sequestering of iron ion Indicus|evm.model.PRDE01069218.1.1 B1MBV2 TRPA_MYCA9 66.860 0.994186 0.656489 trpA - Tryptophan synthase alpha chain - Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) - trpA gene The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Indicus|evm.model.PRDE01069242.1.1 P46139 DGCN_ECOLI 43.243 0.464968 0.384804 dgcN - Diguanylate cyclase DgcN - Escherichia coli (strain K12) - dgcN gene Bifunctional protein that catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) in response to reductive stress and then dynamically relocates to the division site to arrest cell division in response to envelope stress. In the presence of high intracellular c-di-GMP levels, and in response to envelope stress, interacts with cell division proteins and halts cell division, without disassembling the Z ring, but by blocking its further progress toward cytokinesis (PubMed:27507823). Part of a network that regulates cell motility by altering levels of c-di-GMP (PubMed:20303158). Indicus|evm.model.PRDE01069355.1.1 Q80T03 MUC6_MOUSE 78.906 0.933824 0.0477193 Muc6 - Mucin-6 precursor - Mus musculus (Mouse) - Muc6 gene May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Indicus|evm.model.PRDE01069367.1.1 P10125 UVRB_MICLC 80.226 0.99375 0.22567 uvrB - UvrABC system protein B - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - uvrB gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage. Indicus|evm.model.PRDE01069368.1.1 Q50186 FTSWL_MYCLE 61.000 0.934272 0.458065 rodA - Peptidoglycan glycosyltransferase RodA - Mycobacterium leprae (strain TN) - rodA gene Transglycosylase involved in peptidoglycan cell wall formation. Required for the regulation of cell length. Indicus|evm.model.PRDE01069369.1.1 A0R611 AFTA_MYCS2 59.615 0.432203 0.189103 aftA - Galactan 5-O-arabinofuranosyltransferase - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - aftA gene Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf. Indicus|evm.model.PRDE01069375.1.1 Q5YPE0 RPOB2_NOCFA 79.213 0.994382 0.153052 rpoB2 - DNA-directed RNA polymerase subunit beta 2 - Nocardia farcinica (strain IFM 10152) - rpoB2 gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01069391.1.1 Q0NXR6 ACAD8_BOVIN 51.587 0.968992 0.310096 ACAD8 - Isobutyryl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACAD8 gene Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA. Indicus|evm.model.PRDE01069453.1.1 Q8P3E3 PLSB_XANCP 77.580 0.955631 0.3307 plsB - Glycerol-3-phosphate acyltransferase - Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) - plsB gene plasma membrane, glycerol-3-phosphate O-acyltransferase activity, fatty acid metabolic process, glycerol-3-phosphate metabolic process, phospholipid biosynthetic process, triglyceride biosynthetic process Indicus|evm.model.PRDE01069834.1.1 Q47TY2 RECR_THEFY 88.525 0.869565 0.346734 recR - Recombination protein RecR - Thermobifida fusca (strain YX) - recR gene May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. Indicus|evm.model.PRDE01069844.1.1 P28339 DPOD1_BOVIN 98.571 0.932432 0.0669078 POLD1 - DNA polymerase delta catalytic subunit - Bos taurus (Bovine) - POLD1 gene As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites. Indicus|evm.model.PRDE01070251.1.1 Q52328 KLAB_ECOLX 59.130 0.883721 0.34127 klaB - Protein KlaB - Escherichia coli - klaB gene Belongs to the kla operon, which is associated with cryptic tellurite resistance, and IncW plasmid fertility inhibition. Indicus|evm.model.PRDE01070561.1.1 A4FBF8 NUSB_SACEN 56.589 0.905797 0.932432 nusB - Transcription antitermination protein NusB - Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) - nusB gene Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. Indicus|evm.model.PRDE01070799.1.1 P94400 YCIC_BACSU 61.006 0.993671 0.397985 yciC - Putative metal chaperone YciC - Bacillus subtilis (strain 168) - yciC gene May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc. Indicus|evm.model.PRDE01070897.1.1 P77935 PUR1_RHIEC 54.783 0.991304 0.231855 purF - Amidophosphoribosyltransferase precursor - Rhizobium etli (strain CFN 42 / ATCC 51251) - purF gene Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. Indicus|evm.model.PRDE01071549.1.1 Q4UJM1 SDHA_RICFE 61.290 0.958333 0.161074 sdhA - Succinate dehydrogenase flavoprotein subunit - Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) - sdhA gene Indicus|evm.model.PRDE01071721.1.1 Q1XDB2 GLTB_PYRYE 47.170 0.681818 0.10013 gltB - Ferredoxin-dependent glutamate synthase - Pyropia yezoensis (Susabi-nori) - gltB gene Indicus|evm.model.PRDE01071732.1.1 P35819 PILQ_NEIGO 56.410 0.59375 0.0888889 pilQ - Type IV pilus biogenesis and competence protein PilQ precursor - Neisseria gonorrhoeae - pilQ gene Required for type IV pilus biogenesis and competence. Could function as a pore for exit of the pilus but also as a channel for entry of heme and antimicrobial agents and uptake of transforming DNA. Indicus|evm.model.PRDE01072095.1.1 Q5ZWR1 COPA_LEGPH 58.741 0.972603 0.19837 copA - Copper-exporting P-type ATPase - Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) - copA gene Couples the hydrolysis of ATP with the export of copper. Indicus|evm.model.PRDE01072209.1.1 P9WQ65 AMT_MYCTU 49.102 0.986667 0.314465 amt - Ammonium transporter - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - amt gene Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)). Indicus|evm.model.PRDE01072380.1.1 P9WMR5 DING_MYCTU 81.538 0.761905 0.126506 dinG - Probable ATP-dependent helicase DinG homolog - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - dinG gene Probable helicase involved in DNA repair and perhaps also replication. Indicus|evm.model.PRDE01072415.1.1 Q45979 Y952_CAUVC 53.659 0.870968 0.877358 CC_0952 - Uncharacterized protein CC_0952 - Caulobacter vibrioides (strain ATCC 19089 / CB15) - CC_0952 gene Indicus|evm.model.PRDE01072488.1.1 A0R6H7 IRTB_MYCS2 59.504 0.991736 0.210069 irtB - Mycobactin import ATP-binding/permease protein IrtB - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - irtB gene Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:32296173). Has a preference for Fe-MBT over Fe-cMBT (PubMed:32296173). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (PubMed:32296173). Indicus|evm.model.PRDE01072509.1.1 A8F109 MURB_RICM5 66.667 0.805085 0.4 murB - UDP-N-acetylenolpyruvoylglucosamine reductase - Rickettsia massiliae (strain Mtu5) - murB gene Cell wall formation. Indicus|evm.model.PRDE01072596.1.1 I3R7F1 PCCB_HALMT 55.294 0.976744 0.166667 pccB - Propionyl-CoA carboxylase, carboxyltransferase subunit - Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) - pccB gene Part of the propionyl coenzyme A carboxylase (PCC) complex involved in propionate utilization and in the production of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV), which is a water-insoluble biopolymer used as intracellular energy reserve material when cells grow under conditions of nutrient limitation. The complex catalyzes the carboxylation of propionyl-CoA to methylmalonyl-CoA. PCC is also able to catalyze the carboxylation of acetyl-CoA. Indicus|evm.model.PRDE01072730.1.1 Q50308 RL14_MYCPN 66.102 0.89313 1.07377 rplN - 50S ribosomal protein L14 - Mycoplasma pneumoniae (strain ATCC 29342 / M129) - rplN gene Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome. Indicus|evm.model.PRDE01072805.1.1 Q2YQA5 CHPT_BRUA2 48.980 0.716418 0.320574 chpT - Protein phosphotransferase ChpT - Brucella abortus (strain 2308) - chpT gene Component of a regulatory phosphorelay system that controls B.abortus cell growth, division, and intracellular survival inside mammalian host cells. This signaling pathway is composed of CckA, ChpT, CtrA and CpdR. ChpT efficiently and specifically shuttles phosphoryl groups from the CckA kinase to the receiver domains of both CtrA and CpdR. Does not bind ATP. Overexpression of chpT results in a defect in cell morphology, DNA content, and intracellular survival in human macrophages. Indicus|evm.model.PRDE01072830.1.1 Q57074 ISCU_HAEIN 82.258 0.891304 1.09524 iscU - Iron-sulfur cluster assembly scaffold protein IscU - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - iscU gene A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity). Indicus|evm.model.PRDE01072837.1.1 C0ZVP8 RL34_RHOE4 89.362 0.380165 2.57447 rpmH - 50S ribosomal protein L34 - Rhodococcus erythropolis (strain PR4 / NBRC 100887) - rpmH gene Indicus|evm.model.PRDE01072878.1.1 O34984 YODQ_BACSU 46.552 0.414815 0.309633 yodQ - Uncharacterized metallohydrolase YodQ - Bacillus subtilis (strain 168) - yodQ gene Indicus|evm.model.PRDE01072892.1.1 Q94AM1 OOPDA_ARATH 51.724 0.759259 0.136536 OOP - Organellar oligopeptidase A, chloroplastic/mitochondrial precursor - Arabidopsis thaliana (Mouse-ear cress) - OOP gene Oligopeptidase degrading short peptides from 8 to 23 amino acid residues. Plays a role in the degradation of transit peptides and of peptides derived from other proteolytic events. Does not exhibit a strict cleavage pattern. Binds salicylic acid. Indicus|evm.model.PRDE01072964.1.1 C7MC16 FTSH_BRAFD 82.209 0.925714 0.24858 ftsH - ATP-dependent zinc metalloprotease FtsH - Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / JCM 11609 / LMG 19847 / NBRC 14762 / NCIMB 9860 / 6-10) - ftsH gene Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Indicus|evm.model.PRDE01073116.1.1 Q04954 FLIF_CAUVC 50.303 0.987879 0.307836 fliF - Flagellar M-ring protein - Caulobacter vibrioides (strain ATCC 19089 / CB15) - fliF gene The M ring may be actively involved in energy transduction. Indicus|evm.model.PRDE01073240.1.1 P63696 Y941_MYCBO 50.000 0.910377 0.357504 BQ2027_MB0941 - Uncharacterized transporter Mb0941 - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - BQ2027_MB0941 gene Indicus|evm.model.PRDE01073241.1.1 Q6FDF6 BETT1_ACIAD 48.485 0.613208 0.201521 betT1 - Osmo-independent choline transporter BetT1 - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - betT1 gene Sodium-independent high-affinity choline uptake system. Uptake is not proton coupled. May play a role in metabolic adaptation to choline-containing environments. Indicus|evm.model.PRDE01073524.1.1 B5ZRD7 CH10_RHILW 89.691 0.969697 1.0102 groS - 10 kDa chaperonin - Rhizobium leguminosarum bv. trifolii (strain WSM2304) - groS gene Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. Indicus|evm.model.PRDE01073569.1.1 Q8CJM2 PGLX_STRCO 48.485 0.644737 0.12562 pglX - Adenine-specific methyltransferase PglX - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - pglX gene BREX systems (bacteriophage exclusion) provide immunity against bacteriophage. Part of a type 2 BREX system (Probable). Probably a DNA methyltransferase, it methylates phage DNA in vitro in an S-adenosyl-L-methionine-dependent manner (PubMed:25592393). Previously called the phage growth limitation (Pgl) system, it confers protection against bacteriophage phiC31. The bacteria allows one cycle of phage infection, but subsequent cycles are impaired, protecting the original bacterial colony (Probable). The system undergoes high rates (10(-3) to 10(-4)) of phase reversion, i.e. loss and regain of phiC31 resistance (PubMed:8446035, PubMed:12867465). When the pglW-pglX-pglY-pglZ genes are transformed into a susceptible S.lividans (strain 1326) they confer resistance to infection by phage phiC31 and phiBT1; all 4 genes are necessary (PubMed:11972785). Indicus|evm.model.PRDE01073642.1.1 Q7VYS4 Y1235_BORPE 58.000 0.678082 0.648889 BP1235 - UPF0758 protein BP1235 - Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) - BP1235 gene Indicus|evm.model.PRDE01073773.1.1 A3MZR0 ERA_ACTP2 53.252 0.987854 0.8125 era - GTPase Era - Actinobacillus pleuropneumoniae serotype 5b (strain L20) - era gene An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. Indicus|evm.model.PRDE01073855.1.1 Q47H39 KDPB_DECAR 78.400 0.984127 0.18314 kdpB - Potassium-transporting ATPase ATP-binding subunit - Dechloromonas aromatica (strain RCB) - kdpB gene Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01073970.1.1 Q6FG19 RECF_ACIAD 83.594 0.954887 0.371508 recF - DNA replication and repair protein RecF - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - recF gene The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. Indicus|evm.model.PRDE01073994.1.1 P0ABH9 CLPA_ECOLI 69.231 0.984733 0.172823 clpA - ATP-dependent Clp protease ATP-binding subunit ClpA - Escherichia coli (strain K12) - clpA gene ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins. Indicus|evm.model.PRDE01074049.1.1 O52529 FLJM_CAUVC 60.989 0.989071 0.67033 fljM - Flagellin FljM - Caulobacter vibrioides (strain ATCC 19089 / CB15) - fljM gene Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Indicus|evm.model.PRDE01074180.1.1 A5FGV5 DEF_FLAJ1 63.478 0.99115 0.576531 def - Peptide deformylase - Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101) - def gene Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. Indicus|evm.model.PRDE01074191.1.1 P77788 NUDG_ECOLI 58.929 0.381944 1.06667 nudG - CTP pyrophosphohydrolase - Escherichia coli (strain K12) - nudG gene Hydrolase with a preference for pyrimidine substrates. Has high activity with 5-methyl-dCTP, and much lower activity with CTP, dCTP, 5-hydroxy-dCTP, 2-hydroxy-dATP and 8-hydroxy-dGTP. Indicus|evm.model.PRDE01074255.1.1 Q8A1G1 SUSC_BACTN 47.253 0.739496 0.118644 susC - TonB-dependent receptor SusC precursor - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - susC gene Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation. Indicus|evm.model.PRDE01074260.1.1 Q11Q97 SYN_CYTH3 74.713 0.977273 0.189655 asnS - Asparagine--tRNA ligase - Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465) - asnS gene Indicus|evm.model.PRDE01074271.1.1 Q79VI4 METY_CORGL 66.142 0.65285 0.441648 metY - O-acetyl-L-homoserine sulfhydrylase - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - metY gene Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway (PubMed:11844756, Ref.4, PubMed:18050920). Can also use dimethyldisulfide and methanethiol as reduced sulfur sources, leading to the direct formation of methionine (PubMed:20798582). Has weak cystathionine gamma-synthase activity (PubMed:18050920). Indicus|evm.model.PRDE01074287.1.1 Q5YPC7 RL10_NOCFA 68.605 0.988372 0.488636 rplJ - 50S ribosomal protein L10 - Nocardia farcinica (strain IFM 10152) - rplJ gene Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Indicus|evm.model.PRDE01074337.1.1 B0VDG6 RL11_ACIBY 99.296 0.986014 1.00704 rplK - 50S ribosomal protein L11 - Acinetobacter baumannii (strain AYE) - rplK gene Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Indicus|evm.model.PRDE01074339.1.1 A9VY49 SYS_METEP 76.159 0.986755 0.352804 serS - Serine--tRNA ligase - Methylorubrum extorquens (strain PA1) - serS gene Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). Indicus|evm.model.PRDE01074412.1.1 Q5C9I9 ISPD_MENPI 46.667 0.973333 0.283019 (-)-isopiperitenol/(-)-carveol dehydrogenase, mitochondrial precursor - Mentha piperita (Peppermint) Indicus|evm.model.PRDE01074659.1.1 Q2W0M1 UVRC_MAGSA 69.672 0.991736 0.19391 uvrC - UvrABC system protein C - Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) - uvrC gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. Indicus|evm.model.PRDE01074721.1.1 P14218 DLDH_PSEFL 65.455 0.939655 0.242678 lpd - Dihydrolipoyl dehydrogenase - Pseudomonas fluorescens - lpd gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Indicus|evm.model.PRDE01074854.1.1 P43501 PILH_PSEAE 67.000 0.970588 0.842975 pilH - Protein PilH - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pilH gene May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). Indicus|evm.model.PRDE01074894.1.1 Q3IG30 Y2554_PSET1 76.068 0.928 0.44484 PSHAa2554 - Nucleotide-binding protein PSHAa2554 - Pseudoalteromonas translucida (strain TAC 125) - PSHAa2554 gene Displays ATPase and GTPase activities. Indicus|evm.model.PRDE01074932.1.1 P77726 YAJR_ECOLI 45.631 0.926606 0.240088 yajR - Inner membrane transport protein YajR - Escherichia coli (strain K12) - yajR gene integral component of plasma membrane, transmembrane transport Indicus|evm.model.PRDE01075132.1.1 B4ETK7 IF3_PROMH 77.679 0.982301 0.631285 infC - Translation initiation factor IF-3 - Proteus mirabilis (strain HI4320) - infC gene IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. Indicus|evm.model.PRDE01075141.1.1 Q83RR8 NPD_SHIFL 56.923 0.977273 0.483516 cobB - NAD-dependent protein deacylase - Shigella flexneri - cobB gene NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Indicus|evm.model.PRDE01075208.1.1 B8GZM2 PLED_CAUVN 44.355 0.97619 0.277533 pleD - Response regulator PleD - Caulobacter vibrioides (strain NA1000 / CB15N) - pleD gene Response regulator that is part of a signal transduction pathway controlling cell differentiation in the swarmer-to-stalked cell transition. Indicus|evm.model.PRDE01075345.1.1 Q9QZ23 NFU1_MOUSE 48.649 0.701923 0.407843 Nfu1 - NFU1 iron-sulfur cluster scaffold homolog, mitochondrial precursor - Mus musculus (Mouse) - Nfu1 gene Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins. Indicus|evm.model.PRDE01075394.1.1 P08201 NIRB_ECOLI 61.000 0.876106 0.133412 nirB - Nitrite reductase (NADH) large subunit - Escherichia coli (strain K12) - nirB gene nitrite reductase complex [NAD(P)H], flavin adenine dinucleotide binding, heme binding, iron-sulfur cluster binding, NADP binding, nitrite reductase [NAD(P)H] activity, anaerobic respiration Indicus|evm.model.PRDE01075419.1.1 B3PK31 RPOC_CELJU 87.943 0.979021 0.101635 rpoC - DNA-directed RNA polymerase subunit beta' - Cellvibrio japonicus (strain Ueda107) - rpoC gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01075585.1.1 P50848 CBP1_BACSU 47.826 0.80531 0.225549 ypwA - Carboxypeptidase 1 - Bacillus subtilis (strain 168) - ypwA gene Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. Has lower activity with substrates ending with His or Trp. Indicus|evm.model.PRDE01075639.1.1 A1B8C4 MIAB_PARDP 86.111 0.993056 0.323596 miaB - tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase - Paracoccus denitrificans (strain Pd 1222) - miaB gene Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. Indicus|evm.model.PRDE01075701.1.1 Q83BS0 NUSA_COXBU 51.333 0.993243 0.294235 nusA - Transcription termination/antitermination protein NusA - Coxiella burnetii (strain RSA 493 / Nine Mile phase I) - nusA gene Participates in both transcription termination and antitermination. Indicus|evm.model.PRDE01075838.1.1 Q9HVZ3 RSMI_PSEAE 54.500 0.956098 0.72695 rsmI - Ribosomal RNA small subunit methyltransferase I - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - rsmI gene Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. Indicus|evm.model.PRDE01075840.1.1 Q52981 PHAD_RHIME 57.317 0.987879 0.306122 phaD - Probable K(+)/H(+) antiporter subunit D - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - phaD gene Part of a K(+) efflux system which is required for the adaptation of R.meliloti to alkaline pH as well as for the infection process during symbiotic nodule development. Indicus|evm.model.PRDE01075849.1.1 Q1RI82 MFD_RICBR 54.610 0.939597 0.133036 mfd - Transcription-repair-coupling factor - Rickettsia bellii (strain RML369-C) - mfd gene Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site. Indicus|evm.model.PRDE01075858.1.1 Q6FG02 SYI_ACIAD 73.988 0.988506 0.184127 ileS - Isoleucine--tRNA ligase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - ileS gene Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Indicus|evm.model.PRDE01076105.1.1 B0VSL8 GREA_ACIBS 87.671 0.91195 1.00633 greA - Transcription elongation factor GreA - Acinetobacter baumannii (strain SDF) - greA gene Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. Indicus|evm.model.PRDE01076120.1.1 P26275 ALGR_PSEAE 47.390 0.991903 0.995968 algR - Positive alginate biosynthesis regulatory protein - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - algR gene Positive regulator of the algD gene, which codes for a GDP-mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway. Indicus|evm.model.PRDE01076135.1.1 P41077 PNTAA_RICPR 61.905 0.94697 0.344648 pntAA - NAD(P) transhydrogenase subunit alpha part 1 - Rickettsia prowazekii (strain Madrid E) - pntAA gene The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. Indicus|evm.model.PRDE01076153.1.1 Q48815 HELA_LEGPN 57.065 0.994565 0.174905 helA - Protein HelA - Legionella pneumophila - helA gene Presumed to function with HelC and HelB in efflux of an unidentified substrate. Indicus|evm.model.PRDE01076200.1.1 P54925 DEGPL_BARHE 65.546 0.951613 0.246521 htrA - Probable periplasmic serine endoprotease DegP-like precursor - Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) - htrA gene Could be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. Indicus|evm.model.PRDE01076215.1.1 B7J950 ARREH_ACIF2 85.000 0.983333 0.253165 arsH - NADPH-dependent FMN reductase ArsH - Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455) - arsH gene Has NADPH-dependent FMN reductase activity and high NADPH-dependent ferric reductase activity with highest activity for Fe(3+) as substrate. No activity with NADH, iron trichloride, Cu(2+) or Ag(+). May be involved in cytosolic ferric iron assimilation as an NADPH-dependent ferric reductase in vivo. Indicus|evm.model.PRDE01076405.1.1 Q0VM78 SECB_ALCBS 69.159 0.990476 0.66879 secB - Protein-export protein SecB - Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2) - secB gene One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. Indicus|evm.model.PRDE01076434.1.1 D4GPW3 TSGDD_HALVD 51.136 0.851485 0.183636 tsgD13 - Glucose import ATP-binding protein TsgD13 - Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) - tsgD13 gene Part of an ABC transporter complex involved in glucose import (Probable). Responsible for energy coupling to the transport system (By similarity). Indicus|evm.model.PRDE01076507.1.1 P0AB80 ILVE_ECOLI 70.139 0.993056 0.466019 ilvE - Branched-chain-amino-acid aminotransferase - Escherichia coli (strain K12) - ilvE gene Acts on leucine, isoleucine and valine. Indicus|evm.model.PRDE01076564.1.1 Q73TT7 ILVD_MYCPA 56.140 0.904 0.217391 ilvD - Dihydroxy-acid dehydratase - Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) - ilvD gene Indicus|evm.model.PRDE01076599.1.1 P46562 AL7A1_CAEEL 56.522 0.991304 0.216573 alh-9 - Putative aldehyde dehydrogenase family 7 member A1 homolog - Caenorhabditis elegans - alh-9 gene aldehyde dehydrogenase (NAD+) activity, cellular aldehyde metabolic process Indicus|evm.model.PRDE01076606.1.1 P22106 ASNB_ECOLI 67.429 0.994286 0.315884 asnB - Asparagine synthetase B [glutamine-hydrolyzing] - Escherichia coli (strain K12) - asnB gene Catalyzes the ATP-dependent conversion of aspartate into asparagine, using glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro, albeit with lower efficiency. As nucleotide substrates, ATP and dATP are utilized at a similar rate in both the glutamine- and ammonia-dependent reactions, whereas GTP utilization is only 15% that of ATP, and CTP, UTP, ITP and XTP are very poor or not substrates. Also exhibits glutaminase activity. Indicus|evm.model.PRDE01076665.1.1 B8GW43 NDK_CAUVN 89.928 0.985714 1.00719 ndk - Nucleoside diphosphate kinase - Caulobacter vibrioides (strain NA1000 / CB15N) - ndk gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Indicus|evm.model.PRDE01076687.1.1 Q7PYQ5 FAM50_ANOGA 83.893 0.972028 0.399441 AGAP002062 - Protein FAM50 homolog - Anopheles gambiae (African malaria mosquito) - AGAP002062 gene nucleus, chromatin organization Indicus|evm.model.PRDE01076798.1.1 Q48815 HELA_LEGPN 69.481 0.980263 0.144487 helA - Protein HelA - Legionella pneumophila - helA gene Presumed to function with HelC and HelB in efflux of an unidentified substrate. Indicus|evm.model.PRDE01076828.1.1 P14218 DLDH_PSEFL 59.589 0.993151 0.305439 lpd - Dihydrolipoyl dehydrogenase - Pseudomonas fluorescens - lpd gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Indicus|evm.model.PRDE01076850.1.1 Q9KUW5 UVRA_VIBCH 79.787 0.979058 0.203191 uvrA - UvrABC system protein A - Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) - uvrA gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Indicus|evm.model.PRDE01076871.1.1 Q02006 Y4233_RHOPA 46.429 0.714286 0.186893 RPA4233 - Putative potassium channel protein RPA4233 - Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) - RPA4233 gene Indicus|evm.model.PRDE01077016.1.1 P46394 DNAB_MYCLE 67.778 0.988889 0.149007 dnaB - Replicative DNA helicase - Mycobacterium leprae (strain TN) - dnaB gene Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Indicus|evm.model.PRDE01077089.1.1 Q51567 SUCD_PSEAE 74.490 0.881818 0.372881 sucD - Succinate--CoA ligase [ADP-forming] subunit alpha - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - sucD gene Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. Can also generate UTP or CTP, although it preferentially synthesizes ATP and/or GTP. Indicus|evm.model.PRDE01077178.1.1 O34863 UVRA_BACSU 56.911 0.99187 0.128527 uvrA - UvrABC system protein A - Bacillus subtilis (strain 168) - uvrA gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Indicus|evm.model.PRDE01077193.1.1 O53732 UFAA1_MYCTU 56.452 0.769231 0.18267 ufaA1 - Tuberculostearic acid methyltransferase UfaA1 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - ufaA1 gene Involved in the biosynthesis of the tuberculostearic acid (10-methylstearic-acid or TSA), a constituent lipid of the mycobacterial cell wall. Catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (SAM) to the double bond of oleic acid in phosphatidylethanolamine or phosphatidylcholine to produce TSA. Indicus|evm.model.PRDE01077304.1.1 Q5F3T7 CELF1_CHICK 50.877 0.965517 0.118609 CELF1 - CUGBP Elav-like family member 1 - Gallus gallus (Chicken) - CELF1 gene RNA-binding protein that may be involved in pre-mRNA alternative splicing, mRNA translation activation and stability. Indicus|evm.model.PRDE01077307.1.1 P76558 MAO2_ECOLI 60.227 0.925532 0.123847 maeB - NADP-dependent malic enzyme - Escherichia coli (strain K12) - maeB gene cytosol, malate dehydrogenase (decarboxylating) (NADP+) activity, manganese ion binding Indicus|evm.model.PRDE01077361.1.1 Q5SJ35 KT3K_THET8 43.210 0.810526 0.362595 TTHA1179 - Probable ketoamine kinase TTHA1179 - Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) - TTHA1179 gene Ketoamine kinase that phosphorylates ketoamines, such as erythruloselysine and ribuloselysine, on the third carbon of the sugar moiety to generate ketoamine 3-phosphate (PubMed:17681011). Has higher activity on free lysine (erythruloselysine and ribuloselysine), than on ribuloselysine and erythruloselysine residues on glycated proteins (PubMed:17681011). Indicus|evm.model.PRDE01077433.1.1 Q6AFZ2 SYV_LEIXX 63.576 0.825581 0.199536 valS - Valine--tRNA ligase - Leifsonia xyli subsp. xyli (strain CTCB07) - valS gene Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner. Indicus|evm.model.PRDE01077439.1.1 Q72ET7 HLDD_DESVH 54.887 0.970588 0.421053 hldD - ADP-L-glycero-D-manno-heptose-6-epimerase - Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) - hldD gene Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. Indicus|evm.model.PRDE01077506.1.2 B4SNL7 HEM6_STRM5 88.679 0.981132 0.177852 hemF - Oxygen-dependent coproporphyrinogen-III oxidase - Stenotrophomonas maltophilia (strain R551-3) - hemF gene Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. Indicus|evm.model.PRDE01077631.1.1 B6UI56 OBP2B_MAIZE 45.794 0.87395 0.476 OBAP2B - Oil body-associated protein 2B - Zea mays (Maize) - OBAP2B gene Indicus|evm.model.PRDE01077852.1.1 A0A385XJE6 INH21_ECOLI 51.145 0.969925 0.407975 insH21 - Transposase InsH for insertion sequence element IS5U - Escherichia coli (strain K12) - insH21 gene Involved in the transposition of the insertion sequence IS5. Indicus|evm.model.PRDE01078073.1.1 P37557 YABO_BACSU 48.333 0.42446 1.61628 yabO - Uncharacterized protein YabO - Bacillus subtilis (strain 168) - yabO gene Indicus|evm.model.PRDE01078105.1.1 A4IL76 CLS_GEOTN 53.636 0.931624 0.233068 cls - Cardiolipin synthase - Geobacillus thermodenitrificans (strain NG80-2) - cls gene Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Indicus|evm.model.PRDE01078132.1.1 Q9A655 APAG_CAUVC 72.277 0.980392 0.728571 apaG - Protein ApaG - Caulobacter vibrioides (strain ATCC 19089 / CB15) - apaG gene Indicus|evm.model.PRDE01078268.1.1 C5C9D1 GLMU_MICLC 64.706 0.990099 0.203219 glmU - Bifunctional protein GlmU - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - glmU gene Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. Indicus|evm.model.PRDE01078436.1.1 A4TRH7 CAPP_YERPP 59.829 0.982759 0.132118 ppc - Phosphoenolpyruvate carboxylase - Yersinia pestis (strain Pestoides F) - ppc gene Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Indicus|evm.model.PRDE01078462.1.1 P00234 FER1_EQUTE 46.591 0.68 1.31579 Ferredoxin-1 - Equisetum telmateia (Great horsetail) Indicus|evm.model.PRDE01078659.1.1 B4EY89 PUR5_PROMH 72.973 0.990991 0.320809 purM - Phosphoribosylformylglycinamidine cyclo-ligase - Proteus mirabilis (strain HI4320) - purM gene Indicus|evm.model.PRDE01078692.1.1 B0VQI5 KDSA_ACIBS 95.789 0.989474 0.333333 kdsA - 2-dehydro-3-deoxyphosphooctonate aldolase - Acinetobacter baumannii (strain SDF) - kdsA gene Indicus|evm.model.PRDE01078780.1.1 B8GXQ0 GYRB_CAUVN 78.972 0.995327 0.265839 gyrB - DNA gyrase subunit B - Caulobacter vibrioides (strain NA1000 / CB15N) - gyrB gene A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. Indicus|evm.model.PRDE01078833.1.1 A8GIF8 XNI_SERP5 87.129 0.970874 0.410359 xni - Flap endonuclease Xni - Serratia proteamaculans (strain 568) - xni gene Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Indicus|evm.model.PRDE01079030.1.1 P63389 YHES_ECOLI 54.348 0.866667 0.164835 yheS - Probable ATP-binding protein YheS - Escherichia coli (strain K12) - yheS gene Genetic data indicate it may be involved in ribosome assembly or function. Indicus|evm.model.PRDE01079117.1.1 P77455 PAAZ_ECOLI 54.472 0.930769 0.190896 paaZ - Bifunctional protein PaaZ - Escherichia coli (strain K12) - paaZ gene Catalyzes the hydrolytic ring cleavage of 2-oxepin-2(3H)-ylideneacetyl-CoA (oxepin-CoA) via the open-chain aldehyde intermediate to yield 3-oxo-5,6-dehydrosuberyl-CoA. The enzyme consists of a C-terminal (R)-specific enoyl-CoA hydratase domain (formerly MaoC) that cleaves the ring and produces the highly reactive 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde and an N-terminal NADP-dependent aldehyde dehydrogenase domain that oxidizes the aldehyde to 3-oxo-5,6-dehydrosuberyl-CoA. Can also use crotonyl-CoA as substrate. Indicus|evm.model.PRDE01079252.1.1 Q9JZN9 Y964_NEIMB 45.588 0.663366 0.133245 NMB0964 - Probable TonB-dependent receptor NMB0964 precursor - Neisseria meningitidis serogroup B (strain MC58) - NMB0964 gene Probable receptor, TonB-dependent. Indicus|evm.model.PRDE01079344.1.1 Q3BNK3 SMG_XANC5 85.714 0.96875 0.407643 smg - Protein Smg homolog - Xanthomonas campestris pv. vesicatoria (strain 85-10) - smg gene Indicus|evm.model.PRDE01079404.1.1 Q6F8Q1 HTPX_ACIAD 93.035 0.990099 0.671096 htpX - Protease HtpX - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - htpX gene Indicus|evm.model.PRDE01079599.1.1 Q6F7C8 SYE_ACIAD 79.259 0.992593 0.268924 gltX - Glutamate--tRNA ligase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - gltX gene Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). Indicus|evm.model.PRDE01079912.1.1 Q9WYC4 Y288_THEMA 47.482 0.951724 0.242475 TM_0288 - Uncharacterized ABC transporter ATP-binding protein TM_0288 - Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) - TM_0288 gene ATPase-coupled transmembrane transporter activity, transmembrane transport Indicus|evm.model.PRDE01079924.1.1 P23315 TRPE_ACICA 77.228 0.99505 0.406439 trpE - Anthranilate synthase component 1 - Acinetobacter calcoaceticus - trpE gene Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity). Indicus|evm.model.PRDE01080134.1.1 P42829 INHA_MYCS2 66.071 0.900826 0.449814 inhA - Enoyl-[acyl-carrier-protein] reductase [NADH] - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - inhA gene Enoyl-ACP reductase of the type II fatty acid syntase (FAS-II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls (PubMed:10708367). Catalyzes the NADH-dependent reduction of the double bond of 2-trans-enoyl-[acyl-carrier protein], an essential step in the fatty acid elongation cycle of the FAS-II pathway (PubMed:10869086, PubMed:10708367). Shows preference for long-chain fatty acyl thioester substrates (>C16), and can also use 2-trans-enoyl-CoAs as alternative substrates (By similarity). The mycobacterial FAS-II system utilizes the products of the FAS-I system as primers to extend fatty acyl chain lengths up to C56, forming the meromycolate chain that serves as the precursor for final mycolic acids (PubMed:10869086, PubMed:10708367). Indicus|evm.model.PRDE01080500.1.1 P16019 HSP70_THEAN 96.129 0.987179 0.241486 TA11610 - Heat shock 70 kDa protein - Theileria annulata - TA11610 gene Indicus|evm.model.PRDE01080609.1.1 A0R2G5 DAPD_MYCS2 58.333 0.886792 0.16879 dapD - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - dapD gene Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. Indicus|evm.model.PRDE01081128.1.1 P77735 YAJO_ECOLI 48.276 0.923077 0.280864 yajO - 1-deoxyxylulose-5-phosphate synthase YajO - Escherichia coli (strain K12) - yajO gene Catalyzes the conversion of ribulose 5-phosphate (Ru5P) to 1-deoxy-D-xylulose 5-phosphate (DXP), providing a direct route from pentoses to terpenes. May play a role in biosynthesis of DXP under conditions of thiamine starvation. Indicus|evm.model.PRDE01081309.1.1 Q9A671 HIS81_CAUVC 52.381 0.992754 0.384401 hisC1 - Histidinol-phosphate aminotransferase 1 - Caulobacter vibrioides (strain ATCC 19089 / CB15) - hisC1 gene Indicus|evm.model.PRDE01081511.1.1 Q3L887 FADE5_MYCS2 72.881 0.991525 0.193126 fadE5 - Broad-specificity linear acyl-CoA dehydrogenase FadE5 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - fadE5 gene Acyl-CoA dehydrogenase that exhibits broad specificity for linear acyl-CoA substrates, with a preference for long-chain substrates. Indicus|evm.model.PRDE01081513.1.1 P50970 DLDH_ZYMMO 59.223 0.943396 0.227468 lpd - Dihydrolipoyl dehydrogenase - Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) - lpd gene Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. Indicus|evm.model.PRDE01082028.1.1 Q56208 MOACB_SYNE7 47.863 0.878788 0.413793 moaCB - Molybdenum cofactor biosynthesis bifunctional protein - Synechococcus elongatus (strain PCC 7942 / FACHB-805) - moaCB gene Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Indicus|evm.model.PRDE01082357.1.1 P18956 GGT_ECOLI 48.361 0.755102 0.253448 ggt - Glutathione hydrolase proenzyme precursor - Escherichia coli (strain K12) - ggt gene Cleaves the gamma-glutamyl bond of periplasmic glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases; it may function in amino acid uptake/salvage, or possibly in peptidoglycan linkage. Catalyzes the hydrolysis and transpeptidation of many gamma-glutamyl compounds (including some D-gamma-glutamyl substrates), with a preference for basic and aromatic amino acids as acceptors (PubMed:2877974). The KM values for gamma-glutamyl acceptors are so high that it has been proposed transpeptidation is not the physiological role in E.coli (PubMed:2877974, PubMed:8104180). Indicus|evm.model.PRDE01082414.1.1 P0C187 PNTAB_RHORU 60.714 0.493976 1.19424 pntAB - NAD(P) transhydrogenase subunit alpha part 2 - Rhodospirillum rubrum - pntAB gene The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. Indicus|evm.model.PRDE01082429.1.1 P16942 T629_SHISO 48.889 0.586667 0.253378 Transposase for insertion sequence element IS629 - Shigella sonnei Indicus|evm.model.PRDE01082512.1.1 O34340 FABF_BACSU 56.962 0.819149 0.227603 fabF - 3-oxoacyl-[acyl-carrier-protein] synthase 2 - Bacillus subtilis (strain 168) - fabF gene Involved in the type II fatty acid elongation cycle (PubMed:11325930). Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:11325930). Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition (By similarity). Indicus|evm.model.PRDE01082597.1.1 Q9A2W1 ATPE_CAUVC 82.353 0.965517 1.01163 atpC - ATP synthase epsilon chain - Caulobacter vibrioides (strain ATCC 19089 / CB15) - atpC gene Produces ATP from ADP in the presence of a proton gradient across the membrane. Indicus|evm.model.PRDE01082660.1.1 Q03638 NADE_RHOCA 48.921 0.978571 0.253623 nadE - Glutamine-dependent NAD(+) synthetase - Rhodobacter capsulatus - nadE gene Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. Indicus|evm.model.PRDE01082702.1.1 Q60759 GCDH_MOUSE 48.026 0.986667 0.342466 Gcdh - Glutaryl-CoA dehydrogenase, mitochondrial precursor - Mus musculus (Mouse) - Gcdh gene Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Indicus|evm.model.PRDE01082919.1.1 C3P5A7 Y1610_BACAA 55.556 0.875 0.629213 BAA_1610 - UPF0302 protein BAA_1610 - Bacillus anthracis (strain A0248) - BAA_1610 gene Indicus|evm.model.PRDE01083092.1.1 A6QQL0 S15A4_BOVIN 98.571 0.985714 0.123675 SLC15A4 - Solute carrier family 15 member 4 - Bos taurus (Bovine) - SLC15A4 gene Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (By similarity). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (By similarity). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation. Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). Indicus|evm.model.PRDE01083170.1.1 O30808 MAO2_RHIME 74.219 0.976562 0.1682 tme - NADP-dependent malic enzyme - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - tme gene Indicus|evm.model.PRDE01083196.1.1 P65173 Y1874_MYCBO 50.000 0.991667 0.250522 guaB1 - Uncharacterized oxidoreductase Mb1874c - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - guaB1 gene Indicus|evm.model.PRDE01083230.1.1 Q6F8Q3 TTCA_ACIAD 95.882 0.994118 0.564784 ttcA - tRNA-cytidine(32) 2-sulfurtransferase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - ttcA gene Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. Indicus|evm.model.PRDE01083273.1.1 P80574 AROF_STRCO 60.331 0.882353 0.302222 aroH - Phospho-2-dehydro-3-deoxyheptonate aldolase - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - aroH gene Indicus|evm.model.PRDE01083310.1.1 Q46845 YGHU_ECOLI 78.846 0.87931 0.201389 yghU - Disulfide-bond oxidoreductase YghU - Escherichia coli (strain K12) - yghU gene Exhibits a robust glutathione (GSH)-dependent disulfide-bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides, such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide, but does not reduce H(2)O(2) or tert-butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate. Indicus|evm.model.PRDE01083334.1.1 P17983 YIA1_RHISP 62.500 0.237805 1.76344 Insertion element ISR1 uncharacterized 11 kDa protein A1 - Rhizobium sp. Indicus|evm.model.PRDE01083628.1.1 C4L534 SYH_EXISA 93.077 0.992308 0.30445 hisS - Histidine--tRNA ligase - Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b) - hisS gene Indicus|evm.model.PRDE01083678.1.1 P0A5J3 MAP1_MYCBO 60.748 0.890756 0.417544 map - Methionine aminopeptidase - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - map gene Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. Indicus|evm.model.PRDE01083976.1.1 Q51487 OPRM_PSEAE 54.264 0.992248 0.265979 oprM - Outer membrane protein OprM precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - oprM gene The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the MexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane. Indicus|evm.model.PRDE01084032.1.1 Q82M93 TAL1_STRAW 65.101 0.993056 0.380952 tal1 - Transaldolase 1 - Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) - tal1 gene Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Indicus|evm.model.PRDE01084477.1.1 P10484 T1M1_ECOLX 45.196 0.985714 0.538462 hsdM - Type I restriction enzyme EcoR124II M protein - Escherichia coli - hsdM gene Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The EcoR124/3 I enzyme recognizes 5'-GAAN(7)RTCG-3'. Indicus|evm.model.PRDE01085054.1.1 Q59189 PARE_BORBU 57.025 0.782895 0.253756 parE - DNA topoisomerase 4 subunit B - Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) - parE gene Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity). Indicus|evm.model.PRDE01085161.1.1 B0V4L7 LEUD_ACIBY 80.095 0.963303 1.01395 leuD - 3-isopropylmalate dehydratase small subunit - Acinetobacter baumannii (strain AYE) - leuD gene Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. Indicus|evm.model.PRDE01085793.1.1 Q8PH65 KGUA_XANAC 74.747 0.960784 0.502463 gmk - Guanylate kinase - Xanthomonas axonopodis pv. citri (strain 306) - gmk gene Essential for recycling GMP and indirectly, cGMP. Indicus|evm.model.PRDE01085862.1.1 P64988 Y2337_MYCBO 60.000 0.472 1.09649 BQ2027_MB2337 - Uncharacterized protein Mb2337 - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - BQ2027_MB2337 gene Indicus|evm.model.PRDE01085931.1.1 C5C7X8 GYRB_MICLC 83.636 0.981818 0.152778 gyrB - DNA gyrase subunit B - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - gyrB gene A type II topoisomerase that negatively supercoils DNA in an ATP-dependent manner (PubMed:276855). About 140 bp of DNA wraps around gyrase in the presence or absence of ATP, when ATP is added negative supercoils are made (PubMed:153201). Indicus|evm.model.PRDE01086068.1.1 P76389 YEGH_ECOLI 65.359 0.993289 0.282732 yegH - UPF0053 protein YegH - Escherichia coli (strain K12) - yegH gene plasma membrane Indicus|evm.model.PRDE01086184.1.1 Q0PEV3 PHYR_METEA 65.833 0.95935 0.460674 phyR - Phyllosphere-induced regulator PhyR - Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) - phyR gene Key regulator for adaptation to epiphytic life (leaf colonizing) of the bacterium. Positively regulates several genes including katE, sodA, hsp20, dps and gloA. However, it is not known whether this regulation is direct or indirect. Also induces several dehydrogenases. Indicus|evm.model.PRDE01086200.1.1 Q6FAA9 EFP_ACIAD 96.000 0.980198 0.526042 efp - Elongation factor P - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - efp gene Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-37 is required for alleviation. Indicus|evm.model.PRDE01086516.1.1 P33696 EXON_RHIME 49.689 0.969697 0.548173 exoN - UTP--glucose-1-phosphate uridylyltransferase - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - exoN gene Indicus|evm.model.PRDE01086620.1.1 C5C9Q5 EFTS_MICLC 90.909 0.993007 0.514388 tsf - Elongation factor Ts - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - tsf gene Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Indicus|evm.model.PRDE01086628.1.1 A3Q537 NUON_MYCSJ 64.324 0.994595 0.394456 nuoN - NADH-quinone oxidoreductase subunit N - Mycobacterium sp. (strain JLS) - nuoN gene NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Indicus|evm.model.PRDE01086725.1.1 P31475 YIEP_ECOLI 50.820 0.27907 0.934783 yieP - Uncharacterized HTH-type transcriptional regulator YieP - Escherichia coli (strain K12) - yieP gene cytosol Indicus|evm.model.PRDE01086837.1.1 B2GKD7 ASSY_KOCRD 76.471 0.867647 0.339152 argG - Argininosuccinate synthase - Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201) - argG gene Indicus|evm.model.PRDE01086949.1.1 Q8VZF1 AEE7_ARATH 60.656 0.991453 0.205624 AAE7 - Acetate/butyrate--CoA ligase AAE7, peroxisomal - Arabidopsis thaliana (Mouse-ear cress) - AAE7 gene Peroxisomal acetate/butyrate--CoA ligase that is probably involved in the activation of exogenous acetate for entry into the glyoxylate cycle. May play a role to prevent carbon loss from peroxisomes during lipid mobilization. In vitro, is active with both acetate and butyrate. Indicus|evm.model.PRDE01086990.1.1 B8GZM2 PLED_CAUVN 66.400 0.992 0.27533 pleD - Response regulator PleD - Caulobacter vibrioides (strain NA1000 / CB15N) - pleD gene Response regulator that is part of a signal transduction pathway controlling cell differentiation in the swarmer-to-stalked cell transition. Indicus|evm.model.PRDE01087013.1.1 P67126 Y1496_MYCBO 78.571 0.989071 0.216312 BQ2027_MB1496 - UPF0051 protein Mb1496 - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - BQ2027_MB1496 gene Indicus|evm.model.PRDE01087083.1.1 P23966 MENB_BACSU 45.522 0.948148 0.498155 menB - 1,4-dihydroxy-2-naphthoyl-CoA synthase - Bacillus subtilis (strain 168) - menB gene Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA). Indicus|evm.model.PRDE01087484.1.1 Q2W031 MAGA_MAGSA 50.943 0.693333 0.172811 magA - Iron transporter MagA - Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) - magA gene Iron transporter, which is required for the synthesis of bacterial magnetic particles (BMPs). Probably involved in the transport of iron from the environment into the cytoplasm across the cell membrane, and then from the cytoplasm into the BMP lipid vesicle across the BMP membrane. Indicus|evm.model.PRDE01087629.1.1 Q8XTY1 Y3414_RALSO 52.083 0.427273 0.359477 RSc3414 - UPF0187 protein RSc3414 - Ralstonia solanacearum (strain GMI1000) - RSc3414 gene Indicus|evm.model.PRDE01087729.1.2 B0SYY1 PYRG_CAUSK 94.690 0.99115 0.205455 pyrG - CTP synthase - Caulobacter sp. (strain K31) - pyrG gene Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. Indicus|evm.model.PRDE01088310.1.1 Q47NK1 DUT_THEFY 69.298 0.830882 0.759777 dut - Deoxyuridine 5'-triphosphate nucleotidohydrolase - Thermobifida fusca (strain YX) - dut gene This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Indicus|evm.model.PRDE01088507.1.1 P18913 FLJK_CAUVC 66.667 0.84127 0.230769 fljK - Flagellin FljK - Caulobacter vibrioides (strain ATCC 19089 / CB15) - fljK gene Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Indicus|evm.model.PRDE01088652.1.1 I6XD65 PNCA_MYCTU 49.223 0.994819 1.03763 pncA - Nicotinamidase/pyrazinamidase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - pncA gene Catalyzes the deamidation of nicotinamide (NAM) into nicotinate (PubMed:18201201). Likely functions in the cyclical salvage pathway for production of NAD from nicotinamide (By similarity). Indicus|evm.model.PRDE01088811.1.1 P23446 FLGG_BACSU 55.814 0.7 0.227273 flgG - Flagellar basal-body rod protein FlgG - Bacillus subtilis (strain 168) - flgG gene bacterial-type flagellum hook, bacterial-type flagellum assembly, bacterial-type flagellum-dependent swarming motility Indicus|evm.model.PRDE01089093.1.1 Q11UD1 FOLD_CYTH3 64.286 0.992063 0.434483 folD - Bifunctional protein FolD - Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465) - folD gene Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Indicus|evm.model.PRDE01089112.1.1 Q6F754 GBTR_ACIAD 80.220 0.967742 0.140909 ACIAD3460 - Glycine betaine transporter - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - ACIAD3460 gene Energy-dependent uptake of glycine betaine in response to high salinity. Indicus|evm.model.PRDE01089293.1.1 P60495 PXPB_BACSU 45.070 0.752809 0.370833 pxpB - 5-oxoprolinase subunit B - Bacillus subtilis (strain 168) - pxpB gene Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate (PubMed:28830929). In addition, is a potent inhibitor of the autophosphorylation reaction of kinase A (kinA) and its reverse reaction, but does not inhibit phosphate transfer to the Spo0F response regulator once kinase A is phosphorylated. Is an inhibitor of the catalytic domain of kinase A affecting the ATP/ADP reactions and not the phosphotransferase functions of this domain. The inhibition is non-competitive with respect to ATP (PubMed:9334321). Indicus|evm.model.PRDE01089650.1.1 Q6FEW7 RPPH_ACIAD 90.625 0.987578 0.96988 rppH - RNA pyrophosphohydrolase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - rppH gene Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. Indicus|evm.model.PRDE01089664.1.1 P39784 PCF_BACSU 94.624 0.978723 0.556213 xpf - Positive control factor - Bacillus subtilis (strain 168) - xpf gene Positive regulatory protein that acts at the late promoter PL. Indicus|evm.model.PRDE01090002.1.1 Q9I6J2 SPUC_PSEAE 55.200 0.992 0.274123 spuC - Putrescine--pyruvate aminotransferase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - spuC gene Involved in the putrescine catabolism. Catalyzes the transfer of the amino group from putrescine to pyruvate to yield 4-aminobutanal and alanine. Indicus|evm.model.PRDE01090016.1.1 Q54GK6 RL222_DICDI 60.000 0.862745 0.439655 rpl22a - 60S ribosomal protein L22 2 - Dictyostelium discoideum (Slime mold) - rpl22a gene RNA binding, structural constituent of ribosome, cytoplasmic translation Indicus|evm.model.PRDE01090046.1.1 O67115 SYW_AQUAE 64.103 0.747573 0.260759 trpS - Tryptophan--tRNA ligase - Aquifex aeolicus (strain VF5) - trpS gene Catalyzes the attachment of tryptophan to tRNA(Trp). Indicus|evm.model.PRDE01090125.1.1 Q04747 SRFAB_BACSU 95.172 0.993103 0.0404689 srfAB - Surfactin synthase subunit 2 - Bacillus subtilis (strain 168) - srfAB gene This protein is a multifunctional enzyme able to activate and polymerize the amino acids Leu, Glu, Asp and Val. Activation sites for these AA consist of individual domains. Indicus|evm.model.PRDE01090213.1.1 O07019 YVFU_BACSU 96.552 0.410072 0.695 yvfU - Uncharacterized transcriptional regulatory protein YvfU - Bacillus subtilis (strain 168) - yvfU gene Member of the two-component regulatory system YvfT/YvfU. Indicus|evm.model.PRDE01090270.1.1 Q88QF6 IPYR_PSEPK 73.643 0.984615 0.742857 ppa - Inorganic pyrophosphatase - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - ppa gene Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Indicus|evm.model.PRDE01090298.1.1 Q132Z6 CRCB_RHOPS 50.617 0.79798 0.798387 crcB - Putative fluoride ion transporter CrcB - Rhodopseudomonas palustris (strain BisB5) - crcB gene Important for reducing fluoride concentration in the cell, thus reducing its toxicity. Indicus|evm.model.PRDE01090338.1.1 Q8A0U2 TPIS_BACTN 57.237 0.862857 0.694444 tpiA - Triosephosphate isomerase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - tpiA gene Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). Indicus|evm.model.PRDE01090346.1.1 P40747 YUXG_BACSU 45.455 0.756522 0.166909 yuxG - Uncharacterized oxidoreductase YuxG - Bacillus subtilis (strain 168) - yuxG gene Indicus|evm.model.PRDE01090480.1.1 Q9X248 FABG_THEMA 47.945 0.841463 0.333333 fabG - 3-oxoacyl-[acyl-carrier-protein] reductase FabG - Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) - fabG gene Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Indicus|evm.model.PRDE01090535.1.1 Q7NLX2 PHK_GLOVI 74.101 0.654028 0.266078 glr0997 - Probable phosphoketolase - Gloeobacter violaceus (strain ATCC 29082 / PCC 7421) - glr0997 gene Indicus|evm.model.PRDE01090598.1.1 Q9AB72 DHSL_CAUVC 89.888 0.692913 0.346049 CC_0359 - Deoxyhypusine synthase-like protein - Caulobacter vibrioides (strain ATCC 19089 / CB15) - CC_0359 gene Indicus|evm.model.PRDE01090773.1.1 P28306 MLTG_ECOLI 55.952 0.976608 0.502941 mltG - Endolytic murein transglycosylase - Escherichia coli (strain K12) - mltG gene Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Indicus|evm.model.PRDE01090825.1.1 P19406 PPB4_BACSU 90.476 0.904348 0.249458 phoA - Alkaline phosphatase 4 precursor - Bacillus subtilis (strain 168) - phoA gene alkaline phosphatase activity, dephosphorylation Indicus|evm.model.PRDE01090891.1.1 Q9HVX2 GCH1L_PSEAE 57.971 0.957746 0.281746 PA4445 - GTP cyclohydrolase 1 type 2 homolog - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA4445 gene cytoplasm Indicus|evm.model.PRDE01090894.1.1 C5CC67 EFG_MICLC 73.585 0.995238 0.298295 fusA - Elongation factor G - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - fusA gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Indicus|evm.model.PRDE01090928.1.1 Q7W1C4 GCSP_BORPA 76.613 0.991935 0.129979 gcvP - Glycine dehydrogenase (decarboxylating) - Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) - gcvP gene The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Indicus|evm.model.PRDE01090962.1.1 P45868 MAO2_BACSU 96.053 0.974026 0.132302 maeA - Probable NAD-dependent malic enzyme 2 - Bacillus subtilis (strain 168) - maeA gene cytosol, malic enzyme activity, malate metabolic process, pyruvate metabolic process Indicus|evm.model.PRDE01090963.1.1 Q9X5V3 ATCU_RHILV 61.789 0.98374 0.146254 actP - Copper-transporting P-type ATPase - Rhizobium leguminosarum bv. viciae - actP gene Involved in copper efflux. Indicus|evm.model.PRDE01091289.1.2 P42973 BGLA_BACSU 58.837 0.993258 0.929019 bglA - Aryl-phospho-beta-D-glucosidase BglA - Bacillus subtilis (strain 168) - bglA gene Catalyzes the hydrolysis of aryl-phospho-beta-D-glucosides such as 4-methylumbelliferyl-phospho-beta-D-glucopyranoside (MUG-P), phosphoarbutin and phosphosalicin. Plays a major role in the utilization of arbutin or salicin as the sole carbon source. BglA and BglH are the major proteins contributing to hydrolysis of MUG-P by extracts of late-exponential-phase or stationary-phase B.subtilis cells. Indicus|evm.model.PRDE01091289.1.9 P32010 DRRA_STRPE 45.041 0.967611 0.748485 drrA - Daunorubicin/doxorubicin resistance ATP-binding protein DrrA - Streptomyces peucetius - drrA gene Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP. Indicus|evm.model.PRDE01091289.1.10 A0QV10 Y2408_MYCS2 46.970 0.899654 1.05091 MSMEG_2408 - Uncharacterized oxidoreductase MSMEG_2408/MSMEI_2347 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - MSMEG_2408 gene Indicus|evm.model.PRDE01091289.1.11 O32210 GR_BACSU 47.410 0.905455 0.996377 yvgN - Glyoxal reductase - Bacillus subtilis (strain 168) - yvgN gene Reduces glyoxal and methylglyoxal (2-oxopropanal). Is not involved in the vitamin B6 biosynthesis. Indicus|evm.model.PRDE01091289.1.18 Q49WS9 Y1627_STAS1 48.023 0.386667 1.82927 SSP1627 - Uncharacterized oxidoreductase SSP1627 - Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) - SSP1627 gene Indicus|evm.model.PRDE01091289.1.22 Q8GH68 MNTH_LACPL 52.861 0.824324 0.956897 mntH - Divalent metal cation transporter MntH - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - mntH gene H(+)-stimulated, divalent metal cation uptake system. Indicus|evm.model.PRDE01091289.1.25 P44099 Y1038_HAEIN 62.604 0.983562 0.9125 HI_1038 - Uncharacterized protein HI_1038 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_1038 gene Indicus|evm.model.PRDE01091289.1.26 P24944 GLTT_BACCA 56.338 0.994382 0.845606 gltT - Proton/sodium-glutamate symport protein - Bacillus caldotenax - gltT gene This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system. Indicus|evm.model.PRDE01091435.1.1 A6W7R2 DDL_KINRD 49.485 0.955446 0.537234 ddl - D-alanine--D-alanine ligase - Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) - ddl gene Cell wall formation. Indicus|evm.model.PRDE01091457.1.1 P94404 PADL_BACSU 97.917 0.979381 0.47549 bsdB - Probable UbiX-like flavin prenyltransferase - Bacillus subtilis (strain 168) - bsdB gene Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions (PubMed:18388975). Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase (By similarity). Indicus|evm.model.PRDE01091518.1.1 G3XCX3 PILU_PSEAE 65.000 0.527027 0.193717 pilU - Type IV pilus ATPase PilU - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pilU gene ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers (PubMed:7854122, PubMed:10377148, PubMed:15659660, PubMed:18174131). Functions as a PilT-dependent retraction ATPase, providing a functional coupling between PilT and PilU and an optimal mechanism for pilus retraction (PubMed:31525185, PubMed:31626631). Indicus|evm.model.PRDE01091522.1.1 B1LUN5 NUOC_METRJ 52.688 0.793103 0.539535 nuoC - NADH-quinone oxidoreductase subunit C - Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1) - nuoC gene NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Indicus|evm.model.PRDE01091525.1.1 Q6FFR5 DADA_ACIAD 91.667 0.990741 0.257757 dadA - D-amino acid dehydrogenase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - dadA gene Oxidative deamination of D-amino acids. Indicus|evm.model.PRDE01091623.1.1 A0A140N890 YGEA_ECOBD 45.813 0.99505 0.878261 ygeA - L-aspartate/glutamate-specific racemase - Escherichia coli (strain B / BL21-DE3) - ygeA gene Exhibits racemase activity for both L-glutamate and L-aspartate, but has threefold higher activity for L-glutamate than L-aspartate. Cannot use D-glutamate or D-aspartate as substrate. Indicus|evm.model.PRDE01091640.1.1 O31516 YESM_BACSU 87.838 0.986577 0.258232 yesM - Sensor histidine kinase YesM - Bacillus subtilis (strain 168) - yesM gene Member of the two-component regulatory system YesM/YesN. Probably activates YesN by phosphorylation. Indicus|evm.model.PRDE01091880.1.1 O31795 MIAA_BACSU 93.458 0.990654 0.340764 miaA - tRNA dimethylallyltransferase - Bacillus subtilis (strain 168) - miaA gene Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). Indicus|evm.model.PRDE01091913.1.1 Q9A5K4 PYRB_CAUVC 78.788 0.970297 0.304217 pyrB - Aspartate carbamoyltransferase - Caulobacter vibrioides (strain ATCC 19089 / CB15) - pyrB gene Indicus|evm.model.PRDE01092013.1.1 A9HY11 TRPC_BORPD 78.723 0.992908 0.538168 trpC - Indole-3-glycerol phosphate synthase - Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) - trpC gene Indicus|evm.model.PRDE01092065.1.1 P0AES8 GYRB_SHIFL 66.138 0.989474 0.236318 gyrB - DNA gyrase subunit B - Shigella flexneri - gyrB gene A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. Indicus|evm.model.PRDE01092093.1.1 A0QEW1 GLNE_MYCA1 69.355 0.968504 0.127255 glnE - Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme - Mycobacterium avium (strain 104) - glnE gene Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell. Indicus|evm.model.PRDE01092131.1.1 P9WJQ3 NARG_MYCTU 58.904 0.993103 0.117695 narG - Nitrate reductase alpha subunit - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - narG gene The alpha chain is the actual site of nitrate reduction (Probable). Supports anaerobic growth of E.coli on glycerol in an E.coli mutant lacking endogenous nitrate reductase. Indicus|evm.model.PRDE01092161.1.1 Q9ULI4 KI26A_HUMAN 84.524 0.965116 0.0456961 KIF26A - Kinesin-like protein KIF26A - Homo sapiens (Human) - KIF26A gene Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Indicus|evm.model.PRDE01092284.1.1 B8GX51 PIMT_CAUVN 65.686 0.990196 0.459459 pcm - Protein-L-isoaspartate O-methyltransferase - Caulobacter vibrioides (strain NA1000 / CB15N) - pcm gene Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Indicus|evm.model.PRDE01092363.1.1 O32180 YUSN_BACSU 98.182 0.981982 1.00909 yusN - Uncharacterized protein YusN - Bacillus subtilis (strain 168) - yusN gene Indicus|evm.model.PRDE01092396.1.1 Q9ABS9 GSHB_CAUVC 72.072 0.833333 0.416404 gshB - Glutathione synthetase - Caulobacter vibrioides (strain ATCC 19089 / CB15) - gshB gene Indicus|evm.model.PRDE01092402.1.1 Q52978 PHAAB_RHIME 71.429 0.45082 0.122122 phaAB - Probable K(+)/H(+) antiporter subunit A/B - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - phaAB gene Part of a K(+) efflux system which is required for the adaptation of R.meliloti to alkaline pH as well as for the infection process during symbiotic nodule development. Indicus|evm.model.PRDE01092512.1.1 B8H4E0 RS3_CAUVN 80.000 0.875 0.384 rpsC - 30S ribosomal protein S3 - Caulobacter vibrioides (strain NA1000 / CB15N) - rpsC gene Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. Indicus|evm.model.PRDE01092524.1.1 B7VS90 GUAC_VIBA3 70.874 0.971429 0.302594 guaC - GMP reductase - Vibrio atlanticus (strain LGP32) - guaC gene Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Indicus|evm.model.PRDE01092601.1.1 P0C112 AQPZ_BRUAB 54.248 0.993289 0.653509 aqpZ - Aquaporin Z - Brucella abortus biovar 1 (strain 9-941) - aqpZ gene Transport of water across the membrane. Possibly involved in the adaptation to variation in intravacuolar pH or osmolarity (By similarity). Indicus|evm.model.PRDE01092602.1.1 P54950 SCMK_BACSU 45.122 0.552448 0.324263 scmK - N-acetyl-S-(2-succino)cysteine monooxygenase - Bacillus subtilis (strain 168) - scmK gene Probably catalyzes the oxygenation of the 2-position of the succinyl moiety of N-acetyl-S-(2-succino)cysteine, causing a spontaneous elimination reaction of the resulting hemithioketal that generates oxaloacetate and N-acetylcysteine (NAC). Is involved in a S-(2-succino)cysteine (2SC) degradation pathway that allows B.subtilis to grow on 2SC as a sole sulfur source, via its metabolization to cysteine. Indicus|evm.model.PRDE01092614.1.1 Q6FCE6 HSCA_ACIAD 83.193 0.975207 0.195161 hscA - Chaperone protein HscA homolog - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - hscA gene Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Indicus|evm.model.PRDE01092634.1.1 P74876 DPO3X_SALTY 54.658 0.993789 0.250779 dnaX - DNA polymerase III subunit tau - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - dnaX gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity). Indicus|evm.model.PRDE01092943.1.1 Q3J5H6 GLND_RHOS4 48.413 0.976562 0.137634 glnD - Bifunctional uridylyltransferase/uridylyl-removing enzyme - Rhodobacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) - glnD gene Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. Indicus|evm.model.PRDE01092950.1.1 P0A102 PCAJ_PSEPU 55.556 0.915663 0.779343 pcaJ - 3-oxoadipate CoA-transferase subunit B - Pseudomonas putida - pcaJ gene Indicus|evm.model.PRDE01093116.1.1 Q9ZU77 GGPP7_ARATH 50.794 0.613861 0.291066 At2g18620 - Geranylgeranyl pyrophosphate synthase 7, chloroplastic precursor - Arabidopsis thaliana (Mouse-ear cress) - At2g18620 gene Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Indicus|evm.model.PRDE01093200.1.1 P37972 CNRA_CUPMC 49.180 0.978495 0.172862 cnrA - Nickel and cobalt resistance protein CnrA - Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) - cnrA gene The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni(2+) and Co(2+). The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter. Indicus|evm.model.PRDE01093231.1.1 P43010 PNTB_HAEIN 68.519 0.938596 0.240506 pntB - NAD(P) transhydrogenase subunit beta - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - pntB gene The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. Indicus|evm.model.PRDE01093283.1.1 B2T6I8 LSPA_PARPJ 62.712 0.690476 0.488372 lspA - Lipoprotein signal peptidase - Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) - lspA gene This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Indicus|evm.model.PRDE01093569.1.1 O52485 PUTA_KLEAE 70.833 0.712121 0.0503049 putA - Bifunctional protein PutA - Klebsiella aerogenes - putA gene Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon. Indicus|evm.model.PRDE01093590.1.1 P50620 RIR1_BACSU 45.397 0.990536 0.452857 nrdE - Ribonucleoside-diphosphate reductase subunit alpha - Bacillus subtilis (strain 168) - nrdE gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Indicus|evm.model.PRDE01093665.1.1 Q84M85 LOGL5_ORYSJ 50.588 0.831683 0.410569 LOGL5 - Probable cytokinin riboside 5'-monophosphate phosphoribohydrolase LOGL5 - Oryza sativa subsp. japonica (Rice) - LOGL5 gene Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms (By similarity). Indicus|evm.model.PRDE01093707.1.1 B0V6E0 RECA_ACIBY 81.699 0.980392 0.438395 recA - Protein RecA - Acinetobacter baumannii (strain AYE) - recA gene Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. Indicus|evm.model.PRDE01093715.1.1 P34940 CH60_PLAFG 54.717 0.96789 0.311429 Chaperonin CPN60, mitochondrial precursor - Plasmodium falciparum (isolate FCR-3 / Gambia) Indicus|evm.model.PRDE01094124.1.1 Q9I2S7 LDCA_PSEAE 64.925 0.992537 0.178429 ldcA - Lysine decarboxylase LdcA - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - ldcA gene Plays an essential role in lysine utilization by acting as a lysine decarboxylase. Indicus|evm.model.PRDE01094200.1.1 Q9A8N3 SYV_CAUVC 75.424 0.975 0.13245 valS - Valine--tRNA ligase - Caulobacter vibrioides (strain ATCC 19089 / CB15) - valS gene Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner. Indicus|evm.model.PRDE01094237.1.1 Q9KH33 IMDH_RHITR 72.973 0.848837 0.172691 guaB - Inosine-5'-monophosphate dehydrogenase - Rhizobium tropici - guaB gene Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Indicus|evm.model.PRDE01094331.1.1 Q9Z410 PHOU_PSEPU 64.356 0.961538 0.40625 phoU - Phosphate-specific transport system accessory protein PhoU homolog - Pseudomonas putida - phoU gene Plays a role in the regulation of phosphate uptake. Indicus|evm.model.PRDE01094346.1.1 O62327 GPX2_CAEEL 58.824 0.553719 0.742331 gpx-2 - Glutathione peroxidase 2 - Caenorhabditis elegans - gpx-2 gene May constitute a glutathione peroxidase-like protective system against oxidative stresses. Indicus|evm.model.PRDE01094355.1.1 Q9AB72 DHSL_CAUVC 72.381 0.936937 0.302452 CC_0359 - Deoxyhypusine synthase-like protein - Caulobacter vibrioides (strain ATCC 19089 / CB15) - CC_0359 gene Indicus|evm.model.PRDE01094489.1.1 Q5FS51 HTPG_GLUOX 56.209 0.974359 0.250401 htpG - Chaperone protein HtpG - Gluconobacter oxydans (strain 621H) - htpG gene Molecular chaperone. Has ATPase activity. Indicus|evm.model.PRDE01094581.1.1 P66874 Y1374_MYCBO 63.043 0.775862 0.212454 BQ2027_MB1374 - Uncharacterized protein Mb1374 - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - BQ2027_MB1374 gene Indicus|evm.model.PRDE01094593.1.1 A1SJK4 PYRG_NOCSJ 68.103 0.991379 0.203866 pyrG - CTP synthase - Nocardioides sp. (strain ATCC BAA-499 / JS614) - pyrG gene Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. Indicus|evm.model.PRDE01094603.1.1 P9WQA3 ALF_MYCTU 77.439 0.993902 0.476744 fba - Fructose-bisphosphate aldolase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - fba gene Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. Indicus|evm.model.PRDE01094639.1.1 P95596 DLDH_RHOCA 62.189 0.995025 0.442731 lpd - Dihydrolipoyl dehydrogenase - Rhodobacter capsulatus - lpd gene Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. Indicus|evm.model.PRDE01094664.1.1 Q88D09 MCPQ_PSEPK 59.375 0.992188 0.200627 mcpQ - Methyl-accepting chemotaxis protein McpQ - Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) - mcpQ gene Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. McpQ recognizes specifically citrate and citrate/metal(2+) complexes. Binds citrate/metal(2+) complexes with higher affinity than free citrate, and mediates preferentially chemotaxis toward citrate/metal(2+) complexes. Indicus|evm.model.PRDE01094903.1.1 P53984 ADDL_STRVG 51.429 0.978723 0.415929 Putative adenosine/adenine deaminase - Streptomyces virginiae Indicus|evm.model.PRDE01094970.1.1 P96687 YDFJ_BACSU 97.727 0.988701 0.244475 ydfJ - Membrane protein YdfJ - Bacillus subtilis (strain 168) - ydfJ gene Indicus|evm.model.PRDE01094988.1.1 Q07IE7 ILVD_RHOP5 80.519 0.980769 0.254072 ilvD - Dihydroxy-acid dehydratase - Rhodopseudomonas palustris (strain BisA53) - ilvD gene Indicus|evm.model.PRDE01095002.1.2 P9WIE1 BCP_MYCTU 50.746 0.956522 0.43949 bcp - Putative peroxiredoxin Rv2521 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - bcp gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Indicus|evm.model.PRDE01095055.1.1 Q6F9W4 LPTD_ACIAD 67.717 0.976744 0.157509 lptD - LPS-assembly protein LptD precursor - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - lptD gene Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Indicus|evm.model.PRDE01095118.1.1 P45946 ARSB_BACSU 59.459 0.932203 0.34104 arsB - Arsenite resistance protein ArsB - Bacillus subtilis (strain 168) - arsB gene Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump. Indicus|evm.model.PRDE01095288.1.1 P17984 YIA2_RHISP 57.895 0.268116 0.857143 Insertion element ISR1 uncharacterized 17 kDa protein A2 - Rhizobium sp. Indicus|evm.model.PRDE01095372.1.1 Q4K4K9 BETI_PSEF5 58.621 0.945055 0.461929 betI - HTH-type transcriptional regulator BetI - Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) - betI gene Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity). Indicus|evm.model.PRDE01095485.1.1 D3DJ41 2OCL_HYDTT 52.632 0.440252 0.243865 cfiA - 2-oxoglutarate carboxylase large subunit - Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6) - cfiA gene Indicus|evm.model.PRDE01095894.1.1 A9WSC4 SYA_RENSM 66.667 0.972603 0.0814732 alaS - Alanine--tRNA ligase - Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) - alaS gene Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. Indicus|evm.model.PRDE01096075.1.1 P45322 MODB_HAEIN 55.789 0.705426 0.563319 modB - Molybdenum transport system permease protein ModB - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - modB gene Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane. Indicus|evm.model.PRDE01096126.1.1 P15650 ACADL_RAT 61.224 0.284024 0.393023 Acadl - Long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Rattus norvegicus (Rat) - Acadl gene Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:3968063, PubMed:15466478). Indicus|evm.model.PRDE01096253.1.1 Q6FCR5 PYRB_ACIAD 89.189 0.996622 0.87574 pyrB - Aspartate carbamoyltransferase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - pyrB gene Indicus|evm.model.PRDE01096394.1.1 Q6FDS6 EFG_ACIAD 82.857 0.985816 0.198034 fusA - Elongation factor G - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - fusA gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Indicus|evm.model.PRDE01096628.1.1 A9IGJ9 PNP_BORPD 76.712 0.868263 0.232267 pnp - Polyribonucleotide nucleotidyltransferase - Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) - pnp gene Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Indicus|evm.model.PRDE01096816.1.1 O34990 PURU_BACSU 68.333 0.952 0.416667 purU - Formyltetrahydrofolate deformylase - Bacillus subtilis (strain 168) - purU gene Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). Indicus|evm.model.PRDE01097213.1.1 B0T2T7 ARLY_CAUSK 70.330 0.629371 0.314286 argH - Argininosuccinate lyase - Caulobacter sp. (strain K31) - argH gene Indicus|evm.model.PRDE01097441.1.1 P39342 YJGR_ECOLI 62.687 0.956835 0.278 yjgR - Uncharacterized protein YjgR - Escherichia coli (strain K12) - yjgR gene Indicus|evm.model.PRDE01097637.1.1 Q5RDG3 PREP_PONAB 55.357 0.778571 0.27001 PITRM1 - Presequence protease, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - PITRM1 gene Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. Indicus|evm.model.PRDE01097750.1.1 A0R567 MUTY_MYCS2 63.636 0.863309 0.474403 mutY - Adenine DNA glycosylase - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - mutY gene Adenine glycosylase active on G:A and C:A mispairs, as well as processing 7,8-dihydro-8-oxoguanine:A (8-oxoG) mismatches. Indicus|evm.model.PRDE01098133.1.1 Q8XU39 PH4H_RALSO 65.278 0.986207 0.463259 phhA - Phenylalanine-4-hydroxylase - Ralstonia solanacearum (strain GMI1000) - phhA gene Indicus|evm.model.PRDE01098213.1.1 A6KYJ6 RS10_BACV8 92.079 0.980392 1.0099 rpsJ - 30S ribosomal protein S10 - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - rpsJ gene Involved in the binding of tRNA to the ribosomes. Indicus|evm.model.PRDE01098461.1.1 Q608S5 AROA_METCA 50.549 0.436893 0.471396 aroA - 3-phosphoshikimate 1-carboxyvinyltransferase - Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) - aroA gene Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. Indicus|evm.model.PRDE01099030.1.1 B1JSQ9 BETB_YERPY 82.738 0.994012 0.340816 betB - Betaine aldehyde dehydrogenase - Yersinia pseudotuberculosis serotype O:3 (strain YPIII) - betB gene Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid. Indicus|evm.model.PRDE01099174.1.1 A1B4L2 ALDH_PARDP 67.901 0.493827 0.318898 adh - Aldehyde dehydrogenase - Paracoccus denitrificans (strain Pd 1222) - adh gene Catalyzes the NAD(+)-dependent oxidation of acetaldehyde to acetate. Indicus|evm.model.PRDE01099339.1.1 Q9HWB8 SBCC_PSEAE 52.261 0.989848 0.162675 sbcC - Nuclease SbcCD subunit C - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - sbcC gene SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity). Indicus|evm.model.PRDE01099373.1.1 Q97EZ6 GAL1_CLOAB 47.059 0.965116 0.22108 galK - Galactokinase - Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) - galK gene Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Indicus|evm.model.PRDE01099564.1.1 O83668 ALF_TREPA 75.424 0.818182 0.430723 fba - Fructose-bisphosphate aldolase - Treponema pallidum (strain Nichols) - fba gene Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. Indicus|evm.model.PRDE01099607.1.1 P34750 PILQ_PSEAE 52.532 0.956522 0.22549 pilQ - Fimbrial assembly protein PilQ precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pilQ gene Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane. Indicus|evm.model.PRDE01099652.1.1 Q58455 Y1055_METJA 47.619 0.912281 0.349693 MJ1055 - Uncharacterized protein MJ1055 - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) - MJ1055 gene Indicus|evm.model.PRDE01099701.1.1 P54428 YRKA_BACSU 46.591 0.656489 0.301843 yrkA - UPF0053 protein YrkA - Bacillus subtilis (strain 168) - yrkA gene Indicus|evm.model.PRDE01099873.1.1 B2FIJ0 LLDD_STRMK 78.495 0.92 0.263852 lldD - L-lactate dehydrogenase - Stenotrophomonas maltophilia (strain K279a) - lldD gene Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain. Indicus|evm.model.PRDE01100236.1.1 Q8Y5E4 DACA_LISMO 53.691 0.961039 0.564103 dacA - Diadenylate cyclase - Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) - dacA gene Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (PubMed:25605729). c-di-AMP is a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes (PubMed:20508090). Expression of truncated proteins (missing first 80 or 100 residues) in E.coli leads to c-di-AMP synthesis (PubMed:25605729). Indicus|evm.model.PRDE01100350.1.1 Q6FCU0 ADE_ACIAD 88.060 0.985185 0.406627 ACIAD1245 - Adenine deaminase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - ACIAD1245 gene Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. Indicus|evm.model.PRDE01100547.1.1 Q8AA75 PYRG_BACTN 64.024 0.993827 0.301676 pyrG - CTP synthase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - pyrG gene Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. Indicus|evm.model.PRDE01100560.1.1 P24517 RADA_SALTY 66.154 0.969697 0.143478 radA - DNA repair protein RadA - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - radA gene DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. Indicus|evm.model.PRDE01100838.1.1 B2IKA4 SYDND_BEII9 69.892 0.989247 0.155779 aspS - Aspartate--tRNA(Asp/Asn) ligase - Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIMB 8712) - aspS gene Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). Indicus|evm.model.PRDE01100913.1.1 Q89ZR8 PANC_BACTN 56.000 0.984127 0.446809 panC - Pantothenate synthetase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - panC gene Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Indicus|evm.model.PRDE01100940.1.1 P0AFF5 NUPG_SHIFL 48.438 0.863014 0.174641 nupG - Nucleoside permease NupG - Shigella flexneri - nupG gene Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force. Indicus|evm.model.PRDE01101079.1.1 Q5RAS0 ACADS_PONAB 44.444 0.684615 0.315534 ACADS - Short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - ACADS gene Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains. Indicus|evm.model.PRDE01101458.1.1 A6TP80 ACR3_ALKMQ 82.759 0.41791 0.187675 acr3 - Arsenical-resistance protein Acr3 - Alkaliphilus metalliredigens (strain QYMF) - acr3 gene Catalyzes arsenite efflux from the cell. Indicus|evm.model.PRDE01101460.1.1 P37798 ACCC_PSEAE 68.293 0.964286 0.187082 accC - Biotin carboxylase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - accC gene This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. Indicus|evm.model.PRDE01101605.1.1 P74038 RSMI_SYNY3 55.372 0.983471 0.433692 rsmI - Ribosomal RNA small subunit methyltransferase I - Synechocystis sp. (strain PCC 6803 / Kazusa) - rsmI gene Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. Indicus|evm.model.PRDE01101950.1.1 Q8KBD3 MNMA_CHLTE 53.704 0.980392 0.139344 mnmA - tRNA-specific 2-thiouridylase MnmA - Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) - mnmA gene Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. Indicus|evm.model.PRDE01102257.1.1 Q58546 G3P_METJA 47.436 0.927711 0.241983 gap - Glyceraldehyde-3-phosphate dehydrogenase - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) - gap gene Indicus|evm.model.PRDE01102395.1.1 P0A9T5 TAS_SHIFL 54.822 0.970297 0.583815 tas - Protein tas - Shigella flexneri - tas gene Indicus|evm.model.PRDE01102628.1.1 P0C0Z2 UVRA_BRUAB 60.452 0.983051 0.181725 uvrA - UvrABC system protein A - Brucella abortus biovar 1 (strain 9-941) - uvrA gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Indicus|evm.model.PRDE01102666.1.1 Q9LCK1 GYRB_CYTHU 56.688 0.993631 0.328452 gyrB - DNA gyrase subunit B - Cytophaga hutchinsonii - gyrB gene A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. Indicus|evm.model.PRDE01102772.1.1 Q83KW2 SUFB_SHIFL 71.111 0.985294 0.274747 sufB - FeS cluster assembly protein SufB - Shigella flexneri - sufB gene The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation (By similarity). Indicus|evm.model.PRDE01102801.1.1 A9KLS2 RIMO_LACP7 50.000 0.94898 0.222727 rimO - Ribosomal protein S12 methylthiotransferase RimO - Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) - rimO gene Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12. Indicus|evm.model.PRDE01102813.1.1 P14295 DHL2_WEICO 58.361 0.964968 1.0129 L-2-hydroxyisocaproate dehydrogenase - Weissella confusa Indicus|evm.model.PRDE01102813.1.7 P44697 THID_HAEIN 45.374 0.961538 0.869888 thiD - Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - thiD gene Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Indicus|evm.model.PRDE01102813.1.10 P39584 YWBA_BACSU 50.568 0.974286 0.788288 ywbA - Putative permease IIC component YwbA - Bacillus subtilis (strain 168) - ywbA gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. Indicus|evm.model.PRDE01102813.1.12 P45494 PEPV_LACDL 45.175 0.995575 0.961702 pepV - Beta-Ala-Xaa dipeptidase - Lactobacillus delbrueckii subsp. lactis - pepV gene Is a relatively unspecific dipeptidase cleaving a variety of dipeptides, notably those with an N-terminal beta-Ala or D-Ala residue, e.g. carnosine (beta-Ala-His). To a lesser extent, also shows aminopeptidase activity, since it is able to catalyze the removal of the N-terminal amino acid from a few distinct tripeptides. Indicus|evm.model.PRDE01102813.1.13 Q03HI6 SYY_PEDPA 95.455 0.994667 0.899281 tyrS - Tyrosine--tRNA ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - tyrS gene Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Indicus|evm.model.PRDE01102937.1.1 G8JZS4 SUSB_BACTN 61.905 0.899281 0.188347 susB - Glucan 1,4-alpha-glucosidase SusB precursor - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - susB gene Glucoamylase that hydrolyzes alpha-1,4-glucosidic linkages, alpha-1,6-, alpha-1,3- and alpha-1,2-glucosidic linkages during starch degradation. Indicus|evm.model.PRDE01102965.1.1 Q8A470 RPOC_BACTN 86.364 0.956044 0.0637701 rpoC - DNA-directed RNA polymerase subunit beta' - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - rpoC gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01103125.1.1 A6L4M1 ATPL_BACV8 60.526 0.536232 0.821429 atpE - ATP synthase subunit c - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - atpE gene F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Indicus|evm.model.PRDE01103336.1.1 Q8NQ52 RIBBA_CORGL 65.556 0.908163 0.232227 ribBA - Riboflavin biosynthesis protein RibBA - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - ribBA gene Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. Indicus|evm.model.PRDE01103339.1.1 A6TN07 G6PI_ALKMQ 67.708 0.748031 0.282222 pgi - Glucose-6-phosphate isomerase - Alkaliphilus metalliredigens (strain QYMF) - pgi gene Indicus|evm.model.PRDE01103394.1.1 Q58321 Y911_METJA 62.903 0.991935 0.339726 MJ0911 - Magnesium-chelatase subunit ChlI homolog - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) - MJ0911 gene Indicus|evm.model.PRDE01103397.1.1 Q8PCQ7 PUR4_XANCP 84.091 0.701613 0.0919881 purL - Phosphoribosylformylglycinamidine synthase - Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) - purL gene Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. Indicus|evm.model.PRDE01103444.1.1 A6LEG4 RL17_PARD8 67.143 0.985714 0.434783 rplQ - 50S ribosomal protein L17 - Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152) - rplQ gene Indicus|evm.model.PRDE01103471.1.1 Q3BSW1 TRHO_XANC5 70.629 0.986111 0.580645 trhO - tRNA uridine(34) hydroxylase - Xanthomonas campestris pv. vesicatoria (strain 85-10) - trhO gene Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. Indicus|evm.model.PRDE01103563.1.1 Q9HUW1 DUSB_PSEAE 71.429 0.991597 0.358434 dusB - tRNA-dihydrouridine synthase B - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - dusB gene Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Indicus|evm.model.PRDE01103846.1.1 Q8PT12 SERC_METMA 62.896 0.935897 0.632432 serC - Phosphoserine aminotransferase - Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) - serC gene Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Indicus|evm.model.PRDE01103965.1.1 O07631 BIPA_BACSU 54.478 0.985185 0.220588 bipA - 50S ribosomal subunit assembly factor BipA - Bacillus subtilis (strain 168) - bipA gene A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA. Indicus|evm.model.PRDE01104057.1.1 Q9HZ71 RS1_PSEAE 61.290 0.978723 0.168157 rpsA - 30S ribosomal protein S1 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - rpsA gene Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity). Indicus|evm.model.PRDE01104072.1.1 Q8UDM9 MURC_AGRFC 97.753 0.994382 0.377919 murC - UDP-N-acetylmuramate--L-alanine ligase - Agrobacterium fabrum (strain C58 / ATCC 33970) - murC gene Cell wall formation. Indicus|evm.model.PRDE01104075.1.1 Q4ZMG7 SURA_PSEU2 50.000 0.974684 0.184579 surA - Chaperone SurA precursor - Pseudomonas syringae pv. syringae (strain B728a) - surA gene Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. Indicus|evm.model.PRDE01104576.1.1 P56157 DPO3A_HELPY 32.903 0.961538 0.128819 dnaE - DNA polymerase III subunit alpha - Helicobacter pylori (strain ATCC 700392 / 26695) - dnaE gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity). Indicus|evm.model.PRDE01104605.1.1 O27390 DCDA_METTH 50.877 0.459016 0.285047 lysA - Diaminopimelate decarboxylase - Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) - lysA gene Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. Indicus|evm.model.PRDE01104643.1.1 A6KZJ2 MIAB_BACV8 77.301 0.97006 0.366228 miaB - tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - miaB gene Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. Indicus|evm.model.PRDE01104998.1.1 Q64PH7 RS6_BACFR 67.816 0.877551 0.859649 rpsF - 30S ribosomal protein S6 - Bacteroides fragilis (strain YCH46) - rpsF gene Binds together with S18 to 16S ribosomal RNA. Indicus|evm.model.PRDE01105092.1.1 P0C7J0 RMLB_XANCP 61.667 0.797297 0.210826 rfbB - dTDP-glucose 4,6-dehydratase - Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) - rfbB gene Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. Indicus|evm.model.PRDE01105197.1.1 P9WN19 GLTD_MYCTU 72.449 0.979798 0.202869 gltD - Glutamate synthase [NADPH] small chain - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - gltD gene cytosol, membrane, plasma membrane, electron transfer activity, anaerobic respiration Indicus|evm.model.PRDE01105460.1.1 Q67SC9 RL21_SYMTH 65.686 0.971154 1 rplU - 50S ribosomal protein L21 - Symbiobacterium thermophilum (strain T / IAM 14863) - rplU gene This protein binds to 23S rRNA in the presence of protein L20. Indicus|evm.model.PRDE01105514.1.1 Q08653 TRPE_THEMA 56.129 0.696833 0.479393 trpE - Anthranilate synthase component 1 - Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) - trpE gene Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity). Indicus|evm.model.PRDE01105520.1.1 Q8NNN0 MURE_CORGL 76.471 0.985294 0.131528 murE - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase - Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) - murE gene Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Indicus|evm.model.PRDE01105533.1.1 A6LHB0 PYRH_PARD8 80.916 0.977444 0.563559 pyrH - Uridylate kinase - Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152) - pyrH gene Catalyzes the reversible phosphorylation of UMP to UDP. Indicus|evm.model.PRDE01105577.1.1 O31489 YDCI_BACSU 56.701 0.932039 0.143255 ydcI - Uncharacterized protein YdcI - Bacillus subtilis (strain 168) - ydcI gene mRNA binding, structural constituent of ribosome, translation Indicus|evm.model.PRDE01105633.1.1 P22008 P5CR_PSEAE 60.920 0.977273 0.322344 proC - Pyrroline-5-carboxylate reductase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - proC gene Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. Indicus|evm.model.PRDE01105805.1.1 Q8EMI3 F16PC_OCEIH 54.745 0.985507 0.214286 fbp - Fructose-1,6-bisphosphatase class 3 - Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831) - fbp gene Indicus|evm.model.PRDE01106036.1.1 P10482 BGLS_CALSA 53.416 0.917647 0.373626 bglA - Beta-glucosidase A - Caldicellulosiruptor saccharolyticus - bglA gene Indicus|evm.model.PRDE01106108.1.1 A0R2W9 MCA_MYCS2 64.800 0.733728 0.586806 mca - Mycothiol S-conjugate amidase - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - mca gene A mycothiol (MSH, N-acetyl-cysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics. Activity is specific for the mycothiol moiety. Indicus|evm.model.PRDE01106453.1.1 Q8DW88 URDA_STRMU 49.231 0.853333 0.0933998 urdA - Urocanate reductase - Streptococcus mutans serotype c (strain ATCC 700610 / UA159) - urdA gene Catalyzes the two-electron reduction of urocanate to dihydrourocanate (also named imidazole propionate or deamino-histidine). Dihydrourocanate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria S.mutans strain UA159 may contribute to the pathogenesis of type 2 diabetes by producing the microbial metabolite dihydrourocanate. Indicus|evm.model.PRDE01106476.1.1 Q5QKR8 PSEB_CAMJJ 71.667 0.901515 0.39521 pseB - UDP-N-acetylglucosamine 4,6-dehydratase (inverting) - Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) - pseB gene Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose. Indicus|evm.model.PRDE01106524.1.1 Q038K0 TRMD_LACP3 78.182 0.964286 0.219608 trmD - tRNA (guanine-N(1)-)-methyltransferase - Lactobacillus paracasei (strain ATCC 334 / BCRC 17002 / CIP 107868 / KCTC 3260 / NRRL B-441) - trmD gene Specifically methylates guanosine-37 in various tRNAs. Indicus|evm.model.PRDE01106653.1.1 A6KXY5 ARGC_BACV8 69.421 0.952381 0.391304 argC - N-acetyl-gamma-glutamyl-phosphate reductase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - argC gene Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Indicus|evm.model.PRDE01106693.1.1 Q84KI6 SQD1_SPIOL 53.731 0.694737 0.197095 SQD1 - UDP-sulfoquinovose synthase, chloroplastic precursor - Spinacia oleracea (Spinach) - SQD1 gene Involved in the biosynthesis of sulfolipids found in thylakoid membranes. Converts UDP-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose. The sulfite is delivered to the reaction center by the FMN-binding domain of FdGOGAT. Indicus|evm.model.PRDE01106700.1.1 Q54316 HLYB_BRAHO 46.970 0.992424 0.15942 tlyB - Hemolysin B - Brachyspira hyodysenteriae - tlyB gene Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined. Indicus|evm.model.PRDE01106714.1.1 Q6F6Q6 CAPP_ACIAD 89.189 0.993243 0.165548 ppc - Phosphoenolpyruvate carboxylase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - ppc gene Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Indicus|evm.model.PRDE01106877.1.1 P94474 YEAC_BACSU 54.955 0.956522 0.359375 yeaC - Uncharacterized protein YeaC - Bacillus subtilis (strain 168) - yeaC gene Indicus|evm.model.PRDE01106996.1.1 Q6A7V5 SYFA_CUTAK 51.667 0.75641 0.211382 pheS - Phenylalanine--tRNA ligase alpha subunit - Cutibacterium acnes (strain DSM 16379 / KPA171202) - pheS gene Indicus|evm.model.PRDE01107025.1.1 A6L100 OBG_BACV8 58.889 0.741667 0.304569 obg - GTPase Obg - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - obg gene An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Indicus|evm.model.PRDE01107161.1.1 Q64ZR4 IF2_BACFR 71.429 0.981132 0.104433 infB - Translation initiation factor IF-2 - Bacteroides fragilis (strain YCH46) - infB gene One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. Indicus|evm.model.PRDE01107239.1.2 Q3IRL6 PYRH_NATPD 59.459 0.473684 0.334802 pyrH - Uridylate kinase - Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) - pyrH gene Catalyzes the reversible phosphorylation of UMP to UDP. Indicus|evm.model.PRDE01107281.1.1 Q8PFQ4 SPEE_XANAC 80.000 0.993548 0.54386 speE - Polyamine aminopropyltransferase - Xanthomonas axonopodis pv. citri (strain 306) - speE gene Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. Indicus|evm.model.PRDE01107344.1.1 P55577 Y4NA_SINFN 60.241 0.964286 0.231405 NGR_a02410 - Uncharacterized peptidase y4nA - Sinorhizobium fredii (strain NBRC 101917 / NGR234) - NGR_a02410 gene Indicus|evm.model.PRDE01107358.1.1 L7N689 TRCR_MYCTU 44.910 0.948276 0.677043 trcR - Transcriptional regulatory protein TrcR - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - trcR gene Member of the two-component regulatory system TrcS/TrcR (PubMed:10089160, PubMed:11914351). Activates its own expression by binding specifically to the AT-rich sequence of the trcR promoter region (PubMed:11914351). Also negatively regulates the expression of Rv1057 by binding to an AT-rich sequences within the Rv1057 upstream sequence (PubMed:16352831, PubMed:22099420). The TrcR-TrcS regulatory system may act as a transition regulatory system involved in adapting to an intracellular environment and transitioning from latency to reactivation (PubMed:11914351). Indicus|evm.model.PRDE01107384.1.1 A3M9P1 HIS6_ACIBT 93.902 0.987805 0.325397 hisF - Imidazole glycerol phosphate synthase subunit HisF - Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) - hisF gene IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. Indicus|evm.model.PRDE01107455.1.1 B0V8S1 HIS7_ACIBY 91.878 0.989899 0.980198 hisB - Imidazoleglycerol-phosphate dehydratase - Acinetobacter baumannii (strain AYE) - hisB gene Indicus|evm.model.PRDE01107552.1.1 P9WN37 GLN1A_MYCTU 50.000 0.955556 0.403587 glnA2 - Glutamine synthetase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - glnA2 gene Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes. Indicus|evm.model.PRDE01107633.1.1 O33952 UDG8_ECOLX 71.069 0.981366 0.414948 ugd - UDP-glucose 6-dehydrogenase - Escherichia coli - ugd gene Indicus|evm.model.PRDE01107634.1.1 Q2RNL4 SYT_RHORT 73.913 0.992754 0.214619 thrS - Threonine--tRNA ligase - Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) - thrS gene Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). Indicus|evm.model.PRDE01107646.1.1 O58495 IORA_PYRHO 57.647 0.864583 0.148148 iorA - Indolepyruvate oxidoreductase subunit IorA - Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) - iorA gene Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. Indicus|evm.model.PRDE01107853.1.1 C6DAW3 ARNT_PECCP 43.548 0.422535 0.255396 arnT - Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase - Pectobacterium carotovorum subsp. carotovorum (strain PC1) - arnT gene Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Indicus|evm.model.PRDE01107954.1.1 Q89A22 RHO_BUCBP 61.429 0.436709 0.377088 rho - Transcription termination factor Rho - Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) - rho gene Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template. Indicus|evm.model.PRDE01107964.1.1 Q9RVG1 HBD_DEIRA 46.667 0.993939 0.593525 hbd - Probable 3-hydroxybutyryl-CoA dehydrogenase - Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) - hbd gene Indicus|evm.model.PRDE01107980.1.1 Q9XC60 WBJC_PSEA1 45.522 0.886667 0.403226 wbjC - UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase - Pseudomonas aeruginosa (strain ATCC 29260 / BCRC 12902 / CIP 102967 / NCIMB 11965 / PA103) - wbjC gene Bifunctional enzyme that mediates C-3 epimerization of the second intermediate followed by reduction at C-4 during serogroup O11 O-antigen biosynthesis, thus catalyzing the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen. Indicus|evm.model.PRDE01108466.1.1 O31186 ADHA_RHIME 89.247 0.958333 0.282353 adhA - Alcohol dehydrogenase - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - adhA gene Indicus|evm.model.PRDE01108670.1.1 O54068 UDG_RHIME 56.934 0.992647 0.311213 rkpK - UDP-glucose 6-dehydrogenase - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - rkpK gene Indicus|evm.model.PRDE01108715.1.1 Q89YY3 CLPB_BACTN 56.250 0.964912 0.132251 clpB - Chaperone protein ClpB - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - clpB gene Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Indicus|evm.model.PRDE01108738.1.1 Q9WXE8 XYLO_PRERU 44.156 0.926829 0.158301 Putative beta-xylosidase - Prevotella ruminicola Indicus|evm.model.PRDE01108796.1.1 P0ABK1 CYDA_SHIFL 53.901 0.992908 0.270115 cydA - Cytochrome bd-I ubiquinol oxidase subunit 1 - Shigella flexneri - cydA gene A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron. Indicus|evm.model.PRDE01108799.1.1 Q43963 TRMD_ACIAD 87.204 0.889831 0.947791 trmD - tRNA (guanine-N(1)-)-methyltransferase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - trmD gene Specifically methylates guanosine-37 in various tRNAs. Indicus|evm.model.PRDE01108823.1.1 P82593 EABF_STRCX 46.296 0.958333 0.203636 Extracellular exo-alpha-L-arabinofuranosidase precursor - Streptomyces chartreusis Indicus|evm.model.PRDE01108856.1.1 Q8A8C3 DNAJ_BACTN 68.142 0.99115 0.285354 dnaJ - Chaperone protein DnaJ - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - dnaJ gene Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins. Indicus|evm.model.PRDE01108928.1.1 Q8EF99 SYFB_SHEON 46.980 0.982301 0.142138 pheT - Phenylalanine--tRNA ligase beta subunit - Shewanella oneidensis (strain MR-1) - pheT gene phenylalanine-tRNA ligase complex, phenylalanyl-tRNA aminoacylation Indicus|evm.model.PRDE01108940.1.1 A1JMC0 NUDL_YERE8 63.830 0.901961 0.261538 nudL - Uncharacterized Nudix hydrolase NudL - Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) - nudL gene Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. Indicus|evm.model.PRDE01109108.1.1 P0AGB2 SERB_SHIFL 48.718 0.950617 0.251553 serB - Phosphoserine phosphatase - Shigella flexneri - serB gene Catalyzes the dephosphorylation of phosphoserine (P-Ser). Indicus|evm.model.PRDE01109178.1.1 O66105 PPIB_TREPA 46.774 0.967742 0.288372 ppiB - Probable peptidyl-prolyl cis-trans isomerase - Treponema pallidum (strain Nichols) - ppiB gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Indicus|evm.model.PRDE01109197.1.1 Q8EUX9 PYRB_MYCPE 55.357 0.991071 0.373333 pyrB - Aspartate carbamoyltransferase - Mycoplasma penetrans (strain HF-2) - pyrB gene Indicus|evm.model.PRDE01109279.1.1 P44718 Y454_HAEIN 49.515 0.980583 0.396154 HI_0454 - Uncharacterized metal-dependent hydrolase HI_0454 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_0454 gene cytosol Indicus|evm.model.PRDE01109310.1.1 P0AFK6 POTC_ECOLI 48.000 0.91358 0.306818 potC - Spermidine/putrescine transport system permease protein PotC - Escherichia coli (strain K12) - potC gene Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Indicus|evm.model.PRDE01109342.1.1 Q06903 PPCE_AERHY 48.507 0.977612 0.194203 Prolyl endopeptidase - Aeromonas hydrophila Indicus|evm.model.PRDE01109442.1.1 O32034 TRHP1_BACSU 46.392 0.820513 0.277251 trhP1 - tRNA hydroxylation protein P1 - Bacillus subtilis (strain 168) - trhP1 gene Involved in prephenate-dependent formation of 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-methoxyuridine (mo5U) biosynthesis. Indicus|evm.model.PRDE01109469.1.1 Q8A2B1 SPEA_BACTN 75.000 0.98913 0.146032 speA - Biosynthetic arginine decarboxylase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - speA gene Catalyzes the biosynthesis of agmatine from arginine. Indicus|evm.model.PRDE01109489.1.1 Q0RFY2 LGT_FRAAA 50.000 0.443787 0.448276 lgt - Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase - Frankia alni (strain ACN14a) - lgt gene Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins. Indicus|evm.model.PRDE01109548.1.1 O52200 DNAG_MYCS2 68.000 0.859649 0.0896226 dnaG - DNA primase - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - dnaG gene RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Indicus|evm.model.PRDE01109548.1.2 C4LL80 NAGB_CORK4 67.073 0.94186 0.333333 nagB - Glucosamine-6-phosphate deaminase - Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717) - nagB gene Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. Indicus|evm.model.PRDE01109620.1.1 Q49XU5 XERD_STAS1 45.205 0.692308 0.352542 xerD - Tyrosine recombinase XerD - Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) - xerD gene Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. Indicus|evm.model.PRDE01109731.1.1 Q57752 Y304_METJA 50.000 0.827273 0.691824 MJ0304 - Uncharacterized protein MJ0304 - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) - MJ0304 gene Indicus|evm.model.PRDE01109809.1.1 B7GXS7 LON_ACIB3 67.910 0.863636 0.190358 lon - Lon protease - Acinetobacter baumannii (strain AB307-0294) - lon gene ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Indicus|evm.model.PRDE01109888.1.1 A9BJY3 MUTS_PETMO 60.526 0.81295 0.170135 mutS - DNA mismatch repair protein MutS - Petrotoga mobilis (strain DSM 10674 / SJ95) - mutS gene This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. Indicus|evm.model.PRDE01109994.1.1 A6KYH6 RL15_BACV8 63.953 0.988372 0.581081 rplO - 50S ribosomal protein L15 - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - rplO gene Binds to the 23S rRNA. Indicus|evm.model.PRDE01110461.1.1 Q86AX3 HUTU_DICDI 61.765 0.993976 0.247024 uroc1 - Probable urocanate hydratase - Dictyostelium discoideum (Slime mold) - uroc1 gene urocanate hydratase activity, histidine catabolic process Indicus|evm.model.PRDE01110727.1.1 Q8A2B1 SPEA_BACTN 82.514 0.973262 0.296825 speA - Biosynthetic arginine decarboxylase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - speA gene Catalyzes the biosynthesis of agmatine from arginine. Indicus|evm.model.PRDE01110854.1.1 A3M990 ENGB_ACIBT 83.019 0.820312 0.606635 engB - Probable GTP-binding protein EngB - Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) - engB gene Necessary for normal cell division and for the maintenance of normal septation. Indicus|evm.model.PRDE01110926.1.1 A6W6E9 ISPF_KINRD 80.328 0.896296 0.849057 ispF - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase - Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216) - ispF gene Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). Indicus|evm.model.PRDE01111516.1.1 A5CQS6 PYRH_CLAM3 68.627 0.971154 0.436975 pyrH - Uridylate kinase - Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382) - pyrH gene Catalyzes the reversible phosphorylation of UMP to UDP. Indicus|evm.model.PRDE01111577.1.1 P55037 GLTB_SYNY3 48.227 0.992908 0.0909677 gltB - Ferredoxin-dependent glutamate synthase 1 - Synechocystis sp. (strain PCC 6803 / Kazusa) - gltB gene glutamate synthase activity, oxidoreductase activity, ammonia assimilation cycle, glutamate biosynthetic process Indicus|evm.model.PRDE01111579.1.1 Q87YQ1 SYQ_PSESM 56.589 0.977099 0.230228 glnS - Glutamine--tRNA ligase - Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) - glnS gene Indicus|evm.model.PRDE01111766.1.1 O33289 ARGA_MYCTU 52.703 0.972603 0.41954 argA - Amino-acid acetyltransferase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - argA gene Catalyzes the conversion of L-glutamate to alpha-N-acetyl-L-glutamate. L-glutamine is a significantly better substrate compared to L-glutamate. Indicus|evm.model.PRDE01111911.1.1 O02464 OPS1_MANSE 83.065 0.97619 0.334218 OP1 - Opsin-1 - Manduca sexta (Tobacco hawkmoth) - OP1 gene Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May play a role in photoperiodic photoreception. Indicus|evm.model.PRDE01112074.1.1 P37624 RBBA_ECOLI 67.265 0.995516 0.244786 rbbA - Ribosome-associated ATPase - Escherichia coli (strain K12) - rbbA gene Exhibits an intrinsic ATPase activity that is stimulated by both 70S ribosomes and 30S ribosomal subunits. Could be involved in protein-chain elongation and in release of deacyl-tRNA from ribosomes after peptide bond synthesis. Stimulates the synthesis of polyphenylalanine in vitro. Indicus|evm.model.PRDE01112224.1.1 P36879 YADG_ECOLI 63.115 0.991803 0.396104 yadG - Uncharacterized ABC transporter ATP-binding protein YadG - Escherichia coli (strain K12) - yadG gene plasma membrane, response to X-ray Indicus|evm.model.PRDE01112281.1.1 Q4FQ66 SYFB_PSYA2 69.388 0.989796 0.122347 pheT - Phenylalanine--tRNA ligase beta subunit - Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4) - pheT gene Indicus|evm.model.PRDE01112309.1.1 A6L5E2 TSAD_BACV8 74.016 0.9 0.412979 tsaD - tRNA N6-adenosine threonylcarbamoyltransferase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - tsaD gene Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. Indicus|evm.model.PRDE01112587.1.1 Q52980 PHAC1_RHIME 72.642 0.990566 0.921739 phaC - Probable K(+)/H(+) antiporter subunit C - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - phaC gene Part of a K(+) efflux system which is required for the adaptation of R.meliloti to alkaline pH as well as for the infection process during symbiotic nodule development. Indicus|evm.model.PRDE01112691.1.1 A6KZP0 MNMG_BACV8 78.218 0.990099 0.162119 mnmG - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - mnmG gene NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Indicus|evm.model.PRDE01112701.1.1 Q9A3Y4 ARGJ_CAUVC 74.847 0.947368 0.424318 argJ - Arginine biosynthesis bifunctional protein ArgJ - Caulobacter vibrioides (strain ATCC 19089 / CB15) - argJ gene Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Indicus|evm.model.PRDE01112762.1.1 Q8KY18 DHA_MYCSM 62.651 0.97619 0.226415 ald - Alanine dehydrogenase - Mycolicibacterium smegmatis - ald gene Catalyzes the reversible reductive amination of pyruvate to L-alanine. It is required for proficient utilization of alanine as a nitrogen source. May play an important role in growth under anaerobic conditions. Indicus|evm.model.PRDE01112949.1.1 Q8AA38 Y627_BACTN 56.140 0.933333 0.242915 BT_0627 - Probable transcriptional regulatory protein BT_0627 - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - BT_0627 gene cytosol Indicus|evm.model.PRDE01112949.1.2 D5EY13 XYFA_PRER2 48.333 0.447154 0.169421 xyn10D-fae1A - Endo-1,4-beta-xylanase/feruloyl esterase precursor - Prevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23) - xyn10D-fae1A gene Involved in degradation of plant cell wall polysaccharides. Has endo-xylanase activity towards substrates such as oat spelt xylan (OSX), acetylated xylo-oligosaccharides and acetylated xylan, producing primarily xylobiose; cannot hydrolyze xylobiose to xylose. Also has feruloyl esterase activity, releasing ferulic acid from methylferulate, and from the more natural substrates wheat bran, corn fiber, and XOS(FA,Ac), a corn fiber-derived substrate enriched in O-acetyl and ferulic acid esters. Exhibits negligible acetyl esterase activity on sugar acetates. Acts synergistically with Xyl3A to increase the release of xylose from xylan. Does not possess endoglucanase or mannanase activities since it is not able to hydrolyze carboxymethyl cellulose and locust bean gum. Indicus|evm.model.PRDE01113395.1.1 P05682 REPA_AGRRH 73.276 0.974576 0.292079 repA - Putative replication protein A - Agrobacterium rhizogenes - repA gene This protein is coded by a hairy root Ri plasmid. It is possibly involved in regulating the plasmid copy-number. Indicus|evm.model.PRDE01113407.1.1 A6KZL1 METK_BACV8 67.836 0.994083 0.393023 metK - S-adenosylmethionine synthase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - metK gene Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Indicus|evm.model.PRDE01113425.1.1 Q94AU7 GCA3_ARATH 50.000 0.820144 0.53876 GAMMACA3 - Gamma carbonic anhydrase 3, mitochondrial precursor - Arabidopsis thaliana (Mouse-ear cress) - GAMMACA3 gene Enzyme involved in the catabolism of H(2)CO(3) but that does not mediates the reversible hydration of carbon dioxide. Mediates complex I assembly in mitochondria and respiration (By similarity). Indicus|evm.model.PRDE01113509.1.1 B1MZ74 CARB_LEUCK 59.500 0.989899 0.186969 carB - Carbamoyl-phosphate synthase large chain - Leuconostoc citreum (strain KM20) - carB gene Indicus|evm.model.PRDE01113686.1.1 Q5YZ21 TRPD_NOCFA 57.979 0.983425 0.524638 trpD - Anthranilate phosphoribosyltransferase - Nocardia farcinica (strain IFM 10152) - trpD gene Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA). Indicus|evm.model.PRDE01113700.1.1 P04174 DYR_NEIGO 57.955 0.699187 0.759259 folA - Dihydrofolate reductase - Neisseria gonorrhoeae - folA gene Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). Indicus|evm.model.PRDE01113711.1.1 P50215 IDH_SPHYA 69.298 0.982609 0.283251 icd - Isocitrate dehydrogenase [NADP] - Sphingobium yanoikuyae - icd gene Indicus|evm.model.PRDE01113861.1.1 P39879 Y2026_PSEAE 47.407 0.93617 0.423423 PA2026 - Uncharacterized protein PA2026 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA2026 gene plasma membrane Indicus|evm.model.PRDE01113935.1.1 Q9X913 HPPA_STRCO 66.834 0.994624 0.234257 hppA - K(+)-insensitive pyrophosphate-energized proton pump - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - hppA gene Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. Indicus|evm.model.PRDE01114030.1.1 B8GYF1 FMT_CAUVN 70.339 0.92 0.405844 fmt - Methionyl-tRNA formyltransferase - Caulobacter vibrioides (strain NA1000 / CB15N) - fmt gene Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. Indicus|evm.model.PRDE01114214.1.1 Q7MT06 YQGF_PORGI 56.436 0.970874 0.746377 PG_2202 - Putative pre-16S rRNA nuclease - Porphyromonas gingivalis (strain ATCC BAA-308 / W83) - PG_2202 gene Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. Indicus|evm.model.PRDE01114247.1.1 P96169 SGLT_VIBPH 57.971 0.992754 0.254144 sglT - Sodium/glucose cotransporter - Vibrio parahaemolyticus - sglT gene Actively transports glucose into cells by Na(+) cotransport. Indicus|evm.model.PRDE01114298.1.1 P9WGG9 RPSD_MYCTU 60.000 0.992 0.589623 sigD - ECF RNA polymerase sigma factor SigD - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - sigD gene Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis. Indicus|evm.model.PRDE01114387.1.1 A0JZC2 MSHD_ARTS2 76.056 0.921053 0.235294 mshD - Mycothiol acetyltransferase - Arthrobacter sp. (strain FB24) - mshD gene Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. Indicus|evm.model.PRDE01114387.1.2 P9WIY3 MUTT1_MYCTU 51.948 0.712871 0.318612 mutT1 - 8-oxo-(d)GTP phosphatase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - mutT1 gene Catalyzes the conversion of 8-oxo-dGTP to 8-oxo-dGDP, and 8-oxo-GTP to 8-oxo-GDP (PubMed:23463507, PubMed:16585780). Functions in concert with Rv1700 to detoxify 8-oxo-dGTP to 8-oxo-dGMP and plays an important role in supporting cellular growth under oxidative stress (PubMed:23463507). Indicus|evm.model.PRDE01114399.1.1 P50507 RPOH_RHIRD 50.962 0.990196 0.34 rpoH - RNA polymerase sigma factor RpoH - Rhizobium radiobacter (Agrobacterium tumefaciens) - rpoH gene Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. Indicus|evm.model.PRDE01114509.1.1 Q45480 YLYB_BACSU 48.361 0.909774 0.438944 ylyB - Uncharacterized RNA pseudouridine synthase YlyB - Bacillus subtilis (strain 168) - ylyB gene pseudouridine synthase activity, enzyme-directed rRNA pseudouridine synthesis Indicus|evm.model.PRDE01115006.1.1 A6L5X9 Y3469_BACV8 76.744 0.984615 0.528455 BVU_3469 - Probable transcriptional regulatory protein BVU_3469 - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - BVU_3469 gene Indicus|evm.model.PRDE01115154.1.1 Q12L71 SSTT_SHEDO 70.115 0.819048 0.257985 sstT - Serine/threonine transporter SstT - Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) - sstT gene Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Indicus|evm.model.PRDE01115182.1.1 Q7MT83 KPRS_PORGI 60.800 0.992 0.399361 prs - Ribose-phosphate pyrophosphokinase - Porphyromonas gingivalis (strain ATCC BAA-308 / W83) - prs gene Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). Indicus|evm.model.PRDE01115324.1.1 Q9HVN5 CLPB_PSEAE 73.333 0.856115 0.162763 clpB - Chaperone protein ClpB - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - clpB gene Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Indicus|evm.model.PRDE01115396.1.1 A6L7J7 SYT_BACV8 78.481 0.987342 0.122291 thrS - Threonine--tRNA ligase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - thrS gene Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). Indicus|evm.model.PRDE01115433.1.1 O50628 GYRA_BACHD 53.459 0.969325 0.195678 gyrA - DNA gyrase subunit A - Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) - gyrA gene A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. Indicus|evm.model.PRDE01115531.1.1 A6V0X2 LEU1_PSEA7 67.391 0.992754 0.248201 leuA - 2-isopropylmalate synthase - Pseudomonas aeruginosa (strain PA7) - leuA gene Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Indicus|evm.model.PRDE01115595.1.1 Q9I0J8 NUOE_PSEAE 55.556 0.894118 1.0241 nuoE - NADH-quinone oxidoreductase subunit E - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - nuoE gene NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity). Indicus|evm.model.PRDE01115771.1.1 A6KZK0 QUEA_BACV8 68.750 0.987578 0.458689 queA - S-adenosylmethionine:tRNA ribosyltransferase-isomerase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - queA gene Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). Indicus|evm.model.PRDE01115939.1.1 P33164 PDR_BURCE 50.000 0.822581 0.192547 ophA1 - Phthalate dioxygenase reductase - Burkholderia cepacia - ophA1 gene Component of the electron transfer chain involved in pyridine nucleotide-dependent dihydroxylation of phthalate. Utilizes FMN to mediate electron transfer from the two-electron donor, NADH, to the one-electron acceptor, (2Fe-2S). Indicus|evm.model.PRDE01116040.1.1 A6L7P7 G6PI_BACV8 68.868 0.9375 0.250559 pgi - Glucose-6-phosphate isomerase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - pgi gene Indicus|evm.model.PRDE01116159.1.1 Q8A9J2 UXAC_BACTN 64.706 0.985401 0.292735 uxaC - Uronate isomerase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - uxaC gene D-galacturonate catabolic process, D-glucuronate catabolic process Indicus|evm.model.PRDE01116261.1.1 B4RCD1 RS16_PHEZH 78.481 0.886364 0.494382 rpsP - 30S ribosomal protein S16 - Phenylobacterium zucineum (strain HLK1) - rpsP gene Indicus|evm.model.PRDE01116351.1.1 P39347 INTB_ECOLI 49.057 0.675325 0.194444 intB - Putative protein IntB - Escherichia coli (strain K12) - intB gene Indicus|evm.model.PRDE01116415.1.1 Q4FSF9 ARGJ_PSYA2 75.000 0.962264 0.130221 argJ - Arginine biosynthesis bifunctional protein ArgJ - Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4) - argJ gene Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Indicus|evm.model.PRDE01116660.1.1 A5WGA8 DER_PSYWF 75.806 0.995968 0.524313 der - GTPase Der - Psychrobacter sp. (strain PRwf-1) - der gene GTPase that plays an essential role in the late steps of ribosome biogenesis. Indicus|evm.model.PRDE01116763.1.1 O28753 ISF2_ARCFU 46.154 0.385542 0.851282 AF_1519 - Iron-sulfur flavoprotein AF_1519 - Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) - AF_1519 gene Redox-active protein probably involved in electron transport. Indicus|evm.model.PRDE01116830.1.1 O32177 FADA_BACSU 45.528 0.853147 0.365729 fadA - 3-ketoacyl-CoA thiolase - Bacillus subtilis (strain 168) - fadA gene Involved in the degradation of long-chain fatty acids. Indicus|evm.model.PRDE01116909.1.1 P9WH03 RNC_MYCTU 65.385 0.793814 0.404167 rnc - Ribonuclease 3 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - rnc gene Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity). Indicus|evm.model.PRDE01116910.1.1 B9DPU2 MUTS2_STACT 45.977 0.726415 0.13555 mutS2 - Endonuclease MutS2 - Staphylococcus carnosus (strain TM300) - mutS2 gene Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity. Indicus|evm.model.PRDE01117162.1.1 A0B8B3 HIS3_METTP 76.119 0.825 0.661157 hisI - Phosphoribosyl-AMP cyclohydrolase - Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) - hisI gene Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. Indicus|evm.model.PRDE01117369.1.1 Q8A2B1 SPEA_BACTN 71.667 0.881481 0.214286 speA - Biosynthetic arginine decarboxylase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - speA gene Catalyzes the biosynthesis of agmatine from arginine. Indicus|evm.model.PRDE01117470.1.1 A8HS15 ATPA_AZOC5 71.963 0.785185 0.264706 atpA - ATP synthase subunit alpha - Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571) - atpA gene Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Indicus|evm.model.PRDE01117518.1.1 F4JQH3 AMPP1_ARATH 55.455 0.972727 0.170543 APP1 - Aminopeptidase P1 - Arabidopsis thaliana (Mouse-ear cress) - APP1 gene Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity). Aminopeptidase that binds to the auxin transport inhibitor N-1-naphthylphthalamic acid (NPA). May play a negative role in the regulation of PIN auxin transport proteins (PubMed:11891249). Indicus|evm.model.PRDE01117557.1.1 Q6FE14 DAPE_ACIAD 94.737 0.321739 0.30504 dapE - Succinyl-diaminopimelate desuccinylase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - dapE gene Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Indicus|evm.model.PRDE01117645.1.1 P44190 Y1419_HAEIN 64.286 0.333333 1.66667 HI_1419 - Uncharacterized protein HI_1419 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_1419 gene Indicus|evm.model.PRDE01117684.1.1 Q8A7Z7 HIS2_BACTN 71.111 0.872549 0.502463 hisI - Histidine biosynthesis bifunctional protein HisIE - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - hisI gene Indicus|evm.model.PRDE01118082.1.1 A6L064 RS20_BACV8 80.952 0.976471 1.0119 rpsT - 30S ribosomal protein S20 - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - rpsT gene Binds directly to 16S ribosomal RNA. Indicus|evm.model.PRDE01118108.1.1 Q65N90 TOP3_BACLD 45.161 0.980645 0.213205 topB - DNA topoisomerase 3 - Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46) - topB gene Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Indicus|evm.model.PRDE01118222.1.1 P55643 Y4RJ_SINFN 57.229 0.981481 0.409091 NGR_a01770 - Putative transposase y4rJ - Sinorhizobium fredii (strain NBRC 101917 / NGR234) - NGR_a01770 gene Indicus|evm.model.PRDE01118246.1.1 A6L3C0 SSRP_BACV8 57.843 0.971154 0.693333 smpB - SsrA-binding protein - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - smpB gene Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. Indicus|evm.model.PRDE01118598.1.1 Q92R45 ARREH_RHIME 77.698 0.978723 0.585062 arsH - NADPH-dependent FMN reductase ArsH - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - arsH gene Has NADPH-dependent FMN reductase activity. No activity with NADH. May play a role in resistance to heavy metal toxicity. Indicus|evm.model.PRDE01118730.1.1 O33062 SERC_MYCLE 63.910 0.977778 0.359043 serC - Putative phosphoserine aminotransferase - Mycobacterium leprae (strain TN) - serC gene Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Indicus|evm.model.PRDE01118788.1.1 O34383 YOCR_BACSU 48.837 0.876289 0.217978 yocR - Uncharacterized sodium-dependent transporter YocR - Bacillus subtilis (strain 168) - yocR gene Putative sodium-dependent transporter. Indicus|evm.model.PRDE01118842.1.1 P55892 MOTB_SALTY 59.677 0.518519 0.349515 motB - Motility protein B - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - motB gene MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity). Indicus|evm.model.PRDE01118974.1.1 P0AAZ4 RARA_ECOLI 60.000 0.895652 0.257271 rarA - Replication-associated recombination protein A - Escherichia coli (strain K12) - rarA gene DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. Indicus|evm.model.PRDE01119180.1.1 Q53612 DHAS_STRAK 60.000 0.653333 0.221893 asd - Aspartate-semialdehyde dehydrogenase - Streptomyces akiyoshiensis - asd gene Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate. Indicus|evm.model.PRDE01119244.1.1 P74547 CYSW_SYNY3 53.962 0.727273 1.31522 cysW - Sulfate transport system permease protein CysW - Synechocystis sp. (strain PCC 6803 / Kazusa) - cysW gene Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane (By similarity). Indicus|evm.model.PRDE01119249.1.1 B7GIY1 ACPS_ANOFW 50.427 0.97479 0.991667 acpS - Holo-[acyl-carrier-protein] synthase - Anoxybacillus flavithermus (strain DSM 21510 / WK1) - acpS gene Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. Indicus|evm.model.PRDE01119263.1.1 Q57168 T1MH_HAEIN 59.055 0.969231 0.293454 HI_1287 - Putative type I restriction enzyme HindVIIP M protein - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_1287 gene Methylation of specific adenine residues; required for both restriction and modification activities. Indicus|evm.model.PRDE01119277.1.1 O84549 DPO3A_CHLTR 53.600 0.992 0.101051 dnaE - DNA polymerase III subunit alpha - Chlamydia trachomatis (strain D/UW-3/Cx) - dnaE gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity). Indicus|evm.model.PRDE01119459.1.1 Q6D259 ISCS_PECAS 80.137 0.993151 0.361386 iscS - Cysteine desulfurase IscS - Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) - iscS gene Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Indicus|evm.model.PRDE01119472.1.1 Q2KD88 MIAB_RHIEC 81.818 0.532787 0.260128 miaB - tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase - Rhizobium etli (strain CFN 42 / ATCC 51251) - miaB gene Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. Indicus|evm.model.PRDE01119535.1.1 P94300 UBIX_ALKPO 56.140 0.589474 0.475 ubiX - Flavin prenyltransferase UbiX - Alkalihalobacillus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4) - ubiX gene Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN. Indicus|evm.model.PRDE01119551.1.1 B0VBN5 SYR_ACIBY 70.690 0.851852 0.22651 argS - Arginine--tRNA ligase - Acinetobacter baumannii (strain AYE) - argS gene Indicus|evm.model.PRDE01119587.1.1 Q46507 HNDC_DESFR 69.565 0.982759 0.236735 hndC - NADP-reducing hydrogenase subunit HndC - Desulfovibrio fructosivorans - hndC gene Catalyzes the reduction of NADP in the presence of molecular H2 to yield NADPH. Indicus|evm.model.PRDE01119861.1.1 A7LXU3 BGH3B_BACO1 70.787 0.994318 0.223919 BACOVA_02659 - Beta-glucosidase BoGH3B precursor - Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / NCTC 11153) - BACOVA_02659 gene Catalyzes the hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose in xyloglucan degradation, leading to remove the backbone 'G' units. Indicus|evm.model.PRDE01119930.1.1 Q5A310 ISW2_CANAL 48.598 0.832 0.118371 ISW2 - ISWI chromatin-remodeling complex ATPase ISW2 - Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) - ISW2 gene Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens. Indicus|evm.model.PRDE01120007.1.1 P0C938 HTPG_PORGI 80.412 0.989691 0.141813 htpG - Chaperone protein HtpG - Porphyromonas gingivalis (strain ATCC BAA-308 / W83) - htpG gene Molecular chaperone. Has ATPase activity. Indicus|evm.model.PRDE01120101.1.1 B0V5P7 PANC_ACIBY 87.943 0.992908 0.5 panC - Pantothenate synthetase - Acinetobacter baumannii (strain AYE) - panC gene Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Indicus|evm.model.PRDE01120152.1.1 A5E0U9 DBP8_LODEL 52.809 0.727273 0.272523 DBP8 - ATP-dependent RNA helicase DBP8 - Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) - DBP8 gene ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity). Indicus|evm.model.PRDE01120181.1.1 Q59156 DPO1_CALBD 54.305 0.980392 0.18 polA - DNA polymerase I - Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) - polA gene In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. Indicus|evm.model.PRDE01120287.1.1 Q3J2B7 PRMC_RHOS4 45.161 0.938272 0.582734 prmC - Release factor glutamine methyltransferase - Rhodobacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) - prmC gene Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. Indicus|evm.model.PRDE01120402.1.1 A6L227 RNY_BACV8 86.364 0.973214 0.219178 rny - Ribonuclease Y - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - rny gene Endoribonuclease that initiates mRNA decay. Indicus|evm.model.PRDE01120684.1.1 Q9Z6S5 RIR1_CHLPN 66.667 0.944444 0.0689655 nrdA - Ribonucleoside-diphosphate reductase subunit alpha - Chlamydia pneumoniae - nrdA gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Indicus|evm.model.PRDE01120811.1.1 Q6AHF2 CPFC_LEIXX 64.286 0.822485 0.434447 cpfC - Coproporphyrin III ferrochelatase - Leifsonia xyli subsp. xyli (strain CTCB07) - cpfC gene Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III. Indicus|evm.model.PRDE01120912.1.1 P37213 PPDK_ENTHI 54.237 0.848485 0.0745763 PPDK - Pyruvate, phosphate dikinase - Entamoeba histolytica - PPDK gene Catalyzes the reversible phosphorylation of pyruvate and phosphate. In E.histolytica and C.symbiosus, PPDK functions in the direction of ATP synthesis. Indicus|evm.model.PRDE01121030.1.1 B0S6C5 RTSTL_DANRE 50.000 0.361842 0.251656 retsatl - Inactive all-trans-retinol 13,14-reductase precursor - Danio rerio (Zebrafish) - retsatl gene Indicus|evm.model.PRDE01121079.1.1 P9WNP3 HTDZ_MYCTU 53.390 0.943089 0.81457 htdZ - 3-hydroxyacyl-thioester dehydratase Z - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - htdZ gene Shows trans-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydratase activity. In vitro, can hydrate (2E)-butenoyl-CoA, (2E)-hexenoyl-CoA and (2E)-decenoyl-CoA. Indicus|evm.model.PRDE01121107.1.1 Q6FD29 PYRC_ACIAD 92.308 0.974684 0.229651 pyrC - Dihydroorotase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - pyrC gene Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. Indicus|evm.model.PRDE01121121.1.1 Q9WZY4 METY_THEMA 51.449 0.971631 0.327907 TM_0882 - O-acetyl-L-homoserine sulfhydrylase - Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) - TM_0882 gene Catalyzes the production of homocysteine from O-acetylhomoserine (OAH) and hydrogen sulfide (H2S), a step in the methionine biosynthesis pathway. Is not able to form cystathionine from O-acetylhomoserine and L-cysteine. Indicus|evm.model.PRDE01121158.1.1 P51776 PPDK_GIAIN 66.667 0.966292 0.100679 Pyruvate, phosphate dikinase - Giardia intestinalis Indicus|evm.model.PRDE01121248.1.1 A1W4E1 SYDND_ACISJ 93.464 0.95 0.26534 aspS - Aspartate--tRNA(Asp/Asn) ligase - Acidovorax sp. (strain JS42) - aspS gene Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). Indicus|evm.model.PRDE01121383.1.1 Q83E37 FABF_COXBU 82.609 0.366667 0.144928 fabF - 3-oxoacyl-[acyl-carrier-protein] synthase 2 - Coxiella burnetii (strain RSA 493 / Nine Mile phase I) - fabF gene Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. Indicus|evm.model.PRDE01121462.1.1 P39616 ALDH2_BACSU 48.889 0.972826 0.403509 ywdH - Putative aldehyde dehydrogenase YwdH - Bacillus subtilis (strain 168) - ywdH gene Indicus|evm.model.PRDE01121660.1.1 A4VUQ8 XERS_STRSY 45.455 0.860465 0.241573 xerS - Tyrosine recombinase XerS - Streptococcus suis (strain 05ZYH33) - xerS gene Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. Indicus|evm.model.PRDE01121717.1.1 Q7MVU9 Y934_PORGI 67.532 0.987013 0.121451 PG_0934 - UPF0313 protein PG_0934 - Porphyromonas gingivalis (strain ATCC BAA-308 / W83) - PG_0934 gene Indicus|evm.model.PRDE01121737.1.1 Q9HZQ3 COBN_PSEAE 48.855 0.984848 0.105769 cobN - Aerobic cobaltochelatase subunit CobN - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - cobN gene Catalyzes cobalt insertion in the corrin ring. Indicus|evm.model.PRDE01121795.1.1 O32222 CSOR_BACSU 48.750 0.975 0.792079 csoR - Copper-sensing transcriptional repressor CsoR - Bacillus subtilis (strain 168) - csoR gene Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes. Indicus|evm.model.PRDE01122050.1.1 Q45670 THES_BACSJ 59.322 0.54717 0.264339 Thermophilic serine proteinase precursor - Bacillus sp. (strain AK1) Indicus|evm.model.PRDE01122114.1.1 Q8A0U0 GCH1_BACTN 83.562 0.966667 0.765306 folE - GTP cyclohydrolase 1 - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - folE gene cytoplasm, GTP binding, GTP cyclohydrolase I activity, zinc ion binding, tetrahydrobiopterin biosynthetic process Indicus|evm.model.PRDE01122228.1.1 Q9ZM87 FTSK_HELPJ 54.255 0.96875 0.113744 ftsK - DNA translocase FtsK - Helicobacter pylori (strain J99 / ATCC 700824) - ftsK gene Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity). Indicus|evm.model.PRDE01122333.1.1 P0AGH0 TLDD_SHIFL 74.324 0.967105 0.316008 tldD - Metalloprotease TldD homolog - Shigella flexneri - tldD gene Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA) (By similarity). Indicus|evm.model.PRDE01122510.1.1 A5FHV7 TRMD_FLAJ1 66.337 0.934579 0.473451 trmD - tRNA (guanine-N(1)-)-methyltransferase - Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101) - trmD gene Specifically methylates guanosine-37 in various tRNAs. Indicus|evm.model.PRDE01122646.1.1 Q73M28 VATA_TREDE 65.693 0.985507 0.234295 atpA - V-type ATP synthase alpha chain - Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) - atpA gene Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Indicus|evm.model.PRDE01122661.1.1 A8MEG5 GCSH_ALKOO 62.712 0.92126 1 gcvH - Glycine cleavage system H protein - Alkaliphilus oremlandii (strain OhILAs) - gcvH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. Indicus|evm.model.PRDE01123222.1.1 Q1RIP8 UVRD_RICBR 62.609 0.961702 0.359877 uvrD - Probable DNA helicase II homolog - Rickettsia bellii (strain RML369-C) - uvrD gene Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity). Indicus|evm.model.PRDE01123527.1.1 P42257 PILJ_PSEAE 66.667 0.98 0.146628 pilJ - Protein PilJ - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pilJ gene May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). Indicus|evm.model.PRDE01123605.1.1 P0A3U1 LTRA_LACLM 45.455 0.367232 0.295492 ltrA - Group II intron-encoded protein LtrA - Lactococcus lactis subsp. cremoris (strain MG1363) - ltrA gene Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities: reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site-specific cleavage of recipient alleles. The intron-encoded protein promotes splicing by facilitating the formation of the catalytically active structure of the intron RNA. After splicing, the protein remains bound to the excised intron lariat RNA, forming ribonucleoprotein particles, and cleaving the antisense strand of the recipient DNA in the 3' exon. After DNA cleavage, retrohoming occurs by a target DNA-primed reverse transcription of the intron RNA that had reverse spliced into the sense strand of the recipient DNA. It also contributes to the recognition of the DNA target site and acts as a repressor of its own translation. Indicus|evm.model.PRDE01123741.1.1 Q9RX08 DPO3A_DEIRA 49.673 0.95 0.11985 dnaE - DNA polymerase III subunit alpha - Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) - dnaE gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative DNA synthesis in bacteria as well as the bulk of DNA synthesis/repair after ionizing radiation (IR) (PubMed:19303848). The alpha chain is the catalytic subunit (PubMed:19303848). Following severe irradiation (7 kGy of gamma irradiation) genomic DNA is fragmented. DNA is progressively degraded for the first 1.5 hours after IR, in a step promoted by RecA and counterbalanced by DNA Pol I and Pol III, followed by massive DNA synthesis and genome reassembly in the next hour. Optimal priming of DNA synthesis requires both RecA and RadA, Pol III initiates DNA synthesis while both Pol I and Pol III are required for its contination (PubMed:19303848). This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity). Indicus|evm.model.PRDE01123804.1.1 Q895J7 RBFA_CLOTE 47.458 0.913386 1.04959 rbfA - Ribosome-binding factor A - Clostridium tetani (strain Massachusetts / E88) - rbfA gene One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. Indicus|evm.model.PRDE01123918.1.1 Q14LB9 PNP_SPICI 53.383 0.992481 0.189459 pnp - Polyribonucleotide nucleotidyltransferase - Spiroplasma citri - pnp gene Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Indicus|evm.model.PRDE01124154.1.1 Q8PHB6 Y3343_XANAC 67.391 0.985612 0.776536 XAC3343 - Macro domain-containing protein XAC3343 - Xanthomonas axonopodis pv. citri (strain 306) - XAC3343 gene Indicus|evm.model.PRDE01124540.1.1 Q97FZ9 RUBY1_CLOAB 56.522 0.971429 0.358974 rbr1 - Rubrerythrin-1 - Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) - rbr1 gene Functions as the terminal component of an NADH peroxidase (NADH:H(2)O(2) oxidoreductase) when using NADH:rubredoxin oxidoreductase (NROR) as the electron transport intermediary from NADH to RubY. Indicus|evm.model.PRDE01124766.1.1 Q9AAA6 LSPA_CAUVC 48.810 0.937143 1.04167 lspA - Lipoprotein signal peptidase - Caulobacter vibrioides (strain ATCC 19089 / CB15) - lspA gene This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Indicus|evm.model.PRDE01125008.1.1 Q8PCQ7 PUR4_XANCP 71.856 0.924855 0.128338 purL - Phosphoribosylformylglycinamidine synthase - Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) - purL gene Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. Indicus|evm.model.PRDE01125088.1.1 Q89ZK5 RLMN_BACTN 64.286 0.957672 0.547826 rlmN - Probable dual-specificity RNA methyltransferase RlmN - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - rlmN gene Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. Indicus|evm.model.PRDE01125209.1.1 B0V9P2 UREG_ACIBY 82.787 0.883212 0.671569 ureG - Urease accessory protein UreG - Acinetobacter baumannii (strain AYE) - ureG gene Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG. Indicus|evm.model.PRDE01125251.1.1 B2RJX3 PTP_PORG3 52.632 0.979167 0.131148 ptpA - Prolyl tripeptidyl peptidase precursor - Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561) - ptpA gene Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position (By similarity). Indicus|evm.model.PRDE01125261.1.1 Q8A1G1 SUSC_BACTN 53.846 0.873786 0.102692 susC - TonB-dependent receptor SusC precursor - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - susC gene Mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation. Indicus|evm.model.PRDE01125278.1.1 P78283 SECY_VIBCH 66.102 0.42963 0.304054 secY - Protein translocase subunit SecY - Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) - secY gene The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. Indicus|evm.model.PRDE01125303.1.1 Q8CAY6 THIC_MOUSE 54.717 0.954545 0.277078 Acat2 - Acetyl-CoA acetyltransferase, cytosolic - Mus musculus (Mouse) - Acat2 gene Involved in the biosynthetic pathway of cholesterol. Indicus|evm.model.PRDE01125347.1.1 Q9HWC4 NUSG_PSEAE 68.966 0.97191 1.00565 nusG - Transcription termination/antitermination protein NusG - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - nusG gene Participates in transcription elongation, termination and antitermination. Indicus|evm.model.PRDE01125468.1.1 P48791 XYNB_PRERU 74.138 0.428571 0.416928 xynB - Beta-xylosidase - Prevotella ruminicola - xynB gene Exoxylanase capable of acting on certain xylans and xylooligosaccharides. Indicus|evm.model.PRDE01125509.1.1 Q59050 Y1656_METJA 57.812 0.759036 0.350211 MJ1656 - Uncharacterized protein MJ1656 - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) - MJ1656 gene hydro-lyase activity Indicus|evm.model.PRDE01125573.1.1 Q8AB57 Y254_BACTN 71.795 0.991453 0.18871 BT_0254 - UPF0313 protein BT_0254 - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - BT_0254 gene Indicus|evm.model.PRDE01125621.1.1 Q1QDJ5 GATB_PSYCK 72.727 0.721854 0.29666 gatB - Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B - Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5) - gatB gene Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Indicus|evm.model.PRDE01125800.1.1 B7NQ04 PYRE_ECO7I 78.495 0.968421 0.446009 pyrE - Orotate phosphoribosyltransferase - Escherichia coli O7:K1 (strain IAI39 / ExPEC) - pyrE gene Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). Indicus|evm.model.PRDE01125873.1.1 Q54JP5 OAT_DICDI 60.843 0.993976 0.399038 oatA - Probable ornithine aminotransferase - Dictyostelium discoideum (Slime mold) - oatA gene cytoplasm, identical protein binding, ornithine-oxo-acid transaminase activity, pyridoxal phosphate binding, arginine catabolic process to glutamate, arginine catabolic process to proline via ornithine, ornithine metabolic process Indicus|evm.model.PRDE01125982.1.1 P64612 ZAPE_ECOLI 47.368 0.862385 0.290667 zapE - Cell division protein ZapE - Escherichia coli (strain K12) - zapE gene Reduces the stability of FtsZ polymers in the presence of ATP. Required for cell division under low-oxygen conditions. Hydrolyzes ATP but not GTP. Indicus|evm.model.PRDE01125990.1.1 A7HZ77 Y3612_PARL1 57.009 0.875 0.609137 Plav_3612 - Putative NADH dehydrogenase/NAD(P)H nitroreductase Plav_3612 - Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) - Plav_3612 gene Indicus|evm.model.PRDE01126006.1.1 P17869 RPSH_BACSU 71.200 0.925373 0.614679 sigH - RNA polymerase sigma-H factor - Bacillus subtilis (strain 168) - sigH gene Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. This sigma factor is involved in the transition to post-exponential phase in the beginning of sporulation. It is also required for transcription of several stationary phase genes. Association with the RNAP core increases rapidly in early exponential phase, and reamins constant expression level after (PubMed:21710567). Indicus|evm.model.PRDE01126333.1.1 Q8GDP4 HISX_HELMO 61.157 0.930233 0.302817 hisD - Histidinol dehydrogenase - Heliobacillus mobilis - hisD gene Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. Indicus|evm.model.PRDE01126569.1.1 Q1QNQ1 FENR_NITHX 64.179 0.977941 0.397661 Nham_1321 - Ferredoxin--NADP reductase - Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14) - Nham_1321 gene Indicus|evm.model.PRDE01126577.1.1 Q8A1E8 PROA_BACTN 74.453 0.944444 0.345324 proA - Gamma-glutamyl phosphate reductase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - proA gene Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Indicus|evm.model.PRDE01126629.1.1 P67277 RNY_STAAM 57.937 0.992063 0.242775 rny - Ribonuclease Y - Staphylococcus aureus (strain Mu50 / ATCC 700699) - rny gene Endoribonuclease that initiates mRNA decay. Indicus|evm.model.PRDE01126692.1.1 P0C5S3 ACTR_RHIME 50.515 0.932039 0.530928 actR - Acid tolerance regulatory protein ActR - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - actR gene Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response (By similarity). Indicus|evm.model.PRDE01126874.1.1 Q5E5I1 HMUV_ALIF1 47.863 0.82963 0.521236 hmuV - Hemin import ATP-binding protein HmuV - Aliivibrio fischeri (strain ATCC 700601 / ES114) - hmuV gene Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01126971.1.1 A1B373 SYR_PARDP 85.849 0.990566 0.182444 argS - Arginine--tRNA ligase - Paracoccus denitrificans (strain Pd 1222) - argS gene Indicus|evm.model.PRDE01127093.1.1 Q6F6Y2 HPXO_ACIAD 80.899 0.988827 0.464935 hpxO - FAD-dependent urate hydroxylase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - hpxO gene Catalyzes the hydroxylation of urate to 5-hydroxyisourate (HIU). Is involved in the urate degradation pathway to allantoin. Indicus|evm.model.PRDE01127093.1.2 Q9HUU7 MDDA_PSEAE 45.087 0.955556 1.04651 pitA - L-methionine sulfoximine/L-methionine sulfone acetyltransferase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - pitA gene Plays a role in the resistance against the toxic effects of L-methionine sulfoximine (MSX), a rare amino acid, which inhibits glutamine synthetase (GlnA). Catalyzes the acetylation of L-methionine sulfoximine (MSX). Indicus|evm.model.PRDE01127201.1.1 B8GWS6 DPO3A_CAUVN 76.316 0.993421 0.132983 dnaE1 - DNA polymerase III subunit alpha - Caulobacter vibrioides (strain NA1000 / CB15N) - dnaE1 gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase. Indicus|evm.model.PRDE01127216.1.1 Q7MNF8 HSCA_VIBVY 49.587 0.700599 0.270665 hscA - Chaperone protein HscA homolog - Vibrio vulnificus (strain YJ016) - hscA gene Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Indicus|evm.model.PRDE01127244.1.1 B0V4R4 LGT_ACIBY 83.146 0.988636 0.323529 lgt - Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase - Acinetobacter baumannii (strain AYE) - lgt gene Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins. Indicus|evm.model.PRDE01127336.1.1 Q57256 Y522_HAEIN 47.328 0.928571 0.642202 HI_0522 - Uncharacterized protein HI_0522 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_0522 gene Indicus|evm.model.PRDE01127393.1.1 Q7MU42 TSAD_PORGI 64.103 0.97479 0.348974 tsaD - tRNA N6-adenosine threonylcarbamoyltransferase - Porphyromonas gingivalis (strain ATCC BAA-308 / W83) - tsaD gene Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. Indicus|evm.model.PRDE01127508.1.1 A9KNJ3 PYRB_LACP7 76.344 0.989247 0.302932 pyrB - Aspartate carbamoyltransferase - Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) - pyrB gene Indicus|evm.model.PRDE01127529.1.1 Q8P1N2 ADCA_STRP8 52.564 0.895349 0.16699 adcA - Zinc-binding protein AdcA precursor - Streptococcus pyogenes serotype M18 (strain MGAS8232) - adcA gene Part of the ATP-driven transport system AdcABC for zinc. Indicus|evm.model.PRDE01127567.1.1 Q5KVC6 HISX_GEOKA 54.167 0.979167 0.226415 hisD - Histidinol dehydrogenase - Geobacillus kaustophilus (strain HTA426) - hisD gene Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. Indicus|evm.model.PRDE01127568.1.1 P24136 OPPD_BACSU 73.333 0.993243 0.413408 oppD - Oligopeptide transport ATP-binding protein OppD - Bacillus subtilis (strain 168) - oppD gene Part of the binding protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system. Required for sporulation and competence. Indicus|evm.model.PRDE01127588.1.1 A6L1P5 ISPH_BACV8 69.853 0.992188 0.444444 ispH - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - ispH gene Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Indicus|evm.model.PRDE01127770.1.1 P44446 LCFH_HAEIN 55.479 0.97973 0.243822 HI_0002 - Putative long-chain-fatty-acid--CoA ligase - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_0002 gene CoA-ligase activity Indicus|evm.model.PRDE01127831.1.1 A5CRB9 LEU1_CLAM3 82.857 0.732394 0.241497 leuA - 2-isopropylmalate synthase - Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382) - leuA gene Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Indicus|evm.model.PRDE01127848.1.1 Q1RGZ5 DSB_RICBR 53.333 0.260355 0.65251 RBE_1288 - Putative protein-disulfide oxidoreductase RBE_1288 precursor - Rickettsia bellii (strain RML369-C) - RBE_1288 gene May be required for disulfide bond formation in some proteins. Indicus|evm.model.PRDE01127862.1.1 P37105 SRP54_BACSU 51.111 0.885906 0.334081 ffh - Signal recognition particle protein - Bacillus subtilis (strain 168) - ffh gene Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components (Probable). Indicus|evm.model.PRDE01128007.1.1 P90597 DLDH_TRYCR 73.214 0.947368 0.119497 LPD - Dihydrolipoyl dehydrogenase - Trypanosoma cruzi - LPD gene Indicus|evm.model.PRDE01128102.1.1 Q48412 ROMA_KLEPN 52.809 0.642336 1.03788 romA - Outer membrane protein RomA - Klebsiella pneumoniae - romA gene Indicus|evm.model.PRDE01128253.1.1 Q7WKD5 SYI_BORBR 74.286 0.852459 0.128017 ileS - Isoleucine--tRNA ligase - Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) - ileS gene Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Indicus|evm.model.PRDE01128922.1.1 P96169 SGLT_VIBPH 56.338 0.625 0.206262 sglT - Sodium/glucose cotransporter - Vibrio parahaemolyticus - sglT gene Actively transports glucose into cells by Na(+) cotransport. Indicus|evm.model.PRDE01129000.1.1 A6KZM1 MUTS_BACV8 74.194 0.987179 0.17931 mutS - DNA mismatch repair protein MutS - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - mutS gene This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. Indicus|evm.model.PRDE01129005.1.1 B0VDF1 THIC_ACIBY 92.754 0.992754 0.2208 thiC - Phosphomethylpyrimidine synthase - Acinetobacter baumannii (strain AYE) - thiC gene Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Indicus|evm.model.PRDE01129203.1.1 P08634 NODN_RHILV 46.043 0.870968 0.962733 nodN - Nodulation protein N - Rhizobium leguminosarum bv. viciae - nodN gene Involved in the production of the root hair deformation (HAD) factor specifically on medicago. Indicus|evm.model.PRDE01130009.1.1 Q0TM79 CARB_CLOP1 66.434 0.993007 0.134021 carB - Carbamoyl-phosphate synthase large chain - Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) - carB gene Indicus|evm.model.PRDE01130465.1.1 O07380 DTPT_LACHE 45.161 0.654676 0.279678 dtpT - Di-/tripeptide transporter - Lactobacillus helveticus - dtpT gene Proton-dependent uptake of di- or tri-peptides. Indicus|evm.model.PRDE01130718.1.1 Q73P70 OTCC_TREDE 71.579 0.94 0.295858 arcB - Ornithine carbamoyltransferase, catabolic - Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) - arcB gene Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. Indicus|evm.model.PRDE01130723.1.1 A6L3Y9 RS16_BACV8 62.295 0.555556 0.590164 rpsP - 30S ribosomal protein S16 - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - rpsP gene Indicus|evm.model.PRDE01130871.1.1 Q1GRH5 LEPA_SPHAL 85.000 0.99 0.164745 lepA - Elongation factor 4 - Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) - lepA gene Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. Indicus|evm.model.PRDE01131356.1.1 Q59677 MUTB_PORGI 67.442 0.84 0.0699301 mutB - Methylmalonyl-CoA mutase large subunit - Porphyromonas gingivalis (strain ATCC BAA-308 / W83) - mutB gene Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. Indicus|evm.model.PRDE01131439.1.1 O31834 YOZG_BACSU 64.286 0.945205 0.869048 yozG - Uncharacterized HTH-type transcriptional regulator YozG - Bacillus subtilis (strain 168) - yozG gene Indicus|evm.model.PRDE01131541.1.1 B2HUJ5 DNLJ_ACIBC 89.062 0.940299 0.0995542 ligA - DNA ligase - Acinetobacter baumannii (strain ACICU) - ligA gene DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. Indicus|evm.model.PRDE01131718.1.1 P42505 HVRA_RHOCA 46.154 0.947368 0.931373 hvrA - Trans-acting regulatory protein HvrA - Rhodobacter capsulatus - hvrA gene A dim-light trans-acting activator of Puf and Puh expression, that has no effect on the expression of the Puc operon. Responsible for regulating light-harvesting-I and reaction center structural gene expression differentially from that of light-harvesting-II expression in response to alterations in light. Proper light regulation of light-harvesting and reaction center polypeptide synthesis is an important physiological trait that enables cells to adapt to ever-changing environmental conditions of light intensity. Indicus|evm.model.PRDE01131728.1.1 Q5LGK5 RLMN_BACFN 56.897 0.97006 0.485465 rlmN - Probable dual-specificity RNA methyltransferase RlmN - Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) - rlmN gene Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. Indicus|evm.model.PRDE01132138.1.1 A0LZ51 PIMT_GRAFK 46.491 0.949153 0.553991 pcm - Protein-L-isoaspartate O-methyltransferase - Gramella forsetii (strain KT0803) - pcm gene Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Indicus|evm.model.PRDE01132141.1.1 G9EZR6 FLDH_CLOS3 48.667 0.925466 0.486405 fldH - Phenyllactate dehydrogenase - Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679) - fldH gene Involved in the fermentation of L-phenylalanine via a Stickland reaction. Catalyzes the reduction of phenylpyruvate to yield (R)-phenyllactate. Indicus|evm.model.PRDE01132288.1.1 Q60350 Y035_METJA 53.012 0.740741 0.432 MJ0035 - Uncharacterized ABC transporter ATP-binding protein MJ0035 - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) - MJ0035 gene Indicus|evm.model.PRDE01132350.1.1 P71353 Y568_HAEIN 76.923 0.41129 0.16273 HI_0568 - Uncharacterized protein HI_0568 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_0568 gene cytosol, mRNA binding, structural constituent of ribosome, translation Indicus|evm.model.PRDE01132403.1.1 Q03845 FLHA_CAUVC 84.783 0.412844 0.155714 flhA - Flagellar biosynthesis protein FlhA - Caulobacter vibrioides (strain ATCC 19089 / CB15) - flhA gene Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin (By similarity). Indicus|evm.model.PRDE01132661.1.1 Q48761 RADA_LISMO 49.194 0.87234 0.308534 radA - DNA repair protein RadA - Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) - radA gene DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. Indicus|evm.model.PRDE01133587.1.1 Q48230 BCS1_HAEIF 59.091 0.963235 0.28692 bcs1 - Bifunctional ribulose 5-phosphate reductase/CDP-ribitol pyrophosphorylase Bcs1 - Haemophilus influenzae - bcs1 gene Catalyzes the NADPH-dependent reduction of D-ribulose 5-phosphate to D-ribitol 5-phosphate and the further reaction of D-ribitol 5-phosphate with CTP to form CDP-ribitol. Indicus|evm.model.PRDE01133646.1.1 P10478 XYNZ_HUNT2 53.509 0.933884 0.144564 xynZ - Endo-1,4-beta-xylanase Z precursor - Hungateiclostridium thermocellum (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) - xynZ gene endo-1,4-beta-xylanase activity, xylan endo-1,3-beta-xylosidase activity Indicus|evm.model.PRDE01133891.1.1 Q2RGY5 GATB_MOOTA 60.366 0.993902 0.344538 gatB - Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B - Moorella thermoacetica (strain ATCC 39073 / JCM 9320) - gatB gene Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Indicus|evm.model.PRDE01133924.1.1 Q8Z6F3 SPPA_SALTI 56.061 0.474453 0.221683 sppA - Protease 4 - Salmonella typhi - sppA gene Digests cleaved signal peptides in vitro, its in vivo function is unknown. This activity is necessary to maintain proper secretion of mature proteins across the membrane (By similarity). Indicus|evm.model.PRDE01134064.1.1 A6VU13 RF3_MARMS 46.774 0.938931 0.248106 prfC - Peptide chain release factor 3 - Marinomonas sp. (strain MWYL1) - prfC gene Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Indicus|evm.model.PRDE01134357.1.1 P32967 GACA_PSEPH 58.511 0.484375 0.901408 gacA - Response regulator GacA - Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CHA0) - gacA gene Member of the two-component regulatory system GacA/GacS which controls the expression of secondary metabolites and extracellular products. Acts (probably primarily) by activating expression of CsrA1 and CsrA2 antagonist small RNAs (sRNA) RsmX, RsmY and RsmZ which bind to and prevent translation repression by CsrA1 and CsrA2 (PubMed:11807065, PubMed:14622422, PubMed:15601712, PubMed:16286659). Involved in the regulation of secondary metabolism and in the synthesis of the antifungal factors cyanide, 2,4-diacetylphloroglucinol and pyoluteorin (PubMed:1311842). Involved in synthesis of the autoinducing signal (unrelated to N-acylhomoserine lactones, induces the Gac/Csr cascade) (PubMed:16286659). Exercises positive post-transcriptional control over the hcnABC and aprA genes; acts upstream of CsrA2 (rsmA) (PubMed:10570200). Controls expression of csrA1 (rsmE) and csrA2 (PubMed:15601712). Indicus|evm.model.PRDE01134576.1.1 A4WG45 BTUB_ENT38 50.820 0.670455 0.143089 btuB - Vitamin B12 transporter BtuB precursor - Enterobacter sp. (strain 638) - btuB gene Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Indicus|evm.model.PRDE01134888.1.1 Q8R9C7 SYFB_CALS4 58.667 0.948718 0.0982368 pheT - Phenylalanine--tRNA ligase beta subunit - Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) - pheT gene Indicus|evm.model.PRDE01135135.1.1 P20054 PYR1_DICDI 77.778 0.946903 0.0507865 pyr1-3 - Protein PYR1-3 - Dictyostelium discoideum (Slime mold) - pyr1-3 gene This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). Indicus|evm.model.PRDE01135446.1.1 P32122 ARRH_LOCMI 84.524 0.97619 0.206388 Arrestin homolog - Locusta migratoria (Migratory locust) Indicus|evm.model.PRDE01135558.1.1 A5WG72 GCSH_PSYWF 73.171 0.96063 1.00794 gcvH - Glycine cleavage system H protein - Psychrobacter sp. (strain PRwf-1) - gcvH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. Indicus|evm.model.PRDE01135574.1.1 Q4KIX5 PUR9_PSEF5 89.630 0.985294 0.254206 purH - Bifunctional purine biosynthesis protein PurH - Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) - purH gene Indicus|evm.model.PRDE01135582.1.1 Q04810 DPAB_BACSU 46.154 0.97479 0.595 dpaB - Dipicolinate synthase subunit B - Bacillus subtilis (strain 168) - dpaB gene Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA), which constitutes up to 10% of the dry weight of the spore. Indicus|evm.model.PRDE01135674.1.1 P9WNZ3 DESA3_MYCTU 61.739 0.940678 0.276347 desA3 - NADPH-dependent stearoyl-CoA 9-desaturase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - desA3 gene Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. Indicus|evm.model.PRDE01136046.1.1 A5FMI1 SYY_FLAJ1 48.168 0.984293 0.443155 tyrS - Tyrosine--tRNA ligase - Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101) - tyrS gene Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Indicus|evm.model.PRDE01136322.1.1 P9WMN7 MOEZ_MYCTU 64.583 0.931373 0.260204 moeZ - Probable adenylyltransferase/sulfurtransferase MoeZ - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - moeZ gene Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps: first, ATP-dependent activation of CysO as acyl-adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO-thiocarboxylate (CysO-COSH) (Probable). The sulfur source is unknown. Indicus|evm.model.PRDE01136717.1.1 P9WG49 TOP1_MYCTU 70.000 0.793103 0.155246 topA - DNA topoisomerase 1 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - topA gene Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex (PubMed:8921893, PubMed:20724443). Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Indicus|evm.model.PRDE01136770.1.1 P9WMQ7 RECG_MYCTU 49.351 0.847458 0.240163 recG - ATP-dependent DNA helicase RecG - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - recG gene Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) (By similarity). Indicus|evm.model.PRDE01136791.1.1 Q934G0 LUH_PSESP 48.276 0.606383 0.135252 luh - Lupanine 17-hydroxylase [cytochrome c] precursor - Pseudomonas sp. - luh gene Catalyzes the first reaction in the catabolism of the alkaloid lupanine. It dehydrogenates lupanine, which can then be hydrated to produce 17-hydroxylupanine. Indicus|evm.model.PRDE01136852.1.1 B0T101 SYC_CAUSK 58.095 0.945455 0.238095 cysS - Cysteine--tRNA ligase - Caulobacter sp. (strain K31) - cysS gene Indicus|evm.model.PRDE01136923.1.1 Q9I6M4 DAVT_PSEAE 47.333 0.924528 0.373239 davT - 5-aminovalerate aminotransferase DavT - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - davT gene Catalyzes the conversion of 5-aminovalerate to 5-oxopentanoate. Indicus|evm.model.PRDE01137472.1.1 A6M1P8 GAL1_CLOB8 65.116 0.895105 0.367609 galK - Galactokinase - Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) - galK gene Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Indicus|evm.model.PRDE01138187.1.1 P0ABV1 TOLQ_SHIFL 70.909 0.981818 0.23913 tolQ - Tol-Pal system protein TolQ - Shigella flexneri - tolQ gene Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. Indicus|evm.model.PRDE01138605.1.1 Q9HT25 GLMS_PSEAE 70.526 0.979167 0.157119 glmS - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - glmS gene Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Indicus|evm.model.PRDE01139059.1.1 Q8A9K9 SYI_BACTN 52.055 0.945946 0.0636833 ileS - Isoleucine--tRNA ligase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - ileS gene Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Indicus|evm.model.PRDE01139197.1.1 Q64XV7 PUR7_BACFR 76.804 0.989691 0.617834 purC - Phosphoribosylaminoimidazole-succinocarboxamide synthase - Bacteroides fragilis (strain YCH46) - purC gene Indicus|evm.model.PRDE01139316.1.1 A7I6C5 DADD_METB6 64.384 0.637168 0.255656 dadD - 5'-deoxyadenosine deaminase - Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8) - dadD gene Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Indicus|evm.model.PRDE01139381.1.1 P22106 ASNB_ECOLI 66.917 0.992481 0.240072 asnB - Asparagine synthetase B [glutamine-hydrolyzing] - Escherichia coli (strain K12) - asnB gene Catalyzes the ATP-dependent conversion of aspartate into asparagine, using glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro, albeit with lower efficiency. As nucleotide substrates, ATP and dATP are utilized at a similar rate in both the glutamine- and ammonia-dependent reactions, whereas GTP utilization is only 15% that of ATP, and CTP, UTP, ITP and XTP are very poor or not substrates. Also exhibits glutaminase activity. Indicus|evm.model.PRDE01139421.1.1 Q9FC99 PFKA3_STRCO 52.083 0.647887 0.208211 pfkA3 - ATP-dependent 6-phosphofructokinase 3 - Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) - pfkA3 gene Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Indicus|evm.model.PRDE01139515.1.1 A6KZJ2 MIAB_BACV8 56.122 0.979592 0.214912 miaB - tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - miaB gene Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. Indicus|evm.model.PRDE01139778.1.1 Q03A83 TARI_LACP3 51.351 0.990991 0.474359 tarI - Ribitol-5-phosphate cytidylyltransferase - Lactobacillus paracasei (strain ATCC 334 / BCRC 17002 / CIP 107868 / KCTC 3260 / NRRL B-441) - tarI gene Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate. Indicus|evm.model.PRDE01139950.1.1 P00582 DPO1_ECOLI 53.216 0.994152 0.184267 polA - DNA polymerase I - Escherichia coli (strain K12) - polA gene In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template. Indicus|evm.model.PRDE01140170.1.1 F4G4E2 QUEG_ALIDK 68.354 0.448276 0.483333 queG - Epoxyqueuosine reductase - Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K601) - queG gene Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). Indicus|evm.model.PRDE01140237.1.1 B8I304 DNAJ_RUMCH 56.061 0.970149 0.176781 dnaJ - Chaperone protein DnaJ - Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) - dnaJ gene Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins. Indicus|evm.model.PRDE01140718.1.1 Q9K5N0 SOJ_BACHD 54.808 0.953917 0.857708 soj - Sporulation initiation inhibitor protein Soj - Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) - soj gene Inhibits the initiation of sporulation, Spo0J antagonizes this inhibition. Soj ultimately inhibits the activation (phosphorylation) of Spo0A. It is not required for chromosome partitioning (By similarity). Indicus|evm.model.PRDE01140902.1.1 Q8L7W8 FUCO2_ARATH 47.525 0.792 0.14828 FUC95A - Alpha-L-fucosidase 2 precursor - Arabidopsis thaliana (Mouse-ear cress) - FUC95A gene Hydrolyzes alpha-1,2-linked fucose. Also active on fucosylated xyloglucan oligosaccharides. No activity with 3-fucosyllactose, p-nitrophenyl-alpha-I-fucopyranoside, lacto-N-fucopentaose II, lacto-N-fucopentaose III or alpha 1,6-fucosylated chitopentaose. Involved in apoplastic xyloglucan metabolism. Indicus|evm.model.PRDE01141141.1.1 O51066 PARC_BORBU 53.608 0.96 0.159744 parC - DNA topoisomerase 4 subunit A - Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) - parC gene Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity). Indicus|evm.model.PRDE01142264.1.1 O34580 PCRA_BACSU 50.459 0.990826 0.147497 pcrA - ATP-dependent DNA helicase PcrA - Bacillus subtilis (strain 168) - pcrA gene DNA helicase used for plasmid rolling-circle replication and also involved in UV repair. Indicus|evm.model.PRDE01142409.1.1 Q8A258 MURG_BACTN 67.857 0.965035 0.384409 murG - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - murG gene Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). Indicus|evm.model.PRDE01142417.1.1 Q650H5 MNMG_BACFR 59.836 0.991736 0.1936 mnmG - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG - Bacteroides fragilis (strain YCH46) - mnmG gene NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Indicus|evm.model.PRDE01143014.1.1 A6L1I4 PYRH_BACV8 76.636 0.972477 0.461864 pyrH - Uridylate kinase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - pyrH gene Catalyzes the reversible phosphorylation of UMP to UDP. Indicus|evm.model.PRDE01145053.1.1 P38942 CAT2_CLOK5 48.936 0.951724 0.337995 cat2 - 4-hydroxybutyrate coenzyme A transferase - Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) - cat2 gene Indicus|evm.model.PRDE01145609.1.1 P46835 DPO1_MYCLE 49.333 0.925 0.0878156 polA - DNA polymerase I - Mycobacterium leprae (strain TN) - polA gene In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. Indicus|evm.model.PRDE01145975.1.1 Q89ZM4 SYV_BACTN 58.108 0.993151 0.166098 valS - Valine--tRNA ligase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - valS gene Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner. Indicus|evm.model.PRDE01146123.1.1 P54744 PKNB_MYCLE 66.667 0.992424 0.212219 pknB - Serine/threonine-protein kinase PknB - Mycobacterium leprae (strain TN) - pknB gene Protein kinase that regulates many aspects of mycobacterial physiology. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins. Indicus|evm.model.PRDE01146706.1.1 Q7VUQ1 MURD_BORPE 68.696 0.919355 0.243137 murD - UDP-N-acetylmuramoylalanine--D-glutamate ligase - Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) - murD gene Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Indicus|evm.model.PRDE01147722.1.1 Q7WSY8 CLPB_PROFC 47.222 0.922414 0.133949 clpB - Chaperone protein ClpB - Propionibacterium freudenreichii subsp. shermanii (strain ATCC 9614 / DSM 4902 / CIP 103027 / NCIMB 8099 / CIRM-BIA1) - clpB gene Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Indicus|evm.model.PRDE01151076.1.1 Q6FZB7 RS12_BARQU 78.740 0.984375 1.04065 rpsL - 30S ribosomal protein S12 - Bartonella quintana (strain Toulouse) - rpsL gene With S4 and S5 plays an important role in translational accuracy. Indicus|evm.model.PRDE01155429.1.1 P45021 CYOA_HAEIN 66.279 0.965909 0.168906 HI_1076 - Probable cytochrome oxidase subunit 1 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_1076 gene Probable cytochrome oxidase subunit. Indicus|evm.model.PRDE01157590.1.1 B7GHE3 AROQ_ANOFW 60.584 0.931507 0.986486 aroQ - 3-dehydroquinate dehydratase - Anoxybacillus flavithermus (strain DSM 21510 / WK1) - aroQ gene Catalyzes a trans-dehydration via an enolate intermediate. Indicus|evm.model.PRDE01159005.1.1 P44683 Y396_HAEIN 66.990 0.980583 0.25495 HI_0396 - Probable ribosomal oxygenase HI_0396 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_0396 gene Oxygenase that catalyzes the hydroxylation of a ribosomal protein. Indicus|evm.model.PRDE01160053.1.1 Q8W4D0 CPY71_ARATH 80.000 0.985714 0.110935 CYP71 - Peptidyl-prolyl cis-trans isomerase CYP71 - Arabidopsis thaliana (Mouse-ear cress) - CYP71 gene PPIases accelerate the folding of proteins (Probable). It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:33098102). Histone proline isomerase that increases the rate of cis-trans isomerization of the synthetic histone H3 peptides H3P30 (RKSAP30F-p-nitroanilide) and H3P30K27me3 (RKme3-SAP30F-p-nitroanilide) in the histone H3 N-terminal tail, in vitro (PubMed:33098102). Histone remodeling factor involved in chromatin-based gene silencing (PubMed:17704213). Reinforces H3K27 methylation (PubMed:17704213). Involved in fundamental processes of chromatin assembly and histone modification by mediating the targeting of FAS1 and LHP1 on the chromatin (PubMed:21596687). Required for the formation and development of leaves, for normal phyllotaxy and for the formation, maintenance and activity of root and shoot apical meristems (PubMed:17704213). Indicus|evm.model.PRDE01160303.1.1 D8K235 GYRA_DEHLB 63.158 0.831858 0.138821 gyrA - DNA gyrase subunit A - Dehalogenimonas lykanthroporepellens (strain ATCC BAA-1523 / JCM 15061 / BL-DC-9) - gyrA gene A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. Indicus|evm.model.PRDE01162577.1.1 Q8AAB1 GLMS_BACTN 73.469 0.986486 0.241042 glmS - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - glmS gene Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Indicus|evm.model.PRDE01165267.1.1 Q59735 HEMH_RHOCA 65.909 0.849673 0.435897 hemH - Ferrochelatase - Rhodobacter capsulatus - hemH gene Catalyzes the ferrous insertion into protoporphyrin IX. Indicus|evm.model.PRDE01165831.1.1 Q58836 Y1441_METJA 59.420 0.703297 0.0742251 MJ1441 - Uncharacterized protein MJ1441 - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) - MJ1441 gene Indicus|evm.model.PRDE01166288.1.1 Q816G0 G6PI_BACCR 87.912 0.989011 0.202222 pgi - Glucose-6-phosphate isomerase - Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711) - pgi gene cytosol, glucose-6-phosphate isomerase activity, monosaccharide binding, gluconeogenesis, glucose 6-phosphate metabolic process, glycolytic process Indicus|evm.model.PRDE01166599.1.1 A6L5G7 DAPA_BACV8 67.442 0.984615 0.43771 dapA - 4-hydroxy-tetrahydrodipicolinate synthase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - dapA gene Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). Indicus|evm.model.PRDE01167048.1.1 Q9PGU4 DPO3A_XYLFA 65.385 0.836957 0.0771165 dnaE - DNA polymerase III subunit alpha - Xylella fastidiosa (strain 9a5c) - dnaE gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity). Indicus|evm.model.PRDE01167291.1.1 Q59A32 PUR2_BOVIN 46.296 0.963964 0.109901 GART - Trifunctional purine biosynthetic protein adenosine-3 - Bos taurus (Bovine) - GART gene cytosol, phosphoribosylamine-glycine ligase activity, phosphoribosylformylglycinamidine cyclo-ligase activity, adenine biosynthetic process, purine nucleotide biosynthetic process Indicus|evm.model.PRDE01167665.1.1 O07631 BIPA_BACSU 75.789 0.854545 0.179739 bipA - 50S ribosomal subunit assembly factor BipA - Bacillus subtilis (strain 168) - bipA gene A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA. Indicus|evm.model.PRDE01168075.1.1 A6L5E2 TSAD_BACV8 88.235 0.923077 0.268437 tsaD - tRNA N6-adenosine threonylcarbamoyltransferase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - tsaD gene Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. Indicus|evm.model.PRDE01168498.1.1 O08340 GLTD_RHOSH 65.217 0.400881 0.549637 gltD - Putative glutamate synthase [NADPH] small chain - Rhodobacter sphaeroides - gltD gene Indicus|evm.model.PRDE01168572.1.1 P25152 BSAP_BACSU 60.714 0.982143 0.123077 ywaD - Aminopeptidase YwaD precursor - Bacillus subtilis (strain 168) - ywaD gene Catalyzes the hydrolysis of a range of N-terminal amino acids. Indicus|evm.model.PRDE01168610.1.1 P37469 DNAC_BACSU 46.286 0.988571 0.385463 dnaC - Replicative DNA helicase - Bacillus subtilis (strain 168) - dnaC gene cytosol, DNA helicase activity, DNA unwinding involved in DNA replication Indicus|evm.model.PRDE01168625.1.1 A0KQA5 RPOB_AERHH 100.000 0.991071 0.0834575 rpoB - DNA-directed RNA polymerase subunit beta - Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049) - rpoB gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01168764.1.1 P37567 DUS1_BACSU 90.984 0.991803 0.366366 dus1 - Probable tRNA-dihydrouridine synthase 1 - Bacillus subtilis (strain 168) - dus1 gene Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Indicus|evm.model.PRDE01168902.1.1 O07940 YISQ_BACSU 60.109 0.98913 0.404396 yisQ - Uncharacterized transporter YisQ - Bacillus subtilis (strain 168) - yisQ gene Indicus|evm.model.PRDE01168905.1.1 Q8Y9V5 PGDA_LISMO 50.000 0.670213 0.201717 pgdA - Peptidoglycan-N-acetylglucosamine deacetylase PgdA - Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) - pgdA gene Catalyzes the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan (PG) (By similarity). Deacetylates also N-acetylated PG (PubMed:17215377). Does not deacetylate N-acetylmuramic acid (By similarity). Confers host lysozyme resistance (PubMed:17215377, PubMed:29215169). Critical for virulence and escape from innate immune response of the host. Required for intracellular survival of bacteria in macrophages of the host (PubMed:17215377). Required for successful host colonization (PubMed:17215377, PubMed:21844299). Controls the production of inflammatory mediators in the bone marrow derived macrophages (BMMs) of the infected mouse (By similarity). Suppresses Toll-like receptor 2 (TLR2)-dependent secretion of interleukin 6 (IL-6) and interferon-beta (IFN-beta) in the macrophages of the infected mouse. May decrease accessibility of pattern recognition receptors (PRRs) such as nucleotide-binding oligomerization domain protein (NOD) 1 of the host to the bacterial cell wall components (PubMed:17215377). Protects cells from autolysis induced by lysozyme or by other autolysis-inducing agents (By similarity). Indicus|evm.model.PRDE01169461.1.1 Q9WYC5 PFP_THEMA 74.000 0.388889 0.300716 pfp - Pyrophosphate--fructose 6-phosphate 1-phosphotransferase - Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) - pfp gene Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Indicus|evm.model.PRDE01169646.1.1 A8GHY4 ISCR_SERP5 50.000 0.767857 0.341463 iscR - HTH-type transcriptional regulator IscR - Serratia proteamaculans (strain 568) - iscR gene Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Indicus|evm.model.PRDE01169646.1.2 Q3IFI3 ISCS_PSET1 67.708 0.940594 0.249383 iscS - Cysteine desulfurase IscS - Pseudoalteromonas translucida (strain TAC 125) - iscS gene Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Indicus|evm.model.PRDE01169825.1.1 A4QB76 DCUP_CORGB 80.435 0.947917 0.268156 hemE - Uroporphyrinogen decarboxylase - Corynebacterium glutamicum (strain R) - hemE gene Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. Indicus|evm.model.PRDE01169846.1.1 A6KZH6 SYL_BACV8 60.714 0.954023 0.092161 leuS - Leucine--tRNA ligase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - leuS gene Indicus|evm.model.PRDE01169937.1.1 Q11VZ3 ILVC_CYTH3 82.171 0.992248 0.262195 ilvC - Ketol-acid reductoisomerase (NADP(+)) - Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465) - ilvC gene Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. Indicus|evm.model.PRDE01170075.1.1 Q8GW72 FUCO1_ARATH 45.752 0.967949 0.3083 FUC1 - Alpha-L-fucosidase 1 precursor - Arabidopsis thaliana (Mouse-ear cress) - FUC1 gene Hydrolyzes both 3- and 4-linked fucoses in Lewis determinants. Not active on neither 2-linked fucose nor on fucose in alpha-1,3-linkage to the innermost GlcNAc. Indicus|evm.model.PRDE01170190.1.1 P12011 GNTK_BACSU 85.315 0.97931 0.282651 gntK - Gluconokinase - Bacillus subtilis (strain 168) - gntK gene Indicus|evm.model.PRDE01170406.1.1 P39592 YWBI_BACSU 49.558 0.909836 0.405316 ywbI - Uncharacterized HTH-type transcriptional regulator YwbI - Bacillus subtilis (strain 168) - ywbI gene cytosol, bacterial-type cis-regulatory region sequence-specific DNA binding, regulation of transcription, DNA-templated Indicus|evm.model.PRDE01170912.1.1 Q65IS8 PROB2_BACLD 71.648 0.992366 0.702413 proB2 - Glutamate 5-kinase 2 - Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46) - proB2 gene Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. Indicus|evm.model.PRDE01171441.1.1 P77348 MPPA_ECOLI 53.571 0.978873 0.264432 mppA - Periplasmic murein peptide-binding protein precursor - Escherichia coli (strain K12) - mppA gene Essential for the uptake of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha-linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system. Indicus|evm.model.PRDE01171907.1.1 P94550 ETFB_BACSU 71.212 0.970149 0.2607 etfB - Electron transfer flavoprotein subunit beta - Bacillus subtilis (strain 168) - etfB gene The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Indicus|evm.model.PRDE01171926.1.1 Q7XR61 MTK1_ORYSJ 77.419 0.743902 0.190698 MTK1 - Methylthioribose kinase 1 - Oryza sativa subsp. japonica (Rice) - MTK1 gene Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. Indicus|evm.model.PRDE01172032.1.1 P13511 CZCA_CUPMC 51.240 0.967742 0.116651 czcA - Cobalt-zinc-cadmium resistance protein CzcA - Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) - czcA gene Has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance. CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete CZC efflux system (CzcABC). Indicus|evm.model.PRDE01172306.1.1 O32169 METN_BACSU 68.504 0.976744 0.378299 metN - Methionine import ATP-binding protein MetN - Bacillus subtilis (strain 168) - metN gene Part of the ABC transporter complex MetNPQ involved in methionine import (PubMed:14990259). Responsible for energy coupling to the transport system (Probable). It has also been shown to be involved in methionine sulfoxide transport (PubMed:14990259). Indicus|evm.model.PRDE01172377.1.1 Q11PZ7 TPIS_CYTH3 71.000 0.942857 0.418327 tpiA - Triosephosphate isomerase - Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465) - tpiA gene Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). Indicus|evm.model.PRDE01172384.1.1 Q8L2J7 LEP_RICTY 47.573 0.961905 0.397727 lepB - Signal peptidase I - Rickettsia typhi (strain ATCC VR-144 / Wilmington) - lepB gene Complements E.coli mutants temperature-sensitive for LepB function. Indicus|evm.model.PRDE01172404.1.1 Q937N9 PRPC_CUPNE 74.180 0.991837 0.636364 prpC - 2-methylcitrate synthase - Cupriavidus necator (Alcaligenes eutrophus) - prpC gene Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower efficiency. Indicus|evm.model.PRDE01172547.1.1 Q03438 COX2_BACP3 77.143 0.896552 0.325843 ctaC - Cytochrome c oxidase subunit 2 precursor - Bacillus sp. (strain PS3) - ctaC gene Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). Indicus|evm.model.PRDE01172971.1.1 P54932 RDXB_RHOS4 75.969 0.969697 0.27673 rdxB - Protein RdxB - Rhodobacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) - rdxB gene Involved in a membrane generated redox signal; required to maintain repression of photosynthesis gene expression in the presence of oxygen. Indicus|evm.model.PRDE01173136.1.1 A5WHX7 RPPH_PSYWF 83.735 0.953757 1 rppH - RNA pyrophosphohydrolase - Psychrobacter sp. (strain PRwf-1) - rppH gene Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. Indicus|evm.model.PRDE01173564.1.1 P37551 PURR_BACSU 70.440 0.993711 0.557895 purR - Pur operon repressor - Bacillus subtilis (strain 168) - purR gene Controls the transcription of the pur operon for purine biosynthetic genes, binds to the control region of the operon. DNA binding is inhibited by 5-phosphoribosyl 1-pyrophosphate. Indicus|evm.model.PRDE01174650.1.1 Q9I6C8 CALB_PSEAE 53.143 0.910995 0.401261 calB - Probable coniferyl aldehyde dehydrogenase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - calB gene Indicus|evm.model.PRDE01175217.1.1 Q9HYT3 Y3311_PSEAE 51.020 0.857143 0.0715198 PA3311 - Uncharacterized signaling protein PA3311 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA3311 gene cyclic-guanylate-specific phosphodiesterase activity, cellular response to nitric oxide Indicus|evm.model.PRDE01175728.1.1 Q8A294 HPPA_BACTN 69.027 0.991071 0.152589 hppA - Putative K(+)-stimulated pyrophosphate-energized sodium pump - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - hppA gene Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. Indicus|evm.model.PRDE01175813.1.1 A6L078 RSMH_BACV8 53.465 0.990099 0.332237 rsmH - Ribosomal RNA small subunit methyltransferase H - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - rsmH gene Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. Indicus|evm.model.PRDE01175925.1.1 A4WX66 MOAC_RHOS5 75.000 0.858491 0.666667 moaC - Cyclic pyranopterin monophosphate synthase - Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) - moaC gene Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). Indicus|evm.model.PRDE01176013.1.1 O32050 YRBG_BACSU 51.923 0.927273 0.504587 yrbG - UPF0702 transmembrane protein YrbG - Bacillus subtilis (strain 168) - yrbG gene Indicus|evm.model.PRDE01176218.1.1 P0AE12 AMN_ECOLI 65.854 0.975904 0.171488 amn - AMP nucleosidase - Escherichia coli (strain K12) - amn gene Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. Indicus|evm.model.PRDE01176597.1.1 P71348 ALAA_HAEIN 64.885 0.977444 0.329208 alaA - Glutamate-pyruvate aminotransferase AlaA - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - alaA gene Involved in the biosynthesis of alanine. Indicus|evm.model.PRDE01176671.1.1 A0M5H8 SYK_GRAFK 88.679 0.42623 0.214411 lysS - Lysine--tRNA ligase - Gramella forsetii (strain KT0803) - lysS gene Indicus|evm.model.PRDE01176930.1.1 P9WG03 SUGA_MYCTU 44.681 0.94898 0.319218 sugA - Trehalose transport system permease protein SugA - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - sugA gene Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for the translocation of the substrate across the membrane. Indicus|evm.model.PRDE01177251.1.1 Q4FQ44 TRMD_PSYA2 76.000 0.908257 0.429134 trmD - tRNA (guanine-N(1)-)-methyltransferase - Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4) - trmD gene Specifically methylates guanosine-37 in various tRNAs. Indicus|evm.model.PRDE01177376.1.1 Q8Y653 MNTA_LISMO 56.566 0.844828 0.374194 mntA - Manganese-binding lipoprotein MntA precursor - Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) - mntA gene This protein is probably a component of a manganese permease, a binding protein-dependent, ATP-driven transport system. Indicus|evm.model.PRDE01177714.1.1 O67820 IMDH_AQUAE 58.095 0.990291 0.210204 guaB - Inosine-5'-monophosphate dehydrogenase - Aquifex aeolicus (strain VF5) - guaB gene Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Indicus|evm.model.PRDE01177736.1.1 P00902 TRPG_ACIAD 88.189 0.984375 0.659794 trpG - Anthranilate synthase component 2 - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - trpG gene Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity). Indicus|evm.model.PRDE01178280.1.1 B0SZ33 COAX_CAUSK 78.125 0.926471 0.260536 coaX - Type III pantothenate kinase - Caulobacter sp. (strain K31) - coaX gene Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Indicus|evm.model.PRDE01181176.1.1 Q54IM8 ACAD8_DICDI 53.147 0.95302 0.358173 acad8 - Isobutyryl-CoA dehydrogenase, mitochondrial precursor - Dictyostelium discoideum (Slime mold) - acad8 gene Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA. Indicus|evm.model.PRDE01181278.1.1 Q5YSB9 SYP_NOCFA 81.529 0.987342 0.270085 proS - Proline--tRNA ligase - Nocardia farcinica (strain IFM 10152) - proS gene Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS. Indicus|evm.model.PRDE01183269.1.1 Q01835 P60_LISGR 45.312 0.477273 0.258317 iap - Probable endopeptidase p60 precursor - Listeria grayi - iap gene This major extracellular protein may be involved in the invasion of non-professional phagocytic cells by Listeria. Indicus|evm.model.PRDE01185032.1.1 P50845 KDGK_BACSU 67.213 0.909091 0.203704 kdgK - 2-dehydro-3-deoxygluconokinase - Bacillus subtilis (strain 168) - kdgK gene Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). Indicus|evm.model.PRDE01185521.1.1 P07773 CATA_ACIAD 70.677 0.977778 0.434084 catA - Catechol 1,2-dioxygenase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - catA gene catechol 1,2-dioxygenase activity, ferric iron binding, catechol-containing compound catabolic process Indicus|evm.model.PRDE01185819.1.1 H9L427 BIPA_SALTY 61.688 0.987097 0.255354 bipA - 50S ribosomal subunit assembly factor BipA - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - bipA gene A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA (By similarity). A ribosome-stimulated GTPase, GTPase activity increases 4 fold in the presence of 70S ribosomes. Bind to 70S ribosomes in the presence of GTP or its non-hydrolyzable analog GMPPNP; in the presence of ppGpp or under stress conditions it binds to 30S ribosomal subunits (PubMed:18621905, PubMed:19803466). Indicus|evm.model.PRDE01185994.1.1 B8CW54 EFTS_HALOH 51.111 0.886667 0.501672 tsf - Elongation factor Ts - Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) - tsf gene Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Indicus|evm.model.PRDE01186115.1.1 Q8A602 AROC_BACTN 78.571 0.943182 0.24581 aroC - Chorismate synthase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - aroC gene Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. Indicus|evm.model.PRDE01186298.1.1 A7LXT0 GH31A_BACO1 52.222 0.831776 0.112159 BACOVA_02646 - Alpha-xylosidase BoGH31A precursor - Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / NCTC 11153) - BACOVA_02646 gene Catalyzes the liberation of alpha-xylose from the non-reducing terminal glucose of xyloglucan oligosaccharides in xyloglucan degradation, converting the 'X' to 'G' units. Indicus|evm.model.PRDE01186349.1.1 P25994 CARB_BACSU 52.778 0.922078 0.0718954 pyrAB - Carbamoyl-phosphate synthase pyrimidine-specific large chain - Bacillus subtilis (strain 168) - pyrAB gene cytoplasm, glutamine metabolic process, nitrogen compound metabolic process Indicus|evm.model.PRDE01186358.1.1 O87697 CBIG_BACME 56.579 0.513699 0.390374 cbiG - Cobalt-precorrin-5A hydrolase - Bacillus megaterium - cbiG gene Catalyzes the hydrolysis of the ring A acetate delta-lactone of cobalt-precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde. Indicus|evm.model.PRDE01186622.1.1 O51526 DPO3A_BORBU 52.273 0.84466 0.0897995 dnaE - DNA polymerase III subunit alpha - Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) - dnaE gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity). Indicus|evm.model.PRDE01186685.1.1 B1IEL7 ADDB_CLOBK 45.055 0.715447 0.106957 addB - ATP-dependent helicase/deoxyribonuclease subunit B - Clostridium botulinum (strain Okra / Type B1) - addB gene The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity. Indicus|evm.model.PRDE01186721.1.1 Q64T65 SYFB_BACFR 55.906 0.984252 0.154878 pheT - Phenylalanine--tRNA ligase beta subunit - Bacteroides fragilis (strain YCH46) - pheT gene Indicus|evm.model.PRDE01187189.1.1 P52024 HOLB_PSEAE 51.923 0.337748 0.460366 holB - DNA polymerase III subunit delta' - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - holB gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity). Indicus|evm.model.PRDE01187358.1.1 B8H621 PYRE_CAUVN 81.159 0.964789 0.731959 pyrE - Orotate phosphoribosyltransferase - Caulobacter vibrioides (strain NA1000 / CB15N) - pyrE gene Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). Indicus|evm.model.PRDE01187389.1.1 Q8G2M6 BEPE_BRUSU 49.587 0.84507 0.135109 bepE - Efflux pump membrane transporter BepE - Brucella suis biovar 1 (strain 1330) - bepE gene Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics. Indicus|evm.model.PRDE01187458.1.1 Q1QC36 URE12_PSYCK 65.116 0.994186 0.281506 ureC2 - Urease subunit alpha 2 - Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5) - ureC2 gene Indicus|evm.model.PRDE01187596.1.1 A9KMF8 RL21_LACP7 72.000 0.859649 0.558824 rplU - 50S ribosomal protein L21 - Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) - rplU gene This protein binds to 23S rRNA in the presence of protein L20. Indicus|evm.model.PRDE01188011.1.1 P0C934 DHE2_PORGI 80.000 0.988889 0.202247 gdh - NAD-specific glutamate dehydrogenase - Porphyromonas gingivalis (strain ATCC BAA-308 / W83) - gdh gene Probably involved in degradation rather than biosynthesis of glutamate. Indicus|evm.model.PRDE01188235.1.1 Q07698 ABCA_AERSA 47.788 0.948718 0.37987 abcA - ABC transporter protein AbcA - Aeromonas salmonicida - abcA gene Influences the expression of the surface array protein gene (vapA). May have both regulatory and transport activities. Indicus|evm.model.PRDE01188303.1.1 Q18990 PYR1_CAEEL 75.904 0.993976 0.0755232 pyr-1 - CAD protein - Caenorhabditis elegans - pyr-1 gene This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (By similarity). Involved in the elongation of the pharyngeal isthmus during development, probably by providing precursors of UDP-sugars required for heparan sulfate proteoglycan biosynthesis (PubMed:16828468). Regulates the organization of the actin and intermediate filaments cytoskeleton in the pharyngeal muscles (PubMed:16828468). Indicus|evm.model.PRDE01188466.1.1 Q8A294 HPPA_BACTN 75.148 0.982456 0.23297 hppA - Putative K(+)-stimulated pyrophosphate-energized sodium pump - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - hppA gene Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. Indicus|evm.model.PRDE01188570.1.1 Q9I1M1 ODBB_PSEAE 68.519 0.963964 0.317143 bkdA2 - 2-oxoisovalerate dehydrogenase subunit beta - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - bkdA2 gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Indicus|evm.model.PRDE01188668.1.1 Q8R9F9 RSMH_CALS4 66.667 0.890411 0.237013 rsmH - Ribosomal RNA small subunit methyltransferase H - Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) - rsmH gene Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. Indicus|evm.model.PRDE01188917.1.1 P80194 DPO1_THECA 51.562 0.488372 0.154676 polA - DNA polymerase I, thermostable - Thermus caldophilus - polA gene Has 5'-3' exonuclease activity and no 3'-5' exonuclease activity. Indicus|evm.model.PRDE01189253.1.1 P54163 QPTR_BACSU 52.500 0.868613 0.598253 ypdP - Probable queuosine precursor transporter - Bacillus subtilis (strain 168) - ypdP gene Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. Indicus|evm.model.PRDE01189302.1.1 A0A0R6L508 MCR1_ECOLX 52.381 0.390476 0.194085 mcr1 - Probable phosphatidylethanolamine transferase Mcr-1 - Escherichia coli - mcr1 gene Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172). Indicus|evm.model.PRDE01189409.1.1 Q2M3G0 ABCB5_HUMAN 50.000 0.869565 0.109785 ABCB5 - ATP-binding cassette sub-family B member 5 - Homo sapiens (Human) - ABCB5 gene Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:22306008, PubMed:15899824, PubMed:15205344). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity). Indicus|evm.model.PRDE01189422.1.1 Q9I4C8 Y1210_PSEAE 71.338 0.974843 0.685345 PA1210 - Putative quercetin 2,3-dioxygenase PA1210 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA1210 gene Putative quercetin 2,3-dioxygenase. Indicus|evm.model.PRDE01189589.1.1 P39342 YJGR_ECOLI 68.098 0.97006 0.334 yjgR - Uncharacterized protein YjgR - Escherichia coli (strain K12) - yjgR gene Indicus|evm.model.PRDE01190088.1.1 B6IUW0 SECA_RHOCS 62.105 0.639456 0.160131 secA - Protein translocase subunit SecA - Rhodospirillum centenum (strain ATCC 51521 / SW) - secA gene Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Indicus|evm.model.PRDE01190156.1.1 Q54KB7 DHE3_DICDI 48.780 0.89011 0.181275 gluD - Glutamate dehydrogenase, mitochondrial precursor - Dictyostelium discoideum (Slime mold) - gluD gene extracellular matrix, mitochondrion, phagocytic vesicle, glutamate dehydrogenase (NAD+) activity, glutamate dehydrogenase [NAD(P)+] activity, glutamate catabolic process Indicus|evm.model.PRDE01190187.1.1 Q4FUW9 DNLJ_PSYA2 59.155 0.990991 0.160637 ligA - DNA ligase - Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4) - ligA gene DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. Indicus|evm.model.PRDE01190464.1.1 Q59189 PARE_BORBU 64.179 0.880795 0.252087 parE - DNA topoisomerase 4 subunit B - Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) - parE gene Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity). Indicus|evm.model.PRDE01190802.1.1 Q8RHX4 KAMA_FUSNN 71.795 0.96875 0.376471 kamA - L-lysine 2,3-aminomutase - Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) - kamA gene Catalyzes the interconversion of L-alpha-lysine and L-beta-lysine. Indicus|evm.model.PRDE01190806.1.1 A2RKA6 NUPB_LACLM 47.368 0.831858 0.31044 nupB - Nucleoside ABC transporter permease protein NupB - Lactococcus lactis subsp. cremoris (strain MG1363) - nupB gene Part of an ABC transporter complex involved in the uptake of all common nucleosides (PubMed:20595258). Responsible for the translocation of the substrate across the membrane (Probable). Indicus|evm.model.PRDE01190834.1.1 B0T1I4 NRDR_CAUSK 64.238 0.936709 1.00637 nrdR - Transcriptional repressor NrdR - Caulobacter sp. (strain K31) - nrdR gene Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. Indicus|evm.model.PRDE01190977.1.1 Q8DUY4 TCMPA_STRMU 55.725 0.984848 0.487085 SMU_746c - Putative two-component membrane permease complex subunit SMU_746c - Streptococcus mutans serotype c (strain ATCC 700610 / UA159) - SMU_746c gene Could be part of a two-component membrane permease system responsible for amino acid transport under low pH. Involved in acidogenesis, biofilm formation and low-pH survival. Indicus|evm.model.PRDE01191102.1.1 Q9RQJ2 PAD_PORGI 48.718 0.962025 0.142086 PG_1424 - Peptidylarginine deiminase precursor - Porphyromonas gingivalis (strain ATCC BAA-308 / W83) - PG_1424 gene Deiminates the guanidino group of C-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. May promote the growth of the pathogen in the periodontal pocket by producing ammonia, ammonia having a protective effect during acidic cleaning cycles in the mouth. Indicus|evm.model.PRDE01191427.1.1 G8JZS4 SUSB_BACTN 46.753 0.926829 0.111111 susB - Glucan 1,4-alpha-glucosidase SusB precursor - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - susB gene Glucoamylase that hydrolyzes alpha-1,4-glucosidic linkages, alpha-1,6-, alpha-1,3- and alpha-1,2-glucosidic linkages during starch degradation. Indicus|evm.model.PRDE01191527.1.1 Q69RJ0 GLTB_ORYSJ 69.388 0.738462 0.0402477 GLU - Ferredoxin-dependent glutamate synthase, chloroplastic precursor - Oryza sativa subsp. japonica (Rice) - GLU gene Involved in glutamate biosynthesis in leaf. Required for the reassimilation of ammonium ions generated during photorespiration (By similarity). Indicus|evm.model.PRDE01191533.1.1 Q8ZAE4 WECC_YERPE 79.452 0.986301 0.17381 wecC - UDP-N-acetyl-D-mannosamine dehydrogenase - Yersinia pestis - wecC gene Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA). Indicus|evm.model.PRDE01191591.1.1 P38947 SUCD_CLOK5 49.550 0.901639 0.269316 sucD - Succinate-semialdehyde dehydrogenase (acetylating) - Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) - sucD gene Catalyzes the reduction of succinate semialdehyde to succinyl-CoA. The enzyme is specific for succinate semialdehyde and succinyl-CoA, and only shows low activity with palmitoyl-CoA. There is no activity with NAD(+) as cosubstrate. Indicus|evm.model.PRDE01191742.1.1 P43010 PNTB_HAEIN 84.000 0.993333 0.316456 pntB - NAD(P) transhydrogenase subunit beta - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - pntB gene The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. Indicus|evm.model.PRDE01191902.1.1 P51834 SMC_BACSU 54.545 0.964286 0.0472175 smc - Chromosome partition protein Smc - Bacillus subtilis (strain 168) - smc gene Required for chromosome condensation and partitioning. Indicus|evm.model.PRDE01191922.1.1 P44870 FTSY_HAEIN 56.000 0.961165 0.248792 ftsY - Signal recognition particle receptor FtsY - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - ftsY gene Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. Indicus|evm.model.PRDE01191946.1.1 Q4P902 XIN1_USTMA 43.939 0.907692 0.188953 UMAG_03411 - Endo-1,4-beta-xylanase UM03411 precursor - Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) - UMAG_03411 gene Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Indicus|evm.model.PRDE01191954.1.1 Q59754 PPDK_RHIME 60.465 0.992248 0.143653 ppdK - Pyruvate, phosphate dikinase - Rhizobium meliloti (strain 1021) (Ensifer meliloti) - ppdK gene Catalyzes the reversible phosphorylation of pyruvate and phosphate. Indicus|evm.model.PRDE01192006.1.1 Q8DRP0 RADA_STRR6 56.579 0.747475 0.235714 radA - DNA repair protein RadA - Streptococcus pneumoniae (strain ATCC BAA-255 / R6) - radA gene Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks (By similarity). Required for efficient transformation with chromosomal (linear) DNA, but not for replicative plasmid DNA. Its increased sensitivity to a DNA damaging agent suggests it may be required for DNA repair (PubMed:17631629). Indicus|evm.model.PRDE01192483.1.1 O32219 CADA_BACSU 56.322 0.977273 0.125356 cadA - Cadmium, zinc and cobalt-transporting ATPase - Bacillus subtilis (strain 168) - cadA gene Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper. Indicus|evm.model.PRDE01192794.1.1 P95544 DHE4_PRERU 47.253 0.894737 0.213964 gdhA - NAD(P)-specific glutamate dehydrogenase - Prevotella ruminicola - gdhA gene Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. P.ruminicola possess both NADP(H)- and NAD(H)-dependent activities on the same enzyme, suggesting that both anabolic and catabolic forms of the enzyme might occur. Indicus|evm.model.PRDE01192923.1.1 Q64UA3 ATPG_BACFR 62.903 0.938462 0.224138 atpG - ATP synthase gamma chain - Bacteroides fragilis (strain YCH46) - atpG gene Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. Indicus|evm.model.PRDE01192997.1.1 A0R574 CLPC1_MYCS2 91.935 0.983871 0.0731132 clpC1 - ATP-dependent Clp protease ATP-binding subunit ClpC1 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - clpC1 gene ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable). Indicus|evm.model.PRDE01193441.1.1 Q6FZX3 LOLD_BARQU 54.737 0.817391 0.50885 lolD - Lipoprotein-releasing system ATP-binding protein LolD - Bartonella quintana (strain Toulouse) - lolD gene Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. Indicus|evm.model.PRDE01193458.1.1 O32052 YRBF_BACSU 45.455 0.607477 1.20225 yrbF - Sec translocon accessory complex subunit YrbF - Bacillus subtilis (strain 168) - yrbF gene The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. Indicus|evm.model.PRDE01193585.1.1 A5WD52 CH60_PSYWF 86.364 0.992424 0.240876 groL - 60 kDa chaperonin - Psychrobacter sp. (strain PRwf-1) - groL gene Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Indicus|evm.model.PRDE01193660.1.1 A6KXU3 DDL_BACV8 59.722 0.993056 0.444444 ddl - D-alanine--D-alanine ligase - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - ddl gene Cell wall formation. Indicus|evm.model.PRDE01193813.1.1 O35005 YTRF_BACSU 54.839 0.924242 0.151376 ytrF - ABC transporter permease YtrF precursor - Bacillus subtilis (strain 168) - ytrF gene Part of the ABC transporter complex YtrBCDEF that plays a role in acetoin utilization during stationary phase and sporulation. Indicus|evm.model.PRDE01194006.1.1 A4WEU1 TDCC_ENT38 94.964 0.857143 0.363431 tdcC - Threonine/serine transporter TdcC - Enterobacter sp. (strain 638) - tdcC gene Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). Indicus|evm.model.PRDE01194158.1.1 C3J8X2 DPP5_POREA 69.128 0.986667 0.217077 dpp5 - Dipeptidyl-peptidase 5 precursor - Porphyromonas endodontalis (strain ATCC 35406 / BCRC 14492 / JCM 8526 / NCTC 13058 / HG 370) - dpp5 gene Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. Prefers Ala and hydrophobic residues at the P1 position, and has no preference for P2 residues. Shows the highest dipeptidyl peptidase activity toward the synthetic substrate Lys-Ala-methylcoumaryl-7-amide (Lys-Ala-MCA). Is likely involved in amino acid metabolism and bacterial growth/survival of asaccharolytic P.endodontalis, that utilizes amino acids from extracellular proteinaceous nutrients as energy and carbon sources. Indicus|evm.model.PRDE01194483.1.1 D5EY13 XYFA_PRER2 60.938 0.645161 0.128099 xyn10D-fae1A - Endo-1,4-beta-xylanase/feruloyl esterase precursor - Prevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23) - xyn10D-fae1A gene Involved in degradation of plant cell wall polysaccharides. Has endo-xylanase activity towards substrates such as oat spelt xylan (OSX), acetylated xylo-oligosaccharides and acetylated xylan, producing primarily xylobiose; cannot hydrolyze xylobiose to xylose. Also has feruloyl esterase activity, releasing ferulic acid from methylferulate, and from the more natural substrates wheat bran, corn fiber, and XOS(FA,Ac), a corn fiber-derived substrate enriched in O-acetyl and ferulic acid esters. Exhibits negligible acetyl esterase activity on sugar acetates. Acts synergistically with Xyl3A to increase the release of xylose from xylan. Does not possess endoglucanase or mannanase activities since it is not able to hydrolyze carboxymethyl cellulose and locust bean gum. Indicus|evm.model.PRDE01194558.1.1 P96654 YDDQ_BACSU 50.595 0.976608 0.95 yddQ - Uncharacterized isochorismatase family protein YddQ - Bacillus subtilis (strain 168) - yddQ gene Indicus|evm.model.PRDE01194633.1.1 A6L4C4 PAND_BACV8 85.227 0.956044 0.784483 panD - Aspartate 1-decarboxylase precursor - Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154) - panD gene Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. Indicus|evm.model.PRDE01195085.1.1 Q64UR4 SERC_BACFR 69.231 0.984733 0.369014 serC - Phosphoserine aminotransferase - Bacteroides fragilis (strain YCH46) - serC gene Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Indicus|evm.model.PRDE01195252.1.1 A2SKA3 Y3039_METPP 72.868 0.984615 0.802469 Mpe_A3039 - UPF0234 protein Mpe_A3039 - Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1) - Mpe_A3039 gene Indicus|evm.model.PRDE01195431.1.1 Q30WM4 BUK_DESAG 46.269 0.963235 0.365591 buk - Probable butyrate kinase - Desulfovibrio alaskensis (strain ATCC BAA 1058 / DSM 17464 / G20) - buk gene Indicus|evm.model.PRDE01195459.1.1 Q8YBN9 Y3860_BRUME 57.534 0.96 0.23511 BMEII0860 - Putative peptide permease protein BMEII0860 - Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) - BMEII0860 gene Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane (By similarity). Indicus|evm.model.PRDE01195774.1.1 A0M3M1 RECR_GRAFK 56.667 0.967391 0.44878 recR - Recombination protein RecR - Gramella forsetii (strain KT0803) - recR gene May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. Indicus|evm.model.PRDE01195802.1.1 P97478 COQ7_MOUSE 50.000 0.984496 0.59447 Coq7 - 5-demethoxyubiquinone hydroxylase, mitochondrial precursor - Mus musculus (Mouse) - Coq7 gene Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity). Involved in lifespan determination in a ubiquinone-independent manner (PubMed:19478076). Indicus|evm.model.PRDE01196115.1.1 Q9L9C1 PAAK_AROEV 46.853 0.972414 0.329545 paaK - Phenylacetate-coenzyme A ligase - Aromatoleum evansii - paaK gene Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). Involved in the phenylalanine metabolism. Indicus|evm.model.PRDE01196276.1.1 O51526 DPO3A_BORBU 50.526 0.969072 0.0845684 dnaE - DNA polymerase III subunit alpha - Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) - dnaE gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity). Indicus|evm.model.PRDE01196418.1.1 Q6AAU3 GLYA_CUTAK 48.739 0.906977 0.262729 glyA - Serine hydroxymethyltransferase - Cutibacterium acnes (strain DSM 16379 / KPA171202) - glyA gene Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Indicus|evm.model.PRDE01196586.1.1 A6L9D2 YIDC_PARD8 55.814 0.976744 0.135861 yidC - Membrane protein insertase YidC - Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152) - yidC gene Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. Indicus|evm.model.PRDE01196676.1.1 P45198 Y1424_HAEIN 45.283 0.990196 0.335526 HI_1424 - Putative integrase/recombinase HI_1414 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_1424 gene Indicus|evm.model.PRDE01196694.1.1 P40289 Y669_CUPNH 54.000 0.347826 0.505495 H16_A0669 - Putative tyrosine-protein phosphatase H16_A0669 precursor - Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) - H16_A0669 gene Indicus|evm.model.PRDE01196970.1.1 Q64Y97 RSMA_BACFR 78.295 0.992248 0.474265 rsmA - Ribosomal RNA small subunit methyltransferase A - Bacteroides fragilis (strain YCH46) - rsmA gene Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Indicus|evm.model.PRDE01197012.1.1 Q8R9T0 DEF_CALS4 66.316 0.878505 0.672956 def - Peptide deformylase - Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) - def gene Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. Indicus|evm.model.PRDE01197119.1.1 P35597 EXP7_STRPN 55.556 0.980645 0.199229 exp7 - Probable cation-transporting ATPase exp7 - Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) - exp7 gene Indicus|evm.model.PRDE01197350.1.1 Q7MT94 SYW_PORGI 82.524 0.971429 0.321101 trpS - Tryptophan--tRNA ligase - Porphyromonas gingivalis (strain ATCC BAA-308 / W83) - trpS gene Catalyzes the attachment of tryptophan to tRNA(Trp). Indicus|evm.model.PRDE01197370.1.1 Q46127 SYW_CLOLO 62.821 0.987261 0.460411 trpS - Tryptophan--tRNA ligase - Clostridium longisporum - trpS gene Catalyzes the attachment of tryptophan to tRNA(Trp). Indicus|evm.model.PRDE01197467.1.1 Q5LBG5 MURB_BACFN 74.000 0.907407 0.162651 murB - UDP-N-acetylenolpyruvoylglucosamine reductase - Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343) - murB gene Cell wall formation. Indicus|evm.model.PRDE01197520.1.1 Q0SR05 METK_CLOPS 64.516 0.7625 0.204604 metK - S-adenosylmethionine synthase - Clostridium perfringens (strain SM101 / Type A) - metK gene Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Indicus|evm.model.PRDE01197639.1.1 Q53044 GLNB_RHORT 48.544 0.971429 0.9375 glnB - Nitrogen regulatory protein P-II - Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) - glnB gene P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase, so activating the enzyme. Indicus|evm.model.PRDE01197858.1.1 Q8A1E7 PROB_BACTN 58.741 0.991803 0.338889 proB - Glutamate 5-kinase - Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) - proB gene Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. Indicus|evm.model.PRDE01197921.1.1 P54719 YFIC_BACSU 45.349 0.794393 0.177152 yfiC - Uncharacterized ABC transporter ATP-binding protein YfiC - Bacillus subtilis (strain 168) - yfiC gene ATPase-coupled transmembrane transporter activity, transmembrane transport Indicus|evm.model.PRDE01198543.1.1 P37624 RBBA_ECOLI 68.987 0.993671 0.173436 rbbA - Ribosome-associated ATPase - Escherichia coli (strain K12) - rbbA gene Exhibits an intrinsic ATPase activity that is stimulated by both 70S ribosomes and 30S ribosomal subunits. Could be involved in protein-chain elongation and in release of deacyl-tRNA from ribosomes after peptide bond synthesis. Stimulates the synthesis of polyphenylalanine in vitro. Indicus|evm.model.PRDE01204982.1.1 Q6D9J5 CUTA_PECAS 53.846 0.49505 0.918182 cutA - Divalent-cation tolerance protein CutA - Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) - cutA gene Involved in resistance toward heavy metals. Indicus|evm.model.PRDE01205145.1.1 P44718 Y454_HAEIN 48.039 0.863248 0.45 HI_0454 - Uncharacterized metal-dependent hydrolase HI_0454 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_0454 gene cytosol Indicus|evm.model.PRDE01205204.1.1 B4UT09 PI4KB_OTOGA 90.909 0.613208 0.129902 PI4KB - Phosphatidylinositol 4-kinase beta - Otolemur garnettii (Small-eared galago) - PI4KB gene Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). Indicus|evm.model.PRDE01205506.1.1 A4T9N5 TRPC_MYCGI 57.292 0.840708 0.415441 trpC - Indole-3-glycerol phosphate synthase - Mycolicibacterium gilvum (strain PYR-GCK) - trpC gene Indicus|evm.model.PRDE01205783.1.1 A1SNJ7 KAD_NOCSJ 60.902 0.970588 0.712042 adk - Adenylate kinase - Nocardioides sp. (strain ATCC BAA-499 / JS614) - adk gene Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Indicus|evm.model.PRDE01206444.1.1 A0R610 DPRE2_MYCS2 71.111 0.978022 0.358268 dprE2 - Decaprenylphosphoryl-2-keto-beta-D-erythro-pentose reductase - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - dprE2 gene Component of the DprE1-DprE2 complex that catalyzes the 2-step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX) (PubMed:22188377). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate channel' at the interface of DprE1-DprE2 complex (By similarity). DprE2 then catalyzes the second step of epimerization, the NAD(+)-dependent reduction of DPX that leads to the formation of DPA (PubMed:22188377). Indicus|evm.model.PRDE01206614.1.1 Q3JHZ1 RBSA2_BURP1 62.338 0.806452 0.179884 rbsA2 - Ribose import ATP-binding protein RbsA 2 - Burkholderia pseudomallei (strain 1710b) - rbsA2 gene Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01207177.1.1 P28306 MLTG_ECOLI 41.791 0.970803 0.402941 mltG - Endolytic murein transglycosylase - Escherichia coli (strain K12) - mltG gene Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Indicus|evm.model.PRDE01209524.1.1 Q8X968 AROP_ECO57 57.983 0.983333 0.262582 aroP - Aromatic amino acid transport protein AroP - Escherichia coli O157:H7 - aroP gene Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan). Indicus|evm.model.PRDE01209530.1.1 P13364 GYRB_PSEPU 77.966 0.95082 0.0756824 gyrB - DNA gyrase subunit B - Pseudomonas putida - gyrB gene A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. Indicus|evm.model.PRDE01210170.1.1 B8DDX7 PEPT_LISMH 46.923 0.992308 0.317073 pepT - Peptidase T - Listeria monocytogenes serotype 4a (strain HCC23) - pepT gene Cleaves the N-terminal amino acid of tripeptides. Indicus|evm.model.PRDE01210876.1.1 Q0J0H4 ODPB2_ORYSJ 63.971 0.971223 0.369681 Os09g0509200 - Pyruvate dehydrogenase E1 component subunit beta-2, mitochondrial precursor - Oryza sativa subsp. japonica (Rice) - Os09g0509200 gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Indicus|evm.model.PRDE01211148.1.1 B0SUP2 RL10_CAUSK 81.890 0.984375 0.744186 rplJ - 50S ribosomal protein L10 - Caulobacter sp. (strain K31) - rplJ gene Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Indicus|evm.model.PRDE01212087.1.1 E6X4P3 QUEG_CELAD 77.358 0.990566 0.346405 queG - Epoxyqueuosine reductase - Cellulophaga algicola (strain DSM 14237 / IC166 / ACAM 630) - queG gene Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). Indicus|evm.model.PRDE01213364.1.1 P35883 TRA0_MYCSM 48.673 0.732026 0.473684 Transposase for insertion sequence element IS6120 - Mycolicibacterium smegmatis Indicus|evm.model.PRDE01213680.1.1 Q9SWG0 IVD_ARATH 66.667 0.774775 0.271394 IVD - Isovaleryl-CoA dehydrogenase, mitochondrial precursor - Arabidopsis thaliana (Mouse-ear cress) - IVD gene Involved in degradation of the branched-chain amino acids, phytol and lysine for the supply of carbon and electrons to the ETF/ETFQO complex during dark-induced sugar starvation. Indicus|evm.model.PRDE01216265.1.3 P10484 T1M1_ECOLX 82.625 0.994231 1 hsdM - Type I restriction enzyme EcoR124II M protein - Escherichia coli - hsdM gene Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The EcoR124/3 I enzyme recognizes 5'-GAAN(7)RTCG-3'. Indicus|evm.model.PRDE01216267.1.5 P0C1G0 DGK2_LACAC 56.436 0.938967 0.934211 LBA1950 - Deoxyguanosine kinase - Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) - LBA1950 gene DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors, dGTP and dATP, for DNA metabolism. Indicus|evm.model.PRDE01216267.1.8 Q38YZ5 MURE_LACSS 60.000 0.995699 0.906433 murE - UDP-N-acetylmuramyl-tripeptide synthetase - Lactobacillus sakei subsp. sakei (strain 23K) - murE gene Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Indicus|evm.model.PRDE01216267.1.9 H8L902 ASL_ENTFU 56.892 0.994975 0.945368 EFAU004_01690 - D-aspartate ligase - Enterococcus faecium (strain Aus0004) - EFAU004_01690 gene Catalyzes the addition of D-aspartate onto the lysine residue in the peptidoglycan precursor UDP-MurNAc-pentapeptide. The ligation occurs between the beta-carboxylate of D-Asp and the epsilon-amino group of L-Lys. Is highly specific for D-aspartate, as L-aspartate, D-glutamate, D-alanine, D-iso-asparagine and D-malate are not substrates. Indicus|evm.model.PRDE01216267.1.10 H8L901 RACD_ENTFU 50.000 0.986726 0.930041 EFAU004_01689 - Aspartate racemase - Enterococcus faecium (strain Aus0004) - EFAU004_01689 gene Aspartate racemase that provides the D-aspartate required by the D-aspartate ligase to be added onto the lysine residue in the peptidoglycan precursor UDP-MurNAc-pentapeptide. Indicus|evm.model.PRDE01216267.1.13 Q03HR3 NANE_PEDPA 82.609 0.958115 0.834061 nanE - Putative N-acetylmannosamine-6-phosphate 2-epimerase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - nanE gene Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Indicus|evm.model.PRDE01216271.1.1 Q7A742 ADH_STAAN 71.014 0.490476 1.25 adh - Alcohol dehydrogenase - Staphylococcus aureus (strain N315) - adh gene Indicus|evm.model.PRDE01216271.1.2 Q5HRD6 ADH_STAEQ 70.000 0.945205 0.214706 adh - Alcohol dehydrogenase - Staphylococcus epidermidis (strain ATCC 35984 / RP62A) - adh gene Indicus|evm.model.PRDE01216271.1.5 O32090 PNCB_BACSU 59.823 0.818841 1.12653 pncB - Nicotinate phosphoribosyltransferase - Bacillus subtilis (strain 168) - pncB gene Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. Indicus|evm.model.PRDE01216271.1.6 Q88Z14 NADE_LACPL 76.555 0.985782 0.767273 nadE - NH(3)-dependent NAD(+) synthetase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - nadE gene Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. Indicus|evm.model.PRDE01216271.1.7 Q73E41 BACA1_BACC1 48.750 0.961798 1.00225 BCE_0519 - Calcium-transporting ATPase 1 - Bacillus cereus (strain ATCC 10987 / NRS 248) - BCE_0519 gene Catalyzes the hydrolysis of ATP coupled with the transport of calcium. Indicus|evm.model.PRDE01216271.1.8 O31489 YDCI_BACSU 54.663 0.989986 0.972184 ydcI - Uncharacterized protein YdcI - Bacillus subtilis (strain 168) - ydcI gene mRNA binding, structural constituent of ribosome, translation Indicus|evm.model.PRDE01216271.1.9 Q5XAF5 PTNAB_STRP6 52.609 0.948052 0.7 manX - PTS system mannose-specific EIIAB component - Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) - manX gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Indicus|evm.model.PRDE01216271.1.10 Q5XAF5 PTNAB_STRP6 46.104 0.136 3.40909 manX - PTS system mannose-specific EIIAB component - Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) - manX gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Indicus|evm.model.PRDE01216271.1.11 Q88YZ4 FABH1_LACPL 64.000 0.981424 1 fabH1 - 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - fabH1 gene Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids. Indicus|evm.model.PRDE01216271.1.12 Q58626 PYCA_METJA 45.161 0.926667 0.898204 pycA - Pyruvate carboxylase subunit A - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) - pycA gene Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Indicus|evm.model.PRDE01216271.1.13 A8M4V8 ACCDA_SALAI 59.804 0.893805 0.199647 accD - Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha - Salinispora arenicola (strain CNS-205) - accD gene Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity). Indicus|evm.model.PRDE01216271.1.14 Q0AVW1 ACCA_SYNWW 40.789 0.959641 0.701258 accA - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha - Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) - accA gene Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. Indicus|evm.model.PRDE01216271.1.15 Q88YY8 GPMA1_LACPL 70.721 0.977679 0.995556 gpmA1 - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - gpmA1 gene Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Indicus|evm.model.PRDE01216271.1.16 Q03E35 RPIA_PEDPA 87.379 0.320814 2.80263 rpiA - Ribose-5-phosphate isomerase A - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rpiA gene Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. Indicus|evm.model.PRDE01216271.1.17 Q8DRP0 RADA_STRR6 67.640 0.684474 1.42619 radA - DNA repair protein RadA - Streptococcus pneumoniae (strain ATCC BAA-255 / R6) - radA gene Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks (By similarity). Required for efficient transformation with chromosomal (linear) DNA, but not for replicative plasmid DNA. Its increased sensitivity to a DNA damaging agent suggests it may be required for DNA repair (PubMed:17631629). Indicus|evm.model.PRDE01216271.1.18 Q92F41 Y266_LISIN 51.642 0.922652 1.01401 lin0266 - Uncharacterized PIN and TRAM-domain containing protein Lin0266 - Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) - lin0266 gene An RNase. Indicus|evm.model.PRDE01216271.1.19 Q03E40 SYE_PEDPA 90.867 0.995327 0.864646 gltX - Glutamate--tRNA ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - gltX gene Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). Indicus|evm.model.PRDE01216271.1.20 Q03E41 SYC_PEDPA 80.995 0.786096 1.19362 cysS - Cysteine--tRNA ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - cysS gene Indicus|evm.model.PRDE01216271.1.21 Q5HRM1 TRMHL_STAEQ 54.891 0.478947 1.5261 SERP0172 - Putative TrmH family tRNA/rRNA methyltransferase - Staphylococcus epidermidis (strain ATCC 35984 / RP62A) - SERP0172 gene Indicus|evm.model.PRDE01216271.1.22 Q06795 NUSG_BACSU 65.306 0.979866 0.841808 nusG - Transcription termination/antitermination protein NusG - Bacillus subtilis (strain 168) - nusG gene Participates in transcription elongation, termination and antitermination. Stimulates RNA polymerase pausing at U107 and U144 in the trp leader. NusG-stimulated pausing is sequence specific. Does not affect trp leader termination. Indicus|evm.model.PRDE01216271.1.23 Q03E49 RL1_PEDPA 94.760 0.991304 1.00437 rplA - 50S ribosomal protein L1 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rplA gene Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. Indicus|evm.model.PRDE01216271.1.24 Q03E50 RL10_PEDPA 91.275 0.986667 0.892857 rplJ - 50S ribosomal protein L10 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rplJ gene Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Indicus|evm.model.PRDE01216271.1.25 Q03E51 RL7_PEDPA 94.215 0.983607 1.00826 rplL - 50S ribosomal protein L7/L12 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rplL gene Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation. Indicus|evm.model.PRDE01216271.1.26 Q9CBQ2 RIR2_MYCLE 52.263 0.979675 0.756923 nrdF - Ribonucleoside-diphosphate reductase subunit beta - Mycobacterium leprae (strain TN) - nrdF gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Indicus|evm.model.PRDE01216271.1.27 P0CH00 RIR1B_MYCS2 52.941 0.98338 1 nrdE2 - Ribonucleoside-diphosphate reductase subunit alpha 2 - Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) - nrdE2 gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Indicus|evm.model.PRDE01216271.1.28 P68999 TADA_STRP1 55.725 0.507812 1.49708 tadA - tRNA-specific adenosine deaminase - Streptococcus pyogenes serotype M1 - tadA gene Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2). Indicus|evm.model.PRDE01216271.1.29 P09122 DPO3X_BACSU 46.195 0.994662 0.998224 dnaX - DNA polymerase III subunit gamma/tau - Bacillus subtilis (strain 168) - dnaX gene DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. Indicus|evm.model.PRDE01216271.1.30 Q03E58 Y1483_PEDPA 85.567 0.979592 0.942308 PEPE_1483 - Nucleoid-associated protein PEPE_1483 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - PEPE_1483 gene Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. Indicus|evm.model.PRDE01216271.1.31 Q03E59 RECR_PEDPA 95.980 0.99 1.00503 recR - Recombination protein RecR - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - recR gene May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. Indicus|evm.model.PRDE01216271.1.32 Q03E60 KTHY_PEDPA 81.818 0.989362 0.899522 tmk - Thymidylate kinase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - tmk gene Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. Indicus|evm.model.PRDE01216271.1.33 P37544 RSMI_BACSU 51.838 0.410959 2.25 rsmI - Ribosomal RNA small subunit methyltransferase I - Bacillus subtilis (strain 168) - rsmI gene Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. Indicus|evm.model.PRDE01216271.1.34 Q03E69 TSAD_PEDPA 87.826 0.289806 3.44058 tsaD - tRNA N6-adenosine threonylcarbamoyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - tsaD gene Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. Indicus|evm.model.PRDE01216271.1.36 Q03E71 REX_PEDPA 62.209 0.95 0.865385 rex - Redox-sensing transcriptional repressor Rex - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rex gene Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. Indicus|evm.model.PRDE01216271.1.43 Q9CFC3 PEPDB_LACLA 70.474 0.890838 1.08228 pepDB - Probable dipeptidase B - Lactococcus lactis subsp. lactis (strain IL1403) - pepDB gene Indicus|evm.model.PRDE01216271.1.47 Q03E93 RNY2_PEDPA 72.692 0.996161 1.00192 rny2 - Ribonuclease Y 2 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rny2 gene Endoribonuclease that initiates mRNA decay. Indicus|evm.model.PRDE01216272.1.1 P77917 RPOC_PEDAC 99.045 0.854678 1.0436 rpoC - DNA-directed RNA polymerase subunit beta' - Pediococcus acidilactici - rpoC gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01216272.1.3 Q03EB2 RS12_PEDPA 100.000 0.985507 1.0073 rpsL - 30S ribosomal protein S12 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rpsL gene With S4 and S5 plays an important role in translational accuracy. Indicus|evm.model.PRDE01216272.1.4 Q03EB3 RS7_PEDPA 97.436 0.987261 1.00641 rpsG - 30S ribosomal protein S7 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rpsG gene One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA. Indicus|evm.model.PRDE01216272.1.5 Q03EB4 EFG_PEDPA 92.826 0.997135 1.00143 fusA - Elongation factor G - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - fusA gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Indicus|evm.model.PRDE01216272.1.6 Q03EB5 RS10_PEDPA 100.000 0.980583 1.0098 rpsJ - 30S ribosomal protein S10 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rpsJ gene Involved in the binding of tRNA to the ribosomes. Indicus|evm.model.PRDE01216272.1.7 Q03EB6 RL3_PEDPA 94.382 0.469496 1.79524 rplC - 50S ribosomal protein L3 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rplC gene One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. Indicus|evm.model.PRDE01216272.1.8 Q03EB8 RL23_PEDPA 93.671 0.975 0.842105 rplW - 50S ribosomal protein L23 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rplW gene One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome. Indicus|evm.model.PRDE01216272.1.9 Q03EB9 RL2_PEDPA 93.274 0.521127 1.51064 rplB - 50S ribosomal protein L2 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rplB gene One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Indicus|evm.model.PRDE01216272.1.10 Q03EC3 RL16_PEDPA 96.875 0.984496 0.895833 rplP - 50S ribosomal protein L16 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rplP gene Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs. Indicus|evm.model.PRDE01216272.1.11 Q03EC8 RL5_PEDPA 95.092 0.61597 1.46111 rplE - 50S ribosomal protein L5 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rplE gene This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. Indicus|evm.model.PRDE01216272.1.12 Q03ED0 RS8_PEDPA 97.368 0.982609 0.871212 rpsH - 30S ribosomal protein S8 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rpsH gene One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit. Indicus|evm.model.PRDE01216272.1.13 Q03ED3 RS5_PEDPA 95.000 0.36891 2.58084 rpsE - 30S ribosomal protein S5 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rpsE gene With S4 and S12 plays an important role in translational accuracy. Indicus|evm.model.PRDE01216272.1.14 F6CD01 SECY1_LACKZ 63.469 0.989011 0.633411 secY - Protein translocase subunit SecY 1 - Lactobacillus kefiranofaciens (strain ZW3) - secY gene The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. Indicus|evm.model.PRDE01216272.1.15 B2G8V7 KAD_LACRJ 77.528 0.988827 0.824885 adk - Adenylate kinase - Lactobacillus reuteri (strain JCM 1112) - adk gene Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Indicus|evm.model.PRDE01216272.1.16 Q03EE1 RS11_PEDPA 100.000 0.41704 1.72868 rpsK - 30S ribosomal protein S11 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rpsK gene Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. Indicus|evm.model.PRDE01216272.1.17 Q03EE2 RPOA_PEDPA 95.223 0.993651 1.00318 rpoA - DNA-directed RNA polymerase subunit alpha - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rpoA gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Indicus|evm.model.PRDE01216272.1.18 Q03EE4 ECFA_PEDPA 73.162 0.450166 2.15 ecfA - Energy-coupling factor transporter ATP-binding protein EcfA - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - ecfA gene ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. Indicus|evm.model.PRDE01216272.1.19 Q88XU9 TRUA_LACPL 67.206 0.56422 1.66412 truA - tRNA pseudouridine synthase A - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - truA gene Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. Indicus|evm.model.PRDE01216272.1.21 Q08352 DHA_BACSU 52.459 0.429825 2.11111 ald - Alanine dehydrogenase - Bacillus subtilis (strain 168) - ald gene Catalyzes the reversible oxidative deamination of L-alanine to pyruvate. This enzyme is a key factor in the assimilation of L-alanine as an energy source through the tricarboxylic acid cycle during sporulation. Indicus|evm.model.PRDE01216272.1.25 O32083 LYTG_BACSU 46.405 0.863636 0.624113 lytG - Exo-glucosaminidase LytG precursor - Bacillus subtilis (strain 168) - lytG gene Is the major glucosaminidase responsible for peptidoglycan structural determination during vegetative growth. Catalyzes the hydrolysis of 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid residues in peptidoglycan. Acts processively from the ends of the glycan strands. Also plays a role in motility, chemotaxis and cell division. Indicus|evm.model.PRDE01216272.1.26 Q03EG0 XPT_PEDPA 92.742 0.984 0.657895 xpt - Xanthine phosphoribosyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - xpt gene Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. Indicus|evm.model.PRDE01216272.1.28 Q9S3Q0 PCRA_LEUCI 58.311 0.994528 0.975968 pcrA - ATP-dependent DNA helicase PcrA - Leuconostoc citreum - pcrA gene Essential helicase. Indicus|evm.model.PRDE01216272.1.30 Q03EG5 GATA_PEDPA 89.095 0.995893 1.00206 gatA - Glutamyl-tRNA(Gln) amidotransferase subunit A - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - gatA gene Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Indicus|evm.model.PRDE01216272.1.31 Q03EG6 GATB_PEDPA 90.843 0.995192 0.875789 gatB - Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - gatB gene Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Indicus|evm.model.PRDE01216272.1.32 O31502 DAGK_BACSU 57.241 0.870482 1.09571 dagK - Diacylglycerol kinase - Bacillus subtilis (strain 168) - dagK gene Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway. Is more active toward long-chain DAG compared with short-chain DAG. Is not able to phosphorylate substrates other than DAG, such as monoacylglycerol, ceramide, undecaprenol, phosphatidylinositol, or sphingosine. Indicus|evm.model.PRDE01216272.1.33 Q88XP4 Y1151_LACPL 60.829 0.993056 0.945295 lp_1151 - Uncharacterized RNA methyltransferase lp_1151 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - lp_1151 gene Indicus|evm.model.PRDE01216272.1.37 Q88XG4 Y1241_LACPL 70.000 0.973856 0.840659 lp_1241 - UPF0374 protein lp_1241 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - lp_1241 gene Indicus|evm.model.PRDE01216272.1.39 Q03GI2 RF3_PEDPA 92.720 0.996176 1.00192 prfC - Peptide chain release factor 3 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - prfC gene Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Indicus|evm.model.PRDE01216272.1.40 O34952 LTAS2_BACSU 48.090 0.840708 1.04468 ltaS2 - Lipoteichoic acid synthase 2 - Bacillus subtilis (strain 168) - ltaS2 gene Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate. Indicus|evm.model.PRDE01216272.1.42 Q03HZ9 SECA2_PEDPA 77.958 0.988506 0.551331 secA2 - Protein translocase subunit SecA 2 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - secA2 gene Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Indicus|evm.model.PRDE01216272.1.43 Q03HZ9 SECA2_PEDPA 67.528 0.974729 0.351077 secA2 - Protein translocase subunit SecA 2 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - secA2 gene Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Indicus|evm.model.PRDE01216272.1.49 P54448 YQEC_BACSU 55.556 0.986254 0.979798 yqeC - Putative 6-phosphogluconate dehydrogenase YqeC - Bacillus subtilis (strain 168) - yqeC gene May act as NAD-dependent 6-P-gluconate dehydrogenase. Indicus|evm.model.PRDE01216272.1.50 P12011 GNTK_BACSU 51.931 0.966667 0.935673 gntK - Gluconokinase - Bacillus subtilis (strain 168) - gntK gene Indicus|evm.model.PRDE01216272.1.51 O31862 YOJA_BACSU 59.756 0.995134 0.925676 yojA - Uncharacterized permease YojA - Bacillus subtilis (strain 168) - yojA gene integral component of plasma membrane, gluconate transmembrane transporter activity, gluconate transmembrane transport Indicus|evm.model.PRDE01216272.1.52 Q4A0G5 ISAA_STAS1 68.421 0.172414 1.79012 isaA - Probable transglycosylase IsaA precursor - Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) - isaA gene Is able to cleave peptidoglycan. Indicus|evm.model.PRDE01216272.1.53 P94413 YCLJ_BACSU 53.219 0.377236 2.70925 yclJ - Uncharacterized transcriptional regulatory protein YclJ - Bacillus subtilis (strain 168) - yclJ gene Could be member of the two-component regulatory system YclK/YclJ. Indicus|evm.model.PRDE01216272.1.55 P0A4S2 ALF_STRR6 61.667 0.97479 0.812287 fba - Fructose-bisphosphate aldolase - Streptococcus pneumoniae (strain ATCC BAA-255 / R6) - fba gene Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. Indicus|evm.model.PRDE01216272.1.56 Q88UI3 Y2503_LACPL 56.872 0.990566 0.74386 lp_2503 - Putative sugar uptake protein lp_2503 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - lp_2503 gene Indicus|evm.model.PRDE01216272.1.57 Q03EI3 G6PI_PEDPA 94.655 0.993348 1.00445 pgi - Glucose-6-phosphate isomerase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - pgi gene Indicus|evm.model.PRDE01216272.1.58 F8DIF2 URDA_STREP 55.488 0.976048 0.20797 urdA - Urocanate reductase - Streptococcus parasanguinis (strain ATCC 15912 / DSM 6778 / CIP 104372 / LMG 14537) - urdA gene Catalyzes the two-electron reduction of urocanate to dihydrourocanate (also named imidazole propionate or deamino-histidine). Dihydrourocanate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria S.parasanguinis strain ATCC 15912 may contribute to the pathogenesis of type 2 diabetes by producing the microbial metabolite dihydrourocanate. Indicus|evm.model.PRDE01216272.1.60 Q88ZS9 GREA1_LACPL 56.849 0.97973 0.948718 greA1 - Transcription elongation factor GreA 1 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - greA1 gene Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. Indicus|evm.model.PRDE01216272.1.63 P9WQJ3 FATRP_MYCTU 51.724 0.966597 0.759113 Rv1272c - Fatty acid ABC transporter ATP-binding/permease protein - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1272c gene ABC transporter involved in fatty acid import (PubMed:29360453). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable). Indicus|evm.model.PRDE01216272.1.65 Q59935 MANA_STRMU 54.545 0.981203 0.841772 pmi - Mannose-6-phosphate isomerase - Streptococcus mutans serotype c (strain ATCC 700610 / UA159) - pmi gene Indicus|evm.model.PRDE01216272.1.66 Q8DNZ8 GATD_STRR6 55.610 0.315217 2.47692 gatD - Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD - Streptococcus pneumoniae (strain ATCC BAA-255 / R6) - gatD gene The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide (PubMed:24044435, PubMed:30093673). The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT (PubMed:30093673). Indicus|evm.model.PRDE01216272.1.67 Q03QX7 RF1_LACBA 79.261 0.699203 1.39058 prfA - Peptide chain release factor 1 - Lactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947) - prfA gene Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. Indicus|evm.model.PRDE01216272.1.68 Q03EK4 GLYA_PEDPA 82.885 0.428571 2.32195 glyA - Serine hydroxymethyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - glyA gene Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Indicus|evm.model.PRDE01216272.1.69 Q03EK5 UPP_PEDPA 98.086 0.990476 1.00478 upp - Uracil phosphoribosyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - upp gene Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. Indicus|evm.model.PRDE01216272.1.72 Q03EL0 ATPF_PEDPA 92.000 0.491749 1.75145 atpF - ATP synthase subunit b - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - atpF gene F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Indicus|evm.model.PRDE01216272.1.73 Q03EL2 ATPA_PEDPA 94.595 0.995506 0.881188 atpA - ATP synthase subunit alpha - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - atpA gene Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Indicus|evm.model.PRDE01216272.1.74 Q03EL3 ATPG_PEDPA 87.948 0.993506 1.00654 atpG - ATP synthase gamma chain - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - atpG gene Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. Indicus|evm.model.PRDE01216272.1.75 Q03EL4 ATPB_PEDPA 96.162 0.995745 1.00213 atpD - ATP synthase subunit beta - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - atpD gene Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. Indicus|evm.model.PRDE01216272.1.76 Q03EL5 ATPE_PEDPA 91.228 0.982609 0.827338 atpC - ATP synthase epsilon chain - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - atpC gene Produces ATP from ADP in the presence of a proton gradient across the membrane. Indicus|evm.model.PRDE01216272.1.78 Q88UV2 METN2_LACPL 66.860 0.939726 1.06414 metN2 - Methionine import ATP-binding protein MetN 2 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - metN2 gene Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01216272.1.84 Q03EM9 DDL_PEDPA 84.127 0.993671 0.900285 ddl - D-alanine--D-alanine ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - ddl gene Cell wall formation. Indicus|evm.model.PRDE01216272.1.85 O34528 YRVN_BACSU 62.632 0.804671 1.11876 yrvN - Uncharacterized AAA domain-containing protein YrvN - Bacillus subtilis (strain 168) - yrvN gene enzyme activator activity, single-stranded DNA helicase activity, DNA-dependent DNA replication, regulation of DNA repair Indicus|evm.model.PRDE01216272.1.86 Q03EN4 RS4_PEDPA 93.514 0.541176 1.68317 rpsD - 30S ribosomal protein S4 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rpsD gene One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. Indicus|evm.model.PRDE01216272.1.88 P31672 NIFS_LACDA 58.960 0.988539 0.906494 Ldb0724 - NifS/IcsS protein homolog - Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14) - Ldb0724 gene Indicus|evm.model.PRDE01216272.1.89 Q03EN8 THII_PEDPA 88.471 0.995 0.987654 thiI - Probable tRNA sulfurtransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - thiI gene Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. Indicus|evm.model.PRDE01216272.1.90 Q88UX7 SYV_LACPL 77.656 0.995134 0.924634 valS - Valine--tRNA ligase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - valS gene Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner. Indicus|evm.model.PRDE01216272.1.93 P54537 ARTM_BACSU 51.938 0.820513 0.65 artM - Arginine transport ATP-binding protein ArtM - Bacillus subtilis (strain 168) - artM gene Part of a binding-protein-dependent transport system for arginine. Probably responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01216272.1.95 P71040 CLSA_BACSU 49.337 0.994709 0.784232 clsA - Major cardiolipin synthase ClsA - Bacillus subtilis (strain 168) - clsA gene Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Indicus|evm.model.PRDE01216272.1.99 Q03EQ4 CINA_PEDPA 69.007 0.995169 1.00242 cinA - Putative competence-damage inducible protein - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - cinA gene Indicus|evm.model.PRDE01216272.1.100 Q88UZ4 RECA_LACPL 83.438 0.981538 0.855263 recA - Protein RecA - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - recA gene Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. Indicus|evm.model.PRDE01216272.1.101 Q03EQ6 RNY1_PEDPA 90.543 0.995984 0.959538 rny1 - Ribonuclease Y 1 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rny1 gene Endoribonuclease that initiates mRNA decay. Indicus|evm.model.PRDE01216272.1.102 Q03EQ7 MUTS_PEDPA 82.919 0.99774 1.01375 mutS - DNA mismatch repair protein MutS - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - mutS gene This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. Indicus|evm.model.PRDE01216272.1.103 Q03EQ8 MUTL_PEDPA 73.790 0.99661 0.914729 mutL - DNA mismatch repair protein MutL - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - mutL gene This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. Indicus|evm.model.PRDE01216272.1.104 Q03EQ9 RUVA_PEDPA 75.897 0.989796 1.00513 ruvA - Holliday junction ATP-dependent DNA helicase RuvA - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - ruvA gene The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. Indicus|evm.model.PRDE01216272.1.105 Q03ER0 RUVB_PEDPA 90.566 0.992481 0.789318 ruvB - Holliday junction ATP-dependent DNA helicase RuvB - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - ruvB gene The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. Indicus|evm.model.PRDE01216272.1.106 Q03ER1 QUEA_PEDPA 88.889 0.993671 0.918605 queA - S-adenosylmethionine:tRNA ribosyltransferase-isomerase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - queA gene Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). Indicus|evm.model.PRDE01216272.1.107 Q03ER2 TGT_PEDPA 93.413 0.99403 0.881579 tgt - Queuine tRNA-ribosyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - tgt gene Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Indicus|evm.model.PRDE01216272.1.108 O32052 YRBF_BACSU 51.852 0.64 1.40449 yrbF - Sec translocon accessory complex subunit YrbF - Bacillus subtilis (strain 168) - yrbF gene The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. Indicus|evm.model.PRDE01216272.1.109 P54547 G6PD_BACSU 49.189 0.978667 0.766871 zwf - Glucose-6-phosphate 1-dehydrogenase - Bacillus subtilis (strain 168) - zwf gene Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Indicus|evm.model.PRDE01216272.1.110 Q88V07 DPO4_LACPL 60.870 0.991304 0.915119 dinB - DNA polymerase IV - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - dinB gene Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. Indicus|evm.model.PRDE01216272.1.111 Q8DTN6 NRNA_STRMU 50.607 0.991935 0.8 nrnA - Probable bifunctional oligoribonuclease and PAP phosphatase NrnA - Streptococcus mutans serotype c (strain ATCC 700610 / UA159) - nrnA gene Probable bifunctional enzyme which has pAp-phosphatase and may have oligoribonuclease activities. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. Complementation studies suggest it also has RNA oligoribonuclease activity, although this has not been shown in vitro using 5- or 20-mers. Involved in superoxide stress response and sulfur assimilation. Indicus|evm.model.PRDE01216272.1.112 Q8Y755 CSHB_LISMO 52.381 0.922907 1.04368 cshB - DEAD-box ATP-dependent RNA helicase CshB - Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) - cshB gene DEAD-box RNA helicase involved in cold tolerance, motility, and tolerance to heat, alkali and oxidative stress. Indicus|evm.model.PRDE01216272.1.113 Q03ER8 SYA_PEDPA 86.007 0.995465 1.00114 alaS - Alanine--tRNA ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - alaS gene Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. Indicus|evm.model.PRDE01216272.1.114 Q03ES2 MUTS2_PEDPA 81.946 0.800821 1.24076 mutS2 - Endonuclease MutS2 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - mutS2 gene Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity. Indicus|evm.model.PRDE01216272.1.115 P46893 PPSA_STAMF 49.936 0.97644 0.916067 ppsA - Probable phosphoenolpyruvate synthase - Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) - ppsA gene Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. Indicus|evm.model.PRDE01216272.1.116 Q88V20 IXTPA_LACPL 56.477 0.969697 0.980198 lp_2267 - dITP/XTP pyrophosphatase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - lp_2267 gene Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Indicus|evm.model.PRDE01216272.1.119 O84913 PEPQ_LACHE 59.229 0.989041 0.991848 pepQ - Xaa-Pro dipeptidase - Lactobacillus helveticus - pepQ gene Indicus|evm.model.PRDE01216272.1.120 O07329 CCPA_STRMU 56.190 0.993671 0.948949 ccpA - Catabolite control protein A - Streptococcus mutans serotype c (strain ATCC 700610 / UA159) - ccpA gene Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Indicus|evm.model.PRDE01216272.1.122 Q03ET4 PURA_PEDPA 89.277 0.988453 1.00464 purA - Adenylosuccinate synthetase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - purA gene Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Indicus|evm.model.PRDE01216272.1.123 P72478 PUR8_STRMU 59.716 0.990588 0.983796 purB - Adenylosuccinate lyase - Streptococcus mutans serotype c (strain ATCC 700610 / UA159) - purB gene Indicus|evm.model.PRDE01216272.1.124 Q838Z5 EFP_ENTFA 72.340 0.21934 2.27957 efp - Elongation factor P - Enterococcus faecalis (strain ATCC 700802 / V583) - efp gene Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. Indicus|evm.model.PRDE01216272.1.125 Q03EU1 Y1240_PEDPA 93.061 0.99187 1.00408 PEPE_1240 - Probable transcriptional regulatory protein PEPE_1240 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - PEPE_1240 gene Indicus|evm.model.PRDE01216272.1.126 P83534 RBSKI_LACSD 52.000 0.980263 0.562963 rbsK/rbiA - Bifunctional ribokinase/ribose-5-phosphate isomerase A - Lactobacillus sanfranciscensis (strain ATCC 27651 / DSM 20451 / JCM 5668 / KCTC 3205 / NCIMB 702811 / NRRL B-3934 / L-12) - rbsK/rbiA gene Bifunctional enzyme that catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium, and the reversible conversion of ribose 5-phosphate to ribulose 5-phosphate. Indicus|evm.model.PRDE01216272.1.129 O32127 YUTD_BACSU 47.191 0.133028 7.18681 yutD - Putative antitoxin YutD - Bacillus subtilis (strain 168) - yutD gene Probable antitoxin component of a putative type VII toxin-antitoxin (TA) system. Probably neutralizes cognate toxin YutE. Indicus|evm.model.PRDE01216272.1.130 Q7A1D4 NAGD_STAAW 49.793 0.983539 0.938224 nagD - Acid sugar phosphatase - Staphylococcus aureus (strain MW2) - nagD gene Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro. Indicus|evm.model.PRDE01216289.1.1 Q8ZNN5 APBC_SALTY 64.706 0.944 0.338753 apbC - Iron-sulfur cluster carrier protein - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - apbC gene Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins (PubMed:18616280, PubMed:19001370). Can hydrolyze ATP (PubMed:12486045, PubMed:19001370). Both activities are required for function in vivo, but the ability to hydrolyze ATP is not necessary for Fe-S cluster transfer (PubMed:19001370). Indicus|evm.model.PRDE01216304.1.3 P04130 TNR2_ECOLX 51.445 0.933702 0.973118 tnpR - Transposon Tn21 resolvase - Escherichia coli - tnpR gene Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products. Indicus|evm.model.PRDE01216305.1.1 P39347 INTB_ECOLI 57.506 0.899083 1.10101 intB - Putative protein IntB - Escherichia coli (strain K12) - intB gene Indicus|evm.model.PRDE01216305.1.8 O34469 YEEB_BACSU 48.450 0.595517 1.71285 yeeB - Putative ATP-dependent helicase YeeB - Bacillus subtilis (strain 168) - yeeB gene Indicus|evm.model.PRDE01216306.1.1 Q884N3 SPEE_PSESM 81.119 0.993031 1.0035 speE - Polyamine aminopropyltransferase - Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) - speE gene Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. Indicus|evm.model.PRDE01216309.1.1 Q8DPV9 AGGDS_STRR6 51.497 0.976401 0.906417 cpoA - Alpha-galactosylglucosyldiacylglycerol synthase - Streptococcus pneumoniae (strain ATCC BAA-255 / R6) - cpoA gene Galactosyltransferase involved in the biosynthesis of the bilayer-forming membrane lipid alpha-galactosyl-glucosyldiacylglycerol which is involved in maintaining constant nonbilayer/bilayer conditions (curvature packing stress). Also involved in the beta-lactam resistance. Catalyzes the transfer of a galactosyl residue from UDP-Gal to alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol) acceptor to form the corresponding galactosyl-glycosyl-DAG product (3-O-alpha-(D-galactopyranosyl-alpha-(1->2)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol). It can only use UDP-Gal as sugar donor and alpha-glucosyl-DAG is the preferred sugar acceptor. Indicus|evm.model.PRDE01216309.1.2 Q8CWR6 AMGDS_STRR6 47.297 0.67098 1.22676 spr0982 - Alpha-monoglucosyldiacylglycerol synthase - Streptococcus pneumoniae (strain ATCC BAA-255 / R6) - spr0982 gene Glucosyltransferase involved in the biosynthesis of the non-bilayer-prone membrane lipid alpha-monoglucosyldiacylglycerol. This is a major component for maintaining a certain anionic lipid surface charge density, for balancing the bilayer to non-bilayer phase equilibria and for keeping a constant lipid bilayer spontaneous curvature (curvature packing stress). Catalyzes the transfer of a glucosyl residue from UDP-Glc to diacylglycerol (DAG) acceptor to form the corresponding alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol). It can only use UDP-Glc as sugar donor. Indicus|evm.model.PRDE01216309.1.3 O07126 PT1_LACSK 67.951 0.989565 1.00174 ptsI - Phosphoenolpyruvate-protein phosphotransferase - Lactobacillus sakei - ptsI gene General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). Indicus|evm.model.PRDE01216309.1.4 Q9S5Z2 CLPE_LACLM 64.497 0.978691 0.878342 clpE - ATP-dependent Clp protease ATP-binding subunit ClpE - Lactococcus lactis subsp. cremoris (strain MG1363) - clpE gene Along with ClpP could be necessary for degrading proteins generated by certain types of stress. Indicus|evm.model.PRDE01216309.1.5 Q03GJ0 GUAC_PEDPA 90.462 0.993865 1.00308 guaC - GMP reductase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - guaC gene Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Indicus|evm.model.PRDE01216309.1.11 P37279 ATCS_SYNE7 51.031 0.979167 0.771084 pacS - Probable copper-transporting ATPase PacS - Synechococcus elongatus (strain PCC 7942 / FACHB-805) - pacS gene May play a role in the osmotic adaptation. Indicus|evm.model.PRDE01216309.1.12 O07127 YPTY_LACSK 52.688 0.442308 1.42466 Uncharacterized 16.5 kDa protein in ptsI 3'region - Lactobacillus sakei Indicus|evm.model.PRDE01216309.1.16 P39795 TREC_BACSU 50.090 0.98725 0.97861 treA - Trehalose-6-phosphate hydrolase - Bacillus subtilis (strain 168) - treA gene Hydrolyzes trehalose-6-phosphate to glucose and glucose 6-phosphate. Can also very effectively hydrolyzes p-nitrophenyl-alpha-D-glucopyranoside, but not lactose, maltose, sucrose or sucrose-6-phosphate. Trehalose is also hydrolyzed, but to a much smaller extent than trehalose-6-phosphate. Indicus|evm.model.PRDE01216309.1.21 P37747 GLF_ECOLI 57.377 0.970745 1.02452 glf - UDP-galactopyranose mutase - Escherichia coli (strain K12) - glf gene Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF). Indicus|evm.model.PRDE01216309.1.22 Q04664 CPSE_STRA3 51.515 0.400491 0.906459 cpsE - Galactosyl transferase CpsE - Streptococcus agalactiae serotype III (strain NEM316) - cpsE gene Galactosyl transferase is essential for the assembly of the group B streptococci (GBS) type III capsular polysaccharide. May be involved in the formation of either or both galactosidic bonds by catalyzing the addition of galactose to an oligosaccharide precursor or to a lipid intermediate. Type III capsular polysaccharide consists of a linear backbone with short side chains ending in residues of N-acetylneuraminic acid or sialic acid. The presence of sialic acid on the surface of the organism inhibits activation of the alternative pathway of complement and is thought to be an important element in the virulence function of the capsule. Indicus|evm.model.PRDE01216309.1.23 P71051 YVEL_BACSU 45.070 0.875776 0.709251 yveL - Putative tyrosine-protein kinase YveL - Bacillus subtilis (strain 168) - yveL gene Indicus|evm.model.PRDE01216309.1.26 O34748 RECQ_BACSU 51.743 0.723861 1.26227 recQ - Probable ATP-dependent DNA helicase RecQ - Bacillus subtilis (strain 168) - recQ gene Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with RecS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks. Indicus|evm.model.PRDE01216309.1.28 Q03GM4 THIE_PEDPA 68.984 0.560241 1.53704 thiE - Thiamine-phosphate synthase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - thiE gene Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Indicus|evm.model.PRDE01216316.1.6 Q9WZY4 METY_THEMA 59.242 0.983568 0.990698 TM_0882 - O-acetyl-L-homoserine sulfhydrylase - Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) - TM_0882 gene Catalyzes the production of homocysteine from O-acetylhomoserine (OAH) and hydrogen sulfide (H2S), a step in the methionine biosynthesis pathway. Is not able to form cystathionine from O-acetylhomoserine and L-cysteine. Indicus|evm.model.PRDE01216326.1.1 Q9LJ45 CCU11_ARATH 52.128 0.184426 2.32381 CYCU1-1 - Cyclin-U1-1 - Arabidopsis thaliana (Mouse-ear cress) - CYCU1-1 gene Indicus|evm.model.PRDE01216329.1.1 C5CC49 RS8_MICLC 68.142 0.988372 0.651515 rpsH - 30S ribosomal protein S8 - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) - rpsH gene One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit. Indicus|evm.model.PRDE01216331.1.1 P25524 CODA_ECOLI 59.722 0.400223 2.1007 codA - Cytosine deaminase - Escherichia coli (strain K12) - codA gene Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5-fluorocytosine (5FC) to 5-fluorouracil (5FU); this activity allows the formation of a cytotoxic chemotherapeutic agent from a non-cytotoxic precursor. Indicus|evm.model.PRDE01216331.1.2 Q9KHT9 OPUCA_LISMN 50.505 0.280627 1.76826 opuCA - Carnitine transport ATP-binding protein OpuCA - Listeria monocytogenes - opuCA gene Part of the ABC transporter complex OpuCABCD involved in carnitine uptake. Probably responsible for energy coupling to the transport system. Involved, with BetL and GbuABC, in osmoprotection and cryoprotection of Listeria. Indicus|evm.model.PRDE01216331.1.3 P26235 NAPA_ENTHR 51.087 0.983871 0.48564 napA - Na(+)/H(+) antiporter - Enterococcus hirae - napA gene Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Can also transport lithium. Indicus|evm.model.PRDE01216331.1.5 Q9CJD1 SYW_LACLA 69.547 0.987603 0.709677 trpS - Tryptophan--tRNA ligase - Lactococcus lactis subsp. lactis (strain IL1403) - trpS gene Catalyzes the attachment of tryptophan to tRNA(Trp). Indicus|evm.model.PRDE01216331.1.10 Q88Z97 SYM_LACPL 71.408 0.994083 0.989751 metG - Methionine--tRNA ligase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - metG gene Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. Indicus|evm.model.PRDE01216331.1.12 Q03HF6 RSMA_PEDPA 80.678 0.84 1.17845 rsmA - Ribosomal RNA small subunit methyltransferase A - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rsmA gene Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Indicus|evm.model.PRDE01216331.1.13 Q03HF4 ISPE_PEDPA 88.693 0.992958 1.00353 ispE - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - ispE gene Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Indicus|evm.model.PRDE01216331.1.21 A2RIE6 PTCB_LACLM 50.617 0.902439 0.759259 ptcB - PTS system galactose-specific EIIB component - Lactococcus lactis subsp. cremoris (strain MG1363) - ptcB gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity). Involved in galactose transport with PtcA and Lmg_0963 (PubMed:30123211). Indicus|evm.model.PRDE01216331.1.22 P42973 BGLA_BACSU 54.968 0.629842 1.45511 bglA - Aryl-phospho-beta-D-glucosidase BglA - Bacillus subtilis (strain 168) - bglA gene Catalyzes the hydrolysis of aryl-phospho-beta-D-glucosides such as 4-methylumbelliferyl-phospho-beta-D-glucopyranoside (MUG-P), phosphoarbutin and phosphosalicin. Plays a major role in the utilization of arbutin or salicin as the sole carbon source. BglA and BglH are the major proteins contributing to hydrolysis of MUG-P by extracts of late-exponential-phase or stationary-phase B.subtilis cells. Indicus|evm.model.PRDE01216331.1.23 P37061 NAOX_ENTFA 53.109 0.976982 0.876682 nox - NADH oxidase - Enterococcus faecalis (strain ATCC 700802 / V583) - nox gene Catalyzes the four-electron reduction of molecular oxygen to water. Indicus|evm.model.PRDE01216331.1.24 Q48436 BUDC_KLEPN 66.400 0.988095 0.984375 budC - Diacetyl reductase [(S)-acetoin forming] - Klebsiella pneumoniae - budC gene Catalyzes the reversible reduction of (S)-acetoin to 2,3-butanediol in the presence of NADH. Indicus|evm.model.PRDE01216331.1.26 P44023 Y594_HAEIN 61.060 0.529988 1.60511 HI_0594 - Uncharacterized protein HI_0594 - Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) - HI_0594 gene plasma membrane Indicus|evm.model.PRDE01216331.1.27 P37551 PURR_BACSU 50.542 0.919463 1.04561 purR - Pur operon repressor - Bacillus subtilis (strain 168) - purR gene Controls the transcription of the pur operon for purine biosynthetic genes, binds to the control region of the operon. DNA binding is inhibited by 5-phosphoribosyl 1-pyrophosphate. Indicus|evm.model.PRDE01216331.1.28 Q03HD2 GLMU_PEDPA 87.385 0.993151 0.937901 glmU - Bifunctional protein GlmU - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - glmU gene Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. Indicus|evm.model.PRDE01216331.1.29 Q21HE4 FABV_SACD2 46.875 0.959799 1.00759 fabV - Enoyl-[acyl-carrier-protein] reductase [NADH] - Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) - fabV gene Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Indicus|evm.model.PRDE01216331.1.30 Q88Z84 KPRS1_LACPL 87.346 0.990798 1 prs1 - Ribose-phosphate pyrophosphokinase 1 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - prs1 gene Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). Indicus|evm.model.PRDE01216331.1.32 F9UUD2 GLPF6_LACPL 64.535 0.971591 0.814815 glpF6 - Glycerol uptake facilitator protein-like 6 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - glpF6 gene Probable transporter that facilitates the transmembrane diffusion of an unknown substrate. Is not permeable to water, dihydroxyacetone, glycerol, urea, H(2)O(2) and D/L-lactic acid. Indicus|evm.model.PRDE01216331.1.36 B2GE56 ASNA_LACF3 74.914 0.993127 0.866071 asnA - Aspartate--ammonia ligase - Lactobacillus fermentum (strain NBRC 3956 / LMG 18251) - asnA gene Indicus|evm.model.PRDE01216331.1.37 O34987 PBUG_BACSU 56.168 0.974359 0.886364 pbuG - Guanine/hypoxanthine permease PbuG - Bacillus subtilis (strain 168) - pbuG gene Involved in the uptake of the purine bases hypoxanthine and guanine. Indicus|evm.model.PRDE01216331.1.42 Q74J27 PYRE_LACJO 57.426 0.922018 1.0283 pyrE - Orotate phosphoribosyltransferase - Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533) - pyrE gene Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). Indicus|evm.model.PRDE01216331.1.43 Q03HB3 PYRB_PEDPA 77.358 0.992481 0.863636 pyrB - Aspartate carbamoyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - pyrB gene Indicus|evm.model.PRDE01216331.1.44 Q03HB2 PYRC_PEDPA 74.528 0.627723 1.18824 pyrC - Dihydroorotase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - pyrC gene Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. Indicus|evm.model.PRDE01216331.1.45 P77885 CARA_LACPL 76.860 0.909091 0.362637 pyrAA - Carbamoyl-phosphate synthase pyrimidine-specific small chain - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - pyrAA gene Indicus|evm.model.PRDE01216331.1.46 Q03HB0 CARB_PEDPA 89.446 0.994737 0.359508 carB - Carbamoyl-phosphate synthase large chain - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - carB gene Indicus|evm.model.PRDE01216331.1.47 Q03HB0 CARB_PEDPA 73.037 0.997041 0.639546 carB - Carbamoyl-phosphate synthase large chain - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - carB gene Indicus|evm.model.PRDE01216331.1.48 Q03HA9 PYRDA_PEDPA 73.145 0.979094 0.944079 pyrD - Putative dihydroorotate dehydrogenase A (fumarate) - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - pyrD gene Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Indicus|evm.model.PRDE01216331.1.52 Q03H91 NAGB_PEDPA 91.453 0.250807 3.93644 nagB - Glucosamine-6-phosphate deaminase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - nagB gene Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. Indicus|evm.model.PRDE01216331.1.57 Q8NZA2 NRDIL_STRP8 49.020 0.955696 1.03947 spyM18_2048 - Putative NrdI-like protein - Streptococcus pyogenes serotype M18 (strain MGAS8232) - spyM18_2048 gene Indicus|evm.model.PRDE01216331.1.59 O86311 MEATP_MYCTU 53.982 0.836431 0.864952 Rv1218c - Multidrug efflux system ATP-binding protein Rv1218c - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv1218c gene Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs (PubMed:20921309, PubMed:23143285). Could be involved in the efflux of substrates belonging to the diverse chemical classes of novobiocins, biarylpiperazines, pyridines, bisanilinopyrimidines, pyrroles and, to a smaller extent, pyrazolones (PubMed:20921309). Probably responsible for energy coupling to the transport system (Probable). Indicus|evm.model.PRDE01216331.1.64 P19642 PTOCB_ECOLI 54.867 0.388824 1.62075 malX - PTS system maltose-specific EIICB component - Escherichia coli (strain K12) - malX gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in maltose transport. MalX can also recognize and transport glucose even though this sugar may not represent the natural substrate of the system. Indicus|evm.model.PRDE01216331.1.66 Q03H73 PHK_PEDPA 90.712 0.996193 1.00127 PEPE_0353 - Probable phosphoketolase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - PEPE_0353 gene Indicus|evm.model.PRDE01216331.1.68 Q07211 SCRK_STRMU 57.732 0.979381 0.993174 scrK - Fructokinase - Streptococcus mutans serotype c (strain ATCC 700610 / UA159) - scrK gene Indicus|evm.model.PRDE01216331.1.71 O34948 YKWC_BACSU 48.070 0.986111 1 ykwC - Uncharacterized oxidoreductase YkwC - Bacillus subtilis (strain 168) - ykwC gene Indicus|evm.model.PRDE01216331.1.78 Q03H60 FENR_PEDPA 69.967 0.993421 0.926829 PEPE_0366 - Ferredoxin--NADP reductase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - PEPE_0366 gene Indicus|evm.model.PRDE01216331.1.79 Q797B3 LTAS1_BACSU 51.220 0.897436 0.85446 ltaS1 - Lipoteichoic acid synthase 1 - Bacillus subtilis (strain 168) - ltaS1 gene Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate. Indicus|evm.model.PRDE01216331.1.81 P19994 MAP11_BACSU 46.586 0.306173 3.26613 map - Methionine aminopeptidase 1 - Bacillus subtilis (strain 168) - map gene Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. Indicus|evm.model.PRDE01216331.1.84 O32210 GR_BACSU 51.786 0.982394 1.02899 yvgN - Glyoxal reductase - Bacillus subtilis (strain 168) - yvgN gene Reduces glyoxal and methylglyoxal (2-oxopropanal). Is not involved in the vitamin B6 biosynthesis. Indicus|evm.model.PRDE01216331.1.85 Q03H46 PEPX_PEDPA 81.129 0.648649 1.27586 pepX - Xaa-Pro dipeptidyl-peptidase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - pepX gene Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Indicus|evm.model.PRDE01216331.1.86 Q797A7 MTRTR_BACSU 51.087 0.984881 1.00434 mtrA - Methylthioribose transporter - Bacillus subtilis (strain 168) - mtrA gene Involved in import of methylthioribose (MTR) into the cell. Indicus|evm.model.PRDE01216331.1.90 P27675 GLNQ_GEOSE 61.475 0.983806 1.02066 glnQ - Glutamine transport ATP-binding protein GlnQ - Geobacillus stearothermophilus - glnQ gene Part of the binding-protein-dependent transport system for glutamine. Probably responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01216331.1.91 P27676 GLNH_GEOSE 56.548 0.755656 0.843511 glnH - Glutamine-binding protein precursor - Geobacillus stearothermophilus - glnH gene Involved in glutamine-transport system. Interacts with the glutamine-transport system GlnPQ. Indicus|evm.model.PRDE01216331.1.92 O34671 GLNM_BACSU 59.394 0.453039 1.67593 glnM - Probable glutamine ABC transporter permease protein GlnM - Bacillus subtilis (strain 168) - glnM gene Part of the ABC transporter complex GlnHMPQ involved in glutamine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity). Indicus|evm.model.PRDE01216331.1.97 Q04789 ILVX_BACSU 52.813 0.982111 0.980702 alsS - Acetolactate synthase - Bacillus subtilis (strain 168) - alsS gene acetolactate synthase complex, acetolactate synthase activity, flavin adenine dinucleotide binding, isoleucine biosynthetic process, valine biosynthetic process Indicus|evm.model.PRDE01216331.1.99 Q03PP4 COAA_LACBA 63.000 0.977124 0.996743 coaA - Pantothenate kinase - Lactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947) - coaA gene Indicus|evm.model.PRDE01216331.1.100 Q6HDR9 TCYP_BACHK 49.471 0.981771 0.827586 BT9727_3988 - L-cystine uptake protein TcyP - Bacillus thuringiensis subsp. konkukian (strain 97-27) - BT9727_3988 gene Mediates uptake of L-cystine, the oxidized form of L-cysteine. Indicus|evm.model.PRDE01216331.1.104 Q03H14 GUAA_PEDPA 94.614 0.995327 0.827853 guaA - GMP synthase [glutamine-hydrolyzing] - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - guaA gene Catalyzes the synthesis of GMP from XMP. Indicus|evm.model.PRDE01216331.1.107 Q10730 AMPN_LACHE 63.808 0.359909 2.60071 pepN - Aminopeptidase N - Lactobacillus helveticus - pepN gene Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation. Indicus|evm.model.PRDE01216331.1.110 Q03H05 CH60_PEDPA 95.420 0.373838 2.59555 groL - 60 kDa chaperonin - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - groL gene Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Indicus|evm.model.PRDE01216331.1.111 Q03GZ8 SECA1_PEDPA 91.741 0.997462 1.00254 secA1 - Protein translocase subunit SecA 1 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - secA1 gene Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Indicus|evm.model.PRDE01216331.1.112 Q88YL5 RF2_LACPL 71.988 0.993994 0.883289 prfB - Peptide chain release factor 2 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - prfB gene Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. Indicus|evm.model.PRDE01216331.1.113 P13792 PHOP_BACSU 50.000 0.956522 0.766667 phoP - Alkaline phosphatase synthesis transcriptional regulatory protein PhoP - Bacillus subtilis (strain 168) - phoP gene Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase. Indicus|evm.model.PRDE01216331.1.115 Q8DZV4 PSTS1_STRA5 55.056 0.901361 1.02083 pstS1 - Phosphate-binding protein PstS 1 precursor - Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) - pstS1 gene Part of the ABC transporter complex PstSACB involved in phosphate import. Indicus|evm.model.PRDE01216331.1.117 Q1WUX2 PSTB1_LACS1 72.075 0.981413 1.01894 pstB1 - Phosphate import ATP-binding protein PstB 1 - Lactobacillus salivarius (strain UCC118) - pstB1 gene Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01216331.1.118 Q1WUX1 PSTB2_LACS1 66.837 0.503876 1.54183 pstB2 - Phosphate import ATP-binding protein PstB 2 - Lactobacillus salivarius (strain UCC118) - pstB2 gene Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01216331.1.119 Q03GY5 HPRK_PEDPA 87.773 0.464358 1.57372 hprK - HPr kinase/phosphorylase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - hprK gene Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion. Indicus|evm.model.PRDE01216331.1.120 Q03GY3 GPDA_PEDPA 90.820 0.993464 0.905325 gpsA - Glycerol-3-phosphate dehydrogenase [NAD(P)+] - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - gpsA gene Indicus|evm.model.PRDE01216331.1.121 P58313 CAP4C_STRPN 70.677 0.988636 0.882943 cap4C - UTP--glucose-1-phosphate uridylyltransferase - Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) - cap4C gene Indicus|evm.model.PRDE01216331.1.122 O32823 TRXB_LISMO 59.794 0.989726 0.915361 trxB - Thioredoxin reductase - Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) - trxB gene Indicus|evm.model.PRDE01216331.1.123 P18159 PGCA_BACSU 45.624 0.994382 0.919105 pgcA - Phosphoglucomutase - Bacillus subtilis (strain 168) - pgcA gene Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). Has a role in the biosynthesis of all phosphate-containing envelope polymers, since glucose-1-phosphate is the precursor of UDP-glucose, which serves as a glucosyl donor not only for the biosynthesis of LTA but also for wall teichoic acids (WTAs). Is required for biofilm formation. This is likely due to another role of UDP-glucose, which might also act as a metabolic signal regulating biofilm formation or may be involved in some unknown biosynthetic pathway essential for biofilm formation, e.g. the synthesis of an exopolysaccharide. Indicus|evm.model.PRDE01216331.1.125 Q88YI8 UVRB_LACPL 81.381 0.995509 1.0015 uvrB - UvrABC system protein B - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - uvrB gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage. Indicus|evm.model.PRDE01216331.1.126 Q88YI7 UVRA_LACPL 81.443 0.992036 0.92429 uvrA - UvrABC system protein A - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - uvrA gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Indicus|evm.model.PRDE01216331.1.127 Q03GX6 Y450_PEDPA 79.853 0.468966 1.9661 PEPE_0450 - Nucleotide-binding protein PEPE_0450 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - PEPE_0450 gene Displays ATPase and GTPase activities. Indicus|evm.model.PRDE01216331.1.128 Q03GX4 WHIA_PEDPA 91.549 0.992982 0.92233 whiA - Probable cell division protein WhiA - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - whiA gene Involved in cell division and chromosome segregation. Indicus|evm.model.PRDE01216331.1.130 Q03GX1 CLPP_PEDPA 97.462 0.989899 1.00508 clpP - ATP-dependent Clp protease proteolytic subunit - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - clpP gene Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Indicus|evm.model.PRDE01216331.1.133 O32755 G3P_LACDE 81.471 0.994135 1.00888 gap - Glyceraldehyde-3-phosphate dehydrogenase - Lactobacillus delbrueckii subsp. bulgaricus - gap gene Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. Indicus|evm.model.PRDE01216331.1.134 Q03GW7 PGK_PEDPA 96.021 0.59588 1.5775 pgk - Phosphoglycerate kinase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - pgk gene Indicus|evm.model.PRDE01216331.1.135 Q03GW5 ENO_PEDPA 96.818 0.995465 1.00227 eno - Enolase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - eno gene Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. Indicus|evm.model.PRDE01216331.1.136 Q9CH00 RNR1_LACLA 46.165 0.908163 0.959608 rnr1 - Ribonuclease R 1 - Lactococcus lactis subsp. lactis (strain IL1403) - rnr1 gene 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Indicus|evm.model.PRDE01216331.1.137 Q03GW2 SSRP_PEDPA 87.500 0.984496 0.832258 smpB - SsrA-binding protein - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - smpB gene Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. Indicus|evm.model.PRDE01216331.1.142 Q03GV8 UNG_PEDPA 89.418 0.989474 0.826087 ung - Uracil-DNA glycosylase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - ung gene Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Indicus|evm.model.PRDE01216331.1.143 O05515 TSAE_BACSU 50.370 0.905405 0.936709 tsaE - tRNA threonylcarbamoyladenosine biosynthesis protein TsaE - Bacillus subtilis (strain 168) - tsaE gene Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB; this reaction does not require ATP in vitro. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. Displays ATPase activity in vitro, which is modulated by the oligomeric status of the protein. Indicus|evm.model.PRDE01216331.1.146 Q03GV3 MURB_PEDPA 87.037 0.990783 0.723333 murB - UDP-N-acetylenolpyruvoylglucosamine reductase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - murB gene Cell wall formation. Indicus|evm.model.PRDE01216331.1.147 Q45589 CDAA_BACSU 66.480 0.374207 1.7326 cdaA - Cyclic di-AMP synthase CdaA - Bacillus subtilis (strain 168) - cdaA gene One of 3 paralogous diadenylate cyclases (DAC) in this bacteria, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (Probable). Upon expression in E.coli leads to c-di-AMP synthesis (PubMed:23192352). Probably the main producer of c-di-AMP for the cell; is probably implicated in control of peptidogylcan synthesis (PubMed:22211522, PubMed:23192352, PubMed:26240071). In B.subtilis c-di-AMP is a second messenger that mediates growth, DNA repair and cell wall homeostasis; it is toxic when present in excess (PubMed:26240071). Indicus|evm.model.PRDE01216331.1.148 Q03GV0 GLMM_PEDPA 93.899 0.994709 0.836283 glmM - Phosphoglucosamine mutase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - glmM gene Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. Indicus|evm.model.PRDE01216331.1.149 Q88YE7 GLMS_LACPL 65.182 0.9967 1.00165 glmS - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - glmS gene Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Indicus|evm.model.PRDE01216331.1.156 P37083 PTRD_KLEPN 48.760 0.268456 1.63139 sorM - PTS system sorbose-specific EIID component - Klebsiella pneumoniae - sorM gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II SorABFM PTS system is involved in sorbose transport. Indicus|evm.model.PRDE01216331.1.158 O07006 PADC_BACSU 71.875 0.544521 1.81366 padC - Phenolic acid decarboxylase PadC - Bacillus subtilis (strain 168) - padC gene Involved in the decarboxylation and detoxification of phenolic derivatives. It is able to catalyze the decarboxylation of ferulic, p-coumaric and caffeic acids. Indicus|evm.model.PRDE01216331.1.160 P12310 DHG_BACSU 61.686 0.988593 1.00766 gdh - Glucose 1-dehydrogenase - Bacillus subtilis (strain 168) - gdh gene oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Indicus|evm.model.PRDE01216331.1.161 Q817I8 SYN_BACCR 65.659 0.958506 1.04104 asnS - Asparagine--tRNA ligase - Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711) - asnS gene Indicus|evm.model.PRDE01216331.1.166 Q9CIV4 PEPDA_LACLA 56.798 0.974026 1.00654 pepDA - Probable dipeptidase A - Lactococcus lactis subsp. lactis (strain IL1403) - pepDA gene Indicus|evm.model.PRDE01216331.1.168 P9WGT1 HSD_MYCTU 45.306 0.979757 0.95 fabG3 - 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - fabG3 gene Probably involved in steroid metabolism. Catalyzes the oxidation of androsterone (3alpha-hydroxy-5alpha-androstan-17-one) and 20beta-hydroxyprogesterone (4-pregnen-20beta-ol-3-one), and the reduction of progesterone (4-pregnen-3,20-dione). Shows a preference for NADH. Has no detectable activity for oxidation of L-3-hydroxybutyric acid and only an insignificant activity for reduction of acetoacetyl-CoA. Indicus|evm.model.PRDE01216331.1.169 P07071 NRDD_BPT4 50.836 0.856522 1.1405 nrdD - Anaerobic ribonucleoside-triphosphate reductase - Enterobacteria phage T4 - nrdD gene Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair. Indicus|evm.model.PRDE01216331.1.170 Q9CM94 NRDG_PASMU 45.833 0.863354 1.01899 nrdG - Anaerobic ribonucleoside-triphosphate reductase-activating protein - Pasteurella multocida (strain Pm70) - nrdG gene Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. Indicus|evm.model.PRDE01216331.1.171 P80866 SUFC_BACSU 65.104 0.366795 1.98467 sufC - Vegetative protein 296 - Bacillus subtilis (strain 168) - sufC gene Indicus|evm.model.PRDE01216331.1.172 Q9K7A0 CSD_BACHD 46.739 0.978667 0.923645 csd - Probable cysteine desulfurase - Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) - csd gene Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. Indicus|evm.model.PRDE01216335.1.1 Q0BWN5 FABA_HYPNA 69.375 0.935294 0.923913 fabA - 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase - Hyphomonas neptunium (strain ATCC 15444) - fabA gene Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. Indicus|evm.model.PRDE01216345.1.1 Q9UT97 PSA5_SCHPO 48.101 0.882022 0.720648 pup2 - Probable proteasome subunit alpha type-5 - Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) - pup2 gene The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). Indicus|evm.model.PRDE01216347.1.1 Q936X2 ATZF_PSESD 57.447 0.403509 0.18843 atzF - Allophanate hydrolase - Pseudomonas sp. (strain ADP) - atzF gene Hydrolyzes allophanate to NH(3) and CO(2). Can also use malonamate, but with much lower efficiency. Indicus|evm.model.PRDE01216357.1.2 A4XV44 SELU_PSEMY 78.386 0.980114 0.9437 selU - tRNA 2-selenouridine synthase - Pseudomonas mendocina (strain ymp) - selU gene Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. Indicus|evm.model.PRDE01216357.1.3 Q9I383 SELD_PSEAE 85.714 0.914439 1.08721 selD - Selenide, water dikinase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - selD gene Synthesizes selenophosphate from selenide and ATP. Indicus|evm.model.PRDE01216361.1.1 P40984 UBC9_SCHPO 65.672 0.965517 0.369427 hus5 - SUMO-conjugating enzyme ubc9 - Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) - hus5 gene Catalyzes the covalent attachment of ubiquitin-like protein SUMO/Smt3 to other proteins. Required for efficient recovery from DNA damage or S-phase arrest and normal mitosis. This may be as part of a checkpoint independent recovery process. Indicus|evm.model.PRDE01216364.1.5 A4XWN5 PUR5_PSEMY 94.753 0.43414 2.11364 purM - Phosphoribosylformylglycinamidine cyclo-ligase - Pseudomonas mendocina (strain ymp) - purM gene Indicus|evm.model.PRDE01216364.1.7 A8AD95 HDA_CITK8 51.304 0.398246 2.36515 hda - DnaA regulatory inactivator Hda - Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) - hda gene Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity). Indicus|evm.model.PRDE01216364.1.8 Q9I509 NQOR_PSEAE 85.876 0.619718 1.43434 PA0949 - NAD(P)H dehydrogenase (quinone) - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA0949 gene NAD(P)H dehydrogenase (quinone) activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, cellular response to oxidative stress Indicus|evm.model.PRDE01216364.1.9 P76569 YFGD_ECOLI 59.130 0.957627 0.991597 yfgD - Uncharacterized protein YfgD - Escherichia coli (strain K12) - yfgD gene cytosol Indicus|evm.model.PRDE01216364.1.10 A4VNB9 Y2825_PSEU5 95.854 0.995134 1.00244 PST_2825 - UPF0761 membrane protein PST_2825 - Pseudomonas stutzeri (strain A1501) - PST_2825 gene Indicus|evm.model.PRDE01216364.1.15 A4VNB4 SYP_PSEU5 95.447 0.996503 1.00175 proS - Proline--tRNA ligase - Pseudomonas stutzeri (strain A1501) - proS gene Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS. Indicus|evm.model.PRDE01216364.1.16 P32722 PORD_PSEAE 45.022 0.995338 0.968397 oprD - Porin D precursor - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - oprD gene Porin with a specificity for basic amino acids. Also possesses serine protease activity. Indicus|evm.model.PRDE01216364.1.17 A4VNB1 SLYX_PSEU5 72.727 0.346154 2.56338 slyX - Protein SlyX homolog - Pseudomonas stutzeri (strain A1501) - slyX gene Indicus|evm.model.PRDE01216364.1.18 P0A357 CSPB_LISMO 62.903 0.342697 2.69697 cspLB - Cold shock-like protein CspLB - Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) - cspLB gene cytosol, nucleic acid binding, RNA binding, transcription antitermination factor activity, RNA binding, negative regulation of DNA-templated transcription, termination, regulation of gene expression, regulation of mRNA stability Indicus|evm.model.PRDE01216364.1.19 P73321 Y1894_SYNY3 58.940 0.955414 1.00641 slr1894 - Protein slr1894 - Synechocystis sp. (strain PCC 6803 / Kazusa) - slr1894 gene Indicus|evm.model.PRDE01216371.1.1 Q09049 CYDA_AZOVI 81.964 0.940952 0.977654 cydA - Cytochrome bd ubiquinol oxidase subunit 1 - Azotobacter vinelandii - cydA gene May be involved in maintaining the low intracellular oxygen concentration required for nitrogen fixation. Indicus|evm.model.PRDE01216383.1.1 P39853 CAPD_STAAU 45.327 0.881497 0.803005 capD - Capsular polysaccharide biosynthesis protein CapD - Staphylococcus aureus - capD gene Required for the biosynthesis of type 1 capsular polysaccharide. Indicus|evm.model.PRDE01216393.1.1 P77851 HBD_THETC 71.429 0.989474 0.676157 hbd - 3-hydroxybutyryl-CoA dehydrogenase - Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) - hbd gene Indicus|evm.model.PRDE01216395.1.2 B3H5Q1 BGL11_ARATH 47.857 0.285115 0.915547 BGLU11 - Beta-glucosidase 11 precursor - Arabidopsis thaliana (Mouse-ear cress) - BGLU11 gene beta-glucosidase activity Indicus|evm.model.PRDE01216395.1.3 P42403 BGLC_BACSU 46.222 0.955556 0.471698 bglC - Aryl-phospho-beta-D-glucosidase BglC - Bacillus subtilis (strain 168) - bglC gene Is able to catalyze the hydrolysis of aryl-phospho-beta-D-glucosides such as 4-methylumbelliferyl-phospho-beta-D-glucopyranoside (MUG-P), phosphoarbutin and phosphosalicin. Is not essential for growth on arbutin and salicin as the sole carbon source. Indicus|evm.model.PRDE01216395.1.8 P23355 PTFBC_XANCP 45.685 0.873303 0.381034 fruA - PTS system fructose-specific EIIB'BC component - Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) - fruA gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. Indicus|evm.model.PRDE01216395.1.14 O52733 XYLT_LACBR 48.696 0.292149 1.70022 xylT - D-xylose transporter - Lactobacillus brevis - xylT gene Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Transport is driven by the proton motive force generated by either malolactic fermentation or by the metabolism of D-glucose. Indicus|evm.model.PRDE01216395.1.15 Q9S469 ARAD_GEOSE 58.525 0.93913 1.00877 araD - L-ribulose-5-phosphate 4-epimerase - Geobacillus stearothermophilus - araD gene Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). Indicus|evm.model.PRDE01216395.1.16 Q03HQ0 ARAA_PEDPA 91.507 0.995763 0.995781 araA - L-arabinose isomerase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - araA gene Catalyzes the conversion of L-arabinose to L-ribulose. Indicus|evm.model.PRDE01216395.1.17 Q6GGW9 DHA1_STAAR 68.466 0.514749 1.82258 ald1 - Alanine dehydrogenase 1 - Staphylococcus aureus (strain MRSA252) - ald1 gene May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer. Indicus|evm.model.PRDE01216395.1.18 Q48841 PEPD_LACSK 70.479 0.463535 1.71036 Probable dipeptidase - Lactobacillus sakei Indicus|evm.model.PRDE01216395.1.24 C1CU77 FUCI_STRZT 69.381 0.996466 0.962585 fucI - L-fucose isomerase - Streptococcus pneumoniae (strain Taiwan19F-14) - fucI gene Converts the aldose L-fucose into the corresponding ketose L-fuculose. Indicus|evm.model.PRDE01216395.1.26 A2VDF0 FUCM_HUMAN 49.664 0.97973 0.961039 FUOM - Fucose mutarotase - Homo sapiens (Human) - FUOM gene Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. Indicus|evm.model.PRDE01216395.1.28 Q59477 DHAT_KLEPN 59.605 0.975138 0.935401 dhaT - 1,3-propanediol dehydrogenase - Klebsiella pneumoniae - dhaT gene Indicus|evm.model.PRDE01216395.1.33 Q88S49 RHAB_LACPL 80.372 0.967936 1.02254 rhaB - Rhamnulokinase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - rhaB gene Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. Indicus|evm.model.PRDE01216395.1.34 Q88S51 RHAA_LACPL 79.747 0.991758 0.852459 rhaA - L-rhamnose isomerase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - rhaA gene Indicus|evm.model.PRDE01216395.1.35 Q88S52 RHAD_LACPL 76.680 0.980545 0.908127 rhaD - Rhamnulose-1-phosphate aldolase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - rhaD gene Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. Indicus|evm.model.PRDE01216395.1.38 O05508 GMUD_BACSU 50.324 0.984848 0.993548 gmuD - 6-phospho-beta-glucosidase GmuD - Bacillus subtilis (strain 168) - gmuD gene Phospho-beta-D-glucosidase that seems to be involved in the degradation of glucomannan. Is also capable of hydrolyzing aryl-phospho-beta-D-glucosides, although very weakly, and plays only a minor role, if any, in the degradation of these substrates in vivo. Indicus|evm.model.PRDE01216395.1.44 A0A0I9QGZ2 TKT_GEOSE 53.303 0.989062 0.958084 tkt - Transketolase - Geobacillus stearothermophilus - tkt gene Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, likely via a covalent intermediate with the cofactor thiamine pyrophosphate. Can use L-erythrulose as donor and D-ribose-5-phosphate as acceptor substrates, forming glycolaldehyde and D-sedoheptulose-7-phosphate. For synthetic purposes, is able to use hydroxypyruvate (HPA) as donor substrate, making the reaction irreversible due to the release of carbon dioxide, and various aldehydes as acceptor substrates, which leads to the corresponding ketoses. Thus, using hydroxypyruvate as donor and three different aldehydes as acceptors, i.e. glycolaldehyde, D-glyceraldehyde and butyraldehyde, the enzyme stereoselectively forms the corresponding products L-erythrulose, D-xylulose and (3S)-1,3-dihydroxyhexan-2-one, respectively. Indicus|evm.model.PRDE01216395.1.48 Q03PA4 MALEP_LACBA 46.130 0.983713 0.902941 LVIS_1908 - Maltose epimerase - Lactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947) - LVIS_1908 gene Catalyzes the interconversion of alpha and beta anomers of maltose. Indicus|evm.model.PRDE01216395.1.49 P23936 LACY_STRTR 55.897 0.984797 0.933754 lacS - Lactose permease - Streptococcus thermophilus - lacS gene Responsible for transport of beta-galactosides into the cell, with the concomitant uptake of protons (symport system), and also for transport of homologous and heterologous exchange of beta-galactosides. Indicus|evm.model.PRDE01216395.1.50 Q02603 BGAL_LEULA 80.097 0.731043 1.34824 lacL - Beta-galactosidase large subunit - Leuconostoc lactis - lacL gene Indicus|evm.model.PRDE01216395.1.51 Q88SE8 GAL1_LACPL 90.698 0.994845 1.00258 galK - Galactokinase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - galK gene Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Indicus|evm.model.PRDE01216395.1.52 O84903 GALE_LACCA 72.948 0.993939 0.996979 galE - UDP-glucose 4-epimerase - Lactobacillus casei - galE gene Indicus|evm.model.PRDE01216395.1.53 Q03HL3 GALT_PEDPA 89.278 0.991803 1.00412 galT - Galactose-1-phosphate uridylyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - galT gene Indicus|evm.model.PRDE01216395.1.55 A2RL65 ACAP_LACLM 62.976 0.986301 0.597137 acaP - Aspartate/glutamate permease AcaP - Lactococcus lactis subsp. cremoris (strain MG1363) - acaP gene Involved in aspartate and glutamate uptake. Plays no significant role in the excretion of accumulated glutamate. Indicus|evm.model.PRDE01216395.1.57 O94315 YH5B_SCHPO 45.185 0.937282 0.937908 SPBC215.11c - Uncharacterized oxidoreductase C215.11c - Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) - SPBC215.11c gene cytosol, nucleus Indicus|evm.model.PRDE01216395.1.58 Q03GE2 SYR_PEDPA 88.434 0.996448 1.00178 argS - Arginine--tRNA ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - argS gene Indicus|evm.model.PRDE01216395.1.62 A0AKX3 YHAM_LISW6 47.157 0.983498 0.968051 yhaM - 3'-5' exoribonuclease YhaM - Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8) - yhaM gene Shows a 3'-5' exoribonuclease activity. Indicus|evm.model.PRDE01216395.1.63 Q03GD4 PRSA_PEDPA 86.525 0.982517 0.969492 prsA - Foldase protein PrsA precursor - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - prsA gene Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Indicus|evm.model.PRDE01216395.1.64 O07513 HIT_BACSU 51.429 0.965278 0.993103 hit - Protein hit - Bacillus subtilis (strain 168) - hit gene nucleotide metabolic process Indicus|evm.model.PRDE01216395.1.65 P55339 ECSA_BACSU 54.595 0.958333 0.777328 ecsA - ABC-type transporter ATP-binding protein EcsA - Bacillus subtilis (strain 168) - ecsA gene Has a role in exoprotein production, sporulation and competence. Indicus|evm.model.PRDE01216395.1.66 O34943 YTPR_BACSU 48.571 0.5387 1.60697 ytpR - Putative tRNA-binding protein YtpR - Bacillus subtilis (strain 168) - ytpR gene Indicus|evm.model.PRDE01216395.1.67 C0SP86 SFTA_BACSU 57.114 0.704579 0.711134 sftA - DNA translocase SftA - Bacillus subtilis (strain 168) - sftA gene Required for the accurate completion of chromosome partitioning, in part by promoting efficient resolution of chromosome dimers, before the formation of the division septum. Binds to DNA in a non-specific manner. Shows ATPase activity. Not required for cytokinesis. Indicus|evm.model.PRDE01216395.1.68 Q03GC5 MURC_PEDPA 83.571 0.990544 0.970183 murC - UDP-N-acetylmuramate--L-alanine ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - murC gene Cell wall formation. Indicus|evm.model.PRDE01216395.1.70 O32801 DPO1_LACLM 54.392 0.995485 1.01026 polA - DNA polymerase I - Lactococcus lactis subsp. cremoris (strain MG1363) - polA gene In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. Indicus|evm.model.PRDE01216395.1.71 Q03GC2 FPG_PEDPA 78.855 0.420074 1.95636 mutM - Formamidopyrimidine-DNA glycosylase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - mutM gene Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Indicus|evm.model.PRDE01216395.1.74 Q03GB7 SYT_PEDPA 84.853 0.996914 1 thrS - Threonine--tRNA ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - thrS gene Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). Indicus|evm.model.PRDE01216395.1.75 Q8CR79 LYTS_STAES 50.546 0.608696 1.01184 lytS - Sensor protein LytS - Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) - lytS gene Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. Indicus|evm.model.PRDE01216395.1.76 Q88WU8 IF3_LACPL 78.916 0.463483 2.0578 infC - Translation initiation factor IF-3 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - infC gene IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. Indicus|evm.model.PRDE01216395.1.78 Q9CGJ7 NADD_LACLA 60.215 0.0962343 4.90256 nadD - Probable nicotinate-nucleotide adenylyltransferase - Lactococcus lactis subsp. lactis (strain IL1403) - nadD gene Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). Indicus|evm.model.PRDE01216395.1.79 Q03GA1 TMCAL_PEDPA 56.845 0.973529 0.928962 tmcAL - tRNA(Met) cytidine acetate ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - tmcAL gene Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. Indicus|evm.model.PRDE01216395.1.81 Q9CHU6 6PGD_LACLA 72.458 0.993658 1.00212 gnd - 6-phosphogluconate dehydrogenase, decarboxylating - Lactococcus lactis subsp. lactis (strain IL1403) - gnd gene Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Indicus|evm.model.PRDE01216395.1.82 P0C001 ARLR_STAAW 53.744 0.9869 1.04566 arlR - Response regulator ArlR - Staphylococcus aureus (strain MW2) - arlR gene Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. Indicus|evm.model.PRDE01216395.1.85 Q88WR2 SYFB_LACPL 55.198 0.739688 1.35528 pheT - Phenylalanine--tRNA ligase beta subunit - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - pheT gene Indicus|evm.model.PRDE01216395.1.87 B2G882 URK_LACRJ 73.585 0.946108 0.766055 udk - Uridine kinase - Lactobacillus reuteri (strain JCM 1112) - udk gene Indicus|evm.model.PRDE01216395.1.88 B2GD90 GREA_LACF3 70.667 0.967532 0.974684 greA - Transcription elongation factor GreA - Lactobacillus fermentum (strain NBRC 3956 / LMG 18251) - greA gene Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. Indicus|evm.model.PRDE01216395.1.91 P54495 GLK_BACSU 47.756 0.695067 1.38941 glcK - Glucokinase - Bacillus subtilis (strain 168) - glcK gene glucokinase activity Indicus|evm.model.PRDE01216395.1.92 Q03G75 MIAA_PEDPA 66.997 0.610101 1.59677 miaA - tRNA dimethylallyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - miaA gene Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). Indicus|evm.model.PRDE01216395.1.93 P45625 YGLN_BACCE 67.308 0.111354 5.725 Uncharacterized protein in glnR 5'region - Bacillus cereus Indicus|evm.model.PRDE01216395.1.94 P99095 GLN1A_STAAN 69.213 0.993088 0.973094 glnA - Glutamine synthetase - Staphylococcus aureus (strain N315) - glnA gene Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes. Indicus|evm.model.PRDE01216395.1.99 A7GSL5 EFP_BACCN 55.952 0.266773 3.38378 efp - Elongation factor P - Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) - efp gene Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. Indicus|evm.model.PRDE01216395.1.100 Q03FZ5 FOLD_PEDPA 70.671 0.703242 1.41696 folD - Bifunctional protein FolD - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - folD gene Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. Indicus|evm.model.PRDE01216395.1.101 Q03FZ4 EX7L_PEDPA 70.620 0.994624 0.832215 xseA - Exodeoxyribonuclease 7 large subunit - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - xseA gene Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. Indicus|evm.model.PRDE01216395.1.102 P80042 GGPPS_CAPAN 45.815 0.744966 0.807588 GGPS1 - Geranylgeranyl pyrophosphate synthase, chloroplastic precursor - Capsicum annuum (Capsicum pepper) - GGPS1 gene Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Indicus|evm.model.PRDE01216395.1.103 P19672 YQXC_BACSU 64.455 0.576923 1.29537 yqxC - Putative rRNA methyltransferase YqxC - Bacillus subtilis (strain 168) - yqxC gene Indicus|evm.model.PRDE01216395.1.104 Q9K974 RECN_BACHD 46.972 0.986965 0.950442 recN - DNA repair protein RecN - Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) - recN gene May be involved in recombinational repair of damaged DNA. Indicus|evm.model.PRDE01216395.1.105 Q1WUB5 KGUA_LACS1 75.879 0.99 0.97561 gmk - Guanylate kinase - Lactobacillus salivarius (strain UCC118) - gmk gene Essential for recycling GMP and indirectly, cGMP. Indicus|evm.model.PRDE01216395.1.107 P94461 PRIA_BACSU 47.309 0.997159 0.874534 priA - Primosomal protein N' - Bacillus subtilis (strain 168) - priA gene Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. Indicus|evm.model.PRDE01216395.1.108 Q03FY3 FMT_PEDPA 84.082 0.976 0.78125 fmt - Methionyl-tRNA formyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - fmt gene Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. Indicus|evm.model.PRDE01216395.1.110 Q03FX9 RSGA_PEDPA 76.744 0.390625 2.48544 rsgA - Small ribosomal subunit biogenesis GTPase RsgA - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rsgA gene One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. Indicus|evm.model.PRDE01216395.1.111 Q43843 RPE_SOLTU 51.685 0.504323 1.23929 Ribulose-phosphate 3-epimerase, chloroplastic precursor - Solanum tuberosum (Potato) Indicus|evm.model.PRDE01216395.1.112 Q49X07 Y1546_STAS1 49.225 0.996109 0.931159 SSP1546 - Uncharacterized protein SSP1546 - Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) - SSP1546 gene Indicus|evm.model.PRDE01216395.1.113 Q54900 RECG_STRPN 50.525 0.980769 1.00745 recG - ATP-dependent DNA helicase RecG - Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) - recG gene Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) (By similarity). Indicus|evm.model.PRDE01216395.1.114 Q03FX2 PLSX_PEDPA 86.095 0.160629 6.04611 plsX - Phosphate acyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - plsX gene Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. Indicus|evm.model.PRDE01216395.1.115 Q54431 SRP54_STRMU 64.764 0.899329 0.866279 ffh - Signal recognition particle protein - Streptococcus mutans serotype c (strain ATCC 700610 / UA159) - ffh gene Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Indicus|evm.model.PRDE01216395.1.116 Q03FW4 RIMM_PEDPA 67.251 0.7173 1.38596 rimM - Ribosome maturation factor RimM - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rimM gene An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes. Indicus|evm.model.PRDE01216395.1.117 Q03FW3 TRMD_PEDPA 89.316 0.991489 0.959184 trmD - tRNA (guanine-N(1)-)-methyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - trmD gene Specifically methylates guanosine-37 in various tRNAs. Indicus|evm.model.PRDE01216395.1.118 P77279 FETA_ECOLI 45.000 0.975155 0.715556 fetA - Probable iron export ATP-binding protein FetA - Escherichia coli (strain K12) - fetA gene Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for energy coupling to the transport system. Indicus|evm.model.PRDE01216395.1.119 Q03FW2 RL19_PEDPA 91.818 0.595628 1.53782 rplS - 50S ribosomal protein L19 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rplS gene This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. Indicus|evm.model.PRDE01216395.1.120 Q03QA0 Y1527_LACBA 82.524 0.962264 0.990654 LVIS_1527 - UPF0145 protein LVIS_1527 - Lactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947) - LVIS_1527 gene Indicus|evm.model.PRDE01216395.1.121 A8YXS0 FABH_LACH4 53.583 0.818182 1.17737 fabH - 3-oxoacyl-[acyl-carrier-protein] synthase 3 - Lactobacillus helveticus (strain DPC 4571) - fabH gene Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids. Indicus|evm.model.PRDE01216395.1.122 O67610 FABG_AQUAE 47.500 0.75974 1.24194 fabG - 3-oxoacyl-[acyl-carrier-protein] reductase FabG - Aquifex aeolicus (strain VF5) - fabG gene Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Indicus|evm.model.PRDE01216395.1.123 O34340 FABF_BACSU 50.500 0.995 0.968523 fabF - 3-oxoacyl-[acyl-carrier-protein] synthase 2 - Bacillus subtilis (strain 168) - fabF gene Involved in the type II fatty acid elongation cycle (PubMed:11325930). Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:11325930). Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition (By similarity). Indicus|evm.model.PRDE01216395.1.124 P49787 ACCC1_BACSU 54.382 0.971491 1.01333 accC1 - Biotin carboxylase 1 - Bacillus subtilis (strain 168) - accC1 gene This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. Indicus|evm.model.PRDE01216395.1.125 Q03FV0 ACCD_PEDPA 81.532 0.986547 0.807971 accD - Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - accD gene Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. Indicus|evm.model.PRDE01216395.1.126 Q03M45 ACCA_STRTD 56.504 0.983806 0.964844 accA - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha - Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) - accA gene Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. Indicus|evm.model.PRDE01216395.1.127 Q820V5 FABI_ENTFA 60.669 0.987552 0.964 fabI - Enoyl-[acyl-carrier-protein] reductase [NADH] FabI - Enterococcus faecalis (strain ATCC 700802 / V583) - fabI gene Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity). Indicus|evm.model.PRDE01216395.1.129 Q9FD71 HMGCS_ENTFL 50.299 0.889785 0.971279 mvaS - Hydroxymethylglutaryl-CoA synthase - Enterococcus faecalis - mvaS gene Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds. Indicus|evm.model.PRDE01216395.1.130 Q03FU3 LEXA_PEDPA 85.572 0.564972 1.69378 lexA - LexA repressor - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - lexA gene Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Indicus|evm.model.PRDE01216395.1.132 Q59642 LDHD_PEDAC 99.396 0.993976 1.00302 ldhD - D-lactate/D-glycerate dehydrogenase - Pediococcus acidilactici - ldhD gene Has both D-lactate and D-glycerate dehydrogenase activities. Equally active on pyruvate and hydroxypyruvate. Indicus|evm.model.PRDE01216395.1.133 P49668 RS2_PEDAC 100.000 0.991525 0.904215 rpsB - 30S ribosomal protein S2 - Pediococcus acidilactici - rpsB gene Indicus|evm.model.PRDE01216395.1.134 Q03FT5 EFTS_PEDPA 94.139 0.992701 0.938356 tsf - Elongation factor Ts - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - tsf gene Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Indicus|evm.model.PRDE01216395.1.135 Q03FT4 PYRH_PEDPA 95.169 0.542105 1.57676 pyrH - Uridylate kinase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - pyrH gene Catalyzes the reversible phosphorylation of UMP to UDP. Indicus|evm.model.PRDE01216395.1.136 Q88VJ8 UPPS_LACPL 62.911 0.981481 0.833977 uppS - Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - uppS gene Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. Indicus|evm.model.PRDE01216395.1.137 Q9RPP2 EEP_ENTFA 49.347 0.994751 0.902844 eep - Probable protease eep - Enterococcus faecalis (strain ATCC 700802 / V583) - eep gene Involved in production of the peptide pheromone cAD1. Indicus|evm.model.PRDE01216395.1.138 Q03FS8 DPO3_PEDPA 86.291 0.72695 1.3737 polC - DNA polymerase III PolC-type - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - polC gene Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. Indicus|evm.model.PRDE01216395.1.139 P32727 NUSA_BACSU 60.724 0.904884 1.04852 nusA - Transcription termination/antitermination protein NusA - Bacillus subtilis (strain 168) - nusA gene Participates in both transcription termination and antitermination. Indicus|evm.model.PRDE01216395.1.140 Q03FS3 IF2_PEDPA 91.615 0.735698 0.95207 infB - Translation initiation factor IF-2 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - infB gene One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. Indicus|evm.model.PRDE01216395.1.141 Q03FS2 RBFA_PEDPA 91.379 0.982906 1.00862 rbfA - Ribosome-binding factor A - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rbfA gene One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. Indicus|evm.model.PRDE01216395.1.142 Q03FS1 TRUB_PEDPA 74.653 0.99308 0.966555 truB - tRNA pseudouridine synthase B - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - truB gene Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. Indicus|evm.model.PRDE01216395.1.143 Q8Y7F2 RIBCF_LISMO 49.231 0.98855 0.834395 ribCF - Bifunctional riboflavin kinase/FMN adenylyltransferase - Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) - ribCF gene Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD (PubMed:27672192). Can also catalyze the phosphorylation of the toxic riboflavin analogs 8-demethyl-8-aminoriboflavin (AF) to 8-demethyl-8-aminoriboflavin mononucleotide (AFMN) and roseoflavin (RoF) to roseoflavin mononucleotide (RoFMN), and the adenylation of AFMN to 8-demethyl-8-aminoriboflavin adenine dinucleotide (AFAD) (PubMed:27672192). Indicus|evm.model.PRDE01216395.1.144 Q03FR9 HRCA_PEDPA 79.939 0.613936 1.53468 hrcA - Heat-inducible transcription repressor HrcA - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - hrcA gene Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. Indicus|evm.model.PRDE01216395.1.145 Q03FR7 DNAK_PEDPA 92.487 0.996661 0.96769 dnaK - Chaperone protein DnaK - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - dnaK gene Acts as a chaperone. Indicus|evm.model.PRDE01216395.1.146 Q03FR6 DNAJ_PEDPA 88.503 0.994667 1.00267 dnaJ - Chaperone protein DnaJ - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - dnaJ gene Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins. Indicus|evm.model.PRDE01216395.1.151 Q1WUE6 LEPA_LACS1 83.775 0.913636 1.08374 lepA - Elongation factor 4 - Lactobacillus salivarius (strain UCC118) - lepA gene Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. Indicus|evm.model.PRDE01216395.1.152 Q48841 PEPD_LACSK 45.796 0.995575 0.955603 Probable dipeptidase - Lactobacillus sakei Indicus|evm.model.PRDE01216395.1.155 Q038V3 IDI2_LACP3 51.880 0.920139 0.837209 fni - Isopentenyl-diphosphate delta-isomerase - Lactobacillus paracasei (strain ATCC 334 / BCRC 17002 / CIP 107868 / KCTC 3260 / NRRL B-441) - fni gene Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). Indicus|evm.model.PRDE01216395.1.160 Q03FN2 RECU_PEDPA 82.036 0.988095 0.835821 recU - Holliday junction resolvase RecU - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - recU gene Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation. Indicus|evm.model.PRDE01216395.1.161 Q03FN1 Y933_PEDPA 71.585 0.98913 1.00546 PEPE_0933 - UPF0398 protein PEPE_0933 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - PEPE_0933 gene Indicus|evm.model.PRDE01216395.1.162 Q03FN0 GPSB_PEDPA 92.035 0.982456 1.00885 gpsB - Cell cycle protein GpsB - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - gpsB gene Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. Indicus|evm.model.PRDE01216395.1.163 P50840 YPSC_BACSU 58.011 0.978261 0.955844 ypsC - Putative RNA methyltransferase YpsC - Bacillus subtilis (strain 168) - ypsC gene rRNA (guanine-N2-)-methyltransferase activity, rRNA (guanine-N7-)-methyltransferase activity Indicus|evm.model.PRDE01216395.1.165 Q03FM6 FTHS_PEDPA 81.982 0.996403 1.00542 fhs - Formate--tetrahydrofolate ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - fhs gene Indicus|evm.model.PRDE01216395.1.166 Q45480 YLYB_BACSU 61.000 0.980198 1 ylyB - Uncharacterized RNA pseudouridine synthase YlyB - Bacillus subtilis (strain 168) - ylyB gene pseudouridine synthase activity, enzyme-directed rRNA pseudouridine synthesis Indicus|evm.model.PRDE01216395.1.167 Q03FM3 PYRR_PEDPA 92.090 0.988764 1.00565 pyrR - Bifunctional protein PyrR - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - pyrR gene Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Indicus|evm.model.PRDE01216395.1.168 Q8DUP4 CARA_STRMU 49.296 0.977901 1 carA - Carbamoyl-phosphate synthase small chain - Streptococcus mutans serotype c (strain ATCC 700610 / UA159) - carA gene Indicus|evm.model.PRDE01216395.1.171 Q927X9 Y2658_LISIN 49.822 0.972222 1.01767 lin2658 - DegV domain-containing protein lin2658 - Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) - lin2658 gene May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. Indicus|evm.model.PRDE01216395.1.176 B0K0Y9 RIBBA_THEPX 54.192 0.973684 0.863636 ribBA - Riboflavin biosynthesis protein RibBA - Thermoanaerobacter sp. (strain X514) - ribBA gene Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. Indicus|evm.model.PRDE01216395.1.180 Q1WU33 MSRA_LACS1 75.796 0.987342 0.918605 msrA - Peptide methionine sulfoxide reductase MsrA - Lactobacillus salivarius (strain UCC118) - msrA gene Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Indicus|evm.model.PRDE01216395.1.182 Q88W32 PPAC_LACPL 67.961 0.619718 1.60841 ppaC - Probable manganese-dependent inorganic pyrophosphatase - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - ppaC gene Indicus|evm.model.PRDE01216395.1.183 Q45066 PARC_BACSU 54.396 0.973154 0.924318 parC - DNA topoisomerase 4 subunit A - Bacillus subtilis (strain 168) - parC gene Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Indicus|evm.model.PRDE01216395.1.184 H7C794 PARE_ENTFA 76.619 0.966361 0.954745 parE - DNA topoisomerase 4 subunit B - Enterococcus faecalis (strain ATCC 700802 / V583) - parE gene Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:23352267). Performs the decatenation events required during the replication of a circular DNA molecule. Indicus|evm.model.PRDE01216395.1.186 Q88W26 HSLU_LACPL 71.897 0.995305 0.902542 hslU - ATP-dependent protease ATPase subunit HslU - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - hslU gene ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. Indicus|evm.model.PRDE01216395.1.187 Q03FK3 HSLV_PEDPA 95.082 0.957895 1.03261 hslV - ATP-dependent protease subunit HslV - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - hslV gene Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. Indicus|evm.model.PRDE01216395.1.188 Q9CG80 TOP1_LACLA 66.256 0.996909 0.911268 topA - DNA topoisomerase 1 - Lactococcus lactis subsp. lactis (strain IL1403) - topA gene Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Indicus|evm.model.PRDE01216396.1.3 Q97QT7 Y1112_STRPN 47.200 0.984064 0.899642 SP_1112 - DegV domain-containing protein SP_1112 - Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) - SP_1112 gene May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. Indicus|evm.model.PRDE01216396.1.4 Q03F96 TYSY_PEDPA 87.025 0.993691 1.00316 thyA - Thymidylate synthase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - thyA gene Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. Indicus|evm.model.PRDE01216396.1.5 Q03F94 CCA_PEDPA 69.333 0.380081 2.48485 cca - CCA-adding enzyme - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - cca gene Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Indicus|evm.model.PRDE01216396.1.8 P0A3H0 DBH_GEOSE 75.000 0.157371 5.57778 hup - DNA-binding protein HU - Geobacillus stearothermophilus - hup gene Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Indicus|evm.model.PRDE01216396.1.9 Q03SA1 DER_LACBA 77.701 0.995413 1.0023 der - GTPase Der - Lactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947) - der gene GTPase that plays an essential role in the late steps of ribosome biogenesis. Indicus|evm.model.PRDE01216396.1.10 P50889 RS1_LEULA 53.165 0.962871 0.941725 rps1 - 30S ribosomal protein S1 - Leuconostoc lactis - rps1 gene Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity). Indicus|evm.model.PRDE01216396.1.11 Q03F87 KCY_PEDPA 79.365 0.989474 0.840708 cmk - Cytidylate kinase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - cmk gene Indicus|evm.model.PRDE01216396.1.12 P50729 RECS_BACSU 46.250 0.554783 1.15927 recS - Probable ATP-dependent DNA helicase RecS - Bacillus subtilis (strain 168) - recS gene Probable DNA helicase. Required in synaptic and/or post-synaptic stages of recombination. Probably has overlapping function with RecQ (AC O34748). It probably acts to help generate ss-DNA from ds-DNA breaks. Indicus|evm.model.PRDE01216396.1.13 P35159 RLUB_BACSU 59.471 0.9869 0.938525 rluB - Ribosomal large subunit pseudouridine synthase B - Bacillus subtilis (strain 168) - rluB gene Responsible for synthesis of pseudouridine from uracil-2633 in 23S ribosomal RNA. Indicus|evm.model.PRDE01216396.1.14 Q03F82 SCPB_PEDPA 70.968 0.423077 1.85714 scpB - Segregation and condensation protein B - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - scpB gene Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. Indicus|evm.model.PRDE01216396.1.15 Q03F74 PFKA_PEDPA 95.066 0.204453 4.60248 pfkA - ATP-dependent 6-phosphofructokinase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - pfkA gene Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Indicus|evm.model.PRDE01216396.1.17 Q88VX7 CLPB_LACPL 71.886 0.974508 0.995386 clpB - Chaperone protein ClpB - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - clpB gene Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Indicus|evm.model.PRDE01216396.1.20 P52329 SIGA_ENTFA 80.978 0.383001 2.58967 sigA - RNA polymerase sigma factor SigA - Enterococcus faecalis (strain ATCC 700802 / V583) - sigA gene Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Indicus|evm.model.PRDE01216396.1.21 Q03F66 SYGB_PEDPA 75.762 0.508936 1.86522 glyS - Glycine--tRNA ligase beta subunit - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - glyS gene Indicus|evm.model.PRDE01216396.1.22 Q03F61 YBEY_PEDPA 92.035 0.982456 0.730769 ybeY - Endoribonuclease YbeY - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - ybeY gene Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. Indicus|evm.model.PRDE01216396.1.23 P0A9K6 PHOL_SHIFL 60.714 0.539952 1.19364 ybeZ - PhoH-like protein - Shigella flexneri - ybeZ gene Indicus|evm.model.PRDE01216396.1.24 Q03F57 PDRP_PEDPA 78.731 0.988889 1.00372 PEPE_1110 - Putative pyruvate, phosphate dikinase regulatory protein - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - PEPE_1110 gene Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. Indicus|evm.model.PRDE01216396.1.25 Q03F56 END4_PEDPA 78.292 0.985915 0.959459 nfo - Probable endonuclease 4 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - nfo gene Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. Indicus|evm.model.PRDE01216396.1.28 Q03F52 SYD_PEDPA 92.230 0.994949 1.00169 aspS - Aspartate--tRNA ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - aspS gene Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp). Indicus|evm.model.PRDE01216396.1.29 Q03F51 SYH_PEDPA 82.199 0.994778 0.903302 hisS - Histidine--tRNA ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - hisS gene Indicus|evm.model.PRDE01216396.1.31 O54408 RELA_BACSU 56.772 0.877427 1.12262 relA - GTP pyrophosphokinase - Bacillus subtilis (strain 168) - relA gene In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp, it is probably the hydrolysis activity that is required for optimal growth (Probable). Indicus|evm.model.PRDE01216396.1.32 P54461 RSME_BACSU 48.864 0.792627 0.847656 rsmE - Ribosomal RNA small subunit methyltransferase E - Bacillus subtilis (strain 168) - rsmE gene Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity). Indicus|evm.model.PRDE01216396.1.33 Q03F44 PRMA_PEDPA 76.266 0.503205 1.97468 prmA - Ribosomal protein L11 methyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - prmA gene Methylates ribosomal protein L11. Indicus|evm.model.PRDE01216396.1.35 P27830 RMLB2_ECOLI 49.502 0.920886 0.890141 rffG - dTDP-glucose 4,6-dehydratase 2 - Escherichia coli (strain K12) - rffG gene Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. Indicus|evm.model.PRDE01216396.1.41 O33655 LA2M_STRIN 49.865 0.994565 0.913151 lctO - Lactate 2-monooxygenase - Streptococcus iniae - lctO gene Involved in the L-lactate aerobic metabolism. Indicus|evm.model.PRDE01216397.1.4 O32177 FADA_BACSU 46.701 0.992405 1.01023 fadA - 3-ketoacyl-CoA thiolase - Bacillus subtilis (strain 168) - fadA gene Involved in the degradation of long-chain fatty acids. Indicus|evm.model.PRDE01216399.1.1 Q9I048 DUSA_PSEAE 83.784 0.989933 0.89759 dusA - tRNA-dihydrouridine(20/20a) synthase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - dusA gene Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs. Indicus|evm.model.PRDE01216399.1.2 A4VK43 TAL_PSEU5 98.701 0.993528 1.00325 tal - Transaldolase - Pseudomonas stutzeri (strain A1501) - tal gene Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Indicus|evm.model.PRDE01216399.1.8 A4XTL9 QUEF_PSEMY 79.710 0.919732 1.08333 queF - NADPH-dependent 7-cyano-7-deazaguanine reductase - Pseudomonas mendocina (strain ymp) - queF gene Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Indicus|evm.model.PRDE01216399.1.9 P0AFN9 YADH_SHIFL 58.559 0.991031 0.871094 yadH - Inner membrane transport permease YadH - Shigella flexneri - yadH gene Indicus|evm.model.PRDE01216399.1.10 P36879 YADG_ECOLI 66.113 0.967742 1.00649 yadG - Uncharacterized ABC transporter ATP-binding protein YadG - Escherichia coli (strain K12) - yadG gene plasma membrane, response to X-ray Indicus|evm.model.PRDE01216399.1.11 A4XWE4 ASTE_PSEMY 48.729 0.957806 0.703264 astE - Succinylglutamate desuccinylase - Pseudomonas mendocina (strain ymp) - astE gene Transforms N(2)-succinylglutamate into succinate and glutamate. Indicus|evm.model.PRDE01216404.1.1 P30265 CATA_LACSK 69.401 0.982533 0.958159 katA - Catalase - Lactobacillus sakei - katA gene Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Indicus|evm.model.PRDE01216404.1.5 Q03F39 APT_PEDPA 83.333 0.153465 5.87209 apt - Adenine phosphoribosyltransferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - apt gene Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Indicus|evm.model.PRDE01216404.1.6 Q03F36 RNZ_PEDPA 82.468 0.993528 1.00325 rnz - Ribonuclease Z - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rnz gene Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Indicus|evm.model.PRDE01216404.1.7 Q03F34 OBG_PEDPA 87.935 0.99537 1.00465 obg - GTPase Obg - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - obg gene An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Indicus|evm.model.PRDE01216404.1.8 Q03F33 UVRC_PEDPA 90.702 0.991289 0.96633 uvrC - UvrABC system protein C - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - uvrC gene The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. Indicus|evm.model.PRDE01216404.1.9 Q03F28 ENGB_PEDPA 92.486 0.214197 4.11795 engB - Probable GTP-binding protein EngB - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - engB gene Necessary for normal cell division and for the maintenance of normal septation. Indicus|evm.model.PRDE01216404.1.10 Q03F27 CLPX_PEDPA 90.909 0.501202 1.99043 clpX - ATP-dependent Clp protease ATP-binding subunit ClpX - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - clpX gene ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. Indicus|evm.model.PRDE01216404.1.11 Q03F25 EFTU_PEDPA 96.203 0.994949 1.00253 tuf - Elongation factor Tu - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - tuf gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Indicus|evm.model.PRDE01216404.1.12 Q8K7S6 RNJ2_STRP3 51.894 0.74048 1.2821 rnj2 - Ribonuclease J 2 - Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) - rnj2 gene An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity). Has an overlapping but not completely redundant role with RNase J1 in the decay of mRNA. Indicus|evm.model.PRDE01216404.1.13 Q03F22 RS15_PEDPA 95.506 0.0938166 10.5393 rpsO - 30S ribosomal protein S15 - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rpsO gene One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. Indicus|evm.model.PRDE01216404.1.16 O07631 BIPA_BACSU 67.572 0.844828 1.13725 bipA - 50S ribosomal subunit assembly factor BipA - Bacillus subtilis (strain 168) - bipA gene A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA. Indicus|evm.model.PRDE01216404.1.17 Q03F09 DEF_PEDPA 90.055 0.989011 0.98913 def - Peptide deformylase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - def gene Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. Indicus|evm.model.PRDE01216404.1.18 Q8K5W8 RNJ1_STRP3 66.727 0.992844 0.998214 rnj1 - Ribonuclease J 1 - Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) - rnj1 gene An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity). Has an overlapping but not completely redundant role with RNase J2 in the decay of mRNA. Indicus|evm.model.PRDE01216404.1.19 P13692 P54_ENTFC 54.545 0.260638 0.728682 Protein P54 precursor - Enterococcus faecium Indicus|evm.model.PRDE01216404.1.20 P41029 PTFC_BACAM 52.577 0.465378 2.04276 fruA - Fructose permease IIC component - Bacillus amyloliquefaciens - fruA gene The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in fructose transport (By similarity). Indicus|evm.model.PRDE01216404.1.22 Q88VA5 KPRS2_LACPL 66.531 0.513684 1.47975 prs2 - Putative ribose-phosphate pyrophosphokinase 2 - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - prs2 gene Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). Indicus|evm.model.PRDE01216404.1.26 Q03EZ6 MNMA_PEDPA 94.247 0.994536 0.970822 mnmA - tRNA-specific 2-thiouridylase MnmA - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - mnmA gene Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. Indicus|evm.model.PRDE01216404.1.27 O34599 ISCS1_BACSU 53.506 0.960854 0.741425 iscS1 - Putative cysteine desulfurase IscS 1 - Bacillus subtilis (strain 168) - iscS1 gene Catalyzes the removal of elemental sulfur from cysteine to produce alanine. Indicus|evm.model.PRDE01216404.1.28 A5ITC6 MTNN_STAA9 48.113 0.929515 0.995614 mtnN - 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase - Staphylococcus aureus (strain JH9) - mtnN gene Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Indicus|evm.model.PRDE01216404.1.30 Q03EY9 SYI_PEDPA 85.512 0.997824 0.984995 ileS - Isoleucine--tRNA ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - ileS gene Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Indicus|evm.model.PRDE01216404.1.32 Q9K9T7 FTSZ_BACHD 69.355 0.707094 1.14398 ftsZ - Cell division protein FtsZ - Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) - ftsZ gene Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. Indicus|evm.model.PRDE01216404.1.33 Q03EY2 MURG_PEDPA 76.744 0.325729 2.17956 murG - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - murG gene Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). Indicus|evm.model.PRDE01216404.1.34 Q03EY1 MURD_PEDPA 71.847 0.374788 2.5978 murD - UDP-N-acetylmuramoylalanine--D-glutamate ligase - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - murD gene Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Indicus|evm.model.PRDE01216404.1.35 Q03EX7 RSMH_PEDPA 82.484 0.984277 1.01274 rsmH - Ribosomal RNA small subunit methyltransferase H - Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) - rsmH gene Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. Indicus|evm.model.PRDE01216404.1.36 Q88V72 FTSK_LACPL 58.235 0.97093 0.865409 ftsK - DNA translocase FtsK - Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) - ftsK gene Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). Indicus|evm.model.PRDE01216404.1.37 Q042B4 TRML_LACGA 62.500 0.708955 0.724324 LGAS_1346 - Putative RNA (cytidine(34)-2'-O)-methyltransferase - Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / BCRC 14619 / CIP 102991 / JCM 1131 / KCTC 3163 / NCIMB 11718 / NCTC 13722 / AM63) - LGAS_1346 gene Could methylate the ribose at the nucleotide 34 wobble position in tRNA. Indicus|evm.model.PRDE01216404.1.38 O86281 Y2431_LACLM 46.503 0.979094 0.841642 llmg_2431 - Uncharacterized protein llmg_2431 - Lactococcus lactis subsp. cremoris (strain MG1363) - llmg_2431 gene Indicus|evm.model.PRDE01216405.1.22 Q0KBP1 BKTB_CUPNH 70.588 0.98481 1.00254 bktB - Beta-ketothiolase BktB - Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) - bktB gene Required for efficient production of poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl-CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA. Indicus|evm.model.PRDE01216405.1.32 P0AC22 FOLX_SHIFL 63.478 0.974359 0.975 folX - Dihydroneopterin triphosphate 2'-epimerase - Shigella flexneri - folX gene Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis. Indicus|evm.model.PRDE01216405.1.33 Q9I351 GCH12_PSEAE 86.592 0.917526 1.07182 folE2 - GTP cyclohydrolase 1 2 - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - folE2 gene cytoplasm, GTP binding, GTP cyclohydrolase I activity, zinc ion binding, tetrahydrobiopterin biosynthetic process Indicus|evm.model.PRDE01216405.1.34 P07857 SCP2_BOVIN 51.010 0.989899 0.729282 SCP2 - Sterol carrier protein 2 - Bos taurus (Bovine) - SCP2 gene Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (By similarity). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). Indicus|evm.model.PRDE01216405.1.35 P96825 Y0148_MYCTU 47.807 0.774306 1.00699 Rv0148 - Putative short-chain type dehydrogenase/reductase Rv0148 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv0148 gene cell wall, plasma membrane, protein pupylation Indicus|evm.model.PRDE01216405.1.38 P96825 Y0148_MYCTU 49.356 0.765101 1.04196 Rv0148 - Putative short-chain type dehydrogenase/reductase Rv0148 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) - Rv0148 gene cell wall, plasma membrane, protein pupylation Indicus|evm.model.PRDE01216405.1.43 Q9HZP6 ETFB_PSEAE 93.976 0.447653 2.2249 etfB - Electron transfer flavoprotein subunit beta - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - etfB gene The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Indicus|evm.model.PRDE01216405.1.44 Q9I2V5 ACNB_PSEAE 87.572 0.96648 1.02992 acnB - Aconitate hydratase B - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - acnB gene Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein. Indicus|evm.model.PRDE01216405.1.46 Q3K6Q5 PANC_PSEPF 60.490 0.989583 1.00699 panC - Pantothenate synthetase - Pseudomonas fluorescens (strain Pf0-1) - panC gene Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Indicus|evm.model.PRDE01216405.1.47 Q53201 Y4UI_SINFN 50.000 0.846154 0.404669 NGR_a01310 - Putative transposase y4uI - Sinorhizobium fredii (strain NBRC 101917 / NGR234) - NGR_a01310 gene Indicus|evm.model.PRDE01216405.1.52 P37626 YHII_ECOLI 55.484 0.990385 0.878873 yhiI - Uncharacterized protein YhiI precursor - Escherichia coli (strain K12) - yhiI gene plasma membrane Indicus|evm.model.PRDE01216406.1.1 Q9HI37 TPF20_PSEAE 49.664 0.865497 0.505917 PA0445 - Probable family 20 transposase - Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) - PA0445 gene Required for the transposition of an insertion element. Indicus|evm.model.PRDE01216407.1.6 Q07736 T1RA_ECOLX 60.563 0.935366 1.01235 hsdR - Type I restriction enzyme EcoAI R protein - Escherichia coli - hsdR gene The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. Subunit R is required for both nuclease and ATPase activities, but not for modification. Indicus|evm.model.PRDE01216407.1.7 Q47282 T1ME_ECOLX 58.159 0.991632 0.97551 hsdM - Type I restriction enzyme EcoEI M protein - Escherichia coli - hsdM gene The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. The EcoEI enzyme recognizes 5'-GAGN(7)ATGC-3'.